Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
ARID1A	8289	broad.mit.edu	37	1	27056214	27056214	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr1:27056214C>T	uc001bmv.1	+	2	1583	c.1210C>T	c.(1210-1212)CAA>TAA	p.Q404*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q404*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q404*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q21*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	404					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		ATACTCGCAGCAACAGGGACC	0.572000			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC							
PTCH2	8643	broad.mit.edu	37	1	45288225	45288225	+	Silent	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr1:45288225G>A	uc010olf.1	-	22	3486	c.3474C>T	c.(3472-3474)ACC>ACT	p.T1158T	PTCH2_uc010olg.1_Silent_p.T856T	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	1158	Cytoplasmic (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					CGGTCATGGAGGTAGTCACTC	0.647000									Basal_Cell_Nevus_syndrome			
LPHN2	23266	broad.mit.edu	37	1	82436147	82436147	+	Silent	SNP	T	T	C			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr1:82436147T>C	uc001dit.3	+	15	3013	c.2832T>C	c.(2830-2832)GGT>GGC	p.G944G	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Silent_p.G944G|LPHN2_uc001div.2_Silent_p.G944G|LPHN2_uc009wcd.2_Silent_p.G944G|LPHN2_uc001diw.2_Silent_p.G528G|LPHN2_uc009wce.1_Silent_p.G30G	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	957	Helical; Name=4; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		ATGTTGCTGGTTACTTGTTTC	0.388000												
KIF21B	23046	broad.mit.edu	37	1	200967659	200967659	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr1:200967659C>T	uc001gvs.1	-	14	2247	c.1930G>A	c.(1930-1932)GAA>AAA	p.E644K	KIF21B_uc001gvr.1_Missense_Mutation_p.E644K|KIF21B_uc009wzl.1_Missense_Mutation_p.E644K|KIF21B_uc010ppn.1_Missense_Mutation_p.E644K	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	644	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						TGCTTGATTTCGATCTCACAA	0.567000												
LYST	1130	broad.mit.edu	37	1	235973499	235973499	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr1:235973499G>A	uc001hxj.2	-	5	794	c.619C>T	c.(619-621)CGC>TGC	p.R207C	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.R207C	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	207					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GTTGCTAAGCGGTCAAGTTTA	0.413000									Chediak-Higashi_syndrome			
OR2T12	127064	broad.mit.edu	37	1	248458186	248458186	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr1:248458186C>T	uc010pzj.1	-	1	695	c.695G>A	c.(694-696)CGC>CAC	p.R232H		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			GGCCTTCTTGCGGGCTTCTGT	0.522000												
SIRT1	23411	broad.mit.edu	37	10	69676111	69676111	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr10:69676111A>G	uc001jnd.2	+	9	2058	c.2005A>G	c.(2005-2007)AGT>GGT	p.S669G	SIRT1_uc010qis.1_Missense_Mutation_p.S374G|SIRT1_uc009xpp.2_Missense_Mutation_p.S477G|SIRT1_uc001jne.2_Missense_Mutation_p.S366G	NM_012238	NP_036370	Q96EB6	SIRT1_HUMAN	sirtuin 1 isoform a	669					apoptosis|cell aging|cellular response to hydrogen peroxide|cellular response to starvation|chromatin silencing at rDNA|DNA repair|DNA replication|establishment of chromatin silencing|histone H3 deacetylation|interspecies interaction between organisms|maintenance of chromatin silencing|muscle organ development|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of fat cell differentiation|negative regulation of helicase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine acetylation|peptidyl-lysine deacetylation|positive regulation of anti-apoptosis|positive regulation of chromatin silencing|positive regulation of DNA repair|regulation of apoptosis|regulation of cell proliferation|regulation of endodeoxyribonuclease activity|regulation of protein import into nucleus, translocation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|rRNA processing|transcription, DNA-dependent|triglyceride mobilization|white fat cell differentiation	chromatin silencing complex|cytoplasm|nuclear euchromatin|nuclear heterochromatin|nuclear inner membrane|nucleolus|PML body|rDNA heterochromatin	bHLH transcription factor binding|histone binding|HLH domain binding|identical protein binding|mitogen-activated protein kinase binding|NAD+ binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|p53 binding|protein C-terminus binding|transcription corepressor activity|zinc ion binding				0						CTTATCCTCTAGTTCTTGTGG	0.408000												
MYPN	84665	broad.mit.edu	37	10	69934039	69934039	+	Silent	SNP	G	G	A	rs71584492		TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr10:69934039G>A	uc001jnm.3	+	12	2375	c.2190G>A	c.(2188-2190)ACG>ACA	p.T730T	MYPN_uc001jnn.3_Silent_p.T455T|MYPN_uc001jno.3_Silent_p.T730T|MYPN_uc009xpt.2_Silent_p.T730T|MYPN_uc010qit.1_Silent_p.T436T|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	730						nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						TCCCCTCCACGAACACCACCG	0.552000												
RBMXL2	27288	broad.mit.edu	37	11	7111052	7111052	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr11:7111052C>T	uc001mfc.2	+	1	888	c.701C>T	c.(700-702)TCG>TTG	p.S234L		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	234	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTTGCCCCCTCGCCCGGAGAG	0.687000												
PDE3B	5140	broad.mit.edu	37	11	14808127	14808127	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr11:14808127G>A	uc001mln.2	+	3	1527	c.1174G>A	c.(1174-1176)GGT>AGT	p.G392S	PDE3B_uc010rcr.1_Intron	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	392					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						TGCTTTCTCAGGTTCCTGTAG	0.448000												
PAMR1	25891	broad.mit.edu	37	11	35496285	35496285	+	Silent	SNP	G	G	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr11:35496285G>T	uc001mwg.2	-	4	430	c.387C>A	c.(385-387)GGC>GGA	p.G129G	PAMR1_uc001mwf.2_Silent_p.G129G|PAMR1_uc010rew.1_Intron|PAMR1_uc010rex.1_Silent_p.G89G	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	129	CUB.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						GCAGAACCTGGCCACATCCTA	0.448000												
SHANK2	22941	broad.mit.edu	37	11	70332291	70332291	+	Silent	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr11:70332291G>A	uc001oqc.2	-	21	4185	c.4107C>T	c.(4105-4107)ACC>ACT	p.T1369T	SHANK2_uc010rqn.1_Silent_p.T781T|SHANK2_uc001opz.2_Silent_p.T774T|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	990					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TGCCGGGCACGGTGGTGGGCT	0.622000												
FAT3	120114	broad.mit.edu	37	11	92430579	92430579	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr11:92430579G>C	uc001pdj.3	+	3	3654	c.3637G>C	c.(3637-3639)GAT>CAT	p.D1213H		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1213	Cadherin 11.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AAGGAAATTGGATCGAGAACA	0.378000										TCGA Ovarian(4;0.039)		
ARHGAP20	57569	broad.mit.edu	37	11	110453059	110453059	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr11:110453059C>T	uc001pkz.1	-	15	1991	c.1706G>A	c.(1705-1707)AGA>AAA	p.R569K	ARHGAP20_uc001pky.1_Missense_Mutation_p.R546K|ARHGAP20_uc009yyb.1_Missense_Mutation_p.R533K|ARHGAP20_uc001pla.1_Missense_Mutation_p.R533K|ARHGAP20_uc001plb.2_Missense_Mutation_p.R112K	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	569					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		GGCATTCTCTCTAGTGTCACA	0.413000												
DSCAML1	57453	broad.mit.edu	37	11	117389392	117389392	+	Silent	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr11:117389392G>A	uc001prh.1	-	7	1481	c.1479C>T	c.(1477-1479)GGC>GGT	p.G493G	DSCAML1_uc001pri.1_Silent_p.G297G	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	433	Extracellular (Potential).|Ig-like C2-type 5.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GGGGCGGGGCGCCCTTGGCCG	0.672000												
SNX19	399979	broad.mit.edu	37	11	130784835	130784835	+	Missense_Mutation	SNP	C	C	T	rs143532789		TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr11:130784835C>T	uc001qgk.3	-	1	1548	c.1000G>A	c.(1000-1002)GAA>AAA	p.E334K	SNX19_uc010sce.1_Intron|SNX19_uc010scf.1_Intron|SNX19_uc010scg.1_Intron|SNX19_uc001qgl.3_Missense_Mutation_p.E334K|SNX19_uc009zcx.1_Intron	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	334					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		TCTACAGCTTCGTGGCCTTCT	0.502000												
TROAP	10024	broad.mit.edu	37	12	49724178	49724178	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr12:49724178C>T	uc001rtx.3	+	13	1717	c.1550C>T	c.(1549-1551)CCG>CTG	p.P517L	TROAP_uc009zlh.2_Missense_Mutation_p.P517L|TROAP_uc001rty.2_Missense_Mutation_p.P225L	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	517	Cys-rich.|4 X 33 AA approximate tandem repeats.|1.				cell adhesion	cytoplasm				ovary(1)	1						CCCTGCCCTCCGGCAGAGCCT	0.602000												
NAP1L1	4673	broad.mit.edu	37	12	76449896	76449896	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr12:76449896C>A	uc001sxw.2	-	7	887	c.475G>T	c.(475-477)GAA>TAA	p.E159*	NAP1L1_uc001sxv.2_Nonsense_Mutation_p.E117*|NAP1L1_uc001sxz.2_Nonsense_Mutation_p.E90*|NAP1L1_uc001sxx.2_Nonsense_Mutation_p.E159*|NAP1L1_uc001sxy.2_Nonsense_Mutation_p.E96*|NAP1L1_uc010sty.1_Nonsense_Mutation_p.E116*|NAP1L1_uc010stz.1_5'UTR|NAP1L1_uc010sua.1_Nonsense_Mutation_p.E159*|NAP1L1_uc001syb.2_Nonsense_Mutation_p.E159*|NAP1L1_uc001sya.2_Nonsense_Mutation_p.E117*|NAP1L1_uc001syc.2_Nonsense_Mutation_p.E170*	NM_139207	NP_631946	P55209	NP1L1_HUMAN	nucleosome assembly protein 1-like 1	159					DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			ovary(1)|skin(1)	2		Colorectal(145;0.09)				TCTTTTTCTTCATCTTTTTTC	0.308000												
HAL	3034	broad.mit.edu	37	12	96377755	96377755	+	Silent	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr12:96377755C>T	uc001tem.1	-	15	1518	c.1221G>A	c.(1219-1221)GTG>GTA	p.V407V	HAL_uc009zti.1_RNA|HAL_uc010suw.1_Silent_p.V199V|HAL_uc010sux.1_Silent_p.V407V	NM_002108	NP_002099	P42357	HUTH_HUMAN	histidine ammonia-lyase	407					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			ovary(2)|skin(1)	3					L-Histidine(DB00117)	TTGTATCATTCACCACACCAT	0.323000												
WSCD2	9671	broad.mit.edu	37	12	108641966	108641966	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr12:108641966A>G	uc001tms.2	+	9	2288	c.1544A>G	c.(1543-1545)GAT>GGT	p.D515G	WSCD2_uc001tmt.2_Missense_Mutation_p.D515G|WSCD2_uc001tmu.2_Missense_Mutation_p.D283G	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	515						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						AGCCAGAAGGATGGCAACTTC	0.592000												
OAS3	4940	broad.mit.edu	37	12	113379558	113379558	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr12:113379558C>T	uc001tug.2	+	2	448	c.361C>T	c.(361-363)CCT>TCT	p.P121S	OAS3_uc001tue.2_Missense_Mutation_p.P121S|OAS3_uc001tuf.2_Missense_Mutation_p.P121S	NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	121	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						ACTCACGTTTCCTGAGCAGAG	0.607000												
FLT1	2321	broad.mit.edu	37	13	29001982	29001982	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr13:29001982C>T	uc001usb.3	-	9	1468	c.1183G>A	c.(1183-1185)GTA>ATA	p.V395I	FLT1_uc010aar.1_Missense_Mutation_p.V395I|FLT1_uc001usc.3_Missense_Mutation_p.V395I|FLT1_uc010tdp.1_Missense_Mutation_p.V395I	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	395	Ig-like C2-type 4.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TCTTCAGTTACGTCCTTGATA	0.388000												
TRPC4	7223	broad.mit.edu	37	13	38211356	38211356	+	Missense_Mutation	SNP	C	C	T	rs142683062	byFrequency	TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr13:38211356C>T	uc001uws.2	-	11	2853	c.2618G>A	c.(2617-2619)CGT>CAT	p.R873H	TRPC4_uc010abv.2_Missense_Mutation_p.R453H|TRPC4_uc001uwt.2_Missense_Mutation_p.R789H|TRPC4_uc010tey.1_Missense_Mutation_p.R732H|TRPC4_uc010abw.2_Missense_Mutation_p.R700H|TRPC4_uc010abx.2_Missense_Mutation_p.R878H|TRPC4_uc010aby.2_Missense_Mutation_p.R724H	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	873	Binds to ITPR1, ITPR2 and ITPR3.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		AGCCTGTTGACGAGCAACTTC	0.428000												
DAOA	267012	broad.mit.edu	37	13	106119489	106119489	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr13:106119489T>G	uc001vqb.2	+	2	406	c.132T>G	c.(130-132)ATT>ATG	p.I44M	DAOA_uc010tjf.1_Translation_Start_Site|DAOA_uc001vpz.2_RNA|DAOA_uc010agd.2_RNA|DAOA_uc010tjg.1_Translation_Start_Site|DAOA_uc001vqc.2_RNA|DAOA_uc001vqe.2_RNA	NM_172370	NP_758958	P59103	DAOA_HUMAN	D-amino acid oxidase activator isoform 1	44						Golgi apparatus					0	Lung NSC(43;0.01)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					TAAACTCTATTGGTATGTTAC	0.284000												
NPAS3	64067	broad.mit.edu	37	14	33684530	33684530	+	Silent	SNP	C	C	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr14:33684530C>A	uc001wru.2	+	3	347	c.283C>A	c.(283-285)CGA>AGA	p.R95R	NPAS3_uc001wrs.2_Silent_p.R65R|NPAS3_uc001wrt.2_Silent_p.R65R|NPAS3_uc001wrv.2_Silent_p.R65R|NPAS3_uc001wrw.2_5'UTR	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	95	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		ATCCATCATTCGACTTACAAT	0.493000												
DACT1	51339	broad.mit.edu	37	14	59113725	59113725	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr14:59113725C>T	uc001xdw.2	+	4	2548	c.2384C>T	c.(2383-2385)ACG>ATG	p.T795M	DACT1_uc010trv.1_Missense_Mutation_p.T514M|DACT1_uc001xdx.2_Missense_Mutation_p.T758M|DACT1_uc010trw.1_Missense_Mutation_p.T514M	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	795					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						CCCATTCAAACGGTAACGGCC	0.537000												
EVL	51466	broad.mit.edu	37	14	100595908	100595908	+	Silent	SNP	C	C	T	rs145112596	byFrequency	TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr14:100595908C>T	uc001ygt.2	+	7	959	c.720C>T	c.(718-720)GAC>GAT	p.D240D	EVL_uc001ygv.2_Silent_p.D246D|EVL_uc001ygu.2_Silent_p.D242D|EVL_uc010avu.2_Silent_p.D99D	NM_016337	NP_057421	Q9UI08	EVL_HUMAN	Enah/Vasp-like	240	EVH2.|EVH2 block A.				actin polymerization or depolymerization|axon guidance|cell surface receptor linked signaling pathway|organ morphogenesis	cytoskeleton|cytosol|focal adhesion|lamellipodium	actin binding|profilin binding|SH3 domain binding			large_intestine(2)|ovary(1)	3		Melanoma(154;0.152)				AGCCAGAAGACGCATCTGGAG	0.587000												
TGM7	116179	broad.mit.edu	37	15	43577123	43577123	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr15:43577123C>T	uc001zrf.1	-	7	898	c.893G>A	c.(892-894)CGT>CAT	p.R298H		NM_052955	NP_443187	Q96PF1	TGM7_HUMAN	transglutaminase 7	298					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)	2		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	GGAAACAACACGGGTTGGAAC	0.413000												
CLK3	1198	broad.mit.edu	37	15	74912538	74912538	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr15:74912538G>A	uc010uln.1	+	3	1246	c.785G>A	c.(784-786)CGC>CAC	p.R262H	CLK3_uc002ayg.3_Missense_Mutation_p.R114H|CLK3_uc002ayh.3_5'UTR|CLK3_uc010ulm.1_Missense_Mutation_p.R262H|CLK3_uc002ayj.3_Missense_Mutation_p.R114H|CLK3_uc002ayk.3_5'UTR	NM_001130028	NP_001123500	P49761	CLK3_HUMAN	CDC-like kinase 3 isoform a	262	Arg-rich.					acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)	2						CACAAACGCCGCACCAGGTCT	0.617000												
LYRM1	57149	broad.mit.edu	37	16	20926917	20926917	+	Missense_Mutation	SNP	C	C	T	rs149175521	byFrequency	TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr16:20926917C>T	uc010bwj.2	+	2	341	c.40C>T	c.(40-42)CGC>TGC	p.R14C	LYRM1_uc010bwi.1_RNA|LYRM1_uc010bwk.2_Intron|LYRM1_uc002dia.3_Missense_Mutation_p.R14C|LYRM1_uc010bwl.2_Missense_Mutation_p.R14C|LYRM1_uc010bwm.2_Intron|LYRM1_uc002dib.2_Missense_Mutation_p.R14C	NM_020424	NP_065157	O43325	LYRM1_HUMAN	LYR motif containing 1	14						nucleus					0						TGGCCTCTACCGCAGCATTTT	0.463000												
RANBP10	57610	broad.mit.edu	37	16	67762350	67762350	+	Missense_Mutation	SNP	G	G	A	rs146349352		TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr16:67762350G>A	uc002eud.2	-	11	1533	c.1417C>T	c.(1417-1419)CGC>TGC	p.R473C	RANBP10_uc010ceo.2_Missense_Mutation_p.R244C|RANBP10_uc010vju.1_Missense_Mutation_p.R447C|RANBP10_uc010vjv.1_Missense_Mutation_p.R386C|RANBP10_uc010vjw.1_Missense_Mutation_p.R164C	NM_020850	NP_065901	Q6VN20	RBP10_HUMAN	RAN binding protein 10	473										ovary(1)	1		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		TTAACAATGCGTGTGGACATG	0.587000												
DDX28	55794	broad.mit.edu	37	16	68056517	68056517	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr16:68056517C>G	uc002evh.1	-	1	1443	c.589G>C	c.(589-591)GAC>CAC	p.D197H	DUS2L_uc002evi.2_5'Flank|DUS2L_uc002evj.2_5'Flank|DUS2L_uc010vkk.1_5'Flank	NM_018380	NP_060850	Q9NUL7	DDX28_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28	197	Helicase ATP-binding.					mitochondrial nucleoid|nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0116)|Epithelial(162;0.0474)|all cancers(182;0.233)		GGAAGGGAGTCCAGGCTTGGC	0.657000												
ADAMTS18	170692	broad.mit.edu	37	16	77387771	77387771	+	Silent	SNP	C	C	A	rs148669189		TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr16:77387771C>A	uc002ffc.3	-	10	1892	c.1473G>T	c.(1471-1473)GCG>GCT	p.A491A	ADAMTS18_uc010chc.1_Silent_p.A79A|ADAMTS18_uc002ffe.1_Silent_p.A187A	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	491	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						CTAGACACCCCGCCTGAGGTG	0.418000												
TP53	7157	broad.mit.edu	37	17	7578526	7578526	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr17:7578526C>T	uc002gim.2	-	5	598	c.404G>A	c.(403-405)TGC>TAC	p.C135Y	TP53_uc002gig.1_Missense_Mutation_p.C135Y|TP53_uc002gih.2_Missense_Mutation_p.C135Y|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C3Y|TP53_uc010cng.1_Missense_Mutation_p.C3Y|TP53_uc002gii.1_Missense_Mutation_p.C3Y|TP53_uc010cnh.1_Missense_Mutation_p.C135Y|TP53_uc010cni.1_Missense_Mutation_p.C135Y|TP53_uc002gij.2_Missense_Mutation_p.C135Y|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C42Y|TP53_uc002gio.2_Missense_Mutation_p.C3Y|TP53_uc010vug.1_Missense_Mutation_p.C96Y	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	135	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> S (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation; decreased E6-mediated binding to E6-AP).|C -> T (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> R (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C135Y(51)|p.C135F(34)|p.C135W(19)|p.C135S(10)|p.C135fs*35(9)|p.0?(7)|p.C135*(7)|p.C135G(6)|p.C135R(6)|p.C135C(5)|p.C135fs*14(2)|p.N131fs*27(2)|p.F134_T140>S(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.C135T(1)|p.V73fs*9(1)|p.C135fs*36(1)|p.C135fs*15(1)|p.Y126fs*11(1)|p.C135_A138delCQLA(1)|p.C42Y(1)|p.C3Y(1)|p.M133fs*13(1)|p.C135_T140delCQLAKT(1)|p.Q136fs*13(1)|p.C135_Q136insXXXXXX(1)|p.C135_Q136insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCAGTTGGCAAAACATCTT	0.572000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
MYH1	4619	broad.mit.edu	37	17	10408543	10408543	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr17:10408543C>T	uc002gmo.2	-	21	2466	c.2372G>A	c.(2371-2373)CGA>CAA	p.R791Q	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	791	IQ.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GGCCTGGGTTCGGGTAATCAG	0.458000												
ZSWIM7	125150	broad.mit.edu	37	17	15890590	15890590	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr17:15890590C>T	uc002gpe.2	-	3	289	c.191G>A	c.(190-192)CGT>CAT	p.R64H	ZSWIM7_uc002gpf.2_Missense_Mutation_p.R64H|ZSWIM7_uc002gpg.2_RNA	NM_001042698	NP_001036163	Q19AV6	ZSWM7_HUMAN	zinc finger, SWIM-type containing 7	64					DNA recombination|DNA repair	nucleus	zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0827)		CTGGTAAACACGCCTTCCACT	0.468000												
FAM83G	644815	broad.mit.edu	37	17	18882956	18882956	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr17:18882956C>T	uc002guw.2	-	4	888	c.721G>A	c.(721-723)GAG>AAG	p.E241K	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	241										ovary(1)|central_nervous_system(1)	2						GTGAAGAACTCAGTTCCCCCG	0.582000												
GOSR2	9570	broad.mit.edu	37	17	45009523	45009523	+	Silent	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr17:45009523G>A	uc002ila.2	+	4	367	c.294G>A	c.(292-294)GAG>GAA	p.E98E	GOSR2_uc010wkh.1_Silent_p.E98E|GOSR2_uc002iky.2_Silent_p.E98E|GOSR2_uc002ikz.2_Silent_p.E98E	NM_004287	NP_004278	O14653	GOSR2_HUMAN	golgi SNAP receptor complex member 2 isoform A	98	Cytoplasmic (Potential).|Potential.				cellular membrane fusion|ER to Golgi vesicle-mediated transport|protein transport	Golgi membrane|integral to membrane	transporter activity			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(9;0.102)			AGCAGCAGGAGAGACAGCGAG	0.567000												
DLX3	1747	broad.mit.edu	37	17	48069062	48069062	+	Missense_Mutation	SNP	C	C	T	rs138972403		TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr17:48069062C>T	uc002ipy.2	-	3	909	c.683G>A	c.(682-684)CGC>CAC	p.R228H		NM_005220	NP_005211	O60479	DLX3_HUMAN	distal-less homeobox 3	228						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CAGCTGACTGCGGGCAGGGGC	0.637000												
COX11	1353	broad.mit.edu	37	17	53042077	53042077	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr17:53042077G>A	uc010wng.1	-	2	560	c.503C>T	c.(502-504)CCT>CTT	p.P168L	COX11_uc010wne.1_RNA|COX11_uc010wnf.1_RNA|COX11_uc002iue.2_RNA|COX11_uc010wnh.1_Missense_Mutation_p.P168L	NM_004375	NP_004366	Q9Y6N1	COX11_HUMAN	COX11 homolog, cytochrome c oxidase assembly	168	Mitochondrial intermembrane (Potential).|Mitochondrial matrix (Potential).				respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	copper ion binding|cytochrome-c oxidase activity|electron carrier activity			ovary(1)	1						TGTTTGCTGAGGTCTAAAGTT	0.343000												
PRKCA	5578	broad.mit.edu	37	17	64770166	64770166	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr17:64770166A>G	uc002jfp.1	+	14	1630	c.1586A>G	c.(1585-1587)TAT>TGT	p.Y529C	PRKCA_uc002jfo.1_Missense_Mutation_p.Y400C	NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha	529	Protein kinase.				activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	GTCCTGTTGTATGAAATGCTT	0.428000												
RECQL5	9400	broad.mit.edu	37	17	73627718	73627718	+	Silent	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr17:73627718G>A	uc010dgl.2	-	9	1416	c.1260C>T	c.(1258-1260)TTC>TTT	p.F420F	RECQL5_uc010dgk.2_Silent_p.F393F|RECQL5_uc002jot.3_5'Flank|LOC643008_uc002jow.2_5'Flank	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	420					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			GCGCATCCCCGAAGTACTTGG	0.697000								Other_identified_genes_with_known_or_suspected_DNA_repair_function				
CCDC40	55036	broad.mit.edu	37	17	78013951	78013951	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr17:78013951C>T	uc010dht.2	+	3	461	c.434C>T	c.(433-435)GCC>GTC	p.A145V	CCDC40_uc010wub.1_Missense_Mutation_p.A145V	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	145					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CAGCAAGAGGCCACCGGTCCA	0.597000												
SALL3	27164	broad.mit.edu	37	18	76752182	76752182	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr18:76752182C>A	uc002lmt.2	+	2	191	c.191C>A	c.(190-192)GCG>GAG	p.A64E	SALL3_uc010dra.2_5'Flank	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	64					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		TTCAAGTGGGCGGACTTCCTG	0.711000												
KCNN1	3780	broad.mit.edu	37	19	18092786	18092786	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr19:18092786C>T	uc002nht.2	+	5	1077	c.767C>T	c.(766-768)TCG>TTG	p.S256L	KCNN1_uc010xqa.1_Missense_Mutation_p.S256L	NM_002248	NP_002239	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance	256					synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity				0						ACGGACGCCTCGAGCCGCAGC	0.612000												
ZNF675	171392	broad.mit.edu	37	19	23844925	23844925	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr19:23844925C>T	uc002nri.2	-	3	399	c.217G>A	c.(217-219)GAA>AAA	p.E73K		NM_138330	NP_612203	Q8TD23	ZN675_HUMAN	zinc finger protein 675	73	KRAB.				bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				CCTGGGGGTTCATTCACCATC	0.418000												
APLP1	333	broad.mit.edu	37	19	36363501	36363501	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr19:36363501C>T	uc002oce.2	+	7	1105	c.967C>T	c.(967-969)CGC>TGC	p.R323C	APLP1_uc010xsz.1_Missense_Mutation_p.R284C|APLP1_uc002ocf.2_Missense_Mutation_p.R323C|APLP1_uc002ocg.2_Missense_Mutation_p.R226C|APLP1_uc010xta.1_Missense_Mutation_p.R317C	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	323	Heparin-binding (By similarity).|Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCGTAGGATGCGCCAGATTAA	0.537000												
C2orf43	60526	broad.mit.edu	37	2	20990056	20990056	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr2:20990056G>A	uc002rec.2	-	3	290	c.257C>T	c.(256-258)GCG>GTG	p.A86V	C2orf43_uc002rea.1_Missense_Mutation_p.A86V|C2orf43_uc002reb.1_RNA|C2orf43_uc010yka.1_Intron|C2orf43_uc010ykb.1_5'UTR|C2orf43_uc010ykc.1_Intron|C2orf43_uc010ykd.1_Missense_Mutation_p.A86V|C2orf43_uc010yke.1_Intron|C2orf43_uc010ykf.1_Intron	NM_021925	NP_068744	Q9H6V9	CB043_HUMAN	hypothetical protein LOC60526	86											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGAGCCAACGCATGCCCAGC	0.423000												
LTBP1	4052	broad.mit.edu	37	2	33572523	33572523	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr2:33572523G>A	uc002ros.2	+	26	3949	c.3949G>A	c.(3949-3951)GAA>AAA	p.E1317K	LTBP1_uc002rot.2_Missense_Mutation_p.E991K|LTBP1_uc002rou.2_Missense_Mutation_p.E990K|LTBP1_uc002rov.2_Missense_Mutation_p.E937K|LTBP1_uc010ymz.1_Missense_Mutation_p.E948K|LTBP1_uc010yna.1_Missense_Mutation_p.E895K|LTBP1_uc010ynb.1_Missense_Mutation_p.E214K	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1316	EGF-like 14; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GTGTGCTGATGAAAACCAAGA	0.542000												
GALNT5	11227	broad.mit.edu	37	2	158167802	158167802	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr2:158167802C>T	uc002tzg.2	+	10	3020	c.2765C>T	c.(2764-2766)GCC>GTC	p.A922V	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	922	Lumenal (Potential).|Ricin B-type lectin.				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						AAAGTAGCTGCCTGTGACCCA	0.338000												
ANKRD44	91526	broad.mit.edu	37	2	197987478	197987478	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr2:197987478C>T	uc002uuc.2	-	7	756	c.589G>A	c.(589-591)GCA>ACA	p.A197T	ANKRD44_uc002utz.3_5'UTR|ANKRD44_uc002uua.1_Missense_Mutation_p.A172T|ANKRD44_uc002uub.2_Missense_Mutation_p.A197T|ANKRD44_uc010zgw.1_Missense_Mutation_p.A125T	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	197	ANK 6.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			GTCACTTCTGCGCCATGGTTA	0.438000												
CASP8	841	broad.mit.edu	37	2	202137426	202137426	+	Silent	SNP	C	C	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr2:202137426C>A	uc002uxr.1	+	5	686	c.477C>A	c.(475-477)ATC>ATA	p.I159I	CASP8_uc010ftc.1_Silent_p.I159I|CASP8_uc002uxo.1_Silent_p.I159I|CASP8_uc002uxp.1_Silent_p.I191I|CASP8_uc002uxq.1_Silent_p.I159I|CASP8_uc002uxs.1_Silent_p.I159I|CASP8_uc002uxt.1_Silent_p.I218I|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Silent_p.I56I|CASP8_uc002uxv.1_Silent_p.I159I|CASP8_uc002uxw.1_Silent_p.I159I|CASP8_uc002uxy.1_Silent_p.I159I|CASP8_uc002uxx.1_Silent_p.I159I|CASP8_uc010ftf.2_Silent_p.I159I|CASP8_uc010fte.1_Silent_p.I56I	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	159	DED 2.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						AGTTGGACATCCTGAAAAGAG	0.438000										HNSCC(4;0.00038)		
ProSAPiP1	9762	broad.mit.edu	37	20	3146981	3146981	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr20:3146981G>A	uc002wia.1	-	2	1883	c.485C>T	c.(484-486)TCG>TTG	p.S162L	ProSAPiP1_uc002wib.1_Missense_Mutation_p.S162L	NM_014731	NP_055546	O60299	PRIP1_HUMAN	ProSAPiP1 protein	162						cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				pancreas(1)	1						CTTGAAGGCCGACGGCCGAAC	0.627000												
JAG1	182	broad.mit.edu	37	20	10626625	10626625	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr20:10626625C>T	uc002wnw.2	-	15	2509	c.1993G>A	c.(1993-1995)GAA>AAA	p.E665K	JAG1_uc010gcd.1_Missense_Mutation_p.E223K	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	665	Extracellular (Potential).|EGF-like 11; calcium-binding (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						TCACTGGTTTCACAGTAGGCC	0.512000									Alagille_Syndrome			
C20orf26	26074	broad.mit.edu	37	20	20144800	20144800	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr20:20144800G>A	uc002wru.2	+	11	1209	c.1133G>A	c.(1132-1134)CGC>CAC	p.R378H	C20orf26_uc010gcw.1_Missense_Mutation_p.R332H|C20orf26_uc010zse.1_Missense_Mutation_p.R378H|C20orf26_uc010zsf.1_Missense_Mutation_p.R378H	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	378										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		GTCCACTTCCGCCCCATCTAC	0.498000												
C20orf185	359710	broad.mit.edu	37	20	31644485	31644485	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr20:31644485G>A	uc002wym.1	+	2	262	c.262G>A	c.(262-264)GTT>ATT	p.V88I		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	88	Leu-rich.				innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						GGTTTTTGGCGTTGTCGAGGA	0.577000												
CYP24A1	1591	broad.mit.edu	37	20	52773733	52773733	+	Silent	SNP	C	C	T	rs150155645		TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr20:52773733C>T	uc002xwv.2	-	11	1928	c.1530G>A	c.(1528-1530)GCG>GCA	p.A510A	CYP24A1_uc002xwu.1_Silent_p.A368A|CYP24A1_uc002xww.2_Silent_p.A444A	NM_000782	NP_000773	Q07973	CP24A_HUMAN	cytochrome P450 family 24 subfamily A	510					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	GCTGGCAAAACGCGATGGGGA	0.428000												
OLIG2	10215	broad.mit.edu	37	21	34399178	34399178	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr21:34399178C>T	uc002yqx.1	+	2	166	c.8C>T	c.(7-9)TCG>TTG	p.S3L		NM_005806	NP_005797	Q13516	OLIG2_HUMAN	oligodendrocyte lineage transcription factor 2	3						cytoplasm|nucleus|plasma membrane	DNA binding			central_nervous_system(2)	2						GCCATGGACTCGGACGCCAGC	0.582000			T	TRA@	T-ALL							
DIP2A	23181	broad.mit.edu	37	21	47918652	47918652	+	Silent	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr21:47918652G>A	uc002zjo.2	+	5	744	c.561G>A	c.(559-561)CCG>CCA	p.P187P	DIP2A_uc011afy.1_Silent_p.P123P|DIP2A_uc011afz.1_Silent_p.P187P|DIP2A_uc002zjl.2_Silent_p.P187P|DIP2A_uc002zjm.2_Silent_p.P187P|DIP2A_uc010gql.2_Silent_p.P187P|DIP2A_uc002zjn.2_Silent_p.P187P	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	187					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CATCTCACCCGGGAGGGAGAC	0.672000												
SNAP29	9342	broad.mit.edu	37	22	21224688	21224688	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr22:21224688G>A	uc011ahw.1	+	2	408	c.301G>A	c.(301-303)GAT>AAT	p.D101N		NM_004782	NP_004773	O95721	SNP29_HUMAN	synaptosomal-associated protein 29	101	Potential.				cellular membrane fusion|exocytosis|protein transport|vesicle targeting	cell junction|cytoplasm|nucleus|synapse|synaptosome	SNAP receptor activity				0	all_cancers(11;2.77e-25)|all_epithelial(7;8.92e-24)|Lung NSC(8;1.49e-15)|all_lung(8;2.54e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000592)|Lung(15;0.0117)			GATGGACCAAGATTTGAAGAT	0.507000												
CBX6	23466	broad.mit.edu	37	22	39262882	39262882	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr22:39262882C>T	uc003awl.2	-	5	634	c.571G>A	c.(571-573)GGG>AGG	p.G191R		NM_014292	NP_055107	O95503	CBX6_HUMAN	chromobox homolog 6	191					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex					0	Melanoma(58;0.04)					gccccctgcccggcgcccccg	0.453000												
C3orf31	132001	broad.mit.edu	37	3	11880697	11880697	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr3:11880697G>A	uc003bwh.2	-	3	652	c.410C>T	c.(409-411)CCG>CTG	p.P137L	C3orf31_uc003bwj.2_Missense_Mutation_p.P137L|C3orf31_uc003bwi.2_RNA|C3orf31_uc011auo.1_Missense_Mutation_p.P137L|C3orf31_uc011aup.1_RNA|C3orf31_uc010hdy.1_RNA	NM_138807	NP_620162	Q96BW9	MMP37_HUMAN	MMP37-like protein, mitochondrial precursor	137					protein import into mitochondrial matrix	extrinsic to mitochondrial inner membrane					0						aacaCTCACCGGTTTTTGGAG	0.209000												
RHOA	387	broad.mit.edu	37	3	49405963	49405963	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr3:49405963C>A	uc003cwu.2	-	3	451	c.175G>T	c.(175-177)GAC>TAC	p.D59Y	RHOA_uc010hku.2_5'UTR	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	59	GTP (By similarity).				axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	CCAGCTGTGTCCCACAAAGCC	0.463000												
RHOA	387	broad.mit.edu	37	3	49412898	49412898	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr3:49412898T>G	uc003cwu.2	-	2	401	c.125A>C	c.(124-126)TAT>TCT	p.Y42S	RHOA_uc010hku.2_5'UTR	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	42	Effector region (Potential).				axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	ATCTGCCACATAGTTCTCAAA	0.433000												
FAM19A4	151647	broad.mit.edu	37	3	68934432	68934432	+	Translation_Start_Site	SNP	G	G	A	rs76914752	byFrequency	TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr3:68934432G>A	uc003dnh.1	-	2	351	c.-92C>T	c.(-94--90)AACGG>AATGG		FAM19A4_uc003dni.1_Translation_Start_Site	NM_182522	NP_872328	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine							extracellular region				skin(2)	2		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		CATTTCTGCCGTTCCAAAAAA	0.333000												
BOC	91653	broad.mit.edu	37	3	112998786	112998786	+	Silent	SNP	C	C	T	rs147219655		TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr3:112998786C>T	uc003dzx.2	+	13	2757	c.2136C>T	c.(2134-2136)CCC>CCT	p.P712P	BOC_uc003dzy.2_Silent_p.P712P|BOC_uc003dzz.2_Silent_p.P713P|BOC_uc003eab.2_Silent_p.P413P|BOC_uc003eac.2_Silent_p.P27P	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	712	Fibronectin type-III 3.|Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			ACGAGAGGCCCGTGGCAGGTC	0.627000												
SENP2	59343	broad.mit.edu	37	3	185335332	185335332	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr3:185335332C>T	uc003fpn.2	+	12	1346	c.1175C>T	c.(1174-1176)GCT>GTT	p.A392V	SENP2_uc011brv.1_Missense_Mutation_p.A382V|SENP2_uc011brw.1_Missense_Mutation_p.A205V	NM_021627	NP_067640	Q9HC62	SENP2_HUMAN	SUMO1/sentrin/SMT3 specific protease 2	392					mRNA transport|protein desumoylation|protein transport|proteolysis|regulation of Wnt receptor signaling pathway|transmembrane transport|Wnt receptor signaling pathway	cytoplasm|nuclear membrane|nuclear pore	protein binding|SUMO-specific protease activity				0	all_cancers(143;1.28e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			CTAAGTAGTGCTTTCAAATTG	0.388000												
PDCL2	132954	broad.mit.edu	37	4	56448359	56448359	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr4:56448359C>T	uc003hbb.2	-	2	155	c.52G>A	c.(52-54)GGC>AGC	p.G18S		NM_152401	NP_689614	Q8N4E4	PDCL2_HUMAN	phosducin-like 2	18											0	Lung NSC(11;0.00256)|Glioma(25;0.08)|all_epithelial(27;0.0863)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.69e-07)|Lung(4;1.03e-06)|Epithelial(7;0.00669)			GGAAGAATGCCGAAATCTCTT	0.338000												
ENPEP	2028	broad.mit.edu	37	4	111398070	111398070	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr4:111398070A>C	uc003iab.3	+	1	842	c.500A>C	c.(499-501)GAG>GCG	p.E167A		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	167	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	AAAAAGCAGGAGTACGTGGTG	0.627000												
DNAH5	1767	broad.mit.edu	37	5	13885264	13885264	+	Silent	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr5:13885264C>T	uc003jfd.2	-	19	2859	c.2817G>A	c.(2815-2817)ACG>ACA	p.T939T		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	939	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCGTGACTGTCGTCAAAAGCA	0.418000									Kartagener_syndrome			
PCDHB3	56132	broad.mit.edu	37	5	140481829	140481829	+	Silent	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr5:140481829C>T	uc003lio.2	+	1	1596	c.1596C>T	c.(1594-1596)GGC>GGT	p.G532G	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	532	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCGCGTGGGCGCCACAGACC	0.672000												
PCDHB7	56129	broad.mit.edu	37	5	140554097	140554097	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr5:140554097G>A	uc003lit.2	+	1	1855	c.1681G>A	c.(1681-1683)GTG>ATG	p.V561M		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	561	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCGCCCTTCGTGCTGTACCC	0.731000												
PCDHB11	56125	broad.mit.edu	37	5	140579705	140579705	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr5:140579705G>A	uc003liy.2	+	1	358	c.358G>A	c.(358-360)GAG>AAG	p.E120K	PCDHB11_uc011daj.1_Intron	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	120	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTACAAATTGAGCTTCAGGT	0.463000												
GMDS	2762	broad.mit.edu	37	6	1961067	1961067	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr6:1961067C>T	uc003mtq.2	-	5	669	c.479G>A	c.(478-480)GGG>GAG	p.G160E		NM_001500	NP_001491	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	160					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity			central_nervous_system(1)	1	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		CTGCACTTTCCCATAAAGTTC	0.498000												
HIST1H1A	3024	broad.mit.edu	37	6	26017492	26017492	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr6:26017492T>C	uc003nfo.2	-	1	549	c.469A>G	c.(469-471)AAA>GAA	p.K157E		NM_005325	NP_005316	Q02539	H11_HUMAN	histone cluster 1, H1a	157					nucleosome assembly|spermatogenesis	nucleosome|nucleus	DNA binding			ovary(2)	2						GCAGGCTTTTTAGCCTTTTTC	0.453000												
AKAP12	9590	broad.mit.edu	37	6	151670244	151670244	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr6:151670244G>A	uc011eep.1	+	4	958	c.718G>A	c.(718-720)GAA>AAA	p.E240K	AKAP12_uc003qoe.2_Missense_Mutation_p.E240K|AKAP12_uc003qof.2_Missense_Mutation_p.E142K|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.E135K	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	240			E -> K (in a colorectal cancer sample; somatic mutation).		G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding	p.E240K(1)		large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		AGAGAAACCCGAAGAGACCCT	0.557000												
EGFR	1956	broad.mit.edu	37	7	55211010	55211010	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr7:55211010G>A	uc003tqk.2	+	3	499	c.253G>A	c.(253-255)GTG>ATG	p.V85M	EGFR_uc003tqh.2_Missense_Mutation_p.V85M|EGFR_uc003tqi.2_Missense_Mutation_p.V85M|EGFR_uc003tqj.2_Missense_Mutation_p.V85M|EGFR_uc010kzg.1_Missense_Mutation_p.V85M|EGFR_uc011kco.1_Missense_Mutation_p.V32M	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	85	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CATCCAGGAGGTGGCTGGTTA	0.448000		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)		
ZNF479	90827	broad.mit.edu	37	7	57187764	57187764	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr7:57187764G>A	uc010kzo.2	-	5	1629	c.1358C>T	c.(1357-1359)ACT>ATT	p.T453I		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	453	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			CTTGTGGTCAGTGAGGGTTGA	0.428000												
TRRAP	8295	broad.mit.edu	37	7	98550831	98550831	+	Silent	SNP	G	G	C			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr7:98550831G>C	uc003upp.2	+	39	5693	c.5484G>C	c.(5482-5484)CTG>CTC	p.L1828L	TRRAP_uc011kis.1_Silent_p.L1810L|TRRAP_uc003upr.2_Silent_p.L1527L	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1828					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGGACTCGCTGCGGATCTACC	0.602000												
PLXNA4	91584	broad.mit.edu	37	7	131878892	131878892	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr7:131878892A>G	uc003vra.3	-	14	3014	c.2785T>C	c.(2785-2787)TTC>CTC	p.F929L		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	929	IPT/TIG 1.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						ATCTCCACGAAGCCTGCATGC	0.582000												
TRPV6	55503	broad.mit.edu	37	7	142569461	142569461	+	Silent	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr7:142569461C>T	uc003wbx.1	-	15	2393	c.2177G>A	c.(2176-2178)TGA>TAA	p.*726*	TRPV6_uc003wbw.1_Silent_p.*512*|TRPV6_uc010lou.1_Silent_p.*597*	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	726					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					AACACGCAGTCAGATCTGATA	0.532000												
ADRA1A	148	broad.mit.edu	37	8	26627887	26627887	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr8:26627887C>T	uc003xfh.1	-	2	1616	c.1180G>A	c.(1180-1182)GTT>ATT	p.V394I	ADRA1A_uc003xfc.1_Missense_Mutation_p.V394I|ADRA1A_uc010lul.1_Intron|ADRA1A_uc003xfd.1_Intron|ADRA1A_uc003xfe.1_Missense_Mutation_p.V394I|ADRA1A_uc010lum.1_Intron|ADRA1A_uc003xff.1_Intron|ADRA1A_uc003xfg.1_Missense_Mutation_p.V394I	NM_000680	NP_000671	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 1	394	Cytoplasmic (By similarity).				activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	CATTCACAAACGCCATCCGTC	0.552000												
RP1	6101	broad.mit.edu	37	8	55539912	55539912	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr8:55539912C>T	uc003xsd.1	+	4	3618	c.3470C>T	c.(3469-3471)TCT>TTT	p.S1157F	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1157					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ACCAACAAATCTTCAGAAACA	0.418000												
RUNX1T1	862	broad.mit.edu	37	8	93004103	93004103	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr8:93004103C>T	uc003yfd.2	-	6	839	c.755G>A	c.(754-756)GGC>GAC	p.G252D	RUNX1T1_uc003yfc.1_Missense_Mutation_p.G225D|RUNX1T1_uc003yfe.1_Missense_Mutation_p.G215D|RUNX1T1_uc010mao.2_Missense_Mutation_p.G225D|RUNX1T1_uc011lgi.1_Missense_Mutation_p.G263D|RUNX1T1_uc010man.1_5'UTR|RUNX1T1_uc003yfb.1_Missense_Mutation_p.G215D	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	252					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TCTGTCAAAGCCATTTTCTTT	0.433000												
TAF1L	138474	broad.mit.edu	37	9	32630240	32630240	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr9:32630240C>T	uc003zrg.1	-	1	5428	c.5338G>A	c.(5338-5340)GAA>AAA	p.E1780K		NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1780					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TCTCCTTCTTCGTCACTCCCA	0.453000												
PGM5	5239	broad.mit.edu	37	9	71002420	71002420	+	Missense_Mutation	SNP	C	C	T	rs138311393		TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr9:71002420C>T	uc004agr.2	+	4	842	c.613C>T	c.(613-615)CGG>TGG	p.R205W		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	205					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						TAACCTCCTTCGGACCATCTT	0.428000												
PHEX	5251	broad.mit.edu	37	X	22263519	22263519	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chrX:22263519C>T	uc004dah.2	+	21	2343	c.2140C>T	c.(2140-2142)CAG>TAG	p.Q714*	PHEX_uc011mjr.1_Intron|PHEX_uc011mjs.1_Nonsense_Mutation_p.Q617*	NM_000444	NP_000435	P78562	PHEX_HUMAN	phosphate-regulating neutral endopeptidase	714					biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3						CAGTCCCCCTCAGTTTAGGTA	0.512000												
DMD	1756	broad.mit.edu	37	X	31792190	31792190	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chrX:31792190G>A	uc004dda.1	-	51	7673	c.7429C>T	c.(7429-7431)CGG>TGG	p.R2477W	DMD_uc004dcr.1_Missense_Mutation_p.R17W|DMD_uc004dcs.1_Missense_Mutation_p.R17W|DMD_uc004dct.1_Missense_Mutation_p.R17W|DMD_uc004dcu.1_Missense_Mutation_p.R17W|DMD_uc004dcv.1_Missense_Mutation_p.R17W|DMD_uc004dcw.2_Missense_Mutation_p.R1133W|DMD_uc004dcx.2_Missense_Mutation_p.R1136W|DMD_uc004dcz.2_Missense_Mutation_p.R2354W|DMD_uc004dcy.1_Missense_Mutation_p.R2473W|DMD_uc004ddb.1_Missense_Mutation_p.R2469W|DMD_uc004ddd.1_Missense_Mutation_p.R17W	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2477	Spectrin 17.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GTCCAAGCCCGGTTGAAATCT	0.463000												
MAGEE2	139599	broad.mit.edu	37	X	75004703	75004703	+	Missense_Mutation	SNP	C	C	A	rs142989384		TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chrX:75004703C>A	uc004ecj.1	-	1	369	c.184G>T	c.(184-186)GTT>TTT	p.V62F		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	62										ovary(1)|skin(1)	2						GGGTCCTGAACGGCCTGGGAA	0.592000												
DCAF12L1	139170	broad.mit.edu	37	X	125685294	125685294	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chrX:125685294G>A	uc004eul.2	-	1	1549	c.1298C>T	c.(1297-1299)ACC>ATC	p.T433I		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	433										skin(3)|ovary(1)	4						GTAGCAGTGGGTGTAGAGCGC	0.552000												
UBE2NL	389898	broad.mit.edu	37	X	142967424	142967424	+	Silent	SNP	C	C	A			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chrX:142967424C>A	uc004fca.2	+	1	252	c.222C>A	c.(220-222)ACC>ACA	p.T74T		NM_001012989	NP_001013007	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	74							acid-amino acid ligase activity				0	Acute lymphoblastic leukemia(192;6.56e-05)					GTTTCATGACCAAAATTTATC	0.413000												
F8	2157	broad.mit.edu	37	X	154197692	154197692	+	Missense_Mutation	SNP	G	G	A	rs137852404		TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chrX:154197692G>A	uc004fmt.2	-	7	1094	c.923C>T	c.(922-924)TCG>TTG	p.S308L		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	308	Plastocyanin-like 2.|F5/8 type A 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	AGTTATTGGCGAGATTTCCAA	0.448000												
ZNF329	79673	broad.mit.edu	37	19	58640848	58640850	+	In_Frame_Del	DEL	CGA	CGA	-			TCGA-D7-6521-01A-11D-1800-08	TCGA-D7-6521-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af27d5e0-d709-4e53-949d-cd7cd7bfb970	9f181c29-67a5-43b4-afc3-eaf51936888d	g.chr19:58640847_58640849CCGA>C	uc002qrn.3	-	3	259_261	c.22_24TCGG>G	c.(22-24)cgg>G	p.R8del	ZNF329_uc010euk.1_Non-coding_Transcript|ZNF329_uc002qro.1_Non-coding_Transcript|ZNF329_uc002qrp.1_Non-coding_Transcript|ZNF329_uc021vcv.1_In_Frame_Del_p.R8del	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	Homo sapiens zinc finger protein 329 (ZNF329), mRNA.	8					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R8W(2)		NS(1)|large_intestine(10)|lung(5)|skin(3)|urinary_tract(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		CAGGAAAATTCCGAGTCGTCATT	0.399												
