Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample
MYSM1	114803	broad.mit.edu	37	1	59126842	59126842	+	Splice_Site	SNP	T	T	G			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr1:59126842T>G	ENST00000472487.1	-	19	2367	c.2328A>C	c.(2326-2328)aaA>aaC	p.K776N	MYSM1_ENST00000493821.1_5'UTR	NM_001085487.2	NP_001078956.1	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	776					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(7;9.36e-06)					GACAGCTTACTTTCTGCAAAC	0.378													5	27	---	---	---	---
DISP1	84976	broad.mit.edu	37	1	223178296	223178296	+	Missense_Mutation	SNP	A	A	T			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr1:223178296A>T	ENST00000284476.6	+	8	3721	c.3557A>T	c.(3556-3558)gAa>gTa	p.E1186V		NM_032890.3	NP_116279.2	Q96F81	DISP1_HUMAN	dispatched homolog 1 (Drosophila)	1186					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(20)|lung(25)|prostate(4)|skin(1)|stomach(1)|urinary_tract(5)	69				GBM - Glioblastoma multiforme(131;0.102)		CCAAAATCTGAACTGGAGCAT	0.458													5	59	---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228486309	228486309	+	Silent	SNP	G	G	A			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr1:228486309G>A	ENST00000570156.2	+	49	13175	c.13101G>A	c.(13099-13101)caG>caA	p.Q4367Q	OBSCN_ENST00000366709.4_Intron|OBSCN_ENST00000366707.4_Silent_p.Q1057Q|RP5-1139B12.4_ENST00000602778.1_RNA|OBSCN_ENST00000359599.6_3'UTR|OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000284548.11_Intron	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3410	Ig-like 45.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GCCTGAAGCAGGATGGGACGA	0.582													5	58	---	---	---	---
ZNF512	84450	broad.mit.edu	37	2	27838080	27838080	+	Missense_Mutation	SNP	C	C	G			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr2:27838080C>G	ENST00000355467.4	+	11	1260	c.1177C>G	c.(1177-1179)Cta>Gta	p.L393V	ZNF512_ENST00000379717.1_Missense_Mutation_p.L392V|ZNF512_ENST00000416005.2_Missense_Mutation_p.L364V|ZNF512_ENST00000556601.1_Missense_Mutation_p.L262V|RP11-158I13.2_ENST00000505973.1_RNA|ZNF512_ENST00000413371.2_Missense_Mutation_p.L316V	NM_001271287.1|NM_001271288.1|NM_001271289.1|NM_001271318.1|NM_032434.3	NP_001258216.1|NP_001258217.1|NP_001258218.1|NP_001258247.1|NP_115810.2	Q96ME7	ZN512_HUMAN	zinc finger protein 512	393					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)					CCAGGAAGTACTACATAAATG	0.358													3	62	---	---	---	---
CDC42EP3	10602	broad.mit.edu	37	2	37873410	37873410	+	Missense_Mutation	SNP	G	G	C			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr2:37873410G>C	ENST00000295324.3	-	2	1321	c.321C>G	c.(319-321)atC>atG	p.I107M	AC006369.2_ENST00000419425.1_RNA	NM_001270436.1|NM_001270437.1|NM_001270438.1|NM_006449.4	NP_001257365.1|NP_001257366.1|NP_001257367.1|NP_006440.2	Q9UKI2	BORG2_HUMAN	CDC42 effector protein (Rho GTPase binding) 3	107					regulation of cell shape|signal transduction	actin cytoskeleton|cytoplasm|endomembrane system|membrane	cytoskeletal regulatory protein binding			endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	11		all_hematologic(82;0.172)				TCGGGAGGGAGATGGCATTTT	0.547													6	53	---	---	---	---
TSGA10	80705	broad.mit.edu	37	2	99681428	99681428	+	Missense_Mutation	SNP	C	C	A			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr2:99681428C>A	ENST00000393483.3	-	16	2222	c.1378G>T	c.(1378-1380)Gat>Tat	p.D460Y	TSGA10_ENST00000539964.1_Missense_Mutation_p.D460Y|TSGA10_ENST00000478090.1_5'UTR|TSGA10_ENST00000410001.1_Missense_Mutation_p.D460Y|TSGA10_ENST00000355053.4_Missense_Mutation_p.D460Y	NM_025244.2	NP_079520.1	Q9BZW7	TSG10_HUMAN	testis specific, 10	460					spermatogenesis	cytoplasm|nuclear membrane				NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	34						TTGAGGGAATCTACTTTTTCT	0.373													7	52	---	---	---	---
XRN1	54464	broad.mit.edu	37	3	142151666	142151666	+	Missense_Mutation	SNP	C	C	T			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr3:142151666C>T	ENST00000264951.4	-	2	262	c.145G>A	c.(145-147)Gat>Aat	p.D49N	XRN1_ENST00000544157.1_5'UTR|XRN1_ENST00000392981.2_Missense_Mutation_p.D49N|XRN1_ENST00000463916.1_Missense_Mutation_p.D49N	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	49					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						TGAACATCATCATCATTAGGA	0.333													5	58	---	---	---	---
CCDC110	256309	broad.mit.edu	37	4	186392098	186392098	+	Splice_Site	SNP	C	C	G			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr4:186392098C>G	ENST00000307588.3	-	2	191		c.e2+1		CCDC110_ENST00000393540.3_Splice_Site|CCDC110_ENST00000507501.1_Splice_Site|CCDC110_ENST00000510617.1_Splice_Site	NM_152775.3	NP_689988.1	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110							nucleus				NS(1)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(9)	30		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		GGCGATTTTACCTGTGTCACT	0.552													35	123	---	---	---	---
RREB1	6239	broad.mit.edu	37	6	7240690	7240690	+	Nonsense_Mutation	SNP	T	T	A			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr6:7240690T>A	ENST00000379938.2	+	11	4365	c.3828T>A	c.(3826-3828)tgT>tgA	p.C1276*	RREB1_ENST00000379933.3_Intron|RREB1_ENST00000334984.6_Nonsense_Mutation_p.C1276*|RREB1_ENST00000349384.6_Intron	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	1272					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CCTTCCCTTGTCAAAAATGCG	0.413													16	77	---	---	---	---
COL12A1	1303	broad.mit.edu	37	6	75884866	75884866	+	Silent	SNP	G	G	A			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr6:75884866G>A	ENST00000322507.8	-	13	2907	c.2598C>T	c.(2596-2598)acC>acT	p.T866T	COL12A1_ENST00000483888.2_Silent_p.T866T|COL12A1_ENST00000345356.6_Intron|COL12A1_ENST00000416123.2_Silent_p.T866T	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	866	Fibronectin type-III 5.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						GCACCGTATTGGTTGTATCTC	0.527													18	118	---	---	---	---
CHRM2	1129	broad.mit.edu	37	7	136700393	136700393	+	Missense_Mutation	SNP	C	C	G			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr7:136700393C>G	ENST00000445907.2	+	3	1309	c.781C>G	c.(781-783)Cag>Gag	p.Q261E	hsa-mir-490_ENST00000597642.1_RNA|CHRM2_ENST00000453373.1_Missense_Mutation_p.Q261E|CHRM2_ENST00000320658.5_Missense_Mutation_p.Q261E|hsa-mir-490_ENST00000592183.1_RNA|hsa-mir-490_ENST00000425981.2_RNA|hsa-mir-490_ENST00000439694.1_RNA|CHRM2_ENST00000401861.1_Missense_Mutation_p.Q261E|CHRM2_ENST00000397608.3_Missense_Mutation_p.Q261E|hsa-mir-490_ENST00000593789.1_RNA|CHRM2_ENST00000402486.3_Missense_Mutation_p.Q261E|hsa-mir-490_ENST00000598184.1_RNA|hsa-mir-490_ENST00000586239.1_RNA	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	261					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	CAACAAAATCCAGAATGGCAA	0.517													3	20	---	---	---	---
TNNI2	7136	broad.mit.edu	37	11	1860932	1860932	+	Silent	SNP	A	A	G			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr11:1860932A>G	ENST00000381906.1	+	2	75	c.6A>G	c.(4-6)ggA>ggG	p.G2G	TNNI2_ENST00000252898.7_Silent_p.G2G|TNNI2_ENST00000381911.1_Silent_p.G2G	NM_001145829.1	NP_001139301.1	P48788	TNNI2_HUMAN	troponin I type 2 (skeletal, fast)	2	Involved in binding TNC.				muscle filament sliding|positive regulation of transcription, DNA-dependent|skeletal muscle contraction	cytosol|nucleus|troponin complex	actin binding|troponin T binding			lung(8)|prostate(1)|urinary_tract(1)	10		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		TCAGGATGGGAGAGTAAGTGG	0.632													3	21	---	---	---	---
CD63	967	broad.mit.edu	37	12	56120995	56120995	+	Silent	SNP	G	G	A			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr12:56120995G>A	ENST00000549117.1	-	3	631	c.195C>T	c.(193-195)ttC>ttT	p.F65F	CD63_ENST00000552754.1_Silent_p.F42F|CD63_ENST00000420846.3_Silent_p.F65F|CD63_ENST00000550776.1_5'UTR|CD63_ENST00000552692.1_Silent_p.F65F|CD63_ENST00000546939.1_5'UTR|CD63_ENST00000257857.4_Silent_p.F65F	NM_001257389.1	NP_001244318.1	P08962	CD63_HUMAN	CD63 molecule	65					platelet activation|platelet degranulation	integral to plasma membrane|late endosome membrane|lysosomal membrane|platelet dense granule membrane				kidney(1)|large_intestine(3)|lung(2)|ovary(1)	7						AAGCCACCAGGAAGAGGAAGA	0.592													7	43	---	---	---	---
MYCBP2	23077	broad.mit.edu	37	13	77672530	77672530	+	Missense_Mutation	SNP	G	G	C			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr13:77672530G>C	ENST00000407578.2	-	56	9025	c.8759C>G	c.(8758-8760)tCt>tGt	p.S2920C	MYCBP2_ENST00000360084.5_Missense_Mutation_p.S405C|MYCBP2_ENST00000544440.2_Missense_Mutation_p.S2882C|MYCBP2_ENST00000357337.6_Missense_Mutation_p.S2882C|MYCBP2_ENST00000482517.1_5'UTR|MYCBP2-AS1_ENST00000593933.1_RNA	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	2882					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CACATGGGGAGAGGGAGCTCT	0.473													9	74	---	---	---	---
CIRH1A	84916	broad.mit.edu	37	16	69194305	69194305	+	Silent	SNP	T	T	C			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr16:69194305T>C	ENST00000563094.1	+	13	1525	c.1491T>C	c.(1489-1491)aaT>aaC	p.N497N	CIRH1A_ENST00000314423.7_Silent_p.N497N|CIRH1A_ENST00000352319.4_Silent_p.N382N			Q969X6	CIR1A_HUMAN	cirrhosis, autosomal recessive 1A (cirhin)	497						nucleolus	protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	16				OV - Ovarian serous cystadenocarcinoma(108;0.125)		CAGATGGGAATTGGCTAGCTG	0.473													12	77	---	---	---	---
NME1	4830	broad.mit.edu	37	17	49239114	49239114	+	Missense_Mutation	SNP	G	G	A			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr17:49239114G>A	ENST00000336097.3	+	6	678	c.442G>A	c.(442-444)Gtg>Atg	p.V148M	NME1-NME2_ENST00000393198.3_Intron|NME2_ENST00000393193.2_Intron|NME1-NME2_ENST00000608447.1_Intron|NME1_ENST00000013034.3_Missense_Mutation_p.V148M|NME1_ENST00000393196.3_Missense_Mutation_p.V123M|NME1_ENST00000511355.1_3'UTR|NME2_ENST00000376392.6_Intron|NME2_ENST00000555572.1_Intron	NM_198175.1	NP_937818.1			NME/NM23 nucleoside diphosphate kinase 1											endometrium(1)|large_intestine(1)|lung(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)			CAGTGATTCTGTGGAGAGTGC	0.478													9	26	---	---	---	---
FBN3	84467	broad.mit.edu	37	19	8156424	8156424	+	Missense_Mutation	SNP	T	T	C			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr19:8156424T>C	ENST00000600128.1	-	48	6370	c.5956A>G	c.(5956-5958)Acc>Gcc	p.T1986A	FBN3_ENST00000270509.2_Missense_Mutation_p.T1986A|FBN3_ENST00000601739.1_Missense_Mutation_p.T1986A			Q75N90	FBN3_HUMAN	fibrillin 3	1986	EGF-like 32; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GGGCTGTTGGTACAGGTGCCA	0.587													3	39	---	---	---	---
GZF1	64412	broad.mit.edu	37	20	23347711	23347711	+	Missense_Mutation	SNP	T	T	A			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr20:23347711T>A	ENST00000338121.5	+	3	1513	c.1436T>A	c.(1435-1437)aTt>aAt	p.I479N	GZF1_ENST00000461789.1_Intron|GZF1_ENST00000377051.2_Missense_Mutation_p.I479N|GZF1_ENST00000544236.1_Missense_Mutation_p.I3N|GZF1_ENST00000542987.1_Intron			Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	479					transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|urinary_tract(2)	24	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					CACATGCTGATTTATCATAAA	0.353													4	33	---	---	---	---
RBM12	10137	broad.mit.edu	37	20	34242229	34242229	+	Missense_Mutation	SNP	A	A	G			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr20:34242229A>G	ENST00000374114.3	-	3	1279	c.1016T>C	c.(1015-1017)gTa>gCa	p.V339A	RBM12_ENST00000359646.1_Missense_Mutation_p.V339A|RP1-309K20.6_ENST00000541176.2_Intron|CPNE1_ENST00000397446.1_Intron|CPNE1_ENST00000397445.1_Intron|RBM12_ENST00000374104.3_Missense_Mutation_p.V339A|CPNE1_ENST00000397442.1_Intron|CPNE1_ENST00000317619.3_Intron|CPNE1_ENST00000397443.1_Intron|CPNE1_ENST00000352393.4_Intron	NM_001198838.1|NM_001198840.1|NM_006047.5	NP_001185767.1|NP_001185769.1|NP_006038.2	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	339	RRM 1.					nucleus	nucleotide binding|protein binding|RNA binding			breast(3)|endometrium(7)|kidney(1)|large_intestine(3)|lung(14)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			ATTTCGACCTACATGATCTTT	0.403													4	83	---	---	---	---
TTI1	9675	broad.mit.edu	37	20	36640365	36640365	+	Silent	SNP	G	G	A			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr20:36640365G>A	ENST00000373448.2	-	3	2092	c.1854C>T	c.(1852-1854)tgC>tgT	p.C618C	TTI1_ENST00000373447.3_Silent_p.C618C|TTI1_ENST00000449821.1_Silent_p.C618C|TTI1_ENST00000487362.1_5'UTR	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	618							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						TGTTCATGGAGCAAATAGTGG	0.458													4	96	---	---	---	---
SPANXD	64648	broad.mit.edu	37	X	140785702	140785702	+	Missense_Mutation	SNP	C	C	T			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chrX:140785702C>T	ENST00000370515.3	-	2	547	c.214G>A	c.(214-216)Gcc>Acc	p.A72T		NM_032417.2|NM_145665.1	NP_115793.1|NP_663698.1			SPANX family, member D											breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	9	Acute lymphoblastic leukemia(192;7.65e-05)					TTCTTTCGGGCGTGGTCATTC	0.433													5	160	---	---	---	---
LYST	1130	broad.mit.edu	37	1	235933474	235933482	+	In_Frame_Del	DEL	AAGTCAGTA	AAGTCAGTA	-			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chr1:235933474_235933482delAAGTCAGTA	ENST00000389794.3	-	20	6074_6082	c.5900_5908delTACTGACTT	c.(5899-5910)ctactgacttgt>cgt	p.1967_1970LLTC>R	LYST_ENST00000389793.2_In_Frame_Del_p.1967_1970LLTC>R|LYST_ENST00000536965.1_3'UTR			Q99698	LYST_HUMAN	lysosomal trafficking regulator	1967					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding	p.L1968L(1)		NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			AAAACCTGACAAGTCAGTAGAAAGTGATG	0.354													7	108	---	---	---	---
KDM6A	7403	broad.mit.edu	37	X	44918544	44918545	+	Frame_Shift_Ins	INS	-	-	G			TCGA-XA-A8JR-01A-11D-A364-08	TCGA-XA-A8JR-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6df7e9e-c584-4526-afb2-fa4b5199b174	814a1d39-a0af-491b-bb21-8afa1dd84729	g.chrX:44918544_44918545insG	ENST00000377967.4	+	12	1068_1069	c.1027_1028insG	c.(1027-1029)tgtfs	p.C343fs	KDM6A_ENST00000536777.1_Frame_Shift_Ins_p.C343fs|KDM6A_ENST00000543216.1_Frame_Shift_Ins_p.C343fs|KDM6A_ENST00000382899.4_Frame_Shift_Ins_p.C343fs	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	343					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)|p.0(2)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						GGCCTATATTTGTGCTGTACAA	0.436			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								8	16	---	---	---	---
