Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC43A1	8501	broad.mit.edu	37	11	57256464	57256464	+	Splice_Site	SNP	T	T	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:57256464T>A	ENST00000278426.3	-	13	1691		c.e13-2		SLC43A1_ENST00000528450.1_Splice_Site	NM_003627.5	NP_003618.1	O75387	LAT3_HUMAN	solute carrier family 43 (amino acid system L transporter), member 1						cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19						GGTCACAAACTAAAACCAAAA	0.532000													7	144					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10543475	10543475	+	Silent	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:10543475G>A	ENST00000583535.1	-	22	2607	c.2520C>T	c.(2518-2520)ctC>ctT	p.L840L	MYH3_ENST00000226209.7_Silent_p.L840L	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	840					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						CACTCTTGAGGAGGGGCTTGA	0.473000													24	215					0	0	1	0	0
ZNF532	55205	broad.mit.edu	37	18	56586710	56586710	+	Silent	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr18:56586710G>A	ENST00000336078.4	+	4	1967	c.1191G>A	c.(1189-1191)gcG>gcA	p.A397A	ZNF532_ENST00000589288.1_Silent_p.A397A|ZNF532_ENST00000591083.1_Silent_p.A397A|ZNF532_ENST00000591808.1_Silent_p.A397A|ZNF532_ENST00000591230.1_Silent_p.A397A	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	397					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						AGCAGACAGCGTCCGTGATGG	0.552000													3	139					0	0	1	0	0
C9orf116	138162	broad.mit.edu	37	9	138387324	138387324	+	Silent	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr9:138387324C>T	ENST00000429260.2	-	3	380	c.360G>A	c.(358-360)cgG>cgA	p.R120R	C9orf116_ENST00000371789.3_3'UTR|C9orf116_ENST00000371791.1_3'UTR	NM_001048265.1|NM_144654.2	NP_001041730.1|NP_653255.1	Q5BN46	CI116_HUMAN	chromosome 9 open reading frame 116	120															OV - Ovarian serous cystadenocarcinoma(145;7.39e-08)|Epithelial(140;5.19e-07)|all cancers(34;1.04e-05)		GGAAGTTGAGCCGGTCACAGG	0.542000													3	59					0	0	1	0	0
ANP32A	8125	broad.mit.edu	37	15	69080254	69080254	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr15:69080254T>C	ENST00000465139.2	-	2	202	c.59A>G	c.(58-60)aAa>aGa	p.K20R	ANP32A_ENST00000560303.1_Missense_Mutation_p.K20R|ANP32A_ENST00000483551.2_5'UTR	NM_006305.3	NP_006296.1	P39687	AN32A_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	20					intracellular signal transduction|mRNA metabolic process|nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleoplasm|perinuclear region of cytoplasm	protein binding			endometrium(1)|large_intestine(1)|lung(2)	4						GACAAGTTCTTTCACCTGAAA	0.522000													3	187					0	0	1	0	0
LRRCC1	85444	broad.mit.edu	37	8	86038966	86038966	+	Missense_Mutation	SNP	A	A	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr8:86038966A>G	ENST00000414626.2	+	8	2144	c.1255A>G	c.(1255-1257)Aga>Gga	p.R419G	LRRCC1_ENST00000360375.3_Missense_Mutation_p.R439G			Q9C099	LRCC1_HUMAN	leucine rich repeat and coiled-coil centrosomal protein 1	439					cell division|mitosis	centriole|nucleus				breast(3)|central_nervous_system(1)|endometrium(4)|kidney(9)|large_intestine(7)|lung(16)|skin(1)|upper_aerodigestive_tract(2)	43						GAAGAGATGGAGAGCTGAGCA	0.388000													3	73					0	0	1	0	0
CCDC91	55297	broad.mit.edu	37	12	28458580	28458580	+	Splice_Site	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:28458580A>T	ENST00000545336.1	+	7	528		c.e7-1		CCDC91_ENST00000381259.1_Splice_Site|CCDC91_ENST00000539107.1_Splice_Site|CCDC91_ENST00000306172.5_Splice_Site|CCDC91_ENST00000540401.1_Splice_Site|CCDC91_ENST00000381256.1_Splice_Site			Q7Z6B0	CCD91_HUMAN	coiled-coil domain containing 91						protein transport	Golgi apparatus|membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|skin(1)	22	Acute lymphoblastic leukemia(23;0.00718)|all_hematologic(23;0.0113)|Lung SC(9;0.184)					GTTTTTCTTTAGTATCTGGAG	0.393000													10	696					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	116925316	116925316	+	Splice_Site	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:116925316A>T	ENST00000355044.3	+	7	1130		c.e7-1		ATRNL1_ENST00000527407.1_Intron|ATRNL1_ENST00000529665.1_Splice_Site	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1							integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TCTTGCTTTTAGTTACAATTT	0.328000													8	250					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11485944	11485944	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr7:11485944A>T	ENST00000423059.3	-	13	3059	c.2808T>A	c.(2806-2808)agT>agA	p.S936R	AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	936	TSP type-1 9.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CCTTCTTTTTACTTTTTCCTG	0.338000										HNSCC(18;0.044)			6	564					0	0	1	0	0
ARPC2	10109	broad.mit.edu	37	2	219099073	219099073	+	Splice_Site	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:219099073A>T	ENST00000295685.10	+	4	483		c.e4-1		ARPC2_ENST00000315717.5_Splice_Site	NM_005731.2	NP_005722.1	O15144	ARPC2_HUMAN	actin related protein 2/3 complex, subunit 2, 34kDa						cellular component movement	Arp2/3 protein complex|cell projection|Golgi apparatus	actin binding|structural constituent of cytoskeleton			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)	6		Renal(207;0.0474)		Epithelial(149;1.21e-06)|all cancers(144;0.000212)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0103)		TTTATTTTCTAGTTATTAAAG	0.363000													4	161					0	0	1	0	0
NMT2	9397	broad.mit.edu	37	10	15174860	15174860	+	Silent	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:15174860G>A	ENST00000378165.4	-	6	755	c.675C>T	c.(673-675)gtC>gtT	p.V225V	NMT2_ENST00000378150.1_Silent_p.V212V|NMT2_ENST00000535341.1_Silent_p.V212V|NMT2_ENST00000540259.1_Silent_p.V37V|RPP38_ENST00000451677.1_Intron	NM_004808.2	NP_004799.1	O60551	NMT2_HUMAN	N-myristoyltransferase 2	225					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			breast(3)|endometrium(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(1)|upper_aerodigestive_tract(3)	21						TTATGAACCCGACCAGTTTTT	0.458000													3	196					0	0	1	0	0
IL1B	3553	broad.mit.edu	37	2	113591112	113591112	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:113591112C>T	ENST00000263341.2	-	4	350	c.140G>A	c.(139-141)gGc>gAc	p.G47D	IL1B_ENST00000491056.1_5'UTR	NM_000576.2	NP_000567.1	P01584	IL1B_HUMAN	interleukin 1, beta	47					activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding			breast(2)|central_nervous_system(1)|large_intestine(1)|lung(8)	12					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	TAGCTGGATGCCGCCATCCAG	0.612000													4	311					0	0	1	0	0
NXF5	55998	broad.mit.edu	37	X	101095848	101095848	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chrX:101095848C>A	ENST00000537026.1	-	9	859	c.500G>T	c.(499-501)tGc>tTc	p.C167F	NXF5_ENST00000473265.2_Missense_Mutation_p.C167F|NXF5_ENST00000361708.2_Missense_Mutation_p.C167F	NM_032946.2	NP_116564.2	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	167					mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|skin(1)	30						TTTGTTGTTGCACAAGTTCAA	0.483000													110	143					5.63745e-77	6.03727e-77	1	1	0
CNPPD1	27013	broad.mit.edu	37	2	220040313	220040313	+	Splice_Site	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:220040313C>T	ENST00000409789.1	-	4	687	c.260_splice	c.e4+1	p.R87_splice	CNPPD1_ENST00000360507.5_Splice_Site_p.R87_splice			Q9BV87	CNPD1_HUMAN	cyclin Pas1/PHO80 domain containing 1	87					regulation of cyclin-dependent protein kinase activity	integral to membrane	protein kinase binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)	12						CCAGGCTCACCGGGACACATG	0.463000													3	188					0	0	1	0	0
SPZ1	84654	broad.mit.edu	37	5	79616605	79616605	+	Missense_Mutation	SNP	C	C	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:79616605C>G	ENST00000296739.4	+	1	816	c.571C>G	c.(571-573)Cag>Gag	p.Q191E		NM_032567.3	NP_115956.3	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			endometrium(2)|kidney(5)|large_intestine(4)|lung(12)|ovary(1)|skin(2)	26		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		AAAGAAACAGCAGATGATAAT	0.353000													5	198					0	0	1	0	0
SPRED3	399473	broad.mit.edu	37	19	38881011	38881011	+	Silent	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:38881011C>T	ENST00000338502.4	+	1	172	c.69C>T	c.(67-69)ggC>ggT	p.G23G	SPRED3_ENST00000587564.2_3'UTR|SPRED3_ENST00000587013.1_Intron|SPRED3_ENST00000586301.1_Silent_p.G23G	NM_001042522.1	NP_001035987.1	Q2MJR0	SPRE3_HUMAN	sprouty-related, EVH1 domain containing 3	23	WH1.				multicellular organismal development					central_nervous_system(2)|large_intestine(1)|lung(5)|skin(1)	9	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CTGTGGGGGGCGGGGGCCTCA	0.726000													4	41					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025366	207025366	+	Silent	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:207025366G>A	ENST00000392222.2	+	2	510	c.135G>A	c.(133-135)ccG>ccA	p.P45P	EEF1B2_ENST00000392221.1_Silent_p.P45P|EEF1B2_ENST00000236957.5_Silent_p.P45P	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	45	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.P45P(5)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						CCAGCCCACCGCCTGCCGACT	0.448000													3	39					0	0	1	0	0
WDR3	10885	broad.mit.edu	37	1	118493455	118493455	+	Splice_Site	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:118493455A>T	ENST00000349139.4	+	16	1793		c.e16-1			NM_006784.2	NP_006775.1	Q9UNX4	WDR3_HUMAN	WD repeat domain 3							nuclear membrane|nucleolus				breast(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(9)|liver(2)|lung(22)|prostate(2)|upper_aerodigestive_tract(1)	49	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		TTTGATGTTTAGTTTTTTCTG	0.269000													7	119					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179449496	179449496	+	Silent	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:179449496C>T	ENST00000589042.1	-	310	65096	c.64872G>A	c.(64870-64872)ctG>ctA	p.L21624L	TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000359218.5_Silent_p.L12684L|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000342992.6_Silent_p.L19056L|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000591111.1_Silent_p.L19983L|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Silent_p.L12751L|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.L12559L|TTN-AS1_ENST00000589907.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19983	Fibronectin type-III 57.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCCTGGGATCAGCTTTCCAA	0.498000													5	391					0	0	1	0	0
ZNF709	163051	broad.mit.edu	37	19	12575380	12575380	+	Silent	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:12575380C>T	ENST00000397732.3	-	4	1527	c.1356G>A	c.(1354-1356)caG>caA	p.Q452Q	ZNF709_ENST00000428311.1_Silent_p.Q452Q|CTD-3105H18.18_ENST00000598753.1_Intron	NM_152601.3	NP_689814.1	Q8N972	ZN709_HUMAN	zinc finger protein 709	452					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(3)|upper_aerodigestive_tract(3)	6						CTTTACCACACTGTTTACATT	0.403000													4	354					0	0	1	0	0
WARS2	10352	broad.mit.edu	37	1	119576009	119576009	+	Missense_Mutation	SNP	T	T	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:119576009T>A	ENST00000369426.5	-	6	640	c.637A>T	c.(637-639)Atg>Ttg	p.M213L	WARS2_ENST00000537870.1_Intron|WARS2_ENST00000235521.4_Intron			Q9UGM6	SYWM_HUMAN	tryptophanyl tRNA synthetase 2, mitochondrial	0					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(2)	15	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	AACACACACATACCCAAAACA	0.393000													6	305					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55872537	55872537	+	Missense_Mutation	SNP	A	A	G	rs61746549	byFrequency	TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:55872537A>G	ENST00000313503.1	+	1	19	c.19A>G	c.(19-21)Aac>Gac	p.N7D		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.N7D(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					TAGAAGGAATAACACAAATGT	0.438000										HNSCC(53;0.14)			6	665					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420617	55420617	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:55420617G>A	ENST00000242994.3	+	2	772	c.394G>A	c.(394-396)Gcc>Acc	p.A132T		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	132	Helix-loop-helix motif.				amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.A132T(1)		breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						TCTTAGACTGGCCAGGAACTA	0.502000													4	293					0	0	1	0	0
UBXN2B	137886	broad.mit.edu	37	8	59359995	59359995	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr8:59359995C>T	ENST00000399598.2	+	8	1003	c.881C>T	c.(880-882)gCg>gTg	p.A294V		NM_001077619.1	NP_001071087.1	Q14CS0	UBX2B_HUMAN	UBX domain protein 2B	294	UBX.					cytosol|endoplasmic reticulum|Golgi apparatus|nucleus				endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	13						CCTGAATTTGCGGCTCTTGAC	0.348000													3	193					0	0	1	0	0
ECSIT	51295	broad.mit.edu	37	19	11617057	11617057	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:11617057G>A	ENST00000270517.7	-	8	1373	c.1238C>T	c.(1237-1239)cCc>cTc	p.P413L	ECSIT_ENST00000591104.1_3'UTR|ECSIT_ENST00000588998.1_3'UTR|ECSIT_ENST00000417981.2_Missense_Mutation_p.P199L|ECSIT_ENST00000252440.7_3'UTR	NM_016581.4	NP_057665.2	Q9BQ95	ECSIT_HUMAN	ECSIT signalling integrator	413					innate immune response|regulation of oxidoreductase activity	mitochondrion	oxidoreductase activity, acting on NADH or NADPH|protein binding			kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	11						GTGGTCCTCGGGCAGGGGCGG	0.701000													18	39					0	0	1	0	0
SLC9A7	84679	broad.mit.edu	37	X	46502800	46502800	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chrX:46502800G>A	ENST00000328306.4	-	12	1509	c.1484C>T	c.(1483-1485)gCg>gTg	p.A495V		NM_001257291.1|NM_032591.2	NP_001244220.1|NP_115980.1	Q96T83	SL9A7_HUMAN	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7	495					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			breast(2)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|skin(1)	21						GATGGCCAACGCAAATGCCAT	0.493000													4	108					0	0	1	0	0
SLC4A7	9497	broad.mit.edu	37	3	27427425	27427425	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:27427425A>T	ENST00000295736.5	-	23	3493	c.3423T>A	c.(3421-3423)agT>agA	p.S1141R	SLC4A7_ENST00000435667.2_Missense_Mutation_p.S1026R|SLC4A7_ENST00000445684.1_Missense_Mutation_p.S1137R|SLC4A7_ENST00000428386.1_Missense_Mutation_p.S1017R|SLC4A7_ENST00000425128.2_3'UTR|SLC4A7_ENST00000455077.1_Missense_Mutation_p.S1022R|SLC4A7_ENST00000454389.1_Missense_Mutation_p.S1150R|SLC4A7_ENST00000446700.1_Missense_Mutation_p.S1133R|SLC4A7_ENST00000437179.1_Missense_Mutation_p.S1022R|SLC4A7_ENST00000388777.4_Missense_Mutation_p.S691R|SLC4A7_ENST00000440156.1_Missense_Mutation_p.S1137R	NM_003615.4	NP_003606.3	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 7	1141						apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(9)|ovary(4)|skin(1)	38						tctttttcttactttctGGCA	0.323000													11	274					0	0	1	0	0
ARL13B	200894	broad.mit.edu	37	3	93722591	93722591	+	Silent	SNP	A	A	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:93722591A>G	ENST00000394222.3	+	3	494	c.219A>G	c.(217-219)ggA>ggG	p.G73G	ARL13B_ENST00000535334.1_5'UTR|ARL13B_ENST00000539730.1_Intron|ARL13B_ENST00000471138.1_Silent_p.G73G|ARL13B_ENST00000303097.7_Intron|ARL13B_ENST00000486562.1_Intron	NM_001174150.1	NP_001167621.1	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 13B	73							GTP binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(2)	10						TTGACTTGGGAGGTGGAATAA	0.383000													4	358					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28541173	28541173	+	Silent	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:28541173G>A	ENST00000452236.2	-	4	3110	c.2493C>T	c.(2491-2493)gcC>gcT	p.A831A		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	831					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						ttttagacttggcaaccggaa	0.408000													4	176					0	0	1	0	0
ITGAE	3682	broad.mit.edu	37	17	3661079	3661079	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:3661079C>T	ENST00000263087.4	-	9	1039	c.941G>A	c.(940-942)gGc>gAc	p.G314D		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	314	VWFA.				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		CTCGAATATGCCACCATCGGT	0.547000													7	813					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56817174	56817174	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:56817174C>T	ENST00000229201.4	-	18	2327	c.2173G>A	c.(2173-2175)Gtg>Atg	p.V725M	TIMELESS_ENST00000554616.1_Intron|TIMELESS_ENST00000553532.1_Missense_Mutation_p.V726M	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	726					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						AGCATCTTCACAATGCAATGG	0.498000													4	197					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47103733	47103733	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:47103733A>T	ENST00000409792.3	-	14	6255	c.6213T>A	c.(6211-6213)aaT>aaA	p.N2071K	SETD2_ENST00000492397.1_5'UTR	NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2071					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TTTTCTCTTTATTTTGAGTTT	0.493000			"""N, F, S, Mis"""		clear cell renal carcinoma								7	868					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	116925320	116925320	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:116925320A>T	ENST00000355044.3	+	7	1133	c.1007A>T	c.(1006-1008)tAc>tTc	p.Y336F	ATRNL1_ENST00000527407.1_Intron|ATRNL1_ENST00000529665.1_3'UTR	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	336						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GCTTTTAGTTACAATTTAGAA	0.338000													4	272					0	0	1	0	0
FGD2	221472	broad.mit.edu	37	6	36982762	36982762	+	Missense_Mutation	SNP	T	T	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:36982762T>G	ENST00000274963.8	+	8	1148	c.977T>G	c.(976-978)gTc>gGc	p.V326G		NM_173558.3	NP_775829.2	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	326	PH 1.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	25						GAGGGCCCGGTCCTCAAGATC	0.627000													32	48					0	0	1	0	0
PLA2G4C	8605	broad.mit.edu	37	19	48578024	48578024	+	Splice_Site	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:48578024C>T	ENST00000354276.3	-	12	1333	c.1006_splice	c.e12+1	p.G336_splice	PLA2G4C_ENST00000413144.2_Splice_Site_p.G336_splice|PLA2G4C_ENST00000599921.1_Splice_Site_p.G336_splice|PLA2G4C_ENST00000599111.1_Splice_Site_p.G346_splice	NM_001159323.1	NP_001152795.1	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC (cytosolic, calcium-independent)	336	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(12)|lung(13)|ovary(2)|prostate(1)|skin(3)	38		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		CACATGGTACCTTTCCTTTCG	0.572000													17	658					0	0	1	0	0
OSBPL1A	114876	broad.mit.edu	37	18	21898607	21898607	+	Silent	SNP	G	G	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr18:21898607G>C	ENST00000319481.3	-	9	896	c.690C>G	c.(688-690)gtC>gtG	p.V230V		NM_080597.3	NP_542164.2	Q9BXW6	OSBL1_HUMAN	oxysterol binding protein-like 1A	230					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					CTTTGTAGATGACCTGTCAAA	0.284000													6	41					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104171928	104171928	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:104171928C>T	ENST00000020673.5	-	7	2331	c.1805G>A	c.(1804-1806)gGc>gAc	p.G602D	PSD_ENST00000406432.1_Missense_Mutation_p.G602D	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	602	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		CAGAGTCATGCCCGTGAAGAC	0.587000													4	298					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215597	140215597	+	Silent	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:140215597G>A	ENST00000525929.1	+	1	1629	c.1629G>A	c.(1627-1629)ccG>ccA	p.P543P	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000378125.3_Silent_p.P543P|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGGCGTGCCGCCTCTGGGCA	0.692000													3	131					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100199272	100199272	+	Silent	SNP	G	G	A	rs148546971		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:100199272G>A	ENST00000317233.4	-	16	3016	c.2781C>T	c.(2779-2781)ggC>ggT	p.G927G	AFF3_ENST00000356421.2_Silent_p.G952G|AFF3_ENST00000409579.1_Silent_p.G952G|AFF3_ENST00000409236.1_Silent_p.G927G	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	927					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						TGAGGTCTCCGCCGTGAGGCT	0.488000													6	80					0	0	1	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74506948	74506948	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:74506948A>T	ENST00000354431.4	-	7	1858	c.1667T>A	c.(1666-1668)cTa>cAa	p.L556Q	LRRIQ3_ENST00000395089.1_Missense_Mutation_p.L556Q	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	556										NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						TTCTGCTTTTAGTTTTTGCTT	0.323000													4	99					0	0	1	0	0
CYP2D7	1564	broad.mit.edu	37	22	42538870	42538870	+	RNA	SNP	A	A	C	rs2982057	by1000genomes	TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr22:42538870A>C	ENST00000433992.1	-	0	475				CYP2D7P1_ENST00000424775.1_RNA|CYP2D7P1_ENST00000358097.4_RNA																endometrium(1)	1						CCATAGCGCGACAGGAACACC	0.687000													6	22					0	0	1	0	0
OR8B12	219858	broad.mit.edu	37	11	124412936	124412936	+	Silent	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:124412936G>A	ENST00000306842.2	-	1	639	c.615C>T	c.(613-615)gaC>gaT	p.D205D		NM_001005195.1	NP_001005195.1	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B, member 12	205					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		GCATTCCAACGTCAACAGCCA	0.448000													3	185					0	0	1	0	0
ETV6	2120	broad.mit.edu	37	12	12022525	12022525	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:12022525C>T	ENST00000396373.4	+	5	905	c.631C>T	c.(631-633)Cgc>Tgc	p.R211C		NM_001987.4	NP_001978.1	P41212	ETV6_HUMAN	ets variant 6	211						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/JAK2(11)|ETV6/ITPR2(2)|ETV6/NTRK3(238)	breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(15)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CATGATCCGCCGCCTCTCCCC	0.622000			T	"""NTRK3, RUNX1, PDGFRB, ABL1, MN1, ABL2, FACL6, CHIC2, ARNT, JAK2, EVI1, CDX2, STL, HLXB9, MDS2, PER1, SYK, TTL, FGFR3, PAX5"""	"""congenital fibrosarcoma, multiple leukemia and lymphoma,  secretory breast, MDS, ALL"""								6	103					0	0	1	0	0
SUV420H1	51111	broad.mit.edu	37	11	67925230	67925230	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:67925230T>C	ENST00000304363.4	-	11	2936	c.2583A>G	c.(2581-2583)atA>atG	p.I861M		NM_017635.3	NP_060105.3	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 (Drosophila)	861					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(15)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46						CTTTTCCAACTATTAACCTCA	0.413000													5	75					0	0	1	0	0
ZNF260	339324	broad.mit.edu	37	19	37005601	37005601	+	Silent	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:37005601A>T	ENST00000523638.1	-	3	1661	c.540T>A	c.(538-540)atT>atA	p.I180I	ZNF260_ENST00000593142.1_Silent_p.I180I|ZNF260_ENST00000592282.1_Silent_p.I180I|ZNF260_ENST00000588993.1_Silent_p.I180I	NM_001166036.1|NM_001166037.1|NM_001166038.1	NP_001159508.1|NP_001159509.1|NP_001159510.1	Q3ZCT1	ZN260_HUMAN	zinc finger protein 260	180					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)	15	Esophageal squamous(110;0.162)					TCTGATGTTTAATGAGGTATT	0.388000													7	259					0	0	1	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69034497	69034497	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:69034497T>C	ENST00000295381.3	+	5	975	c.556T>C	c.(556-558)Ttc>Ctc	p.F186L	ARHGAP25_ENST00000456116.2_3'UTR|ARHGAP25_ENST00000409220.1_Missense_Mutation_p.F180L|ARHGAP25_ENST00000409030.3_Missense_Mutation_p.F179L|ARHGAP25_ENST00000497079.1_Missense_Mutation_p.F180L|ARHGAP25_ENST00000409202.3_Missense_Mutation_p.F187L|ARHGAP25_ENST00000467265.1_Missense_Mutation_p.F147L|ARHGAP25_ENST00000544262.1_Missense_Mutation_p.F161L	NM_001007231.2	NP_001007232.2	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	186	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						ATGTGCAGAGTTCATCCTGGA	0.577000													21	244					0	0	1	0	0
CCDC15	80071	broad.mit.edu	37	11	124857652	124857652	+	Silent	SNP	G	G	A	rs111966038		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:124857652G>A	ENST00000529051.1	+	8	1789	c.1530G>A	c.(1528-1530)ttG>ttA	p.L510L	CCDC15_ENST00000344762.5_Silent_p.L510L			Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	510						centrosome				central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(1)	23	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		AGAATTTTTTGTCTAGAGACC	0.388000													5	428					0	0	1	0	0
TNS4	84951	broad.mit.edu	37	17	38633918	38633918	+	Silent	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:38633918C>T	ENST00000254051.6	-	13	2228	c.2070G>A	c.(2068-2070)gcG>gcA	p.A690A		NM_032865.5	NP_116254.4	Q8IZW8	TENS4_HUMAN	tensin 4	690	Phosphatase tensin-type.				apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	30		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			TGTCATACTCCGCAAAGAGGT	0.602000													5	587					0	0	1	0	0
AKAP10	11216	broad.mit.edu	37	17	19861404	19861404	+	Missense_Mutation	SNP	G	G	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:19861404G>T	ENST00000225737.6	-	4	957	c.800C>A	c.(799-801)tCt>tAt	p.S267Y	AKAP10_ENST00000395536.3_Missense_Mutation_p.S267Y	NM_007202.3	NP_009133.2	O43572	AKA10_HUMAN	A kinase (PRKA) anchor protein 10	267	RGS 1.				blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	21	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					TGTAGAGGAAGATTCTTGGGT	0.428000													11	609					3.86212e-05	3.96721e-05	1	1	0
AHI1	54806	broad.mit.edu	37	6	135784297	135784297	+	Silent	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:135784297A>T	ENST00000367800.4	-	6	1113	c.897T>A	c.(895-897)ccT>ccA	p.P299P	AHI1_ENST00000457866.2_Silent_p.P299P|AHI1_ENST00000327035.6_Silent_p.P299P	NM_001134830.1	NP_001128302.1	Q8N157	AHI1_HUMAN	Abelson helper integration site 1	299						adherens junction|cilium|microtubule basal body				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)	37	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		TTTTTGGTTTAGGTTTTGTAT	0.303000													6	149					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	67013849	67013849	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:67013849C>A	ENST00000340001.4	-	21	3060	c.2849G>T	c.(2848-2850)gGc>gTc	p.G950V	ABCA9_ENST00000370732.2_Missense_Mutation_p.G950V|ABCA9_ENST00000453985.2_Missense_Mutation_p.G950V|ABCA9-AS1_ENST00000458677.1_RNA	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	950					transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					GTCATCTGTGCCATTTCTAGT	0.428000													30	1396					3.62473e-10	3.82751e-10	1	1	0
TTC18	118491	broad.mit.edu	37	10	75051106	75051106	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:75051106A>T	ENST00000401621.2	-	20	2447	c.2327T>A	c.(2326-2328)gTa>gAa	p.V776E	TTC18_ENST00000493787.1_5'UTR|TTC18_ENST00000355577.3_Missense_Mutation_p.V245E|TTC18_ENST00000340329.3_Intron|TTC18_ENST00000394865.1_Missense_Mutation_p.V776E|TTC18_ENST00000310715.3_Missense_Mutation_p.V776E			Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	776							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					TTGCTTTGTTACTTGTGCCTG	0.438000													7	704					0	0	1	0	0
SMG8	55181	broad.mit.edu	37	17	57290221	57290221	+	Silent	SNP	T	T	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:57290221T>A	ENST00000543872.2	+	4	2301	c.2037T>A	c.(2035-2037)ctT>ctA	p.L679L	SMG8_ENST00000300917.5_Silent_p.L679L|CTD-2510F5.6_ENST00000577660.1_Intron|SMG8_ENST00000580498.1_3'UTR			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	679					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						CTGATAAACTTAAAGAAAAAG	0.438000													7	304					0	0	1	0	0
SP1	6667	broad.mit.edu	37	12	53777071	53777071	+	Missense_Mutation	SNP	G	G	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:53777071G>T	ENST00000426431.2	+	3	1379	c.1319G>T	c.(1318-1320)gGt>gTt	p.G440V	SP1_ENST00000327443.4_Missense_Mutation_p.G447V	NM_003109.1	NP_003100.1	P08047	SP1_HUMAN	Sp1 transcription factor	447	Transactivation domain B (Gln-rich).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.00527)		CCAAACTCTGGTCCCATCATC	0.552000													13	210					1.05317e-09	1.10437e-09	1	1	0
TFPT	29844	broad.mit.edu	37	19	54610427	54610427	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:54610427G>A	ENST00000391759.1	-	6	1097	c.692C>T	c.(691-693)tCc>tTc	p.S231F	NDUFA3_ENST00000391764.3_Intron|NDUFA3_ENST00000485876.1_3'UTR|TFPT_ENST00000391757.1_3'UTR|TFPT_ENST00000391758.1_Missense_Mutation_p.S222F	NM_013342.3	NP_037474.1	P0C1Z6	TFPT_HUMAN	TCF3 (E2A) fusion partner (in childhood Leukemia)	231					apoptosis|DNA recombination|DNA repair|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex	DNA binding|protein binding			large_intestine(2)|lung(2)	4	all_cancers(19;0.004)|all_epithelial(19;0.00195)|all_lung(19;0.0193)|Lung NSC(19;0.0358)|Breast(117;0.137)|Ovarian(34;0.19)					AACCCAACTGGAATCCAGGGC	0.527000			T	TCF3	pre-B ALL								6	275					0	0	1	0	0
ZNF799	90576	broad.mit.edu	37	19	12501446	12501446	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:12501446T>C	ENST00000419318.1	-	4	2419	c.1670A>G	c.(1669-1671)gAa>gGa	p.E557G	CTD-3105H18.14_ENST00000435033.1_Intron|ZNF799_ENST00000430385.3_Missense_Mutation_p.E589G			Q96GE5	ZN799_HUMAN	zinc finger protein 799	589					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(2)	19						TTCCTTACATTCATACGGGTT	0.413000													6	307					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201039525	201039525	+	Silent	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:201039525G>A	ENST00000362061.3	-	17	2461	c.2235C>T	c.(2233-2235)gaC>gaT	p.D745D	CACNA1S_ENST00000367338.3_Silent_p.D745D	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	745					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CATCTTCCTCGTCATCCCCTG	0.607000													5	274					0	0	1	0	0
UBE2D3	7323	broad.mit.edu	37	4	103720581	103720581	+	Nonsense_Mutation	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr4:103720581A>T	ENST00000453744.2	-	7	894	c.381T>A	c.(379-381)taT>taA	p.Y127*	UBE2D3_ENST00000504211.1_Nonsense_Mutation_p.Y98*|UBE2D3_ENST00000502404.1_Nonsense_Mutation_p.Y98*|UBE2D3_ENST00000507845.1_Nonsense_Mutation_p.Y98*|UBE2D3_ENST00000394803.5_Nonsense_Mutation_p.Y127*|UBE2D3_ENST00000343106.5_Nonsense_Mutation_p.Y127*|UBE2D3_ENST00000357194.6_Nonsense_Mutation_p.Y129*|UBE2D3_ENST00000321805.7_Nonsense_Mutation_p.Y127*|UBE2D3_ENST00000394801.4_Nonsense_Mutation_p.Y127*|UBE2D3_ENST00000394804.2_Nonsense_Mutation_p.Y127*|UBE2D3_ENST00000338145.3_Nonsense_Mutation_p.Y127*|UBE2D3_ENST00000349311.8_Nonsense_Mutation_p.Y127*|UBE2D3_ENST00000350435.7_Nonsense_Mutation_p.Y121*|UBE2D3_ENST00000505207.1_Nonsense_Mutation_p.Y98*	NM_181891.1	NP_871620.1	P61077	UB2D3_HUMAN	ubiquitin-conjugating enzyme E2D 3	127					apoptosis|BMP signaling pathway|DNA repair|negative regulation of type I interferon production|proteasomal ubiquitin-dependent protein catabolic process|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein monoubiquitination|transforming growth factor beta receptor signaling pathway	endosome membrane|plasma membrane	ATP binding|protein binding|ubiquitin-protein ligase activity			kidney(1)|lung(3)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.13e-08)		TGTCTGTTTTATAGATCCGTG	0.358000													4	123					0	0	1	0	0
ZCCHC17	51538	broad.mit.edu	37	1	31836952	31836952	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:31836952G>A	ENST00000373714.1	+	8	899	c.638G>A	c.(637-639)gGc>gAc	p.G213D	ZCCHC17_ENST00000422613.2_Missense_Mutation_p.G215D|ZCCHC17_ENST00000344147.5_Missense_Mutation_p.G213D|ZCCHC17_ENST00000546109.1_Missense_Mutation_p.G205D			Q9NP64	NO40_HUMAN	zinc finger, CCHC domain containing 17	213	Lys-rich.					nucleolus	RNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(2)|ovary(1)|skin(1)	6		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)|all_neural(195;0.146)|Medulloblastoma(700;0.151)|Breast(348;0.222)		STAD - Stomach adenocarcinoma(196;0.0215)|READ - Rectum adenocarcinoma(331;0.168)		AGTGATACAGGCAAGAGGGCA	0.393000													13	206					0	0	1	0	0
CCT2	10576	broad.mit.edu	37	12	69986754	69986754	+	Splice_Site	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:69986754A>T	ENST00000543146.2	+	9	1091		c.e9-1		CCT2_ENST00000299300.6_Splice_Site|CCT2_ENST00000544368.2_Splice_Site	NM_001198842.1	NP_001185771.1	P78371	TCPB_HUMAN	chaperonin containing TCP1, subunit 2 (beta)						'de novo' posttranslational protein folding	nucleus	ATP binding|unfolded protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(1)	24	all_cancers(2;7.7e-106)|Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.72e-18)|GBM - Glioblastoma multiforme(2;2.58e-10)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			CGTTTGTCTTAGATATTTGGT	0.423000													4	82					0	0	1	0	0
TOPORS	10210	broad.mit.edu	37	9	32541886	32541886	+	Silent	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr9:32541886A>T	ENST00000360538.2	-	3	2753	c.2637T>A	c.(2635-2637)acT>acA	p.T879T	TOPORS_ENST00000379858.1_Silent_p.T814T	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	879	Interaction with TOP1.|Interaction with UBE2I.|Lys-rich.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		tATGGTGTTTAGTTGTATCAG	0.383000													8	314					0	0	1	0	0
FLT3	2322	broad.mit.edu	37	13	28608446	28608446	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr13:28608446A>T	ENST00000380982.4	-	13	1777	c.1696T>A	c.(1696-1698)Tac>Aac	p.Y566N	FLT3_ENST00000241453.7_Missense_Mutation_p.Y566N|FLT3_ENST00000537084.1_Missense_Mutation_p.Y566N			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	566					positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	ACCTTTTTGTACTTGTGACAA	0.373000			"""Mis, O"""		"""AML, ALL"""								5	377					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24834019	24834019	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:24834019G>A	ENST00000376451.2	+	15	4630	c.4370G>A	c.(4369-4371)cGc>cAc	p.R1457H	KIAA1217_ENST00000396446.1_Missense_Mutation_p.R858H|KIAA1217_ENST00000307544.6_Missense_Mutation_p.R924H|KIAA1217_ENST00000458595.1_Missense_Mutation_p.R1180H|KIAA1217_ENST00000376452.3_Missense_Mutation_p.R1205H|KIAA1217_ENST00000376462.1_Missense_Mutation_p.R1095H|KIAA1217_ENST00000396445.1_Missense_Mutation_p.R898H|KIAA1217_ENST00000376454.3_Missense_Mutation_p.R1774H			Q5T5P2	SKT_HUMAN	KIAA1217	1774					embryonic skeletal system development	cytoplasm		p.R1774H(1)		breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CAGGATCCCCGCCAATATCGT	0.502000													4	194					0	0	1	0	0
MMP2	4313	broad.mit.edu	37	16	55523683	55523683	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:55523683C>T	ENST00000219070.4	+	7	1636	c.1127C>T	c.(1126-1128)gCg>gTg	p.A376V	MMP2_ENST00000570308.1_Missense_Mutation_p.A300V|MMP2_ENST00000437642.2_Missense_Mutation_p.A326V|MMP2_ENST00000543485.1_Missense_Mutation_p.A300V	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	376	Collagen-binding.|Fibronectin type-II 3.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	ATGTGGTGTGCGACCACAGCC	0.582000													4	259					0	0	1	0	0
BMS1	9790	broad.mit.edu	37	10	43318593	43318593	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:43318593G>A	ENST00000374518.4	+	20	3223	c.3160G>A	c.(3160-3162)Gcc>Acc	p.A1054T		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	1054					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						CTTGGAAGTGGCCAAATTTGA	0.423000													6	798					0	0	1	0	0
FAM208B	54906	broad.mit.edu	37	10	5789569	5789569	+	Silent	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:5789569A>T	ENST00000328090.5	+	15	4810	c.4185A>T	c.(4183-4185)gtA>gtT	p.V1395V		NM_017782.4	NP_060252.4	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	1395																	TTGATTCTGTAATTGAAGAAG	0.373000													6	342					0	0	1	0	0
FTSJ3	117246	broad.mit.edu	37	17	61897195	61897195	+	Silent	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:61897195A>T	ENST00000427159.2	-	21	3156	c.2511T>A	c.(2509-2511)cgT>cgA	p.R837R		NM_017647.3	NP_060117.3	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3 (E. coli)	837					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						TTTGTTCCTTACGTTGCTGTG	0.537000													23	1451					0	0	1	0	0
CES3	23491	broad.mit.edu	37	16	67006335	67006335	+	Silent	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:67006335G>A	ENST00000303334.4	+	11	1439	c.1368G>A	c.(1366-1368)gtG>gtA	p.V456V	CES3_ENST00000394037.1_Silent_p.V456V|CES3_ENST00000543856.1_Silent_p.V95V	NM_024922.5	NP_079198.2	Q6UWW8	EST3_HUMAN	carboxylesterase 3	456						endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	24		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0488)|Epithelial(162;0.127)		CTGCCTGGGTGAAGGCTGATC	0.532000													25	401					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81188376	81188376	+	Silent	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr15:81188376C>T	ENST00000394685.3	+	12	1805	c.1386C>T	c.(1384-1386)tgC>tgT	p.C462C	KIAA1199_ENST00000356249.5_Silent_p.C462C|KIAA1199_ENST00000220244.3_Silent_p.C462C			Q8WUJ3	K1199_HUMAN	KIAA1199	462										breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						GCAGATCCTGCGCCCCCAACC	0.463000													3	174					0	0	1	0	0
LRRC17	10234	broad.mit.edu	37	7	102574960	102574960	+	Missense_Mutation	SNP	T	T	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr7:102574960T>A	ENST00000249377.4	+	2	881	c.600T>A	c.(598-600)aaT>aaA	p.N200K	FBXL13_ENST00000393772.2_Intron|FBXL13_ENST00000455112.2_Intron|FBXL13_ENST00000456695.1_Intron|LRRC17_ENST00000339431.4_Missense_Mutation_p.N200K|FBXL13_ENST00000379308.3_Intron|FBXL13_ENST00000379305.3_Intron|FBXL13_ENST00000313221.4_Intron|FBXL13_ENST00000379306.3_Intron|FBXL13_ENST00000436908.1_Intron	NM_005824.2	NP_005815.2	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17	200	LRRCT 1.				bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	17						AACAAAAAAATAAAAAACTGC	0.423000													5	142					0	0	1	0	0
SAFB	6294	broad.mit.edu	37	19	5661631	5661631	+	Silent	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:5661631G>A	ENST00000292123.5	+	15	2072	c.1965G>A	c.(1963-1965)caG>caA	p.Q655Q	SAFB_ENST00000433404.1_Silent_p.Q485Q|SAFB_ENST00000588852.1_Silent_p.Q655Q|SAFB_ENST00000454510.1_Silent_p.Q586Q|SAFB_ENST00000538656.1_Silent_p.Q497Q|SAFB_ENST00000592224.1_Silent_p.Q654Q	NM_001201338.1|NM_001201339.1|NM_002967.3	NP_001188267.1|NP_001188268.1|NP_002958.2	Q15424	SAFB1_HUMAN	scaffold attachment factor B	655	Arg-rich.|Glu-rich.|Interaction with POLR2A.|Interaction with SAFB2.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(1)	23				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		TGGCCTTCCAGCGCCAGCGGC	0.697000													3	25					0	0	1	0	0
MON2	23041	broad.mit.edu	37	12	62928623	62928623	+	Splice_Site	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:62928623A>T	ENST00000393630.3	+	13	2024		c.e13-1		MON2_ENST00000552738.1_Splice_Site|MON2_ENST00000552115.1_Splice_Site|MON2_ENST00000393632.2_Splice_Site|MON2_ENST00000393629.2_Splice_Site|MON2_ENST00000546600.1_Splice_Site|MON2_ENST00000280379.6_Splice_Site	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)						Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TTTTCCTTTAAGTTAGTAGGG	0.323000													7	162					0	0	1	0	0
PARN	5073	broad.mit.edu	37	16	14540777	14540777	+	Nonsense_Mutation	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:14540777A>T	ENST00000437198.2	-	23	1973	c.1832T>A	c.(1831-1833)tTa>tAa	p.L611*	PARN_ENST00000539279.1_Nonsense_Mutation_p.L436*|PARN_ENST00000420015.2_Nonsense_Mutation_p.L565*|PARN_ENST00000341484.7_Nonsense_Mutation_p.L550*	NM_001134477.2|NM_002582.3	NP_001127949.1|NP_002573.1	O95453	PARN_HUMAN	poly(A)-specific ribonuclease	611					female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|urinary_tract(1)	21						CATTCTTTTTAATTTCTTGGC	0.478000													5	227					0	0	1	0	0
LPCAT2	54947	broad.mit.edu	37	16	55584859	55584859	+	Splice_Site	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:55584859A>T	ENST00000262134.5	+	11	1245		c.e11-1			NM_017839.4	NP_060309.2	Q7L5N7	PCAT2_HUMAN	lysophosphatidylcholine acyltransferase 2						cellular membrane organization|platelet activating factor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|Golgi stack|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	12						TTGTTTGTTTAGATTAGATTG	0.313000													5	299					0	0	1	0	0
BBS2	583	broad.mit.edu	37	16	56530916	56530916	+	Silent	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:56530916G>A	ENST00000245157.5	-	15	2293	c.1873C>T	c.(1873-1875)Ctg>Ttg	p.L625L	BBS2_ENST00000568104.1_Silent_p.L579L	NM_031885.3	NP_114091.3	Q9BXC9	BBS2_HUMAN	Bardet-Biedl syndrome 2	625					adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)	26						GCTCCGACCAGCAAACTTCGG	0.443000									Bardet-Biedl syndrome				6	847					0	0	1	0	0
PAX3	5077	broad.mit.edu	37	2	223066658	223066658	+	Silent	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:223066658C>T	ENST00000350526.4	-	8	1561	c.1425G>A	c.(1423-1425)aaG>aaA	p.K475K	PAX3_ENST00000392070.2_Intron|PAX3_ENST00000392069.2_Intron|PAX3_ENST00000409551.3_Intron|PAX3_ENST00000344493.4_Intron|PAX3_ENST00000336840.6_Intron	NM_181457.3	NP_852122.1	P23760	PAX3_HUMAN	paired box 3	475					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/NCOA2(4)|PAX3/NCOA1(8)|PAX3/FOXO1(749)	NS(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(13)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	38		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAGTCCAAGGCTTACTTTGTC	0.478000			T	"""FOXO1A, NCOA1"""	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						17	81					0	0	1	0	0
TAS2R3	50831	broad.mit.edu	37	7	141464711	141464711	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr7:141464711A>T	ENST00000247879.2	+	1	815	c.753A>T	c.(751-753)ttA>ttT	p.L251F	SSBP1_ENST00000465582.1_Intron	NM_016943.2	NP_058639.1	Q9NYW6	TA2R3_HUMAN	taste receptor, type 2, member 3	251					sensory perception of taste		taste receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)	14	Melanoma(164;0.0171)					ttgctttcttAATTGCATCAT	0.408000													7	432					0	0	1	0	0
TRMT6	51605	broad.mit.edu	37	20	5924825	5924825	+	Silent	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr20:5924825A>T	ENST00000203001.2	-	4	571	c.441T>A	c.(439-441)atT>atA	p.I147I	TRMT6_ENST00000453074.2_5'UTR|TRMT6_ENST00000473131.1_5'UTR	NM_015939.3	NP_057023.2	Q9UJA5	TRM6_HUMAN	tRNA methyltransferase 6 homolog (S. cerevisiae)	147					regulation of translational initiation|tRNA processing	nucleus	protein binding|translation initiation factor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)	15						TCTTCTTTTTAATATATTTAT	0.234000													3	32					0	0	1	0	0
SIGLEC16	400709	broad.mit.edu	37	19	50473431	50473431	+	RNA	SNP	T	T	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:50473431T>G	ENST00000602139.1	+	0	432									sialic acid binding Ig-like lectin 16 (gene/pseudogene)											endometrium(2)|kidney(2)|lung(6)	10						CGTGAACAATTTGTTCTAAAA	0.547000													3	13					0	0	1	0	0
TICRR	90381	broad.mit.edu	37	15	90125915	90125915	+	Splice_Site	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr15:90125915A>T	ENST00000268138.7	+	2	759		c.e2-1		TICRR_ENST00000560985.1_Splice_Site|RP11-429B14.1_ENST00000559041.1_RNA					TOPBP1-interacting checkpoint and replication regulator																		GTTTTATTTTAGTTGTGGGAA	0.398000													3	87					0	0	1	0	0
OR4A47	403253	broad.mit.edu	37	11	48511101	48511101	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:48511101A>T	ENST00000446524.1	+	1	833	c.757A>T	c.(757-759)Att>Ttt	p.I253F		NM_001005512.2	NP_001005512.2	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A, member 47	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(18)|ovary(1)|skin(1)|urinary_tract(2)	29						TGTTCCTTGTATTTTTATGTA	0.428000													9	1153					0	0	1	0	0
CEBPZ	10153	broad.mit.edu	37	2	37428925	37428925	+	Silent	SNP	A	A	T	rs148813970	by1000genomes	TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:37428925A>T	ENST00000234170.5	-	16	3292	c.3147T>A	c.(3145-3147)acT>acA	p.T1049T	AC007390.5_ENST00000397064.2_Intron|AC007390.5_ENST00000392061.2_Intron|AC007390.5_ENST00000402297.1_Intron|AC007390.5_ENST00000406711.1_Intron|AC007390.5_ENST00000397226.2_Intron	NM_005760.2	NP_005751.2	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein (C/EBP), zeta	1049					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			breast(3)|endometrium(2)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28		all_hematologic(82;0.21)				TTTGTTTTTTAGTTTTTTGAG	0.294000													3	22					0	0	1	0	0
TANGO6	79613	broad.mit.edu	37	16	68934341	68934341	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:68934341A>T	ENST00000261778.1	+	8	1394	c.1382A>T	c.(1381-1383)tAc>tTc	p.Y461F		NM_024562.1	NP_078838.1			transport and golgi organization 6 homolog (Drosophila)																		TTCTAGGTGTACGTGGTTGGG	0.458000													6	305					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7667441	7667441	+	Silent	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:7667441C>T	ENST00000572933.1	+	20	4646	c.3186C>T	c.(3184-3186)agC>agT	p.S1062S	DNAH2_ENST00000389173.2_Silent_p.S1062S			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1062	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TCAGAATCAGCCGCCCTCCGC	0.647000													5	312					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38853184	38853184	+	Missense_Mutation	SNP	G	G	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:38853184G>C	ENST00000409235.3	+	19	2441	c.2326G>C	c.(2326-2328)Ggc>Cgc	p.G776R	CATSPERG_ENST00000215069.4_3'UTR|CATSPERG_ENST00000410018.1_Missense_Mutation_p.G736R	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	776					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						GTCGGCGCAGGGCCACTCGTT	0.642000													11	206					0	0	1	0	0
OR2G6	391211	broad.mit.edu	37	1	248685494	248685494	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:248685494G>A	ENST00000343414.4	+	1	579	c.547G>A	c.(547-549)Gtg>Atg	p.V183M		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGAGGTGCCAGTGCTCATCAA	0.512000													3	153					0	0	1	0	0
DEFB126	81623	broad.mit.edu	37	20	126121	126121	+	Missense_Mutation	SNP	G	G	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr20:126121G>C	ENST00000382398.3	+	2	384	c.124G>C	c.(124-126)Gag>Cag	p.E42Q	DEFB126_ENST00000542572.1_3'UTR	NM_030931.2	NP_112193.1	Q9BYW3	DB126_HUMAN	defensin, beta 126	42					defense response to bacterium	extracellular region				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(1)	4		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			CAAACCTGAAGAGATGCATGT	0.398000													5	539					0	0	1	0	0
DCAF17	80067	broad.mit.edu	37	2	172314880	172314880	+	Splice_Site	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:172314880A>T	ENST00000375255.3	+	8	1059		c.e8-1		DCAF17_ENST00000468592.1_Intron|DCAF17_ENST00000539783.1_Splice_Site	NM_025000.3	NP_079276.2	Q5H9S7	DCA17_HUMAN	DDB1 and CUL4 associated factor 17							CUL4 RING ubiquitin ligase complex|integral to membrane|nucleolus				endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|prostate(1)	17						TTTTGTTTTTAGTTCATGCAA	0.358000													4	162					0	0	1	0	0
MKL2	57496	broad.mit.edu	37	16	14345845	14345845	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:14345845C>T	ENST00000571589.1	+	14	2702	c.2530C>T	c.(2530-2532)Cca>Tca	p.P844S	MKL2_ENST00000574045.1_Missense_Mutation_p.P794S|MKL2_ENST00000341243.5_Missense_Mutation_p.P833S|MKL2_ENST00000318282.5_Missense_Mutation_p.P794S	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	833					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TGCTCCGCTTCCATCCCTGCA	0.498000													57	247					0	0	1	0	0
SMG7	9887	broad.mit.edu	37	1	183495733	183495733	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:183495733A>T	ENST00000367537.3	+	6	597	c.402A>T	c.(400-402)ttA>ttT	p.L134F	SMG7_ENST00000508461.1_Missense_Mutation_p.L63F|SMG7_ENST00000456731.2_Missense_Mutation_p.L63F|SMG7_ENST00000507406.1_3'UTR|SMG7_ENST00000507469.1_Missense_Mutation_p.L105F|SMG7_ENST00000347615.2_Missense_Mutation_p.L105F|SMG7_ENST00000515829.2_Missense_Mutation_p.L105F			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor	105					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						TCTTTTAGTTATTACAAGAAC	0.348000													4	158					0	0	1	0	0
FIGN	55137	broad.mit.edu	37	2	164466457	164466457	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:164466457C>A	ENST00000333129.3	-	3	2199	c.1885G>T	c.(1885-1887)Gcc>Tcc	p.A629S	FIGN_ENST00000409634.1_Intron	NM_018086.2	NP_060556.2	Q5HY92	FIGN_HUMAN	fidgetin	629						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(1)|prostate(2)|skin(1)	47						TTACTGGTGGCACAAATTACT	0.448000													5	389					0.00198382	0.00198382	1	1	0
ACSBG2	81616	broad.mit.edu	37	19	6177251	6177251	+	Missense_Mutation	SNP	T	T	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:6177251T>G	ENST00000588304.1	+	8	1046	c.600T>G	c.(598-600)atT>atG	p.I200M	ACSBG2_ENST00000591403.1_Missense_Mutation_p.I250M|ACSBG2_ENST00000588485.1_Missense_Mutation_p.I63M|ACSBG2_ENST00000591741.1_3'UTR|ACSBG2_ENST00000252669.5_Missense_Mutation_p.I250M|ACSBG2_ENST00000586696.1_Missense_Mutation_p.I250M			Q5FVE4	ACBG2_HUMAN	acyl-CoA synthetase bubblegum family member 2	250					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity	p.I250M(3)		breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(3)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TCACGTGGATTGCAGGAGCAG	0.433000													3	117					0	0	1	0	0
PIAS1	8554	broad.mit.edu	37	15	68480158	68480158	+	Missense_Mutation	SNP	T	T	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr15:68480158T>G	ENST00000545237.1	+	15	2688	c.1947T>G	c.(1945-1947)atT>atG	p.I649M	PIAS1_ENST00000249636.6_Missense_Mutation_p.I647M			O75925	PIAS1_HUMAN	protein inhibitor of activated STAT, 1	647					androgen receptor signaling pathway|interferon-gamma-mediated signaling pathway|JAK-STAT cascade|positive regulation of protein sumoylation|positive regulation of transcription, DNA-dependent|regulation of interferon-gamma-mediated signaling pathway|transcription, DNA-dependent	nuclear speck	androgen receptor binding|DNA binding|enzyme binding|SUMO ligase activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)	24						TACCAGACATTATTTCATTGG	0.502000													10	47					0	0	1	0	0
PEX6	5190	broad.mit.edu	37	6	42946220	42946220	+	Silent	SNP	C	C	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:42946220C>A	ENST00000304611.8	-	1	738	c.669G>T	c.(667-669)gtG>gtT	p.V223V	PEX6_ENST00000244546.4_Silent_p.V223V	NM_000287.3	NP_000278.3	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	223					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(3)	15			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			GGGCCACCCACACCCATTCGC	0.622000													47	59					2.52991e-16	2.69025e-16	1	1	0
F5	2153	broad.mit.edu	37	1	169510405	169510405	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:169510405C>A	ENST00000367796.3	-	13	4139	c.3938G>T	c.(3937-3939)aGt>aTt	p.S1313I	F5_ENST00000367797.3_Missense_Mutation_p.S1308I			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1308	35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.|B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GTTTGTCTGACTGAGTTCTGG	0.512000													6	786					0.00198382	0.00198382	1	1	0
TMOD2	29767	broad.mit.edu	37	15	52074920	52074920	+	Silent	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr15:52074920C>T	ENST00000249700.4	+	7	848	c.627C>T	c.(625-627)aaC>aaT	p.N209N	TMOD2_ENST00000539962.2_Silent_p.N165N|TMOD2_ENST00000435126.2_Intron	NM_001142885.1|NM_014548.3	NP_001136357.1|NP_055363.1	Q9NZR1	TMOD2_HUMAN	tropomodulin 2 (neuronal)	209					nervous system development	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	16				all cancers(107;0.00435)		TGTCTTAGAACATTCCAATTC	0.478000													10	374					0	0	1	0	0
IL26	55801	broad.mit.edu	37	12	68619252	68619252	+	Nonsense_Mutation	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:68619252A>T	ENST00000229134.4	-	2	264	c.200T>A	c.(199-201)tTa>tAa	p.L67*	IFNG-AS1_ENST00000536914.1_RNA	NM_018402.1	NP_060872.1	Q9NPH9	IL26_HUMAN	interleukin 26	67					cell-cell signaling|negative regulation of epithelial cell proliferation|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of JAK-STAT cascade|positive regulation of protein kinase B signaling cascade|positive regulation of stress-activated MAPK cascade|positive regulation of transcription from RNA polymerase II promoter	cytosol|extracellular space|soluble fraction	cytokine activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	12			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000515)		TTTCTTTTTTAATAATCGTAT	0.284000													4	128					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:207025358A>G	ENST00000392222.2	+	2	502	c.127A>G	c.(127-129)Agc>Ggc	p.S43G	EEF1B2_ENST00000392221.1_Missense_Mutation_p.S43G|EEF1B2_ENST00000236957.5_Missense_Mutation_p.S43G	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.S43G(4)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGCCGTGTCCAGCCCACCGCC	0.468000													3	37					0	0	1	0	0
CCT4	10575	broad.mit.edu	37	2	62099298	62099298	+	Silent	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:62099298G>A	ENST00000394440.3	-	12	1706	c.1410C>T	c.(1408-1410)ggC>ggT	p.G470G	CCT4_ENST00000544079.1_Silent_p.G440G|CCT4_ENST00000544185.1_Silent_p.G320G|CCT4_ENST00000461540.2_Intron|CCT4_ENST00000538252.1_Silent_p.G414G|AC107081.5_ENST00000425779.1_RNA	NM_006430.3	NP_006421.2	P50991	TCPD_HUMAN	chaperonin containing TCP1, subunit 4 (delta)	470					'de novo' posttranslational protein folding	melanosome|microtubule organizing center|nucleus	ATP binding|unfolded protein binding			breast(1)|large_intestine(2)|lung(6)|ovary(2)	11	Lung NSC(7;0.035)|all_lung(7;0.0691)		LUSC - Lung squamous cell carcinoma(7;6.5e-06)|Epithelial(17;0.0647)|all cancers(80;0.221)			TGGGATTCAGGCCGGCATTTT	0.433000													3	98					0	0	1	0	0
CENPJ	55835	broad.mit.edu	37	13	25458526	25458526	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr13:25458526C>T	ENST00000381884.4	-	14	3738	c.3553G>A	c.(3553-3555)Ggg>Agg	p.G1185R	CENPJ_ENST00000545981.1_3'UTR	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	1185					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		ATGGTCTTCCCATCTGCACTC	0.423000													5	295					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99514149	99514149	+	Silent	SNP	T	T	G	rs144636435		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:99514149T>G	ENST00000261037.3	+	5	1784	c.1404T>G	c.(1402-1404)ggT>ggG	p.G468G	COL8A1_ENST00000273342.4_Silent_p.G468G	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	468	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						GGCAAAAAGGTGTACCAGGAC	0.607000													4	40					0	0	1	0	0
POC1A	25886	broad.mit.edu	37	3	52181050	52181050	+	Missense_Mutation	SNP	C	C	T	rs138043185	by1000genomes	TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:52181050C>T	ENST00000394970.2	-	5	834	c.517G>A	c.(517-519)Gac>Aac	p.D173N	POC1A_ENST00000296484.2_Missense_Mutation_p.D173N|POC1A_ENST00000474012.1_Missense_Mutation_p.D135N	NM_001161580.1	NP_001155052.1	Q8NBT0	POC1A_HUMAN	POC1 centriolar protein A	173						centriole|microtubule basal body				endometrium(1)|large_intestine(4)|liver(1)|lung(4)|prostate(3)|skin(1)	14						CTGCTCTTGTCCCACAGCTTA	0.577000													12	99					0	0	1	0	0
MRO	83876	broad.mit.edu	37	18	48335776	48335776	+	Splice_Site	SNP	T	T	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr18:48335776T>A	ENST00000428869.2	-	4	255		c.e4-2		MRO_ENST00000588444.1_Splice_Site|MRO_ENST00000431965.2_Intron|MRO_ENST00000256425.2_Splice_Site|MRO_ENST00000398439.3_Splice_Site|MRO_ENST00000436348.2_Intron|MRO_ENST00000587291.1_Intron			Q9BYG7	MSTRO_HUMAN	maestro							nucleolus	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)|skin(2)	10		Colorectal(6;0.0596)		Colorectal(21;0.082)		TCCATGGAACTAAAAACAAAA	0.428000													4	68					0	0	1	0	0
OSBPL11	114885	broad.mit.edu	37	3	125271258	125271258	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:125271258C>A	ENST00000296220.5	-	9	1710	c.1421G>T	c.(1420-1422)aGc>aTc	p.S474I		NM_022776.4	NP_073613.2	Q9BXB4	OSB11_HUMAN	oxysterol binding protein-like 11	474					lipid transport		lipid binding			NS(1)|breast(1)|cervix(1)|kidney(2)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	27						GGAAGAACTGCTAAAAACACT	0.453000													8	150					5.18039e-06	5.3578e-06	1	1	0
CA13	377677	broad.mit.edu	37	8	86163153	86163153	+	Silent	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr8:86163153A>T	ENST00000321764.3	+	2	524	c.222A>T	c.(220-222)acA>acT	p.T74T	CA13_ENST00000517298.1_3'UTR	NM_198584.2	NP_940986.1	Q8N1Q1	CAH13_HUMAN	carbonic anhydrase XIII	74					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding			large_intestine(1)|lung(6)	7						TTGATGACACAGAGAACAAAT	0.383000													141	218					0	0	1	0	0
PRDM8	56978	broad.mit.edu	37	4	81123132	81123132	+	Silent	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr4:81123132G>A	ENST00000339711.4	+	10	1747	c.516G>A	c.(514-516)gcG>gcA	p.A172A	PRDM8_ENST00000504452.1_Silent_p.A172A|PRDM8_ENST00000415738.2_Silent_p.A172A	NM_020226.3	NP_064611.3	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(2)	10						CCTATGTGGCGCATCTGCGTT	0.597000											OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	282					0	0	1	0	0
PPM1G	5496	broad.mit.edu	37	2	27606364	27606364	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:27606364C>T	ENST00000344034.4	-	7	1334	c.1070G>A	c.(1069-1071)gGc>gAc	p.G357D	PPM1G_ENST00000350803.4_Missense_Mutation_p.G357D	NM_177983.2	NP_817092.1	O15355	PPM1G_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1G	357					cell cycle arrest|protein dephosphorylation	cytoplasm|nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	19	Acute lymphoblastic leukemia(172;0.155)					TAAAGCTTTGCCAGCCTCAGA	0.527000													4	106					0	0	1	0	0
OR4F15	390649	broad.mit.edu	37	15	102358493	102358493	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr15:102358493A>T	ENST00000332238.4	+	1	128	c.104A>T	c.(103-105)tAc>tTc	p.Y35F		NM_001001674.1	NP_001001674.1	Q8NGB8	O4F15_HUMAN	olfactory receptor, family 4, subfamily F, member 15	35					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(10)	19	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TTGTTGTTCTACTTTGCGAGC	0.423000													7	754					0	0	1	0	0
MMP3	4314	broad.mit.edu	37	11	102713276	102713276	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:102713276C>T	ENST00000299855.5	-	3	641	c.385G>A	c.(385-387)Gct>Act	p.A129T		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	129					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	GAATCAACAGCATCTTTTGGC	0.383000													39	153					0	0	1	0	0
YWHAEP7	284100	broad.mit.edu	37	17	36214775	36214775	+	RNA	SNP	G	G	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:36214775G>T	ENST00000590732.1	-	0	291					NR_024178.1													p.T41N(6)									CTTGCCAGTGGTAGCTGCTGG	0.353000													3	67					2.56e-06	2.66593e-06	1	1	0
VPS41	27072	broad.mit.edu	37	7	38791915	38791915	+	Splice_Site	SNP	T	T	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr7:38791915T>A	ENST00000310301.4	-	22	1843		c.e22-2		VPS41_ENST00000395969.2_Splice_Site	NM_014396.3	NP_055211.2	P49754	VPS41_HUMAN	vacuolar protein sorting 41 homolog (S. cerevisiae)						Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	44						ATGCAAATACTAAAAGGAACA	0.388000													5	214					0	0	1	0	0
PRRC2C	23215	broad.mit.edu	37	1	171482132	171482132	+	Splice_Site	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:171482132A>T	ENST00000367742.3	+	3	354		c.e3-1		PRRC2C_ENST00000392078.3_Splice_Site|PRRC2C_ENST00000476522.1_Splice_Site|PRRC2C_ENST00000338920.4_Intron|PRRC2C_ENST00000426496.2_Intron			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C								protein C-terminus binding										ATTGATCTTTAGTTGCAGCTC	0.363000													5	211					0	0	1	0	0
TAF7	6879	broad.mit.edu	37	5	140699058	140699058	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:140699058G>A	ENST00000313368.5	-	1	1272	c.554C>T	c.(553-555)gCc>gTc	p.A185V		NM_005642.2	NP_005633.2	Q15545	TAF7_HUMAN	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa	185					negative regulation of histone acetylation|negative regulation of protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|spermine transport|transcription initiation from RNA polymerase II promoter	Golgi apparatus|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	histone acetyltransferase binding|thyroid hormone receptor binding|transcription coactivator activity|transcription regulatory region DNA binding|vitamin D receptor binding			central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCATCTTCGGCAATTATTTC	0.423000													3	124					0	0	1	0	0
NPAS3	64067	broad.mit.edu	37	14	33836390	33836390	+	Splice_Site	SNP	A	A	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr14:33836390A>T	ENST00000548645.1	+	3	340		c.e3-1		NPAS3_ENST00000551492.1_Intron|NPAS3_ENST00000346562.2_Intron|NPAS3_ENST00000341321.4_Splice_Site|NPAS3_ENST00000357798.5_Splice_Site|NPAS3_ENST00000356141.4_Splice_Site|NPAS3_ENST00000547068.1_Intron|NPAS3_ENST00000551008.1_Splice_Site			Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		TTTTCTTTTAAGTTATAGGTG	0.368000													3	33					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23887535	23887535	+	Silent	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr14:23887535C>T	ENST00000355349.3	-	30	4215	c.4053G>A	c.(4051-4053)acG>acA	p.T1351T		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1351					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.T1351T(1)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CCTTGGCCTCCGTCTCCTCCT	0.672000													3	66					0	0	1	0	0
FBXO5	26271	broad.mit.edu	37	6	153296565	153296565	+	Missense_Mutation	SNP	G	G	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:153296565G>C	ENST00000367241.3	-	2	537	c.157C>G	c.(157-159)Ccg>Gcg	p.P53A	FBXO5_ENST00000229758.3_Missense_Mutation_p.P99A	NM_001142522.1	NP_001135994.1	Q9UKT4	FBX5_HUMAN	F-box protein 5	99					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm|spindle	metal ion binding|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|prostate(2)|upper_aerodigestive_tract(1)	15		Ovarian(120;0.125)		OV - Ovarian serous cystadenocarcinoma(155;4.38e-10)|BRCA - Breast invasive adenocarcinoma(81;0.0893)		CTCACAATCGGTGACCCAATA	0.403000													4	127					0	0	1	0	0
ZNF211	10520	broad.mit.edu	37	19	58152180	58152180	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:58152180C>T	ENST00000544273.1	+	5	689	c.362C>T	c.(361-363)gCc>gTc	p.A121V	ZNF211_ENST00000541801.1_Missense_Mutation_p.A100V|ZNF211_ENST00000299871.5_Missense_Mutation_p.A174V|ZNF211_ENST00000420680.1_Missense_Mutation_p.A113V|ZNF211_ENST00000391703.3_Missense_Mutation_p.A48V|ZNF211_ENST00000347302.3_Missense_Mutation_p.A109V|ZNF211_ENST00000254182.7_Missense_Mutation_p.A100V|ZNF211_ENST00000240731.4_Missense_Mutation_p.A122V			Q13398	ZN211_HUMAN	zinc finger protein 211	109						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCCCAGAATGCCGACTCCTGT	0.453000													3	187					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15586419	15586419	+	Silent	SNP	C	C	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:15586419C>T	ENST00000292609.4	-	2	1191	c.1062G>A	c.(1060-1062)caG>caA	p.Q354Q	PGLYRP2_ENST00000340880.4_Silent_p.Q354Q			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	354					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						GGCTCATGCACTGAAGCTGGA	0.582000													27	319					0	0	1	0	0
NXF5	55998	broad.mit.edu	37	X	101095848	101095848	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chrX:101095848C>A	ENST00000537026.1	-	9	859	c.500G>T	c.(499-501)tGc>tTc	p.C167F	NXF5_ENST00000361708.2_Missense_Mutation_p.C167F|NXF5_ENST00000473265.2_Missense_Mutation_p.C167F	NM_032946.2	NP_116564.2	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	167					mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|skin(1)	30						TTTGTTGTTGCACAAGTTCAA	0.483000													36	94					1.41504e-22	1.63273e-22	0.859065	1	0
SCAND3	114821	broad.mit.edu	37	6	28541173	28541173	+	Silent	SNP	G	G	A			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:28541173G>A	ENST00000452236.2	-	4	3110	c.2493C>T	c.(2491-2493)gcC>gcT	p.A831A		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	831					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						ttttagacttggcaaccggaa	0.408000													5	281					0	0	0.184627	0	0
MYH3	4621	broad.mit.edu	37	17	10543475	10543475	+	Silent	SNP	G	G	A			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:10543475G>A	ENST00000583535.1	-	22	2607	c.2520C>T	c.(2518-2520)ctC>ctT	p.L840L	MYH3_ENST00000226209.7_Silent_p.L840L	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	840					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						CACTCTTGAGGAGGGGCTTGA	0.473000													11	246					0	0	0.361761	0	0
MT-ND5	4540	broad.mit.edu	37	MT	12508	12508	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chrM:12508G>A	ENST00000361567.2	+	1	172	c.172G>A	c.(172-174)Gac>Aac	p.D58N				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	58					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	TCATGTGCCTAGACCAAGAAG	0.398000													12	326					0	0	0.411799	0	0
HRNR	388697	broad.mit.edu	37	1	152191466	152191466	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:152191466C>T	ENST00000368801.2	-	3	2714	c.2639G>A	c.(2638-2640)cGc>cAc	p.R880H	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	880					keratinization		calcium ion binding|protein binding	p.R880H(1)		autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGTCGGCCGCGGCCCGAAGC	0.627000													4	66					0	0	0.150653	0	0
PEX6	5190	broad.mit.edu	37	6	42946220	42946220	+	Silent	SNP	C	C	A			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:42946220C>A	ENST00000304611.8	-	1	738	c.669G>T	c.(667-669)gtG>gtT	p.V223V	PEX6_ENST00000244546.4_Silent_p.V223V	NM_000287.3	NP_000278.3	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	223					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(3)	15			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			GGGCCACCCACACCCATTCGC	0.622000													35	52					6.97489e-18	7.84675e-18	0.804634	1	0
FGD2	221472	broad.mit.edu	37	6	36982762	36982762	+	Missense_Mutation	SNP	T	T	G			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:36982762T>G	ENST00000274963.8	+	8	1148	c.977T>G	c.(976-978)gTc>gGc	p.V326G		NM_173558.3	NP_775829.2	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	326	PH 1.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	25						GAGGGCCCGGTCCTCAAGATC	0.627000													19	47					0	0	0.592651	0	0
OSBPL1A	114876	broad.mit.edu	37	18	21898607	21898607	+	Silent	SNP	G	G	C			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr18:21898607G>C	ENST00000319481.3	-	9	896	c.690C>G	c.(688-690)gtC>gtG	p.V230V		NM_080597.3	NP_542164.2	Q9BXW6	OSBL1_HUMAN	oxysterol binding protein-like 1A	230					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					CTTTGTAGATGACCTGTCAAA	0.284000													6	88					0	0	0.248553	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553994	140553994	+	Silent	SNP	G	G	T			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:140553994G>T	ENST00000231137.3	+	1	1752	c.1578G>T	c.(1576-1578)gcG>gcT	p.A526A		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		526	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.A526A(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTGCAGGCGTTCGAGTTCC	0.706000													5	136					0.000157383	0.000164703	0.278610	1	0
TMOD2	29767	broad.mit.edu	37	15	52074920	52074920	+	Silent	SNP	C	C	T			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr15:52074920C>T	ENST00000249700.4	+	7	848	c.627C>T	c.(625-627)aaC>aaT	p.N209N	TMOD2_ENST00000435126.2_Intron|TMOD2_ENST00000539962.2_Silent_p.N165N	NM_001142885.1|NM_014548.3	NP_001136357.1|NP_055363.1	Q9NZR1	TMOD2_HUMAN	tropomodulin 2 (neuronal)	209					nervous system development	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	16				all cancers(107;0.00435)		TGTCTTAGAACATTCCAATTC	0.478000													8	247					0	0	0.307466	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215597	140215597	+	Silent	SNP	G	G	A			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:140215597G>A	ENST00000525929.1	+	1	1629	c.1629G>A	c.(1627-1629)ccG>ccA	p.P543P	PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA7_ENST00000378125.3_Silent_p.P543P|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000529310.1_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGGCGTGCCGCCTCTGGGCA	0.692000													8	237					0	0	0.361761	0	0
AFF3	3899	broad.mit.edu	37	2	100199272	100199272	+	Silent	SNP	G	G	A	rs148546971		TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:100199272G>A	ENST00000317233.4	-	16	3016	c.2781C>T	c.(2779-2781)ggC>ggT	p.G927G	AFF3_ENST00000409579.1_Silent_p.G952G|AFF3_ENST00000409236.1_Silent_p.G927G|AFF3_ENST00000356421.2_Silent_p.G952G	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	927					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						TGAGGTCTCCGCCGTGAGGCT	0.488000													11	158					0	0	0.411799	0	0
ACAP1	9744	broad.mit.edu	37	17	7253450	7253450	+	Missense_Mutation	SNP	G	G	C			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:7253450G>C	ENST00000158762.3	+	20	2172	c.1966G>C	c.(1966-1968)Gcc>Ccc	p.A656P		NM_014716.3	NP_055531.1	Q15027	ACAP1_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	656	Required for interaction with GULP1.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			NS(1)|breast(5)|cervix(3)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|prostate(3)|skin(1)|urinary_tract(1)	33						CTCCAGGCTCGCCTGCCTGTT	0.622000													10	122					0	0	0.608945	0	0
RLIM	51132	broad.mit.edu	37	X	73812620	73812620	+	Missense_Mutation	SNP	T	T	G			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chrX:73812620T>G	ENST00000332687.6	-	4	748	c.530A>C	c.(529-531)gAa>gCa	p.E177A	RLIM_ENST00000349225.2_Missense_Mutation_p.E177A	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	177					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TCGTGGGTTTTCCACTTGCCT	0.448000													6	295					0	0	0.248553	0	0
COL8A1	1295	broad.mit.edu	37	3	99514149	99514149	+	Silent	SNP	T	T	G	rs144636435		TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:99514149T>G	ENST00000261037.3	+	5	1784	c.1404T>G	c.(1402-1404)ggT>ggG	p.G468G	COL8A1_ENST00000273342.4_Silent_p.G468G	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	468	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						GGCAAAAAGGTGTACCAGGAC	0.607000													7	45					0	0	0.307466	0	0
ETV6	2120	broad.mit.edu	37	12	12022525	12022525	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:12022525C>T	ENST00000396373.4	+	5	905	c.631C>T	c.(631-633)Cgc>Tgc	p.R211C		NM_001987.4	NP_001978.1	P41212	ETV6_HUMAN	ets variant 6	211						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/JAK2(11)|ETV6/ITPR2(2)|ETV6/NTRK3(238)	breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(15)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CATGATCCGCCGCCTCTCCCC	0.622000			T	"""NTRK3, RUNX1, PDGFRB, ABL1, MN1, ABL2, FACL6, CHIC2, ARNT, JAK2, EVI1, CDX2, STL, HLXB9, MDS2, PER1, SYK, TTL, FGFR3, PAX5"""	"""congenital fibrosarcoma, multiple leukemia and lymphoma,  secretory breast, MDS, ALL"""								6	252					0	0	0.361761	0	0
SUV420H1	51111	broad.mit.edu	37	11	67925230	67925230	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:67925230T>C	ENST00000304363.4	-	11	2936	c.2583A>G	c.(2581-2583)atA>atG	p.I861M		NM_017635.3	NP_060105.3	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 (Drosophila)	861					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(15)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46						CTTTTCCAACTATTAACCTCA	0.413000													5	136					0	0	0.217242	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69034497	69034497	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:69034497T>C	ENST00000295381.3	+	5	975	c.556T>C	c.(556-558)Ttc>Ctc	p.F186L	ARHGAP25_ENST00000409030.3_Missense_Mutation_p.F179L|ARHGAP25_ENST00000409220.1_Missense_Mutation_p.F180L|ARHGAP25_ENST00000467265.1_Missense_Mutation_p.F147L|ARHGAP25_ENST00000456116.2_3'UTR|ARHGAP25_ENST00000544262.1_Missense_Mutation_p.F161L|ARHGAP25_ENST00000497079.1_Missense_Mutation_p.F180L|ARHGAP25_ENST00000409202.3_Missense_Mutation_p.F187L	NM_001007231.2	NP_001007232.2	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	186	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						ATGTGCAGAGTTCATCCTGGA	0.577000													5	89					0	0	0.184627	0	0
PAX3	5077	broad.mit.edu	37	2	223066658	223066658	+	Silent	SNP	C	C	T			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:223066658C>T	ENST00000350526.4	-	8	1561	c.1425G>A	c.(1423-1425)aaG>aaA	p.K475K	PAX3_ENST00000409551.3_Intron|PAX3_ENST00000392069.2_Intron|PAX3_ENST00000392070.2_Intron|PAX3_ENST00000336840.6_Intron|PAX3_ENST00000344493.4_Intron	NM_181457.3	NP_852122.1	P23760	PAX3_HUMAN	paired box 3	475					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/NCOA2(4)|PAX3/NCOA1(8)|PAX3/FOXO1(749)	NS(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(13)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	38		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAGTCCAAGGCTTACTTTGTC	0.478000			T	"""FOXO1A, NCOA1"""	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						15	69					0	0	0.500413	0	0
OSBPL11	114885	broad.mit.edu	37	3	125271258	125271258	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:125271258C>A	ENST00000296220.5	-	9	1710	c.1421G>T	c.(1420-1422)aGc>aTc	p.S474I		NM_022776.4	NP_073613.2	Q9BXB4	OSB11_HUMAN	oxysterol binding protein-like 11	474					lipid transport		lipid binding			NS(1)|breast(1)|cervix(1)|kidney(2)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	27						GGAAGAACTGCTAAAAACACT	0.453000													10	138					1.58986e-06	1.70343e-06	0.361761	1	0
CA13	377677	broad.mit.edu	37	8	86163153	86163153	+	Silent	SNP	A	A	T			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr8:86163153A>T	ENST00000321764.3	+	2	524	c.222A>T	c.(220-222)acA>acT	p.T74T	CA13_ENST00000517298.1_3'UTR	NM_198584.2	NP_940986.1	Q8N1Q1	CAH13_HUMAN	carbonic anhydrase XIII	74					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding			large_intestine(1)|lung(6)	7						TTGATGACACAGAGAACAAAT	0.383000													110	199					0	0	0.870114	0	0
MESDC2	23184	broad.mit.edu	37	15	81282120	81282120	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr15:81282120T>C	ENST00000261758.4	-	1	99	c.13A>G	c.(13-15)Agg>Ggg	p.R5G		NM_015154.1	NP_055969.1	Q14696	MESD_HUMAN	mesoderm development candidate 2	5	Chaperone domain (By similarity).				mesoderm development|protein folding|Wnt receptor signaling pathway	endoplasmic reticulum				cervix(1)|large_intestine(5)|ovary(1)|urinary_tract(1)	8						CGCGCCCACCTGGAAGCCGCC	0.701000													5	6					0	0	0.248553	0	0
ABCA9	10350	broad.mit.edu	37	17	67013849	67013849	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:67013849C>A	ENST00000340001.4	-	21	3060	c.2849G>T	c.(2848-2850)gGc>gTc	p.G950V	ABCA9-AS1_ENST00000458677.1_RNA|ABCA9_ENST00000453985.2_Missense_Mutation_p.G950V|ABCA9_ENST00000370732.2_Missense_Mutation_p.G950V	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	950					transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					GTCATCTGTGCCATTTCTAGT	0.428000													8	740					1.06961e-07	1.17397e-07	0.278610	1	0
SIGLEC16	400709	broad.mit.edu	37	19	50473431	50473431	+	RNA	SNP	T	T	G			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:50473431T>G	ENST00000602139.1	+	0	432									sialic acid binding Ig-like lectin 16 (gene/pseudogene)											endometrium(2)|kidney(2)|lung(6)	10						CGTGAACAATTTGTTCTAAAA	0.547000													6	25					0	0	0.217242	0	0
WDR26	80232	broad.mit.edu	37	1	224592221	224592221	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:224592221C>T	ENST00000414423.2	-	8	1403	c.1210G>A	c.(1210-1212)Gtt>Att	p.V404I	WDR26_ENST00000295024.6_Missense_Mutation_p.V257I|WDR26_ENST00000366852.2_3'UTR	NM_001115113.2|NM_025160.6	NP_001108585.2|NP_079436.4	Q9H7D7	WDR26_HUMAN	WD repeat domain 26	404						cytoplasm|nucleus				biliary_tract(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)	18				GBM - Glioblastoma multiforme(131;0.0104)		ATATAAGAAACGCCATAAGCA	0.413000													5	128					0	0	0.184627	0	0
MMP3	4314	broad.mit.edu	37	11	102713276	102713276	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:102713276C>T	ENST00000299855.5	-	3	641	c.385G>A	c.(385-387)Gct>Act	p.A129T		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	129					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	GAATCAACAGCATCTTTTGGC	0.383000													58	189					0	0	0.870114	0	0
RXRB	6257	broad.mit.edu	37	6	33166123	33166123	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:33166123C>T	ENST00000374680.3	-	3	813	c.602G>A	c.(601-603)gGc>gAc	p.G201D	RXRB_ENST00000374685.4_Missense_Mutation_p.G201D|RXRB_ENST00000413614.2_Missense_Mutation_p.G105D|RXRB_ENST00000544186.1_Missense_Mutation_p.G11D	NM_001270401.1|NM_021976.4	NP_001257330.1|NP_068811.1	P28702	RXRB_HUMAN	retinoid X receptor, beta	201	Modulating (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(1)|skin(2)	15					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Bexarotene(DB00307)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	TAGCCGTTTGCCAGCCCCAGG	0.622000													5	242					0	0	0.217242	0	0
ECSIT	51295	broad.mit.edu	37	19	11617057	11617057	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:11617057G>A	ENST00000270517.7	-	8	1373	c.1238C>T	c.(1237-1239)cCc>cTc	p.P413L	ECSIT_ENST00000591104.1_3'UTR|ECSIT_ENST00000252440.7_3'UTR|ECSIT_ENST00000588998.1_3'UTR|ECSIT_ENST00000417981.2_Missense_Mutation_p.P199L	NM_016581.4	NP_057665.2	Q9BQ95	ECSIT_HUMAN	ECSIT signalling integrator	413					innate immune response|regulation of oxidoreductase activity	mitochondrion	oxidoreductase activity, acting on NADH or NADPH|protein binding			kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	11						GTGGTCCTCGGGCAGGGGCGG	0.701000													51	104					0	0	0.870114	0	0
MKL2	57496	broad.mit.edu	37	16	14345845	14345845	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:14345845C>T	ENST00000571589.1	+	14	2702	c.2530C>T	c.(2530-2532)Cca>Tca	p.P844S	MKL2_ENST00000574045.1_Missense_Mutation_p.P794S|MKL2_ENST00000318282.5_Missense_Mutation_p.P794S|MKL2_ENST00000341243.5_Missense_Mutation_p.P833S	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	833					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TGCTCCGCTTCCATCCCTGCA	0.498000													62	232					0	0	0.870114	0	0
ZCCHC17	51538	broad.mit.edu	37	1	31836952	31836952	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:31836952G>A	ENST00000373714.1	+	8	899	c.638G>A	c.(637-639)gGc>gAc	p.G213D	ZCCHC17_ENST00000546109.1_Missense_Mutation_p.G205D|ZCCHC17_ENST00000422613.2_Missense_Mutation_p.G215D|ZCCHC17_ENST00000344147.5_Missense_Mutation_p.G213D			Q9NP64	NO40_HUMAN	zinc finger, CCHC domain containing 17	213	Lys-rich.					nucleolus	RNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(2)|ovary(1)|skin(1)	6		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)|all_neural(195;0.146)|Medulloblastoma(700;0.151)|Breast(348;0.222)		STAD - Stomach adenocarcinoma(196;0.0215)|READ - Rectum adenocarcinoma(331;0.168)		AGTGATACAGGCAAGAGGGCA	0.393000													5	90					0	0	0.184627	0	0
CYP2D7	1564	broad.mit.edu	37	22	42538870	42538870	+	RNA	SNP	A	A	C	rs2982057	by1000genomes	TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr22:42538870A>C	ENST00000433992.1	-	0	475				CYP2D7P1_ENST00000424775.1_RNA|CYP2D7P1_ENST00000358097.4_RNA																endometrium(1)	1						CCATAGCGCGACAGGAACACC	0.687000													3	16					0	0	0.217242	0	0
CATSPERG	57828	broad.mit.edu	37	19	38853184	38853184	+	Missense_Mutation	SNP	G	G	C			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:38853184G>C	ENST00000409235.3	+	19	2441	c.2326G>C	c.(2326-2328)Ggc>Cgc	p.G776R	CATSPERG_ENST00000215069.4_3'UTR|CATSPERG_ENST00000410018.1_Missense_Mutation_p.G736R	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	776					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						GTCGGCGCAGGGCCACTCGTT	0.642000													6	108					0	0	0.217242	0	0
CPXM1	56265	broad.mit.edu	37	20	2775056	2775056	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr20:2775056C>T	ENST00000380605.2	-	14	2049	c.1985G>A	c.(1984-1986)cGt>cAt	p.R662H		NM_001184699.1|NM_019609.4	NP_001171628.1|NP_062555.1	Q96SM3	CPXM1_HUMAN	carboxypeptidase X (M14 family), member 1	662					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(8)|lung(17)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						GGTCAGCAGACGCCAATAATC	0.602000													4	111					0	0	0.150653	0	0
TNFSF9	8744	broad.mit.edu	37	19	6534882	6534882	+	Silent	SNP	C	C	T			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:6534882C>T	ENST00000245817.3	+	3	608	c.570C>T	c.(568-570)tcC>tcT	p.S190S		NM_003811.3	NP_003802.1	P41273	TNFL9_HUMAN	tumor necrosis factor (ligand) superfamily, member 9	190					apoptosis|cell proliferation|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)|lung(1)|ovary(1)|prostate(1)|skin(1)	5						CCGCCTCCTCCGAGGCTCGGA	0.697000													6	27					0	0	0.248553	0	0
DRD5	1816	broad.mit.edu	37	4	9784063	9784063	+	Missense_Mutation	SNP	A	A	G			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr4:9784063A>G	ENST00000304374.2	+	1	806	c.410A>G	c.(409-411)gAc>gGc	p.D137G		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	137					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane		p.D137G(1)		NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	ATCAGCGTGGACCGCTACTGG	0.612000													3	56					0	0	0.115264	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15586419	15586419	+	Silent	SNP	C	C	T			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:15586419C>T	ENST00000292609.4	-	2	1191	c.1062G>A	c.(1060-1062)caG>caA	p.Q354Q	PGLYRP2_ENST00000340880.4_Silent_p.Q354Q			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	354					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						GGCTCATGCACTGAAGCTGGA	0.582000													25	143					0	0	0.667858	0	0
PRAMEF6	440561	broad.mit.edu	37	1	13109019	13109020	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:13109019_13109020insG	ENST00000376182.1	-	4	1348_1349	c.1249_1250insC	c.(1249-1251)ggafs	p.G417fs	PRAMEF6_ENST00000414205.2_Frame_Shift_Ins_p.G417fs|PRAMEF6_ENST00000376192.5_Intron			Q5VXH4	PRAM6_HUMAN	PRAME family member 6	417										NS(1)|kidney(1)|lung(5)|urinary_tract(2)	9	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ATAACTCTCCCGGGGGGCAGGA	0.520													11	371	---	---	---	---					
PRAMEF26	645359	broad.mit.edu	37	1	13219469	13219470	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:13219469_13219470insT	ENST00000423177.1	-	1	111_112	c.112_113insA	c.(112-114)cagfs	p.Q38fs																	breast(1)|lung(1)	2						TCCTGCACTGGTTTTTTGTTCC	0.505													7	705	---	---	---	---					
RAP1GAP	5909	broad.mit.edu	37	1	21936093	21936094	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:21936093_21936094insG	ENST00000542643.2	-	16	1347_1348	c.1045_1046insC	c.(1045-1047)cccfs	p.P349fs	RAP1GAP_ENST00000374763.2_Frame_Shift_Ins_p.P349fs|RAP1GAP_ENST00000374761.2_Frame_Shift_Ins_p.P380fs|RAP1GAP_ENST00000374765.4_Frame_Shift_Ins_p.P349fs|RAP1GAP_ENST00000290101.4_Frame_Shift_Ins_p.P413fs	NM_001145657.1	NP_001139129.1	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein	349	Rap-GAP.				regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	17		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		GGGGTCCGGGAGGGGGGGTCCA	0.634													7	149	---	---	---	---					
ARID1A	8289	broad.mit.edu	37	1	27105930	27105931	+	Frame_Shift_Ins	INS	-	-	G	rs140055856		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:27105930_27105931insG	ENST00000324856.7	+	20	5912_5913	c.5541_5542insG	c.(5539-5544)ggggggfs	p.GG1847fs	ARID1A_ENST00000457599.2_Frame_Shift_Ins_p.GG1630fs|ARID1A_ENST00000540690.1_Frame_Shift_Ins_p.GG175fs|ARID1A_ENST00000374152.2_Frame_Shift_Ins_p.GG1464fs	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1847					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.G1848fs*6(3)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GGCGGATTGGTGGGGGGGACAC	0.579			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								10	303	---	---	---	---					
KIAA1522	57648	broad.mit.edu	37	1	33233494	33233495	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:33233494_33233495insC	ENST00000401073.2	+	2	412_413	c.342_343insC	c.(340-345)cgccccfs	p.RP114fs	KIAA1522_ENST00000373480.1_Frame_Shift_Ins_p.RP55fs|KIAA1522_ENST00000294521.3_Frame_Shift_Ins_p.RP55fs|KIAA1522_ENST00000373481.3_Frame_Shift_Ins_p.RP66fs	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	55			S -> P (in dbSNP:rs3737994).							breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CCAGTGGGCGACCCCCCCACCT	0.614													11	147	---	---	---	---					
CSF3R	1441	broad.mit.edu	37	1	36935322	36935323	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:36935322_36935323insG	ENST00000373103.1	-	11	1951_1952	c.1404_1405insC	c.(1402-1407)ccgcgcfs	p.R469fs	CSF3R_ENST00000361632.4_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000338937.5_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000440588.2_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000487540.2_5'UTR|CSF3R_ENST00000331941.5_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000418048.2_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000373104.1_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000373106.1_Frame_Shift_Ins_p.R469fs	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	469	Fibronectin type-III 4.				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TTGCTCGCGCTGGGGGGGCCCA	0.634													10	240	---	---	---	---					
BMP8A	353500	broad.mit.edu	37	1	39988691	39988692	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:39988691_39988692insC	ENST00000331593.5	+	6	1307_1308	c.961_962insC	c.(961-963)cccfs	p.P321fs	RP11-69E11.4_ENST00000440190.1_RNA|RP11-69E11.4_ENST00000450157.1_RNA|RP11-69E11.4_ENST00000458207.1_RNA|RP11-69E11.4_ENST00000441741.1_RNA|RP11-69E11.4_ENST00000431553.1_RNA|RP11-69E11.4_ENST00000417869.1_RNA|RP11-69E11.4_ENST00000331856.2_RNA	NM_181809.3	NP_861525.2	Q7Z5Y6	BMP8A_HUMAN	bone morphogenetic protein 8a	321					cartilage development|cell differentiation|growth|ossification	extracellular space	cytokine activity|growth factor activity			kidney(1)|large_intestine(2)|lung(1)|skin(1)	5	Lung NSC(20;2.08e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;9.69e-19)|Epithelial(16;9.34e-17)|all cancers(16;1.73e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTGGGTCATCGCCCCCCAAGGC	0.644													10	223	---	---	---	---					
RNF220	55182	broad.mit.edu	37	1	44878032	44878033	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:44878032_44878033insC	ENST00000355387.2	+	2	713_714	c.263_264insC	c.(262-264)tccfs	p.S88fs	RNF220_ENST00000361799.2_Frame_Shift_Ins_p.S88fs|RNF220_ENST00000372247.2_Frame_Shift_Ins_p.S88fs			Q5VTB9	RN220_HUMAN	ring finger protein 220	88					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	29						AATCGTGATTTCCCCCCTTCTC	0.515													7	958	---	---	---	---					
FAM151A	338094	broad.mit.edu	37	1	55081756	55081757	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:55081756_55081757insG	ENST00000302250.2	-	3	511_512	c.351_352insC	c.(349-354)ccctatfs	p.Y118fs	ACOT11_ENST00000371316.3_Intron|FAM151A_ENST00000371304.2_Frame_Shift_Ins_p.Y118fs	NM_176782.2	NP_788954.2	Q8WW52	F151A_HUMAN	family with sequence similarity 151, member A	118						integral to membrane		p.T118fs*43(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	12						CTGTAGATAGTGGGGGGGTGTG	0.594													16	254	---	---	---	---					
CACHD1	57685	broad.mit.edu	37	1	65157116	65157117	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:65157116_65157117insC	ENST00000371073.2	+	27	3697_3698	c.3697_3698insC	c.(3697-3699)cccfs	p.P1233fs	CACHD1_ENST00000495994.1_3'UTR|CACHD1_ENST00000290039.5_Frame_Shift_Ins_p.P1182fs			Q5VU97	CAHD1_HUMAN	cache domain containing 1	1233					calcium ion transport	integral to membrane		p.Q1185fs*23(1)		breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						AGACCTGGATACCCCCCCTCAG	0.554													7	179	---	---	---	---					
GBP7	388646	broad.mit.edu	37	1	89613321	89613322	+	Frame_Shift_Ins	INS	-	-	C	rs138127555		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:89613321_89613322insC	ENST00000294671.2	-	8	1431_1432	c.1293_1294insG	c.(1291-1296)ggacaafs	p.Q432fs		NM_207398.2	NP_997281.2	Q8N8V2	GBP7_HUMAN	guanylate binding protein 7	432						integral to membrane	GTP binding|GTPase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		TAGATATTGTGCCCCCCCGGAA	0.436													14	172	---	---	---	---					
DENND2D	79961	broad.mit.edu	37	1	111742337	111742338	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:111742337_111742338insC	ENST00000357640.4	-	2	379_380	c.150_151insG	c.(148-153)ggagcafs	p.A51fs	DENND2D_ENST00000369752.5_Frame_Shift_Ins_p.A48fs|DENND2D_ENST00000473682.1_5'UTR	NM_024901.3	NP_079177.2	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	51										breast(1)|endometrium(1)|kidney(7)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		AAGAAGTGCTGCCCCCCAGCAA	0.485													8	211	---	---	---	---					
OVGP1	5016	broad.mit.edu	37	1	111959046	111959047	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:111959046_111959047insC	ENST00000369732.3	-	10	1109_1110	c.1054_1055insG	c.(1054-1056)catfs	p.H352fs	OVGP1_ENST00000540696.1_3'UTR	NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	352					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		CCACACCATGGCCCCCCCAAAA	0.505													27	419	---	---	---	---					
OLFML3	56944	broad.mit.edu	37	1	114523958	114523959	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:114523958_114523959insC	ENST00000369551.1	+	4	1016_1017	c.728_729insC	c.(727-729)accfs	p.T243fs	OLFML3_ENST00000393300.2_Frame_Shift_Ins_p.T243fs|OLFML3_ENST00000491700.1_3'UTR|OLFML3_ENST00000320334.4_Frame_Shift_Ins_p.T263fs			Q9NRN5	OLFL3_HUMAN	olfactomedin-like 3	263	Olfactomedin-like.				multicellular organismal development	extracellular region				breast(1)|endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|skin(2)|urinary_tract(1)	14	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGGGGCTGATCCCCCCCTACG	0.559													9	174	---	---	---	---					
CD101	9398	broad.mit.edu	37	1	117561126	117561127	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:117561126_117561127insC	ENST00000256652.4	+	6	2019_2020	c.1961_1962insC	c.(1960-1962)cccfs	p.P654fs	CD101_ENST00000369470.1_Frame_Shift_Ins_p.P654fs	NM_001256106.1|NM_001256109.1|NM_001256111.1|NM_004258.4	NP_001243035.1|NP_001243038.1|NP_001243040.1|NP_004249.2	Q93033	IGSF2_HUMAN	CD101 molecule	654					cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(14)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TACAACAACCGCCCCCCGAGGG	0.441													7	145	---	---	---	---					
ITGA10	8515	broad.mit.edu	37	1	145534121	145534122	+	Frame_Shift_Ins	INS	-	-	C	rs147270843		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:145534121_145534122insC	ENST00000369304.3	+	14	1801_1802	c.1626_1627insC	c.(1624-1629)gaccccfs	p.DP542fs	ITGA10_ENST00000538811.1_Frame_Shift_Ins_p.DP411fs|ITGA10_ENST00000539363.1_Frame_Shift_Ins_p.DP399fs	NM_003637.3	NP_003628.2	O75578	ITA10_HUMAN	integrin, alpha 10	542					cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			NS(1)|breast(2)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTCAGCCAGAACCCCCCCAGGA	0.554													14	337	---	---	---	---					
PIAS3	10401	broad.mit.edu	37	1	145584022	145584023	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:145584022_145584023insC	ENST00000393045.2	+	10	1343_1344	c.1253_1254insC	c.(1252-1254)tccfs	p.S418fs	PIAS3_ENST00000369298.1_Frame_Shift_Ins_p.S383fs	NM_006099.3	NP_006090.2	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	418					positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)	28	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TCTGAGGTTTGCCCCCCGCCAG	0.500													10	567	---	---	---	---					
ARNT	405	broad.mit.edu	37	1	150784508	150784509	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:150784508_150784509insG	ENST00000358595.5	-	22	2558_2559	c.2358_2359insC	c.(2356-2361)cctttcfs	p.PF786fs	ARNT_ENST00000515192.1_Frame_Shift_Ins_p.PF772fs|ARNT_ENST00000354396.2_Frame_Shift_Ins_p.PF784fs|ARNT_ENST00000505755.1_Frame_Shift_Ins_p.PF771fs	NM_001197325.1|NM_001668.3|NM_178427.2	NP_001184254.1|NP_001659.1|NP_848514.1	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	786					positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|prostate(2)|skin(4)|stomach(1)	34	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			TATTCTGAAAAGGGGGGAAACA	0.376			T	ETV6	AML								8	196	---	---	---	---					
IGSF9	57549	broad.mit.edu	37	1	159904586	159904587	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:159904586_159904587insG	ENST00000368094.1	-	7	896_897	c.699_700insC	c.(697-702)ccagaafs	p.E234fs	IGSF9_ENST00000361509.3_Frame_Shift_Ins_p.E234fs	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	234	Ig-like 3.					cell junction|integral to membrane|synapse				central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GTGCTGTTCTTGGGGGGCACCA	0.569													10	326	---	---	---	---					
TNN	63923	broad.mit.edu	37	1	175096158	175096159	+	Frame_Shift_Ins	INS	-	-	C	rs59588723	byFrequency	TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:175096158_175096159insC	ENST00000239462.4	+	13	3095_3096	c.2982_2983insC	c.(2980-2985)acccccfs	p.TP994fs		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	994	Fibronectin type-III 9.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TGACCTGGACGCCCCCCTCTGC	0.505													8	416	---	---	---	---					
PAPPA2	60676	broad.mit.edu	37	1	176762723	176762724	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:176762723_176762724insC	ENST00000367662.3	+	20	6212_6213	c.5048_5049insC	c.(5047-5049)accfs	p.T1683fs		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1683	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TTGTGTGTAATCCCCCCCAGTG	0.470													23	448	---	---	---	---					
CR2	1380	broad.mit.edu	37	1	207642043	207642044	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:207642043_207642044insC	ENST00000367057.3	+	3	806_807	c.617_618insC	c.(616-618)gccfs	p.A206fs	CR2_ENST00000367059.3_Frame_Shift_Ins_p.A206fs|CR2_ENST00000458541.2_Frame_Shift_Ins_p.A206fs|CR2_ENST00000367058.3_Frame_Shift_Ins_p.A206fs|CR2_ENST00000485707.1_3'UTR	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	206	Sushi 3.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity	p.T209fs*10(1)		NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						TGGAGTGCTGTCCCCCCCACAT	0.396													9	375	---	---	---	---					
SIPA1L2	57568	broad.mit.edu	37	1	232650637	232650638	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:232650637_232650638insG	ENST00000366630.1	-	2	806_807	c.448_449insC	c.(448-450)aagfs	p.K150fs	SIPA1L2_ENST00000262861.4_Frame_Shift_Ins_p.K150fs			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	150					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				AAGTCCTCTTTGGGGGGAATGG	0.490													7	503	---	---	---	---					
HS1BP3	64342	broad.mit.edu	37	2	20840863	20840864	+	Frame_Shift_Ins	INS	-	-	G	rs77941615	byFrequency	TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:20840863_20840864insG	ENST00000402541.1	-	3	289_290	c.275_276insC	c.(274-276)cctfs	p.P92fs	HS1BP3_ENST00000406618.3_Frame_Shift_Ins_p.P92fs|HS1BP3_ENST00000304031.3_Frame_Shift_Ins_p.P92fs			Q53T59	H1BP3_HUMAN	HCLS1 binding protein 3	92	PX.				cell communication		phosphatidylinositol binding			endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	15	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCTGGGTAGTGGGGGGAGGCT	0.540													8	415	---	---	---	---					
DCTN1	1639	broad.mit.edu	37	2	74593376	74593377	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:74593376_74593377insG	ENST00000361874.3	-	23	3071_3072	c.2754_2755insC	c.(2752-2757)ccgcaafs	p.Q919fs	DCTN1_ENST00000409240.1_Frame_Shift_Ins_p.Q882fs|DCTN1_ENST00000409868.1_Frame_Shift_Ins_p.Q902fs|DCTN1_ENST00000407639.2_Frame_Shift_Ins_p.Q785fs|DCTN1_ENST00000409438.1_Frame_Shift_Ins_p.Q785fs|DCTN1_ENST00000495643.1_5'UTR|DCTN1_ENST00000409567.3_Frame_Shift_Ins_p.Q899fs|DCTN1_ENST00000394003.3_Frame_Shift_Ins_p.Q912fs	NM_004082.4	NP_004073.2	Q14203	DCTN1_HUMAN	dynactin 1	919					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(1)|skin(3)	45						CCTACCTTGCTGGGGGGCCGCT	0.559													8	573	---	---	---	---					
SEMA4F	10505	broad.mit.edu	37	2	74906845	74906846	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:74906845_74906846insC	ENST00000357877.2	+	14	1971_1972	c.1822_1823insC	c.(1822-1824)cccfs	p.P608fs	SEMA4F_ENST00000339773.5_Frame_Shift_Ins_p.P453fs|SEMA4F_ENST00000473350.1_3'UTR	NM_004263.3	NP_004254.2	O95754	SEM4F_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F	608	Ig-like C2-type.				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			biliary_tract(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(2)	45						GACTGCACTCACCCCCCGGCGG	0.629													8	209	---	---	---	---					
EDAR	10913	broad.mit.edu	37	2	109539836	109539837	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:109539836_109539837insG	ENST00000409271.1	-	6	872_873	c.429_430insC	c.(427-432)ccacacfs	p.H144fs	EDAR_ENST00000376651.1_Frame_Shift_Ins_p.H144fs|EDAR_ENST00000258443.2_Frame_Shift_Ins_p.H144fs			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor	144					apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						TCCTTGGTGTTGGGGGGTGCCA	0.535													7	264	---	---	---	---					
MCM6	4175	broad.mit.edu	37	2	136622724	136622725	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:136622724_136622725insC	ENST00000264156.2	-	7	996_997	c.936_937insG	c.(934-939)ggaagafs	p.R313fs		NM_005915.5	NP_005906.2	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	313					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(15)|prostate(2)|skin(1)	29				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	CTGAGCTCTTTCCCCCCAAACT	0.376													7	320	---	---	---	---					
KCNH7	90134	broad.mit.edu	37	2	163256860	163256861	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:163256860_163256861insC	ENST00000332142.5	-	10	2344_2345	c.2245_2246insG	c.(2245-2247)aagfs	p.K749fs		NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	749					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity	p.A749fs*3(1)		NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	ACCTTTACTTGCCCCCCGAAAG	0.485													7	346	---	---	---	---					
XIRP2	129446	broad.mit.edu	37	2	168099957	168099958	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:168099957_168099958insG	ENST00000409195.1	+	9	2144_2145	c.2055_2056insG	c.(2053-2058)acggggfs	p.TG685fs	XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409273.1_Frame_Shift_Ins_p.TG463fs|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Frame_Shift_Ins_p.TG685fs|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	510					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AGGACATAACTGGGGGGGATGT	0.421													12	226	---	---	---	---					
MYO3B	140469	broad.mit.edu	37	2	171240258	171240259	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:171240258_171240259insC	ENST00000334231.6	+	12	1251_1252	c.1251_1252insC	c.(1249-1254)aaccccfs	p.NP417fs	MYO3B_ENST00000408978.4_Frame_Shift_Ins_p.NP408fs|MYO3B_ENST00000602629.1_3'UTR|MYO3B_ENST00000409044.3_Frame_Shift_Ins_p.NP408fs			Q8WXR4	MYO3B_HUMAN	myosin IIIB	408	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						GCGCCTCCAATCCCCCCCACAT	0.465													7	232	---	---	---	---					
RQCD1	9125	broad.mit.edu	37	2	219449363	219449364	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:219449363_219449364insT	ENST00000273064.6	+	4	724_725	c.349_350insT	c.(349-351)tttfs	p.F117fs	RQCD1_ENST00000295701.5_Frame_Shift_Ins_p.F117fs|RQCD1_ENST00000542068.1_Frame_Shift_Ins_p.F117fs|RQCD1_ENST00000509807.2_Frame_Shift_Ins_p.F117fs	NM_005444.2	NP_005435.1	Q92600	RCD1_HUMAN	RCD1 required for cell differentiation1 homolog (S. pombe)	117					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|sex differentiation|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|prostate(3)|skin(1)	15		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000192)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACACATCCCACTTTTTTTGTAC	0.416													7	587	---	---	---	---					
NDUFA10	4705	broad.mit.edu	37	2	240954220	240954221	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr2:240954220_240954221insG	ENST00000252711.2	-	5	704_705	c.604_605insC	c.(604-606)cctfs	p.P202fs	NDUFA10_ENST00000307300.4_Frame_Shift_Ins_p.P242fs|NDUFA10_ENST00000404554.1_Frame_Shift_Ins_p.P202fs	NM_004544.3	NP_004535.1	O95299	NDUAA_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa	202					mitochondrial electron transport, NADH to ubiquinone|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transport	mitochondrial matrix|mitochondrial respiratory chain complex I	ATP binding|NADH dehydrogenase (ubiquinone) activity|phosphotransferase activity, alcohol group as acceptor			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)	16		all_epithelial(40;4.26e-15)|Breast(86;4.4e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(121;7.82e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.5e-13)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.39e-05)|Lung(119;0.00519)|LUSC - Lung squamous cell carcinoma(224;0.0202)	NADH(DB00157)	AATCACCAGGTGGGGGGGCAGG	0.535													7	304	---	---	---	---					
THUMPD3	25917	broad.mit.edu	37	3	9413160	9413161	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:9413160_9413161insG	ENST00000345094.3	+	4	1081_1082	c.747_748insG	c.(745-750)ttggggfs	p.LG249fs	THUMPD3_ENST00000515662.2_Frame_Shift_Ins_p.LG249fs|THUMPD3_ENST00000452837.2_Frame_Shift_Ins_p.LG249fs|SETD5-AS1_ENST00000468186.1_RNA	NM_001114092.1|NM_015453.2	NP_001107564.1|NP_056268.2	Q9BV44	THUM3_HUMAN	THUMP domain containing 3	249	THUMP.						methyltransferase activity|protein binding|RNA binding			NS(1)|central_nervous_system(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	19	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.101)		CAAGAGATTTTGGGGGTGCTGT	0.446													7	505	---	---	---	---					
SETD5	55209	broad.mit.edu	37	3	9517294	9517295	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:9517294_9517295insC	ENST00000402466.1	+	24	4322_4323	c.3554_3555insC	c.(3553-3555)accfs	p.T1185fs	SETD5_ENST00000407969.1_Frame_Shift_Ins_p.T1302fs|SETD5_ENST00000406341.1_Frame_Shift_Ins_p.T1283fs|SETD5_ENST00000302463.6_Frame_Shift_Ins_p.T1185fs|SETD5_ENST00000402198.1_Frame_Shift_Ins_p.T1283fs			Q9C0A6	SETD5_HUMAN	SET domain containing 5	1283	Ser-rich.									NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		AGACCTGGAAACCCCCCCTCTC	0.550													9	310	---	---	---	---					
MLH1	4292	broad.mit.edu	37	3	37070348	37070349	+	Frame_Shift_Ins	INS	-	-	C	rs63750855		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:37070348_37070349insC	ENST00000231790.2	+	13	1699_1700	c.1483_1484insC	c.(1483-1485)cccfs	p.P495fs	MLH1_ENST00000536378.1_Frame_Shift_Ins_p.P254fs|MLH1_ENST00000539477.1_Frame_Shift_Ins_p.P254fs|MLH1_ENST00000435176.1_Frame_Shift_Ins_p.P397fs|MLH1_ENST00000458205.2_Frame_Shift_Ins_p.P254fs|MLH1_ENST00000455445.2_Frame_Shift_Ins_p.P254fs	NM_000249.3|NM_001258273.1	NP_000240.1|NP_001245202.1	P40692	MLH1_HUMAN	mutL homolog 1	495	Interaction with EXO1.				mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.T495A(1)|p.0?(1)		NS(1)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(54)|lung(13)|oesophagus(7)|ovary(6)|pancreas(5)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	127						TGCAGCTTGTACCCCCCGGAGA	0.470		1	"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian, CNS"""	"""colorectal, endometrial, ovarian, CNS"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				12	857	---	---	---	---					
TREX1	11277	broad.mit.edu	37	3	48508191	48508192	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:48508191_48508192insC	ENST00000296443.9	+	3	1024_1025	c.137_138insC	c.(136-138)accfs	p.T46fs	TREX1_ENST00000492235.1_3'UTR|TREX1_ENST00000436480.2_Frame_Shift_Ins_p.T46fs|TREX1_ENST00000444177.1_Frame_Shift_Ins_p.T36fs|TREX1_ENST00000433541.1_5'UTR|TREX1_ENST00000456089.1_Intron|TREX1_ENST00000422277.2_Frame_Shift_Ins_p.T101fs			Q9NSU2	TREX1_HUMAN	three prime repair exonuclease 1	101					cell death|DNA recombination|DNA replication|mismatch repair	nuclear envelope	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|metal ion binding|MutLalpha complex binding|MutSalpha complex binding|protein homodimerization activity|single-stranded DNA binding			breast(1)|kidney(1)|large_intestine(1)|lung(3)|skin(3)	9				BRCA - Breast invasive adenocarcinoma(193;0.000286)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		GCCCTGGAGAGCCCCCCCACCT	0.644													7	209	---	---	---	---					
IL17RB	55540	broad.mit.edu	37	3	53898813	53898814	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:53898813_53898814insC	ENST00000288167.3	+	11	996_997	c.987_988insC	c.(985-990)ctccccfs	p.LP329fs		NM_018725.3	NP_061195.2	Q9NRM6	I17RB_HUMAN	interleukin 17 receptor B	329					defense response|regulation of cell growth	extracellular region|integral to plasma membrane	cytokine receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)		CCACACTACTGCCCCCCATTAA	0.406													7	743	---	---	---	---					
ATXN7	6314	broad.mit.edu	37	3	63981831	63981832	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:63981831_63981832insC	ENST00000398590.3	+	12	2886_2887	c.2333_2334insC	c.(2332-2334)gccfs	p.A778fs	ATXN7_ENST00000487717.1_Frame_Shift_Ins_p.A778fs|ATXN7_ENST00000484332.1_Frame_Shift_Ins_p.A633fs|ATXN7_ENST00000538065.1_Frame_Shift_Ins_p.A778fs|ATXN7_ENST00000295900.6_Frame_Shift_Ins_p.A778fs	NM_001177387.1	NP_001170858.1	O15265	ATX7_HUMAN	ataxin 7	778	Ser-rich.				cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(12)|prostate(2)|stomach(1)|urinary_tract(3)	35		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		TCAGGGAGGGGCCCCCCCACCG	0.545													14	202	---	---	---	---					
MORC1	27136	broad.mit.edu	37	3	108819313	108819314	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:108819313_108819314insT	ENST00000232603.5	-	5	346_347	c.264_265insA	c.(262-267)aaggctfs	p.A89fs	MORC1_ENST00000483760.1_Frame_Shift_Ins_p.A89fs	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	89					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding	p.R89W(1)		breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						GTTGACAGCCGTTTTTTGGATC	0.406													14	1228	---	---	---	---					
MUC13	56667	broad.mit.edu	37	3	124646628	124646629	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:124646628_124646629insG	ENST00000311075.3	-	2	299_300	c.261_262insC	c.(259-264)cctaatfs	p.N88fs		NM_033049.3	NP_149038.3	Q9H3R2	MUC13_HUMAN	mucin 13, cell surface associated	88	Thr-rich.					extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(1)|stomach(1)	18						GTACTAATTATGGGGGGAGCAG	0.441													8	1461	---	---	---	---					
TRH	7200	broad.mit.edu	37	3	129695642	129695643	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:129695642_129695643insG	ENST00000302649.3	+	3	839_840	c.312_313insG	c.(310-315)gaggggfs	p.EG104fs	TRH_ENST00000507066.1_Frame_Shift_Ins_p.EG100fs	NM_007117.3	NP_009048.1	P20396	TRH_HUMAN	thyrotropin-releasing hormone	104					cell-cell signaling|hormone-mediated signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|thyrotropin-releasing hormone activity			NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)	14						aagaggaagaagggggggCTGT	0.569													10	263	---	---	---	---					
PIK3CB	5291	broad.mit.edu	37	3	138413709	138413710	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:138413709_138413710insG	ENST00000477593.1	-	13	1883_1884	c.1810_1811insC	c.(1810-1812)ggafs	p.G604fs	PIK3CB_ENST00000289153.2_Frame_Shift_Ins_p.G604fs|PIK3CB_ENST00000544716.1_Frame_Shift_Ins_p.G50fs			P42338	PK3CB_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	604	PI3K helical.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						TAGGGCCTCCCGGGGGGGCAGT	0.465													10	181	---	---	---	---					
GRK7	131890	broad.mit.edu	37	3	141535707	141535708	+	Frame_Shift_Ins	INS	-	-	G	rs149574289		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:141535707_141535708insG	ENST00000264952.2	+	4	1614_1615	c.1477_1478insG	c.(1477-1479)gggfs	p.G493fs		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	493	AGC-kinase C-terminal.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity	p.R493L(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						CTCTGAGGTTCGGGGGGTGGAA	0.460													10	1216	---	---	---	---					
SAMD7	344658	broad.mit.edu	37	3	169646267	169646268	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:169646267_169646268insG	ENST00000428432.2	+	7	1331_1332	c.942_943insG	c.(940-945)atggggfs	p.MG314fs	SAMD7_ENST00000335556.3_Frame_Shift_Ins_p.MG314fs	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	314										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			TGGTTACAATTGGGGGGAATCT	0.381													9	607	---	---	---	---					
FNDC3B	64778	broad.mit.edu	37	3	172096209	172096210	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:172096209_172096210insC	ENST00000336824.4	+	24	3257_3258	c.3158_3159insC	c.(3157-3159)gccfs	p.A1053fs	FNDC3B_ENST00000416957.1_Frame_Shift_Ins_p.A1053fs|FNDC3B_ENST00000415807.2_Frame_Shift_Ins_p.A1053fs	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	1053						endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		ACCAAAAGTGTCCCCCCCACCA	0.470													8	201	---	---	---	---					
FGF12	2257	broad.mit.edu	37	3	192053255	192053256	+	Splice_Site	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:192053255_192053256insG	ENST00000454309.2	-	3	1136		c.e3-2		FGF12_ENST00000430714.1_Splice_Site|FGF12_ENST00000445105.1_Splice_Site|FGF12_ENST00000450716.1_Splice_Site|FGF12_ENST00000264730.3_Splice_Site	NM_021032.4	NP_066360.1	P61328	FGF12_HUMAN	fibroblast growth factor 12						cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		TGAAGAGAGCTGGGGGGAGAAA	0.426													8	372	---	---	---	---					
KIAA0226	9711	broad.mit.edu	37	3	197427914	197427915	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr3:197427914_197427915insG	ENST00000273582.5	-	7	1195_1196	c.650_651insC	c.(649-651)cgtfs	p.R217fs	KIAA0226_ENST00000296343.5_Frame_Shift_Ins_p.R277fs|KIAA0226_ENST00000389665.5_Frame_Shift_Ins_p.R277fs|KIAA0226_ENST00000449205.1_Frame_Shift_Ins_p.R277fs	NM_001145642.2	NP_001139114.1	Q92622	RUBIC_HUMAN	KIAA0226	277	Ser-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding			NS(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		AGACTGAAACTGGGGGGGCTTG	0.554													8	192	---	---	---	---					
PDE6B	5158	broad.mit.edu	37	4	619787	619788	+	Frame_Shift_Ins	INS	-	-	C	rs28414606	byFrequency	TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr4:619787_619788insC	ENST00000255622.6	+	1	415_416	c.372_373insC	c.(370-375)gtccccfs	p.VP124fs	PDE6B_ENST00000496514.1_Frame_Shift_Ins_p.VP124fs	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	124	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						ACTGCCTGGTGCCCCCCGACTC	0.658													2	4	---	---	---	---					
FAM193A	8603	broad.mit.edu	37	4	2661592	2661593	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr4:2661592_2661593insC	ENST00000324666.5	+	8	1034_1035	c.683_684insC	c.(682-684)gccfs	p.A228fs	FAM193A_ENST00000382839.3_Frame_Shift_Ins_p.A228fs|FAM193A_ENST00000502458.1_Frame_Shift_Ins_p.A252fs|FAM193A_ENST00000505311.1_Frame_Shift_Ins_p.A228fs|FAM193A_ENST00000545951.1_Frame_Shift_Ins_p.A228fs	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	228										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						GGTATCATGGACCCCCCCGTCA	0.525													10	432	---	---	---	---					
HPGDS	27306	broad.mit.edu	37	4	95223320	95223321	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr4:95223320_95223321insC	ENST00000295256.5	-	5	501_502	c.411_412insG	c.(409-414)gggagafs	p.R138fs		NM_014485.2	NP_055300.1	O60760	HPGDS_HUMAN	hematopoietic prostaglandin D synthase	138	GST C-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity			breast(1)|cervix(1)|lung(3)|ovary(1)|urinary_tract(1)	7					Glutathione(DB00143)	AGCCATTCTCTCCCCCCTAAAT	0.351													8	682	---	---	---	---					
UNC5C	8633	broad.mit.edu	37	4	96140293	96140294	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr4:96140293_96140294insG	ENST00000453304.1	-	9	1819_1820	c.1471_1472insC	c.(1471-1473)agafs	p.R491fs	UNC5C_ENST00000506749.1_Frame_Shift_Ins_p.R510fs	NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	491					apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GAGGTCATCTTGGGGGGTGACA	0.505													12	458	---	---	---	---					
GAB1	2549	broad.mit.edu	37	4	144381536	144381537	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr4:144381536_144381537insC	ENST00000262995.4	+	9	2216_2217	c.1789_1790insC	c.(1789-1791)cccfs	p.P597fs	GAB1_ENST00000505913.1_Frame_Shift_Ins_p.P464fs|GAB1_ENST00000262994.4_Frame_Shift_Ins_p.P567fs	NM_207123.2	NP_997006.1	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1	567					cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(3)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	30	all_hematologic(180;0.158)					GTTTCCCATGTCCCCCCGACCA	0.406													7	326	---	---	---	---					
SORBS2	8470	broad.mit.edu	37	4	186515043	186515044	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr4:186515043_186515044insC	ENST00000431808.1	-	20	3693_3694	c.3130_3131insG	c.(3130-3132)accfs	p.T1044fs	SORBS2_ENST00000418609.1_Frame_Shift_Ins_p.T948fs|SORBS2_ENST00000393528.3_Frame_Shift_Ins_p.T610fs|SORBS2_ENST00000355634.5_Frame_Shift_Ins_p.T1144fs|SORBS2_ENST00000319471.9_Frame_Shift_Ins_p.T675fs|SORBS2_ENST00000284776.7_Frame_Shift_Ins_p.T1044fs|SORBS2_ENST00000449407.2_Frame_Shift_Ins_p.T588fs|SORBS2_ENST00000448662.2_Frame_Shift_Ins_p.T605fs|RP11-301L8.2_ENST00000411847.1_RNA|SORBS2_ENST00000437304.2_Frame_Shift_Ins_p.T768fs			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	1044	SH3 3.					actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding	p.E1044fs*8(2)|p.E605fs*8(2)		endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TACTTACGGTTCCCCCCCACCT	0.356													8	155	---	---	---	---					
TLR3	7098	broad.mit.edu	37	4	186997804	186997805	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr4:186997804_186997805insG	ENST00000296795.2	+	2	135_136	c.31_32insG	c.(31-33)gggfs	p.G11fs		NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3	11					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		TATCTACTTTTGGGGGGGCCTT	0.446													7	201	---	---	---	---					
KLKB1	3818	broad.mit.edu	37	4	187178498	187178499	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr4:187178498_187178499insG	ENST00000264690.6	+	14	1891_1892	c.1704_1705insG	c.(1702-1707)gaggggfs	p.EG568fs	KLKB1_ENST00000513864.1_Intron	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	568	Peptidase S1.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		GCTATAAAGAAGGGGGAAAAGA	0.322													7	294	---	---	---	---					
MYO10	4651	broad.mit.edu	37	5	16694605	16694606	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:16694605_16694606insC	ENST00000513610.1	-	27	4128_4129	c.3674_3675insG	c.(3673-3675)gtcfs	p.V1225fs	MYO10_ENST00000505695.1_Frame_Shift_Ins_p.V564fs|MYO10_ENST00000515803.1_Frame_Shift_Ins_p.V564fs|MYO10_ENST00000274203.9_Frame_Shift_Ins_p.V582fs|MYO10_ENST00000427430.2_Frame_Shift_Ins_p.V582fs	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	1225	PH 1.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity	p.S1226fs*25(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						GCGTGGAGGAGCCCCCCCCTTT	0.564													23	226	---	---	---	---					
C5orf42	65250	broad.mit.edu	37	5	37108532	37108533	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:37108532_37108533insT	ENST00000274258.7	-	51	9560_9561	c.5973_5974insA	c.(5971-5976)aaatggfs	p.W1992fs	C5orf42_ENST00000508244.1_Frame_Shift_Ins_p.W3094fs|C5orf42_ENST00000425232.2_Frame_Shift_Ins_p.W3094fs			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	3094										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			GCACTTCCATGTTTTTTTGTAT	0.431													10	530	---	---	---	---					
FYB	2533	broad.mit.edu	37	5	39202090	39202091	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:39202090_39202091insC	ENST00000351578.6	-	2	1162_1163	c.972_973insG	c.(970-975)ggcatgfs	p.M325fs	FYB_ENST00000512982.1_Frame_Shift_Ins_p.M325fs|FYB_ENST00000540520.1_Frame_Shift_Ins_p.M335fs|FYB_ENST00000505428.1_Frame_Shift_Ins_p.M325fs|FYB_ENST00000515010.1_Frame_Shift_Ins_p.M325fs	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	325					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding	p.P325A(3)|p.P335A(1)		endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			TGGCCCCATGGCCCCCCCACTG	0.540													13	258	---	---	---	---					
C6	729	broad.mit.edu	37	5	41181559	41181560	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:41181559_41181560insC	ENST00000263413.3	-	7	1092_1093	c.828_829insG	c.(826-831)gggctcfs	p.L277fs	C6_ENST00000337836.5_Frame_Shift_Ins_p.L277fs|C6_ENST00000475349.1_5'UTR	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	277	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CTGAAAGAGCTCCCCCCCTGAC	0.376													7	215	---	---	---	---					
MOCS2	4338	broad.mit.edu	37	5	52402939	52402940	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:52402939_52402940insG	ENST00000361377.4	-	3	293_294	c.252_253insC	c.(250-255)ccttagfs	p.*85fs	MOCS2_ENST00000396954.3_Frame_Shift_Ins_p.L22fs|MOCS2_ENST00000508922.1_Frame_Shift_Ins_p.*85fs|MOCS2_ENST00000450852.3_Frame_Shift_Ins_p.*85fs|MOCS2_ENST00000584946.1_Frame_Shift_Ins_p.*85fs|MOCS2_ENST00000510818.2_Frame_Shift_Ins_p.*85fs|MOCS2_ENST00000582677.1_Frame_Shift_Ins_p.*85fs			O96033	MOC2A_HUMAN	molybdenum cofactor synthesis 2	85					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex	nucleotide binding			endometrium(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	5		Lung NSC(810;3.08e-05)|Breast(144;0.0848)				CCTCCACTAATGGGGGGGATAA	0.426													8	198	---	---	---	---					
MAP1B	4131	broad.mit.edu	37	5	71495076	71495077	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:71495076_71495077insC	ENST00000296755.7	+	5	6192_6193	c.5894_5895insC	c.(5893-5895)accfs	p.T1965fs		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1965						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AAGACCACCAGCCCCCCCGAAG	0.485													8	401	---	---	---	---					
GCNT4	51301	broad.mit.edu	37	5	74324982	74324983	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:74324982_74324983insG	ENST00000322348.4	-	1	1741_1742	c.880_881insC	c.(880-882)taafs	p.*294fs		NM_016591.2	NP_057675.1	Q9P109	GCNT4_HUMAN	glucosaminyl (N-acetyl) transferase 4, core 2	294					protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	p.H294fs*2(1)		NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|skin(1)|stomach(2)	19		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		CTGAATGTTATGGGGGGGTGCT	0.366													11	207	---	---	---	---					
EDIL3	10085	broad.mit.edu	37	5	83360606	83360607	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:83360606_83360607insG	ENST00000296591.5	-	8	1282_1283	c.864_865insC	c.(862-867)cctaaafs	p.K289fs	EDIL3_ENST00000380138.3_Frame_Shift_Ins_p.K279fs|EDIL3_ENST00000510271.1_5'UTR	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	289	F5/8 type C 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		TGAGCTTTTATGGGGGGTGTGA	0.391													7	318	---	---	---	---					
ARRDC3	57561	broad.mit.edu	37	5	90667241	90667243	+	In_Frame_Del	DEL	ATC	ATC	-			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:90667241_90667243delATC	ENST00000265138.3	-	8	1485_1487	c.1219_1221delGAT	c.(1219-1221)del	p.D407del		NM_020801.2	NP_065852.1	Q96B67	ARRD3_HUMAN	arrestin domain containing 3	407					signal transduction	cytoplasm	protein binding			breast(2)|endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	18		all_cancers(142;2.22e-05)|all_epithelial(76;1.58e-07)|all_lung(232;0.000521)|Lung NSC(167;0.000548)|Ovarian(174;0.0798)|Colorectal(57;0.207)		OV - Ovarian serous cystadenocarcinoma(54;4.56e-30)|Epithelial(54;7.55e-26)|all cancers(79;3.63e-22)		AGGATGGTCTATCATCTGCTGAC	0.414													10	128	---	---	---	---					
FBN2	2201	broad.mit.edu	37	5	127610310	127610311	+	Frame_Shift_Ins	INS	-	-	C	rs151053868		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:127610310_127610311insC	ENST00000508053.1	-	66	8633_8634	c.7659_7660insG	c.(7657-7662)ggttacfs	p.Y2554fs	FBN2_ENST00000262464.4_Frame_Shift_Ins_p.Y2554fs			P35556	FBN2_HUMAN	fibrillin 2	2554	EGF-like 43; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTACAGGTAAACCCCCCCAGGG	0.421													12	358	---	---	---	---					
FBN2	2201	broad.mit.edu	37	5	127648336	127648337	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:127648336_127648337insG	ENST00000508053.1	-	43	5842_5843	c.4868_4869insC	c.(4867-4869)cgtfs	p.R1623fs	FBN2_ENST00000262464.4_Frame_Shift_Ins_p.R1623fs			P35556	FBN2_HUMAN	fibrillin 2	1623	TB 6.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent	p.P1623P(2)		NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGCTATTGACAGGGGGGCATGT	0.505													10	1156	---	---	---	---					
SLC22A5	6584	broad.mit.edu	37	5	131722730	131722731	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:131722730_131722731insC	ENST00000245407.3	+	5	1059_1060	c.838_839insC	c.(838-840)cccfs	p.P280fs	SLC22A5_ENST00000435065.2_Frame_Shift_Ins_p.P304fs	NM_003060.3	NP_003051.1	O76082	S22A5_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 5	280					positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|stomach(1)	8		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	CATCCCTGAGTCCCCCCGATGG	0.545											OREG0016767	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	917	---	---	---	---					
SLC25A48	153328	broad.mit.edu	37	5	135207263	135207264	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:135207263_135207264insG	ENST00000274513.5	+	5	707_708	c.535_536insG	c.(535-537)gggfs	p.G179fs	SLC25A48_ENST00000412661.2_Intron|SLC25A48_ENST00000433282.2_Frame_Shift_Ins_p.G125fs|SLC25A48_ENST00000420621.1_Frame_Shift_Ins_p.G179fs|SLC25A48_ENST00000425402.1_Intron			Q6ZT89	S2548_HUMAN	solute carrier family 25, member 48	179					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	10						GGGGCTATACCGGGGGGCCAGT	0.604													8	378	---	---	---	---					
EGR1	1958	broad.mit.edu	37	5	137803131	137803132	+	Frame_Shift_Ins	INS	-	-	C	rs148475837		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:137803131_137803132insC	ENST00000239938.4	+	2	1265_1266	c.993_994insC	c.(991-996)acccccfs	p.TP331fs		NM_001964.2	NP_001955.1	P18146	EGR1_HUMAN	early growth response 1	331					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CCAGCAAGACGCCCCCCCACGA	0.649													8	160	---	---	---	---					
PCDHB12	56124	broad.mit.edu	37	5	140588663	140588664	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:140588663_140588664insG	ENST00000239450.2	+	1	373_374	c.184_185insG	c.(184-186)gggfs	p.G62fs	PCDHB12_ENST00000541609.1_Intron	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		62	Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGTCTTCGCGGGGGGCTCGG	0.510													8	191	---	---	---	---					
PCDHGC4	56098	broad.mit.edu	37	5	140865128	140865129	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:140865128_140865129insC	ENST00000306593.1	+	1	388_389	c.388_389insC	c.(388-390)cccfs	p.P130fs	PCDHGA11_ENST00000398587.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron	NM_018928.2|NM_032406.1	NP_061751.1|NP_115782.1														NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(13)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	42			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAATGATCACGCCCCCCGTTTT	0.574													8	437	---	---	---	---					
ARAP3	64411	broad.mit.edu	37	5	141049341	141049342	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:141049341_141049342insC	ENST00000239440.4	-	16	2351_2352	c.2286_2287insG	c.(2284-2289)ggggatfs	p.D763fs	ARAP3_ENST00000513878.1_Frame_Shift_Ins_p.D425fs|ARAP3_ENST00000508305.1_Frame_Shift_Ins_p.D665fs	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	763					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						TGCTGGATCCTCCCCCCAGCGA	0.579													15	766	---	---	---	---					
ARAP3	64411	broad.mit.edu	37	5	141049509	141049510	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:141049509_141049510insG	ENST00000239440.4	-	15	2293_2294	c.2228_2229insC	c.(2227-2229)cccfs	p.P743fs	ARAP3_ENST00000513878.1_Frame_Shift_Ins_p.P405fs|ARAP3_ENST00000508305.1_Frame_Shift_Ins_p.P645fs	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	743					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						GGTCAGTGGGTGGGGGGCTCAC	0.564													11	800	---	---	---	---					
PCDH12	51294	broad.mit.edu	37	5	141336747	141336748	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:141336747_141336748insG	ENST00000231484.3	-	1	1879_1880	c.669_670insC	c.(667-672)ccagtcfs	p.V224fs		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	224	Cadherin 2.				neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTACCTGACTTGGGGGGGTTCC	0.480													21	418	---	---	---	---					
ARHGAP26	23092	broad.mit.edu	37	5	142586762	142586763	+	Splice_Site	INS	-	-	C	rs144777273		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:142586762_142586763insC	ENST00000378004.3	+	21	2343_2344		c.e21-1		ARHGAP26_ENST00000274498.4_Splice_Site|ARHGAP26_ENST00000486650.1_Intron	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26						actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding	p.?(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATGTCTTGCAGCCCCCCGAATC	0.579													12	457	---	---	---	---					
PPP2R2B	5521	broad.mit.edu	37	5	145969651	145969652	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:145969651_145969652insC	ENST00000394413.3	-	9	1760_1761	c.1190_1191insG	c.(1189-1191)gaafs	p.E397fs	PPP2R2B_ENST00000356826.3_Frame_Shift_Ins_p.E397fs|PPP2R2B_ENST00000394414.1_Frame_Shift_Ins_p.E463fs|PPP2R2B_ENST00000453001.1_Frame_Shift_Ins_p.E397fs|PPP2R2B_ENST00000394410.2_Frame_Shift_Ins_p.E386fs|PPP2R2B_ENST00000508545.2_Frame_Shift_Ins_p.E386fs|PPP2R2B_ENST00000504198.1_Frame_Shift_Ins_p.E403fs|PPP2R2B_ENST00000530902.1_5'UTR|PPP2R2B_ENST00000394411.4_Frame_Shift_Ins_p.E397fs|PPP2R2B_ENST00000394409.3_Frame_Shift_Ins_p.E455fs|CTB-99A3.1_ENST00000512730.1_RNA|PPP2R2B_ENST00000336640.6_Frame_Shift_Ins_p.E400fs			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta	397					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCTCCGCTTGCCCCCCACACA	0.500													13	712	---	---	---	---					
HRH2	3274	broad.mit.edu	37	5	175111290	175111291	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:175111290_175111291insC	ENST00000231683.2	+	1	2827_2828	c.1054_1055insC	c.(1054-1056)cccfs	p.P352fs	HRH2_ENST00000377291.2_Frame_Shift_Ins_p.P352fs	NM_022304.2	NP_071640.1	P25021	HRH2_HUMAN	histamine receptor H2	352					G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(10)|ovary(1)	22	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	AGAAGTCACGGCCCCCCAGGGA	0.589													7	547	---	---	---	---					
KIAA1191	57179	broad.mit.edu	37	5	175774701	175774702	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:175774701_175774702insG	ENST00000298569.4	-	9	1352_1353	c.819_820insC	c.(817-822)ccagatfs	p.D274fs	KIAA1191_ENST00000393725.2_Frame_Shift_Ins_p.D255fs|KIAA1191_ENST00000393728.2_5'UTR|KIAA1191_ENST00000510164.1_Frame_Shift_Ins_p.D274fs	NM_020444.3	NP_065177.2	Q96A73	K1191_HUMAN	KIAA1191	274							protein binding			endometrium(1)|kidney(1)|lung(2)|ovary(1)|skin(1)	6	all_cancers(89;0.00575)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.101)		ATGTCCATCTTGGGGGGCTTCA	0.579													10	453	---	---	---	---					
ADAMTS2	9509	broad.mit.edu	37	5	178541085	178541086	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:178541085_178541086insG	ENST00000251582.7	-	22	3519_3520	c.3418_3419insC	c.(3418-3420)ggafs	p.G1140fs		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	1140					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		AGGGACCTCCAGGGGGGTGCTT	0.569													8	445	---	---	---	---					
EXOC2	55770	broad.mit.edu	37	6	637793	637794	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:637793_637794insG	ENST00000230449.4	-	2	160_161	c.25_26insC	c.(25-27)tgtfs	p.C9fs	EXOC2_ENST00000448181.3_Intron	NM_018303.4	NP_060773.3	Q96KP1	EXOC2_HUMAN	exocyst complex component 2	9	IPT/TIG.				exocytosis|protein transport			p.Q6fs*28(1)		breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|liver(1)|lung(16)|ovary(4)|pancreas(1)|prostate(2)	46	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		GCCGGTCACAAGGGGGGGTTGT	0.485													7	298	---	---	---	---					
GCNT2	2651	broad.mit.edu	37	6	10557409	10557410	+	Frame_Shift_Ins	INS	-	-	C	rs55808116		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:10557409_10557410insC	ENST00000316170.3	+	1	1170_1171	c.753_754insC	c.(751-756)ccccccfs	p.PP251fs	GCNT2_ENST00000379597.3_Intron|GCNT2_ENST00000397423.2_Intron|GCNT2_ENST00000410107.1_Intron|GCNT2_ENST00000495262.1_Intron	NM_001491.2	NP_001482.1	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	253						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		TGAAACCGCCTCCCCCCCATAA	0.485													17	340	---	---	---	---					
DCDC2	51473	broad.mit.edu	37	6	24205282	24205283	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:24205282_24205283insC	ENST00000378454.3	-	8	1271_1272	c.970_971insG	c.(970-972)agcfs	p.S324fs	DCDC2_ENST00000378450.3_Frame_Shift_Ins_p.S77fs	NM_001195610.1|NM_016356.3	NP_001182539.1|NP_057440.2	Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	324					cellular defense response|intracellular signal transduction|neuron migration					breast(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32		Ovarian(999;0.101)				GACTTCTGCTGCCCCCCGTGTT	0.411													13	1317	---	---	---	---					
MOG	4340	broad.mit.edu	37	6	29627216	29627217	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:29627216_29627217insC	ENST00000376894.4	+	2	327_328	c.209_210insC	c.(208-210)cccfs	p.P70fs	MOG_ENST00000396704.3_Frame_Shift_Ins_p.P70fs|MOG_ENST00000483013.1_Intron|MOG_ENST00000376902.3_Frame_Shift_Ins_p.P70fs|MOG_ENST00000376891.4_Frame_Shift_Ins_p.P70fs|MOG_ENST00000376917.3_Frame_Shift_Ins_p.P70fs|MOG_ENST00000469603.1_3'UTR|MOG_ENST00000416766.2_Frame_Shift_Ins_p.P70fs|MOG_ENST00000376888.2_Intron|MOG_ENST00000376898.3_Frame_Shift_Ins_p.P70fs|MOG_ENST00000431798.2_Frame_Shift_Ins_p.P70fs|MOG_ENST00000396701.2_Frame_Shift_Ins_p.P70fs|MOG_ENST00000533330.2_Frame_Shift_Ins_p.P70fs|MOG_ENST00000494692.1_Frame_Shift_Ins_p.P70fs|MOG_ENST00000490427.1_Intron			Q16653	MOG_HUMAN	myelin oligodendrocyte glycoprotein	70	Ig-like V-type.				cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane		p.F73fs*29(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|skin(2)	19						GGGTGGTACCGCCCCCCCTTCT	0.569													18	269	---	---	---	---					
BAG6	7917	broad.mit.edu	37	6	31608570	31608571	+	Splice_Site	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:31608570_31608571insG	ENST00000404765.2	-	21	3221_3222	c.2934_splice	c.e21+1	p.A978_splice	BAG6_ENST00000439687.2_Splice_Site_p.A816_splice|BAG6_ENST00000375976.4_Splice_Site_p.A942_splice|BAG6_ENST00000211379.5_Splice_Site_p.A942_splice|BAG6_ENST00000362049.6_Splice_Site_p.A942_splice|BAG6_ENST00000375964.6_Splice_Site_p.A948_splice			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	948					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						GTCCCTTACCTGGGGGGGATCA	0.535													8	207	---	---	---	---					
C6orf25	80739	broad.mit.edu	37	6	31692528	31692529	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:31692528_31692529insC	ENST00000375809.3	+	5	558_559	c.547_548insC	c.(547-549)cccfs	p.P183fs	C6orf25_ENST00000480039.1_Intron|C6orf25_ENST00000375810.4_Frame_Shift_Ins_p.P183fs|C6orf25_ENST00000375805.2_Frame_Shift_Ins_p.CP152fs	NM_025260.3|NM_138272.2|NM_138277.2	NP_079536.2|NP_612116.1|NP_612121.1	O95866	G6B_HUMAN	chromosome 6 open reading frame 25	0						endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	heparin binding|receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	9						TTCAGCTCTGTCCCCCCCACAT	0.579													14	374	---	---	---	---					
MAPK14	1432	broad.mit.edu	37	6	36068005	36068006	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:36068005_36068006insC	ENST00000229795.3	+	9	1170_1171	c.723_724insC	c.(721-726)acccccfs	p.TP241fs	MAPK14_ENST00000229794.4_Intron|MAPK14_ENST00000310795.4_Intron|MAPK14_ENST00000468133.1_Intron	NM_001315.2	NP_001306.1	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14	241	Protein kinase.				activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|stomach(1)	16						TGACAGGAACACCCCCCGCTTA	0.426													9	362	---	---	---	---					
KIAA0408	9729	broad.mit.edu	37	6	127767595	127767596	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:127767595_127767596insC	ENST00000483725.3	-	5	2204_2205	c.1868_1869insG	c.(1867-1869)gcafs	p.A623fs	SOGA3_ENST00000556132.1_3'UTR|SOGA3_ENST00000481848.2_3'UTR	NM_014702.4	NP_055517.3	Q6ZU52	K0408_HUMAN	KIAA0408	623							protein binding			endometrium(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|skin(1)	28				GBM - Glioblastoma multiforme(226;0.0217)|all cancers(137;0.13)		TCACTTCCTGTCCCCCCCACAC	0.401													7	421	---	---	---	---					
ARHGAP18	93663	broad.mit.edu	37	6	129959602	129959603	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:129959602_129959603insT	ENST00000368149.2	-	3	576_577	c.488_489insA	c.(487-489)aaafs	p.K163fs		NM_033515.2	NP_277050.2	Q8N392	RHG18_HUMAN	Rho GTPase activating protein 18	163					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(2)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(3)	18				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		GGTACTGTTTGTTTTTTTTCCT	0.421													7	367	---	---	---	---					
IPCEF1	26034	broad.mit.edu	37	6	154481012	154481013	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:154481012_154481013insG	ENST00000265198.4	-	12	1419_1420	c.1264_1265insC	c.(1264-1266)ggafs	p.G422fs	OPRM1_ENST00000337049.4_Intron|IPCEF1_ENST00000367220.4_Frame_Shift_Ins_p.G423fs|IPCEF1_ENST00000422970.2_Frame_Shift_Ins_p.G423fs|IPCEF1_ENST00000519344.1_Frame_Shift_Ins_p.G394fs	NM_001130700.1|NM_015553.2	NP_001124172.1|NP_056368.1			interaction protein for cytohesin exchange factors 1											breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	12						CTTGAGTTCCTGGGGGGTGTCA	0.460													8	256	---	---	---	---					
EIF3B	8662	broad.mit.edu	37	7	2404085	2404086	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr7:2404085_2404086insG	ENST00000360876.4	+	6	1134_1135	c.1078_1079insG	c.(1078-1080)gggfs	p.G360fs	EIF3B_ENST00000397011.2_Frame_Shift_Ins_p.G360fs	NM_001037283.1	NP_001032360.1	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3, subunit B	360	Sufficient for interaction with EIF3E.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	24		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CATTGCTCTATGGGGGGGAGAG	0.475													7	213	---	---	---	---					
PMS2CL	441194	broad.mit.edu	37	7	6759412	6759413	+	RNA	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr7:6759412_6759413insG	ENST00000486256.1	+	0	346					NR_002217.1																						GTGTGCCTCCCGGGGGGGAGGT	0.569													9	177	---	---	---	---					
NUPL2	11097	broad.mit.edu	37	7	23224772	23224773	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr7:23224772_23224773insG	ENST00000258742.5	+	2	464_465	c.205_206insG	c.(205-207)gggfs	p.G69fs	AC005082.1_ENST00000366347.4_Intron|NUPL2_ENST00000487595.1_3'UTR|NUPL2_ENST00000410002.3_Frame_Shift_Ins_p.G69fs	NM_007342.2	NP_031368.1	O15504	NUPL2_HUMAN	nucleoporin like 2	69					carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ATCCACACCATGGGGGGGCAGC	0.406													18	213	---	---	---	---					
GRM3	2913	broad.mit.edu	37	7	86415681	86415682	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr7:86415681_86415682insC	ENST00000361669.2	+	3	1672_1673	c.573_574insC	c.(571-576)gtccccfs	p.VP191fs	AC005009.2_ENST00000418031.1_RNA|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000536043.1_Frame_Shift_Ins_p.VP63fs|AC005009.2_ENST00000452471.1_RNA|GRM3_ENST00000394720.2_Frame_Shift_Ins_p.VP189fs|GRM3_ENST00000439827.1_Frame_Shift_Ins_p.VP191fs	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	191					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	CCAGGACCGTGCCCCCCGACTT	0.564													8	419	---	---	---	---					
SAMD9L	219285	broad.mit.edu	37	7	92761061	92761061	+	Frame_Shift_Del	DEL	T	T	-			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr7:92761061delT	ENST00000318238.4	-	5	5440	c.4224delA	c.(4222-4224)aafs	p.K1408fs	SAMD9L_ENST00000411955.1_Frame_Shift_Del_p.K1408fs|SAMD9L_ENST00000437805.1_Frame_Shift_Del_p.K1408fs	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1408										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CTCGGAGTTGTTTTTTTAGCG	0.408													9	1526	---	---	---	---					
SRRT	51593	broad.mit.edu	37	7	100479331	100479332	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr7:100479331_100479332insG	ENST00000388793.4	+	4	523_524	c.303_304insG	c.(301-306)gcggggfs	p.AG101fs	SRRT_ENST00000432932.1_Frame_Shift_Ins_p.AG101fs|SRRT_ENST00000347433.4_Frame_Shift_Ins_p.AG101fs|SRRT_ENST00000457580.2_Frame_Shift_Ins_p.AG101fs	NM_001128852.1|NM_015908.5	NP_001122324.1|NP_056992.4	Q9BXP5	SRRT_HUMAN	serrate RNA effector molecule homolog (Arabidopsis)	101					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding	p.G104fs*45(1)		breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						TGCCCTATGCTGGGGGGGGTGG	0.609													14	216	---	---	---	---					
CCDC136	64753	broad.mit.edu	37	7	128457829	128457830	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr7:128457829_128457830insC	ENST00000297788.4	+	17	3748_3749	c.3381_3382insC	c.(3379-3384)aaccccfs	p.NP1127fs	CCDC136_ENST00000487361.1_Frame_Shift_Ins_p.NP488fs|CCDC136_ENST00000464832.1_Frame_Shift_Ins_p.NP419fs|CCDC136_ENST00000378685.4_Frame_Shift_Ins_p.NP407fs|CCDC136_ENST00000471729.1_Intron	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	1127						integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						CTACCCCCAATCCCCCCATCTT	0.520													11	1806	---	---	---	---					
C7orf55-LUC7L2	100996928	broad.mit.edu	37	7	139092039	139092040	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr7:139092039_139092040insG	ENST00000354926.4	+	6	984_985	c.630_631insG	c.(628-633)ttggggfs	p.LG210fs	LUC7L2_ENST00000541515.3_Frame_Shift_Ins_p.LG276fs|C7orf55-LUC7L2_ENST00000263545.6_Frame_Shift_Ins_p.LG209fs|C7orf55-LUC7L2_ENST00000541170.3_Frame_Shift_Ins_p.LG207fs	NM_016019.3	NP_057103.2																					CTGATCATTTTGGGGGTAAACT	0.401													7	240	---	---	---	---					
TRBV4-2	28616	broad.mit.edu	37	7	142045511	142045512	+	RNA	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr7:142045511_142045512insC	ENST00000390392.3	+	0	160																											TTTGTCCCTTTCCCCCCGCAGT	0.485													8	706	---	---	---	---					
PRSS3P2	154754	broad.mit.edu	37	7	142482025	142482025	+	RNA	DEL	A	A	-			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr7:142482025delA	ENST00000603901.1	+	0	591					NR_001296.3																						TGCAGTGCCCACATGGAGAAG	0.572													6	10	---	---	---	---					
INTS9	55756	broad.mit.edu	37	8	28633353	28633354	+	Frame_Shift_Ins	INS	-	-	G	rs148560235		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr8:28633353_28633354insG	ENST00000416984.2	-	13	1781_1782	c.1422_1423insC	c.(1420-1425)ccccatfs	p.H475fs	INTS9_ENST00000397363.4_Frame_Shift_Ins_p.H390fs|INTS9_ENST00000521777.1_Frame_Shift_Ins_p.H472fs|INTS9_ENST00000521022.1_Frame_Shift_Ins_p.H496fs	NM_001145159.2	NP_001138631.1	Q9NV88	INT9_HUMAN	integrator complex subunit 9	496					snRNA processing	integrator complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(2)	19		Ovarian(32;0.0439)		KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.152)		TAGGACATGGCGGGGGGCTGGC	0.619													8	127	---	---	---	---					
TEK	7010	broad.mit.edu	37	9	27204925	27204926	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr9:27204925_27204926insG	ENST00000380036.4	+	14	2668_2669	c.2226_2227insG	c.(2224-2229)ggggggfs	p.GG742fs	TEK_ENST00000406359.4_Frame_Shift_Ins_p.GG699fs|TEK_ENST00000519097.1_Frame_Shift_Ins_p.GG595fs	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	742					angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		CGGACCTCGGAGGGGGGAAGAT	0.510													7	288	---	---	---	---					
PIGO	84720	broad.mit.edu	37	9	35091522	35091523	+	Frame_Shift_Ins	INS	-	-	G	rs144233446		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr9:35091522_35091523insG	ENST00000378617.3	-	7	2755_2756	c.2361_2362insC	c.(2359-2364)cccttcfs	p.F788fs	PIGO_ENST00000298004.5_Intron|PIGO_ENST00000341666.3_Frame_Shift_Ins_p.F788fs|PIGO_ENST00000361778.2_Intron	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	788					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity	p.T788fs*5(1)		endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GCTTGAGAAGTGGGGGGGCCTG	0.604													10	206	---	---	---	---					
AKNA	80709	broad.mit.edu	37	9	117108194	117108194	+	Frame_Shift_Del	DEL	C	C	-			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr9:117108194delC	ENST00000307564.4	-	18	3771	c.3610delG	c.(3610-3612)tgfs	p.V1204fs	AKNA_ENST00000374088.3_Frame_Shift_Del_p.V1204fs|AKNA_ENST00000492875.1_5'UTR|AKNA_ENST00000223791.3_Frame_Shift_Del_p.V664fs|AKNA_ENST00000374075.5_Frame_Shift_Del_p.V1123fs|AKNA_ENST00000374079.4_Frame_Shift_Del_p.V149fs	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	1204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						GCACTGCCCACCCCTCTCTTT	0.617													18	96	---	---	---	---					
TAF3	83860	broad.mit.edu	37	10	8006928	8006929	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:8006928_8006929insC	ENST00000344293.5	+	3	1661_1662	c.1455_1456insC	c.(1453-1458)atccccfs	p.IP485fs		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	485					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						CTTCAAATATGCCCCCCAACTT	0.490													7	479	---	---	---	---					
PHYH	5264	broad.mit.edu	37	10	13325834	13325835	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:13325834_13325835insC	ENST00000396920.3	-	7	1036_1037	c.632_633insG	c.(631-633)ggtfs	p.G211fs	PHYH_ENST00000263038.4_Frame_Shift_Ins_p.G228fs|PHYH_ENST00000396913.2_Frame_Shift_Ins_p.G128fs			O14832	PAHX_HUMAN	phytanoyl-CoA 2-hydroxylase	228					fatty acid alpha-oxidation|nervous system development	peroxisomal matrix	electron carrier activity|L-ascorbic acid binding|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|phytanoyl-CoA dioxygenase activity|protein binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)	25		Ovarian(717;0.0448)			Antihemophilic Factor(DB00025)|Vitamin C(DB00126)	TTTTGTTAACTCCCCCCTAGAA	0.465													15	846	---	---	---	---					
CUBN	8029	broad.mit.edu	37	10	16877089	16877090	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:16877089_16877090insG	ENST00000377833.4	-	64	10350_10351	c.10285_10286insC	c.(10285-10287)gaafs	p.E3429fs		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	3429	CUB 26.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGTGTGGTTCTGGGGGGCTGTG	0.450													7	697	---	---	---	---					
MLLT10	8028	broad.mit.edu	37	10	21962451	21962452	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:21962451_21962452insG	ENST00000377072.3	+	11	1572_1573	c.1224_1225insG	c.(1222-1227)gaggggfs	p.EG408fs	MLLT10_ENST00000307729.7_Frame_Shift_Ins_p.EG408fs|MLLT10_ENST00000377059.3_Frame_Shift_Ins_p.EG408fs|MLLT10_ENST00000446906.2_Frame_Shift_Ins_p.EG408fs	NM_004641.3	NP_004632.1	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	408	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.V411fs*3(1)		NS(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6						GAAGCCAGGAAGGGGGGGTAAA	0.436			T	"""MLL, PICALM, CDK6"""	AL								21	735	---	---	---	---					
KIAA1217	56243	broad.mit.edu	37	10	24832466	24832467	+	Frame_Shift_Ins	INS	-	-	C	rs61734877		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:24832466_24832467insC	ENST00000376451.2	+	14	3576_3577	c.3316_3317insC	c.(3316-3318)cccfs	p.P1106fs	KIAA1217_ENST00000307544.6_Intron|KIAA1217_ENST00000376462.1_Intron|KIAA1217_ENST00000396445.1_Intron|KIAA1217_ENST00000458595.1_Intron|KIAA1217_ENST00000396446.1_Intron|KIAA1217_ENST00000376454.3_Frame_Shift_Ins_p.P1423fs|KIAA1217_ENST00000376452.3_Intron			Q5T5P2	SKT_HUMAN	KIAA1217	1423					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						AAAAGAGATGACCCCCCGACAA	0.495													9	517	---	---	---	---					
MKX	283078	broad.mit.edu	37	10	28023574	28023575	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:28023574_28023575insG	ENST00000375790.5	-	5	1080_1081	c.648_649insC	c.(646-651)ccaatafs	p.I217fs	MKX_ENST00000419761.1_Frame_Shift_Ins_p.I217fs			Q8IYA7	MKX_HUMAN	mohawk homeobox	217					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.P216P(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16						CTCTTGTATTTGGGGGGTGCCA	0.485													7	393	---	---	---	---					
ZEB1	6935	broad.mit.edu	37	10	31809832	31809833	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:31809832_31809833insG	ENST00000446923.2	+	7	1912_1913	c.1521_1522insG	c.(1519-1524)gaggggfs	p.EG507fs	ZEB1_ENST00000560721.2_Frame_Shift_Ins_p.EG503fs|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000361642.5_Frame_Shift_Ins_p.EG524fs|ZEB1_ENST00000542815.3_Frame_Shift_Ins_p.EG456fs|ZEB1_ENST00000320985.10_Frame_Shift_Ins_p.EG523fs	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	523					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				AAAGCTTTGAAGGGGGGGTGAA	0.371													12	384	---	---	---	---					
ZNF248	57209	broad.mit.edu	37	10	38121236	38121237	+	Frame_Shift_Ins	INS	-	-	C	rs34731183		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:38121236_38121237insC	ENST00000395867.3	-	6	1596_1597	c.1046_1047insG	c.(1045-1047)gaafs	p.E349fs	ZNF248_ENST00000357328.4_Frame_Shift_Ins_p.E349fs|ZNF248_ENST00000494133.1_Intron|ZNF248_ENST00000374648.3_Intron	NM_001267605.1|NM_001267606.1|NM_001267607.1|NM_021045.2	NP_001254534.1|NP_001254535.1|NP_001254536.1|NP_066383.1	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(2)|urinary_tract(1)	20						CATAAGACTTTCCCCCCATGTG	0.401													12	702	---	---	---	---					
BMS1	9790	broad.mit.edu	37	10	43294047	43294048	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:43294047_43294048insC	ENST00000374518.4	+	12	2284_2285	c.2221_2222insC	c.(2221-2223)cccfs	p.P741fs		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	741					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TCTTGTGGAGGCCCCCCATGAC	0.431													7	821	---	---	---	---					
C10orf71	118461	broad.mit.edu	37	10	50530937	50530938	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:50530937_50530938insC	ENST00000374144.3	+	3	635_636	c.347_348insC	c.(346-348)accfs	p.T116fs	C10orf71_ENST00000323868.4_Frame_Shift_Ins_p.T116fs			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	116										endometrium(1)	1						CCCAAAACCAGCCCCCCACCAA	0.545													7	691	---	---	---	---					
CHAT	1103	broad.mit.edu	37	10	50857606	50857607	+	Frame_Shift_Ins	INS	-	-	C	rs3793795		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:50857606_50857607insC	ENST00000395562.2	+	11	1658_1659	c.1189_1190insC	c.(1189-1191)cccfs	p.P397fs	CHAT_ENST00000339797.1_Frame_Shift_Ins_p.P361fs|CHAT_ENST00000337653.2_Frame_Shift_Ins_p.P479fs|CHAT_ENST00000351556.3_Frame_Shift_Ins_p.P361fs|CHAT_ENST00000455728.2_Frame_Shift_Ins_p.P361fs|CHAT_ENST00000395559.2_Frame_Shift_Ins_p.P361fs	NM_001142933.1|NM_001142934.1	NP_001136405.1|NP_001136406.1	P28329	CLAT_HUMAN	choline O-acetyltransferase	479					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(11)|lung(34)|prostate(3)|urinary_tract(1)	56		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	CGAGCTCCCCGCCCCCCGGAGG	0.609													7	142	---	---	---	---					
FAM21EP	100421577	broad.mit.edu	37	10	51821327	51821328	+	RNA	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:51821327_51821328insG	ENST00000456967.1	-	0	1306_1307					NR_038275.1																						TCGGTCAGCTTGGGGGGTGCGA	0.520													8	534	---	---	---	---					
CSTF2T	23283	broad.mit.edu	37	10	53458899	53458900	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:53458899_53458900insG	ENST00000331173.4	-	1	455_456	c.410_411insC	c.(409-411)cgafs	p.R137fs	PRKG1_ENST00000401604.2_Intron|PRKG1_ENST00000373980.4_Intron|PRKG1_ENST00000373985.1_Intron	NM_015235.2	NP_056050.1	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant	137					mRNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		ACATCTGCTCCGGGGGGAGACT	0.515													7	258	---	---	---	---					
PALD1	27143	broad.mit.edu	37	10	72292440	72292441	+	Frame_Shift_Ins	INS	-	-	G	rs145337663	byFrequency	TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:72292440_72292441insG	ENST00000263563.6	+	6	965_966	c.697_698insG	c.(697-699)gggfs	p.G233fs		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		CGAGGACCTGTGGGGGGAGCCC	0.604													11	1080	---	---	---	---					
SEC24C	9632	broad.mit.edu	37	10	75525559	75525560	+	Splice_Site	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:75525559_75525560insC	ENST00000339365.2	+	11	1530_1531	c.1366_splice	c.e11-1	p.VP456_splice	SEC24C_ENST00000411652.2_Splice_Site_p.VP337_splice|SEC24C_ENST00000345254.4_Splice_Site_p.VP456_splice|SEC24C_ENST00000546025.1_Intron|SEC24C_ENST00000535742.1_Intron|SEC24C_ENST00000540668.1_Intron	NM_004922.3	NP_004913.2	P53992	SC24C_HUMAN	SEC24 family member C	456					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(12)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Prostate(51;0.0112)					TTCCCACAGTTCCCCCCCAGTA	0.510													36	781	---	---	---	---					
CDHR1	92211	broad.mit.edu	37	10	85972096	85972097	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:85972096_85972097insC	ENST00000372117.3	+	15	1818_1819	c.1715_1716insC	c.(1714-1716)cccfs	p.P572fs	CDHR1_ENST00000332904.3_Frame_Shift_Ins_p.P572fs|CDHR1_ENST00000440770.2_Frame_Shift_Ins_p.P276fs	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	572	Cadherin 5.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						GTCAATGACCACCCCCCTCAGT	0.510													11	701	---	---	---	---					
HECTD2	143279	broad.mit.edu	37	10	93272060	93272061	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:93272060_93272061insC	ENST00000446394.1	+	22	2362_2363	c.2262_2263insC	c.(2260-2265)ctccccfs	p.LP754fs	HECTD2_ENST00000371667.1_Frame_Shift_Ins_p.LP400fs|HECTD2_ENST00000298068.5_Frame_Shift_Ins_p.LP750fs|HECTD2_ENST00000536715.1_Frame_Shift_Ins_p.LP339fs			Q5U5R9	HECD2_HUMAN	HECT domain containing E3 ubiquitin protein ligase 2	750	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(10)|lung(7)|skin(1)|urinary_tract(1)	27						AACTTTGCCTTCCCCCCTACAA	0.356													11	870	---	---	---	---					
DNTT	1791	broad.mit.edu	37	10	98079053	98079054	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:98079053_98079054insC	ENST00000419175.1	+	3	583_584	c.413_414insC	c.(412-414)gccfs	p.A138fs	DNTT_ENST00000371174.2_Frame_Shift_Ins_p.A138fs	NM_001017520.1|NM_004088.3	NP_001017520.1|NP_004079.3	P04053	TDT_HUMAN	DNA nucleotidylexotransferase	138					DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		ACCAACCCAGGCCCCCCGAAGA	0.396													7	316	---	---	---	---					
CUTC	51076	broad.mit.edu	37	10	101499503	101499504	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:101499503_101499504insG	ENST00000370476.5	+	3	299_300	c.170_171insG	c.(169-171)gggfs	p.G57fs	CUTC_ENST00000493385.1_3'UTR	NM_015960.2	NP_057044.2	Q9NTM9	CUTC_HUMAN	cutC copper transporter	57					copper ion homeostasis|copper ion transport|protein tetramerization	cytoplasm|nucleus	copper ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14		Colorectal(252;0.234)		Epithelial(162;3e-10)|all cancers(201;2.37e-08)		GGTTTATCAGAGGGGGGAACTA	0.401													8	632	---	---	---	---					
PAX2	5076	broad.mit.edu	37	10	102509528	102509529	+	Frame_Shift_Ins	INS	-	-	G	rs75462234		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:102509528_102509529insG	ENST00000370296.2	+	2	619_620	c.69_70insG	c.(67-72)ctggggfs	p.LG23fs	PAX2_ENST00000428433.1_Frame_Shift_Ins_p.LG23fs|PAX2_ENST00000553492.1_Intron|PAX2_ENST00000355243.3_Frame_Shift_Ins_p.LG23fs|PAX2_ENST00000556085.1_Frame_Shift_Ins_p.LG22fs|PAX2_ENST00000361791.3_Frame_Shift_Ins_p.LG23fs			Q02962	PAX2_HUMAN	paired box 2	23	Paired.				anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	18		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		TGAACCAGCTCGGGGGGGTGTT	0.663													11	91	---	---	---	---					
PSD	5662	broad.mit.edu	37	10	104164414	104164415	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:104164414_104164415insG	ENST00000020673.5	-	15	3151_3152	c.2625_2626insC	c.(2623-2628)cctcccfs	p.P876fs	PSD_ENST00000406432.1_Frame_Shift_Ins_p.P876fs	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	876					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		GCAGCTGGGAAGGGGGGCGCAG	0.609													11	844	---	---	---	---					
TRUB1	142940	broad.mit.edu	37	10	116730191	116730192	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:116730191_116730192insC	ENST00000298746.3	+	5	649_650	c.588_589insC	c.(586-591)gtccccfs	p.VP196fs		NM_139169.4	NP_631908.1	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase family member 1	196					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(2)|kidney(2)|large_intestine(1)|lung(5)|urinary_tract(2)	12		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		TAATGCAAGTGCCCCCCCTGTA	0.317													15	329	---	---	---	---					
SLC18A2	6571	broad.mit.edu	37	10	119014791	119014792	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:119014791_119014792insC	ENST00000298472.5	+	7	847_848	c.704_705insC	c.(703-705)gccfs	p.A235fs	SLC18A2_ENST00000497497.1_3'UTR	NM_003054.4	NP_003045.2	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 2	235					neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)	29		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	CCTGCAGTGGGCCCCCCCTTCG	0.569													9	173	---	---	---	---					
IKZF5	64376	broad.mit.edu	37	10	124754014	124754015	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:124754014_124754015insC	ENST00000368886.5	-	5	861_862	c.541_542insG	c.(541-543)tttfs	p.F181fs	PSTK_ENST00000497219.1_Intron	NM_001271840.1	NP_001258769.1	Q9H5V7	IKZF5_HUMAN	IKAROS family zinc finger 5 (Pegasus)	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|lung(3)|prostate(1)	6		all_neural(114;0.169)|Colorectal(57;0.178)|Glioma(114;0.222)		Colorectal(40;0.0701)|COAD - Colon adenocarcinoma(40;0.0754)		CTTCTGTAAAACCCCCCACATT	0.426													10	481	---	---	---	---					
LINC00959	387723	broad.mit.edu	37	10	131905959	131905960	+	RNA	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr10:131905959_131905960insG	ENST00000456581.1	-	0	114																											CTTTGCCTCCAGGGGGGGAAGG	0.530													11	297	---	---	---	---					
DCHS1	8642	broad.mit.edu	37	11	6655045	6655046	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:6655045_6655046insG	ENST00000299441.3	-	4	2603_2604	c.2192_2193insC	c.(2191-2193)cctfs	p.P731fs	RP11-732A19.6_ENST00000526633.1_RNA	NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	731	Cadherin 7.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGTAAAAAGTGGGGGGCTGTT	0.604													7	564	---	---	---	---					
EIF4G2	1982	broad.mit.edu	37	11	10820934	10820935	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:10820934_10820935insG	ENST00000526148.1	-	20	2871_2872	c.2361_2362insC	c.(2359-2364)ccgcgafs	p.R788fs	EIF4G2_ENST00000396525.2_Frame_Shift_Ins_p.R750fs|RP11-685M7.5_ENST00000532365.1_RNA|EIF4G2_ENST00000525681.1_Frame_Shift_Ins_p.R788fs|EIF4G2_ENST00000339995.5_Frame_Shift_Ins_p.R788fs	NM_001172705.1	NP_001166176.1	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4 gamma, 2	788	W2.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity	p.S788R(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	43				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		GTTTCATCGCTGGGGGGGTTTA	0.406													9	177	---	---	---	---					
APIP	51074	broad.mit.edu	37	11	34904908	34904909	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:34904908_34904909insC	ENST00000395787.3	-	6	818_819	c.604_605insG	c.(604-606)aacfs	p.N202fs	APIP_ENST00000278359.5_Frame_Shift_Ins_p.N219fs|APIP_ENST00000527830.1_5'UTR	NM_015957.2	NP_057041.2	Q96GX9	MTNB_HUMAN	APAF1 interacting protein	202					apoptosis|L-methionine salvage	cytoplasm	identical protein binding|metal ion binding|methylthioribulose 1-phosphate dehydratase activity			kidney(2)|lung(1)|skin(1)	4	all_epithelial(35;0.161)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.000425)			CTCCCATGTTTCCCCCCACACA	0.450													11	729	---	---	---	---					
NR1H3	10062	broad.mit.edu	37	11	47282886	47282887	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:47282886_47282887insC	ENST00000467728.1	+	4	1832_1833	c.594_595insC	c.(592-597)tcccccfs	p.SP198fs	NR1H3_ENST00000405853.3_Frame_Shift_Ins_p.SP198fs|NR1H3_ENST00000407404.1_Frame_Shift_Ins_p.SP198fs|NR1H3_ENST00000529540.1_3'UTR|NR1H3_ENST00000395397.3_Frame_Shift_Ins_p.SP153fs|NR1H3_ENST00000481889.2_Frame_Shift_Ins_p.SP153fs|NR1H3_ENST00000441012.2_Frame_Shift_Ins_p.SP198fs|NR1H3_ENST00000405576.1_Frame_Shift_Ins_p.SP153fs|NR1H3_ENST00000527949.1_Frame_Shift_Ins_p.SP107fs			Q13133	NR1H3_HUMAN	nuclear receptor subfamily 1, group H, member 3	198					apoptotic cell clearance|cellular response to lipopolysaccharide|cholesterol homeostasis|negative regulation of cholesterol storage|negative regulation of inflammatory response|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of macrophage activation|negative regulation of pancreatic juice secretion|negative regulation of pinocytosis|negative regulation of secretion of lysosomal enzymes|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor biosynthetic process|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of circadian rhythm|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to progesterone stimulus|triglyceride homeostasis	nuclear chromatin|nucleoplasm	cholesterol binding|steroid hormone receptor activity|sterol response element binding|transcription coactivator activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|ovary(5)	20						GGGCTTCCTCACCCCCCCAAAT	0.594													8	78	---	---	---	---					
OR4S1	256148	broad.mit.edu	37	11	48328524	48328525	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:48328524_48328525insC	ENST00000319988.1	+	1	750_751	c.750_751insC	c.(748-753)atccccfs	p.IP250fs		NM_001004725.1	NP_001004725.1	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S, member 1	250					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|skin(3)	21						TGGTTCTCATGCCCCCCATGTT	0.480													8	875	---	---	---	---					
OR5AR1	219493	broad.mit.edu	37	11	56431466	56431467	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:56431466_56431467insT	ENST00000302969.2	+	1	329_330	c.305_306insT	c.(304-306)gttfs	p.V102fs		NM_001004730.1	NP_001004730.1	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR, member 1 (gene/pseudogene)	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(12)|prostate(1)|skin(3)|stomach(1)	26						ACCCAGTTTGCTTTTTTTGTAG	0.510													8	738	---	---	---	---					
SLC43A3	29015	broad.mit.edu	37	11	57185234	57185235	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:57185234_57185235insG	ENST00000395123.2	-	8	961_962	c.657_658insC	c.(655-660)ccactafs	p.L220fs	SLC43A3_ENST00000533524.1_Frame_Shift_Ins_p.L233fs|SLC43A3_ENST00000529554.1_Frame_Shift_Ins_p.L220fs|SLC43A3_ENST00000528098.1_5'UTR|SLC43A3_ENST00000352187.1_Frame_Shift_Ins_p.L220fs|SLC43A3_ENST00000395124.1_Frame_Shift_Ins_p.L220fs	NM_001278201.1|NM_014096.2	NP_001265130.1|NP_054815.2	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	220					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(10)|lung(4)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	27						TAGCTGTAGTTGGGGGGCAGTG	0.564													10	314	---	---	---	---					
DDB1	1642	broad.mit.edu	37	11	61094367	61094368	+	Splice_Site	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:61094367_61094368insG	ENST00000301764.7	-	5	947		c.e5-2		DDB1_ENST00000450997.2_Intron|DDB1_ENST00000545930.1_Splice_Site	NM_001923.4	NP_001914.3	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1, 127kDa						cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	48						CTGAGGGTCCTGGGGGGGAAAG	0.515								Nucleotide excision repair (NER)					7	355	---	---	---	---					
BSCL2	26580	broad.mit.edu	37	11	62458782	62458783	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:62458782_62458783insC	ENST00000433053.1	-	8	1530_1531	c.974_975insG	c.(973-975)gatfs	p.D325fs	BSCL2_ENST00000421906.1_Frame_Shift_Ins_p.D261fs|BSCL2_ENST00000407022.3_Frame_Shift_Ins_p.D261fs|RP11-831H9.16_ENST00000403734.2_3'UTR|BSCL2_ENST00000405837.1_Frame_Shift_Ins_p.D325fs|BSCL2_ENST00000403550.1_Frame_Shift_Ins_p.D261fs|BSCL2_ENST00000278893.7_Intron|BSCL2_ENST00000360796.5_Frame_Shift_Ins_p.D325fs			Q96G97	BSCL2_HUMAN	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	261					cell death	integral to endoplasmic reticulum membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	12						GGGGCCAGATGCCCCCCCACAC	0.559													13	217	---	---	---	---					
DPP3	10072	broad.mit.edu	37	11	66272154	66272155	+	Frame_Shift_Ins	INS	-	-	C	rs142447712		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:66272154_66272155insC	ENST00000532677.1	+	17	2408_2409	c.2007_2008insC	c.(2005-2010)gcccccfs	p.AP669fs	DPP3_ENST00000453114.1_Frame_Shift_Ins_p.AP650fs|DPP3_ENST00000360510.2_Frame_Shift_Ins_p.AP650fs|DPP3_ENST00000530165.1_Frame_Shift_Ins_p.AP620fs|DPP3_ENST00000541961.1_Frame_Shift_Ins_p.AP650fs|DPP3_ENST00000531863.1_Frame_Shift_Ins_p.AP670fs	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	650					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						TCACTGATGCGCCCCCCGAGTG	0.579													9	222	---	---	---	---					
ALDH3B2	222	broad.mit.edu	37	11	67433066	67433067	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:67433066_67433067insC	ENST00000349015.3	-	7	833_834	c.395_396insG	c.(394-396)gaafs	p.E132fs	ALDH3B2_ENST00000530069.1_Frame_Shift_Ins_p.E132fs	NM_000695.3	NP_000686.2	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	132				G -> V (in Ref. 4; BAC03897).	alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	AGGGGTTCTTGCCCCCCAGCTC	0.644													9	604	---	---	---	---					
ALDH3B1	221	broad.mit.edu	37	11	67789023	67789024	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:67789023_67789024insG	ENST00000539229.1	+	8	745_746	c.629_630insG	c.(628-630)cggfs	p.R210fs	ALDH3B1_ENST00000007633.8_Frame_Shift_Ins_p.R210fs|ALDH3B1_ENST00000434449.1_3'UTR|ALDH3B1_ENST00000316367.6_Intron|ALDH3B1_ENST00000342456.6_Frame_Shift_Ins_p.R174fs	NM_001161473.1	NP_001154945.1	P43353	AL3B1_HUMAN	aldehyde dehydrogenase 3 family, member B1	211					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase									NADH(DB00157)	ACCCTGGAGCTGGGGGGCAAGA	0.634											OREG0021141	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	449	---	---	---	---					
RDX	5962	broad.mit.edu	37	11	110104136	110104137	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:110104136_110104137insG	ENST00000343115.4	-	13	1731_1732	c.1412_1413insC	c.(1411-1413)cccfs	p.P471fs	RDX_ENST00000528900.1_Frame_Shift_Ins_p.P124fs|RDX_ENST00000528498.1_Frame_Shift_Ins_p.P471fs|RDX_ENST00000405097.1_Frame_Shift_Ins_p.P471fs|RDX_ENST00000544551.1_Frame_Shift_Ins_p.P335fs|RDX_ENST00000530301.1_Intron	NM_001260494.1|NM_002906.3	NP_001247423.1|NP_002897.1	P35241	RADI_HUMAN	radixin	471	Glu-rich.|Poly-Pro.				actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	18		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)		GTGGAGGTGGAGGGGGGGCAGA	0.431													17	480	---	---	---	---					
CLDN25	644672	broad.mit.edu	37	11	113650550	113650551	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:113650550_113650551insG	ENST00000453129.2	+	1	82_83	c.33_34insG	c.(31-36)ctggggfs	p.LG11fs		NM_001101389.1	NP_001094859.1	C9JDP6	CLD25_HUMAN	claudin 25	11						integral to membrane|tight junction	structural molecule activity	p.L14fs*24(1)		large_intestine(1)|lung(6)|ovary(1)|urinary_tract(2)	10						AAGTCCAGCTCGGGGGGCTACT	0.550													7	280	---	---	---	---					
IGSF9B	22997	broad.mit.edu	37	11	133807826	133807827	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:133807826_133807827insG	ENST00000321016.8	-	4	669_670	c.439_440insC	c.(439-441)gtafs	p.V147fs	IGSF9B_ENST00000533871.2_Frame_Shift_Ins_p.V147fs			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	147	Ig-like 2.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CTCGATGTACTGGGGGGGTGTT	0.574													7	166	---	---	---	---					
JAM3	83700	broad.mit.edu	37	11	134018467	134018468	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:134018467_134018468insG	ENST00000299106.4	+	7	897_898	c.738_739insG	c.(736-741)atggggfs	p.MG246fs	JAM3_ENST00000441717.3_Frame_Shift_Ins_p.MG195fs|JAM3_ENST00000529443.2_Frame_Shift_Ins_p.MG291fs			Q9BX67	JAM3_HUMAN	junctional adhesion molecule 3	246					angiogenesis|blood coagulation|regulation of neutrophil chemotaxis	cell-cell contact zone|desmosome|extracellular space|integral to membrane	integrin binding			breast(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)	10	all_hematologic(175;0.127)	all_cancers(12;1.06e-21)|all_epithelial(12;3.37e-16)|all_lung(97;7.03e-06)|Lung NSC(97;1.67e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0506)|Esophageal squamous(93;0.0566)		Epithelial(10;1.55e-09)|BRCA - Breast invasive adenocarcinoma(10;1.35e-08)|all cancers(11;2.81e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00402)|Lung(977;0.245)		GCGGAATTATTGGGGGGGTTCT	0.485													9	348	---	---	---	---					
NCAPD3	23310	broad.mit.edu	37	11	134048585	134048586	+	Frame_Shift_Ins	INS	-	-	G	rs138442478		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr11:134048585_134048586insG	ENST00000534548.2	-	22	2789_2790	c.2725_2726insC	c.(2725-2727)ggtfs	p.G909fs		NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	909					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding	p.Q909fs*12(1)		NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		ACCTCTGACCTGGGGGGGTGGC	0.525													18	313	---	---	---	---					
VWF	7450	broad.mit.edu	37	12	6153463	6153464	+	Frame_Shift_Ins	INS	-	-	G	rs137990643	by1000genomes	TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:6153463_6153464insG	ENST00000261405.5	-	18	2689_2690	c.2435_2436insC	c.(2434-2436)cggfs	p.R812fs		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	812	E1.|TIL 3.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	TCACCATGCCCGGGGGGCAGAG	0.594													8	284	---	---	---	---					
CD4	920	broad.mit.edu	37	12	6924042	6924043	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:6924042_6924043insG	ENST00000011653.4	+	5	749_750	c.491_492insG	c.(490-492)cggfs	p.R164fs	CD4_ENST00000541982.1_Frame_Shift_Ins_p.R109fs|CD4_ENST00000538827.1_3'UTR	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	164	Ig-like C2-type 1.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				AAAAACATACAGGGGGGGAAGA	0.564													10	442	---	---	---	---					
C1S	716	broad.mit.edu	37	12	7171652	7171653	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:7171652_7171653insC	ENST00000406697.1	+	8	1101_1102	c.473_474insC	c.(472-474)tccfs	p.S158fs	C1S_ENST00000328916.3_Frame_Shift_Ins_p.S158fs|C1S_ENST00000402681.3_5'UTR|C1S_ENST00000360817.5_Frame_Shift_Ins_p.S158fs			P09871	C1S_HUMAN	complement component 1, s subcomponent	158	EGF-like; calcium-binding.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	TTCTGCTCCTGCCCCCCGGAAT	0.455													8	467	---	---	---	---					
HEBP1	50865	broad.mit.edu	37	12	13142224	13142225	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:13142224_13142225insC	ENST00000536942.1	-	2	353_354	c.203_204insG	c.(202-204)gacfs	p.D68fs	HEBP1_ENST00000014930.4_Frame_Shift_Ins_p.D68fs			Q9NRV9	HEBP1_HUMAN	heme binding protein 1	68					circadian rhythm	extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(1)|urinary_tract(1)	7		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.153)		TGTCATTGGTGCCCCCCGCATA	0.554													19	1095	---	---	---	---					
GRIN2B	2904	broad.mit.edu	37	12	14019043	14019044	+	Frame_Shift_Ins	INS	-	-	G	rs77738206		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:14019043_14019044insG	ENST00000279593.3	-	2	308_309	c.99_100insC	c.(97-102)ccgcatfs	p.H34fs		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	34					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATGCCAATGCTGGGGGGGCTCT	0.589													13	174	---	---	---	---					
GUCY2C	2984	broad.mit.edu	37	12	14825856	14825857	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:14825856_14825857insC	ENST00000261170.3	-	9	1256_1257	c.1120_1121insG	c.(1120-1122)tgtfs	p.C374fs	RP11-174G6.1_ENST00000501178.2_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	374					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						ACTGTCAACATCCCCCCAGTCA	0.470													10	449	---	---	---	---					
WBP11	51729	broad.mit.edu	37	12	14940365	14940366	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:14940365_14940366insG	ENST00000261167.2	-	12	1792_1793	c.1559_1560insC	c.(1558-1560)cggfs	p.R520fs	WBP11_ENST00000537574.1_Frame_Shift_Ins_p.R486fs	NM_016312.2	NP_057396.1	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	520	Pro-rich.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding	p.G521fs*28(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)	30						GGAACAGCCCAGGGGGGGCAGG	0.550													10	310	---	---	---	---					
PCBP2	5094	broad.mit.edu	37	12	53856277	53856278	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:53856277_53856278insC	ENST00000603815.1	+	8	867_868	c.517_518insC	c.(517-519)cccfs	p.P173fs	PCBP2_ENST00000549863.1_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000548933.1_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000546463.1_Splice_Site_p.P169_splice|PCBP2_ENST00000552296.2_Splice_Site_p.P169_splice|PCBP2_ENST00000447282.1_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000359462.5_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000552819.1_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000541275.1_Splice_Site_p.P169_splice|RP11-793H13.8_ENST00000547717.1_RNA|PCBP2_ENST00000437231.1_Splice_Site_p.P169_splice|PCBP2_ENST00000439930.3_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000455667.3_Splice_Site_p.P169_splice|PCBP2_ENST00000359282.5_Splice_Site_p.P169_splice	NM_001128911.1|NM_001128912.1|NM_005016.5|NM_031989.4	NP_001122383.1|NP_001122384.1|NP_005007.2|NP_114366.1	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2	173					innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15						TCTCTCCCAGTCCCCCCCGAAG	0.500													10	241	---	---	---	---					
PDE1B	5153	broad.mit.edu	37	12	54971059	54971060	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:54971059_54971060insC	ENST00000243052.3	+	15	1994_1995	c.1558_1559insC	c.(1558-1560)cccfs	p.P520fs	PPP1R1A_ENST00000547431.1_3'UTR|PDE1B_ENST00000394277.3_3'UTR|PDE1B_ENST00000538346.1_Frame_Shift_Ins_p.P479fs|PDE1B_ENST00000550620.1_Frame_Shift_Ins_p.P500fs	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	520					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						TGAAGAAGAGGCCCCCCCATCC	0.559													12	657	---	---	---	---					
OR6C4	341418	broad.mit.edu	37	12	55945453	55945454	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:55945453_55945454insG	ENST00000394256.2	+	1	471_472	c.443_444insG	c.(442-444)tggfs	p.W148fs	RP11-110A12.2_ENST00000555138.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA	NM_001005494.1	NP_001005494.1	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C, member 4	148					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	11						TGCTCCTGGTTGGGGGGATTCC	0.455													9	554	---	---	---	---					
DGKA	1606	broad.mit.edu	37	12	56347513	56347514	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:56347513_56347514insC	ENST00000331886.5	+	24	2623_2624	c.2169_2170insC	c.(2167-2172)ccccccfs	p.PP723fs	DGKA_ENST00000549079.2_3'UTR|DGKA_ENST00000394147.1_Frame_Shift_Ins_p.PP723fs|DGKA_ENST00000551156.1_Frame_Shift_Ins_p.PP723fs	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	723					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	TCATGGGCCCACCCCCCCGCTC	0.579													11	325	---	---	---	---					
IKZF4	64375	broad.mit.edu	37	12	56429092	56429093	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:56429092_56429093insG	ENST00000262032.5	+	12	2102_2103	c.1735_1736insG	c.(1735-1737)gggfs	p.G579fs	IKZF4_ENST00000547791.1_Frame_Shift_Ins_p.G534fs|IKZF4_ENST00000547167.1_Frame_Shift_Ins_p.G579fs|IKZF4_ENST00000431367.2_Frame_Shift_Ins_p.G477fs|RP11-603J24.4_ENST00000551846.1_RNA			Q9H2S9	IKZF4_HUMAN	IKAROS family zinc finger 4 (Eos)	579					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|lung(3)|ovary(1)|prostate(1)	8			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			CCACATTGTCCGGGGGGAGCAT	0.554													12	869	---	---	---	---					
STAT2	6773	broad.mit.edu	37	12	56742816	56742817	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:56742816_56742817insG	ENST00000314128.4	-	17	1490_1491	c.1467_1468insC	c.(1465-1470)ccaggcfs	p.G490fs	STAT2_ENST00000557235.1_Frame_Shift_Ins_p.G486fs|STAT2_ENST00000556539.1_5'UTR|STAT2_ENST00000418572.2_3'UTR			P52630	STAT2_HUMAN	signal transducer and activator of transcription 2, 113kDa	490					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|skin(3)	31						CAGGGGGCCTTGGGGGGGTTGG	0.594													11	276	---	---	---	---					
STAT6	6778	broad.mit.edu	37	12	57499093	57499094	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:57499093_57499094insG	ENST00000300134.3	-	9	1166_1167	c.841_842insC	c.(841-843)ggtfs	p.G281fs	STAT6_ENST00000454075.3_Frame_Shift_Ins_p.G281fs|STAT6_ENST00000537215.2_Frame_Shift_Ins_p.G171fs|STAT6_ENST00000556155.1_Frame_Shift_Ins_p.G281fs|STAT6_ENST00000543873.2_Frame_Shift_Ins_p.G281fs|STAT6_ENST00000538913.2_Frame_Shift_Ins_p.G171fs	NM_001178078.1|NM_003153.4	NP_001171549.1|NP_003144.3	P42226	STAT6_HUMAN	signal transducer and activator of transcription 6, interleukin-4 induced	281					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(2)|lung(8)|ovary(4)|skin(1)	28						CTTCAGTACCTGGGGGGGCTGC	0.639													11	169	---	---	---	---					
KIF5A	3798	broad.mit.edu	37	12	57972047	57972048	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:57972047_57972048insG	ENST00000455537.2	+	23	2734_2735	c.2460_2461insG	c.(2458-2463)agggggfs	p.RG820fs	KIF5A_ENST00000286452.5_Frame_Shift_Ins_p.RG731fs	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	820					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						CCGAAGACAGTGGGGGGATTCA	0.505													10	1087	---	---	---	---					
CYP27B1	1594	broad.mit.edu	37	12	58160653	58160654	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:58160653_58160654insC	ENST00000228606.4	-	1	380_381	c.171_172insG	c.(169-174)ggtgtcfs	p.V58fs	RP11-571M6.13_ENST00000546609.1_RNA	NM_000785.3	NP_000776.1	O15528	CP27B_HUMAN	cytochrome P450, family 27, subfamily B, polypeptide 1	58					bone mineralization|calcium ion homeostasis|calcium ion transport|decidualization|G1 to G0 transition|hormone biosynthetic process|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of keratinocyte differentiation|positive regulation of vitamin D 24-hydroxylase activity|positive regulation of vitamin D receptor signaling pathway|regulation of bone mineralization|response to estrogen stimulus|response to interferon-gamma|response to lipopolysaccharide|response to tumor necrosis factor|response to vitamin D|vitamin D biosynthetic process|xenobiotic metabolic process	mitochondrial outer membrane	calcidiol 1-monooxygenase activity|electron carrier activity|heme binding			central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|urinary_tract(1)	15	all_cancers(7;8.09e-80)|Lung NSC(6;2.26e-27)|all_lung(6;1.99e-25)|all_epithelial(6;3.62e-18)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;1.97e-113)|all cancers(5;1.54e-78)|BRCA - Breast invasive adenocarcinoma(9;0.0294)		Calcidiol(DB00146)|Calcitriol(DB00136)|Ergocalciferol(DB00153)	AGCCTCGACAGCCCCCCCTTGC	0.599													10	136	---	---	---	---					
BEST3	144453	broad.mit.edu	37	12	70049361	70049362	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:70049361_70049362insG	ENST00000330891.5	-	10	1558_1559	c.1332_1333insC	c.(1330-1335)ccgggcfs	p.PG444fs	BEST3_ENST00000331471.4_Intron|BEST3_ENST00000488961.1_Frame_Shift_Ins_p.PG231fs|BEST3_ENST00000553096.1_Frame_Shift_Ins_p.PG338fs	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	444						chloride channel complex|plasma membrane	chloride channel activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GGTGAGGCCCTGGGGGGGTTTC	0.594													9	331	---	---	---	---					
NAV3	89795	broad.mit.edu	37	12	78400511	78400512	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:78400511_78400512insC	ENST00000397909.2	+	8	1366_1367	c.1193_1194insC	c.(1192-1194)cccfs	p.P398fs	NAV3_ENST00000536525.2_Frame_Shift_Ins_p.P398fs|NAV3_ENST00000228327.6_Frame_Shift_Ins_p.P398fs|NAV3_ENST00000266692.7_Frame_Shift_Ins_p.P398fs			Q8IVL0	NAV3_HUMAN	neuron navigator 3	398						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						ACTGCTTTACGCCCCCCGCAGC	0.495										HNSCC(70;0.22)			7	310	---	---	---	---					
UHRF1BP1L	23074	broad.mit.edu	37	12	100451839	100451840	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:100451839_100451840insG	ENST00000279907.7	-	14	3427_3428	c.3215_3216insC	c.(3214-3216)cgtfs	p.R1072fs	UHRF1BP1L_ENST00000545232.2_Frame_Shift_Ins_p.R722fs	NM_015054.1	NP_055869.1	A0JNW5	UH1BL_HUMAN	UHRF1 binding protein 1-like	1072										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						GTGTTCTAACTGGGGGGGTCTC	0.371													16	306	---	---	---	---					
SPIC	121599	broad.mit.edu	37	12	101876667	101876668	+	Frame_Shift_Ins	INS	-	-	G	rs140414335	byFrequency	TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:101876667_101876668insG	ENST00000551346.1	+	5	467_468	c.308_309insG	c.(307-309)aggfs	p.R103fs	SPIC_ENST00000299272.5_Frame_Shift_Ins_p.R103fs			Q8N5J4	SPIC_HUMAN	Spi-C transcription factor (Spi-1/PU.1 related)	103						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	22						CTCCAGCAAAAGGGGGGAAAAG	0.396													7	278	---	---	---	---					
HECTD4	283450	broad.mit.edu	37	12	112600859	112600860	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:112600859_112600860insG	ENST00000550722.1	-	75	13063_13064	c.12668_12669insC	c.(12667-12669)cgafs	p.R4223fs	HECTD4_ENST00000377560.5_Frame_Shift_Ins_p.R4197fs|HECTD4_ENST00000430131.2_Frame_Shift_Ins_p.R3947fs	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		CTGTGCCATCTGGGGGGGCGAT	0.629													28	317	---	---	---	---					
KSR2	283455	broad.mit.edu	37	12	117977604	117977605	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:117977604_117977605insG	ENST00000425217.1	-	10	1573_1574	c.1519_1520insC	c.(1519-1521)cccfs	p.P507fs	KSR2_ENST00000302438.5_Frame_Shift_Ins_p.P233fs|KSR2_ENST00000545002.1_5'UTR|KSR2_ENST00000339824.5_Frame_Shift_Ins_p.P536fs	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	536					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACTAGGAGGGAGGGGGGGTGCT	0.634													10	209	---	---	---	---					
SIRT4	23409	broad.mit.edu	37	12	120750293	120750294	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:120750293_120750294insG	ENST00000202967.4	+	3	591_592	c.532_533insG	c.(532-534)gggfs	p.G178fs	SIRT4_ENST00000537892.1_Intron	NM_012240.2	NP_036372.1	Q9Y6E7	SIRT4_HUMAN	sirtuin 4	178	Deacetylase sirtuin-type.				chromatin silencing|negative regulation of insulin secretion|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)	9	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACAGACTCCCCGGGGGGTGCTG	0.579													10	324	---	---	---	---					
VPS33A	65082	broad.mit.edu	37	12	122720396	122720397	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:122720396_122720397insC	ENST00000267199.4	-	11	1488_1489	c.1376_1377insG	c.(1375-1377)gagfs	p.E459fs	RP11-512M8.5_ENST00000535844.1_Frame_Shift_Ins_p.E420fs	NM_022916.4	NP_075067.2	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33 homolog A (S. cerevisiae)	459					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	28	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		AATTGTTTCTGCCCCCCGTCTG	0.495													7	367	---	---	---	---					
EP400	57634	broad.mit.edu	37	12	132466645	132466646	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr12:132466645_132466646insC	ENST00000333577.4	+	6	1768_1769	c.1659_1660insC	c.(1657-1662)atccccfs	p.IP553fs	EP400_ENST00000330386.6_Frame_Shift_Ins_p.IP517fs|EP400_ENST00000389561.2_Frame_Shift_Ins_p.IP517fs|EP400_ENST00000332482.4_Frame_Shift_Ins_p.IP480fs|EP400_ENST00000389562.2_Frame_Shift_Ins_p.IP516fs			Q96L91	EP400_HUMAN	E1A binding protein p400	553					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CAGGAGGAATGCCCCCCACGCC	0.589													7	476	---	---	---	---					
ATP12A	479	broad.mit.edu	37	13	25262563	25262564	+	Frame_Shift_Ins	INS	-	-	G	rs35191129		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr13:25262563_25262564insG	ENST00000218548.6	+	4	668_669	c.335_336insG	c.(334-336)gggfs	p.G112fs	ATP12A_ENST00000381946.3_Frame_Shift_Ins_p.G112fs	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	112					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding	p.V112V(1)		breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	AAGCAGATGGTGGGGGGGTTCT	0.584													87	2323	---	---	---	---					
WASF3	10810	broad.mit.edu	37	13	27255386	27255387	+	Frame_Shift_Ins	INS	-	-	C	rs141429361		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr13:27255386_27255387insC	ENST00000361042.4	+	8	1128_1129	c.903_904insC	c.(901-906)ccccccfs	p.PP301fs	WASF3_ENST00000335327.5_Frame_Shift_Ins_p.PP304fs			Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	304					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|pancreas(1)|prostate(2)|skin(2)	22	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		CTCAGCAGCCGCCCCCCCCGCC	0.678													9	93	---	---	---	---					
MEDAG	84935	broad.mit.edu	37	13	31495729	31495730	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr13:31495729_31495730insC	ENST00000380482.4	+	4	858_859	c.533_534insC	c.(532-534)tccfs	p.S178fs	TEX26-AS1_ENST00000585870.1_RNA|TEX26-AS1_ENST00000451495.2_RNA|TEX26-AS1_ENST00000590344.1_RNA|TEX26-AS1_ENST00000590721.1_RNA|TEX26-AS1_ENST00000592950.1_RNA|TEX26-AS1_ENST00000586973.1_RNA|TEX26-AS1_ENST00000593246.1_RNA|TEX26-AS1_ENST00000586464.1_RNA|TEX26-AS1_ENST00000588726.1_RNA	NM_032849.3	NP_116238.2			mesenteric estrogen-dependent adipogenesis																		AAGAATTTCTTCCCCCCAGGAA	0.356													8	357	---	---	---	---					
KL	9365	broad.mit.edu	37	13	33638205	33638206	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr13:33638205_33638206insT	ENST00000380099.3	+	5	2929_2930	c.2921_2922insT	c.(2920-2922)attfs	p.I974fs	KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	974					aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		ACTGAGTGCAGTTTTTTTCACA	0.376													7	259	---	---	---	---					
KBTBD6	89890	broad.mit.edu	37	13	41705321	41705322	+	Frame_Shift_Ins	INS	-	-	C	rs147771080		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr13:41705321_41705322insC	ENST00000379485.1	-	1	1560_1561	c.1326_1327insG	c.(1324-1329)gggagafs	p.R443fs	KBTBD6_ENST00000499385.2_Frame_Shift_Ins_p.R377fs	NM_152903.4	NP_690867.3	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain containing 6	443							protein binding			NS(1)|breast(1)|endometrium(8)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(4)|urinary_tract(4)	43		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		ATAGGGTCTCGCCCCCCCAAAA	0.470													19	413	---	---	---	---					
MYCBP2	23077	broad.mit.edu	37	13	77641916	77641917	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr13:77641916_77641917insG	ENST00000407578.2	-	71	12520_12521	c.12254_12255insC	c.(12253-12255)cgcfs	p.R4085fs	MYCBP2_ENST00000357337.6_Frame_Shift_Ins_p.R4047fs|MYCBP2_ENST00000544440.2_Frame_Shift_Ins_p.R4047fs	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	4047					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TGATATCTGCTGGGGGGAGGGA	0.436													8	679	---	---	---	---					
OR4N5	390437	broad.mit.edu	37	14	20612063	20612064	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr14:20612063_20612064insC	ENST00000333629.1	+	1	169_170	c.169_170insC	c.(169-171)cccfs	p.P57fs		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TGGGCTCACAGCCCCCCTCTAT	0.460													10	1038	---	---	---	---					
TRAV3	28690	broad.mit.edu	37	14	22192097	22192098	+	RNA	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr14:22192097_22192098insC	ENST00000390425.2	+	0	138_139																											GCTGGAAAGGACCCCCCCAATC	0.574													7	237	---	---	---	---					
ACIN1	22985	broad.mit.edu	37	14	23549377	23549378	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr14:23549377_23549378insG	ENST00000262710.1	-	6	1667_1668	c.1340_1341insC	c.(1339-1341)ggtfs	p.G447fs	ACIN1_ENST00000605057.1_Frame_Shift_Ins_p.G389fs|ACIN1_ENST00000555053.1_Frame_Shift_Ins_p.G447fs|ACIN1_ENST00000457657.1_Frame_Shift_Ins_p.G407fs	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	447			A -> P (in dbSNP:rs941719).		apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GAATGAGGACAGCGGGGGCTGG	0.500													7	151	---	---	---	---					
GALNT16	57452	broad.mit.edu	37	14	69800299	69800300	+	Frame_Shift_Ins	INS	-	-	G	rs144140025		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr14:69800299_69800300insG	ENST00000337827.4	+	9	1276_1277	c.949_950insG	c.(949-951)gggfs	p.G317fs	GALNT16_ENST00000553669.1_Frame_Shift_Ins_p.G317fs|GALNT16_ENST00000448469.3_Frame_Shift_Ins_p.G317fs	NM_001168368.1|NM_020692.2	NP_001161840.1|NP_065743.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16																		GATGGACATCTGGGGGGGAGAG	0.470													10	165	---	---	---	---					
ADAM21P1	145241	broad.mit.edu	37	14	70713512	70713535	+	RNA	DEL	TGGGAACGACTGATTTGTTTCCGT	TGGGAACGACTGATTTGTTTCCGT	-			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr14:70713512_70713535delTGGGAACGACTGATTTGTTTCCGT	ENST00000530196.1	-	0	983_1006					NR_003951.1																						ATGTTGTAGCTGGGAACGACTGATTTGTTTCCGTTGAGAGAAAT	0.362													8	165	---	---	---	---					
YLPM1	56252	broad.mit.edu	37	14	75248518	75248519	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr14:75248518_75248519insC	ENST00000325680.7	+	4	1896_1897	c.1772_1773insC	c.(1771-1773)cccfs	p.P591fs	YLPM1_ENST00000552421.1_Frame_Shift_Ins_p.P591fs|YLPM1_ENST00000238571.3_Intron	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CCACCAGTTCTCCCCCCACCTT	0.599													7	373	---	---	---	---					
SERPINA1	5265	broad.mit.edu	37	14	94844884	94844885	+	Frame_Shift_Ins	INS	-	-	G	rs143329723	by1000genomes	TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr14:94844884_94844885insG	ENST00000448921.1	-	7	1730_1731	c.1158_1159insC	c.(1156-1161)ccaggtfs	p.G387fs	SERPINA1_ENST00000440909.1_Frame_Shift_Ins_p.G387fs|SERPINA1_ENST00000449399.3_Frame_Shift_Ins_p.G387fs|SERPINA1_ENST00000404814.4_Frame_Shift_Ins_p.G387fs|SERPINA1_ENST00000393088.4_Frame_Shift_Ins_p.G387fs|SERPINA1_ENST00000355814.4_Frame_Shift_Ins_p.G387fs|SERPINA1_ENST00000437397.1_Frame_Shift_Ins_p.G387fs|SERPINA1_ENST00000393087.4_Frame_Shift_Ins_p.G387fs	NM_001002236.2|NM_001127701.1|NM_001127703.1|NM_001127704.1|NM_001127705.1	NP_001002236.1|NP_001121173.1|NP_001121175.1|NP_001121176.1|NP_001121177.1	P01009	A1AT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	387	RCL.		E -> K (in Christchurch).		acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|skin(6)|stomach(1)	24		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	AACTTGACCTCGGGGGGGATAG	0.490													8	132	---	---	---	---					
IGHG4	3503	broad.mit.edu	37	14	106091519	106091520	+	RNA	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr14:106091519_106091520insG	ENST00000390543.2	-	0	373_374																											CCTTGGGTTTTGGGGGGAACAG	0.619													7	367	---	---	---	---					
IGHV4-39	28394	broad.mit.edu	37	14	106877817	106877819	+	RNA	DEL	ACT	ACT	-	rs113800876		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr14:106877817_106877819delACT	ENST00000390619.2	-	0	224_226																											CCCAGTAGTAACTACTACTGCTG	0.596													20	56	---	---	---	---					
C15orf52	388115	broad.mit.edu	37	15	40630771	40630772	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr15:40630771_40630772insG	ENST00000559313.1	-	5	624_625	c.609_610insC	c.(607-612)cccgcafs	p.A204fs		NM_207380.2	NP_997263.2	Q6ZUT6	CO052_HUMAN	chromosome 15 open reading frame 52	204										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	19		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		GCCACCTGCGTGGGGGGGCTTC	0.584											OREG0023060	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	169	---	---	---	---					
HERC1	8925	broad.mit.edu	37	15	63918305	63918306	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr15:63918305_63918306insG	ENST00000443617.2	-	71	13240_13241	c.13153_13154insC	c.(13153-13155)gtafs	p.V4385fs		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	4385					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						CGCCCCATACTGGGGGGGCACT	0.559													7	75	---	---	---	---					
IGF1R	3480	broad.mit.edu	37	15	99251108	99251109	+	Frame_Shift_Ins	INS	-	-	G	rs121912426		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr15:99251108_99251109insG	ENST00000268035.6	+	2	1023_1024	c.412_413insG	c.(412-414)gggfs	p.G138fs	IGF1R_ENST00000558762.1_Frame_Shift_Ins_p.G138fs	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	138			R -> Q (in IGF1RES; has decreased IGF1R function).		anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	GAACATTACTCGGGGGGCCATC	0.510													7	266	---	---	---	---					
ACSM2A	123876	broad.mit.edu	37	16	20489924	20489925	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:20489924_20489925insC	ENST00000573854.1	+	10	1320_1321	c.1206_1207insC	c.(1204-1209)ctccccfs	p.LP402fs	ACSM2A_ENST00000219054.6_Frame_Shift_Ins_p.LP402fs|ACSM2A_ENST00000575690.1_Frame_Shift_Ins_p.LP402fs|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000536134.1_Frame_Shift_Ins_p.LP174fs|ACSM2A_ENST00000396104.2_Frame_Shift_Ins_p.LP402fs|ACSM2A_ENST00000417235.2_Frame_Shift_Ins_p.LP323fs	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	402					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						GCAACGTCCTGCCCCCCGGCAC	0.505													7	426	---	---	---	---					
ACSM2B	348158	broad.mit.edu	37	16	20556547	20556548	+	Frame_Shift_Ins	INS	-	-	G	rs146499503		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:20556547_20556548insG	ENST00000329697.6	-	10	1380_1381	c.1212_1213insC	c.(1210-1215)ccgcacfs	p.H405fs	ACSM2B_ENST00000565322.1_Frame_Shift_Ins_p.H326fs|ACSM2B_ENST00000565232.1_Frame_Shift_Ins_p.H405fs|ACSM2B_ENST00000567288.1_5'UTR|ACSM2B_ENST00000567001.1_Frame_Shift_Ins_p.H405fs	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	405					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						CCTTCTGTGCCGGGGGGCAGGA	0.515													14	447	---	---	---	---					
DNAH3	55567	broad.mit.edu	37	16	20966297	20966298	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:20966297_20966298insG	ENST00000261383.3	-	55	10907_10908	c.10908_10909insC	c.(10906-10911)ccaaggfs	p.R3637fs	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3637	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CGGAGCCCTTTGGGGGGCTCAT	0.510													9	486	---	---	---	---					
DNAH3	55567	broad.mit.edu	37	16	20976647	20976648	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:20976647_20976648insG	ENST00000261383.3	-	53	8557_8558	c.8558_8559insC	c.(8557-8559)cctfs	p.P2853fs	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2853	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TCATGGTCAGTGGGGGGATGTT	0.460													9	695	---	---	---	---					
TNRC6A	27327	broad.mit.edu	37	16	24802365	24802366	+	Frame_Shift_Ins	INS	-	-	G	rs139212478	byFrequency	TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:24802365_24802366insG	ENST00000395799.3	+	6	2531_2532	c.2402_2403insG	c.(2401-2403)cggfs	p.R801fs	TNRC6A_ENST00000315183.7_Frame_Shift_Ins_p.R801fs	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	801	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		TCAAACTGCCAGGGGGGGTGGG	0.510													11	126	---	---	---	---					
ITGAL	3683	broad.mit.edu	37	16	30531243	30531244	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:30531243_30531244insG	ENST00000356798.6	+	30	3474_3475	c.3294_3295insG	c.(3292-3297)atggggfs	p.MG1098fs	ITGAL_ENST00000433423.2_Frame_Shift_Ins_p.MG332fs|ITGAL_ENST00000358164.5_Frame_Shift_Ins_p.MG1014fs	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	1098					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	TGAGCGGCATCGGGGGGCTGCT	0.599													9	569	---	---	---	---					
ZNF668	79759	broad.mit.edu	37	16	31072705	31072706	+	Frame_Shift_Ins	INS	-	-	G	rs77284397		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:31072705_31072706insG	ENST00000538906.1	-	3	2327_2328	c.1543_1544insC	c.(1543-1545)gttfs	p.V515fs	ZNF668_ENST00000300849.4_Frame_Shift_Ins_p.V515fs|ZNF668_ENST00000394983.2_Frame_Shift_Ins_p.V515fs|ZNF668_ENST00000426488.2_Frame_Shift_Ins_p.V538fs|ZNF668_ENST00000535577.1_Frame_Shift_Ins_p.V515fs|ZNF668_ENST00000539836.3_Frame_Shift_Ins_p.V538fs	NM_001172668.1	NP_001166139.1	Q96K58	ZN668_HUMAN	zinc finger protein 668	515					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						GCACACAAACTGGGGGGGCTTC	0.663													11	222	---	---	---	---					
CES1	1066	broad.mit.edu	37	16	55857568	55857569	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:55857568_55857569insC	ENST00000422046.2	-	4	710_711	c.429_430insG	c.(427-432)ggtgatfs	p.D144fs	CES1_ENST00000361503.4_Frame_Shift_Ins_p.D144fs|CES1_ENST00000360526.3_Frame_Shift_Ins_p.D145fs|CES1_ENST00000566555.1_5'UTR			P23141	EST1_HUMAN	carboxylesterase 1	144					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity								all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	CCCACCATCAGCCCCCCTCCGT	0.559													7	452	---	---	---	---					
MT4	84560	broad.mit.edu	37	16	56602768	56602769	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:56602768_56602769insC	ENST00000219162.3	+	3	193_194	c.113_114insC	c.(112-114)tccfs	p.S38fs		NM_032935.2	NP_116324.1	P47944	MT4_HUMAN	metallothionein 4	38						cytoplasm	copper ion binding|zinc ion binding			ovary(1)|upper_aerodigestive_tract(1)	2						TGTCCCTGCTGCCCCCCGGGCT	0.599													30	1477	---	---	---	---					
GPR114	221188	broad.mit.edu	37	16	57600565	57600566	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:57600565_57600566insG	ENST00000340339.4	+	7	1124_1125	c.601_602insG	c.(601-603)gggfs	p.G201fs	GPR114_ENST00000394361.4_3'UTR|GPR114_ENST00000349457.3_Frame_Shift_Ins_p.G201fs	NM_153837.1	NP_722579.1	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114	201	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.W204fs*4(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(5)|ovary(2)|stomach(1)|urinary_tract(1)	23						GAAACAGCCCTGGGGGGGCTGG	0.604													9	125	---	---	---	---					
C16orf70	80262	broad.mit.edu	37	16	67180988	67180989	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:67180988_67180989insC	ENST00000219139.3	+	16	1411_1412	c.1223_1224insC	c.(1222-1224)gccfs	p.A408fs	C16orf70_ENST00000569600.1_Frame_Shift_Ins_p.A408fs	NM_025187.3	NP_079463.2	Q9BSU1	CP070_HUMAN	chromosome 16 open reading frame 70	408								p.R411fs*4(1)		cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(3)|skin(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0017)|Epithelial(162;0.00655)|all cancers(182;0.0579)		ACCCTGTATGGCCCCCCCAGGC	0.594													11	432	---	---	---	---					
KIAA0895L	653319	broad.mit.edu	37	16	67213789	67213790	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:67213789_67213790insC	ENST00000290881.7	-	4	1568_1569	c.642_643insG	c.(640-645)ggagctfs	p.A215fs	KIAA0895L_ENST00000563902.1_Frame_Shift_Ins_p.A215fs|KIAA0895L_ENST00000561621.1_Frame_Shift_Ins_p.A215fs|KIAA0895L_ENST00000563831.2_Intron			Q68EN5	K895L_HUMAN	KIAA0895-like	215										breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|skin(1)	17						GTGAGCAGCTGCCCCCCAGTGG	0.569													10	298	---	---	---	---					
SLC9A5	6553	broad.mit.edu	37	16	67290903	67290904	+	Frame_Shift_Ins	INS	-	-	G	rs35182421		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:67290903_67290904insG	ENST00000299798.11	+	7	1287_1288	c.1222_1223insG	c.(1222-1224)gggfs	p.G408fs		NM_004594.2	NP_004585.1	Q14940	SL9A5_HUMAN	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	408					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity	p.R408W(1)		breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		TGGGGGCCTGCGGGGGGCTGTG	0.559													7	250	---	---	---	---					
KCTD19	146212	broad.mit.edu	37	16	67325657	67325658	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:67325657_67325658insG	ENST00000304372.5	-	13	2356_2357	c.2301_2302insC	c.(2299-2304)cctggtfs	p.G768fs		NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	768						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		CTGCCCACCACGGGGGGGTGAG	0.574													13	227	---	---	---	---					
ZFHX3	463	broad.mit.edu	37	16	72822585	72822586	+	Frame_Shift_Ins	INS	-	-	G	rs66799632		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:72822585_72822586insG	ENST00000268489.5	-	10	10261_10262	c.9589_9590insC	c.(9589-9591)gcafs	p.A3197fs	ZFHX3_ENST00000397992.5_Frame_Shift_Ins_p.A2283fs	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3197	Poly-Gln.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				ctgctgctgctgGGGGGGTTGC	0.658													8	274	---	---	---	---					
NPIPB15	440348	broad.mit.edu	37	16	74423894	74423895	+	Splice_Site	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:74423894_74423895insC	ENST00000429990.1	+	6	704_705	c.606_splice	c.e6-1	p.T203_splice						nuclear pore complex interacting protein family, member B15																		CTTTTTCAGATCCCCCCTTCTG	0.455													10	1246	---	---	---	---					
RFWD3	55159	broad.mit.edu	37	16	74660348	74660349	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr16:74660348_74660349insA	ENST00000361070.4	-	12	2170_2171	c.2073_2074insT	c.(2071-2076)ttgaggfs	p.LR691fs	RFWD3_ENST00000571750.1_Frame_Shift_Ins_p.LR691fs	NM_018124.3	NP_060594.3	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	691					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	26						GTAGGTCCTCCAAAAAATGTAT	0.450													8	630	---	---	---	---					
RPA1	6117	broad.mit.edu	37	17	1782982	1782983	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:1782982_1782983insG	ENST00000254719.5	+	11	1191_1192	c.1081_1082insG	c.(1081-1083)gggfs	p.G361fs		NM_002945.3	NP_002936.1	P27694	RFA1_HUMAN	replication protein A1, 70kDa	361					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding			breast(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(2)	10						TGCTACACTGTGGGGGGAAGAT	0.530								Nucleotide excision repair (NER)					12	1079	---	---	---	---					
C17orf85	55421	broad.mit.edu	37	17	3716453	3716454	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:3716453_3716454insC	ENST00000158149.3	-	14	1802_1803	c.907_908insG	c.(907-909)tctfs	p.S303fs	C17orf85_ENST00000389005.4_Frame_Shift_Ins_p.S583fs			Q53F19	CQ085_HUMAN	chromosome 17 open reading frame 85	583							nucleotide binding	p.A303fs*2(1)		endometrium(2)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (3;0.0725)		CTTAATCAGAGCCCCCCATGCC	0.505													7	521	---	---	---	---					
WSCD1	23302	broad.mit.edu	37	17	6012978	6012979	+	Frame_Shift_Ins	INS	-	-	C	rs41314099	byFrequency	TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:6012978_6012979insC	ENST00000574946.1	+	6	1291_1292	c.901_902insC	c.(901-903)cccfs	p.P301fs	WSCD1_ENST00000317744.5_Frame_Shift_Ins_p.P301fs|WSCD1_ENST00000539421.1_Frame_Shift_Ins_p.P301fs|WSCD1_ENST00000574232.1_Frame_Shift_Ins_p.P301fs|WSCD1_ENST00000573634.1_Frame_Shift_Ins_p.P185fs			Q658N2	WSCD1_HUMAN	WSC domain containing 1	301	WSC 2.					integral to membrane	sulfotransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)	35						TGCTTACCCTACCCCCCGGTTC	0.564													23	1473	---	---	---	---					
ALOX12	239	broad.mit.edu	37	17	6904973	6904974	+	Frame_Shift_Ins	INS	-	-	C	rs138651024	by1000genomes	TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:6904973_6904974insC	ENST00000251535.6	+	8	1057_1058	c.1004_1005insC	c.(1003-1005)gccfs	p.A335fs	AC027763.2_ENST00000399541.2_Intron|RP11-589P10.7_ENST00000572547.1_RNA|AC027763.2_ENST00000575727.1_Intron|AC027763.2_ENST00000399540.2_3'UTR|AC027763.2_ENST00000574377.1_Intron	NM_000697.2	NP_000688.2	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	335	Lipoxygenase.				anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)|urinary_tract(1)	19						CTGCCCTCAGACCCCCCACTTG	0.515													7	897	---	---	---	---					
PLSCR3	57048	broad.mit.edu	37	17	7294058	7294059	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:7294058_7294059insC	ENST00000535512.1	-	10	1742_1743	c.725_726insG	c.(724-726)gctfs	p.A242fs	PLSCR3_ENST00000576362.1_Frame_Shift_Ins_p.A218fs|C17orf61-PLSCR3_ENST00000573331.1_3'UTR|PLSCR3_ENST00000576201.1_Frame_Shift_Ins_p.A242fs|PLSCR3_ENST00000574401.1_Frame_Shift_Ins_p.A242fs|PLSCR3_ENST00000324822.11_Frame_Shift_Ins_p.A242fs			Q9NRY6	PLS3_HUMAN	phospholipid scramblase 3	242					phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|calcium-dependent protein binding|phospholipid scramblase activity|SH3 domain binding			endometrium(1)|kidney(2)|urinary_tract(1)	4		Prostate(122;0.173)				CTCGGACCAGGCCCCCCCACTG	0.614													24	528	---	---	---	---					
EFNB3	1949	broad.mit.edu	37	17	7612855	7612856	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:7612855_7612856insC	ENST00000226091.2	+	5	1381_1382	c.984_985insC	c.(982-987)ggccccfs	p.GP328fs		NM_001406.3	NP_001397.1	Q15768	EFNB3_HUMAN	ephrin-B3	328					cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	8		all_cancers(10;1.14e-06)|Prostate(122;0.081)				TGCAGGATGGGCCCCCCCAGAG	0.574													11	322	---	---	---	---					
CHD3	1107	broad.mit.edu	37	17	7798764	7798765	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:7798764_7798765insC	ENST00000380358.4	+	10	1789_1790	c.1788_1789insC	c.(1786-1791)ccccccfs	p.PP596fs	CHD3_ENST00000358181.4_Frame_Shift_Ins_p.PP537fs|CHD3_ENST00000330494.7_Frame_Shift_Ins_p.PP537fs	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	537					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				CAGATGTCCCACCCCCCCGTCC	0.574													42	571	---	---	---	---					
UBBP4	23666	broad.mit.edu	37	17	21731033	21731034	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:21731033_21731034insC	ENST00000584755.1	+	2	732_733	c.335_336insC	c.(334-336)accfs	p.T112fs	UBBP4_ENST00000578713.1_Frame_Shift_Ins_p.T112fs|UBBP4_ENST00000583708.1_3'UTR|UBBP4_ENST00000584398.1_3'UTR																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						AAAGAAGGCATCCCCCCCGACC	0.540													9	166	---	---	---	---					
PHF12	57649	broad.mit.edu	37	17	27233908	27233909	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:27233908_27233909insG	ENST00000332830.4	-	14	3455_3456	c.2645_2646insC	c.(2644-2646)cagfs	p.Q882fs	PHF12_ENST00000577226.1_3'UTR	NM_001033561.1	NP_001028733.1	Q96QT6	PHF12_HUMAN	PHD finger protein 12	882					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			CAATACTGCTTGGGGGGGTTGG	0.510													7	271	---	---	---	---					
SSH2	85464	broad.mit.edu	37	17	27959374	27959375	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:27959374_27959375insG	ENST00000269033.3	-	15	2907_2908	c.2756_2757insC	c.(2755-2757)cgafs	p.R919fs	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Frame_Shift_Ins_p.R946fs	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	919					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						ATGAATGTTCTGGGGGGGCTTC	0.480													40	997	---	---	---	---					
NF1	4763	broad.mit.edu	37	17	29553477	29553478	+	Frame_Shift_Ins	INS	-	-	C	rs145092683		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:29553477_29553478insC	ENST00000358273.4	+	18	2409_2410	c.2026_2027insC	c.(2026-2028)cccfs	p.P676fs	NF1_ENST00000356175.3_Frame_Shift_Ins_p.P676fs	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	676					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)|p.P678fs*10(1)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ATGCAGCGGAACCCCCCCGATT	0.460			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			9	176	---	---	---	---					
NF1	4763	broad.mit.edu	37	17	29683557	29683558	+	Frame_Shift_Ins	INS	-	-	C	rs66883224		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:29683557_29683558insC	ENST00000358273.4	+	52	8078_8079	c.7695_7696insC	c.(7693-7698)acccccfs	p.TP2565fs	NF1_ENST00000444181.2_Frame_Shift_Ins_p.TP358fs|NF1_ENST00000417592.2_3'UTR|NF1_ENST00000356175.3_Frame_Shift_Ins_p.TP2544fs	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	2565					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GGATCACAACACCCCCCAAAAT	0.366			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			11	232	---	---	---	---					
RAB11FIP4	84440	broad.mit.edu	37	17	29758897	29758898	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:29758897_29758898insG	ENST00000325874.8	+	2	455_456	c.226_227insG	c.(226-228)gggfs	p.G76fs		NM_032932.3	NP_116321.2	Q86YS3	RFIP4_HUMAN	RAB11 family interacting protein 4 (class II)	76	EF-hand.				cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding	p.?(1)		endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)				GGACTTTTGCCGGGGGGTGTTC	0.579													11	373	---	---	---	---					
ACACA	31	broad.mit.edu	37	17	35600370	35600371	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:35600370_35600371insG	ENST00000353139.5	-	22	3328_3329	c.2847_2848insC	c.(2845-2850)ccatgtfs	p.C950fs	ACACA_ENST00000394406.2_Frame_Shift_Ins_p.C913fs|ACACA_ENST00000360679.3_Frame_Shift_Ins_p.C855fs|ACACA_ENST00000335166.5_Frame_Shift_Ins_p.C835fs	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	913					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TTCTCCACATTGGGGGGAATGC	0.470													10	1042	---	---	---	---					
PCGF2	7703	broad.mit.edu	37	17	36896586	36896587	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:36896586_36896587insC	ENST00000580830.1	-	4	770_771	c.69_70insG	c.(67-72)ggacttfs	p.L24fs	PCGF2_ENST00000360797.2_Frame_Shift_Ins_p.L24fs|PCGF2_ENST00000579882.1_Frame_Shift_Ins_p.L24fs|PCGF2_ENST00000581345.1_Frame_Shift_Ins_p.L24fs|PCGF2_ENST00000585100.1_Frame_Shift_Ins_p.L24fs|PCGF2_ENST00000578109.1_Intron			P35227	PCGF2_HUMAN	polycomb group ring finger 2	24					negative regulation of transcription from RNA polymerase II promoter	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	10	Breast(7;9.07e-22)					TCGATGAAGTACCCCCCGCAGA	0.629													7	475	---	---	---	---					
MIEN1	84299	broad.mit.edu	37	17	37885932	37885935	+	Frame_Shift_Del	DEL	ACTC	ACTC	-			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:37885932_37885935delACTC	ENST00000577810.1	-	3	281_284	c.267_270delGAGT	c.(265-270)gtfs	p.VS89fs	MIEN1_ENST00000474210.1_Intron|ERBB2_ENST00000584888.1_Intron|MIEN1_ENST00000394231.3_Intron	NM_032339.3	NP_115715.3	Q9BRT3	CQ037_HUMAN	migration and invasion enhancer 1	89					cell redox homeostasis	cytosol|membrane	selenium binding										CGCTGTAAATACTCACATCTTTCT	0.485													23	842	---	---	---	---					
TOP2A	7153	broad.mit.edu	37	17	38552660	38552661	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:38552660_38552661insC	ENST00000423485.1	-	28	3752_3753	c.3594_3595insG	c.(3592-3597)ggaggcfs	p.G1199fs		NM_001067.3	NP_001058.2	P11388	TOP2A_HUMAN	topoisomerase (DNA) II alpha 170kDa	1199					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(9)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	39		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	CCCTTGGCCTTCCCCCCTTTCC	0.426													7	345	---	---	---	---					
KCNH4	23415	broad.mit.edu	37	17	40328258	40328259	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:40328258_40328259insC	ENST00000264661.3	-	5	974_975	c.642_643insG	c.(640-645)ggctcgfs	p.S215fs	KCNH4_ENST00000607371.1_Frame_Shift_Ins_p.S215fs	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	215					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AGGCAGCGAGACCCCCCCACGG	0.604													24	667	---	---	---	---					
TUBG1	7283	broad.mit.edu	37	17	40764471	40764472	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:40764471_40764472insG	ENST00000251413.3	+	5	488_489	c.426_427insG	c.(424-429)gcggggfs	p.AG142fs		NM_001070.4	NP_001061.2	P23258	TBG1_HUMAN	tubulin, gamma 1	142					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		ACTCCATTGCTGGGGGGACAGG	0.505													7	718	---	---	---	---					
OSBPL7	114881	broad.mit.edu	37	17	45886342	45886343	+	Frame_Shift_Ins	INS	-	-	G	rs143462261		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:45886342_45886343insG	ENST00000007414.3	-	21	2375_2376	c.2184_2185insC	c.(2182-2187)ccaccafs	p.P729fs	OSBPL7_ENST00000392507.3_Frame_Shift_Ins_p.P729fs	NM_145798.2	NP_665741.1	Q9BZF2	OSBL7_HUMAN	oxysterol binding protein-like 7	729					lipid transport		lipid binding	p.D729fs*3(1)		autonomic_ganglia(1)|endometrium(6)|kidney(2)|large_intestine(5)|liver(2)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32						CGCTCATGGTCGGGGGGCATTG	0.619													9	550	---	---	---	---					
MRPL10	124995	broad.mit.edu	37	17	45905873	45905874	+	Frame_Shift_Ins	INS	-	-	G	rs147331240		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:45905873_45905874insG	ENST00000290208.7	-	2	697_698	c.245_246insC	c.(244-246)ccafs	p.P82fs	MRPL10_ENST00000351111.2_Frame_Shift_Ins_p.P72fs|MRPL10_ENST00000414011.1_Frame_Shift_Ins_p.P82fs			Q7Z7H8	RM10_HUMAN	mitochondrial ribosomal protein L10	72					ribosome biogenesis|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			endometrium(3)|large_intestine(1)|lung(3)|ovary(1)	8						TTACCTCCTGTGGGGGGCTGGG	0.525													7	325	---	---	---	---					
SP2	6668	broad.mit.edu	37	17	45994141	45994142	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:45994141_45994142insC	ENST00000376741.4	+	3	841_842	c.704_705insC	c.(703-705)accfs	p.T235fs	AC003665.1_ENST00000451140.2_RNA|AC003665.1_ENST00000585280.1_RNA|AC003665.1_ENST00000433001.1_RNA|AC003665.1_ENST00000411573.2_RNA	NM_003110.5	NP_003101.3	Q02086	SP2_HUMAN	Sp2 transcription factor	235					immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|histone deacetylase binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	13						CTCACTGAAAGCCCCCCAACCC	0.609													8	605	---	---	---	---					
CA10	56934	broad.mit.edu	37	17	50008356	50008357	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:50008356_50008357insC	ENST00000451037.2	-	3	1212_1213	c.272_273insG	c.(271-273)gagfs	p.E91fs	CA10_ENST00000442502.2_Frame_Shift_Ins_p.E91fs|CA10_ENST00000570565.1_Frame_Shift_Ins_p.E16fs|CA10_ENST00000285273.4_Frame_Shift_Ins_p.E91fs|CA10_ENST00000340813.6_Frame_Shift_Ins_p.E97fs	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	91					brain development			p.G91V(1)		cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TTACCTTCCTGCCCCCCGTGTT	0.490													18	1244	---	---	---	---					
SCN4A	6329	broad.mit.edu	37	17	62049212	62049213	+	Splice_Site	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:62049212_62049213insG	ENST00000578147.1	-	4	559		c.e4-2		SCN4A_ENST00000435607.1_Splice_Site			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit						muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	AAGGTGTACCTGGGGGGGAGAG	0.589													8	146	---	---	---	---					
AXIN2	8313	broad.mit.edu	37	17	63532584	63532585	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:63532584_63532585insC	ENST00000307078.5	-	8	2307_2308	c.1994_1995insG	c.(1993-1995)gaafs	p.E665fs	AXIN2_ENST00000375702.5_Frame_Shift_Ins_p.E600fs	NM_004655.3	NP_004646.3	Q9Y2T1	AXIN2_HUMAN	axin 2	665					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	34						GCCCGCTGTTGCCCCCCCACAG	0.658									Oligodontia, Ectodermal Dysplasia and Colorectal Polyp syndrome				9	80	---	---	---	---					
SLC16A6	9120	broad.mit.edu	37	17	66270149	66270150	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:66270149_66270150insC	ENST00000327268.4	-	4	458_459	c.294_295insG	c.(292-297)ggtactfs	p.T99fs	ARSG_ENST00000448504.2_Intron|SLC16A6_ENST00000580666.1_Frame_Shift_Ins_p.T99fs	NM_001174166.1	NP_001167637.1	O15403	MOT7_HUMAN	solute carrier family 16, member 6	99						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			large_intestine(3)|lung(8)|prostate(1)|skin(1)|urinary_tract(2)	15	all_cancers(12;1.24e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)		Pyruvic acid(DB00119)	CTGACAAGTAGCCCCCCCAACA	0.535													9	140	---	---	---	---					
ABCA6	23460	broad.mit.edu	37	17	67083603	67083604	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:67083603_67083604insG	ENST00000284425.2	-	29	3883_3884	c.3709_3710insC	c.(3709-3711)aagfs	p.K1237fs	ABCA6_ENST00000446604.2_5'UTR	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	1237					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					ATCTCTACTTTGGGGGGAAATT	0.376													22	1428	---	---	---	---					
FAM104A	84923	broad.mit.edu	37	17	71223356	71223357	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:71223356_71223357insG	ENST00000405159.3	-	2	332_333	c.268_269insC	c.(268-270)gacfs	p.D90fs	FAM104A_ENST00000403627.3_Frame_Shift_Ins_p.D90fs|FAM104A_ENST00000581110.1_Intron|FAM104A_ENST00000583024.1_Intron|FAM104A_ENST00000580032.1_5'UTR|FAM104A_ENST00000583178.1_5'UTR	NM_001098832.1	NP_001092302.1	Q969W3	F104A_HUMAN	family with sequence similarity 104, member A	90										endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6			LUSC - Lung squamous cell carcinoma(166;0.197)			TCTTTTGGTCTGGGGGGGAAGA	0.416													9	464	---	---	---	---					
TLE2	7089	broad.mit.edu	37	19	3028803	3028804	+	Splice_Site	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:3028803_3028804insG	ENST00000262953.6	-	2	287		c.e2-2		TLE2_ENST00000443826.3_Splice_Site|TLE2_ENST00000426948.2_Splice_Site|TLE2_ENST00000591529.1_Splice_Site|TLE2_ENST00000455444.2_5'UTR|TLE2_ENST00000590536.1_Splice_Site	NM_003260.4	NP_003251.2	Q04725	TLE2_HUMAN	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)						negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	13				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGCGGGGTCTGGGGGGGGTGT	0.624													7	50	---	---	---	---					
FBN3	84467	broad.mit.edu	37	19	8196624	8196625	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:8196624_8196625insC	ENST00000600128.1	-	15	2217_2218	c.1803_1804insG	c.(1801-1806)ggtggcfs	p.G602fs	FBN3_ENST00000601739.1_Frame_Shift_Ins_p.G602fs|FBN3_ENST00000270509.2_Frame_Shift_Ins_p.G602fs			Q75N90	FBN3_HUMAN	fibrillin 3	602	EGF-like 7; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						CCTACCGCCAGCCCCCCCAGGC	0.678													9	80	---	---	---	---					
MUC16	94025	broad.mit.edu	37	19	9064309	9064310	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:9064309_9064310insG	ENST00000397910.4	-	3	23339_23340	c.23136_23137insC	c.(23134-23139)ccctccfs	p.S7713fs		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7715	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGAAGGGGAGAGGGGGGGATAT	0.530													16	423	---	---	---	---					
ANGPTL6	83854	broad.mit.edu	37	19	10204185	10204186	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:10204185_10204186insC	ENST00000253109.4	-	5	1299_1300	c.1061_1062insG	c.(1060-1062)gcgfs	p.A354fs	ANGPTL6_ENST00000589181.1_Frame_Shift_Ins_p.A314fs|ANGPTL6_ENST00000592641.1_Frame_Shift_Ins_p.A354fs	NM_031917.2	NP_114123.2	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6	354	Fibrinogen C-terminal.				angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)	12			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			GTGCTCCACGGCCCCCCCAGTC	0.639													10	73	---	---	---	---					
DNMT1	1786	broad.mit.edu	37	19	10291083	10291084	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:10291083_10291084insG	ENST00000340748.4	-	4	622_623	c.387_388insC	c.(385-390)ccaaccfs	p.T130fs	DNMT1_ENST00000359526.4_Frame_Shift_Ins_p.T130fs|DNMT1_ENST00000540357.1_Frame_Shift_Ins_p.T130fs			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	130	Interaction with DNMT3A.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	GAAAGGGGTTTGGGGGGGCTGT	0.495													14	267	---	---	---	---					
ZNF878	729747	broad.mit.edu	37	19	12155708	12155709	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:12155708_12155709insT	ENST00000602107.1	-	5	647_648	c.648_649insA	c.(646-651)aacctafs	p.NL216fs	CTD-2006C1.2_ENST00000476474.1_RNA|CTD-2006C1.10_ENST00000547473.1_Intron|ZNF878_ENST00000547628.1_Frame_Shift_Ins_p.NL169fs|CTD-2006C1.2_ENST00000591838.1_RNA|CTD-2006C1.2_ENST00000591898.1_RNA			C9JN71	ZN878_HUMAN	zinc finger protein 878	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						CATTCATAGGGTTTTTTTGCAG	0.411													13	604	---	---	---	---					
CIB3	117286	broad.mit.edu	37	19	16275653	16275654	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:16275653_16275654insC	ENST00000269878.4	-	5	466_467	c.417_418insG	c.(415-420)ggtgagfs	p.E140fs	CIB3_ENST00000379859.3_Frame_Shift_Ins_p.E91fs|CIB3_ENST00000541493.1_5'UTR	NM_054113.2	NP_473454.1	Q96Q77	CIB3_HUMAN	calcium and integrin binding family member 3	140							calcium ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	16						TCGGCACTCAGCCCCCCCCGCG	0.564													17	278	---	---	---	---					
TSHZ3	57616	broad.mit.edu	37	19	31769141	31769142	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:31769141_31769142insC	ENST00000240587.4	-	2	1884_1885	c.1557_1558insG	c.(1555-1560)ggttgafs	p.*520fs		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	520					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					AGGATATCAAGCCCCCCCTTGG	0.500													14	471	---	---	---	---					
FBL	2091	broad.mit.edu	37	19	40325192	40325193	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:40325192_40325193insG	ENST00000221801.3	-	9	1064_1065	c.951_952insC	c.(949-954)ccaggtfs	p.G318fs	FBL_ENST00000593503.1_5'UTR	NM_001436.3	NP_001427.2	P22087	FBRL_HUMAN	fibrillarin	318					rRNA processing|tRNA processing	box C/D snoRNP complex|Cajal body	methyltransferase activity|protein binding|RNA binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)	9	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)		TTCTTCACCTTGGGGGGTGGCC	0.505													9	488	---	---	---	---					
CEACAM5	1048	broad.mit.edu	37	19	42224865	42224866	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:42224865_42224866insC	ENST00000221992.6	+	8	1909_1910	c.1795_1796insC	c.(1795-1797)cccfs	p.P599fs	CEACAM5_ENST00000405816.1_Frame_Shift_Ins_p.P599fs|CEACAM5_ENST00000398599.4_Frame_Shift_Ins_p.P598fs|CEA_ENST00000598976.1_Intron	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	599	Ig-like 7.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		CCCCATCATTTCCCCCCCAGAC	0.545													7	310	---	---	---	---					
PSG7	5676	broad.mit.edu	37	19	43439519	43439520	+	RNA	INS	-	-	C	rs59911953	by1000genomes	TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:43439519_43439520insC	ENST00000406070.2	-	0	527				PSG7_ENST00000446844.3_RNA	NM_002783.2	NP_002774.2	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				AATGACCCCTGCCCCCCAACAC	0.515													11	822	---	---	---	---					
KCNN4	3783	broad.mit.edu	37	19	44273714	44273715	+	Splice_Site	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:44273714_44273715insG	ENST00000262888.3	-	6	1326		c.e6-2			NM_002250.2	NP_002241.1	O15554	KCNN4_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4						defense response	voltage-gated potassium channel complex	calcium-activated potassium channel activity|calmodulin binding			biliary_tract(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0352)			Clotrimazole(DB00257)|Halothane(DB01159)|Quinine(DB00468)	CTCCTTCATCTGGGGGTGGGTG	0.604													8	696	---	---	---	---					
CLASRP	11129	broad.mit.edu	37	19	45556128	45556129	+	Frame_Shift_Ins	INS	-	-	C	rs146240710		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:45556128_45556129insC	ENST00000544944.2	+	3	969_970	c.277_278insC	c.(277-279)cccfs	p.P93fs	CLASRP_ENST00000221455.3_Frame_Shift_Ins_p.P93fs|CLASRP_ENST00000391953.4_Intron			Q8N2M8	CLASR_HUMAN	CLK4-associating serine/arginine rich protein	93					mRNA processing|RNA splicing	nucleus		p.L96fs*17(1)		breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|pancreas(2)|prostate(1)	16						CCCCGACTACACCCCCCCTCTG	0.614													10	215	---	---	---	---					
SNRNP70	6625	broad.mit.edu	37	19	49589711	49589712	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:49589711_49589712insC	ENST00000221448.5	+	2	236_237	c.40_41insC	c.(40-42)cccfs	p.P14fs	SNRNP70_ENST00000598441.1_Frame_Shift_Ins_p.P14fs	NM_003089.4	NP_003080.2	P08621	RU17_HUMAN	small nuclear ribonucleoprotein 70kDa (U1)	14					nuclear mRNA splicing, via spliceosome|regulation of RNA splicing	nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding	p.R16fs*2(1)		cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|skin(2)	12						GGCCCTCTTTGCCCCCCGTGAC	0.540													10	529	---	---	---	---					
HRC	3270	broad.mit.edu	37	19	49657097	49657098	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:49657097_49657098insG	ENST00000252825.4	-	1	1583_1584	c.1397_1398insC	c.(1396-1398)cggfs	p.R466fs	HRC_ENST00000595625.1_Frame_Shift_Ins_p.R466fs	NM_002152.2	NP_002143.1	P23327	SRCH_HUMAN	histidine rich calcium binding protein	466					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(10)|lung(10)|ovary(1)|prostate(3)|urinary_tract(2)	34		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		CTGTGTGTCCTGGGGGGTGATG	0.550													7	510	---	---	---	---					
TSKS	60385	broad.mit.edu	37	19	50243063	50243064	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:50243063_50243064insG	ENST00000246801.3	-	11	1830_1831	c.1748_1749insC	c.(1747-1749)caafs	p.Q583fs	TSKS_ENST00000358830.3_Frame_Shift_Ins_p.Q383fs	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	583							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CCCCCTGTTTTGGGGGGGTTCC	0.545													15	474	---	---	---	---					
GPR32	2854	broad.mit.edu	37	19	51274914	51274915	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:51274914_51274915insC	ENST00000270590.4	+	1	1194_1195	c.1057_1058insC	c.(1057-1059)cccfs	p.P353fs		NM_001506.1	NP_001497.1	O75388	GPR32_HUMAN	G protein-coupled receptor 32	353						integral to plasma membrane	N-formyl peptide receptor activity			breast(4)|endometrium(4)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	29		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CCGTGGCAACGCCCCCCGGGAA	0.525													7	230	---	---	---	---					
KLK1	3816	broad.mit.edu	37	19	51326962	51326963	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:51326962_51326963insC	ENST00000301420.2	-	1	77_78	c.42_43insG	c.(40-45)ggctggfs	p.W15fs	KLK1_ENST00000448701.2_5'UTR	NM_002257.2	NP_002248.1	P06870	KLK1_HUMAN	kallikrein 1	15					proteolysis	nucleus	serine-type endopeptidase activity			breast(1)|large_intestine(4)|lung(7)|urinary_tract(1)	13		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00399)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCTCACCAGTCCCCCCCAGGG	0.653													20	345	---	---	---	---					
ZNF649	65251	broad.mit.edu	37	19	52394013	52394014	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:52394013_52394014insC	ENST00000354957.3	-	5	1659_1660	c.1375_1376insG	c.(1375-1377)ttcfs	p.F459fs	CTC-429C10.2_ENST00000600329.1_RNA|ZNF649_ENST00000600738.1_Frame_Shift_Ins_p.F431fs	NM_023074.3	NP_075562.2	Q9BS31	ZN649_HUMAN	zinc finger protein 649	459					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		CTTCACTGAATCCCCCCGTTTC	0.450													9	938	---	---	---	---					
CNOT3	4849	broad.mit.edu	37	19	54649666	54649667	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr19:54649666_54649667insC	ENST00000406403.1	+	8	2327_2328	c.724_725insC	c.(724-726)cccfs	p.P242fs	CNOT3_ENST00000358389.3_Frame_Shift_Ins_p.P61fs|CNOT3_ENST00000221232.5_Frame_Shift_Ins_p.P242fs			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	242					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GGTCGCCACCTCCCCTCCCAGC	0.644													8	126	---	---	---	---					
NRSN2	80023	broad.mit.edu	37	20	333922	333923	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr20:333922_333923insC	ENST00000382291.3	+	4	498_499	c.258_259insC	c.(256-261)gtccccfs	p.VP86fs	NRSN2_ENST00000492242.1_3'UTR|NRSN2_ENST00000382285.2_Frame_Shift_Ins_p.VP86fs	NM_024958.2	NP_079234.1	Q9GZP1	NRSN2_HUMAN	neurensin 2	86						integral to membrane|plasma membrane|transport vesicle				endometrium(1)|large_intestine(2)|lung(4)|urinary_tract(1)	8		all_cancers(10;0.0834)				GCTATGCAGTGCCCCCCAAGCT	0.644													8	528	---	---	---	---					
FASTKD5	60493	broad.mit.edu	37	20	3128000	3128001	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr20:3128000_3128001insC	ENST00000380266.3	-	2	2037_2038	c.1716_1717insG	c.(1714-1719)ggcccafs	p.GP572fs	UBOX5_ENST00000217173.2_Intron|UBOX5-AS1_ENST00000446537.1_RNA|UBOX5_ENST00000348031.2_Intron	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	572					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						ACGTACTGGGGCCCCCCCAGCA	0.436													11	214	---	---	---	---					
TM9SF4	9777	broad.mit.edu	37	20	30737490	30737491	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr20:30737490_30737491insC	ENST00000217315.5	+	10	1297_1298	c.957_958insC	c.(955-960)agccccfs	p.SP319fs	TM9SF4_ENST00000398022.2_Frame_Shift_Ins_p.SP336fs			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	336						integral to membrane				central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			ACGTCTTCAGGCCCCCCCAGTA	0.604													9	162	---	---	---	---					
PLAGL2	5326	broad.mit.edu	37	20	30789951	30789952	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr20:30789951_30789952insG	ENST00000246229.4	-	2	294_295	c.30_31insC	c.(28-33)ccggatfs	p.D11fs		NM_002657.3	NP_002648.1	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	11						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|liver(1)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TCTTGAATCCAGGGGGGGACGC	0.559													10	285	---	---	---	---					
RALGAPB	57148	broad.mit.edu	37	20	37146232	37146233	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr20:37146232_37146233insC	ENST00000262879.6	+	8	1419_1420	c.1135_1136insC	c.(1135-1137)cccfs	p.P379fs	RALGAPB_ENST00000537204.1_Frame_Shift_Ins_p.P379fs|RALGAPB_ENST00000397038.1_Frame_Shift_Ins_p.P157fs|RALGAPB_ENST00000397040.1_Frame_Shift_Ins_p.P379fs|RALGAPB_ENST00000397042.3_Frame_Shift_Ins_p.P379fs			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	379					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity	p.H382fs*2(1)		breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TGTCAGTACCACCCCCCCACAT	0.446													10	257	---	---	---	---					
LPIN3	64900	broad.mit.edu	37	20	39977298	39977299	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr20:39977298_39977299insG	ENST00000373257.3	+	4	419_420	c.328_329insG	c.(328-330)gggfs	p.G110fs		NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	110					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				ACCCATCCCTTGGGGGGGTCTG	0.663													8	126	---	---	---	---					
MYBL2	4605	broad.mit.edu	37	20	42344628	42344629	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr20:42344628_42344629insG	ENST00000217026.4	+	14	2131_2132	c.2004_2005insG	c.(2002-2007)tgggggfs	p.WG668fs	MYBL2_ENST00000396863.4_Frame_Shift_Ins_p.WG644fs	NM_002466.2	NP_002457.1	P10244	MYBB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 2	668						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.G669W(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	46		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CGGTGGCCTGCGGGGGGACCAG	0.624													10	507	---	---	---	---					
SLPI	6590	broad.mit.edu	37	20	43881730	43881731	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr20:43881730_43881731insG	ENST00000338380.2	-	3	326_327	c.306_307insC	c.(304-309)ccatttfs	p.F103fs		NM_003064.2	NP_003055.1	P03973	SLPI_HUMAN	secretory leukocyte peptidase inhibitor	103	Elastase inhibitory domain.|WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity			lung(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				TCACAGAAATTGGGGGGGTTAA	0.535													24	512	---	---	---	---					
SLC12A5	57468	broad.mit.edu	37	20	44680421	44680422	+	Frame_Shift_Ins	INS	-	-	G	rs138144890		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr20:44680421_44680422insG	ENST00000454036.1	+	18	2434_2435	c.2358_2359insG	c.(2356-2361)ctggggfs	p.LG786fs	SLC12A5_ENST00000243964.3_Frame_Shift_Ins_p.LG763fs	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	786					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CCGGGGGCCTCGGGGGGCTGCA	0.599													7	455	---	---	---	---					
OSBPL2	9885	broad.mit.edu	37	20	60854257	60854258	+	Frame_Shift_Ins	INS	-	-	C	rs79735057		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr20:60854257_60854258insC	ENST00000313733.3	+	7	738_739	c.536_537insC	c.(535-537)cccfs	p.P179fs	OSBPL2_ENST00000358053.2_Frame_Shift_Ins_p.P167fs|OSBPL2_ENST00000439951.2_Frame_Shift_Ins_p.P87fs	NM_144498.1	NP_653081.1	Q9H1P3	OSBL2_HUMAN	oxysterol binding protein-like 2	179					lipid transport		lipid binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			GTCAGTCACCACCCCCCCATCA	0.465													15	264	---	---	---	---					
P2RX6P	440799	broad.mit.edu	37	22	21399220	21399221	+	RNA	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr22:21399220_21399221insC	ENST00000439119.1	-	0	51					NR_002829.1																						TCTGCAGGGCGCCCCCCCACCA	0.599													11	171	---	---	---	---					
BMS1P20	96610	broad.mit.edu	37	22	22661173	22661174	+	RNA	INS	-	-	C	rs7410785		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr22:22661173_22661174insC	ENST00000426066.1	+	0	265_266					NR_027293.1																						ATACAGGTTTTCCCCCCCCACC	0.406													13	105	---	---	---	---					
DDX17	10521	broad.mit.edu	37	22	38895454	38895455	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr22:38895454_38895455insC	ENST00000396821.3	-	3	587_588	c.488_489insG	c.(487-489)ggafs	p.G163fs	DDX17_ENST00000381633.3_Frame_Shift_Ins_p.G84fs|DDX17_ENST00000432525.1_5'UTR	NM_001098504.1|NM_006386.4	NP_001091974.1|NP_006377.2	Q92841	DDX17_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 17	84	Helicase ATP-binding.				RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity	p.G163fs*20(1)		breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(6)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	25	Melanoma(58;0.0286)					GACAAACATCTCCCCCCCTCAC	0.381													13	207	---	---	---	---					
SREBF2	6721	broad.mit.edu	37	22	42271636	42271637	+	Frame_Shift_Ins	INS	-	-	C	rs79727196		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr22:42271636_42271637insC	ENST00000361204.4	+	7	1460_1461	c.1294_1295insC	c.(1294-1296)cccfs	p.P432fs		NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	432	Interaction with LMNA (By similarity).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						CCTTCTGATGTCCCCCCCAGCC	0.520													7	224	---	---	---	---					
SSX3	10214	broad.mit.edu	37	X	48209462	48209463	+	Frame_Shift_Ins	INS	-	-	G	rs6651589	byFrequency	TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chrX:48209462_48209463insG	ENST00000298396.2	-	6	477_478	c.425_426insC	c.(424-426)cggfs	p.R142fs	SSX3_ENST00000376895.1_Frame_Shift_Ins_p.R54fs|SSX3_ENST00000376893.3_Frame_Shift_Ins_p.R142fs	NM_021014.2	NP_066294.1	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3	142					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding	p.P142Q(2)		endometrium(3)|large_intestine(1)|lung(9)	13						TTGGTTTTCCCGGGGGGCACAG	0.495													8	564	---	---	---	---					
KIAA2022	340533	broad.mit.edu	37	X	73963268	73963269	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chrX:73963268_73963269insC	ENST00000373468.1	-	3	1774_1775	c.1123_1124insG	c.(1123-1125)ggafs	p.G375fs	KIAA2022_ENST00000055682.5_Frame_Shift_Ins_p.G375fs			Q5QGS0	K2022_HUMAN	KIAA2022	375					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TTTATCTTCCTCCCCCCAGATG	0.475													11	612	---	---	---	---					
COL4A5	1287	broad.mit.edu	37	X	107834821	107834822	+	Frame_Shift_Ins	INS	-	-	C	rs104886321		TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chrX:107834821_107834822insC	ENST00000328300.6	+	21	1614_1615	c.1370_1371insC	c.(1369-1371)gccfs	p.A457fs	COL4A5_ENST00000361603.2_Frame_Shift_Ins_p.A457fs	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	457	Triple-helical region.		Missing (in APSX).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						GGCCCTCCAGGCCCCCCAGGAT	0.406									Alport syndrome with Diffuse Leiomyomatosis				11	615	---	---	---	---					
TENM1	10178	broad.mit.edu	37	X	123514784	123514785	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chrX:123514784_123514785insC	ENST00000422452.2	-	32	7863_7864	c.7800_7801insG	c.(7798-7803)ggggcgfs	p.A2601fs	STAG2_ENST00000469481.1_Intron|TENM1_ENST00000371130.3_Frame_Shift_Ins_p.A2594fs	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1									p.R2596fs*15(1)									AGAATCCGCCTCCCCCCAGTGT	0.500													7	293	---	---	---	---					
PLAC1	10761	broad.mit.edu	37	X	133700357	133700358	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chrX:133700357_133700358insG	ENST00000359237.4	-	3	640_641	c.355_356insC	c.(355-357)aaafs	p.K119fs	PLAC1_ENST00000476971.1_5'UTR	NM_021796.3	NP_068568.1	Q9HBJ0	PLAC1_HUMAN	placenta-specific 1	119					placenta development	extracellular region				large_intestine(4)|lung(1)|pancreas(1)	6	Acute lymphoblastic leukemia(192;0.000127)					TGGGGACTTTTGGGGGGCAGCA	0.530													10	269	---	---	---	---					
GPR112	139378	broad.mit.edu	37	X	135426885	135426886	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chrX:135426885_135426886insA	ENST00000394143.1	+	6	1311_1312	c.1020_1021insA	c.(1018-1023)ataaaafs	p.IK340fs	GPR112_ENST00000412101.1_Frame_Shift_Ins_p.IK135fs|GPR112_ENST00000394141.1_Frame_Shift_Ins_p.IK135fs|GPR112_ENST00000370652.1_Frame_Shift_Ins_p.IK340fs|GPR112_ENST00000287534.4_Frame_Shift_Ins_p.IK277fs	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	340					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CCAATTCCATGAAAAAAACGAA	0.386													8	757	---	---	---	---					
GPR112	139378	broad.mit.edu	37	X	135455155	135455156	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chrX:135455155_135455156insG	ENST00000394143.1	+	15	7999_8000	c.7708_7709insG	c.(7708-7710)gggfs	p.G2570fs	GPR112_ENST00000412101.1_Frame_Shift_Ins_p.G2365fs|GPR112_ENST00000394141.1_Frame_Shift_Ins_p.G2365fs|GPR112_ENST00000370652.1_Frame_Shift_Ins_p.G2570fs|GPR112_ENST00000287534.4_Frame_Shift_Ins_p.G2368fs	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2570					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.R2570L(1)		NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					GGCTGTGCTGCGGGGGGACCAC	0.530													21	1627	---	---	---	---					
FGF13	2258	broad.mit.edu	37	X	137939822	137939823	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chrX:137939822_137939823insG	ENST00000370603.3	-	2	67_68	c.68_69insC	c.(67-69)cggfs	p.R23fs	FGF13_ENST00000541469.1_Intron|FGF13_ENST00000441825.2_5'UTR			Q92913	FGF13_HUMAN	fibroblast growth factor 13	0					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	24	Acute lymphoblastic leukemia(192;0.000127)					CCTGTGTGCCAGGGGGGGCGTC	0.431													8	144	---	---	---	---					
DKC1	1736	broad.mit.edu	37	X	153994193	153994193	+	Frame_Shift_Del	DEL	G	G	-			TCGA-AK-3453-01A-01W-0886-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d57003b-ee54-45d9-b00b-fdb007421d93	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chrX:153994193delG	ENST00000369550.5	+	4	393	c.183delG	c.(181-183)aafs	p.K61fs		NM_001142463.1|NM_001363.3	NP_001135935.1|NP_001354.1	O60832	DKC1_HUMAN	dyskeratosis congenita 1, dyskerin	61					cell proliferation|pseudouridine synthesis|rRNA processing|telomere maintenance via telomerase	Cajal body|nucleolus|telomerase holoenzyme complex	protein binding|pseudouridine synthase activity|RNA binding|telomerase activity			breast(2)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)	15	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ATTTTGATAAGCTGAATGTAA	0.413									Congenital Dyskeratosis				9	194	---	---	---	---					
IRF2BP2	359948	broad.mit.edu	37	1	234743195	234743197	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr1:234743195_234743197delTCC	ENST00000366609.3	-	2	1480_1482	c.1450_1452delGGA	c.(1450-1452)del	p.G484del	IRF2BP2_ENST00000491430.1_5'UTR|RP4-781K5.2_ENST00000436039.1_RNA|IRF2BP2_ENST00000366610.3_In_Frame_Del_p.G468del	NM_182972.2	NP_892017.2	Q7Z5L9	I2BP2_HUMAN	interferon regulatory factor 2 binding protein 2	484					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	11	Ovarian(103;0.0303)	all_cancers(173;0.0236)|Prostate(94;0.0115)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)|Epithelial(3;6.2e-05)			CTGGCTCCAGTCCTCCTGTGTTG	0.645													9	166	---	---	---	---					
ARRDC3	57561	broad.mit.edu	37	5	90667241	90667243	+	In_Frame_Del	DEL	ATC	ATC	-			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr5:90667241_90667243delATC	ENST00000265138.3	-	8	1485_1487	c.1219_1221delGAT	c.(1219-1221)del	p.D407del		NM_020801.2	NP_065852.1	Q96B67	ARRD3_HUMAN	arrestin domain containing 3	407					signal transduction	cytoplasm	protein binding			breast(2)|endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	18		all_cancers(142;2.22e-05)|all_epithelial(76;1.58e-07)|all_lung(232;0.000521)|Lung NSC(167;0.000548)|Ovarian(174;0.0798)|Colorectal(57;0.207)		OV - Ovarian serous cystadenocarcinoma(54;4.56e-30)|Epithelial(54;7.55e-26)|all cancers(79;3.63e-22)		AGGATGGTCTATCATCTGCTGAC	0.414													10	89	---	---	---	---					
HLA-DRB6	3128	broad.mit.edu	37	6	32521843	32521844	+	RNA	DEL	CT	CT	-	rs67101368		TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:32521843_32521844delCT	ENST00000411500.1	-	0	740					NR_001298.1																						AGAAGGCTACCTCCTGTAAGAA	0.356													4	5	---	---	---	---					
CYB5R4	51167	broad.mit.edu	37	6	84569562	84569562	+	Frame_Shift_Del	DEL	G	G	-			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr6:84569562delG	ENST00000369681.4	+	1	201	c.61delG	c.(61-63)ggfs	p.G22fs	CYB5R4_ENST00000369679.4_5'UTR	NM_016230.3	NP_057314.2	Q7L1T6	NB5R4_HUMAN	cytochrome b5 reductase 4	22					cell development|detection of oxygen|generation of precursor metabolites and energy|glucose homeostasis|insulin secretion|response to antibiotic|superoxide metabolic process	endoplasmic reticulum|perinuclear region of cytoplasm	cytochrome-b5 reductase activity|heme binding|NAD(P)H oxidase activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	23		all_cancers(76;7e-07)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00128)		BRCA - Breast invasive adenocarcinoma(397;0.0871)		TGTCGCCTCCGGGGGGCGTAG	0.677											OREG0017553	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	24	---	---	---	---					
DAOA-AS1	282706	broad.mit.edu	37	13	106148111	106148114	+	RNA	DEL	CTTC	CTTC	-			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr13:106148111_106148114delCTTC	ENST00000448407.1	-	0	100					NR_040247.1																						GGATCTTTCTcttccttccttcct	0.353													4	9	---	---	---	---					
MIEN1	84299	broad.mit.edu	37	17	37885932	37885935	+	Frame_Shift_Del	DEL	ACTC	ACTC	-			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:37885932_37885935delACTC	ENST00000577810.1	-	3	281_284	c.267_270delGAGT	c.(265-270)gtfs	p.VS89fs	MIEN1_ENST00000474210.1_Intron|ERBB2_ENST00000584888.1_Intron|MIEN1_ENST00000394231.3_Intron	NM_032339.3	NP_115715.3	Q9BRT3	CQ037_HUMAN	migration and invasion enhancer 1	89					cell redox homeostasis	cytosol|membrane	selenium binding										CGCTGTAAATACTCACATCTTTCT	0.485													22	562	---	---	---	---					
LINC00854	100874261	broad.mit.edu	37	17	41381913	41381914	+	RNA	INS	-	-	T	rs11403368		TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chr17:41381913_41381914insT	ENST00000433702.2	-	0	14					NR_047479.1																						accctgatctatcatcgggagg	0.550													5	6	---	---	---	---					
DKC1	1736	broad.mit.edu	37	X	153994193	153994193	+	Frame_Shift_Del	DEL	G	G	-			TCGA-AK-3453-01A-01D-0966-08	TCGA-AK-3453-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9926cc0-ce09-449c-a96e-082be656a1d7	c5f57cc9-32dc-41f5-b43e-8999e241adc4	g.chrX:153994193delG	ENST00000369550.5	+	4	393	c.183delG	c.(181-183)aafs	p.K61fs		NM_001142463.1|NM_001363.3	NP_001135935.1|NP_001354.1	O60832	DKC1_HUMAN	dyskeratosis congenita 1, dyskerin	61					cell proliferation|pseudouridine synthesis|rRNA processing|telomere maintenance via telomerase	Cajal body|nucleolus|telomerase holoenzyme complex	protein binding|pseudouridine synthase activity|RNA binding|telomerase activity			breast(2)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)	15	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ATTTTGATAAGCTGAATGTAA	0.413									Congenital Dyskeratosis				7	223	---	---	---	---					
