Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
HSPG2	3339	broad.mit.edu	37	1	22165524	22165524	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:22165524G>A	uc001bfj.2	-	74	9984	c.9944C>T	c.(9943-9945)ACG>ATG	p.T3315M	HSPG2_uc009vqd.2_Missense_Mutation_p.T3316M	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	3315	Ig-like C2-type 19.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GAGCTGCACCGTCTCCCCTGC	0.672												
EIF3I	8668	broad.mit.edu	37	1	32689716	32689716	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:32689716G>A	uc001bur.3	+	4	711	c.178G>A	c.(178-180)GCT>ACT	p.A60T	C1orf91_uc001buo.3_5'Flank|C1orf91_uc001bup.3_5'Flank|C1orf91_uc009vub.1_5'Flank|C1orf91_uc010oha.1_5'Flank|C1orf91_uc001buq.3_5'Flank|EIF3I_uc009vuc.2_Missense_Mutation_p.A60T|EIF3I_uc001bus.2_Missense_Mutation_p.A12T	NM_003757	NP_003748	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3,	60	WD 2.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				GTGTGTGGACGCTGACTGTAT	0.537												
CSMD2	114784	broad.mit.edu	37	1	34158580	34158580	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:34158580G>T	uc001bxn.1	-	25	3911	c.3882C>A	c.(3880-3882)CAC>CAA	p.H1294Q	CSMD2_uc001bxm.1_Missense_Mutation_p.H1334Q|CSMD2_uc001bxo.1_Missense_Mutation_p.H207Q	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1294	CUB 8.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AGTTGAGATTGTGTTCATAGG	0.552												
PDE4B	5142	broad.mit.edu	37	1	66827323	66827323	+	Silent	SNP	A	A	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:66827323A>C	uc001dcn.2	+	10	1058	c.867A>C	c.(865-867)CCA>CCC	p.P289P	PDE4B_uc009war.2_Silent_p.P197P|PDE4B_uc001dco.2_Silent_p.P289P|PDE4B_uc001dcp.2_Silent_p.P274P|PDE4B_uc001dcq.2_Silent_p.P117P|PDE4B_uc009was.2_Silent_p.P56P	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	289					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	TGGAGATCCCATCTCCTACCC	0.393												
LRRC7	57554	broad.mit.edu	37	1	70488966	70488966	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:70488966G>C	uc001dep.2	+	15	1619	c.1589G>C	c.(1588-1590)TGT>TCT	p.C530S	LRRC7_uc009wbg.2_Intron	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	530						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						GCATGGGGTTGTATAAGTGGC	0.557												
IFI44L	10964	broad.mit.edu	37	1	79093853	79093853	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:79093853T>C	uc010oro.1	+	2	432	c.253T>C	c.(253-255)TTT>CTT	p.F85L	IFI44L_uc010orp.1_Intron|IFI44L_uc010orq.1_Intron	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	85						cytoplasm					0						TTCCCTATGGTTTTCACTTCA	0.313												
BARHL2	343472	broad.mit.edu	37	1	91180275	91180275	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:91180275G>A	uc001dns.2	-	2	706	c.664C>T	c.(664-666)CGT>TGT	p.R222C		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	222						nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		GGACTCTCACGGCTACTCGTA	0.542												
GFI1	2672	broad.mit.edu	37	1	92946367	92946367	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:92946367C>T	uc001dou.3	-	4	741	c.577G>A	c.(577-579)GCT>ACT	p.A193T	GFI1_uc001dov.3_Missense_Mutation_p.A193T|GFI1_uc001dow.3_Missense_Mutation_p.A193T	NM_001127215	NP_001120687	Q99684	GFI1_HUMAN	growth factor independent 1	193	Ala/Gly-rich.				negative regulation of calcidiol 1-monooxygenase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription, DNA-dependent|viral reproduction	nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)	1		all_lung(203;0.00292)|Lung NSC(277;0.0115)|all_neural(321;0.185)|Glioma(108;0.203)		OV - Ovarian serous cystadenocarcinoma(397;9.04e-07)|Epithelial(280;1.17e-05)|all cancers(265;5.61e-05)|GBM - Glioblastoma multiforme(16;0.0191)		CCAGGGCCAGCGGTGGCACCG	0.652												
AMY2B	280	broad.mit.edu	37	1	104122108	104122108	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:104122108G>A	uc001duq.2	+	12	2138	c.1522G>A	c.(1522-1524)GAA>AAA	p.E508K	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.E508K|AMY2B_uc001dus.1_Intron	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	508					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		AATTCATGCTGAATCtaaatt	0.294												
CA14	23632	broad.mit.edu	37	1	150230572	150230572	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:150230572G>A	uc001etx.2	+	1	358	c.49G>A	c.(49-51)GAT>AAT	p.D17N	CA14_uc009wln.2_Missense_Mutation_p.D17N	NM_012113	NP_036245	Q9ULX7	CAH14_HUMAN	carbonic anhydrase XIV precursor	17	Extracellular (Potential).					integral to membrane	carbonate dehydratase activity|metal ion binding			ovary(1)	1	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCTGGCTGCAGATGGGGGTAG	0.532												
FLG	2312	broad.mit.edu	37	1	152277297	152277297	+	Silent	SNP	C	C	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:152277297C>A	uc001ezu.1	-	3	10101	c.10065G>T	c.(10063-10065)GTG>GTT	p.V3355V		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3355	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGGCCTGACACTGACTGTG	0.572									Ichthyosis			
OR6K3	391114	broad.mit.edu	37	1	158687131	158687131	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:158687131A>C	uc010pip.1	-	1	823	c.823T>G	c.(823-825)TTG>GTG	p.L275V		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	275	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					CTGAAACGCAAGTACATGAGT	0.463												
FCER1A	2205	broad.mit.edu	37	1	159272174	159272174	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:159272174C>T	uc001ftq.2	+	2	119	c.20C>T	c.(19-21)TCC>TTC	p.S7F		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	7						integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	GCCATGGAATCCCCTACTCTA	0.483												
C1orf129	80133	broad.mit.edu	37	1	170965696	170965696	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:170965696A>C	uc001ghg.2	+	14	1516	c.1386A>C	c.(1384-1386)CAA>CAC	p.Q462H	C1orf129_uc009wvy.2_Missense_Mutation_p.Q269H|C1orf129_uc010plz.1_Missense_Mutation_p.Q462H	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	462							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTGGACTGCAACAGGTGGATA	0.423												
DNM3	26052	broad.mit.edu	37	1	171810859	171810859	+	Silent	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:171810859G>A	uc001gie.2	+	1	239	c.63G>A	c.(61-63)TCG>TCA	p.S21S	DNM3_uc001gid.3_Silent_p.S21S|DNM3_uc009wwb.2_Silent_p.S21S|DNM3_uc001gif.2_Silent_p.S21S	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	21					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						ACGCGTTTTCGGCGCTGGGAC	0.687												
CFH	3075	broad.mit.edu	37	1	196716354	196716354	+	Missense_Mutation	SNP	C	C	T	rs145347741	byFrequency	TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:196716354C>T	uc001gtj.3	+	22	3847	c.3607C>T	c.(3607-3609)CGG>TGG	p.R1203W		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	1203	Sushi 20.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TGTGTGTAAACGGGGATATCG	0.383												
WNT3A	89780	broad.mit.edu	37	1	228246694	228246694	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:228246694C>T	uc001hrq.1	+	4	665	c.587C>T	c.(586-588)GCC>GTC	p.A196V	WNT3A_uc001hrp.1_Missense_Mutation_p.A196V	NM_033131	NP_149122	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family,	196					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			ovary(1)	1		Prostate(94;0.0405)				CAGGCCATCGCCAGCCACATG	0.667												
OR2W5	441932	broad.mit.edu	37	1	247654765	247654765	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:247654765C>T	uc001icz.1	+	1	336	c.336C>T	c.(334-336)TGC>TGT	p.C112C		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CCACCGAGTGCGTCCTCCTGG	0.602												
OR2T12	127064	broad.mit.edu	37	1	248458139	248458139	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr1:248458139G>T	uc010pzj.1	-	1	742	c.742C>A	c.(742-744)CTC>ATC	p.L248I		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	248	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			CCATAAAAGAGTCCCACCACA	0.507												
DIP2C	22982	broad.mit.edu	37	10	428632	428632	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr10:428632C>T	uc001ifp.2	-	17	2036	c.1946G>A	c.(1945-1947)TGT>TAT	p.C649Y	DIP2C_uc009xhj.1_Missense_Mutation_p.C345Y	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	649						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GGCACAAGGACAGATGACCTC	0.488												
ITIH5	80760	broad.mit.edu	37	10	7679382	7679382	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr10:7679382G>A	uc001ijq.2	-	5	540	c.461C>T	c.(460-462)GCC>GTC	p.A154V	ITIH5_uc001ijr.1_Missense_Mutation_p.A154V	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	154	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						CAGGAAAAAGGCGGCTTTGTC	0.567												
MAP3K8	1326	broad.mit.edu	37	10	30749642	30749642	+	Silent	SNP	G	G	A	rs150841663		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr10:30749642G>A	uc001ivi.1	+	9	1977	c.1281G>A	c.(1279-1281)TCG>TCA	p.S427S	MAP3K8_uc009xlf.1_Silent_p.S427S|MAP3K8_uc001ivj.1_Silent_p.S427S	NM_005204	NP_005195	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase	427			Missing (in oncogenic form).		cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(3)|central_nervous_system(1)	4		Prostate(175;0.151)				CAGATTCTTCGTGCACAGGAA	0.453												
PCDH15	65217	broad.mit.edu	37	10	55955568	55955568	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr10:55955568A>G	uc001jju.1	-	11	1575	c.1180T>C	c.(1180-1182)TAT>CAT	p.Y394H	PCDH15_uc010qhq.1_Missense_Mutation_p.Y399H|PCDH15_uc010qhr.1_Missense_Mutation_p.Y394H|PCDH15_uc010qhs.1_Missense_Mutation_p.Y399H|PCDH15_uc010qht.1_Missense_Mutation_p.Y394H|PCDH15_uc010qhu.1_Missense_Mutation_p.Y394H|PCDH15_uc001jjv.1_Missense_Mutation_p.Y372H|PCDH15_uc010qhv.1_Missense_Mutation_p.Y394H|PCDH15_uc010qhw.1_Missense_Mutation_p.Y357H|PCDH15_uc010qhx.1_Missense_Mutation_p.Y394H|PCDH15_uc010qhy.1_Missense_Mutation_p.Y399H|PCDH15_uc010qhz.1_Missense_Mutation_p.Y394H|PCDH15_uc010qia.1_Missense_Mutation_p.Y372H|PCDH15_uc010qib.1_Missense_Mutation_p.Y372H|PCDH15_uc001jjw.2_Missense_Mutation_p.Y394H	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	394	Cadherin 3.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ATTGTAAAATATGGACTTTGA	0.403										HNSCC(58;0.16)		
TET1	80312	broad.mit.edu	37	10	70450715	70450715	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr10:70450715C>T	uc001jok.3	+	12	6060	c.5555C>T	c.(5554-5556)CCG>CTG	p.P1852L		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1852					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TCCTGGTCCCCGAAGACTGCT	0.502												
CRTAC1	55118	broad.mit.edu	37	10	99770980	99770980	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr10:99770980A>G	uc001kou.1	-	2	495	c.139T>C	c.(139-141)TAT>CAT	p.Y47H	CRTAC1_uc001kov.2_Missense_Mutation_p.Y36H	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	47	FG-GAP 1; atypical.					proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		TTACTGTCATAGTCAGGAGGC	0.562												
NOLC1	9221	broad.mit.edu	37	10	103919306	103919306	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr10:103919306A>C	uc001kuo.2	+	7	1075	c.840A>C	c.(838-840)AAA>AAC	p.K280N	NOLC1_uc001kup.2_Missense_Mutation_p.K290N|NOLC1_uc001kuq.2_Missense_Mutation_p.K281N|NOLC1_uc009xxb.1_5'UTR|NOLC1_uc001kur.2_5'UTR	NM_004741	NP_004732	Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	280	11 X 12 AA approximate repeats of an acidic serine cluster.|Interacts with RPA194.				mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		AGCAAAAAAAACCCATGAAAA	0.323												
C10orf96	374355	broad.mit.edu	37	10	118084562	118084562	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr10:118084562C>T	uc001lck.2	+	2	290	c.39C>T	c.(37-39)ACC>ACT	p.T13T		NM_198515	NP_940917	P0C7W6	CJ096_HUMAN	hypothetical protein LOC374355	13	Potential.									ovary(2)	2		Lung NSC(174;0.204)|all_lung(145;0.248)		all cancers(201;0.014)		TCATCTTCACCGAGCATCAGG	0.522												
TH	7054	broad.mit.edu	37	11	2185600	2185600	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr11:2185600G>A	uc001lvq.2	-	14	1469	c.1450C>T	c.(1450-1452)CGC>TGC	p.R484C	TH_uc001lvp.2_Missense_Mutation_p.R480C|TH_uc001lvr.2_Missense_Mutation_p.R453C|TH_uc010qxj.1_Missense_Mutation_p.R457C|TH_uc001lvs.2_Missense_Mutation_p.R359C|TH_uc001lvt.2_Missense_Mutation_p.R363C	NM_199292	NP_954986	P07101	TY3H_HUMAN	tyrosine hydroxylase isoform a	484					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity				0		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	GAGAAGGGGCGCTGGATGCGT	0.687												
UBQLN3	50613	broad.mit.edu	37	11	5530452	5530452	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr11:5530452T>C	uc001may.1	-	2	423	c.337A>G	c.(337-339)AGT>GGT	p.S113G	HBG2_uc001mak.1_Intron	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	113										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATCCAGGACTTGGGCCCTGG	0.612												
UBQLNL	143630	broad.mit.edu	37	11	5537480	5537480	+	Silent	SNP	T	T	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr11:5537480T>C	uc001maz.3	-	1	477	c.192A>G	c.(190-192)CAA>CAG	p.Q64Q	HBG2_uc001mak.1_Intron	NM_145053	NP_659490	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	64	Ubiquitin-like.									large_intestine(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		CCATCTGGCATTGGAAGTGAG	0.498												
ANO3	63982	broad.mit.edu	37	11	26581277	26581277	+	Silent	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr11:26581277G>A	uc001mqt.3	+	14	1543	c.1398G>A	c.(1396-1398)TTG>TTA	p.L466L	ANO3_uc010rdr.1_Silent_p.L450L|ANO3_uc010rds.1_Silent_p.L305L|ANO3_uc010rdt.1_Silent_p.L320L|MUC15_uc001mqw.2_3'UTR|MUC15_uc001mqx.2_3'UTR|MUC15_uc001mqy.2_3'UTR	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	466	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TGACATATTTGTTCGATAATG	0.328												
OR4C16	219428	broad.mit.edu	37	11	55340006	55340006	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr11:55340006A>C	uc010rih.1	+	1	403	c.403A>C	c.(403-405)AGC>CGC	p.S135R		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				GACCATCATAAGCCAGTGGGT	0.507												
OR4P4	81300	broad.mit.edu	37	11	55406228	55406228	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr11:55406228T>G	uc010rij.1	+	1	395	c.395T>G	c.(394-396)ATT>AGT	p.I132S		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	132	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						CACTACACCATTATTATGAGC	0.433												
OR5T2	219464	broad.mit.edu	37	11	55999981	55999981	+	Silent	SNP	A	A	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr11:55999981A>C	uc010rjc.1	-	1	681	c.681T>G	c.(679-681)TCT>TCG	p.S227S		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	227	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TGTCAGAATAAGAAATAGCAA	0.423												
MS4A14	84689	broad.mit.edu	37	11	60184378	60184378	+	Missense_Mutation	SNP	C	C	A	rs145801550		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr11:60184378C>A	uc001npj.2	+	5	2502	c.1937C>A	c.(1936-1938)TCC>TAC	p.S646Y	MS4A14_uc001npi.2_Missense_Mutation_p.S534Y|MS4A14_uc001npn.2_Missense_Mutation_p.S384Y|MS4A14_uc001npk.2_Missense_Mutation_p.S629Y|MS4A14_uc001npl.2_Missense_Mutation_p.S384Y|MS4A14_uc001npm.2_Missense_Mutation_p.S384Y	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	646	Gln-rich.					integral to membrane	receptor activity			breast(1)	1						GATTCAGAATCCCAAATACAG	0.463												
DDB1	1642	broad.mit.edu	37	11	61079287	61079287	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr11:61079287G>A	uc001nrc.3	-	18	2472	c.2246C>T	c.(2245-2247)ACG>ATG	p.T749M	DDB1_uc010rle.1_Intron|DDB1_uc010rlf.1_Missense_Mutation_p.T749M	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	749	Interaction with CDT1.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						CAAGGCTGTCGTGCCCCCACT	0.463								NER				
PCNXL3	399909	broad.mit.edu	37	11	65387389	65387389	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr11:65387389T>G	uc001oey.2	+	8	1994	c.1994T>G	c.(1993-1995)TTC>TGC	p.F665C		NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	665						integral to membrane					0						GTGCACTATTTCTACGATGAG	0.617												
P2RY6	5031	broad.mit.edu	37	11	73008084	73008084	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr11:73008084G>A	uc001otm.2	+	4	926	c.521G>A	c.(520-522)CGC>CAC	p.R174H	P2RY6_uc001otn.2_Missense_Mutation_p.R174H|P2RY6_uc001oto.2_Missense_Mutation_p.R174H|P2RY6_uc001otp.2_Missense_Mutation_p.R174H|P2RY6_uc001otq.2_Missense_Mutation_p.R174H|P2RY6_uc001otr.2_Missense_Mutation_p.R174H|P2RY6_uc001ots.2_Missense_Mutation_p.R174H	NM_176796	NP_789766	Q15077	P2RY6_HUMAN	pyrimidinergic receptor P2Y6	174	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1						CAGCGTAACCGCACTGTCTGC	0.637												
FUT4	2526	broad.mit.edu	37	11	94278700	94278700	+	Silent	SNP	C	C	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr11:94278700C>A	uc001pez.2	+	1	1684	c.1401C>A	c.(1399-1401)TCC>TCA	p.S467S	PIWIL4_uc010rue.1_Intron|PIWIL4_uc009ywk.1_5'Flank	NM_002033	NP_002024	P22083	FUT4_HUMAN	fucosyltransferase 4	467	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	alpha(1,3)-fucosyltransferase activity			skin(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GTGCCTCCTCCCTGGCCTCGT	0.667												
PGR	5241	broad.mit.edu	37	11	100933339	100933339	+	Missense_Mutation	SNP	A	A	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr11:100933339A>T	uc001pgh.2	-	4	2794	c.2051T>A	c.(2050-2052)ATT>AAT	p.I684N	PGR_uc001pgg.2_Missense_Mutation_p.I65N|PGR_uc001pgi.2_Intron|PGR_uc009yww.1_Intron|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	684	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CAGTGGTGGAATCAACTGTAT	0.468												
GUCY1A2	2977	broad.mit.edu	37	11	106810753	106810753	+	Silent	SNP	A	A	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr11:106810753A>G	uc001pjg.1	-	4	1029	c.639T>C	c.(637-639)TCT>TCC	p.S213S	GUCY1A2_uc010rvo.1_Silent_p.S213S|GUCY1A2_uc009yxn.1_Silent_p.S213S	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	213					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		GTTTTCCAAAAGAAGTTCTAA	0.453												
IL10RA	3587	broad.mit.edu	37	11	117866365	117866365	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr11:117866365C>T	uc001prv.2	+	6	827	c.750C>T	c.(748-750)CTC>CTT	p.L250L	IL10RA_uc010rxl.1_Silent_p.L230L|IL10RA_uc010rxm.1_Silent_p.L230L|IL10RA_uc010rxn.1_Silent_p.L101L|IL10RA_uc001prw.2_Silent_p.L101L	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	250	Helical; (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		CCGGAGCCCTCGCCTACTGCC	0.587												
CXCR5	643	broad.mit.edu	37	11	118765000	118765000	+	Silent	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr11:118765000G>A	uc001pue.3	+	2	857	c.747G>A	c.(745-747)CAG>CAA	p.Q249Q	CXCR5_uc001puf.2_Silent_p.Q204Q	NM_001716	NP_001707	P32302	CXCR5_HUMAN	Burkitt lymphoma receptor 1 isoform 1	249	Cytoplasmic (Potential).				B cell activation|cellular component movement	integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		GCCAGGCCCAGCGGCGCCCTC	0.617												
TECTA	7007	broad.mit.edu	37	11	120998532	120998532	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr11:120998532G>A	uc010rzo.1	+	8	1846	c.1846G>A	c.(1846-1848)GAC>AAC	p.D616N		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	616	TIL 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CACATGCTCCGACCTGACGGC	0.642												
OR8D4	338662	broad.mit.edu	37	11	123778075	123778075	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr11:123778075C>T	uc010saa.1	+	1	937	c.937C>T	c.(937-939)CCA>TCA	p.P313S		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	313	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		ATCTTTATCTCCAGGATAAAT	0.269												
CACNA1C	775	broad.mit.edu	37	12	2622033	2622033	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr12:2622033C>T	uc009zdu.1	+	9	1586	c.1273C>T	c.(1273-1275)CGG>TGG	p.R425W	CACNA1C_uc009zdv.1_Missense_Mutation_p.R422W|CACNA1C_uc001qkb.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkc.2_Missense_Mutation_p.R425W|CACNA1C_uc001qke.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkf.2_Missense_Mutation_p.R425W|CACNA1C_uc001qjz.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkd.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkg.2_Missense_Mutation_p.R425W|CACNA1C_uc009zdw.1_Missense_Mutation_p.R425W|CACNA1C_uc001qkh.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkl.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkn.2_Missense_Mutation_p.R425W|CACNA1C_uc001qko.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkp.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkr.2_Missense_Mutation_p.R425W|CACNA1C_uc001qku.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkq.2_Missense_Mutation_p.R425W|CACNA1C_uc001qks.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkt.2_Missense_Mutation_p.R425W|CACNA1C_uc001qka.1_Intron|CACNA1C_uc001qki.1_Missense_Mutation_p.R161W|CACNA1C_uc001qkj.1_Missense_Mutation_p.R161W|CACNA1C_uc001qkk.1_Missense_Mutation_p.R161W|CACNA1C_uc001qkm.1_Missense_Mutation_p.R161W|CACNA1C_uc009zdy.1_Missense_Mutation_p.R50W|CACNA1C_uc001qkv.1_5'UTR	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	425	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CCAGAAGCTGCGGGAGAAGCA	0.552												
TAS2R13	50838	broad.mit.edu	37	12	11061719	11061719	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr12:11061719C>A	uc001qzg.1	-	1	443	c.179G>T	c.(178-180)TGG>TTG	p.W60L	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron	NM_023920	NP_076409	Q9NYV9	T2R13_HUMAN	taste receptor, type 2, member 13	60	Helical; Name=2; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			breast(1)|skin(1)	2						TAATATTTCCCAGATCAGCCC	0.373												
PDE3A	5139	broad.mit.edu	37	12	20766614	20766614	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr12:20766614G>C	uc001reh.1	+	3	1271	c.1249G>C	c.(1249-1251)GAC>CAC	p.D417H		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	417					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CTCTGAAAAAGACAAGCTTGC	0.428												
SLCO1B3	28234	broad.mit.edu	37	12	21011495	21011495	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr12:21011495T>G	uc001rek.2	+	4	475	c.349T>G	c.(349-351)TTC>GTC	p.F117V	SLCO1B3_uc001rel.2_Missense_Mutation_p.F117V|SLCO1B3_uc010sil.1_Missense_Mutation_p.F117V|LST-3TM12_uc010sim.1_Missense_Mutation_p.F117V	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	117	Helical; Name=3; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					ACCACATTTCTTCATGGGATA	0.338												
PYROXD1	79912	broad.mit.edu	37	12	21602575	21602575	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr12:21602575T>C	uc001rew.2	+	4	491	c.364T>C	c.(364-366)TGT>CGT	p.C122R	PYROXD1_uc009ziq.2_5'UTR|PYROXD1_uc009zir.2_Intron	NM_024854	NP_079130	Q8WU10	PYRD1_HUMAN	pyridine nucleotide-disulphide oxidoreductase	122							oxidoreductase activity			ovary(1)	1						aaagttgatatgtgaaggaaa	0.259												
LRRK2	120892	broad.mit.edu	37	12	40714877	40714877	+	Missense_Mutation	SNP	A	A	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr12:40714877A>T	uc001rmg.3	+	35	5178	c.5057A>T	c.(5056-5058)GAG>GTG	p.E1686V	LRRK2_uc009zjw.2_Missense_Mutation_p.E524V|LRRK2_uc001rmi.2_Missense_Mutation_p.E519V	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1686					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CCCCATTGTGAGAACTCTGAA	0.398												
NR4A1	3164	broad.mit.edu	37	12	52448549	52448549	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr12:52448549T>G	uc001rzs.2	+	3	751	c.437T>G	c.(436-438)TTC>TGC	p.F146C	NR4A1_uc010sno.1_Missense_Mutation_p.F159C|NR4A1_uc001rzr.2_Missense_Mutation_p.F146C|NR4A1_uc009zmb.1_Missense_Mutation_p.F146C|NR4A1_uc001rzt.2_Missense_Mutation_p.F146C|NR4A1_uc009zmc.2_5'Flank	NM_002135	NP_002126	P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	146					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(357;0.0967)		ACGCCCAGCTTCCAGCCGCCC	0.687												
KRT3	3850	broad.mit.edu	37	12	53186067	53186067	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr12:53186067C>T	uc001say.2	-	5	1210	c.1144G>A	c.(1144-1146)GCT>ACT	p.A382T		NM_057088	NP_476429	P12035	K2C3_HUMAN	keratin 3	382	Rod.|Coil 2.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity				0						CTTCTCTGAGCGATATCCTCA	0.547												
OR6C6	283365	broad.mit.edu	37	12	55688654	55688654	+	Silent	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr12:55688654G>A	uc010sph.1	-	1	363	c.363C>T	c.(361-363)TAC>TAT	p.Y121Y		NM_001005493	NP_001005493	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|skin(1)	2						AGATGGCAACGTAGCGGTCAT	0.388												
KCNC2	3747	broad.mit.edu	37	12	75601257	75601257	+	Silent	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr12:75601257G>A	uc001sxg.1	-	2	1051	c.507C>T	c.(505-507)TTC>TTT	p.F169F	KCNC2_uc009zry.2_Silent_p.F169F|KCNC2_uc001sxe.2_Silent_p.F169F|KCNC2_uc001sxf.2_Silent_p.F169F|KCNC2_uc010stw.1_Silent_p.F169F	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	169	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						CGGGGGTCTCGAAGATGTCCA	0.721												
ACSS3	79611	broad.mit.edu	37	12	81532956	81532956	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr12:81532956G>T	uc001szl.1	+	4	783	c.692G>T	c.(691-693)AGG>ATG	p.R231M	ACSS3_uc001szm.1_Missense_Mutation_p.R230M	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	231						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CCTGGAAGGAGGGTAGAGTAC	0.348												
USP44	84101	broad.mit.edu	37	12	95927656	95927656	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr12:95927656C>T	uc001teg.2	-	2	521	c.377G>A	c.(376-378)GGT>GAT	p.G126D	USP44_uc001teh.2_Missense_Mutation_p.G126D|USP44_uc009zte.2_Missense_Mutation_p.G123D	NM_001042403	NP_001035862	Q9H0E7	UBP44_HUMAN	ubiquitin thiolesterase 44	126					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)|breast(1)|central_nervous_system(1)	3						AGAATCATCACCTGTACCCAT	0.428												
BTBD11	121551	broad.mit.edu	37	12	108013802	108013802	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr12:108013802G>A	uc001tmk.1	+	11	3013	c.2492G>A	c.(2491-2493)CGG>CAG	p.R831Q	BTBD11_uc009zut.1_Missense_Mutation_p.R712Q|BTBD11_uc001tmj.2_Missense_Mutation_p.R831Q|BTBD11_uc001tml.1_Missense_Mutation_p.R368Q	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	831	ANK 5.					integral to membrane	DNA binding			skin(2)|ovary(1)	3						GAGTCTTTGCGGATCGCCTTC	0.428												
ZCCHC8	55596	broad.mit.edu	37	12	122975087	122975087	+	Missense_Mutation	SNP	A	A	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr12:122975087A>T	uc001ucn.2	-	4	476	c.345T>A	c.(343-345)TTT>TTA	p.F115L	ZCCHC8_uc009zxp.2_5'UTR|ZCCHC8_uc009zxq.2_5'UTR	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	115						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		AATTTGATACAAATTCCTCTA	0.333												
TMEM132B	114795	broad.mit.edu	37	12	126139127	126139127	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr12:126139127C>T	uc001uhe.1	+	9	3116	c.3108C>T	c.(3106-3108)GAC>GAT	p.D1036D	TMEM132B_uc001uhf.1_Silent_p.D548D	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	1036	Cytoplasmic (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TCCCAGAGGACGGCGGCCCAT	0.473												
EFHA1	221154	broad.mit.edu	37	13	22095431	22095431	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr13:22095431G>C	uc001uof.2	-	6	572	c.550C>G	c.(550-552)CTG>GTG	p.L184V		NM_152726	NP_689939	Q8IYU8	EFHA1_HUMAN	EF-hand domain family, member A1	184	EF-hand 1.						calcium ion binding				0		all_cancers(29;1.24e-15)|all_epithelial(30;5.4e-14)|all_lung(29;2.04e-13)|Lung SC(185;0.0367)		all cancers(112;0.000171)|Epithelial(112;0.000398)|OV - Ovarian serous cystadenocarcinoma(117;0.00641)|Lung(94;0.189)		TCTGTATCCAGCATTTTAAAA	0.308												
TNFRSF19	55504	broad.mit.edu	37	13	24190051	24190051	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr13:24190051C>T	uc001uov.1	+	4	290	c.226C>T	c.(226-228)CGG>TGG	p.R76W	TNFRSF19_uc001uot.2_Missense_Mutation_p.R76W|TNFRSF19_uc010tcu.1_5'UTR|TNFRSF19_uc001uow.2_Missense_Mutation_p.R76W	NM_018647	NP_061117	Q9NS68	TNR19_HUMAN	tumor necrosis factor receptor superfamily,	76	TNFR-Cys 2.|Extracellular (Potential).				apoptosis|induction of apoptosis|JNK cascade	integral to membrane|mitochondrion	tumor necrosis factor receptor activity			kidney(1)|skin(1)	2		all_cancers(29;3.4e-22)|all_epithelial(30;8.75e-19)|all_lung(29;5.09e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00193)|Epithelial(112;0.0137)|OV - Ovarian serous cystadenocarcinoma(117;0.0465)|GBM - Glioblastoma multiforme(144;0.184)|Lung(94;0.19)		TGTGACGTGCCGGCTGCACAG	0.537												
RXFP2	122042	broad.mit.edu	37	13	32365959	32365959	+	Nonsense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr13:32365959C>T	uc001utt.2	+	15	1233	c.1162C>T	c.(1162-1164)CGA>TGA	p.R388*	RXFP2_uc010aba.2_Nonsense_Mutation_p.R347*	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	388	Extracellular (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		CAAAAACTTTCGATACTGCTC	0.423												
ZC3H13	23091	broad.mit.edu	37	13	46541793	46541793	+	Silent	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr13:46541793G>A	uc010tfw.1	-	14	4173	c.4167C>T	c.(4165-4167)CGC>CGT	p.R1389R	ZC3H13_uc001vaq.2_5'UTR|ZC3H13_uc001vas.1_Silent_p.R1389R	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1389							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TTGCTTCACAGCGTTTCACAG	0.313												
LRCH1	23143	broad.mit.edu	37	13	47224395	47224395	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr13:47224395G>A	uc001vbj.2	+	2	603	c.367G>A	c.(367-369)GAA>AAA	p.E123K	LRCH1_uc010acp.2_Missense_Mutation_p.E123K|LRCH1_uc001vbk.2_Missense_Mutation_p.E123K|LRCH1_uc001vbl.3_Missense_Mutation_p.E123K	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	123	LRR 2.									ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		TGTATCACTGGAAATTCTTAA	0.348												
PCDH17	27253	broad.mit.edu	37	13	58207414	58207414	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr13:58207414C>T	uc001vhq.1	+	1	1626	c.734C>T	c.(733-735)GCG>GTG	p.A245V	PCDH17_uc010aec.1_Missense_Mutation_p.A245V	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	245	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GTCTTCGAGGCGCCATCCTAC	0.602												
PCDH17	27253	broad.mit.edu	37	13	58299127	58299127	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr13:58299127A>C	uc001vhq.1	+	4	4071	c.3179A>C	c.(3178-3180)AAA>ACA	p.K1060T	PCDH17_uc010aec.1_Missense_Mutation_p.K1059T|PCDH17_uc001vhr.1_Missense_Mutation_p.K149T	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	1060	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TGTGAAGCAAAACCAGGAGCC	0.552												
PCDH20	64881	broad.mit.edu	37	13	61985660	61985660	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr13:61985660T>C	uc001vid.3	-	2	2936	c.2572A>G	c.(2572-2574)AGA>GGA	p.R858G	PCDH20_uc010thj.1_Missense_Mutation_p.R858G	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	831	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GGTTCTTTTCTTAAAAGACTC	0.408												
GPC5	2262	broad.mit.edu	37	13	92408651	92408651	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr13:92408651G>T	uc010tif.1	+	5	1623	c.1257G>T	c.(1255-1257)TGG>TGT	p.W419C		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	419						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TTCCCTGCTGGAATGGAGAAG	0.383												
OR10G2	26534	broad.mit.edu	37	14	22102698	22102698	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr14:22102698C>T	uc010tmc.1	-	1	301	c.301G>A	c.(301-303)GGC>AGC	p.G101S		NM_001005466	NP_001005466	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G,	101	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		GCCACACAGCCACCAAACGGG	0.507												
FOXG1	2290	broad.mit.edu	37	14	29237297	29237297	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr14:29237297G>A	uc001wqe.2	+	1	1011	c.812G>A	c.(811-813)GGC>GAC	p.G271D		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	271	Fork-head.				axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		GGCACCACGGGCAAGCTGCGG	0.701												
SYT16	83851	broad.mit.edu	37	14	62463155	62463155	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr14:62463155A>G	uc001xfu.1	+	1	615	c.418A>G	c.(418-420)ATT>GTT	p.I140V	SYT16_uc010tsd.1_Missense_Mutation_p.I140V	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	140										central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GCTTTCTTCTATTGCGGAGGA	0.473												
NIPA2	81614	broad.mit.edu	37	15	23021278	23021278	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr15:23021278G>A	uc001yux.2	-	4	672	c.59C>T	c.(58-60)TCC>TTC	p.S20F	NIPA2_uc001yuy.2_Missense_Mutation_p.S20F|NIPA2_uc001yuz.2_Missense_Mutation_p.S20F|NIPA2_uc001yva.2_Missense_Mutation_p.S20F|NIPA2_uc001yvb.2_Missense_Mutation_p.S20F|NIPA2_uc010ayb.2_Missense_Mutation_p.S20F	NM_030922	NP_112184	Q8N8Q9	NIPA2_HUMAN	non imprinted in Prader-Willi/Angelman syndrome	20	Helical; (Potential).					early endosome|integral to membrane|plasma membrane				haematopoietic_and_lymphoid_tissue(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;1.48e-06)|Epithelial(43;1.44e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000353)		GAAAATGCTGGAGCTCATAGC	0.428												
SNRPN	6638	broad.mit.edu	37	15	25222082	25222082	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr15:25222082C>A	uc001ywp.1	+	10	1216	c.326C>A	c.(325-327)GCA>GAA	p.A109E	SNRPN_uc001ywq.1_Missense_Mutation_p.A109E|SNRPN_uc001ywr.1_Missense_Mutation_p.A109E|SNRPN_uc001yws.1_Missense_Mutation_p.A109E|SNRPN_uc001ywt.1_Missense_Mutation_p.A109E|SNRPN_uc001ywv.1_Missense_Mutation_p.A112E|SNRPN_uc001yww.1_Missense_Mutation_p.A109E|SNRPN_uc001ywx.1_Missense_Mutation_p.A109E|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_Intron|SNRPN_uc001ywy.1_3'UTR	NM_022807	NP_073718	P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	109					RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			ovary(1)	1		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		GTTGGTAGGGCAGCTGGTAGA	0.562									Prader-Willi_syndrome			
GABRG3	2567	broad.mit.edu	37	15	27271960	27271960	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr15:27271960A>G	uc001zbg.1	+	3	428	c.262A>G	c.(262-264)ATA>GTA	p.I88V	GABRG3_uc001zbf.2_Missense_Mutation_p.I88V	NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	88	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		TGTGTCATCAATAAACATGGT	0.378												
TTBK2	146057	broad.mit.edu	37	15	43067607	43067607	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr15:43067607G>C	uc001zqo.2	-	13	2163	c.1724C>G	c.(1723-1725)ACT>AGT	p.T575S	TTBK2_uc010bcy.2_Missense_Mutation_p.T506S	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	575					cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		AGGACTTCCAGTTGTTTTATG	0.443												
MFAP1	4236	broad.mit.edu	37	15	44105482	44105482	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr15:44105482G>A	uc001zth.1	-	5	875	c.691C>T	c.(691-693)CGC>TGC	p.R231C		NM_005926	NP_005917	P55081	MFAP1_HUMAN	microfibrillar-associated protein 1	231						microfibril				skin(1)	1		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.33e-07)		TCAGCCATGCGTTTTGCTTCC	0.483												
ANPEP	290	broad.mit.edu	37	15	90349397	90349397	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr15:90349397G>A	uc002bop.3	-	2	710	c.418C>T	c.(418-420)CGT>TGT	p.R140C		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	140	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	CCCACACCACGCAGGACCACC	0.617												
SLCO3A1	28232	broad.mit.edu	37	15	92706046	92706046	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr15:92706046G>A	uc002bqx.2	+	10	2015	c.1814G>A	c.(1813-1815)AGC>AAC	p.S605N	SLCO3A1_uc002bqy.2_Missense_Mutation_p.S605N|SLCO3A1_uc002bqz.1_Missense_Mutation_p.S547N	NM_013272	NP_037404	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family,	605	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			skin(1)	1	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			CTGTTCTGGAGCACGTTCTGT	0.562												
LASS3	204219	broad.mit.edu	37	15	100942975	100942975	+	Silent	SNP	T	T	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr15:100942975T>C	uc002bvz.2	-	13	1597	c.1095A>G	c.(1093-1095)TTA>TTG	p.L365L	LASS3_uc002bwa.2_Silent_p.L376L|LASS3_uc002bwb.2_Silent_p.L365L	NM_178842	NP_849164	Q8IU89	CERS3_HUMAN	LAG1 longevity assurance homolog 3	365						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4	Lung NSC(78;0.0018)|all_lung(78;0.00278)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000867)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)			GGCCGTTCTTTAAACAATCCA	0.433												
SEC14L5	9717	broad.mit.edu	37	16	5064923	5064923	+	Silent	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr16:5064923G>A	uc002cye.2	+	16	2223	c.2043G>A	c.(2041-2043)TCG>TCA	p.S681S		NM_014692	NP_055507	O43304	S14L5_HUMAN	SEC14-like 5	681	Ser-rich.					integral to membrane|intracellular	transporter activity				0						CCGCCACCTCGTCCTCCTCCT	0.657												
A2BP1	54715	broad.mit.edu	37	16	7568266	7568266	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr16:7568266G>A	uc002cys.2	+	5	1133	c.145G>A	c.(145-147)GCG>ACG	p.A49T	A2BP1_uc010buf.1_Missense_Mutation_p.A49T|A2BP1_uc002cyr.1_Missense_Mutation_p.A49T|A2BP1_uc002cyt.2_Missense_Mutation_p.A49T|A2BP1_uc010uxz.1_Missense_Mutation_p.A92T|A2BP1_uc010uya.1_Missense_Mutation_p.A85T|A2BP1_uc002cyv.1_Missense_Mutation_p.A49T|A2BP1_uc010uyb.1_Missense_Mutation_p.A49T|A2BP1_uc002cyw.2_Missense_Mutation_p.A69T|A2BP1_uc002cyy.2_Missense_Mutation_p.A69T|A2BP1_uc002cyx.2_Missense_Mutation_p.A69T|A2BP1_uc010uyc.1_Missense_Mutation_p.A69T	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	49					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		TCCCCACCCCGCGCCAGAGTA	0.662												
PMM2	5373	broad.mit.edu	37	16	8941586	8941586	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr16:8941586C>T	uc002czf.3	+	8	715	c.645C>T	c.(643-645)GGC>GGT	p.G215G	PMM2_uc010uyf.1_RNA|PMM2_uc010uyg.1_Silent_p.G132G|PMM2_uc010uyh.1_Silent_p.G90G|PMM2_uc010buj.2_RNA|PMM2_uc010uyi.1_Silent_p.G68G|PMM2_uc002czg.1_5'Flank	NM_000303	NP_000294	O15305	PMM2_HUMAN	phosphomannomutase 2	215					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	phosphomannomutase activity			ovary(1)	1						TCCAGGGTGGCAATGACCATG	0.547												
TEPP	374739	broad.mit.edu	37	16	58019442	58019442	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr16:58019442C>A	uc002emw.3	+	6	781	c.744C>A	c.(742-744)TTC>TTA	p.F248L	TEPP_uc002emv.3_Missense_Mutation_p.F275L	NM_199456	NP_955535	Q6URK8	TEPP_HUMAN	testis/prostate/placenta-expressed protein	248						extracellular region				kidney(1)|central_nervous_system(1)|skin(1)	3						CCCTGCCTTTCGACTCCCTGT	0.627												
CENPN	55839	broad.mit.edu	37	16	81061840	81061840	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr16:81061840G>A	uc002ffx.2	+	10	1665	c.875G>A	c.(874-876)CGA>CAA	p.R292Q	CENPN_uc010vnl.1_Missense_Mutation_p.R258Q|CENPN_uc010vnm.1_Missense_Mutation_p.R272Q|CENPN_uc002ffy.3_Missense_Mutation_p.R292Q	NM_001100624	NP_001094094	Q96H22	CENPN_HUMAN	centromere protein N isoform 2	292					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0						GAACCCCTCCGATGCCTAATA	0.393												
KLHL36	79786	broad.mit.edu	37	16	84690914	84690914	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr16:84690914C>T	uc002fig.2	+	3	642	c.501C>T	c.(499-501)ATC>ATT	p.I167I	KLHL36_uc010chl.2_Silent_p.I166I	NM_024731	NP_079007	Q8N4N3	KLH36_HUMAN	kelch-like 36	167	BACK.									skin(2)	2						ATGCCTTCATCGATGGCTTCA	0.572												
TUBB3	10381	broad.mit.edu	37	16	90002028	90002028	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr16:90002028G>A	uc002fph.1	+	4	1234	c.1169G>A	c.(1168-1170)CGG>CAG	p.R390Q	TUBB3_uc002fpf.2_Missense_Mutation_p.R737Q|TUBB3_uc010ciz.1_Missense_Mutation_p.R318Q|TUBB3_uc002fpg.1_Missense_Mutation_p.R244Q|TUBB3_uc002fpi.1_Missense_Mutation_p.R318Q|TUBB3_uc002fpj.1_Missense_Mutation_p.R318Q|TUBB3_uc010cjb.1_Missense_Mutation_p.R244Q|TUBB3_uc002fpk.1_Missense_Mutation_p.R244Q	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	390					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GCCATGTTCCGGCGCAAGGCC	0.627												
SERPINF2	5345	broad.mit.edu	37	17	1657612	1657612	+	Silent	SNP	C	C	T	rs147941157		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr17:1657612C>T	uc002ftk.1	+	10	1337	c.1260C>T	c.(1258-1260)TTC>TTT	p.F420F	SERPINF2_uc010vqr.1_Silent_p.F356F	NM_000934	NP_000925	P08697	A2AP_HUMAN	alpha-2-antiplasmin isoform a precursor	420					acute-phase response|fibrinolysis|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)	Streptokinase(DB00086)	TCTTCATCTTCGAGGACACCA	0.652												
POLR2A	5430	broad.mit.edu	37	17	7416898	7416898	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr17:7416898C>T	uc002ghf.3	+	29	5549	c.5315C>T	c.(5314-5316)ACT>ATT	p.T1772I		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	1772	26.|52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN].				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				TATTCACCTACTAGTCCCAAC	0.463												
GAS7	8522	broad.mit.edu	37	17	9820567	9820567	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr17:9820567C>A	uc002gmg.1	-	14	1570	c.1409G>T	c.(1408-1410)CGC>CTC	p.R470L	GAS7_uc010vvc.1_Missense_Mutation_p.R284L|GAS7_uc002gmh.1_Missense_Mutation_p.R330L|GAS7_uc010vvd.1_Missense_Mutation_p.R422L|GAS7_uc002gmi.2_Missense_Mutation_p.R406L|GAS7_uc002gmj.1_Missense_Mutation_p.R410L|GAS7_uc010coh.1_Missense_Mutation_p.R410L	NM_201433	NP_958839	O60861	GAS7_HUMAN	growth arrest-specific 7 isoform c	470					cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			lung(1)|pancreas(1)	2						GTCCACAGGGCGGATGTTGCC	0.637			T	MLL	AML*							
MYO1D	4642	broad.mit.edu	37	17	30986210	30986210	+	Silent	SNP	G	G	A	rs150683059		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr17:30986210G>A	uc002hho.1	-	17	2280	c.2268C>T	c.(2266-2268)TAC>TAT	p.Y756Y	MYO1D_uc002hhp.1_Silent_p.Y756Y	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	756						myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			CGTGCTTCCCGTAGTCTCGCA	0.532											OREG0024311	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
AMAC1	146861	broad.mit.edu	37	17	33521011	33521011	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr17:33521011A>C	uc002hjd.2	-	1	402	c.316T>G	c.(316-318)TTC>GTC	p.F106V		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	106	DUF6 1.|Helical; (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		AGGGCACAGAAGAAGGCCCGG	0.587												
KRT39	390792	broad.mit.edu	37	17	39114929	39114929	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr17:39114929T>C	uc002hvo.1	-	7	1436	c.1400A>G	c.(1399-1401)GAG>GGG	p.E467G	KRT39_uc010wfm.1_Missense_Mutation_p.E200G	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	467	Tail.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				ATCCTTAATCTCCTTGGTGAT	0.498												
KRT35	3886	broad.mit.edu	37	17	39635168	39635168	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr17:39635168C>T	uc002hws.2	-	4	834	c.791G>A	c.(790-792)CGA>CAA	p.R264Q		NM_002280	NP_002271	Q92764	KRT35_HUMAN	keratin 35	264	Rod.|Coil 2.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			ovary(1)|skin(1)	2		Breast(137;0.000286)				CTCCAGAACTCGGTTCAGGTC	0.552												
STAT3	6774	broad.mit.edu	37	17	40476996	40476996	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr17:40476996C>T	uc002hzl.1	-	16	1689	c.1449G>A	c.(1447-1449)CTG>CTA	p.L483L	STAT3_uc002hzk.1_Silent_p.L483L|STAT3_uc002hzm.1_Silent_p.L483L|STAT3_uc010wgh.1_Silent_p.L385L|STAT3_uc002hzn.1_Silent_p.L483L	NM_139276	NP_644805	P40763	STAT3_HUMAN	signal transducer and activator of transcription	483					cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		GATTGTTGGTCAGCATGTTGT	0.547									Hyperimmunoglobulin_E_Recurrent_Infection_Syndrome			
SLC35B1	10237	broad.mit.edu	37	17	47782507	47782507	+	Silent	SNP	G	G	A	rs150721486	byFrequency	TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr17:47782507G>A	uc002iph.1	-	5	594	c.507C>T	c.(505-507)GTC>GTT	p.V169V	SLC35B1_uc002ipi.1_Silent_p.V102V|SLC35B1_uc002ipj.1_Silent_p.V45V|SLC35B1_uc010wly.1_Silent_p.V169V	NM_005827	NP_005818	P78383	S35B1_HUMAN	solute carrier family 35, member B1	169	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	UDP-galactose transmembrane transporter activity				0						CTCCATAGCCGACTGTGTGTT	0.488												
ABCA8	10351	broad.mit.edu	37	17	66902186	66902186	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr17:66902186C>T	uc002jhp.2	-	17	2456	c.2277G>A	c.(2275-2277)TCG>TCA	p.S759S	ABCA8_uc002jhq.2_Silent_p.S799S|ABCA8_uc010wqq.1_Silent_p.S799S|ABCA8_uc010wqr.1_Silent_p.S738S|ABCA8_uc002jhr.2_Silent_p.S799S	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	759						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					TTTATTTACCCGATTCATTAA	0.328												
FADS6	283985	broad.mit.edu	37	17	72889611	72889611	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr17:72889611C>T	uc002jmd.1	-	1	95	c.83G>A	c.(82-84)CGG>CAG	p.R28Q		NM_178128	NP_835229	Q8N9I5	FADS6_HUMAN	fatty acid desaturase domain family, member 6	34					fatty acid biosynthetic process	integral to membrane	oxidoreductase activity				0	all_lung(278;0.172)|Lung NSC(278;0.207)					CTCCAGCTCCCGCAGCAGCGC	0.706												
TNRC6C	57690	broad.mit.edu	37	17	76089149	76089149	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr17:76089149G>A	uc002jud.2	+	16	4706	c.4106G>A	c.(4105-4107)CGT>CAT	p.R1369H	TNRC6C_uc002juf.2_Missense_Mutation_p.R1366H	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	1369					gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			AGCTGGTCACGTGCCAAATCT	0.502												
BAHCC1	57597	broad.mit.edu	37	17	79410252	79410252	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr17:79410252C>T	uc002kaf.2	+	3	1877	c.1877C>T	c.(1876-1878)CCG>CTG	p.P626L	BAHCC1_uc002kae.2_5'Flank	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	626							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			CTGCCTGCGCCGCCGGACGAG	0.662												
LAMA1	284217	broad.mit.edu	37	18	7036008	7036008	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr18:7036008G>A	uc002knm.2	-	13	1911	c.1817C>T	c.(1816-1818)TCG>TTG	p.S606L	LAMA1_uc010wzj.1_Missense_Mutation_p.S82L	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	606	Laminin IV type A 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCAGCATGCGACATGAGGTT	0.433												
CDH2	1000	broad.mit.edu	37	18	25727656	25727656	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr18:25727656T>G	uc002kwg.2	-	2	612	c.153A>C	c.(151-153)GAA>GAC	p.E51D		NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	51					adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						GAGGCTGTCCTTCATGCACAT	0.398												
SMAD2	4087	broad.mit.edu	37	18	45395639	45395639	+	Nonsense_Mutation	SNP	G	G	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr18:45395639G>C	uc002lcy.2	-	4	743	c.495C>G	c.(493-495)TAC>TAG	p.Y165*	SMAD2_uc002lcz.2_Nonsense_Mutation_p.Y165*|SMAD2_uc010xdc.1_Nonsense_Mutation_p.Y135*|SMAD2_uc010xdd.1_Nonsense_Mutation_p.Y135*	NM_005901	NP_005892	Q15796	SMAD2_HUMAN	Sma- and Mad-related protein 2 isoform 1	165	MH1.				anterior/posterior pattern formation|cell fate commitment|common-partner SMAD protein phosphorylation|intracellular signal transduction|mesoderm formation|negative regulation of transcription, DNA-dependent|palate development|paraxial mesoderm morphogenesis|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|regulation of binding|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	activin responsive factor complex|cytosol	activating transcription factor binding|co-SMAD binding|double-stranded DNA binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			large_intestine(3)|lung(1)|central_nervous_system(1)	5						TCTGATAGTGGTAAGGGTTTA	0.368												
ZNF516	9658	broad.mit.edu	37	18	74154275	74154275	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr18:74154275C>T	uc010dqx.1	-	2	971	c.736G>A	c.(736-738)GGG>AGG	p.G246R	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GGGAACTCCCCGGGGCTCAGC	0.687												
ZNF236	7776	broad.mit.edu	37	18	74622027	74622027	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr18:74622027G>T	uc002lmi.2	+	15	2747	c.2549G>T	c.(2548-2550)GGG>GTG	p.G850V	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	850					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		TCCTCAGATGGGTTTGTGGCT	0.498												
EMR1	2015	broad.mit.edu	37	19	6897451	6897451	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr19:6897451G>A	uc002mfw.2	+	5	445	c.407G>A	c.(406-408)TGC>TAC	p.C136Y	EMR1_uc010dvc.2_Missense_Mutation_p.C136Y|EMR1_uc010dvb.2_Missense_Mutation_p.C84Y|EMR1_uc010xji.1_Intron|EMR1_uc010xjj.1_Missense_Mutation_p.C136Y	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	136	Extracellular (Potential).|EGF-like 3; calcium-binding (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					ATCAATGAGTGCCTCACCAGC	0.478												
MAN2B1	4125	broad.mit.edu	37	19	12760024	12760024	+	Missense_Mutation	SNP	T	T	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr19:12760024T>A	uc002mub.2	-	20	2438	c.2362A>T	c.(2362-2364)AAC>TAC	p.N788Y	MAN2B1_uc010dyv.1_Missense_Mutation_p.N787Y	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	788					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						AGCTGCATGTTTCCATCCTGG	0.582												
RAD23A	5886	broad.mit.edu	37	19	13059627	13059627	+	Silent	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr19:13059627G>A	uc002mvw.1	+	5	709	c.600G>A	c.(598-600)ACG>ACA	p.T200T	RAD23A_uc002mvx.1_Silent_p.T200T|RAD23A_uc002mvz.1_Silent_p.T200T|RAD23A_uc002mwa.1_Silent_p.T200T|RAD23A_uc002mvy.1_Silent_p.T35T|RAD23A_uc010xmw.1_Silent_p.T35T	NM_005053	NP_005044	P54725	RD23A_HUMAN	UV excision repair protein RAD23 homolog A	200	UBA 1.				interspecies interaction between organisms|nucleotide-excision repair|positive regulation of viral genome replication|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			central_nervous_system(1)	1						ATCTGCTCACGGTGAGGTGGG	0.647								NER				
OR10H2	26538	broad.mit.edu	37	19	15839276	15839276	+	Silent	SNP	C	C	T	rs147373947	byFrequency	TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr19:15839276C>T	uc002nbm.2	+	1	443	c.423C>T	c.(421-423)TGC>TGT	p.C141C		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	141	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					CACGGGGCTGCGCCTGCCTGG	0.632												
ZNF253	56242	broad.mit.edu	37	19	20003046	20003046	+	Silent	SNP	T	T	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr19:20003046T>C	uc002noj.2	+	4	1082	c.990T>C	c.(988-990)CAT>CAC	p.H330H	ZNF253_uc002nok.2_Silent_p.H254H|ZNF253_uc002nol.2_RNA	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	330	C2H2-type 6.			Missing (in Ref. 1; AAC26844).	negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTACTATACATAAGAGAATTC	0.388												
ZNF431	170959	broad.mit.edu	37	19	21365865	21365865	+	Silent	SNP	T	T	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr19:21365865T>A	uc002npp.2	+	5	906	c.759T>A	c.(757-759)ATT>ATA	p.I253I	ZNF431_uc010ecq.2_Silent_p.I162I|ZNF431_uc010ecr.2_Silent_p.I254I	NM_133473	NP_597730	Q8TF32	ZN431_HUMAN	zinc finger protein 431	253	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2						ACAAGAGAATTCATACTGGAG	0.363												
ZNF99	7652	broad.mit.edu	37	19	22940707	22940707	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr19:22940707T>G	uc010xrh.1	-	5	1731	c.1731A>C	c.(1729-1731)AAA>AAC	p.K577N		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TATGAATTACTTTATGTCTAG	0.363												
TSHZ3	57616	broad.mit.edu	37	19	31768677	31768677	+	Silent	SNP	C	C	T	rs151270303		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr19:31768677C>T	uc002nsy.3	-	2	2087	c.2022G>A	c.(2020-2022)CCG>CCA	p.P674P		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	674					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					ACCCATCCCGCGGGGGGCTGG	0.657												
ACTN4	81	broad.mit.edu	37	19	39215080	39215080	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr19:39215080C>T	uc002oja.1	+	16	1944	c.1885C>T	c.(1885-1887)CTG>TTG	p.L629L	ACTN4_uc002ojb.1_5'Flank	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	629	Spectrin 3.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GGTGCAGCAGCTGGTGCCAAA	0.701												
RTN2	6253	broad.mit.edu	37	19	45998025	45998025	+	Silent	SNP	G	G	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr19:45998025G>T	uc002pcb.2	-	3	546	c.318C>A	c.(316-318)GGC>GGA	p.G106G	RTN2_uc002pcc.2_Silent_p.G106G|RTN2_uc002pcd.2_RNA	NM_005619	NP_005610	O75298	RTN2_HUMAN	reticulon 2 isoform A	106						integral to endoplasmic reticulum membrane	signal transducer activity			ovary(3)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)		CCAAGCTGTCGCCCAGGCTGG	0.711												
ZC3H4	23211	broad.mit.edu	37	19	47588354	47588354	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr19:47588354C>T	uc002pga.3	-	8	1104	c.1066G>A	c.(1066-1068)GGA>AGA	p.G356R	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	356	Gly-rich.						nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		TCGTTCATTCCGCCCTTGTTC	0.587												
KLK13	26085	broad.mit.edu	37	19	51559890	51559890	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr19:51559890C>T	uc002pvn.2	-	5	831	c.788G>A	c.(787-789)CGA>CAA	p.R263Q	KLK13_uc002pvl.2_RNA|KLK13_uc002pvm.2_RNA|KLK13_uc002pvo.2_RNA|KLK13_uc002pvp.2_RNA|KLK13_uc010eon.2_Missense_Mutation_p.R190Q|KLK13_uc002pvq.2_RNA|KLK13_uc010eoo.2_Missense_Mutation_p.R111Q	NM_015596	NP_056411	Q9UKR3	KLK13_HUMAN	kallikrein 13 precursor	263	Peptidase S1.				proteolysis		protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00432)		TTCATATTTTCGGATTGTTTC	0.512												
ZNF347	84671	broad.mit.edu	37	19	53645344	53645344	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr19:53645344A>G	uc002qbb.1	-	5	806	c.737T>C	c.(736-738)TTA>TCA	p.L246S	ZNF347_uc010eql.1_Missense_Mutation_p.L247S|ZNF347_uc002qbc.1_Missense_Mutation_p.L247S	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		TGTGAGTAATAAAGAAGAGAT	0.358												
LENG9	94059	broad.mit.edu	37	19	54974143	54974143	+	Missense_Mutation	SNP	C	C	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr19:54974143C>G	uc010yez.1	-	1	752	c.633G>C	c.(631-633)AAG>AAC	p.K211N		NM_198988	NP_945339	Q96B70	LENG9_HUMAN	leukocyte receptor cluster (LRC) member 9	211					RNA metabolic process	intracellular	catalytic activity|nucleic acid binding|zinc ion binding				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.134)		TGCTCCCTCGCTTGGGGGCAG	0.716												
NLRP11	204801	broad.mit.edu	37	19	56307512	56307512	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr19:56307512C>T	uc010ygf.1	-	8	2987	c.2276G>A	c.(2275-2277)AGG>AAG	p.R759K	NLRP11_uc002qlz.2_Missense_Mutation_p.R606K|NLRP11_uc002qmb.2_Missense_Mutation_p.R660K|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	759	LRR 3.						ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CCCGTCGCTCCTCAGCGGATT	0.493												
ZNF583	147949	broad.mit.edu	37	19	56935080	56935080	+	Silent	SNP	T	T	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr19:56935080T>C	uc010ygl.1	+	5	1218	c.1053T>C	c.(1051-1053)CCT>CCC	p.P351P	ZNF583_uc002qnc.2_Silent_p.P351P|ZNF583_uc010ygm.1_Silent_p.P351P	NM_001159860	NP_001153332	Q96ND8	ZN583_HUMAN	zinc finger protein 583	351				P -> R (in Ref. 3; AAB81088).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		GAGAGAAACCTTATGTGTGTA	0.403												
PEG3	5178	broad.mit.edu	37	19	57335747	57335747	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr19:57335747G>T	uc002qnu.2	-	1	628	c.277C>A	c.(277-279)CAG>AAG	p.Q93K	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_5'UTR|ZIM2_uc002qnq.2_5'UTR|ZIM2_uc010etp.2_5'UTR|ZIM2_uc010ygs.1_5'UTR|PEG3_uc002qnt.2_Missense_Mutation_p.Q93K|PEG3_uc002qnv.2_Missense_Mutation_p.Q93K|PEG3_uc002qnw.2_5'UTR|PEG3_uc002qnx.2_5'UTR|PEG3_uc010etr.2_Missense_Mutation_p.Q93K	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	93	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GTCAGGTACTGCTCAAGGACC	0.542												
ZNF134	7693	broad.mit.edu	37	19	58132192	58132192	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr19:58132192C>T	uc002qpn.2	+	3	804	c.705C>T	c.(703-705)AGC>AGT	p.S235S	ZNF134_uc002qpo.2_Silent_p.S62S|ZNF211_uc010yhb.1_5'UTR	NM_003435	NP_003426	P52741	ZN134_HUMAN	zinc finger protein 134	235	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		ATGAATGCAGCGAATGTGGAA	0.443												
PXDN	7837	broad.mit.edu	37	2	1643130	1643130	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr2:1643130C>A	uc002qxa.2	-	20	4081	c.4017G>T	c.(4015-4017)GAG>GAT	p.E1339D		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1339					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GGTAGCTGAACTCAAGAGACC	0.507												
BIRC6	57448	broad.mit.edu	37	2	32707635	32707635	+	Missense_Mutation	SNP	G	G	A	rs144411884		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr2:32707635G>A	uc010ezu.2	+	39	7815	c.7681G>A	c.(7681-7683)GTT>ATT	p.V2561I		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2561					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GACAGTTAGCGTTTCAGTCTC	0.393												
RASGRP3	25780	broad.mit.edu	37	2	33752219	33752220	+	Missense_Mutation	DNP	AC	AC	CA			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr2:33752219_33752220AC>CA	uc002rox.2	+	11	1450_1451	c.823_824AC>CA	c.(823-825)ACA>CAA	p.T275Q	RASGRP3_uc010ync.1_Missense_Mutation_p.T275Q|RASGRP3_uc002roy.2_Missense_Mutation_p.T275Q	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	275	Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					GAATGAAATGACAGAGTTGGTC	0.485												
NRXN1	9378	broad.mit.edu	37	2	50780014	50780014	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr2:50780014G>T	uc010fbq.2	-	9	3067	c.1590C>A	c.(1588-1590)TTC>TTA	p.F530L	NRXN1_uc002rxb.3_Missense_Mutation_p.F162L|NRXN1_uc002rxe.3_Missense_Mutation_p.F490L|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:Variant_position_missing_in_P58400_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GCAAAGAGATGAAAGACTCTG	0.418												
CCDC85A	114800	broad.mit.edu	37	2	56570051	56570051	+	Silent	SNP	A	A	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr2:56570051A>G	uc002rzn.2	+	3	1780	c.1278A>G	c.(1276-1278)AGA>AGG	p.R426R		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	426	Potential.									breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TGGAGGCAAGAGTAAGACAGC	0.418												
EIF2AK3	9451	broad.mit.edu	37	2	88890523	88890523	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr2:88890523A>G	uc002stc.3	-	5	1017	c.815T>C	c.(814-816)ATG>ACG	p.M272T		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	272	Lumenal (Potential).				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						TCTCGTTTCCATGTCTGGAAT	0.368												
MGAT4A	11320	broad.mit.edu	37	2	99260500	99260500	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr2:99260500C>T	uc002sze.2	-	10	1220	c.906G>A	c.(904-906)GCG>GCA	p.A302A	C2orf64_uc002sza.2_RNA|MGAT4A_uc010yvm.1_Silent_p.A174A|MGAT4A_uc010fil.2_Silent_p.A56A	NM_012214	NP_036346	Q9UM21	MGT4A_HUMAN	alpha-1,3-mannosyl-glycoprotein	302	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1						TAAGATCCGGCGCTTGAAACA	0.408												
LRP1B	53353	broad.mit.edu	37	2	140990805	140990805	+	Nonsense_Mutation	SNP	C	C	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr2:140990805C>A	uc002tvj.1	-	91	14722	c.13750G>T	c.(13750-13752)GAA>TAA	p.E4584*		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4584	Cytoplasmic (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGAAGCAGTTCTTTCCTTTCA	0.333										TSP Lung(27;0.18)		
LRP1B	53353	broad.mit.edu	37	2	141215210	141215210	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr2:141215210T>G	uc002tvj.1	-	61	10608	c.9636A>C	c.(9634-9636)CAA>CAC	p.Q3212H		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3212	Extracellular (Potential).|LDL-receptor class B 31.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTGGAATATCTTGATTAGGGA	0.418										TSP Lung(27;0.18)		
LRP1B	53353	broad.mit.edu	37	2	141751631	141751631	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr2:141751631T>G	uc002tvj.1	-	16	3549	c.2577A>C	c.(2575-2577)CAA>CAC	p.Q859H	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	859	Extracellular (Potential).|LDL-receptor class A 3.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCCACCGAGCTTGGATACAGT	0.423										TSP Lung(27;0.18)		
LRP2	4036	broad.mit.edu	37	2	170063434	170063434	+	Nonsense_Mutation	SNP	C	C	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr2:170063434C>A	uc002ues.2	-	39	7009	c.6796G>T	c.(6796-6798)GAG>TAG	p.E2266*		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2266	LDL-receptor class B 23.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCAGAGTTCTCTCCATTGATA	0.403												
TTN	7273	broad.mit.edu	37	2	179439346	179439346	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr2:179439346A>C	uc010zfg.1	-	275	64033	c.63809T>G	c.(63808-63810)GTT>GGT	p.V21270G	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V14965G|TTN_uc010zfi.1_Missense_Mutation_p.V14898G|TTN_uc010zfj.1_Missense_Mutation_p.V14773G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22197							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCCTTGGTAACTGCAGTTAC	0.433												
TTN	7273	broad.mit.edu	37	2	179669304	179669304	+	Silent	SNP	G	G	A	rs143623862		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr2:179669304G>A	uc002und.2	-	2	291	c.66C>T	c.(64-66)ACC>ACT	p.T22T	TTN_uc010zfg.1_Silent_p.T22T|TTN_uc010zfh.1_Silent_p.T22T|TTN_uc010zfi.1_Silent_p.T22T|TTN_uc010zfj.1_Silent_p.T22T|TTN_uc002unb.2_Silent_p.T22T			Q8WZ42	TITIN_HUMAN	Homo sapiens cDNA FLJ32040 fis, clone NTONG2000858, highly similar to H.sapiens mRNA for titin protein.	22							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAAGGTTGCGGTACTACCCT	0.438												
ZNF804A	91752	broad.mit.edu	37	2	185802547	185802547	+	Silent	SNP	T	T	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr2:185802547T>G	uc002uph.2	+	4	3018	c.2424T>G	c.(2422-2424)CCT>CCG	p.P808P		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	808						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CCTGCAAGCCTAAAAAGAAAC	0.383												
SLC11A1	6556	broad.mit.edu	37	2	219258851	219258851	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr2:219258851C>T	uc002vhv.2	+	13	1663	c.1323C>T	c.(1321-1323)TTC>TTT	p.F441F	SLC11A1_uc010zkc.1_Silent_p.F374F|SLC11A1_uc002vhu.1_Silent_p.F236F|SLC11A1_uc002vhw.2_Silent_p.F323F|SLC11A1_uc010fvr.2_Silent_p.F236F	NM_000578	NP_000569	P49279	NRAM1_HUMAN	natural resistance-associated macrophage protein	441	Helical; (Potential).			F -> V (in Ref. 5; CAA57541).	activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			ovary(3)|central_nervous_system(1)	4		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGCTCCCGTTCGCCGTGCTGC	0.537												
DGKD	8527	broad.mit.edu	37	2	234299087	234299087	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr2:234299087C>T	uc002vui.1	+	3	318	c.306C>T	c.(304-306)AGC>AGT	p.S102S	DGKD_uc002vuj.1_Silent_p.S58S	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	102	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	CAGATGCCAGCGTAGCTGAAT	0.423												
HDLBP	3069	broad.mit.edu	37	2	242181952	242181952	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr2:242181952C>T	uc002waz.2	-	17	2320	c.2092G>A	c.(2092-2094)GAC>AAC	p.D698N	HDLBP_uc002wba.2_Missense_Mutation_p.D698N|HDLBP_uc002wbb.2_Missense_Mutation_p.D650N	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	698	KH 8.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		ACAACGGTGTCGCTTCCTGAA	0.602												
D2HGDH	728294	broad.mit.edu	37	2	242695360	242695360	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr2:242695360G>A	uc002wce.1	+	9	1410	c.1237G>A	c.(1237-1239)GAC>AAC	p.D413N	D2HGDH_uc010zpc.1_RNA|D2HGDH_uc010fzq.1_Missense_Mutation_p.D279N|D2HGDH_uc002wcg.1_RNA|D2HGDH_uc002wch.2_RNA|D2HGDH_uc002wci.2_Missense_Mutation_p.D112N	NM_152783	NP_689996	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase precursor	413					2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		GCGGCTCTACGACATCGTGAC	0.567												
VPS16	64601	broad.mit.edu	37	20	2847197	2847197	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr20:2847197A>G	uc002whe.2	+	24	2545	c.2497A>G	c.(2497-2499)AGG>GGG	p.R833G	VPS16_uc002whh.2_Intron|PTPRA_uc002whj.2_Intron|VPS16_uc002whf.2_Missense_Mutation_p.R689G|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_Missense_Mutation_p.R519G|VPS16_uc002whi.2_Missense_Mutation_p.R317G	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	833					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4						TCAACGGGCCAGGGCACAAGC	0.582												
PLCB1	23236	broad.mit.edu	37	20	8665634	8665634	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr20:8665634C>T	uc002wnb.2	+	10	921	c.918C>T	c.(916-918)GTC>GTT	p.V306V	PLCB1_uc010zrb.1_Silent_p.V205V|PLCB1_uc002wna.2_Silent_p.V306V|PLCB1_uc002wnc.1_Silent_p.V205V	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	306					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						AAAACGGAGTCGTTTCACCTG	0.413												
SEMG1	6406	broad.mit.edu	37	20	43837052	43837052	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr20:43837052C>T	uc002xni.2	+	2	1171	c.1114C>T	c.(1114-1116)CGC>TGC	p.R372C	SEMG1_uc002xnj.2_Missense_Mutation_p.R312C|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Intron	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	372	58 AA repeat 2.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				TGTATCCCAACGCAGTATTTA	0.418												
TFAP2C	7022	broad.mit.edu	37	20	55206365	55206365	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr20:55206365C>T	uc002xya.2	+	2	396	c.153C>T	c.(151-153)GTC>GTT	p.V51V	TFAP2C_uc010zzi.1_5'UTR	NM_003222	NP_003213	Q92754	AP2C_HUMAN	transcription factor AP-2 gamma	51	Gln/Pro-rich (transactivation domain).				cell-cell signaling|male gonad development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Colorectal(105;0.229)			ACACTGGAGTCGCCGAATATC	0.687												
RIPK4	54101	broad.mit.edu	37	21	43161417	43161417	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr21:43161417C>T	uc002yzn.1	-	8	1984	c.1936G>A	c.(1936-1938)GAG>AAG	p.E646K		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	646						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						TGCCCCGTCTCCGCGGCCACG	0.692												
LARGE	9215	broad.mit.edu	37	22	34046630	34046630	+	Missense_Mutation	SNP	G	G	A	rs143437080	byFrequency	TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr22:34046630G>A	uc003and.3	-	4	710	c.131C>T	c.(130-132)CCG>CTG	p.P44L	LARGE_uc003ane.3_Missense_Mutation_p.P44L|LARGE_uc010gwp.2_Missense_Mutation_p.P44L|LARGE_uc011ame.1_5'UTR|LARGE_uc011amf.1_Missense_Mutation_p.P44L	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	44	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				GGACTCCAGCGGTGACAGAGA	0.632												
TEF	7008	broad.mit.edu	37	22	41791804	41791804	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr22:41791804G>A	uc003azy.2	+	4	838	c.752G>A	c.(751-753)CGG>CAG	p.R251Q	TEF_uc003azx.2_Missense_Mutation_p.R221Q|TEF_uc011apa.1_Missense_Mutation_p.R256Q	NM_003216	NP_003207	Q10587	TEF_HUMAN	thyrotrophic embryonic factor isoform 1	251	Basic motif.				rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AAACGGTCACGGGATGCCCGG	0.582												
PKDREJ	10343	broad.mit.edu	37	22	46653338	46653338	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr22:46653338G>C	uc003bhh.2	-	1	5882	c.5882C>G	c.(5881-5883)GCT>GGT	p.A1961G		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1961	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TTCTGCTGAAGCTTTTCTGTC	0.388												
CELSR1	9620	broad.mit.edu	37	22	46929691	46929691	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr22:46929691C>T	uc003bhw.1	-	1	3377	c.3377G>A	c.(3376-3378)TGC>TAC	p.C1126Y		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1126	Extracellular (Potential).|Cadherin 9.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GGCCGGGATGCAGCCGATCAC	0.607												
GRM7	2917	broad.mit.edu	37	3	6903385	6903385	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr3:6903385C>T	uc003bqm.2	+	1	584	c.310C>T	c.(310-312)CGG>TGG	p.R104W	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.R104W|GRM7_uc003bql.2_Missense_Mutation_p.R104W	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	104	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	GCTGGGCGCGCGGATCCTGGA	0.597												
HDAC11	79885	broad.mit.edu	37	3	13538326	13538326	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr3:13538326C>T	uc003bxy.2	+	4	476	c.343C>T	c.(343-345)CGG>TGG	p.R115W	HDAC11_uc010heb.2_Missense_Mutation_p.R87W|HDAC11_uc011aux.1_Intron|HDAC11_uc003bxz.2_Missense_Mutation_p.R87W|HDAC11_uc011auy.1_Missense_Mutation_p.R64W	NM_024827	NP_079103	Q96DB2	HDA11_HUMAN	histone deacetylase 11 isoform 1	115	Histone deacetylase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex|plasma membrane	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			ovary(2)	2						GAGGCCCCTTCGGACCCAGAC	0.572											OREG0015411	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
SETD2	29072	broad.mit.edu	37	3	47098880	47098880	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr3:47098880G>A	uc003cqs.2	-	15	6447	c.6394C>T	c.(6394-6396)CGG>TGG	p.R2132W	SETD2_uc003cqv.2_Missense_Mutation_p.R2199W|SETD2_uc003cqt.1_RNA	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2132	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding	p.R1629fs*15(1)		kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TGAGCCTCCCGTTGAGCCACC	0.453			N|F|S|Mis		clear cell renal carcinoma							
STAB1	23166	broad.mit.edu	37	3	52556844	52556844	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr3:52556844C>A	uc003dej.2	+	62	6872	c.6798C>A	c.(6796-6798)CAC>CAA	p.H2266Q	STAB1_uc003dek.1_Missense_Mutation_p.H281Q|STAB1_uc003del.2_Missense_Mutation_p.H153Q	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	2266	Extracellular (Potential).|Link.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CCACTGCCCACCCTGTGGTTT	0.612												
ROBO2	6092	broad.mit.edu	37	3	77684060	77684060	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr3:77684060G>T	uc003dpy.3	+	24	4443	c.3800G>T	c.(3799-3801)AGC>ATC	p.S1267I	ROBO2_uc003dpz.2_Missense_Mutation_p.S1332I|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.S1271I	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	1267	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CGACCTACCAGCCCATTTTCT	0.468												
ARL13B	200894	broad.mit.edu	37	3	93758768	93758768	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr3:93758768G>A	uc003drc.2	+	6	1020	c.734G>A	c.(733-735)GGT>GAT	p.G245D	ARL13B_uc010hop.2_Missense_Mutation_p.G96D|ARL13B_uc003drd.2_Missense_Mutation_p.G138D|ARL13B_uc003dre.2_Missense_Mutation_p.G230D|ARL13B_uc003drf.2_Missense_Mutation_p.G245D|ARL13B_uc003drg.2_Missense_Mutation_p.G142D	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1	245	Potential.						GTP binding				0						GGAACCAGTGGTCTGGCTGAG	0.388												
COPB2	9276	broad.mit.edu	37	3	139078162	139078162	+	Silent	SNP	C	C	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr3:139078162C>A	uc003etf.3	-	18	2383	c.2253G>T	c.(2251-2253)CTG>CTT	p.L751L	COPB2_uc011bmv.1_Silent_p.L722L|COPB2_uc010hui.2_Silent_p.L722L	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	751	WD 9.				COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						CAGCTTCTGGCAGCCGTCCAG	0.403												
CLSTN2	64084	broad.mit.edu	37	3	140282887	140282887	+	Missense_Mutation	SNP	G	G	A	rs140778211		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr3:140282887G>A	uc003etn.2	+	16	2757	c.2567G>A	c.(2566-2568)CGG>CAG	p.R856Q		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	856	Cytoplasmic (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						TACCGGGTCCGGATCGCCCAC	0.547										HNSCC(16;0.037)		
CCNL1	57018	broad.mit.edu	37	3	156866355	156866355	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr3:156866355G>T	uc003fbf.2	-	11	1855	c.1256C>A	c.(1255-1257)TCT>TAT	p.S419Y	CCNL1_uc003fbd.1_Intron|CCNL1_uc003fbe.2_Missense_Mutation_p.S213Y|CCNL1_uc003fbg.2_RNA|CCNL1_uc011bor.1_RNA	NM_020307	NP_064703	Q9UK58	CCNL1_HUMAN	cyclin L1	419	RS.				regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			lung(3)|breast(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(72;0.0295)|Lung(72;0.0308)			GTATGTTCCAGATCGACTCCG	0.428												
SI	6476	broad.mit.edu	37	3	164785157	164785157	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr3:164785157T>G	uc003fei.2	-	6	668	c.606A>C	c.(604-606)CAA>CAC	p.Q202H		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	202	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCCTAATAACTTGGATGCTAA	0.308										HNSCC(35;0.089)		
PIGG	54872	broad.mit.edu	37	4	515701	515701	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr4:515701G>A	uc003gak.3	+	8	1721	c.1585G>A	c.(1585-1587)GTG>ATG	p.V529M	PIGG_uc003gaj.3_Missense_Mutation_p.V521M|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Missense_Mutation_p.V396M|PIGG_uc003gal.3_Missense_Mutation_p.V440M|PIGG_uc003gai.2_Intron|PIGG_uc011buw.1_3'UTR|PIGG_uc003gam.2_3'UTR|PIGG_uc003gan.2_Missense_Mutation_p.V440M	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	529					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						TCTGACCAACGTGCTCGTGGG	0.572												
DCAF4L1	285429	broad.mit.edu	37	4	41984183	41984183	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr4:41984183G>A	uc003gwk.2	+	1	471	c.374G>A	c.(373-375)CGG>CAG	p.R125Q		NM_001029955	NP_001025126	Q3SXM0	DC4L1_HUMAN	WD repeat domain 21B	125										skin(1)	1						GTCCCCAACCGGAAGGTGAAG	0.562												
UNC5C	8633	broad.mit.edu	37	4	96256683	96256683	+	Missense_Mutation	SNP	T	T	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr4:96256683T>A	uc003htp.1	-	2	378	c.224A>T	c.(223-225)AAG>ATG	p.K75M	UNC5C_uc010ilc.1_Missense_Mutation_p.K75M|UNC5C_uc003htq.2_Missense_Mutation_p.K75M	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	75	Extracellular (Potential).|Ig-like.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GGGCTTATTCTTCACAATATA	0.423												
TACR3	6870	broad.mit.edu	37	4	104511023	104511023	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr4:104511023C>A	uc003hxe.1	-	5	1357	c.1214G>T	c.(1213-1215)AGA>ATA	p.R405I		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	405	Cytoplasmic (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GGACTCCATTCTGGTCACGGT	0.507												
GYPA	2993	broad.mit.edu	37	4	144918764	144918764	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr4:144918764T>G	uc003ijn.2	-	5	411	c.295A>C	c.(295-297)ATT>CTT	p.I99L	GYPB_uc011chs.1_Intron|GYPB_uc011cht.1_RNA|GYPB_uc011chu.1_RNA|GYPB_uc010ioo.1_Intron|GYPB_uc010iop.2_RNA|GYPB_uc011chv.1_RNA|GYPB_uc011chw.1_Intron|GYPB_uc011chx.1_RNA|GYPB_uc003ijm.1_Missense_Mutation_p.I67L|GYPB_uc011chy.1_RNA|GYPB_uc011chz.1_Intron			P02724	GLPA_HUMAN	SubName: Full=Glycophorin MiX; Flags: Fragment;	96	Helical.				interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)	2	all_hematologic(180;0.15)					ACACACAAAATAATGAGTATT	0.328												
KLKB1	3818	broad.mit.edu	37	4	187158094	187158094	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr4:187158094G>A	uc003iyy.2	+	5	559	c.488G>A	c.(487-489)CGG>CAG	p.R163Q	KLKB1_uc011clc.1_5'UTR|KLKB1_uc011cld.1_Missense_Mutation_p.R125Q	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	163	Apple 2.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		GCAGAGTACCGGTGAGTACAA	0.413												
TTC23L	153657	broad.mit.edu	37	5	34850318	34850318	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr5:34850318G>T	uc003jiu.2	+	4	387	c.284G>T	c.(283-285)CGA>CTA	p.R95L		NM_144725	NP_653326	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	95	Potential.						binding			central_nervous_system(1)	1						GAGCTGATTCGATGTGTCATC	0.438												
MRPS30	10884	broad.mit.edu	37	5	44809103	44809103	+	Silent	SNP	T	T	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr5:44809103T>G	uc003joh.2	+	1	77	c.39T>G	c.(37-39)GGT>GGG	p.G13G	MRPS30_uc003joi.1_5'Flank	NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	13					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					TGCTACGCGGTCCGAGGCTTT	0.637												
HCN1	348980	broad.mit.edu	37	5	45262804	45262804	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr5:45262804T>G	uc003jok.2	-	8	1917	c.1892A>C	c.(1891-1893)GAG>GCG	p.E631A		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	631	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						CTGCACCATCTCCCTGTCATG	0.453												
HCN1	348980	broad.mit.edu	37	5	45645310	45645310	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr5:45645310T>C	uc003jok.2	-	2	851	c.826A>G	c.(826-828)AGA>GGA	p.R276G		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	276	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TGTATGTATCTAATTAACCTT	0.333												
ADAMTS19	171019	broad.mit.edu	37	5	128984623	128984623	+	Silent	SNP	C	C	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr5:128984623C>A	uc003kvb.1	+	13	2118	c.2118C>A	c.(2116-2118)TCC>TCA	p.S706S	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	706	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		GAACTTCCTCCCCAAAGCATA	0.438												
PCDHA9	9752	broad.mit.edu	37	5	140229433	140229433	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr5:140229433C>T	uc003lhu.2	+	1	2077	c.1353C>T	c.(1351-1353)AAC>AAT	p.N451N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.N451N	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	451	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAACGACAACGCACCAGCGT	0.672												
PCDHA13	56136	broad.mit.edu	37	5	140261977	140261977	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr5:140261977G>A	uc003lif.2	+	1	124	c.124G>A	c.(124-126)GGC>AGC	p.G42S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.G42S|PCDHA13_uc003lid.2_Missense_Mutation_p.G42S	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	42	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCAAAACACGGCACCTTCGT	0.657												
PCDHB4	56131	broad.mit.edu	37	5	140503532	140503532	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr5:140503532G>A	uc003lip.1	+	1	1952	c.1952G>A	c.(1951-1953)CGC>CAC	p.R651H		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	651	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGCCTCCGCGCTCGGCCACC	0.706												
PCDHGB2	56103	broad.mit.edu	37	5	140741307	140741307	+	Silent	SNP	C	C	T	rs1860252		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr5:140741307C>T	uc003ljs.1	+	1	1605	c.1605C>T	c.(1603-1605)CGC>CGT	p.R535R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Silent_p.R535R|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	535	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAGGCCCGCGACCAGGGCT	0.687												
PCDHGB3	56102	broad.mit.edu	37	5	140752045	140752045	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr5:140752045C>T	uc003ljw.1	+	1	2084	c.2084C>T	c.(2083-2085)GCG>GTG	p.A695V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.A695V|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	695	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTAGTAGTGGCGTTGGCCTTG	0.572												
PCDHGB4	8641	broad.mit.edu	37	5	140768837	140768837	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr5:140768837C>A	uc003lkc.1	+	1	1386	c.1386C>A	c.(1384-1386)AAC>AAA	p.N462K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.N462K	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	462	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCCGAGAACAACCCGCCTG	0.547												
ARAP3	64411	broad.mit.edu	37	5	141052170	141052170	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr5:141052170C>T	uc003llm.2	-	9	1412	c.1334G>A	c.(1333-1335)CGG>CAG	p.R445Q	ARAP3_uc011dbe.1_Missense_Mutation_p.R107Q|ARAP3_uc003lln.2_Missense_Mutation_p.R367Q|ARAP3_uc003llo.1_Missense_Mutation_p.R445Q	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	445	PH 2.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						CTTGGTCTCCCGGACGCTGCA	0.637												
ZNF454	285676	broad.mit.edu	37	5	178391973	178391973	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr5:178391973A>G	uc003mjo.1	+	5	839	c.568A>G	c.(568-570)AGT>GGT	p.S190G	ZNF454_uc010jkz.1_Missense_Mutation_p.S190G	NM_182594	NP_872400	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	190	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		CTTCTCTAAGAGTTCAACTCT	0.338												
ATXN1	6310	broad.mit.edu	37	6	16326864	16326864	+	Missense_Mutation	SNP	C	C	T	rs139918586		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr6:16326864C>T	uc003nbt.2	-	8	2649	c.1678G>A	c.(1678-1680)GTG>ATG	p.V560M	ATXN1_uc010jpi.2_Missense_Mutation_p.V560M|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	560	Self-association.|Interaction with USP7.|RNA-binding.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				GGGGAGGCCACGGACTGCACC	0.632												
NUP153	9972	broad.mit.edu	37	6	17629497	17629497	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr6:17629497T>C	uc003ncd.1	-	18	3133	c.2933A>G	c.(2932-2934)AAT>AGT	p.N978S	NUP153_uc011dje.1_Missense_Mutation_p.N1009S|NUP153_uc010jpl.1_Missense_Mutation_p.N936S	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	978					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			AAAATTATCATTCTTACTATC	0.323												
SLC44A4	80736	broad.mit.edu	37	6	31833651	31833651	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr6:31833651G>A	uc010jti.2	-	14	1552	c.1486C>T	c.(1486-1488)CGT>TGT	p.R496C	NEU1_uc003nxq.3_5'Flank|NEU1_uc010jtg.2_5'Flank|NEU1_uc003nxr.3_5'Flank|NEU1_uc010jth.2_5'Flank|NEU1_uc003nxs.3_5'Flank	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	496	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	CATCCTTACCGGAGTGTGCGG	0.602												
SCUBE3	222663	broad.mit.edu	37	6	35210049	35210049	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr6:35210049C>T	uc003okf.1	+	13	1492	c.1486C>T	c.(1486-1488)CTG>TTG	p.L496L	SCUBE3_uc003okg.1_Silent_p.L495L|SCUBE3_uc003okh.1_Silent_p.L383L	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	496					protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						CCGTTTGCACCTGCGAAACAA	0.527												
ABCC10	89845	broad.mit.edu	37	6	43415571	43415571	+	Silent	SNP	C	C	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr6:43415571C>G	uc003ouy.1	+	18	4070	c.3855C>G	c.(3853-3855)GGC>GGG	p.G1285G	ABCC10_uc003ouz.1_Silent_p.G1257G|ABCC10_uc010jyo.1_Silent_p.G391G	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	1285	ABC transporter 2.|ATP 2 (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CAGGCTCCGGCAAGTCTTCCC	0.652												
TDRD6	221400	broad.mit.edu	37	6	46660186	46660186	+	Silent	SNP	C	C	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr6:46660186C>A	uc003oyj.2	+	1	4321	c.4321C>A	c.(4321-4323)CGG>AGG	p.R1441R	TDRD6_uc010jze.2_Silent_p.R1435R	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1441					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			CTTTTCCCAACGGACCAGCGA	0.388												
IMPG1	3617	broad.mit.edu	37	6	76751766	76751766	+	Nonsense_Mutation	SNP	C	C	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr6:76751766C>A	uc003pik.1	-	2	275	c.145G>T	c.(145-147)GAA>TAA	p.E49*		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	49					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TACATTTTTTCAGTACTTTCA	0.353												
UBE2CBP	90025	broad.mit.edu	37	6	83748171	83748171	+	Missense_Mutation	SNP	G	G	A	rs147405452	byFrequency	TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr6:83748171G>A	uc003pjp.2	-	5	739	c.631C>T	c.(631-633)CGT>TGT	p.R211C	UBE2CBP_uc011dyx.1_RNA|UBE2CBP_uc003pjr.2_Missense_Mutation_p.R179C	NM_198920	NP_944602	Q7Z6J8	UB2CB_HUMAN	ubiquitin-conjugating enzyme E2C binding	211						cytoplasm	ligase activity			ovary(1)	1		all_cancers(76;0.000374)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0548)		BRCA - Breast invasive adenocarcinoma(397;0.0944)		ACCTTGCAACGCTTACAAATT	0.328												
PRDM13	59336	broad.mit.edu	37	6	100060991	100060991	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr6:100060991C>T	uc003pqg.1	+	4	741	c.480C>T	c.(478-480)TGC>TGT	p.C160C		NM_021620	NP_067633	Q9H4Q3	PRD13_HUMAN	PR domain containing 13	160					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(76;1.64e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0598)		GTTTCCACTGCGTGTTCAGCG	0.627												
FOXO3	2309	broad.mit.edu	37	6	108985242	108985242	+	Silent	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr6:108985242G>A	uc003psk.2	+	3	1522	c.1206G>A	c.(1204-1206)TCG>TCA	p.S402S	FOXO3_uc003psn.2_Intron|FOXO3_uc003psm.2_Silent_p.S402S|FOXO3_uc011ean.1_Silent_p.S182S|FOXO3_uc010kdj.1_Silent_p.S182S	NM_201559	NP_963853	O43524	FOXO3_HUMAN	forkhead box O3A	402					antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(4)|lung(2)	6		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		CCCAGCCATCGCCCACTGGGG	0.582												
TRDN	10345	broad.mit.edu	37	6	123892170	123892170	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr6:123892170A>C	uc003pzj.1	-	2	152	c.130T>G	c.(130-132)TTC>GTC	p.F44V	TRDN_uc003pzk.1_Missense_Mutation_p.F44V|TRDN_uc003pzl.1_Missense_Mutation_p.F44V|TRDN_uc010ken.2_Missense_Mutation_p.F44V|TRDN_uc010keo.1_Missense_Mutation_p.F44V	NM_006073	NP_006064	Q13061	TRDN_HUMAN	triadin	44	Cytoplasmic.				muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.184)		GGGGAGCTGAACGTCGTCACT	0.463												
C6orf174	387104	broad.mit.edu	37	6	127837188	127837188	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr6:127837188G>A	uc003qbd.2	-	2	1437	c.572C>T	c.(571-573)CCG>CTG	p.P191L		NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	191	Gly-rich.					integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		CCTGGGCGGCGGCGGCTGCGG	0.637												
SHPRH	257218	broad.mit.edu	37	6	146244889	146244889	+	Silent	SNP	C	C	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr6:146244889C>G	uc003qlf.2	-	18	3834	c.3435G>C	c.(3433-3435)GTG>GTC	p.V1145V	SHPRH_uc003qld.2_Silent_p.V1154V|SHPRH_uc003qle.2_Silent_p.V1154V|SHPRH_uc003qlg.1_Silent_p.V701V|SHPRH_uc003qlh.2_Silent_p.V70V|SHPRH_uc003qli.1_Silent_p.V70V	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	1145					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		CTCTGTGGATCACATTTAGCC	0.363												
GRM1	2911	broad.mit.edu	37	6	146720447	146720447	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr6:146720447G>A	uc010khw.1	+	8	2742	c.2272G>A	c.(2272-2274)GGC>AGC	p.G758S	GRM1_uc010khv.1_Missense_Mutation_p.G758S|GRM1_uc003qll.2_Missense_Mutation_p.G758S|GRM1_uc011edz.1_Missense_Mutation_p.G758S|GRM1_uc011eea.1_Missense_Mutation_p.G758S	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	758	Helical; Name=5; (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GGCCCCTTTGGGCTACAATGG	0.512												
PARK2	5071	broad.mit.edu	37	6	162206908	162206908	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr6:162206908C>A	uc003qtx.3	-	7	901	c.767G>T	c.(766-768)CGC>CTC	p.R256L	PARK2_uc003qtv.3_RNA|PARK2_uc010kkd.2_Missense_Mutation_p.R65L|PARK2_uc003qtw.3_Missense_Mutation_p.R65L|PARK2_uc003qty.3_Missense_Mutation_p.R228L|PARK2_uc003qtz.3_Missense_Mutation_p.R107L|PARK2_uc010kke.1_Missense_Mutation_p.R256L|PARK2_uc011egf.1_5'UTR	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	256	RING-type 1; atypical.				aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		AATCACGTGGCGGGAGTTGCA	0.502												
MMD2	221938	broad.mit.edu	37	7	4949553	4949553	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr7:4949553C>T	uc003sno.3	-	6	764	c.568G>A	c.(568-570)GTC>ATC	p.V190I	MMD2_uc003snl.1_RNA|MMD2_uc003snn.3_Missense_Mutation_p.V166I|MMD2_uc010ksq.2_Missense_Mutation_p.V166I	NM_001100600	NP_001094070	Q8IY49	PAQRA_HUMAN	monocyte to macrophage	190	Helical; (Potential).					integral to membrane	receptor activity			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.097)|OV - Ovarian serous cystadenocarcinoma(56;3.4e-14)		CCCATTACGACGTAGCAGAGA	0.532												
OSBPL3	26031	broad.mit.edu	37	7	24892212	24892212	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr7:24892212C>T	uc003sxf.2	-	11	1474	c.1069G>A	c.(1069-1071)GAG>AAG	p.E357K	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Missense_Mutation_p.E357K|OSBPL3_uc003sxh.2_Missense_Mutation_p.E326K|OSBPL3_uc003sxi.2_Missense_Mutation_p.E326K|OSBPL3_uc003sxj.1_Missense_Mutation_p.E122K|OSBPL3_uc003sxk.1_Missense_Mutation_p.E91K	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	357					lipid transport		lipid binding|protein binding			skin(1)	1						TTCTCTCTCTCCGCTGACATG	0.408												
PCLO	27445	broad.mit.edu	37	7	82544081	82544081	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr7:82544081T>G	uc003uhx.2	-	7	13510	c.13221A>C	c.(13219-13221)GAA>GAC	p.E4407D	PCLO_uc003uhv.2_Missense_Mutation_p.E4407D|PCLO_uc010lec.2_Missense_Mutation_p.E1372D	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4338					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TCCGTGATTCTTCCCTCATGT	0.507												
SAMD9L	219285	broad.mit.edu	37	7	92763852	92763852	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr7:92763852G>T	uc003umh.1	-	5	2649	c.1433C>A	c.(1432-1434)ACT>AAT	p.T478N	SAMD9L_uc003umj.1_Missense_Mutation_p.T478N|SAMD9L_uc003umi.1_Missense_Mutation_p.T478N|SAMD9L_uc010lfb.1_Missense_Mutation_p.T478N|SAMD9L_uc003umk.1_Missense_Mutation_p.T478N|SAMD9L_uc010lfc.1_Missense_Mutation_p.T478N|SAMD9L_uc010lfd.1_Missense_Mutation_p.T478N|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	478										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CCACATGTTAGTTGTCTTGTC	0.408												
DENND2A	27147	broad.mit.edu	37	7	140285420	140285420	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr7:140285420G>A	uc010lnj.2	-	3	1359	c.1214C>T	c.(1213-1215)CCC>CTC	p.P405L	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.P405L|DENND2A_uc003vvw.2_Missense_Mutation_p.P405L|DENND2A_uc003vvx.2_Missense_Mutation_p.P405L	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	405										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					GGAAGAGGTGGGAGAAGCAGG	0.527												
OR9A2	135924	broad.mit.edu	37	7	142723354	142723354	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr7:142723354C>T	uc003wcc.1	-	1	866	c.866G>A	c.(865-867)CGG>CAG	p.R289Q		NM_001001658	NP_001001658	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A,	289	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.059)					TTTGTCATTCCGAAGAGTAAA	0.448												
CASP2	835	broad.mit.edu	37	7	143001810	143001810	+	Silent	SNP	C	C	T	rs142190608	byFrequency	TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr7:143001810C>T	uc003wco.2	+	10	1308	c.1161C>T	c.(1159-1161)ATC>ATT	p.I387I	CASP2_uc003wcp.2_3'UTR|CASP2_uc011kta.1_Silent_p.I271I|CASP2_uc003wcq.2_RNA|CASP2_uc011ktb.1_Silent_p.I137I	NM_032982	NP_116764	P42575	CASP2_HUMAN	caspase 2 isoform 1 preproprotein	387					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			lung(2)|ovary(1)	3	Melanoma(164;0.059)					CCTGGTACATCGAGGCTCTTG	0.557												
CSMD1	64478	broad.mit.edu	37	8	2967856	2967856	+	Silent	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr8:2967856G>A	uc011kwk.1	-	43	6825	c.6435C>T	c.(6433-6435)GCC>GCT	p.A2145A	CSMD1_uc011kwj.1_Silent_p.A1537A|CSMD1_uc010lrg.2_Silent_p.A213A	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2145	Extracellular (Potential).|Sushi 12.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ACCCACAAGGGGCTGCAAAGG	0.453												
GATA4	2626	broad.mit.edu	37	8	11614478	11614478	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr8:11614478C>T	uc003wuc.2	+	6	1586	c.1032C>T	c.(1030-1032)AGC>AGT	p.S344S	GATA4_uc003wub.1_Silent_p.S138S|GATA4_uc011kxc.1_Silent_p.S345S	NM_002052	NP_002043	P43694	GATA4_HUMAN	GATA binding protein 4	344					atrial septum primum morphogenesis|atrial septum secundum morphogenesis|blood coagulation|cardiac right ventricle morphogenesis|cell-cell signaling|embryonic foregut morphogenesis|embryonic heart tube anterior/posterior pattern formation|endocardial cushion development|endoderm development|heart looping|intestinal epithelial cell differentiation|male gonad development|positive regulation of angiogenesis|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|response to drug|transcription from RNA polymerase II promoter|ventricular septum development	nucleoplasm	activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(15;0.0839)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.199)		CTCCCGCCAGCGGTGCTTCCA	0.617												
KCNU1	157855	broad.mit.edu	37	8	36763262	36763262	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr8:36763262G>T	uc010lvw.2	+	20	2133	c.2046G>T	c.(2044-2046)CAG>CAT	p.Q682H	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	682	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ATTCTGACCAGCTTGATAGCA	0.413												
PLAT	5327	broad.mit.edu	37	8	42036423	42036423	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr8:42036423C>T	uc003xos.2	-	13	1731	c.1522G>A	c.(1522-1524)GCC>ACC	p.A508T	PLAT_uc010lxf.1_Missense_Mutation_p.A425T|PLAT_uc010lxg.1_Missense_Mutation_p.A333T|PLAT_uc003xot.2_Missense_Mutation_p.A462T|PLAT_uc011lcm.1_Missense_Mutation_p.A419T|PLAT_uc011lcn.1_Missense_Mutation_p.A382T	NM_000930	NP_000921	P00750	TPA_HUMAN	plasminogen activator, tissue isoform 1	508	Peptidase S1.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|skin(1)	2	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ACCTGGCAGGCGTCGTGCAAG	0.567												
ZFHX4	79776	broad.mit.edu	37	8	77767332	77767332	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr8:77767332G>T	uc003yav.2	+	10	8427	c.8040G>T	c.(8038-8040)CAG>CAT	p.Q2680H	ZFHX4_uc003yau.1_Missense_Mutation_p.Q2725H|ZFHX4_uc003yaw.1_Missense_Mutation_p.Q2680H	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2680						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAAGCCCACAGAAATACATCT	0.428										HNSCC(33;0.089)		
INTS8	55656	broad.mit.edu	37	8	95839622	95839622	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr8:95839622A>G	uc003yhb.2	+	3	563	c.437A>G	c.(436-438)TAT>TGT	p.Y146C	INTS8_uc003yha.1_Missense_Mutation_p.Y146C|INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_5'Flank	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	146					snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					GTACTTCTCTATAATAGATGG	0.423												
RIMS2	9699	broad.mit.edu	37	8	104987701	104987701	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr8:104987701G>T	uc003yls.2	+	14	2469	c.2228G>T	c.(2227-2229)AGA>ATA	p.R743I	RIMS2_uc003ylp.2_Missense_Mutation_p.R965I|RIMS2_uc003ylw.2_Missense_Mutation_p.R757I|RIMS2_uc003ylq.2_Missense_Mutation_p.R757I|RIMS2_uc003ylr.2_Missense_Mutation_p.R804I|RIMS2_uc003ylt.2_Missense_Mutation_p.R350I	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1027					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GGAAGGACTAGATCATGGTCA	0.363										HNSCC(12;0.0054)		
DPYS	1807	broad.mit.edu	37	8	105436539	105436539	+	Silent	SNP	T	T	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr8:105436539T>G	uc003yly.3	-	7	1300	c.1171A>C	c.(1171-1173)AGA>CGA	p.R391R		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	391					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTTCCTTTTCTTGGATAGAGA	0.373												
LRP12	29967	broad.mit.edu	37	8	105509626	105509626	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr8:105509626T>G	uc003yma.2	-	5	1249	c.1154A>C	c.(1153-1155)AAC>ACC	p.N385T	LRP12_uc003ymb.2_Missense_Mutation_p.N366T|LRP12_uc003ylz.2_5'Flank	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	385	Extracellular (Potential).|LDL-receptor class A 3.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			ACACCCCCAGTTACCTCCACA	0.443												
EXT1	2131	broad.mit.edu	37	8	118819534	118819534	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr8:118819534G>A	uc003yok.1	-	9	2578	c.1805C>T	c.(1804-1806)TCT>TTT	p.S602F		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	602	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			CCGCTCCTTAGAGTTATCCCA	0.537			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome			
TG	7038	broad.mit.edu	37	8	134107329	134107329	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr8:134107329G>T	uc003ytw.2	+	42	7322	c.7281G>T	c.(7279-7281)GAG>GAT	p.E2427D	TG_uc010mdw.2_Missense_Mutation_p.E1186D|TG_uc011ljb.1_Missense_Mutation_p.E796D|TG_uc011ljc.1_Missense_Mutation_p.E560D|SLA_uc003ytz.2_Intron|SLA_uc011lje.1_Intron|SLA_uc011ljf.1_Intron|SLA_uc011ljg.1_Intron|SLA_uc010mea.2_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2427					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TCAGCCATGAGAGGGCTCAGC	0.602												
GLIS3	169792	broad.mit.edu	37	9	4286252	4286252	+	Silent	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr9:4286252G>A	uc003zhx.1	-	2	887	c.174C>T	c.(172-174)CTC>CTT	p.L58L	GLIS3_uc003zic.1_Silent_p.L58L|GLIS3_uc003zie.1_Silent_p.L58L|GLIS3_uc010mhh.1_Intron|GLIS3_uc003zid.1_5'UTR|GLIS3_uc010mhi.1_Intron|GLIS3_uc003zif.1_5'UTR|GLIS3_uc003zig.1_Intron|GLIS3_uc003zih.1_Intron|GLIS3_uc003zii.1_Silent_p.L58L	NM_001042413	NP_001035878	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		TCTTGAGATGGAGGTTGTTAG	0.592												
RANBP6	26953	broad.mit.edu	37	9	6014769	6014769	+	Missense_Mutation	SNP	C	C	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr9:6014769C>G	uc003zjr.2	-	1	850	c.839G>C	c.(838-840)AGT>ACT	p.S280T	RANBP6_uc011lmf.1_Intron|RANBP6_uc003zjs.2_Intron	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	280					protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		CTGCAGATTACTAAGCCTAGA	0.423												
DNM1	1759	broad.mit.edu	37	9	131010944	131010944	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr9:131010944G>A	uc011mau.1	+	19	2075	c.1988G>A	c.(1987-1989)CGG>CAG	p.R663Q	DNM1_uc011mat.1_Missense_Mutation_p.R663Q|DNM1_uc004bub.1_Missense_Mutation_p.R36Q|DNM1_uc004buc.1_Missense_Mutation_p.R130Q|DNM1_uc004bud.3_RNA	NM_004408	NP_004399	Q05193	DYN1_HUMAN	dynamin 1 isoform 1	663	GED.				receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			ovary(2)	2						GAGACCATCCGGAATCTTGTG	0.537												
NLGN4X	57502	broad.mit.edu	37	X	5811502	5811502	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chrX:5811502T>C	uc010ndh.2	-	6	2308	c.1807A>G	c.(1807-1809)ATA>GTA	p.I603V	NLGN4X_uc004crp.2_Missense_Mutation_p.I623V|NLGN4X_uc004crq.2_Missense_Mutation_p.I603V|NLGN4X_uc010ndi.2_Missense_Mutation_p.I640V|NLGN4X_uc004crr.2_Missense_Mutation_p.I603V|NLGN4X_uc010ndj.2_Missense_Mutation_p.I603V	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	603	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						TACTGGAATATCTCGTTCAAG	0.488												
MAP3K15	389840	broad.mit.edu	37	X	19431478	19431478	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chrX:19431478T>C	uc004czk.1	-	11	1659	c.22A>G	c.(22-24)AAT>GAT	p.N8D	MAP3K15_uc004czj.1_5'UTR	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	Error:Variant_position_missing_in_Q6ZN16_after_alignment							ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)					TCCTTACCATTTCTGTGGGTG	0.393												
MAGEB18	286514	broad.mit.edu	37	X	26157428	26157428	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chrX:26157428A>G	uc004dbq.1	+	2	513	c.326A>G	c.(325-327)AAG>AGG	p.K109R		NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	109	MAGE.						protein binding			central_nervous_system(1)	1						CCTTTAAACAAGAAAGTAGTG	0.418												
MAGEB6	158809	broad.mit.edu	37	X	26212528	26212528	+	Missense_Mutation	SNP	C	C	T	rs142927857		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chrX:26212528C>T	uc004dbr.2	+	2	714	c.565C>T	c.(565-567)CGC>TGC	p.R189C	MAGEB6_uc010ngc.1_5'UTR	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	189										ovary(3)	3						CATTTTTAAGCGCTTAAGCAA	0.468												
DCAF8L1	139425	broad.mit.edu	37	X	27998645	27998645	+	Silent	SNP	T	T	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chrX:27998645T>C	uc004dbx.1	-	1	922	c.807A>G	c.(805-807)GAA>GAG	p.E269E		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	269	WD 2.									ovary(3)|skin(1)	4						CATTAATTAGTTCTGCTACCC	0.493												
MAGEB2	4113	broad.mit.edu	37	X	30237209	30237209	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chrX:30237209T>G	uc004dbz.2	+	2	615	c.512T>G	c.(511-513)GTC>GGC	p.V171G		NM_002364	NP_002355	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	171	MAGE.						protein binding			ovary(1)	1						CTGAATAAAGTCAACCCCAAC	0.502												
DMD	1756	broad.mit.edu	37	X	31893328	31893328	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chrX:31893328G>T	uc004dda.1	-	48	7319	c.7075C>A	c.(7075-7077)CAA>AAA	p.Q2359K	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Missense_Mutation_p.Q1015K|DMD_uc004dcx.2_Missense_Mutation_p.Q1018K|DMD_uc004dcz.2_Missense_Mutation_p.Q2236K|DMD_uc004dcy.1_Missense_Mutation_p.Q2355K|DMD_uc004ddb.1_Missense_Mutation_p.Q2351K|DMD_uc010ngn.1_RNA	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2359			Missing (in DMD).		muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGTCCTTCTTGGTTTGGTTGG	0.333												
MAGEB16	139604	broad.mit.edu	37	X	35820607	35820607	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chrX:35820607C>T	uc010ngt.1	+	2	573	c.294C>T	c.(292-294)TCC>TCT	p.S98S		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	98										lung(3)|ovary(2)|breast(1)|skin(1)	7						GTCCAAGCTCCTCAGAGGATA	0.478												
BCOR	54880	broad.mit.edu	37	X	39933151	39933151	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chrX:39933151G>A	uc004den.3	-	4	1740	c.1448C>T	c.(1447-1449)CCG>CTG	p.P483L	BCOR_uc004dep.3_Missense_Mutation_p.P483L|BCOR_uc004deo.3_Missense_Mutation_p.P483L|BCOR_uc004dem.3_Missense_Mutation_p.P483L|BCOR_uc004deq.3_Missense_Mutation_p.P483L	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	483					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						TGTTTCTTTCGGAATCTCACT	0.517												
CHST7	56548	broad.mit.edu	37	X	46433819	46433819	+	Silent	SNP	C	C	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chrX:46433819C>T	uc004dgt.2	+	1	628	c.453C>T	c.(451-453)GGC>GGT	p.G151G		NM_019886	NP_063939	Q9NS84	CHST7_HUMAN	chondroitin 6-sulfotransferase 7	151	Lumenal (Potential).				chondroitin sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity|N-acetylglucosamine 6-O-sulfotransferase activity			breast(3)	3						GCTTGCAGGGCGCGCTGCGCG	0.507												
EBP	10682	broad.mit.edu	37	X	48386665	48386665	+	Silent	SNP	C	C	T	rs147786080		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chrX:48386665C>T	uc004djx.3	+	5	718	c.513C>T	c.(511-513)CGC>CGT	p.R171R	EBP_uc004djy.3_Silent_p.R171R|EBP_uc004djz.2_Silent_p.R171R	NM_006579	NP_006570	Q15125	EBP_HUMAN	emopamil binding protein (sterol isomerase)	171					cholesterol biosynthetic process|skeletal system development	endoplasmic reticulum membrane|integral to plasma membrane	cholestenol delta-isomerase activity|drug transmembrane transporter activity|steroid delta-isomerase activity|transmembrane receptor activity			ovary(1)	1						CAGAGCACCGCGACGGATTCC	0.582												
PRICKLE3	4007	broad.mit.edu	37	X	49032238	49032238	+	Silent	SNP	A	A	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chrX:49032238A>C	uc004dmy.1	-	9	1658	c.1632T>G	c.(1630-1632)TCT>TCG	p.S544S	PRICKLE3_uc011mmv.1_Silent_p.S476S|PRICKLE3_uc011mmw.1_Silent_p.S463S|PRICKLE3_uc011mmx.1_Silent_p.S506S	NM_006150	NP_006141	O43900	PRIC3_HUMAN	LIM domain only 6	544	Poly-Ser.						protein binding|zinc ion binding			breast(1)	1						AGCTGGAGCAAGATTCCGAGT	0.502												
ITIH5L	347365	broad.mit.edu	37	X	54785377	54785377	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chrX:54785377T>G	uc004dtj.2	-	8	1160	c.1130A>C	c.(1129-1131)AAC>ACC	p.N377T		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	377	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						AGGCTCCTGGTTGCTATGGTT	0.577												
OGT	8473	broad.mit.edu	37	X	70767789	70767789	+	Silent	SNP	G	G	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chrX:70767789G>A	uc004eaa.1	+	5	781	c.564G>A	c.(562-564)CCG>CCA	p.P188P	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Silent_p.P178P|OGT_uc004eac.2_Silent_p.P49P|OGT_uc004ead.2_5'UTR	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	188	TPR 4.				cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					AGACGCAACCGAACTTTGCAG	0.393												
IL1RAPL2	26280	broad.mit.edu	37	X	104478507	104478507	+	Nonsense_Mutation	SNP	C	C	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chrX:104478507C>A	uc004elz.1	+	4	1118	c.362C>A	c.(361-363)TCA>TAA	p.S121*		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	121	Ig-like C2-type 1.|Extracellular (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						TACAGAAACTCAACATATTGC	0.373												
IFT88	8100	broad.mit.edu	37	13	21217687	21217689	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr13:21217687_21217689delAGG	uc001unh.2	+	21	2199_2201	c.1803_1805delAGG	c.(1801-1806)CTAGGA>CTA	p.G602del	IFT88_uc001uni.2_In_Frame_Del_p.G593del|IFT88_uc001unj.2_In_Frame_Del_p.G592del|IFT88_uc010tcq.1_In_Frame_Del_p.G573del	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	602	TPR 10.				cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		TATCTAAGCTAGGAGAATTATAT	0.345												
APC	324	broad.mit.edu	37	5	112175676	112175677	+	Frame_Shift_Ins	INS	-	-	AG	rs121913334		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr5:112175675_112175676A>AAG	uc003kpz.4	+	16	4577_4578	c.4384_4385A>AAG	c.(4384-4386)aagfs	p.K1462fs	APC_uc011cvt.2_Frame_Shift_Ins_p.K1444fs|APC_uc003kpy.4_Frame_Shift_Ins_p.K1462fs|APC_uc010jbz.3_Frame_Shift_Ins_p.K1179fs|APC_uc010jca.3_Frame_Shift_Ins_p.K762fs	NM_001127510	NP_001120982	P25054	APC_HUMAN	Homo sapiens adenomatous polyposis coli (APC), transcript variant 2, mRNA.	1462	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|adherens junction|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.S1465fs*3(16)|p.K1462fs*6(5)|p.E1461*(3)|p.K1462fs*5(2)|p.K1462fs*10(2)|p.?(1)|p.K1454fs*3(1)|p.K1192fs*3(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TACTGCTGAAAAGAGAGAGAGT	0.450		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)		
HIST1H2AD	3013	broad.mit.edu	37	6	26199356	26199357	+	Frame_Shift_Ins	INS	-	-	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr6:26199355_26199356G>GT	uc003ngw.3	-	0	116_117	c.116_117C>AC	c.(115-117)aacfs	p.N39fs	HIST1H3D_uc003ngv.3_5'UTR|HIST1H3D_uc021ymt.1_5'Flank|HIST1H2BF_uc003ngx.3_5'Flank	NM_021065	NP_066409	P20671	H2A1D_HUMAN	Homo sapiens histone cluster 1, H2ad (HIST1H2AD), mRNA.	39					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	6		all_hematologic(11;0.196)				GCTCGGAGTAGTTGCCCTTGCG	0.688												
RAB5B	5869	broad.mit.edu	37	12	56384549	56384549	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr12:56384548_56384548AC>A	uc001siv.3	+	3	578	c.398_398AC>A	c.(397-399)aacfs	p.N133fs	RAB5B_uc001siw.3_Frame_Shift_Del_p.N133fs|RAB5B_uc010spz.2_Intron|RAB5B_uc009zog.3_Frame_Shift_Del_p.N73fs	NM_001252036	NP_001238965	P61020	RAB5B_HUMAN	Homo sapiens RAB5B, member RAS oncogene family (RAB5B), transcript variant 2, mRNA.	133					protein transport|small GTPase mediated signal transduction	early endosome membrane|melanosome|membrane fraction|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity	p.G132G(1)		endometrium(1)|large_intestine(1)|liver(2)|lung(4)|upper_aerodigestive_tract(1)	9			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.235)			CTGGCAGGGAACAAAGCTGAC	0.502												
TP53	7157	broad.mit.edu	37	17	7579585	7579585	+	Frame_Shift_Del	DEL	G	G	-			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	61ee42d5-0a9d-4c64-a20a-93bfcdba7a11	g.chr17:7579584_7579584AG>A	uc002gim.2	-	3	297	c.103_103CT>T	c.(103-105)ttgfs	p.L35fs	TP53_uc002gig.1_Frame_Shift_Del_p.L35fs|TP53_uc002gih.3_Frame_Shift_Del_p.L35fs|TP53_uc010cne.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cni.1_Frame_Shift_Del_p.L35fs|TP53_uc010cnh.1_Frame_Shift_Del_p.L35fs|TP53_uc002gij.2_Frame_Shift_Del_p.L35fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.2_5'UTR|TP53_uc010cnk.1_Frame_Shift_Del_p.L50fs	NM_001126112	NP_001119587	P04637	P53_HUMAN	Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA.	35	Interaction with HRMT1L2.|Transcription activation (acidic).		L -> F (in sporadic cancers; somatic mutation).		DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|Ras protein signal transduction|activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to UV|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|determination of adult lifespan|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|regulation of mitochondrial membrane permeability|replicative senescence|response to X-ray|response to antibiotic|response to gamma radiation	PML body|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|protein complex|replication fork	ATP binding|DNA strand annealing activity|RNA polymerase II transcription factor binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|histone acetyltransferase binding|p53 binding|protease binding|protein N-terminus binding|protein binding|protein heterodimerization activity|protein kinase binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.L35fs*9(4)|p.L35F(3)|p.L35fs*8(2)|p.P34L(2)|p.L35fs*10(1)|p.?(1)|p.S33fs*23(1)|p.P34fs*8(1)|p.P36fs*7(1)|p.P13fs*18(1)|p.S33fs*6(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGGGACGGCAAGGGGGACTGT	0.597		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
