Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GAB3	139716	broad.mit.edu	37	X	153927719	153927719	+	Missense_Mutation	SNP	G	G	A			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chrX:153927719G>A	ENST00000369575.3	-	6	1223	c.1192C>T	c.(1192-1194)Ccc>Tcc	p.P398S	GAB3_ENST00000496390.1_5'UTR|GAB3_ENST00000424127.2_Missense_Mutation_p.P399S	NM_001081573.1|NM_080612.2	NP_001075042.1|NP_542179.1	Q8WWW8	GAB3_HUMAN	GRB2-associated binding protein 3	398										NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)	25	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CCAGCCTGGGGGCTCATGGGC	0.552000													5	68					0	0	0.184627	0	0
NPIPA5	100288332	broad.mit.edu	37	16	15457701	15457701	+	Missense_Mutation	SNP	G	G	A			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr16:15457701G>A	ENST00000360151.4	-	8	867	c.868C>T	c.(868-870)Ctc>Ttc	p.L290F		NM_001277325.1	NP_001264254.1			nuclear pore complex interacting protein family, member A5									p.L290F(2)									AGGGGAGTGAGCAGACACTCG	0.562000													4	84					0	0	0.184627	0	0
TAC1	6863	broad.mit.edu	37	7	97363056	97363056	+	Missense_Mutation	SNP	G	G	C			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr7:97363056G>C	ENST00000319273.5	+	3	442	c.145G>C	c.(145-147)Gag>Cag	p.E49Q	TAC1_ENST00000346867.4_Missense_Mutation_p.E49Q|TAC1_ENST00000350485.4_Missense_Mutation_p.E49Q	NM_003182.2	NP_003173.1	P20366	TKN1_HUMAN	tachykinin, precursor 1	49					detection of abiotic stimulus|elevation of cytosolic calcium ion concentration|insemination|neuropeptide signaling pathway|synaptic transmission|tachykinin receptor signaling pathway	extracellular space				large_intestine(4)|lung(6)|urinary_tract(1)	11	all_cancers(62;3.95e-09)|all_epithelial(64;1.1e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0358)|all_lung(186;0.0384)				Bacitracin(DB00626)	GGAGCCCTTTGAGCATCTTCT	0.597000													12	70					0	0	0.411799	0	0
CHST2	9435	broad.mit.edu	37	3	142840289	142840289	+	Missense_Mutation	SNP	T	T	G			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr3:142840289T>G	ENST00000309575.3	+	2	2015	c.631T>G	c.(631-633)Tcc>Gcc	p.S211A		NM_004267.4	NP_004258.2	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2	211					inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(2)	22						GGACGCCGTTTCCCTGCAGGG	0.602000													14	123					0	0	0.457914	0	0
OR6C75	390323	broad.mit.edu	37	12	55759683	55759683	+	Silent	SNP	A	A	G			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr12:55759683A>G	ENST00000343399.3	+	1	789	c.789A>G	c.(787-789)agA>agG	p.R263R		NM_001005497.1	NP_001005497.1	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C, member 75	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)	25						CTTCTGCCAGAGAAAGGGTGA	0.423000													10	91					0	0	0.411799	0	0
LOC645752	645752	broad.mit.edu	37	15	78217315	78217315	+	RNA	SNP	T	T	C	rs2004373	by1000genomes	TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr15:78217315T>C	ENST00000567226.1	-	0	187																											AGTGGTTGTCTCAGGGCTACT	0.527000													3	69					0	0	0.115264	0	0
RASGEF1B	153020	broad.mit.edu	37	4	82355860	82355860	+	Missense_Mutation	SNP	A	A	C			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr4:82355860A>C	ENST00000509081.1	-	11	1351	c.1130T>G	c.(1129-1131)aTc>aGc	p.I377S	RASGEF1B_ENST00000264400.2_Missense_Mutation_p.I378S|RASGEF1B_ENST00000335927.7_Missense_Mutation_p.I336S			Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	378	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			endometrium(2)|kidney(5)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	26						AATATCTTTGATTAAGAGACT	0.363000													3	25					0	0	0.115264	0	0
OR8K1	390157	broad.mit.edu	37	11	56113847	56113847	+	Missense_Mutation	SNP	G	G	T			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr11:56113847G>T	ENST00000279783.2	+	1	427	c.333G>T	c.(331-333)gaG>gaT	p.E111D		NM_001002907.1	NP_001002907.1	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K, member 1	111					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(8)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Esophageal squamous(21;0.00448)					CATTCTTTGAGATTTTCATCA	0.408000										HNSCC(65;0.19)			32	279					1.36615e-20	1.90285e-20	0.769981	1	0
CDH5	1003	broad.mit.edu	37	16	66420782	66420782	+	Missense_Mutation	SNP	G	G	T			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr16:66420782G>T	ENST00000341529.3	+	3	429	c.281G>T	c.(280-282)cGg>cTg	p.R94L	CDH5_ENST00000563425.2_Missense_Mutation_p.R94L	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	94	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		AAGGTCTTCCGGGTCGATGCA	0.517000													3	40					0.115264	0.124869	0.115264	1	0
OR2T6	254879	broad.mit.edu	37	1	248551308	248551308	+	Silent	SNP	T	T	C			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr1:248551308T>C	ENST00000355728.2	+	1	399	c.399T>C	c.(397-399)ccT>ccC	p.P133P		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	133					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGCGCTATCCTGTCCTCATCA	0.567000													5	70					0	0	0.184627	0	0
CMTR2	55783	broad.mit.edu	37	16	71318686	71318686	+	Missense_Mutation	SNP	G	G	A			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr16:71318686G>A	ENST00000338099.5	-	3	1474	c.1138C>T	c.(1138-1140)Cgt>Tgt	p.R380C	FTSJD1_ENST00000434935.2_Missense_Mutation_p.R380C			Q8IYT2	FTSJ1_HUMAN		380						integral to membrane	methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TCAAATAGACGAATGTTTTCA	0.328000													6	43					0	0	0.217242	0	0
LINC00969	440993	broad.mit.edu	37	3	195395402	195395402	+	RNA	SNP	C	C	A	rs149044725	by1000genomes	TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr3:195395402C>A	ENST00000445430.1	+	0	809																											TACGGGCGCACCTACTTGAGC	0.597000													5	42					0.00621372	0.0071275	0.335167	1	0
EEF1A1	1915	broad.mit.edu	37	6	74228192	74228192	+	Missense_Mutation	SNP	C	C	A			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr6:74228192C>A	ENST00000316292.9	-	5	1905	c.914G>T	c.(913-915)gGg>gTg	p.G305V	EEF1A1_ENST00000309268.6_Missense_Mutation_p.G305V|EEF1A1_ENST00000491404.1_Intron|EEF1A1_ENST00000331523.2_Missense_Mutation_p.G305V	NM_001402.5	NP_001393.1	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha 1	305						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(6)|prostate(2)|skin(3)	18						CACATTGTCCCCAGGAAGAGC	0.483000											OREG0003895	type=REGULATORY REGION|Gene=D16891|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	4	59					0.00198382	0.00234451	0.248553	1	0
VWF	7450	broad.mit.edu	37	12	6161870	6161870	+	Silent	SNP	C	C	T			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr12:6161870C>T	ENST00000261405.5	-	16	2279	c.2025G>A	c.(2023-2025)ccG>ccA	p.P675P		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	675	TIL 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	ATTCCTCATCCGGGTAAGAGA	0.622000													5	43					0	0	0.217242	0	0
GPR17	2840	broad.mit.edu	37	2	128408751	128408751	+	Missense_Mutation	SNP	G	G	A			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr2:128408751G>A	ENST00000544369.1	+	4	1137	c.526G>A	c.(526-528)Gca>Aca	p.A176T	GPR17_ENST00000486700.1_3'UTR|GPR17_ENST00000272644.3_Missense_Mutation_p.A176T|LIMS2_ENST00000410011.1_Intron|LIMS2_ENST00000545738.2_Intron|LIMS2_ENST00000324938.5_Intron|LIMS2_ENST00000409455.1_Intron|LIMS2_ENST00000355119.4_Intron|GPR17_ENST00000393018.3_Missense_Mutation_p.A176T|LIMS2_ENST00000409808.2_Intron	NM_001161415.1	NP_001154887.1	Q13304	GPR17_HUMAN	G protein-coupled receptor 17	176						integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|prostate(2)|urinary_tract(1)	19	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		GCCCCTCTACGCACACCTGGC	0.642000													13	124					0	0	0.457914	0	0
GPR149	344758	broad.mit.edu	37	3	154056047	154056047	+	Missense_Mutation	SNP	G	G	A			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr3:154056047G>A	ENST00000389740.2	-	4	1736	c.1637C>T	c.(1636-1638)gCc>gTc	p.A546V		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	546						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			AATGGCAAGGGCATAACCGGA	0.438000													5	170					0	0	0.184627	0	0
ELMO3	79767	broad.mit.edu	37	16	67237658	67237658	+	Missense_Mutation	SNP	A	A	T			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr16:67237658A>T	ENST00000393997.2	+	20	2257	c.2200A>T	c.(2200-2202)Atg>Ttg	p.M734L	ELMO3_ENST00000477898.1_Missense_Mutation_p.M568L|ELMO3_ENST00000360833.1_Missense_Mutation_p.M717L	NM_024712.3	NP_078988.2	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	681					apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding			cervix(2)|kidney(4)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	18		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		GCTGCTGACCATGGAGACCAA	0.642000													3	22					0	0	0.115264	0	0
TICAM1	148022	broad.mit.edu	37	19	4816506	4816506	+	Silent	SNP	C	C	A			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr19:4816506C>A	ENST00000248244.5	-	2	2113	c.1884G>T	c.(1882-1884)ccG>ccT	p.P628P		NM_182919.3	NP_891549.1	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	628	Pro-rich.|Sufficient to induce apoptosis.				apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GTGGCGGCTGCGGGCACCCCG	0.711000													5	22					0.0215528	0.0240159	0.217242	1	0
SNTG1	54212	broad.mit.edu	37	8	51569552	51569552	+	Missense_Mutation	SNP	G	G	T			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr8:51569552G>T	ENST00000522124.1	+	14	1594	c.933G>T	c.(931-933)agG>agT	p.R311S	SNTG1_ENST00000276467.5_Missense_Mutation_p.R311S|SNTG1_ENST00000518864.1_Missense_Mutation_p.R311S|SNTG1_ENST00000517473.1_Missense_Mutation_p.R311S	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	311	PH.				cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				TGGCCCTGAGGGGCTCATGTC	0.483000													9	88					3.86212e-05	5.19388e-05	0.361761	1	0
ABCA12	26154	broad.mit.edu	37	2	215820033	215820033	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr2:215820033C>A	ENST00000272895.7	-	43	6505	c.6286G>T	c.(6286-6288)Gga>Tga	p.G2096*	ABCA12_ENST00000389661.4_Nonsense_Mutation_p.G1778*|AC072062.1_ENST00000607412.1_RNA	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	2096					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AAGGCCATTCCTGTTTCATGG	0.418000													4	90					0.150653	0.158797	0.150653	1	0
TMEM190	147744	broad.mit.edu	37	19	55889522	55889522	+	Missense_Mutation	SNP	A	A	G			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr19:55889522A>G	ENST00000291934.3	+	5	503	c.485A>G	c.(484-486)gAa>gGa	p.E162G		NM_139172.1	NP_631911.1	Q8WZ59	TM190_HUMAN	transmembrane protein 190	162						integral to membrane				large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	5	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		accgagggggaagggacggag	0.637000													7	52					0	0	0.278610	0	0
ARNTL	406	broad.mit.edu	37	11	13387083	13387083	+	Silent	SNP	C	C	A			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr11:13387083C>A	ENST00000389708.3	+	10	851	c.496C>A	c.(496-498)Cga>Aga	p.R166R	ARNTL_ENST00000396441.3_Silent_p.R166R|ARNTL_ENST00000497429.1_3'UTR|ARNTL_ENST00000403290.1_Silent_p.R166R|ARNTL_ENST00000401424.1_Silent_p.R123R|ARNTL_ENST00000403482.3_Silent_p.R164R|ARNTL_ENST00000361003.4_Silent_p.R166R|ARNTL_ENST00000389707.4_Silent_p.R166R|ARNTL_ENST00000403510.3_Silent_p.R123R			O00327	BMAL1_HUMAN	aryl hydrocarbon receptor nuclear translocator-like	166	PAS 1.				circadian rhythm|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	aryl hydrocarbon receptor binding|DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|endometrium(2)|large_intestine(11)|lung(5)|upper_aerodigestive_tract(1)	20				Epithelial(150;0.0243)		AGGATGTGACCGAGGGAAGAT	0.433000													3	83					0.000602214	0.000757625	0.184627	1	0
SEPT2	4735	broad.mit.edu	37	2	242277165	242277165	+	Missense_Mutation	SNP	A	A	C			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr2:242277165A>C	ENST00000391973.2	+	7	1082	c.554A>C	c.(553-555)gAc>gCc	p.D185A	SEPT2_ENST00000407971.1_Missense_Mutation_p.D145A|SEPT2_ENST00000401990.1_Missense_Mutation_p.D195A|SEPT2_ENST00000360051.3_Missense_Mutation_p.D185A|SEPT2_ENST00000391971.2_Missense_Mutation_p.D185A|SEPT2_ENST00000402092.2_Missense_Mutation_p.D185A	NM_006155.1	NP_006146.1	Q15019	SEPT2_HUMAN	septin 2	185					cell division|mitosis	actin cytoskeleton|cleavage furrow|condensed chromosome kinetochore|midbody|nucleolus|septin complex|spindle	GTP binding			central_nervous_system(2)|endometrium(1)|large_intestine(4)|lung(3)|skin(2)	12		all_cancers(19;7.62e-41)|all_epithelial(40;1.71e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.24e-34)|all cancers(36;7.15e-32)|OV - Ovarian serous cystadenocarcinoma(60;1.21e-15)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;3.16e-06)|Lung(119;7.81e-05)|LUSC - Lung squamous cell carcinoma(224;0.000742)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0889)		GCAAAAGCTGACACTCTCACC	0.498000													6	85					0	0	0.278610	0	0
TM4SF20	79853	broad.mit.edu	37	2	228235653	228235653	+	Missense_Mutation	SNP	G	G	A	rs138005777		TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr2:228235653G>A	ENST00000304568.3	-	2	264	c.227C>T	c.(226-228)gCg>gTg	p.A76V		NM_024795.3	NP_079071.2	Q53R12	T4S20_HUMAN	transmembrane 4 L six family member 20	76						integral to membrane|plasma membrane		p.A76V(1)		breast(1)|kidney(2)|large_intestine(1)|lung(4)|stomach(2)	10		Renal(207;0.025)|all_lung(227;0.123)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;3.8e-11)|all cancers(144;2.57e-08)|Lung(261;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0115)		GTTGCAGCACGCTCTTTTTCT	0.428000													52	463					0	0	0.870114	0	0
MYH8	4626	broad.mit.edu	37	17	10297708	10297708	+	Missense_Mutation	SNP	G	G	A			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr17:10297708G>A	ENST00000403437.2	-	35	5118	c.5024C>T	c.(5023-5025)gCa>gTa	p.A1675V	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1675					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CTCCACAATTGCCAGCTGTTC	0.542000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				9	65					0	0	0.361761	0	0
HELZ2	85441	broad.mit.edu	37	20	62194306	62194306	+	Missense_Mutation	SNP	C	C	T			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr20:62194306C>T	ENST00000467148.1	-	8	5938	c.5869G>A	c.(5869-5871)Gcg>Acg	p.A1957T	HELZ2_ENST00000427522.2_Missense_Mutation_p.A1388T	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		TCGGCAACCGCGCCGGTGGCC	0.687000													5	4					0	0	0.184627	0	0
GPNMB	10457	broad.mit.edu	37	7	23313757	23313757	+	Missense_Mutation	SNP	C	C	T			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr7:23313757C>T	ENST00000258733.4	+	11	1892	c.1597C>T	c.(1597-1599)Ctc>Ttc	p.L533F	GPNMB_ENST00000381990.2_Missense_Mutation_p.L545F|GPNMB_ENST00000539136.1_Missense_Mutation_p.L434F|GPNMB_ENST00000453162.2_Missense_Mutation_p.L487F|GPNMB_ENST00000478451.1_3'UTR			Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb	545					negative regulation of cell proliferation	melanosome				breast(5)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(3)|stomach(2)	41			GBM - Glioblastoma multiforme(13;0.154)			GAGTGTCTTTCTCAACCGTGC	0.403000													6	99					0	0	0.248553	0	0
GIGYF2	26058	broad.mit.edu	37	2	233675977	233675977	+	Missense_Mutation	SNP	C	C	T			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr2:233675977C>T	ENST00000373566.3	+	18	2185	c.1988C>T	c.(1987-1989)gCc>gTc	p.A663V	GIGYF2_ENST00000409480.1_Missense_Mutation_p.A663V|GIGYF2_ENST00000409547.1_Missense_Mutation_p.A641V|GIGYF2_ENST00000452341.2_Missense_Mutation_p.A472V|GIGYF2_ENST00000409451.3_Missense_Mutation_p.A662V|GIGYF2_ENST00000409196.3_Missense_Mutation_p.A635V|GIGYF2_ENST00000373563.4_Missense_Mutation_p.A641V			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	641	Gln-rich.				cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		CAGGTTTTGGCCCAACAGCAG	0.428000													3	43					0	0	0.115264	0	0
SPATA16	83893	broad.mit.edu	37	3	172835272	172835272	+	Missense_Mutation	SNP	G	G	A	rs144256069	by1000genomes	TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr3:172835272G>A	ENST00000351008.3	-	2	433	c.250C>T	c.(250-252)Cgg>Tgg	p.R84W		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	84					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			TCTGCCTTCCGTTTAAAGGCT	0.398000													12	268					0	0	0.435327	0	0
LINC00969	440993	broad.mit.edu	37	3	195395399	195395399	+	RNA	SNP	G	G	A	rs62287990	by1000genomes	TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr3:195395399G>A	ENST00000445430.1	+	0	806																											GGCTACGGGCGCACCTACTTG	0.607000													5	42					0	0	0.335167	0	0
POTEF	728378	broad.mit.edu	37	2	130832473	130832473	+	Missense_Mutation	SNP	C	C	T			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr2:130832473C>T	ENST00000357462.5	-	15	2665	c.2572G>A	c.(2572-2574)Ggg>Agg	p.G858R	POTEF_ENST00000409914.2_Missense_Mutation_p.G858R			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	858	Actin-like.					cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						TGGGTGACCCCGTCACCAGAG	0.607000													8	78					0	0	0.307466	0	0
MUC2	4583	broad.mit.edu	37	11	1092904	1092904	+	Missense_Mutation	SNP	C	C	A			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr11:1092904C>A	ENST00000441003.2	+	30	4750	c.4723C>A	c.(4723-4725)Ccc>Acc	p.P1575T	MUC2_ENST00000359061.5_Missense_Mutation_p.P1576T|MUC2_ENST00000361558.6_Intron	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	1578	Approximate repeats.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	aaccccaacacccaccggcac	0.642000													2	2					0.0016	0.00195	0.115264	1	0
TRO	7216	broad.mit.edu	37	X	54955458	54955458	+	Silent	SNP	C	C	T			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chrX:54955458C>T	ENST00000173898.7	+	12	2413	c.2301C>T	c.(2299-2301)gcC>gcT	p.A767A	TRO_ENST00000319167.8_Intron|TRO_ENST00000375022.4_Intron|TRO_ENST00000399736.1_Intron|TRO_ENST00000375041.2_Silent_p.A370A|TRO_ENST00000420798.2_Silent_p.A298A	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	767	62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						GCACCAGTGCCAGCTTCAGCA	0.542000													7	41					0	0	0.248553	0	0
ARID1A	8289	broad.mit.edu	37	1	27105895	27105896	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr1:27105895_27105896insA	ENST00000324856.7	+	20	5877_5878	c.5506_5507insA	c.(5506-5508)gttfs	p.V1836fs	ARID1A_ENST00000457599.2_Frame_Shift_Ins_p.V1619fs|ARID1A_ENST00000540690.1_Frame_Shift_Ins_p.V164fs|ARID1A_ENST00000374152.2_Frame_Shift_Ins_p.V1453fs	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1836					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCGTGTGCAGGAGTTTGACAGT	0.535			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								7	100	---	---	---	---					
BAP1	8314	broad.mit.edu	37	3	52437530	52437533	+	Frame_Shift_Del	DEL	ATGC	ATGC	-			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr3:52437530_52437533delATGC	ENST00000460680.1	-	13	2099_2102	c.1628_1631delGCAT	c.(1627-1632)tafs	p.CI543fs	BAP1_ENST00000296288.5_Frame_Shift_Del_p.CI525fs	NM_004656.2	NP_004647.1	Q92560	BAP1_HUMAN	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	543					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			NS(1)|breast(4)|endometrium(3)|eye(42)|kidney(60)|large_intestine(3)|lung(9)|ovary(4)|pleura(39)|prostate(4)|skin(9)|urinary_tract(2)	180				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		GTTGTAGCGTATGCAGTCAACACG	0.618			"""N, Mis, F, S, O"""		"""uveal melanoma, breast, NSCLC, RCC"""	"""mesothelioma, uveal melanoma"""							9	75	---	---	---	---					
BTNL9	153579	broad.mit.edu	37	5	180486849	180486849	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr5:180486849delT	ENST00000327705.9	+	11	1826	c.1595delT	c.(1594-1596)cgfs	p.L532fs	BTNL9_ENST00000376842.3_Frame_Shift_Del_p.L533fs	NM_152547.4	NP_689760.2	Q6UXG8	BTNL9_HUMAN	butyrophilin-like 9	532						integral to membrane				breast(2)|central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(10)|ovary(1)	19	all_cancers(89;2.45e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GACCCCGCCCTGGACTGGTGG	0.711													2	4	---	---	---	---					
NSUN5P1	155400	broad.mit.edu	37	7	75045497	75045497	+	RNA	DEL	G	G	-			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr7:75045497delG	ENST00000393633.2	+	0	4280																				large_intestine(1)|lung(1)	2						GGGTCGTGGAGGGGGGGGATG	0.657													2	4	---	---	---	---					
FRMPD2	143162	broad.mit.edu	37	10	49379224	49379224	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr10:49379224delT	ENST00000374201.3	-	26	3553	c.3251delA	c.(3250-3252)agfs	p.K1084fs	FRMPD2_ENST00000407470.4_Frame_Shift_Del_p.K1052fs|FRMPD2_ENST00000463706.1_5'UTR|FRMPD2_ENST00000474573.1_Frame_Shift_Del_p.K36fs|FRMPD2_ENST00000305531.3_Frame_Shift_Del_p.K1059fs	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	1084	PDZ 3.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		ATTGGCATTCTTTTTTAGTTT	0.398													4	2	---	---	---	---					
POU4F1	5457	broad.mit.edu	37	13	79176484	79176486	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr13:79176484_79176486delTGG	ENST00000377208.5	-	2	535_537	c.324_326delCCA	c.(322-327)cag>ca	p.HQ108del	RNF219-AS1_ENST00000430549.2_RNA|RNF219-AS1_ENST00000607220.1_RNA|RNF219-AS1_ENST00000560584.2_RNA|RNF219-AS1_ENST00000606376.1_RNA|RNF219-AS1_ENST00000606124.1_RNA|RNF219-AS1_ENST00000560209.2_RNA|RNF219-AS1_ENST00000607860.1_RNA|RNF219-AS1_ENST00000444769.3_RNA|RNF219-AS1_ENST00000606429.1_RNA|RNF219-AS1_ENST00000607205.1_RNA	NM_006237.3	NP_006228.3	Q01851	PO4F1_HUMAN	POU class 4 homeobox 1	108	Poly-His.				axonogenesis|regulation of transcription from RNA polymerase II promoter|synapse assembly	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.H108delH(1)		central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(5)|ovary(1)	16		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.129)		TTCGAGCGCCtggtggtggtggt	0.729													2	4	---	---	---	---					
IGHV3-23	28442	broad.mit.edu	37	14	106725714	106725715	+	RNA	INS	-	-	G			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr14:106725714_106725715insG	ENST00000390609.2	-	0	18_19																											ATCCCAGGGCTGGGCTCCTCTC	0.500													7	55	---	---	---	---					
ZNF559	84527	broad.mit.edu	37	19	9452027	9452028	+	Frame_Shift_Del	DEL	CT	CT	-	rs55837495		TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr19:9452027_9452028delCT	ENST00000592504.1	+	6	665_666	c.410_411delCT	c.(409-411)afs	p.T137fs	ZNF177_ENST00000602738.1_Intron|ZNF177_ENST00000605471.1_Intron|ZNF177_ENST00000602856.1_Intron|ZNF559_ENST00000592896.1_Intron|ZNF559_ENST00000393883.2_Intron|ZNF177_ENST00000446085.4_Intron|ZNF559_ENST00000587557.1_Intron|ZNF559_ENST00000603380.1_Intron|ZNF559_ENST00000586255.1_Intron|ZNF559_ENST00000585352.1_Intron|ZNF177_ENST00000541595.2_Intron|ZNF559_ENST00000538743.1_Intron|ZNF559_ENST00000317221.7_Intron			Q9BR84	ZN559_HUMAN	zinc finger protein 559	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(7)|lung(15)|ovary(1)|urinary_tract(1)	26						TTGACAAACACTCTAAACATCC	0.347													2	4	---	---	---	---					
U2AF2	11338	broad.mit.edu	37	19	56185302	56185302	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CW-6097-01A-11D-1669-08	TCGA-CW-6097-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3cfe810-7b8c-4c3e-a49a-eea4d1ae9533	c3a6d147-8cb9-4088-b340-278ccad97903	g.chr19:56185302delC	ENST00000450554.2	+	12	2243	c.1284delC	c.(1282-1284)atfs	p.I428fs	CTD-2537I9.12_ENST00000585940.1_RNA|CTD-2537I9.12_ENST00000589456.1_RNA|U2AF2_ENST00000308924.4_Frame_Shift_Del_p.I432fs|U2AF2_ENST00000590551.1_Frame_Shift_Del_p.I264fs	NM_001012478.1|NM_007279.2	NP_001012496.1|NP_009210.1	P26368	U2AF2_HUMAN	U2 small nuclear RNA auxiliary factor 2	432	RRM 3.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			biliary_tract(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(2)	21		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		CCCCACAGATCTTTGTGGAGT	0.567													12	104	---	---	---	---					
