Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
KLHL17	339451	broad.mit.edu	37	1	896822	896822	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:896822G>A	uc001aca.1	+	2	364	c.257G>A	c.(256-258)CGC>CAC	p.R86H	NOC2L_uc001aby.3_5'Flank|NOC2L_uc001abz.3_5'Flank|NOC2L_uc009vjq.2_5'Flank|NOC2L_uc009vjr.1_5'Flank|KLHL17_uc001acb.1_5'Flank|KLHL17_uc010nya.1_5'Flank|KLHL17_uc001acc.1_5'Flank|KLHL17_uc010nyb.1_5'Flank	NM_198317	NP_938073	Q6TDP4	KLH17_HUMAN	kelch-like 17	86					actin cytoskeleton organization	actin cytoskeleton|cell junction|postsynaptic density|postsynaptic membrane	protein complex scaffold				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.52e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.59e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AGCCGCATGCGCCAGCGCGGC	0.672		NA											5	28					0	0	0	0
SDF4	51150	broad.mit.edu	37	1	1152946	1152946	+	Silent	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:1152946G>A	uc001adh.3	-	7	1364	c.1035C>T	c.(1033-1035)TTC>TTT	p.F345F	SDF4_uc001adg.2_RNA|SDF4_uc001adi.3_3'UTR|SDF4_uc009vjv.2_Silent_p.F223F|SDF4_uc009vjw.2_RNA	NM_016176	NP_057260	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4 isoform 2	345	Necessary for intracellular retention in Golgi apparatus lumen (By similarity).|EF-hand 6.				cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|calcium ion binding|identical protein binding|protein binding			upper_aerodigestive_tract(1)|large_intestine(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		TGCCCGTGAAGAACTCGCTGT	0.537		NA											11	57					0	0	0	0
ACAP3	116983	broad.mit.edu	37	1	1235353	1235353	+	Missense_Mutation	SNP	C	C	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:1235353C>G	uc001aeb.2	-	8	737	c.663G>C	c.(661-663)GAG>GAC	p.E221D	ACAP3_uc001ady.2_5'Flank|ACAP3_uc001aea.2_Missense_Mutation_p.E179D|ACAP3_uc001aec.1_Missense_Mutation_p.E179D	NM_030649	NP_085152	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH	221					filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding				0						AAAGGCTCACCTCGGCTGCCA	0.632		NA											7	22					0	0	0	0
UBE4B	10277	broad.mit.edu	37	1	10211518	10211518	+	Missense_Mutation	SNP	A	A	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:10211518A>T	uc001aqs.3	+	21	3538	c.2825A>T	c.(2824-2826)AAC>ATC	p.N942I	UBE4B_uc001aqr.3_Missense_Mutation_p.N813I|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Missense_Mutation_p.N397I|UBE4B_uc001aqt.1_Missense_Mutation_p.N282I	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	942					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		TTTATGACCAACCCTGCTGTT	0.428		NA											15	100					0	0	0	0
PGD	5226	broad.mit.edu	37	1	10473290	10473290	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:10473290G>A	uc001arc.2	+	8	916	c.826G>A	c.(826-828)GTA>ATA	p.V276I	PGD_uc001ard.2_Missense_Mutation_p.V196I|PGD_uc010oak.1_Missense_Mutation_p.V254I|PGD_uc010oal.1_Missense_Mutation_p.V263I	NM_002631	NP_002622	P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	276					pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			ovary(1)	1	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)		GGAATACGGCGTACCCGTCAC	0.542		NA											17	33					0	0	0	0
NBPF1	55672	broad.mit.edu	37	1	16902828	16902828	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:16902828C>T	uc009vos.1	-	19	2941	c.2053G>A	c.(2053-2055)GAC>AAC	p.D685N	NBPF1_uc009vot.1_Intron|NBPF1_uc001ayz.1_Missense_Mutation_p.D143N|NBPF1_uc010oce.1_Missense_Mutation_p.D414N	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	685						cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTGGAGGTCCTGCCCCTGG	0.577		NA											27	740					0	0	0	0
CAP1	10487	broad.mit.edu	37	1	40525772	40525772	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:40525772C>T	uc001cfa.3	+	3	375	c.146C>T	c.(145-147)TCG>TTG	p.S49L	CAP1_uc010ojd.1_RNA|CAP1_uc001cey.3_Missense_Mutation_p.S49L|CAP1_uc001cez.3_Missense_Mutation_p.S49L|CAP1_uc009vvz.2_Missense_Mutation_p.S49L|CAP1_uc010oje.1_Missense_Mutation_p.R19C	NM_006367	NP_006358	Q01518	CAP1_HUMAN	adenylyl cyclase-associated protein	49					activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			ovary(1)	1	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GCATTTGACTCGCTGCTTGCT	0.463		NA											21	49					0	0	0	0
KIAA0467	23334	broad.mit.edu	37	1	43909378	43909378	+	Silent	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:43909378G>A	uc001cjk.1	+	47	6501	c.6039G>A	c.(6037-6039)CTG>CTA	p.L2013L	KIAA0467_uc001cjl.1_5'Flank	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2912						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGAAGGAGCTGAGCTTGGCTT	0.632		NA											45	153					0	0	0	0
NBPF9	400818	broad.mit.edu	37	1	144618116	144618116	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:144618116G>T	uc009wig.1	+	6	389	c.313G>T	c.(313-315)GAG>TAG	p.E105*	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Intron|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Nonsense_Mutation_p.E36*|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Nonsense_Mutation_p.E36*|NBPF9_uc010oyg.1_Nonsense_Mutation_p.E70*|NBPF9_uc009wii.1_5'UTR	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	105	Potential.					cytoplasm					0						TCAGGAACGAGAGCTGACGCA	0.473		NA											59	472					8.31e-28	1.75e-27	1	0
PRG4	10216	broad.mit.edu	37	1	186275989	186275989	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:186275989G>T	uc001gru.3	+	7	1189	c.1138G>T	c.(1138-1140)GAG>TAG	p.E380*	PRG4_uc001grt.3_Nonsense_Mutation_p.E339*|PRG4_uc009wyl.2_Nonsense_Mutation_p.E287*|PRG4_uc009wym.2_Nonsense_Mutation_p.E246*|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	380	5.|59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CACCCCCAAGGAGCCTGCACC	0.642		NA											22	101					1.11e-12	2.29e-12	1	0
PTPRC	5788	broad.mit.edu	37	1	198719738	198719738	+	Silent	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:198719738C>T	uc001gur.1	+	29	3364	c.3184C>T	c.(3184-3186)CTG>TTG	p.L1062L	PTPRC_uc001gus.1_Silent_p.L1014L|PTPRC_uc001gut.1_Silent_p.L901L	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1062	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						GCTGACAGAACTGAAACATGG	0.408		NA											16	78					0	0	0	0
DDX59	83479	broad.mit.edu	37	1	200635479	200635479	+	Missense_Mutation	SNP	C	C	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:200635479C>A	uc009wzk.2	-	2	633	c.390G>T	c.(388-390)GAG>GAT	p.E130D	DDX59_uc010ppl.1_Missense_Mutation_p.E130D	NM_001031725	NP_001026895	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	130	HIT-type.					intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4						TCGCTTTACACTCCAAACTAC	0.448		NA											20	58					2.38e-13	4.93e-13	1	0
KIF26B	55083	broad.mit.edu	37	1	245775205	245775205	+	Silent	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:245775205C>T	uc001ibf.1	+	9	2465	c.2025C>T	c.(2023-2025)GAC>GAT	p.D675D	KIF26B_uc010pyq.1_Silent_p.D675D|KIF26B_uc001ibg.1_Silent_p.D293D	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	675	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			ATGAGGACGACCACCGCAACT	0.612		NA											6	45					0	0	0	0
PCDH15	65217	broad.mit.edu	37	10	55955493	55955493	+	Missense_Mutation	SNP	T	T	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr10:55955493T>G	uc001jju.1	-	11	1650	c.1255A>C	c.(1255-1257)AAT>CAT	p.N419H	PCDH15_uc010qhq.1_Missense_Mutation_p.N424H|PCDH15_uc010qhr.1_Missense_Mutation_p.N419H|PCDH15_uc010qhs.1_Missense_Mutation_p.N424H|PCDH15_uc010qht.1_Missense_Mutation_p.N419H|PCDH15_uc010qhu.1_Missense_Mutation_p.N419H|PCDH15_uc001jjv.1_Missense_Mutation_p.N397H|PCDH15_uc010qhv.1_Missense_Mutation_p.N419H|PCDH15_uc010qhw.1_Missense_Mutation_p.N382H|PCDH15_uc010qhx.1_Missense_Mutation_p.N419H|PCDH15_uc010qhy.1_Missense_Mutation_p.N424H|PCDH15_uc010qhz.1_Missense_Mutation_p.N419H|PCDH15_uc010qia.1_Missense_Mutation_p.N397H|PCDH15_uc010qib.1_Missense_Mutation_p.N397H|PCDH15_uc001jjw.2_Missense_Mutation_p.N419H	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	419	Cadherin 4.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GAAGTCAAATTGAGACTGTCC	0.368		NA								HNSCC(58;0.16)			14	43					0	0	0	0
TET1	80312	broad.mit.edu	37	10	70333694	70333694	+	Silent	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr10:70333694C>T	uc001jok.3	+	2	2104	c.1599C>T	c.(1597-1599)CTC>CTT	p.L533L		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	533	Sufficient for binding to genomic CpG islands.				DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TAGCCCAACTCTCTCAGGCTG	0.522		NA											11	74					0	0	0	0
KIF20B	9585	broad.mit.edu	37	10	91532579	91532579	+	Silent	SNP	A	A	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr10:91532579A>G	uc001kgs.1	+	32	5448	c.5376A>G	c.(5374-5376)TCA>TCG	p.S1792S	KIF20B_uc001kgr.1_Silent_p.S1752S|KIF20B_uc001kgt.1_Silent_p.S1003S|KIF20B_uc009xtw.1_RNA	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	1792	Interaction with PIN1.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						TTGATATATCAGGCCAAGTGG	0.328		NA											3	88					0	0	0	0
PDCD11	22984	broad.mit.edu	37	10	105179454	105179454	+	Missense_Mutation	SNP	G	G	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr10:105179454G>T	uc001kwy.1	+	16	2353	c.2266G>T	c.(2266-2268)GCC>TCC	p.A756S		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	756	S1 motif 8.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TAGCGGACTGGCCCCAAAAGC	0.488		NA											10	54					4.69e-08	9.62e-08	1	0
PHRF1	57661	broad.mit.edu	37	11	605263	605263	+	Missense_Mutation	SNP	C	C	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr11:605263C>G	uc001lqe.2	+	11	1428	c.1297C>G	c.(1297-1299)CTG>GTG	p.L433V	PHRF1_uc010qwc.1_Missense_Mutation_p.L433V|PHRF1_uc010qwd.1_Missense_Mutation_p.L432V|PHRF1_uc010qwe.1_Missense_Mutation_p.L429V|PHRF1_uc009ybz.1_Missense_Mutation_p.L224V|PHRF1_uc009yca.1_5'Flank	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	433							RNA polymerase binding|zinc ion binding				0						CTCTCTGTCTCTGTTTGGAGA	0.607		NA											38	97					0	0	0	0
BRSK2	9024	broad.mit.edu	37	11	1475777	1475777	+	Missense_Mutation	SNP	T	T	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr11:1475777T>C	uc001lti.2	+	16	1993	c.1607T>C	c.(1606-1608)GTG>GCG	p.V536A	BRSK2_uc009ycv.1_Missense_Mutation_p.V558A|BRSK2_uc001lth.1_Missense_Mutation_p.V536A|BRSK2_uc001ltj.2_Missense_Mutation_p.V536A|BRSK2_uc001ltk.2_RNA|BRSK2_uc001ltl.2_Missense_Mutation_p.V536A|BRSK2_uc001ltm.2_Missense_Mutation_p.V582A|BRSK2_uc001ltn.2_RNA|BRSK2_uc010qwx.1_RNA|BRSK2_uc009ycw.2_Missense_Mutation_p.V32A	NM_003957	NP_003948	Q8IWQ3	BRSK2_HUMAN	BR serine/threonine kinase 2	536					establishment of cell polarity|neuron differentiation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0		all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00144)|Lung(200;0.0713)|LUSC - Lung squamous cell carcinoma(625;0.0842)		CAGATCTTCGTGGTCATCAAA	0.602		NA											12	41					0	0	0	0
IPO7	10527	broad.mit.edu	37	11	9435863	9435863	+	Silent	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr11:9435863C>T	uc001mho.2	+	5	683	c.541C>T	c.(541-543)CTA>TTA	p.L181L		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	181					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TCTGCCAGTTCTAAAGGATCG	0.388		NA											20	60					0	0	0	0
MRGPRX3	117195	broad.mit.edu	37	11	18159571	18159571	+	Silent	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr11:18159571C>T	uc001mnu.2	+	3	1183	c.822C>T	c.(820-822)TTC>TTT	p.F274F		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	274	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						TTTACTTCTTCGTGGGCTCCT	0.512		NA											30	89					0	0	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735369	55735369	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr11:55735369G>A	uc010rit.1	-	1	571	c.571C>T	c.(571-573)CAT>TAT	p.H191Y		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	191	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					GCTACTACATGGACTGTTATC	0.398		NA											9	36					0	0	0	0
TCIRG1	10312	broad.mit.edu	37	11	67817516	67817516	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr11:67817516G>A	uc001one.2	+	17	2209	c.2101G>A	c.(2101-2103)GAT>AAT	p.D701N	TCIRG1_uc001ong.2_Missense_Mutation_p.D485N|TCIRG1_uc001onh.2_Missense_Mutation_p.D403N|TCIRG1_uc001oni.2_Missense_Mutation_p.D205N|TCIRG1_uc009ysd.2_RNA	NM_006019	NP_006010	Q13488	VPP3_HUMAN	T-cell, immune regulator 1 isoform a	701	Lumenal (Potential).				ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			ovary(1)	1						GGGCCTGGATGATGAAGAGGA	0.672		NA											10	27					0	0	0	0
GDPD5	81544	broad.mit.edu	37	11	75152748	75152748	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr11:75152748C>T	uc001owo.3	-	14	1805	c.1268G>A	c.(1267-1269)AGA>AAA	p.R423K	GDPD5_uc001owp.3_Missense_Mutation_p.R423K|GDPD5_uc001own.3_Missense_Mutation_p.R178K|GDPD5_uc009yuc.2_Missense_Mutation_p.R285K|GDPD5_uc009yud.2_Missense_Mutation_p.R304K	NM_030792	NP_110419	Q8WTR4	GDPD5_HUMAN	glycerophosphodiester phosphodiesterase domain	423	Extracellular (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process|nervous system development	endomembrane system|growth cone|integral to membrane|perinuclear region of cytoplasm	glycerophosphodiester phosphodiesterase activity			ovary(1)	1						GATGTGGCCTCTCCGCAGGCT	0.672		NA											6	13					0	0	0	0
ATM	472	broad.mit.edu	37	11	108236053	108236053	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr11:108236053G>A	uc001pkb.1	+	63	9374	c.8989G>A	c.(8989-8991)GAT>AAT	p.D2997N	ATM_uc009yxr.1_Missense_Mutation_p.D2997N|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.D1649N	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2997					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TGTCCTTAGTGATATTGACCA	0.398		NA	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			22	33					0	0	0	0
CCDC15	80071	broad.mit.edu	37	11	124908467	124908467	+	Missense_Mutation	SNP	G	G	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr11:124908467G>C	uc001qbm.3	+	14	2811	c.2552G>C	c.(2551-2553)AGA>ACA	p.R851T		NM_025004	NP_079280	Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	851	Potential.					centrosome				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		AAAGGAACCAGAGAAAAACAA	0.358		NA											5	1					0	0	0	0
RAD51AP1	10635	broad.mit.edu	37	12	4657916	4657916	+	Missense_Mutation	SNP	C	C	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:4657916C>G	uc001qmw.2	+	7	677	c.521C>G	c.(520-522)TCT>TGT	p.S174C	RAD51AP1_uc001qmu.2_Missense_Mutation_p.S157C|RAD51AP1_uc001qmv.2_Missense_Mutation_p.S120C|RAD51AP1_uc010sep.1_Missense_Mutation_p.S39C|RAD51AP1_uc010seq.1_Missense_Mutation_p.S39C|RAD51AP1_uc009zeg.2_5'Flank	NM_001130862	NP_001124334	Q96B01	R51A1_HUMAN	RAD51 associated protein 1 isoform a	174					double-strand break repair via homologous recombination		double-stranded DNA binding|protein binding|protein binding|RNA binding|single-stranded DNA binding				0			Colorectal(7;0.00306)|COAD - Colon adenocarcinoma(12;0.0389)			AAAGCAGCATCTAAAGCTGCA	0.413		NA											22	68					0	0	0	0
ANO2	57101	broad.mit.edu	37	12	5744499	5744499	+	Silent	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:5744499G>A	uc001qnm.2	-	17	1707	c.1635C>T	c.(1633-1635)TTC>TTT	p.F545F		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	550	Helical; (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						AGACGATTGAGAATGTCAGGG	0.478		NA											10	16					0	0	0	0
CLSTN3	9746	broad.mit.edu	37	12	7303242	7303242	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:7303242C>T	uc001qsr.2	+	15	2626	c.2348C>T	c.(2347-2349)TCG>TTG	p.S783L	CLSTN3_uc001qss.2_Missense_Mutation_p.S795L	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	783	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						CTTTCCTGCTCGGAAATGAAT	0.547		NA											44	105					0	0	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20893267	20893267	+	Silent	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:20893267C>T	uc001rej.3	+	13	2053	c.1698C>T	c.(1696-1698)TCC>TCT	p.S566S	SLCO1C1_uc010sii.1_Silent_p.S566S|SLCO1C1_uc010sij.1_Silent_p.S517S|SLCO1C1_uc009zip.2_Silent_p.S400S|SLCO1C1_uc001rei.2_Silent_p.S566S|SLCO1C1_uc010sik.1_Silent_p.S448S	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	566	Helical; Name=10; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					ATACTTTATCCCTAGGTGGCA	0.378		NA											31	93					0	0	0	0
DIP2B	57609	broad.mit.edu	37	12	51080375	51080375	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:51080375G>A	uc001rwv.2	+	12	1617	c.1461G>A	c.(1459-1461)TGG>TGA	p.W487*	DIP2B_uc009zlt.2_5'UTR	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	487						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						GGCTCAAATGGGTTGTAACAG	0.448		NA											17	22					0	0	0	0
CS	1431	broad.mit.edu	37	12	56669923	56669923	+	Missense_Mutation	SNP	C	C	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:56669923C>G	uc001sks.1	-	7	835	c.645G>C	c.(643-645)AAG>AAC	p.K215N	CS_uc010sql.1_Missense_Mutation_p.K202N|CS_uc001skr.1_Missense_Mutation_p.K149N|CS_uc001skt.1_Missense_Mutation_p.K170N|CS_uc010sqm.1_Missense_Mutation_p.K149N	NM_004077	NP_004068	O75390	CISY_HUMAN	citrate synthase precursor	215					cellular carbohydrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	citrate (Si)-synthase activity				0		Myeloproliferative disorder(1001;0.000374)		BRCA - Breast invasive adenocarcinoma(357;6.17e-07)		TTCGGTAGATCTTTGCTGCAA	0.418		NA											21	30					0	0	0	0
LRP1	4035	broad.mit.edu	37	12	57548365	57548365	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:57548365C>T	uc001snd.2	+	8	1574	c.1108C>T	c.(1108-1110)CAT>TAT	p.H370Y	LRP1_uc001snc.1_Missense_Mutation_p.H370Y	NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	370	LDL-receptor class B 2.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGTGTTTCCTCATGGCATCAC	0.547		NA											9	10					0	0	0	0
CLIP1	6249	broad.mit.edu	37	12	122812709	122812709	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:122812709C>T	uc001ucg.1	-	16	3140	c.3034G>A	c.(3034-3036)GAA>AAA	p.E1012K	CLIP1_uc001uch.1_Missense_Mutation_p.E1001K|CLIP1_uc001uci.1_Missense_Mutation_p.E966K|CLIP1_uc001ucj.1_Missense_Mutation_p.E587K	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	1012	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		ATTTTCTTTTCCTGCAGAGAC	0.493		NA											17	155					0	0	0	0
SFRS8	6433	broad.mit.edu	37	12	132239043	132239043	+	Missense_Mutation	SNP	A	A	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:132239043A>G	uc001uja.1	+	9	1593	c.1453A>G	c.(1453-1455)AGA>GGA	p.R485G	SFRS8_uc010tbn.1_Missense_Mutation_p.R485G|SFRS8_uc001ujb.1_Missense_Mutation_p.R278G|SFRS8_uc001uiz.1_3'UTR	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	485	SURP motif 2.				mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		GAATGATCAAAGGTCAGAAGA	0.433		NA											23	30					0	0	0	0
PUS1	80324	broad.mit.edu	37	12	132414283	132414283	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:132414283C>T	uc001ujf.2	+	1	495	c.16C>T	c.(16-18)CGC>TGC	p.R6C	PUS1_uc001ujg.2_Intron|PUS1_uc001ujh.2_Intron|PUS1_uc001uji.2_5'Flank	NM_025215	NP_079491	Q9Y606	TRUA_HUMAN	pseudouridine synthase 1 isoform 1	6						mitochondrion	pseudouridine synthase activity|pseudouridylate synthase activity|RNA binding			breast(1)|central_nervous_system(1)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.05e-08)|Epithelial(86;2.51e-07)|all cancers(50;2.94e-07)		CCTCCAGCTTCGCGCGCTGTT	0.726		NA											13	15					0	0	0	0
IFT88	8100	broad.mit.edu	37	13	21217595	21217595	+	Missense_Mutation	SNP	T	T	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr13:21217595T>G	uc001unh.2	+	21	2107	c.1711T>G	c.(1711-1713)TAT>GAT	p.Y571D	IFT88_uc001uni.2_Missense_Mutation_p.Y562D|IFT88_uc001unj.2_Missense_Mutation_p.Y561D|IFT88_uc010tcq.1_Missense_Mutation_p.Y542D	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	571	TPR 9.				cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		TTGCATAAGATATGAATTAAT	0.323		NA											20	16					0	0	0	0
PHF11	51131	broad.mit.edu	37	13	50100528	50100528	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr13:50100528G>T	uc001vdb.2	+	9	1112	c.775G>T	c.(775-777)GAA>TAA	p.E259*	PHF11_uc001vdc.2_Nonsense_Mutation_p.E220*|PHF11_uc001vdd.2_RNA	NM_001040443	NP_001035533	Q9UIL8	PHF11_HUMAN	PHD finger protein 11 isoform a	259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding				0		Lung NSC(96;2.1e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.38e-09)		TCCAGACTATGAAGAAATCGG	0.353		NA											3	10					0.004672	0.00911403	1	0
SEC23A	10484	broad.mit.edu	37	14	39565170	39565170	+	Silent	SNP	T	T	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr14:39565170T>C	uc001wup.1	-	2	376	c.153A>G	c.(151-153)TTA>TTG	p.L51L	SEC23A_uc010tqa.1_Intron|SEC23A_uc010tqb.1_Silent_p.L51L	NM_006364	NP_006355	Q15436	SC23A_HUMAN	SEC23-related protein A	51					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		GAATAGGTGGTAAGTCAGGTC	0.413		NA											14	50					0	0	0	0
FCF1	51077	broad.mit.edu	37	14	75199488	75199488	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr14:75199488T>A	uc001xqh.2	+	6	471	c.420T>A	c.(418-420)TAT>TAA	p.Y140*	FCF1_uc001xqf.1_Nonsense_Mutation_p.Y125*|FCF1_uc001xqg.2_RNA|FCF1_uc001xqi.2_RNA	NM_015962	NP_057046	Q9Y324	FCF1_HUMAN	FCF1 small subunit	140	PINc.				rRNA processing	nucleolus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0037)		AAGGAACCTATGCAGATGACT	0.343		NA											6	76					0	0	0	0
ADSSL1	122622	broad.mit.edu	37	14	105207565	105207565	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr14:105207565C>T	uc001ypd.2	+	8	852	c.778C>T	c.(778-780)CTC>TTC	p.L260F	INF2_uc010tyi.1_Intron|ADSSL1_uc001ype.2_Missense_Mutation_p.L303F|ADSSL1_uc001ypf.2_RNA	NM_152328	NP_689541	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1 isoform 2	260					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(1)|central_nervous_system(1)	2		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	CGCCGCCCTCCTCGACATTGA	0.617		NA											20	33					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105406529	105406529	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr14:105406529G>A	uc010axc.1	-	7	15379	c.15259C>T	c.(15259-15261)CTC>TTC	p.L5087F	AHNAK2_uc001ypx.2_Missense_Mutation_p.L4987F	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	5087						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGCCGGTGGAGGTTCACACCC	0.572		NA											42	95					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105410194	105410194	+	Missense_Mutation	SNP	C	C	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr14:105410194C>A	uc010axc.1	-	7	11714	c.11594G>T	c.(11593-11595)CGC>CTC	p.R3865L	AHNAK2_uc001ypx.2_Missense_Mutation_p.R3765L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3865						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GTCCACCTGGCGAGCTTGGAC	0.607		NA											82	189					9.35e-44	1.98e-43	1	0
MKRN3	7681	broad.mit.edu	37	15	23811447	23811447	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr15:23811447C>T	uc001ywh.3	+	1	994	c.518C>T	c.(517-519)TCG>TTG	p.S173L	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.S173L	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	173						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GTGATTGGCTCGGCTGCTGAA	0.612		NA											26	29					0	0	0	0
GPR176	11245	broad.mit.edu	37	15	40093386	40093386	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr15:40093386G>A	uc001zkj.1	-	3	2361	c.1495C>T	c.(1495-1497)CGG>TGG	p.R499W	GPR176_uc010uck.1_Missense_Mutation_p.R439W	NM_007223	NP_009154	Q14439	GP176_HUMAN	G protein-coupled receptor 176	499	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		all_cancers(109;4.05e-15)|all_epithelial(112;2.96e-13)|Lung NSC(122;8.53e-11)|all_lung(180;2.71e-09)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;4.4e-06)|BRCA - Breast invasive adenocarcinoma(123;0.123)		CTCATCTTCCGCTCCACCCTG	0.512		NA											42	81					0	0	0	0
UACA	55075	broad.mit.edu	37	15	70960561	70960561	+	Missense_Mutation	SNP	A	A	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr15:70960561A>G	uc002asr.2	-	16	2566	c.2462T>C	c.(2461-2463)GTT>GCT	p.V821A	UACA_uc010uke.1_Missense_Mutation_p.V712A|UACA_uc002asq.2_Missense_Mutation_p.V808A|UACA_uc010bin.1_Missense_Mutation_p.V796A	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	821	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						CTTAAGTTCAACAATATTGGA	0.368		NA											3	83					0	0	0	0
MSLN	10232	broad.mit.edu	37	16	815234	815234	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr16:815234C>T	uc002cjw.1	+	8	686	c.635C>T	c.(634-636)CCG>CTG	p.P212L	MSLN_uc002cjt.1_Missense_Mutation_p.P212L|MSLN_uc002cju.1_Missense_Mutation_p.P212L|MSLN_uc010brd.1_Missense_Mutation_p.P211L|MSLN_uc002cjv.1_Missense_Mutation_p.P212L|MSLN_uc002cjx.1_Missense_Mutation_p.P212L|MSLN_uc002cjy.1_5'Flank	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	212					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane		p.P212P(1)		pancreas(1)	1		Hepatocellular(780;0.00335)				GTGAGCTGCCCGGGACCCCTG	0.697		NA											4	10					0	0	0	0
CASKIN1	57524	broad.mit.edu	37	16	2239445	2239445	+	Missense_Mutation	SNP	G	G	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr16:2239445G>T	uc010bsg.1	-	4	397	c.365C>A	c.(364-366)GCG>GAG	p.A122E		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	122	ANK 3.				signal transduction	cytoplasm				skin(2)	2						ATGCTGGGCCGCCAGGTGCAG	0.547		NA											5	26					0.000602214	0.00119648	1	0
DCUN1D3	123879	broad.mit.edu	37	16	20871625	20871625	+	Silent	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr16:20871625G>A	uc002dhz.2	-	3	639	c.498C>T	c.(496-498)TTC>TTT	p.F166F	ERI2_uc002dht.3_Intron	NM_173475	NP_775746	Q8IWE4	DCNL3_HUMAN	DCN1, defective in cullin neddylation 1, domain	166	DCUN1.				negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of apoptosis|response to gamma radiation|response to UV-C	perinuclear region of cytoplasm				ovary(2)	2				GBM - Glioblastoma multiforme(48;0.249)		AGAGGCTAGGGAACCGTGCAC	0.443		NA											31	67					0	0	0	0
EEF2K	29904	broad.mit.edu	37	16	22260121	22260121	+	Missense_Mutation	SNP	C	C	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr16:22260121C>G	uc002dki.2	+	4	878	c.393C>G	c.(391-393)ATC>ATG	p.I131M	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	131	Alpha-type protein kinase.				insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)		AAGTTCTGATCAAGATGGCAT	0.567		NA											8	35					0	0	0	0
CNGB1	1258	broad.mit.edu	37	16	58001090	58001090	+	Missense_Mutation	SNP	T	T	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr16:58001090T>C	uc002emt.2	-	2	166	c.101A>G	c.(100-102)GAG>GGG	p.E34G	CNGB1_uc010cdh.2_Missense_Mutation_p.E34G|CNGB1_uc002emu.2_Missense_Mutation_p.E34G	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	34	Glu-rich.				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						CACCTCCGCCTCCATCTCTGG	0.642		NA											3	81					0	0	0	0
CMTM1	113540	broad.mit.edu	37	16	66603924	66603924	+	Missense_Mutation	SNP	T	T	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr16:66603924T>C	uc002epi.3	+	2	290	c.167T>C	c.(166-168)ATT>ACT	p.I56T	CMTM1_uc002epb.3_RNA|CMTM1_uc002epc.3_RNA|CMTM1_uc002epd.3_Intron|CMTM1_uc002epe.3_Intron|CMTM1_uc002epf.3_Intron|CMTM1_uc002epg.3_Intron|CMTM1_uc002eph.3_Missense_Mutation_p.I56T|CMTM1_uc002epl.3_Intron|CMTM1_uc002epj.3_Intron|CMTM1_uc002epk.3_Intron|CMTM1_uc002epa.3_Intron|CMTM1_uc002epn.3_Missense_Mutation_p.I173T|CMTM1_uc002epo.3_RNA|CMTM1_uc002epp.3_RNA|CMTM1_uc002epq.3_RNA|CMTM1_uc010cds.2_RNA|CMTM1_uc002epr.3_Missense_Mutation_p.I173T|CMTM1_uc002epm.3_RNA|CMTM1_uc002eps.2_RNA	NM_181269	NP_851786	Q8IZ96	CKLF1_HUMAN	chemokine-like factor superfamily 1 isoform 1	56	MARVEL.|Helical; (Potential).				chemotaxis	extracellular space|integral to membrane	cytokine activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0702)|Epithelial(162;0.222)		GAAATCTGCATTGTCGTTTTT	0.343		NA											49	103					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578262	7578262	+	Missense_Mutation	SNP	C	C	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr17:7578262C>G	uc002gim.2	-	6	781	c.587G>C	c.(586-588)CGA>CCA	p.R196P	TP53_uc002gig.1_Missense_Mutation_p.R196P|TP53_uc002gih.2_Missense_Mutation_p.R196P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R64P|TP53_uc010cng.1_Missense_Mutation_p.R64P|TP53_uc002gii.1_Missense_Mutation_p.R64P|TP53_uc010cnh.1_Missense_Mutation_p.R196P|TP53_uc010cni.1_Missense_Mutation_p.R196P|TP53_uc002gij.2_Missense_Mutation_p.R196P|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.R103P|TP53_uc002gio.2_Missense_Mutation_p.R64P|TP53_uc010vug.1_Missense_Mutation_p.R157P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	196	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R196*(123)|p.R196P(12)|p.0?(7)|p.R196R(5)|p.R196fs*51(4)|p.A189_V197delAPPQHLIRV(4)|p.R196Q(3)|p.K164_P219del(1)|p.I195fs*50(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.R196L(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCCTTCCACTCGGATAAGATG	0.547		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	17					0	0	0	0
CCDC144A	9720	broad.mit.edu	37	17	16612722	16612722	+	Missense_Mutation	SNP	A	A	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr17:16612722A>T	uc002gqk.1	+	5	1427	c.1351A>T	c.(1351-1353)ACA>TCA	p.T451S	CCDC144A_uc002gql.1_Intron|LOC162632_uc010cpj.1_5'Flank	NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	451											0						TTTGCAAATGACAAAAAATAT	0.343		NA											24	26					0	0	0	0
PIGW	284098	broad.mit.edu	37	17	34893502	34893502	+	Silent	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr17:34893502G>A	uc002hmy.1	+	2	595	c.552G>A	c.(550-552)GAG>GAA	p.E184E	MYO19_uc002hmw.2_5'Flank|MYO19_uc010cuu.2_5'Flank|MYO19_uc010wcy.1_5'Flank|MYO19_uc010wcz.1_5'Flank|MYO19_uc010wda.1_5'Flank|MYO19_uc002hmx.2_5'Flank|PIGW_uc002hmz.1_Silent_p.E184E	NM_178517	NP_848612	Q7Z7B1	PIGW_HUMAN	phosphatidylinositol glycan, class W	184					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	O-acyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TTTGTCTAGAGGTCAGGAGGA	0.418		NA											36	150					0	0	0	0
TBX21	30009	broad.mit.edu	37	17	45822604	45822604	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr17:45822604G>A	uc002ilv.1	+	6	1691	c.1480G>A	c.(1480-1482)GAA>AAA	p.E494K		NM_013351	NP_037483	Q9UL17	TBX21_HUMAN	T-box 21	494					lymphocyte migration|multicellular organismal development|positive regulation of transcription, DNA-dependent|response to virus	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0						AGGACTGGGCGAAGGAGACTC	0.617		NA											9	42					0	0	0	0
TRIM37	4591	broad.mit.edu	37	17	57119177	57119177	+	Missense_Mutation	SNP	C	C	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr17:57119177C>A	uc002iwy.3	-	17	2194	c.1750G>T	c.(1750-1752)GCA>TCA	p.A584S	TRIM37_uc002iwz.3_Missense_Mutation_p.A584S|TRIM37_uc002ixa.3_Missense_Mutation_p.A462S|TRIM37_uc010woc.1_Missense_Mutation_p.A550S	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	584						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					TCATTACCTGCGGGTCCTGCA	0.423		NA							Mulibrey_Nanism				7	19					0.00307968	0.00603906	1	0
C17orf56	146705	broad.mit.edu	37	17	79204412	79204412	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr17:79204412G>A	uc002jzu.1	-	11	983	c.961C>T	c.(961-963)CGC>TGC	p.R321C	C17orf56_uc002jzr.1_5'UTR|C17orf56_uc002jzs.1_Missense_Mutation_p.R237C|C17orf56_uc002jzt.1_Missense_Mutation_p.R237C|C17orf56_uc002jzv.1_Missense_Mutation_p.R169C|uc002jzw.1_RNA	NM_144679	NP_653280	Q96N21	CQ056_HUMAN	hypothetical protein LOC146705	321						integral to membrane					0	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GGCCGGGTGCGGAGGAGGATG	0.697		NA									OREG0024811	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	25					0	0	0	0
HMHA1	23526	broad.mit.edu	37	19	1082981	1082981	+	Missense_Mutation	SNP	T	T	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:1082981T>A	uc002lqz.1	+	20	2891	c.2660T>A	c.(2659-2661)CTG>CAG	p.L887Q	HMHA1_uc010xgd.1_Missense_Mutation_p.L903Q|HMHA1_uc010xge.1_Missense_Mutation_p.L755Q|HMHA1_uc002lra.1_Missense_Mutation_p.L727Q|HMHA1_uc002lrb.1_Missense_Mutation_p.L770Q|HMHA1_uc002lrc.1_Missense_Mutation_p.L522Q|HMHA1_uc002lrd.1_5'UTR|HMHA1_uc010dsd.1_5'UTR	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	887	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGTGGCCCTGGCAGGTCGG	0.716		NA											5	8					0	0	0	0
ZNF700	90592	broad.mit.edu	37	19	12060456	12060456	+	Missense_Mutation	SNP	C	C	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:12060456C>G	uc002msu.2	+	4	1743	c.1617C>G	c.(1615-1617)AAC>AAG	p.N539K	ZNF700_uc010xme.1_Missense_Mutation_p.N557K|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	539	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATGAATGCAACCAATGTGGTA	0.398		NA											3	87					0	0	0	0
ZNF136	7695	broad.mit.edu	37	19	12296615	12296615	+	Missense_Mutation	SNP	G	G	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:12296615G>C	uc002mti.2	+	2	119	c.19G>C	c.(19-21)GAG>CAG	p.E7Q	ZNF136_uc010xmh.1_Intron	NM_003437	NP_003428	P52737	ZN136_HUMAN	zinc finger protein 136	7	KRAB.				negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|pancreas(1)	2						GGTGGCTTTTGAGGATGTAGA	0.478		NA											13	59					0	0	0	0
MAST3	23031	broad.mit.edu	37	19	18232573	18232573	+	Silent	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:18232573G>A	uc002nhz.3	+	3	150	c.150G>A	c.(148-150)TCG>TCA	p.S50S		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	50							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						CGCCATTGTCGGTCCCAACGG	0.687		NA											29	83					0	0	0	0
PDCD2L	84306	broad.mit.edu	37	19	34895682	34895682	+	Silent	SNP	G	G	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:34895682G>T	uc002nvj.2	+	2	270	c.237G>T	c.(235-237)GCG>GCT	p.A79A		NM_032346	NP_115722	Q9BRP1	PDD2L_HUMAN	programmed cell death 2-like	79						cytoplasm				ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			ACGTGTTCGCGTGCGCCTGCC	0.716		NA											5	11					0.00116845	0.00231537	1	0
FCGBP	8857	broad.mit.edu	37	19	40367841	40367841	+	Silent	SNP	T	T	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:40367841T>G	uc002omp.3	-	29	13127	c.13119A>C	c.(13117-13119)GCA>GCC	p.A4373A		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4373	TIL 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TCGTAAGGGGTGCAGGGGACG	0.627		NA											10	34					0	0	0	0
PSMC4	5704	broad.mit.edu	37	19	40478119	40478119	+	Missense_Mutation	SNP	G	G	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:40478119G>C	uc002omq.2	+	2	140	c.103G>C	c.(103-105)GAG>CAG	p.E35Q	PSMC4_uc002omr.2_Missense_Mutation_p.E35Q	NM_006503	NP_006494	P43686	PRS6B_HUMAN	proteasome 26S ATPase subunit 4 isoform 1	35					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			ovary(1)	1	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CCCTGAGCCTGAGGACCTGGA	0.582		NA											24	82					0	0	0	0
ZNF574	64763	broad.mit.edu	37	19	42584376	42584376	+	Missense_Mutation	SNP	C	C	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:42584376C>A	uc002osm.3	+	2	1787	c.1618C>A	c.(1618-1620)CGC>AGC	p.R540S	ZNF574_uc002osk.3_Missense_Mutation_p.R630S	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	540	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				CAACCTGGCCCGCCACCGGCT	0.642		NA											8	277					0.00448238	0.00876684	1	0
FAM83E	54854	broad.mit.edu	37	19	49104463	49104463	+	Missense_Mutation	SNP	C	C	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:49104463C>G	uc002pjn.2	-	5	1405	c.1340G>C	c.(1339-1341)AGG>ACG	p.R447T		NM_017708	NP_060178	Q2M2I3	FA83E_HUMAN	hypothetical protein LOC54854	447										ovary(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		ACCGAACCGCCTTCGGGCTGG	0.701		NA											11	30					0	0	0	0
ZNF845	91664	broad.mit.edu	37	19	53855570	53855570	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:53855570G>A	uc010ydv.1	+	4	1759	c.1642G>A	c.(1642-1644)GAG>AAG	p.E548K	ZNF845_uc010ydw.1_Missense_Mutation_p.E548K	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	548					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCATACTGGAGAGAAACCTTA	0.413		NA											6	75					0	0	0	0
ZNF132	7691	broad.mit.edu	37	19	58944808	58944808	+	Missense_Mutation	SNP	G	G	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:58944808G>C	uc002qst.3	-	3	2404	c.2003C>G	c.(2002-2004)TCT>TGT	p.S668C		NM_003433	NP_003424	P52740	ZN132_HUMAN	zinc finger protein 132	668	C2H2-type 17.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		AACAAGTGTAGATCTTTCACT	0.468		NA											7	64					0	0	0	0
SLC5A7	60482	broad.mit.edu	37	2	108622649	108622649	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr2:108622649G>A	uc002tdv.2	+	7	1162	c.886G>A	c.(886-888)GCA>ACA	p.A296T	SLC5A7_uc010ywm.1_Missense_Mutation_p.A49T|SLC5A7_uc010fjj.2_Missense_Mutation_p.A296T|SLC5A7_uc010ywn.1_Missense_Mutation_p.A183T	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	296	Cytoplasmic (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	GGCCATTGGAGCATCAACAGG	0.542		NA											23	70					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179434249	179434249	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr2:179434249C>T	uc010zfg.1	-	275	69130	c.68906G>A	c.(68905-68907)CGT>CAT	p.R22969H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R16664H|TTN_uc010zfi.1_Missense_Mutation_p.R16597H|TTN_uc010zfj.1_Missense_Mutation_p.R16472H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23896							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGTGTAGGACGACCTTTTAT	0.393		NA											4	42					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179648932	179648932	+	Silent	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr2:179648932C>T	uc010zfg.1	-	16	2864	c.2640G>A	c.(2638-2640)CAG>CAA	p.Q880Q	TTN_uc010zfh.1_Silent_p.Q834Q|TTN_uc010zfi.1_Silent_p.Q834Q|TTN_uc010zfj.1_Silent_p.Q834Q|TTN_uc002unb.2_Silent_p.Q880Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	880							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGAAGGGGAACTGTGGCAAGG	0.537		NA											17	65					0	0	0	0
PDE1A	5136	broad.mit.edu	37	2	183033014	183033014	+	Missense_Mutation	SNP	G	G	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr2:183033014G>C	uc002uos.2	-	15	1652	c.1568C>G	c.(1567-1569)GCA>GGA	p.A523G	PDE1A_uc010zfp.1_Intron|PDE1A_uc002uoq.1_Intron|PDE1A_uc010zfq.1_Intron|PDE1A_uc002uor.2_Missense_Mutation_p.A507G|PDE1A_uc002uou.2_Missense_Mutation_p.A489G	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	523					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			ACTGGTTCTTGCTTCTGAAAA	0.318		NA											10	35					0	0	0	0
HECW2	57520	broad.mit.edu	37	2	197189757	197189757	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr2:197189757C>T	uc002utm.1	-	6	871	c.688G>A	c.(688-690)GAG>AAG	p.E230K	HECW2_uc002utl.1_5'UTR	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	230	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GACCGTCTCTCCTGCCCGTGG	0.498		NA											62	184					0	0	0	0
NDUFB3	4709	broad.mit.edu	37	2	201950235	201950235	+	Missense_Mutation	SNP	A	A	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr2:201950235A>C	uc002uwx.3	+	3	517	c.194A>C	c.(193-195)GAT>GCT	p.D65A		NM_002491	NP_002482	O43676	NDUB3_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	65					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	TCCTTTTCTGATGTATTCTTT	0.363		NA											3	68					0	0	0	0
NBEAL1	65065	broad.mit.edu	37	2	204078305	204078305	+	Missense_Mutation	SNP	G	G	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr2:204078305G>C	uc002uzt.3	+	54	8245	c.7912G>C	c.(7912-7914)GAA>CAA	p.E2638Q	NBEAL1_uc002uzs.3_Missense_Mutation_p.E1279Q|NBEAL1_uc002uzu.2_Missense_Mutation_p.E133Q	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	2638							binding			ovary(1)|skin(1)	2						TGTCACCAAAGAATACAGCCA	0.383		NA											35	93					0	0	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884679	228884679	+	Silent	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr2:228884679C>T	uc002vpq.2	-	7	938	c.891G>A	c.(889-891)CAG>CAA	p.Q297Q	SPHKAP_uc002vpp.2_Silent_p.Q297Q|SPHKAP_uc010zlx.1_Silent_p.Q297Q	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	297						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GATCTAGACTCTGCAAGGCTG	0.418		NA											60	162					0	0	0	0
PLCB1	23236	broad.mit.edu	37	20	8713951	8713951	+	Missense_Mutation	SNP	C	C	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr20:8713951C>A	uc002wnb.2	+	19	1958	c.1955C>A	c.(1954-1956)CCA>CAA	p.P652Q	PLCB1_uc010zrb.1_Missense_Mutation_p.P551Q|PLCB1_uc002wna.2_Missense_Mutation_p.P652Q|PLCB1_uc002wnc.1_Missense_Mutation_p.P551Q|PLCB1_uc002wnd.1_Missense_Mutation_p.P229Q	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	652	PI-PLC Y-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						AGATTGAAGCCAGAGTTCATG	0.423		NA											15	67					2.32e-05	4.66e-05	1	0
NINL	22981	broad.mit.edu	37	20	25457633	25457633	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr20:25457633G>A	uc002wux.1	-	17	2368	c.2294C>T	c.(2293-2295)CCG>CTG	p.P765L	NINL_uc010gdn.1_Intron	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	765					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GGGTCCCTGCGGCGGCTCCTC	0.692		NA											12	7					0	0	0	0
DIDO1	11083	broad.mit.edu	37	20	61512690	61512690	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr20:61512690G>A	uc002ydr.1	-	16	4882	c.4618C>T	c.(4618-4620)CAG>TAG	p.Q1540*	DIDO1_uc002yds.1_Nonsense_Mutation_p.Q1540*	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1540					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					TCTGCAGACTGCTGCTCTTGC	0.667		NA											45	54					0	0	0	0
DIDO1	11083	broad.mit.edu	37	20	61542922	61542922	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr20:61542922C>T	uc002ydr.1	-	3	307	c.43G>A	c.(43-45)GCC>ACC	p.A15T	DIDO1_uc002yds.1_Missense_Mutation_p.A15T|DIDO1_uc002ydt.1_Missense_Mutation_p.A15T|DIDO1_uc002ydu.1_Missense_Mutation_p.A15T|DIDO1_uc002ydv.1_Missense_Mutation_p.A15T|DIDO1_uc002ydw.1_Missense_Mutation_p.A15T|DIDO1_uc002ydx.1_Missense_Mutation_p.A15T|DIDO1_uc011aao.1_Missense_Mutation_p.A15T	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	15					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GGTTTGATGGCCTTAGGTGCC	0.542		NA											12	13					0	0	0	0
ZNF512B	57473	broad.mit.edu	37	20	62597655	62597655	+	Silent	SNP	G	G	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr20:62597655G>T	uc002yhl.1	-	5	927	c.873C>A	c.(871-873)ACC>ACA	p.T291T		NM_020713	NP_065764	Q96KM6	Z512B_HUMAN	zinc finger protein 512B	291					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					TCACTGGCTTGGTGACCGGCA	0.557		NA											8	214					0.000219431	0.000438281	1	0
U2AF1	7307	broad.mit.edu	37	21	44524445	44524445	+	Missense_Mutation	SNP	T	T	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr21:44524445T>G	uc002zda.1	-	2	196	c.112A>C	c.(112-114)AAT>CAT	p.N38H	U2AF1_uc002zcy.1_5'UTR|U2AF1_uc002zcz.1_5'UTR|U2AF1_uc002zdb.1_Missense_Mutation_p.N38H|U2AF1_uc010gpi.1_Missense_Mutation_p.N38H|U2AF1_uc002zdc.1_Missense_Mutation_p.N38H	NM_001025203	NP_001020374	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxillary factor 1 isoform	38	C3H1-type 1.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding				0						GTCGGTTTATTGTGCAACCGA	0.343		NA											6	16					0	0	0	0
EP300	2033	broad.mit.edu	37	22	41564727	41564727	+	Missense_Mutation	SNP	T	T	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr22:41564727T>G	uc003azl.3	+	25	4423	c.4028T>G	c.(4027-4029)TTT>TGT	p.F1343C		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1343					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TTGTATAGGTTTGTGGACAGT	0.443		NA	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				17	46					0	0	0	0
PLCL2	23228	broad.mit.edu	37	3	17084400	17084400	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr3:17084400C>T	uc011awc.1	+	7	3134	c.3029C>T	c.(3028-3030)GCA>GTA	p.A1010V	PLCL2_uc011awd.1_Missense_Mutation_p.A892V	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	1018					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						ATTGAAAATGCAGATGCTGTA	0.403		NA											30	41					0	0	0	0
SMARCC1	6599	broad.mit.edu	37	3	47703871	47703871	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr3:47703871G>A	uc003crq.2	-	20	2229	c.2111C>T	c.(2110-2112)TCT>TTT	p.S704F	SMARCC1_uc011bbc.1_RNA|SMARCC1_uc011bbd.1_Missense_Mutation_p.S595F	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	704					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		GTCCACCACAGATGCCAAAAA	0.493		NA											9	21					0	0	0	0
ERC2	26059	broad.mit.edu	37	3	56468821	56468821	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr3:56468821G>T	uc003dhr.1	-	2	471	c.215C>A	c.(214-216)TCA>TAA	p.S72*		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	72						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GTAGGTTGTTGAAGCCACCCC	0.507		NA											46	70					6.77e-33	1.43e-32	1	0
CLSTN2	64084	broad.mit.edu	37	3	140251315	140251315	+	Silent	SNP	C	C	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr3:140251315C>A	uc003etn.2	+	9	1684	c.1494C>A	c.(1492-1494)GGC>GGA	p.G498G	CLSTN2_uc003etm.2_Silent_p.G498G	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	498	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						TCACAGTCGGCGCTTGTTGGC	0.443		NA								HNSCC(16;0.037)			24	72					0.000117367	0.000235046	1	0
YEATS2	55689	broad.mit.edu	37	3	183469895	183469895	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr3:183469895G>A	uc003fly.2	+	10	1199	c.1004G>A	c.(1003-1005)GGA>GAA	p.G335E		NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	335					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CATTCTCTCGGAGAAGACTGT	0.493		NA											49	117					0	0	0	0
EIF4G1	1981	broad.mit.edu	37	3	184043328	184043328	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr3:184043328G>T	uc003fnp.2	+	20	3220	c.3022G>T	c.(3022-3024)GAG>TAG	p.E1008*	EIF4G1_uc003fnt.2_Nonsense_Mutation_p.E719*|EIF4G1_uc003fnq.2_Nonsense_Mutation_p.E921*|EIF4G1_uc003fnr.2_Nonsense_Mutation_p.E844*|EIF4G1_uc010hxx.2_Nonsense_Mutation_p.E1015*|EIF4G1_uc003fns.2_Nonsense_Mutation_p.E968*|EIF4G1_uc010hxy.2_Nonsense_Mutation_p.E1015*|EIF4G1_uc003fnv.3_Nonsense_Mutation_p.E1009*|EIF4G1_uc003fnu.3_Nonsense_Mutation_p.E1008*|EIF4G1_uc003fnw.2_Nonsense_Mutation_p.E1015*|EIF4G1_uc003fnx.2_Nonsense_Mutation_p.E813*|EIF4G1_uc003fny.3_Nonsense_Mutation_p.E812*|SNORD66_uc003fnz.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1008	eIF3/EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GATCCATAAGGAGGCTGAGAT	0.587		NA											48	122					5.49e-27	1.15e-26	1	0
EIF4G1	1981	broad.mit.edu	37	3	184045463	184045463	+	Missense_Mutation	SNP	G	G	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr3:184045463G>C	uc003fnp.2	+	25	3949	c.3751G>C	c.(3751-3753)GAG>CAG	p.E1251Q	EIF4G1_uc003fnt.2_Missense_Mutation_p.E962Q|EIF4G1_uc003fnq.2_Missense_Mutation_p.E1164Q|EIF4G1_uc003fnr.2_Missense_Mutation_p.E1087Q|EIF4G1_uc010hxx.2_Missense_Mutation_p.E1258Q|EIF4G1_uc003fns.2_Missense_Mutation_p.E1211Q|EIF4G1_uc010hxy.2_Missense_Mutation_p.E1258Q|EIF4G1_uc003fnv.3_Missense_Mutation_p.E1252Q|EIF4G1_uc003fnu.3_Missense_Mutation_p.E1251Q|EIF4G1_uc003fnw.2_Missense_Mutation_p.E1258Q|EIF4G1_uc003fnx.2_Missense_Mutation_p.E1056Q|EIF4G1_uc003fny.3_Missense_Mutation_p.E1055Q|EIF4G1_uc003foa.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1251	MI.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGCTATCATTGAGGAATATCT	0.557		NA											28	74					0	0	0	0
HRG	3273	broad.mit.edu	37	3	186392970	186392970	+	Silent	SNP	C	C	T	rs151028119		TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr3:186392970C>T	uc003fqq.2	+	6	755	c.732C>T	c.(730-732)TTC>TTT	p.F244F		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	244	Cystatin 2.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		GTGAAGTCTTCGACCCTCAGG	0.428		NA											28	243					0	0	0	0
LRRC33	375387	broad.mit.edu	37	3	196381413	196381413	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr3:196381413G>A	uc003fwv.2	+	2	107	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_198565	NP_940967	Q86YC3	LRC33_HUMAN	leucine rich repeat containing 33 precursor	1						integral to membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.9e-23)|all cancers(36;1.76e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		CCCTTGAGATGGAGTTGCTGC	0.567		NA											13	58					0	0	0	0
FRYL	285527	broad.mit.edu	37	4	48622739	48622739	+	Silent	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr4:48622739G>A	uc003gyh.1	-	6	836	c.231C>T	c.(229-231)ACC>ACT	p.T77T	FRYL_uc003gyk.2_Silent_p.T77T|FRYL_uc003gyl.1_Silent_p.T128T|FRYL_uc003gym.1_Silent_p.T77T	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	77					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						AGTCAAACAAGGTGCGAAGTA	0.398		NA											26	48					0	0	0	0
HELQ	113510	broad.mit.edu	37	4	84352817	84352817	+	Silent	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr4:84352817C>T	uc003hom.2	-	11	2474	c.2295G>A	c.(2293-2295)AAG>AAA	p.K765K	HELQ_uc010ikb.2_Silent_p.K698K|HELQ_uc003hol.3_RNA|HELQ_uc010ikc.2_RNA	NM_133636	NP_598375	Q8TDG4	HELQ_HUMAN	DNA helicase HEL308	765							ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|breast(1)|skin(1)	3						AGAAAAATACCTTCAAACCAA	0.289		NA						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					12	29					0	0	0	0
WDFY3	23001	broad.mit.edu	37	4	85707147	85707147	+	Silent	SNP	T	T	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr4:85707147T>C	uc003hpd.2	-	24	4455	c.4047A>G	c.(4045-4047)AAA>AAG	p.K1349K		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1349						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TAGCAATGGCTTTGCTATCCA	0.418		NA											24	46					0	0	0	0
AFF1	4299	broad.mit.edu	37	4	87968051	87968051	+	Missense_Mutation	SNP	T	T	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr4:87968051T>C	uc003hqj.3	+	3	750	c.343T>C	c.(343-345)TCC>CCC	p.S115P	AFF1_uc011ccx.1_Missense_Mutation_p.S56P|AFF1_uc003hqh.1_Missense_Mutation_p.S122P|AFF1_uc011ccy.1_Missense_Mutation_p.S122P|AFF1_uc011ccz.1_Missense_Mutation_p.S122P|AFF1_uc003hqk.3_Missense_Mutation_p.S115P|AFF1_uc011cda.1_Intron	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	115						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		CCACCACCAGTCCATTCACAC	0.488		NA											18	98					0	0	0	0
SPP1	6696	broad.mit.edu	37	4	88903947	88903947	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr4:88903947G>T	uc003hra.2	+	7	1009	c.844G>T	c.(844-846)GAA>TAA	p.E282*	SPP1_uc003hrb.2_Nonsense_Mutation_p.E255*|SPP1_uc003hrc.2_Nonsense_Mutation_p.E268*|SPP1_uc011cde.1_Nonsense_Mutation_p.E295*|SPP1_uc003hrd.2_Nonsense_Mutation_p.E241*	NM_001040058	NP_001035147	P10451	OSTP_HUMAN	secreted phosphoprotein 1 isoform a	282					biomineral tissue development|cell adhesion|decidualization|embryo implantation|ossification|response to vitamin D	extracellular space	cytokine activity			ovary(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-05)		TCACAGCCATGAAGATATGCT	0.398		NA											11	108					0.00185496	0.0036661	1	0
ENPEP	2028	broad.mit.edu	37	4	111397718	111397718	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr4:111397718G>A	uc003iab.3	+	1	490	c.148G>A	c.(148-150)GGG>AGG	p.G50R		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	50	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CGGGGACGGCGGGCCGGGCAC	0.642		NA											38	108					0	0	0	0
RXFP3	51289	broad.mit.edu	37	5	33937017	33937017	+	Missense_Mutation	SNP	G	G	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr5:33937017G>T	uc003jic.1	+	1	529	c.172G>T	c.(172-174)GAC>TAC	p.D58Y		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	58	Extracellular (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						GGAGTTGCCGGACGGCGCGCC	0.687		NA											41	59					1.16e-17	2.41e-17	1	0
SKP2	6502	broad.mit.edu	37	5	36152987	36152987	+	Silent	SNP	G	G	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr5:36152987G>C	uc003jkc.1	+	2	305	c.123G>C	c.(121-123)CTG>CTC	p.L41L	SKP2_uc011cou.1_5'UTR|SKP2_uc003jkd.2_Silent_p.L41L|LMBRD2_uc003jkb.1_5'Flank	NM_005983	NP_005974	Q13309	SKP2_HUMAN	S-phase kinase-associated protein 2 isoform 1	41					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G1/S transition of mitotic cell cycle|S phase of mitotic cell cycle	nucleoplasm|SCF ubiquitin ligase complex	protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4	all_lung(31;5.63e-05)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCTCCGCCCTGGAGAAAGAGG	0.592		NA											14	43					0	0	0	0
CCNB1	891	broad.mit.edu	37	5	68471233	68471233	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr5:68471233G>A	uc003jvm.2	+	7	1129	c.952G>A	c.(952-954)GAG>AAG	p.E318K	CCNB1_uc011crd.1_Missense_Mutation_p.E318K|CCNB1_uc010ixb.2_Missense_Mutation_p.E318K	NM_031966	NP_114172	P14635	CCNB1_HUMAN	cyclin B1	318					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle spindle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|mitotic spindle stabilization|positive regulation of attachment of spindle microtubules to kinetochore|positive regulation of mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	condensed nuclear chromosome outer kinetochore|cytosol|microtubule organizing center|nucleoplasm|spindle pole					0		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		GGTTGATGTCGAGCAACATAC	0.393		NA											23	79					0	0	0	0
RGNEF	64283	broad.mit.edu	37	5	73205674	73205674	+	Silent	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr5:73205674C>T	uc011csq.1	+	33	4610	c.4599C>T	c.(4597-4599)CAC>CAT	p.H1533H	RGNEF_uc003kcx.2_Silent_p.H1533H|RGNEF_uc010izf.2_Silent_p.H1533H|RGNEF_uc011csr.1_Silent_p.H1220H|RGNEF_uc003kcz.3_Silent_p.H497H|RGNEF_uc003kda.3_Silent_p.H453H	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	1533	Interaction with microtubules (By similarity).				cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		ACTGGAAGCACGGCCGGCAGA	0.706		NA											7	6					0	0	0	0
ERAP1	51752	broad.mit.edu	37	5	96121617	96121617	+	Silent	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr5:96121617G>A	uc003kmm.2	-	13	2165	c.1818C>T	c.(1816-1818)GGC>GGT	p.G606G	ERAP1_uc003kml.2_Silent_p.G606G|ERAP1_uc010jbm.1_Silent_p.G418G|ERAP1_uc003kmn.2_Silent_p.G606G	NM_001040458	NP_001035548	Q9NZ08	ERAP1_HUMAN	type 1 tumor necrosis factor receptor shedding	606	Lumenal (Potential).				angiogenesis|antigen processing and presentation of endogenous peptide antigen via MHC class I|fat cell differentiation|membrane protein ectodomain proteolysis|regulation of blood pressure|regulation of innate immune response|response to bacterium	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|integral to membrane	aminopeptidase activity|interleukin-1, Type II receptor binding|interleukin-6 receptor binding|metalloexopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		all_cancers(142;1.75e-06)|all_epithelial(76;3.08e-09)|all_lung(232;0.000435)|Lung NSC(167;0.000601)|Ovarian(225;0.024)|Colorectal(57;0.0432)|Breast(839;0.244)		all cancers(79;7.26e-15)|COAD - Colon adenocarcinoma(37;0.071)		CAATGTAATAGCCATTCATGC	0.428		NA											30	31					0	0	0	0
SEC24A	10802	broad.mit.edu	37	5	134033594	134033594	+	Missense_Mutation	SNP	A	A	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr5:134033594A>G	uc003kzs.2	+	15	2401	c.2113A>G	c.(2113-2115)ATT>GTT	p.I705V	SEC24A_uc011cxu.1_Missense_Mutation_p.I469V	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	705					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCCAGGTTGTATTTCTCGGTA	0.373		NA											47	50					0	0	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236912	140236912	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr5:140236912C>T	uc003lhx.2	+	1	1279	c.1279C>T	c.(1279-1281)CGG>TGG	p.R427W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.R427W|PCDHA10_uc011dad.1_Missense_Mutation_p.R427W	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	427	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGACCGCGCGGGACGGGGG	0.647		NA											8	209					0	0	0	0
HIST1H3C	8352	broad.mit.edu	37	6	26045674	26045674	+	Silent	SNP	C	C	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:26045674C>G	uc003nfv.2	+	1	36	c.36C>G	c.(34-36)ACC>ACG	p.T12T	HIST1H2BB_uc003nfu.2_5'Flank	NM_003531	NP_003522	P68431	H31_HUMAN	histone cluster 1, H3c	12					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						GCAAGTCTACCGGCGGCAAAG	0.547		NA											16	65					0	0	0	0
SCAND3	114821	broad.mit.edu	37	6	28541559	28541559	+	Missense_Mutation	SNP	C	C	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:28541559C>G	uc003nlo.2	-	4	2725	c.2107G>C	c.(2107-2109)GCC>CCC	p.A703P		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	703					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						tcagaaaaggcatgtcttttc	0		NA											2	9					0	0	0	0
OR2H2	7932	broad.mit.edu	37	6	29555789	29555789	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:29555789G>A	uc003nmr.1	+	1	107	c.68G>A	c.(67-69)AGG>AAG	p.R23K	GABBR1_uc003nmp.3_Intron	NM_007160	NP_009091	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H,	23	Extracellular (Potential).				defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGGCTGGAAAGGACTCTCTTC	0.557		NA											52	150					0	0	0	0
BAT1	7919	broad.mit.edu	37	6	31504459	31504459	+	Missense_Mutation	SNP	A	A	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:31504459A>C	uc003ntt.2	-	5	1065	c.434T>G	c.(433-435)GTT>GGT	p.V145G	BAT1_uc003ntr.2_5'Flank|BAT1_uc003nts.2_Missense_Mutation_p.V145G|BAT1_uc011dnn.1_Missense_Mutation_p.V67G|BAT1_uc003ntu.2_Missense_Mutation_p.V145G|BAT1_uc003ntv.2_Missense_Mutation_p.V145G|BAT1_uc003ntw.2_Missense_Mutation_p.V145G|BAT1_uc003ntx.2_Missense_Mutation_p.V145G|BAT1_uc011dno.1_Missense_Mutation_p.V98G|BAT1_uc011dnp.1_Missense_Mutation_p.V67G|SNORD117_uc003nty.1_5'Flank|BAT1_uc011dnq.1_RNA	NM_004640	NP_004631	Q13838	DX39B_HUMAN	HLA-B associated transcript 1	145	Helicase ATP-binding.				intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding				0						AAAAACAGCAACCTGCCGAGC	0.498		NA											8	50					0	0	0	0
PRIM2	5558	broad.mit.edu	37	6	57512605	57512605	+	Missense_Mutation	SNP	A	A	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:57512605A>C	uc003pdx.2	+	15	1520	c.1433A>C	c.(1432-1434)CAG>CCG	p.Q478P		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	478					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		CCAAGTGTCCAGAAAACCAAG	0.398		NA											44	429					0	0	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62604557	62604557	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:62604557C>A	uc003peg.2	-	6	1040	c.793G>T	c.(793-795)GAA>TAA	p.E265*		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TCATAAGCTTCATGGGCTGGA	0.478		NA											19	63					6.45e-10	1.33e-09	1	0
IRAK1BP1	134728	broad.mit.edu	37	6	79607895	79607895	+	Silent	SNP	A	A	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:79607895A>G	uc003pim.2	+	4	732	c.627A>G	c.(625-627)AAA>AAG	p.K209K	IRAK1BP1_uc010kbg.1_Intron|IRAK1BP1_uc003pin.2_Silent_p.K122K	NM_001010844	NP_001010844	Q5VVH5	IKBP1_HUMAN	interleukin-1 receptor-associated kinase 1	209					I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus					0		all_cancers(76;0.0398)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)		BRCA - Breast invasive adenocarcinoma(397;0.21)		AAGAAACAAAAGAATGGGAAG	0.388		NA											10	18					0	0	0	0
DOPEY1	23033	broad.mit.edu	37	6	83838721	83838721	+	Missense_Mutation	SNP	G	G	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:83838721G>T	uc003pjs.1	+	16	2095	c.1835G>T	c.(1834-1836)CGA>CTA	p.R612L	DOPEY1_uc011dyy.1_Missense_Mutation_p.R603L|DOPEY1_uc010kbl.1_Missense_Mutation_p.R603L	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	612					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		CAAGCAGACCGAACTGATGAT	0.458		NA											39	110					5.45e-19	1.14e-18	1	0
ASCC3	10973	broad.mit.edu	37	6	101054640	101054640	+	Missense_Mutation	SNP	G	G	A	rs112466876		TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:101054640G>A	uc003pqk.2	-	32	5349	c.5020C>T	c.(5020-5022)CGT>TGT	p.R1674C		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1674	Helicase C-terminal 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TCCACATAACGTCTTGTTTTT	0.308		NA											23	63					0	0	0	0
FAM54A	113115	broad.mit.edu	37	6	136562633	136562633	+	Missense_Mutation	SNP	G	G	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:136562633G>C	uc010kgp.1	-	5	853	c.463C>G	c.(463-465)CAG>GAG	p.Q155E	FAM54A_uc003qgt.1_Missense_Mutation_p.Q155E|FAM54A_uc003qgu.1_Missense_Mutation_p.Q112E	NM_001099286	NP_001092756	Q6P444	FA54A_HUMAN	DUF729 domain containing 1	155										skin(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00228)|OV - Ovarian serous cystadenocarcinoma(155;0.00504)		GCTGCAATCTGAGAGCGAAGA	0.343		NA											5	40					0	0	0	0
FERD3L	222894	broad.mit.edu	37	7	19184751	19184751	+	Missense_Mutation	SNP	C	C	T	rs71017023		TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:19184751C>T	uc003suo.1	-	1	294	c.235G>A	c.(235-237)GAA>AAA	p.E79K	uc003sun.1_RNA	NM_152898	NP_690862	Q96RJ6	FER3L_HUMAN	nephew of atonal 3	79	Poly-Glu.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			large_intestine(1)	1						cgctcctcttcctcctcctct	0.363		NA											11	19					0	0	0	0
BBS9	27241	broad.mit.edu	37	7	33573768	33573768	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:33573768C>T	uc003tdn.1	+	21	3014	c.2501C>T	c.(2500-2502)CCA>CTA	p.P834L	BBS9_uc003tdo.1_Missense_Mutation_p.P799L|BBS9_uc003tdp.1_Missense_Mutation_p.P829L|BBS9_uc003tdq.1_Missense_Mutation_p.P794L|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Missense_Mutation_p.P358L|BBS9_uc003tds.1_Missense_Mutation_p.P257L|BBS9_uc003tdt.2_RNA	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	834					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			GCAGCAGCCCCACAGACCATG	0.478		NA							Bardet-Biedl_syndrome				11	40					0	0	0	0
IKZF1	10320	broad.mit.edu	37	7	50467751	50467751	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:50467751C>T	uc003tow.3	+	9	1154	c.986C>T	c.(985-987)CCG>CTG	p.P329L	IKZF1_uc003tox.3_Missense_Mutation_p.P287L|IKZF1_uc003toy.3_Missense_Mutation_p.P287L|IKZF1_uc011kck.1_Missense_Mutation_p.P242L|IKZF1_uc003toz.3_Missense_Mutation_p.P299L|IKZF1_uc010kyx.2_Missense_Mutation_p.P69L|IKZF1_uc003tpa.3_Missense_Mutation_p.P71L	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	329					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding			haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				TCCCTGCGCCCGCTGGTGCAG	0.652		NA	D		ALL								10	11					0	0	0	0
DDC	1644	broad.mit.edu	37	7	50534959	50534959	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:50534959C>A	uc003tpf.3	-	13	1281	c.1195G>T	c.(1195-1197)GAA>TAA	p.E399*	DDC_uc010kza.2_Nonsense_Mutation_p.E314*|DDC_uc003tpg.3_Nonsense_Mutation_p.E399*	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	399					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	ACACAGATTTCAAAGCGGGGA	0.448		NA											42	126					6.53e-18	1.37e-17	1	0
ZNF679	168417	broad.mit.edu	37	7	63720697	63720697	+	Silent	SNP	A	A	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:63720697A>G	uc003tsx.2	+	3	407	c.138A>G	c.(136-138)TTA>TTG	p.L46L		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	46	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						ATGTGATGTTAGAGAACTACA	0.378		NA											3	74					0	0	0	0
ZAN	7455	broad.mit.edu	37	7	100349865	100349865	+	Missense_Mutation	SNP	T	T	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:100349865T>C	uc003uwj.2	+	14	2302	c.2137T>C	c.(2137-2139)TCC>CCC	p.S713P	ZAN_uc003uwk.2_Missense_Mutation_p.S713P|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	713	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACCCACCATCTCCCCAGAAAA	0.502		NA											5	111					0	0	0	0
LAMB1	3912	broad.mit.edu	37	7	107613482	107613482	+	Missense_Mutation	SNP	C	C	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:107613482C>A	uc003vew.2	-	13	1852	c.1517G>T	c.(1516-1518)GGA>GTA	p.G506V	LAMB1_uc003vev.2_Missense_Mutation_p.G530V|LAMB1_uc003vex.2_Missense_Mutation_p.G506V|LAMB1_uc010ljn.1_Missense_Mutation_p.G592V	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	506	Laminin EGF-like 4.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGGTCGACATCCATCCAAATC	0.458		NA											32	56					2.42e-17	5.03e-17	1	0
C7orf60	154743	broad.mit.edu	37	7	112472713	112472713	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:112472713C>T	uc003vgo.1	-	4	618	c.491G>A	c.(490-492)GGA>GAA	p.G164E	C7orf60_uc011kms.1_Missense_Mutation_p.G190E	NM_152556	NP_689769	Q1RMZ1	CG060_HUMAN	hypothetical protein LOC154743	164										ovary(2)|skin(1)	3						TCTGATTTTTCCTGAGGCTTG	0.294		NA											6	60					0	0	0	0
CA1	759	broad.mit.edu	37	8	86244757	86244757	+	Missense_Mutation	SNP	G	G	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr8:86244757G>T	uc003ydh.2	-	7	675	c.475C>A	c.(475-477)CAG>AAG	p.Q159K	CA13_uc003ydf.1_Intron|CA1_uc010mae.1_Missense_Mutation_p.Q159K|CA1_uc003ydi.2_Missense_Mutation_p.Q159K	NM_001738	NP_001729	P00915	CAH1_HUMAN	carbonic anhydrase I	159					one-carbon metabolic process	Golgi apparatus	carbonate dehydratase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(136;4.89e-06)			Acetazolamide(DB00819)|Amlodipine(DB00381)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dichlorphenamide(DB01144)|Ethinamate(DB01031)|Ethoxzolamide(DB00311)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Levetiracetam(DB01202)|Methazolamide(DB00703)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)|Verapamil(DB00661)|Zonisamide(DB00909)	AGTACTTTCTGCAGCTTTGGG	0.328		NA											13	31					7.93e-07	1.62e-06	1	0
VPS13B	157680	broad.mit.edu	37	8	100147948	100147948	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr8:100147948C>T	uc003yiv.2	+	11	1661	c.1550C>T	c.(1549-1551)TCA>TTA	p.S517L	VPS13B_uc003yiw.2_Missense_Mutation_p.S517L|VPS13B_uc003yit.2_Missense_Mutation_p.S517L|VPS13B_uc003yiu.1_Missense_Mutation_p.S517L|VPS13B_uc003yix.1_5'Flank	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	517					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ATCTTGGATTCAACTCATCAT	0.348		NA											6	42					0	0	0	0
DPYS	1807	broad.mit.edu	37	8	105463606	105463606	+	Missense_Mutation	SNP	C	C	T	rs148513732	by1000genomes	TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr8:105463606C>T	uc003yly.3	-	2	420	c.291G>A	c.(289-291)ATG>ATA	p.M97I		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	97					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AATCAATAATCATGGTGGTGC	0.458		NA											43	47					0	0	0	0
WISP1	8840	broad.mit.edu	37	8	134233036	134233036	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr8:134233036G>A	uc003yub.2	+	3	638	c.562G>A	c.(562-564)GAC>AAC	p.D188N	WISP1_uc003yuc.2_Intron|WISP1_uc010meb.2_Intron|WISP1_uc010mec.2_Intron|WISP1_uc010med.2_Intron|WISP1_uc003yud.2_Intron	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	188					cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			ATGTGAGGACGACGCCAAGAG	0.682		NA											18	86					0	0	0	0
MOBKL2B	79817	broad.mit.edu	37	9	27455464	27455464	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:27455464C>T	uc003zqn.2	-	2	581	c.85G>A	c.(85-87)GAG>AAG	p.E29K		NM_024761	NP_079037	Q86TA1	MOL2B_HUMAN	MOB1, Mps One Binder kinase activator-like 2B	29							metal ion binding|protein binding			ovary(1)|pleura(1)	2		all_neural(11;9.12e-11)		Lung(218;6.54e-05)|LUSC - Lung squamous cell carcinoma(38;0.000397)		TTGTGCAGCTCAAACCTCTGT	0.552		NA											42	159					0	0	0	0
NDUFB6	4712	broad.mit.edu	37	9	32558937	32558937	+	Missense_Mutation	SNP	T	T	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:32558937T>C	uc003zre.1	-	3	413	c.289A>G	c.(289-291)ATA>GTA	p.I97V	NDUFB6_uc003zrf.1_Intron	NM_002493	NP_002484	O95139	NDUB6_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	97					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00199)	NADH(DB00157)	TTTTCAACTATGCCATATGGT	0.224		NA											32	115					0	0	0	0
MELK	9833	broad.mit.edu	37	9	36599430	36599430	+	Silent	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:36599430C>T	uc003zzn.2	+	7	652	c.514C>T	c.(514-516)CTG>TTG	p.L172L	MELK_uc011lpm.1_Silent_p.L41L|MELK_uc011lpn.1_Silent_p.L172L|MELK_uc011lpo.1_5'UTR|MELK_uc010mll.2_Silent_p.L140L|MELK_uc011lpp.1_Silent_p.L124L|MELK_uc010mlm.2_Silent_p.L101L|MELK_uc011lpq.1_5'UTR|MELK_uc011lpr.1_Silent_p.L101L|MELK_uc011lps.1_Silent_p.L92L	NM_014791	NP_055606	Q14680	MELK_HUMAN	maternal embryonic leucine zipper kinase	172	Protein kinase.					cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)			CTGTGGGAGTCTGGCTTATGC	0.299		NA											14	32					0	0	0	0
C9orf71	169693	broad.mit.edu	37	9	71155642	71155642	+	Missense_Mutation	SNP	C	C	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:71155642C>G	uc004agt.2	-	1	142	c.89G>C	c.(88-90)TGG>TCG	p.W30S		NM_153237	NP_694969	Q8N6L7	CI071_HUMAN	hypothetical protein LOC169693	30						integral to membrane					0						TATGGAGCCCCAGGAAATGAA	0.522		NA											20	42					0	0	0	0
APBA1	320	broad.mit.edu	37	9	72131514	72131514	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:72131514G>A	uc004ahh.2	-	2	889	c.613C>T	c.(613-615)CCC>TCC	p.P205S		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	205					axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						TCCAGCTCGGGCGCGTCCCCT	0.716		NA											7	28					0	0	0	0
LPAR1	1902	broad.mit.edu	37	9	113637831	113637831	+	Missense_Mutation	SNP	A	A	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:113637831A>G	uc004bfa.2	-	5	1220	c.965T>C	c.(964-966)TTT>TCT	p.F322S	LPAR1_uc011lwm.1_Missense_Mutation_p.F323S|LPAR1_uc004bfb.2_Missense_Mutation_p.F322S|LPAR1_uc004bfc.2_Missense_Mutation_p.F322S|LPAR1_uc011lwn.1_Missense_Mutation_p.F304S|LPAR1_uc011lwo.1_Missense_Mutation_p.F323S|LPAR1_uc010mub.2_Missense_Mutation_p.F322S	NM_057159	NP_476500	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	322	Cytoplasmic (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				ovary(2)	2						GATCTGCCTAAAGGTGGCGCT	0.552		NA											4	141					0	0	0	0
HSPA5	3309	broad.mit.edu	37	9	128003180	128003180	+	Silent	SNP	G	G	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:128003180G>C	uc004bpn.2	-	2	385	c.129C>G	c.(127-129)GGC>GGG	p.G43G		NM_005347	NP_005338	P11021	GRP78_HUMAN	heat shock 70kDa protein 5	43					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			ovary(3)|skin(1)	4					Antihemophilic Factor(DB00025)	TCTTGAACACGCCGACGCTGG	0.632		NA								Prostate(1;0.17)			9	114					0	0	0	0
ODF2	4957	broad.mit.edu	37	9	131221882	131221882	+	Silent	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:131221882C>T	uc011mbd.1	+	3	380	c.69C>T	c.(67-69)CTC>CTT	p.L23L	ODF2_uc011maz.1_Silent_p.L23L|ODF2_uc011mba.1_5'UTR|ODF2_uc010myb.2_5'UTR|ODF2_uc011mbb.1_5'UTR|ODF2_uc011mbc.1_5'UTR|ODF2_uc004bva.2_5'UTR|ODF2_uc004bvb.2_5'UTR|ODF2_uc011mbe.1_5'UTR|ODF2_uc004bvc.2_5'UTR|ODF2_uc010myc.2_Silent_p.L23L|ODF2_uc011mbf.1_Silent_p.L23L|ODF2_uc004bvd.3_Silent_p.L23L|ODF2_uc004bve.2_Silent_p.L23L	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	23					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						TAACGAGTCTCACGCAGAAAA	0.493		NA											9	22					0	0	0	0
BAT2L1	84726	broad.mit.edu	37	9	134308054	134308054	+	Missense_Mutation	SNP	C	C	T			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:134308054C>T	uc004can.3	+	2	221	c.166C>T	c.(166-168)CGC>TGC	p.R56C	BAT2L1_uc004cam.1_Missense_Mutation_p.R56C	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	56							protein binding				0						TGCAGCCCGGCGCATGCCACC	0.527		NA											34	33					0	0	0	0
SURF4	6836	broad.mit.edu	37	9	136234196	136234196	+	Silent	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:136234196G>A	uc004cdj.2	-	2	304	c.174C>T	c.(172-174)ACC>ACT	p.T58T	SURF4_uc011mda.1_Silent_p.T49T|SURF4_uc010nal.2_Silent_p.T90T|SURF4_uc011mdb.1_Silent_p.T15T|SURF4_uc011mdc.1_Silent_p.T15T|SURF4_uc011mdd.1_Silent_p.T58T	NM_033161	NP_149351	O15260	SURF4_HUMAN	surfeit 4	58						endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;5.32e-07)|Epithelial(140;4.56e-06)|all cancers(34;4.25e-05)		CGCAGTTCCAGGTGGTGTCGA	0.617		NA											25	64					0	0	0	0
ZCCHC18	644353	broad.mit.edu	37	X	103359010	103359010	+	Missense_Mutation	SNP	G	G	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chrX:103359010G>C	uc011msh.1	+	3	1524	c.208G>C	c.(208-210)GAG>CAG	p.E70Q	MCART6_uc004elu.2_Intron|ZCCHC18_uc011msg.1_Intron	NM_001143978	NP_001137450	P0CG32	ZCC18_HUMAN	zinc finger, CCHC domain containing 18	70							nucleic acid binding|zinc ion binding				0						CCAAGTCAATGAGGTCCTGCC	0.502		NA											7	8					0	0	0	0
PSMD10	5716	broad.mit.edu	37	X	107331314	107331314	+	Missense_Mutation	SNP	G	G	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chrX:107331314G>A	uc004enp.1	-	3	327	c.229C>T	c.(229-231)CTT>TTT	p.L77F	PSMD10_uc004enq.1_Missense_Mutation_p.L77F|PSMD10_uc010nph.1_Intron	NM_002814	NP_002805	O75832	PSD10_HUMAN	proteasome 26S non-ATPase subunit 10 isoform 1	77	Interaction with RELA.|ANK 3.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cytoplasmic sequestering of NF-kappaB|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of MAPKKK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of release of cytochrome c from mitochondria|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus|proteasome regulatory particle	transcription factor binding			ovary(1)	1						GCAATATGAAGAGGAGACCAA	0.453		NA											16	27					0	0	0	0
CXorf56	63932	broad.mit.edu	37	X	118673707	118673707	+	Missense_Mutation	SNP	C	C	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chrX:118673707C>G	uc004erk.1	-	7	698	c.652G>C	c.(652-654)GAC>CAC	p.D218H	uc004eri.2_5'Flank|CXorf56_uc004erj.1_Missense_Mutation_p.D169H|CXorf56_uc011mtu.1_Missense_Mutation_p.D204H	NM_022101	NP_071384	Q9H5V9	CX056_HUMAN	hypothetical protein LOC63932	218	Potential.						protein binding				0						AACTGGTTGTCAATCAAGGTC	0.373		NA											9	11					0	0	0	0
CNGA2	1260	broad.mit.edu	37	X	150912370	150912370	+	Missense_Mutation	SNP	G	G	C			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chrX:150912370G>C	uc004fey.1	+	7	1619	c.1395G>C	c.(1393-1395)GAG>GAC	p.E465D		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	465	Helical; Name=H6; (Potential).|cAMP (By similarity).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGCTGGTAGAGCTGGTACTGA	0.408		NA											19	30					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105419961	105419962	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr14:105419961_105419962delTG	uc010axc.1	-	7	1946_1947	c.1826_1827delCA	c.(1825-1827)ACAfs	p.T609fs	AHNAK2_uc001ypx.2_Frame_Shift_Del_p.T509fs	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	609						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TTCCCTGCTCTGTGTCTTCTGT	0.475		NA											10	613	---	---	---	---	NA	NA	NA	NA
ASXL3	80816	broad.mit.edu	37	18	31319985	31319986	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr18:31319985_31319986insA	uc010dmg.1	+	11	2672_2673	c.2617_2618insA	c.(2617-2619)GAAfs	p.E873fs	ASXL3_uc002kxq.2_Frame_Shift_Ins_p.E580fs	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	873					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GCAAAGAACAGAAAAAAAAGTG	0.376		NA											31	39	---	---	---	---	NA	NA	NA	NA
ACSS1	84532	broad.mit.edu	37	20	25038539	25038567	+	Frame_Shift_Del	DEL	CGGGCTGCCTGTGCACTCAGCGCGGGATA	CGGGCTGCCTGTGCACTCAGCGCGGGATA	-	rs73348757	by1000genomes	TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr20:25038539_25038567delCGGGCTGCCTGTGCACTCAGCGCGGGATA	uc002wub.2	-	1	1050_1078	c.172_200delTATCCCGCGCTGAGTGCACAGGCAGCCCG	c.(172-201)TATCCCGCGCTGAGTGCACAGGCAGCCCGGfs	p.Y58fs	ACSS1_uc002wuc.2_Frame_Shift_Del_p.Y58fs|ACSS1_uc010gdc.2_Frame_Shift_Del_p.Y58fs	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	58_67					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GGCCGGCTCCCGGGCTGCCTGTGCACTCAGCGCGGGATACGAGCCTGGC	0.734		NA											12	34	---	---	---	---	NA	NA	NA	NA
POU4F2	5458	broad.mit.edu	37	4	147560457	147560458	+	In_Frame_Ins	INS	-	-	GGC	rs67907220		TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr4:147560457_147560458insGGC	uc003ikv.2	+	1	413_414	c.165_166insGGC	c.(163-168)insGGC	p.68_69insG		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	68_69					estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					ACGCTggtggtggcggcggcgg	0.386		NA											6	7	---	---	---	---	NA	NA	NA	NA
POM121L12	285877	broad.mit.edu	37	7	53104149	53104149	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:53104149delC	uc003tpz.2	+	1	801	c.785delC	c.(784-786)TCCfs	p.S262fs		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	262											0						CCCGCCCCATCCGCCATCTGG	0.657		NA											40	74	---	---	---	---	NA	NA	NA	NA
MLL5	55904	broad.mit.edu	37	7	104751259	104751259	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:104751259delT	uc003vcm.2	+	26	4546	c.4012delT	c.(4012-4014)TGTfs	p.C1338fs	MLL5_uc010ljc.2_Frame_Shift_Del_p.C1338fs|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Frame_Shift_Del_p.C72fs|uc003vcp.1_5'Flank|MLL5_uc010ljh.1_Frame_Shift_Del_p.N101fs	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1338					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						TACGAATGAATGTCCATCCCC	0.358		NA											55	103	---	---	---	---	NA	NA	NA	NA
BHLHE22	27319	broad.mit.edu	37	8	65493617	65493618	+	In_Frame_Ins	INS	-	-	GGC			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr8:65493617_65493618insGGC	uc003xvi.2	+	1	804_805	c.270_271insGGC	c.(268-273)insGGC	p.97_98insG	LOC401463_uc003xvh.2_Intron	NM_152414	NP_689627	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix domain containing, class	97_98	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						gcgcgggaagtggcggcggcgg	0.584		NA											6	1	---	---	---	---	NA	NA	NA	NA
PSIP1	11168	broad.mit.edu	37	9	15469032	15469033	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:15469032_15469033insG	uc003zlv.3	-	13	1458_1459	c.1128_1129insC	c.(1126-1131)GCCTTGfs	p.A376fs	PSIP1_uc003zlw.3_Frame_Shift_Ins_p.A376fs	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	376_377	Potential.				initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		AGTTCATCCAAGGCCTCAATGC	0.361		NA											17	24	---	---	---	---	NA	NA	NA	NA
