Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
CELA2A	63036	broad.mit.edu	37	1	15789290	15789290	+	Missense_Mutation	SNP	C	C	T	rs146502483		TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr1:15789290C>T	uc001awk.2	+	4	316	c.290C>T	c.(289-291)TCG>TTG	p.S97L		NM_033440	NP_254275	P08217	CEL2A_HUMAN	elastase 2A preproprotein	97	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						GAGTCCGGCTCGCTGGCAGTC	0.612000												
C1orf123	54987	broad.mit.edu	37	1	53684566	53684566	+	Silent	SNP	C	C	T	rs148279601		TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr1:53684566C>T	uc001cvd.2	-	3	162	c.120G>A	c.(118-120)TCG>TCA	p.S40S	C1orf123_uc001cvc.2_5'Flank|C1orf123_uc001cve.2_Intron	NM_017887	NP_060357	Q9NWV4	CA123_HUMAN	hypothetical protein LOC54987	40										pancreas(2)	2						GCCACTTGTCCGAAATCTCAC	0.493000												
C8B	732	broad.mit.edu	37	1	57399077	57399077	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr1:57399077C>A	uc001cyp.2	-	10	1550	c.1483G>T	c.(1483-1485)GAG>TAG	p.E495*	C8B_uc010oon.1_Nonsense_Mutation_p.E433*|C8B_uc010ooo.1_Nonsense_Mutation_p.E443*	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	495	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						TTCTGGAACTCCTCCAGTGCC	0.527000												
DENND2D	79961	broad.mit.edu	37	1	111737247	111737247	+	Silent	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr1:111737247G>A	uc001eak.1	-	7	947	c.747C>T	c.(745-747)GCC>GCT	p.A249A	DENND2D_uc001eal.1_Silent_p.A246A	NM_024901	NP_079177	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	249	DENN.									ovary(1)	1		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		GCACGGCAGAGGCAAAGATCT	0.527000												
TFB2M	64216	broad.mit.edu	37	1	246729331	246729331	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr1:246729331G>A	uc001ibn.2	-	1	235	c.110C>T	c.(109-111)CCG>CTG	p.P37L	CNST_uc001ibo.3_5'Flank|CNST_uc001ibp.2_5'Flank|TFB2M_uc010pys.1_RNA	NM_022366	NP_071761	Q9H5Q4	TFB2M_HUMAN	transcription factor B2, mitochondrial	37					positive regulation of transcription, DNA-dependent|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity|transcription cofactor activity			ovary(1)	1	all_cancers(71;4.25e-05)|all_epithelial(71;4.92e-06)|Ovarian(71;0.0254)|all_lung(81;0.0272)|Breast(184;0.0318)|Lung NSC(105;0.0376)		OV - Ovarian serous cystadenocarcinoma(106;0.00358)			GTTCCTCGCCGGCAAATGCTT	0.627000												
OR2T4	127074	broad.mit.edu	37	1	248524923	248524923	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr1:248524923C>T	uc001ieh.1	+	1	41	c.41C>T	c.(40-42)TCG>TTG	p.S14L		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACTGGATGGTCGGATTTCATC	0.488000												
ITIH5	80760	broad.mit.edu	37	10	7684001	7684001	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr10:7684001C>T	uc001ijq.2	-	3	267	c.188G>A	c.(187-189)CGT>CAT	p.R63H	ITIH5_uc001ijr.1_Missense_Mutation_p.R63H	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	63	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						GAAGGCATAACGGGAAATGAT	0.438000												
NEBL	10529	broad.mit.edu	37	10	21097582	21097582	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr10:21097582G>A	uc001iqi.2	-	26	3015	c.2618C>T	c.(2617-2619)GCG>GTG	p.A873V	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	873	Linker.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						ATAGTGACTCGCCTTTTCTAT	0.403000												
C10orf71	118461	broad.mit.edu	37	10	50530877	50530877	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr10:50530877C>T	uc010qgp.1	+	3	626	c.287C>T	c.(286-288)GCG>GTG	p.A96V		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	96											0						TCGGGCTGGGCGGCCACCTTC	0.577000												
C10orf71	118461	broad.mit.edu	37	10	50531976	50531976	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr10:50531976C>A	uc010qgp.1	+	3	1725	c.1386C>A	c.(1384-1386)AGC>AGA	p.S462R		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	462											0						CAGCAGACAGCCAGCCAGCAG	0.537000												
RGR	5995	broad.mit.edu	37	10	86008690	86008690	+	Silent	SNP	C	C	T	rs149839596	byFrequency	TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr10:86008690C>T	uc001kdc.1	+	3	287	c.249C>T	c.(247-249)TAC>TAT	p.Y83Y	RGR_uc001kdb.1_Missense_Mutation_p.R71W|RGR_uc001kdd.1_Silent_p.Y87Y|RGR_uc001kde.1_Silent_p.Y83Y	NM_001012720	NP_001012738	P47804	RGR_HUMAN	retinal G-protein coupled receptor isoform 2	83	Extracellular (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding			ovary(1)	1						GCTGGCCCTACGGCTCGGACG	0.622000												
TCTN3	26123	broad.mit.edu	37	10	97444352	97444352	+	Silent	SNP	A	A	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr10:97444352A>T	uc001klb.3	-	9	1243	c.999T>A	c.(997-999)ACT>ACA	p.T333T	TCTN3_uc001kla.3_Silent_p.T182T|TCTN3_uc010qoi.1_Intron|TCTN3_uc001kld.2_Silent_p.T351T|TCTN3_uc009xux.1_Silent_p.T155T|TCTN3_uc009xuy.1_RNA	NM_015631	NP_056446	Q6NUS6	TECT3_HUMAN	tectonic 3 isoform a precursor	333	Extracellular (Potential).				apoptosis	integral to membrane					0		Colorectal(252;0.0815)		Epithelial(162;1.69e-07)|all cancers(201;5.63e-06)		GGATTCCAAAAGTCCCATTGG	0.408000												
FAM175B	23172	broad.mit.edu	37	10	126517346	126517346	+	Silent	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr10:126517346C>T	uc001lib.3	+	6	525	c.480C>T	c.(478-480)CTC>CTT	p.L160L		NM_032182	NP_115558	Q15018	F175B_HUMAN	hypothetical protein LOC23172	160						BRISC complex	polyubiquitin binding				0						GGATATCACTCGCTATTCCCA	0.358000												
ANO2	57101	broad.mit.edu	37	12	5672628	5672628	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr12:5672628A>C	uc001qnm.2	-	26	2906	c.2834T>G	c.(2833-2835)TTC>TGC	p.F945C		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	950	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						CTCTTTCAGGAAGAAATCCAC	0.552000												
CPNE8	144402	broad.mit.edu	37	12	39154659	39154659	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr12:39154659G>A	uc001rls.1	-	10	796	c.712C>T	c.(712-714)CGA>TGA	p.R238*		NM_153634	NP_705898	Q86YQ8	CPNE8_HUMAN	copine VIII	238	C2 2.									pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				CTTCCATCTCGGTCCCAGTCA	0.323000												
C12orf51	283450	broad.mit.edu	37	12	112711519	112711519	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr12:112711519G>C	uc009zwc.2	-	4	604	c.586C>G	c.(586-588)CAA>GAA	p.Q196E	C12orf51_uc010syk.1_Missense_Mutation_p.Q19E|C12orf51_uc001tts.2_Missense_Mutation_p.Q19E|C12orf51_uc001ttt.3_Missense_Mutation_p.Q19E	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						TGGAAGGCTTGATTCCCAGGG	0.458000												
WASF3	10810	broad.mit.edu	37	13	27256755	27256755	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr13:27256755C>T	uc001uqv.2	+	9	1220	c.995C>T	c.(994-996)GCG>GTG	p.A332V	WASF3_uc001uqw.2_Missense_Mutation_p.A329V	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	332					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		ATGCTCCCAGCGCAGATAATT	0.552000												
DCLK1	9201	broad.mit.edu	37	13	36410272	36410272	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr13:36410272G>A	uc001uvf.2	-	8	1360	c.1127C>T	c.(1126-1128)TCG>TTG	p.S376L	DCLK1_uc001uve.3_Missense_Mutation_p.S69L|DCLK1_uc010teh.1_Missense_Mutation_p.S69L|DCLK1_uc010abk.2_Intron	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	376					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		GCCTTCCTCCGACACTTCTGA	0.353000												
DZIP1	22873	broad.mit.edu	37	13	96237021	96237021	+	Silent	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr13:96237021G>A	uc001vmk.2	-	22	3345	c.2493C>T	c.(2491-2493)GGC>GGT	p.G831G	DZIP1_uc001vmi.2_Silent_p.G79G|DZIP1_uc001vmj.2_Silent_p.G307G|DZIP1_uc001vml.2_Silent_p.G812G|DZIP1_uc001vmm.2_5'Flank	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	831					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			GATTAAATGCGCCCCAGGCAT	0.408000												
SIX4	51804	broad.mit.edu	37	14	61186876	61186876	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr14:61186876C>T	uc001xfc.2	-	2	1151	c.1151G>A	c.(1150-1152)GGA>GAA	p.G384E	SIX4_uc010app.1_Missense_Mutation_p.G376E	NM_017420	NP_059116	Q9UIU6	SIX4_HUMAN	sine oculis homeobox homolog 4	384						nucleus				breast(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		CTGTGTATTTCCCACATTTAA	0.423000												
PRKCH	5583	broad.mit.edu	37	14	61997205	61997205	+	Silent	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr14:61997205C>T	uc001xfn.2	+	12	1958	c.1653C>T	c.(1651-1653)CAC>CAT	p.H551H	PRKCH_uc010tsa.1_Silent_p.H390H|PRKCH_uc010tsb.1_Silent_p.H119H	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	551	Protein kinase.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		TCTGTGGTCACGCGCCTTTTG	0.552000												
C15orf26	161502	broad.mit.edu	37	15	81428869	81428869	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr15:81428869G>A	uc002bgb.2	+	3	199	c.172G>A	c.(172-174)GTA>ATA	p.V58I	C15orf26_uc010blp.1_Missense_Mutation_p.V33I	NM_173528	NP_775799	Q6P656	CO026_HUMAN	hypothetical protein LOC161502	58											0						GCAACTTTCCGTAACTGAAGA	0.408000												
LUC7L	55692	broad.mit.edu	37	16	240114	240114	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr16:240114C>T	uc002cgc.1	-	9	938	c.827G>A	c.(826-828)CGT>CAT	p.R276H	LUC7L_uc002cga.1_Missense_Mutation_p.R276H|LUC7L_uc002cgd.1_RNA|LUC7L_uc002cge.1_Missense_Mutation_p.R276H|LUC7L_uc002cgb.1_Missense_Mutation_p.R190H	NM_201412	NP_958815	Q9NQ29	LUC7L_HUMAN	LUC7-like isoform b	276	Arg/Ser-rich.						metal ion binding			central_nervous_system(1)	1		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)				CCGCCTCCGACGCCGATCCCG	0.622000												
AXIN1	8312	broad.mit.edu	37	16	347940	347940	+	Silent	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr16:347940C>T	uc002cgp.1	-	6	1743	c.1566G>A	c.(1564-1566)GCG>GCA	p.A522A	AXIN1_uc002cgq.1_Silent_p.A522A	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	522	Interaction with RNF111.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				CGTCCAGCTTCGCCCCTGACT	0.716000												
PRR25	388199	broad.mit.edu	37	16	855739	855739	+	Silent	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr16:855739G>A	uc010uut.1	+	1	297	c.297G>A	c.(295-297)CCG>CCA	p.P99P		NM_001013638	NP_001013660	Q96S07	PRR25_HUMAN	proline rich 25	99										large_intestine(1)	1						CAGCGCAGCCGCTCGCAAATG	0.647000												
SNX29	92017	broad.mit.edu	37	16	12293530	12293530	+	Silent	SNP	A	A	G	rs142571390	by1000genomes	TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr16:12293530A>G	uc002dby.3	+	7	569	c.513A>G	c.(511-513)CAA>CAG	p.Q171Q	SNX29_uc010uyx.1_Silent_p.Q198Q	NM_001080530	NP_001073999	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	171					cell communication		phosphatidylinositol binding			ovary(1)	1						GAGAAGGTCAAACAGCTGAAG	0.493000												
SALL1	6299	broad.mit.edu	37	16	51174418	51174418	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr16:51174418G>A	uc010vgs.1	-	2	1746	c.1715C>T	c.(1714-1716)ACG>ATG	p.T572M	SALL1_uc010vgr.1_Missense_Mutation_p.T475M|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	572					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGGCTCTTCCGTCTTGATGAA	0.602000												
TRADD	8717	broad.mit.edu	37	16	67189149	67189149	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr16:67189149G>A	uc002eri.1	-	4	558	c.478C>T	c.(478-480)CGA>TGA	p.R160*	TRADD_uc002erh.1_Nonsense_Mutation_p.R100*	NM_003789	NP_003780	Q15628	TRADD_HUMAN	TNFRSF1A-associated via death domain	160					activation of caspase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|tumor necrosis factor-mediated signaling pathway	cytoskeleton|cytosol|receptor complex	binding, bridging|death domain binding|identical protein binding|kinase binding|signal transducer activity			lung(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		TTCAGATTTCGCAGCGCATCC	0.701000												
TP53	7157	broad.mit.edu	37	17	7577022	7577022	+	Nonsense_Mutation	SNP	G	G	A	rs121913344		TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr17:7577022G>A	uc002gim.2	-	8	1110	c.916C>T	c.(916-918)CGA>TGA	p.R306*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.R306*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R174*|TP53_uc010cng.1_Nonsense_Mutation_p.R174*|TP53_uc002gii.1_Nonsense_Mutation_p.R174*|TP53_uc010cnh.1_Nonsense_Mutation_p.R306*|TP53_uc010cni.1_Nonsense_Mutation_p.R306*|TP53_uc002gij.2_Nonsense_Mutation_p.R306*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	306	Bipartite nuclear localization signal.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.		R -> Q (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R306*(99)|p.0?(7)|p.?(3)|p.R306R(2)|p.R306fs*39(2)|p.K305fs*1(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGCTTACCTCGCTTAGTGCTC	0.562000	R306*(MFE296_ENDOMETRIUM)|R306*(HCC1937_BREAST)|R306*(MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R306*(RCM1_LARGE_INTESTINE)|R306*(JURLMK1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
MYST2	11143	broad.mit.edu	37	17	47903390	47903390	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr17:47903390A>C	uc002ipm.2	+	13	1635	c.1509A>C	c.(1507-1509)AAA>AAC	p.K503N	MYST2_uc010wma.1_Missense_Mutation_p.K364N|MYST2_uc010wmb.1_Missense_Mutation_p.K393N|MYST2_uc010wmc.1_Missense_Mutation_p.K334N|MYST2_uc010wmd.1_Missense_Mutation_p.K347N|MYST2_uc010wme.1_Missense_Mutation_p.K317N|MYST2_uc010wmf.1_Missense_Mutation_p.K168N|MYST2_uc010wmg.1_Missense_Mutation_p.K58N	NM_007067	NP_008998	O95251	MYST2_HUMAN	MYST histone acetyltransferase 2	503					DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						TCGAAGAAAAAGTTGGCTCCC	0.428000												
INSR	3643	broad.mit.edu	37	19	7132311	7132311	+	Silent	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr19:7132311G>A	uc002mgd.1	-	14	2809	c.2700C>T	c.(2698-2700)GTC>GTT	p.V900V	INSR_uc002mge.1_Silent_p.V888V	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	900	Fibronectin type-III 3.|Extracellular (Potential).				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCTTGCGGGAGACGCAGAGAT	0.652000												
OR1M1	125963	broad.mit.edu	37	19	9204290	9204290	+	Missense_Mutation	SNP	G	G	A	rs148262558	by1000genomes	TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr19:9204290G>A	uc010xkj.1	+	1	370	c.370G>A	c.(370-372)GTG>ATG	p.V124M		NM_001004456	NP_001004456	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M,	124	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3						TGACCGGTTCGTGGCCATCTG	0.552000												
SLC5A5	6528	broad.mit.edu	37	19	17994560	17994560	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr19:17994560C>T	uc002nhr.3	+	11	1660	c.1313C>T	c.(1312-1314)CCG>CTG	p.P438L		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	438	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4						ATGTTCCTGCCGGCCTGCAAC	0.562000												
KIAA1683	80726	broad.mit.edu	37	19	18378091	18378091	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr19:18378091C>T	uc002nin.2	-	3	475	c.259G>A	c.(259-261)GAG>AAG	p.E87K	KIAA1683_uc010ebn.2_Missense_Mutation_p.E87K|KIAA1683_uc010xqe.1_Missense_Mutation_p.E41K	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	87						mitochondrion				ovary(2)	2						GCCTGGCTCTCGACCACAGCC	0.647000												
ZNF536	9745	broad.mit.edu	37	19	31040026	31040026	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr19:31040026C>T	uc002nsu.1	+	4	3638	c.3500C>T	c.(3499-3501)TCA>TTA	p.S1167L	ZNF536_uc010edd.1_Missense_Mutation_p.S1167L	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1167					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					ATTGCCTCCTCAGAGGACATG	0.527000												
GGN	199720	broad.mit.edu	37	19	38876902	38876902	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr19:38876902G>A	uc002oij.1	-	3	1135	c.1000C>T	c.(1000-1002)CGG>TGG	p.R334W	GGN_uc002oik.1_Intron|GGN_uc010efy.1_Missense_Mutation_p.R251W	NM_152657	NP_689870	Q86UU5	GGN_HUMAN	gametogenetin	334	Interaction with GGNBP1 (By similarity).|Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis						0	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GGTAGGGCCCGGGCTTGGGAC	0.667000												
NLRC4	58484	broad.mit.edu	37	2	32475567	32475567	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr2:32475567T>C	uc002roi.2	-	4	1612	c.1366A>G	c.(1366-1368)AGC>GGC	p.S456G	NLRC4_uc002roj.1_Missense_Mutation_p.S456G|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	456	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					AATAAACTGCTGAGTCTTCGT	0.438000												
NRXN1	9378	broad.mit.edu	37	2	50733718	50733718	+	Silent	SNP	G	G	C			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr2:50733718G>C	uc010fbq.2	-	13	4009	c.2532C>G	c.(2530-2532)CTC>CTG	p.L844L	NRXN1_uc002rxb.3_Silent_p.L476L|NRXN1_uc002rxe.3_Silent_p.L804L|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CGTTATCATTGAGGTTATAGC	0.448000												
BMP10	27302	broad.mit.edu	37	2	69093087	69093087	+	Silent	SNP	G	G	A	rs113361577		TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr2:69093087G>A	uc002sez.1	-	2	1110	c.951C>T	c.(949-951)AAC>AAT	p.N317N		NM_014482	NP_055297	O95393	BMP10_HUMAN	bone morphogenetic protein 10 preproprotein	317					activin receptor signaling pathway|adult heart development|atrial cardiac muscle tissue morphogenesis|BMP signaling pathway|cardiac muscle cell proliferation|heart trabecula formation|negative regulation of cardiac muscle hypertrophy|negative regulation of cell growth|negative regulation of endothelial cell migration|Notch signaling pathway|pathway-restricted SMAD protein phosphorylation|positive regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle hypertrophy|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent|sarcomere organization|ventricular cardiac muscle cell development|ventricular cardiac muscle tissue morphogenesis	cell surface|extracellular space|Z disc	cytokine activity|growth factor activity|receptor serine/threonine kinase binding			ovary(2)	2						TTCCTTTGGCGTTCCTTCTGA	0.517000												
SCTR	6344	broad.mit.edu	37	2	120236430	120236430	+	Silent	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr2:120236430C>T	uc002tma.2	-	3	484	c.258G>A	c.(256-258)GAG>GAA	p.E86E	SCTR_uc002tlz.2_5'UTR	NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	86	Extracellular (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)	GGCATTCCACCTCCACCATCC	0.612000												
CASP10	843	broad.mit.edu	37	2	202050848	202050848	+	Splice_Site	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr2:202050848G>A	uc002uxl.1	+	2	765	c.347_splice	c.e2+1	p.R116_splice	CASP10_uc002uxi.1_Splice_Site_p.R116_splice|CASP10_uc010zhn.1_Splice_Site|CASP10_uc002uxj.1_Splice_Site_p.R116_splice|CASP10_uc002uxk.1_Splice_Site_p.R116_splice|CASP10_uc010fta.1_Splice_Site_p.R116_splice|CASP10_uc002uxm.1_Splice_Site_p.R116_splice|CASP10_uc010ftb.1_Splice_Site	NM_032974	NP_116756	Q92851	CASPA_HUMAN	caspase 10 isoform b preproprotein						apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			skin(3)|ovary(1)|pancreas(1)|breast(1)	6						CTCTGTTTAGGTGAGGACGGG	0.498000												
PAK7	57144	broad.mit.edu	37	20	9561532	9561532	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr20:9561532C>T	uc002wnl.2	-	5	795	c.250G>A	c.(250-252)GGC>AGC	p.G84S	PAK7_uc002wnk.2_Missense_Mutation_p.G84S|PAK7_uc002wnj.2_Missense_Mutation_p.G84S|PAK7_uc010gby.1_Missense_Mutation_p.G84S	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	84	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			TCTAGCAGGCCGTTGATGGAG	0.463000												
XKR7	343702	broad.mit.edu	37	20	30584454	30584454	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr20:30584454G>A	uc002wxe.2	+	3	1108	c.934G>A	c.(934-936)GCC>ACC	p.A312T		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	312						integral to membrane				ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CAGCATTGCCGCCCGCGGCCT	0.632000												
MYL9	10398	broad.mit.edu	37	20	35176528	35176528	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr20:35176528A>C	uc002xfl.1	+	3	372	c.278A>C	c.(277-279)AAG>ACG	p.K93T	uc002xfk.3_Intron|MYL9_uc002xfm.1_Intron	NM_006097	NP_006088	P24844	MYL9_HUMAN	myosin regulatory light chain 9 isoform a	93					axon guidance|muscle contraction|regulation of muscle contraction	cytosol|muscle myosin complex	calcium ion binding|structural constituent of muscle				0	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				TTTGGGGAGAAGCTGAACGGC	0.612000												
ZHX3	23051	broad.mit.edu	37	20	39832810	39832810	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr20:39832810G>T	uc002xjs.1	-	3	1125	c.747C>A	c.(745-747)AAC>AAA	p.N249K	ZHX3_uc002xjq.1_Intron|ZHX3_uc002xjr.1_Missense_Mutation_p.N249K|ZHX3_uc002xjt.1_Missense_Mutation_p.N249K|ZHX3_uc002xju.1_Missense_Mutation_p.N249K|ZHX3_uc002xjv.1_Missense_Mutation_p.N249K|ZHX3_uc002xjw.1_Missense_Mutation_p.N249K|ZHX3_uc010ggg.1_Missense_Mutation_p.N249K	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	249	Required for homodimerization and interaction with NFYA.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				CGGCATGGGGGTTTTTTGCAG	0.587000												
NCOA3	8202	broad.mit.edu	37	20	46266482	46266482	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr20:46266482C>T	uc002xtk.2	+	13	2672	c.2467C>T	c.(2467-2469)CAT>TAT	p.H823Y	NCOA3_uc010ght.1_Missense_Mutation_p.H833Y|NCOA3_uc002xtl.2_Missense_Mutation_p.H823Y|NCOA3_uc002xtm.2_Missense_Mutation_p.H823Y|NCOA3_uc002xtn.2_Missense_Mutation_p.H823Y|NCOA3_uc010zyc.1_Missense_Mutation_p.H618Y	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	823					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						AAATGGTAGTCATCTGGGGAC	0.358000												
TMPRSS3	64699	broad.mit.edu	37	21	43805630	43805630	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr21:43805630C>A	uc002zbb.2	-	6	661	c.460G>T	c.(460-462)GAT>TAT	p.D154Y	TMPRSS3_uc002zay.2_5'Flank|TMPRSS3_uc002zaz.2_Missense_Mutation_p.D27Y|TMPRSS3_uc002zba.2_Missense_Mutation_p.D27Y|TMPRSS3_uc002zbc.2_Missense_Mutation_p.D154Y|TMPRSS3_uc002zbd.2_Missense_Mutation_p.D154Y	NM_024022	NP_076927	P57727	TMPS3_HUMAN	transmembrane protease, serine 3 isoform 1	154	SRCR.|Extracellular (Potential).				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			ovary(2)|breast(1)	3						CTGAGGTTATCTGAACTCACA	0.498000												
PRAME	23532	broad.mit.edu	37	22	22890846	22890846	+	Silent	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr22:22890846C>T	uc002zwf.2	-	5	1329	c.1173G>A	c.(1171-1173)ACG>ACA	p.T391T	LOC96610_uc011aim.1_Intron|PRAME_uc011air.1_Silent_p.T375T|PRAME_uc010gtr.2_Silent_p.T391T|PRAME_uc002zwg.2_Silent_p.T391T|PRAME_uc002zwh.2_Silent_p.T391T|PRAME_uc002zwi.2_Silent_p.T391T|PRAME_uc002zwj.2_Silent_p.T391T|PRAME_uc002zwk.2_Silent_p.T391T	NM_206956	NP_996839	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	391	LRR 3.				apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			central_nervous_system(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		GCTGATCATCCGTGATCCCAC	0.567000												
WNT7A	7476	broad.mit.edu	37	3	13916592	13916592	+	Silent	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr3:13916592C>T	uc003bye.1	-	2	455	c.150G>A	c.(148-150)GCG>GCA	p.A50A		NM_004625	NP_004616	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family,	50					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			ovary(2)|breast(1)	3						TCTGGCAGATCGCCCGCTGTC	0.592000												
CELSR3	1951	broad.mit.edu	37	3	48664446	48664446	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr3:48664446C>T	uc003cuf.1	-	53	12094	c.12094G>A	c.(12094-12096)GGT>AGT	p.G4032S	SLC26A6_uc003cug.2_Missense_Mutation_p.G625S|SLC26A6_uc003cuh.2_Missense_Mutation_p.G646S|SLC26A6_uc010hke.2_Missense_Mutation_p.G478S|SLC26A6_uc003cuk.2_Missense_Mutation_p.G538S|SLC26A6_uc003cui.2_Missense_Mutation_p.G645S|SLC26A6_uc003cuj.2_Missense_Mutation_p.G627S|SLC26A6_uc011bbp.1_Missense_Mutation_p.G610S	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	Error:Variant_position_missing_in_Q9NYQ7_after_alignment					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TCTTCTTGACCATTGGCTGTT	0.607000												
ROBO1	6091	broad.mit.edu	37	3	78763664	78763664	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr3:78763664G>A	uc003dqe.2	-	8	1136	c.928C>T	c.(928-930)CGA>TGA	p.R310*	ROBO1_uc003dqb.2_Nonsense_Mutation_p.R271*|ROBO1_uc003dqc.2_Nonsense_Mutation_p.R271*|ROBO1_uc003dqd.2_Nonsense_Mutation_p.R271*|ROBO1_uc003dqf.1_5'UTR	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	310	Extracellular (Potential).|Ig-like C2-type 3.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TGATCATCTCGGATTTCATAT	0.378000												
PLCXD2	257068	broad.mit.edu	37	3	111432963	111432963	+	Missense_Mutation	SNP	C	C	T	rs139070081	byFrequency	TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr3:111432963C>T	uc003dya.2	+	3	1440	c.854C>T	c.(853-855)ACG>ATG	p.T285M	PLCXD2_uc003dyb.2_Missense_Mutation_p.T285M|PLCXD2_uc003dxz.2_Missense_Mutation_p.T285M	NM_001134478	NP_001127950	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X	285					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(1)	1						CTCAAGAACACGCTGGTTCAT	0.493000												
PLCH1	23007	broad.mit.edu	37	3	155198891	155198891	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr3:155198891G>A	uc011bok.1	-	23	5225	c.4948C>T	c.(4948-4950)CGG>TGG	p.R1650W	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Missense_Mutation_p.R1612W	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1650					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GGGATGCCCCGGCCTTCAAGG	0.557000												
KLF3	51274	broad.mit.edu	37	4	38690545	38690545	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr4:38690545C>T	uc003gth.3	+	3	729	c.397C>T	c.(397-399)CGG>TGG	p.R133W	KLF3_uc003gtg.2_Missense_Mutation_p.R133W	NM_016531	NP_057615	P57682	KLF3_HUMAN	Kruppel-like factor 3 (basic)	133	Pro-rich.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						TGCCCTCTCGCGGCATGGAAT	0.617000												
TMEM150C	441027	broad.mit.edu	37	4	83406787	83406787	+	Silent	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr4:83406787G>A	uc003hmy.1	-	8	705	c.627C>T	c.(625-627)GGC>GGT	p.G209G	TMEM150C_uc011ccj.1_Silent_p.G239G	NM_001080506	NP_001073975	B9EJG8	T150C_HUMAN	transmembrane protein 150C	209	Helical; (Potential).					integral to membrane				ovary(1)	1						CGGCAAAGGTGCCAAAATAAG	0.512000												
IRF1	3659	broad.mit.edu	37	5	131822699	131822699	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr5:131822699G>T	uc003kxa.2	-	4	545	c.311C>A	c.(310-312)TCA>TAA	p.S104*	IRF1_uc003kxd.2_RNA|IRF1_uc003kxb.2_Nonsense_Mutation_p.S104*|IRF1_uc010jdt.1_Nonsense_Mutation_p.S104*	NM_002198	NP_002189	P10914	IRF1_HUMAN	interferon regulatory factor 1	104	IRF tryptophan pentad repeat.				blood coagulation|cellular response to mechanical stimulus|interferon-gamma-mediated signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleoplasm					0		all_cancers(142;0.026)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	LUAD - Lung adenocarcinoma(142;0.247)		TCGCACAGCTGAGCTGCCCTT	0.567000												
FSTL4	23105	broad.mit.edu	37	5	132545910	132545910	+	Silent	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr5:132545910G>A	uc003kyn.1	-	14	1907	c.1689C>T	c.(1687-1689)GAC>GAT	p.D563D	FSTL4_uc003kym.1_Silent_p.D212D	NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	563						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACTTGTGCACGTCCCCCCAGC	0.498000												
GRIA1	2890	broad.mit.edu	37	5	153085359	153085359	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr5:153085359A>T	uc003lva.3	+	11	1920	c.1555A>T	c.(1555-1557)AAA>TAA	p.K519*	GRIA1_uc003luy.3_Nonsense_Mutation_p.K519*|GRIA1_uc003luz.3_Nonsense_Mutation_p.K424*|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Nonsense_Mutation_p.K439*|GRIA1_uc011dcx.1_Nonsense_Mutation_p.K450*|GRIA1_uc011dcy.1_Nonsense_Mutation_p.K529*|GRIA1_uc011dcz.1_Nonsense_Mutation_p.K529*|GRIA1_uc010jia.1_Nonsense_Mutation_p.K499*	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	519	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CATCATGATTAAAAAACCACA	0.428000												
CFB	629	broad.mit.edu	37	6	31901495	31901495	+	Missense_Mutation	SNP	C	C	T	rs138034438	by1000genomes	TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr6:31901495C>T	uc011dor.1	+	3	629	c.365C>T	c.(364-366)ACG>ATG	p.T122M	C2_uc003nyc.2_Missense_Mutation_p.R16W|C2_uc011doo.1_Missense_Mutation_p.R16W|C2_uc011dop.1_Missense_Mutation_p.T61M|C2_uc003nye.3_Missense_Mutation_p.T184M|C2_uc003nyf.2_Missense_Mutation_p.T184M|C2_uc010jtk.2_Missense_Mutation_p.T52M|C2_uc011doq.1_Missense_Mutation_p.T155M|C2_uc003nyg.2_Missense_Mutation_p.T52M	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1						CTTGTGCTCACGGGGTCTTCG	0.642000												
TNXB	7148	broad.mit.edu	37	6	32017048	32017048	+	Silent	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr6:32017048C>T	uc003nzl.2	-	28	9952	c.9750G>A	c.(9748-9750)ACG>ACA	p.T3250T	TNXB_uc003nzh.1_5'Flank	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3297					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CCCACTCACCCGTGATGCCCA	0.637000												
NCR2	9436	broad.mit.edu	37	6	41309565	41309565	+	Missense_Mutation	SNP	G	G	A	rs142832518	byFrequency	TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr6:41309565G>A	uc003oqh.2	+	3	515	c.428G>A	c.(427-429)CGC>CAC	p.R143H	NCR2_uc003oqi.2_Missense_Mutation_p.R143H|NCR2_uc003oqj.2_Missense_Mutation_p.R143H	NM_004828	NP_004819	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	143	Extracellular (Potential).				cellular defense response	integral to plasma membrane	transmembrane receptor activity			ovary(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					TGGACTCCCCGCGACCTGGTC	0.617000												
RFPL4B	442247	broad.mit.edu	37	6	112671190	112671190	+	Missense_Mutation	SNP	C	C	T	rs142366862	byFrequency	TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr6:112671190C>T	uc003pvx.1	+	3	592	c.280C>T	c.(280-282)CGG>TGG	p.R94W		NM_001013734	NP_001013756	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	94	B30.2/SPRY.						zinc ion binding				0		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		CCGGCATTTTCGGGAGGATGT	0.522000												
HEY2	23493	broad.mit.edu	37	6	126080849	126080849	+	Silent	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr6:126080849G>A	uc003qad.2	+	5	1106	c.915G>A	c.(913-915)CCG>CCA	p.P305P	HEY2_uc011ebr.1_Silent_p.P259P	NM_012259	NP_036391	Q9UBP5	HEY2_HUMAN	hairy/enhancer-of-split related with YRPW motif	305					negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)		CCATCAGCCCGCCCTTGTCAG	0.597000												
MOXD1	26002	broad.mit.edu	37	6	132649655	132649655	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr6:132649655C>T	uc003qdf.2	-	5	841	c.742G>A	c.(742-744)GAC>AAC	p.D248N	MOXD1_uc003qde.2_Missense_Mutation_p.D180N	NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1 isoform 2	248	Lumenal (Potential).				catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			ovary(1)	1	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		AGAACGCTGTCGTTAAAGTTG	0.512000												
PHACTR2	9749	broad.mit.edu	37	6	144086652	144086652	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr6:144086652G>A	uc003qjq.3	+	6	1046	c.916G>A	c.(916-918)GAA>AAA	p.E306K	PHACTR2_uc010khh.2_Missense_Mutation_p.E226K|PHACTR2_uc010khi.2_Missense_Mutation_p.E317K|PHACTR2_uc003qjr.3_Missense_Mutation_p.E237K	NM_014721	NP_055536	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2 isoform 3	306							actin binding|protein phosphatase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		TTTCAAACTCGAACAGACTGT	0.562000												
ABCA13	154664	broad.mit.edu	37	7	48431656	48431656	+	Silent	SNP	C	C	T	rs147058958	by1000genomes	TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr7:48431656C>T	uc003toq.2	+	38	11818	c.11793C>T	c.(11791-11793)ACC>ACT	p.T3931T	ABCA13_uc010kys.1_Silent_p.T1005T|ABCA13_uc003tos.1_Silent_p.T757T|ABCA13_uc010kyt.1_RNA	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3931	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						ACAACCTCACCGTCCGGGAAC	0.507000												
FIGNL1	63979	broad.mit.edu	37	7	50514267	50514267	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr7:50514267A>T	uc003tpc.2	-	4	1096	c.719T>A	c.(718-720)GTG>GAG	p.V240E	FIGNL1_uc003tpb.2_Missense_Mutation_p.V129E|FIGNL1_uc003tpd.2_Missense_Mutation_p.V240E|FIGNL1_uc003tpe.2_Missense_Mutation_p.V240E|FIGNL1_uc010kyy.2_Missense_Mutation_p.V240E	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	240					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				AGATAAGAACACATTAAGTCC	0.393000												
LMTK2	22853	broad.mit.edu	37	7	97823365	97823365	+	Silent	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr7:97823365C>T	uc003upd.1	+	11	3881	c.3588C>T	c.(3586-3588)GAC>GAT	p.D1196D		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	1196					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					CCACGGAAGACGAGGCCAGCA	0.597000												
CAV1	857	broad.mit.edu	37	7	116199088	116199088	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr7:116199088C>T	uc003vif.1	+	3	562	c.284C>T	c.(283-285)ACG>ATG	p.T95M	CAV1_uc010lkd.1_Missense_Mutation_p.T64M|CAV1_uc010lke.1_Missense_Mutation_p.T64M|CAV1_uc003vig.1_RNA|CAV1_uc003vih.2_Missense_Mutation_p.T64M|CAV1_uc010lkf.1_Missense_Mutation_p.T64M	NM_001753	NP_001744	Q03135	CAV1_HUMAN	caveolin 1	95	Cytoplasmic (Potential).				blood coagulation|calcium ion transport|caveola assembly|cellular response to starvation|cholesterol homeostasis|cytosolic calcium ion homeostasis|inactivation of MAPK activity|interspecies interaction between organisms|leukocyte migration|lipid storage|maintenance of protein location in cell|mammary gland involution|membrane depolarization|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of endothelial cell proliferation|negative regulation of epithelial cell differentiation|negative regulation of nitric oxide biosynthetic process|negative regulation of peptidyl-serine phosphorylation|negative regulation of protein binding|negative regulation of transcription from RNA polymerase II promoter|nitric oxide homeostasis|nitric oxide metabolic process|positive regulation of calcium ion transport into cytosol|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of metalloenzyme activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of vasoconstriction|protein homooligomerization|receptor internalization|regulation of blood coagulation|regulation of fatty acid metabolic process|regulation of nitric-oxide synthase activity|regulation of smooth muscle contraction|response to calcium ion|response to estrogen stimulus|response to hypoxia|response to progesterone stimulus|skeletal muscle tissue development|T cell costimulation|triglyceride metabolic process|vasculogenesis|vesicle organization	apical plasma membrane|basolateral plasma membrane|caveola|caveola|cytosol|endoplasmic reticulum|endosome|Golgi membrane|lipid particle|perinuclear region of cytoplasm	cholesterol binding|nitric-oxide synthase binding|peptidase activator activity|protein binding|protein complex scaffold|receptor binding				0	all_epithelial(6;1.42e-06)|Lung NSC(10;0.0056)|all_lung(10;0.00609)		STAD - Stomach adenocarcinoma(10;0.00878)			TTCACTGTGACGAAATACTGG	0.483000												
TRPA1	8989	broad.mit.edu	37	8	72970030	72970030	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr8:72970030C>T	uc003xza.2	-	9	1190	c.1015G>A	c.(1015-1017)GAT>AAT	p.D339N		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	339	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	CCTTCAGAATCGATCTTATTA	0.338000												
RALYL	138046	broad.mit.edu	37	8	85774574	85774574	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr8:85774574G>A	uc003ycq.3	+	7	873	c.457G>A	c.(457-459)GTA>ATA	p.V153I	RALYL_uc003ycr.3_Missense_Mutation_p.V153I|RALYL_uc003ycs.3_Missense_Mutation_p.V153I|RALYL_uc010lzy.2_Missense_Mutation_p.V142I|RALYL_uc003yct.3_Missense_Mutation_p.V166I|RALYL_uc003ycu.3_Missense_Mutation_p.V80I|RALYL_uc003ycv.3_Missense_Mutation_p.V65I	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	153							identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						TCCCCGTGCAGTAATTCCGCT	0.512000												
FOXE1	2304	broad.mit.edu	37	9	100616580	100616580	+	Silent	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr9:100616580G>A	uc004axu.2	+	1	1044	c.384G>A	c.(382-384)GCG>GCA	p.A128A		NM_004473	NP_004464	O00358	FOXE1_HUMAN	forkhead box E1	128	Fork-head.				cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		Acute lymphoblastic leukemia(62;0.158)				ACTACTGGGCGCTTGACCCCA	0.637000												
OLFM1	10439	broad.mit.edu	37	9	138011806	138011806	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr9:138011806G>A	uc010nar.2	+	6	1556	c.1240G>A	c.(1240-1242)GTC>ATC	p.V414I	OLFM1_uc004cfl.3_Missense_Mutation_p.V396I|OLFM1_uc004cfn.3_Missense_Mutation_p.V165I	NM_014279	NP_055094	Q99784	NOE1_HUMAN	olfactomedin related ER localized protein	414	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		CACGCTGTACGTCACCAACGG	0.577000												
KIAA1210	57481	broad.mit.edu	37	X	118219449	118219449	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chrX:118219449G>T	uc004era.3	-	12	4745	c.4745C>A	c.(4744-4746)GCA>GAA	p.A1582E		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1582										ovary(4)|skin(1)	5						CTTCTGCTTTGCCATAGTTAT	0.448000												
MAP3K7	6885	broad.mit.edu	37	6	91271380	91271392	+	Splice_Site	DEL	GACACACCTAAAG	GACACACCTAAAG	-			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr6:91271379_91271391AGACACACCTAAAG>A	uc003pnz.1	-	4	603	c.298_splice	c.e4-1	p.V100_splice	MAP3K7_uc003pob.1_Splice_Site_p.V100_splice|MAP3K7_uc003poa.1_Splice_Site_p.V100_splice|MAP3K7_uc003poc.1_Splice_Site_p.V100_splice	NM_145331	NP_663304	O43318	M3K7_HUMAN	Homo sapiens mitogen-activated protein kinase kinase kinase 7 (MAP3K7), transcript variant B, mRNA.	100	Protein kinase.				I-kappaB phosphorylation|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|T cell receptor signaling pathway|Toll signaling pathway|activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|innate immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|positive regulation of interleukin-2 production|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|MAP kinase kinase kinase activity|magnesium ion binding|protein binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	28		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		TTCCATCACAAGACACACCTAAAGGAAACATAT	0.319												
SF1	7536	broad.mit.edu	37	11	64533312	64533312	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr11:64533312delG	uc001obb.1	-	13	2275	c.1898delC	c.(1897-1899)CCAfs	p.P633fs	SF1_uc010rnm.1_Intron|SF1_uc010rnn.1_Frame_Shift_Del_p.P607fs|SF1_uc001oaz.1_Intron|SF1_uc001oba.1_Intron|SF1_uc001obc.1_Intron|SF1_uc001obd.1_Intron|SF1_uc001obe.1_Intron|SF1_uc010rno.1_Intron	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1	633	Pro-rich.				nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3						TGGAGGCGGTGGGGGAGCTGG	0.517												
SEL1L3	23231	broad.mit.edu	37	4	25780725	25780725	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr4:25780724_25780724GA>G	uc003gru.4	-	15	2711	c.2559_2559TC>C	c.(2557-2559)ttcfs	p.F853fs	SEL1L3_uc003grv.3_Frame_Shift_Del_p.F260fs	NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	Homo sapiens sel-1 suppressor of lin-12-like 3 (C. elegans) (SEL1L3), mRNA.	853						integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						GATCTCTAGGGAATGTCTCCA	0.443												
MAP3K7	6885	broad.mit.edu	37	6	91271380	91271392	+	Splice_Site	DEL	GACACACCTAAAG	GACACACCTAAAG	-			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr6:91271379_91271391AGACACACCTAAAG>A	uc003pnz.1	-	4	603	c.298_splice	c.e4-1	p.V100_splice	MAP3K7_uc003pob.1_Splice_Site_p.V100_splice|MAP3K7_uc003poa.1_Splice_Site_p.V100_splice|MAP3K7_uc003poc.1_Splice_Site_p.V100_splice	NM_145331	NP_663304	O43318	M3K7_HUMAN	Homo sapiens mitogen-activated protein kinase kinase kinase 7 (MAP3K7), transcript variant B, mRNA.	100	Protein kinase.				I-kappaB phosphorylation|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|T cell receptor signaling pathway|Toll signaling pathway|activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|innate immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|positive regulation of interleukin-2 production|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|MAP kinase kinase kinase activity|magnesium ion binding|protein binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	28		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		TTCCATCACAAGACACACCTAAAGGAAACATAT	0.319												
PHKB	5257	broad.mit.edu	37	16	47694578	47694579	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr16:47694577_47694578A>AT	uc002eev.4	+	21	2095_2096	c.2043_2044A>AT	c.(2041-2046)gaatttfs	p.E681fs	PHKB_uc002eeu.4_Frame_Shift_Ins_p.E674fs	NM_000293	NP_000284	Q93100	KPBB_HUMAN	Homo sapiens phosphorylase kinase, beta (PHKB), transcript variant 1, mRNA.	681					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|liver(1)|lung(18)|ovary(1)|skin(1)	41		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				GGCTTCCAGAATTTAAGAGTTT	0.381												
KRTAP4-12	83755	broad.mit.edu	37	17	39280351	39280352	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr17:39280350_39280351CAG>C	uc002hwa.3	-	0	69_70	c.24_25CTG>G	c.(22-27)tctgtgfs	p.S8fs		NM_031854	NP_114060	Q9BQ66	KR412_HUMAN	Homo sapiens keratin associated protein 4-12 (KRTAP4-12), mRNA.	8	31 X 5 AA repeats of C-C-[GRQVIL]-[SPTR]- [VSTQPC].					keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TCAGAGCACACAGAGCCACAAC	0.599												
UNK	85451	broad.mit.edu	37	17	73819366	73819367	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr17:73819365_73819366AAG>A	uc002jpm.3	+	15	2267_2268	c.2267_2268AAG>A	c.(2266-2268)aaafs	p.K756fs	UNK_uc021udd.1_Frame_Shift_Del_p.K680fs	NM_001080419	NP_001073888	Q9C0B0	UNK_HUMAN	Homo sapiens unkempt homolog (Drosophila) (UNK), transcript variant 1, mRNA.	680							nucleic acid binding|zinc ion binding			cervix(3)|endometrium(8)|kidney(2)|large_intestine(5)|lung(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	25			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCCTGGAAGAAAGAGGCGGAGG	0.653												
ZNF569	148266	broad.mit.edu	37	19	37905171	37905172	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-8682-01A-11D-2394-08	TCGA-BR-8682-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea2055d1-7b8b-4aaf-9a70-8802f4deef9b	e959d24d-aab8-4a7e-a29c-5e2370ddcad8	g.chr19:37905170_37905171G>GA	uc002ogj.3	-	8	1393_1394	c.461_462C>TC	c.(460-462)ttcfs	p.F154fs	ZNF569_uc002ogh.3_5'UTR|ZNF569_uc002ogi.3_Frame_Shift_Ins_p.F130fs	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	Homo sapiens zinc finger protein 569 (ZNF569), mRNA.	130					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|endometrium(4)|large_intestine(16)|lung(11)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GTCTGGAAGGGAAAAAATCAGA	0.327												
