Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample
RPRD2	23248	broad.mit.edu	37	1	150429782	150429782	+	Missense_Mutation	SNP	A	A	T			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr1:150429782A>T	ENST00000401000.4	+	7	876	c.811A>T	c.(811-813)Aac>Tac	p.N271Y	RPRD2_ENST00000492220.1_3'UTR|RPRD2_ENST00000369068.4_Missense_Mutation_p.N297Y|RPRD2_ENST00000539519.1_Missense_Mutation_p.N271Y			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	297							protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						AACCTTTGCTAACCGAGTAAA	0.388													10	49	---	---	---	---
ASH1L	55870	broad.mit.edu	37	1	155348170	155348170	+	Silent	SNP	A	A	T			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr1:155348170A>T	ENST00000368346.3	-	10	6888	c.6249T>A	c.(6247-6249)gtT>gtA	p.V2083V	ASH1L_ENST00000392403.3_Silent_p.V2078V			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	2083					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GTTTGACATCAACGTAGACAT	0.413													23	110	---	---	---	---
MIA3	375056	broad.mit.edu	37	1	222838751	222838751	+	Silent	SNP	A	A	T			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr1:222838751A>T	ENST00000344922.5	+	28	5539	c.5514A>T	c.(5512-5514)ggA>ggT	p.G1838G	MIA3_ENST00000340535.7_Silent_p.G716G|MIA3_ENST00000344441.6_Silent_p.G1838G|MIA3_ENST00000344507.1_Intron	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1838	Pro-rich.				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		TTTTACCTGGACACGCACCAT	0.547													17	301	---	---	---	---
NDUFB5	4711	broad.mit.edu	37	3	179341804	179341804	+	Silent	SNP	T	T	A			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr3:179341804T>A	ENST00000493866.1	+	4	415	c.390T>A	c.(388-390)tcT>tcA	p.S130S	NDUFB5_ENST00000473500.1_3'UTR|NDUFB5_ENST00000472629.1_Silent_p.S170S|NDUFB5_ENST00000259037.3_Silent_p.S182S	NM_001199957.1	NP_001186886.1	O43674	NDUB5_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa	182					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			endometrium(1)|lung(6)|skin(1)	8	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)		NADH(DB00157)	TTGATCATTCTCCGAAAGCAA	0.333													7	129	---	---	---	---
TNFRSF10B	8795	broad.mit.edu	37	8	22886093	22886093	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr8:22886093C>T	ENST00000276431.4	-	5	783	c.499G>A	c.(499-501)Gtc>Atc	p.V167I	TNFRSF10B_ENST00000542226.1_Missense_Mutation_p.V16I|TNFRSF10B_ENST00000347739.3_Missense_Mutation_p.V167I|TNFRSF10B_ENST00000519910.1_5'UTR	NM_003842.4|NM_147187.2	NP_003833.4|NP_671716.2	O14763	TR10B_HUMAN	tumor necrosis factor receptor superfamily, member 10b	167					activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cell surface receptor linked signaling pathway|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|positive regulation of I-kappaB kinase/NF-kappaB cascade	plasma membrane	caspase activator activity|receptor activity|TRAIL binding			NS(1)|endometrium(2)|large_intestine(7)|liver(1)|lung(3)|skin(1)	15		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0179)|COAD - Colon adenocarcinoma(73;0.0703)		CAATCACCGACCTTGACCATC	0.567													5	88	---	---	---	---
ZFAT	57623	broad.mit.edu	37	8	135524840	135524840	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr8:135524840G>A	ENST00000520727.1	-	15	3502	c.3203C>T	c.(3202-3204)gCa>gTa	p.A1068V	ZFAT_ENST00000429442.2_Missense_Mutation_p.A1068V|ZFAT_ENST00000520214.1_Missense_Mutation_p.A1068V|ZFAT_ENST00000523399.1_Missense_Mutation_p.A1018V|ZFAT_ENST00000377838.3_Missense_Mutation_p.A1080V|ZFAT_ENST00000520356.1_Intron|ZFAT_ENST00000517307.1_5'UTR	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	1080					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			AGCTTCTGTTGCTGTCTAAAT	0.473													6	99	---	---	---	---
PAX5	5079	broad.mit.edu	37	9	37015117	37015117	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr9:37015117A>G	ENST00000358127.4	-	3	361	c.287T>C	c.(286-288)gTg>gCg	p.V96A	PAX5_ENST00000414447.1_Missense_Mutation_p.V96A|PAX5_ENST00000377853.2_Missense_Mutation_p.V96A|PAX5_ENST00000377847.2_Missense_Mutation_p.V96A|PAX5_ENST00000520281.1_Missense_Mutation_p.V96A|PAX5_ENST00000522003.1_5'UTR|PAX5_ENST00000520154.1_Missense_Mutation_p.V96A|PAX5_ENST00000523145.1_5'UTR|PAX5_ENST00000377852.2_Missense_Mutation_p.V96A|PAX5_ENST00000446742.1_Intron|PAX5_ENST00000523241.1_Missense_Mutation_p.V96A	NM_001280554.1|NM_001280556.1|NM_016734.1	NP_001267483.1|NP_001267485.1|NP_057953.1	Q02548	PAX5_HUMAN	paired box 5	96	Paired.				cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(42)	PAX5/JAK2(18)	NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(151)|kidney(1)|lung(10)|prostate(1)|skin(1)	171		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		GATTTTTTCCACCACTTTGGG	0.502			"""T, Mis, D, F, S"""	"""IGH@, ETV6, PML, FOXP1, ZNF521, ELN"""	"""NHL, ALL, B-ALL"""								30	202	---	---	---	---
HSPA14	51182	broad.mit.edu	37	10	14909224	14909224	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr10:14909224T>C	ENST00000378372.3	+	11	1375	c.1136T>C	c.(1135-1137)aTt>aCt	p.I379T		NM_016299.2	NP_057383.2	Q0VDF9	HSP7E_HUMAN	heat shock 70kDa protein 14	379					'de novo' cotranslational protein folding	cytosol	ATP binding|protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(3)|lung(4)|ovary(2)	17						GGAATTCTTATTGGGAAAGAA	0.383													10	106	---	---	---	---
NDST2	8509	broad.mit.edu	37	10	75567743	75567743	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr10:75567743T>C	ENST00000603027.1	-	3	1027	c.404A>G	c.(403-405)tAt>tGt	p.Y135C	NDST2_ENST00000309979.6_Missense_Mutation_p.Y135C|NDST2_ENST00000299641.4_Missense_Mutation_p.Y12C						135																	GACCAAGACATAGCGGCCATG	0.522													11	62	---	---	---	---
PRMT3	10196	broad.mit.edu	37	11	20515515	20515515	+	Splice_Site	SNP	G	G	T			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr11:20515515G>T	ENST00000331079.6	+	14	1615	c.1398G>T	c.(1396-1398)agG>agT	p.R466S	PRMT3_ENST00000437750.2_Splice_Site_p.R404S	NM_001145167.1|NM_005788.3	NP_001138639.1|NP_005779	O60678	ANM3_HUMAN	protein arginine methyltransferase 3	466							zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|prostate(1)	17						GCCACAACAGGGTAAGTATCA	0.279													16	111	---	---	---	---
GRIA4	2893	broad.mit.edu	37	11	105797470	105797470	+	Silent	SNP	C	C	T			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr11:105797470C>T	ENST00000393127.2	+	13	2297	c.1851C>T	c.(1849-1851)tcC>tcT	p.S617S	GRIA4_ENST00000282499.5_Silent_p.S617S|GRIA4_ENST00000530497.1_Silent_p.S617S|GRIA4_ENST00000525187.1_Silent_p.S617S	NM_001077243.2	NP_001070711	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	617					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	tgtttagaTCCCTCTCAGGTC	0.363													8	109	---	---	---	---
SLC6A15	55117	broad.mit.edu	37	12	85270287	85270287	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr12:85270287A>G	ENST00000266682.5	-	6	1397	c.856T>C	c.(856-858)Ttt>Ctt	p.F286L	SLC6A15_ENST00000552192.1_Missense_Mutation_p.F179L|SLC6A15_ENST00000551388.1_5'UTR	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	286					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						TTAGGGGTAAACATGTGGCGA	0.299													5	66	---	---	---	---
HSPH1	10808	broad.mit.edu	37	13	31727071	31727071	+	Silent	SNP	T	T	G			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr13:31727071T>G	ENST00000320027.5	-	5	791	c.447A>C	c.(445-447)acA>acC	p.T149T	HSPH1_ENST00000445273.2_Silent_p.T151T|HSPH1_ENST00000429785.2_Intron|HSPH1_ENST00000380406.5_Silent_p.T108T|HSPH1_ENST00000380405.4_Silent_p.T149T	NM_006644.2	NP_006635.2	Q92598	HS105_HUMAN	heat shock 105kDa/110kDa protein 1	149					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		TCTCAGCATCTGTAAAGAAGG	0.358													53	182	---	---	---	---
RFXAP	5994	broad.mit.edu	37	13	37399674	37399674	+	Splice_Site	SNP	T	T	C			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr13:37399674T>C	ENST00000255476.2	+	2	842		c.e2+2		RFXAP_ENST00000472888.1_Splice_Site	NM_000538.3	NP_000529.1	O00287	RFXAP_HUMAN	regulatory factor X-associated protein							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|ovary(1)	4		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;3.5e-07)|Epithelial(112;1.27e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.0069)|BRCA - Breast invasive adenocarcinoma(63;0.0116)|GBM - Glioblastoma multiforme(144;0.0405)		AAAAGACTGGTAAATATCTGT	0.313													11	47	---	---	---	---
KDELC1	79070	broad.mit.edu	37	13	103445972	103445972	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr13:103445972G>C	ENST00000376004.4	-	3	909	c.573C>G	c.(571-573)caC>caG	p.H191Q	KDELC1_ENST00000460338.1_5'UTR	NM_024089.2	NP_076994.2	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1	191						endoplasmic reticulum lumen				central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TTAAGGTGTAGTGACATAGGC	0.368													24	105	---	---	---	---
CUL4A	8451	broad.mit.edu	37	13	113899533	113899533	+	Silent	SNP	C	C	T	rs141571594		TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr13:113899533C>T	ENST00000451881.1	+	14	1461	c.1212C>T	c.(1210-1212)atC>atT	p.I404I	CUL4A_ENST00000375440.4_Silent_p.I504I|CUL4A_ENST00000326335.4_Silent_p.I404I|CUL4A_ENST00000375441.3_Silent_p.I404I	NM_001278513.1|NM_003589.2	NP_001265442.1|NP_003580.1	Q13619	CUL4A_HUMAN	cullin 4A	504					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|skin(1)	17	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			CGAAGGACATCATGGTTCATT	0.488													3	54	---	---	---	---
UNC79	57578	broad.mit.edu	37	14	94053216	94053216	+	Missense_Mutation	SNP	A	A	T			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr14:94053216A>T	ENST00000553484.1	+	22	3148	c.2994A>T	c.(2992-2994)caA>caT	p.Q998H	UNC79_ENST00000256339.4_Missense_Mutation_p.Q821H|UNC79_ENST00000393151.2_Missense_Mutation_p.Q998H|UNC79_ENST00000555664.1_Missense_Mutation_p.Q998H			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	998						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						ATCACCCTCAATTTTTAGCCT	0.353													33	141	---	---	---	---
ZNF839	55778	broad.mit.edu	37	14	102793195	102793195	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr14:102793195G>A	ENST00000262236.5	+	2	1169	c.814G>A	c.(814-816)Gtg>Atg	p.V272M	ZNF839_ENST00000559185.1_Missense_Mutation_p.V272M|ZNF839_ENST00000558850.1_Missense_Mutation_p.V272M|ZNF839_ENST00000442396.2_Missense_Mutation_p.V388M	NM_018335.4	NP_060805.3	A8K0R7	ZN839_HUMAN	zinc finger protein 839	272						intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						CTCCTGCTTGGTGACAGAGTC	0.577													4	14	---	---	---	---
NPAP1	23742	broad.mit.edu	37	15	24923886	24923886	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr15:24923886C>A	ENST00000329468.2	+	1	3346	c.2872C>A	c.(2872-2874)Cct>Act	p.P958T		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		ATTGGGCACACCTGTTAATGC	0.483													15	92	---	---	---	---
WDR72	256764	broad.mit.edu	37	15	53907788	53907788	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr15:53907788T>C	ENST00000396328.1	-	15	2854	c.2615A>G	c.(2614-2616)gAt>gGt	p.D872G	WDR72_ENST00000360509.5_Missense_Mutation_p.D872G|WDR72_ENST00000557913.1_Missense_Mutation_p.D869G|WDR72_ENST00000559418.1_Missense_Mutation_p.D882G	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	872										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TGTGTATTTATCTGACAAGTC	0.353													4	90	---	---	---	---
RASL12	51285	broad.mit.edu	37	15	65347485	65347485	+	Missense_Mutation	SNP	G	G	A	rs148588039	byFrequency	TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr15:65347485G>A	ENST00000220062.4	-	5	829	c.553C>T	c.(553-555)Cgg>Tgg	p.R185W	RASL12_ENST00000434605.2_Missense_Mutation_p.R174W|RASL12_ENST00000421977.3_Missense_Mutation_p.R166W	NM_016563.2	NP_057647.1	Q9NYN1	RASLC_HUMAN	RAS-like, family 12	185					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			lung(1)|ovary(1)|skin(1)|urinary_tract(1)	4						TCCAGCTCCCGCCGTGCCTCT	0.662													3	16	---	---	---	---
TPSAB1	7177	broad.mit.edu	37	16	1291297	1291297	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr16:1291297G>T	ENST00000461509.2	+	2	420	c.226G>T	c.(226-228)Gtg>Ttg	p.V76L	TPSAB1_ENST00000338844.3_Missense_Mutation_p.V69L			P20231	TRYB2_HUMAN	tryptase alpha/beta 1	69	Peptidase S1.				proteolysis	extracellular region	protein binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|skin(1)	10		Hepatocellular(780;0.00369)				CCCCCAGTGGGTGCTGACCGC	0.706													8	65	---	---	---	---
GLYR1	84656	broad.mit.edu	37	16	4873833	4873833	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr16:4873833T>C	ENST00000321919.9	-	6	689	c.613A>G	c.(613-615)Acc>Gcc	p.T205A	GLYR1_ENST00000586901.1_5'UTR|GLYR1_ENST00000436648.5_Missense_Mutation_p.T124A|GLYR1_ENST00000591451.1_Missense_Mutation_p.T205A|GLYR1_ENST00000381983.3_Missense_Mutation_p.T205A	NM_032569.3	NP_115958	Q49A26	GLYR1_HUMAN	glyoxylate reductase 1 homolog (Arabidopsis)	205					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	19						TCGCTTGCGGTTGGCTGCCAT	0.532													32	125	---	---	---	---
AFG3L2	10939	broad.mit.edu	37	18	12370900	12370900	+	Silent	SNP	T	T	C			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr18:12370900T>C	ENST00000269143.3	-	3	471	c.240A>G	c.(238-240)ggA>ggG	p.G80G		NM_006796.2	NP_006787.2	Q9Y4W6	AFG32_HUMAN	AFG3-like AAA ATPase 2	80					cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(12)|prostate(3)|skin(1)|stomach(3)|urinary_tract(1)	27					Adenosine triphosphate(DB00171)	TTCCATTTTTTCCATTAGGAA	0.279													4	24	---	---	---	---
ZNF521	25925	broad.mit.edu	37	18	22807246	22807246	+	Silent	SNP	C	C	T			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr18:22807246C>T	ENST00000361524.3	-	4	784	c.636G>A	c.(634-636)ctG>ctA	p.L212L	ZNF521_ENST00000538137.2_Silent_p.L212L|ZNF521_ENST00000584787.1_5'UTR	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	212					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					AACTAGAGGACAGAAACCCAC	0.493			T	PAX5	ALL								13	60	---	---	---	---
FCGBP	8857	broad.mit.edu	37	19	40362965	40362965	+	Silent	SNP	C	C	A			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr19:40362965C>A	ENST00000221347.6	-	32	15112	c.15105G>T	c.(15103-15105)gtG>gtT	p.V5035V		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	5035	VWFD 12.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CTGCCAAGCACACTGGGCAGC	0.706													5	40	---	---	---	---
PRKD2	25865	broad.mit.edu	37	19	47219514	47219514	+	Silent	SNP	G	G	A			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr19:47219514G>A	ENST00000433867.1	-	2	591	c.114C>T	c.(112-114)atC>atT	p.I38I	PRKD2_ENST00000601806.1_5'UTR|PRKD2_ENST00000291281.4_Silent_p.I38I|PRKD2_ENST00000595515.1_Silent_p.I38I	NM_001079880.1|NM_001079881.1|NM_016457.4	NP_001073349|NP_001073350|NP_057541	Q9BZL6	KPCD2_HUMAN	protein kinase D2	38					cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	41		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		CCGGGGCCGGGATCTGGGGCA	0.716													7	61	---	---	---	---
ZNF83	55769	broad.mit.edu	37	19	53117664	53117664	+	Silent	SNP	A	A	G			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr19:53117664A>G	ENST00000597597.1	-	2	2407	c.154T>C	c.(154-156)Tta>Cta	p.L52L	ZNF83_ENST00000301096.3_Silent_p.L52L|ZNF83_ENST00000594682.2_3'UTR|ZNF83_ENST00000600714.1_Intron|ZNF83_ENST00000391789.4_Silent_p.L52L|ZNF83_ENST00000544146.1_Silent_p.L52L|ZNF83_ENST00000536937.1_Silent_p.L52L|ZNF83_ENST00000545872.1_Silent_p.L52L|ZNF83_ENST00000601257.1_Intron|ZNF83_ENST00000541777.2_Silent_p.L52L			P51522	ZNF83_HUMAN	zinc finger protein 83	52						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		GGGGAAACTAAGGAACTACTG	0.353													13	87	---	---	---	---
EXOC4	60412	broad.mit.edu	37	7	132937913	132937914	+	Frame_Shift_Ins	INS	-	-	C			TCGA-ZG-A8QW-01A-11D-A377-08	TCGA-ZG-A8QW-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad06d026-2957-43c1-9350-74ddc23917e4	166a3681-aabe-4ffd-ae66-5ceee10893bf	g.chr7:132937913_132937914insC	ENST00000253861.4	+	1	85_86	c.56_57insC	c.(55-60)gaccccfs	p.DP19fs	EXOC4_ENST00000393161.2_Frame_Shift_Ins_p.DP19fs	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	19					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				AAAAGCAAAGACCCCTCGGGGC	0.624													15	64	---	---	---	---
