Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
EXOSC10	5394	broad.mit.edu	37	1	11151600	11151600	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:11151600G>A	uc001asa.2	-	4	477	c.427C>T	c.(427-429)CCT>TCT	p.P143S	EXOSC10_uc001asb.2_Missense_Mutation_p.P143S|EXOSC10_uc009vmy.1_Missense_Mutation_p.P143S	NM_001001998	NP_001001998	Q01780	EXOSX_HUMAN	exosome component 10 isoform 1	143					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			upper_aerodigestive_tract(1)	1	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		AAGCCGGCAGGGAGGACAGGC	0.463	Colon(179;105 1987 14326 27364 29542)		NA											10	51					0	0	0.008291	0	0
AADACL4	343066	broad.mit.edu	37	1	12711299	12711299	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:12711299C>T	uc001auf.2	+	2	326	c.326C>T	c.(325-327)TCC>TTC	p.S109F		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	109	Lumenal (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		GCAGCATCCTCCAGACCCCGG	0.562			NA											21	52					0	0	0.014323	0	0
PADI4	23569	broad.mit.edu	37	1	17668890	17668890	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:17668890G>A	uc001baj.2	+	8	956	c.928G>A	c.(928-930)GCG>ACG	p.A310T	PADI4_uc009vpc.2_Missense_Mutation_p.A310T	NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	310					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	GGAGGTGTACGCGTGCAGGTG	0.627			NA											8	21					0	0	0.00308	0	0
CSMD2	114784	broad.mit.edu	37	1	34006261	34006261	+	Silent	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:34006261C>T	uc001bxn.1	-	59	9092	c.9063G>A	c.(9061-9063)GGG>GGA	p.G3021G	CSMD2_uc001bxm.1_Silent_p.G3165G	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3021	Sushi 23.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCACCACCTTCCCATTGGGGA	0.602			NA											27	88					0	0	0.005443	0	0
HMGB4	127540	broad.mit.edu	37	1	34330081	34330081	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:34330081C>T	uc001bxp.2	+	2	2032	c.289C>T	c.(289-291)CCA>TCA	p.P97S	CSMD2_uc001bxm.1_Intron|CSMD2_uc001bxn.1_Intron|HMGB4_uc001bxq.2_Missense_Mutation_p.P23S	NM_145205	NP_660206	Q8WW32	HMGB4_HUMAN	HMG2 like isoform 1	97						nucleus	DNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CAGACGGCCTCCATCATCCTT	0.542			NA											26	131					0	0	0.004656	0	0
CTPS	1503	broad.mit.edu	37	1	41456895	41456895	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:41456895G>A	uc001cgk.3	+	6	1122	c.614G>A	c.(613-615)AGA>AAA	p.R205K	CTPS_uc010ojo.1_5'UTR|CTPS_uc010ojp.1_Missense_Mutation_p.R212K|CTPS_uc001cgl.3_Missense_Mutation_p.R205K|CTPS_uc010ojq.1_Missense_Mutation_p.R49K	NM_001905	NP_001896	P17812	PYRG1_HUMAN	CTP synthase	205					CTP biosynthetic process|glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|response to drug	cytosol	ATP binding|CTP synthase activity|protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)			L-Glutamine(DB00130)	CGGGAACTTAGAGGACTTGGG	0.388			NA											14	51					0	0	0.004007	0	0
CC2D1B	200014	broad.mit.edu	37	1	52824928	52824928	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:52824928T>A	uc001ctq.1	-	10	1258	c.1120A>T	c.(1120-1122)ACC>TCC	p.T374S	CC2D1B_uc001ctr.2_5'Flank|CC2D1B_uc001cts.2_Missense_Mutation_p.T65S	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	374										ovary(2)	2						CTACCTGGGGTTGCTGGGACG	0.627			NA											19	44					0	0	0.006122	0	0
PTGFR	5737	broad.mit.edu	37	1	78959135	78959135	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:78959135A>T	uc001din.2	+	2	973	c.707A>T	c.(706-708)CAG>CTG	p.Q236L	PTGFR_uc001dim.2_Missense_Mutation_p.Q236L	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	236	Cytoplasmic (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	AAAAGTCAGCAGCACAGACAA	0.413			NA											21	64					0	0	0.004656	0	0
SYT6	148281	broad.mit.edu	37	1	114680333	114680333	+	Silent	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:114680333C>A	uc001eev.2	-	3	850	c.600G>T	c.(598-600)GTG>GTT	p.V200V		NM_205848	NP_995320	Q5T7P8	SYT6_HUMAN	synaptotagmin VI	285	Cytoplasmic (Potential).|C2 1.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCTTGCGGTGCACCCGGGTCT	0.552			NA											20	40					6.44725e-10	8.32044e-10	0.014323	1	0
PRKAB2	5565	broad.mit.edu	37	1	146639438	146639438	+	Silent	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:146639438C>T	uc001epe.2	-	3	376	c.231G>A	c.(229-231)CGG>CGA	p.R77R	PRKAB2_uc010ozm.1_Intron|PRKAB2_uc010ozn.1_Intron|PRKAB2_uc009wjf.1_Silent_p.R77R	NM_005399	NP_005390	O43741	AAKB2_HUMAN	AMP-activated protein kinase beta 2	77					carnitine shuttle|cell cycle arrest|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm				lung(2)|skin(1)	3	all_hematologic(923;0.0487)				Adenosine monophosphate(DB00131)	TAACAGTGGGCCGGGCCTGCT	0.522			NA											63	333					0	0	0.01441	0	0
RIT1	6016	broad.mit.edu	37	1	155874261	155874261	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:155874261C>A	uc001fmh.1	-	5	457	c.270G>T	c.(268-270)ATG>ATT	p.M90I	RIT1_uc010pgr.1_Missense_Mutation_p.M54I	NM_006912	NP_008843	Q92963	RIT1_HUMAN	Ras-like without CAAX 1	90					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			breast(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;1.79e-05)			CTCCTGCCCTCATATACTGGT	0.433			NA											21	47					6.44725e-10	8.32044e-10	0.014323	1	0
PAPPA2	60676	broad.mit.edu	37	1	176811543	176811543	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:176811543C>A	uc001gkz.2	+	23	6493	c.5329C>A	c.(5329-5331)CTG>ATG	p.L1777M	PAPPA2_uc009www.2_RNA|uc001gla.1_5'Flank	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1777					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TGACTGTGACCTGGATGAGTG	0.488			NA											17	32					5.26018e-13	7.28039e-13	0.012319	1	0
FAM5B	57795	broad.mit.edu	37	1	177249934	177249934	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:177249934G>A	uc001glf.2	+	8	1934	c.1622G>A	c.(1621-1623)TGG>TAG	p.W541*	FAM5B_uc001glg.2_Nonsense_Mutation_p.W436*	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	541						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CTGGGCAGCTGGTTTGACCCT	0.552			NA											4	30					0	0	0.009096	0	0
KIF21B	23046	broad.mit.edu	37	1	200969648	200969648	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:200969648C>A	uc001gvs.1	-	11	1872	c.1555G>T	c.(1555-1557)GCT>TCT	p.A519S	KIF21B_uc001gvr.1_Missense_Mutation_p.A519S|KIF21B_uc009wzl.1_Missense_Mutation_p.A519S|KIF21B_uc010ppn.1_Missense_Mutation_p.A519S	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	519	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GCTGGAGAAGCACCCAGGGAG	0.657			NA											21	88					9.95505e-16	1.42964e-15	0.014323	1	0
PPFIA4	8497	broad.mit.edu	37	1	203020922	203020922	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:203020922G>C	uc001gyz.2	+	1	612	c.19G>C	c.(19-21)GTG>CTG	p.V7L	PPFIA4_uc009xaj.2_Missense_Mutation_p.V664L|PPFIA4_uc010pqf.1_Missense_Mutation_p.V220L|PPFIA4_uc001gza.2_Missense_Mutation_p.V7L	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f	7					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						TGCAGCAGACGTGCGGTTCTC	0.637			NA											6	24					0	0	0.001168	0	0
CR1	1378	broad.mit.edu	37	1	207737275	207737275	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:207737275C>T	uc001hfy.2	+	14	2443	c.2303C>T	c.(2302-2304)CCC>CTC	p.P768L	CR1_uc009xcl.1_Intron|CR1_uc001hfx.2_Missense_Mutation_p.P1218L|CR1_uc009xck.1_Intron	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	768	Sushi 12.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						AACTTTTCACCCGGGCAGGAA	0.577			NA											4	96					0	0	0.001168	0	0
PLXNA2	5362	broad.mit.edu	37	1	208216417	208216417	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:208216417G>A	uc001hgz.2	-	21	4764	c.4006C>T	c.(4006-4008)CGG>TGG	p.R1336W		NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	1336	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		TCCAGCTCCCGCAGGACGGGG	0.607			NA											25	40					0	0	0.009535	0	0
RYR2	6262	broad.mit.edu	37	1	237765338	237765338	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:237765338C>A	uc001hyl.1	+	35	4730	c.4610C>A	c.(4609-4611)ACA>AAA	p.T1537K		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1537	Cytoplasmic (By similarity).|B30.2/SPRY 3.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAACCGAGTACAAAATTATTT	0.308			NA											8	29					0.000442599	0.000491491	0.006214	1	0
FMN2	56776	broad.mit.edu	37	1	240255621	240255621	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:240255621G>A	uc010pyd.1	+	1	437	c.212G>A	c.(211-213)AGA>AAA	p.R71K	FMN2_uc010pye.1_Missense_Mutation_p.R71K	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	71					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TCCGACTCCAGAGCCTCGGTG	0.557			NA											3	15					0	0	0.004672	0	0
CHML	1122	broad.mit.edu	37	1	241797243	241797243	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:241797243G>A	uc001hzd.2	-	1	1990	c.1826C>T	c.(1825-1827)CCA>CTA	p.P609L	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	609					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			ATTTGGAGGTGGAGGGCAGAA	0.473			NA											23	83					0	0	0.014323	0	0
OR2B11	127623	broad.mit.edu	37	1	247615143	247615143	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:247615143C>T	uc010pyx.1	-	1	142	c.142G>A	c.(142-144)GCC>ACC	p.A48T		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	48	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			AGGATGATGGCGACGTTCCCC	0.582			NA											40	126					0	0	0.00623	0	0
OR2C3	81472	broad.mit.edu	37	1	247695442	247695442	+	Silent	SNP	G	G	A	rs148160393	byFrequency	TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:247695442G>A	uc009xgy.2	-	2	734	c.372C>T	c.(370-372)TAC>TAT	p.Y124Y	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	124	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			AGATGGCAGCGTAGCGGTCAT	0.562			NA											4	32					0	0	0.009096	0	0
OR14A16	284532	broad.mit.edu	37	1	247978952	247978952	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:247978952A>G	uc001idm.1	-	1	80	c.80T>C	c.(79-81)ATT>ACT	p.I27T		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	27	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CAAGAAGAGAATCGAATGCAA	0.393	Ovarian(112;180 1586 15073 21914 33526)		NA											13	48					0	0	0.00245	0	0
OR14C36	127066	broad.mit.edu	37	1	248512808	248512808	+	Silent	SNP	G	G	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:248512808G>T	uc010pzl.1	+	1	732	c.732G>T	c.(730-732)CTG>CTT	p.L244L		NM_001001918	NP_001001918	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C,	244	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CTCACATCCTGGTGGTGTCAG	0.498			NA											18	80					1.02788e-11	1.40233e-11	0.00499	1	0
OR2T6	254879	broad.mit.edu	37	1	248550951	248550951	+	Silent	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:248550951C>T	uc001iei.1	+	1	42	c.42C>T	c.(40-42)CTC>CTT	p.L14L		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCTTTACCCTCATGGGGCTCT	0.423			NA											15	124					0	0	0.005443	0	0
KIF5B	3799	broad.mit.edu	37	10	32307277	32307277	+	Silent	SNP	G	G	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr10:32307277G>C	uc001iwe.3	-	22	2876	c.2406C>G	c.(2404-2406)CTC>CTG	p.L802L		NM_004521	NP_004512	P33176	KINH_HUMAN	kinesin family member 5B	802					stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(4)	lung(4)|ovary(1)	5		Prostate(175;0.0137)				CCTGAACAAAGAGTTTGCGCA	0.368			NA											10	86					0	0	0.013537	0	0
PARD3	56288	broad.mit.edu	37	10	34400444	34400444	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr10:34400444G>A	uc010qej.1	-	25	3724	c.3724C>T	c.(3724-3726)CAG>TAG	p.Q1242*	PARD3_uc010qek.1_Nonsense_Mutation_p.Q1239*|PARD3_uc010qel.1_Nonsense_Mutation_p.Q1205*|PARD3_uc010qem.1_Nonsense_Mutation_p.Q1226*|PARD3_uc010qen.1_Nonsense_Mutation_p.Q1196*|PARD3_uc010qeo.1_Nonsense_Mutation_p.Q1159*|PARD3_uc010qep.1_Nonsense_Mutation_p.Q1152*|PARD3_uc010qeq.1_Nonsense_Mutation_p.Q1130*|uc001ixe.1_5'Flank	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	1242					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				GAGTAGTTCTGCTCCCAAGAG	0.557			NA											21	60					0	0	0.00333	0	0
TNKS2	80351	broad.mit.edu	37	10	93621874	93621874	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr10:93621874C>G	uc001khp.2	+	26	3697	c.3400C>G	c.(3400-3402)CTA>GTA	p.L1134V		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	1134	PARP catalytic.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				TGTAAATGGCCTAGCATTAGC	0.398			NA											6	48					0	0	0.001984	0	0
PDCD11	22984	broad.mit.edu	37	10	105166430	105166430	+	Silent	SNP	A	A	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr10:105166430A>G	uc001kwy.1	+	7	840	c.753A>G	c.(751-753)GGA>GGG	p.G251G		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	251	S1 motif 2.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GCAACGGAGGAGTTGTTAGTC	0.483			NA											23	63					0	0	0.014323	0	0
IRF7	3665	broad.mit.edu	37	11	614252	614252	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr11:614252A>G	uc001lqh.2	-	6	971	c.601T>C	c.(601-603)TGG>CGG	p.W201R	IRF7_uc009ycb.2_Missense_Mutation_p.W95R|IRF7_uc010qwf.1_Missense_Mutation_p.W200R|IRF7_uc001lqf.2_Intron|IRF7_uc010qwg.1_Intron|IRF7_uc001lqg.2_Missense_Mutation_p.W214R|IRF7_uc001lqi.2_Missense_Mutation_p.W201R|IRF7_uc010qwh.1_Intron	NM_001572	NP_001563	Q92985	IRF7_HUMAN	interferon regulatory factor 7 isoform a	201					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of interferon-alpha production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;7.68e-28)|Epithelial(43;7.44e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;6.96e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCTGCCCCCCATGACGCTGTC	0.677			NA											11	18					0	0	0.008291	0	0
ZNF195	7748	broad.mit.edu	37	11	3380496	3380496	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr11:3380496T>C	uc001lxt.2	-	6	1920	c.1742A>G	c.(1741-1743)GAC>GGC	p.D581G	uc001lxr.2_5'Flank|ZNF195_uc001lxv.2_Missense_Mutation_p.D558G|ZNF195_uc001lxs.2_Missense_Mutation_p.D509G|ZNF195_uc010qxr.1_Missense_Mutation_p.D562G|ZNF195_uc009ydz.2_Missense_Mutation_p.D536G|ZNF195_uc001lxu.2_Missense_Mutation_p.D513G	NM_001130520	NP_001123992	O14628	ZN195_HUMAN	zinc finger protein 195 isoform 1	581	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		TCCACATTCGTCACATTTGTA	0.403			NA											3	112					0	0	0.004672	0	0
OR52N2	390077	broad.mit.edu	37	11	5841596	5841596	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr11:5841596C>A	uc010qzp.1	+	1	31	c.31C>A	c.(31-33)CCA>ACA	p.P11T	TRIM5_uc001mbq.1_Intron	NM_001005174	NP_001005174	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGCCTGACCCCAGGATTCTT	0.512			NA											28	85					1.7881e-09	2.27685e-09	0.008361	1	0
C11orf17	56672	broad.mit.edu	37	11	8933196	8933196	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr11:8933196C>G	uc001mgx.2	+	2	276	c.200C>G	c.(199-201)CCG>CGG	p.P67R	ST5_uc001mgv.2_5'Flank|C11orf17_uc001mgz.2_Missense_Mutation_p.P67R|C11orf17_uc001mgy.2_Missense_Mutation_p.P67R|C11orf17_uc010rbr.1_Missense_Mutation_p.P67R|C11orf17_uc010rbs.1_Missense_Mutation_p.P67R|C11orf17_uc001mha.2_Missense_Mutation_p.P67R	NM_020642	NP_065693	Q9NQ31	AKIP1_HUMAN	chromosome 11 open reading frame 17	67						nucleus	protein binding				0				Epithelial(150;5.08e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0243)		GCAGCCGGCCCGCAGCGCGTT	0.741			NA											3	6					0	0	0.009096	0	0
F2	2147	broad.mit.edu	37	11	46748375	46748375	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr11:46748375G>A	uc001ndf.3	+	9	1161	c.1118G>A	c.(1117-1119)GGC>GAC	p.G373D	F2_uc001ndg.3_RNA	NM_000506	NP_000497	P00734	THRB_HUMAN	coagulation factor II preproprotein	373	Peptidase S1.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity			ovary(3)	3		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	GCAGAGATCGGCATGTCACCT	0.617	Esophageal Squamous(147;1147 1808 2148 38609 51144)		NA											4	111					0	0	0.001168	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735567	55735567	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr11:55735567G>C	uc010rit.1	-	1	373	c.373C>G	c.(373-375)CTA>GTA	p.L125V		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	125	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					TTCATCACTAGAGGATACTGC	0.438			NA											7	30					0	0	0.001984	0	0
OR8H1	219469	broad.mit.edu	37	11	56057967	56057967	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr11:56057967G>T	uc010rje.1	-	1	572	c.572C>A	c.(571-573)ACA>AAA	p.T191K		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					AATGTCGTATGTGTCCATGCA	0.433			NA											29	69					1.7881e-09	2.27685e-09	0.008361	1	0
OSBP	5007	broad.mit.edu	37	11	59376080	59376080	+	Silent	SNP	T	T	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr11:59376080T>A	uc001noc.1	-	3	1179	c.699A>T	c.(697-699)ACA>ACT	p.T233T		NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	233					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GCTGCAGAGCTGTGCCATGCT	0.498			NA											22	77					0	0	0.010504	0	0
MS4A15	219995	broad.mit.edu	37	11	60531432	60531432	+	Splice_Site	SNP	G	G	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr11:60531432G>T	uc009ynf.1	+	2	445	c.225_splice	c.e2+1	p.G75_splice	MS4A15_uc001npx.2_Intron|MS4A15_uc001npy.2_Splice_Site|MS4A15_uc009yng.1_Splice_Site_p.G75_splice	NM_001098835	NP_001092305	Q8N5U1	M4A15_HUMAN	membrane-spanning 4-domains, subfamily A, member							integral to membrane	receptor activity			lung(1)	1						AGTTTTGGGGGTAAGAACAGC	0.557			NA											6	12					0.00116845	0.00127527	0.001168	1	0
CLPB	81570	broad.mit.edu	37	11	72006575	72006575	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr11:72006575C>A	uc001osj.2	-	13	1587	c.1537G>T	c.(1537-1539)GCT>TCT	p.A513S	CLPB_uc010rqx.1_Missense_Mutation_p.A468S|CLPB_uc010rqy.1_Missense_Mutation_p.A454S|CLPB_uc001osk.2_Missense_Mutation_p.A483S|CLPB_uc009ytg.2_RNA|CLPB_uc010rqz.1_Missense_Mutation_p.A312S|CLPB_uc001osi.2_Missense_Mutation_p.A121S	NM_030813	NP_110440	Q9H078	CLPB_HUMAN	caseinolytic peptidase B	513					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			pancreas(1)	1						ATCTCCAAAGCTTCCTGCCTC	0.567			NA											12	34					1.49906e-05	1.72482e-05	0.00245	1	0
FAT3	120114	broad.mit.edu	37	11	92531077	92531077	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr11:92531077C>A	uc001pdj.3	+	9	4915	c.4898C>A	c.(4897-4899)ACG>AAG	p.T1633K		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1633	Cadherin 15.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GACATGACGACGATGGGTCAG	0.458			NA								TCGA Ovarian(4;0.039)			20	69					1.15919e-05	1.34185e-05	0.008871	1	0
KDM4D	55693	broad.mit.edu	37	11	94731100	94731100	+	Silent	SNP	G	G	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr11:94731100G>C	uc001pfe.2	+	3	1396	c.564G>C	c.(562-564)ACG>ACC	p.T188T		NM_018039	NP_060509	Q6B0I6	KDM4D_HUMAN	jumonji domain containing 2D	188	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GGAAAACCACGTTTGCTTGGC	0.512			NA											28	97					0	0	0.00632	0	0
MMP12	4321	broad.mit.edu	37	11	102743653	102743653	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr11:102743653G>T	uc001phk.2	-	2	337	c.292C>A	c.(292-294)CAT>AAT	p.H98N		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	98					positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	CTGAAATGATGGACATCGGGG	0.507			NA											9	27					1.12685e-05	1.31237e-05	0.004482	1	0
PDGFD	80310	broad.mit.edu	37	11	103780477	103780477	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr11:103780477T>C	uc001phq.2	-	7	1430	c.1058A>G	c.(1057-1059)CAG>CGG	p.Q353R	PDGFD_uc001php.2_Missense_Mutation_p.Q347R	NM_025208	NP_079484	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D isoform 1	353					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		GTGATCCAACTGGATGTCAAC	0.448			NA											28	130					0	0	0.00632	0	0
FGF23	8074	broad.mit.edu	37	12	4479687	4479687	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr12:4479687A>T	uc001qmq.1	-	3	724	c.578T>A	c.(577-579)CTG>CAG	p.L193Q		NM_020638	NP_065689	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23 precursor	193					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			ovary(2)|breast(1)|skin(1)	4			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			CCGGGGCTTCAGCACGTTCAG	0.682			NA											4	36					0	0	0.009096	0	0
KCNA1	3736	broad.mit.edu	37	12	5021401	5021401	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr12:5021401C>T	uc001qnh.2	+	2	1962	c.857C>T	c.(856-858)ACC>ATC	p.T286I		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	286					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GAGCAGGCCACCTCCCTGGCC	0.542			NA											25	71					0	0	0.004656	0	0
PUS7L	83448	broad.mit.edu	37	12	44148626	44148626	+	Silent	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr12:44148626G>A	uc001rnq.3	-	2	912	c.423C>T	c.(421-423)GCC>GCT	p.A141A	PUS7L_uc001rnr.3_Silent_p.A141A|PUS7L_uc001rns.3_Silent_p.A141A|PUS7L_uc009zkb.2_Intron	NM_001098615	NP_001092085	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S.	141					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			pancreas(1)	1	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		TTACATCACAGGCAAAATTAT	0.368			NA											14	45					0	0	0.00245	0	0
BAZ2A	11176	broad.mit.edu	37	12	57003980	57003980	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr12:57003980A>T	uc001slq.1	-	9	1999	c.1805T>A	c.(1804-1806)GTA>GAA	p.V602E	BAZ2A_uc001slp.1_Missense_Mutation_p.V600E|BAZ2A_uc009zow.1_Missense_Mutation_p.V570E	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	602	MBD.				chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						GACACTGTGTACCACGTTGCG	0.488			NA											34	92					0	0	0.005524	0	0
KIF5A	3798	broad.mit.edu	37	12	57974844	57974844	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr12:57974844G>A	uc001sor.1	+	24	2852	c.2644G>A	c.(2644-2646)GCC>ACC	p.A882T	KIF5A_uc010srr.1_Missense_Mutation_p.A793T	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	882					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						ACTGAAGGAGGCCAAGGAGGG	0.577			NA											11	20					0	0	0.010729	0	0
SYT1	6857	broad.mit.edu	37	12	79689917	79689917	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr12:79689917C>A	uc001sys.2	+	8	1214	c.543C>A	c.(541-543)TAC>TAA	p.Y181*	SYT1_uc001syt.2_Nonsense_Mutation_p.Y181*|SYT1_uc001syu.2_Nonsense_Mutation_p.Y178*|SYT1_uc001syv.2_Nonsense_Mutation_p.Y181*	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	181	Cytoplasmic (Potential).|Phospholipid binding (Probable).|C2 1.				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						CTGATCCTTACGTGAAAGTGT	0.433			NA											11	49					5.50884e-06	6.45514e-06	0.013537	1	0
NOS1	4842	broad.mit.edu	37	12	117726019	117726019	+	Silent	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr12:117726019C>A	uc001twm.1	-	5	1673	c.987G>T	c.(985-987)ACG>ACT	p.T329T		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	329					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CAGTGCATCCCGTTTCCTGGA	0.512	Esophageal Squamous(162;1748 2599 51982 52956)		NA											19	68					1.96292e-10	2.58564e-10	0.010504	1	0
KBTBD7	84078	broad.mit.edu	37	13	41766583	41766583	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr13:41766583A>G	uc001uxw.1	-	1	2120	c.1811T>C	c.(1810-1812)CTT>CCT	p.L604P	uc001uxv.1_Intron	NM_032138	NP_115514	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	604	Kelch 5.						protein binding			ovary(1)	1		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		AAACTGCAAAAGGCCTAACAT	0.423			NA											3	141					0	0	0.004672	0	0
PCDH8	5100	broad.mit.edu	37	13	53418865	53418865	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr13:53418865G>T	uc001vhi.2	-	3	3246	c.3043C>A	c.(3043-3045)CAG>AAG	p.Q1015K	PCDH8_uc001vhj.2_Missense_Mutation_p.Q918K	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	1015	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		TAGACGCTCTGCAGCCCCACT	0.582	GBM(36;25 841 9273 49207)		NA											21	106					1.96292e-10	2.58564e-10	0.010504	1	0
SLITRK1	114798	broad.mit.edu	37	13	84454982	84454982	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr13:84454982G>C	uc001vlk.2	-	1	1547	c.661C>G	c.(661-663)CTC>GTC	p.L221V		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	221	Extracellular (Potential).|LRRCT 1.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TTCAGGGAGAGCAGATCACAG	0.542			NA											11	55					0	0	0.010729	0	0
CDH24	64403	broad.mit.edu	37	14	23517504	23517504	+	Silent	SNP	G	G	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr14:23517504G>C	uc001wil.2	-	13	2405	c.2145C>G	c.(2143-2145)GGC>GGG	p.G715G	CDH24_uc001wik.3_RNA|CDH24_uc010akf.2_Silent_p.G677G	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	715	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		gcgcgggagggccgggcgccg	0.592			NA											8	38					0	0	0.00308	0	0
DHRS2	10202	broad.mit.edu	37	14	24114489	24114489	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr14:24114489T>A	uc001wkt.3	+	9	1328	c.881T>A	c.(880-882)GTG>GAG	p.V294E	DHRS2_uc001wku.3_3'UTR|DHRS2_uc010akv.2_RNA|DHRS2_uc001wkv.3_3'UTR	NM_182908	NP_878912	Q13268	DHRS2_HUMAN	dehydrogenase/reductase member 2 isoform 1	Error:Variant_position_missing_in_Q13268_after_alignment					C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00659)		TGCGTAGCTGTGGTCCCAGGC	0.597			NA											31	87					0	0	0.009535	0	0
GZMH	2999	broad.mit.edu	37	14	25075882	25075882	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr14:25075882C>T	uc001wpr.1	-	5	713	c.668G>A	c.(667-669)GGG>GAG	p.G223E	GZMH_uc010aly.1_Missense_Mutation_p.G137E|GZMH_uc010alz.1_3'UTR	NM_033423	NP_219491	P20718	GRAH_HUMAN	granzyme H precursor	223	Peptidase S1.				apoptosis|cytolysis|proteolysis	cytoplasm	serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(265;0.0267)		TGGAGGTGTCCCTTTTTTGTT	0.517			NA											32	112					0	0	0.009535	0	0
PRKD1	5587	broad.mit.edu	37	14	30066795	30066795	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr14:30066795C>T	uc001wqh.2	-	16	2517	c.2336G>A	c.(2335-2337)GGC>GAC	p.G779D		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	779	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TGGGAATGTGCCGCTTAGGCT	0.463			NA											4	107					0	0	0.009096	0	0
WDR89	112840	broad.mit.edu	37	14	64066555	64066555	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr14:64066555G>A	uc001xgh.2	-	3	352	c.106C>T	c.(106-108)CAA>TAA	p.Q36*	WDR89_uc001xgi.2_Nonsense_Mutation_p.Q36*	NM_001008726	NP_001008726	Q96FK6	WDR89_HUMAN	WD repeat domain 89	36	WD 1.										0				OV - Ovarian serous cystadenocarcinoma(108;0.00543)|all cancers(60;0.0181)|BRCA - Breast invasive adenocarcinoma(234;0.101)		TTTCCTGCTTGGACAGTCTTT	0.348			NA											8	117					0	0	0.006214	0	0
TTLL5	23093	broad.mit.edu	37	14	76231102	76231102	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr14:76231102G>T	uc001xrx.2	+	19	1900	c.1695G>T	c.(1693-1695)AGG>AGT	p.R565S	TTLL5_uc010ask.1_Missense_Mutation_p.R579S|TTLL5_uc001xrz.2_Missense_Mutation_p.R140S|TTLL5_uc001xry.1_RNA	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	565					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		GGGCAATGAGGCCAAAATACC	0.498			NA											8	34					1.76689e-08	2.17727e-08	0.006214	1	0
OR4N3P	390539	broad.mit.edu	37	15	22413903	22413903	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr15:22413903C>G	uc001yuf.2	+	1	202	c.202C>G	c.(202-204)CTG>GTG	p.L68V		NM_001080841	NP_001074310			RecName: Full=Olfactory receptor 4N2; AltName: Full=Olfactory receptor OR14-8; AltName: Full=Olfactory receptor OR14-13;												0						GATGTTGGCTCTGTGGCTTGG	0.502			NA											18	136					0	0	0.008871	0	0
APBA2	321	broad.mit.edu	37	15	29390729	29390729	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr15:29390729G>T	uc001zck.2	+	8	1495	c.1288G>T	c.(1288-1290)GAC>TAC	p.D430Y	APBA2_uc010azj.2_Missense_Mutation_p.D418Y|APBA2_uc010uat.1_Missense_Mutation_p.D418Y|APBA2_uc001zcl.2_Missense_Mutation_p.D418Y|APBA2_uc001zcm.1_Missense_Mutation_p.D122Y	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	430	PID.				nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GACGGAAGTGGACCTCTTCAT	0.408			NA											17	54					8.28177e-16	1.20749e-15	0.007413	1	0
RYR3	6263	broad.mit.edu	37	15	33962735	33962735	+	Silent	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr15:33962735G>A	uc001zhi.2	+	38	5908	c.5838G>A	c.(5836-5838)ACG>ACA	p.T1946T	RYR3_uc010bar.2_Silent_p.T1946T	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1946	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGCAGCCGACGGAGGAGGAGG	0.393			NA											5	98					0	0	0.00308	0	0
SERINC4	619189	broad.mit.edu	37	15	44087738	44087738	+	Silent	SNP	C	C	T	rs74494149		TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr15:44087738C>T	uc010bds.1	-	8	927	c.459G>A	c.(457-459)GGG>GGA	p.G153G	ELL3_uc001zsx.1_5'UTR|SERF2_uc010uee.1_3'UTR|C15orf63_uc001ztb.2_Intron|SERF2_uc001zsz.3_3'UTR|MIR1282_hsa-mir-1282|MI0006429_5'Flank|SERINC4_uc001ztc.1_RNA|SERINC4_uc001ztd.1_Missense_Mutation_p.G41D|SERINC4_uc001zte.1_Silent_p.G153G	NM_001033517	NP_001028689	A6NH21	SERC4_HUMAN	serine incorporator 4	397					phospholipid biosynthetic process	integral to membrane					0		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		GBM - Glioblastoma multiforme(94;7.81e-07)		CACCCCTTTGCCCTGGAGAGA	0.557			NA											4	93					0	0	0.009096	0	0
PIGB	9488	broad.mit.edu	37	15	55611455	55611455	+	Silent	SNP	A	A	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr15:55611455A>C	uc002act.2	+	1	323	c.7A>C	c.(7-9)AGG>CGG	p.R3R	uc002acs.2_5'Flank|PIGB_uc010ugg.1_5'UTR	NM_004855	NP_004846	Q92521	PIGB_HUMAN	phosphatidylinositol glycan, class B	3					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity				0				all cancers(107;0.0255)		AGGGATGAGGAGGCCCCTAAG	0.597			NA											4	18					0	0	0.000602	0	0
PIGB	9488	broad.mit.edu	37	15	55611459	55611459	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr15:55611459C>A	uc002act.2	+	1	327	c.11C>A	c.(10-12)CCC>CAC	p.P4H	uc002acs.2_5'Flank|PIGB_uc010ugg.1_5'UTR	NM_004855	NP_004846	Q92521	PIGB_HUMAN	phosphatidylinositol glycan, class B	4					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity				0				all cancers(107;0.0255)		ATGAGGAGGCCCCTAAGCAAG	0.592			NA											3	19					0.00909568	0.00954547	0.009096	1	0
TMEM202	338949	broad.mit.edu	37	15	72698971	72698971	+	Silent	SNP	T	T	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr15:72698971T>C	uc002auq.2	+	3	366	c.366T>C	c.(364-366)TTT>TTC	p.F122F	TMEM202_uc002aur.2_RNA	NM_001080462	NP_001073931	A6NGA9	TM202_HUMAN	transmembrane protein 202	122	Helical; (Potential).					integral to membrane				central_nervous_system(1)|skin(1)	2						GGGCCTTCTTTCTCATCTCTG	0.463			NA											28	85					0	0	0.003271	0	0
FBXO22	26263	broad.mit.edu	37	15	76222283	76222283	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr15:76222283G>T	uc002bbk.2	+	6	792	c.687G>T	c.(685-687)AAG>AAT	p.K229N	FBXO22_uc002bbj.1_Missense_Mutation_p.K229N|FBXO22_uc002bbl.2_Missense_Mutation_p.K125N	NM_147188	NP_671717	Q8NEZ5	FBX22_HUMAN	F-box only protein 22 isoform a	229					ubiquitin-dependent protein catabolic process		ubiquitin-protein ligase activity				0						ATTGCTGTAAGGTGGGAGCCA	0.428			NA											24	103					5.45024e-15	7.76863e-15	0.00333	1	0
AKAP13	11214	broad.mit.edu	37	15	86266516	86266516	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr15:86266516G>A	uc002blv.1	+	26	6880	c.6710G>A	c.(6709-6711)AGT>AAT	p.S2237N	AKAP13_uc002blu.1_Missense_Mutation_p.S2241N|AKAP13_uc010bnf.1_Missense_Mutation_p.S858N|AKAP13_uc002blw.1_Missense_Mutation_p.S702N|AKAP13_uc002blx.1_Missense_Mutation_p.S482N	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	2237	Interaction with ESR1.|PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						CGTGATGGGAGTGTGTTTCTG	0.413	Melanoma(94;603 1453 3280 32295 32951)		NA											5	67					0	0	0.000602	0	0
ACAN	176	broad.mit.edu	37	15	89382102	89382102	+	Silent	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr15:89382102C>A	uc010upo.1	+	3	653	c.279C>A	c.(277-279)CGC>CGA	p.R93R	ACAN_uc002bmx.2_Silent_p.R93R|ACAN_uc010upp.1_Silent_p.R93R|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	93					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTGAAGGGCGCGTGCGGGTCA	0.622			NA											25	78					2.41591e-17	3.54953e-17	0.004656	1	0
TM2D3	80213	broad.mit.edu	37	15	102191956	102191956	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr15:102191956G>A	uc002bxi.2	-	2	142	c.112C>T	c.(112-114)CAG>TAG	p.Q38*	TM2D3_uc010usg.1_Intron|TM2D3_uc002bxh.2_5'Flank|TM2D3_uc002bxj.2_Intron|TM2D3_uc002bxk.2_5'UTR|TM2D3_uc010ush.1_Nonsense_Mutation_p.Q38*	NM_078474	NP_510883	Q9BRN9	TM2D3_HUMAN	TM2 domain containing 3 isoform a	38						integral to membrane				ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TTTATTGACTGAGCCAGCGCC	0.448			NA											13	180					0	0	0.004007	0	0
MMP25	64386	broad.mit.edu	37	16	3107615	3107615	+	Splice_Site	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr16:3107615G>A	uc002cth.2	+	7	1243	c.1006_splice	c.e7+1	p.G336_splice	uc002ctj.1_Intron	NM_022468	NP_071913	Q9NPA2	MMP25_HUMAN	matrix metalloproteinase 25 preproprotein						inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0						TTCTTCAAAGGTGAGTCATTT	0.398	NSCLC(147;665 1067 3888 6863 19894 30469 40247 45633 51336)		NA											8	104					0	0	0.004482	0	0
XYLT1	64131	broad.mit.edu	37	16	17211541	17211541	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr16:17211541G>T	uc002dfa.2	-	11	2604	c.2519C>A	c.(2518-2520)GCG>GAG	p.A840E		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	840	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						GGTCAGAGGCGCAACGAGGAA	0.542			NA											13	40					4.3838e-07	5.31947e-07	0.001855	1	0
TMC5	79838	broad.mit.edu	37	16	19451966	19451967	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr16:19451966_19451967GG>TT	uc002dgc.3	+	3	1355_1356	c.606_607GG>TT	c.(604-609)CTGGGA>CTTTGA	p.G203*	TMC5_uc010vaq.1_Nonsense_Mutation_p.G203*|TMC5_uc002dgb.3_Nonsense_Mutation_p.G203*|TMC5_uc010var.1_Nonsense_Mutation_p.G203*	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a	203	Extracellular (Potential).					integral to membrane				skin(1)	1						CAGACTCTCTGGGAAAGCCTGA	0.47			NA											33	87					0	0	0.004672	0	0
ITGAX	3687	broad.mit.edu	37	16	31382711	31382711	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr16:31382711C>G	uc002ebu.1	+	16	1965	c.1898C>G	c.(1897-1899)CCC>CGC	p.P633R	ITGAX_uc002ebt.2_Missense_Mutation_p.P633R	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	633	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GCCGAGATCCCCAGGTCTGCG	0.587			NA											10	40					0	0	0.008291	0	0
CDH8	1006	broad.mit.edu	37	16	61687897	61687897	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr16:61687897C>T	uc002eog.1	-	12	2267	c.2015G>A	c.(2014-2016)GGA>GAA	p.G672E		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	672	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		CTCCTCCCCTCCTCCTTCATC	0.398			NA											36	169					0	0	0.007835	0	0
FUK	197258	broad.mit.edu	37	16	70497537	70497537	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr16:70497537C>T	uc002eyy.2	+	3	152	c.94C>T	c.(94-96)CGG>TGG	p.R32W	FUK_uc010vmb.1_Missense_Mutation_p.R32W|FUK_uc010cft.2_Missense_Mutation_p.R32W|FUK_uc002eyz.2_Intron	NM_145059	NP_659496	Q8N0W3	FUK_HUMAN	fucokinase	32						cytoplasm	ATP binding|fucokinase activity			ovary(1)	1		Ovarian(137;0.0694)				ACTGGAAGTGCGGCAGAAGCG	0.617			NA											4	151					0	0	0.000602	0	0
TP53	7157	broad.mit.edu	37	17	7578235	7578235	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr17:7578235T>C	uc002gim.2	-	6	808	c.614A>G	c.(613-615)TAT>TGT	p.Y205C	TP53_uc002gig.1_Missense_Mutation_p.Y205C|TP53_uc002gih.2_Missense_Mutation_p.Y205C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y73C|TP53_uc010cng.1_Missense_Mutation_p.Y73C|TP53_uc002gii.1_Missense_Mutation_p.Y73C|TP53_uc010cnh.1_Missense_Mutation_p.Y205C|TP53_uc010cni.1_Missense_Mutation_p.Y205C|TP53_uc002gij.2_Missense_Mutation_p.Y205C|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.Y112C|TP53_uc002gio.2_Missense_Mutation_p.Y73C|TP53_uc010vug.1_Missense_Mutation_p.Y166C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	205	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> N (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> C (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y205C(55)|p.Y205D(13)|p.Y205S(11)|p.Y205F(8)|p.0?(7)|p.Y205H(5)|p.Y205*(4)|p.Y205N(2)|p.K164_P219del(1)|p.Y205fs*42(1)|p.Y112C(1)|p.Y205fs*43(1)|p.E204fs*39(1)|p.Y73C(1)|p.E204_N210delEYLDDRN(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTCATCCAAATACTCCACACG	0.542	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			4	53					0	0	0.009096	0	0
ERBB2	2064	broad.mit.edu	37	17	37876038	37876038	+	Splice_Site	SNP	A	A	T	rs112734930		TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr17:37876038A>T	uc002hso.2	+	16	2137	c.1899_splice	c.e16-2	p.S633_splice	ERBB2_uc002hsm.2_Splice_Site_p.S603_splice|ERBB2_uc010cwa.2_Splice_Site_p.S618_splice|ERBB2_uc002hsp.2_Splice_Site_p.S436_splice|ERBB2_uc010cwb.2_Splice_Site_p.S633_splice|ERBB2_uc010wek.1_Splice_Site_p.S357_splice	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a						cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	TTTCTCCTGCAGCTGTGTGGA	0.473			1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			36	98					0	0	0.00623	0	0
IKZF3	22806	broad.mit.edu	37	17	37944531	37944531	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr17:37944531C>A	uc002hsu.2	-	6	751	c.689G>T	c.(688-690)AGC>ATC	p.S230I	IKZF3_uc002htd.2_Missense_Mutation_p.S196I|IKZF3_uc010cwd.2_Missense_Mutation_p.S87I|IKZF3_uc002hsv.2_Intron|IKZF3_uc010cwe.2_Intron|IKZF3_uc010cwf.2_Intron|IKZF3_uc010cwg.2_Intron|IKZF3_uc002hsw.2_Intron|IKZF3_uc002hsx.2_Missense_Mutation_p.S174I|IKZF3_uc002hsy.2_Missense_Mutation_p.S230I|IKZF3_uc002hsz.2_Intron|IKZF3_uc002hta.2_Intron|IKZF3_uc002htb.2_RNA|IKZF3_uc010cwh.2_Missense_Mutation_p.S143I|IKZF3_uc002htc.2_5'UTR	NM_012481	NP_036613	Q9UKT9	IKZF3_HUMAN	aiolos isoform 1	230					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)|kidney(2)|skin(2)	6	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TGGGTCAGTGCTCTGAAGAAA	0.318			NA											7	29					8.12818e-05	9.18629e-05	0.001984	1	0
KLHL11	55175	broad.mit.edu	37	17	40010662	40010662	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr17:40010662G>A	uc002hyf.1	-	2	1463	c.1457C>T	c.(1456-1458)TCG>TTG	p.S486L		NM_018143	NP_060613	Q9NVR0	KLH11_HUMAN	kelch-like 11 precursor	486	Kelch 3.					extracellular region					0		Breast(137;0.00156)				CTTTGGTGCCGATTCCAAGTT	0.458			NA											37	119					0	0	0.003755	0	0
NMT1	4836	broad.mit.edu	37	17	43175845	43175846	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr17:43175845_43175846GG>TT	uc002ihz.2	+	7	827_828	c.809_810GG>TT	c.(808-810)CGG>CTT	p.R270L	NMT1_uc002iia.2_RNA	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	270					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				ATCACCAGGCGGGTTCACCTGG	0.535			NA											32	118					0	0	0.004672	0	0
SFRS1	6426	broad.mit.edu	37	17	56083844	56083844	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr17:56083844T>C	uc002ivi.2	-	2	448	c.239A>G	c.(238-240)GAT>GGT	p.D80G	SFRS1_uc002ivj.2_Missense_Mutation_p.D80G	NM_006924	NP_008855	Q07955	SRSF1_HUMAN	splicing factor, arginine/serine-rich 1 isoform	80	RRM 1.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA 5'-splice site recognition|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytoplasm|nuclear speck	nucleotide binding|RNA binding				0		Colorectal(1115;0.0691)		LUAD - Lung adenocarcinoma(1115;0.247)		ACGGTACCCATCGTAATCATA	0.637			NA											4	31					0	0	0.000602	0	0
SAP30BP	29115	broad.mit.edu	37	17	73702103	73702103	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr17:73702103G>T	uc002jpe.2	+	10	730	c.676G>T	c.(676-678)GGC>TGC	p.G226C	SAP30BP_uc002jpc.1_RNA|SAP30BP_uc010wsf.1_RNA|SAP30BP_uc010wsg.1_RNA|SAP30BP_uc002jpf.2_Missense_Mutation_p.G210C	NM_013260	NP_037392	Q9UHR5	S30BP_HUMAN	transcriptional regulator protein	226	Thr-rich.				apoptosis|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1	all_cancers(13;6.42e-08)		all cancers(21;4.25e-07)|Epithelial(20;9.57e-07)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GTTTGTGACGGGCACCAAAAA	0.433			NA											7	31					2.0095e-06	2.38394e-06	0.001984	1	0
TXNDC2	84203	broad.mit.edu	37	18	9886910	9886910	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr18:9886910A>T	uc002koi.3	+	2	883	c.434A>T	c.(433-435)AAA>ATA	p.K145I	TXNDC2_uc010wzq.1_RNA|TXNDC2_uc002koh.3_Missense_Mutation_p.K78I	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	145	3.|22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						ATCCAGCCCAAAGAGAGTAAC	0.562			NA											39	99					0	0	0.004878	0	0
DSC2	1824	broad.mit.edu	37	18	28650692	28650692	+	Silent	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr18:28650692C>A	uc002kwl.3	-	14	2704	c.2250G>T	c.(2248-2250)GTG>GTT	p.V750V	DSC2_uc002kwk.3_Silent_p.V750V	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	750	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GACTACTTACCACTTTGTCAT	0.368			NA											16	48					5.01169e-05	5.69782e-05	0.00499	1	0
CELF4	56853	broad.mit.edu	37	18	34853003	34853003	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr18:34853003C>G	uc002lae.2	-	7	1321	c.925G>C	c.(925-927)GCC>CCC	p.A309P	CELF4_uc010dnd.1_Missense_Mutation_p.A307P|CELF4_uc002lag.2_Missense_Mutation_p.A299P|CELF4_uc002laf.2_Missense_Mutation_p.A304P|CELF4_uc002lai.2_Missense_Mutation_p.A294P|CELF4_uc002lah.1_Missense_Mutation_p.A34P|CELF4_uc002laj.1_Missense_Mutation_p.G144A	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	309	Ala-rich.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						ATAGGTGCGGCCGCCAGGCCA	0.657			NA											4	50					0	0	0.009096	0	0
GALR1	2587	broad.mit.edu	37	18	74980579	74980579	+	Silent	SNP	A	A	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr18:74980579A>G	uc002lms.3	+	3	1268	c.771A>G	c.(769-771)GGA>GGG	p.G257G		NM_001480	NP_001471	P47211	GALR1_HUMAN	galanin receptor 1	257	Helical; Name=6; (Potential).				digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			lung(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		TGGTGTTTGGAATCTCCTGGC	0.403			NA											26	170					0	0	0.012213	0	0
GALR1	2587	broad.mit.edu	37	18	74980858	74980858	+	Nonstop_Mutation	SNP	A	A	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr18:74980858A>C	uc002lms.3	+	3	1547	c.1050A>C	c.(1048-1050)TGA>TGC	p.*350C		NM_001480	NP_001471	P47211	GALR1_HUMAN	galanin receptor 1	350					digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			lung(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		CTCATGTGTGATAAAAGATAG	0.383			NA											8	114					0	0	0.004482	0	0
XAB2	56949	broad.mit.edu	37	19	7687539	7687539	+	Silent	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr19:7687539C>A	uc002mgx.2	-	11	1406	c.1380G>T	c.(1378-1380)ACG>ACT	p.T460T		NM_020196	NP_064581	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	460					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			central_nervous_system(2)|breast(1)|skin(1)	4						CAGGCAGCGCCGTGGCCTTCT	0.682			NA						Direct_reversal_of_damage|NER					19	50					2.4624e-09	3.0942e-09	0.008871	1	0
KEAP1	9817	broad.mit.edu	37	19	10600006	10600006	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr19:10600006C>A	uc002moq.1	-	5	1726	c.1570G>T	c.(1570-1572)GGC>TGC	p.G524C	KEAP1_uc002mop.1_Intron|KEAP1_uc002mor.1_Missense_Mutation_p.G524C	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	524	Kelch 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding	p.G524C(1)		lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CCATCATAGCCCCCAGCAGCA	0.582			NA											11	24					0.000978159	0.00107993	0.010729	1	0
CARM1	10498	broad.mit.edu	37	19	11022906	11022906	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr19:11022906C>T	uc002mpz.2	+	5	731	c.605C>T	c.(604-606)GCC>GTC	p.A202V	CARM1_uc010dxn.2_RNA|CARM1_uc002mqa.2_5'UTR	NM_199141	NP_954592	Q86X55	CARM1_HUMAN	coactivator-associated arginine	202					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding				0						TCGTTTTTTGCCGCCCAAGCT	0.622			NA											5	267					0	0	0.001168	0	0
CD22	933	broad.mit.edu	37	19	35829190	35829190	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr19:35829190A>C	uc010edt.2	+	6	1182	c.1105A>C	c.(1105-1107)AAT>CAT	p.N369H	CD22_uc010xst.1_Missense_Mutation_p.N197H|CD22_uc010edu.2_Intron|CD22_uc010edv.2_Missense_Mutation_p.N369H|CD22_uc002nzb.3_Intron|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	369	Extracellular (Potential).|Ig-like C2-type 3.				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	GTGGTACCACAATGGGAAAGA	0.502	Ovarian(42;1009 1133 23674 26041)		NA											25	79					0	0	0.005443	0	0
HNRNPUL1	11100	broad.mit.edu	37	19	41807447	41807447	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr19:41807447G>T	uc002oqb.3	+	11	1814	c.1525G>T	c.(1525-1527)GTT>TTT	p.V509F	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Missense_Mutation_p.V409F|HNRNPUL1_uc002oqa.3_Missense_Mutation_p.V409F|HNRNPUL1_uc010ehm.2_Missense_Mutation_p.V509F|HNRNPUL1_uc002oqc.3_Missense_Mutation_p.V395F|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Missense_Mutation_p.V409F|HNRNPUL1_uc010ehn.2_Missense_Mutation_p.V409F|HNRNPUL1_uc010eho.2_Missense_Mutation_p.V409F|HNRNPUL1_uc010xvy.1_Missense_Mutation_p.V409F|HNRNPUL1_uc010ehp.2_Missense_Mutation_p.V365F|HNRNPUL1_uc002oqf.3_5'Flank	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	509	Necessary for interaction with TP53.|Necessary for interaction with BRD7 and transcriptional activation.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						TTAGACAAATGTTTATGGGTC	0.443			NA											36	120					6.53348e-20	9.6736e-20	0.003755	1	0
ZNF285	26974	broad.mit.edu	37	19	44896581	44896581	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr19:44896581A>T	uc002ozd.3	-	3	152	c.65T>A	c.(64-66)CTG>CAG	p.L22Q	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Missense_Mutation_p.L29Q	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	22	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						CAATAGTGCCAGCTCTTCCTT	0.438			NA											35	108					0	0	0.003271	0	0
NLRP7	199713	broad.mit.edu	37	19	55445884	55445884	+	Missense_Mutation	SNP	C	C	A	rs150034626	byFrequency	TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr19:55445884C>A	uc002qih.3	-	7	2520	c.2444G>T	c.(2443-2445)CGC>CTC	p.R815L	NLRP7_uc002qig.3_Missense_Mutation_p.R787L|NLRP7_uc002qii.3_Missense_Mutation_p.R815L|NLRP7_uc010esk.2_Missense_Mutation_p.R815L|NLRP7_uc010esl.2_Missense_Mutation_p.R843L	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	815							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		GTGTTTTGGGCGTGTCATGGT	0.512			NA											28	97					6.07407e-21	9.06366e-21	0.007291	1	0
TNNI3	7137	broad.mit.edu	37	19	55666180	55666180	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr19:55666180G>A	uc002qjg.3	-	6	301	c.301C>T	c.(301-303)CAC>TAC	p.H101Y	TNNI3_uc010yft.1_Missense_Mutation_p.H93Y	NM_000363	NP_000354	P19429	TNNI3_HUMAN	troponin I, cardiac	101					cardiac muscle contraction|cellular calcium ion homeostasis|muscle filament sliding|negative regulation of ATPase activity|regulation of systemic arterial blood pressure by ischemic conditions|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|calcium channel inhibitor activity|calcium-dependent protein binding|protein domain specific binding|protein kinase binding|troponin C binding|troponin T binding			lung(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		ACACGGGCGTGGAGCTGTCGG	0.453			NA											10	28					0	0	0.006214	0	0
ZFP28	140612	broad.mit.edu	37	19	57066566	57066566	+	Silent	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr19:57066566G>A	uc002qnj.2	+	8	2483	c.2412G>A	c.(2410-2412)AAG>AAA	p.K804K	uc002qnk.1_Intron	NM_020828	NP_065879	Q8NHY6	ZFP28_HUMAN	zinc finger protein 28	804	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		ATCAACATAAGAGAGTTCATA	0.378	Ovarian(124;554 1662 19430 21141 52494)		NA											4	140					0	0	0.009096	0	0
SLC30A6	55676	broad.mit.edu	37	2	32422894	32422894	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr2:32422894A>G	uc002roe.1	+	10	701	c.664A>G	c.(664-666)AAT>GAT	p.N222D	SLC30A6_uc002rof.1_Missense_Mutation_p.N262D|SLC30A6_uc010ymw.1_Missense_Mutation_p.N193D|SLC30A6_uc010ezr.1_Missense_Mutation_p.N222D|SLC30A6_uc002rog.1_Missense_Mutation_p.N25D|SLC30A6_uc010ezs.1_Missense_Mutation_p.N148D|SLC30A6_uc002roh.1_Missense_Mutation_p.N25D	NM_017964	NP_060434	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter),	222	Extracellular (Potential).					Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CATTGAAATTAAGTGAGTATT	0.264			NA											17	55					0	0	0.006122	0	0
MYO7B	4648	broad.mit.edu	37	2	128347795	128347795	+	Silent	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr2:128347795G>A	uc002top.2	+	16	2036	c.1983G>A	c.(1981-1983)AAG>AAA	p.K661K		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	661	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		ATGAGTACAAGAAGCCGCTGG	0.552			NA											9	33					0	0	0.010729	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802719	185802719	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr2:185802719G>T	uc002uph.2	+	4	3190	c.2596G>T	c.(2596-2598)GAA>TAA	p.E866*		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	866						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TGCAAAAATCGAAAGGAACTC	0.353			NA											22	64					2.89027e-11	3.88761e-11	0.014323	1	0
FAM117B	150864	broad.mit.edu	37	2	203630353	203630353	+	Silent	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr2:203630353C>T	uc010zhx.1	+	8	1646	c.1636C>T	c.(1636-1638)CTG>TTG	p.L546L		NM_173511	NP_775782	Q6P1L5	F117B_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	546										ovary(1)	1						GACAACCACTCTGCTGCAGCC	0.557			NA											19	73					0	0	0.008871	0	0
TNP1	7141	broad.mit.edu	37	2	217724644	217724644	+	Silent	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr2:217724644C>T	uc002vgk.2	-	1	139	c.114G>A	c.(112-114)CTG>CTA	p.L38L		NM_003284	NP_003275	P09430	STP1_HUMAN	transition protein 1 (during histone to	38					chromatin silencing|fertilization, exchange of chromosomal proteins|multicellular organismal development|nucleosome disassembly|single strand break repair|sperm motility|spermatid nucleus elongation	nucleosome	DNA binding				0		Renal(207;0.0822)		Epithelial(149;8.97e-07)|all cancers(144;2.46e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCTACTTTTCAGGTTGCCCT	0.532			NA											25	125					0	0	0.005443	0	0
TNS1	7145	broad.mit.edu	37	2	218669198	218669198	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr2:218669198G>A	uc002vgt.2	-	33	5590	c.5192C>T	c.(5191-5193)GCC>GTC	p.A1731V	TNS1_uc002vgr.2_Missense_Mutation_p.A1717V|TNS1_uc002vgs.2_Missense_Mutation_p.A1710V|TNS1_uc002vgq.2_Missense_Mutation_p.A231V	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	1731						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		CTTTTGGCCGGCATTCAGCAT	0.612			NA											4	124					0	0	0.000602	0	0
CCDC108	255101	broad.mit.edu	37	2	219873855	219873855	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr2:219873855T>A	uc002vjl.1	-	29	4672	c.4588A>T	c.(4588-4590)AGG>TGG	p.R1530W		NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	1530	Potential.					integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGATACTGCCTCATGAGCTGC	0.582			NA											11	32					0	0	0.001855	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871865	51871865	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr20:51871865C>A	uc002xwo.2	+	2	2824	c.1868C>A	c.(1867-1869)GCC>GAC	p.A623D		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	623					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			CACGAAGAGGCCTCATCTTTC	0.522			NA											24	110					4.4004e-07	5.31947e-07	0.00333	1	0
CTSZ	1522	broad.mit.edu	37	20	57576645	57576645	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr20:57576645T>A	uc002yai.2	-	3	488	c.362A>T	c.(361-363)CAG>CTG	p.Q121L	CTSZ_uc002yaj.3_Missense_Mutation_p.Q121L	NM_001336	NP_001327	Q9UBR2	CATZ_HUMAN	cathepsin Z preproprotein	121					proteolysis	endoplasmic reticulum|extracellular space|lysosome	cysteine-type endopeptidase activity			kidney(1)	1	all_lung(29;0.00711)		Colorectal(105;0.109)			GATGACGTTCTGCACGGACAG	0.612			NA											20	47					0	0	0.008871	0	0
CHRNA4	1137	broad.mit.edu	37	20	61982143	61982144	+	Missense_Mutation	DNP	CC	CC	TT			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr20:61982143_61982144CC>TT	uc002yes.2	-	5	797_798	c.619_620GG>AA	c.(619-621)GGC>AAC	p.G207N	CHRNA4_uc002yet.1_Missense_Mutation_p.G31N|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Missense_Mutation_p.G136N|CHRNA4_uc002yev.1_Missense_Mutation_p.G31N|CHRNA4_uc010gkf.1_Missense_Mutation_p.G31N	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	207	Extracellular (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	GACCCACTCGCCACTCTCCCAG	0.584			NA											13	46					0	0	0.004672	0	0
SAMSN1	64092	broad.mit.edu	37	21	15889331	15889331	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr21:15889331C>A	uc002yju.1	-	3	243	c.161G>T	c.(160-162)GGA>GTA	p.G54V	SAMSN1_uc010gky.1_Intron|SAMSN1_uc002yjv.1_Missense_Mutation_p.G122V	NM_022136	NP_071419	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization	54					negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding	p.G54E(1)		ovary(3)|pancreas(1)	4				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		ACTTTGTTCTCCACTTCCATT	0.318			NA											6	34					3.59834e-05	4.11546e-05	0.001168	1	0
LSS	4047	broad.mit.edu	37	21	47642572	47642573	+	Missense_Mutation	DNP	CT	CT	AA			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr21:47642572_47642573CT>AA	uc002zij.2	-	4	478_479	c.399_400AG>TT	c.(397-402)TCAGTG>TCTTTG	p.V134L	LSS_uc011afv.1_Intron|LSS_uc002zil.2_Missense_Mutation_p.V134L|LSS_uc002zik.2_Missense_Mutation_p.V54L	NM_001001438	NP_001001438	P48449	ERG7_HUMAN	lanosterol synthase isoform 1	134	PFTB 1.				cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity				0	Breast(49;0.214)					GGGAGCTGCACTGACCGCAGGT	0.584	Pancreas(114;955 2313 34923 50507)		NA											4	38					0	0	0.004672	0	0
PNPLA3	80339	broad.mit.edu	37	22	44328953	44328953	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr22:44328953C>T	uc003bei.1	+	4	855	c.682C>T	c.(682-684)CCC>TCC	p.P228S	PNPLA3_uc010gzm.1_RNA	NM_025225	NP_079501	Q9NST1	PLPL3_HUMAN	patatin-like phospholipase domain containing 3	228	Lumenal (Potential).				triglyceride biosynthetic process|triglyceride catabolic process	integral to membrane	diolein transacylation activity|mono-olein transacylation activity|phospholipase A2 activity|triglyceride lipase activity				0		Ovarian(80;0.024)|all_neural(38;0.0416)				AGCTTTTGTCCCCCCGGATCT	0.547			NA											38	86					0	0	0.009718	0	0
NUP50	10762	broad.mit.edu	37	22	45574368	45574368	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr22:45574368T>C	uc003bfr.2	+	5	1052	c.590T>C	c.(589-591)ATT>ACT	p.I197T	NUP50_uc003bfs.2_Missense_Mutation_p.I169T|NUP50_uc011aqn.1_5'UTR|NUP50_uc003bft.2_Missense_Mutation_p.I169T|NUP50_uc011aqo.1_5'UTR	NM_007172	NP_009103	Q9UKX7	NUP50_HUMAN	nucleoporin 50kDa isoform b	197	5 X 2 AA repeats of F-G.|Binding to CDKN1B (By similarity).				carbohydrate metabolic process|glucose transport|intracellular transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore|nucleoplasm	protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		TTAGCAAACATTGAACAGCAA	0.423			NA											4	108					0	0	0.009096	0	0
ALG12	79087	broad.mit.edu	37	22	50302947	50302947	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr22:50302947G>A	uc003biy.2	-	6	987	c.713C>T	c.(712-714)CCG>CTG	p.P238L		NM_024105	NP_077010	Q9BV10	ALG12_HUMAN	alpha-1,6-mannosyltransferase ALG12	238					dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane					0		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		BRCA - Breast invasive adenocarcinoma(115;0.199)|LUAD - Lung adenocarcinoma(64;0.247)		CTTTCCTTCCGGCCAAGTGAG	0.502			NA											4	87					0	0	0.009096	0	0
CHKB	1120	broad.mit.edu	37	22	51020255	51020255	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr22:51020255C>A	uc003bms.2	-	3	588	c.370G>T	c.(370-372)GCC>TCC	p.A124S	CHKB-CPT1B_uc003bmp.2_5'Flank|CHKB-CPT1B_uc003bmt.1_Intron|CHKB-CPT1B_uc003bmu.2_Missense_Mutation_p.A3S|CHKB_uc003bmv.2_Missense_Mutation_p.A124S|LOC100144603_uc003bmw.3_5'Flank	NM_005198	NP_005189	Q9Y259	CHKB_HUMAN	choline kinase beta	124					phosphatidylethanolamine biosynthetic process		ATP binding|choline kinase activity|ethanolamine kinase activity				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;4.04e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.79e-74)|Epithelial(4;6.17e-70)|GBM - Glioblastoma multiforme(4;5.68e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.205)	Choline(DB00122)	GCAAGTATGGCGAACATCACG	0.612			NA											20	65					5.26018e-13	7.28039e-13	0.012319	1	0
CHKB	1120	broad.mit.edu	37	22	51021107	51021107	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr22:51021107C>T	uc003bms.2	-	1	322	c.104G>A	c.(103-105)CGG>CAG	p.R35Q	CHKB-CPT1B_uc003bmt.1_5'UTR|CHKB-CPT1B_uc003bmu.2_5'UTR|CHKB_uc003bmv.2_Missense_Mutation_p.R35Q|LOC100144603_uc003bmw.3_5'Flank	NM_005198	NP_005189	Q9Y259	CHKB_HUMAN	choline kinase beta	35					phosphatidylethanolamine biosynthetic process		ATP binding|choline kinase activity|ethanolamine kinase activity				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;4.04e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.79e-74)|Epithelial(4;6.17e-70)|GBM - Glioblastoma multiforme(4;5.68e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.205)	Choline(DB00122)	GGCGCGCCGCCGTTTTGGGGT	0.711			NA											5	10					0	0	0.000602	0	0
PPARG	5468	broad.mit.edu	37	3	12458450	12458450	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr3:12458450C>A	uc003bwx.2	+	6	1158	c.1067C>A	c.(1066-1068)ACA>AAA	p.T356K	PPARG_uc003bwr.2_Missense_Mutation_p.T328K|PPARG_uc003bws.2_Missense_Mutation_p.T328K|PPARG_uc003bwu.2_Missense_Mutation_p.T328K|PPARG_uc003bwv.2_Intron|PPARG_uc010hea.1_RNA	NM_015869	NP_056953	P37231	PPARG_HUMAN	peroxisome proliferative activated receptor	356	Ligand-binding.				activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|kidney(1)	2					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	ATCATTTACACAATGCTGGCC	0.443			NA	T	PAX8	follicular thyroid		Insulin resistance ; lipodystrophy|familial partial L;diabetes mellitus|insulin-resistantI|with acanthosis nigricans and hypertension						9	45					0.00621372	0.00659344	0.006214	1	0
CTNNB1	1499	broad.mit.edu	37	3	41280817	41280817	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr3:41280817T>C	uc010hia.1	+	16	2486	c.2330T>C	c.(2329-2331)TTT>TCT	p.F777S	CTNNB1_uc003ckp.2_Missense_Mutation_p.F777S|CTNNB1_uc003ckq.2_Missense_Mutation_p.F777S|CTNNB1_uc003ckr.2_Missense_Mutation_p.F777S|CTNNB1_uc011azf.1_Missense_Mutation_p.F770S|CTNNB1_uc011azg.1_Missense_Mutation_p.F705S	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	777	Interaction with SCRIB (By similarity).				adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding		CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	CTGGCCTGGTTTGATACTGAC	0.478	Colon(6;3 56 14213 18255)		15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				8	31					0	0	0.00308	0	0
ARGFX	503582	broad.mit.edu	37	3	121305205	121305205	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr3:121305205C>A	uc003eef.2	+	5	801	c.706C>A	c.(706-708)CTT>ATT	p.L236I		NM_001012659	NP_001012677	A6NJG6	ARGFX_HUMAN	arginine-fifty homeobox	236						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(114;0.152)		ACTGTACAATCTTCCTGATGA	0.463			NA											28	102					4.7796e-09	5.92795e-09	0.004656	1	0
TRPC1	7220	broad.mit.edu	37	3	142496497	142496497	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr3:142496497G>A	uc003evc.2	+	5	792	c.656G>A	c.(655-657)TGT>TAT	p.C219Y	TRPC1_uc003evb.2_Missense_Mutation_p.C185Y	NM_003304	NP_003295	P48995	TRPC1_HUMAN	transient receptor potential cation channel,	219	Cytoplasmic (Potential).				axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						ATATATCGATGTTTGGCCAGT	0.303			NA											16	48					0	0	0.006122	0	0
LRRC33	375387	broad.mit.edu	37	3	196386667	196386667	+	Silent	SNP	G	G	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr3:196386667G>T	uc003fwv.2	+	3	257	c.153G>T	c.(151-153)GTG>GTT	p.V51V		NM_198565	NP_940967	Q86YC3	LRC33_HUMAN	leucine rich repeat containing 33 precursor	51	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.9e-23)|all cancers(36;1.76e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		TCGCTTCGGTGCCCAGCAGCC	0.652			NA											7	24					2.0095e-06	2.38394e-06	0.001984	1	0
PDGFRA	5156	broad.mit.edu	37	4	55156542	55156542	+	Silent	SNP	T	T	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr4:55156542T>A	uc003han.3	+	22	3274	c.2943T>A	c.(2941-2943)CGT>CGA	p.R981R	PDGFRA_uc003haa.2_Silent_p.R741R	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	981	Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CACGCATGCGTGTGGACTCAG	0.448	Pancreas(151;208 1913 7310 23853 37092)		NA	Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			24	76					0	0	0.00333	0	0
KDR	3791	broad.mit.edu	37	4	55968660	55968660	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr4:55968660G>T	uc003has.2	-	14	2305	c.2003C>A	c.(2002-2004)ACG>AAG	p.T668K	KDR_uc003hat.1_Missense_Mutation_p.T668K	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	668	Ig-like C2-type 7.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TCCTGTGATCGTGGGTGCCAC	0.428			NA	Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			16	56					1.56452e-12	2.14981e-12	0.007413	1	0
SHROOM3	57619	broad.mit.edu	37	4	77675651	77675651	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr4:77675651A>T	uc011cbx.1	+	7	4968	c.4015A>T	c.(4015-4017)ACG>TCG	p.T1339S	SHROOM3_uc003hkg.2_Missense_Mutation_p.T1117S	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1339					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			ACTGGCAGGAACGCAAGGGCT	0.607			NA											17	79					0	0	0.006122	0	0
QRFPR	84109	broad.mit.edu	37	4	122261661	122261661	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr4:122261661G>T	uc010inj.1	-	2	824	c.445C>A	c.(445-447)CAT>AAT	p.H149N	QRFPR_uc010ink.1_RNA|QRFPR_uc003ids.2_Missense_Mutation_p.H149N|QRFPR_uc010inl.1_Missense_Mutation_p.H149N	NM_198179	NP_937822	Q96P65	QRFPR_HUMAN	G protein-coupled receptor 103	149	Cytoplasmic (Potential).					plasma membrane	neuropeptide Y receptor activity				0						TTAAAAGGATGCACAAGTCCC	0.468			NA											11	38					4.36969e-10	5.71651e-10	0.001855	1	0
BBS7	55212	broad.mit.edu	37	4	122774156	122774156	+	Silent	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr4:122774156C>T	uc003ied.2	-	8	978	c.804G>A	c.(802-804)GTG>GTA	p.V268V	BBS7_uc003iee.1_Silent_p.V268V	NM_176824	NP_789794	Q8IWZ6	BBS7_HUMAN	Bardet-Biedl syndrome 7 protein isoform a	268					cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			ovary(1)	1						CAAAACTATACACTTCCACCA	0.318			NA							Bardet-Biedl_syndrome				9	20					0	0	0.004482	0	0
CYP4V2	285440	broad.mit.edu	37	4	187130126	187130126	+	Missense_Mutation	SNP	C	C	T	rs138444697		TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr4:187130126C>T	uc003iyw.3	+	9	1502	c.1198C>T	c.(1198-1200)CGT>TGT	p.R400C	CYP4V2_uc010ism.2_RNA	NM_207352	NP_997235	Q6ZWL3	CP4V2_HUMAN	cytochrome P450, family 4, subfamily v,	400					response to stimulus|visual perception	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.33e-10)|BRCA - Breast invasive adenocarcinoma(30;3.84e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000293)|LUSC - Lung squamous cell carcinoma(40;0.00242)|READ - Rectum adenocarcinoma(43;0.17)		TTTATTTGCCCGTAGTGTTAG	0.433			NA											13	119					0	0	0.00245	0	0
BRD9	65980	broad.mit.edu	37	5	865601	865602	+	Missense_Mutation	DNP	GC	GC	AA			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr5:865601_865602GC>AA	uc003jbq.2	-	15	1787_1788	c.1620_1621GC>TT	c.(1618-1623)GAGCGC>GATTGC	p.540_541ER>DC	BRD9_uc003jbl.2_Missense_Mutation_p.424_425ER>DC|BRD9_uc003jbm.2_RNA|BRD9_uc003jbn.2_RNA|BRD9_uc011cmb.1_Missense_Mutation_p.487_488ER>DC|BRD9_uc003jbo.2_Missense_Mutation_p.444_445ER>DC	NM_023924	NP_076413	Q9H8M2	BRD9_HUMAN	bromodomain containing 9 isoform 1	540_541							nucleic acid binding				0			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			GAGCCGCCGCGCTCCGCCTGTG	0.644			NA											29	119					0	0	0.004672	0	0
PDZD2	23037	broad.mit.edu	37	5	32074612	32074612	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr5:32074612G>A	uc003jhl.2	+	18	3788	c.3400G>A	c.(3400-3402)GAG>AAG	p.E1134K	PDZD2_uc003jhm.2_Missense_Mutation_p.E1134K|PDZD2_uc011cnx.1_Missense_Mutation_p.E960K	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1134					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						ATCCGAGGCTGAGGCCAAGCC	0.602			NA											7	41					0	0	0.001984	0	0
ISL1	3670	broad.mit.edu	37	5	50683340	50683340	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr5:50683340T>A	uc003jor.2	+	3	783	c.235T>A	c.(235-237)TGC>AGC	p.C79S		NM_002202	NP_002193	P61371	ISL1_HUMAN	islet-1	79	LIM zinc-binding 2.				generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3		Lung NSC(810;0.000845)|Breast(144;0.0411)				CGGGATCAAATGCGCCAAGTG	0.627			NA											6	12					0	0	0.001168	0	0
GLRX	2745	broad.mit.edu	37	5	95152247	95152247	+	Silent	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr5:95152247C>A	uc003klo.3	-	2	502	c.291G>T	c.(289-291)ACG>ACT	p.T97T	GLRX_uc003kln.3_Silent_p.T97T	NM_001118890	NP_001112362	P35754	GLRX1_HUMAN	glutaredoxin (thioltransferase)	97	Glutaredoxin.				cell redox homeostasis|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|transport	cytosol	electron carrier activity|glutathione disulfide oxidoreductase activity|protein disulfide oxidoreductase activity|protein N-terminus binding				0		all_cancers(142;3.38e-06)|all_epithelial(76;5.66e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;2.62e-16)	Glutathione(DB00143)	GCTTTAGCCGCGTCAGCAGTT	0.512			NA											21	46					2.89027e-11	3.88761e-11	0.014323	1	0
PCDHGA6	56109	broad.mit.edu	37	5	140755360	140755360	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr5:140755360C>A	uc003ljy.1	+	1	1710	c.1710C>A	c.(1708-1710)GAC>GAA	p.D570E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.D570E	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	570	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCCCACAGACGGTTCCACTG	0.667			NA											39	148					8.69298e-16	1.25785e-15	0.006999	1	0
SLC36A2	153201	broad.mit.edu	37	5	150722498	150722498	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr5:150722498G>T	uc003lty.2	-	4	521	c.391C>A	c.(391-393)CTA>ATA	p.L131I	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_5'UTR|SLC36A2_uc010jhv.2_Missense_Mutation_p.L131I|SLC36A2_uc011dct.1_Missense_Mutation_p.L131I	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	131	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTGGCTTCTAGTCCATGCATC	0.512			NA											17	54					5.3912e-06	6.3563e-06	0.006122	1	0
GPRIN1	114787	broad.mit.edu	37	5	176023823	176023823	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr5:176023823G>T	uc003meo.1	-	2	3188	c.3013C>A	c.(3013-3015)CCC>ACC	p.P1005T		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	1005	Interaction with GNAO1 (By similarity).					growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCGGCCGTGGGTCCCGCCCGC	0.706			NA											4	17					0.00024832	0.000278995	0.009096	1	0
SQSTM1	8878	broad.mit.edu	37	5	179260106	179260106	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr5:179260106A>G	uc003mkw.3	+	6	924	c.829A>G	c.(829-831)AGC>GGC	p.S277G	SQSTM1_uc011dgr.1_Missense_Mutation_p.S193G|SQSTM1_uc011dgs.1_Missense_Mutation_p.S193G|SQSTM1_uc003mkv.3_Missense_Mutation_p.S277G|SQSTM1_uc003mkx.2_Missense_Mutation_p.S193G	NM_003900	NP_003891	Q13501	SQSTM_HUMAN	sequestosome 1 isoform 1	277	Interaction with NTRK1 (By similarity).|Ser-rich.				anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGAGAGTTCCAGCACAGAGGA	0.597			NA							Paget_Disease_of_Bone				13	53					0	0	0.003163	0	0
HIST1H2BJ	8970	broad.mit.edu	37	6	27100390	27100390	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr6:27100390T>G	uc003niv.2	-	1	186	c.140A>C	c.(139-141)AAG>ACG	p.K47T	HIST1H2BJ_uc003niu.1_RNA|HIST1H2AG_uc003niw.2_5'Flank	NM_021058	NP_066402	P06899	H2B1J_HUMAN	histone cluster 1, H2bj	47					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0						GTGGACCTGCTTCAGAACCTT	0.552			NA											5	260					0	0	0.001168	0	0
SKIV2L	6499	broad.mit.edu	37	6	31930285	31930285	+	Silent	SNP	G	G	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr6:31930285G>C	uc003nyn.1	+	11	1523	c.1134G>C	c.(1132-1134)GGG>GGC	p.G378G	SKIV2L_uc011dou.1_Silent_p.G220G|SKIV2L_uc011dov.1_Silent_p.G185G	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	378	Helicase ATP-binding.					nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						ACACATTCGGGGATGTGGGGC	0.562			NA											10	45					0	0	0.010729	0	0
CUL7	9820	broad.mit.edu	37	6	43017790	43017790	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr6:43017790A>G	uc003otq.2	-	6	1783	c.1480T>C	c.(1480-1482)TGG>CGG	p.W494R	CUL7_uc011dvb.1_Missense_Mutation_p.W578R|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	494					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			AGTTCCCACCACTCAGCCAGG	0.562			NA											34	91					0	0	0.003755	0	0
DST	667	broad.mit.edu	37	6	56418066	56418066	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr6:56418066A>G	uc003pdf.2	-	55	9195	c.9167T>C	c.(9166-9168)GTA>GCA	p.V3056A	DST_uc003pcz.3_Missense_Mutation_p.V2878A|DST_uc011dxj.1_Missense_Mutation_p.V2907A|DST_uc011dxk.1_Missense_Mutation_p.V2918A|DST_uc003pcy.3_Missense_Mutation_p.V2552A	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	4964					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GAGAGTCTCTACTTGCTCTTT	0.358			NA											17	213					0	0	0.008871	0	0
FAM46A	55603	broad.mit.edu	37	6	82461603	82461603	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr6:82461603C>G	uc003pjg.2	-	2	574	c.256G>C	c.(256-258)GGG>CGG	p.G86R	FAM46A_uc003pjf.2_Missense_Mutation_p.G105R|FAM46A_uc003pjh.1_Missense_Mutation_p.G86R	NM_017633	NP_060103	Q96IP4	FA46A_HUMAN	hypothetical protein LOC55603	86											0		all_cancers(76;6.74e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000282)|all_epithelial(107;0.0104)		BRCA - Breast invasive adenocarcinoma(397;0.0428)		TTGCCGCGCCCGTGAATCGGA	0.652			NA											6	70					0	0	0.00308	0	0
GRIK2	2898	broad.mit.edu	37	6	102250223	102250223	+	Silent	SNP	C	C	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr6:102250223C>G	uc003pqp.3	+	8	1362	c.1113C>G	c.(1111-1113)CTC>CTG	p.L371L	GRIK2_uc003pqn.2_Silent_p.L371L|GRIK2_uc003pqo.3_Silent_p.L371L|GRIK2_uc010kcw.2_Silent_p.L371L	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	371	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GGGAAGGCCTCACAGGCAGAA	0.338			NA											5	9					0	0	0.001168	0	0
ECT2L	345930	broad.mit.edu	37	6	139135693	139135693	+	Silent	SNP	A	A	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr6:139135693A>G	uc003qif.1	+	2	235	c.132A>G	c.(130-132)CAA>CAG	p.Q44Q	ECT2L_uc011edq.1_5'UTR	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	44					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						AGCAACGTCAAGAATTCTTAT	0.358			NA											5	45					0	0	0.001168	0	0
ZNF804B	219578	broad.mit.edu	37	7	88964342	88964342	+	Silent	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr7:88964342C>A	uc011khi.1	+	4	2584	c.2046C>A	c.(2044-2046)ATC>ATA	p.I682I		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	682						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GTAACCACATCAGCATGACCA	0.433			NA								HNSCC(36;0.09)			14	45					6.72482e-11	8.98211e-11	0.003163	1	0
ZAN	7455	broad.mit.edu	37	7	100349509	100349509	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr7:100349509C>A	uc003uwj.2	+	14	1946	c.1781C>A	c.(1780-1782)CCC>CAC	p.P594H	ZAN_uc003uwk.2_Missense_Mutation_p.P594H|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	594	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCCACCATTCCCACAGAAAAA	0.468			NA											14	51					7.93312e-07	9.52972e-07	0.00245	1	0
SMO	6608	broad.mit.edu	37	7	128846405	128846405	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr7:128846405T>C	uc003vor.2	+	6	1521	c.1241T>C	c.(1240-1242)GTG>GCG	p.V414A	SMO_uc003vos.2_Missense_Mutation_p.V89A	NM_005631	NP_005622	Q99835	SMO_HUMAN	smoothened precursor	414	Helical; Name=5; (Potential).				adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(19)|large_intestine(10)|central_nervous_system(3)|upper_aerodigestive_tract(2)|biliary_tract(1)|lung(1)|liver(1)	37						GTGCTCATCGTGGGAGGCTAC	0.572			NA	Mis		skin basal cell 								47	179					0	0	0.01441	0	0
PLXNA4	91584	broad.mit.edu	37	7	131887475	131887475	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr7:131887475G>T	uc003vra.3	-	12	2745	c.2516C>A	c.(2515-2517)CCT>CAT	p.P839H		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	839	PSI 3.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CTCCTGGGCAGGGCAGTGCTG	0.657			NA											9	33					0.000442599	0.000491491	0.006214	1	0
CLCN1	1180	broad.mit.edu	37	7	143029825	143029825	+	Silent	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr7:143029825C>A	uc003wcr.1	+	12	1347	c.1260C>A	c.(1258-1260)CCC>CCA	p.P420P	CLCN1_uc011ktc.1_Intron	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	420					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					AGTTGATGCCCCGCGAAGCCA	0.522			NA											56	206					4.83215e-14	6.78632e-14	0.01441	1	0
SSPO	23145	broad.mit.edu	37	7	149480000	149480000	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr7:149480000C>T	uc010lpk.2	+	15	1966	c.1966C>T	c.(1966-1968)CGC>TGC	p.R656C	SSPO_uc010lpl.1_Intron	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	656	VWFD 2.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCTCAGTGTGCGCCGAGCTTC	0.662			NA											5	34					0	0	0.001168	0	0
MLL3	58508	broad.mit.edu	37	7	151962175	151962175	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr7:151962175A>C	uc003wla.2	-	8	1351	c.1132T>G	c.(1132-1134)TTA>GTA	p.L378V		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	378	PHD-type 1.|RING-type.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GCACGTTTTAATGGAGTAACC	0.453	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								8	311					0	0	0.004007	0	0
RP1L1	94137	broad.mit.edu	37	8	10465434	10465434	+	Silent	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr8:10465434C>T	uc003wtc.2	-	4	6403	c.6174G>A	c.(6172-6174)CCG>CCA	p.P2058P		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	2058					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CTTCTGCCTCCGGGGCCTCTA	0.617			NA											59	183					0	0	0.01441	0	0
ZFHX4	79776	broad.mit.edu	37	8	77763345	77763345	+	Silent	SNP	G	G	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr8:77763345G>A	uc003yav.2	+	10	4440	c.4053G>A	c.(4051-4053)AAG>AAA	p.K1351K	ZFHX4_uc003yau.1_Silent_p.K1396K|ZFHX4_uc003yaw.1_Silent_p.K1351K	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1351						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATGTCTACAAGTATCGCTGTA	0.428			NA								HNSCC(33;0.089)			10	44					0	0	0.006214	0	0
ZFHX4	79776	broad.mit.edu	37	8	77776174	77776174	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr8:77776174C>A	uc003yav.2	+	11	10476	c.10089C>A	c.(10087-10089)TGC>TGA	p.C3363*		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3359	C2H2-type 19; degenerate.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCAGAAAGTGCCAGATGATGT	0.413			NA								HNSCC(33;0.089)			4	10					0.00909568	0.00954547	0.009096	1	0
FER1L6	654463	broad.mit.edu	37	8	125047562	125047562	+	Silent	SNP	C	C	A			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr8:125047562C>A	uc003yqw.2	+	19	2537	c.2331C>A	c.(2329-2331)GTC>GTA	p.V777V	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	777	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AAGCAAAAGTCGACGTGTACC	0.498			NA											17	69					3.32936e-07	4.07633e-07	0.006122	1	0
PARP10	84875	broad.mit.edu	37	8	145058247	145058247	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr8:145058247A>G	uc003zal.3	-	7	1814	c.1706T>C	c.(1705-1707)GTG>GCG	p.V569A	PARP10_uc003zak.3_Missense_Mutation_p.V275A|PARP10_uc011lku.1_Missense_Mutation_p.V581A|PARP10_uc011lkv.1_RNA|PARP10_uc003zam.2_Missense_Mutation_p.V569A	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	569						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCCAGGGAGCACTGGGAGGGC	0.652			NA											11	38					0	0	0.010729	0	0
TAF1L	138474	broad.mit.edu	37	9	32633525	32633525	+	Missense_Mutation	SNP	G	G	A	rs147409173		TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr9:32633525G>A	uc003zrg.1	-	1	2143	c.2053C>T	c.(2053-2055)CGC>TGC	p.R685C	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	685					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TGAGGTGTGCGCATAAAAAAC	0.448			NA											4	159					0	0	0.009096	0	0
MXRA5	25878	broad.mit.edu	37	X	3240769	3240769	+	Nonsense_Mutation	SNP	G	G	C			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chrX:3240769G>C	uc004crg.3	-	5	3114	c.2957C>G	c.(2956-2958)TCA>TGA	p.S986*		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	986						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				ATCTGGTTGTGACTTAGTCTC	0.478			NA											4	61					0	0	0.009096	0	0
PRKX	5613	broad.mit.edu	37	X	3573373	3573373	+	Missense_Mutation	SNP	C	C	A	rs145956134		TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chrX:3573373C>A	uc010nde.2	-	3	783	c.416G>T	c.(415-417)CGC>CTC	p.R139L		NM_005044	NP_005035	P51817	PRKX_HUMAN	protein kinase, X-linked	139	Protein kinase.						ATP binding|cAMP-dependent protein kinase activity			skin(2)|lung(1)	3		all_lung(23;0.000396)|Lung NSC(23;0.00123)				CCCCCGGTTGCGCAGGTAGCT	0.602			NA											25	17					2.61193e-14	3.6954e-14	0.009535	1	0
FAM47C	442444	broad.mit.edu	37	X	37028496	37028496	+	Silent	SNP	C	C	T			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chrX:37028496C>T	uc004ddl.1	+	1	2027	c.2013C>T	c.(2011-2013)CCC>CCT	p.P671P		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	671										ovary(3)	3						CGGAGCCCCCCGAGACTGGAG	0.647			NA											7	20					0	0	0.010729	0	0
SEC16B	89866	broad.mit.edu	37	1	177901694	177901694	+	Frame_Shift_Del	DEL	T	T	-			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr1:177901694delT	uc001gli.1	-	24	3033	c.2943delA	c.(2941-2943)GAAfs	p.E981fs	SEC16B_uc001glk.1_Frame_Shift_Del_p.E658fs|SEC16B_uc009wwy.1_Frame_Shift_Del_p.K500fs|SEC16B_uc001glh.1_Frame_Shift_Del_p.E641fs|SEC16B_uc009wwz.1_Frame_Shift_Del_p.E640fs|SEC16B_uc001glj.1_Frame_Shift_Del_p.E982fs	NM_033127	NP_149118	Q96JE7	SC16B_HUMAN	leucine zipper transcription regulator 2	981					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				ovary(3)|central_nervous_system(1)	4						ATCCTCGGCCTTCACCCCCAC	0.662			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
DOT1L	84444	broad.mit.edu	37	19	2213544	2213544	+	Frame_Shift_Del	DEL	A	A	-			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr19:2213544delA	uc002lvb.3	+	17	1600	c.1564delA	c.(1564-1566)AACfs	p.N522fs	DOT1L_uc002lvc.1_5'UTR|uc002lvd.1_RNA|DOT1L_uc002lve.1_5'Flank	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	522						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACAGGAGAAGAACGCCCAGCT	0.607			NA											22	54	---	---	---	---	NA	NA	NA	NA	NA
TTC7A	57217	broad.mit.edu	37	2	47233194	47233195	+	Frame_Shift_Del	DEL	CG	CG	-	rs142616749		TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr2:47233194_47233195delCG	uc002rvo.2	+	9	1567_1568	c.1199_1200delCG	c.(1198-1200)TCGfs	p.S400fs	TTC7A_uc002rvm.2_Frame_Shift_Del_p.S366fs|TTC7A_uc002rvn.1_Frame_Shift_Del_p.S281fs|TTC7A_uc010fbb.2_Frame_Shift_Del_p.S400fs|TTC7A_uc010fbc.2_Frame_Shift_Del_p.S46fs|TTC7A_uc002rvp.2_Frame_Shift_Del_p.S281fs|TTC7A_uc002rvq.2_Frame_Shift_Del_p.S140fs|TTC7A_uc002rvr.2_5'UTR	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	400							binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			GTCATGCTCTCGGAGGTACGGC	0.584			NA											11	65	---	---	---	---	NA	NA	NA	NA	NA
ALMS1	7840	broad.mit.edu	37	2	73676086	73676093	+	Frame_Shift_Del	DEL	ACTCACAC	ACTCACAC	-			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	ACTCACAC	ACTCACAC	-	-	ACTCACAC	ACTCACAC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr2:73676086_73676093delACTCACAC	uc002sje.1	+	10	2546_2553	c.2435_2442delACTCACAC	c.(2434-2442)TACTCACACfs	p.Y812fs	ALMS1_uc002sjf.1_Frame_Shift_Del_p.Y768fs|ALMS1_uc002sjg.2_Frame_Shift_Del_p.Y198fs|ALMS1_uc002sjh.1_Frame_Shift_Del_p.Y198fs	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	810_812	6.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TCTAGTGCATACTCACACAGAGAGAAGC	0.505			NA											32	122	---	---	---	---	NA	NA	NA	NA	NA
LAMC3	10319	broad.mit.edu	37	9	133946977	133946977	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4384-01A-01D-1753-08	TCGA-05-4384-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c71b66b-813f-472b-b866-b34b5b9199e7	2011ef98-2f99-44e0-a561-e14eb6f2d1f8	g.chr9:133946977delG	uc004caa.1	+	18	3274	c.3176delG	c.(3175-3177)AGGfs	p.R1059fs		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	1059	Cell attachment site (Potential).|Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		GAGGCCCCAAGGGGGGACGTC	0.657			NA											16	65	---	---	---	---	NA	NA	NA	NA	NA
