Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PRAMEF11	440560	broad.mit.edu	37	1	12887606	12887606	+	Missense_Mutation	SNP	C	C	G	rs58074988		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr1:12887606C>G	uc001auk.2	-	3	447	c.251G>C	c.(250-252)TGC>TCC	p.C84S		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	84											0						ATTGAGGAAGCACCCATGGGC	0.483		NA											6	194					0	0	0	0
C1orf89	79363	broad.mit.edu	37	1	16559457	16559457	+	Silent	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr1:16559457G>A	uc001ayd.2	-	3	743	c.321C>T	c.(319-321)GTC>GTT	p.V107V		NM_030907	NP_112169	Q9BU20	RSG1_HUMAN	hypothetical protein LOC79363	107	Small GTPase-like.				cellular protein localization|cilium assembly|exocytosis|protein transport|regulation of exocytosis|regulation of vesicle fusion|small GTPase mediated signal transduction	cilium|microtubule basal body	GTP binding				0		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;3.2e-07)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;9.12e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0114)|READ - Rectum adenocarcinoma(331;0.0649)		GAAACATGACGACACGGCTGC	0.577		NA											22	58					0	0	0	0
AKR7L	246181	broad.mit.edu	37	1	19596120	19596120	+	Silent	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr1:19596120G>A	uc010ocx.1	-	5	561	c.561C>T	c.(559-561)CTC>CTT	p.L187L	AKR7L_uc010ocy.1_Intron	NM_201252	NP_957704			aflatoxin B1 aldehyde reductase 3 isoform 1												0						CAAAGTGCCTGAGGCAGGGGA	0.602		NA											20	42					0	0	0	0
MAP3K6	9064	broad.mit.edu	37	1	27682188	27682188	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr1:27682188G>A	uc001bny.1	-	28	4009	c.3760C>T	c.(3760-3762)CGA>TGA	p.R1254*	MAP3K6_uc009vsw.1_Nonsense_Mutation_p.R1246*	NM_004672	NP_004663	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase	1254					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|lung(3)|ovary(1)|central_nervous_system(1)	9		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		AGGTCATCTCGAGTGGCATAG	0.512		NA											9	71					0	0	0	0
MACF1	23499	broad.mit.edu	37	1	39812685	39812685	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr1:39812685C>A	uc010oiu.1	+	5	6069	c.5938C>A	c.(5938-5940)CTG>ATG	p.L1980M	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	3545					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAAAGCTCAGCTGGATGCTCT	0.413		NA											14	36					9.31e-06	9.82e-06	1	0
YBX1	4904	broad.mit.edu	37	1	43166568	43166568	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr1:43166568A>G	uc001chs.2	+	7	1028	c.857A>G	c.(856-858)AAT>AGT	p.N286S		NM_004559	NP_004550	P67809	YBOX1_HUMAN	nuclease sensitive element binding protein 1	286					CRD-mediated mRNA stabilization|negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|positive regulation of cell division|transcription from RNA polymerase II promoter	CRD-mediated mRNA stability complex|extracellular region|histone pre-mRNA 3'end processing complex|nucleoplasm|stress granule|U12-type spliceosomal complex	double-stranded DNA binding|protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			ovary(4)|upper_aerodigestive_tract(1)	5	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CGCAACTTCAATTACCGACGC	0.527		NA											12	33					0	0	0	0
TDRD10	126668	broad.mit.edu	37	1	154516537	154516537	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr1:154516537C>T	uc009wow.2	+	9	1440	c.602C>T	c.(601-603)ACG>ATG	p.T201M	TDRD10_uc001ffd.2_Missense_Mutation_p.T201M|TDRD10_uc001ffe.2_Missense_Mutation_p.T122M	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	201							nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTGCTGGTGACGAGTATCGTC	0.622		NA											25	48					0	0	0	0
CCNJ	54619	broad.mit.edu	37	10	97817643	97817643	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr10:97817643A>G	uc001klm.2	+	6	1123	c.764A>G	c.(763-765)CAG>CGG	p.Q255R	uc001klg.1_Intron|uc001klj.1_Intron|uc009xvb.1_Intron|CCNJ_uc010qoq.1_Missense_Mutation_p.Q266R|CCNJ_uc001kln.2_Missense_Mutation_p.Q254R	NM_019084	NP_061957	Q5T5M9	CCNJ_HUMAN	cyclin J isoform 2	255						nucleus				ovary(1)	1				Epithelial(162;6.1e-08)|all cancers(201;2.32e-06)		GCAGGACCTCAGTCAGCGCAA	0.468		NA											31	17					0	0	0	0
HRAS	3265	broad.mit.edu	37	11	534285	534285	+	Missense_Mutation	SNP	C	C	A	rs104894226		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr11:534285C>A	uc001lpv.2	-	2	226	c.38G>T	c.(37-39)GGT>GTT	p.G13V	HRAS_uc010qvw.1_Missense_Mutation_p.G13V|HRAS_uc010qvx.1_Missense_Mutation_p.G13V|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	13	GTP.		G -> D (in FCSS).|G -> C (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G13R(33)|p.G13V(10)|p.G13D(9)|p.G13S(9)|p.G13C(6)|p.G13G(1)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	CTTGCCCACACCGCCGGCGCC	0.642		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			21	12					1.98e-07	2.12e-07	1	0
HRAS	3265	broad.mit.edu	37	11	534291	534291	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr11:534291G>T	uc001lpv.2	-	2	220	c.32C>A	c.(31-33)GCC>GAC	p.A11D	HRAS_uc010qvw.1_Missense_Mutation_p.A11D|HRAS_uc010qvx.1_Missense_Mutation_p.A11D|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	11	GTP.				activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.A11A(2)|p.G10_A11insG(1)|p.A11S(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	CACACCGCCGGCGCCCACCAC	0.652		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			19	11					3.99e-14	4.53e-14	1	0
DNHD1	144132	broad.mit.edu	37	11	6593070	6593070	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr11:6593070T>A	uc001mdw.3	+	43	14680	c.14116T>A	c.(14116-14118)TCG>ACG	p.S4706T	DNHD1_uc001mea.3_Missense_Mutation_p.S975T|DNHD1_uc001meb.2_3'UTR|DNHD1_uc001mec.2_Missense_Mutation_p.S974T|DNHD1_uc010rao.1_Missense_Mutation_p.S964T|DNHD1_uc009yfg.2_Missense_Mutation_p.S331T	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4706					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GACTGTGTACTCGTGTCCTGT	0.627		NA											13	54					0	0	0	0
ANO5	203859	broad.mit.edu	37	11	22276979	22276979	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr11:22276979G>C	uc001mqi.2	+	13	1560	c.1243G>C	c.(1243-1245)GTG>CTG	p.V415L	ANO5_uc001mqj.2_Missense_Mutation_p.V414L	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	415	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						ATGGGACCTGGTGGACTTTGA	0.358		NA											52	82					0	0	0	0
MARK2	2011	broad.mit.edu	37	11	63668102	63668102	+	Silent	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr11:63668102G>A	uc001nxw.2	+	9	1419	c.840G>A	c.(838-840)CTG>CTA	p.L280L	MARK2_uc001nxx.2_Silent_p.L280L|MARK2_uc001nxy.2_Silent_p.L280L|MARK2_uc001nxv.3_Silent_p.L280L|MARK2_uc001nxz.3_Silent_p.L247L|MARK2_uc009yoy.2_Silent_p.L247L	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	280	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						GTGAAAACCTGCTTAAGAAAT	0.507		NA											97	180					0	0	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43826253	43826253	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr12:43826253C>T	uc010skx.1	-	21	2950	c.2950G>A	c.(2950-2952)GGA>AGA	p.G984R	ADAMTS20_uc001rno.1_Missense_Mutation_p.G138R|ADAMTS20_uc001rnp.1_Missense_Mutation_p.G138R	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	984	TSP type-1 4.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTTTCCCCTCCTCCACAACTC	0.368		NA											18	35					0	0	0	0
LRP1	4035	broad.mit.edu	37	12	57601972	57601972	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr12:57601972A>G	uc001snd.2	+	77	12477	c.12011A>G	c.(12010-12012)CAC>CGC	p.H4004R		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	4004	LDL-receptor class B 32.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GACGAGCCCCACGCCATTGTG	0.657		NA											7	12					0	0	0	0
PAN3	255967	broad.mit.edu	37	13	28771372	28771372	+	Silent	SNP	A	A	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr13:28771372A>T	uc001urz.2	+	4	311	c.303A>T	c.(301-303)GGA>GGT	p.G101G	PAN3_uc010tdo.1_Silent_p.G247G|PAN3_uc001ury.2_5'UTR|PAN3_uc001urx.2_Intron	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease	247	Interaction with polyadenylate-binding protein.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		TTCCGATGGGATCAAAGGCAC	0.493		NA											5	7					0	0	0	0
DNAJC15	29103	broad.mit.edu	37	13	43597852	43597852	+	Silent	SNP	C	C	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr13:43597852C>T	uc001uyy.2	+	1	491	c.90C>T	c.(88-90)GAC>GAT	p.D30D		NM_013238	NP_037370	Q9Y5T4	DJC15_HUMAN	DNAJ domain-containing	30						integral to membrane	heat shock protein binding				0		Lung NSC(96;4.3e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0737)		CAGACGCCGACGTCGACCAGC	0.642		NA											4	9					0	0	0	0
ATP4B	496	broad.mit.edu	37	13	114304774	114304774	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr13:114304774G>A	uc001vtz.2	-	6	703	c.661C>T	c.(661-663)CCC>TCC	p.P221S		NM_000705	NP_000696	P51164	ATP4B_HUMAN	hydrogen/potassium-exchanging ATPase 4B	221	Extracellular (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	hydrogen:potassium-exchanging ATPase activity|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.00696)|all_epithelial(44;0.00347)|all_lung(25;0.0221)|Breast(118;0.0411)|Lung NSC(25;0.0839)	all cancers(43;0.171)		Rabeprazole(DB01129)	GTGCCGTTGGGAGGGTAGTAC	0.622		NA											24	37					0	0	0	0
TPPP2	122664	broad.mit.edu	37	14	21499180	21499180	+	Silent	SNP	C	C	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr14:21499180C>T	uc001vzh.2	+	3	371	c.183C>T	c.(181-183)AAC>AAT	p.N61N	NDRG2_uc010tll.1_Intron	NM_173846	NP_776245	P59282	TPPP2_HUMAN	tubulin polymerization-promoting protein family	61						cytoplasm					0	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		GGGCCAAGAACGCCCGAACCA	0.483		NA											12	23					0	0	0	0
TINF2	26277	broad.mit.edu	37	14	24709835	24709835	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr14:24709835G>A	uc001woa.3	-	6	1193	c.851C>T	c.(850-852)ACA>ATA	p.T284I	TINF2_uc010alm.2_Missense_Mutation_p.T108I|TINF2_uc001wob.3_Missense_Mutation_p.T284I|TINF2_uc010tof.1_Missense_Mutation_p.T249I|TINF2_uc001woc.3_3'UTR	NM_001099274	NP_001092744	Q9BSI4	TINF2_HUMAN	TERF1 (TRF1)-interacting nuclear factor 2	284					negative regulation of epithelial cell proliferation|negative regulation of protein ADP-ribosylation|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance|protein localization to chromosome, telomeric region|telomere assembly|telomere maintenance via telomere lengthening	nuclear telomere cap complex|nucleoplasm|perinucleolar chromocenter	protein binding|protein binding|telomeric DNA binding				0				GBM - Glioblastoma multiforme(265;0.0185)		CAGCATGACTGTGGGGCGCTC	0.552		NA							Ataxia_Pancytopenia_syndrome|Congenital_Dyskeratosis				17	28					0	0	0	0
TP53BP1	7158	broad.mit.edu	37	15	43720231	43720231	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr15:43720231C>T	uc001zrs.2	-	18	3944	c.3796G>A	c.(3796-3798)GAA>AAA	p.E1266K	TP53BP1_uc010udp.1_Missense_Mutation_p.E1266K|TP53BP1_uc001zrq.3_Missense_Mutation_p.E1271K|TP53BP1_uc001zrr.3_Missense_Mutation_p.E1271K|TP53BP1_uc010udq.1_Missense_Mutation_p.E1271K	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	1266					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		ACTTTTCTTTCTACTTCTGTT	0.308		NA						Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					39	90					0	0	0	0
SEC11A	23478	broad.mit.edu	37	15	85230875	85230875	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr15:85230875C>G	uc002blb.1	-	3	660	c.292G>C	c.(292-294)GTC>CTC	p.V98L	SEC11A_uc002blc.1_Missense_Mutation_p.V72L	NM_014300	NP_055115	P67812	SC11A_HUMAN	SEC11-like 1	98	Lumenal (Potential).				energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	endoplasmic reticulum membrane|integral to membrane|microsome	protein binding|serine-type peptidase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(143;0.199)			ATCTTCAAGACTCGGTGAACT	0.343		NA											21	75					0	0	0	0
CACNA1H	8912	broad.mit.edu	37	16	1265063	1265063	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr16:1265063G>A	uc002cks.2	+	28	5269	c.5021G>A	c.(5020-5022)CGT>CAT	p.R1674H	CACNA1H_uc002ckt.2_Missense_Mutation_p.R1668H|CACNA1H_uc002cku.2_Missense_Mutation_p.R380H|CACNA1H_uc010brj.2_Missense_Mutation_p.R385H|CACNA1H_uc002ckv.2_Missense_Mutation_p.R374H	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1674	IV.|Cytoplasmic (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	TTTGGGTTCCGTCGGTTCTTC	0.622		NA											7	10					0	0	0	0
TBC1D24	57465	broad.mit.edu	37	16	2546268	2546268	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr16:2546268G>A	uc002cql.2	+	2	259	c.119G>A	c.(118-120)CGC>CAC	p.R40H	TBC1D24_uc002cqk.2_Missense_Mutation_p.R40H|TBC1D24_uc002cqm.2_Missense_Mutation_p.R40H|TBC1D24_uc010bsm.2_5'Flank	NM_020705	NP_065756	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	40					neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity				0						CAGCTGGCGCGCCAGGGCTAC	0.642		NA											13	31					0	0	0	0
GRIN2A	2903	broad.mit.edu	37	16	9943686	9943686	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr16:9943686C>T	uc002czo.3	-	5	1803	c.1255G>A	c.(1255-1257)GTG>ATG	p.V419M	GRIN2A_uc010uym.1_Missense_Mutation_p.V419M|GRIN2A_uc010uyn.1_Missense_Mutation_p.V262M|GRIN2A_uc002czr.3_Missense_Mutation_p.V419M	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	419	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATGTCTTCCACGATGACGAAT	0.572		NA											24	45					0	0	0	0
ZFHX3	463	broad.mit.edu	37	16	72993515	72993515	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr16:72993515G>A	uc002fck.2	-	2	1203	c.530C>T	c.(529-531)GCG>GTG	p.A177V	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	177					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				CTTGCCCCCCGCGCCAGGGAG	0.637		NA											12	44					0	0	0	0
NEK8	284086	broad.mit.edu	37	17	27067575	27067575	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr17:27067575C>G	uc002hcp.2	+	11	1512	c.1512C>G	c.(1510-1512)ATC>ATG	p.I504M		NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	504	RCC1 3.					cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|pancreas(1)|liver(1)|skin(1)	6	Lung NSC(42;0.0158)					TATGTGGTATCGATTCCTCCA	0.587		NA											28	43					0	0	0	0
NF1	4763	broad.mit.edu	37	17	29657375	29657375	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr17:29657375C>T	uc002hgg.2	+	39	6004	c.5671C>T	c.(5671-5673)CAG>TAG	p.Q1891*	NF1_uc002hgh.2_Nonsense_Mutation_p.Q1870*|NF1_uc002hgi.1_Nonsense_Mutation_p.Q903*|NF1_uc010cso.2_Nonsense_Mutation_p.Q79*	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1891					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AATCGAGGGCCAGTTACTAGA	0.398		NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			5	69					0	0	0	0
NPEPPS	9520	broad.mit.edu	37	17	45663002	45663002	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr17:45663002A>G	uc002ilr.3	+	6	1008	c.785A>G	c.(784-786)GAT>GGT	p.D262G	NPEPPS_uc010wkt.1_Missense_Mutation_p.D258G|NPEPPS_uc010wku.1_Missense_Mutation_p.D226G|NPEPPS_uc010dba.1_Missense_Mutation_p.D107G|NPEPPS_uc010wkv.1_5'Flank	NM_006310	NP_006301	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	262					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0						AGGTCAAAAGATGGTGTGTGT	0.418		NA											45	101					0	0	0	0
USP32	84669	broad.mit.edu	37	17	58257980	58257980	+	Missense_Mutation	SNP	C	C	T	rs17405746		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr17:58257980C>T	uc002iyo.1	-	33	4853	c.4567G>A	c.(4567-4569)GGT>AGT	p.G1523S	USP32_uc002iyn.1_Missense_Mutation_p.G1193S	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	1523					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			TGGCCCCCACCCAGAATTCCT	0.443		NA											12	22					0	0	0	0
NEDD4L	23327	broad.mit.edu	37	18	55711935	55711935	+	Missense_Mutation	SNP	G	G	A	rs12968145		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr18:55711935G>A	uc002lgy.2	+	1	317	c.43G>A	c.(43-45)GAC>AAC	p.D15N	NEDD4L_uc002lgz.2_Missense_Mutation_p.D15N|NEDD4L_uc002lgx.2_Missense_Mutation_p.D15N|NEDD4L_uc010xee.1_5'Flank|NEDD4L_uc002lha.1_5'Flank	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally	15	C2.				cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4						ACTTTCCGAAGACGAGGTGAG	0.741		NA											5	23					0	0	0	0
ZNF461	92283	broad.mit.edu	37	19	37130912	37130912	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr19:37130912G>T	uc002oem.2	-	6	563	c.335C>A	c.(334-336)TCT>TAT	p.S112Y	ZNF461_uc002oen.2_Missense_Mutation_p.S81Y|ZNF461_uc010xtj.1_Missense_Mutation_p.S89Y	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	112					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CCTTTTTGGAGATAACTTCTG	0.348		NA											12	85					2.27e-07	2.42e-07	1	0
SNRPA	6626	broad.mit.edu	37	19	41268965	41268965	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr19:41268965C>T	uc002ooz.2	+	4	1121	c.586C>T	c.(586-588)CCC>TCC	p.P196S	SNRPA_uc002opa.2_Missense_Mutation_p.P146S	NM_004596	NP_004587	P09012	SNRPA_HUMAN	small nuclear ribonucleoprotein polypeptide A	196	Pro-rich.					nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding			skin(2)|ovary(1)|central_nervous_system(1)	4			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			AGGACAGATGCCCCCTGCCCA	0.607		NA											12	42					0	0	0	0
GRIK5	2901	broad.mit.edu	37	19	42563637	42563637	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr19:42563637G>C	uc002osj.1	-	5	586	c.551C>G	c.(550-552)TCC>TGC	p.S184C	GRIK5_uc010eib.1_Missense_Mutation_p.S103C	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	184	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	CGTCTCCTTGGAGATGAGGAA	0.607		NA											13	68					0	0	0	0
MARK4	57787	broad.mit.edu	37	19	45774927	45774927	+	Silent	SNP	C	C	T	rs140158030		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr19:45774927C>T	uc002pbb.1	+	8	752	c.747C>T	c.(745-747)CTC>CTT	p.L249L	MARK4_uc002paz.1_Missense_Mutation_p.S60L|MARK4_uc002pba.1_Silent_p.L249L|MARK4_uc002pbc.1_Silent_p.L115L			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	249	Protein kinase.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TGTACACCCTCGTCAGCGGCT	0.672		NA											68	42					0	0	0	0
ZNF347	84671	broad.mit.edu	37	19	53643919	53643919	+	Missense_Mutation	SNP	C	C	A	rs150489253	byFrequency	TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr19:53643919C>A	uc002qbb.1	-	5	2231	c.2162G>T	c.(2161-2163)CGT>CTT	p.R721L	ZNF347_uc010eql.1_Missense_Mutation_p.R722L|ZNF347_uc002qbc.1_Missense_Mutation_p.R722L	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	721	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		TAGGCTTGAACGGACACTAAA	0.423		NA											41	168					4.16e-14	4.7e-14	1	0
EPN1	29924	broad.mit.edu	37	19	56203254	56203254	+	Silent	SNP	C	C	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr19:56203254C>T	uc002qlw.2	+	7	1239	c.897C>T	c.(895-897)CCC>CCT	p.P299P	EPN1_uc002qlv.2_Silent_p.P274P|EPN1_uc010etd.2_Silent_p.P299P|EPN1_uc002qlx.2_Silent_p.P385P	NM_001130072	NP_001123544	Q9Y6I3	EPN1_HUMAN	epsin 1 isoform b	299	Ala/Gly/Pro-rich.|8 X 3 AA repeats of [ED]-P-W.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding				0		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		GGGGCGGCCCCCCTGTCCCTC	0.756		NA											9	29					0	0	0	0
AURKC	6795	broad.mit.edu	37	19	57743501	57743501	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr19:57743501G>A	uc002qoe.2	+	3	394	c.205G>A	c.(205-207)GTG>ATG	p.V69M	AURKC_uc002qoc.2_Missense_Mutation_p.V50M|AURKC_uc002qod.2_Missense_Mutation_p.V35M|AURKC_uc010etv.2_Missense_Mutation_p.V66M	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	69	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		CCATTTCATTGTGGCCCTGAA	0.542		NA											34	30					0	0	0	0
NBAS	51594	broad.mit.edu	37	2	15557650	15557650	+	Splice_Site	SNP	C	C	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr2:15557650C>A	uc002rcc.1	-	24	2789	c.2763_splice	c.e24+1	p.S921_splice	NBAS_uc010exl.1_Intron|NBAS_uc002rcd.1_Splice_Site	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein											ovary(2)|liver(1)|skin(1)	4						ATAAAACCTACACTATTCATC	0.323		NA											13	20					0.000219431	0.00022769	1	0
HK2	3099	broad.mit.edu	37	2	75116479	75116479	+	Missense_Mutation	SNP	G	G	A	rs148653106		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr2:75116479G>A	uc002snd.2	+	17	4409	c.2483G>A	c.(2482-2484)CGG>CAG	p.R828Q		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	828	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						GTGGTGGCCCGGCGGGCAGCC	0.607		NA											10	17					0	0	0	0
NFE2L2	4780	broad.mit.edu	37	2	178098956	178098956	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr2:178098956A>T	uc002ulh.3	-	2	644	c.89T>A	c.(88-90)CTT>CAT	p.L30H	NFE2L2_uc002ulg.3_Missense_Mutation_p.L14H|NFE2L2_uc010zfa.1_Missense_Mutation_p.L14H|NFE2L2_uc002uli.3_Missense_Mutation_p.L14H|NFE2L2_uc010fra.2_Missense_Mutation_p.L14H|NFE2L2_uc010frb.2_Missense_Mutation_p.L14H	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	30					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			ACTTACTCCAAGATCTATATC	0.363		NA	Mis		NSCLC|HNSCC					HNSCC(56;0.16)			19	15					0	0	0	0
CASP8	841	broad.mit.edu	37	2	202131240	202131240	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr2:202131240G>A	uc002uxr.1	+	3	240	c.31G>A	c.(31-33)GGG>AGG	p.G11R	CASP8_uc010ftc.1_Missense_Mutation_p.G11R|CASP8_uc002uxo.1_Missense_Mutation_p.G11R|CASP8_uc002uxp.1_Missense_Mutation_p.G11R|CASP8_uc002uxq.1_Missense_Mutation_p.G11R|CASP8_uc002uxs.1_Missense_Mutation_p.G11R|CASP8_uc002uxt.1_Missense_Mutation_p.G70R|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Missense_Mutation_p.G11R|CASP8_uc002uxw.1_Missense_Mutation_p.G11R|CASP8_uc002uxy.1_Missense_Mutation_p.G11R|CASP8_uc002uxx.1_Missense_Mutation_p.G11R|CASP8_uc010ftf.2_Missense_Mutation_p.G11R	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	11	DED 1.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding	p.G11R(1)		upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						TTATGATATTGGGGAACAACT	0.403		NA								HNSCC(4;0.00038)			33	17					0	0	0	0
MPP4	58538	broad.mit.edu	37	2	202509991	202509991	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr2:202509991T>A	uc002uyk.3	-	22	2064	c.1856A>T	c.(1855-1857)CAG>CTG	p.Q619L	ALS2CR4_uc002uyg.1_5'Flank|ALS2CR4_uc002uyh.1_5'Flank|MPP4_uc002uyi.3_Missense_Mutation_p.Q237L|MPP4_uc010ftj.2_Missense_Mutation_p.Q612L|MPP4_uc010zhq.1_Missense_Mutation_p.Q588L|MPP4_uc010zhr.1_Missense_Mutation_p.Q595L|MPP4_uc010zhs.1_Missense_Mutation_p.Q544L|MPP4_uc002uyj.3_Missense_Mutation_p.Q584L|MPP4_uc010zht.1_Missense_Mutation_p.Q561L|MPP4_uc002uyl.3_RNA|MPP4_uc010ftk.2_Missense_Mutation_p.Q575L	NM_033066	NP_149055	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4	619	Potential.					cytoplasm	protein binding				0						AGGCTCCTCCTGAGCCTTCTG	0.443		NA											20	8					0	0	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3684688	3684688	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr20:3684688G>A	uc002wja.2	-	4	757	c.757C>T	c.(757-759)CTT>TTT	p.L253F	SIGLEC1_uc002wiz.3_Missense_Mutation_p.L253F|SIGLEC1_uc002wjc.2_Missense_Mutation_p.L164F	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	253	Ig-like C2-type 2.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						TCACCTGGAAGGATGTTCCTC	0.577		NA											18	38					0	0	0	0
CDS2	8760	broad.mit.edu	37	20	5169814	5169814	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr20:5169814A>C	uc002wls.2	+	11	1340	c.1083A>C	c.(1081-1083)AAA>AAC	p.K361N	CDS2_uc010zqt.1_RNA|CDS2_uc002wlu.2_Missense_Mutation_p.N313T|CDS2_uc010zqu.1_Missense_Mutation_p.K241N|CDS2_uc002wlv.2_Missense_Mutation_p.K263N|CDS2_uc010zqv.1_Missense_Mutation_p.K131N	NM_003818	NP_003809	O95674	CDS2_HUMAN	phosphatidate cytidylyltransferase 2	361					phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphatidate cytidylyltransferase activity				0						GTGGATTCAAACGAGCCTTTA	0.517		NA											23	41					0	0	0	0
PYGB	5834	broad.mit.edu	37	20	25239873	25239873	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr20:25239873C>T	uc002wup.2	+	2	353	c.244C>T	c.(244-246)CGC>TGC	p.R82C		NM_002862	NP_002853	P11216	PYGB_HUMAN	brain glycogen phosphorylase	82					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					Pyridoxal Phosphate(DB00114)	GCTTCCTCAGCGCATTTATTA	0.478		NA											10	27					0	0	0	0
DNTTIP1	116092	broad.mit.edu	37	20	44439538	44439538	+	Silent	SNP	C	C	T	rs148278422		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr20:44439538C>T	uc002xpk.2	+	12	878	c.810C>T	c.(808-810)ATC>ATT	p.I270I	UBE2C_uc002xpl.2_5'Flank|UBE2C_uc002xpm.2_5'Flank|UBE2C_uc002xpn.2_5'Flank|UBE2C_uc002xpo.2_5'Flank|UBE2C_uc002xpp.2_5'Flank|UBE2C_uc002xpq.2_5'Flank	NM_052951	NP_443183	Q9H147	TDIF1_HUMAN	terminal deoxynucleotidyltransferase interacting	270						nucleus				ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.0122)				ACCTCCTCATCGAGGAGGACA	0.507		NA											14	28					0	0	0	0
TIAM1	7074	broad.mit.edu	37	21	32639127	32639127	+	Silent	SNP	C	C	G			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr21:32639127C>G	uc002yow.1	-	5	634	c.162G>C	c.(160-162)GTG>GTC	p.V54V	TIAM1_uc011adk.1_Silent_p.V54V|TIAM1_uc011adl.1_Silent_p.V54V|TIAM1_uc002yox.1_Intron	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	54					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						ATCGGGTGCTCACTTCGGAGT	0.637		NA											10	31					0	0	0	0
TIAM1	7074	broad.mit.edu	37	21	32639148	32639148	+	Silent	SNP	C	C	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr21:32639148C>T	uc002yow.1	-	5	613	c.141G>A	c.(139-141)GTG>GTA	p.V47V	TIAM1_uc011adk.1_Silent_p.V47V|TIAM1_uc011adl.1_Silent_p.V47V|TIAM1_uc002yox.1_Intron	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	47					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TCCTGTGGATCACCTTCCCCG	0.627		NA											7	30					0	0	0	0
TTC3	7267	broad.mit.edu	37	21	38538338	38538338	+	Silent	SNP	C	C	G			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr21:38538338C>G	uc002yvz.2	+	33	3927	c.3822C>G	c.(3820-3822)GTC>GTG	p.V1274V	TTC3_uc011aee.1_Silent_p.V964V|TTC3_uc002ywa.2_Silent_p.V1274V|TTC3_uc002ywb.2_Silent_p.V1274V|TTC3_uc010gnf.2_Silent_p.V1039V|TTC3_uc002ywc.2_Silent_p.V964V|TTC3_uc002ywd.1_Silent_p.V338V	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1274					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				CCAAAGGGGTCTCTTCTAATT	0.458		NA											30	53					0	0	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072531	17072531	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr22:17072531G>A	uc002zlp.1	-	1	1170	c.910C>T	c.(910-912)CTC>TTC	p.L304F		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	304					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GCCAGTGTGAGGGTCTCCTCG	0.512		NA											53	81					0	0	0	0
SEC14L4	284904	broad.mit.edu	37	22	30891410	30891410	+	Missense_Mutation	SNP	G	G	A	rs145663781	byFrequency	TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr22:30891410G>A	uc003aid.2	-	5	354	c.254C>T	c.(253-255)TCG>TTG	p.S85L	SEC14L4_uc011akz.1_Missense_Mutation_p.S85L|SEC14L4_uc003aie.2_Missense_Mutation_p.S70L|SEC14L4_uc003aif.2_Missense_Mutation_p.S31L	NM_174977	NP_777637	Q9UDX3	S14L4_HUMAN	SEC14p-like protein TAP3 isoform a	85	CRAL-TRIO.					integral to membrane|intracellular	lipid binding|transporter activity			skin(1)	1					Vitamin E(DB00163)	AAGACCACCCGAGTCATACAG	0.582		NA											25	44					0	0	0	0
C22orf9	23313	broad.mit.edu	37	22	45607844	45607844	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr22:45607844C>T	uc003bfx.1	-	2	275	c.209G>A	c.(208-210)GGG>GAG	p.G70E	C22orf9_uc003bfv.1_Missense_Mutation_p.G79E|C22orf9_uc003bfw.1_Missense_Mutation_p.G75E|C22orf9_uc010gzx.2_Missense_Mutation_p.G52E	NM_001009880	NP_001009880	Q6ICG6	K0930_HUMAN	hypothetical protein LOC23313 isoform b	70							protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|READ - Rectum adenocarcinoma(1;0.000617)|Colorectal(1;0.0024)		CACCTTCCTCCCGTCTGCACC	0.617		NA											37	74					0	0	0	0
SETD2	29072	broad.mit.edu	37	3	47163754	47163754	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr3:47163754G>C	uc003cqs.2	-	3	2425	c.2372C>G	c.(2371-2373)TCA>TGA	p.S791*	SETD2_uc003cqv.2_Nonsense_Mutation_p.S780*	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	791					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		GTATATGTCTGAATCTTTGGT	0.358		NA	N|F|S|Mis		clear cell renal carcinoma								24	47					0	0	0	0
NPHP3	27031	broad.mit.edu	37	3	132423041	132423041	+	Splice_Site	SNP	C	C	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr3:132423041C>T	uc003epe.1	-	9	1601	c.1524_splice	c.e9+1	p.K508_splice	NPHP3_uc003epf.1_Splice_Site_p.K263_splice	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3						maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						CAAGCACTTACTTTCTCAAAT	0.343		NA											37	66					0	0	0	0
FNDC3B	64778	broad.mit.edu	37	3	172003763	172003763	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr3:172003763G>A	uc003fhy.2	+	7	1010	c.838G>A	c.(838-840)GAG>AAG	p.E280K	FNDC3B_uc003fhz.3_Missense_Mutation_p.E280K|FNDC3B_uc003fia.2_Missense_Mutation_p.E211K	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	280	Fibronectin type-III 1.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		TTCGGGAATAGAGAAACCACA	0.353		NA											15	38					0	0	0	0
UGT2B10	7365	broad.mit.edu	37	4	69696413	69696413	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr4:69696413G>A	uc003hee.2	+	6	1428	c.1403G>A	c.(1402-1404)CGC>CAC	p.R468H	UGT2B10_uc011cam.1_Missense_Mutation_p.R384H	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	468					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						TTTGTCATGCGCCACAAAGGA	0.448		NA											39	60					0	0	0	0
KLKB1	3818	broad.mit.edu	37	4	187171481	187171481	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr4:187171481G>A	uc003iyy.2	+	7	754	c.683G>A	c.(682-684)CGG>CAG	p.R228Q	KLKB1_uc011clc.1_Missense_Mutation_p.G16R|KLKB1_uc011cld.1_Missense_Mutation_p.R190Q	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	228	Apple 3.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		TTTGTGTGTCGGACCATCTGC	0.463		NA											26	67					0	0	0	0
UGT3A1	133688	broad.mit.edu	37	5	35955843	35955843	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr5:35955843C>T	uc003jjv.1	-	6	1356	c.1199G>A	c.(1198-1200)CGA>CAA	p.R400Q	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.R400Q|UGT3A1_uc011cor.1_Missense_Mutation_p.R366Q	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	400	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGCTACTACTCGGACCATGTT	0.483		NA											23	50					0	0	0	0
HCN1	348980	broad.mit.edu	37	5	45262411	45262411	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr5:45262411G>A	uc003jok.2	-	8	2310	c.2285C>T	c.(2284-2286)ACG>ATG	p.T762M		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	762	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						ATTTTTCGGCGTGGAGCTGCC	0.438		NA											12	29					0	0	0	0
RAD17	5884	broad.mit.edu	37	5	68682287	68682287	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr5:68682287A>G	uc003jwo.2	+	8	984	c.922A>G	c.(922-924)AAC>GAC	p.N308D	RAD17_uc003jwg.2_Missense_Mutation_p.N297D|RAD17_uc003jwh.2_Missense_Mutation_p.N297D|RAD17_uc003jwi.2_Missense_Mutation_p.N297D|RAD17_uc003jwj.2_Missense_Mutation_p.N297D|RAD17_uc003jwk.2_Missense_Mutation_p.N297D|RAD17_uc003jwl.2_Missense_Mutation_p.N297D|RAD17_uc003jwm.2_Missense_Mutation_p.N132D|RAD17_uc003jwn.2_Missense_Mutation_p.N211D	NM_133339	NP_579917	O75943	RAD17_HUMAN	RAD17 homolog isoform 2	308					cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		TATAGAAGCTAACAAGGTAAG	0.284		NA						Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					8	16					0	0	0	0
IQGAP2	10788	broad.mit.edu	37	5	75991296	75991296	+	Silent	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr5:75991296G>A	uc003kek.2	+	32	4233	c.4011G>A	c.(4009-4011)ACG>ACA	p.T1337T	IQGAP2_uc011csv.1_Silent_p.T833T|IQGAP2_uc003kel.2_Silent_p.T833T|IQGAP2_uc010izw.1_Silent_p.T38T	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1337					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		ACCATGCCACGGACATGGTGA	0.433		NA											12	27					0	0	0	0
ARRDC3	57561	broad.mit.edu	37	5	90670932	90670932	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr5:90670932G>A	uc003kjz.2	-	5	917	c.677C>T	c.(676-678)GCA>GTA	p.A226V		NM_020801	NP_065852	Q96B67	ARRD3_HUMAN	arrestin domain containing 3	226					signal transduction	cytoplasm	protein binding			ovary(1)|breast(1)	2		all_cancers(142;2.22e-05)|all_epithelial(76;1.58e-07)|all_lung(232;0.000521)|Lung NSC(167;0.000548)|Ovarian(174;0.0798)|Colorectal(57;0.207)		OV - Ovarian serous cystadenocarcinoma(54;4.56e-30)|Epithelial(54;7.55e-26)|all cancers(79;3.63e-22)		GTAAATGGCTGCCTTTGGCAC	0.418		NA											20	38					0	0	0	0
NDST1	3340	broad.mit.edu	37	5	149901143	149901143	+	Silent	SNP	C	C	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr5:149901143C>T	uc003lsk.3	+	2	829	c.327C>T	c.(325-327)TTC>TTT	p.F109F	NDST1_uc011dcj.1_Silent_p.F109F|NDST1_uc003lsl.2_Silent_p.F109F	NM_001543	NP_001534	P52848	NDST1_HUMAN	N-deacetylase/N-sulfotransferase (heparan	109	Heparan sulfate N-deacetylase 1.|Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(1)|skin(1)	2		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCAGCCGCTTCAAATACCGCA	0.612		NA											25	80					0	0	0	0
GRIA1	2890	broad.mit.edu	37	5	153149755	153149755	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr5:153149755A>T	uc003lva.3	+	13	2415	c.2050A>T	c.(2050-2052)ATG>TTG	p.M684L	GRIA1_uc003luy.3_Missense_Mutation_p.M684L|GRIA1_uc003luz.3_Missense_Mutation_p.M589L|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.M604L|GRIA1_uc011dcx.1_Missense_Mutation_p.M615L|GRIA1_uc011dcy.1_Missense_Mutation_p.M694L|GRIA1_uc011dcz.1_Missense_Mutation_p.M694L	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	684	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GTTTGAGAAGATGTGGACATA	0.463		NA											33	62					0	0	0	0
SNRNP48	154007	broad.mit.edu	37	6	7601664	7601664	+	Missense_Mutation	SNP	G	G	A	rs141422613		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr6:7601664G>A	uc003mxr.2	+	5	561	c.502G>A	c.(502-504)GTA>ATA	p.V168I	SNRNP48_uc003mxs.2_RNA	NM_152551	NP_689764	Q6IEG0	SNR48_HUMAN	U11/U12 snRNP 48K	168					mRNA processing	cytoplasm|U12-type spliceosomal complex	metal ion binding				0						CTATGATTTCGTAGTTGAGGA	0.378		NA											23	32					0	0	0	0
HLA-DQA2	3118	broad.mit.edu	37	6	32714066	32714066	+	Silent	SNP	C	C	T	rs143176293		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr6:32714066C>T	uc003obx.2	+	4	721	c.663C>T	c.(661-663)TGC>TGT	p.C221C		NM_020056	NP_064440	P01906	DQA2_HUMAN	major histocompatibility complex, class II, DQ	221	Helical; (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTTTGGTCTGCGCCCTGGGGT	0.552		NA											28	57					0	0	0	0
ZNF318	24149	broad.mit.edu	37	6	43306213	43306213	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr6:43306213C>A	uc003oux.2	-	10	5601	c.5523G>T	c.(5521-5523)TTG>TTT	p.L1841F	ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1841					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			TTCCTGTCATCAATTTATTGG	0.378		NA											28	39					2.49e-11	2.78e-11	1	0
C6orf138	442213	broad.mit.edu	37	6	47846396	47846396	+	Silent	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr6:47846396G>A	uc011dwm.1	-	3	2218	c.2133C>T	c.(2131-2133)CAC>CAT	p.H711H	C6orf138_uc011dwn.1_Silent_p.H475H	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	728	Helical; (Potential).					integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						GTGGTGCACAGTGGTCAATGG	0.438		NA											8	11					0	0	0	0
DOPEY1	23033	broad.mit.edu	37	6	83845504	83845504	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr6:83845504C>T	uc003pjs.1	+	20	3297	c.3037C>T	c.(3037-3039)CGT>TGT	p.R1013C	DOPEY1_uc011dyy.1_Missense_Mutation_p.R1004C|DOPEY1_uc010kbl.1_Missense_Mutation_p.R1004C|DOPEY1_uc003pjt.2_5'Flank	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	1013					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TTCAGTACAGCGTGTACAAGC	0.433		NA											40	62					0	0	0	0
LATS1	9113	broad.mit.edu	37	6	150005729	150005729	+	Splice_Site	SNP	C	C	T	rs34361382		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr6:150005729C>T	uc003qmu.1	-	4	1045	c.497_splice	c.e4-1	p.G166_splice	LATS1_uc010kif.1_Splice_Site_p.G61_splice|LATS1_uc003qmv.1_Splice_Site_p.G166_splice|LATS1_uc003qmw.2_Intron|LATS1_uc010kig.1_Intron	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1						cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		TGCACATTCCCTATGGTTATA	0.383		NA											18	33					0	0	0	0
C7orf57	136288	broad.mit.edu	37	7	48080963	48080963	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr7:48080963G>A	uc003toh.3	+	3	300	c.88G>A	c.(88-90)GAG>AAG	p.E30K	C7orf57_uc003toi.3_5'UTR	NM_001100159	NP_001093629	Q8NEG2	CG057_HUMAN	hypothetical protein LOC136288	30										ovary(1)	1						GAAGCGCTCTGAGAAGGCCGT	0.587		NA											9	25					0	0	0	0
GRM3	2913	broad.mit.edu	37	7	86415775	86415775	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr7:86415775G>A	uc003uid.2	+	3	1766	c.667G>A	c.(667-669)GGG>AGG	p.G223R	GRM3_uc010lef.2_Missense_Mutation_p.G221R|GRM3_uc010leg.2_Missense_Mutation_p.G95R|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	223	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GGGTGATTACGGGGAGACAGG	0.612		NA											26	42					0	0	0	0
PTDSS1	9791	broad.mit.edu	37	8	97311963	97311963	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr8:97311963G>A	uc003yht.1	+	6	744	c.642G>A	c.(640-642)TGG>TGA	p.W214*	PTDSS1_uc003yhu.1_Nonsense_Mutation_p.W68*	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	214					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	CCGAGTGCTGGTGGGATCAAG	0.493		NA											47	68					0	0	0	0
FLJ46321	389763	broad.mit.edu	37	9	84609395	84609395	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr9:84609395C>G	uc004amn.2	+	4	4057	c.4010C>G	c.(4009-4011)TCC>TGC	p.S1337C		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1337						integral to membrane					0						AGCAAATCTTCCCCAACCTTG	0.478		NA											5	9					0	0	0	0
FAM47B	170062	broad.mit.edu	37	X	34962352	34962352	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chrX:34962352G>A	uc004ddi.1	+	1	1422	c.1404G>A	c.(1402-1404)TGG>TGA	p.W468*		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	468										ovary(3)|breast(1)	4						ACTTCAAGTGGGCTGGAGACC	0.433		NA											4	45					0	0	0	0
ELF4	2000	broad.mit.edu	37	X	129201147	129201147	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chrX:129201147G>A	uc004evd.3	-	9	1926	c.1541C>T	c.(1540-1542)TCT>TTT	p.S514F	ELF4_uc004eve.3_Missense_Mutation_p.S514F	NM_001421	NP_001412	Q99607	ELF4_HUMAN	E74-like factor 4	514					natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGGGGGCTGAGAGCTGGGCCC	0.642		NA	T	ERG	AML								24	10					0	0	0	0
ITSN2	50618	broad.mit.edu	37	2	24471709	24471710	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr2:24471709_24471710insT	uc002rfe.2	-	26	3420_3421	c.3162_3163insA	c.(3160-3165)AAACCTfs	p.K1054fs	ITSN2_uc002rff.2_Frame_Shift_Ins_p.K1027fs|ITSN2_uc002rfg.2_Frame_Shift_Ins_p.K1054fs|ITSN2_uc002rfh.1_RNA	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	1054_1055	SH3 4.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TACGTACCAGGTTTTTTATTTG	0.342		NA											24	70	---	---	---	---	NA	NA	NA	NA
ELF2	1998	broad.mit.edu	37	4	139980327	139980327	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr4:139980327delT	uc003ihp.1	-	9	1762	c.1556delA	c.(1555-1557)AAGfs	p.K519fs	ELF2_uc003ihm.1_Frame_Shift_Del_p.K471fs|ELF2_uc003ihn.1_Frame_Shift_Del_p.K459fs|ELF2_uc003iho.1_Frame_Shift_Del_p.K442fs|ELF2_uc011chc.1_Frame_Shift_Del_p.K334fs	NM_201999	NP_973728	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription	531					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2	all_hematologic(180;0.162)					CTCTGGCCCCTTTATGACTGC	0.448		NA											63	144	---	---	---	---	NA	NA	NA	NA
HLA-B	3106	broad.mit.edu	37	6	31323136	31323137	+	Frame_Shift_Ins	INS	-	-	ATGG	rs41551415		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr6:31323136_31323137insATGG	uc003nth.2	-	4	906_907	c.852_853insCCAT	c.(850-855)CATGTAfs	p.H284fs	HLA-C_uc003ntb.2_RNA|HLA-C_uc003ntc.1_5'Flank|HLA-B_uc010jsm.1_RNA|HLA-B_uc011dnk.1_RNA|HLA-B_uc003ntf.2_Intron|HLA-B_uc003ntg.1_Frame_Shift_Ins_p.H163fs|HLA-B_uc003nti.1_RNA|HLA-B_uc010jsn.1_RNA	NM_005514	NP_005505	P01889	1B07_HUMAN	major histocompatibility complex, class I, B	284_285	Alpha-3.|Ig-like C1-type.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity				0						TCATGCTGTACATGGCATGTGT	0.564		NA							Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				8	42	---	---	---	---	NA	NA	NA	NA
DST	667	broad.mit.edu	37	6	56496014	56496017	+	Frame_Shift_Del	DEL	TATG	TATG	-			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr6:56496014_56496017delTATG	uc003pdf.2	-	29	4063_4066	c.4035_4038delCATA	c.(4033-4038)TACATAfs	p.Y1345fs	DST_uc003pcz.3_Frame_Shift_Del_p.Y1167fs|DST_uc011dxj.1_Frame_Shift_Del_p.Y1196fs|DST_uc011dxk.1_Frame_Shift_Del_p.Y1207fs|DST_uc003pcy.3_Frame_Shift_Del_p.Y841fs|DST_uc003pdb.2_Frame_Shift_Del_p.Y841fs|DST_uc003pdc.3_Frame_Shift_Del_p.Y841fs|DST_uc003pdd.3_Frame_Shift_Del_p.Y841fs	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	1167_1168					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CATACTTATCTATGTAAGTGGAAG	0.299		NA											15	47	---	---	---	---	NA	NA	NA	NA
DST	667	broad.mit.edu	37	6	56496801	56496802	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr6:56496801_56496802delAG	uc003pdf.2	-	28	3771_3772	c.3743_3744delCT	c.(3742-3744)TCTfs	p.S1248fs	DST_uc003pcz.3_Frame_Shift_Del_p.S1070fs|DST_uc011dxj.1_Frame_Shift_Del_p.S1099fs|DST_uc011dxk.1_Frame_Shift_Del_p.S1110fs|DST_uc003pcy.3_Frame_Shift_Del_p.S744fs|DST_uc003pdb.2_Frame_Shift_Del_p.S744fs|DST_uc003pdc.3_Frame_Shift_Del_p.S744fs|DST_uc003pdd.3_Frame_Shift_Del_p.S744fs	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	1070					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTCGAACTTCAGAGATGTAGAG	0.361		NA											17	37	---	---	---	---	NA	NA	NA	NA
