Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TAS1R3	83756	broad.mit.edu	37	1	1268139	1268139	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:1268139T>A	uc010nyk.1	+	3	1228	c.1228T>A	c.(1228-1230)TGC>AGC	p.C410S		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	410	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	CACTCTTCAGTGCAACGCCTC	0.642			NA											3	30					0	0	0.009096	0	0
ATAD3C	219293	broad.mit.edu	37	1	1387814	1387814	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:1387814G>T	uc001aft.2	+	3	1217	c.222G>T	c.(220-222)ACG>ACT	p.T74T		NM_001039211	NP_001034300	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	74							ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TGACAGCCACGGTAAACATAC	0.602			NA											21	63					3.62473e-10	5.25126e-10	0.001882	1	0
ATAD3B	83858	broad.mit.edu	37	1	1420477	1420477	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:1420477C>T	uc001afv.2	+	8	933	c.832C>T	c.(832-834)CGG>TGG	p.R278W	ATAD3B_uc001afx.2_Missense_Mutation_p.R232W	NM_031921	NP_114127	Q5T9A4	ATD3B_HUMAN	AAA-ATPase  TOB3	278							ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CATCGAGGCTCGGCTGGGGAA	0.682			NA											4	13					0	0	0.009096	0	0
ACTRT2	140625	broad.mit.edu	37	1	2938660	2938660	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:2938660A>G	uc001ajz.2	+	1	615	c.410A>G	c.(409-411)TAC>TGC	p.Y137C		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	137						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		CCCGCTTTCTACCTGTCGGAC	0.627			NA											10	43					0	0	0.006214	0	0
AJAP1	55966	broad.mit.edu	37	1	4772109	4772109	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:4772109C>T	uc001alm.1	+	2	560	c.179C>T	c.(178-180)CCG>CTG	p.P60L	AJAP1_uc001aln.2_Missense_Mutation_p.P60L	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	60	Extracellular (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		ccgccccggccgccccggcTG	0.592			NA											5	88					0	0	0.001168	0	0
TAS1R1	80835	broad.mit.edu	37	1	6639186	6639186	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:6639186C>A	uc001ant.2	+	6	2068	c.2068C>A	c.(2068-2070)CAG>AAG	p.Q690K	TAS1R1_uc001anu.2_Missense_Mutation_p.Q436K|TAS1R1_uc001anv.2_Intron|TAS1R1_uc001anw.2_3'UTR|ZBTB48_uc009vmc.1_5'Flank|ZBTB48_uc001anx.2_5'Flank|ZBTB48_uc009vmd.1_5'Flank	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	690	Helical; Name=4; (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		CTCAGCGGCCCAGCTGCTTAT	0.537			NA											16	91					1.15088e-07	1.5071e-07	0.004007	1	0
NMNAT1	64802	broad.mit.edu	37	1	10035810	10035810	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:10035810G>T	uc001aqp.2	+	3	420	c.276G>T	c.(274-276)TGG>TGT	p.W92C		NM_022787	NP_073624	Q9HAN9	NMNA1_HUMAN	nicotinamide mononucleotide adenylyltransferase	92					water-soluble vitamin metabolic process	nucleoplasm	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity|protein binding				0		all_lung(284;0.000407)|Renal(390;0.000469)|Lung NSC(185;0.000577)|Colorectal(325;0.0062)|Breast(348;0.00686)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.31e-08)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(185;0.00028)|BRCA - Breast invasive adenocarcinoma(304;0.00032)|KIRC - Kidney renal clear cell carcinoma(229;0.00101)|STAD - Stomach adenocarcinoma(132;0.00908)|READ - Rectum adenocarcinoma(331;0.0419)		AGAAGGAGTGGAAAGAGACTC	0.388			NA											18	89					5.26018e-13	8.14138e-13	0.001882	1	0
KIF1B	23095	broad.mit.edu	37	1	10394657	10394657	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:10394657G>A	uc001aqx.3	+	28	3206	c.3004G>A	c.(3004-3006)GTG>ATG	p.V1002M	KIF1B_uc001aqw.3_Missense_Mutation_p.V956M|KIF1B_uc001aqy.2_Missense_Mutation_p.V976M|KIF1B_uc001aqz.2_Missense_Mutation_p.V1002M|KIF1B_uc001ara.2_Missense_Mutation_p.V962M|KIF1B_uc001arb.2_Missense_Mutation_p.V988M	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	1002					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		GAAAGGTGAAGTGCGGGGATT	0.522			NA											34	92					0	0	0.002445	0	0
VPS13D	55187	broad.mit.edu	37	1	12414217	12414217	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:12414217G>T	uc001atv.2	+	47	9759	c.9618G>T	c.(9616-9618)ACG>ACT	p.T3206T	VPS13D_uc001atw.2_Silent_p.T3181T|VPS13D_uc001atx.2_Silent_p.T2393T	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3205					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTAATGGGACGCTGAAACCTG	0.433			NA											19	67					2.37509e-13	3.70207e-13	0.010504	1	0
PADI2	11240	broad.mit.edu	37	1	17396687	17396687	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:17396687T>A	uc001baf.2	-	15	1742	c.1660A>T	c.(1660-1662)ATC>TTC	p.I554F	PADI2_uc010ocm.1_Missense_Mutation_p.I438F	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	554					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	TTCTTGAGGATGTCACGGTTC	0.587			NA											32	113					0	0	0.00874	0	0
PADI4	23569	broad.mit.edu	37	1	17674519	17674519	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:17674519G>A	uc001baj.2	+	10	1159	c.1131G>A	c.(1129-1131)AAG>AAA	p.K377K	PADI4_uc009vpc.2_Silent_p.K377K	NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	377					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	GAGGCCTGAAGGAGTTTCCCA	0.567			NA											5	30					0	0	0.001168	0	0
UBR4	23352	broad.mit.edu	37	1	19478261	19478261	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:19478261C>A	uc001bbi.2	-	48	7093	c.7089G>T	c.(7087-7089)CGG>CGT	p.R2363R	UBR4_uc001bbk.1_Silent_p.R17R|UBR4_uc001bbl.1_Silent_p.R300R|UBR4_uc001bbm.1_Silent_p.R1575R	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2363					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		ATGACGGGGCCCGTTCTATTG	0.522			NA											22	76					4.26978e-12	6.47191e-12	0.00333	1	0
PLA2G2A	5320	broad.mit.edu	37	1	20304510	20304510	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:20304510C>A	uc001bcu.2	-	4	508	c.290G>T	c.(289-291)TGT>TTT	p.C97F	PLA2G2A_uc001bcv.2_Missense_Mutation_p.C97F|PLA2G2A_uc010oda.1_Missense_Mutation_p.C97F|PLA2G2A_uc010odb.1_Missense_Mutation_p.C97F	NM_001161729	NP_001155201	P14555	PA2GA_HUMAN	phospholipase A2, group IIA precursor	97					defense response to Gram-positive bacterium|lipid catabolic process|low-density lipoprotein particle remodeling|phosphatidic acid metabolic process|positive regulation of inflammatory response|positive regulation of macrophage derived foam cell differentiation	endoplasmic reticulum|extracellular space|membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|phospholipid binding				0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000138)|Kidney(64;0.000171)|GBM - Glioblastoma multiforme(114;0.00032)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		ACTCTTACCACAGGTGATTCT	0.393			NA											16	78					0.000422831	0.000478794	0.004007	1	0
HSPG2	3339	broad.mit.edu	37	1	22176624	22176624	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:22176624C>G	uc001bfj.2	-	57	7396	c.7356G>C	c.(7354-7356)CAG>CAC	p.Q2452H	HSPG2_uc009vqd.2_Missense_Mutation_p.Q2453H	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2452	Ig-like C2-type 10.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGTCCAGGGTCTGCCCCTCGG	0.672			NA											12	117					0	0	0.000978	0	0
HSPG2	3339	broad.mit.edu	37	1	22222419	22222419	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:22222419C>T	uc001bfj.2	-	3	280	c.240G>A	c.(238-240)CAG>CAA	p.Q80Q	HSPG2_uc009vqd.2_Silent_p.Q80Q|HSPG2_uc009vqe.1_Silent_p.Q35Q	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	80	SEA.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	ACTTACCCATCTGGAAGTCCC	0.522			NA											6	39					0	0	0.00308	0	0
TMEM57	55219	broad.mit.edu	37	1	25824928	25824928	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:25824928G>C	uc001bkk.2	+	11	2168	c.1966G>C	c.(1966-1968)GCC>CCC	p.A656P	TMEM57_uc009vru.2_Missense_Mutation_p.A429P|TMEM57_uc009vrv.2_Missense_Mutation_p.A298P	NM_018202	NP_060672	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	656						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part					0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		TGACCCCAATGCCTCTGTTTA	0.542			NA											28	80					0	0	0.008361	0	0
SPOCD1	90853	broad.mit.edu	37	1	32259395	32259395	+	Silent	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:32259395T>C	uc001bts.1	-	12	2545	c.2487A>G	c.(2485-2487)CCA>CCG	p.P829P	SPOCD1_uc001btr.1_5'Flank|SPOCD1_uc001btt.2_Silent_p.P134P|SPOCD1_uc001btu.2_Silent_p.P829P|SPOCD1_uc001btv.2_Silent_p.P322P	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	829					transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		TGGGCATCTCTGGAGCAGGCA	0.597			NA											13	177					0	0	0.00245	0	0
BSDC1	55108	broad.mit.edu	37	1	32842006	32842006	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:32842006G>A	uc001bvh.3	-	9	1060	c.1013C>T	c.(1012-1014)ACG>ATG	p.T338M	BSDC1_uc010ohg.1_Missense_Mutation_p.T355M|BSDC1_uc010ohh.1_Missense_Mutation_p.T282M|BSDC1_uc010ohi.1_Missense_Mutation_p.T243M|BSDC1_uc001bvg.3_RNA|BSDC1_uc001bvj.2_Missense_Mutation_p.T234M|BSDC1_uc001bvi.2_Missense_Mutation_p.T355M	NM_018045	NP_060515	Q9NW68	BSDC1_HUMAN	BSD domain containing 1 isoform b	338							protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GCCAGCAGGCGTTAGGGGCTT	0.622			NA											12	141					0	0	0.001855	0	0
CSMD2	114784	broad.mit.edu	37	1	34204909	34204909	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:34204909G>C	uc001bxn.1	-	15	2109	c.2080C>G	c.(2080-2082)CCT>GCT	p.P694A	CSMD2_uc001bxm.1_Missense_Mutation_p.P734A	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	694	Sushi 4.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGAACGCCAGGATCCGGGCAC	0.522			NA											33	110					0	0	0.002445	0	0
DLGAP3	58512	broad.mit.edu	37	1	35365744	35365744	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:35365744G>T	uc001byc.2	-	2	1238	c.1238C>A	c.(1237-1239)CCC>CAC	p.P413H		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	413					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				AGATGTCTTGGGGCTGCCGTC	0.652			NA											13	81					0.00185496	0.00205513	0.001855	1	0
MACF1	23499	broad.mit.edu	37	1	39826501	39826501	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:39826501G>T	uc010oiu.1	+	12	7732	c.7601G>T	c.(7600-7602)AGC>ATC	p.S2534I	MACF1_uc010ois.1_Missense_Mutation_p.S2032I|MACF1_uc001cda.1_Missense_Mutation_p.S1940I|MACF1_uc001cdc.1_Missense_Mutation_p.S1119I|MACF1_uc001cdb.1_Missense_Mutation_p.S1119I	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4099	Spectrin 2.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTCTCCTATAGCCTGGCTGAG	0.443			NA											8	42					5.18039e-06	6.37205e-06	0.00308	1	0
NT5C1A	84618	broad.mit.edu	37	1	40128985	40128985	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:40128985C>A	uc001cdq.1	-	4	555	c.555G>T	c.(553-555)GAG>GAT	p.E185D		NM_032526	NP_115915	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	185					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TAGACTTACCCTCATCAATGG	0.552			NA											20	90					5.35356e-11	7.91977e-11	0.00278	1	0
COL9A2	1298	broad.mit.edu	37	1	40776820	40776820	+	Splice_Site	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:40776820T>A	uc001cfh.1	-	12	647	c.577_splice	c.e12-1	p.G193_splice	COL9A2_uc001cfi.1_Splice_Site_p.G12_splice	NM_001852	NP_001843	Q14055	CO9A2_HUMAN	alpha 2 type IX collagen precursor						axon guidance|skeletal system development	collagen type IX				ovary(2)	2	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			CGCATGCCCCTGAAGGGAAGG	0.622			NA											14	39					0	0	0.004007	0	0
ZNF643	65243	broad.mit.edu	37	1	40929215	40929215	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:40929215G>T	uc001cfn.1	+	5	1856	c.1559G>T	c.(1558-1560)AGA>ATA	p.R520I	ZNF643_uc001cfl.1_Missense_Mutation_p.R418I|ZNF643_uc001cfm.1_Missense_Mutation_p.R386I	NM_023070	NP_075558	Q9UJL9	ZN643_HUMAN	zinc finger protein 643	520	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.25e-18)			TCCCTTATTAGACACTGCAAA	0.348			NA											6	54					2.7689e-08	3.74372e-08	0.001984	1	0
RAD54L	8438	broad.mit.edu	37	1	46725742	46725742	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:46725742G>T	uc009vye.2	+	6	492	c.378G>T	c.(376-378)CTG>CTT	p.L126L	RAD54L_uc001cpl.2_Silent_p.L126L|RAD54L_uc001cpm.1_5'UTR	NM_001142548	NP_001136020	Q92698	RAD54_HUMAN	RAD54-like protein	126					meiosis	nucleus	ATP binding|DNA binding|helicase activity			ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		CTCCCCCGCTGAGCGCTCATG	0.557			NA						Direct_reversal_of_damage|Homologous_recombination					25	144					1.66031e-10	2.42587e-10	0.003954	1	0
CYP4B1	1580	broad.mit.edu	37	1	47279690	47279690	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:47279690G>T	uc001cqm.3	+	6	811	c.727G>T	c.(727-729)GGC>TGC	p.G243C	CYP4B1_uc009vyl.1_Missense_Mutation_p.G80C|CYP4B1_uc001cqn.3_Missense_Mutation_p.G244C|CYP4B1_uc009vym.2_Missense_Mutation_p.G229C|CYP4B1_uc010omk.1_Missense_Mutation_p.G80C|CYP4B1_uc010oml.1_Missense_Mutation_p.G81C	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	243					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					CACCCCACATGGCCGCCGCTT	0.592			NA											31	106					9.04072e-19	1.54354e-18	0.003271	1	0
CYP4A11	1579	broad.mit.edu	37	1	47400232	47400232	+	Splice_Site	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:47400232C>G	uc001cqp.3	-	7	842	c.791_splice	c.e7-1	p.D264_splice	CYP4A11_uc001cqq.2_Splice_Site_p.D264_splice|CYP4A11_uc010omm.1_Splice_Site	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,						long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	ATCACTTGGTCTGTACCAGAA	0.542			NA											3	59					0	0	0.009096	0	0
PODN	127435	broad.mit.edu	37	1	53541610	53541610	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:53541610A>G	uc001cuv.2	+	5	699	c.692A>G	c.(691-693)TAT>TGT	p.Y231C	PODN_uc001cuw.2_Missense_Mutation_p.Y212C|PODN_uc010onr.1_Missense_Mutation_p.Y212C|PODN_uc010ons.1_Intron	NM_153703	NP_714914	Q7Z5L7	PODN_HUMAN	podocan	183	LRR 4.				negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			ovary(1)|pancreas(1)	2						ACCAAGATCTATGGGCTCACC	0.617			NA											5	15					0	0	0.001984	0	0
C1orf83	127428	broad.mit.edu	37	1	54520164	54520165	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:54520164_54520165GG>TT	uc001cwt.1	+	2	269_270	c.69_70GG>TT	c.(67-72)AAGGTT>AATTTT	p.23_24KV>NF	C1orf83_uc001cwu.1_RNA|TMEM59_uc001cwp.2_5'Flank|TMEM59_uc001cwq.2_5'Flank|TMEM59_uc001cwr.2_5'Flank|TMEM59_uc001cws.1_5'Flank	NM_153035	NP_694580	Q96MN5	TEAN2_HUMAN	hypothetical protein LOC127428	23_24					transcription, DNA-dependent	nucleus	DNA binding				0						CTGGAGGAAAGGTTTACAAGCA	0.48			NA											8	43					0	0	0.004672	0	0
C1orf175	374977	broad.mit.edu	37	1	55145645	55145645	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:55145645G>T	uc010ooe.1	+	13	2632	c.2308G>T	c.(2308-2310)GTC>TTC	p.V770F	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Missense_Mutation_p.V338F|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Missense_Mutation_p.V288F|C1orf175_uc010oof.1_Intron|C1orf175_uc001cxr.1_Intron|C1orf175_uc010oog.1_Missense_Mutation_p.V770F|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA|C1orf175_uc009vzr.1_5'Flank	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	770	Helical; (Potential).					integral to membrane	binding				0						CCTGCTGCCCGTCTCCCTCCT	0.637			NA											38	168					3.38236e-24	6.03572e-24	0.006999	1	0
C8B	732	broad.mit.edu	37	1	57415296	57415296	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:57415296G>A	uc001cyp.2	-	6	863	c.796C>T	c.(796-798)CTT>TTT	p.L266F	C8B_uc010oon.1_Missense_Mutation_p.L204F|C8B_uc010ooo.1_Missense_Mutation_p.L214F	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	266	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						CTGATGCCAAGTTCAAATATT	0.353			NA											4	62					0	0	0.009096	0	0
HOOK1	51361	broad.mit.edu	37	1	60287598	60287598	+	Silent	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:60287598A>T	uc009wad.2	+	3	234	c.132A>T	c.(130-132)GCA>GCT	p.A44A	HOOK1_uc001czo.2_Silent_p.A44A|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Silent_p.A2A	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	44	Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)					TTGCCATGGCACAAGTTCTTC	0.403			NA											11	45					0	0	0.001855	0	0
L1TD1	54596	broad.mit.edu	37	1	62675725	62675725	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:62675725G>T	uc001dae.3	+	4	1581	c.1279G>T	c.(1279-1281)GAT>TAT	p.D427Y		NM_019079	NP_061952	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	427	Glu-rich.									ovary(1)|skin(1)	2						gttggaggaggatgaggcctc	0.219			NA											11	34					3.86212e-05	4.5402e-05	0.008291	1	0
KANK4	163782	broad.mit.edu	37	1	62740301	62740301	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:62740301G>C	uc001dah.3	-	3	852	c.475C>G	c.(475-477)CTC>GTC	p.L159V	KANK4_uc001dai.3_Intron|KANK4_uc001dag.3_5'Flank	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	159										ovary(3)|skin(2)|lung(1)	6						GCTCTCAAGAGCTGGGGCCGT	0.652			NA											5	31					0	0	0.001168	0	0
WDR78	79819	broad.mit.edu	37	1	67292659	67292659	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:67292659C>A	uc001dcx.2	-	15	2239	c.2183G>T	c.(2182-2184)GGT>GTT	p.G728V	WDR78_uc009waw.2_Missense_Mutation_p.G441V|WDR78_uc009wax.2_RNA	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	728	WD 4.									ovary(2)	2						TATAATAACACCCCAATCTGC	0.358			NA											21	146					1.55469e-16	2.58277e-16	0.00333	1	0
C1orf173	127254	broad.mit.edu	37	1	75037751	75037751	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:75037751C>A	uc001dgg.2	-	14	3862	c.3643G>T	c.(3643-3645)GCC>TCC	p.A1215S		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1215	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GCTGCTAAGGCCCCCTCTCCA	0.597			NA											28	96					4.87955e-14	7.71511e-14	0.005443	1	0
C1orf173	127254	broad.mit.edu	37	1	75038549	75038549	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:75038549C>A	uc001dgg.2	-	14	3064	c.2845G>T	c.(2845-2847)GCA>TCA	p.A949S		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	949	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TCTATGGATGCTTCCTCTTCA	0.552			NA											21	142					1.55795e-14	2.50181e-14	0.001882	1	0
PTGFR	5737	broad.mit.edu	37	1	78958528	78958528	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:78958528G>C	uc001din.2	+	2	366	c.100G>C	c.(100-102)GTA>CTA	p.V34L	PTGFR_uc001dim.2_Missense_Mutation_p.V34L	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	34	Helical; Name=1; (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	ATTTTTTTCAGTAATCTTCAT	0.443			NA											18	90					0	0	0.007413	0	0
LPHN2	23266	broad.mit.edu	37	1	82433803	82433803	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:82433803G>T	uc001dit.3	+	13	2573	c.2392G>T	c.(2392-2394)GAC>TAC	p.D798Y	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.D798Y|LPHN2_uc001div.2_Missense_Mutation_p.D798Y|LPHN2_uc009wcd.2_Missense_Mutation_p.D798Y|LPHN2_uc001diw.2_Missense_Mutation_p.D382Y|LPHN2_uc009wce.1_5'Flank	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	811	Extracellular (Potential).|GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CAAGCTGGTTGACACTAATAA	0.438			NA											17	73					4.14922e-12	6.29536e-12	0.004007	1	0
WDR63	126820	broad.mit.edu	37	1	85592309	85592309	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:85592309G>A	uc001dkt.2	+	20	2419	c.2228G>A	c.(2227-2229)TGG>TAG	p.W743*	WDR63_uc009wcl.2_Nonsense_Mutation_p.W704*	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	743	WD 4.									upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		ATTGATATCTGGGACCTTCTG	0.463			NA											6	53					0	0	0.001168	0	0
BARHL2	343472	broad.mit.edu	37	1	91178042	91178042	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:91178042C>A	uc001dns.2	-	3	1033	c.991G>T	c.(991-993)GCG>TCG	p.A331S		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	331						nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		GCAGCCGCCGCCGCCGTAGTG	0.652	GBM(199;3561 4100 22440)		NA											6	20					3.59834e-05	4.24306e-05	0.001168	1	0
HFM1	164045	broad.mit.edu	37	1	91790257	91790257	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:91790257C>T	uc001doa.3	-	21	2502	c.2402G>A	c.(2401-2403)AGT>AAT	p.S801N	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.S480N|HFM1_uc001dob.3_Missense_Mutation_p.S33N|HFM1_uc010osv.1_Missense_Mutation_p.S485N	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	801	SEC63.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TTCTTTTCCACTGATTGTATA	0.289			NA											5	48					0	0	0.001168	0	0
DNTTIP2	30836	broad.mit.edu	37	1	94342676	94342676	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:94342676C>A	uc001dqf.2	-	2	853	c.815G>T	c.(814-816)AGA>ATA	p.R272I	DNTTIP2_uc010otm.1_RNA|DNTTIP2_uc009wdo.1_Missense_Mutation_p.R67I	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,	272					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		TTCTGAACTTCTGTGGGAGAA	0.338			NA											14	81					1.49906e-05	1.79654e-05	0.00245	1	0
HIAT1	64645	broad.mit.edu	37	1	100515506	100515506	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:100515506C>A	uc001dst.2	+	2	126	c.126C>A	c.(124-126)ATC>ATA	p.I42I		NM_033055	NP_149044	Q96MC6	HIAT1_HUMAN	hippocampus abundant transcript 1	42	Helical; Name=1; (Potential).				transmembrane transport	integral to membrane|plasma membrane	transporter activity				0		all_epithelial(167;2.96e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0832)|all cancers(265;0.136)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		ATGCAGTTATCGTCATCTTTT	0.318			NA											12	68					2.61681e-11	3.89738e-11	0.00245	1	0
RTCD1	8634	broad.mit.edu	37	1	100752704	100752704	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:100752704G>T	uc001dtc.2	+	10	1162	c.944G>T	c.(943-945)GGA>GTA	p.G315V	RTCD1_uc001dtd.2_Missense_Mutation_p.G328V	NM_003729	NP_003720	O00442	RTC1_HUMAN	RNA terminal phosphate cyclase domain 1 isoform	315					RNA processing	mitochondrion|nucleoplasm	ATP binding|protein binding|RNA binding|RNA-3'-phosphate cyclase activity				0		all_epithelial(167;0.000686)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0513)|all cancers(265;0.0902)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)		ATAAAAACAGGACCAGTTACA	0.323			NA											15	67					2.39187e-15	3.902e-15	0.008871	1	0
CDC14A	8556	broad.mit.edu	37	1	100889851	100889851	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:100889851C>T	uc001dtg.3	+	5	871	c.383C>T	c.(382-384)CCA>CTA	p.P128L	CDC14A_uc009web.2_RNA|CDC14A_uc010oui.1_Missense_Mutation_p.P70L|CDC14A_uc001dte.3_Missense_Mutation_p.P128L|CDC14A_uc001dtf.2_Missense_Mutation_p.P128L|CDC14A_uc009wed.1_5'UTR|CDC14A_uc009wee.2_Missense_Mutation_p.P128L	NM_003672	NP_003663	Q9UNH5	CC14A_HUMAN	CDC14 homolog A isoform 1	128	A.				cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(1)	1		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)		CCCTATCTTCCATTCAGGTAT	0.388			NA											15	64					0	0	0.004007	0	0
CDC14A	8556	broad.mit.edu	37	1	100960421	100960422	+	Nonsense_Mutation	DNP	GG	GG	CT			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:100960421_100960422GG>CT	uc001dtg.3	+	12	1673_1674	c.1185_1186GG>CT	c.(1183-1188)CAGGGA>CACTGA	p.395_396QG>H*	CDC14A_uc009web.2_RNA|CDC14A_uc010oui.1_Nonsense_Mutation_p.337_338QG>H*|CDC14A_uc001dtf.2_Nonsense_Mutation_p.395_396QG>H*|CDC14A_uc009wed.1_Nonsense_Mutation_p.102_103QG>H*|CDC14A_uc009wee.2_Nonsense_Mutation_p.395_396QG>H*	NM_003672	NP_003663	Q9UNH5	CC14A_HUMAN	CDC14 homolog A isoform 1	395_396					cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(1)	1		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)		GTATAACCCAGGGAGACAAACT	0.371			NA											4	46					0	0	0.004672	0	0
COL11A1	1301	broad.mit.edu	37	1	103428282	103428282	+	Missense_Mutation	SNP	C	C	A	rs147271219		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:103428282C>A	uc001dul.2	-	39	3269	c.2951G>T	c.(2950-2952)CGT>CTT	p.R984L	COL11A1_uc001duk.2_Missense_Mutation_p.R180L|COL11A1_uc001dum.2_Missense_Mutation_p.R996L|COL11A1_uc001dun.2_Missense_Mutation_p.R945L|COL11A1_uc009weh.2_Missense_Mutation_p.R868L	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	984	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AGGATGCCCACGTTCCCCTAT	0.453			NA											11	83					1.58986e-06	2.00195e-06	0.008291	1	0
COL11A1	1301	broad.mit.edu	37	1	103444661	103444661	+	Splice_Site	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:103444661C>G	uc001dul.2	-	33	2929	c.2611_splice	c.e33-1	p.G871_splice	COL11A1_uc001duk.2_Splice_Site_p.G67_splice|COL11A1_uc001dum.2_Splice_Site_p.G883_splice|COL11A1_uc001dun.2_Splice_Site_p.G832_splice|COL11A1_uc009weh.2_Splice_Site_p.G755_splice	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A						collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CAGCTACTCCCTAGCAAAGAC	0.388			NA											4	31					0	0	0.009096	0	0
AMY1A	276	broad.mit.edu	37	1	104234119	104234119	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:104234119C>T	uc001dux.1	-	7	1206	c.992G>A	c.(991-993)TGG>TAG	p.W331*	AMY1A_uc001duw.1_Nonsense_Mutation_p.W331*	NM_001008221	NP_001008222	P04745	AMY1_HUMAN	salivary amylase alpha 1A precursor	331					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding|protein binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)		CCTAGCATCCCAGAAGGTAAG	0.383	Pancreas(131;743 2392 43382 44986)		NA											50	201					0	0	0.00361	0	0
NTNG1	22854	broad.mit.edu	37	1	107979327	107979327	+	Nonsense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:107979327T>A	uc001dvh.3	+	7	2014	c.1296T>A	c.(1294-1296)TGT>TGA	p.C432*	NTNG1_uc001dvf.3_Intron|NTNG1_uc010out.1_Nonsense_Mutation_p.C398*|NTNG1_uc001dvc.3_Intron|NTNG1_uc001dvi.2_5'UTR|NTNG1_uc001dve.2_RNA|NTNG1_uc009wek.2_RNA|NTNG1_uc001dvg.2_Intron|NTNG1_uc009wem.2_Intron	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	432	Laminin EGF-like 3.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		ATGATCGTTGTAATGGCTCAG	0.463			NA											8	50					0	0	0.00308	0	0
VAV3	10451	broad.mit.edu	37	1	108315437	108315437	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:108315437G>C	uc001dvk.1	-	5	529	c.475C>G	c.(475-477)CTC>GTC	p.L159V	VAV3_uc010ouw.1_Missense_Mutation_p.L159V|VAV3_uc001dvl.1_Translation_Start_Site|VAV3_uc010oux.1_Missense_Mutation_p.L159V	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	159					angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		CAGTCATAGAGATCTTCTTCA	0.388			NA											17	74					0	0	0.004007	0	0
KCNC4	3749	broad.mit.edu	37	1	110768730	110768730	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:110768730C>T	uc001dzh.2	+	3	1806	c.1749C>T	c.(1747-1749)AAC>AAT	p.N583N	KCNC4_uc009wfr.2_Silent_p.N583N|KCNC4_uc001dzg.2_Silent_p.N583N|KCNC4_uc001dzi.2_RNA	NM_004978	NP_004969	Q03721	KCNC4_HUMAN	Shaw-related voltage-gated potassium channel	583	Cytoplasmic (Potential).				synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		GAGACAGAAACAAGAAGGCAG	0.647			NA											12	39					0	0	0.001368	0	0
MAN1A2	10905	broad.mit.edu	37	1	118045579	118045579	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:118045579G>T	uc001ehd.1	+	12	2501	c.1780G>T	c.(1780-1782)GCT>TCT	p.A594S		NM_006699	NP_006690	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	594	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity				0	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		CTTTTTTCTTGCTGAAACATT	0.338	Ovarian(33;199 881 8228 13687 31538)		NA											5	32					0.000602214	0.000674971	0.000602	1	0
NOTCH2	4853	broad.mit.edu	37	1	120461117	120461117	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:120461117G>A	uc001eik.2	-	32	6097	c.5841C>T	c.(5839-5841)CCC>CCT	p.P1947P		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	1947	Cytoplasmic (Potential).|ANK 4.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCAGGATCAGGGGTGTAGTAC	0.502			NA	N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				14	62					0	0	0.001855	0	0
NBPF9	400818	broad.mit.edu	37	1	144828733	144828733	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:144828733G>T	uc009wig.1	+	23	2854	c.2778G>T	c.(2776-2778)ACG>ACT	p.T926T	NBPF9_uc010oxn.1_Silent_p.T824T|NBPF9_uc010oxo.1_Silent_p.T851T|NBPF9_uc010oxr.1_Silent_p.T953T|NBPF9_uc010oxt.1_Silent_p.T741T|NBPF9_uc001ekg.1_Silent_p.T253T|NBPF9_uc001ekk.1_Silent_p.T497T|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Silent_p.T253T|NBPF9_uc010oye.1_Intron|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|NBPF9_uc001elp.2_Silent_p.T586T|uc001elr.3_5'Flank	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	926	NBPF 7.					cytoplasm					0						TTACTTTGACGGTGACAAGTC	0.458			NA											24	464					1.96895e-08	2.67152e-08	0.00278	1	0
ANKRD35	148741	broad.mit.edu	37	1	145558896	145558896	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:145558896T>A	uc001eob.1	+	7	623	c.515T>A	c.(514-516)CTG>CAG	p.L172Q	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Missense_Mutation_p.L15Q	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	172	ANK 4.									ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGCTCACAGCTGCTGCAGCGA	0.547	Melanoma(9;127 754 22988 51047)		NA											28	139					0	0	0.002096	0	0
GJA8	2703	broad.mit.edu	37	1	147380368	147380368	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:147380368G>T	uc001epu.1	+	2	349	c.286G>T	c.(286-288)GCG>TCG	p.A96S		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	96	Helical; (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity	p.A96V(1)		ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					CGTGGGGCACGCGGTGCACTA	0.657	Melanoma(76;1255 1795 8195 52096)		NA											38	44					3.09479e-21	5.3792e-21	0.006999	1	0
TARS2	80222	broad.mit.edu	37	1	150469316	150469316	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:150469316A>T	uc001euq.2	+	9	959	c.952A>T	c.(952-954)AGC>TGC	p.S318C	TARS2_uc010pcd.1_RNA|TARS2_uc001eur.2_Intron|TARS2_uc009wlt.2_Intron|TARS2_uc009wls.2_Intron	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	318					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	CCATGAACTGAGCCCTGGGAG	0.522			NA											9	93					0	0	0.008291	0	0
FLG	2312	broad.mit.edu	37	1	152277576	152277576	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:152277576G>A	uc001ezu.1	-	3	9822	c.9786C>T	c.(9784-9786)GCC>GCT	p.A3262A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3262	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCCGTGACCGGCTCTGTCTT	0.582			NA							Ichthyosis				23	625					0	0	0.002299	0	0
FLG2	388698	broad.mit.edu	37	1	152326249	152326249	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:152326249C>A	uc001ezw.3	-	3	4086	c.4013G>T	c.(4012-4014)AGA>ATA	p.R1338I	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1338							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCAGATGTTCTGGAACCTGT	0.488			NA											16	351					3.41278e-10	4.95352e-10	0.00499	1	0
CRNN	49860	broad.mit.edu	37	1	152382339	152382339	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:152382339C>A	uc001ezx.2	-	3	1293	c.1219G>T	c.(1219-1221)GGG>TGG	p.G407W		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	407					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGCTTGCCCCAGTCTGGGCC	0.607			NA											54	69					1.83081e-24	3.27082e-24	0.00361	1	0
LCE2D	353141	broad.mit.edu	37	1	152636662	152636662	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:152636662G>A	uc001fag.2	+	2	136	c.81G>A	c.(79-81)AAG>AAA	p.K27K		NM_178430	NP_848517	Q5TA82	LCE2D_HUMAN	late cornified envelope 2D	27	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCCACCTAAGTGTCCCCCCA	0.582			NA											60	96					0	0	0.00361	0	0
LELP1	149018	broad.mit.edu	37	1	153177398	153177398	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:153177398A>T	uc001fbl.2	+	2	325	c.215A>T	c.(214-216)CAG>CTG	p.Q72L		NM_001010857	NP_001010857	Q5T871	LELP1_HUMAN	late cornified envelope-like proline-rich 1	72	Cys/Pro-rich.									ovary(1)	1	all_lung(78;3.51e-31)|Lung NSC(65;1.34e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGCCCTCCCCAGCCCTGCACC	0.622			NA											37	36					0	0	0.003271	0	0
PGLYRP3	114771	broad.mit.edu	37	1	153274952	153274952	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:153274952G>T	uc001fbn.1	-	5	714	c.661C>A	c.(661-663)CAG>AAG	p.Q221K		NM_052891	NP_443123	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3 precursor	221					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACGACAGTCTGGCAGTCTGTG	0.478			NA											38	244					5.71845e-15	9.28947e-15	0.005524	1	0
THBS3	7059	broad.mit.edu	37	1	155165670	155165670	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:155165670C>G	uc001fix.2	-	23	2856	c.2833G>C	c.(2833-2835)GAG>CAG	p.E945Q	RAG1AP1_uc010pey.1_Intron|MUC1_uc010pfc.1_5'Flank|MUC1_uc009wph.2_5'Flank|MUC1_uc010pfd.1_5'Flank|MUC1_uc010pfe.1_5'Flank|MUC1_uc010pff.1_5'Flank|MUC1_uc009wpi.2_5'Flank|MUC1_uc010pfg.1_5'Flank|MUC1_uc010pfh.1_5'Flank|MUC1_uc010pfi.1_5'Flank|MUC1_uc010pfj.1_5'Flank|MUC1_uc010pfk.1_5'Flank|MUC1_uc010pfl.1_5'Flank|MUC1_uc001fin.2_5'Flank|MUC1_uc009wpk.2_5'Flank|MUC1_uc001fip.2_5'Flank|MUC1_uc009wqg.2_5'Flank|MUC1_uc009wpo.2_5'Flank|MUC1_uc009wps.2_5'Flank|MUC1_uc009wpt.2_5'Flank|MUC1_uc001fic.2_5'Flank|MUC1_uc009wpu.2_5'Flank|MUC1_uc009wpq.2_5'Flank|MUC1_uc009wpv.2_5'Flank|MUC1_uc001fim.2_5'Flank|MUC1_uc001fib.2_5'Flank|MUC1_uc009wpw.2_5'Flank|MUC1_uc001fie.2_5'Flank|MUC1_uc009wpr.2_5'Flank|MUC1_uc001fig.2_5'Flank|MUC1_uc001fif.2_5'Flank|MUC1_uc009wpx.2_5'Flank|MUC1_uc001fid.2_5'Flank|MUC1_uc009wpj.2_5'Flank|MUC1_uc001fij.2_5'Flank|MUC1_uc009wpy.2_5'Flank|MUC1_uc010pfm.1_5'Flank|MUC1_uc001fiq.2_5'Flank|MUC1_uc009wpz.2_5'Flank|MUC1_uc010pfn.1_5'Flank|MUC1_uc009wqa.2_5'Flank|MUC1_uc010pfo.1_5'Flank|MUC1_uc010pfp.1_5'Flank|MUC1_uc001fii.2_5'Flank|MUC1_uc001fih.2_5'Flank|MUC1_uc001fia.2_5'Flank|MUC1_uc009wqc.2_5'Flank|MUC1_uc009wqd.2_5'Flank|MUC1_uc009wqb.2_5'Flank|MUC1_uc010pfq.1_5'Flank|MUC1_uc010pfr.1_5'Flank|MUC1_uc001fit.2_5'Flank|MUC1_uc009wqe.2_5'Flank|MUC1_uc001fil.2_5'Flank|MUC1_uc009wpm.2_5'Flank|MUC1_uc009wpp.2_5'Flank|MUC1_uc010pfs.1_5'Flank|MUC1_uc001fik.2_5'Flank|MUC1_uc001fio.2_5'Flank|MUC1_uc009wqf.2_5'Flank|MUC1_uc009wpl.2_5'Flank|MUC1_uc009wpn.2_5'Flank|MUC1_uc001fis.1_5'Flank|MUC1_uc010pft.1_5'Flank|MUC1_uc001fiv.1_5'Flank|MUC1_uc001fiw.1_5'Flank|THBS3_uc009wqi.2_Missense_Mutation_p.E936Q|THBS3_uc001fiz.2_Missense_Mutation_p.E908Q|THBS3_uc001fiy.2_Missense_Mutation_p.E474Q|THBS3_uc010pfu.1_Missense_Mutation_p.E825Q	NM_007112	NP_009043	P49746	TSP3_HUMAN	thrombospondin 3 precursor	945					cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(3)|ovary(2)	5	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CGGAATGGCTCAAAGTCCTCA	0.522			NA											12	206					0	0	0.00245	0	0
CLK2	1196	broad.mit.edu	37	1	155233067	155233067	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:155233067C>A	uc001fjy.2	-	13	1732	c.1442G>T	c.(1441-1443)CGC>CTC	p.R481L	RAG1AP1_uc010pey.1_Intron|SCAMP3_uc001fjr.2_5'Flank|SCAMP3_uc001fjs.2_5'Flank|SCAMP3_uc001fju.2_5'Flank|SCAMP3_uc001fjv.2_5'Flank|SCAMP3_uc001fjt.2_5'Flank|CLK2_uc001fjw.2_Missense_Mutation_p.R480L|CLK2_uc001fjx.2_Missense_Mutation_p.R253L|CLK2_uc009wqm.2_Missense_Mutation_p.R481L	NM_003993	NP_003984	P49760	CLK2_HUMAN	CDC-like kinase 2	481						nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			AGCCCGAAGGCGGGCGAAGAA	0.567			NA						Other_conserved_DNA_damage_response_genes					23	20					6.44725e-10	9.27922e-10	0.002299	1	0
DAP3	7818	broad.mit.edu	37	1	155699058	155699058	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:155699058G>A	uc001flq.2	+	9	913	c.744G>A	c.(742-744)AAG>AAA	p.K248K	DAP3_uc001flr.2_Silent_p.K248K|DAP3_uc001fls.2_Silent_p.K248K|DAP3_uc010pgl.1_Silent_p.K207K|DAP3_uc001flt.2_Silent_p.K214K|DAP3_uc001flu.2_Silent_p.K221K|DAP3_uc010pgm.1_Silent_p.K214K	NM_033657	NP_387506	P51398	RT29_HUMAN	death-associated protein 3	248					induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			ovary(1)	1	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					AAGAGCTAAAGAGGCAAAGTT	0.488			NA											60	108					0	0	0.00361	0	0
KIAA0907	22889	broad.mit.edu	37	1	155891679	155891679	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:155891679G>C	uc001fmi.1	-	9	1009	c.985C>G	c.(985-987)CAG>GAG	p.Q329E	KIAA0907_uc001fmj.1_Missense_Mutation_p.Q329E|KIAA0907_uc009wrk.1_Missense_Mutation_p.Q186E|KIAA0907_uc009wrl.1_RNA|SNORA42_uc001fmk.1_5'Flank|KIAA0907_uc001fml.1_Missense_Mutation_p.Q329E	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	329											0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			GTATTAATCTGATTCACAAAT	0.368			NA											3	39					0	0	0.009096	0	0
NTRK1	4914	broad.mit.edu	37	1	156846197	156846197	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:156846197G>A	uc001fqh.1	+	14	1694	c.1638G>A	c.(1636-1638)CTG>CTA	p.L546L	NTRK1_uc001fqf.1_Silent_p.L510L|NTRK1_uc009wsi.1_Silent_p.L245L|NTRK1_uc001fqi.1_Silent_p.L540L|NTRK1_uc009wsk.1_Silent_p.L543L	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	546	Cytoplasmic (Potential).|Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	TCCAGGCACTGAAGGAGGCGT	0.652			NA	T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			12	30					0	0	0.000978	0	0
CD5L	922	broad.mit.edu	37	1	157805936	157805936	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:157805936G>T	uc001frk.3	-	3	208	c.65C>A	c.(64-66)TCT>TAT	p.S22Y		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	22					apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCGCACTCCAGATGGAGACGC	0.597			NA											6	59					0.00116845	0.0012964	0.001168	1	0
KIRREL	55243	broad.mit.edu	37	1	158064101	158064101	+	Splice_Site	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:158064101A>G	uc001frn.3	+	14	2124	c.1720_splice	c.e14-2	p.S574_splice	KIRREL_uc010pib.1_Splice_Site_p.S474_splice|KIRREL_uc009wsq.2_Splice_Site_p.S410_splice|KIRREL_uc001fro.3_Splice_Site_p.S388_splice|uc001frp.2_5'Flank	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor							integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					GCTGCTCCACAGTCGTTTAAG	0.617			NA											4	23					0	0	0.009096	0	0
CD1C	911	broad.mit.edu	37	1	158262102	158262102	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:158262102C>A	uc001fru.2	+	3	849	c.557C>A	c.(556-558)CCC>CAC	p.P186H	CD1C_uc001frv.2_5'UTR	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	186	Extracellular (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					AGCACTTGCCCCCGATTTCTC	0.453			NA											160	362					1.11784e-71	2.14113e-71	0.00361	1	0
OR10X1	128367	broad.mit.edu	37	1	158549326	158549326	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:158549326C>T	uc010pin.1	-	1	364	c.364G>A	c.(364-366)GGA>AGA	p.G122R		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	122	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					CCACCAAGTCCCAAGAAGAAG	0.468			NA											6	140					0	0	0.001984	0	0
SPTA1	6708	broad.mit.edu	37	1	158596725	158596725	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:158596725G>A	uc001fst.1	-	41	5936	c.5737C>T	c.(5737-5739)CTG>TTG	p.L1913L		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1913	Spectrin 18.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GCCTTAGCCAGAGAAGGGGTC	0.438			NA											22	277					0	0	0.00278	0	0
SPTA1	6708	broad.mit.edu	37	1	158647625	158647625	+	Splice_Site	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:158647625C>A	uc001fst.1	-	7	1012	c.813_splice	c.e7-1	p.R271_splice		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1						actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					AGTCACATCCCTGCAGTCATT	0.493			NA											37	81					9.14704e-12	1.37832e-11	0.00874	1	0
OR6N2	81442	broad.mit.edu	37	1	158746535	158746535	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:158746535G>A	uc010pir.1	-	1	891	c.891C>T	c.(889-891)ATC>ATT	p.I297I		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					TAGCTTTAATGATTTCCTTGT	0.408			NA											14	164					0	0	0.003163	0	0
CASQ1	844	broad.mit.edu	37	1	160165750	160165750	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:160165750C>A	uc010pja.1	+	6	972	c.715C>A	c.(715-717)CCT>ACT	p.P239T		NM_001231	NP_001222	P31415	CASQ1_HUMAN	calsequestrin 1	239						mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			central_nervous_system(1)	1	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CATGGAAGAGCCTGTGACCAT	0.567			NA											34	69					6.00712e-18	1.01771e-17	0.002445	1	0
NCSTN	23385	broad.mit.edu	37	1	160326401	160326401	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:160326401C>T	uc001fvx.2	+	15	1775	c.1651C>T	c.(1651-1653)CTT>TTT	p.L551F	NCSTN_uc001fvy.2_Missense_Mutation_p.L531F|NCSTN_uc010pjf.1_Missense_Mutation_p.L413F|NCSTN_uc001fvz.2_Missense_Mutation_p.L331F|NCSTN_uc010pjg.1_Missense_Mutation_p.L293F	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	551	Extracellular (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGACGGGCCTCTTCAACATTA	0.512			NA											88	158					0	0	0.00361	0	0
NR1I3	9970	broad.mit.edu	37	1	161205726	161205726	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:161205726G>T	uc001fzx.2	-	3	352	c.149C>A	c.(148-150)GCT>GAT	p.A50D	TOMM40L_uc009wuf.1_Intron|NR1I3_uc001fzf.2_Missense_Mutation_p.A50D|NR1I3_uc001fzg.2_Missense_Mutation_p.A21D|NR1I3_uc001fzh.2_Missense_Mutation_p.A21D|NR1I3_uc001fzi.2_Missense_Mutation_p.A21D|NR1I3_uc001fzj.2_Missense_Mutation_p.A21D|NR1I3_uc001fzk.2_Missense_Mutation_p.A21D|NR1I3_uc001fzl.2_Missense_Mutation_p.A21D|NR1I3_uc001fzm.2_Translation_Start_Site|NR1I3_uc001fzn.2_Translation_Start_Site|NR1I3_uc009wug.2_Translation_Start_Site|NR1I3_uc001fzp.2_Missense_Mutation_p.A50D|NR1I3_uc001fzo.2_Translation_Start_Site|NR1I3_uc001fzq.2_Missense_Mutation_p.A50D|NR1I3_uc001fzr.2_Missense_Mutation_p.A50D|NR1I3_uc001fzs.2_Translation_Start_Site|NR1I3_uc001fzt.2_Translation_Start_Site|NR1I3_uc001fzu.2_Missense_Mutation_p.A21D|NR1I3_uc001fzv.2_Missense_Mutation_p.A21D|NR1I3_uc001fzw.2_Missense_Mutation_p.A50D|NR1I3_uc001fzy.2_Missense_Mutation_p.A50D|NR1I3_uc001fzz.2_Missense_Mutation_p.A50D|NR1I3_uc001gaa.2_Missense_Mutation_p.A50D|NR1I3_uc001gab.2_Missense_Mutation_p.A50D|NR1I3_uc001gac.2_Missense_Mutation_p.A21D|NR1I3_uc010pkm.1_Missense_Mutation_p.A21D|NR1I3_uc010pkn.1_Missense_Mutation_p.A50D	NM_001077480	NP_001070948	Q14994	NR1I3_HUMAN	constitutive androstane receptor isoform 2	50	NR C4-type.|Nuclear receptor.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	androgen receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(1)|skin(1)	2	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			ACAGCTTCCAGCAAAGGGGCA	0.542			NA											10	70					2.80697e-09	3.93692e-09	0.000978	1	0
FCGR2A	2212	broad.mit.edu	37	1	161479793	161479793	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:161479793G>T	uc001gan.2	+	4	601	c.548G>T	c.(547-549)GGT>GTT	p.G183V	FCGR2A_uc001gam.2_Missense_Mutation_p.G182V|FCGR2A_uc001gao.2_RNA	NM_001136219	NP_001129691	P12318	FCG2A_HUMAN	Fc fragment of IgG, low affinity IIa, receptor	183	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AGTCACAGTGGTGATTACCAC	0.498			NA											24	100					2.44723e-14	3.90543e-14	0.004656	1	0
FCRLA	84824	broad.mit.edu	37	1	161680550	161680550	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:161680550C>T	uc001gbe.2	+	3	391	c.149C>T	c.(148-150)GCT>GTT	p.A50V	FCRLA_uc001gbd.2_Missense_Mutation_p.A44V|FCRLA_uc001gbf.2_Missense_Mutation_p.A44V|FCRLA_uc001gbg.2_Intron|FCRLA_uc009wuo.2_Intron|FCRLA_uc009wup.2_Missense_Mutation_p.A44V|FCRLA_uc009wuq.2_Intron	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			CCCTCTTCAGCTGCCAGTTTT	0.527			NA											4	60					0	0	0.000602	0	0
NOS1AP	9722	broad.mit.edu	37	1	162337164	162337164	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:162337164C>A	uc001gbv.2	+	10	1815	c.1428C>A	c.(1426-1428)CGC>CGA	p.R476R	NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_Silent_p.R471R|NOS1AP_uc009wut.1_Silent_p.R181R	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	476					regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			GCGAGGAGCGCGACTCGTGGT	0.657			NA											6	13					0.00116845	0.0012964	0.001168	1	0
LMX1A	4009	broad.mit.edu	37	1	165173231	165173231	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:165173231G>A	uc001gcy.1	-	8	1256	c.1035C>T	c.(1033-1035)CTC>CTT	p.L345L	LMX1A_uc001gcz.1_Silent_p.L345L|LMX1A_uc001gcw.1_Silent_p.L63L|LMX1A_uc001gcx.1_Silent_p.L96L	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	345						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					CCAGGTTACTGAGGGAGGTGT	0.507			NA											8	114					0	0	0.004482	0	0
ILDR2	387597	broad.mit.edu	37	1	166892009	166892009	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:166892009C>A	uc001gdx.1	-	8	1088	c.1032G>T	c.(1030-1032)GAG>GAT	p.E344D		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	344	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						TGCTGTCCTCCTCATGTAGGG	0.468			NA											65	115					3.61411e-23	6.39739e-23	0.00361	1	0
DCAF6	55827	broad.mit.edu	37	1	167956802	167956802	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:167956802G>A	uc001gew.2	+	5	750	c.508G>A	c.(508-510)GAT>AAT	p.D170N	DCAF6_uc001gev.2_Missense_Mutation_p.D170N|DCAF6_uc001gex.2_Missense_Mutation_p.D170N|DCAF6_uc010plk.1_Missense_Mutation_p.D139N|DCAF6_uc001gey.2_Missense_Mutation_p.D23N	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	170	WD 3.				positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TAGGTGGTTTGATACACGCAT	0.303			NA											9	59					0	0	0.008291	0	0
FASLG	356	broad.mit.edu	37	1	172628540	172628540	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:172628540C>A	uc001gis.2	+	1	356	c.199C>A	c.(199-201)CCG>ACG	p.P67T	FASLG_uc001git.2_Missense_Mutation_p.P67T	NM_000639	NP_000630	P48023	TNFL6_HUMAN	fas ligand	67	Pro-rich.|Cytoplasmic (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			lung(2)|breast(1)	3						gcctccactaccgctgccacc	0.338	Ovarian(28;486 876 30334 44033)		NA											5	20					0.00116845	0.0012964	0.001168	1	0
ANKRD45	339416	broad.mit.edu	37	1	173594012	173594012	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:173594012G>C	uc001gja.1	-	5	705	c.644C>G	c.(643-645)ACA>AGA	p.T215R		NM_198493	NP_940895	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	231											0						GGAAGCTTCTGTATGGGTTTC	0.378			NA											6	72					0	0	0.001168	0	0
TNR	7143	broad.mit.edu	37	1	175372526	175372526	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:175372526C>A	uc001gkp.1	-	2	807	c.726G>T	c.(724-726)CGG>CGT	p.R242R	TNR_uc009wwu.1_Silent_p.R242R|TNR_uc010pmz.1_Silent_p.R242R	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	242	Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CGCAGAGCCCCCGGGAGCTGC	0.642			NA											39	44					1.30998e-17	2.20961e-17	0.005524	1	0
RFWD2	64326	broad.mit.edu	37	1	176105681	176105681	+	Silent	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:176105681T>C	uc001gku.1	-	7	1090	c.834A>G	c.(832-834)CAA>CAG	p.Q278Q	RFWD2_uc001gkv.1_Intron|RFWD2_uc001gkw.1_Silent_p.Q38Q|RFWD2_uc009wwv.2_Silent_p.Q38Q|RFWD2_uc001gkt.1_Intron	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	278	Potential.				DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						TCTGTTCCAGTTGCTGCAGAT	0.333	Ovarian(134;1413 1765 5706 35534 51541)		NA											9	25					0	0	0.008291	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564576	176564576	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:176564576C>G	uc001gkz.2	+	3	3000	c.1836C>G	c.(1834-1836)TGC>TGG	p.C612W	PAPPA2_uc001gky.1_Missense_Mutation_p.C612W|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	612	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GGGGTGACTGCCGCCTGCAGG	0.587			NA											4	77					0	0	0.001984	0	0
PAPPA2	60676	broad.mit.edu	37	1	176668331	176668331	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:176668331A>G	uc001gkz.2	+	8	4006	c.2842A>G	c.(2842-2844)ACA>GCA	p.T948A	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	948					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CCCCTGCCCCACAGAAGGCTG	0.612			NA											8	142					0	0	0.004482	0	0
PAPPA2	60676	broad.mit.edu	37	1	176679225	176679225	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:176679225G>C	uc001gkz.2	+	11	4728	c.3564G>C	c.(3562-3564)TTG>TTC	p.L1188F	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1188					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AAGGATACTTGGATCAATGGG	0.453			NA											39	97					0	0	0.007835	0	0
PAPPA2	60676	broad.mit.edu	37	1	176769207	176769207	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:176769207G>T	uc001gkz.2	+	21	6305	c.5141G>T	c.(5140-5142)TGC>TTC	p.C1714F	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1714	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AGCATTGTGTGCACTGGCCGG	0.502			NA											16	232					1.67942e-08	2.29485e-08	0.006122	1	0
FAM5B	57795	broad.mit.edu	37	1	177250431	177250432	+	Missense_Mutation	DNP	CC	CC	AG			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:177250431_177250432CC>AG	uc001glf.2	+	8	2431_2432	c.2119_2120CC>AG	c.(2119-2121)CCA>AGA	p.P707R	FAM5B_uc001glg.2_Missense_Mutation_p.P602R	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	707						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						GTTGGACTACCCATATACTCAA	0.5			NA											55	159					0	0	0.004672	0	0
TOR3A	64222	broad.mit.edu	37	1	179054768	179054768	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:179054768G>A	uc001gmd.2	+	3	531	c.379G>A	c.(379-381)GAG>AAG	p.E127K	TOR3A_uc010pnd.1_Intron	NM_022371	NP_071766	Q9H497	TOR3A_HUMAN	torsin family 3, member A precursor	127					chaperone mediated protein folding requiring cofactor	endoplasmic reticulum	ATP binding			pancreas(1)	1						CTTAGGCTTAGAGTGGGACCT	0.542			NA											17	287					0	0	0.00499	0	0
C1orf125	126859	broad.mit.edu	37	1	179339140	179339140	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:179339140T>C	uc001gmo.2	+	4	428	c.301T>C	c.(301-303)TGG>CGG	p.W101R	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmn.1_5'UTR|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.W101R	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	101											0						AGACCATGTCTGGCATCACCC	0.423			NA											6	43					0	0	0.001168	0	0
QSOX1	5768	broad.mit.edu	37	1	180159623	180159623	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:180159623A>G	uc001gnz.2	+	10	1271	c.1196A>G	c.(1195-1197)CAT>CGT	p.H399R	QSOX1_uc001gny.2_Missense_Mutation_p.H399R|QSOX1_uc001goa.2_Missense_Mutation_p.H399R	NM_002826	NP_002817	O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1 isoform a	399	ERV/ALR sulfhydryl oxidase.				cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			ovary(1)|central_nervous_system(1)	2						AGTGAGCCGCATTTCCGGGGC	0.562			NA											71	122					0	0	0.00361	0	0
KIAA1614	57710	broad.mit.edu	37	1	180885948	180885948	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:180885948A>T	uc001gok.2	+	2	776	c.709A>T	c.(709-711)AGG>TGG	p.R237W		NM_020950	NP_066001	Q5VZ46	K1614_HUMAN	hypothetical protein LOC57710	237										ovary(3)|skin(1)	4						TCCCAGCCCAAGGACAGGAAG	0.582			NA											83	167					0	0	0.00361	0	0
ZNF648	127665	broad.mit.edu	37	1	182026091	182026091	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:182026091T>A	uc001goz.2	-	2	1263	c.1055A>T	c.(1054-1056)AAA>ATA	p.K352I		NM_001009992	NP_001009992	Q5T619	ZN648_HUMAN	zinc finger protein 648	352	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GCGCTGGTGTTTGCGCAGGTC	0.637	NSCLC(71;908 1374 5429 20458 35642)		NA											6	27					0	0	0.001984	0	0
HMCN1	83872	broad.mit.edu	37	1	186031015	186031015	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:186031015A>G	uc001grq.1	+	47	7574	c.7345A>G	c.(7345-7347)ATG>GTG	p.M2449V		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2449	Ig-like C2-type 22.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GCAGACCACAATGGAAGATGC	0.383			NA											18	105					0	0	0.008871	0	0
FAM5C	339479	broad.mit.edu	37	1	190067407	190067407	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:190067407C>A	uc001gse.1	-	8	2274	c.2042G>T	c.(2041-2043)CGG>CTG	p.R681L	FAM5C_uc010pot.1_Missense_Mutation_p.R579L	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	681						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					AATCAGGTCCCGAATTGCTTC	0.458			NA											62	90					1.50372e-20	2.5932e-20	0.00361	1	0
FAM5C	339479	broad.mit.edu	37	1	190067891	190067891	+	Missense_Mutation	SNP	G	G	T	rs147799875		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:190067891G>T	uc001gse.1	-	8	1790	c.1558C>A	c.(1558-1560)CGC>AGC	p.R520S	FAM5C_uc010pot.1_Missense_Mutation_p.R418S	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	520						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					CTATTGAGGCGCATGTCATTG	0.453			NA											15	170					3.45872e-05	4.11307e-05	0.004007	1	0
FAM5C	339479	broad.mit.edu	37	1	190250803	190250803	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:190250803G>C	uc001gse.1	-	3	546	c.314C>G	c.(313-315)CCT>CGT	p.P105R	FAM5C_uc010pot.1_Intron	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	105						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GAAGAATTCAGGGGCAAGAGG	0.413			NA											15	68					0	0	0.004007	0	0
KCNT2	343450	broad.mit.edu	37	1	196448362	196448362	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:196448362C>G	uc001gtd.1	-	5	391	c.331G>C	c.(331-333)GTG>CTG	p.V111L	KCNT2_uc001gte.1_Missense_Mutation_p.V111L|KCNT2_uc001gtf.1_Missense_Mutation_p.V111L|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.V111L|KCNT2_uc009wyv.1_Missense_Mutation_p.V111L	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	111	Helical; Name=Segment S2; (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						ATCAATGCCACTGAAACCTGA	0.274			NA											10	27					0	0	0.008291	0	0
F13B	2165	broad.mit.edu	37	1	197026157	197026157	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:197026157G>C	uc001gtt.1	-	7	1201	c.1157C>G	c.(1156-1158)CCT>CGT	p.P386R		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	386	Sushi 6.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						ACACTCAGGAGGAAGTGTCCA	0.358			NA											7	71					0	0	0.001984	0	0
F13B	2165	broad.mit.edu	37	1	197026458	197026458	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:197026458G>T	uc001gtt.1	-	6	987	c.943C>A	c.(943-945)CGT>AGT	p.R315S		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	315	Sushi 5.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TCTTCACAACGTATTTCTGCT	0.353			NA											32	142					3.90053e-15	6.34299e-15	0.002445	1	0
CRB1	23418	broad.mit.edu	37	1	197446847	197446847	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:197446847C>T	uc001gtz.2	+	12	4194	c.4059C>T	c.(4057-4059)GTC>GTT	p.V1353V	CRB1_uc010poz.1_Silent_p.V1329V|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Silent_p.V1241V|CRB1_uc010ppb.1_Silent_p.V817V|CRB1_uc010ppd.1_Silent_p.V834V	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	1353	Helical; (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						CAGTGACTGTCGCCTTGTTAC	0.483			NA											6	76					0	0	0.001168	0	0
PTPRC	5788	broad.mit.edu	37	1	198668730	198668730	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:198668730C>G	uc001gur.1	+	5	510	c.330C>G	c.(328-330)CAC>CAG	p.H110Q	PTPRC_uc001gus.1_Missense_Mutation_p.H110Q|PTPRC_uc001gut.1_Intron|PTPRC_uc009wze.1_Missense_Mutation_p.H46Q|PTPRC_uc009wzf.1_Missense_Mutation_p.H46Q|PTPRC_uc010ppg.1_Missense_Mutation_p.H46Q|PTPRC_uc001guu.1_Missense_Mutation_p.H153Q|PTPRC_uc001guv.1_RNA|PTPRC_uc001guw.1_RNA	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	110	Extracellular (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TTCCCACGCACGCAGACTCGC	0.517			NA									OREG0014061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	158					0	0	0.000978	0	0
LGR6	59352	broad.mit.edu	37	1	202288240	202288240	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:202288240C>G	uc001gxu.2	+	18	2809	c.2809C>G	c.(2809-2811)CTG>GTG	p.L937V	LGR6_uc001gxv.2_Missense_Mutation_p.L885V|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Missense_Mutation_p.L798V	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	937	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						TGGAGAACTGCTGCTGAGGGC	0.612			NA											18	63					0	0	0.008871	0	0
PPFIA4	8497	broad.mit.edu	37	1	203008326	203008326	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:203008326G>T	uc009xaj.2	+	6	631	c.631G>T	c.(631-633)GAG>TAG	p.E211*				O75335	LIPA4_HUMAN	SubName: Full=Liprin alpha4;	Error:Variant_position_missing_in_O75335_after_alignment					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						TGCCATACACGAGCGGGACCA	0.627			NA									OREG0014109	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	11					1.23904e-05	1.49305e-05	0.000602	1	0
PPP1R15B	84919	broad.mit.edu	37	1	204379011	204379011	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:204379011G>A	uc001hav.3	-	1	1934	c.1529C>T	c.(1528-1530)TCA>TTA	p.S510L		NM_032833	NP_116222	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	510					regulation of translation					ovary(1)|pancreas(1)	2	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			ATCCTTCTCTGAATCAGAAGG	0.468			NA											9	91					0	0	0.006214	0	0
PPP1R15B	84919	broad.mit.edu	37	1	204379097	204379097	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:204379097G>C	uc001hav.3	-	1	1848	c.1443C>G	c.(1441-1443)TTC>TTG	p.F481L		NM_032833	NP_116222	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	481					regulation of translation					ovary(1)|pancreas(1)	2	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			CTACACTGCAGAAAGAGTTCC	0.448			NA											11	160					0	0	0.001368	0	0
NUCKS1	64710	broad.mit.edu	37	1	205688745	205688745	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:205688745T>G	uc001hdb.2	-	6	702	c.442A>C	c.(442-444)AGT>CGT	p.S148R		NM_022731	NP_073568	Q9H1E3	NUCKS_HUMAN	nuclear casein kinase and cyclin-dependent	148						nucleus					0	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			TTTTTCGAACTGCCATAGTCA	0.363			NA											43	61					0	0	0.003214	0	0
AVPR1B	553	broad.mit.edu	37	1	206224651	206224651	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:206224651C>A	uc001hds.2	+	1	369	c.211C>A	c.(211-213)CTG>ATG	p.L71M		NM_000707	NP_000698	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	71	Cytoplasmic (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			ovary(2)|large_intestine(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	CCGCATGCACCTGTTCGTGCT	0.677			NA											26	40					1.17739e-12	1.80596e-12	0.005443	1	0
LAMB3	3914	broad.mit.edu	37	1	209799050	209799050	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:209799050C>G	uc001hhg.2	-	13	2309	c.1919G>C	c.(1918-1920)AGC>ACC	p.S640T	LAMB3_uc009xco.2_Missense_Mutation_p.S640T|LAMB3_uc001hhh.2_Missense_Mutation_p.S640T|LAMB3_uc010psl.1_Intron|hsa-mir-4260|MI0015859_5'Flank	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	640	Domain II.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GACTGCGGGGCTGCTGAGAAC	0.592			NA											56	87					0	0	0.00361	0	0
KCNH1	3756	broad.mit.edu	37	1	211192227	211192227	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:211192227G>A	uc001hib.2	-	6	1100	c.930C>T	c.(928-930)AAC>AAT	p.N310N	KCNH1_uc001hic.2_Silent_p.N310N	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	310	Helical; Name=Segment S3; (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		TCTCAAAAGCGTTGATGACAT	0.483			NA											38	181					0	0	0.00623	0	0
RD3	343035	broad.mit.edu	37	1	211654573	211654573	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:211654573C>A	uc001him.2	-	2	1349	c.185G>T	c.(184-186)TGG>TTG	p.W62L	RD3_uc001hin.2_RNA|RD3_uc009xda.2_Intron	NM_183059	NP_898882	Q7Z3Z2	RD3_HUMAN	retinal degeneration 3	62					response to stimulus|visual perception					ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00284)|all cancers(67;0.0279)|Epithelial(68;0.0689)		GCTGGCCAGCCAGCTGTAGTC	0.602			NA											5	99					8.12818e-05	9.43997e-05	0.001984	1	0
USH2A	7399	broad.mit.edu	37	1	215953232	215953232	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:215953232C>A	uc001hku.1	-	55	11279	c.10892G>T	c.(10891-10893)GGT>GTT	p.G3631V		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3631	Extracellular (Potential).|Fibronectin type-III 21.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTGGATGAGACCTTTCCCAAC	0.483			NA								HNSCC(13;0.011)			36	99					4.32679e-17	7.24267e-17	0.006999	1	0
USH2A	7399	broad.mit.edu	37	1	216040371	216040371	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:216040371G>A	uc001hku.1	-	44	9210	c.8823C>T	c.(8821-8823)ATC>ATT	p.I2941I		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2941	Fibronectin type-III 16.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACCTCACGTCGATGGCTGTGT	0.453			NA								HNSCC(13;0.011)			9	102					0	0	0.001855	0	0
USH2A	7399	broad.mit.edu	37	1	216420110	216420110	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:216420110C>A	uc001hku.1	-	13	3013	c.2626G>T	c.(2626-2628)GGT>TGT	p.G876C	USH2A_uc001hkv.2_Missense_Mutation_p.G876C	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	876	Laminin EGF-like 7.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CAGCGAAGACCTGTTACCCCT	0.448			NA								HNSCC(13;0.011)			39	225					4.90274e-10	7.06288e-10	0.00623	1	0
CDC42BPA	8476	broad.mit.edu	37	1	227348290	227348290	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:227348290C>G	uc001hqr.2	-	6	1590	c.647G>C	c.(646-648)CGG>CCG	p.R216P	CDC42BPA_uc001hqs.2_Missense_Mutation_p.R216P|CDC42BPA_uc009xes.2_Missense_Mutation_p.R216P|CDC42BPA_uc010pvs.1_Missense_Mutation_p.R216P	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	216	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				ATCTGCTAACCGAATATGTCC	0.294			NA											24	193					0	0	0.007291	0	0
WNT9A	7483	broad.mit.edu	37	1	228109636	228109636	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:228109636C>A	uc001hri.2	-	4	769	c.681G>T	c.(679-681)CGG>CGT	p.R227R		NM_003395	NP_003386	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family,	227					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			central_nervous_system(1)|pancreas(1)	2		Prostate(94;0.0405)				GCCAGCAGGTCCGCACCGTGC	0.622			NA											30	63					5.6714e-07	7.2783e-07	0.002096	1	0
OBSCN	84033	broad.mit.edu	37	1	228481254	228481254	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:228481254G>T	uc009xez.1	+	41	11112	c.11068G>T	c.(11068-11070)GAC>TAC	p.D3690Y	OBSCN_uc001hsn.2_Missense_Mutation_p.D3690Y|OBSCN_uc001hsq.1_Missense_Mutation_p.D946Y	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3690	Ig-like 37.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CGTGGCAGAGGACGCTGGGGA	0.632			NA											37	64					2.19489e-29	4.04806e-29	0.00623	1	0
GALNT2	2590	broad.mit.edu	37	1	230415090	230415090	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:230415090G>T	uc010pwa.1	+	16	1674	c.1602G>T	c.(1600-1602)GTG>GTT	p.V534V	GALNT2_uc010pvy.1_Silent_p.V496V|GALNT2_uc001htu.2_Silent_p.V146V	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	534	Lumenal (Potential).|Ricin B-type lectin.				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				TGAGGCACGTGGGCAGCAACC	0.587			NA											24	58					0.000295444	0.000335533	0.002299	1	0
TRIM67	440730	broad.mit.edu	37	1	231344888	231344888	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:231344888G>T	uc009xfn.1	+	8	2057	c.2015G>T	c.(2014-2016)AGG>ATG	p.R672M		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	tripartite motif-containing 67	672	B30.2/SPRY.					cytoplasm|cytoskeleton	zinc ion binding			ovary(2)|breast(1)|kidney(1)	4	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				GGGGTGGCCAGGGCCAGCGTG	0.627			NA											19	101					3.51602e-12	5.35046e-12	0.008871	1	0
PCNXL2	80003	broad.mit.edu	37	1	233296137	233296138	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:233296137_233296138CC>AA	uc001hvl.2	-	19	3643_3644	c.3408_3409GG>TT	c.(3406-3411)GTGGGG>GTTTGG	p.G1137W	PCNXL2_uc001hvm.1_RNA|PCNXL2_uc009xfu.2_RNA|PCNXL2_uc001hvp.1_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1137	Helical; (Potential).					integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				GTTACAAACCCCACGGCTCCAG	0.5			NA											16	60					0	0	0.004672	0	0
LYST	1130	broad.mit.edu	37	1	235945360	235945360	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:235945360C>A	uc001hxj.2	-	15	5065	c.4890G>T	c.(4888-4890)ATG>ATT	p.M1630I	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	1630					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTCTTGGAAGCATAAAATCCA	0.318			NA							Chediak-Higashsyndrome				14	30					1.49906e-05	1.79654e-05	0.00245	1	0
RYR2	6262	broad.mit.edu	37	1	237550647	237550647	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:237550647G>T	uc001hyl.1	+	9	763	c.643G>T	c.(643-645)GCC>TCC	p.A215S		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	215	Cytoplasmic (By similarity).|MIR 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTGGAGCGTGGCCCCAATCAG	0.507			NA											46	104					1.32667e-27	2.4207e-27	0.00361	1	0
RYR2	6262	broad.mit.edu	37	1	237732489	237732489	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:237732489G>T	uc001hyl.1	+	29	3588	c.3468G>T	c.(3466-3468)TGG>TGT	p.W1156C		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1156	Cytoplasmic (By similarity).|4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGCGCTCTTGGCAAGCAGGCG	0.507			NA											6	54					8.12818e-05	9.43997e-05	0.001984	1	0
RYR2	6262	broad.mit.edu	37	1	237777418	237777418	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:237777418G>C	uc001hyl.1	+	37	5110	c.4990G>C	c.(4990-4992)GTC>CTC	p.V1664L		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1664	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTACTCAGCCGTCTGTGCTCT	0.517			NA											29	51					0	0	0.009535	0	0
RYR2	6262	broad.mit.edu	37	1	237944872	237944872	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:237944872G>T	uc001hyl.1	+	89	12008	c.11888G>T	c.(11887-11889)AGT>ATT	p.S3963I	RYR2_uc010pya.1_Missense_Mutation_p.S378I	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3963					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAGGATTCCAGTCAAATTGAG	0.338			NA											9	7					4.68919e-08	6.2631e-08	0.008291	1	0
RYR2	6262	broad.mit.edu	37	1	237947327	237947327	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:237947327C>A	uc001hyl.1	+	90	12435	c.12315C>A	c.(12313-12315)CTC>CTA	p.L4105L	RYR2_uc010pya.1_Silent_p.L520L	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4105					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGACAAACCTCTCTGAGCACA	0.512			NA											9	42					0.00448238	0.00488872	0.004482	1	0
FMN2	56776	broad.mit.edu	37	1	240494014	240494014	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:240494014G>A	uc010pyd.1	+	11	4774	c.4549G>A	c.(4549-4551)GAC>AAC	p.D1517N	FMN2_uc010pye.1_Missense_Mutation_p.D1521N|FMN2_uc010pyf.1_Missense_Mutation_p.D163N|FMN2_uc010pyg.1_Missense_Mutation_p.D113N	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1517	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CTTTGGATTAGACATTCTTCC	0.433			NA											5	77					0	0	0.000602	0	0
CHML	1122	broad.mit.edu	37	1	241798993	241798993	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:241798993C>A	uc001hzd.2	-	1	240	c.76G>T	c.(76-78)GCA>TCA	p.A26S	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	26					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			CTTGAACATGCAGCTGCAAGG	0.453			NA											27	142					2.44723e-14	3.90543e-14	0.004656	1	0
NLRP3	114548	broad.mit.edu	37	1	247587718	247587718	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:247587718G>A	uc001icr.2	+	5	1111	c.973G>A	c.(973-975)GCC>ACC	p.A325T	NLRP3_uc001ics.2_Missense_Mutation_p.A325T|NLRP3_uc001icu.2_Missense_Mutation_p.A325T|NLRP3_uc001icw.2_Missense_Mutation_p.A325T|NLRP3_uc001icv.2_Missense_Mutation_p.A325T|NLRP3_uc010pyw.1_Missense_Mutation_p.A323T|NLRP3_uc001ict.1_Missense_Mutation_p.A323T	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	325	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CTGGCAGAAGGCCGAGCGGGG	0.572			NA											5	105					0	0	0.001168	0	0
NLRP3	114548	broad.mit.edu	37	1	247587916	247587916	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:247587916C>A	uc001icr.2	+	5	1309	c.1171C>A	c.(1171-1173)CAA>AAA	p.Q391K	NLRP3_uc001ics.2_Missense_Mutation_p.Q391K|NLRP3_uc001icu.2_Missense_Mutation_p.Q391K|NLRP3_uc001icw.2_Missense_Mutation_p.Q391K|NLRP3_uc001icv.2_Missense_Mutation_p.Q391K|NLRP3_uc010pyw.1_Missense_Mutation_p.Q389K|NLRP3_uc001ict.1_Missense_Mutation_p.Q389K	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	391	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TGATGAGGCCCAAGCCAGGGC	0.537			NA											25	46					4.72057e-08	6.2941e-08	0.003954	1	0
OR14A16	284532	broad.mit.edu	37	1	247978156	247978156	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:247978156C>A	uc001idm.1	-	1	876	c.876G>T	c.(874-876)AAG>AAT	p.K292N		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	292	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCTTTATGGCCTTGTTTCTCA	0.378	Ovarian(112;180 1586 15073 21914 33526)		NA											17	53					3.62473e-10	5.25126e-10	0.001882	1	0
OR14A16	284532	broad.mit.edu	37	1	247978337	247978337	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:247978337T>A	uc001idm.1	-	1	695	c.695A>T	c.(694-696)CAG>CTG	p.Q232L		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGCTTTTGACTGGCCTTCTGT	0.408	Ovarian(112;180 1586 15073 21914 33526)		NA											5	37					0	0	0.001984	0	0
OR2AK2	391191	broad.mit.edu	37	1	248128744	248128744	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:248128744G>C	uc010pzd.1	+	1	111	c.111G>C	c.(109-111)TGG>TGC	p.W37C	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	37	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			AATATGGCTGGATAAACTCTC	0.388	Melanoma(45;390 1181 23848 28461 41504)		NA											24	282					0	0	0.002299	0	0
OR2M2	391194	broad.mit.edu	37	1	248344254	248344254	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:248344254T>C	uc010pzf.1	+	1	967	c.967T>C	c.(967-969)TTT>CTT	p.F323L		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	323	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGTTTTGCTGTTTGCTAAATT	0.363			NA											21	296					0	0	0.001882	0	0
OR2M7	391196	broad.mit.edu	37	1	248487667	248487667	+	Silent	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:248487667G>C	uc010pzk.1	-	1	204	c.204C>G	c.(202-204)CTC>CTG	p.L68L		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGAGGTCCATGAGGGACAGTT	0.512			NA											62	452					0	0	0.00361	0	0
OR2T4	127074	broad.mit.edu	37	1	248525501	248525501	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:248525501C>T	uc001ieh.1	+	1	619	c.619C>T	c.(619-621)CAT>TAT	p.H207Y		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	207	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCGGGAGATTCATCATTTCTT	0.498			NA											29	270					0	0	0.00632	0	0
OR2T4	127074	broad.mit.edu	37	1	248525656	248525656	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:248525656C>G	uc001ieh.1	+	1	774	c.774C>G	c.(772-774)CAC>CAG	p.H258Q		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	258	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCACCATCCACGGGATGAACT	0.512			NA											29	203					0	0	0.008361	0	0
OR2T6	254879	broad.mit.edu	37	1	248551682	248551682	+	Missense_Mutation	SNP	C	C	T	rs141134612	by1000genomes	TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:248551682C>T	uc001iei.1	+	1	773	c.773C>T	c.(772-774)ACG>ATG	p.T258M		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	258	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCCTTGTATACGTATACGCTT	0.473			NA											21	83					0	0	0.008871	0	0
ADARB2	105	broad.mit.edu	37	10	1229175	1229175	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:1229175C>T	uc009xhq.2	-	10	2552	c.2178G>A	c.(2176-2178)GTG>GTA	p.V726V	uc001igj.1_5'Flank|ADARB2_uc009xhp.2_Silent_p.V110V|ADARB2_uc001igl.3_Silent_p.V88V|ADARB2_uc001igm.3_Silent_p.V235V	NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	726	A to I editase.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		GTGGTTTCCTCACCCAGGTGC	0.617			NA											7	21					0	0	0.001984	0	0
PRKCQ	5588	broad.mit.edu	37	10	6498661	6498661	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:6498661C>A	uc001ijj.1	-	15	1697	c.1622G>T	c.(1621-1623)GGG>GTG	p.G541V	PRKCQ_uc009xim.1_Missense_Mutation_p.G541V|PRKCQ_uc001iji.1_Missense_Mutation_p.G574V|PRKCQ_uc009xin.1_Missense_Mutation_p.G505V|PRKCQ_uc010qax.1_Missense_Mutation_p.G416V	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	541	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						GTCAGGTGTCCCACAGAAGGT	0.498	Ovarian(50;572 1126 10530 25349 30594)		NA											14	57					1.05317e-09	1.50035e-09	0.00245	1	0
GATA3	2625	broad.mit.edu	37	10	8100776	8100776	+	Silent	SNP	G	G	A	rs28395792		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:8100776G>A	uc001ika.2	+	3	1307	c.750G>A	c.(748-750)AAG>AAA	p.K250K	GATA3_uc001ijz.2_Silent_p.K250K	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	250					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						TCGGATGCAAGTCCAGGCCCA	0.667			NA	F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						15	38					0	0	0.007413	0	0
FAM107B	83641	broad.mit.edu	37	10	14816390	14816390	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:14816390C>A	uc001ina.1	-	1	507	c.273G>T	c.(271-273)CGG>CGT	p.R91R	FAM107B_uc010qbu.1_RNA	NM_031453	NP_113641	Q9H098	F107B_HUMAN	hypothetical protein LOC83641	Error:Variant_position_missing_in_Q9H098_after_alignment										breast(4)	4						GACTTGAATTCCGATTCGCAC	0.592			NA											34	197					2.40579e-17	4.04909e-17	0.00623	1	0
DCLRE1C	64421	broad.mit.edu	37	10	14974866	14974866	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:14974866C>A	uc001inn.2	-	9	852	c.767G>T	c.(766-768)TGC>TTC	p.C256F	DCLRE1C_uc010qbx.1_Missense_Mutation_p.C256F|DCLRE1C_uc001inl.2_Missense_Mutation_p.C136F|DCLRE1C_uc009xji.2_Missense_Mutation_p.C141F|DCLRE1C_uc001inm.2_Missense_Mutation_p.C136F|DCLRE1C_uc001ino.2_Missense_Mutation_p.C141F|DCLRE1C_uc009xjh.2_RNA|DCLRE1C_uc001inp.2_Missense_Mutation_p.C136F|DCLRE1C_uc001inq.2_Missense_Mutation_p.C136F|DCLRE1C_uc001inr.2_Missense_Mutation_p.C141F|DCLRE1C_uc009xjj.1_RNA	NM_001033855	NP_001029027	Q96SD1	DCR1C_HUMAN	artemis protein isoform a	256					DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)	1						GGGATGCCGGCATGCATGGAT	0.438			NA						Involved_in_tolerance_or_repair_of_DNA_crosslinks|NHEJ					63	168					6.00099e-30	1.10943e-29	0.00361	1	0
CUBN	8029	broad.mit.edu	37	10	16990513	16990513	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:16990513C>T	uc001ioo.2	-	35	5225	c.5173G>A	c.(5173-5175)GGG>AGG	p.G1725R		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1725	CUB 11.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGGAAACCCCCAGCACTGATG	0.512			NA											7	43					0	0	0.001984	0	0
ST8SIA6	338596	broad.mit.edu	37	10	17369028	17369028	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:17369028G>T	uc001ipd.2	-	6	620	c.620C>A	c.(619-621)TCC>TAC	p.S207Y	ST8SIA6_uc010qce.1_Intron	NM_001004470	NP_001004470	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide	207	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(1)	1						AACGAAGTCGGATTTATCTAT	0.393			NA											16	53					1.67942e-08	2.29485e-08	0.006122	1	0
SLC39A12	221074	broad.mit.edu	37	10	18242230	18242230	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:18242230G>T	uc001ipo.2	+	2	298	c.25G>T	c.(25-27)GTA>TTA	p.V9L	SLC39A12_uc001ipn.2_Missense_Mutation_p.V9L|SLC39A12_uc001ipp.2_Missense_Mutation_p.V9L|SLC39A12_uc010qck.1_Intron	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	9	Extracellular (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						AAAGCTCTCAGTATCCTGGGT	0.507			NA											38	81					8.73648e-17	1.45766e-16	0.004289	1	0
CACNB2	783	broad.mit.edu	37	10	18439905	18439905	+	Splice_Site	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:18439905G>T	uc001ipr.2	+	2	273	c.213_splice	c.e2+1	p.Q71_splice	CACNB2_uc009xjz.1_Splice_Site_p.Q71_splice|CACNB2_uc001ips.2_Splice_Site_p.Q71_splice|CACNB2_uc001ipt.2_Splice_Site_p.Q71_splice|CACNB2_uc010qcl.1_Splice_Site|CACNB2_uc001ipu.2_Splice_Site_p.Q43_splice|CACNB2_uc001ipv.2_Splice_Site_p.Q43_splice|CACNB2_uc009xka.1_Splice_Site_p.Q43_splice	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2						axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TGTTCGCCAGGTAAGAGTTTT	0.328			NA											32	109					1.62565e-12	2.48609e-12	0.002445	1	0
SPAG6	9576	broad.mit.edu	37	10	22680766	22680766	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:22680766C>A	uc001iri.2	+	8	1256	c.1114C>A	c.(1114-1116)CGG>AGG	p.R372R	SPAG6_uc001irj.2_Silent_p.R372R|SPAG6_uc010qct.1_Silent_p.R342R|SPAG6_uc009xkh.2_Silent_p.R350R	NM_012443	NP_036575	O75602	SPAG6_HUMAN	sperm associated antigen 6 isoform 1	372	ARM 8.				cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(1)	1						TGAACACGCACGGGCTGTTGC	0.453			NA											22	68					8.10497e-08	1.07323e-07	0.010504	1	0
ARHGAP21	57584	broad.mit.edu	37	10	24910126	24910126	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:24910126C>A	uc001isb.2	-	9	1185	c.698G>T	c.(697-699)AGT>ATT	p.S233I	ARHGAP21_uc010qdb.1_RNA|ARHGAP21_uc009xkl.1_Missense_Mutation_p.S233I|ARHGAP21_uc010qdc.1_Missense_Mutation_p.S68I|ARHGAP21_uc001isc.1_Missense_Mutation_p.S223I	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	232					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						TACTGGTGTACTGGTTTGCTG	0.483			NA											8	105					1.12685e-05	1.36427e-05	0.004482	1	0
GPR158	57512	broad.mit.edu	37	10	25887045	25887045	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:25887045G>T	uc001isj.2	+	11	2550	c.2490G>T	c.(2488-2490)GAG>GAT	p.E830D	GPR158_uc001isk.2_Missense_Mutation_p.E205D	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	830	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						AAACGGAAGAGTCCAGTAGCC	0.463			NA											37	132					1.49673e-21	2.61038e-21	0.00623	1	0
MYO3A	53904	broad.mit.edu	37	10	26457663	26457663	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:26457663T>A	uc001isn.2	+	28	3494	c.3134T>A	c.(3133-3135)GTG>GAG	p.V1045E	MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1045					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						TATTATCACGTGGAGCAGTTA	0.348			NA											6	76					0	0	0.001984	0	0
GAD2	2572	broad.mit.edu	37	10	26518625	26518625	+	Silent	SNP	C	C	A	rs145045666		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:26518625C>A	uc001isp.2	+	7	1262	c.759C>A	c.(757-759)ATC>ATA	p.I253I	GAD2_uc001isq.2_Silent_p.I253I	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	253					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding	p.I253I(1)		central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	CCATGATGATCGCACGCTTTA	0.428			NA											11	53					1.08611e-07	1.42471e-07	0.000978	1	0
SVIL	6840	broad.mit.edu	37	10	29784046	29784046	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:29784046G>A	uc001iut.1	-	19	4482	c.3729C>T	c.(3727-3729)ACC>ACT	p.T1243T	SVIL_uc010qdw.1_Silent_p.T157T|SVIL_uc001iuu.1_Silent_p.T817T|SVIL_uc009xlc.2_Silent_p.T35T	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1243					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				AAACGGGTGTGGTGCCTCTTG	0.552			NA											8	31					0	0	0.001368	0	0
SVIL	6840	broad.mit.edu	37	10	29812503	29812503	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:29812503C>T	uc001iut.1	-	15	3793	c.3040G>A	c.(3040-3042)GAA>AAA	p.E1014K	SVIL_uc010qdw.1_5'Flank|SVIL_uc001iuu.1_Missense_Mutation_p.E588K	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1014					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				TCCTTCGGTTCATCCCCGAGG	0.512			NA											7	64					0	0	0.001984	0	0
ZEB1	6935	broad.mit.edu	37	10	31750000	31750000	+	Silent	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:31750000A>G	uc001ivs.3	+	2	156	c.93A>G	c.(91-93)TCA>TCG	p.S31S	ZEB1_uc001ivr.3_5'UTR|ZEB1_uc010qee.1_5'UTR|ZEB1_uc010qef.1_5'UTR|ZEB1_uc009xlh.1_RNA|ZEB1_uc009xli.1_RNA|ZEB1_uc009xlj.1_Silent_p.S31S|ZEB1_uc010qeg.1_Intron|ZEB1_uc009xlk.1_5'UTR|ZEB1_uc001ivt.3_5'UTR|ZEB1_uc001ivu.3_Silent_p.S31S|ZEB1_uc001ivv.3_Silent_p.S31S|ZEB1_uc010qeh.1_Intron|ZEB1_uc009xll.2_RNA|ZEB1_uc009xlm.1_RNA|ZEB1_uc009xln.1_RNA|ZEB1_uc009xlo.1_Silent_p.S14S|ZEB1_uc009xlp.2_Silent_p.S14S	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	31					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				AAACAAATTCAGATTCAGATG	0.353	Ovarian(40;423 959 14296 36701 49589)		NA											12	23					0	0	0.001855	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37486372	37486372	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:37486372G>A	uc001iza.1	+	29	2611	c.2512G>A	c.(2512-2514)GCC>ACC	p.A838T		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	894						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						TCCAAATAAAGCCTTGGAATT	0.313			NA											26	128					0	0	0.009535	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508538	37508538	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:37508538C>A	uc001iza.1	+	34	3829	c.3730C>A	c.(3730-3732)CAC>AAC	p.H1244N		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1300	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GGAAGCTGAACACATGTATCA	0.368			NA											8	25					3.09899e-07	3.99367e-07	0.004482	1	0
HSD17B7P2	158160	broad.mit.edu	37	10	38647334	38647334	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:38647334G>T	uc010qex.1	+	2	205	c.130G>T	c.(130-132)GTC>TTC	p.V44F	HSD17B7P2_uc001izq.2_RNA|HSD17B7P2_uc010qew.1_Missense_Mutation_p.V44F|HSD17B7P2_uc001izo.1_RNA|HSD17B7P2_uc001izp.1_Missense_Mutation_p.V44F					SubName: Full=cDNA FLJ60462, highly similar to 3-keto-steroid reductase (EC 1.1.1.270);												0						GGCAGAAGCTGTCTGTGCTGC	0.577			NA											8	54					0.00307968	0.0033804	0.00308	1	0
BMS1	9790	broad.mit.edu	37	10	43287086	43287086	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:43287086G>T	uc001jaj.2	+	6	1006	c.648G>T	c.(646-648)CTG>CTT	p.L216L		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	216					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						GTGCCAAGCTGTTCTACCTTT	0.338			NA											23	109					1.87028e-06	2.35121e-06	0.001882	1	0
CSGALNACT2	55454	broad.mit.edu	37	10	43650913	43650913	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:43650913G>T	uc001jan.2	+	2	651	c.316G>T	c.(316-318)GGC>TGC	p.G106C	CSGALNACT2_uc001jam.1_Missense_Mutation_p.G106C	NM_018590	NP_061060	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate	106	Lumenal (Potential).				chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			ovary(1)	1						AGGGGCTAATGGCATAGGCTA	0.418			NA											7	43					1.6384e-10	2.4007e-10	0.001984	1	0
GPRIN2	9721	broad.mit.edu	37	10	46999701	46999701	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:46999701A>C	uc001jec.2	+	3	956	c.821A>C	c.(820-822)CAT>CCT	p.H274P	GPRIN2_uc010qfq.1_Missense_Mutation_p.H37P	NM_014696	NP_055511	O60269	GRIN2_HUMAN	G protein-regulated inducer of neurite outgrowth	274											0						CAGGCTCAGCATGGGGTGAAG	0.632			NA											4	83					0	0	0.009096	0	0
C10orf71	118461	broad.mit.edu	37	10	50531576	50531576	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:50531576C>A	uc010qgp.1	+	3	1325	c.986C>A	c.(985-987)GCC>GAC	p.A329D		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	329											0						CAGGTCCAGGCCAGCTGCAGT	0.582			NA											14	44					1.49906e-05	1.79654e-05	0.00245	1	0
PCDH15	65217	broad.mit.edu	37	10	56138610	56138610	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:56138610A>T	uc001jju.1	-	4	645	c.250T>A	c.(250-252)TGG>AGG	p.W84R	PCDH15_uc010qhq.1_Missense_Mutation_p.W89R|PCDH15_uc010qhr.1_Missense_Mutation_p.W84R|PCDH15_uc010qhs.1_Missense_Mutation_p.W89R|PCDH15_uc010qht.1_Missense_Mutation_p.W84R|PCDH15_uc010qhu.1_Missense_Mutation_p.W84R|PCDH15_uc001jjv.1_Missense_Mutation_p.W62R|PCDH15_uc010qhv.1_Missense_Mutation_p.W84R|PCDH15_uc010qhw.1_Missense_Mutation_p.W84R|PCDH15_uc010qhx.1_Missense_Mutation_p.W84R|PCDH15_uc010qhy.1_Missense_Mutation_p.W89R|PCDH15_uc010qhz.1_Missense_Mutation_p.W84R|PCDH15_uc010qia.1_Missense_Mutation_p.W62R|PCDH15_uc010qib.1_Missense_Mutation_p.W62R|PCDH15_uc001jjw.2_Missense_Mutation_p.W84R	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	84	Cadherin 1.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ATCAACACCCAGTAATCCACA	0.428			NA								HNSCC(58;0.16)			41	141					0	0	0.002522	0	0
BICC1	80114	broad.mit.edu	37	10	60577388	60577388	+	Missense_Mutation	SNP	G	G	A	rs141599424		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:60577388G>A	uc001jki.1	+	19	2600	c.2600G>A	c.(2599-2601)TGT>TAT	p.C867Y		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	867					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						AGCAATGGCTGTAACTTAAAT	0.468			NA											16	47					0	0	0.003163	0	0
MYPN	84665	broad.mit.edu	37	10	69881444	69881444	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:69881444C>G	uc001jnm.3	+	3	434	c.249C>G	c.(247-249)ATC>ATG	p.I83M	MYPN_uc001jnl.1_Missense_Mutation_p.I83M|MYPN_uc001jnn.3_Intron|MYPN_uc001jno.3_Missense_Mutation_p.I83M|MYPN_uc001jnp.1_Missense_Mutation_p.I83M|MYPN_uc009xps.2_Missense_Mutation_p.I83M|MYPN_uc009xpt.2_Missense_Mutation_p.I83M|MYPN_uc010qit.1_Translation_Start_Site|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	83	Interaction with CARP.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						GACTGGCCATCAATTACGACC	0.448			NA											11	42					0	0	0.000978	0	0
TET1	80312	broad.mit.edu	37	10	70332962	70332962	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:70332962C>A	uc001jok.3	+	2	1372	c.867C>A	c.(865-867)CCC>CCA	p.P289P		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	289					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						ACCTGGATCCCATTAAAAGTG	0.438			NA											16	91					1.99824e-07	2.59686e-07	0.00499	1	0
HKDC1	80201	broad.mit.edu	37	10	71025520	71025520	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:71025520A>T	uc001jpf.3	+	17	2685	c.2552A>T	c.(2551-2553)GAG>GTG	p.E851V	HKDC1_uc010qje.1_Missense_Mutation_p.E714V|HKDC1_uc009xqb.2_RNA	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	851					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						CAGGGGCTAGAGCACCTGAGG	0.662			NA											6	25					0	0	0.001168	0	0
NRG3	10718	broad.mit.edu	37	10	84118550	84118550	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:84118550G>T	uc001kco.2	+	2	906	c.879G>T	c.(877-879)AAG>AAT	p.K293N	NRG3_uc010qlz.1_Missense_Mutation_p.K293N|NRG3_uc001kcp.2_Missense_Mutation_p.K72N|NRG3_uc001kcq.2_Translation_Start_Site	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	293	EGF-like.|Extracellular (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		GCCGAGACAAGGACCTTGCAT	0.517			NA											19	71					2.4624e-09	3.4631e-09	0.008871	1	0
NRG3	10718	broad.mit.edu	37	10	84498377	84498377	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:84498377C>A	uc001kco.2	+	3	1025	c.998C>A	c.(997-999)CCG>CAG	p.P333Q	NRG3_uc010qlz.1_Missense_Mutation_p.P333Q|NRG3_uc001kcp.2_Missense_Mutation_p.P112Q|NRG3_uc001kcq.2_5'UTR	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	333	Extracellular (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		CAATTTCTGCCGAAAACTGAT	0.398			NA											16	51					1.99824e-07	2.59686e-07	0.00499	1	0
LIPN	643418	broad.mit.edu	37	10	90537778	90537778	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:90537778A>T	uc010qmw.1	+	9	976	c.976A>T	c.(976-978)ATA>TTA	p.I326L		NM_001102469	NP_001095939	Q5VXI9	LIPN_HUMAN	lipase-like, ab-hydrolase domain containing 4	326					lipid catabolic process	extracellular region	hydrolase activity				0		Colorectal(252;0.0161)		Colorectal(12;4.83e-05)|COAD - Colon adenocarcinoma(12;6.5e-05)		TCATCCCCCTATATATGACCT	0.488			NA											8	44					0	0	0.00308	0	0
PCGF5	84333	broad.mit.edu	37	10	93011157	93011157	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:93011157G>A	uc001khh.2	+	6	681	c.434G>A	c.(433-435)TGT>TAT	p.C145Y	PCGF5_uc010qnk.1_Missense_Mutation_p.C145Y|PCGF5_uc001khi.2_Missense_Mutation_p.C145Y	NM_032373	NP_115749	Q86SE9	PCGF5_HUMAN	polycomb group ring finger 5	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|PcG protein complex	zinc ion binding			lung(1)	1						TGTCTAGATTGTTTACGAAAT	0.338	Colon(178;732 2696 46441 50370)		NA											8	46					0	0	0.006214	0	0
CNNM1	26507	broad.mit.edu	37	10	101090517	101090517	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:101090517G>T	uc001kpp.3	+	1	1662	c.1373G>T	c.(1372-1374)CGC>CTC	p.R458L	CNNM1_uc009xwe.2_Missense_Mutation_p.R458L|CNNM1_uc010qpi.1_Missense_Mutation_p.R458L|CNNM1_uc009xwf.2_Missense_Mutation_p.R458L	NM_020348	NP_065081	Q9NRU3	CNNM1_HUMAN	cyclin M1	458	CBS 1.				ion transport	integral to membrane|plasma membrane					0		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		GAGATCCTGCGCAGCGGCTAC	0.597			NA											9	28					4.68919e-08	6.2631e-08	0.008291	1	0
PSD	5662	broad.mit.edu	37	10	104170620	104170620	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:104170620G>T	uc001kvg.1	-	10	2613	c.2086C>A	c.(2086-2088)CTC>ATC	p.L696I	PSD_uc001kvf.1_5'Flank|PSD_uc001kvh.1_Missense_Mutation_p.L317I|PSD_uc009xxd.1_Missense_Mutation_p.L696I	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	696	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		CCCACCTTGAGCAGCTCCCTA	0.657			NA											13	71					6.72482e-11	9.92927e-11	0.003163	1	0
CALHM2	51063	broad.mit.edu	37	10	105209507	105209507	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:105209507G>A	uc001kwz.2	-	2	578	c.192C>T	c.(190-192)CCC>CCT	p.P64P	CALHM2_uc001kxa.2_Silent_p.P64P|CALHM2_uc001kxc.2_Silent_p.P64P|CALHM2_uc001kxb.2_Silent_p.P64P|CALHM2_uc001kxd.1_Silent_p.P64P	NM_015916	NP_057000	Q9HA72	CAHM2_HUMAN	calcium homeostasis modulator 2	64	Helical; (Potential).					integral to membrane				skin(1)	1						GCACCAGGGCGGGCACGCCGA	0.667			NA											14	50					0	0	0.004007	0	0
SORCS3	22986	broad.mit.edu	37	10	106960943	106960943	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:106960943C>T	uc001kyi.1	+	16	2420	c.2193C>T	c.(2191-2193)GCC>GCT	p.A731A	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	731	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CTCAGTGTGCCCTGGGCCGAG	0.478	NSCLC(116;1497 1690 7108 13108 14106)		NA											20	64					0	0	0.007413	0	0
SORCS3	22986	broad.mit.edu	37	10	106974285	106974285	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:106974285C>T	uc001kyi.1	+	18	2688	c.2461C>T	c.(2461-2463)CCT>TCT	p.P821S	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	821	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TGGAAAAGCCCCTCGGGGCCT	0.567	NSCLC(116;1497 1690 7108 13108 14106)		NA											12	45					0	0	0.001368	0	0
SORCS1	114815	broad.mit.edu	37	10	108447971	108447971	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:108447971C>T	uc001kym.2	-	10	1547	c.1539G>A	c.(1537-1539)GGG>GGA	p.G513G	SORCS1_uc001kyl.2_Silent_p.G513G|SORCS1_uc009xxs.2_Silent_p.G513G|SORCS1_uc001kyn.1_Silent_p.G513G|SORCS1_uc001kyo.2_Silent_p.G513G	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	513	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GCACGGGGTCCCCCCTTAGAT	0.488			NA											17	74					0	0	0.007413	0	0
KCNK18	338567	broad.mit.edu	37	10	118969189	118969189	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:118969189C>T	uc010qsr.1	+	3	534	c.534C>T	c.(532-534)TCC>TCT	p.S178S		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	178	Cytoplasmic (Potential).					integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		CCCTCCTCTCCAAGTGGTGCC	0.517			NA											25	93					0	0	0.00333	0	0
GRK5	2869	broad.mit.edu	37	10	121086101	121086101	+	Nonsense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:121086101T>A	uc001led.2	+	2	359	c.126T>A	c.(124-126)TGT>TGA	p.C42*	GRK5_uc009xzh.2_5'UTR|GRK5_uc010qta.1_5'UTR	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	42	N-terminal.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		TTAGCCAGTGTGAAGACCTCC	0.537			NA											11	46					0	0	0.008291	0	0
SEC23IP	11196	broad.mit.edu	37	10	121671606	121671606	+	Silent	SNP	G	G	T	rs146017364		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:121671606G>T	uc001leu.1	+	6	1314	c.1242G>T	c.(1240-1242)ACG>ACT	p.T414T	SEC23IP_uc010qtc.1_Silent_p.T203T	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	414					Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		GGGGCACCACGCAAGATGGAC	0.438			NA											22	82					2.98393e-07	3.86806e-07	0.00278	1	0
C10orf88	80007	broad.mit.edu	37	10	124697465	124697465	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:124697465T>A	uc001lgw.2	-	5	1084	c.859A>T	c.(859-861)AAT>TAT	p.N287Y	C10orf88_uc001lgx.2_Missense_Mutation_p.N189Y	NM_024942	NP_079218	Q9H8K7	CJ088_HUMAN	hypothetical protein LOC80007	287											0		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0735)		TTGGTAGAATTCTCTCCACCA	0.373			NA											18	42					0	0	0.007413	0	0
ADAM12	8038	broad.mit.edu	37	10	127782644	127782644	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:127782644T>C	uc001ljk.2	-	11	1477	c.1064A>G	c.(1063-1065)AAT>AGT	p.N355S	ADAM12_uc010qul.1_Missense_Mutation_p.N306S|ADAM12_uc001ljm.2_Missense_Mutation_p.N355S|ADAM12_uc001ljn.2_Missense_Mutation_p.N352S|ADAM12_uc001ljl.3_Missense_Mutation_p.N352S	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	355	Extracellular (Potential).|Peptidase M12B.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		CATCCCGAAATTGTGGCCCAG	0.502			NA											16	54					0	0	0.004007	0	0
INPP5A	3632	broad.mit.edu	37	10	134463936	134463936	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:134463936G>T	uc001llp.2	+	4	481	c.233G>T	c.(232-234)AGT>ATT	p.S78I	INPP5A_uc001llo.1_Missense_Mutation_p.S78I|INPP5A_uc001llq.2_Missense_Mutation_p.S30I	NM_005539	NP_005530	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase A	78					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			skin(1)	1		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		CTATTGTCGAGTGATGCGATG	0.507	Pancreas(63;823 1267 11107 20380 51626)		NA											56	204					7.22619e-39	1.3688e-38	0.00361	1	0
INPP5A	3632	broad.mit.edu	37	10	134595383	134595383	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr10:134595383C>T	uc001llp.2	+	15	1425	c.1177C>T	c.(1177-1179)CGA>TGA	p.R393*	INPP5A_uc001llq.2_Nonsense_Mutation_p.R288*	NM_005539	NP_005530	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase A	393					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			skin(1)	1		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		CCTGGCCTTCCGAATCATGCC	0.612	Pancreas(63;823 1267 11107 20380 51626)		NA											10	60					0	0	0.006214	0	0
TALDO1	6888	broad.mit.edu	37	11	764307	764307	+	Silent	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:764307A>G	uc001lqz.2	+	7	905	c.855A>G	c.(853-855)GAA>GAG	p.E285E	TALDO1_uc001lra.2_Missense_Mutation_p.K284R	NM_006755	NP_006746	P37837	TALDO_HUMAN	transaldolase 1	285					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;4.66e-26)|Epithelial(43;2.97e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.48e-19)|BRCA - Breast invasive adenocarcinoma(625;4.41e-05)|Lung(200;0.0595)|LUSC - Lung squamous cell carcinoma(625;0.0712)		GTGACCTGGAAAAAATCCACC	0.582			NA											4	82					0	0	0.009096	0	0
MUC2	4583	broad.mit.edu	37	11	1088725	1088725	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:1088725C>G	uc001lsx.1	+	26	3537	c.3510C>G	c.(3508-3510)GAC>GAG	p.D1170E		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	1170						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GCCCCAAGGACAGGCCCATCT	0.622			NA											5	14					0	0	0.001168	0	0
LSP1	4046	broad.mit.edu	37	11	1904748	1904748	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:1904748G>C	uc001lui.2	+	4	631	c.456G>C	c.(454-456)CAG>CAC	p.Q152H	LSP1_uc001luj.2_Missense_Mutation_p.Q280H|LSP1_uc001luk.2_Missense_Mutation_p.Q90H|LSP1_uc001lul.2_Missense_Mutation_p.Q90H|LSP1_uc001lum.2_Missense_Mutation_p.Q90H	NM_002339	NP_002330	P33241	LSP1_HUMAN	lymphocyte-specific protein 1 isoform 1	152					cellular component movement|cellular defense response	actin cytoskeleton|Golgi apparatus|plasma membrane	actin binding|signal transducer activity			large_intestine(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|Lung(200;0.0729)|LUSC - Lung squamous cell carcinoma(625;0.0856)		ACACTGTCCAGGACAACCTGG	0.637			NA											7	27					0	0	0.001984	0	0
TRPM5	29850	broad.mit.edu	37	11	2432703	2432703	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:2432703G>A	uc001lwm.3	-	18	2670	c.2661C>T	c.(2659-2661)TAC>TAT	p.Y887Y	TRPM5_uc010qxl.1_Silent_p.Y887Y|TRPM5_uc009ydn.2_Silent_p.Y889Y	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	887	Helical; (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		TGGTGACACCGTAGGCCACGA	0.652	NSCLC(1;49 61 17205 18850 43201)		NA											17	35					0	0	0.006122	0	0
OR51S1	119692	broad.mit.edu	37	11	4869754	4869754	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:4869754C>T	uc010qyo.1	-	1	685	c.685G>A	c.(685-687)GGC>AGC	p.G229S		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		AACACCTTGCCAATCAGGCCA	0.542			NA											12	35					0	0	0.001368	0	0
OR52N2	390077	broad.mit.edu	37	11	5842333	5842333	+	Silent	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:5842333T>A	uc010qzp.1	+	1	768	c.768T>A	c.(766-768)GCT>GCA	p.A256A	TRIM5_uc001mbq.1_Intron	NM_001005174	NP_001005174	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N,	256	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTATGTTGCTGCTTTTTTCA	0.448			NA											10	105					0	0	0.008291	0	0
FAM160A2	84067	broad.mit.edu	37	11	6232933	6232933	+	Missense_Mutation	SNP	G	G	A	rs139429864		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:6232933G>A	uc001mcl.3	-	12	3081	c.2722C>T	c.(2722-2724)CGG>TGG	p.R908W	FAM160A2_uc001mck.3_Missense_Mutation_p.R922W	NM_001098794	NP_001092264	Q8N612	F16A2_HUMAN	hypothetical protein LOC84067 isoform 2	908					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			skin(2)	2						GCCCCGCCCCGGGTGAGTAGA	0.597			NA											15	85					0	0	0.003163	0	0
SYT9	143425	broad.mit.edu	37	11	7441797	7441797	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:7441797C>A	uc001mfe.2	+	6	1635	c.1398C>A	c.(1396-1398)GGC>GGA	p.G466G	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_RNA	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	466	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		AGAGGCTGGGCAGAGACCACT	0.483			NA											31	42					9.93527e-08	1.31446e-07	0.002836	1	0
SLC6A5	9152	broad.mit.edu	37	11	20636271	20636271	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:20636271G>T	uc001mqd.2	+	6	1305	c.1032G>T	c.(1030-1032)TCG>TCT	p.S344S	SLC6A5_uc009yic.2_Silent_p.S109S	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	344	Extracellular (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	TCAAGAACTCGACTTTCTGCA	0.408			NA											34	82					1.62565e-12	2.48609e-12	0.002445	1	0
NELL1	4745	broad.mit.edu	37	11	21250989	21250989	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:21250989C>A	uc001mqe.2	+	14	1691	c.1538C>A	c.(1537-1539)ACC>AAC	p.T513N	NELL1_uc001mqf.2_Missense_Mutation_p.T513N|NELL1_uc009yid.2_Missense_Mutation_p.T541N|NELL1_uc010rdo.1_Missense_Mutation_p.T456N|NELL1_uc010rdp.1_Missense_Mutation_p.T273N	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	513	EGF-like 3.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GGGAACGGGACCATCTGCAGA	0.577			NA											11	11					3.07112e-06	3.80187e-06	0.000978	1	0
NELL1	4745	broad.mit.edu	37	11	21581833	21581833	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:21581833T>C	uc001mqe.2	+	17	2038	c.1885T>C	c.(1885-1887)TCC>CCC	p.S629P	NELL1_uc001mqf.2_Missense_Mutation_p.S582P|NELL1_uc009yid.2_Missense_Mutation_p.S657P|NELL1_uc010rdo.1_Missense_Mutation_p.S572P|NELL1_uc010rdp.1_Missense_Mutation_p.S342P|NELL1_uc001mqh.2_Intron	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	629	EGF-like 6; calcium-binding (Potential).				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						CTCTGGGCCCTCCTGCTCTGG	0.547			NA											23	52					0	0	0.002299	0	0
MPPED2	744	broad.mit.edu	37	11	30516971	30516971	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:30516971G>A	uc001msr.2	-	3	528	c.408C>T	c.(406-408)TAC>TAT	p.Y136Y	MPPED2_uc001msq.3_Silent_p.Y136Y|MPPED2_uc009yji.2_Silent_p.Y10Y	NM_001584	NP_001575	Q15777	MPPD2_HUMAN	metallophosphoesterase domain containing 2	136					nervous system development		hydrolase activity|metal ion binding			skin(1)	1						AGGGGAAACGGTAGTAGTCCT	0.403			NA											5	58					0	0	0.000602	0	0
RAG1	5896	broad.mit.edu	37	11	36596039	36596039	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:36596039C>A	uc001mwu.3	+	2	1309	c.1185C>A	c.(1183-1185)CCC>CCA	p.P395P	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	395	NBD.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				GGGGCCGGCCCCGCCAACATC	0.483	Pancreas(43;321 1249 3212 48200)|Esophageal Squamous(38;49 1003 17530 24363)		NA							Familial_Hemophagocytic_Lymphohistiocytosis				26	53					1.50538e-07	1.96966e-07	0.00632	1	0
LRRC4C	57689	broad.mit.edu	37	11	40137206	40137206	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:40137206G>T	uc001mxa.1	-	2	2601	c.637C>A	c.(637-639)CCT>ACT	p.P213T	LRRC4C_uc001mxc.1_Missense_Mutation_p.P209T|LRRC4C_uc001mxd.1_Missense_Mutation_p.P209T|LRRC4C_uc001mxb.1_Missense_Mutation_p.P209T	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	213	LRR 6.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GTGAGGTTAGGGATTTCCCGA	0.458			NA											23	47					1.55469e-16	2.58277e-16	0.00333	1	0
PHF21A	51317	broad.mit.edu	37	11	46105753	46105753	+	Silent	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:46105753T>A	uc001ncc.3	-	3	642	c.18A>T	c.(16-18)CTA>CTT	p.L6L	PHF21A_uc001ncb.3_Silent_p.L6L|PHF21A_uc009ykx.2_Silent_p.L6L|PHF21A_uc001nce.2_Silent_p.L6L	NM_001101802	NP_001095272	Q96BD5	PF21A_HUMAN	BRAF35/HDAC2 complex isoform a	6	Gln-rich.				blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						GAGCCTCCTGTAGAGTCTGCA	0.403			NA											12	28					0	0	0.000978	0	0
MYBPC3	4607	broad.mit.edu	37	11	47360129	47360129	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:47360129C>A	uc001nfa.3	-	22	2305	c.2250G>T	c.(2248-2250)ACG>ACT	p.T750T	MYBPC3_uc010rhl.1_RNA	NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	749	Ig-like C2-type 5.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		TCACTGTGACCGTGTAGACGC	0.632			NA											16	27					3.52763e-06	4.3565e-06	0.00499	1	0
FOLH1	2346	broad.mit.edu	37	11	49186290	49186290	+	Silent	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:49186290C>G	uc001ngy.2	-	13	1668	c.1407G>C	c.(1405-1407)CTG>CTC	p.L469L	FOLH1_uc001ngz.2_Silent_p.L469L|FOLH1_uc009yly.2_Silent_p.L454L|FOLH1_uc009ylz.2_Silent_p.L454L|FOLH1_uc009yma.2_Silent_p.L161L	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	469	NAALADase.|Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	AGCTGTACATCAGCGGTGTAC	0.279			NA											14	14					0	0	0.00499	0	0
FOLH1	2346	broad.mit.edu	37	11	49229960	49229960	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:49229960A>T	uc001ngy.2	-	1	263	c.2T>A	c.(1-3)ATG>AAG	p.M1K	FOLH1_uc001ngz.2_Missense_Mutation_p.M1K|FOLH1_uc009yly.2_5'UTR|FOLH1_uc009ylz.2_5'UTR|FOLH1_uc009yma.2_5'UTR|FOLH1_uc001nha.2_5'UTR	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	1	Cytoplasmic (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	GAGATTCCACATCTCGGCGCG	0.692			NA											3	10					0	0	0.009096	0	0
OR5L1	219437	broad.mit.edu	37	11	55579417	55579417	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:55579417C>A	uc001nhw.1	+	1	475	c.475C>A	c.(475-477)CAT>AAT	p.H159N		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	159	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TTCTCTGATTCATTTGTGCTT	0.443			NA											52	171					2.27781e-18	3.87177e-18	0.00361	1	0
OR5L1	219437	broad.mit.edu	37	11	55579652	55579652	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:55579652C>A	uc001nhw.1	+	1	710	c.710C>A	c.(709-711)GCC>GAC	p.A237D		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	237	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				AGGCACAAAGCCTTCTCCACC	0.498			NA											32	115					2.47511e-08	3.35534e-08	0.008361	1	0
OR7E5P	219445	broad.mit.edu	37	11	55747441	55747441	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:55747441C>A	uc010riu.1	-	4	571	c.16G>T	c.(16-18)GTG>TTG	p.V6L		NR_027688				SubName: Full=HCG2036849; SubName: Full=Seven transmembrane helix receptor;												0						TTCCCCAGCACCGTGACCAGG	0.577			NA											14	37					2.94398e-08	3.97347e-08	0.007413	1	0
OR5F1	338674	broad.mit.edu	37	11	55761205	55761205	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:55761205C>A	uc010riv.1	-	1	897	c.897G>T	c.(895-897)AAG>AAT	p.K299N		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	299	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					TCGCTAAAGCCTTCTTTACTT	0.398			NA											20	61					8.10497e-08	1.07323e-07	0.010504	1	0
OR5F1	338674	broad.mit.edu	37	11	55761253	55761253	+	Silent	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:55761253G>C	uc010riv.1	-	1	849	c.849C>G	c.(847-849)CCC>CCG	p.P283P		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	283	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					GATTCAACATGGGAATCACCA	0.443			NA											31	85					0	0	0.009535	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798679	55798679	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:55798679C>A	uc010riw.1	+	1	785	c.785C>A	c.(784-786)CCC>CAC	p.P262H		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					TACTTACAGCCCACCACTAGC	0.418			NA											26	93					4.47668e-21	7.77236e-21	0.003954	1	0
OR8H2	390151	broad.mit.edu	37	11	55873273	55873273	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:55873273A>G	uc010riy.1	+	1	755	c.755A>G	c.(754-756)TAT>TGT	p.Y252C		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	252	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					ACCATCTTTTATAGCACTCTG	0.373			NA								HNSCC(53;0.14)			32	80					0	0	0.002445	0	0
OR8H2	390151	broad.mit.edu	37	11	55873419	55873419	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:55873419G>T	uc010riy.1	+	1	901	c.901G>T	c.(901-903)GTC>TTC	p.V301F		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					GAAAAATGCTGTCATCAGAGT	0.373			NA								HNSCC(53;0.14)			10	157					6.40141e-05	7.49101e-05	0.000978	1	0
OR8H3	390152	broad.mit.edu	37	11	55890240	55890240	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:55890240A>T	uc001nii.1	+	1	392	c.392A>T	c.(391-393)CAC>CTC	p.H131L		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					AGTCCTCTACACTACACAGTT	0.463			NA											64	190					0	0	0.00361	0	0
OR8J3	81168	broad.mit.edu	37	11	55904371	55904371	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:55904371G>T	uc010riz.1	-	1	824	c.824C>A	c.(823-825)TCT>TAT	p.S275Y		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	275	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					GTAAAACACAGAAGCCATCTT	0.398			NA											23	123					5.35356e-11	7.91977e-11	0.00278	1	0
OR8J3	81168	broad.mit.edu	37	11	55905109	55905109	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:55905109A>T	uc010riz.1	-	1	86	c.86T>A	c.(85-87)CTG>CAG	p.L29Q		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					TAGGAAGACCAGGAAGAGGGG	0.493			NA											18	181					0	0	0.00499	0	0
OR5T1	390155	broad.mit.edu	37	11	56043987	56043987	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:56043987C>A	uc001nio.1	+	1	873	c.873C>A	c.(871-873)ACC>ACA	p.T291T		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	291	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					TATTTTATACCATTGTGATTC	0.383			NA											34	128					6.70999e-13	1.03334e-12	0.004289	1	0
OR8J1	219477	broad.mit.edu	37	11	56127765	56127765	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:56127765A>T	uc010rjh.1	+	1	43	c.43A>T	c.(43-45)ACA>TCA	p.T15S		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	15	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GTTTATTCTTACAGGTGTCTC	0.463			NA											13	150					0	0	0.00499	0	0
OR8J1	219477	broad.mit.edu	37	11	56127775	56127775	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:56127775C>T	uc010rjh.1	+	1	53	c.53C>T	c.(52-54)TCT>TTT	p.S18F		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ACAGGTGTCTCTAGCTGTCCA	0.478			NA											33	142					0	0	0.005524	0	0
OR5M1	390168	broad.mit.edu	37	11	56380835	56380835	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:56380835C>A	uc001nja.1	-	1	144	c.144G>T	c.(142-144)CTG>CTT	p.L48L		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	48	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TGGTCCTGATCAGCAGGATCA	0.478			NA											25	147					1.66031e-10	2.42587e-10	0.003954	1	0
APLNR	187	broad.mit.edu	37	11	57004333	57004333	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:57004333A>T	uc001njo.2	-	1	595	c.146T>A	c.(145-147)GTG>GAG	p.V49E	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	49	Helical; Name=1; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						GGTCCAGAGCACCAGACCGTT	0.597			NA											17	56					0	0	0.008871	0	0
SLC43A3	29015	broad.mit.edu	37	11	57177518	57177518	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:57177518G>A	uc001nkg.2	-	12	1547	c.1137C>T	c.(1135-1137)TTC>TTT	p.F379F	PRG2_uc001nke.2_Intron|SLC43A3_uc001nkh.2_Silent_p.F379F|SLC43A3_uc010rjr.1_Silent_p.F392F|SLC43A3_uc009yme.2_Silent_p.F379F|SLC43A3_uc001nki.2_Silent_p.F379F	NM_014096	NP_054815	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	379					transmembrane transport	integral to membrane				central_nervous_system(1)	1						CACAGAGGGCGAAGCCCAGGC	0.617			NA											4	53					0	0	0.009096	0	0
OR9I1	219954	broad.mit.edu	37	11	57886367	57886367	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:57886367G>T	uc001nml.1	-	1	550	c.550C>A	c.(550-552)CTG>ATG	p.L184M	OR9Q1_uc001nmj.2_Intron	NM_001005211	NP_001005211	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Breast(21;0.0589)				AGCTTCAGCAGGGGTGGGAGG	0.488			NA											9	39					0.00448238	0.00488872	0.004482	1	0
OR9Q2	219957	broad.mit.edu	37	11	57958771	57958771	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:57958771G>T	uc010rka.1	+	1	809	c.809G>T	c.(808-810)GGA>GTA	p.G270V		NM_001005283	NP_001005283	Q8NGE9	OR9Q2_HUMAN	olfactory receptor, family 9, subfamily Q,	270	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)|central_nervous_system(1)	4		Breast(21;0.0589)				TCCTCCGAGGGAGACCGAGTG	0.547			NA											27	94					2.50493e-22	4.39862e-22	0.004656	1	0
OR5B17	219965	broad.mit.edu	37	11	58126446	58126446	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:58126446A>T	uc010rke.1	-	1	97	c.97T>A	c.(97-99)TAC>AAC	p.Y33N		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	33	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GTGATGAGGTAGATGAGGGTA	0.448			NA											43	146					0	0	0.00874	0	0
OR4D10	390197	broad.mit.edu	37	11	59245584	59245584	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:59245584C>G	uc001nnz.1	+	1	682	c.682C>G	c.(682-684)CAG>GAG	p.Q228E		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						ACCCAAGTCTCAGGCAGGAGA	0.507			NA											13	111					0	0	0.001855	0	0
MS4A14	84689	broad.mit.edu	37	11	60164178	60164178	+	Nonsense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:60164178A>T	uc001npj.2	+	1	692	c.127A>T	c.(127-129)AGA>TGA	p.R43*	MS4A14_uc001npi.2_Intron|MS4A14_uc001npn.2_Translation_Start_Site|MS4A14_uc001npk.2_Nonsense_Mutation_p.R43*|MS4A14_uc001npl.2_Translation_Start_Site|MS4A14_uc001npm.2_Translation_Start_Site	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	43						integral to membrane	receptor activity			breast(1)	1						GGGAGAGCCAAGAGTCTTGGG	0.428			NA											8	39					0	0	0.000978	0	0
TUT1	64852	broad.mit.edu	37	11	62356562	62356562	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:62356562G>C	uc001nto.2	-	2	366	c.328C>G	c.(328-330)CTC>GTC	p.L110V		NM_022830	NP_073741	Q9H6E5	STPAP_HUMAN	terminal uridylyl transferase 1, U6	72	RRM.				mRNA cleavage|mRNA polyadenylation|snRNA processing	nuclear speck|nucleolus	ATP binding|enzyme binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|RNA uridylyltransferase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2						TACTCAGAGAGCTGAGCAGAA	0.498			NA											4	64					0	0	0.009096	0	0
ROM1	6094	broad.mit.edu	37	11	62380969	62380969	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:62380969G>A	uc001ntv.2	+	1	757	c.216G>A	c.(214-216)GTG>GTA	p.V72V	EML3_uc001ntr.1_5'Flank|EML3_uc001nts.1_5'Flank|EML3_uc001ntt.1_5'Flank|EML3_uc001ntu.1_5'Flank|EML3_uc010rly.1_5'Flank|EML3_uc009yny.1_5'Flank	NM_000327	NP_000318	Q03395	ROM1_HUMAN	retinal outer segment membrane protein 1	72	Helical; (Potential).				cell adhesion|visual perception	integral to plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CGGGCGCGGTGGCTCTGGGCA	0.677			NA											4	24					0	0	0.000602	0	0
SLC3A2	6520	broad.mit.edu	37	11	62655812	62655812	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:62655812G>A	uc001nwd.2	+	12	1764	c.1540G>A	c.(1540-1542)GAA>AAA	p.E514K	SLC3A2_uc001nwb.2_Missense_Mutation_p.E545K|SLC3A2_uc001nwc.2_Missense_Mutation_p.E515K|SLC3A2_uc001nwe.2_Missense_Mutation_p.E483K|SLC3A2_uc001nwf.2_Missense_Mutation_p.E452K|SLC3A2_uc001nwg.2_Missense_Mutation_p.E413K	NM_002394	NP_002385	P08195	4F2_HUMAN	solute carrier family 3, member 2 isoform c	514	Extracellular (Potential).				blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding				0						GGGCCAGAGTGAAGACCCTGG	0.587			NA											15	87					0	0	0.004007	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65811101	65811101	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:65811101G>T	uc001ogv.2	-	2	333	c.173C>A	c.(172-174)CCG>CAG	p.P58Q	GAL3ST3_uc001ogw.2_Missense_Mutation_p.P58Q	NM_033036	NP_149025	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	58	Lumenal (Potential).				monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(1)	1						GGGGCGCGGCGGCGAGTTCCG	0.647			NA											10	24					5.50884e-06	6.74373e-06	0.001368	1	0
CD248	57124	broad.mit.edu	37	11	66084211	66084211	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:66084211C>A	uc001ohm.1	-	1	305	c.288G>T	c.(286-288)CTG>CTT	p.L96L		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	96	C-type lectin.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	GTGGGCGCTGCAGCTGGCATT	0.736			NA											10	35					1.76689e-08	2.4016e-08	0.006214	1	0
RIN1	9610	broad.mit.edu	37	11	66101539	66101539	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:66101539C>A	uc001ohn.1	-	7	1569	c.1442G>T	c.(1441-1443)GGG>GTG	p.G481V	RIN1_uc010roy.1_Intron|RIN1_uc009yrd.1_Missense_Mutation_p.G174V|RIN1_uc010roz.1_Missense_Mutation_p.G376V|RIN1_uc010rpa.1_Intron	NM_004292	NP_004283	Q13671	RIN1_HUMAN	ras inhibitor RIN1	481	VPS9.|Ras and 14-3-3 protein binding region.				endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			lung(2)|breast(1)	3						CAGGTGGGACCCGAAGGCTCC	0.736			NA											5	8					8.12818e-05	9.43997e-05	0.001984	1	0
CTSF	8722	broad.mit.edu	37	11	66335115	66335115	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:66335115G>C	uc001oip.2	-	3	421	c.331C>G	c.(331-333)CTG>GTG	p.L111V		NM_003793	NP_003784	Q9UBX1	CATF_HUMAN	cathepsin F precursor	111					proteolysis	lysosome	cysteine-type endopeptidase activity				0						AGCTCATCCAGGACTTGGAAG	0.612			NA											13	103					0	0	0.00245	0	0
SSH3	54961	broad.mit.edu	37	11	67077689	67077689	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:67077689C>T	uc001okj.2	+	13	1740	c.1562C>T	c.(1561-1563)GCC>GTC	p.A521V	SSH3_uc001okk.2_RNA|SSH3_uc001okl.2_Missense_Mutation_p.A375V	NM_017857	NP_060327	Q8TE77	SSH3_HUMAN	slingshot homolog 3	521					regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			AGCCAGGCAGCCCCGAAAGAA	0.602			NA											27	111					0	0	0.005443	0	0
PDE2A	5138	broad.mit.edu	37	11	72290403	72290403	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:72290403T>A	uc010rrc.1	-	27	2524	c.2281A>T	c.(2281-2283)ATG>TTG	p.M761L	PDE2A_uc001oso.2_Missense_Mutation_p.M740L|PDE2A_uc010rra.1_Missense_Mutation_p.M754L|PDE2A_uc001osn.2_Missense_Mutation_p.M505L|PDE2A_uc010rrb.1_Missense_Mutation_p.M752L|PDE2A_uc010rrd.1_Missense_Mutation_p.M646L	NM_002599	NP_002590	O00408	PDE2A_HUMAN	phosphodiesterase 2A isoform 1	761	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	ATGTCCCGCATCAGATCCAGC	0.597			NA											14	37					0	0	0.00245	0	0
C11orf82	220042	broad.mit.edu	37	11	82643033	82643033	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:82643033A>G	uc001ozt.2	+	6	897	c.653A>G	c.(652-654)TAT>TGT	p.Y218C	C11orf82_uc010rsr.1_Translation_Start_Site|C11orf82_uc010rss.1_Translation_Start_Site|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	218					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						AGCAGCATATATACTTCTGAC	0.378			NA											27	108					0	0	0.004656	0	0
DLG2	1740	broad.mit.edu	37	11	83641482	83641482	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:83641482T>A	uc001paj.2	-	10	1373	c.1070A>T	c.(1069-1071)AAG>ATG	p.K357M	DLG2_uc001pai.2_Intron|DLG2_uc010rsy.1_Missense_Mutation_p.K324M|DLG2_uc010rsz.1_Missense_Mutation_p.K357M|DLG2_uc010rta.1_Missense_Mutation_p.K357M|DLG2_uc001pak.2_Missense_Mutation_p.K462M|DLG2_uc010rtb.1_Missense_Mutation_p.K324M|DLG2_uc001pal.1_Missense_Mutation_p.K357M|DLG2_uc001pam.1_Missense_Mutation_p.K396M	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	357						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				AGAAGCAGGCTTATCACATAG	0.488			NA											21	130					0	0	0.005443	0	0
DLG2	1740	broad.mit.edu	37	11	84245776	84245776	+	Splice_Site	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:84245776T>C	uc001paj.2	-	2	346	c.43_splice	c.e2-1	p.K15_splice	DLG2_uc010rsz.1_Splice_Site_p.K15_splice|DLG2_uc010rta.1_Splice_Site_p.K15_splice|DLG2_uc001pak.2_Splice_Site_p.K120_splice|DLG2_uc001pal.1_Splice_Site_p.K15_splice	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2							cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TCGATACTTCTAGGAGAAAAG	0.393			NA											16	205					0	0	0.006122	0	0
EED	8726	broad.mit.edu	37	11	85963272	85963272	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:85963272G>T	uc001pbp.2	+	3	807	c.350G>T	c.(349-351)GGA>GTA	p.G117V	EED_uc010rtm.1_Missense_Mutation_p.G117V|EED_uc001pbq.2_Missense_Mutation_p.G117V|EED_uc001pbr.2_Missense_Mutation_p.G117V|EED_uc001pbs.2_Missense_Mutation_p.G117V	NM_003797	NP_003788	O75530	EED_HUMAN	embryonic ectoderm development isoform a	117	Interaction with EZH2 (By similarity).|WD 1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			skin(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				GCAACTGTAGGAAGCAACAGA	0.338			NA											5	65					0.000602214	0.000674971	0.000602	1	0
EED	8726	broad.mit.edu	37	11	85979601	85979601	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:85979601A>G	uc001pbp.2	+	9	1421	c.964A>G	c.(964-966)AAG>GAG	p.K322E	EED_uc010rtm.1_Missense_Mutation_p.K322E|EED_uc001pbq.2_Missense_Mutation_p.K322E|EED_uc001pbr.2_Missense_Mutation_p.K322E|EED_uc001pbs.2_Intron|EED_uc010rtn.1_Intron	NM_003797	NP_003788	O75530	EED_HUMAN	embryonic ectoderm development isoform a	322	Interaction with EZH2 (By similarity).|Required for interaction with the matrix protein MA of HIV-1.|WD 5.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			skin(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				GATACTTTCTAAGGTATGGTA	0.308			NA											20	94					0	0	0.001882	0	0
PRSS23	11098	broad.mit.edu	37	11	86519409	86519409	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:86519409G>T	uc001pcb.2	+	2	940	c.724G>T	c.(724-726)GGC>TGC	p.G242C	PRSS23_uc001pcc.1_Intron|PRSS23_uc010rts.1_Missense_Mutation_p.G210C	NM_007173	NP_009104	O95084	PRS23_HUMAN	protease, serine, 23 precursor	242					proteolysis	extracellular region|nucleus	serine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CAATGACATCGGCATGGATTA	0.522			NA											12	51					1.5842e-08	2.18022e-08	0.001855	1	0
TYR	7299	broad.mit.edu	37	11	89018021	89018021	+	Missense_Mutation	SNP	G	G	T	rs61754393		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:89018021G>T	uc001pcs.2	+	4	1347	c.1265G>T	c.(1264-1266)CGG>CTG	p.R422L		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	422	Lumenal, melanosome (Potential).		R -> Q (in OCA1A and OCA1B; temperature sensitive variant).		eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	GGACATAACCGGGAATCCTAC	0.413			NA							Oculocutaneous_Albinism				28	95					8.58068e-18	1.45212e-17	0.007291	1	0
FOLH1B	219595	broad.mit.edu	37	11	89420530	89420530	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:89420530G>A	uc001pda.2	+	9	1058	c.532G>A	c.(532-534)GAA>AAA	p.E178K		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	178					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						AAGCCCTGATGAAGGCTTTGA	0.343			NA											5	90					0	0	0.000602	0	0
Unknown	0	broad.mit.edu	37	11	89774530	89774530	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:89774530C>G	uc010rua.1	+	7	1294	c.1171C>G	c.(1171-1173)CTC>GTC	p.L391V		NM_020358	NP_065091			ring finger protein 18												NA						TCAATGCAGTCTCTTTACCAC	0.418			NA											9	111					0	0	0.000978	0	0
FAT3	120114	broad.mit.edu	37	11	92534273	92534273	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:92534273C>A	uc001pdj.3	+	9	8111	c.8094C>A	c.(8092-8094)GTC>GTA	p.V2698V		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2698	Cadherin 24.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATATCCACGTCTTGCCCCCTG	0.463			NA								TCGA Ovarian(4;0.039)			17	55					1.99824e-07	2.59686e-07	0.00499	1	0
GPR83	10888	broad.mit.edu	37	11	94134282	94134282	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:94134282C>A	uc001pet.2	-	1	304	c.132G>T	c.(130-132)TGG>TGT	p.W44C		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	44	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TGTAGTTGTTCCAAGAGAAGA	0.652			NA											11	59					0.000978159	0.00108999	0.000978	1	0
KDM4D	55693	broad.mit.edu	37	11	94731487	94731487	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:94731487G>T	uc001pfe.2	+	3	1783	c.951G>T	c.(949-951)GTG>GTT	p.V317V		NM_018039	NP_060509	Q6B0I6	KDM4D_HUMAN	jumonji domain containing 2D	317					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						AGGCAAGGGTGACCTTTTCCA	0.552			NA											17	79					3.45872e-05	4.11307e-05	0.004007	1	0
KDM4DL	390245	broad.mit.edu	37	11	94759373	94759373	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:94759373C>G	uc010ruf.1	+	1	952	c.652C>G	c.(652-654)CAG>GAG	p.Q218E		NM_001161630	NP_001155102	B2RXH2	KD4DL_HUMAN	lysine (K)-specific demethylase 4D-like	218	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						AGAACATGGTCAGCACCTGGA	0.577			NA											19	63					0	0	0.007413	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103039571	103039571	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:103039571A>T	uc001pho.2	+	32	4994	c.4850A>T	c.(4849-4851)CAG>CTG	p.Q1617L	DYNC2H1_uc001phn.1_Missense_Mutation_p.Q1617L|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	1617	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AACCAAATTCAGGTTCATACA	0.353			NA											7	72					0	0	0.001984	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103182692	103182692	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:103182692G>C	uc001pho.2	+	79	11723	c.11579G>C	c.(11578-11580)CGA>CCA	p.R3860P	DYNC2H1_uc001phn.1_Missense_Mutation_p.R3867P|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3860	AAA 6 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity	p.R1300Q(3)			0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AATACACATCGAGCTCATGCT	0.358			NA											22	118					0	0	0.001882	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103182715	103182715	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:103182715G>T	uc001pho.2	+	79	11746	c.11602G>T	c.(11602-11604)GCA>TCA	p.A3868S	DYNC2H1_uc001phn.1_Missense_Mutation_p.A3875S|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3868	AAA 6 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CTTCAGTCTTGCATGGTTTCA	0.338			NA											29	134					2.85442e-18	4.84653e-18	0.002096	1	0
DYNC2H1	79659	broad.mit.edu	37	11	103270477	103270477	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:103270477T>G	uc001pho.2	+	84	12387	c.12243T>G	c.(12241-12243)TTT>TTG	p.F4081L	DYNC2H1_uc001phn.1_Missense_Mutation_p.F4088L|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	4081					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TTGAACAATTTAATGCTATTC	0.373			NA											20	59					0	0	0.001882	0	0
PDGFD	80310	broad.mit.edu	37	11	103780531	103780531	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:103780531G>T	uc001phq.2	-	7	1376	c.1004C>A	c.(1003-1005)CCT>CAT	p.P335H	PDGFD_uc001php.2_Missense_Mutation_p.P329H	NM_025208	NP_079484	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D isoform 1	335					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		GATGTGGCCAGGCTCAAACTG	0.453			NA											41	137					1.76056e-25	3.17106e-25	0.002852	1	0
CWF19L2	143884	broad.mit.edu	37	11	107224348	107224348	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:107224348C>A	uc010rvp.1	-	13	2017	c.1987G>T	c.(1987-1989)GCT>TCT	p.A663S	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_RNA	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	663	Potential.						catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		CGATGCTCAGCAATAGCTTTT	0.418			NA											39	73					1.30998e-17	2.20961e-17	0.005524	1	0
CWF19L2	143884	broad.mit.edu	37	11	107299594	107299594	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:107299594T>A	uc010rvp.1	-	8	1394	c.1364A>T	c.(1363-1365)CAA>CTA	p.Q455L	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_RNA	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	455							catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		GACTTCATCTTGTGATTTTTC	0.373			NA											34	329					0	0	0.002445	0	0
BCO2	83875	broad.mit.edu	37	11	112084521	112084521	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:112084521G>T	uc001pnf.2	+	9	1386	c.1269G>T	c.(1267-1269)GAG>GAT	p.E423D	BCO2_uc001pne.1_Missense_Mutation_p.E250D|BCO2_uc001png.2_Missense_Mutation_p.E350D|BCO2_uc001pnh.2_Missense_Mutation_p.E389D|BCO2_uc010rwt.1_Missense_Mutation_p.E318D|BCO2_uc009yyn.2_Missense_Mutation_p.E389D|BCO2_uc001pni.2_Missense_Mutation_p.E389D	NM_031938	NP_114144	Q9BYV7	BCDO2_HUMAN	beta-carotene dioxygenase 2 isoform a	423					carotene metabolic process|retinal metabolic process|retinoic acid metabolic process		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						ATGCCCCTGAGGGAGACAACC	0.433	GBM(177;1916 2099 21049 29541 39946)		NA											60	144					2.69953e-25	4.85664e-25	0.00361	1	0
TTC12	54970	broad.mit.edu	37	11	113195353	113195353	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:113195353G>T	uc001pnu.2	+	5	376	c.271G>T	c.(271-273)GAT>TAT	p.D91Y	TTC12_uc001pnv.2_Missense_Mutation_p.D91Y|TTC12_uc001pnw.2_RNA|TTC12_uc001pnx.2_5'UTR	NM_017868	NP_060338	Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	91							binding			pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		TGTGGAGAAGGATGCAAAGGA	0.398			NA											8	43					1.06961e-07	1.40907e-07	0.00308	1	0
ZW10	9183	broad.mit.edu	37	11	113608401	113608401	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:113608401C>A	uc001poe.2	-	14	1946	c.1909G>T	c.(1909-1911)GGA>TGA	p.G637*	ZW10_uc009yyv.2_RNA	NM_004724	NP_004715	O43264	ZW10_HUMAN	centromere/kinetochore protein zw10	637					cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		CACACAATTCCAAGTCTCTTT	0.383			NA											29	119					1.16021e-09	1.64827e-09	0.007291	1	0
HTR3B	9177	broad.mit.edu	37	11	113803681	113803681	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:113803681C>T	uc001pok.2	+	6	629	c.562C>T	c.(562-564)CTG>TTG	p.L188L	HTR3B_uc001pol.2_Silent_p.L177L	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	188	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		CCTGGCCTTTCTGAGGAGCCC	0.468			NA											21	76					0	0	0.00278	0	0
APOC3	345	broad.mit.edu	37	11	116701533	116701533	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:116701533G>T	uc001ppt.1	+	3	146	c.100G>T	c.(100-102)GGT>TGT	p.G34C		NM_000040	NP_000031	P02656	APOC3_HUMAN	apolipoprotein C-III precursor	34					Cdc42 protein signal transduction|cholesterol efflux|cholesterol homeostasis|chylomicron remnant clearance|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle remodeling|lipoprotein metabolic process|negative regulation of cholesterol import|negative regulation of fatty acid biosynthetic process|negative regulation of high-density lipoprotein particle clearance|negative regulation of lipoprotein lipase activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor-mediated endocytosis|negative regulation of triglyceride catabolic process|negative regulation of very-low-density lipoprotein particle clearance|negative regulation of very-low-density lipoprotein particle remodeling|phospholipid efflux|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle assembly	chylomicron|intermediate-density lipoprotein particle|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	high-density lipoprotein particle receptor binding|lipase inhibitor activity|phospholipid binding				0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		CTTCATGCAGGGTTACATGAA	0.642	GBM(81;259 1650 7161 35190)		NA											9	43					1.76689e-08	2.4016e-08	0.006214	1	0
SIDT2	51092	broad.mit.edu	37	11	117058097	117058097	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:117058097A>T	uc001pqh.1	+	11	1060	c.1019A>T	c.(1018-1020)CAC>CTC	p.H340L	SIDT2_uc010rxe.1_Missense_Mutation_p.H340L|SIDT2_uc001pqg.2_Missense_Mutation_p.H340L|SIDT2_uc001pqi.1_Missense_Mutation_p.H344L	NM_001040455	NP_001035545	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2 precursor	340	Cytoplasmic (Potential).					integral to membrane|lysosomal membrane					0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		ATTGCAGGTCACCCTCGAGTC	0.527			NA											7	142					0	0	0.006214	0	0
TRIM29	23650	broad.mit.edu	37	11	119998125	119998125	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:119998125A>C	uc001pwz.2	-	3	1177	c.1053T>G	c.(1051-1053)GAT>GAG	p.D351E	TRIM29_uc010rzi.1_Missense_Mutation_p.D90E|TRIM29_uc010rzj.1_Missense_Mutation_p.D84E|TRIM29_uc001pxa.2_RNA	NM_012101	NP_036233	Q14134	TRI29_HUMAN	tripartite motif protein TRIM29	351	Potential.				transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		TGGCTCTCTCATCCAGAGCAT	0.572			NA											11	146					0	0	0.001368	0	0
SORL1	6653	broad.mit.edu	37	11	121495847	121495847	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:121495847G>T	uc001pxx.2	+	46	6305	c.6225G>T	c.(6223-6225)GGG>GGT	p.G2075G	SORL1_uc010rzp.1_Silent_p.G921G|SORL1_uc010rzq.1_Silent_p.G690G	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	2075	Extracellular (Potential).|Fibronectin type-III 6.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CTTACCTTGGGAATACTACTG	0.398			NA											40	122					2.95478e-19	5.05595e-19	0.00874	1	0
OR10G8	219869	broad.mit.edu	37	11	123900553	123900553	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:123900553C>T	uc001pzp.1	+	1	224	c.224C>T	c.(223-225)ACG>ATG	p.T75M		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	75	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TCCACTGTCACGGTGCCCAAA	0.522			NA											33	150					0	0	0.003271	0	0
OR10G8	219869	broad.mit.edu	37	11	123901089	123901089	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:123901089G>C	uc001pzp.1	+	1	760	c.760G>C	c.(760-762)GGT>CGT	p.G254R		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	254	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CTTTGGCCCTGGTCTTTTCAT	0.552			NA											34	117					0	0	0.003271	0	0
OR8B3	390271	broad.mit.edu	37	11	124266395	124266395	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:124266395T>A	uc010saj.1	-	1	853	c.853A>T	c.(853-855)AAT>TAT	p.N285Y	OR8B2_uc001qab.3_Intron	NM_001005467	NP_001005467	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B,	285	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		ATGAGAGGATTGAGCATGGGC	0.373			NA											35	132					0	0	0.003755	0	0
OR8B8	26493	broad.mit.edu	37	11	124310761	124310761	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:124310761G>T	uc010sal.1	-	1	221	c.221C>A	c.(220-222)TCC>TAC	p.S74Y		NM_012378	NP_036510	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B,	74	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		GATAACACTGGAATAGCAGAA	0.428			NA											25	67					4.87955e-14	7.71511e-14	0.005443	1	0
ROBO3	64221	broad.mit.edu	37	11	124742353	124742353	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:124742353C>A	uc001qbc.2	+	8	1427	c.1235C>A	c.(1234-1236)ACC>AAC	p.T412N		NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	412	Ig-like C2-type 4.|Extracellular (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CTTAACATCACCGCGGTGCAG	0.602			NA											9	50					1.12685e-05	1.36427e-05	0.004482	1	0
CCDC15	80071	broad.mit.edu	37	11	124857934	124857934	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:124857934G>T	uc001qbm.3	+	8	2071	c.1812G>T	c.(1810-1812)CAG>CAT	p.Q604H		NM_025004	NP_079280	Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	604						centrosome				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		CCATATGTCAGGACCGGGATT	0.413			NA											32	164					1.13719e-10	1.67106e-10	0.008361	1	0
CDON	50937	broad.mit.edu	37	11	125864222	125864222	+	Silent	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:125864222T>A	uc009zbw.2	-	14	2735	c.2607A>T	c.(2605-2607)ACA>ACT	p.T869T	CDON_uc001qdb.3_Silent_p.T246T|CDON_uc001qdc.3_Silent_p.T869T	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	869	Extracellular (Potential).|Fibronectin type-III 3.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		TGTCACTATCTGTTGGTCGGT	0.388			NA											5	38					0	0	0.001984	0	0
RPUSD4	84881	broad.mit.edu	37	11	126081500	126081500	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:126081500A>T	uc001qde.2	-	1	88	c.34T>A	c.(34-36)TGG>AGG	p.W12R	FAM118B_uc001qdf.2_5'Flank|FAM118B_uc009zca.2_5'Flank|FAM118B_uc001qdg.2_5'Flank|RPUSD4_uc009zbz.2_Missense_Mutation_p.W12R|RPUSD4_uc009zby.2_RNA	NM_032795	NP_116184	Q96CM3	RUSD4_HUMAN	RNA pseudouridylate synthase domain containing 4	12					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			breast(1)	1	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0761)		CCCCGGATCCAGGGGCCCGAC	0.637			NA											52	115					0	0	0.00361	0	0
FAM118B	79607	broad.mit.edu	37	11	126110847	126110847	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:126110847G>A	uc001qdf.2	+	4	430	c.247G>A	c.(247-249)GAA>AAA	p.E83K	FAM118B_uc009zca.2_Missense_Mutation_p.E87K|FAM118B_uc001qdg.2_Missense_Mutation_p.E83K	NM_024556	NP_078832	Q9BPY3	F118B_HUMAN	hypothetical protein LOC79607	83											0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0784)		TGATCTTTTAGAAGATGAGGA	0.463			NA											26	229					0	0	0.003954	0	0
NTM	50863	broad.mit.edu	37	11	132016316	132016316	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:132016316A>G	uc001qgp.2	+	2	972	c.308A>G	c.(307-309)CAG>CGG	p.Q103R	NTM_uc001qgm.2_Missense_Mutation_p.Q103R|NTM_uc010sch.1_Missense_Mutation_p.Q94R|NTM_uc010sci.1_Missense_Mutation_p.Q103R|NTM_uc010scj.1_Missense_Mutation_p.Q62R|NTM_uc001qgo.2_Missense_Mutation_p.Q103R|NTM_uc001qgq.2_Missense_Mutation_p.Q103R	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	103	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						ATCGAGATCCAGAACGTGGAT	0.557			NA											9	74					0	0	0.004482	0	0
NCAPD3	23310	broad.mit.edu	37	11	134073739	134073739	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:134073739C>T	uc001qhd.1	-	11	1884	c.1278G>A	c.(1276-1278)GAG>GAA	p.E426E	NCAPD3_uc010scm.1_RNA|NCAPD3_uc009zda.1_RNA	NM_015261	NP_056076	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	426					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		TGTTATCCACCTCTCTTTCAG	0.438			NA											31	113					0	0	0.002096	0	0
C12orf32	83695	broad.mit.edu	37	12	2997093	2997093	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:2997093A>T	uc001qlh.2	+	3	353	c.185A>T	c.(184-186)GAT>GTT	p.D62V	TULP3_uc010sef.1_Intron|TULP3_uc009zec.1_5'Flank|TULP3_uc010seg.1_5'Flank|TULP3_uc001qlj.2_5'Flank|TULP3_uc010seh.1_5'Flank|TULP3_uc010sei.1_5'Flank|C12orf32_uc010see.1_Missense_Mutation_p.D48V|C12orf32_uc001qli.2_5'UTR	NR_027363				RecName: Full=Uncharacterized protein C12orf32;												0			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			CCTGATTTTGATACAGCAGCA	0.418			NA											7	14					0	0	0.001984	0	0
KCNA6	3742	broad.mit.edu	37	12	4919230	4919230	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:4919230C>T	uc001qng.2	+	1	889	c.23C>T	c.(22-24)ACG>ATG	p.T8M		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	8						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						AAATCCCTTACGCTGGCGGCG	0.716			NA								HNSCC(72;0.22)			9	42					0	0	0.004482	0	0
NTF3	4908	broad.mit.edu	37	12	5603685	5603685	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:5603685C>A	uc001qnl.3	+	1	388	c.305C>A	c.(304-306)CCG>CAG	p.P102Q	NTF3_uc001qnk.3_Missense_Mutation_p.P115Q	NM_002527	NP_002518	P20783	NTF3_HUMAN	neurotrophin 3 isoform 2 preproprotein	102					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			pancreas(1)	1						TACAACTCACCGCGGGTCCTG	0.642	GBM(194;1104 2182 8339 9578 18493)		NA											31	52					0.000409698	0.000464606	0.002445	1	0
NOP2	4839	broad.mit.edu	37	12	6669388	6669388	+	Silent	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:6669388T>A	uc001qph.1	-	15	1833	c.1653A>T	c.(1651-1653)CGA>CGT	p.R551R	NOP2_uc009zeq.1_Silent_p.R267R|NOP2_uc001qpi.1_Silent_p.R551R|NOP2_uc001qpj.1_5'UTR	NM_001033714	NP_001028886	P46087	NOP2_HUMAN	nucleolar protein 1, 120kDa	555					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			ovary(2)	2						AGCGCCTTTCTCGAAAGCGGG	0.502			NA											11	61					0	0	0.000978	0	0
ABCC9	10060	broad.mit.edu	37	12	21971084	21971084	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:21971084C>A	uc001rfi.1	-	30	3791	c.3771G>T	c.(3769-3771)ACG>ACT	p.T1257T	ABCC9_uc001rfh.2_Silent_p.T1257T|ABCC9_uc001rfj.1_Silent_p.T1221T	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1257	Helical; Name=15; (Potential).|ABC transmembrane type-1 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CCATACCTACCGTAAGTGCAT	0.254			NA											52	126					2.41709e-19	4.14051e-19	0.00361	1	0
ABCC9	10060	broad.mit.edu	37	12	22012543	22012543	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:22012543G>A	uc001rfi.1	-	20	2502	c.2482C>T	c.(2482-2484)CAA>TAA	p.Q828*	ABCC9_uc001rfh.2_Nonsense_Mutation_p.Q828*|ABCC9_uc001rfj.1_Nonsense_Mutation_p.Q792*	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	828	Cytoplasmic (Potential).|ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTGGTGTTTTGATACAGCGCT	0.408			NA											26	286					0	0	0.009535	0	0
TM7SF3	51768	broad.mit.edu	37	12	27129254	27129254	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:27129254C>G	uc010sjl.1	-	10	1464	c.1226G>C	c.(1225-1227)TGG>TCG	p.W409S		NM_016551	NP_057635	Q9NS93	TM7S3_HUMAN	transmembrane 7 superfamily member 3 precursor	409	Helical; (Potential).					integral to membrane|plasma membrane				upper_aerodigestive_tract(2)	2	Colorectal(261;0.0847)					GAAAGTGACCCAGAATACACC	0.343			NA											7	35					0	0	0.00308	0	0
OVCH1	341350	broad.mit.edu	37	12	29604465	29604465	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:29604465G>A	uc001rix.1	-	22	2568	c.2568C>T	c.(2566-2568)GGC>GGT	p.G856G		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	856	CUB 3.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					TGGGAAAAAAGCCTCTAGGCT	0.428			NA											11	27					0	0	0.00245	0	0
BICD1	636	broad.mit.edu	37	12	32491768	32491768	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:32491768G>T	uc001rku.2	+	8	2700	c.2619G>T	c.(2617-2619)GGG>GGT	p.G873G	BICD1_uc001rkv.2_Intron|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	873					anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			GGACTTCAGGGGCTTCCTACC	0.433			NA											68	111					1.43987e-31	2.68775e-31	0.00361	1	0
TMBIM6	7009	broad.mit.edu	37	12	50152023	50152023	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:50152023C>T	uc001rux.2	+	5	432	c.300C>T	c.(298-300)GGC>GGT	p.G100G	TMBIM6_uc010sml.1_Silent_p.G100G|TMBIM6_uc001ruy.2_Silent_p.G158G|TMBIM6_uc001ruz.2_Silent_p.G100G	NM_003217	NP_003208	P55061	BI1_HUMAN	testis enhanced gene transcript (BAX inhibitor	100	Helical; (Potential).				apoptosis|negative regulation of apoptosis	endoplasmic reticulum|insoluble fraction|integral to plasma membrane|nucleus					0						TTGGCCTGGGCCCTGCCCTGG	0.413			NA											81	142					0	0	0.00361	0	0
DIP2B	57609	broad.mit.edu	37	12	51100372	51100372	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:51100372G>T	uc001rwv.2	+	21	2614	c.2458G>T	c.(2458-2460)GGT>TGT	p.G820C	DIP2B_uc009zlt.2_Missense_Mutation_p.G250C	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	820						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						GATGGTTAGTGGTCGAAGACA	0.363			NA											31	54					4.40665e-25	7.90936e-25	0.009535	1	0
BIN2	51411	broad.mit.edu	37	12	51717914	51717914	+	Translation_Start_Site	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:51717914C>A	uc001ryg.2	-	1	25	c.-27G>T	c.(-29--25)CAGGG>CATGG		BIN2_uc009zlz.2_Translation_Start_Site|BIN2_uc001ryh.2_Translation_Start_Site|BIN2_uc010sng.1_Intron	NM_016293	NP_057377	Q9UBW5	BIN2_HUMAN	bridging integrator 2							cytoplasm	protein binding			ovary(1)	1						GGCCGCCGCCCTGGCCCCGCG	0.726			NA											11	17					3.07112e-06	3.80187e-06	0.000978	1	0
ACVR1B	91	broad.mit.edu	37	12	52369262	52369262	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:52369262A>G	uc001rzn.2	+	2	347	c.305A>G	c.(304-306)AAC>AGC	p.N102S	ACVR1B_uc001rzl.2_Missense_Mutation_p.N102S|ACVR1B_uc001rzm.2_Missense_Mutation_p.N102S|ACVR1B_uc010snn.1_Missense_Mutation_p.N102S	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	102	Extracellular (Potential).				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	GACTACTGCAACAGGATCGAC	0.562			NA											15	22					0	0	0.004007	0	0
KRT82	3888	broad.mit.edu	37	12	52799789	52799789	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:52799789G>A	uc001sai.1	-	1	388	c.273C>T	c.(271-273)TGC>TGT	p.C91C		NM_033033	NP_149022	Q9NSB4	KRT82_HUMAN	keratin 82	91	Head.					keratin filament	protein binding|structural constituent of epidermis			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.193)		CAGGGGTGATGCAGGCAGAAG	0.617			NA											30	49					0	0	0.009535	0	0
KRT74	121391	broad.mit.edu	37	12	52964617	52964617	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:52964617C>G	uc001sap.1	-	5	892	c.844G>C	c.(844-846)GAG>CAG	p.E282Q		NM_175053	NP_778223	Q7RTS7	K2C74_HUMAN	keratin 6 irs4	282	Coil 1B.|Rod.					keratin filament	structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.191)		TGAGCGATCTCCTGCATTGAG	0.577			NA											13	26					0	0	0.003163	0	0
HOXC13	3229	broad.mit.edu	37	12	54333267	54333267	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:54333267G>T	uc001sei.2	+	1	692	c.577G>T	c.(577-579)GTG>TTG	p.V193L	HOXC13_uc010sop.1_RNA	NM_017410	NP_059106	P31276	HXC13_HUMAN	homeobox C13	193						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						GGACGTGTCGGTGGTGCCCGG	0.672			NA	T	NUP98	AML								10	15					3.86212e-05	4.5402e-05	0.008291	1	0
TIMELESS	8914	broad.mit.edu	37	12	56823998	56823998	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:56823998C>T	uc001slf.2	-	10	1145	c.977G>A	c.(976-978)CGA>CAA	p.R326Q	TIMELESS_uc001slg.2_Missense_Mutation_p.R325Q	NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	326					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						GGACAGCTCTCGGGCGGCCTG	0.537			NA											7	54					0	0	0.006214	0	0
KIF5A	3798	broad.mit.edu	37	12	57970090	57970090	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:57970090C>A	uc001sor.1	+	19	2335	c.2127C>A	c.(2125-2127)GCC>GCA	p.A709A	KIF5A_uc010srr.1_Silent_p.A620A	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	709					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						ACCGGGAGGCCCATCACCGGC	0.607			NA											31	55					6.04164e-23	1.06577e-22	0.002096	1	0
SLC16A7	9194	broad.mit.edu	37	12	60168526	60168526	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:60168526C>T	uc001sqs.2	+	5	749	c.450C>T	c.(448-450)GCC>GCT	p.A150A	SLC16A7_uc001sqt.2_Silent_p.A150A|SLC16A7_uc001squ.2_Silent_p.A150A|SLC16A7_uc009zqi.2_Silent_p.A51A|SLC16A7_uc010ssi.1_Silent_p.A51A	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	150	Helical; (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	ATGGATTGGCCATGGCAGGAA	0.418			NA											27	45					0	0	0.003954	0	0
FRS2	10818	broad.mit.edu	37	12	69968531	69968531	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:69968531G>T	uc001suy.2	+	10	1833	c.1323G>T	c.(1321-1323)TTG>TTT	p.L441F	FRS2_uc001suz.2_Missense_Mutation_p.L441F|FRS2_uc009zrj.2_Missense_Mutation_p.L441F|FRS2_uc009zrk.2_Missense_Mutation_p.L441F	NM_006654	NP_006645	Q8WU20	FRS2_HUMAN	fibroblast growth factor receptor substrate 2	441					activation of MAPKK activity|activation of phospholipase C activity|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway	endomembrane system|endosome|integral to plasma membrane|membrane fraction	fibroblast growth factor receptor binding|insulin receptor binding|phosphatase activator activity|transmembrane receptor protein tyrosine kinase adaptor activity			prostate(1)|kidney(1)	2	Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.94e-18)|Lung(24;9.68e-05)|OV - Ovarian serous cystadenocarcinoma(12;0.000984)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			AGGTTGACTTGGAAGGTGGCA	0.483			NA											21	41					3.08376e-08	4.15849e-08	0.00333	1	0
LRRC10	376132	broad.mit.edu	37	12	70004436	70004436	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:70004436G>T	uc001svc.2	-	1	507	c.183C>A	c.(181-183)GAC>GAA	p.D61E		NM_201550	NP_963844	Q5BKY1	LRC10_HUMAN	leucine rich repeat containing 10	61	LRR 1.					nucleus					0	all_cancers(2;2.83e-105)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;1.98e-18)|GBM - Glioblastoma multiforme(2;7.43e-12)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			TGAGGTGGTTGTCGCTCAGGT	0.587			NA											14	24					4.7546e-09	6.62633e-09	0.004007	1	0
PTPRR	5801	broad.mit.edu	37	12	71094917	71094917	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:71094917C>T	uc001swi.1	-	7	1610	c.1194G>A	c.(1192-1194)ATG>ATA	p.M398I	PTPRR_uc001swh.1_Missense_Mutation_p.M153I|PTPRR_uc009zrs.2_Missense_Mutation_p.M247I|PTPRR_uc010stq.1_Missense_Mutation_p.M286I|PTPRR_uc010str.1_Missense_Mutation_p.M247I	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	398	Tyrosine-protein phosphatase.|Cytoplasmic (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		GAAGGCTCACCATGAATTCAC	0.443			NA											24	63					0	0	0.00333	0	0
C12orf26	84190	broad.mit.edu	37	12	82824732	82824732	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:82824732G>T	uc001szq.2	+	6	1361	c.1340G>T	c.(1339-1341)TGC>TTC	p.C447F		NM_032230	NP_115606	Q8N6Q8	CL026_HUMAN	hypothetical protein LOC84190	447											0						GAGAGATGGTGCTGTGGTCGT	0.368			NA											7	124					0.00307968	0.0033804	0.00308	1	0
LRRIQ1	84125	broad.mit.edu	37	12	85626515	85626515	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:85626515G>A	uc001tac.2	+	26	5108	c.4997G>A	c.(4996-4998)GGT>GAT	p.G1666D		NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1666										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		GTACTTAATGGTGGAAGAGTT	0.318			NA											7	45					0	0	0.004482	0	0
UBE2N	7334	broad.mit.edu	37	12	93804897	93804897	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:93804897C>A	uc001tcp.2	-	2	575	c.209G>T	c.(208-210)CGT>CTT	p.R70L		NM_003348	NP_003339	P61088	UBE2N_HUMAN	ubiquitin-conjugating enzyme E2N	70					DNA double-strand break processing|double-strand break repair via homologous recombination|histone ubiquitination|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of DNA repair|positive regulation of histone modification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity|postreplication repair|protein K63-linked ubiquitination|proteolysis|regulation of histone ubiquitination|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus|UBC13-MMS2 complex|UBC13-UEV1A complex|ubiquitin ligase complex	ATP binding|ubiquitin binding|ubiquitin-protein ligase activity				0						GGTCATGAAACGTACTTTAGG	0.388	Pancreas(197;738 2228 30225 32034 33454)		NA						Direct_reversal_of_damage|Rad6_pathway					43	63					8.20599e-20	1.40883e-19	0.002852	1	0
VEZT	55591	broad.mit.edu	37	12	95660204	95660205	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:95660204_95660205GG>TT	uc001tdz.2	+	5	611_612	c.506_507GG>TT	c.(505-507)TGG>TTT	p.W169F	VEZT_uc009zsy.1_Missense_Mutation_p.W11F|VEZT_uc001tdr.2_Missense_Mutation_p.W11F|VEZT_uc001tds.2_Missense_Mutation_p.W121F|VEZT_uc001tdt.2_Missense_Mutation_p.W121F|VEZT_uc009zsz.1_Missense_Mutation_p.W169F|VEZT_uc001tdv.2_Missense_Mutation_p.W138F|VEZT_uc001tdw.1_Missense_Mutation_p.W121F|VEZT_uc009zta.1_Missense_Mutation_p.W121F	NM_017599	NP_060069	Q9HBM0	VEZA_HUMAN	vezatin, adherens junctions transmembrane	169	Helical; (Potential).			W -> R (in Ref. 2; AAG38485).		acrosomal vesicle|adherens junction|integral to membrane|nucleus				ovary(1)	1						GTGTCTTCCTGGCTGGTATGGG	0.421			NA											172	233					0	0	0.004672	0	0
ANO4	121601	broad.mit.edu	37	12	101505439	101505439	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:101505439T>A	uc010svm.1	+	24	2973	c.2401T>A	c.(2401-2403)TAT>AAT	p.Y801N	ANO4_uc001thw.2_Missense_Mutation_p.Y766N|ANO4_uc001thx.2_Missense_Mutation_p.Y801N|ANO4_uc001thy.2_Missense_Mutation_p.Y321N	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	801	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						TCGCTTGGTGTATGCTTATAA	0.383			NA								HNSCC(74;0.22)			9	55					0	0	0.000978	0	0
PAH	5053	broad.mit.edu	37	12	103249050	103249050	+	Silent	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:103249050C>G	uc001tjq.1	-	7	1042	c.570G>C	c.(568-570)GTG>GTC	p.V190V	PAH_uc010swc.1_Silent_p.V190V	NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	190			V -> A (in PKU; haplotype 3).		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	GAGTCTTGAACACTGTGCCCC	0.438			NA											17	32					0	0	0.004007	0	0
CMKLR1	1240	broad.mit.edu	37	12	108686144	108686144	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:108686144C>A	uc009zuw.2	-	3	787	c.596G>T	c.(595-597)GGG>GTG	p.G199V	CMKLR1_uc001tmw.2_Missense_Mutation_p.G199V|CMKLR1_uc001tmv.2_Missense_Mutation_p.G197V|CMKLR1_uc009zuv.2_Missense_Mutation_p.G199V	NM_001142345	NP_001135817	Q99788	CML1_HUMAN	chemokine-like receptor 1 isoform a	199	Extracellular (Potential).				chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			lung(3)|ovary(1)|pancreas(1)	5						CGAGGAAGACCCAGGTGTGGA	0.567			NA											18	34					3.32936e-07	4.27981e-07	0.006122	1	0
SVOP	55530	broad.mit.edu	37	12	109316512	109316512	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:109316512C>G	uc010sxh.1	-	11	1282	c.1110G>C	c.(1108-1110)GAG>GAC	p.E370D		NM_018711	NP_061181	Q8N4V2	SVOP_HUMAN	SV2 related protein	370	Vesicular (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity				0						TGTAATCCTCCTCACTCAGGT	0.547			NA											4	4					0	0	0.000602	0	0
CCDC63	160762	broad.mit.edu	37	12	111330915	111330915	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:111330915G>C	uc001trv.1	+	9	1305	c.1110G>C	c.(1108-1110)TTG>TTC	p.L370F	CCDC63_uc010sye.1_Missense_Mutation_p.L330F|CCDC63_uc001trw.1_Missense_Mutation_p.L285F	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	370	Potential.									skin(6)|ovary(1)|pancreas(1)	8						AGCAGAAATTGTCCCACGATG	0.547			NA											34	53					0	0	0.004878	0	0
RBM19	9904	broad.mit.edu	37	12	114374902	114374902	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:114374902C>T	uc009zwi.2	-	16	2122	c.1978G>A	c.(1978-1980)GGC>AGC	p.G660S	RBM19_uc001tvn.3_Missense_Mutation_p.G660S|RBM19_uc001tvm.2_Missense_Mutation_p.G660S	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	660					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					GAGAAGACGCCAACTGGAGCC	0.542			NA											18	100					0	0	0.008871	0	0
TBX5	6910	broad.mit.edu	37	12	114823367	114823367	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:114823367C>A	uc001tvo.2	-	7	1164	c.669G>T	c.(667-669)ACG>ACT	p.T223T	TBX5_uc001tvp.2_Silent_p.T223T|TBX5_uc001tvq.2_Silent_p.T173T|TBX5_uc010syv.1_Silent_p.T223T	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	223	T-box.				cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TCTTTAATTGCGTGATCTGAA	0.418	NSCLC(152;1358 1980 4050 23898 40356)		NA											7	42					1.12685e-05	1.36427e-05	0.004482	1	0
NOS1	4842	broad.mit.edu	37	12	117681140	117681140	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:117681140C>T	uc001twm.1	-	19	3610	c.2924G>A	c.(2923-2925)CGC>CAC	p.R975H		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	975					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	AAAGGTGAGGCGGAACTTGTT	0.517	Esophageal Squamous(162;1748 2599 51982 52956)		NA											11	80					0	0	0.008291	0	0
TAOK3	51347	broad.mit.edu	37	12	118671561	118671561	+	Silent	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:118671561T>C	uc001twx.2	-	9	856	c.561A>G	c.(559-561)CCA>CCG	p.P187P	TAOK3_uc001tww.2_Silent_p.P17P|TAOK3_uc001twy.3_Silent_p.P187P	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	187	Protein kinase.				MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGATCACCTCTGGAGCCATCC	0.368			NA											23	36					0	0	0.00278	0	0
MPHOSPH9	10198	broad.mit.edu	37	12	123679134	123679134	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:123679134T>A	uc001uel.2	-	9	1691	c.1584A>T	c.(1582-1584)GAA>GAT	p.E528D	MPHOSPH9_uc010tal.1_5'UTR|MPHOSPH9_uc010tam.1_RNA|MPHOSPH9_uc001uem.2_5'UTR	NM_022782	NP_073619	Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	528	Potential.				M phase of mitotic cell cycle	centriole|Golgi membrane					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		CACTGAAGCGTTCTCTCAAAT	0.244			NA											12	23					0	0	0.00245	0	0
SLC15A4	121260	broad.mit.edu	37	12	129294610	129294610	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:129294610C>G	uc001uhu.2	-	3	942	c.889G>C	c.(889-891)GAT>CAT	p.D297H	SLC15A4_uc001uhv.2_Intron	NM_145648	NP_663623	Q8N697	S15A4_HUMAN	solute carrier family 15, member 4	297					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.69e-06)|Epithelial(86;1.17e-05)|all cancers(50;5.07e-05)		TTACATGAATCAAACAGACTT	0.393			NA											7	77					0	0	0.004482	0	0
GPR133	283383	broad.mit.edu	37	12	131605422	131605422	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:131605422C>T	uc001uit.3	+	20	2698	c.2139C>T	c.(2137-2139)ATC>ATT	p.I713I	GPR133_uc010tbm.1_Silent_p.I745I|GPR133_uc009zyo.2_Intron|GPR133_uc009zyp.2_RNA	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	713	Helical; Name=5; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GTGGCGCCATCTGGGCCTTTG	0.612			NA											15	114					0	0	0.003163	0	0
ZNF268	10795	broad.mit.edu	37	12	133768558	133768558	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr12:133768558G>T	uc010tcf.1	+	5	756	c.426G>T	c.(424-426)GTG>GTT	p.V142V	ZNF268_uc010tbv.1_5'UTR|ZNF268_uc010tbw.1_Intron|ZNF268_uc010tbx.1_Silent_p.V2V|ZNF268_uc010tby.1_Intron|ZNF268_uc010tbz.1_5'UTR|ZNF268_uc010tca.1_5'UTR|ZNF268_uc010tcb.1_Silent_p.V2V|ZNF268_uc010tcc.1_5'UTR|ZNF268_uc010tcd.1_5'UTR|ZNF268_uc010tce.1_Intron|ZNF268_uc010tcg.1_5'UTR|ZNF268_uc010tch.1_Silent_p.V142V	NM_003415	NP_003406	Q14587	ZN268_HUMAN	zinc finger protein 268 isoform a	142	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.000215)|all_epithelial(31;0.096)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		TGTGTATGGTGCAGGCCCAAG	0.398			NA											40	96					2.27781e-18	3.87177e-18	0.00361	1	0
TUBA3C	7278	broad.mit.edu	37	13	19752452	19752452	+	Nonsense_Mutation	SNP	G	G	T	rs114178008		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:19752452G>T	uc009zzj.2	-	3	358	c.309C>A	c.(307-309)TAC>TAA	p.Y103*		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	103					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		GGCCTCTGGCGTAATTATTGG	0.527			NA											15	131					3.27435e-08	4.40009e-08	0.00245	1	0
SKA3	221150	broad.mit.edu	37	13	21742417	21742417	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:21742417C>A	uc001unt.2	-	4	547	c.453G>T	c.(451-453)AAG>AAT	p.K151N	SKA3_uc001unv.2_Missense_Mutation_p.K69N|SKA3_uc001unu.2_Missense_Mutation_p.K151N	NM_145061	NP_659498	Q8IX90	SKA3_HUMAN	SKA3	151					cell division|chromosome segregation|mitosis|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytoplasm|spindle microtubule	protein binding				0						TACGTGGAGACTTCTCAGAAA	0.428			NA											18	128					3.52763e-06	4.3565e-06	0.00499	1	0
SACS	26278	broad.mit.edu	37	13	23906719	23906719	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:23906719C>A	uc001uon.2	-	10	11885	c.11296G>T	c.(11296-11298)GTA>TTA	p.V3766L	SACS_uc001uoo.2_Missense_Mutation_p.V3619L|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3766					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTAGTTTTTACCATTTCTTCA	0.363			NA											11	47					1.58986e-06	2.00195e-06	0.008291	1	0
PABPC3	5042	broad.mit.edu	37	13	25671349	25671349	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:25671349T>A	uc001upy.2	+	1	1074	c.1013T>A	c.(1012-1014)GTA>GAA	p.V338E		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	338	RRM 4.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		TTTGGTTTTGTATGTTTCTCC	0.438			NA											43	152					0	0	0.002852	0	0
MAB21L1	4081	broad.mit.edu	37	13	36049377	36049377	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:36049377A>G	uc001uvc.2	-	1	1456	c.899T>C	c.(898-900)CTG>CCG	p.L300P	NBEA_uc001uvb.2_Intron|NBEA_uc010abi.2_Intron|NBEA_uc010tee.1_Intron|NBEA_uc010tef.1_5'Flank|NBEA_uc010teg.1_5'Flank	NM_005584	NP_005575	Q13394	MB211_HUMAN	mab-21-like protein 1	300					anatomical structure morphogenesis	nucleus				ovary(2)	2		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		AATCCCGTTCAGCCGATCACC	0.517			NA											13	75					0	0	0.00245	0	0
CCNA1	8900	broad.mit.edu	37	13	37012875	37012875	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:37012875G>T	uc001uvr.3	+	5	1114	c.764G>T	c.(763-765)GGG>GTG	p.G255V	CCNA1_uc010teo.1_Missense_Mutation_p.G211V|CCNA1_uc010abq.2_Missense_Mutation_p.G211V|CCNA1_uc010abp.2_Missense_Mutation_p.G211V|CCNA1_uc001uvs.3_Missense_Mutation_p.G254V|CCNA1_uc010abr.2_Intron	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	255					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		GTGGAGGTTGGGGAAGAATAT	0.502			NA											8	57					1.26484e-09	1.79361e-09	0.00308	1	0
POSTN	10631	broad.mit.edu	37	13	38154834	38154834	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:38154834C>A	uc001uwo.3	-	11	1511	c.1393G>T	c.(1393-1395)GCT>TCT	p.A465S	POSTN_uc010tet.1_5'UTR|POSTN_uc001uwp.3_Missense_Mutation_p.A465S|POSTN_uc001uwr.2_Missense_Mutation_p.A465S|POSTN_uc001uwq.2_Missense_Mutation_p.A465S|POSTN_uc010teu.1_Missense_Mutation_p.A465S|POSTN_uc010tev.1_Missense_Mutation_p.A465S|POSTN_uc010tew.1_Missense_Mutation_p.A465S|POSTN_uc010tex.1_Missense_Mutation_p.A380S	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	465	FAS1 3.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		ATGCAGACAGCCTAGGAAAGG	0.438			NA											28	92					1.7367e-05	2.07972e-05	0.00632	1	0
LHFP	10186	broad.mit.edu	37	13	40174972	40174972	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:40174972C>A	uc001uxf.2	-	2	893	c.382G>T	c.(382-384)GGG>TGG	p.G128W		NM_005780	NP_005771	Q9Y693	LHFP_HUMAN	lipoma HMGIC fusion partner precursor	128	Helical; (Potential).					integral to membrane	DNA binding		HMGA2/LHFP(2)	soft_tissue(2)|lung(1)|breast(1)	4		Lung NSC(96;3.55e-06)|Breast(139;0.00408)|Ovarian(182;0.0107)|Prostate(109;0.0118)|Lung SC(185;0.0719)|Hepatocellular(188;0.114)		OV - Ovarian serous cystadenocarcinoma(117;6.48e-46)|Epithelial(112;8.43e-42)|all cancers(112;1.42e-36)|GBM - Glioblastoma multiforme(144;0.00187)|BRCA - Breast invasive adenocarcinoma(63;0.00886)|KIRC - Kidney renal clear cell carcinoma(186;0.048)|Kidney(163;0.0601)|LUSC - Lung squamous cell carcinoma(192;0.105)		CACTTACCCCCAAGAAACTGA	0.473			NA	T	HMGA2	lipoma								24	87					2.44723e-14	3.90543e-14	0.004656	1	0
KBTBD6	89890	broad.mit.edu	37	13	41705439	41705439	+	Silent	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:41705439T>C	uc001uxu.1	-	1	1498	c.1209A>G	c.(1207-1209)ACA>ACG	p.T403T	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Silent_p.T337T|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	403	Kelch 1.						protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		CCCAGAGGTCTGTCCTGGGCT	0.502			NA											6	121					0	0	0.001984	0	0
HTR2A	3356	broad.mit.edu	37	13	47409239	47409239	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:47409239G>A	uc001vbq.2	-	3	1283	c.1149C>T	c.(1147-1149)TTC>TTT	p.F383F	HTR2A_uc001vbr.2_Silent_p.F283F|HTR2A_uc010acr.2_Silent_p.F383F	NM_000621	NP_000612	P28223	5HT2A_HUMAN	5-hydroxytryptamine receptor 2A isoform 1	383	Helical; Name=7; (By similarity).				ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	AGGTCTTGTTGAACAGTGTGT	0.423			NA											5	76					0	0	0.000602	0	0
FNDC3A	22862	broad.mit.edu	37	13	49777385	49777385	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:49777385C>T	uc001vcm.2	+	25	3552	c.3247C>T	c.(3247-3249)CAA>TAA	p.Q1083*	FNDC3A_uc001vcn.2_Nonsense_Mutation_p.Q1083*|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcq.2_Nonsense_Mutation_p.Q1027*	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	1083	Fibronectin type-III 9.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		TTACAGTCTTCAAGTTATGTT	0.323			NA											7	81					0	0	0.004482	0	0
CAB39L	81617	broad.mit.edu	37	13	49951249	49951249	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:49951249T>C	uc001vcw.2	-	3	628	c.130A>G	c.(130-132)AAA>GAA	p.K44E	CAB39L_uc001vcx.2_Missense_Mutation_p.K44E|CAB39L_uc010adf.2_Missense_Mutation_p.K41E	NM_030925	NP_112187	Q9H9S4	CB39L_HUMAN	calcium binding protein 39-like	44					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	protein binding				0		Lung NSC(96;2.11e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.66e-09)|COAD - Colon adenocarcinoma(199;0.226)		TGCAGTGATTTAGACACTTCT	0.393			NA											15	62					0	0	0.003163	0	0
ATP7B	540	broad.mit.edu	37	13	52520526	52520526	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:52520526C>A	uc001vfw.2	-	13	3111	c.2954G>T	c.(2953-2955)TGC>TTC	p.C985F	ATP7B_uc010adv.2_Missense_Mutation_p.C555F|ATP7B_uc001vfx.2_Missense_Mutation_p.C778F|ATP7B_uc001vfy.2_Missense_Mutation_p.C874F|ATP7B_uc010tgt.1_Intron|ATP7B_uc010tgu.1_Missense_Mutation_p.C937F|ATP7B_uc010tgv.1_Missense_Mutation_p.C907F|ATP7B_uc001vfv.2_Missense_Mutation_p.C257F|ATP7B_uc010tgs.1_Missense_Mutation_p.C257F	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	985	Helical; (Potential).		C -> Y (in WD).		ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		CCCCAGGGAGCAGGGGCAGGC	0.627			NA							Wilson_disease				8	37					1.12685e-05	1.36427e-05	0.004482	1	0
NEK5	341676	broad.mit.edu	37	13	52693477	52693477	+	Silent	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:52693477T>A	uc001vge.2	-	4	332	c.192A>T	c.(190-192)GTA>GTT	p.V64V	NEK5_uc001vgf.2_Silent_p.V64V	NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	64	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		TGAAGAAGGCTACAATGTTGG	0.303			NA											5	35					0	0	0.000602	0	0
OLFM4	10562	broad.mit.edu	37	13	53608516	53608516	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:53608516C>T	uc001vhl.2	+	2	238	c.238C>T	c.(238-240)CGT>TGT	p.R80C	OLFM4_uc001vhk.1_Missense_Mutation_p.R80C	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	80					cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		CGTGGATGACCGTGGGACCTG	0.478			NA											8	90					0	0	0.004482	0	0
PCDH17	27253	broad.mit.edu	37	13	58240910	58240910	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:58240910G>A	uc001vhq.1	+	3	3632	c.2740G>A	c.(2740-2742)GTT>ATT	p.V914I	PCDH17_uc010aec.1_Missense_Mutation_p.V913I|PCDH17_uc001vhr.1_Missense_Mutation_p.V3I	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	914	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TGACATGTCTGTTAGGGAGGC	0.483	Melanoma(72;952 1291 1619 12849 33676)		NA											9	41					0	0	0.006214	0	0
DACH1	1602	broad.mit.edu	37	13	72133996	72133996	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:72133996A>T	uc010thn.1	-	6	1814	c.1391T>A	c.(1390-1392)GTG>GAG	p.V464E	DACH1_uc010tho.1_Intron|DACH1_uc010thp.1_Intron	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	516					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		GGAGCTGGACACGCTGCTGCT	0.552			NA											7	39					0	0	0.001984	0	0
RBM26	64062	broad.mit.edu	37	13	79929484	79929484	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:79929484G>A	uc001vkz.2	-	12	1754	c.1740C>T	c.(1738-1740)ATC>ATT	p.I580I	RBM26_uc001vky.2_Silent_p.I575I|RBM26_uc001vla.2_Silent_p.I575I|RBM26_uc010tia.1_5'Flank|RBM26_uc001vkx.2_Silent_p.I287I	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	575	RRM 1.				mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		TTGCAAATTGGATTAGGGCAC	0.343			NA											4	55					0	0	0.009096	0	0
SPRY2	10253	broad.mit.edu	37	13	80911103	80911103	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:80911103C>A	uc001vli.2	-	2	1716	c.738G>T	c.(736-738)CAG>CAT	p.Q246H	SPRY2_uc001vlj.2_Missense_Mutation_p.Q246H	NM_005842	NP_005833	O43597	SPY2_HUMAN	sprouty 2	246	SPR.|Cys-rich.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of gene expression|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein kinase B signaling cascade	cytosol|microtubule|ruffle membrane	protein serine/threonine kinase activator activity			ovary(1)|lung(1)	2	Medulloblastoma(90;0.18)	Acute lymphoblastic leukemia(28;0.218)|Breast(118;0.244)		GBM - Glioblastoma multiforme(99;0.0318)		AACAGTGAGACTGGCTGCAAG	0.463			NA											21	69					4.35082e-09	6.08561e-09	0.010504	1	0
SPRY2	10253	broad.mit.edu	37	13	80911650	80911650	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:80911650C>A	uc001vli.2	-	2	1169	c.191G>T	c.(190-192)AGA>ATA	p.R64I	SPRY2_uc001vlj.2_Missense_Mutation_p.R64I	NM_005842	NP_005833	O43597	SPY2_HUMAN	sprouty 2	64					epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of gene expression|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein kinase B signaling cascade	cytosol|microtubule|ruffle membrane	protein serine/threonine kinase activator activity			ovary(1)|lung(1)	2	Medulloblastoma(90;0.18)	Acute lymphoblastic leukemia(28;0.218)|Breast(118;0.244)		GBM - Glioblastoma multiforme(99;0.0318)		GAGCCCAGGTCTTGGGACGAC	0.597			NA											14	79					4.36969e-10	6.30677e-10	0.001855	1	0
SLITRK1	114798	broad.mit.edu	37	13	84454950	84454951	+	Missense_Mutation	DNP	GG	GG	CT			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:84454950_84454951GG>CT	uc001vlk.2	-	1	1578_1579	c.692_693CC>AG	c.(691-693)CCC>CAG	p.P231Q		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	231	Extracellular (Potential).|LRRCT 1.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GGGCATTCTTGGGAATGTTTTC	0.52			NA											13	63					0	0	0.004672	0	0
SLITRK6	84189	broad.mit.edu	37	13	86368425	86368425	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:86368425G>T	uc001vll.1	-	2	2678	c.2219C>A	c.(2218-2220)ACG>AAG	p.T740K	SLITRK6_uc010afe.1_Missense_Mutation_p.T193K	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	740	Cytoplasmic (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TGATTGGTTCGTGGTTTTGTA	0.368			NA											52	269					2.74695e-27	4.98857e-27	0.00361	1	0
SLITRK5	26050	broad.mit.edu	37	13	88329046	88329046	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:88329046G>T	uc001vln.2	+	2	1622	c.1403G>T	c.(1402-1404)AGG>ATG	p.R468M	SLITRK5_uc010tic.1_Missense_Mutation_p.R227M	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	468	LRR 9.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					AATGGCAACAGGATCGAGAGG	0.552			NA											10	47					3.86212e-05	4.5402e-05	0.008291	1	0
GPC6	10082	broad.mit.edu	37	13	94958244	94958244	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:94958244G>A	uc001vlt.2	+	6	1651	c.1019G>A	c.(1018-1020)GGA>GAA	p.G340E	GPC6_uc010tig.1_Missense_Mutation_p.G340E	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	340						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				GTCTTTCAGGGATGTGGTCAG	0.448			NA											24	251					0	0	0.003954	0	0
TGDS	23483	broad.mit.edu	37	13	95235491	95235491	+	Splice_Site	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:95235491C>G	uc001vlw.2	-	5	435	c.314_splice	c.e5-1	p.D105_splice	TGDS_uc001vlx.2_Splice_Site	NM_014305	NP_055120	O95455	TGDS_HUMAN	TDP-glucose 4,6-dehydratase						cellular metabolic process		coenzyme binding|dTDP-glucose 4,6-dehydratase activity|protein binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					AATGAAAGATCTAAAAGAAAA	0.383			NA											3	10					0	0	0.004672	0	0
CLDN10	9071	broad.mit.edu	37	13	96230256	96230256	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:96230256T>A	uc001vmh.2	+	5	736	c.675T>A	c.(673-675)AAT>AAA	p.N225K	CLDN10_uc001vmg.2_Missense_Mutation_p.N223K|CLDN10_uc010tii.1_Missense_Mutation_p.N204K|DZIP1_uc010afn.2_Intron	NM_006984	NP_008915	P78369	CLD10_HUMAN	claudin 10 isoform b	225	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)			TTGATAAAAATGCTTATGTCT	0.403			NA											6	27					0	0	0.001168	0	0
DZIP1	22873	broad.mit.edu	37	13	96264337	96264337	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:96264337T>A	uc001vmk.2	-	11	2120	c.1268A>T	c.(1267-1269)CAG>CTG	p.Q423L	DZIP1_uc001vml.2_Missense_Mutation_p.Q423L	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	423	Potential.				germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			CTGGAGTCTCTGCCCTagctc	0.343			NA											26	132					0	0	0.003954	0	0
DZIP1	22873	broad.mit.edu	37	13	96272140	96272140	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:96272140C>G	uc001vmk.2	-	10	2024	c.1172G>C	c.(1171-1173)CGG>CCG	p.R391P	DZIP1_uc001vml.2_Missense_Mutation_p.R391P	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	391					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			TAACCTTACCCGACCCTTCTC	0.318			NA											16	120					0	0	0.004007	0	0
HS6ST3	266722	broad.mit.edu	37	13	97484870	97484870	+	Silent	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:97484870A>G	uc001vmw.2	+	2	858	c.834A>G	c.(832-834)CCA>CCG	p.P278P		NM_153456	NP_703157	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	278	Lumenal (Potential).					integral to membrane	sulfotransferase activity			ovary(1)|skin(1)	2	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					GCCCCACCCCAGATGAGCTGC	0.552			NA											8	35					0	0	0.004482	0	0
SLC15A1	6564	broad.mit.edu	37	13	99364135	99364135	+	Silent	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:99364135T>A	uc001vno.2	-	11	950	c.873A>T	c.(871-873)CCA>CCT	p.P291P		NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	291	Helical; (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	CCCAGAACATTGGGAGTGGAA	0.517			NA											23	87					0	0	0.005443	0	0
PCCA	5095	broad.mit.edu	37	13	100925601	100925601	+	Splice_Site	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:100925601G>T	uc001voo.2	+	12	1103	c.1065_splice	c.e12+1	p.Q355_splice	PCCA_uc010aga.2_Splice_Site_p.Q329_splice|PCCA_uc010tiz.1_Splice_Site_p.Q355_splice	NM_000282	NP_000273	P05165	PCCA_HUMAN	propionyl-Coenzyme A carboxylase, alpha						fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			skin(2)	2	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	AAGACTCCAGGTAACAACAAC	0.363			NA											4	41					0.00909568	0.00983662	0.009096	1	0
NALCN	259232	broad.mit.edu	37	13	101714351	101714351	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:101714351C>A	uc001vox.1	-	41	4913	c.4724G>T	c.(4723-4725)TGG>TTG	p.W1575L		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1575	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTTCTTGAGCCACATGCGGAT	0.498			NA											20	44					7.41877e-09	1.0265e-08	0.001882	1	0
FGF14	2259	broad.mit.edu	37	13	102375181	102375181	+	Nonstop_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:102375181C>A	uc001vpe.2	-	5	744	c.744G>T	c.(742-744)TAG>TAT	p.*248Y	FGF14_uc001vpf.2_Nonstop_Mutation_p.*253Y|FGF14_uc001vpd.1_5'Flank	NM_004115	NP_004106	Q92915	FGF14_HUMAN	fibroblast growth factor 14 isoform 1A	248					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			ovary(2)|lung(1)|large_intestine(1)	4	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GAGGATCTGGCTATGTTGTCT	0.502			NA											14	44					2.61681e-11	3.89738e-11	0.00245	1	0
ING1	3621	broad.mit.edu	37	13	111371668	111371668	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:111371668G>T	uc001vri.2	+	2	1090	c.658G>T	c.(658-660)GCG>TCG	p.A220S	ING1_uc001vrf.2_Missense_Mutation_p.A33S|ING1_uc001vrg.2_Missense_Mutation_p.A8S|ING1_uc001vrh.2_Missense_Mutation_p.A77S	NM_005537	NP_005528	Q9UK53	ING1_HUMAN	inhibitor of growth family, member 1 isoform D	220					cell cycle|negative regulation of cell growth|negative regulation of cell proliferation	nucleus	zinc ion binding			ovary(1)	1	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.188)			TGTGCAGCGCGCGCTGATCCG	0.652			NA											19	55					9.7654e-05	0.000113243	0.007413	1	0
MCF2L	23263	broad.mit.edu	37	13	113729424	113729424	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:113729424G>T	uc001vsu.2	+	11	1422	c.1400G>T	c.(1399-1401)TGT>TTT	p.C467F	MCF2L_uc001vsq.2_Missense_Mutation_p.C467F|MCF2L_uc010tjr.1_Missense_Mutation_p.C410F|MCF2L_uc001vsr.2_Missense_Mutation_p.C414F|MCF2L_uc001vss.3_Missense_Mutation_p.C408F|MCF2L_uc010tjs.1_Missense_Mutation_p.C408F|MCF2L_uc001vst.1_Missense_Mutation_p.C372F	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	440	Spectrin.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				CGGCACCTCTGTGACCAGTTC	0.667			NA											13	68					7.03913e-09	9.75721e-09	0.001368	1	0
CUL4A	8451	broad.mit.edu	37	13	113897369	113897369	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:113897369G>A	uc010tjy.1	+	12	1134	c.1123G>A	c.(1123-1125)GTG>ATG	p.V375M	CUL4A_uc010tjx.1_Missense_Mutation_p.V275M|CUL4A_uc010agu.2_Missense_Mutation_p.V236M|CUL4A_uc010tjz.1_Missense_Mutation_p.V54M	NM_001008895	NP_001008895	Q13619	CUL4A_HUMAN	cullin 4A isoform 1	375					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			central_nervous_system(2)|skin(1)	3	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			GGTGGACCACGTGATCGAGGT	0.468			NA											17	66					0	0	0.006122	0	0
POTEG	404785	broad.mit.edu	37	14	19553607	19553607	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:19553607G>T	uc001vuz.1	+	1	243	c.191G>T	c.(190-192)TGG>TTG	p.W64L	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	64										ovary(1)	1						ATGGGCAAGTGGTGCCGCCAC	0.597			NA											99	629					3.82405e-32	7.16428e-32	0.00361	1	0
P704P	641455	broad.mit.edu	37	14	20019993	20019993	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:20019993G>T	uc001vwc.3	-	1	280	c.228C>A	c.(226-228)GGC>GGA	p.G76G	P704P_uc001vwb.3_RNA	NM_001145442	NP_001138914	A6NI47	POTEM_HUMAN	prostate-specific P704P	76											0						CGTTGCTCTTGCCGCTCCCCC	0.587			NA											39	537					6.3091e-27	1.14306e-26	0.00361	1	0
OR4Q3	441669	broad.mit.edu	37	14	20216396	20216396	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:20216396G>A	uc010tkt.1	+	1	810	c.810G>A	c.(808-810)AAG>AAA	p.K270K		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	270	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTGTGGATAAGATATTCTCCT	0.438			NA											10	290					0	0	0.000978	0	0
OR4K2	390431	broad.mit.edu	37	14	20345226	20345226	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:20345226C>G	uc001vwh.1	+	1	800	c.800C>G	c.(799-801)ACA>AGA	p.T267R		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGCTTTCTCACAGACAAGATT	0.398			NA											27	130					0	0	0.005443	0	0
OR4K14	122740	broad.mit.edu	37	14	20482658	20482658	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:20482658C>A	uc010tky.1	-	1	695	c.695G>T	c.(694-696)GGT>GTT	p.G232V		NM_001004712	NP_001004712	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GGATGTGCTACCGGCAGCACG	0.498			NA											19	22					2.4624e-09	3.4631e-09	0.008871	1	0
OR4L1	122742	broad.mit.edu	37	14	20528892	20528892	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:20528892C>T	uc001vwn.1	+	1	689	c.689C>T	c.(688-690)TCA>TTA	p.S230L		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		AAAAAATCATCACATGGGCTC	0.438			NA											71	118					0	0	0.00361	0	0
TEP1	7011	broad.mit.edu	37	14	20845891	20845891	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:20845891G>A	uc001vxe.2	-	40	5783	c.5743C>T	c.(5743-5745)CTG>TTG	p.L1915L	TEP1_uc010ahk.2_Silent_p.L1258L|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Silent_p.L1807L|TEP1_uc010tlh.1_Silent_p.L253L	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1915	WD 7.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGCCGACCCAGAGACCCTGAC	0.597			NA											36	47					0	0	0.003755	0	0
TEP1	7011	broad.mit.edu	37	14	20872001	20872001	+	Missense_Mutation	SNP	C	C	A	rs34770935	byFrequency	TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:20872001C>A	uc001vxe.2	-	6	1115	c.1075G>T	c.(1075-1077)GCC>TCC	p.A359S	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Intron	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	359	TROVE.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CGGAGACAGGCGGGCAGGGGC	0.557			NA											8	145					0.00448238	0.00488872	0.004482	1	0
OSGEP	55644	broad.mit.edu	37	14	20917122	20917122	+	Splice_Site	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:20917122C>A	uc001vxf.2	-	5	913	c.557_splice	c.e5+1	p.R186_splice		NM_017807	NP_060277	Q9NPF4	OSGEP_HUMAN	O-sialoglycoprotein endopeptidase						proteolysis|tRNA processing		metal ion binding|metalloendopeptidase activity|protein binding				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0231)|READ - Rectum adenocarcinoma(17;0.196)		TGTCCCCTTACCGCTTTGCCA	0.458			NA											18	241					1.33834e-09	1.89434e-09	0.007413	1	0
MYH6	4624	broad.mit.edu	37	14	23867979	23867979	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:23867979G>A	uc001wjv.2	-	15	1916	c.1849C>T	c.(1849-1851)CTC>TTC	p.L617F		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	617	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GTGGCCATGAGCTTGAGGGAG	0.577			NA											6	109					0	0	0.001984	0	0
FITM1	161247	broad.mit.edu	37	14	24601569	24601569	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:24601569G>T	uc001wmf.2	+	2	514	c.416G>T	c.(415-417)GGC>GTC	p.G139V		NM_203402	NP_981947	A5D6W6	FITM1_HUMAN	fat-inducing transcript 1	139	Extracellular (Potential).				lipid particle organization|positive regulation of sequestering of triglyceride	endoplasmic reticulum membrane|integral to membrane					0						CGGGGAGCCGGCCGGGCCTTC	0.667			NA											21	32					2.89027e-11	4.29634e-11	0.002299	1	0
CMA1	1215	broad.mit.edu	37	14	24976618	24976618	+	Silent	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:24976618A>G	uc001wpp.1	-	2	183	c.153T>C	c.(151-153)TGT>TGC	p.C51C	CMA1_uc010alx.1_Intron	NM_001836	NP_001827	P23946	CMA1_HUMAN	chymase 1, mast cell preproprotein	51	Peptidase S1.				interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.0271)		GGAAACCACCACAAAATTTTG	0.488			NA											64	115					0	0	0.00361	0	0
NOVA1	4857	broad.mit.edu	37	14	26917470	26917470	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:26917470C>A	uc001wpy.2	-	5	1537	c.1219G>T	c.(1219-1221)GCC>TCC	p.A407S	NOVA1_uc001wpz.2_Missense_Mutation_p.A383S|NOVA1_uc001wqa.2_Missense_Mutation_p.A285S	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	410	Ala-rich.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		ATGGCACTGGCAGCTAGGGGA	0.498			NA											22	40					1.10513e-12	1.69681e-12	0.002299	1	0
AKAP6	9472	broad.mit.edu	37	14	33293232	33293232	+	Silent	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:33293232A>G	uc001wrq.2	+	13	6383	c.6213A>G	c.(6211-6213)CTA>CTG	p.L2071L		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	2071	PKA-RII subunit binding domain.				protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CGACAGCCCTAAAAAGTAAAT	0.433	Melanoma(49;821 1200 7288 13647 42351)		NA											5	59					0	0	0.001168	0	0
DDHD1	80821	broad.mit.edu	37	14	53570567	53570567	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:53570567A>C	uc001xai.2	-	2	1076	c.846T>G	c.(844-846)GAT>GAG	p.D282E	DDHD1_uc001xaj.2_Missense_Mutation_p.D282E|DDHD1_uc001xah.2_Missense_Mutation_p.D282E	NM_001160148	NP_001153620	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1 isoform c	282					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)					CTGGTATTTTATCAGCCTCTG	0.358			NA											5	31					0	0	0.000602	0	0
BMP4	652	broad.mit.edu	37	14	54416766	54416766	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:54416766C>A	uc001xal.3	-	3	1398	c.1211G>T	c.(1210-1212)GGA>GTA	p.G404V	BMP4_uc010aoh.2_Missense_Mutation_p.G404V|BMP4_uc001xao.3_Missense_Mutation_p.G404V|BMP4_uc001xan.3_Missense_Mutation_p.G404V	NM_130851	NP_570912	P12644	BMP4_HUMAN	bone morphogenetic protein 4 preproprotein	404					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity				0						GCACCCACATCCCTCTACTAC	0.398			NA											21	36					8.10497e-08	1.07323e-07	0.010504	1	0
SGPP1	81537	broad.mit.edu	37	14	64152941	64152941	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:64152941C>T	uc001xgj.2	-	3	1302	c.1208G>A	c.(1207-1209)CGA>CAA	p.R403Q		NM_030791	NP_110418	Q9BX95	SGPP1_HUMAN	sphingosine-1-phosphate phosphatase 1	403						endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0056)|all cancers(60;0.0141)|BRCA - Breast invasive adenocarcinoma(234;0.103)		TCTTGCTTTTCGAATATCATC	0.348			NA											6	103					0	0	0.001168	0	0
SYNE2	23224	broad.mit.edu	37	14	64653253	64653253	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:64653253C>T	uc001xgm.2	+	97	17898	c.17668C>T	c.(17668-17670)CAA>TAA	p.Q5890*	SYNE2_uc001xgl.2_Nonsense_Mutation_p.Q5890*|SYNE2_uc010apy.2_Nonsense_Mutation_p.Q2275*|SYNE2_uc001xgn.2_Nonsense_Mutation_p.Q852*|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_5'UTR|SYNE2_uc001xgq.2_Nonsense_Mutation_p.Q255*	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5890	Spectrin 4.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTTGAAGGAGCAAATAGAGCA	0.483			NA											14	140					0	0	0.003163	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713178	70713178	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:70713178C>T	uc010ttg.1	-	1	1341	c.690G>A	c.(688-690)TTG>TTA	p.L230L		NR_003951				SubName: Full=ADAM21-like protein;												0						AGATTTCCCCCAATCTTGGAG	0.448			NA											31	52					0	0	0.002096	0	0
YLPM1	56252	broad.mit.edu	37	14	75269332	75269332	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:75269332C>G	uc001xqj.3	+	6	4598	c.4474C>G	c.(4474-4476)CAG>GAG	p.Q1492E	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	1297					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		TCTACCACCTCAGGAATCAAG	0.403			NA											6	57					0	0	0.001168	0	0
GPR65	8477	broad.mit.edu	37	14	88477441	88477441	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:88477441C>T	uc001xvv.2	+	2	780	c.250C>T	c.(250-252)CCT>TCT	p.P84S		NM_003608	NP_003599	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	84	Extracellular (Potential).				actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity				0						GACTTTCTCTCCTGCCTTGTG	0.403			NA											61	119					0	0	0.00361	0	0
SERPINA11	256394	broad.mit.edu	37	14	94914523	94914523	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:94914523G>T	uc001ydd.1	-	2	649	c.589C>A	c.(589-591)CCG>ACG	p.P197T		NM_001080451	NP_001073920	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1	197					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)	1				COAD - Colon adenocarcinoma(157;0.211)		CTGAACTCCGGGAGGCAGTCC	0.458			NA											56	101					2.73381e-35	5.14678e-35	0.00361	1	0
C14orf49	161176	broad.mit.edu	37	14	95910916	95910916	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:95910916T>A	uc001yei.3	-	9	1697	c.1682A>T	c.(1681-1683)CAG>CTG	p.Q561L	C14orf49_uc010avi.2_Missense_Mutation_p.Q561L|C14orf49_uc001yej.1_Missense_Mutation_p.Q561L	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	561	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		GAGCTTCCTCTGCAGGGGCTC	0.577			NA											6	34					0	0	0.001168	0	0
ATG2B	55102	broad.mit.edu	37	14	96807883	96807883	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:96807883C>T	uc001yfi.2	-	6	1265	c.900G>A	c.(898-900)CAG>CAA	p.Q300Q		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	300										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		GCACTTCATTCTGTTTCAACG	0.398			NA											60	104					0	0	0.00361	0	0
TECPR2	9895	broad.mit.edu	37	14	102964478	102964478	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:102964478G>T	uc001ylw.1	+	20	4268	c.4120G>T	c.(4120-4122)GGC>TGC	p.G1374C	TECPR2_uc010txx.1_Missense_Mutation_p.G537C	NM_014844	NP_055659	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	1374							protein binding			lung(1)|central_nervous_system(1)|skin(1)	3						GGGCCCGCCCGGCTACCTCCT	0.567			NA											25	55					6.38683e-12	9.65233e-12	0.008361	1	0
CDCA4	55038	broad.mit.edu	37	14	105477708	105477708	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:105477708G>C	uc001yqa.2	-	2	655	c.559C>G	c.(559-561)CCC>GCC	p.P187A	CDCA4_uc001yqb.2_Missense_Mutation_p.P187A	NM_145701	NP_663747	Q9BXL8	CDCA4_HUMAN	cell division cycle associated 4	187						nucleus				ovary(1)	1		all_cancers(154;0.0798)|Melanoma(154;0.155)|all_epithelial(191;0.183)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.142)		TCGTAGTAGGGGCTGTCCACG	0.582			NA											6	63					0	0	0.001168	0	0
CDCA4	55038	broad.mit.edu	37	14	105477746	105477746	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:105477746G>C	uc001yqa.2	-	2	617	c.521C>G	c.(520-522)CCC>CGC	p.P174R	CDCA4_uc001yqb.2_Missense_Mutation_p.P174R	NM_145701	NP_663747	Q9BXL8	CDCA4_HUMAN	cell division cycle associated 4	174						nucleus				ovary(1)	1		all_cancers(154;0.0798)|Melanoma(154;0.155)|all_epithelial(191;0.183)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.142)		CATGCAGCTGGGGTTTTTAGT	0.562			NA											4	65					0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	15	22440647	22440647	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:22440647C>T	uc001yug.2	-	1	219	c.200G>A	c.(199-201)TGG>TAG	p.W67*						full-length cDNA clone CS0DI014YE21 of Placenta Cot 25-normalized of Homo sapiens (human).												NA						TTCTGAGCCCCAGGAGAAATT	0.517			NA											6	17					0	0	0.001168	0	0
SLC12A6	9990	broad.mit.edu	37	15	34536239	34536239	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:34536239C>A	uc001zhw.2	-	15	2142	c.1978G>T	c.(1978-1980)GCA>TCA	p.A660S	SLC12A6_uc001zhv.2_Missense_Mutation_p.A609S|SLC12A6_uc001zhx.2_Missense_Mutation_p.A645S|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Missense_Mutation_p.A601S|SLC12A6_uc001zib.2_Missense_Mutation_p.A651S|SLC12A6_uc001zic.2_Missense_Mutation_p.A660S|SLC12A6_uc010bau.2_Missense_Mutation_p.A660S|SLC12A6_uc001zid.2_Missense_Mutation_p.A601S|SLC12A6_uc001zht.2_RNA|SLC12A6_uc001zhu.2_Missense_Mutation_p.A472S	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	660	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	AAGGCACATGCCAAGTTTACA	0.378			NA											32	73					4.11147e-13	6.38917e-13	0.003755	1	0
LTK	4058	broad.mit.edu	37	15	41797642	41797642	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:41797642C>G	uc001zoa.3	-	14	1962	c.1784G>C	c.(1783-1785)GGA>GCA	p.G595A	LTK_uc001zob.3_Missense_Mutation_p.G534A|LTK_uc010ucx.1_Missense_Mutation_p.G465A|LTK_uc010bcg.2_Missense_Mutation_p.G293A	NM_002344	NP_002335	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase isoform 1	595	Protein kinase.|Cytoplasmic (Potential).				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|central_nervous_system(1)	7		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		CATGTCCCCTCCAGACATCAG	0.597			NA								TSP Lung(18;0.14)			8	26					0	0	0.004482	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42436333	42436333	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:42436333G>T	uc001zoz.2	-	18	2048	c.1985C>A	c.(1984-1986)CCG>CAG	p.P662Q	PLA2G4F_uc010bcq.2_Intron|PLA2G4F_uc001zoy.2_Missense_Mutation_p.P294Q|PLA2G4F_uc010bcr.2_Missense_Mutation_p.P413Q|PLA2G4F_uc001zpa.2_Missense_Mutation_p.P413Q|PLA2G4F_uc010bcs.2_Missense_Mutation_p.P449Q	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	662	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		GAAGGCGTCCGGGTGTGTGTC	0.572			NA											11	54					0.000673444	0.000753709	0.008291	1	0
SEMA6D	80031	broad.mit.edu	37	15	48062872	48062872	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:48062872C>A	uc010bek.2	+	19	2472	c.2112C>A	c.(2110-2112)GCC>GCA	p.A704A	SEMA6D_uc001zvw.2_Silent_p.A642A|SEMA6D_uc001zvy.2_Silent_p.A704A|SEMA6D_uc001zvz.2_Silent_p.A648A|SEMA6D_uc001zwa.2_3'UTR|SEMA6D_uc001zwb.2_Silent_p.A642A|SEMA6D_uc001zwc.2_Silent_p.A629A	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	704	Cytoplasmic (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		CAGAGTCCGCCCAGTCATGCA	0.438			NA											27	69					7.26314e-15	1.17739e-14	0.007291	1	0
SECISBP2L	9728	broad.mit.edu	37	15	49284854	49284854	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:49284854C>T	uc001zxe.1	-	18	3027	c.2893G>A	c.(2893-2895)GAT>AAT	p.D965N	SECISBP2L_uc001zxd.1_Missense_Mutation_p.D920N	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	965										breast(1)|skin(1)	2						CAACTGCCATCCAAAGAGCCA	0.433			NA											42	51					0	0	0.006999	0	0
DTWD1	56986	broad.mit.edu	37	15	49935624	49935624	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:49935624A>T	uc001zxq.2	+	6	1041	c.764A>T	c.(763-765)TAC>TTC	p.Y255F	DTWD1_uc001zxs.2_Missense_Mutation_p.Y255F|DTWD1_uc001zxr.2_Missense_Mutation_p.Y168F|DTWD1_uc001zxo.2_Missense_Mutation_p.Y255F	NM_020234	NP_064619	Q8N5C7	DTWD1_HUMAN	DTW domain containing 1	255											0		all_lung(180;0.0384)		all cancers(107;3.27e-08)|GBM - Glioblastoma multiforme(94;7.6e-05)		GAAGCCATTTACTACTTTCTG	0.328			NA											25	58					0	0	0.00632	0	0
HDC	3067	broad.mit.edu	37	15	50534698	50534698	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:50534698C>A	uc001zxz.2	-	12	1854	c.1748G>T	c.(1747-1749)CGC>CTC	p.R583L	HDC_uc001zxy.2_Missense_Mutation_p.R326L|HDC_uc010uff.1_Missense_Mutation_p.R550L	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	583					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	ACTGAGGGAGCGCACCGTCTT	0.542	GBM(95;1627 1936 6910 9570)		NA											67	173					2.84776e-26	5.14735e-26	0.00361	1	0
FAM81A	145773	broad.mit.edu	37	15	59752207	59752207	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:59752207G>T	uc002agc.2	+	3	283	c.96G>T	c.(94-96)CAG>CAT	p.Q32H	FAM81A_uc010uha.1_Missense_Mutation_p.Q32H	NM_152450	NP_689663	Q8TBF8	FA81A_HUMAN	hypothetical protein LOC145773	32										ovary(1)	1						TCGTGGAGCAGCTGGAAGACA	0.542			NA											10	14					1.11149e-13	1.74841e-13	0.008291	1	0
VPS13C	54832	broad.mit.edu	37	15	62325678	62325678	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:62325678G>A	uc002agz.2	-	5	421	c.347C>T	c.(346-348)TCC>TTC	p.S116F	VPS13C_uc002aha.2_Missense_Mutation_p.S116F|VPS13C_uc002ahb.1_Missense_Mutation_p.S116F|VPS13C_uc002ahc.1_Missense_Mutation_p.S116F	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	116					protein localization					ovary(2)	2						TTCAATTCGGGATAGCTCTTT	0.289			NA											3	21					0	0	0.009096	0	0
TPM1	7168	broad.mit.edu	37	15	63363340	63363340	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:63363340A>T	uc002alm.2	+	10	1141	c.950A>T	c.(949-951)GAT>GTT	p.D317V	TPM1_uc010bgn.2_RNA|TPM1_uc002ali.2_Missense_Mutation_p.D275V|TPM1_uc002alj.2_Missense_Mutation_p.D275V|TPM1_uc002alk.2_Missense_Mutation_p.D275V|TPM1_uc002all.2_Missense_Mutation_p.D275V|TPM1_uc010uig.1_Missense_Mutation_p.D239V|TPM1_uc002alt.2_Missense_Mutation_p.D239V|TPM1_uc010bgp.2_Missense_Mutation_p.D149V	NM_001018008	NP_001018008	P09493	TPM1_HUMAN	tropomyosin 1 alpha chain isoform 6	275	By similarity.				cardiac muscle contraction|cellular component movement|cellular response to reactive oxygen species|muscle filament sliding|negative regulation of cell migration|positive regulation of ATPase activity|positive regulation of cell adhesion|positive regulation of heart rate by epinephrine|positive regulation of stress fiber assembly|regulation of muscle contraction|ruffle organization|sarcomere organization|ventricular cardiac muscle tissue morphogenesis|wound healing	bleb|cytosol|muscle thin filament tropomyosin|ruffle membrane|stress fiber	actin binding|structural constituent of cytoskeleton|structural constituent of muscle				0						CAGATGCTGGATCAGACTTTA	0.368			NA											22	59					0	0	0.00278	0	0
C15orf44	81556	broad.mit.edu	37	15	65888105	65888105	+	Silent	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:65888105G>C	uc002apd.2	-	7	1143	c.807C>G	c.(805-807)TCC>TCG	p.S269S	C15orf44_uc010uix.1_Silent_p.S305S|C15orf44_uc010uiz.1_Silent_p.S233S|C15orf44_uc010uja.1_Silent_p.S220S|C15orf44_uc010ujb.1_Silent_p.S190S|C15orf44_uc002ape.3_Silent_p.S269S|C15orf44_uc010uiy.1_Silent_p.S190S	NM_030800	NP_110427	Q96SY0	CO044_HUMAN	hypothetical protein LOC81556 isoform 2	269										ovary(1)	1						CCAGATGTCTGGACAGAACTG	0.353			NA											12	35					0	0	0.00245	0	0
SMAD3	4088	broad.mit.edu	37	15	67473677	67473677	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:67473677C>T	uc002aqj.2	+	6	1055	c.757C>T	c.(757-759)CCA>TCA	p.P253S	SMAD3_uc010ujr.1_Missense_Mutation_p.P148S|SMAD3_uc010ujs.1_Missense_Mutation_p.P209S|SMAD3_uc010ujt.1_Missense_Mutation_p.P58S	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	253	MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		CGCCTCGCAGCCATCCATGAC	0.597			NA											4	37					0	0	0.009096	0	0
LARP6	55323	broad.mit.edu	37	15	71124586	71124586	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:71124586G>T	uc002ass.2	-	3	1352	c.1281C>A	c.(1279-1281)CCC>CCA	p.P427P		NM_018357	NP_060827	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	427					RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0						GGCTGCCAGAGGGAGTGACGC	0.612			NA											20	66					3.51602e-12	5.35046e-12	0.008871	1	0
SGK269	79834	broad.mit.edu	37	15	77471194	77471194	+	Silent	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:77471194T>C	uc002bcm.2	-	3	3383	c.3075A>G	c.(3073-3075)CTA>CTG	p.L1025L	SGK269_uc002bcn.2_Silent_p.L1025L	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	1025					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		CTGAGTCCTGTAGTAATGCAT	0.458			NA											10	54					0	0	0.006214	0	0
ALPK3	57538	broad.mit.edu	37	15	85360091	85360091	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:85360091G>T	uc002ble.2	+	1	181	c.14G>T	c.(13-15)TGG>TTG	p.W5L		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	5					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			gaggTGGCTTGGCTTGTCTAT	0.333			NA											7	15					2.0095e-06	2.51391e-06	0.001984	1	0
Unknown	0	broad.mit.edu	37	15	85787980	85787980	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:85787980T>G	uc010upj.1	+	6	788	c.723T>G	c.(721-723)CAT>CAG	p.H241Q	uc010upk.1_5'Flank	NM_198181	NP_937824			golgi autoantigen, golgin subfamily a, 6D-like												NA						TACGTGAACATGAGGAGAGGC	0.562			NA											2	7					0	0	0.004672	0	0
AGBL1	123624	broad.mit.edu	37	15	87089343	87089343	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:87089343C>A	uc002blz.1	+	19	2738	c.2658C>A	c.(2656-2658)ATC>ATA	p.I886I		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	886					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						CATCTACTATCCTAGAGGAGG	0.473			NA											13	29					0.000219431	0.000251245	0.00245	1	0
KIF7	374654	broad.mit.edu	37	15	90172699	90172699	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:90172699G>T	uc002bof.2	-	17	3501	c.3424C>A	c.(3424-3426)CTG>ATG	p.L1142M	KIF7_uc010upw.1_Missense_Mutation_p.L628M|C15orf42_uc010upv.1_RNA	NM_198525	NP_940927	Q2M1P5	KIF7_HUMAN	kinesin family member 7	1142	Potential.				microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			ovary(2)|lung(1)	3	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			TGCCGCTCCAGGGCCACCTCC	0.637			NA											15	38					8.60227e-14	1.35455e-13	0.004007	1	0
CRTC3	64784	broad.mit.edu	37	15	91172586	91172586	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr15:91172586C>T	uc002bpp.2	+	11	1194	c.1088C>T	c.(1087-1089)TCG>TTG	p.S363L	CRTC3_uc002bpo.2_Missense_Mutation_p.S363L	NM_022769	NP_073606	Q6UUV7	CRTC3_HUMAN	transducer of regulated CREB protein 3 isoform	363					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	salivary_gland(26)|ovary(1)	27	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			CTTCACCCTTCGCTCCGTCTG	0.552			NA	T	MAML2	salivary gland mucoepidermoid								21	285					0	0	0.002299	0	0
PKD1	5310	broad.mit.edu	37	16	2160773	2160773	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:2160773G>A	uc002cos.1	-	15	4604	c.4395C>T	c.(4393-4395)CCC>CCT	p.P1465P	PKD1_uc002cot.1_Silent_p.P1465P	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	1465	Extracellular (Potential).|PKD 9.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						TGACCAGCACGGGCTCCTGCA	0.622			NA											7	82					0	0	0.00308	0	0
C16orf59	80178	broad.mit.edu	37	16	2511049	2511049	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:2511049C>A	uc002cqh.2	+	4	460	c.429C>A	c.(427-429)CGC>CGA	p.R143R	C16orf59_uc002cqf.1_Silent_p.R143R|C16orf59_uc002cqg.1_5'UTR|C16orf59_uc002cqi.2_5'UTR|C16orf59_uc010uwb.1_5'UTR	NM_025108	NP_079384	Q7L2K0	CP059_HUMAN	hypothetical protein LOC80178	143											0		Ovarian(90;0.17)				AGGGCCTCCGCCAGACCACGG	0.687			NA											9	54					2.27111e-07	2.94651e-07	0.001368	1	0
GRIN2A	2903	broad.mit.edu	37	16	9934562	9934562	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:9934562C>A	uc002czo.3	-	7	2141	c.1593G>T	c.(1591-1593)ACG>ACT	p.T531T	GRIN2A_uc010uym.1_Silent_p.T531T|GRIN2A_uc010uyn.1_Silent_p.T374T|GRIN2A_uc002czr.3_Silent_p.T531T	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	531	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CACTGATTCCCGTTTCCACAA	0.468			NA											8	54					0.000274275	0.000311722	0.004482	1	0
GRIN2A	2903	broad.mit.edu	37	16	9943758	9943758	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:9943758A>T	uc002czo.3	-	5	1731	c.1183T>A	c.(1183-1185)TCC>ACC	p.S395T	GRIN2A_uc010uym.1_Missense_Mutation_p.S395T|GRIN2A_uc010uyn.1_Missense_Mutation_p.S238T|GRIN2A_uc002czr.3_Missense_Mutation_p.S395T	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	395	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCGGAGAAGGACTTGTACCTG	0.582			NA											6	74					0	0	0.001984	0	0
CPPED1	55313	broad.mit.edu	37	16	12875245	12875245	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:12875245C>A	uc002dca.3	-	2	197	c.86G>T	c.(85-87)TGG>TTG	p.W29L	CPPED1_uc002dcb.3_Missense_Mutation_p.W29L	NM_018340	NP_060810	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain	29							hydrolase activity|metal ion binding				0						TGGGCCTTTCCATTCGCTTTC	0.473			NA											6	37					0.00116845	0.0012964	0.001168	1	0
PDXDC1	23042	broad.mit.edu	37	16	15111246	15111246	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:15111246G>T	uc002dda.3	+	11	1154	c.930G>T	c.(928-930)GCG>GCT	p.A310A	PDXDC1_uc010uzl.1_Silent_p.A295A|PDXDC1_uc010uzm.1_Silent_p.A219A|PDXDC1_uc002dcz.2_Silent_p.A287A|PDXDC1_uc002ddb.3_Silent_p.A283A|PDXDC1_uc010uzn.1_Silent_p.A282A|PDXDC1_uc002ddc.2_Silent_p.A310A	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain	310					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	CTGTTCCTGCGGTGACACTGT	0.498			NA											12	162					0.000422831	0.000478794	0.004007	1	0
ABCC1	4363	broad.mit.edu	37	16	16162136	16162136	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:16162136A>G	uc010bvi.2	+	13	1976	c.1801A>G	c.(1801-1803)ATG>GTG	p.M601V	ABCC1_uc010bvj.2_Missense_Mutation_p.M601V|ABCC1_uc010bvk.2_Missense_Mutation_p.M601V|ABCC1_uc010bvl.2_Missense_Mutation_p.M601V|ABCC1_uc010bvm.2_Missense_Mutation_p.M601V|ABCC1_uc002del.3_Missense_Mutation_p.M485V	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	601	ABC transmembrane type-1 1.|Helical; Name=11.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CATTCTCCCCATGGTCATCAG	0.577			NA											10	130					0	0	0.001368	0	0
CP110	9738	broad.mit.edu	37	16	19548650	19548650	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:19548650A>T	uc002dgl.3	+	4	1906	c.1659A>T	c.(1657-1659)TTA>TTT	p.L553F	CP110_uc002dgk.3_Missense_Mutation_p.L553F			O43303	CP110_HUMAN	RecName: Full=Centrosomal protein of 110 kDa;          Short=Cep110;	553	Interaction with CEP76.				centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding				0						CTTCTCCTTTATTGATGCAAA	0.388			NA											19	52					0	0	0.002299	0	0
GPR139	124274	broad.mit.edu	37	16	20043588	20043588	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:20043588G>T	uc002dgu.1	-	2	693	c.531C>A	c.(529-531)ACC>ACA	p.T177T	GPR139_uc010vaw.1_Silent_p.T84T	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	177	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(2)	2						GATGCACAGAGGTGCTGATGT	0.498			NA											19	61					1.45105e-14	2.33503e-14	0.006122	1	0
ACSM2A	123876	broad.mit.edu	37	16	20491921	20491921	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:20491921C>A	uc010bwe.2	+	12	1547	c.1308C>A	c.(1306-1308)AAC>AAA	p.N436K	ACSM2A_uc010vax.1_Missense_Mutation_p.N357K|ACSM2A_uc002dhf.3_Missense_Mutation_p.N436K|ACSM2A_uc002dhg.3_Missense_Mutation_p.N436K|ACSM2A_uc010vay.1_Missense_Mutation_p.N357K|ACSM2A_uc002dhh.3_Missense_Mutation_p.N66K	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	436					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CAGCAGCCAACATTCGAGGAG	0.502			NA											6	168					0.000157383	0.000180738	0.00308	1	0
ACSM2B	348158	broad.mit.edu	37	16	20554314	20554314	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:20554314C>A	uc002dhj.3	-	13	1641	c.1431G>T	c.(1429-1431)GAG>GAT	p.E477D	ACSM2B_uc002dhk.3_Missense_Mutation_p.E477D|ACSM2B_uc010bwf.1_Missense_Mutation_p.E477D	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	477					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						CATTCTCTACCTCCGAGGGTC	0.577			NA											14	82					1.05317e-09	1.50035e-09	0.00245	1	0
DNAH3	55567	broad.mit.edu	37	16	21073886	21073886	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:21073886C>T	uc010vbe.1	-	25	3637	c.3637G>A	c.(3637-3639)GAC>AAC	p.D1213N		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1213	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TCCAGATTGTCTGTAAACTCA	0.463			NA											14	100					0	0	0.006122	0	0
VWA3A	146177	broad.mit.edu	37	16	22152985	22152985	+	Silent	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:22152985G>C	uc010vbq.1	+	24	2562	c.2466G>C	c.(2464-2466)CTG>CTC	p.L822L	VWA3A_uc010bxd.2_RNA|VWA3A_uc002dkg.3_5'Flank	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	822						extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		CTCTTTTACTGTTCTACACAG	0.537			NA											5	18					0	0	0.000602	0	0
IL4R	3566	broad.mit.edu	37	16	27374420	27374420	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:27374420G>A	uc002don.2	+	11	1989	c.1747G>A	c.(1747-1749)GAG>AAG	p.E583K	IL4R_uc002dop.3_Missense_Mutation_p.E568K|IL4R_uc010bxy.2_Missense_Mutation_p.E583K|IL4R_uc002doo.2_Missense_Mutation_p.E423K	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	583	Required for IL4-induced gene expression.|Cytoplasmic (Potential).				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						ACATGCGGTGGAGCAGGGTGG	0.647			NA											11	45					0	0	0.000978	0	0
ATP2A1	487	broad.mit.edu	37	16	28905841	28905841	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:28905841G>T	uc002dro.1	+	11	1384	c.1200G>T	c.(1198-1200)AAG>AAT	p.K400N	uc010vct.1_Intron|ATP2A1_uc002drn.1_Missense_Mutation_p.K400N|ATP2A1_uc002drp.1_Missense_Mutation_p.K275N	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	400	Interacts with phospholamban 1 (By similarity).|Cytoplasmic (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AGAATGATAAGCCAGTCCGGC	0.572			NA											8	30					5.18039e-06	6.37205e-06	0.00308	1	0
SEPT1	1731	broad.mit.edu	37	16	30392511	30392511	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:30392511G>T	uc002dxy.2	-	7	682	c.495C>A	c.(493-495)ATC>ATA	p.I165I	SEPT1_uc002dxw.2_5'Flank|SEPT1_uc002dxx.2_5'UTR|SEPT1_uc010veq.1_3'UTR	NM_052838	NP_443070	Q8WYJ6	SEPT1_HUMAN	septin 1	165					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			ovary(1)	1			Colorectal(24;0.193)			TGACTGGGATGATGTTGACTT	0.587			NA											20	130					1.96292e-10	2.8626e-10	0.010504	1	0
ITGAL	3683	broad.mit.edu	37	16	30495236	30495236	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:30495236G>A	uc002dyi.3	+	8	987	c.811G>A	c.(811-813)GGC>AGC	p.G271S	ITGAL_uc010veu.1_RNA|ITGAL_uc002dyj.3_Missense_Mutation_p.G188S|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	271	VWFA.|Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	CACTGACAGTGGCAACATCGA	0.582	NSCLC(110;1462 1641 3311 33990 49495)		NA											29	161					0	0	0.002096	0	0
SRCAP	10847	broad.mit.edu	37	16	30723384	30723384	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:30723384G>T	uc002dze.1	+	12	2106	c.1721G>T	c.(1720-1722)GGG>GTG	p.G574V	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.G431V|SRCAP_uc010bzz.1_Missense_Mutation_p.G144V	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	574					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CCTACTCCAGGGCCCACTACT	0.537			NA											19	59					1.01871e-10	1.49983e-10	0.008871	1	0
SRCAP	10847	broad.mit.edu	37	16	30748500	30748501	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:30748500_30748501GG>TT	uc002dze.1	+	34	7524_7525	c.7139_7140GG>TT	c.(7138-7140)CGG>CTT	p.R2380L	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.R2175L	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2380					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			GGCACCCACCGGCGCAGTAAAA	0.649			NA											5	21					0	0	0.004672	0	0
STX4	6810	broad.mit.edu	37	16	31046343	31046343	+	Silent	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:31046343A>C	uc002eal.2	+	5	584	c.360A>C	c.(358-360)ACA>ACC	p.T120T	STX4_uc002eak.2_Silent_p.T118T|STX4_uc002eam.2_Silent_p.T42T	NM_004604	NP_004595	Q12846	STX4_HUMAN	syntaxin 4	120	Cytoplasmic (Potential).|Potential.				intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity				0						CCGTCAACACAAGAATGAGAA	0.408			NA											8	98					0	0	0.00308	0	0
TGFB1I1	7041	broad.mit.edu	37	16	31485036	31485036	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:31485036G>A	uc002ecd.1	+	3	189	c.163G>A	c.(163-165)GAC>AAC	p.D55N	TGFB1I1_uc002ece.1_Missense_Mutation_p.D38N|TGFB1I1_uc010caq.1_5'UTR	NM_001042454	NP_001035919	O43294	TGFI1_HUMAN	transforming growth factor beta 1 induced	55	Transcription activation (By similarity).|Interaction with PTK2B.				androgen receptor signaling pathway|cell adhesion|negative regulation of cell proliferation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|transcription from RNA polymerase II promoter|ubiquitin-dependent SMAD protein catabolic process|Wnt receptor signaling pathway	cytoplasm|cytoskeleton|focal adhesion|nuclear matrix	androgen receptor binding|I-SMAD binding|Roundabout binding|transcription coactivator activity|zinc ion binding				0						AGCCTCGGGGGACAAGGACCA	0.637			NA											8	103					0	0	0.00308	0	0
NETO2	81831	broad.mit.edu	37	16	47117419	47117419	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:47117419C>T	uc002eer.1	-	9	1676	c.1291G>A	c.(1291-1293)GCC>ACC	p.A431T	NETO2_uc002eeq.1_Missense_Mutation_p.A166T|NETO2_uc010vgf.1_Missense_Mutation_p.A288T	NM_018092	NP_060562	Q8NC67	NETO2_HUMAN	neuropilin- and tolloid-like protein 2	431	Cytoplasmic (Potential).					integral to membrane	receptor activity				0		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				CAGCGGGAGGCGGTGGAGGAG	0.527			NA								HNSCC(25;0.065)			27	98					0	0	0.00632	0	0
ABCC12	94160	broad.mit.edu	37	16	48117856	48117856	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:48117856G>T	uc002efc.1	-	28	4303	c.3957C>A	c.(3955-3957)CTC>CTA	p.L1319L	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	1319	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				GATCGCAGTTGAGAACTGTGT	0.512			NA											31	105					7.72975e-29	1.4205e-28	0.002836	1	0
N4BP1	9683	broad.mit.edu	37	16	48576960	48576960	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:48576960C>A	uc002efp.2	-	7	2783	c.2546G>T	c.(2545-2547)AGA>ATA	p.R849I		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	849					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)				TGCAGAAGATCTCTGAGCTGG	0.582			NA											7	56					8.12818e-05	9.43997e-05	0.001984	1	0
C16orf78	123970	broad.mit.edu	37	16	49407973	49407973	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:49407973G>T	uc002efr.2	+	1	166	c.123G>T	c.(121-123)AGG>AGT	p.R41S		NM_144602	NP_653203	Q8WTQ4	CP078_HUMAN	hypothetical protein LOC123970	41										central_nervous_system(1)	1						TGGAGCGGAGGCAGGGGAAGA	0.383			NA											15	82					4.14922e-12	6.29536e-12	0.004007	1	0
ADCY7	113	broad.mit.edu	37	16	50338319	50338319	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:50338319G>C	uc002egd.1	+	10	1685	c.1417G>C	c.(1417-1419)GAC>CAC	p.D473H	ADCY7_uc002egb.1_Missense_Mutation_p.D473H|ADCY7_uc002egc.1_Missense_Mutation_p.D473H	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	473	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	GCCCAAGGGGGACGCGGCCCT	0.697			NA											4	29					0	0	0.009096	0	0
SLC12A3	6559	broad.mit.edu	37	16	56936384	56936384	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:56936384G>C	uc010ccm.2	+	24	2849	c.2820G>C	c.(2818-2820)AAG>AAC	p.K940N	SLC12A3_uc002ekd.3_Missense_Mutation_p.K949N|SLC12A3_uc010ccn.2_Missense_Mutation_p.K948N	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	940	Cytoplasmic (Potential).				sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	GCCCCTGGAAGATCTCAGATG	0.562			NA											15	44					0	0	0.003163	0	0
COQ9	57017	broad.mit.edu	37	16	57486813	57486813	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:57486813G>T	uc002elq.2	+	3	359	c.343G>T	c.(343-345)GGG>TGG	p.G115W	COQ9_uc002elp.1_Missense_Mutation_p.G115W|COQ9_uc010vhn.1_Missense_Mutation_p.G115W|COQ9_uc010vho.1_Missense_Mutation_p.G115W|COQ9_uc010vhp.1_Missense_Mutation_p.G115W|COQ9_uc002elr.2_Missense_Mutation_p.G115W	NM_020312	NP_064708	O75208	COQ9_HUMAN	coenzyme Q9 homolog precursor	115					ubiquinone biosynthetic process	mitochondrion				breast(1)	1						GCCCGCCCACGGGTGGACAGC	0.602			NA											19	69					1.01871e-10	1.49983e-10	0.008871	1	0
GPR97	222487	broad.mit.edu	37	16	57712138	57712138	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:57712138C>A	uc002emh.2	+	4	505	c.402C>A	c.(400-402)CCC>CCA	p.P134P	GPR97_uc010cdc.2_Silent_p.P134P|GPR97_uc010vhv.1_Silent_p.P14P|GPR97_uc010cdd.2_RNA|GPR97_uc010cde.2_5'Flank	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97 precursor	134	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1						TGCGACTTCCCAAGAGCCTTT	0.582			NA											13	65					9.31168e-06	1.1336e-05	0.001855	1	0
CDH11	1009	broad.mit.edu	37	16	64984694	64984694	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:64984694G>T	uc002eoi.2	-	12	2304	c.1870C>A	c.(1870-1872)CTC>ATC	p.L624I	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Missense_Mutation_p.L624I|CDH11_uc010vin.1_Missense_Mutation_p.L498I	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	624	Helical; (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		ATGCAGGCGAGGATGGCGATC	0.617			NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			5	37					5.9392e-07	7.59035e-07	0.001168	1	0
CES2	8824	broad.mit.edu	37	16	66975441	66975441	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:66975441G>T	uc002eqr.2	+	7	2140	c.1140G>T	c.(1138-1140)GGG>GGT	p.G380G	CES2_uc002eqq.2_Silent_p.G380G|CES2_uc002eqs.2_Silent_p.G223G	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	316					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		TGGTGGATGGGGTCTTCCTGC	0.567	Ovarian(70;1230 1691 37888 38351)		NA											8	52					0.000274275	0.000311722	0.004482	1	0
NFATC3	4775	broad.mit.edu	37	16	68156594	68156594	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:68156594C>T	uc002evo.1	+	2	1018	c.808C>T	c.(808-810)CCC>TCC	p.P270S	NFATC3_uc010vkl.1_5'UTR|NFATC3_uc010vkm.1_5'UTR|NFATC3_uc010vkn.1_5'UTR|NFATC3_uc010vko.1_5'UTR|NFATC3_uc010vkp.1_5'UTR|NFATC3_uc010vkq.1_5'UTR|NFATC3_uc002evl.2_Intron|NFATC3_uc002evk.2_Missense_Mutation_p.P270S|NFATC3_uc002evm.1_Missense_Mutation_p.P270S|NFATC3_uc002evn.1_Missense_Mutation_p.P270S|NFATC3_uc010vkr.1_5'UTR|NFATC3_uc010vks.1_5'UTR|NFATC3_uc010vkt.1_5'UTR|NFATC3_uc010vku.1_5'UTR|NFATC3_uc010vkv.1_5'UTR|NFATC3_uc010vkw.1_5'UTR|NFATC3_uc010vkx.1_5'UTR|NFATC3_uc010vky.1_5'UTR|NFATC3_uc010vkz.1_5'UTR|NFATC3_uc010vla.1_5'UTR|NFATC3_uc010vlb.1_5'UTR|NFATC3_uc010vlc.1_5'UTR	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	270	3 X SP repeats.				inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		GCCCACATCCCCCTGTGGGAA	0.582			NA											12	69					0	0	0.000978	0	0
ZFP90	146198	broad.mit.edu	37	16	68597462	68597462	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:68597462G>T	uc010cff.2	+	5	1064	c.772G>T	c.(772-774)GAC>TAC	p.D258Y	ZFP90_uc002ewb.2_Silent_p.P63P|ZFP90_uc002ewc.2_Silent_p.P63P|ZFP90_uc002ewd.2_Missense_Mutation_p.D258Y|ZFP90_uc002ewe.2_Missense_Mutation_p.D258Y	NM_133458	NP_597715	Q8TF47	ZFP90_HUMAN	zinc finger protein 90	258	C2H2-type 2.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		TGAATGTACCGACTGTGGGAA	0.423			NA											26	139					3.99451e-17	6.70103e-17	0.009535	1	0
AP1G1	164	broad.mit.edu	37	16	71779116	71779116	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:71779116C>T	uc010cgg.2	-	19	2244	c.1930G>A	c.(1930-1932)GCG>ACG	p.A644T	AP1G1_uc002fba.2_Missense_Mutation_p.A647T|AP1G1_uc002fbb.2_Missense_Mutation_p.A667T|AP1G1_uc002faz.2_Missense_Mutation_p.A61T	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	644					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				CTTGTAGGCGCAGTTGGAATA	0.408			NA											18	84					0	0	0.006122	0	0
KIAA0174	9798	broad.mit.edu	37	16	71961559	71961559	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:71961559G>T	uc002fbj.1	+	12	1266	c.983G>T	c.(982-984)AGA>ATA	p.R328I	KIAA0174_uc010cgh.1_Missense_Mutation_p.R328I|KIAA0174_uc002fbk.1_Missense_Mutation_p.D314Y|KIAA0174_uc002fbm.1_Missense_Mutation_p.R315I|KIAA0174_uc002fbl.1_Missense_Mutation_p.R284I|KIAA0174_uc002fbn.1_Missense_Mutation_p.R167I|KIAA0174_uc010cgi.1_Missense_Mutation_p.R86I|KIAA0174_uc010cgj.1_Missense_Mutation_p.R232I|KIAA0174_uc010vml.1_RNA			P53990	IST1_HUMAN	SubName: Full=cDNA FLJ32696 fis, clone TESTI2000358; SubName: Full=cDNA FLJ77725;	313	Interaction with VTA1.				cell cycle|cell division	cytoplasmic membrane-bounded vesicle|ER-Golgi intermediate compartment	protein binding			ovary(1)	1						CTTCCTTCCAGACCTGCAGAT	0.498			NA											41	206					7.62715e-32	1.42719e-31	0.007835	1	0
CNTNAP4	85445	broad.mit.edu	37	16	76350378	76350378	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:76350378A>T	uc002feu.1	+	4	539	c.154A>T	c.(154-156)AGC>TGC	p.S52C	CNTNAP4_uc002fev.1_5'UTR|CNTNAP4_uc010chb.1_Missense_Mutation_p.S27C|CNTNAP4_uc002fex.1_Missense_Mutation_p.S55C|CNTNAP4_uc002few.2_Missense_Mutation_p.S27C	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	52	Extracellular (Potential).|F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						CGAGCTCTCCAGCAGTCATGG	0.473			NA											6	34					0	0	0.001984	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76482812	76482812	+	Silent	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:76482812A>G	uc002feu.1	+	8	1276	c.891A>G	c.(889-891)GCA>GCG	p.A297A	CNTNAP4_uc002fev.1_Silent_p.A209A|CNTNAP4_uc010chb.1_Silent_p.A272A|CNTNAP4_uc002fex.1_Silent_p.A300A|CNTNAP4_uc002few.2_Silent_p.A272A	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	297	Extracellular (Potential).|Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						ATTTCCATGCACGGGGAGAAT	0.418			NA											5	31					0	0	0.001168	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76569506	76569506	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:76569506G>T	uc002feu.1	+	20	3205	c.2820G>T	c.(2818-2820)ATG>ATT	p.M940I	CNTNAP4_uc002fev.1_Missense_Mutation_p.M804I|CNTNAP4_uc010chb.1_Missense_Mutation_p.M867I|CNTNAP4_uc002fex.1_Missense_Mutation_p.M943I	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	940	Extracellular (Potential).|Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TGAATGGGATGACCCTGGATT	0.517			NA											12	74					9.31168e-06	1.1336e-05	0.001855	1	0
CLEC3A	10143	broad.mit.edu	37	16	78064691	78064691	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:78064691T>C	uc002ffh.3	+	3	628	c.547T>C	c.(547-549)TGT>CGT	p.C183R		NM_005752	NP_005743	O75596	CLC3A_HUMAN	C-type lectin domain family 3 member A	183	C-type lectin.				skeletal system development	extracellular region	sugar binding				0						TGATGAGGCCTGTCGCAGCAG	0.498			NA											11	77					0	0	0.001855	0	0
DYNLRB2	83657	broad.mit.edu	37	16	80583453	80583453	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:80583453T>C	uc002ffo.2	+	5	272	c.152T>C	c.(151-153)ATG>ACG	p.M51T	DYNLRB2_uc002ffp.2_RNA|DYNLRB2_uc002ffq.2_RNA	NM_130897	NP_570967	Q8TF09	DLRB2_HUMAN	dynein, light chain, roadblock-type 2	51					microtubule-based movement|transport	cytoplasmic dynein complex|microtubule	microtubule motor activity				0						CACCTGACAATGAAAGCCAAA	0.378			NA											4	44					0	0	0.000602	0	0
C16orf46	123775	broad.mit.edu	37	16	81097426	81097426	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:81097426G>A	uc002fgc.3	-	3	394	c.135C>T	c.(133-135)CTC>CTT	p.L45L	C16orf46_uc010chf.2_Silent_p.L45L|C16orf46_uc010vno.1_Intron	NM_152337	NP_689550	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46 isoform 2	45											0						CACTGACATCGAGAAGACAAT	0.358			NA											21	107					0	0	0.002299	0	0
SLC38A8	146167	broad.mit.edu	37	16	84070307	84070307	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:84070307G>T	uc002fhg.1	-	2	388	c.388C>A	c.(388-390)CTG>ATG	p.L130M		NM_001080442	NP_001073911	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	130					amino acid transport|sodium ion transport	integral to membrane					0						AGGTACTTACGCTTCTCCAGC	0.622			NA											5	30					1.23904e-05	1.49305e-05	0.000602	1	0
KIAA0513	9764	broad.mit.edu	37	16	85109450	85109450	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:85109450G>T	uc002fiu.2	+	5	724	c.504G>T	c.(502-504)GAG>GAT	p.E168D	KIAA0513_uc002fis.3_Missense_Mutation_p.E168D|KIAA0513_uc010voj.1_Missense_Mutation_p.E168D|KIAA0513_uc002fit.2_Missense_Mutation_p.E168D	NM_014732	NP_055547	O60268	K0513_HUMAN	hypothetical protein LOC9764	168						cytoplasm				breast(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.234)		CTTGTTTCAGGTGTCATCAGA	0.522			NA											11	58					1.08611e-07	1.42471e-07	0.000978	1	0
Unknown	0	broad.mit.edu	37	16	88620361	88620361	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:88620361G>A	uc010vox.1	-	2	269	c.269C>T	c.(268-270)CCC>CTC	p.P90L						RecName: Full=Putative uncharacterized protein C16orf85;												NA						TGCAGAGCTGGGACGGACGCC	0.652			NA											11	48					0	0	0.008291	0	0
Unknown	0	broad.mit.edu	37	16	90160912	90160912	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:90160912G>T	uc002fqp.2	+	2	863	c.385G>T	c.(385-387)GCT>TCT	p.A129S	uc002fqq.2_Intron					Homo sapiens, Similar to tubulin, beta, 2, clone IMAGE:4873024, mRNA.												NA						CCCTCCCCTCGCTCATGCCCT	0.736			NA											8	24					5.4927e-09	7.63426e-09	0.004482	1	0
PRPF8	10594	broad.mit.edu	37	17	1578503	1578503	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:1578503C>A	uc002fte.2	-	20	3117	c.3003G>T	c.(3001-3003)GTG>GTT	p.V1001V		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1001						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TGTTGTGGTCCACGATGAGGC	0.512			NA											14	38					3.27435e-08	4.40009e-08	0.00245	1	0
ZZEF1	23140	broad.mit.edu	37	17	4008083	4008083	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:4008083C>A	uc002fxe.2	-	8	1481	c.1417G>T	c.(1417-1419)GAA>TAA	p.E473*	ZZEF1_uc002fxk.1_Nonsense_Mutation_p.E473*	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	473							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AGAGTCAGTTCTACCTCTGGG	0.438			NA											9	55					0.00448238	0.00488872	0.004482	1	0
ENO3	2027	broad.mit.edu	37	17	4856127	4856127	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:4856127G>T	uc002gab.3	+	3	217	c.123G>T	c.(121-123)ACG>ACT	p.T41T	ENO3_uc010vsr.1_5'UTR|ENO3_uc002gac.3_Silent_p.T41T|ENO3_uc010vss.1_Silent_p.T41T|ENO3_uc010vst.1_5'Flank	NM_053013	NP_443739	P13929	ENOB_HUMAN	enolase 3	41					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex	magnesium ion binding|phosphopyruvate hydratase activity			ovary(1)	1						GGGCTTCCACGGGTATCTATG	0.502			NA											5	12					3.59834e-05	4.24306e-05	0.001168	1	0
TP53	7157	broad.mit.edu	37	17	7577096	7577096	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:7577096T>A	uc002gim.2	-	8	1036	c.842A>T	c.(841-843)GAC>GTC	p.D281V	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.D281V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.D149V|TP53_uc010cng.1_Missense_Mutation_p.D149V|TP53_uc002gii.1_Missense_Mutation_p.D149V|TP53_uc010cnh.1_Missense_Mutation_p.D281V|TP53_uc010cni.1_Missense_Mutation_p.D281V|TP53_uc002gij.2_Missense_Mutation_p.D281V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	281	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		D -> Y (in sporadic cancers; somatic mutation).|D -> E (in sporadic cancers; somatic mutation).|D -> V (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|D -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|D -> G (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|D -> A (in sporadic cancers; somatic mutation).|D -> N (in LFS; germline mutation and in sporadic cancers; somatic mutation).|D -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.D281E(25)|p.D281H(19)|p.D281N(18)|p.D281G(10)|p.0?(7)|p.D281Y(6)|p.D281D(5)|p.D281V(3)|p.D281fs*63(2)|p.?(2)|p.R280_D281delRD(2)|p.D281A(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.D281fs*24(1)|p.R280fs*62(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275fs*20(1)|p.D281R(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGTGCGCCGGTCTCTCCCAGG	0.552	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	29					0	0	0.008291	0	0
CHD3	1107	broad.mit.edu	37	17	7796813	7796813	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:7796813C>T	uc002gje.2	+	5	869	c.719C>T	c.(718-720)CCC>CTC	p.P240L	CHD3_uc002gjd.2_Missense_Mutation_p.P299L|CHD3_uc002gjf.2_Missense_Mutation_p.P240L|CHD3_uc002gjg.1_Missense_Mutation_p.P72L	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	240					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				TCCGGACCCCCCGCCCTTCCA	0.493			NA											15	18					0	0	0.00245	0	0
WDR16	146845	broad.mit.edu	37	17	9546502	9546502	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:9546502C>A	uc002gly.2	+	14	1919	c.1850C>A	c.(1849-1851)CCA>CAA	p.P617Q	USP43_uc002gma.3_5'Flank|USP43_uc010cod.2_5'Flank|USP43_uc010vva.1_5'Flank|WDR16_uc002glz.2_Missense_Mutation_p.P549Q|WDR16_uc010coc.2_Missense_Mutation_p.P627Q	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	617	WD 11.					cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						TGGAAGTACCCATATACCTCC	0.463			NA											22	79					3.01185e-09	4.22042e-09	0.003954	1	0
MYH4	4622	broad.mit.edu	37	17	10352302	10352302	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:10352302C>A	uc002gmn.2	-	31	4355	c.4244G>T	c.(4243-4245)TGT>TTT	p.C1415F	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1415	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						AAGAGAAGCACATTTGGAATT	0.453			NA											13	55					0.000151284	0.000174646	0.001855	1	0
MYH2	4620	broad.mit.edu	37	17	10441144	10441144	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:10441144G>T	uc010coi.2	-	15	1553	c.1425C>A	c.(1423-1425)AGC>AGA	p.S475R	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.S475R|MYH2_uc010coj.2_Missense_Mutation_p.S475R	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	475	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GCTGCTCCAGGCTGTTGAACT	0.368			NA											26	71					0.000117367	0.000136001	0.005443	1	0
DNAH9	1770	broad.mit.edu	37	17	11556077	11556077	+	Splice_Site	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:11556077G>C	uc002gne.2	+	14	2422	c.2354_splice	c.e14-1	p.G785_splice	DNAH9_uc010coo.2_Splice_Site_p.G79_splice	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2						cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TTGGGGAACAGGCATTTGCGA	0.363			NA											16	60					0	0	0.007413	0	0
DNAH9	1770	broad.mit.edu	37	17	11726227	11726227	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:11726227C>A	uc002gne.2	+	48	9190	c.9122C>A	c.(9121-9123)CCC>CAC	p.P3041H	DNAH9_uc010coo.2_Missense_Mutation_p.P2335H	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3041					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TATACAACTCCCAAGTCCTTT	0.478			NA											30	55					5.45727e-16	8.99807e-16	0.008361	1	0
TRIM16	10626	broad.mit.edu	37	17	15516139	15516139	+	Splice_Site	SNP	T	T	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:15516139T>G	uc002gor.1	-	11	2267	c.1930_splice	c.e11-1	p.G644_splice	CDRT1_uc002gov.3_Splice_Site_p.G334_splice			O95361	TRI16_HUMAN	SubName: Full=Putative uncharacterized protein; Flags: Fragment;						histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)		ATAGGACCCCTGGaaaaacaa	0.363			NA											25	55					0	0	0.00333	0	0
TBC1D26	353149	broad.mit.edu	37	17	15641674	15641674	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:15641674C>A	uc010cov.2	+	7	610	c.360C>A	c.(358-360)ATC>ATA	p.I120I	TBC1D26_uc010cou.1_Silent_p.I120I|TBC1D26_uc002gpb.3_RNA	NM_178571	NP_848666	Q86UD7	TBC26_HUMAN	TBC1 domain family, member 26	120	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.078)		TTGACAGAATCAAGTCCCAGA	0.502			NA											21	110					5.26018e-13	8.14138e-13	0.001882	1	0
FAM83G	644815	broad.mit.edu	37	17	18881367	18881367	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:18881367C>A	uc002guw.2	-	5	1779	c.1612G>T	c.(1612-1614)GGG>TGG	p.G538W	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	538										ovary(1)|central_nervous_system(1)	2						TGGTCTGTCCCATTCTGGGGA	0.647			NA											29	53					6.38683e-12	9.65233e-12	0.008361	1	0
NOS2	4843	broad.mit.edu	37	17	26116678	26116678	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:26116678G>A	uc002gzu.2	-	3	411	c.147C>T	c.(145-147)CTC>CTT	p.L49L	NOS2_uc010crh.1_Silent_p.L49L|NOS2_uc010wab.1_Silent_p.L49L	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	49					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GCTGCTTGCTGAGGTTGTGAT	0.483			NA											27	78					0	0	0.00632	0	0
SEZ6	124925	broad.mit.edu	37	17	27306826	27306826	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:27306826A>C	uc002hdp.2	-	3	924	c.730T>G	c.(730-732)TGT>GGT	p.C244G	SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Missense_Mutation_p.C244G|SEZ6_uc002hdq.1_Missense_Mutation_p.C119G|SEZ6_uc010crz.1_Missense_Mutation_p.C244G	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	244	Extracellular (Potential).					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			TTCCAGCTACAAGGGCCTGGG	0.488			NA											2	8					0	0	0.004672	0	0
TMEM132E	124842	broad.mit.edu	37	17	32956077	32956077	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:32956077G>A	uc002hif.2	+	5	1250	c.922G>A	c.(922-924)GAG>AAG	p.E308K		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	308	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CTTTGAAATGGAGAACTTCAC	0.622			NA											33	121					0	0	0.002096	0	0
CCL15	6359	broad.mit.edu	37	17	34325363	34325363	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:34325363C>T	uc010wcu.1	-	3	770	c.201G>A	c.(199-201)ATG>ATA	p.M67I	CCL14-CCL15_uc010wcs.1_RNA|CCL14-CCL15_uc010wct.1_RNA	NM_032965	NP_116741	Q16663	CCL15_HUMAN	chemokine (C-C motif) ligand 15 precursor	67					cell-cell signaling|cellular calcium ion homeostasis|immune response	extracellular space	chemoattractant activity|chemokine activity|heparin binding|signal transducer activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AATAACTTTTCATGAGTGAAC	0.502			NA											17	36					0	0	0.010504	0	0
GRB7	2886	broad.mit.edu	37	17	37900375	37900375	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:37900375G>T	uc002hsr.2	+	7	966	c.716G>T	c.(715-717)CGG>CTG	p.R239L	GRB7_uc002hss.2_Missense_Mutation_p.R239L|GRB7_uc010cwc.2_Missense_Mutation_p.R239L|GRB7_uc002hst.2_Missense_Mutation_p.R239L	NM_005310	NP_005301	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	239	PH.	Important for lipid binding and for stimulation of cell migration.		R->L: Abolishes phosphoinositide binding.	blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CTGCAGCTGCGGGGTTCAGGA	0.552			NA											38	210					1.07121e-22	1.88748e-22	0.006999	1	0
RARA	5914	broad.mit.edu	37	17	38510598	38510598	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:38510598G>A	uc002huk.1	+	7	1307	c.852G>A	c.(850-852)ATG>ATA	p.M284I	RARA_uc002hul.3_Missense_Mutation_p.M284I|RARA_uc010wfe.1_Missense_Mutation_p.M187I|RARA_uc002hun.1_Missense_Mutation_p.M279I	NM_000964	NP_000955	P10276	RARA_HUMAN	retinoic acid receptor, alpha isoform 1	284	Ligand-binding.				apoptotic cell clearance|cellular response to estrogen stimulus|cellular response to retinoic acid|estrogen receptor signaling pathway|negative regulation of granulocyte differentiation|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of binding|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	cytoplasm|nucleoplasm	chromatin DNA binding|enzyme binding|protein domain specific binding|protein heterodimerization activity|receptor binding|retinoic acid binding|retinoic acid receptor activity|retinoic acid-responsive element binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00143)		Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Isotretinoin(DB00982)|Tamibarotene(DB04942)|Tazarotene(DB00799)	AGGACACCATGACCTTCTCGG	0.632			NA	T	PML|ZNF145|TIF1|NUMA1|NPM1	APL								6	49					0	0	0.001168	0	0
KRTAP9-8	83901	broad.mit.edu	37	17	39394620	39394620	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:39394620A>G	uc002hwh.3	+	1	351	c.317A>G	c.(316-318)TAC>TGC	p.Y106C	KRTAP9-9_uc010wfq.1_Intron	NM_031963	NP_114169	Q9BYQ0	KRA98_HUMAN	keratin associated protein 9.8	106	15 X 5 AA repeats of C-C-[RQVSGE]- [SPSNQ]-[TASPI].					keratin filament				ovary(1)	1		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			AGAACCTGCTACCACCCCACG	0.627			NA											22	119					0	0	0.002299	0	0
JUP	3728	broad.mit.edu	37	17	39919432	39919432	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:39919432C>A	uc002hxq.2	-	8	1577	c.1300G>T	c.(1300-1302)GGT>TGT	p.G434C	JUP_uc010wfs.1_Intron|JUP_uc002hxr.2_Missense_Mutation_p.G434C|JUP_uc002hxs.2_Missense_Mutation_p.G434C	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	434	ARM 6.				adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		GCCTCCACACCGCTGTTCTGT	0.602	Colon(16;42 520 6044 17852 28530)		NA											27	50					2.44723e-14	3.90543e-14	0.004656	1	0
NAGLU	4669	broad.mit.edu	37	17	40695601	40695601	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:40695601A>G	uc002hzv.2	+	6	1917	c.1577A>G	c.(1576-1578)AAT>AGT	p.N526S		NM_000263	NP_000254	P54802	ANAG_HUMAN	alpha-N-acetylglucosaminidase precursor	526						lysosome	alpha-N-acetylglucosaminidase activity				0		all_cancers(22;1.58e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)	N-Acetyl-D-glucosamine(DB00141)	CTACAGATGAATACCAGCATC	0.637			NA											7	26					0	0	0.001984	0	0
CD300LG	146894	broad.mit.edu	37	17	41934478	41934478	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:41934478A>T	uc002iem.2	+	6	880	c.839A>T	c.(838-840)CAG>CTG	p.Q280L	CD300LG_uc002iel.1_Missense_Mutation_p.Q195L|CD300LG_uc010czk.2_Missense_Mutation_p.Q280L|CD300LG_uc010wil.1_Missense_Mutation_p.Q246L|CD300LG_uc010czl.2_Missense_Mutation_p.Q195L	NM_145273	NP_660316	Q6UXG3	CLM9_HUMAN	CD300 molecule-like family member g precursor	280	Cytoplasmic (Potential).					apical plasma membrane|basolateral plasma membrane|integral to membrane|multivesicular body membrane	receptor activity				0		Breast(137;0.0199)		BRCA - Breast invasive adenocarcinoma(366;0.115)		TCAGCTCAACAGGCCACGGAG	0.577			NA											4	42					0	0	0.009096	0	0
C17orf46	124783	broad.mit.edu	37	17	43333282	43333282	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:43333282C>T	uc002iis.1	-	4	363	c.267G>A	c.(265-267)ACG>ACA	p.T89T	LOC100133991_uc010dah.2_Intron|C17orf46_uc010wjk.1_Silent_p.T68T	NM_152343	NP_689556	Q96LK8	CQ046_HUMAN	hypothetical protein LOC124783	89										large_intestine(1)|ovary(1)	2						AGTTGGCTTCCGTGTCCAGCT	0.498			NA											42	111					0	0	0.002522	0	0
ITGB3	3690	broad.mit.edu	37	17	45376866	45376867	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:45376866_45376867CC>AA	uc002ilj.2	+	11	1903_1904	c.1883_1884CC>AA	c.(1882-1884)CCC>CAA	p.P628Q	ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	628	IV.|Extracellular (Potential).|Cysteine-rich tandem repeats.				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	GAGAAGTGCCCCACCTGCCCAG	0.609			NA											12	52					0	0	0.004672	0	0
SP2	6668	broad.mit.edu	37	17	45993740	45993740	+	Silent	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:45993740G>C	uc002imk.2	+	3	440	c.303G>C	c.(301-303)CTG>CTC	p.L101L	SP2_uc002iml.2_Silent_p.L94L|uc002imm.2_Intron	NM_003110	NP_003101	Q02086	SP2_HUMAN	Sp2 transcription factor	101					immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|histone deacetylase binding|zinc ion binding				0						GGTCACAACTGAGCGCCTCCT	0.522			NA											15	124					0	0	0.00245	0	0
COPZ2	51226	broad.mit.edu	37	17	46111234	46111234	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:46111234G>T	uc002imy.2	-	7	276	c.263C>A	c.(262-264)ACT>AAT	p.T88N		NM_016429	NP_057513	Q9P299	COPZ2_HUMAN	coatomer protein complex, subunit zeta 2	88					intracellular protein transport|vesicle-mediated transport	cis-Golgi network|COPI vesicle coat					0						CTTACTCTCAGTCCGGCTGGT	0.488			NA											3	17					6.4e-05	7.49101e-05	0.004672	1	0
COL1A1	1277	broad.mit.edu	37	17	48263689	48263689	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:48263689C>T	uc002iqm.2	-	49	4120	c.3994G>A	c.(3994-3996)GAT>AAT	p.D1332N		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	1332	Fibrillar collagen NC1.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	TGGAATCCATCGGTCATGCTC	0.572			NA	T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						6	108					0	0	0.001984	0	0
LRRC59	55379	broad.mit.edu	37	17	48474597	48474597	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:48474597T>A	uc002iqt.2	-	1	236	c.82A>T	c.(82-84)AAT>TAT	p.N28Y		NM_018509	NP_060979	Q96AG4	LRC59_HUMAN	leucine rich repeat containing 59	28	Cytoplasmic (Potential).|LRR 1.					endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial nucleoid	protein binding			central_nervous_system(1)	1	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)			GGGACCTCATTCAGGTCGCTG	0.612			NA									OREG0024565	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	71					0	0	0.004482	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48600956	48600956	+	Splice_Site	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:48600956A>T	uc010wmr.1	+	12	1739	c.1577_splice	c.e12-2	p.G526_splice	MYCBPAP_uc002iqz.2_Splice_Site	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein						cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			TGTCCCTCTCAGGTGTGATTC	0.493			NA											27	54					0	0	0.00632	0	0
CACNA1G	8913	broad.mit.edu	37	17	48684342	48684342	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:48684342G>T	uc002irk.1	+	24	4876	c.4504G>T	c.(4504-4506)GAC>TAC	p.D1502Y	CACNA1G_uc002irj.1_Missense_Mutation_p.D1479Y|CACNA1G_uc002irl.1_Missense_Mutation_p.D1479Y|CACNA1G_uc002irm.1_Missense_Mutation_p.D1479Y|CACNA1G_uc002irn.1_Missense_Mutation_p.D1479Y|CACNA1G_uc002iro.1_Missense_Mutation_p.D1479Y|CACNA1G_uc002irp.1_Missense_Mutation_p.D1502Y|CACNA1G_uc002irq.1_Missense_Mutation_p.D1479Y|CACNA1G_uc002irr.1_Missense_Mutation_p.D1502Y|CACNA1G_uc002irs.1_Missense_Mutation_p.D1502Y|CACNA1G_uc002irt.1_Missense_Mutation_p.D1502Y|CACNA1G_uc002irv.1_Missense_Mutation_p.D1502Y|CACNA1G_uc002irw.1_Missense_Mutation_p.D1479Y|CACNA1G_uc002iru.1_Missense_Mutation_p.D1479Y|CACNA1G_uc002irx.1_Missense_Mutation_p.D1415Y|CACNA1G_uc002iry.1_Missense_Mutation_p.D1415Y|CACNA1G_uc002irz.1_Missense_Mutation_p.D1415Y|CACNA1G_uc002isa.1_Missense_Mutation_p.D1415Y|CACNA1G_uc002isb.1_Missense_Mutation_p.D1415Y|CACNA1G_uc002isc.1_Missense_Mutation_p.D1415Y|CACNA1G_uc002isd.1_Missense_Mutation_p.D1415Y|CACNA1G_uc002ise.1_Missense_Mutation_p.D1415Y|CACNA1G_uc002isf.1_Missense_Mutation_p.D1415Y|CACNA1G_uc002isg.1_Missense_Mutation_p.D1415Y|CACNA1G_uc002ish.1_Missense_Mutation_p.D1415Y|CACNA1G_uc002isi.1_Missense_Mutation_p.D1392Y|CACNA1G_uc002isj.2_Missense_Mutation_p.D226Y	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1502	Extracellular (Potential).|III.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TGTGGGCGTGGACCAGCAGGT	0.582			NA											8	42					3.09899e-07	3.99367e-07	0.004482	1	0
KIF2B	84643	broad.mit.edu	37	17	51901776	51901776	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:51901776G>C	uc002iua.2	+	1	1538	c.1382G>C	c.(1381-1383)AGC>ACC	p.S461T	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	461	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						ACCAAGGCCAGCCGGAAAAGG	0.488			NA											8	38					0	0	0.004482	0	0
OR4D2	124538	broad.mit.edu	37	17	56247902	56247902	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:56247902G>A	uc010wnp.1	+	1	886	c.886G>A	c.(886-888)GCA>ACA	p.A296T		NM_001004707	NP_001004707	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						GGACATGCAGGCAGCAGTGAG	0.512			NA											14	105					0	0	0.00245	0	0
HSF5	124535	broad.mit.edu	37	17	56557394	56557394	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:56557394G>A	uc002iwi.1	-	2	909	c.785C>T	c.(784-786)CCA>CTA	p.P262L		NM_001080439	NP_001073908	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	262						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AACCTCAGTTGGAAACCTCTG	0.463			NA											14	208					0	0	0.001855	0	0
KCNH6	81033	broad.mit.edu	37	17	61623234	61623234	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:61623234C>T	uc002jay.2	+	14	3036	c.2956C>T	c.(2956-2958)CCT>TCT	p.P986S	KCNH6_uc010wpl.1_Missense_Mutation_p.P827S|KCNH6_uc010wpm.1_Missense_Mutation_p.P950S|KCNH6_uc002jaz.1_Missense_Mutation_p.P897S	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	986	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	TGGCTCAGATCCTGGATTTGC	0.537			NA											9	62					0	0	0.004482	0	0
SCN4A	6329	broad.mit.edu	37	17	62025346	62025346	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:62025346G>T	uc002jds.1	-	17	3299	c.3222C>A	c.(3220-3222)TAC>TAA	p.Y1074*		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1074	III.|Helical; Name=S2 of repeat III; (Potential).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	TGATGAAGATGTAGGTGAAGA	0.547			NA											23	23					3.8784e-16	6.40165e-16	0.001882	1	0
BPTF	2186	broad.mit.edu	37	17	65962715	65962715	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:65962715G>C	uc002jgf.2	+	26	8543	c.8482G>C	c.(8482-8484)GAA>CAA	p.E2828Q	BPTF_uc002jge.2_Missense_Mutation_p.E2811Q|BPTF_uc002jgg.2_Missense_Mutation_p.E543Q|BPTF_uc002jgh.2_Missense_Mutation_p.E345Q	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2954	Bromo.				brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			GCCTTTCCTTGAACCAGTAGA	0.373			NA											7	91					0	0	0.004482	0	0
ABCA6	23460	broad.mit.edu	37	17	67103890	67103890	+	Nonsense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:67103890G>C	uc002jhw.1	-	18	2511	c.2336C>G	c.(2335-2337)TCA>TGA	p.S779*	ABCA6_uc002jhx.1_Nonsense_Mutation_p.S232*	NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	779					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					ATTTAGAGTTGACATGGAAAT	0.353			NA											6	72					0	0	0.001168	0	0
KCNJ16	3773	broad.mit.edu	37	17	68128375	68128375	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:68128375C>A	uc002jin.2	+	5	633	c.147C>A	c.(145-147)CAC>CAA	p.H49Q	KCNJ16_uc002jio.2_Missense_Mutation_p.H49Q|KCNJ16_uc002jip.2_Missense_Mutation_p.H49Q|KCNJ16_uc002jiq.2_Missense_Mutation_p.H81Q	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	49	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					ACTTCAAGCACATTTTTGGAG	0.423			NA											10	123					7.48243e-07	9.50738e-07	0.006214	1	0
RNF213	57674	broad.mit.edu	37	17	78319272	78319272	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:78319272G>T	uc002jyh.1	+	4	1579	c.1356G>T	c.(1354-1356)CTG>CTT	p.L452L		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GGCTCTGCCTGACCTTAGGGA	0.547			NA											13	78					9.05144e-12	1.36525e-11	0.001855	1	0
NPTX1	4884	broad.mit.edu	37	17	78444785	78444785	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:78444785A>C	uc002jyp.1	-	5	1285	c.1127T>G	c.(1126-1128)CTG>CGG	p.L376R		NM_002522	NP_002513	Q15818	NPTX1_HUMAN	neuronal pentraxin I precursor	376	Pentaxin.				central nervous system development|synaptic transmission|transport	transport vesicle	metal ion binding				0	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			GAAGTGGGCCAGCTCACCCAC	0.607			NA											4	59					0	0	0.000602	0	0
NPLOC4	55666	broad.mit.edu	37	17	79573732	79573732	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:79573732G>C	uc002kat.3	-	7	821	c.639C>G	c.(637-639)ATC>ATG	p.I213M	NPLOC4_uc002kau.3_Missense_Mutation_p.I213M|NPLOC4_uc010wur.1_Missense_Mutation_p.I52M	NM_017921	NP_060391	Q8TAT6	NPL4_HUMAN	nuclear protein localization 4	213					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			TGTTCAGCGTGATGGCGCTCG	0.522			NA											10	57					0	0	0.008291	0	0
HGS	9146	broad.mit.edu	37	17	79662893	79662893	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:79662893C>T	uc002kbg.2	+	15	1334	c.1257C>T	c.(1255-1257)TTC>TTT	p.F419F		NM_004712	NP_004703	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine	419	Interaction with SNX1 (By similarity).				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			TCACCACCTTCGTGAACCGCA	0.607			NA											5	46					0	0	0.001168	0	0
ARHGAP28	79822	broad.mit.edu	37	18	6896572	6896572	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:6896572C>T	uc010wzi.1	+	15	1684	c.1446C>T	c.(1444-1446)CTC>CTT	p.L482L	ARHGAP28_uc002knc.2_Silent_p.L607L|ARHGAP28_uc002knd.2_Silent_p.L500L|ARHGAP28_uc002kne.2_Silent_p.L500L|ARHGAP28_uc002knf.2_Silent_p.L491L			B4DXL2	B4DXL2_HUMAN	SubName: Full=Putative uncharacterized protein ARHGAP28;	482					signal transduction	intracellular				pancreas(1)	1		Colorectal(10;0.168)				CCATTCAACTCAACAATCAAA	0.443			NA											11	68					0	0	0.008291	0	0
MC2R	4158	broad.mit.edu	37	18	13885213	13885213	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:13885213G>A	uc002ksp.1	-	2	482	c.305C>T	c.(304-306)GCC>GTC	p.A102V		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	102	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	GATGTCATCGGCTGTGGTTTC	0.488	Colon(141;1584 1782 35999 48227 48692)		NA											14	57					0	0	0.003163	0	0
CABYR	26256	broad.mit.edu	37	18	21735704	21735704	+	Nonsense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:21735704T>A	uc002kux.2	+	4	391	c.239T>A	c.(238-240)TTA>TAA	p.L80*	CABYR_uc010xbb.1_5'UTR|CABYR_uc002kuy.2_Nonsense_Mutation_p.L80*|CABYR_uc002kuz.2_Nonsense_Mutation_p.L80*|CABYR_uc002kva.2_Nonsense_Mutation_p.L62*|CABYR_uc002kvb.2_5'UTR|CABYR_uc002kvc.2_Nonsense_Mutation_p.L80*|CABYR_uc010dlw.2_RNA	NM_012189	NP_036321	O75952	CABYR_HUMAN	calcium-binding tyrosine	80					ciliary or flagellar motility|signal transduction|sperm capacitation	cytoplasm|cytoskeleton|flagellum|motile cilium|nucleus	calcium ion binding|cAMP-dependent protein kinase regulator activity|enzyme binding|protein heterodimerization activity|SH3 domain binding				0	all_cancers(21;9.13e-05)|all_epithelial(16;5.49e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0305)|Ovarian(20;0.17)					CAGAAGAAATTAGAATGTTTA	0.348			NA											21	69					0	0	0.001882	0	0
ZNF521	25925	broad.mit.edu	37	18	22806254	22806254	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:22806254C>A	uc002kvk.2	-	4	1875	c.1628G>T	c.(1627-1629)CGA>CTA	p.R543L	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.R543L|ZNF521_uc002kvl.2_Missense_Mutation_p.R323L	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	543					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					AGACCCAAATCGGGAGCCACT	0.433			NA	T	PAX5	ALL								14	87					2.31682e-05	2.7594e-05	0.003163	1	0
ZNF521	25925	broad.mit.edu	37	18	22807073	22807073	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:22807073G>T	uc002kvk.2	-	4	1056	c.809C>A	c.(808-810)CCC>CAC	p.P270H	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.P270H|ZNF521_uc002kvl.2_Missense_Mutation_p.P50H	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	270					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GGAGCATTCGGGGTGGCACTC	0.552			NA	T	PAX5	ALL								10	102					5.16669e-11	7.65803e-11	0.000978	1	0
ZNF521	25925	broad.mit.edu	37	18	22807426	22807426	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:22807426A>C	uc002kvk.2	-	4	703	c.456T>G	c.(454-456)AGT>AGG	p.S152R	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.S152R|ZNF521_uc002kvl.2_5'UTR	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	152	C2H2-type 3.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TGAACAGCCTACTGCAGTAGG	0.498			NA	T	PAX5	ALL								30	115					0	0	0.009535	0	0
DSG1	1828	broad.mit.edu	37	18	28914145	28914145	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:28914145G>T	uc002kwp.2	+	8	1197	c.985G>T	c.(985-987)GGA>TGA	p.G329*		NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	329	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			AACAAATGTGGGAATTTTAAA	0.279			NA											14	81					1.41608e-15	2.31503e-15	0.001855	1	0
C18orf34	374864	broad.mit.edu	37	18	30992007	30992007	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:30992007G>T	uc002kxn.2	-	2	188	c.46C>A	c.(46-48)CAA>AAA	p.Q16K	C18orf34_uc010xbr.1_Missense_Mutation_p.Q16K|C18orf34_uc010dmf.1_Missense_Mutation_p.Q16K|C18orf34_uc002kxo.2_Missense_Mutation_p.Q16K|C18orf34_uc002kxp.2_Missense_Mutation_p.Q16K	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	16										ovary(1)	1						ATATTGGTTTGATCATCTCTA	0.269			NA											9	38					0.000151284	0.000174646	0.001855	1	0
DTNA	1837	broad.mit.edu	37	18	32459649	32459649	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:32459649A>T	uc010dmn.1	+	19	2048	c.2047A>T	c.(2047-2049)AGT>TGT	p.S683C	DTNA_uc002kxw.2_Missense_Mutation_p.S626C|DTNA_uc010dmj.2_Missense_Mutation_p.S623C|DTNA_uc002kxz.2_Missense_Mutation_p.S630C|DTNA_uc002kxy.2_Missense_Mutation_p.S623C|DTNA_uc010xby.1_Missense_Mutation_p.S373C|DTNA_uc010xbz.1_Missense_Mutation_p.S392C|DTNA_uc010xca.1_Missense_Mutation_p.S335C|DTNA_uc002kye.2_Missense_Mutation_p.S331C	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	683					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						GTACATTCACAGTGGAGCTAC	0.453			NA											11	53					0	0	0.000978	0	0
MAPRE2	10982	broad.mit.edu	37	18	32682021	32682021	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:32682021G>T	uc002kyg.2	+	4	688	c.508G>T	c.(508-510)GTA>TTA	p.V170L	MAPRE2_uc010xcb.1_Missense_Mutation_p.V127L|MAPRE2_uc010xcc.1_Missense_Mutation_p.V158L|MAPRE2_uc002kyf.2_Missense_Mutation_p.V170L|MAPRE2_uc002kyh.2_Missense_Mutation_p.V117L|MAPRE2_uc010xcd.1_Missense_Mutation_p.V127L	NM_014268	NP_055083	Q15555	MARE2_HUMAN	microtubule-associated protein, RP/EB family,	170					cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			ovary(1)	1						GTATGATCCTGTAGAGGCACG	0.463			NA											14	74					1.3612e-06	1.72248e-06	0.003163	1	0
KIAA1328	57536	broad.mit.edu	37	18	34539372	34539372	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:34539372G>A	uc002kzz.2	+	6	572	c.550G>A	c.(550-552)GGT>AGT	p.G184S	KIAA1328_uc002lab.2_Intron|KIAA1328_uc002lac.1_Missense_Mutation_p.G7S|KIAA1328_uc010dnc.1_RNA	NM_020776	NP_065827	Q86T90	K1328_HUMAN	hypothetical protein LOC57536	184										central_nervous_system(1)	1				COAD - Colon adenocarcinoma(74;0.195)		CTCAGAACTTGGTGCTGCTAG	0.388			NA											8	16					0	0	0.004482	0	0
SYT4	6860	broad.mit.edu	37	18	40853935	40853935	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:40853935C>T	uc002law.2	-	2	828	c.459G>A	c.(457-459)AAG>AAA	p.K153K	SYT4_uc010dng.2_Intron|SYT4_uc010xcm.1_Silent_p.K135K|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	153	Phospholipid binding (Probable).|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						GAGTTCCCAGCTTCTCTTGTT	0.453	NSCLC(85;81 1419 2855 22820 35912)		NA											6	49					0	0	0.001168	0	0
KIAA1632	57724	broad.mit.edu	37	18	43493755	43493755	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:43493755G>C	uc002lbm.2	-	21	3832	c.3732C>G	c.(3730-3732)ATC>ATG	p.I1244M	KIAA1632_uc002lbo.1_Missense_Mutation_p.I1244M|KIAA1632_uc010xcq.1_Translation_Start_Site|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.I119M	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1244					autophagy						0						CCTCTTCAAAGATGGATTCCA	0.493			NA											13	89					0	0	0.001855	0	0
TCEB3B	51224	broad.mit.edu	37	18	44560607	44560607	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:44560607G>C	uc002lcr.1	-	1	1382	c.1029C>G	c.(1027-1029)GAC>GAG	p.D343E	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	343					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						GAGTCTCTCGGTCGTTGGAAA	0.577			NA											19	75					0	0	0.007413	0	0
TCEB3B	51224	broad.mit.edu	37	18	44560667	44560667	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:44560667C>T	uc002lcr.1	-	1	1322	c.969G>A	c.(967-969)CGG>CGA	p.R323R	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	323					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						TTCCTGGGTCCCGGCCGTCTA	0.612			NA											36	103					0	0	0.003271	0	0
DCC	1630	broad.mit.edu	37	18	50994380	50994380	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:50994380G>T	uc002lfe.1	+	25	4323	c.3736G>T	c.(3736-3738)GCT>TCT	p.A1246S	DCC_uc010dpf.1_Missense_Mutation_p.A881S	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1246	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CAACAATCCTGGTGAGTCAAT	0.448			NA											15	41					2.23348e-06	2.78733e-06	0.004007	1	0
C18orf26	284254	broad.mit.edu	37	18	52258503	52258503	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:52258503G>T	uc002lfq.1	+	1	114	c.68G>T	c.(67-69)GGC>GTC	p.G23V	C18orf26_uc002lfp.1_Missense_Mutation_p.G26V	NM_173629	NP_775900	Q8N1N2	CR026_HUMAN	hypothetical protein LOC284254	23						integral to membrane					0				Colorectal(16;0.0193)|READ - Rectum adenocarcinoma(59;0.178)		TGTGATACTGGCAGCTCAAGA	0.393			NA											25	60					1.36565e-18	2.32901e-18	0.00278	1	0
CDH19	28513	broad.mit.edu	37	18	64178885	64178885	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:64178885G>T	uc002lkc.1	-	10	1634	c.1496C>A	c.(1495-1497)TCC>TAC	p.S499Y	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Intron	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	499	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				CTCTTCTATGGATTCATCTCT	0.333			NA											19	53					1.67942e-08	2.29485e-08	0.006122	1	0
RTTN	25914	broad.mit.edu	37	18	67741202	67741202	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:67741202C>A	uc002lkp.2	-	34	4661	c.4593G>T	c.(4591-4593)AGG>AGT	p.R1531S	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Missense_Mutation_p.R619S	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	1531							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				TAGATGGAGCCCTCCAAAACT	0.408			NA											23	37					1.64293e-13	2.56865e-13	0.00333	1	0
CNDP1	84735	broad.mit.edu	37	18	72247446	72247446	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:72247446C>A	uc002llq.2	+	10	1459	c.1248C>A	c.(1246-1248)CAC>CAA	p.H416Q	CNDP1_uc002lls.2_Missense_Mutation_p.H219Q	NM_032649	NP_116038	Q96KN2	CNDP1_HUMAN	carnosinase 1 precursor	416					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity				0		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		TAGGACTACACCCGTGGATTG	0.433	Melanoma(32;1029 1042 25286 38395 44237)		NA											9	21					7.48243e-07	9.50738e-07	0.006214	1	0
ADNP2	22850	broad.mit.edu	37	18	77893726	77893726	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr18:77893726G>A	uc002lnw.2	+	4	885	c.430G>A	c.(430-432)GAA>AAA	p.E144K		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	144					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		TATTTTAGGTGAAACTAAATC	0.408			NA											8	69					0	0	0.00308	0	0
PPAP2C	8612	broad.mit.edu	37	19	288086	288086	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:288086G>A	uc002loi.2	-	2	237	c.138C>T	c.(136-138)CCC>CCT	p.P46P	PPAP2C_uc002loh.2_Silent_p.P67P|PPAP2C_uc002loj.2_5'UTR	NM_003712	NP_003703	O43688	LPP2_HUMAN	phosphatidic acid phosphatase type 2C isoform 1	46					sphingolipid metabolic process	integral to membrane|plasma membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGGACGGTAGGGGTACCGGA	0.612			NA											7	97					0	0	0.006214	0	0
PRSSL1	400668	broad.mit.edu	37	19	694911	694911	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:694911A>T	uc002lpl.1	-	2	170	c.139T>A	c.(139-141)TAC>AAC	p.Y47N	PRSSL1_uc010xfs.1_Missense_Mutation_p.Y46N	NM_214710	NP_999875	Q6UWY2	PRS57_HUMAN	protease, serine-like 1 precursor	47	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GATGCCATGTAGGGCCTGGAG	0.701			NA											4	11					0	0	0.009096	0	0
GRIN3B	116444	broad.mit.edu	37	19	1008897	1008897	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:1008897G>A	uc002lqo.1	+	8	2673	c.2673G>A	c.(2671-2673)TCG>TCA	p.S891S	uc002lqp.1_RNA	NM_138690	NP_619635	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic,	891	Cytoplasmic (Potential).				ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CAGAGGGGTCGAAGGAGGAGA	0.577			NA											3	11					0	0	0.004672	0	0
FAM108A1	81926	broad.mit.edu	37	19	1881444	1881444	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:1881444G>A	uc002lug.2	-	2	528	c.122C>T	c.(121-123)CCC>CTC	p.P41L	FAM108A1_uc002lud.2_Missense_Mutation_p.P41L|FAM108A1_uc002lue.2_Missense_Mutation_p.P41L|FAM108A1_uc002luf.2_Missense_Mutation_p.P41L	NM_001130111	NP_001123583	Q96GS6	F18A1_HUMAN	hypothetical protein LOC81926 isoform 2	41						extracellular region	hydrolase activity				0		Ovarian(11;0.000137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCCGGCTCGGGCTCAGGCAC	0.756			NA											7	50					0	0	0.006214	0	0
LMNB2	84823	broad.mit.edu	37	19	2444466	2444466	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:2444466C>G	uc002lvy.2	-	2	364	c.277G>C	c.(277-279)GAG>CAG	p.E93Q	LMNB2_uc002lwa.1_Missense_Mutation_p.E113Q	NM_032737	NP_116126	Q03252	LMNB2_HUMAN	lamin B2	93	Rod.|Coil 1B.					nuclear inner membrane	structural molecule activity			large_intestine(1)|ovary(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGGCACGCTCTCGAGCCGTC	0.627			NA											6	47					0	0	0.001168	0	0
NFIC	4782	broad.mit.edu	37	19	3381731	3381731	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:3381731G>C	uc010xhi.1	+	2	114	c.52G>C	c.(52-54)GAG>CAG	p.E18Q	NFIC_uc002lxo.2_Missense_Mutation_p.E9Q|NFIC_uc010xhh.1_Missense_Mutation_p.E9Q|NFIC_uc002lxp.2_Missense_Mutation_p.E18Q|NFIC_uc010xhj.1_Missense_Mutation_p.E18Q|NFIC_uc002lxq.1_5'UTR	NM_205843	NP_995315	P08651	NFIC_HUMAN	nuclear factor I/C isoform 2	18	CTF/NF-I.				DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		CCCGTTCATCGAGGCCCTGCT	0.657			NA											12	24					0	0	0.001368	0	0
NFIC	4782	broad.mit.edu	37	19	3381733	3381733	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:3381733G>T	uc010xhi.1	+	2	116	c.54G>T	c.(52-54)GAG>GAT	p.E18D	NFIC_uc002lxo.2_Missense_Mutation_p.E9D|NFIC_uc010xhh.1_Missense_Mutation_p.E9D|NFIC_uc002lxp.2_Missense_Mutation_p.E18D|NFIC_uc010xhj.1_Missense_Mutation_p.E18D|NFIC_uc002lxq.1_Translation_Start_Site	NM_205843	NP_995315	P08651	NFIC_HUMAN	nuclear factor I/C isoform 2	18	CTF/NF-I.				DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		CGTTCATCGAGGCCCTGCTGC	0.657			NA											12	24					2.68362e-12	4.09186e-12	0.001368	1	0
MATK	4145	broad.mit.edu	37	19	3785124	3785124	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:3785124G>T	uc002lyt.2	-	2	410	c.10C>A	c.(10-12)CGA>AGA	p.R4R	MATK_uc002lyv.2_Intron|MATK_uc002lyu.2_Intron|MATK_uc010dtq.2_Silent_p.R4R	NM_139355	NP_647612	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase isoform	4					cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(2)|ovary(1)|lung(1)|large_intestine(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		AGAGAGCCTCGCCCCGCCATC	0.627			NA											6	19					0.00198382	0.00218689	0.001984	1	0
GPR108	56927	broad.mit.edu	37	19	6732044	6732044	+	Silent	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:6732044G>C	uc002mfp.2	-	13	1294	c.1248C>G	c.(1246-1248)CCC>CCG	p.P416P	GPR108_uc010duv.2_5'UTR|GPR108_uc002mfn.2_Silent_p.P87P|GPR108_uc002mfo.3_Silent_p.P174P|GPR108_uc010duw.2_RNA	NM_001080452	NP_001073921	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108 isoform 1	416	Helical; Name=5; (Potential).					integral to membrane					0						ACCAGACTACGGGGAACAGGA	0.622			NA											4	27					0	0	0.009096	0	0
MUC16	94025	broad.mit.edu	37	19	9058698	9058698	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:9058698G>T	uc002mkp.2	-	3	28952	c.28748C>A	c.(28747-28749)CCT>CAT	p.P9583H		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9585	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCTCAGTCCAGGGGTCAGAGA	0.512			NA											9	39					7.48243e-07	9.50738e-07	0.006214	1	0
MUC16	94025	broad.mit.edu	37	19	9059073	9059073	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:9059073G>T	uc002mkp.2	-	3	28577	c.28373C>A	c.(28372-28374)TCC>TAC	p.S9458Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9460	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GACAGGAGAGGAGTGGCTACT	0.483			NA											33	87					2.46105e-21	4.28735e-21	0.002096	1	0
MUC16	94025	broad.mit.edu	37	19	9070836	9070836	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:9070836G>C	uc002mkp.2	-	3	16814	c.16610C>G	c.(16609-16611)CCC>CGC	p.P5537R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5539	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGCTATTGTGGGCCGATCAAG	0.483			NA											5	127					0	0	0.000602	0	0
MUC16	94025	broad.mit.edu	37	19	9075173	9075173	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:9075173C>G	uc002mkp.2	-	3	12477	c.12273G>C	c.(12271-12273)ATG>ATC	p.M4091I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4093	Thr-rich.|Extracellular (Potential).|Ser-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TAGCAAGGATCATTCCTCCAG	0.527			NA											21	48					0	0	0.001882	0	0
MUC16	94025	broad.mit.edu	37	19	9082767	9082767	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:9082767G>T	uc002mkp.2	-	1	9252	c.9048C>A	c.(9046-9048)CTC>CTA	p.L3016L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3017	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGTGCTGAAGAGAGTTGTGA	0.493			NA											24	94					1.64293e-13	2.56865e-13	0.00333	1	0
OR7G1	125962	broad.mit.edu	37	19	9226195	9226195	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:9226195A>G	uc002mks.1	-	1	245	c.245T>C	c.(244-246)CTA>CCA	p.L82P		NM_001005192	NP_001005192	Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G,	82	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						GATGTTCACTAGGATCTTTGG	0.458			NA											48	120					0	0	0.00361	0	0
DNMT1	1786	broad.mit.edu	37	19	10249218	10249218	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:10249218C>G	uc002mng.2	-	34	4144	c.3964G>C	c.(3964-3966)GAG>CAG	p.E1322Q	DNMT1_uc002mne.2_RNA|DNMT1_uc002mnf.2_Missense_Mutation_p.E246Q|DNMT1_uc010xlc.1_Missense_Mutation_p.E1338Q|DNMT1_uc002mnh.2_Missense_Mutation_p.E1217Q|DNMT1_uc010xld.1_Missense_Mutation_p.E1322Q	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	1322	Catalytic.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	GGGAGCTTCTCTCCAGGGGCC	0.642			NA											6	52					0	0	0.001168	0	0
GCDH	2639	broad.mit.edu	37	19	13004356	13004356	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:13004356C>G	uc002mvq.2	+	6	471	c.394C>G	c.(394-396)CGG>GGG	p.R132G	GCDH_uc010xms.1_Missense_Mutation_p.R99G|GCDH_uc002mvp.2_Missense_Mutation_p.R132G|GCDH_uc010xmt.1_5'UTR|GCDH_uc010xmu.1_Missense_Mutation_p.R88G	NM_000159	NP_000150	Q92947	GCDH_HUMAN	glutaryl-Coenzyme A dehydrogenase isoform a	132					lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding				0						AGAGCTGGAGCGGGTGGACAG	0.587	GBM(123;875 1636 7726 16444 26754)		NA											14	58					0	0	0.00245	0	0
EMR2	30817	broad.mit.edu	37	19	14875407	14875407	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:14875407G>A	uc002mzp.1	-	11	1378	c.922C>T	c.(922-924)CTG>TTG	p.L308L	EMR2_uc010dzs.1_5'UTR|EMR2_uc010xnw.1_Silent_p.L308L|EMR2_uc002mzo.1_Silent_p.L308L|EMR2_uc002mzq.1_Silent_p.L259L|EMR2_uc002mzr.1_Silent_p.L259L|EMR2_uc002mzs.1_Silent_p.L166L|EMR2_uc002mzt.1_Silent_p.L215L|EMR2_uc002mzu.1_Silent_p.L215L|EMR2_uc010xnx.1_RNA|EMR2_uc010xny.1_RNA	NM_013447	NP_038475	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone	308	Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			lung(2)|ovary(1)|skin(1)	4						AGCTCATCCAGCGCCTGTAAG	0.627			NA											9	15					0	0	0.006214	0	0
ILVBL	10994	broad.mit.edu	37	19	15230306	15230306	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:15230306G>T	uc002nam.2	-	8	958	c.837C>A	c.(835-837)ATC>ATA	p.I279I	ILVBL_uc010xof.1_5'Flank|ILVBL_uc010dzw.2_Silent_p.I172I	NM_006844	NP_006835	A1L0T0	ILVBL_HUMAN	ilvB (bacterial acetolactate synthase)-like	279						integral to membrane	magnesium ion binding|thiamine pyrophosphate binding|transferase activity			ovary(2)	2						CCCGGCTCAGGATCTCCACAC	0.493			NA											4	35					0.00024832	0.000283269	0.009096	1	0
CYP4F3	4051	broad.mit.edu	37	19	15757873	15757873	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:15757873C>A	uc002nbj.2	+	4	405	c.355C>A	c.(355-357)CCA>ACA	p.P119T	CYP4F3_uc010xok.1_Missense_Mutation_p.P119T|CYP4F3_uc010xol.1_Missense_Mutation_p.P119T|CYP4F3_uc010xom.1_5'UTR|CYP4F3_uc002nbk.2_Missense_Mutation_p.P119T|CYP4F3_uc010xon.1_5'Flank	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	119					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						TGCCATTGTACCAAAGGACAA	0.567			NA											15	87					9.16793e-09	1.26738e-08	0.00499	1	0
CYP4F12	66002	broad.mit.edu	37	19	15784338	15784338	+	Splice_Site	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:15784338G>A	uc002nbl.2	+	2	61	c.0_splice	c.e2-1		CYP4F12_uc010xoo.1_Splice_Site|CYP4F12_uc010xop.1_Splice_Site	NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					CTGCCCTGCAGGATGTCGCTG	0.672			NA											5	58					0	0	0.000602	0	0
RAB8A	4218	broad.mit.edu	37	19	16222769	16222769	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:16222769G>T	uc002ndn.3	+	1	280	c.58G>T	c.(58-60)GGG>TGG	p.G20W	RAB8A_uc002ndm.1_Missense_Mutation_p.G20W|RAB8A_uc010xpc.1_Missense_Mutation_p.G20W	NM_005370	NP_005361	P61006	RAB8A_HUMAN	mel transforming oncogene	20	GTP (By similarity).				cilium assembly|Golgi vesicle fusion to target membrane|protein transport|small GTPase mediated signal transduction|vesicle docking involved in exocytosis	Golgi apparatus|nonmotile primary cilium|perinuclear region of cytoplasm|plasma membrane	GTP binding|protein binding			skin(1)	1						CTCGGGGGTGGGGAAGACCTG	0.607			NA											53	133					3.31993e-32	6.22739e-32	0.00361	1	0
NXNL1	115861	broad.mit.edu	37	19	17571646	17571646	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:17571646G>T	uc002ngs.2	-	1	80	c.33C>A	c.(31-33)ATC>ATA	p.I11I		NM_138454	NP_612463	Q96CM4	NXNL1_HUMAN	nucleoredoxin-like 1	11	Thioredoxin.				cell redox homeostasis	nuclear outer membrane					0						TATTGTTGCGGATCAGGATGC	0.637			NA											19	48					0.000132079	0.000152819	0.008871	1	0
IL12RB1	3594	broad.mit.edu	37	19	18170764	18170764	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:18170764G>A	uc002nhw.1	-	16	1987	c.1923C>T	c.(1921-1923)GCC>GCT	p.A641A	IL12RB1_uc010xqb.1_Silent_p.A641A|IL12RB1_uc002nhx.1_Silent_p.A681A	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	641	Cytoplasmic (Potential).				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						CCAGCTCAGGGGCACCCTCAG	0.622			NA											4	6					0	0	0.009096	0	0
ZNF208	7757	broad.mit.edu	37	19	22154744	22154744	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:22154744C>A	uc002nqp.2	-	6	2857	c.2708G>T	c.(2707-2709)TGT>TTT	p.C903F	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACATTCTTCACATTTGTAGGG	0.418			NA											35	73					4.34311e-12	6.57658e-12	0.003271	1	0
ZNF208	7757	broad.mit.edu	37	19	22155075	22155075	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:22155075C>G	uc002nqp.2	-	5	2610	c.2461G>C	c.(2461-2463)GAA>CAA	p.E821Q	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTGCCACATTCTTCACATTTG	0.388			NA											6	43					0	0	0.001168	0	0
ZNF208	7757	broad.mit.edu	37	19	22155565	22155565	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:22155565G>T	uc002nqp.2	-	5	2120	c.1971C>A	c.(1969-1971)GCC>GCA	p.A657A	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACCACTTATAGGCTTTGCCAC	0.368			NA											19	28					3.83957e-06	4.73793e-06	0.00278	1	0
ZNF492	57615	broad.mit.edu	37	19	22847748	22847748	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:22847748G>T	uc002nqw.3	+	4	1521	c.1277G>T	c.(1276-1278)TGT>TTT	p.C426F		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	426	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				TGTGAAGAATGTGGCAAAGCT	0.358			NA											15	75					1.87028e-06	2.35121e-06	0.001882	1	0
CCNE1	898	broad.mit.edu	37	19	30303884	30303884	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:30303884G>A	uc002nsn.2	+	4	303	c.120G>A	c.(118-120)CAG>CAA	p.Q40Q	CCNE1_uc002nso.2_Silent_p.Q25Q	NM_001238	NP_001229	P24864	CCNE1_HUMAN	cyclin E1 isoform 1	40					androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity			lung(2)	2	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)			AGTTTTTGCAGGATCCAGATG	0.527			NA											41	59					0	0	0.002522	0	0
KCTD15	79047	broad.mit.edu	37	19	34302440	34302440	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:34302440C>G	uc002nuy.3	+	6	944	c.676C>G	c.(676-678)CGG>GGG	p.R226G	KCTD15_uc002nuv.2_Missense_Mutation_p.R226G|KCTD15_uc002nuw.3_Missense_Mutation_p.R226G|KCTD15_uc010xrt.1_Missense_Mutation_p.R226G|KCTD15_uc002nux.3_Missense_Mutation_p.R226G	NM_001129994	NP_001123466	Q96SI1	KCD15_HUMAN	potassium channel tetramerisation domain	226						voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1	Esophageal squamous(110;0.162)					TGGCTACTGCCGGCTCAACTC	0.697	Melanoma(36;646 1094 5145 14504 45302)|GBM(25;193 541 1518 14388 52178)		NA											17	20					0	0	0.004007	0	0
ZFP14	57677	broad.mit.edu	37	19	36831385	36831385	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:36831385C>G	uc002odx.1	-	4	1436	c.1343G>C	c.(1342-1344)GGT>GCT	p.G448A	ZFP14_uc010xtd.1_Missense_Mutation_p.G449A|ZFP14_uc010eex.1_Missense_Mutation_p.G448A	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					AGGTTTCTCACCAGTGTGAAT	0.403			NA											4	121					0	0	0.009096	0	0
ZNF260	339324	broad.mit.edu	37	19	37005747	37005747	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:37005747C>T	uc002oee.1	-	4	1238	c.394G>A	c.(394-396)GGA>AGA	p.G132R	ZNF260_uc002oed.1_Missense_Mutation_p.G129R|ZNF260_uc010eey.1_Missense_Mutation_p.G129R|ZNF260_uc002oef.1_Missense_Mutation_p.G129R	NM_001012756	NP_001012774	Q3ZCT1	ZN260_HUMAN	zinc finger protein 260	132					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					GGTTTGGTTCCTGTATGATTT	0.388			NA											106	129					0	0	0.00361	0	0
MAP4K1	11184	broad.mit.edu	37	19	39103297	39103297	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:39103297C>A	uc002oix.1	-	9	727	c.619G>T	c.(619-621)GAA>TAA	p.E207*	MAP4K1_uc002oiy.1_Nonsense_Mutation_p.E207*|MAP4K1_uc010xug.1_5'UTR	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	207	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TCGGCCAGTTCGATGGCCGTG	0.627			NA											42	30					2.51966e-14	4.0127e-14	0.00361	1	0
ACTN4	81	broad.mit.edu	37	19	39214592	39214592	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:39214592C>T	uc002oja.1	+	14	1626	c.1567C>T	c.(1567-1569)CTG>TTG	p.L523L	ACTN4_uc002ojb.1_5'Flank	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	523					platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AGAGAAGCAGCTGGAGGCCAT	0.617	Colon(168;199 1940 10254 46213 46384)		NA											20	23					0	0	0.008871	0	0
PSMC4	5704	broad.mit.edu	37	19	40480540	40480540	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:40480540G>C	uc002omq.2	+	5	616	c.579G>C	c.(577-579)CAG>CAC	p.Q193H	PSMC4_uc002omr.2_Missense_Mutation_p.Q162H	NM_006503	NP_006494	P43686	PRS6B_HUMAN	proteasome 26S ATPase subunit 4 isoform 1	193					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			ovary(1)	1	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TCTACAAGCAGGTGAGGCGGT	0.612	Colon(105;1478 1543 4034 6132 38638)		NA											39	31					0	0	0.005524	0	0
ZNF780B	163131	broad.mit.edu	37	19	40554637	40554637	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:40554637C>A	uc002omu.2	-	3	141	c.76G>T	c.(76-78)GAT>TAT	p.D26Y	ZNF780B_uc002omv.2_5'UTR	NM_001005851	NP_001005851	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	26	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					GTCCTCTGATCAGGCTGCAGG	0.468			NA											114	125					1.6696e-61	3.19006e-61	0.00361	1	0
PSG8	440533	broad.mit.edu	37	19	43268342	43268342	+	Silent	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:43268342A>C	uc002ouo.2	-	2	254	c.156T>G	c.(154-156)CTT>CTG	p.L52L	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc002oui.2_Intron|PSG8_uc002ouh.2_Silent_p.L52L|PSG8_uc010ein.2_Intron|PSG8_uc002ouj.3_5'UTR|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Silent_p.L52L|PSG8_uc002oum.3_Silent_p.L52L|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Silent_p.L52L	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	52	Ig-like V-type.					extracellular region					0		Prostate(69;0.00899)				GGACAAGTAGAAGAACATCCT	0.463			NA											25	342					0	0	0.00333	0	0
ZNF283	284349	broad.mit.edu	37	19	44351434	44351434	+	Silent	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:44351434A>G	uc002oxr.3	+	7	949	c.681A>G	c.(679-681)AGA>AGG	p.R227R	ZNF283_uc002oxp.3_Silent_p.R88R	NM_181845	NP_862828	Q8N7M2	ZN283_HUMAN	zinc finger protein 283	227	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				AACATGAGAGAACTCATACAG	0.363			NA											5	136					0	0	0.000602	0	0
DMWD	1762	broad.mit.edu	37	19	46287940	46287940	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:46287940C>T	uc002pdj.1	-	4	1982	c.1936G>A	c.(1936-1938)GAA>AAA	p.E646K	DMPK_uc002pdf.1_5'Flank|DMPK_uc002pdg.1_5'Flank|DMPK_uc002pdh.1_5'Flank|DMPK_uc002pdi.1_5'Flank|DMPK_uc010xxt.1_5'Flank|DMWD_uc002pdk.1_Intron|DMWD_uc010eko.1_Missense_Mutation_p.E331K	NM_004943	NP_004934	Q09019	DMWD_HUMAN	dystrophia myotonica-containing WD repeat motif	646					meiosis						0		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		caacttccttcccctgtctgg	0.303			NA											35	118					0	0	0.005524	0	0
DACT3	147906	broad.mit.edu	37	19	47151918	47151918	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:47151918C>A	uc010ekq.2	-	4	1785	c.1711G>T	c.(1711-1713)GGT>TGT	p.G571C		NM_145056	NP_659493	Q96B18	DACT3_HUMAN	thymus expressed gene 3-like	571											0		Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000173)|all cancers(93;0.000464)|Epithelial(262;0.02)|GBM - Glioblastoma multiforme(486;0.0325)		ACGAGGCCACCGCTGCCGTCT	0.716			NA											28	54					9.80776e-20	1.68195e-19	0.00632	1	0
PRKD2	25865	broad.mit.edu	37	19	47195022	47195022	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:47195022C>A	uc002pfh.2	-	13	2014	c.1672G>T	c.(1672-1674)GGC>TGC	p.G558C	PRKD2_uc002pfd.2_5'Flank|PRKD2_uc010eks.2_5'Flank|PRKD2_uc010ekt.2_5'UTR|PRKD2_uc002pfe.2_Missense_Mutation_p.G78C|PRKD2_uc002pff.2_Missense_Mutation_p.G78C|PRKD2_uc002pfg.2_Missense_Mutation_p.G401C|PRKD2_uc002pfi.2_Missense_Mutation_p.G558C|PRKD2_uc002pfj.2_Missense_Mutation_p.G558C|PRKD2_uc010xye.1_Missense_Mutation_p.G558C|PRKD2_uc002pfk.2_Missense_Mutation_p.G401C	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	558	ATP (By similarity).|Protein kinase.				cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		TGCCCTGAGCCCAGCACTTCG	0.592			NA											18	76					1.9806e-07	2.58924e-07	0.002299	1	0
GPR77	27202	broad.mit.edu	37	19	47844849	47844849	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:47844849C>A	uc010ela.1	+	2	1011	c.793C>A	c.(793-795)CTC>ATC	p.L265I	GPR77_uc002pgk.1_Missense_Mutation_p.L265I	NM_018485	NP_060955	Q9P296	C5ARL_HUMAN	G protein-coupled receptor 77	265	Extracellular (Potential).				chemotaxis	integral to membrane|plasma membrane	C5a anaphylatoxin receptor activity			ovary(1)	1		all_cancers(25;1.72e-06)|all_lung(116;2.15e-05)|all_epithelial(76;3.44e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.0652)|Ovarian(192;0.086)		all cancers(93;0.000129)|OV - Ovarian serous cystadenocarcinoma(262;0.000415)|Epithelial(262;0.0109)|GBM - Glioblastoma multiforme(486;0.0138)		GAACTCCGCACTCCTGGCCAG	0.652			NA											20	50					4.35082e-09	6.08561e-09	0.010504	1	0
PPP1R15A	23645	broad.mit.edu	37	19	49376588	49376588	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:49376588G>T	uc002pky.3	+	2	367	c.98G>T	c.(97-99)TGG>TTG	p.W33L		NM_014330	NP_055145	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	33	Required for localization in the endoplasmic reticulum.				apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			lung(1)	1		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		AGCCGCGCCTGGAGCCGCCTG	0.647			NA											10	26					0.000978159	0.00108999	0.000978	1	0
ZNF534	147658	broad.mit.edu	37	19	52942160	52942160	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:52942160C>T	uc002pzk.2	+	4	1547	c.1486C>T	c.(1486-1488)CGA>TGA	p.R496*	ZNF534_uc002pzj.1_Intron|ZNF534_uc010epo.1_Intron|ZNF534_uc002pzl.2_Nonsense_Mutation_p.R483*	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	496	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAACCTTCAACGACATAGGAA	0.398			NA											5	13					0	0	0.000602	0	0
VN1R2	317701	broad.mit.edu	37	19	53761993	53761993	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:53761993G>T	uc002qbi.2	+	1	449	c.365G>T	c.(364-366)AGA>ATA	p.R122I		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	122	Extracellular (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0				GBM - Glioblastoma multiforme(134;0.00301)		TACAAGCCAAGATCCACAGAT	0.368			NA											25	60					3.7963e-18	6.43867e-18	0.00333	1	0
NLRP12	91662	broad.mit.edu	37	19	54314336	54314336	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:54314336G>A	uc002qch.3	-	3	797	c.577C>T	c.(577-579)CCC>TCC	p.P193S	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.P193S|NLRP12_uc002qcj.3_Missense_Mutation_p.P193S|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.P193S	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	193					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		ATCTTGATGGGGCTAGCCTGG	0.642			NA											6	72					0	0	0.001168	0	0
CACNG6	59285	broad.mit.edu	37	19	54502988	54502988	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:54502988C>A	uc002qct.2	+	3	1097	c.507C>A	c.(505-507)TTC>TTA	p.F169L	CACNG6_uc002qcu.2_Intron|CACNG6_uc002qcv.2_Intron	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	169	Helical; (Potential).					voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		GTGCAGAGTTCCTGCTCCGAG	0.582			NA											68	137					8.73484e-25	1.56415e-24	0.00361	1	0
LILRA2	11027	broad.mit.edu	37	19	55098788	55098788	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:55098788G>T	uc002qgg.3	+	8	1516	c.1427G>T	c.(1426-1428)AGC>ATC	p.S476I	LILRA2_uc010ern.2_3'UTR|LILRA2_uc002qgf.2_Missense_Mutation_p.S459I|LILRA2_uc010ero.2_Missense_Mutation_p.S447I|LILRA2_uc010yfg.1_Intron	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	476	Cytoplasmic (Potential).				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		AGCCAGAGAAGCCTACAAGAT	0.567			NA											19	26					2.35188e-11	3.51982e-11	0.006122	1	0
KIR2DL1	3802	broad.mit.edu	37	19	55282321	55282321	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:55282321G>T	uc002qhb.1	+	2	93	c.55G>T	c.(55-57)GCC>TCC	p.A19S	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL3_uc010erw.1_Intron|KIR2DL1_uc002qgz.1_Intron|KIR2DL3_uc002qha.1_Intron|KIR3DP1_uc010yfi.1_Intron|KIR2DL1_uc010erz.1_Missense_Mutation_p.A19S	NM_014218	NP_055033	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two	19					immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		GCTGCAGGGGGCCTGGCCACA	0.562	GBM(72;624 1217 3963 34152 38303)		NA											73	116					2.01602e-52	3.84718e-52	0.00361	1	0
KIR2DL4	3805	broad.mit.edu	37	19	55325168	55325168	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:55325168C>A	uc010yfm.1	+	9	875	c.835C>A	c.(835-837)CCT>ACT	p.P279T	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL4_uc010yfl.1_Missense_Mutation_p.P296T|KIR2DL4_uc002qhg.2_Missense_Mutation_p.P244T|KIR2DL4_uc002qhi.2_3'UTR|KIR2DL4_uc002qhh.2_Missense_Mutation_p.P149T|KIR2DL4_uc002qhj.2_Missense_Mutation_p.P227T|KIR2DL4_uc002qhf.2_Missense_Mutation_p.P132T|KIR2DL4_uc010esd.2_Intron|KIR2DL4_uc010ese.2_RNA|KIR3DL1_uc010yfn.1_5'Flank|KIR3DL1_uc010esf.2_5'Flank|KIR3DL1_uc002qhk.3_5'Flank|KIR3DL1_uc010yfo.1_5'Flank|KIR3DL1_uc002qhl.3_5'Flank	NM_002255	NP_002246	Q99706	KI2L4_HUMAN	killer cell immunoglobulin-like receptor, two	279	Cytoplasmic (Potential).		Missing (in allele KIR2DL4*0501).		cellular defense response|regulation of immune response	integral to plasma membrane	protein binding|transmembrane receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0192)		GAACCAAGAGCCTGCGGGACA	0.493			NA											31	43					9.73076e-26	1.75678e-25	0.006999	1	0
KIR3DL1	3811	broad.mit.edu	37	19	55331374	55331374	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:55331374G>T	uc002qhk.3	+	4	625	c.562G>T	c.(562-564)GCC>TCC	p.A188S	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Missense_Mutation_p.A130S|KIR3DL1_uc010esf.2_Missense_Mutation_p.A93S|KIR3DL1_uc010yfo.1_Missense_Mutation_p.A130S|KIR3DL1_uc002qhl.3_Missense_Mutation_p.A188S	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	188	Extracellular (Potential).|Ig-like C2-type 2.				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		CATGATGCTTGCCCTTGCAGG	0.552			NA											119	273					7.7863e-71	1.48955e-70	0.00361	1	0
C19orf51	352909	broad.mit.edu	37	19	55670618	55670618	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:55670618C>A	uc002qji.1	-	12	1472	c.1438G>T	c.(1438-1440)GCC>TCC	p.A480S	TNNI3_uc002qjg.3_5'Flank|TNNI3_uc010yft.1_5'Flank|C19orf51_uc002qjh.1_Missense_Mutation_p.A295S|C19orf51_uc002qjj.1_Missense_Mutation_p.A527S|C19orf51_uc002qjk.1_Missense_Mutation_p.A426S|C19orf51_uc002qjl.1_Missense_Mutation_p.A547S			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	480											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		AGAGGCTGGGCCAGGATGTCA	0.632			NA											7	21					5.4927e-09	7.63426e-09	0.004482	1	0
NLRP4	147945	broad.mit.edu	37	19	56370569	56370569	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:56370569T>C	uc002qmd.3	+	3	2232	c.1810T>C	c.(1810-1812)TTT>CTT	p.F604L	NLRP4_uc002qmf.2_Missense_Mutation_p.F529L|NLRP4_uc010etf.2_Missense_Mutation_p.F435L	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	604							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GAAACTCTGTTTTTCCGTTCA	0.408			NA											17	67					0	0	0.006122	0	0
NLRP13	126204	broad.mit.edu	37	19	56424587	56424587	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:56424587T>A	uc010ygg.1	-	5	621	c.596A>T	c.(595-597)AAA>ATA	p.K199I		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	199							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TACGTGGTCTTTAGGCCAACT	0.483			NA											64	125					0	0	0.00361	0	0
AURKC	6795	broad.mit.edu	37	19	57744004	57744004	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:57744004G>A	uc002qoe.2	+	4	580	c.391G>A	c.(391-393)GAG>AAG	p.E131K	AURKC_uc002qoc.2_Missense_Mutation_p.E112K|AURKC_uc002qod.2_Missense_Mutation_p.E97K|AURKC_uc010etv.2_Missense_Mutation_p.E128K	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	131	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		GCTCTACAAGGAGCTGCAGAA	0.537			NA											6	66					0	0	0.001168	0	0
ZNF587	84914	broad.mit.edu	37	19	58370797	58370797	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:58370797C>T	uc002qql.2	+	3	1155	c.1017C>T	c.(1015-1017)CTC>CTT	p.L339L	ZNF587_uc002qqb.2_Silent_p.L296L|ZNF587_uc010yhh.1_Silent_p.L296L|ZNF587_uc002qqi.1_Silent_p.L296L|ZNF587_uc002qqj.1_RNA|ZNF814_uc002qqk.2_Intron|ZNF587_uc010yhk.1_Silent_p.L338L	NM_032828	NP_116217	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	339	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		AGGGTAACCTCATTCAACATC	0.453	Pancreas(59;641 1233 1885 20055 50741)		NA											63	144					0	0	0.00361	0	0
ZNF814	730051	broad.mit.edu	37	19	58384403	58384403	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:58384403G>A	uc002qqo.2	-	3	2627	c.2355C>T	c.(2353-2355)TCC>TCT	p.S785S	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	785	C2H2-type 21.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						TTGTGAAACTGGAGCTTTCAG	0.408			NA											11	23					0	0	0.000978	0	0
TPO	7173	broad.mit.edu	37	2	1459997	1459997	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:1459997G>T	uc002qww.2	+	7	853	c.762G>T	c.(760-762)GGG>GGT	p.G254G	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Silent_p.G254G|TPO_uc002qwr.2_Silent_p.G254G|TPO_uc002qwx.2_Silent_p.G254G|TPO_uc010yio.1_Silent_p.G254G|TPO_uc010yip.1_Silent_p.G254G	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	254	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CTGCCTTCGGGGGAGGGGCTG	0.473			NA											5	30					1.23904e-05	1.49305e-05	0.000602	1	0
TSSC1	7260	broad.mit.edu	37	2	3341795	3341795	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:3341795G>A	uc002qxj.2	-	3	445	c.252C>T	c.(250-252)TAC>TAT	p.Y84Y		NM_003310	NP_003301	Q53HC9	TSSC1_HUMAN	tumor suppressing subtransferable candidate 1	84							protein binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.212)		OV - Ovarian serous cystadenocarcinoma(76;0.00877)|Epithelial(75;0.0283)|all cancers(51;0.0464)		TACTTCTGTTGTAGCAGGTCG	0.443	Colon(140;1261 1762 4183 34270 49743)		NA											10	108					0	0	0.008291	0	0
ADI1	55256	broad.mit.edu	37	2	3504654	3504654	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:3504654G>A	uc002qxp.3	-	3	443	c.351C>T	c.(349-351)ATC>ATT	p.I117I	ADI1_uc010yiq.1_RNA	NM_018269	NP_060739	Q9BV57	MTND_HUMAN	acireductone dioxygenase 1	117					L-methionine salvage from methylthioadenosine	cytoplasm|nucleus|plasma membrane	acireductone dioxygenase (Ni2+-requiring) activity|metal ion binding|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0729)|Epithelial(75;0.173)|all cancers(51;0.228)		TCTCCATGAAGATCCGGATCC	0.582			NA											7	39					0	0	0.006214	0	0
NOL10	79954	broad.mit.edu	37	2	10729817	10729817	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:10729817G>A	uc002raq.2	-	18	1608	c.1483C>T	c.(1483-1485)CAA>TAA	p.Q495*	NOL10_uc010yje.1_Nonsense_Mutation_p.Q469*|NOL10_uc010yjf.1_Nonsense_Mutation_p.Q445*|NOL10_uc002rap.2_Nonsense_Mutation_p.Q445*	NM_024894	NP_079170	Q9BSC4	NOL10_HUMAN	nucleolar protein 10	495						nucleolus					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.207)		TCATCTACTTGGAAGTCAGGG	0.328			NA											4	9					0	0	0.009096	0	0
NBAS	51594	broad.mit.edu	37	2	15615813	15615813	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:15615813C>A	uc002rcc.1	-	14	1365	c.1339G>T	c.(1339-1341)GAG>TAG	p.E447*	NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	447										ovary(2)|liver(1)|skin(1)	4						AGCCTTACCTCCAAACTTAAA	0.318			NA											4	26					0.00909568	0.00983662	0.009096	1	0
FAM49A	81553	broad.mit.edu	37	2	16745340	16745340	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:16745340A>G	uc010exm.1	-	4	363	c.215T>C	c.(214-216)ATT>ACT	p.I72T	FAM49A_uc002rck.1_Missense_Mutation_p.I72T	NM_030797	NP_110424	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	72						intracellular					0	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			TTGAAGCTGAATGTCATTGGG	0.378			NA											5	45					0	0	0.000602	0	0
APOB	338	broad.mit.edu	37	2	21246498	21246498	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:21246498C>G	uc002red.2	-	17	2631	c.2503G>C	c.(2503-2505)GCC>CCC	p.A835P		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	835					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AGTTCAAAGGCATTCTCCATG	0.448			NA											9	40					0	0	0.004482	0	0
UBXN2A	165324	broad.mit.edu	37	2	24205850	24205850	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:24205850G>T	uc010exy.2	+	6	840	c.372G>T	c.(370-372)TTG>TTT	p.L124F	UBXN2A_uc002rem.2_RNA|UBXN2A_uc002ren.2_Missense_Mutation_p.L124F|UBXN2A_uc010ykj.1_Missense_Mutation_p.L124F	NM_181713	NP_859064	P68543	UBX2A_HUMAN	UBX domain containing 4	124	SEP.										0						AAATATGTTTGTCTACGAAGC	0.373			NA											10	67					0.00621372	0.00674832	0.006214	1	0
PPM1G	5496	broad.mit.edu	37	2	27607565	27607565	+	Missense_Mutation	SNP	G	G	A	rs150808424		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:27607565G>A	uc002rkl.2	-	6	907	c.800C>T	c.(799-801)GCG>GTG	p.A267V	PPM1G_uc002rkm.2_Missense_Mutation_p.A48V	NM_002707	NP_002698	O15355	PPM1G_HUMAN	protein phosphatase 1G	267	Asp/Glu-rich (acidic).|Poly-Glu.				cell cycle arrest|protein dephosphorylation	cytoplasm|nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					TTCTTCCTCCGCCTCATCTGA	0.537			NA											20	145					0	0	0.008871	0	0
GPN1	11321	broad.mit.edu	37	2	27857779	27857779	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:27857779C>A	uc010ymc.1	+	6	480	c.459C>A	c.(457-459)ATC>ATA	p.I153I	ZNF512_uc010yly.1_RNA|GPN1_uc010ezf.2_Silent_p.I127I|GPN1_uc010yma.1_Silent_p.I60I|GPN1_uc010ymb.1_Silent_p.I44I|GPN1_uc010ymd.1_Silent_p.I34I|GPN1_uc010yme.1_Silent_p.I153I|GPN1_uc010ezg.1_Silent_p.I34I	NM_007266	NP_009197	Q9HCN4	GPN1_HUMAN	GPN-loop GTPase 1 isoform a	139						cytoplasm	GTP binding|nucleoside-triphosphatase activity|protein binding				0						GGACAATTATCACTGAAGCCC	0.403			NA											14	55					1.49906e-05	1.79654e-05	0.00245	1	0
ALK	238	broad.mit.edu	37	2	29446262	29446262	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:29446262G>A	uc002rmy.2	-	20	4212	c.3305C>T	c.(3304-3306)ACC>ATC	p.T1102I	ALK_uc010ymo.1_Missense_Mutation_p.T34I	NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	1102	Cytoplasmic (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GATGGAGGAGGTCTTGCCAGC	0.587			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				9	48					0	0	0.006214	0	0
ALK	238	broad.mit.edu	37	2	29519836	29519836	+	Silent	SNP	T	T	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:29519836T>G	uc002rmy.2	-	9	2642	c.1735A>C	c.(1735-1737)AGG>CGG	p.R579R		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	579	MAM 2.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CAGACCATCCTGCCTTGCTCC	0.567			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				11	35					0	0	0.000978	0	0
LTBP1	4052	broad.mit.edu	37	2	33567972	33567972	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:33567972C>A	uc002ros.2	+	25	3801	c.3801C>A	c.(3799-3801)TCC>TCA	p.S1267S	LTBP1_uc002rot.2_Silent_p.S941S|LTBP1_uc002rou.2_Silent_p.S940S|LTBP1_uc002rov.2_Silent_p.S887S|LTBP1_uc010ymz.1_Intron|LTBP1_uc010yna.1_Intron|LTBP1_uc010ynb.1_Intron	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1266	EGF-like 13; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CAGCTGGCTCCTTCCGCTGCC	0.448			NA											10	48					2.17888e-05	2.60114e-05	0.006214	1	0
SLC8A1	6546	broad.mit.edu	37	2	40655707	40655707	+	Missense_Mutation	SNP	C	C	A	rs151189284		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:40655707C>A	uc002rrx.2	-	1	1738	c.1714G>T	c.(1714-1716)GTT>TTT	p.V572F	SLC8A1_uc002rry.2_Missense_Mutation_p.V572F|SLC8A1_uc002rrz.2_Missense_Mutation_p.V572F|SLC8A1_uc002rsa.2_Missense_Mutation_p.V572F|SLC8A1_uc002rsd.3_Missense_Mutation_p.V572F|SLC8A1_uc002rsb.1_Missense_Mutation_p.V572F|SLC8A1_uc010fan.1_Missense_Mutation_p.V572F|SLC8A1_uc002rsc.1_Missense_Mutation_p.V572F	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	572	Calx-beta 2.|Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TTATATGGAACGATAACATTT	0.438			NA											28	110					7.38237e-10	1.05855e-09	0.00632	1	0
SLC8A1	6546	broad.mit.edu	37	2	40656124	40656124	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:40656124C>A	uc002rrx.2	-	1	1321	c.1297G>T	c.(1297-1299)GGT>TGT	p.G433C	SLC8A1_uc002rry.2_Missense_Mutation_p.G433C|SLC8A1_uc002rrz.2_Missense_Mutation_p.G433C|SLC8A1_uc002rsa.2_Missense_Mutation_p.G433C|SLC8A1_uc002rsd.3_Missense_Mutation_p.G433C|SLC8A1_uc002rsb.1_Missense_Mutation_p.G433C|SLC8A1_uc010fan.1_Missense_Mutation_p.G433C|SLC8A1_uc002rsc.1_Missense_Mutation_p.G433C	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	433	Calx-beta 1.|Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	AAATCACCACCTCTGCGGATA	0.433			NA											16	69					8.00594e-06	9.79281e-06	0.007413	1	0
LHCGR	3973	broad.mit.edu	37	2	48925784	48925784	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:48925784C>A	uc002rwu.3	-	9	906	c.836G>T	c.(835-837)TGC>TTC	p.C279F	GTF2A1L_uc002rwt.2_Intron|LHCGR_uc002rwv.2_RNA	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	279	Extracellular (Potential).				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	AAAAGCACAGCAGTGGCTGGG	0.413			NA							Familial_Male-Limited_Precocious_Puberty				9	67					1.12685e-05	1.36427e-05	0.004482	1	0
NRXN1	9378	broad.mit.edu	37	2	50463973	50463973	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:50463973C>A	uc010fbp.2	-	2	1202	c.395G>T	c.(394-396)CGA>CTA	p.R132L	NRXN1_uc002rxb.3_Missense_Mutation_p.R839L|NRXN1_uc010fbq.2_Missense_Mutation_p.R1207L|NRXN1_uc002rxe.3_Missense_Mutation_p.R1167L|NRXN1_uc002rxc.1_RNA	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	132	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACTGTCCACTCGCACCAATAC	0.423			NA											15	37					7.07596e-05	8.27409e-05	0.006122	1	0
PAPOLG	64895	broad.mit.edu	37	2	61010339	61010339	+	Silent	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:61010339A>G	uc002sai.2	+	13	1392	c.1161A>G	c.(1159-1161)CTA>CTG	p.L387L	PAPOLG_uc002saj.2_Silent_p.L76L|PAPOLG_uc002sak.2_5'UTR|PAPOLG_uc010fch.2_Silent_p.L76L	NM_022894	NP_075045	Q9BWT3	PAPOG_HUMAN	poly(A) polymerase gamma	387					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(2;0.0797)		LUSC - Lung squamous cell carcinoma(5;1.19e-07)|Lung(5;2.86e-06)|Epithelial(17;0.0768)			AAAACCATCTAGAGTGGTAAG	0.333	GBM(183;1497 2932 21839 46797)		NA											19	68					0	0	0.001882	0	0
USP34	9736	broad.mit.edu	37	2	61605508	61605508	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:61605508C>G	uc002sbe.2	-	8	1088	c.1066G>C	c.(1066-1068)GAC>CAC	p.D356H		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	356					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			GTTTCTGTGTCCGATACTAAT	0.249			NA											7	62					0	0	0.001984	0	0
FAM161A	84140	broad.mit.edu	37	2	62066780	62066780	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:62066780C>A	uc010ypo.1	-	3	1461	c.1359G>T	c.(1357-1359)GTG>GTT	p.V453V	FAM161A_uc002sbm.3_Silent_p.V453V|FAM161A_uc002sbn.3_Silent_p.V263V|FAM161A_uc010fcm.1_RNA|FAM161A_uc010fcn.1_Silent_p.V344V	NM_032180	NP_115556	Q3B820	F161A_HUMAN	hypothetical protein LOC84140	453					response to stimulus|visual perception	centrosome				large_intestine(2)|ovary(1)	3						ATGGTTTACACACTGTTAAGA	0.383			NA											17	56					4.7546e-09	6.62633e-09	0.004007	1	0
BMP10	27302	broad.mit.edu	37	2	69093692	69093692	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:69093692G>T	uc002sez.1	-	2	505	c.346C>A	c.(346-348)CAG>AAG	p.Q116K		NM_014482	NP_055297	O95393	BMP10_HUMAN	bone morphogenetic protein 10 preproprotein	116					activin receptor signaling pathway|adult heart development|atrial cardiac muscle tissue morphogenesis|BMP signaling pathway|cardiac muscle cell proliferation|heart trabecula formation|negative regulation of cardiac muscle hypertrophy|negative regulation of cell growth|negative regulation of endothelial cell migration|Notch signaling pathway|pathway-restricted SMAD protein phosphorylation|positive regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle hypertrophy|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent|sarcomere organization|ventricular cardiac muscle cell development|ventricular cardiac muscle tissue morphogenesis	cell surface|extracellular space|Z disc	cytokine activity|growth factor activity|receptor serine/threonine kinase binding			ovary(2)	2						CTGACCGGCTGGGAAAACAGA	0.428			NA											10	35					0.000442599	0.000499343	0.006214	1	0
DYSF	8291	broad.mit.edu	37	2	71744159	71744159	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:71744159G>T	uc002sie.2	+	9	1272	c.896G>T	c.(895-897)GGG>GTG	p.G299V	DYSF_uc010feg.2_Missense_Mutation_p.G330V|DYSF_uc010feh.2_Missense_Mutation_p.G299V|DYSF_uc002sig.3_Missense_Mutation_p.G299V|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.G299V|DYSF_uc010fef.2_Missense_Mutation_p.G330V|DYSF_uc010fei.2_Missense_Mutation_p.G330V|DYSF_uc010fek.2_Missense_Mutation_p.G331V|DYSF_uc010fej.2_Missense_Mutation_p.G300V|DYSF_uc010fel.2_Missense_Mutation_p.G300V|DYSF_uc010feo.2_Missense_Mutation_p.G331V|DYSF_uc010fem.2_Missense_Mutation_p.G300V|DYSF_uc010fen.2_Missense_Mutation_p.G331V|DYSF_uc002sif.2_Missense_Mutation_p.G300V	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	299	Cytoplasmic (Potential).|C2 2.		G -> R (in LGMD2B and proximodistal myopathy).|G -> E (in MMD1).|G -> W (in MMD1).			cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						GCTCTCCTCGGGGAGTTCCGG	0.527			NA											10	73					3.86212e-05	4.5402e-05	0.008291	1	0
TTC31	64427	broad.mit.edu	37	2	74720290	74720290	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:74720290C>T	uc002slt.2	+	13	1528	c.1505C>T	c.(1504-1506)TCA>TTA	p.S502L	TTC31_uc010yrv.1_Nonsense_Mutation_p.Q161*|TTC31_uc002slu.2_Missense_Mutation_p.S356L	NM_022492	NP_071937	Q49AM3	TTC31_HUMAN	tetratricopeptide repeat domain 31	502							binding				0						CAGGACCCTTCAAAGGGCTGG	0.587			NA											17	58					0	0	0.004007	0	0
LRRTM4	80059	broad.mit.edu	37	2	77745707	77745707	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:77745707C>A	uc002snr.2	-	3	1703	c.1288G>T	c.(1288-1290)GTG>TTG	p.V430L	LRRTM4_uc002snq.2_Missense_Mutation_p.V430L|LRRTM4_uc002sns.2_Missense_Mutation_p.V430L|LRRTM4_uc002snt.2_Missense_Mutation_p.V431L	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	430	Helical; (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		AAGAGAGCCACACTCCCGGCA	0.478			NA											21	56					2.37509e-13	3.70207e-13	0.010504	1	0
LRRTM1	347730	broad.mit.edu	37	2	80530201	80530201	+	Silent	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:80530201C>G	uc002sok.1	-	2	1014	c.744G>C	c.(742-744)GTG>GTC	p.V248V	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	248	LRR 7.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GCGAGCTGACCACAATGGCCA	0.592			NA								HNSCC(69;0.2)			19	56					0	0	0.006122	0	0
CTNNA2	1496	broad.mit.edu	37	2	80646707	80646707	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:80646707A>C	uc010ysh.1	+	8	1276	c.1271A>C	c.(1270-1272)CAT>CCT	p.H424P	CTNNA2_uc010yse.1_Missense_Mutation_p.H424P|CTNNA2_uc010ysf.1_Missense_Mutation_p.H424P|CTNNA2_uc010ysg.1_Missense_Mutation_p.H424P|CTNNA2_uc010ysi.1_Missense_Mutation_p.H56P	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	424					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						TTCCGTGAGCATGCCAACAAA	0.443			NA											10	70					0	0	0.001368	0	0
CTNNA2	1496	broad.mit.edu	37	2	80773070	80773070	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:80773070G>T	uc010ysh.1	+	10	1427	c.1422G>T	c.(1420-1422)CAG>CAT	p.Q474H	CTNNA2_uc010yse.1_Missense_Mutation_p.Q474H|CTNNA2_uc010ysf.1_Missense_Mutation_p.Q474H|CTNNA2_uc010ysg.1_Missense_Mutation_p.Q474H|CTNNA2_uc010ysi.1_Missense_Mutation_p.Q106H	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	474					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						CCCGGCCACAGAGCAAAGTTG	0.517			NA											7	32					0.00198382	0.00218689	0.001984	1	0
CTNNA2	1496	broad.mit.edu	37	2	80874769	80874769	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:80874769C>A	uc010ysh.1	+	18	2639	c.2634C>A	c.(2632-2634)CTC>CTA	p.L878L	CTNNA2_uc010yse.1_Silent_p.L830L|CTNNA2_uc010ysf.1_Silent_p.L830L|CTNNA2_uc010ysg.1_Silent_p.L785L|CTNNA2_uc010ysi.1_Silent_p.L462L|CTNNA2_uc010ysj.1_Silent_p.L159L	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	878					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						CTGTTGTCCTCACGGTGAAAG	0.478			NA											26	144					7.38237e-10	1.05855e-09	0.00632	1	0
TGOLN2	10618	broad.mit.edu	37	2	85554096	85554096	+	Silent	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:85554096A>C	uc010fgd.1	-	2	1048	c.759T>G	c.(757-759)GTT>GTG	p.V253V	TGOLN2_uc002soz.2_Silent_p.V253V|TGOLN2_uc002spa.2_Intron|TGOLN2_uc002spb.2_Intron|TGOLN2_uc002spc.1_Silent_p.V253V	NM_006464	NP_006455	O43493	TGON2_HUMAN	trans-golgi network protein 2	253	Extracellular (Potential).					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding				0						GCTGCTCTGGAACCACCTTGT	0.567			NA											15	139					0	0	0.003163	0	0
SMYD1	150572	broad.mit.edu	37	2	88390656	88390656	+	Silent	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:88390656T>C	uc002ssr.2	+	4	656	c.654T>C	c.(652-654)AAT>AAC	p.N218N	SMYD1_uc002ssq.1_Intron|SMYD1_uc002sss.2_5'UTR	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	218	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						TATTTAACAATGGCAAGTGAG	0.512			NA											15	128					0	0	0.004007	0	0
SMYD1	150572	broad.mit.edu	37	2	88409967	88409967	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:88409967C>A	uc002ssr.2	+	10	1411	c.1409C>A	c.(1408-1410)CCC>CAC	p.P470H	SMYD1_uc002ssq.1_Intron|SMYD1_uc002sss.2_Missense_Mutation_p.P166H	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	470					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						AACAACCAGCCCATGCAGGTC	0.602			NA											5	11					5.9392e-07	7.59035e-07	0.001168	1	0
C2orf51	200523	broad.mit.edu	37	2	88828655	88828655	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:88828655C>A	uc002stb.1	+	4	348	c.206C>A	c.(205-207)CCT>CAT	p.P69H		NM_152670	NP_689883	Q96LM6	TSC21_HUMAN	chromosome 2 open reading frame 51	69						nucleus				skin(1)	1						GATGGGTACCCTGCTTTCAAA	0.547			NA											8	67					0.00448238	0.00488872	0.004482	1	0
ZAP70	7535	broad.mit.edu	37	2	98349797	98349797	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:98349797G>T	uc002syd.1	+	7	1035	c.828G>T	c.(826-828)ACG>ACT	p.T276T	ZAP70_uc010yvf.1_Silent_p.T276T|ZAP70_uc002sye.1_Silent_p.T166T|ZAP70_uc002syf.1_5'Flank	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	276	Interdomain B.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						ACCCATCCACGTTGACTCATG	0.697			NA											3	11					0.004672	0.00508113	0.004672	1	0
MAP4K4	9448	broad.mit.edu	37	2	102314937	102314937	+	Silent	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:102314937T>C	uc002tbg.2	+	2	115	c.60T>C	c.(58-60)GAT>GAC	p.D20D	MAP4K4_uc002tbc.2_Silent_p.D20D|MAP4K4_uc002tbd.2_Silent_p.D20D|MAP4K4_uc002tbe.2_Silent_p.D20D|MAP4K4_uc002tbf.2_Silent_p.D20D|MAP4K4_uc010yvy.1_Silent_p.D20D|MAP4K4_uc002tbh.2_Silent_p.D20D|MAP4K4_uc002tbi.2_Silent_p.D20D	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	20					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CTCTCCAGGATCCTGCTGGGA	0.473			NA											8	380					0	0	0.00308	0	0
SLC9A2	6549	broad.mit.edu	37	2	103300762	103300762	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:103300762C>T	uc002tca.2	+	5	1534	c.1392C>T	c.(1390-1392)GCC>GCT	p.A464A		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	464	Helical; Name=M13; (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						TTACGGCTGCCATTGTTGTCA	0.403			NA											50	152					0	0	0.00361	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459973	107459973	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:107459973C>A	uc002tdq.2	-	2	580	c.461G>T	c.(460-462)GGG>GTG	p.G154V	ST6GAL2_uc002tdr.2_Missense_Mutation_p.G154V|ST6GAL2_uc002tds.3_Missense_Mutation_p.G154V	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	154	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						GCCTGGCTCCCCGGGGGAAGG	0.622			NA											88	129					1.55023e-36	2.92927e-36	0.00361	1	0
RGPD4	285190	broad.mit.edu	37	2	108488503	108488503	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:108488503C>G	uc010ywk.1	+	20	4125	c.4043C>G	c.(4042-4044)TCC>TGC	p.S1348C	RGPD4_uc002tdu.2_Missense_Mutation_p.S535C|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1348	RanBD1 2.				intracellular transport		binding			skin(2)	2						GTTGAAGTATCCAGTGGTGAG	0.393			NA											29	362					0	0	0.002836	0	0
ZC3H6	376940	broad.mit.edu	37	2	113069485	113069485	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:113069485G>A	uc002thq.1	+	5	1112	c.718G>A	c.(718-720)GTG>ATG	p.V240M		NM_198581	NP_940983	P61129	ZC3H6_HUMAN	zinc finger CCCH-type domain containing 6	240							nucleic acid binding|zinc ion binding			ovary(3)|central_nervous_system(1)	4						AGGGCCTAATGTGTTTTCAGT	0.383			NA											5	58					0	0	0.000602	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125204404	125204404	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:125204404C>A	uc002tno.2	+	6	1172	c.808C>A	c.(808-810)CAC>AAC	p.H270N	CNTNAP5_uc010flu.2_Missense_Mutation_p.H270N	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	270	Laminin G-like 1.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CCAGCACTGGCACTCGGTCCT	0.607			NA											27	47					7.92952e-12	1.1972e-11	0.003954	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125405454	125405454	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:125405454G>C	uc002tno.2	+	13	2357	c.1993G>C	c.(1993-1995)GAG>CAG	p.E665Q	CNTNAP5_uc010flu.2_Missense_Mutation_p.E666Q	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	665	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GGAACAGCTGGAGGCCGTGAT	0.622			NA											3	12					0	0	0.004672	0	0
BIN1	274	broad.mit.edu	37	2	127808384	127808384	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:127808384C>A	uc002tns.1	-	17	1911	c.1566G>T	c.(1564-1566)ATG>ATT	p.M522I	BIN1_uc010yzf.1_Missense_Mutation_p.M314I|BIN1_uc010yzg.1_Missense_Mutation_p.M399I|BIN1_uc002tnu.1_Missense_Mutation_p.M353I|BIN1_uc002toa.1_Missense_Mutation_p.M411I|BIN1_uc002tnt.1_Missense_Mutation_p.M338I|BIN1_uc002tnv.1_Missense_Mutation_p.M479I|BIN1_uc002tnw.1_Missense_Mutation_p.M426I|BIN1_uc002tnx.1_Missense_Mutation_p.M383I|BIN1_uc002tny.1_Missense_Mutation_p.M435I|BIN1_uc002tnz.1_Missense_Mutation_p.M447I|BIN1_uc002tob.1_Missense_Mutation_p.M368I|BIN1_uc002toc.1_Missense_Mutation_p.M404I	NM_139343	NP_647593	O00499	BIN1_HUMAN	bridging integrator 1 isoform 1	522	SH3.				cell proliferation|endocytosis|interspecies interaction between organisms|multicellular organismal development	actin cytoskeleton|nucleus				ovary(2)|central_nervous_system(2)|skin(2)|lung(1)	7	Colorectal(110;0.0831)			BRCA - Breast invasive adenocarcinoma(221;0.073)		TCACCTTGAACATGAAACCTG	0.502			NA									OREG0014962	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	50	78					9.52127e-25	1.70299e-24	0.00361	1	0
MYO7B	4648	broad.mit.edu	37	2	128351140	128351140	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:128351140A>T	uc002top.2	+	18	2218	c.2165A>T	c.(2164-2166)CAG>CTG	p.Q722L		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	722	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		AAGCTCCGCCAGATGACCCTG	0.617			NA											32	73					0	0	0.003271	0	0
SAP130	79595	broad.mit.edu	37	2	128775444	128775444	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:128775444T>A	uc002tpp.2	-	3	368	c.236A>T	c.(235-237)CAC>CTC	p.H79L	SAP130_uc002tpo.2_5'Flank|SAP130_uc010fmd.2_Missense_Mutation_p.H79L|SAP130_uc002tpq.1_Missense_Mutation_p.H53L	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	79					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		GGAACTCATGTGCTCCCTGGC	0.502			NA											10	54					0	0	0.000978	0	0
POTEF	728378	broad.mit.edu	37	2	130832240	130832240	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:130832240G>T	uc010fmh.2	-	17	3205	c.2805C>A	c.(2803-2805)TCC>TCA	p.S935S		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	935	Actin-like.					cell cortex	ATP binding			skin(3)|ovary(2)	5						TCTTCTCTAGGGAGGAGCTGG	0.622			NA											20	45					0.000229342	0.000262397	0.001882	1	0
FAM123C	205147	broad.mit.edu	37	2	131521368	131521368	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:131521368A>T	uc002trw.2	+	2	1913	c.1723A>T	c.(1723-1725)ACA>TCA	p.T575S	FAM123C_uc010fmv.2_Missense_Mutation_p.T575S|FAM123C_uc010fms.1_Missense_Mutation_p.T575S|FAM123C_uc010fmt.1_Missense_Mutation_p.T575S|FAM123C_uc010fmu.1_Missense_Mutation_p.T575S	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	575										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		CCCGGGCACCACAGGCCTGCT	0.672			NA											19	28					0	0	0.006122	0	0
FAM123C	205147	broad.mit.edu	37	2	131521382	131521382	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:131521382C>A	uc002trw.2	+	2	1927	c.1737C>A	c.(1735-1737)GCC>GCA	p.A579A	FAM123C_uc010fmv.2_Silent_p.A579A|FAM123C_uc010fms.1_Silent_p.A579A|FAM123C_uc010fmt.1_Silent_p.A579A|FAM123C_uc010fmu.1_Silent_p.A579A	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	579										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		GCCTGCTCGCCGGAGAGAGCA	0.662			NA											24	34					2.21704e-12	3.38714e-12	0.00278	1	0
TUBA3D	113457	broad.mit.edu	37	2	132238109	132238109	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:132238109C>A	uc002tsu.3	+	4	950	c.843C>A	c.(841-843)GCC>GCA	p.A281A		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	281					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		CTGAGAAGGCCTACCACGAGC	0.577	Ovarian(137;2059 2432 35543 39401)		NA											71	116					1.77791e-30	3.30675e-30	0.00361	1	0
NCKAP5	344148	broad.mit.edu	37	2	133539711	133539711	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:133539711G>C	uc002ttp.2	-	14	5047	c.4673C>G	c.(4672-4674)CCT>CGT	p.P1558R	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1558							protein binding				0						CTGTAGTTCAGGCTTCTTTTT	0.378			NA											12	160					0	0	0.000978	0	0
CXCR4	7852	broad.mit.edu	37	2	136873041	136873041	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:136873041C>T	uc002tuz.2	-	2	552	c.457G>A	c.(457-459)GAA>AAA	p.E153K	CXCR4_uc002tuy.2_Missense_Mutation_p.E157K|CXCR4_uc010fnk.2_Missense_Mutation_p.E138K	NM_003467	NP_003458	P61073	CXCR4_HUMAN	chemokine (C-X-C motif) receptor 4 isoform b	153	Cytoplasmic.				activation of MAPK activity|apoptosis|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|inflammatory response|initiation of viral infection|regulation of chemotaxis|response to hypoxia|response to virus	cell leading edge|cell surface|cytoplasmic membrane-bounded vesicle|integral to membrane|plasma membrane	actin binding|C-X-C chemokine receptor activity|coreceptor activity|myosin light chain binding|ubiquitin binding|ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.155)	Framycetin(DB00452)	ACCACCTTTTCAGCCAACAGC	0.547			NA											27	110					0	0	0.003954	0	0
LRP1B	53353	broad.mit.edu	37	2	141079550	141079550	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:141079550T>A	uc002tvj.1	-	82	13594	c.12622A>T	c.(12622-12624)AAT>TAT	p.N4208Y		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4208	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTGTCATCATTGCAGGTGCCA	0.363	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			13	123					0	0	0.003163	0	0
LRP1B	53353	broad.mit.edu	37	2	141747099	141747099	+	Splice_Site	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:141747099A>T	uc002tvj.1	-	17	3742	c.2770_splice	c.e17+1	p.A924_splice	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCAAACCTTTACCTGTGCAAG	0.388	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			44	92					0	0	0.00361	0	0
ZEB2	9839	broad.mit.edu	37	2	145156855	145156855	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:145156855G>T	uc002tvu.2	-	8	2379	c.1899C>A	c.(1897-1899)GCC>GCA	p.A633A	ZEB2_uc002tvv.2_Silent_p.A627A|ZEB2_uc010zbm.1_Silent_p.A604A|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Silent_p.A662A	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	633						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		ACAAGAGGAGGGCTTTATTAT	0.428	Melanoma(33;1235 1264 5755 16332)		NA											6	79					3.59834e-05	4.24306e-05	0.001168	1	0
NMI	9111	broad.mit.edu	37	2	152132019	152132019	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:152132019T>C	uc002txi.2	-	6	943	c.613A>G	c.(613-615)ATC>GTC	p.I205V		NM_004688	NP_004679	Q13287	NMI_HUMAN	N-myc and STAT interactor	205					inflammatory response|JAK-STAT cascade|transcription from RNA polymerase II promoter	cytoplasm|nucleus	nucleotide binding|protein binding|transcription cofactor activity				0				BRCA - Breast invasive adenocarcinoma(221;0.0571)		ACAAACGTGATGACTGCACTC	0.468			NA											6	95					0	0	0.001984	0	0
NEB	4703	broad.mit.edu	37	2	152507313	152507313	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:152507313G>T	uc010fnx.2	-	53	7193	c.7002C>A	c.(7000-7002)TCC>TCA	p.S2334S		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2334	Nebulin 62.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTACATTCATGGACAACACAA	0.433			NA											14	366					1.5842e-08	2.18022e-08	0.001855	1	0
GALNT5	11227	broad.mit.edu	37	2	158115854	158115854	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:158115854G>T	uc002tzg.2	+	1	1515	c.1260G>T	c.(1258-1260)ACG>ACT	p.T420T	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	420	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						ACAGTGGAACGCACCAGGTGT	0.493			NA											11	51					9.70103e-10	1.38844e-09	0.008291	1	0
ERMN	57471	broad.mit.edu	37	2	158178131	158178131	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:158178131G>A	uc002tzh.2	-	3	769	c.507C>T	c.(505-507)GAC>GAT	p.D169D	ERMN_uc010zcj.1_Silent_p.D63D|ERMN_uc010zck.1_Silent_p.D149D|ERMN_uc002tzi.2_Silent_p.D182D	NM_020711	NP_065762	Q8TAM6	ERMIN_HUMAN	ermin, ERM-like protein isoform b	169						cytoplasm|cytoskeleton				ovary(1)|skin(1)	2						AATGTAACATGTCAGCTTGGC	0.353			NA											50	121					0	0	0.00361	0	0
PLA2R1	22925	broad.mit.edu	37	2	160798647	160798647	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:160798647G>C	uc002ube.1	-	29	4375	c.4168C>G	c.(4168-4170)CCA>GCA	p.P1390A	PLA2R1_uc010zcp.1_Missense_Mutation_p.P1388A	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	1390	Extracellular (Potential).				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						CCTTTTTCTGGCAGCGCCTCT	0.279			NA											26	45					0	0	0.007291	0	0
SLC4A10	57282	broad.mit.edu	37	2	162821590	162821590	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:162821590G>A	uc002ubx.3	+	23	3250	c.3066G>A	c.(3064-3066)TTG>TTA	p.L1022L	SLC4A10_uc002uby.3_Silent_p.L992L|SLC4A10_uc010zcs.1_Silent_p.L1003L	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	1022	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						TAAGAAAGTTGATGGACTTGT	0.378			NA											5	54					0	0	0.000602	0	0
KCNH7	90134	broad.mit.edu	37	2	163228428	163228428	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:163228428G>A	uc002uch.1	-	16	3714	c.3502C>T	c.(3502-3504)CAT>TAT	p.H1168Y		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	1168	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	AAAGAAGGATGCCTAATTGGA	0.413	GBM(196;1492 2208 17507 24132 45496)		NA											5	58					0	0	0.000602	0	0
SCN2A	6326	broad.mit.edu	37	2	166172032	166172032	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:166172032G>T	uc002udc.2	+	11	1725	c.1435G>T	c.(1435-1437)GGG>TGG	p.G479W	SCN2A_uc002udd.2_Missense_Mutation_p.G479W|SCN2A_uc002ude.2_Missense_Mutation_p.G479W	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	479					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	TGGTGCTGGTGGGATAGGAGT	0.373			NA											9	110					1.76689e-08	2.4016e-08	0.006214	1	0
SCN2A	6326	broad.mit.edu	37	2	166172034	166172034	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:166172034G>T	uc002udc.2	+	11	1727	c.1437G>T	c.(1435-1437)GGG>GGT	p.G479G	SCN2A_uc002udd.2_Silent_p.G479G|SCN2A_uc002ude.2_Silent_p.G479G	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	479					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	GTGCTGGTGGGATAGGAGTTT	0.373			NA											7	114					1.06961e-07	1.40907e-07	0.00308	1	0
XIRP2	129446	broad.mit.edu	37	2	168099305	168099305	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:168099305C>A	uc002udx.2	+	8	1421	c.1403C>A	c.(1402-1404)GCA>GAA	p.A468E	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.A293E|XIRP2_uc010fpq.2_Missense_Mutation_p.A246E|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	293					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GATGTGACAGCATTTTCCCAG	0.428			NA											25	65					4.59853e-10	6.63084e-10	0.005443	1	0
LRP2	4036	broad.mit.edu	37	2	170012818	170012818	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:170012818C>T	uc002ues.2	-	65	12330	c.12117G>A	c.(12115-12117)ATG>ATA	p.M4039I		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4039	EGF-like 15; calcium-binding (Potential).|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GGCGGTCACTCATAGACGTGA	0.433			NA											10	122					0	0	0.008291	0	0
LRP2	4036	broad.mit.edu	37	2	170163811	170163811	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:170163811C>G	uc002ues.2	-	4	620	c.407G>C	c.(406-408)GGA>GCA	p.G136A	LRP2_uc010zdf.1_Missense_Mutation_p.G136A	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	136	Extracellular (Potential).|LDL-receptor class A 3.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTCATCAGCTCCATCGGGGCA	0.448			NA											7	108					0	0	0.001984	0	0
GAD1	2571	broad.mit.edu	37	2	171715317	171715317	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:171715317G>C	uc002ugi.2	+	16	1947	c.1525G>C	c.(1525-1527)GAG>CAG	p.E509Q	GAD1_uc010fqc.2_Missense_Mutation_p.E128Q	NM_000817	NP_000808	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 isoform GAD67	509					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	TCTGCAGCCTGAGCACACAAA	0.443			NA											16	46					0	0	0.006122	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173825890	173825890	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:173825890G>C	uc002uhv.3	+	8	819	c.632G>C	c.(631-633)CGA>CCA	p.R211P	RAPGEF4_uc002uhu.2_Missense_Mutation_p.R211P|RAPGEF4_uc002uhw.3_Missense_Mutation_p.R67P|RAPGEF4_uc010zec.1_Missense_Mutation_p.R58P|RAPGEF4_uc010zed.1_Missense_Mutation_p.R40P|RAPGEF4_uc010zee.1_Missense_Mutation_p.R58P|RAPGEF4_uc010fqo.2_Missense_Mutation_p.R40P|RAPGEF4_uc010zef.1_5'UTR|RAPGEF4_uc010zeg.1_Missense_Mutation_p.R38P|RAPGEF4_uc010fqp.1_5'UTR|RAPGEF4_uc010zeh.1_5'UTR	NM_007023	NP_008954	Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	211					blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)			AAAATTTTACGAAATGCCATT	0.428			NA											8	186					0	0	0.008291	0	0
SCRN3	79634	broad.mit.edu	37	2	175292567	175292567	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:175292567A>G	uc002uiq.2	+	8	1307	c.1219A>G	c.(1219-1221)ACA>GCA	p.T407A	SCRN3_uc010zen.1_Missense_Mutation_p.T400A|SCRN3_uc010zeo.1_Missense_Mutation_p.T205A|SCRN3_uc002uis.2_Missense_Mutation_p.T149A	NM_024583	NP_078859	Q0VDG4	SCRN3_HUMAN	secernin 3	407					proteolysis		dipeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.229)			TCCTCAGTGTACAAAAGATGA	0.333			NA											3	57					0	0	0.004672	0	0
HOXD13	3239	broad.mit.edu	37	2	176958400	176958400	+	Splice_Site	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:176958400G>T	uc002ukf.1	+	1	868	c.781_splice	c.e1+1	p.G261_splice		NM_000523	NP_000514	P35453	HXD13_HUMAN	homeobox D13						skeletal system development|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0526)|READ - Rectum adenocarcinoma(9;0.0678)		TCCTTTCCAGGTAGGGGCGAT	0.567			NA	T	NUP98	AML*								10	39					1.76689e-08	2.4016e-08	0.006214	1	0
TTN	7273	broad.mit.edu	37	2	179398288	179398288	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:179398288G>T	uc010zfg.1	-	307	95574	c.95350C>A	c.(95350-95352)CTA>ATA	p.L31784I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.L25479I|TTN_uc010zfi.1_Missense_Mutation_p.L25412I|TTN_uc010zfj.1_Missense_Mutation_p.L25287I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32711							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTGGGTGTAGGGTTACTGTC	0.433			NA											29	48					1.5548e-18	2.64866e-18	0.005443	1	0
TTN	7273	broad.mit.edu	37	2	179411856	179411856	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:179411856A>T	uc010zfg.1	-	289	86916	c.86692T>A	c.(86692-86694)TGC>AGC	p.C28898S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.C22593S|TTN_uc010zfi.1_Missense_Mutation_p.C22526S|TTN_uc010zfj.1_Missense_Mutation_p.C22401S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29825							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGTAGTTGCACTCTAAGCAT	0.423			NA											45	436					0	0	0.00361	0	0
TTN	7273	broad.mit.edu	37	2	179431857	179431857	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:179431857C>T	uc010zfg.1	-	275	71522	c.71298G>A	c.(71296-71298)TGG>TGA	p.W23766*	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Nonsense_Mutation_p.W17461*|TTN_uc010zfi.1_Nonsense_Mutation_p.W17394*|TTN_uc010zfj.1_Nonsense_Mutation_p.W17269*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24693							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAACAACAGTCCAGGCAAGTC	0.398			NA											75	103					0	0	0.00361	0	0
TTN	7273	broad.mit.edu	37	2	179473146	179473146	+	Silent	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:179473146T>A	uc010zfg.1	-	224	44984	c.44760A>T	c.(44758-44760)CTA>CTT	p.L14920L	uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.L8615L|TTN_uc010zfi.1_Silent_p.L8548L|TTN_uc010zfj.1_Silent_p.L8423L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15847							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCATTTCACTAGCATACTGT	0.388			NA											9	23					0	0	0.004482	0	0
TTN	7273	broad.mit.edu	37	2	179494983	179494983	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:179494983G>T	uc010zfg.1	-	188	36786	c.36562C>A	c.(36562-36564)CAC>AAC	p.H12188N	TTN_uc010zfh.1_Missense_Mutation_p.H5883N|TTN_uc010zfi.1_Missense_Mutation_p.H5816N|TTN_uc010zfj.1_Missense_Mutation_p.H5691N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13115							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTCGGAGGTGGGCACTAGAT	0.388			NA											44	83					4.02871e-13	6.26688e-13	0.00361	1	0
TTN	7273	broad.mit.edu	37	2	179516903	179516903	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:179516903G>T	uc010zfg.1	-	158	32137	c.31913C>A	c.(31912-31914)CCA>CAA	p.P10638Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc010fre.1_Intron|TTN_uc002umw.1_5'Flank|TTN_uc002umx.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11565							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGCACCTCTGGGACTTTAAA	0.408			NA											68	120					2.02627e-32	3.80544e-32	0.00361	1	0
TTN	7273	broad.mit.edu	37	2	179583950	179583950	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:179583950G>T	uc010zfg.1	-	80	20659	c.20435C>A	c.(20434-20436)ACG>AAG	p.T6812K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.T3473K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7739							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCCACACACGTGTATATGCC	0.498			NA											49	55					2.13384e-23	3.79021e-23	0.00361	1	0
TTN	7273	broad.mit.edu	37	2	179602947	179602947	+	Nonsense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:179602947T>A	uc010zfg.1	-	46	10725	c.10501A>T	c.(10501-10503)AAG>TAG	p.K3501*	TTN_uc010zfh.1_Nonsense_Mutation_p.K4574*|TTN_uc010zfi.1_Nonsense_Mutation_p.K4507*|TTN_uc010zfj.1_Nonsense_Mutation_p.K4382*|TTN_uc002umz.1_Nonsense_Mutation_p.K162*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4428							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAGAACACTTGTCACTCTCA	0.468			NA											14	33					0	0	0.003163	0	0
TTN	7273	broad.mit.edu	37	2	179611108	179611108	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:179611108T>C	uc002unb.2	-	46	16243	c.16019A>G	c.(16018-16020)CAT>CGT	p.H5340R	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATACTTTTATGGTCAGGAGT	0.338			NA											22	32					0	0	0.00278	0	0
TTN	7273	broad.mit.edu	37	2	179613326	179613326	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:179613326C>G	uc002unb.2	-	46	14025	c.13801G>C	c.(13801-13803)GCT>CCT	p.A4601P	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTAAAATAAGCTTCTTCTGGT	0.348			NA											31	136					0	0	0.008361	0	0
TTN	7273	broad.mit.edu	37	2	179664422	179664422	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:179664422T>C	uc002und.2	-	6	931	c.706A>G	c.(706-708)ACA>GCA	p.T236A	TTN_uc010zfg.1_Missense_Mutation_p.T236A|TTN_uc010zfh.1_Missense_Mutation_p.T236A|TTN_uc010zfi.1_Missense_Mutation_p.T236A|TTN_uc010zfj.1_Missense_Mutation_p.T236A|TTN_uc002unb.2_Missense_Mutation_p.T236A			Q8WZ42	TITIN_HUMAN	Homo sapiens cDNA FLJ32040 fis, clone NTONG2000858, highly similar to H.sapiens mRNA for titin protein.	236							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTCAACTGTTGCAATTGAT	0.493			NA											14	67					0	0	0.003163	0	0
NUP35	129401	broad.mit.edu	37	2	183993024	183993024	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:183993024C>T	uc002upf.2	+	2	153	c.50C>T	c.(49-51)CCA>CTA	p.P17L	NUP35_uc010zfs.1_5'UTR|NUP35_uc010zft.1_5'UTR|NUP35_uc002upg.2_RNA	NM_138285	NP_612142	Q8NFH5	NUP53_HUMAN	nucleoporin 35kDa	17					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	intermediate filament cytoskeleton|nuclear membrane|nuclear pore|plasma membrane					0						GGATCTGAACCAATGATGCTG	0.388			NA											4	53					0	0	0.000602	0	0
FAM171B	165215	broad.mit.edu	37	2	187626951	187626951	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:187626951C>A	uc002ups.2	+	8	1994	c.1882C>A	c.(1882-1884)CTG>ATG	p.L628M	FAM171B_uc002upr.1_Missense_Mutation_p.L595M|FAM171B_uc002upt.2_Missense_Mutation_p.L97M	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	628	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						AAGCAGCTTACTGGAATCCGT	0.493			NA											40	78					1.03325e-14	1.67318e-14	0.002852	1	0
FAM171B	165215	broad.mit.edu	37	2	187627260	187627260	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:187627260C>A	uc002ups.2	+	8	2303	c.2191C>A	c.(2191-2193)CAT>AAT	p.H731N	FAM171B_uc002upr.1_Missense_Mutation_p.H698N|FAM171B_uc002upt.2_Missense_Mutation_p.H200N	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	731	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						CAAAAGCATGCATCAGCCCAA	0.483			NA											43	92					1.89013e-27	3.44066e-27	0.00361	1	0
CALCRL	10203	broad.mit.edu	37	2	188250312	188250312	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:188250312T>C	uc002upv.3	-	4	559	c.11A>G	c.(10-12)AAG>AGG	p.K4R	CALCRL_uc010frt.2_Missense_Mutation_p.K4R	NM_005795	NP_005786	Q16602	CALRL_HUMAN	calcitonin receptor-like precursor	4						integral to plasma membrane				lung(3)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			CAGGGTACACTTTTTCTCCAT	0.264			NA											3	37					0	0	0.004672	0	0
SGOL2	151246	broad.mit.edu	37	2	201437779	201437779	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:201437779A>T	uc002uvw.2	+	7	2823	c.2710A>T	c.(2710-2712)AAT>TAT	p.N904Y	SGOL2_uc010zhd.1_Missense_Mutation_p.N904Y|SGOL2_uc010zhe.1_Missense_Mutation_p.N904Y	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	904					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						ATCAAAAATAAATAAGCTCAG	0.303			NA											12	195					0	0	0.000978	0	0
ALS2CR4	65062	broad.mit.edu	37	2	202494490	202494490	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:202494490G>A	uc002uyh.1	-	9	740	c.639C>T	c.(637-639)ACC>ACT	p.T213T	ALS2CR4_uc002uyg.1_Silent_p.T205T|ALS2CR4_uc010zho.1_Silent_p.T8T|ALS2CR4_uc010zhp.1_RNA	NM_001044385	NP_001037850	Q96Q45	TM237_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	237						integral to membrane	protein binding				0						CATCTCTGGTGGTCCAGGAAG	0.423			NA											46	66					0	0	0.00361	0	0
CRYGD	1421	broad.mit.edu	37	2	208988977	208988977	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:208988977G>T	uc002vcn.3	-	2	227	c.111C>A	c.(109-111)CGC>CGA	p.R37R		NM_006891	NP_008822	P07320	CRGD_HUMAN	crystallin, gamma D	37	Beta/gamma crystallin 'Greek key' 1.		R -> S (in a patient with cataract; very low solubility; crystallizes spontaneously).		cellular response to reactive oxygen species|visual perception	soluble fraction	protein binding|structural constituent of eye lens				0				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		CGCTGTCCACGCGCGCCGAGT	0.652			NA											7	13					0.00198382	0.00218689	0.001984	1	0
MAP2	4133	broad.mit.edu	37	2	210558918	210558918	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:210558918G>T	uc002vde.1	+	7	2272	c.2024G>T	c.(2023-2025)AGT>ATT	p.S675I	MAP2_uc002vdc.1_Missense_Mutation_p.S675I|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.S671I	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	675					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GACCTCCACAGTAAGAATAAG	0.413	Pancreas(27;423 979 28787 29963)		NA											40	70					4.92203e-23	8.70255e-23	0.00623	1	0
TMEM169	92691	broad.mit.edu	37	2	216964784	216964784	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:216964784C>A	uc010zjr.1	+	4	739	c.413C>A	c.(412-414)TCA>TAA	p.S138*	TMEM169_uc010zjs.1_Nonsense_Mutation_p.S138*|TMEM169_uc002vfw.2_Nonsense_Mutation_p.S138*|TMEM169_uc002vfv.3_Nonsense_Mutation_p.S138*	NM_001142310	NP_001135782	Q96HH4	TM169_HUMAN	transmembrane protein 169	138	Extracellular (Potential).					integral to membrane				ovary(1)	1		Renal(323;0.0651)		Epithelial(149;6.44e-06)|all cancers(144;0.000398)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTAAAGAGTCATCAAGGGAA	0.542			NA											5	87					1.23904e-05	1.49305e-05	0.000602	1	0
CXCR2	3579	broad.mit.edu	37	2	219000010	219000010	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:219000010C>T	uc002vgz.1	+	4	711	c.486C>T	c.(484-486)GTC>GTT	p.V162V	CXCR2_uc002vha.1_Silent_p.V162V|CXCR2_uc002vhb.1_Silent_p.V162V	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	162	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						GCTACTTGGTCAAATTCATAT	0.532			NA											25	42					0	0	0.00278	0	0
VIL1	7429	broad.mit.edu	37	2	219299256	219299256	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:219299256C>A	uc002via.2	+	14	1573	c.1508C>A	c.(1507-1509)ACC>AAC	p.T503N	VIL1_uc010zke.1_Missense_Mutation_p.T192N|VIL1_uc002vib.2_Missense_Mutation_p.T503N	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	503	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAGGGAGGCACCTCCCGAACT	0.602			NA											23	60					8.24728e-16	1.35403e-15	0.004656	1	0
BCS1L	617	broad.mit.edu	37	2	219527605	219527605	+	Splice_Site	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:219527605G>A	uc002vio.2	+	7	1308	c.890_splice	c.e7-1	p.N297_splice	BCS1L_uc002vip.2_Splice_Site_p.N297_splice|BCS1L_uc002viq.2_Splice_Site_p.N297_splice|BCS1L_uc010fvu.2_Splice_Site_p.N297_splice|BCS1L_uc010fvv.2_Splice_Site_p.N297_splice|BCS1L_uc002vir.2_Splice_Site_p.N297_splice|BCS1L_uc002vis.2_Splice_Site_p.N297_splice	NM_004328	NP_004319	Q9Y276	BCS1_HUMAN	BCS1-like						mitochondrial respiratory chain complex I assembly|mitochondrial respiratory chain complex III assembly|mitochondrial respiratory chain complex IV assembly	integral to membrane|mitochondrial respiratory chain complex III	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Renal(207;0.0474)		Epithelial(149;7.12e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTTCCTCCAGACCCAGTAAA	0.517			NA											15	176					0	0	0.004007	0	0
CUL3	8452	broad.mit.edu	37	2	225368392	225368392	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:225368392T>C	uc002vny.2	-	9	1738	c.1354A>G	c.(1354-1356)AAA>GAA	p.K452E	CUL3_uc010zls.1_Missense_Mutation_p.K386E|CUL3_uc010fwy.1_Missense_Mutation_p.K458E	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	452					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		ATCATGTTTTTTTCAGAGTCA	0.318			NA											4	40					0	0	0.000602	0	0
COL4A4	1286	broad.mit.edu	37	2	228004920	228004920	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:228004920C>A	uc010zlt.1	-	4	803	c.149G>T	c.(148-150)AGA>ATA	p.R50I		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	50	7S domain.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		AGAGCAATCTCTTCCTCCACA	0.413			NA											38	72					6.57855e-14	1.03907e-13	0.009718	1	0
TRPM8	79054	broad.mit.edu	37	2	234878910	234878910	+	Missense_Mutation	SNP	C	C	A	rs17862932	byFrequency	TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:234878910C>A	uc002vvh.2	+	17	2235	c.2195C>A	c.(2194-2196)ACC>AAC	p.T732N	TRPM8_uc010fyj.2_Intron	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	732	Extracellular (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	GCGTTCTTCACCTCCCCCTTC	0.527			NA											39	266					2.87052e-16	4.74823e-16	0.005524	1	0
CXCR7	57007	broad.mit.edu	37	2	237489326	237489326	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:237489326A>T	uc010fyq.2	+	3	448	c.218A>T	c.(217-219)AAG>ATG	p.K73M	CXCR7_uc002vwd.2_Missense_Mutation_p.K73M	NM_020311	NP_064707	P25106	CXCR7_HUMAN	chemokine orphan receptor 1	73	Cytoplasmic (Potential).				interspecies interaction between organisms	integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3		Breast(86;0.000182)|Renal(207;0.00339)|all_hematologic(139;0.0048)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|all_lung(227;0.147)|all_neural(83;0.223)		Epithelial(121;8.35e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.09e-11)|Kidney(56;1.11e-07)|KIRC - Kidney renal clear cell carcinoma(57;3.03e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000176)|Lung(119;0.00468)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.118)		ATCCAGGCCAAGACCACAGGC	0.532			NA											17	27					0	0	0.00499	0	0
COL6A3	1293	broad.mit.edu	37	2	238275663	238275663	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:238275663G>T	uc002vwl.2	-	11	5452	c.5167C>A	c.(5167-5169)CTT>ATT	p.L1723I	COL6A3_uc002vwo.2_Missense_Mutation_p.L1517I|COL6A3_uc010znj.1_Missense_Mutation_p.L1116I	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1723	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AGGTGCTCAAGGCCCACCTTA	0.547			NA											7	53					5.18039e-06	6.37205e-06	0.00308	1	0
HDAC4	9759	broad.mit.edu	37	2	239990288	239990288	+	Silent	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:239990288C>G	uc002vyk.3	-	23	3543	c.2751G>C	c.(2749-2751)CCG>CCC	p.P917P	HDAC4_uc010fyy.2_Silent_p.P874P	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	917	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		CGCTGGCGATCGGCATGACCA	0.612			NA											15	51					0	0	0.004007	0	0
OR6B2	389090	broad.mit.edu	37	2	240969557	240969557	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:240969557C>A	uc002vyr.2	-	2	336	c.290G>T	c.(289-291)TGC>TTC	p.C97F	OR6B2_uc010zoc.1_Missense_Mutation_p.C97F	NM_001005853	NP_001005853	Q6IFH4	OR6B2_HUMAN	olfactory receptor, family 6, subfamily B,	97	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.4e-29)|all cancers(36;2.08e-27)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)		CTGCGTCATGCACCCGACGAA	0.587			NA											14	31					1.67942e-08	2.29485e-08	0.006122	1	0
DUSP28	285193	broad.mit.edu	37	2	241500849	241500849	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:241500849G>A	uc002vzg.2	+	2	1127	c.496G>A	c.(496-498)GAG>AAG	p.E166K	ANKMY1_uc002vzd.1_5'Flank|ANKMY1_uc010fze.1_5'Flank|ANKMY1_uc002vze.2_5'Flank|ANKMY1_uc002vzf.2_5'Flank|DUSP28_uc002vzh.2_Missense_Mutation_p.E166K	NM_001033575	NP_001028747	Q4G0W2	DUS28_HUMAN	dual specificity phosphatase 28	166							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-31)|all cancers(36;5.56e-29)|OV - Ovarian serous cystadenocarcinoma(60;7.57e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.06e-06)|Lung(119;0.00164)|Colorectal(34;0.00468)|LUSC - Lung squamous cell carcinoma(224;0.00802)|COAD - Colon adenocarcinoma(134;0.0311)		CCTGCAGGGAGAGCCCCCAGC	0.622	Pancreas(150;1630 2604 23402 46829)		NA											5	31					0	0	0.001168	0	0
SIRPA	140885	broad.mit.edu	37	20	1903195	1903195	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:1903195T>A	uc002wfq.2	+	5	1351	c.991T>A	c.(991-993)TGC>AGC	p.C331S	SIRPA_uc010zps.1_Missense_Mutation_p.C311S|SIRPA_uc002wfr.2_Missense_Mutation_p.C331S|SIRPA_uc002wfs.2_Missense_Mutation_p.C331S|SIRPA_uc002wft.2_Missense_Mutation_p.C331S	NM_001040022	NP_001035111	P78324	SHPS1_HUMAN	signal-regulatory protein alpha precursor	331	Ig-like C1-type 2.|Extracellular (Potential).				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			ovary(1)	1				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		GAAGCTCACCTGCCAGGTGGA	0.572	GBM(155;1668 1920 5945 42733 48121)		NA											8	62					0	0	0.008291	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3673254	3673254	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:3673254G>T	uc002wja.2	-	15	3944	c.3944C>A	c.(3943-3945)ACG>AAG	p.T1315K	SIGLEC1_uc002wjb.1_5'UTR|SIGLEC1_uc002wiz.3_Missense_Mutation_p.T1315K	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	1315	Ig-like C2-type 13.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						ATGAGCCCGCGTGGCCACCAG	0.657			NA											11	40					1.08611e-07	1.42471e-07	0.000978	1	0
C20orf29	55317	broad.mit.edu	37	20	3804637	3804637	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:3804637G>T	uc002wjs.1	+	3	474	c.296G>T	c.(295-297)CGC>CTC	p.R99L	C20orf29_uc002wjt.2_Missense_Mutation_p.R23L|C20orf29_uc002wju.1_Missense_Mutation_p.R99L	NM_018347	NP_060817	Q9NUS5	CT029_HUMAN	hypothetical protein LOC55317	99					double-strand break repair via homologous recombination		protein binding			skin(1)	1						GGGGCTTTCCGCCTGGCAGCA	0.662			NA											10	28					1.76689e-08	2.4016e-08	0.006214	1	0
HAO1	54363	broad.mit.edu	37	20	7875833	7875833	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:7875833C>A	uc002wmw.1	-	5	784	c.760G>T	c.(760-762)GGG>TGG	p.G254W	HAO1_uc010gbu.2_Missense_Mutation_p.G254W	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	254	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						ACCAAGATCCCATTCAAGCCA	0.488			NA											28	104					2.70662e-09	3.8031e-09	0.009535	1	0
PAK7	57144	broad.mit.edu	37	20	9561532	9561532	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:9561532C>A	uc002wnl.2	-	5	795	c.250G>T	c.(250-252)GGC>TGC	p.G84C	PAK7_uc002wnk.2_Missense_Mutation_p.G84C|PAK7_uc002wnj.2_Missense_Mutation_p.G84C|PAK7_uc010gby.1_Missense_Mutation_p.G84C	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	84	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			TCTAGCAGGCCGTTGATGGAG	0.463			NA											45	169					3.77016e-25	6.77485e-25	0.003214	1	0
MKKS	8195	broad.mit.edu	37	20	10393358	10393358	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:10393358C>T	uc002wnt.1	-	3	1692	c.805G>A	c.(805-807)GAA>AAA	p.E269K	MKKS_uc002wnu.1_Missense_Mutation_p.E269K|MKKS_uc010zrd.1_Intron	NM_018848	NP_061336	Q9NPJ1	MKKS_HUMAN	McKusick-Kaufman syndrome protein	269	Substrate-binding apical domain.				brain morphogenesis|cerebral cortex development|convergent extension involved in gastrulation|detection of mechanical stimulus involved in sensory perception of sound|fat cell differentiation|flagellum assembly|gonad development|heart looping|hippocampus development|intracellular transport|melanosome transport|photoreceptor cell maintenance|pigment granule aggregation in cell center|protein folding|regulation of cilium beat frequency involved in ciliary motility|sensory perception of smell|social behavior|spermatid development|striatum development	cytosol|microtubule organizing center|motile cilium	ATP binding|unfolded protein binding				0						ACTGCATTTTCAAGAGAAACC	0.453	Melanoma(79;1979 2212 6640)		NA							Bardet-Biedl_syndrome				7	53					0	0	0.001984	0	0
FLRT3	23767	broad.mit.edu	37	20	14306824	14306824	+	Silent	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:14306824C>G	uc002wov.1	-	3	1796	c.1329G>C	c.(1327-1329)CTG>CTC	p.L443L	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Silent_p.L443L	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	443	Extracellular (Potential).|Fibronectin type-III.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		GGCTATGGCCCAGTTTAAGCC	0.448			NA											25	86					0	0	0.00333	0	0
C20orf26	26074	broad.mit.edu	37	20	20079314	20079314	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:20079314G>C	uc002wru.2	+	8	791	c.715G>C	c.(715-717)GTT>CTT	p.V239L	C20orf26_uc010gcw.1_Missense_Mutation_p.V193L|C20orf26_uc010zse.1_Missense_Mutation_p.V239L|C20orf26_uc010zsf.1_Missense_Mutation_p.V239L	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	239										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		AGGCACAGCTGTTGGGTTCAT	0.338			NA											42	101					0	0	0.003214	0	0
SSTR4	6754	broad.mit.edu	37	20	23017238	23017238	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:23017238C>A	uc002wsr.2	+	1	1182	c.1118C>A	c.(1117-1119)CCA>CAA	p.P373Q		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	373	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GCCCTGCAACCAGAACCCGGC	0.667	Esophageal Squamous(15;850 1104 16640)		NA											9	87					2.74318e-10	3.99669e-10	0.006214	1	0
FRG1B	284802	broad.mit.edu	37	20	29628300	29628300	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:29628300G>A	uc010ztl.1	+	3	244	c.212G>A	c.(211-213)AGT>AAT	p.S71N	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Missense_Mutation_p.S23N					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						GAAGCAAAAAGTAAAACAGCA	0.358			NA											6	52					0	0	0.006214	0	0
CBFA2T2	9139	broad.mit.edu	37	20	32210976	32210976	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:32210976A>T	uc002wzg.1	+	6	1130	c.593A>T	c.(592-594)CAG>CTG	p.Q198L	CBFA2T2_uc010zug.1_5'UTR|CBFA2T2_uc002wze.1_Missense_Mutation_p.Q189L|CBFA2T2_uc002wzf.1_RNA|CBFA2T2_uc002wzh.1_Missense_Mutation_p.Q169L|CBFA2T2_uc002wzi.1_RNA|CBFA2T2_uc002wzj.1_RNA	NM_005093	NP_005084	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit	198	TAFH.					nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)|skin(1)	2						GCGGCCAAGCAGACCCCATCC	0.587	Esophageal Squamous(174;142 1955 14837 21276 28041)		NA											5	70					0	0	0.000602	0	0
EPB41L1	2036	broad.mit.edu	37	20	34797802	34797802	+	Silent	SNP	G	G	T	rs142392996		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:34797802G>T	uc002xfb.2	+	15	2232	c.2061G>T	c.(2059-2061)CCG>CCT	p.P687P	EPB41L1_uc002xeu.2_Silent_p.P613P|EPB41L1_uc010zvo.1_Silent_p.P687P|EPB41L1_uc002xev.2_Silent_p.P687P|EPB41L1_uc002xew.2_Silent_p.P578P|EPB41L1_uc002xex.2_Intron|EPB41L1_uc002xey.2_Intron|EPB41L1_uc002xez.2_Silent_p.P613P|EPB41L1_uc010gfq.2_Silent_p.P786P	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	687					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					GCTCCACCCCGGATATGCCCC	0.657			NA											8	21					0.00448238	0.00488872	0.004482	1	0
RBL1	5933	broad.mit.edu	37	20	35661274	35661274	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:35661274C>T	uc002xgi.2	-	16	2255	c.2176G>A	c.(2176-2178)GCA>ACA	p.A726T	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Missense_Mutation_p.A726T	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	726	Pocket; binds T and E1A.|Spacer.				cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				GCATCATTTGCGACACCTGAA	0.328			NA											33	110					0	0	0.003271	0	0
C20orf132	140699	broad.mit.edu	37	20	35802514	35802514	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:35802514C>T	uc010zvu.1	-	5	384	c.293G>A	c.(292-294)TGT>TAT	p.C98Y	C20orf132_uc002xgm.2_Missense_Mutation_p.C98Y|C20orf132_uc002xgn.2_Missense_Mutation_p.C98Y	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	8											0		Myeloproliferative disorder(115;0.00878)				TTCCTGACTACAGATCCTAGG	0.348			NA											12	29					0	0	0.001368	0	0
LPIN3	64900	broad.mit.edu	37	20	39984671	39984671	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:39984671G>A	uc002xjx.2	+	14	1891	c.1800G>A	c.(1798-1800)CAG>CAA	p.Q600Q	LPIN3_uc010ggh.2_Silent_p.Q601Q|LPIN3_uc010zwf.1_RNA	NM_022896	NP_075047	Q9BQK8	LPIN3_HUMAN	lipin 3	600	C-LIP.				fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(115;0.000739)				CCTCCGATCAGATCGTAAGTG	0.502			NA											6	74					0	0	0.001168	0	0
HNF4A	3172	broad.mit.edu	37	20	43058194	43058194	+	Silent	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:43058194A>T	uc002xma.2	+	10	1403	c.1314A>T	c.(1312-1314)CCA>CCT	p.P438P	HNF4A_uc002xlu.2_Silent_p.P406P|HNF4A_uc002xlv.2_Silent_p.P416P|HNF4A_uc002xlz.2_Silent_p.P428P|HNF4A_uc010ggq.2_Silent_p.P431P	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	438					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CCTCACCGCCAGGTGGCTCAG	0.612	Colon(79;2 1269 8820 14841 52347)		NA											41	116					0	0	0.002522	0	0
RIMS4	140730	broad.mit.edu	37	20	43385559	43385559	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:43385559G>T	uc002xms.2	-	5	571	c.571C>A	c.(571-573)CCC>ACC	p.P191T	RIMS4_uc010ggu.2_Missense_Mutation_p.P192T	NM_182970	NP_892015	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	191	C2.				exocytosis|neurotransmitter transport	cell junction|synapse				ovary(4)|central_nervous_system(1)	5		Myeloproliferative disorder(115;0.0122)				TTGCCCTGGGGACTCTCAGGA	0.567			NA											75	177					5.44642e-36	1.02662e-35	0.00361	1	0
NCOA3	8202	broad.mit.edu	37	20	46281260	46281260	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:46281260G>T	uc002xtk.2	+	21	4262	c.4057G>T	c.(4057-4059)GCT>TCT	p.A1353S	NCOA3_uc002xtl.2_Missense_Mutation_p.A1349S|NCOA3_uc002xtm.2_Missense_Mutation_p.A1348S|NCOA3_uc002xtn.2_Missense_Mutation_p.A1352S|NCOA3_uc010zyc.1_Missense_Mutation_p.A1148S	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	1353					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						ACACCCGCAGGCTGCATCCAT	0.488			NA											20	31					3.99206e-14	6.33138e-14	0.007413	1	0
TSHZ2	128553	broad.mit.edu	37	20	51870809	51870809	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:51870809C>A	uc002xwo.2	+	2	1768	c.812C>A	c.(811-813)GCT>GAT	p.A271D		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	271					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			AAAGAGGATGCTCAAAAGGTT	0.438			NA											13	29					1.49906e-05	1.79654e-05	0.00245	1	0
PCK1	5105	broad.mit.edu	37	20	56138753	56138753	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:56138753G>A	uc002xyn.3	+	6	1094	c.931G>A	c.(931-933)GAC>AAC	p.D311N	PCK1_uc010zzm.1_Intron	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	311		Manganese.			gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CGTCGGGGATGACATTGCCTG	0.557			NA											33	79					0	0	0.002445	0	0
ZBP1	81030	broad.mit.edu	37	20	56191346	56191346	+	Silent	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:56191346A>T	uc002xyo.2	-	2	494	c.213T>A	c.(211-213)ACT>ACA	p.T71T	ZBP1_uc010gjm.2_Silent_p.T71T|ZBP1_uc002xyp.2_Intron|ZBP1_uc010zzn.1_Silent_p.T71T	NM_030776	NP_110403	Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1 isoform a	71	DRADA 1.					cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			ovary(2)	2	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			CTTCAGGATCAGTCCCGCCCA	0.567			NA											9	60					0	0	0.004482	0	0
CDH4	1002	broad.mit.edu	37	20	60348144	60348144	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:60348144C>G	uc002ybn.1	+	4	496	c.482C>G	c.(481-483)GCC>GGC	p.A161G	CDH4_uc002ybp.1_Missense_Mutation_p.A87G	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	161					adherens junction organization|cell junction assembly		calcium ion binding	p.A161T(1)		lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CACCAGAACGCCAACGGGCTG	0.652			NA											5	29					0	0	0.001168	0	0
PRIC285	85441	broad.mit.edu	37	20	62199965	62199965	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:62199965C>A	uc002yfm.2	-	6	2368	c.1476G>T	c.(1474-1476)CAG>CAT	p.Q492H	PRIC285_uc002yfl.1_5'Flank	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	492					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			GCACCACCAGCTGCTCCTCAG	0.672			NA											3	22					0.004672	0.00508113	0.004672	1	0
TPTE	7179	broad.mit.edu	37	21	10941907	10941907	+	Splice_Site	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr21:10941907C>T	uc002yip.1	-	14	1163	c.795_splice	c.e14+1	p.K265_splice	TPTE_uc002yis.1_Splice_Site|TPTE_uc002yiq.1_Splice_Site_p.K247_splice|TPTE_uc002yir.1_Splice_Site_p.K227_splice|TPTE_uc010gkv.1_Splice_Site_p.K127_splice	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAGACCCTTACCTTGATTGGA	0.313			NA											9	192					0	0	0.004482	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19698799	19698799	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr21:19698799C>T	uc002ykw.2	-	16	1902	c.1871G>A	c.(1870-1872)AGA>AAA	p.R624K		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	624	Extracellular (Potential).|CUB 2.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						AAACCCTCCTCTTGCCAACAC	0.453			NA											17	126					0	0	0.008871	0	0
NCAM2	4685	broad.mit.edu	37	21	22881254	22881254	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr21:22881254C>T	uc002yld.1	+	16	2409	c.2160C>T	c.(2158-2160)GAC>GAT	p.D720D	NCAM2_uc011acb.1_Silent_p.D578D	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	720	Cytoplasmic (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		TGGTAACAGACGTCAGCTGCT	0.438			NA											23	60					0	0	0.00278	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28210911	28210911	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr21:28210911C>A	uc002ymf.2	-	8	2506	c.2051G>T	c.(2050-2052)AGC>ATC	p.S684I		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1	684	Cys-rich.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)		GGAATCTGGGCTACATGGAGT	0.408			NA											11	44					3.07112e-06	3.80187e-06	0.000978	1	0
ADAMTS5	11096	broad.mit.edu	37	21	28337778	28337778	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr21:28337778G>C	uc002ymg.2	-	1	1662	c.933C>G	c.(931-933)ATC>ATG	p.I311M		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	311	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						CGGCCAGGCGGATGTGGTTCT	0.592	Esophageal Squamous(53;683 1080 10100 14424 45938)		NA											18	75					0	0	0.007413	0	0
GRIK1	2897	broad.mit.edu	37	21	31023525	31023525	+	Silent	SNP	G	G	A	rs146591187		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr21:31023525G>A	uc002yno.1	-	6	1331	c.867C>T	c.(865-867)CAC>CAT	p.H289H	GRIK1_uc002ynn.2_Silent_p.H289H|GRIK1_uc011acs.1_Silent_p.H289H|GRIK1_uc011act.1_Silent_p.H233H|GRIK1_uc010glq.1_Silent_p.H147H|GRIK1_uc002ynr.2_Silent_p.H289H	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	289	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TGGATGACACGTGAGGGTTGT	0.488			NA											6	58					0	0	0.001984	0	0
KRTAP19-6	337973	broad.mit.edu	37	21	31914007	31914007	+	Missense_Mutation	SNP	C	C	T	rs146590456		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr21:31914007C>T	uc002yok.1	-	1	175	c.146G>A	c.(145-147)CGT>CAT	p.R49H		NM_181612	NP_853643	Q3LI70	KR196_HUMAN	keratin associated protein 19-6	49						intermediate filament					0						ATATCCTTCACGGCATGATGG	0.493			NA											18	191					0	0	0.00499	0	0
KRTAP19-7	337974	broad.mit.edu	37	21	31933543	31933543	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr21:31933543G>A	uc011adb.1	-	1	66	c.66C>T	c.(64-66)GGC>GGT	p.G22G		NM_181614	NP_853645	Q3SYF9	KR197_HUMAN	keratin associated protein 19-7	22						intermediate filament					0						TATAGCCATAGCCCAGGCCAC	0.557			NA											12	112					0	0	0.001855	0	0
KRTAP21-2	337978	broad.mit.edu	37	21	32119316	32119317	+	Missense_Mutation	DNP	CA	CA	TC			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr21:32119316_32119317CA>TC	uc011adh.1	-	1	204_205	c.204_205TG>GA	c.(202-207)TGTGGC>TGGAGC	p.68_69CG>WS		NM_181617	NP_853648	Q3LI59	KR212_HUMAN	keratin associated protein 21-2	68_69						intermediate filament					0						GGTCGGTAGCCACAGCAGCTAG	0.272			NA											13	125					0	0	0.004672	0	0
PRDM15	63977	broad.mit.edu	37	21	43223078	43223078	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr21:43223078C>A	uc002yzq.1	-	30	3946	c.3835G>T	c.(3835-3837)GAG>TAG	p.E1279*	PRDM15_uc002yzo.2_Nonsense_Mutation_p.E950*|PRDM15_uc002yzp.2_Nonsense_Mutation_p.E970*|PRDM15_uc002yzr.1_Nonsense_Mutation_p.E970*	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	1279					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGAGTCAGCTCAGGCTGCAGA	0.592			NA											19	152					9.7654e-05	0.000113243	0.007413	1	0
POFUT2	23275	broad.mit.edu	37	21	46689913	46689913	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr21:46689913C>A	uc002zhc.2	-	7	878	c.853G>T	c.(853-855)GGG>TGG	p.G285W	POFUT2_uc002zha.2_RNA|POFUT2_uc002zhb.2_RNA|POFUT2_uc002zhd.2_Missense_Mutation_p.G285W	NM_133635	NP_598368	Q9Y2G5	OFUT2_HUMAN	protein O-fucosyltransferase 2 isoform C	285					fucose metabolic process	endoplasmic reticulum	peptide-O-fucosyltransferase activity				0				Colorectal(79;0.243)		TAGGGGCCCCCTAGCGCGGAG	0.602			NA											8	48					0.00448238	0.00488872	0.004482	1	0
COL18A1	80781	broad.mit.edu	37	21	46875463	46875463	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr21:46875463G>A	uc011afs.1	+	1	40	c.19G>A	c.(19-21)GGC>AGC	p.G7S	COL18A1_uc002zhg.2_Intron|COL18A1_uc002zhi.2_Missense_Mutation_p.G7S	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	7					cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		CTACCCCTGTGGCTGCCACAT	0.672			NA											7	49					0	0	0.00308	0	0
COL6A1	1291	broad.mit.edu	37	21	47410292	47410292	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr21:47410292G>C	uc002zhu.1	+	13	1060	c.958G>C	c.(958-960)GGA>CGA	p.G320R		NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	320	Triple-helical region.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	CGCCTCACAGGGAGAGAAGGG	0.522			NA											3	57					0	0	0.004672	0	0
LSS	4047	broad.mit.edu	37	21	47611049	47611049	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr21:47611049T>A	uc002zij.2	-	22	2247	c.2168A>T	c.(2167-2169)TAC>TTC	p.Y723F	LSS_uc011afv.1_Missense_Mutation_p.Y712F|LSS_uc002zil.2_Missense_Mutation_p.Y723F|LSS_uc002zik.2_Missense_Mutation_p.Y643F	NM_001001438	NP_001001438	P48449	ERG7_HUMAN	lanosterol synthase isoform 1	723					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity				0	Breast(49;0.214)					TCTCTCAGGGTACAGCTGGGA	0.612	Pancreas(114;955 2313 34923 50507)		NA											7	57					0	0	0.001984	0	0
PCNT	5116	broad.mit.edu	37	21	47768970	47768970	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr21:47768970A>T	uc002zji.3	+	7	1184	c.1077A>T	c.(1075-1077)GAA>GAT	p.E359D	PCNT_uc002zjj.2_Missense_Mutation_p.E241D|PCNT_uc010gqk.1_RNA	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	359	Glu-rich.|Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					TATGTTTAGAAAATCTACGCA	0.328			NA											49	112					0	0	0.00361	0	0
DIP2A	23181	broad.mit.edu	37	21	47977571	47977571	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr21:47977571G>A	uc002zjo.2	+	31	3886	c.3703G>A	c.(3703-3705)GCC>ACC	p.A1235T	DIP2A_uc011afz.1_Missense_Mutation_p.A1231T|DIP2A_uc002zjr.2_Missense_Mutation_p.A202T	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	1235					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		GTGGCTGTCGGCCGTCAGCCA	0.632			NA											9	26					0	0	0.004482	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072298	17072298	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:17072298G>T	uc002zlp.1	-	1	1403	c.1143C>A	c.(1141-1143)ACC>ACA	p.T381T		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	381					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GCCCCTGGGTGGTGGCTCCCC	0.572			NA											16	88					1.02788e-11	1.54584e-11	0.00499	1	0
BID	637	broad.mit.edu	37	22	18226769	18226769	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:18226769C>T	uc002znd.1	-	3	193	c.23G>A	c.(22-24)GGT>GAT	p.G8D	BID_uc002znc.1_Missense_Mutation_p.G54D|BID_uc002zne.1_5'UTR|BID_uc010gra.1_RNA|BID_uc002znf.1_Intron|BID_uc010grb.1_Missense_Mutation_p.G8D|BID_uc010grc.1_Intron	NM_001196	NP_001187	P55957	BID_HUMAN	BH3 interacting domain death agonist isoform 2	8					activation of pro-apoptotic gene products|establishment of protein localization in membrane|induction of apoptosis by intracellular signals|induction of apoptosis via death domain receptors|neuron apoptosis|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria|release of cytochrome c from mitochondria	cytosol|membrane fraction|mitochondrial outer membrane	death receptor binding				0		all_epithelial(15;0.198)		Lung(27;0.0419)		GAGGCTGGAACCGTTGTTGAC	0.587			NA											11	109					0	0	0.001368	0	0
TXNRD2	10587	broad.mit.edu	37	22	19864759	19864759	+	Splice_Site	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:19864759T>A	uc011ahc.1	-	17	1479	c.1446_splice	c.e17-1	p.K482_splice	TXNRD2_uc002zql.1_Splice_Site_p.K236_splice|TXNRD2_uc002zqm.1_Splice_Site|TXNRD2_uc002zqn.1_Splice_Site|TXNRD2_uc002zqo.1_Intron|TXNRD2_uc002zqp.1_Splice_Site|TXNRD2_uc002zqr.1_Intron|TXNRD2_uc002zqj.1_Splice_Site|TXNRD2_uc002zqq.1_Intron	NM_006440	NP_006431	Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2 precursor						cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			ovary(2)	2	Colorectal(54;0.0993)					GCCCCACACCTGCACATGGGG	0.657			NA											6	23					0	0	0.001984	0	0
PI4KA	5297	broad.mit.edu	37	22	21152932	21152932	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:21152932C>A	uc002zsz.3	-	17	2105	c.1874G>T	c.(1873-1875)AGT>ATT	p.S625I	PI4KA_uc010gsq.1_Missense_Mutation_p.S683I	NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	625					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			GGCCTTCACACTGATCTGCTG	0.488	GBM(136;1332 1831 3115 23601 50806)		NA											28	126					6.07407e-21	1.0522e-20	0.007291	1	0
LZTR1	8216	broad.mit.edu	37	22	21343120	21343120	+	Silent	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:21343120T>C	uc002zto.2	+	6	655	c.552T>C	c.(550-552)AGT>AGC	p.S184S	LZTR1_uc002ztn.2_Silent_p.S143S|LZTR1_uc011ahy.1_Silent_p.S165S|LZTR1_uc010gsr.1_Silent_p.S55S	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	184	Kelch 2.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			CGGTGTACAGTGACAAGCTGT	0.652			NA											7	129					0	0	0.006214	0	0
ZNF280A	129025	broad.mit.edu	37	22	22868570	22868570	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:22868570G>A	uc002zwe.2	-	2	1638	c.1385C>T	c.(1384-1386)ACG>ATG	p.T462M	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	462	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		CTCCTTCAACGTCAAAAACTG	0.423			NA											11	139					0	0	0.008291	0	0
TMEM211	255349	broad.mit.edu	37	22	25334188	25334188	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:25334188A>G	uc003abk.1	-	2	80	c.55T>C	c.(55-57)TGG>CGG	p.W19R		NM_001001663	NP_001001663	Q6ICI0	TM211_HUMAN	transmembrane protein 211	90						integral to membrane					0						GCCACAGCCCAAGACAGGAGG	0.552			NA											17	62					0	0	0.007413	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688935	26688935	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:26688935G>T	uc003acb.2	+	2	814	c.658G>T	c.(658-660)GAA>TAA	p.E220*	SEZ6L_uc003acc.2_Nonsense_Mutation_p.E220*|SEZ6L_uc011akc.1_Nonsense_Mutation_p.E220*|SEZ6L_uc003acd.2_Nonsense_Mutation_p.E220*|SEZ6L_uc011akd.1_Nonsense_Mutation_p.E220*|SEZ6L_uc003ace.2_Nonsense_Mutation_p.E220*|SEZ6L_uc003acf.1_5'UTR|SEZ6L_uc010gvc.1_5'UTR	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	220	Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						CCAGAGGCCAGAACCCGGGGA	0.647			NA											16	62					6.49762e-13	1.00164e-12	0.006122	1	0
TFIP11	24144	broad.mit.edu	37	22	26902740	26902740	+	Splice_Site	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:26902740C>T	uc003acr.2	-	4	737	c.363_splice	c.e4+1	p.T121_splice	TFIP11_uc003acs.2_Splice_Site_p.T121_splice|TFIP11_uc003act.2_Splice_Site_p.T121_splice	NM_012143	NP_036275	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11						biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity				0						ATAGAGACTACCGTTTTTAGC	0.458			NA											15	78					0	0	0.00499	0	0
CRYBB1	1414	broad.mit.edu	37	22	27012132	27012132	+	Missense_Mutation	SNP	G	G	C	rs144920095	byFrequency	TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:27012132G>C	uc003acy.1	-	2	222	c.152C>G	c.(151-153)GCG>GGG	p.A51G		NM_001887	NP_001878	P53674	CRBB1_HUMAN	crystallin, beta B1	51	N-terminal arm.				visual perception		structural constituent of eye lens			ovary(1)	1						CAGTTCCGCCGCCTTGGCGCT	0.577			NA											14	47					0	0	0.003163	0	0
PES1	23481	broad.mit.edu	37	22	30974931	30974931	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:30974931G>A	uc003aij.1	-	14	1650	c.1576C>T	c.(1576-1578)CAG>TAG	p.Q526*	PES1_uc003aik.1_Nonsense_Mutation_p.Q521*|PES1_uc003ail.1_Nonsense_Mutation_p.Q509*|PES1_uc003aim.1_Nonsense_Mutation_p.Q525*|PES1_uc003ain.1_Nonsense_Mutation_p.Q387*|PES1_uc003aio.1_Nonsense_Mutation_p.Q387*	NM_014303	NP_055118	O00541	PESC_HUMAN	pescadillo homolog 1, containing BRCT domain	526	Glu-rich.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell cycle	chromosome|nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						TCCTCCTCCTGGGCCAGCCGC	0.567			NA											5	50					0	0	0.001984	0	0
MORC2	22880	broad.mit.edu	37	22	31342403	31342403	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:31342403C>A	uc003aje.1	-	7	1529	c.165G>T	c.(163-165)CTG>CTT	p.L55L		NM_014941	NP_055756	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	117							ATP binding|zinc ion binding			ovary(1)|pancreas(1)	2						TCTTGGTGAACAGGATAAAAT	0.463			NA											44	172					3.86236e-30	7.14908e-30	0.00361	1	0
PLA2G3	50487	broad.mit.edu	37	22	31533819	31533819	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:31533819G>C	uc003aka.2	-	4	1072	c.943C>G	c.(943-945)CAG>GAG	p.Q315E		NM_015715	NP_056530	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III precursor	315					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity				0						GACCCTTTCTGATGTGGTGGC	0.672			NA											12	201					0	0	0.00245	0	0
HMOX1	3162	broad.mit.edu	37	22	35789515	35789515	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:35789515A>T	uc003ant.1	+	5	871	c.791A>T	c.(790-792)CAG>CTG	p.Q264L		NM_002133	NP_002124	P09601	HMOX1_HUMAN	heme oxygenase (decyclizing) 1	264					angiogenesis|anti-apoptosis|cell death|cellular iron ion homeostasis|endothelial cell proliferation|erythrocyte homeostasis|heme catabolic process|heme oxidation|intracellular protein kinase cascade|low-density lipoprotein particle clearance|negative regulation of leukocyte migration|negative regulation of smooth muscle cell proliferation|positive regulation of chemokine biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of smooth muscle cell proliferation|protein homooligomerization|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hydrogen peroxide|response to nicotine|smooth muscle hyperplasia|transmembrane transport|wound healing involved in inflammatory response	endoplasmic reticulum membrane|extracellular space|microsome	enzyme binding|heme binding|heme oxygenase (decyclizing) activity|protein homodimerization activity|signal transducer activity			ovary(1)	1					NADH(DB00157)	ACCCGCTCCCAGGCTCCGCTT	0.582			NA											45	171					0	0	0.009718	0	0
TRIOBP	11078	broad.mit.edu	37	22	38121726	38121726	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:38121726G>T	uc003atr.2	+	7	3434	c.3163G>T	c.(3163-3165)GAG>TAG	p.E1055*	TRIOBP_uc003atu.2_Nonsense_Mutation_p.E883*|TRIOBP_uc003atq.1_Nonsense_Mutation_p.E1055*|TRIOBP_uc003ats.1_Nonsense_Mutation_p.E883*	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	1055					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					GCCCCACCACGAGCCTCCCTA	0.662			NA											20	92					1.55795e-14	2.50181e-14	0.001882	1	0
APOBEC3B	9582	broad.mit.edu	37	22	39385550	39385550	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:39385550G>T	uc003awo.1	+	5	712	c.658G>T	c.(658-660)GTG>TTG	p.V220L	APOBEC3A_uc011aoc.1_Intron|APOBEC3B_uc003awp.1_Missense_Mutation_p.V220L|APOBEC3B_uc003awq.1_Intron|APOBEC3D_uc011aod.1_Intron|APOBEC3D_uc011aoe.1_Intron|APOBEC3D_uc011aof.1_Intron	NM_004900	NP_004891	Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	220					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(58;0.04)					GTGCTATGAGGTGGAGCGCCT	0.547			NA											10	68					0.000442599	0.000499343	0.006214	1	0
TAB1	10454	broad.mit.edu	37	22	39822857	39822857	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:39822857C>A	uc003axt.2	+	9	1120	c.1071C>A	c.(1069-1071)GAC>GAA	p.D357E	TAB1_uc003axr.2_Missense_Mutation_p.D433E|TAB1_uc011aok.1_Missense_Mutation_p.D191E|TAB1_uc003axu.1_Missense_Mutation_p.D357E	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	357	PP2C-like.				activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1						GGCACGAGGACATGACCCTGC	0.662			NA											13	118					1.05317e-09	1.50035e-09	0.00245	1	0
GRAP2	9402	broad.mit.edu	37	22	40367056	40367056	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:40367056C>G	uc003ayh.1	+	8	1224	c.961C>G	c.(961-963)CCT>GCT	p.P321A	GRAP2_uc003ayi.2_RNA|GRAP2_uc011aom.1_Missense_Mutation_p.P295A|GRAP2_uc011aon.1_Missense_Mutation_p.P255A|GRAP2_uc010gya.1_Missense_Mutation_p.P321A|GRAP2_uc011aoo.1_Missense_Mutation_p.P249A|GRAP2_uc011aop.1_Missense_Mutation_p.P281A|GRAP2_uc011aoq.1_Missense_Mutation_p.P208A|GRAP2_uc003ayj.1_Missense_Mutation_p.P321A	NM_004810	NP_004801	O75791	GRAP2_HUMAN	GRB2-related adaptor protein 2	321	SH3 2.				cell-cell signaling|Ras protein signal transduction|T cell costimulation|T cell receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GGGCCTCTTCCCTGCCAACTA	0.587			NA											14	93					0	0	0.004007	0	0
FAM83F	113828	broad.mit.edu	37	22	40417379	40417379	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:40417379C>T	uc003ayk.1	+	4	959	c.865C>T	c.(865-867)CGG>TGG	p.R289W		NM_138435	NP_612444	Q8NEG4	FA83F_HUMAN	hypothetical protein LOC113828	289										breast(1)	1						CACGGAGTTCCGGGAGCTGTA	0.602			NA											16	216					0	0	0.006122	0	0
MKL1	57591	broad.mit.edu	37	22	40814545	40814545	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:40814545C>G	uc003ayv.1	-	9	2104	c.1897G>C	c.(1897-1899)GAG>CAG	p.E633Q	MKL1_uc003ayw.1_Missense_Mutation_p.E633Q|MKL1_uc010gye.1_Missense_Mutation_p.E633Q|MKL1_uc010gyf.1_Missense_Mutation_p.E583Q	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	633	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GGGACCGGCTCGGGCTCAGGC	0.697			NA	T	RBM15	acute megakaryocytic leukemia								4	49					0	0	0.009096	0	0
RANGAP1	5905	broad.mit.edu	37	22	41645438	41645438	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:41645438C>A	uc003azs.2	-	14	3060	c.1590G>T	c.(1588-1590)AAG>AAT	p.K530N	RANGAP1_uc003azt.2_Missense_Mutation_p.K530N|RANGAP1_uc003azu.2_Missense_Mutation_p.K530N|RANGAP1_uc003azr.2_Missense_Mutation_p.K43N|RANGAP1_uc010gyk.2_Missense_Mutation_p.K33N|RANGAP1_uc011aoz.1_Missense_Mutation_p.K475N	NM_002883	NP_002874	P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	530					mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity				0						TGGCAATGGCCTTGACCTTGT	0.597			NA											8	41					0.000157383	0.000180738	0.00308	1	0
ZC3H7B	23264	broad.mit.edu	37	22	41745200	41745200	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:41745200G>T	uc003azw.2	+	16	2059	c.1843G>T	c.(1843-1845)GAC>TAC	p.D615Y	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	631					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						CTTCCAGTTCGACGTGTGCCG	0.647			NA											14	98					3.32936e-07	4.27981e-07	0.006122	1	0
SULT4A1	25830	broad.mit.edu	37	22	44237718	44237718	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:44237718G>T	uc003bee.1	-	2	380	c.264C>A	c.(262-264)GTC>GTA	p.V88V	SULT4A1_uc003bed.1_Silent_p.V9V|SULT4A1_uc003bef.1_RNA|SULT4A1_uc011aqb.1_Intron	NM_014351	NP_055166	Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	88					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity				0		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		GGTACTCCAGGACCGGGAGCT	0.602			NA											20	81					1.40151e-16	2.33332e-16	0.010504	1	0
SULT4A1	25830	broad.mit.edu	37	22	44237804	44237804	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:44237804A>T	uc003bee.1	-	2	294	c.178T>A	c.(178-180)TTG>ATG	p.L60M	SULT4A1_uc003bed.1_Translation_Start_Site|SULT4A1_uc003bef.1_RNA|SULT4A1_uc011aqb.1_Intron	NM_014351	NP_055166	Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	60					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity				0		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		TCCTGCAGCAAGCTGGTGCCT	0.667			NA											8	42					0	0	0.004482	0	0
FBLN1	2192	broad.mit.edu	37	22	45996263	45996263	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:45996263G>T	uc003bgj.1	+	17	2196	c.2049G>T	c.(2047-2049)GGG>GGT	p.G683G	FBLN1_uc003bgk.1_RNA	NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	683					interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		ATGTGGTCGGGGGCGTGGTCT	0.612			NA											15	323					6.31663e-08	8.3931e-08	0.003163	1	0
PKDREJ	10343	broad.mit.edu	37	22	46655703	46655703	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:46655703G>C	uc003bhh.2	-	1	3517	c.3517C>G	c.(3517-3519)CGG>GGG	p.R1173G		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1173	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		ATGTTTAACCGTAGATCCACA	0.493			NA											55	180					0	0	0.00361	0	0
FAM19A5	25817	broad.mit.edu	37	22	49103622	49103622	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:49103622G>T	uc003bim.3	+	3	473	c.356G>T	c.(355-357)TGC>TTC	p.C119F	FAM19A5_uc003bio.3_Missense_Mutation_p.C112F	NM_001082967	NP_001076436	Q7Z5A7	F19A5_HUMAN	family with sequence similarity 19 (chemokine	119						extracellular region|integral to membrane				large_intestine(1)	1		all_cancers(38;2.95e-11)|all_epithelial(38;3.07e-10)|all_lung(38;2.89e-05)|Breast(42;0.000396)|Lung NSC(38;0.000471)|Ovarian(80;0.00934)|Lung SC(80;0.195)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0227)|BRCA - Breast invasive adenocarcinoma(115;0.119)		GGCTGGACGTGCACGCAGCCC	0.612			NA											30	137					2.81731e-10	4.10082e-10	0.002096	1	0
PLXNB2	23654	broad.mit.edu	37	22	50719226	50719226	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:50719226G>A	uc003bkv.3	-	24	4046	c.3940C>T	c.(3940-3942)CAG>TAG	p.Q1314*	PLXNB2_uc003bkt.1_Nonsense_Mutation_p.Q106*|PLXNB2_uc003bku.1_Nonsense_Mutation_p.Q299*	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1314	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TAGAGGGCCTGCTCCACCACC	0.657			NA											5	31					0	0	0.001168	0	0
CHL1	10752	broad.mit.edu	37	3	369946	369946	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:369946G>T	uc003bou.2	+	5	565	c.294G>T	c.(292-294)GGG>GGT	p.G98G	CHL1_uc003bot.2_Silent_p.G98G|CHL1_uc003bow.1_Silent_p.G98G|CHL1_uc011asi.1_Silent_p.G98G	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	98	Ig-like C2-type 1.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CAAACGAGGGGCACATATCTC	0.393			NA											10	116					1.58986e-06	2.00195e-06	0.008291	1	0
BHLHE40	8553	broad.mit.edu	37	3	5025075	5025075	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:5025075G>T	uc003bqf.2	+	5	1244	c.937G>T	c.(937-939)GGC>TGC	p.G313C	BHLHE40_uc011asw.1_Missense_Mutation_p.G173C	NM_003670	NP_003661	O14503	BHE40_HUMAN	basic helix-loop-helix family, member e40	313						Golgi apparatus|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCCGTTCCTGGGCCCACACCC	0.572			NA											9	65					7.48243e-07	9.50738e-07	0.006214	1	0
GRM7	2917	broad.mit.edu	37	3	7621006	7621006	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:7621006A>G	uc003bqm.2	+	8	2687	c.2413A>G	c.(2413-2415)ATT>GTT	p.I805V	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.I805V|GRM7_uc003bql.2_Missense_Mutation_p.I805V|GRM7_uc003bqn.1_Missense_Mutation_p.I388V|GRM7_uc010hch.1_Missense_Mutation_p.I316V	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	805	Helical; Name=6; (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	GCTTGCCTTCATTCCAATTTT	0.383			NA											4	39					0	0	0.000602	0	0
ARPC4	10093	broad.mit.edu	37	3	9839447	9839447	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:9839447G>A	uc003bsz.1	+	2	687	c.108G>A	c.(106-108)CCG>CCA	p.P36P	ARPC4_uc003bta.1_5'UTR|ARPC4_uc003btb.1_5'UTR|ARPC4_uc003btc.1_5'UTR|TTLL3_uc003btd.3_5'UTR	NM_005718	NP_005709	P59998	ARPC4_HUMAN	actin related protein 2/3 complex subunit 4	36					actin filament polymerization|actin nucleation	Arp2/3 protein complex|cell projection|cytoplasm	actin binding				0	Medulloblastoma(99;0.227)					ACAACAAGCCGGAAGTGGAAG	0.582			NA											5	39					0	0	0.000602	0	0
TATDN2	9797	broad.mit.edu	37	3	10291003	10291003	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:10291003A>T	uc003bvg.2	+	2	700	c.119A>T	c.(118-120)CAG>CTG	p.Q40L	TATDN2_uc003bvf.2_Missense_Mutation_p.Q40L|TATDN2_uc011atr.1_Missense_Mutation_p.Q40L|TATDN2_uc011ats.1_RNA|TATDN2_uc011att.1_RNA	NM_014760	NP_055575	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	40						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			pancreas(2)	2						CGGCCAGCTCAGAGGTCTGCG	0.662			NA											19	80					0	0	0.010504	0	0
TMEM40	55287	broad.mit.edu	37	3	12777078	12777078	+	Missense_Mutation	SNP	G	G	A	rs147042676		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:12777078G>A	uc003bxg.1	-	11	785	c.658C>T	c.(658-660)CTC>TTC	p.L220F	TMEM40_uc003bxh.1_Missense_Mutation_p.L190F|TMEM40_uc003bxi.1_Missense_Mutation_p.L144F|TMEM40_uc011auv.1_Missense_Mutation_p.L236F	NM_018306	NP_060776	Q8WWA1	TMM40_HUMAN	transmembrane protein 40	220						integral to membrane					0						TTCTGGAAGAGGGGGATGAAG	0.463			NA											10	82					0	0	0.000978	0	0
FGD5	152273	broad.mit.edu	37	3	14861919	14861919	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:14861919G>T	uc003bzc.2	+	1	1451	c.1341G>T	c.(1339-1341)CAG>CAT	p.Q447H	FGD5_uc011avk.1_Missense_Mutation_p.Q447H	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	447					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						AAGGAGGGCAGGCTGCATCGG	0.627			NA											15	23					1.99824e-07	2.59686e-07	0.00499	1	0
BTD	686	broad.mit.edu	37	3	15686657	15686657	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:15686657A>G	uc003cah.2	+	4	1397	c.1294A>G	c.(1294-1296)ACC>GCC	p.T432A	BTD_uc011avv.1_Missense_Mutation_p.T434A|BTD_uc011avw.1_Missense_Mutation_p.T434A|BTD_uc011avx.1_Missense_Mutation_p.T412A	NM_000060	NP_000051	P43251	BTD_HUMAN	biotinidase precursor	432					central nervous system development|epidermis development|nitrogen compound metabolic process	extracellular space	biotin carboxylase activity|biotinidase activity				0						CGAGAGGCCCACCTTATCCAA	0.517			NA											13	118					0	0	0.00245	0	0
ZNF385D	79750	broad.mit.edu	37	3	21606120	21606120	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:21606120G>A	uc003cce.2	-	3	630	c.222C>T	c.(220-222)CAC>CAT	p.H74H	ZNF385D_uc010hfb.1_RNA	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	74						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GCTTTCTTCGGTGGGGAAGAG	0.318			NA											22	69					0	0	0.00278	0	0
OXSM	54995	broad.mit.edu	37	3	25832986	25832986	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:25832986G>T	uc003cdn.2	+	2	582	c.475G>T	c.(475-477)GTT>TTT	p.V159F	NGLY1_uc011awo.1_5'Flank|OXSM_uc011awp.1_Intron|OXSM_uc010hfh.2_Missense_Mutation_p.V159F	NM_017897	NP_060367	Q9NWU1	OXSM_HUMAN	3-oxoacyl-ACP synthase, mitochondrial isoform 1	159					acyl-CoA metabolic process|medium-chain fatty acid biosynthetic process|short-chain fatty acid biosynthetic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity			ovary(1)|breast(1)	2						TCCTCTTGAAGTTGTTTCTGA	0.428			NA											9	120					7.48243e-07	9.50738e-07	0.006214	1	0
ARPP21	10777	broad.mit.edu	37	3	35724358	35724358	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:35724358A>C	uc003cgb.2	+	4	412	c.148A>C	c.(148-150)AAT>CAT	p.N50H	ARPP21_uc003cga.2_Missense_Mutation_p.N50H|ARPP21_uc011axy.1_Missense_Mutation_p.N50H|ARPP21_uc003cfz.2_RNA|ARPP21_uc003cgc.2_Missense_Mutation_p.N50H|ARPP21_uc003cgd.2_Missense_Mutation_p.N50H|ARPP21_uc011axx.1_RNA|ARPP21_uc003cge.2_Missense_Mutation_p.N50H	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	50	Potential.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						GGAGGCTCAGAATCAAGAAAG	0.289			NA											23	59					0	0	0.00333	0	0
ARPP21	10777	broad.mit.edu	37	3	35778812	35778812	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:35778812C>A	uc003cgb.2	+	16	1866	c.1602C>A	c.(1600-1602)GTC>GTA	p.V534V	ARPP21_uc003cga.2_Silent_p.V480V|ARPP21_uc011axy.1_Silent_p.V500V|ARPP21_uc003cgf.2_Silent_p.V335V|ARPP21_uc003cgg.2_Silent_p.V22V	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	534	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						AACAGCAGGTCCAGCCACCGC	0.647			NA											9	29					0.00829132	0.00899833	0.008291	1	0
C3orf35	339883	broad.mit.edu	37	3	37458935	37458935	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:37458935G>T	uc003cha.3	+	5	842	c.178G>T	c.(178-180)GGC>TGC	p.G60C	C3orf35_uc003chb.2_Missense_Mutation_p.G60C	NM_178339	NP_848029	Q8IVJ8	APRG1_HUMAN	AP20 region protein isoform B	60						integral to membrane				central_nervous_system(1)	1						GGGCCTGCAGGGCAGTGCTCA	0.463			NA											13	52					6.31663e-08	8.3931e-08	0.003163	1	0
SCN10A	6336	broad.mit.edu	37	3	38768446	38768446	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:38768446G>T	uc003ciq.2	-	16	2738	c.2738C>A	c.(2737-2739)GCC>GAC	p.A913D		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	913					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CCGTGCCAGGGCCACCTGCAG	0.582			NA											31	99					1.22384e-17	2.06883e-17	0.002836	1	0
SCN10A	6336	broad.mit.edu	37	3	38781150	38781150	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:38781150C>A	uc003ciq.2	-	14	2136	c.2136G>T	c.(2134-2136)ATG>ATT	p.M712I		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	712	Helical; Name=S2 of repeat II; (Potential).|II.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TTTTGAAGACCATTTCAGCAG	0.433			NA											9	31					1.76689e-08	2.4016e-08	0.006214	1	0
SCN11A	11280	broad.mit.edu	37	3	38888221	38888221	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:38888221G>C	uc011ays.1	-	26	5539	c.5340C>G	c.(5338-5340)AGC>AGG	p.S1780R		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1780					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CCACCCCAAAGCTAGACAAGT	0.468			NA											13	70					0	0	0.001368	0	0
SCN11A	11280	broad.mit.edu	37	3	38888709	38888709	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:38888709A>C	uc011ays.1	-	26	5051	c.4852T>G	c.(4852-4854)TTG>GTG	p.L1618V		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1618					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TCTTCACCCAAAGGGTCCTCA	0.373			NA											25	108					0	0	0.007291	0	0
SCN11A	11280	broad.mit.edu	37	3	38888711	38888711	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:38888711G>A	uc011ays.1	-	26	5049	c.4850C>T	c.(4849-4851)CCT>CTT	p.P1617L		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1617					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TTCACCCAAAGGGTCCTCACT	0.368			NA											26	104					0	0	0.007291	0	0
TTC21A	199223	broad.mit.edu	37	3	39170265	39170265	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:39170265G>T	uc003cjc.2	+	14	1936	c.1759G>T	c.(1759-1761)GAC>TAC	p.D587Y	TTC21A_uc003cje.2_Missense_Mutation_p.D588Y|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Missense_Mutation_p.D539Y	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	587	TPR 8.						binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		CAAGGCTGGAGACTATCCAGA	0.552			NA											45	118					2.56662e-36	4.84386e-36	0.003214	1	0
XIRP1	165904	broad.mit.edu	37	3	39226647	39226648	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:39226647_39226648GG>TT	uc003cjk.1	-	2	4510_4511	c.4289_4290CC>AA	c.(4288-4290)GCC>GAA	p.A1430E	XIRP1_uc003cji.2_3'UTR|XIRP1_uc003cjj.2_Missense_Mutation_p.A113E	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1430							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CATGGTTGAGGGCATTGAGCTT	0.644			NA											7	100					0	0	0.004672	0	0
CX3CR1	1524	broad.mit.edu	37	3	39308000	39308000	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:39308000T>C	uc003cjl.2	-	2	93	c.1A>G	c.(1-3)ATG>GTG	p.M1V		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	1	Extracellular (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		AACTGATCCATGGTGAAGGCC	0.443			NA											14	35					0	0	0.00245	0	0
ZNF662	389114	broad.mit.edu	37	3	42956151	42956151	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:42956151G>T	uc003cmi.2	+	5	938	c.586G>T	c.(586-588)GAA>TAA	p.E196*	ZNF662_uc003cmk.2_Nonsense_Mutation_p.E222*|ZNF662_uc003cmj.2_Nonsense_Mutation_p.E88*	NM_207404	NP_997287	Q6ZS27	ZN662_HUMAN	zinc finger protein 662 isoform 1	196	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(284;0.217)		TATATGTGAGGAATGCGGCAA	0.373			NA											22	46					6.33239e-15	1.02759e-14	0.010504	1	0
PFKFB4	5210	broad.mit.edu	37	3	48563006	48563006	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:48563006T>C	uc003ctv.2	-	10	1101	c.1084A>G	c.(1084-1086)AAA>GAA	p.K362E	PFKFB4_uc003ctw.2_Missense_Mutation_p.K171E|PFKFB4_uc010hkc.2_Intron|PFKFB4_uc003ctx.2_Missense_Mutation_p.K319E|PFKFB4_uc010hkb.2_Missense_Mutation_p.K355E|PFKFB4_uc011bbm.1_Missense_Mutation_p.K351E|PFKFB4_uc011bbn.1_RNA	NM_004567	NP_004558	Q16877	F264_HUMAN	6-phosphofructo-2-kinase/fructose-2,	362	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0003)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		ACCTCCCCTTTAGGGTACCGG	0.567			NA											3	24					0	0	0.004672	0	0
COL7A1	1294	broad.mit.edu	37	3	48605544	48605544	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:48605544G>C	uc003ctz.2	-	105	7855	c.7854C>G	c.(7852-7854)TTC>TTG	p.F2618L		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	2618	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGGGACCCATGAAGCCAACAT	0.532			NA											10	97					0	0	0.006214	0	0
CELSR3	1951	broad.mit.edu	37	3	48697224	48697225	+	Missense_Mutation	DNP	CT	CT	AA			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:48697224_48697225CT>AA	uc003cul.2	-	1	3124_3125	c.2843_2844AG>TT	c.(2842-2844)GAG>GTT	p.E948V	CELSR3_uc003cuf.1_Missense_Mutation_p.E1018V	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	948	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TGACCATCACCTCCACATAAGT	0.53			NA											24	76					0	0	0.004672	0	0
SLC25A20	788	broad.mit.edu	37	3	48929495	48929495	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:48929495T>G	uc003cva.3	-	2	291	c.116A>C	c.(115-117)CAG>CCG	p.Q39P	SLC25A20_uc011bbw.1_5'UTR|SLC25A20_uc010hkj.2_Missense_Mutation_p.Q39P	NM_000387	NP_000378	O43772	MCAT_HUMAN	carnitine/acylcarnitine translocase	39	Solcar 1.|Mitochondrial matrix (Potential).				carnitine shuttle|cellular lipid metabolic process|regulation of fatty acid oxidation	integral to membrane|mitochondrial inner membrane	acyl carnitine transporter activity				0				BRCA - Breast invasive adenocarcinoma(193;0.000168)|Kidney(197;0.00231)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	L-Carnitine(DB00583)	TGGCTGTGTCTGCAGTCGGAC	0.502			NA											20	56					0	0	0.001882	0	0
P4HTM	54681	broad.mit.edu	37	3	49044234	49044234	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:49044234C>A	uc003cvg.2	+	9	1752	c.1403C>A	c.(1402-1404)GCG>GAG	p.A468E	P4HTM_uc003cvh.2_Missense_Mutation_p.A529E|WDR6_uc011bbx.1_5'Flank|WDR6_uc003cvj.2_5'Flank|WDR6_uc011bby.1_5'Flank|WDR6_uc010hkn.2_5'Flank|WDR6_uc011bbz.1_5'Flank	NM_177939	NP_808808	Q9NXG6	P4HTM_HUMAN	hypoxia-inducible factor prolyl 4-hydroxylase	468	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)|pancreas(1)	2					Vitamin C(DB00126)	GCGCGGCAAGCGCTGTTCCAA	0.662			NA											5	43					2.7689e-08	3.74372e-08	0.001984	1	0
DOCK3	1795	broad.mit.edu	37	3	51370646	51370646	+	Silent	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:51370646C>G	uc011bds.1	+	35	3596	c.3573C>G	c.(3571-3573)ACC>ACG	p.T1191T		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1191	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CCTTTGTGACCTCAGTCACCC	0.527			NA											13	135					0	0	0.001855	0	0
ERC2	26059	broad.mit.edu	37	3	56468700	56468700	+	Silent	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:56468700T>A	uc003dhr.1	-	2	592	c.336A>T	c.(334-336)ACA>ACT	p.T112T		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	112						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		AAAGGACATCTGTGTGGGAAA	0.522			NA											19	170					0	0	0.006122	0	0
FLNB	2317	broad.mit.edu	37	3	58124020	58124020	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:58124020G>A	uc003djj.2	+	29	5038	c.4873G>A	c.(4873-4875)GCC>ACC	p.A1625T	FLNB_uc010hne.2_Missense_Mutation_p.A1656T|FLNB_uc003djk.2_Missense_Mutation_p.A1625T|FLNB_uc010hnf.2_Missense_Mutation_p.A1625T|FLNB_uc003djl.2_Missense_Mutation_p.A1456T|FLNB_uc003djm.2_Missense_Mutation_p.A1456T	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1625	Filamin 15.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TCCTGGAATCGCCTCCACTGT	0.522			NA											20	93					0	0	0.001882	0	0
PTPRG	5793	broad.mit.edu	37	3	61975455	61975456	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:61975455_61975456GG>AT	uc003dlb.2	+	3	1066_1067	c.347_348GG>AT	c.(346-348)TGG>TAT	p.W116Y	PTPRG_uc003dlc.2_Missense_Mutation_p.W116Y	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	116	Extracellular (Potential).|Alpha-carbonic anhydrase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		AACAAAACCTGGATGAAAAACA	0.426			NA											6	48					0	0	0.004672	0	0
CADPS	8618	broad.mit.edu	37	3	62478012	62478012	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:62478012T>A	uc003dll.2	-	20	3197	c.2837A>T	c.(2836-2838)GAC>GTC	p.D946V	CADPS_uc003dlk.1_Missense_Mutation_p.D443V|CADPS_uc003dlm.2_Missense_Mutation_p.D956V|CADPS_uc003dln.2_Missense_Mutation_p.D916V	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	946	MHD1.|Interaction with DRD2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TGGAAAACTGTCCCATGTGTC	0.448			NA											102	257					0	0	0.00361	0	0
CADPS	8618	broad.mit.edu	37	3	62478014	62478014	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:62478014C>A	uc003dll.2	-	20	3195	c.2835G>T	c.(2833-2835)TGG>TGT	p.W945C	CADPS_uc003dlk.1_Missense_Mutation_p.W442C|CADPS_uc003dlm.2_Missense_Mutation_p.W955C|CADPS_uc003dln.2_Missense_Mutation_p.W915C	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	945	MHD1.|Interaction with DRD2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GAAAACTGTCCCATGTGTCTG	0.453			NA											106	266					1.94071e-40	3.6852e-40	0.00361	1	0
PDZRN3	23024	broad.mit.edu	37	3	73433421	73433421	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:73433421T>A	uc003dpl.1	-	10	2392	c.2296A>T	c.(2296-2298)AGC>TGC	p.S766C	PDZRN3_uc011bgh.1_Missense_Mutation_p.S423C|PDZRN3_uc010hoe.1_Missense_Mutation_p.S464C|PDZRN3_uc011bgf.1_Missense_Mutation_p.S483C|PDZRN3_uc011bgg.1_Missense_Mutation_p.S486C	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	766							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		AGCGGGGTGCTGCGGCAGCTC	0.647			NA											6	40					0	0	0.001984	0	0
HTR1F	3355	broad.mit.edu	37	3	88039965	88039965	+	Silent	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:88039965C>G	uc003dqr.2	+	2	224	c.66C>G	c.(64-66)TCC>TCG	p.S22S		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	22	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	GAATGCCATCCAAAATTCTGG	0.398			NA											21	160					0	0	0.00333	0	0
EPHA3	2042	broad.mit.edu	37	3	89259220	89259220	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:89259220C>A	uc003dqy.2	+	3	589	c.364C>A	c.(364-366)CTG>ATG	p.L122M	EPHA3_uc003dqx.1_Missense_Mutation_p.L122M|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	122	Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GACATTCAACCTGTACTACAT	0.413			NA								TSP Lung(6;0.00050)			13	127					4.36969e-10	6.30677e-10	0.001855	1	0
EPHA3	2042	broad.mit.edu	37	3	89390124	89390124	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:89390124G>T	uc003dqy.2	+	4	1098	c.873G>T	c.(871-873)CCG>CCT	p.P291P	EPHA3_uc003dqx.1_Silent_p.P291P|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	291	Extracellular (Potential).|Cys-rich.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CTAAGTGCCCGCCTCACAGTT	0.438			NA								TSP Lung(6;0.00050)			10	145					6.40141e-05	7.49101e-05	0.000978	1	0
PROS1	5627	broad.mit.edu	37	3	93605239	93605240	+	Nonsense_Mutation	DNP	CC	CC	AT			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:93605239_93605240CC>AT	uc003drb.3	-	11	1604_1605	c.1263_1264GG>AT	c.(1261-1266)CTGGAA>CTATAA	p.E422*	PROS1_uc010hoo.2_Nonsense_Mutation_p.E291*|PROS1_uc003dqz.3_Nonsense_Mutation_p.E291*	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	422	Laminin G-like 1.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	ACTTTGGTTTCCAGCAATCCAT	0.376			NA											38	199					0	0	0.004672	0	0
ARL13B	200894	broad.mit.edu	37	3	93722539	93722539	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:93722539C>T	uc003drc.2	+	3	453	c.167C>T	c.(166-168)TCA>TTA	p.S56L	ARL13B_uc010hop.2_Intron|ARL13B_uc003drd.2_Intron|ARL13B_uc003dre.2_Missense_Mutation_p.S41L|ARL13B_uc003drf.2_Missense_Mutation_p.S56L|ARL13B_uc003drg.2_5'UTR	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1	56							GTP binding				0						GTTGGATTTTCAAAAATTAAC	0.338			NA											8	79					0	0	0.00308	0	0
OR5K4	403278	broad.mit.edu	37	3	98073305	98073305	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:98073305C>A	uc011bgv.1	+	1	608	c.608C>A	c.(607-609)TCA>TAA	p.S203*		NM_001005517	NP_001005517	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K,	203	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TATATCTTTTCAATACCAATT	0.328			NA											18	76					2.35188e-11	3.51982e-11	0.006122	1	0
OR5K1	26339	broad.mit.edu	37	3	98188929	98188929	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:98188929G>C	uc003dsm.2	+	1	509	c.509G>C	c.(508-510)GGA>GCA	p.G170A		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	170	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						GTTTTCTGTGGATCGAATCAC	0.398			NA											22	265					0	0	0.002299	0	0
OR5K1	26339	broad.mit.edu	37	3	98189049	98189049	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:98189049C>A	uc003dsm.2	+	1	629	c.629C>A	c.(628-630)ACC>AAC	p.T210N		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						CAAGTCTTTACCATAGGTAGT	0.348			NA											41	137					1.67305e-13	2.61308e-13	0.00623	1	0
OR5K2	402135	broad.mit.edu	37	3	98216531	98216531	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:98216531G>A	uc011bgx.1	+	1	7	c.7G>A	c.(7-9)GAA>AAA	p.E3K		NM_001004737	NP_001004737	Q8NHB8	OR5K2_HUMAN	olfactory receptor, family 5, subfamily K,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						AGGAATGGTTGAAGAAAATCA	0.373			NA											10	91					0	0	0.006214	0	0
CEP97	79598	broad.mit.edu	37	3	101443556	101443556	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:101443556C>T	uc003dvk.1	+	1	63	c.36C>T	c.(34-36)CCC>CCT	p.P12P	CEP97_uc010hpm.1_Silent_p.P12P|CEP97_uc011bhf.1_Silent_p.P12P|CEP97_uc003dvl.1_5'Flank	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	12						centrosome|nucleus	protein binding			ovary(2)	2						CTTTGCCTCCCGGAGAAGGTA	0.532			NA											9	42					0	0	0.001368	0	0
CEP97	79598	broad.mit.edu	37	3	101447769	101447769	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:101447769G>T	uc003dvk.1	+	4	462	c.435G>T	c.(433-435)TTG>TTT	p.L145F	CEP97_uc010hpm.1_Intron|CEP97_uc011bhf.1_Missense_Mutation_p.L145F|CEP97_uc003dvl.1_Intron	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	145	LRR 5.					centrosome|nucleus	protein binding			ovary(2)	2						TATCTAAATTGGTATCCCTGA	0.353			NA											9	55					0.000442599	0.000499343	0.006214	1	0
NFKBIZ	64332	broad.mit.edu	37	3	101574011	101574011	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:101574011C>G	uc003dvp.2	+	7	1664	c.1549C>G	c.(1549-1551)CTG>GTG	p.L517V	NFKBIZ_uc003dvo.2_Missense_Mutation_p.L417V|NFKBIZ_uc010hpo.2_Missense_Mutation_p.L417V|NFKBIZ_uc003dvq.2_Missense_Mutation_p.L395V	NM_031419	NP_113607	Q9BYH8	IKBZ_HUMAN	nuclear factor of kappa light polypeptide gene	517	Interaction with NFKB1/p50 (By similarity).|ANK 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(2)	2						AAGAACACCTCTGCATGTGTG	0.537			NA											4	70					0	0	0.000602	0	0
HHLA2	11148	broad.mit.edu	37	3	108095392	108095392	+	Silent	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:108095392C>G	uc003dwy.3	+	9	1379	c.1212C>G	c.(1210-1212)GGC>GGG	p.G404G	HHLA2_uc011bhl.1_Silent_p.G340G|HHLA2_uc010hpu.2_Silent_p.G387G|HHLA2_uc003dwz.2_Silent_p.G404G	NM_007072	NP_009003	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2 precursor	404						integral to membrane				ovary(1)	1						CCGATAATGGCGAAGAAAATG	0.363			NA											10	33					0	0	0.006214	0	0
MYH15	22989	broad.mit.edu	37	3	108189605	108189605	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:108189605G>T	uc003dxa.1	-	14	1440	c.1383C>A	c.(1381-1383)GCC>GCA	p.A461A		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	461	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						TTGACAGCTTGGCATCCAGGG	0.448			NA											10	43					4.68919e-08	6.2631e-08	0.008291	1	0
CD96	10225	broad.mit.edu	37	3	111342670	111342670	+	Splice_Site	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:111342670G>T	uc003dxw.2	+	10	1467	c.1297_splice	c.e10+1	p.P433_splice	CD96_uc003dxx.2_Splice_Site_p.P417_splice|CD96_uc010hpy.1_Splice_Site_p.P417_splice	NM_198196	NP_937839	P40200	TACT_HUMAN	CD96 antigen isoform 1 precursor						cell adhesion|immune response|regulation of immune response	integral to plasma membrane				skin(2)|central_nervous_system(1)	3						ACTCCTCAACGTGAGTTCAGC	0.383			NA							Opitz_Trigonocephaly_syndrome				8	46					0.000274275	0.000311722	0.004482	1	0
CCDC80	151887	broad.mit.edu	37	3	112358703	112358703	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:112358703A>G	uc003dzf.2	-	2	268	c.50T>C	c.(49-51)CTA>CCA	p.L17P	CCDC80_uc011bhv.1_Missense_Mutation_p.L17P|CCDC80_uc003dzg.2_Missense_Mutation_p.L17P|CCDC80_uc003dzh.1_Missense_Mutation_p.L17P	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	17										ovary(2)	2						TCCACACACTAGCCACATGGC	0.552			NA											8	57					0	0	0.006214	0	0
CD200R1	131450	broad.mit.edu	37	3	112648058	112648058	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:112648058C>A	uc003dzk.1	-	3	663	c.430G>T	c.(430-432)GGA>TGA	p.G144*	CD200R1_uc003dzj.1_Nonsense_Mutation_p.G167*|CD200R1_uc011bhx.1_Nonsense_Mutation_p.G122*|CD200R1_uc003dzl.1_Nonsense_Mutation_p.G167*|CD200R1_uc003dzm.1_Nonsense_Mutation_p.G144*	NM_170780	NP_740750	Q8TD46	MO2R1_HUMAN	CD200 receptor 1 isoform d	144	Ig-like C2-type.|Extracellular (Potential).				interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			ovary(2)|pancreas(1)	3						AGGTGATATCCACGATGGAAA	0.428			NA											19	93					2.4624e-09	3.4631e-09	0.008871	1	0
GTPBP8	29083	broad.mit.edu	37	3	112710111	112710111	+	Missense_Mutation	SNP	G	G	A	rs146036883	byFrequency	TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:112710111G>A	uc003dzn.2	+	1	312	c.265G>A	c.(265-267)GAA>AAA	p.E89K	GTPBP8_uc011bhy.1_RNA|GTPBP8_uc003dzp.2_RNA|GTPBP8_uc003dzo.2_Missense_Mutation_p.E89K	NM_014170	NP_054889	Q8N3Z3	GTPB8_HUMAN	GTP-binding protein 8 isoform 1	89					barrier septum formation		GTP binding				0						CACGGCCACTGAACGGAACCG	0.637			NA											4	56					0	0	0.009096	0	0
KIAA1407	57577	broad.mit.edu	37	3	113737532	113737532	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:113737532C>G	uc003eax.2	-	8	1303	c.1156G>C	c.(1156-1158)GAA>CAA	p.E386Q	KIAA1407_uc011bin.1_RNA|KIAA1407_uc011bio.1_Missense_Mutation_p.E364Q|KIAA1407_uc011bip.1_Missense_Mutation_p.E373Q	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	386	Potential.									ovary(2)	2						TACCTGTTTTCTTCCCTAAGA	0.413			NA											18	241					0	0	0.008871	0	0
LSAMP	4045	broad.mit.edu	37	3	115560789	115560789	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:115560789G>T	uc003ebt.2	-	6	1322	c.822C>A	c.(820-822)TCC>TCA	p.S274S	LSAMP_uc011bis.1_Silent_p.S274S	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	274	Ig-like C2-type 3.				cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		TCACCGTCAGGGAAGACTGGC	0.488			NA											14	89					9.31168e-06	1.1336e-05	0.001855	1	0
LSAMP	4045	broad.mit.edu	37	3	116163786	116163786	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:116163786G>T	uc003ebt.2	-	1	593	c.93C>A	c.(91-93)AGC>AGA	p.S31R	LSAMP_uc011bis.1_Missense_Mutation_p.S31R|LSAMP_uc010hqq.1_RNA	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	31	Ig-like C2-type 1.				cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		TAAAATCCACGCTGCGAACAG	0.577			NA											10	28					1.04858e-14	1.69623e-14	0.006214	1	0
C3orf15	89876	broad.mit.edu	37	3	119466073	119466073	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:119466073G>T	uc003ede.3	+	15	2091	c.2014G>T	c.(2014-2016)GAG>TAG	p.E672*	C3orf15_uc010hqz.2_Nonsense_Mutation_p.E610*|C3orf15_uc011bjd.1_Nonsense_Mutation_p.E546*|C3orf15_uc011bje.1_Nonsense_Mutation_p.E652*|C3orf15_uc003edg.3_5'Flank	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	508	Potential.					mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		GAAGATGGCTGAGAAAATCAA	0.393			NA											14	46					0.000219431	0.000251245	0.00245	1	0
GPR156	165829	broad.mit.edu	37	3	119887165	119887165	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:119887165T>A	uc011bjf.1	-	9	1159	c.1159A>T	c.(1159-1161)ATG>TTG	p.M387L	GPR156_uc011bjg.1_Missense_Mutation_p.M383L	NM_153002	NP_694547	Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	387	Cytoplasmic (Potential).|Potential.					integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.19)		TCAGCTGACATCAGCCTCACA	0.512			NA											25	49					0	0	0.003954	0	0
STXBP5L	9515	broad.mit.edu	37	3	121126217	121126217	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:121126217G>T	uc003eec.3	+	24	2927	c.2787G>T	c.(2785-2787)TGG>TGT	p.W929C	STXBP5L_uc011bji.1_Missense_Mutation_p.W905C	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	929	WD 12.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		AAAAATCTTGGAGAAGGAAAG	0.393			NA											20	53					7.41877e-09	1.0265e-08	0.001882	1	0
GOLGB1	2804	broad.mit.edu	37	3	121417022	121417022	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:121417022C>G	uc003eei.3	-	13	2459	c.2333G>C	c.(2332-2334)AGG>ACG	p.R778T	GOLGB1_uc010hrc.2_Missense_Mutation_p.R783T|GOLGB1_uc003eej.3_Missense_Mutation_p.R744T|GOLGB1_uc011bjm.1_Missense_Mutation_p.R664T|GOLGB1_uc010hrd.1_Missense_Mutation_p.R742T	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	778	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TCTTCTTTGCCTTTCTGCTTC	0.433			NA											42	123					0	0	0.002852	0	0
EEFSEC	60678	broad.mit.edu	37	3	127983561	127983561	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:127983561G>T	uc003eki.2	+	4	761	c.723G>T	c.(721-723)ATG>ATT	p.M241I	EEFSEC_uc003ekj.2_Intron	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	241						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						GCACTGTGATGACAGGGACCA	0.562			NA											38	111					2.52637e-11	3.7773e-11	0.005524	1	0
KIAA1257	57501	broad.mit.edu	37	3	128695883	128695883	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:128695883A>T	uc003elj.3	-	6	1031	c.835T>A	c.(835-837)TCT>ACT	p.S279T	KIAA1257_uc003elg.1_Missense_Mutation_p.S279T|KIAA1257_uc003eli.3_Missense_Mutation_p.S167T	NM_020741	NP_065792	Q9ULG3	K1257_HUMAN	hypothetical protein LOC57501	279											0						TTCTTGGAAGAAGTTTCGGGC	0.443			NA											5	73					0	0	0.001168	0	0
ATP2C1	27032	broad.mit.edu	37	3	130678149	130678149	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:130678149G>T	uc003enl.2	+	12	1085	c.863G>T	c.(862-864)GGA>GTA	p.G288V	ATP2C1_uc011blg.1_Missense_Mutation_p.G322V|ATP2C1_uc011blh.1_Missense_Mutation_p.G283V|ATP2C1_uc011bli.1_Missense_Mutation_p.G322V|ATP2C1_uc003enk.2_Missense_Mutation_p.G272V|ATP2C1_uc003enm.2_Missense_Mutation_p.G288V|ATP2C1_uc003enn.2_Missense_Mutation_p.G272V|ATP2C1_uc003eno.2_Missense_Mutation_p.G288V|ATP2C1_uc003enp.2_Missense_Mutation_p.G288V|ATP2C1_uc003enq.2_Missense_Mutation_p.G288V|ATP2C1_uc003enr.2_Missense_Mutation_p.G288V|ATP2C1_uc003ens.2_Missense_Mutation_p.G288V|ATP2C1_uc003ent.2_Missense_Mutation_p.G288V	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	288	Lumenal (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	TGGTTACTGGGAAAAGATATC	0.333	Esophageal Squamous(99;456 1443 27647 34099 42636)		NA							Hailey-Hailey_disease				9	34					0.000978159	0.00108999	0.000978	1	0
TF	7018	broad.mit.edu	37	3	133478117	133478117	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:133478117G>C	uc003epu.1	+	14	2875	c.1147G>C	c.(1147-1149)GGG>CGG	p.G383R	TF_uc011blt.1_Missense_Mutation_p.G256R|TF_uc003epw.1_Intron|TF_uc003epv.1_Missense_Mutation_p.G383R	NM_001063	NP_001054	P02787	TRFE_HUMAN	transferrin precursor	383	Transferrin-like 2.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	TAACAGTGTAGGGAAAATAGA	0.532			NA											26	113					0	0	0.003954	0	0
EPHB1	2047	broad.mit.edu	37	3	134670882	134670882	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:134670882G>T	uc003eqt.2	+	3	1013	c.793G>T	c.(793-795)GTG>TTG	p.V265L	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_Intron	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	265	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						TGAGAACAGCGTGGCATGCAA	0.552			NA											32	135					2.68265e-12	4.09186e-12	0.002836	1	0
A4GNT	51146	broad.mit.edu	37	3	137850009	137850009	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:137850009G>T	uc003ers.2	-	2	292	c.90C>A	c.(88-90)CTC>CTA	p.L30L		NM_016161	NP_057245	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	30	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)	1						GCAAACAGAAGAGGCAGCTGG	0.557			NA											27	61					2.65835e-16	4.40673e-16	0.007291	1	0
TRIM42	287015	broad.mit.edu	37	3	140397213	140397213	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:140397213C>A	uc003eto.1	+	1	333	c.142C>A	c.(142-144)CGG>AGG	p.R48R		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	48	Cys-rich.					intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						CAAAGATGAGCGGAACTGCCA	0.542			NA											17	169					2.23348e-06	2.78733e-06	0.004007	1	0
SLC9A9	285195	broad.mit.edu	37	3	143214218	143214218	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:143214218G>T	uc003evn.2	-	10	1344	c.1162C>A	c.(1162-1164)CAG>AAG	p.Q388K		NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	388	Helical; (Potential).				regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						ATATGATTCTGGAACGTGAAC	0.353			NA											44	129					1.0096e-33	1.89839e-33	0.00361	1	0
PLOD2	5352	broad.mit.edu	37	3	145809634	145809634	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:145809634C>A	uc003evs.1	-	8	1338	c.832G>T	c.(832-834)GGC>TGC	p.G278C	PLOD2_uc011bnm.1_Missense_Mutation_p.G223C|PLOD2_uc003evr.1_Missense_Mutation_p.G278C	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	278					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	AGAGTGCAGCCATTATCCTGT	0.363			NA											9	40					0.000978159	0.00108999	0.000978	1	0
PLSCR4	57088	broad.mit.edu	37	3	145912942	145912942	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:145912942T>A	uc010huy.2	-	8	1243	c.914A>T	c.(913-915)AAA>ATA	p.K305I	PLSCR4_uc010huz.2_Missense_Mutation_p.K305I|PLSCR4_uc003evt.3_Missense_Mutation_p.K305I|PLSCR4_uc010hva.2_Missense_Mutation_p.K215I|PLSCR4_uc003evu.3_Missense_Mutation_p.K200I	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	305	Helical; (Potential).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						AATCATGGCTTTCATCTTCAC	0.373			NA											14	43					0	0	0.001855	0	0
ZIC4	84107	broad.mit.edu	37	3	147114196	147114196	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:147114196G>A	uc003ewd.1	-	3	404	c.131C>T	c.(130-132)CCG>CTG	p.P44L	ZIC4_uc003ewc.1_5'UTR|ZIC4_uc011bno.1_Missense_Mutation_p.P94L	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	44						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GTGGAGGCCCGGGAACACCGA	0.677			NA											6	29					0	0	0.001168	0	0
AGTR1	185	broad.mit.edu	37	3	148459392	148459392	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:148459392C>T	uc003ewg.2	+	4	1016	c.570C>T	c.(568-570)ACC>ACT	p.T190T	AGTR1_uc003ewh.2_Silent_p.T190T|AGTR1_uc003ewi.2_Silent_p.T190T|AGTR1_uc003ewj.2_Silent_p.T190T|AGTR1_uc003ewk.2_Silent_p.T190T	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	190	Extracellular (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	AAAATTCAACCCTCCCGATAG	0.398			NA											9	76					0	0	0.008291	0	0
HPS3	84343	broad.mit.edu	37	3	148847543	148847543	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:148847543G>T	uc003ewu.1	+	1	173	c.33G>T	c.(31-33)GGG>GGT	p.G11G	HPS3_uc003ewt.1_Silent_p.G11G|HPS3_uc011bnq.1_Silent_p.G11G	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	11						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			ACCCGTTCGGGTCGCAGCAGG	0.726			NA							Hermansky-Pudlak_syndrome				6	14					8.12818e-05	9.43997e-05	0.001984	1	0
MED12L	116931	broad.mit.edu	37	3	151083776	151083776	+	Silent	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:151083776A>G	uc003eyp.2	+	21	3257	c.3219A>G	c.(3217-3219)GTA>GTG	p.V1073V	MED12L_uc011bnz.1_Silent_p.V933V|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Silent_p.V236V	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1073					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTTGCACTGTAGATGTAAGTT	0.343			NA											16	133					0	0	0.00499	0	0
P2RY1	5028	broad.mit.edu	37	3	152553901	152553901	+	Nonsense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:152553901C>G	uc003ezq.2	+	1	1166	c.330C>G	c.(328-330)TAC>TAG	p.Y110*		NM_002563	NP_002554	P47900	P2RY1_HUMAN	purinergic receptor P2Y1	110	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			TGATCTTCTACTACTTCAATA	0.478			NA											20	82					0	0	0.010504	0	0
GPR149	344758	broad.mit.edu	37	3	154147120	154147120	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:154147120G>A	uc003faa.2	-	1	385	c.285C>T	c.(283-285)AAC>AAT	p.N95N		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	95	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			CGGGGACCTCGTTTGGCCACT	0.498			NA											29	102					0	0	0.009535	0	0
KCNAB1	7881	broad.mit.edu	37	3	156170725	156170725	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:156170725G>T	uc003far.2	+	3	421	c.357G>T	c.(355-357)GAG>GAT	p.E119D	KCNAB1_uc011bon.1_Missense_Mutation_p.E119D|KCNAB1_uc003fas.2_Missense_Mutation_p.E108D|KCNAB1_uc003fat.2_Missense_Mutation_p.E101D|KCNAB1_uc010hvt.1_Missense_Mutation_p.E101D	NM_172160	NP_751892	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related	119						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TTTCAGATGAGGTAAGTTACC	0.368			NA											43	168					2.01807e-28	3.69979e-28	0.00361	1	0
IQCJ	654502	broad.mit.edu	37	3	158983078	158983078	+	Silent	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:158983078T>A	uc003fcp.1	+	5	471	c.366T>A	c.(364-366)CCT>CCA	p.P122P	SCHIP1_uc003fcq.1_Intron|SCHIP1_uc003fcr.1_Intron|IQCJ_uc010hvy.1_Silent_p.P95P	NM_001042705	NP_001036170	Q1A5X6	IQCJ_HUMAN	IQ motif containing J isoform CaMBPv1	122											0			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			ACAAGTTGCCTGGTGGAAGGA	0.493			NA											38	173					0	0	0.006999	0	0
SI	6476	broad.mit.edu	37	3	164709192	164709192	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:164709192C>T	uc003fei.2	-	44	5119	c.5057G>A	c.(5056-5058)CGT>CAT	p.R1686H		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1686	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTGACCACCACGGACATGTAG	0.388			NA								HNSCC(35;0.089)			10	64					0	0	0.000978	0	0
SI	6476	broad.mit.edu	37	3	164710132	164710132	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:164710132G>T	uc003fei.2	-	42	4957	c.4895C>A	c.(4894-4896)CCA>CAA	p.P1632Q		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1632	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CATAAATGCTGGACCCCATAA	0.313			NA								HNSCC(35;0.089)			5	62					3.59834e-05	4.24306e-05	0.001168	1	0
SLITRK3	22865	broad.mit.edu	37	3	164906357	164906357	+	Silent	SNP	G	G	T	rs146211129		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:164906357G>T	uc003fej.3	-	2	2706	c.2262C>A	c.(2260-2262)CCC>CCA	p.P754P	SLITRK3_uc003fek.2_Silent_p.P754P	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	754	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						GCTTGTAGATGGGGTTGTTGC	0.557			NA								HNSCC(40;0.11)			23	107					1.96895e-08	2.67152e-08	0.00278	1	0
SLC7A14	57709	broad.mit.edu	37	3	170244607	170244607	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:170244607C>G	uc003fgz.2	-	2	435	c.119G>C	c.(118-120)GGG>GCG	p.G40A	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	40						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			CGTGGTGGTCCCAGTTCCCTC	0.597			NA											17	36					0	0	0.00499	0	0
ECT2	1894	broad.mit.edu	37	3	172474945	172474945	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:172474945A>G	uc003fii.2	+	4	521	c.383A>G	c.(382-384)CAA>CGA	p.Q128R	ECT2_uc010hwv.1_Missense_Mutation_p.Q159R|ECT2_uc003fih.2_Missense_Mutation_p.Q127R|ECT2_uc003fij.1_Missense_Mutation_p.Q128R|ECT2_uc003fik.1_Missense_Mutation_p.Q128R|ECT2_uc003fil.1_Missense_Mutation_p.Q159R	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	128					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			AATTGTTCACAAAAAGGAGAG	0.264			NA											5	78					0	0	0.000602	0	0
NLGN1	22871	broad.mit.edu	37	3	173322611	173322611	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:173322611G>T	uc003fio.1	+	3	646	c.223G>T	c.(223-225)GGG>TGG	p.G75W	NLGN1_uc010hww.1_Missense_Mutation_p.G75W|NLGN1_uc003fip.1_Missense_Mutation_p.G75W	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	75	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			TGAAATTTTGGGGCCTGTTAT	0.458			NA											36	136					1.06647e-15	1.7472e-15	0.003755	1	0
ABCF3	55324	broad.mit.edu	37	3	183907380	183907380	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:183907380C>A	uc003fmz.2	+	13	1282	c.1149C>A	c.(1147-1149)GAC>GAA	p.D383E	ABCF3_uc003fna.2_Missense_Mutation_p.D377E|ABCF3_uc003fnb.2_Missense_Mutation_p.D64E	NM_018358	NP_060828	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20),	383	ABC transporter 1.						ATP binding|ATPase activity			ovary(3)|lung(1)	4	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TCTCCCACGACCGCAACTTCT	0.587			NA											6	51					5.9392e-07	7.59035e-07	0.001168	1	0
EIF4G1	1981	broad.mit.edu	37	3	184045208	184045208	+	Silent	SNP	G	G	T	rs113108196		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:184045208G>T	uc003fnp.2	+	24	3831	c.3633G>T	c.(3631-3633)ACG>ACT	p.T1211T	EIF4G1_uc003fnt.2_Silent_p.T922T|EIF4G1_uc003fnq.2_Silent_p.T1124T|EIF4G1_uc003fnr.2_Silent_p.T1047T|EIF4G1_uc010hxx.2_Silent_p.T1218T|EIF4G1_uc003fns.2_Silent_p.T1171T|EIF4G1_uc010hxy.2_Silent_p.T1218T|EIF4G1_uc003fnv.3_Silent_p.T1212T|EIF4G1_uc003fnu.3_Silent_p.T1211T|EIF4G1_uc003fnw.2_Silent_p.T1218T|EIF4G1_uc003fnx.2_Silent_p.T1016T|EIF4G1_uc003fny.3_Silent_p.T1015T|EIF4G1_uc003foa.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1211					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CTAGCCTCACGGAGGATCGGG	0.627			NA											20	60					1.33834e-09	1.89434e-09	0.007413	1	0
EIF4G1	1981	broad.mit.edu	37	3	184046479	184046479	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:184046479C>T	uc003fnp.2	+	27	4212	c.4014C>T	c.(4012-4014)CTC>CTT	p.L1338L	EIF4G1_uc003fnt.2_Silent_p.L1049L|EIF4G1_uc003fnq.2_Silent_p.L1251L|EIF4G1_uc003fnr.2_Silent_p.L1174L|EIF4G1_uc010hxx.2_Silent_p.L1345L|EIF4G1_uc003fns.2_Silent_p.L1298L|EIF4G1_uc010hxy.2_Silent_p.L1345L|EIF4G1_uc003fnv.3_Silent_p.L1339L|EIF4G1_uc003fnu.3_Silent_p.L1338L|EIF4G1_uc003fnw.2_Silent_p.L1345L|EIF4G1_uc003fnx.2_Silent_p.L1143L|EIF4G1_uc003fny.3_Silent_p.L1142L|EIF4G1_uc003foa.2_Silent_p.L10L	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1338	MI.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ACGTGTGGCTCTACCTAGCGG	0.522			NA											46	141					0	0	0.009718	0	0
EIF4G1	1981	broad.mit.edu	37	3	184052538	184052538	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:184052538G>T	uc003fnp.2	+	33	4840	c.4642G>T	c.(4642-4644)GCA>TCA	p.A1548S	EIF4G1_uc003fnt.2_Missense_Mutation_p.A1259S|EIF4G1_uc003fnq.2_Missense_Mutation_p.A1461S|EIF4G1_uc003fnr.2_Missense_Mutation_p.A1384S|EIF4G1_uc010hxx.2_Missense_Mutation_p.A1555S|EIF4G1_uc003fns.2_Missense_Mutation_p.A1508S|EIF4G1_uc010hxy.2_Missense_Mutation_p.A1555S|EIF4G1_uc003fnv.3_Missense_Mutation_p.A1549S|EIF4G1_uc003fnu.3_Missense_Mutation_p.A1548S|EIF4G1_uc003fnw.2_Missense_Mutation_p.A1555S|EIF4G1_uc003fny.3_Missense_Mutation_p.A1352S|EIF4G1_uc003foa.2_Missense_Mutation_p.A220S|FAM131A_uc003fob.1_5'Flank|FAM131A_uc003foc.2_5'Flank|FAM131A_uc003fod.1_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1548	W2.|EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GTTCTTTGACGCACTGTATGA	0.602			NA											5	77					0.000602214	0.000674971	0.000602	1	0
CHRD	8646	broad.mit.edu	37	3	184102866	184102866	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:184102866G>T	uc003fov.2	+	14	1904	c.1658G>T	c.(1657-1659)GGG>GTG	p.G553V	CHRD_uc003fow.2_Missense_Mutation_p.G183V|CHRD_uc003fox.2_Missense_Mutation_p.G553V|CHRD_uc003foy.2_Missense_Mutation_p.G183V|CHRD_uc010hyc.2_Missense_Mutation_p.G143V|CHRD_uc011brr.1_Missense_Mutation_p.G183V	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	553	CHRD 4.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CAAGCAGCAGGGCACGCCTGG	0.617			NA											55	149					2.29192e-23	4.06162e-23	0.00361	1	0
DGKG	1608	broad.mit.edu	37	3	186002472	186002472	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:186002472C>T	uc003fqa.2	-	7	1108	c.571G>A	c.(571-573)GAG>AAG	p.E191K	DGKG_uc003fqb.2_Missense_Mutation_p.E191K|DGKG_uc003fqc.2_Missense_Mutation_p.E191K|DGKG_uc011brx.1_Missense_Mutation_p.E191K	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	191	EF-hand 1.|1 (Potential).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	AGACCGTTCTCATCTGAATCA	0.502			NA											30	98					0	0	0.002445	0	0
RFC4	5984	broad.mit.edu	37	3	186515344	186515344	+	Silent	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:186515344T>A	uc003fqz.2	-	4	493	c.270A>T	c.(268-270)GCA>GCT	p.A90A	RFC4_uc011bsc.1_Silent_p.A90A|RFC4_uc011bsd.1_Silent_p.A90A	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	90					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		CTCTAGCTGCTGCCAAAATAG	0.323			NA											18	105					0	0	0.010504	0	0
CCDC50	152137	broad.mit.edu	37	3	191075856	191075856	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:191075856A>G	uc003fsw.2	+	3	772	c.182A>G	c.(181-183)CAG>CGG	p.Q61R	CCDC50_uc003fsv.2_Missense_Mutation_p.Q61R	NM_174908	NP_777568	Q8IVM0	CCD50_HUMAN	Ymer protein short isoform	61						cytoplasm	protein binding				0	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		GTGGCTAAGCAGCTCCAAGAG	0.512			NA											22	158					0	0	0.001882	0	0
ATP13A5	344905	broad.mit.edu	37	3	193029655	193029655	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:193029655C>A	uc011bsq.1	-	20	2395	c.2395G>T	c.(2395-2397)GGG>TGG	p.G799W		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	799					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		TATGATTTCCCACTCATTGCA	0.403			NA											18	65					3.52763e-06	4.3565e-06	0.00499	1	0
LRRC15	131578	broad.mit.edu	37	3	194081494	194081494	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:194081494C>A	uc003ftu.2	-	2	365	c.279G>T	c.(277-279)ACG>ACT	p.T93T	LRRC15_uc003ftt.2_Silent_p.T99T	NM_130830	NP_570843	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15 isoform b	93	LRR 2.|Extracellular (Potential).					integral to membrane				ovary(3)	3	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		AGGCCCCAGGCGTGATGCGCG	0.587			NA											13	43					1.05317e-09	1.50035e-09	0.00245	1	0
ZFYVE28	57732	broad.mit.edu	37	4	2306871	2306871	+	Missense_Mutation	SNP	C	C	T	rs73203327	by1000genomes	TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:2306871C>T	uc003gex.1	-	8	1515	c.1196G>A	c.(1195-1197)CGC>CAC	p.R399H	ZFYVE28_uc011bvk.1_Missense_Mutation_p.R329H|ZFYVE28_uc011bvl.1_Missense_Mutation_p.R369H|ZFYVE28_uc003gew.1_Missense_Mutation_p.R285H	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	399					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						GAAGAACACGCGCTCCTCCTC	0.697			NA											17	36					0	0	0.004007	0	0
HTT	3064	broad.mit.edu	37	4	3201610	3201610	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:3201610G>A	uc011bvq.1	+	42	5671	c.5526G>A	c.(5524-5526)CTG>CTA	p.L1842L		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	1840					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GTCAGATACTGCTGCTTGTCA	0.617			NA											12	30					0	0	0.001368	0	0
SLC2A9	56606	broad.mit.edu	37	4	10027569	10027569	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:10027569G>T	uc003gmd.2	-	2	181	c.22C>A	c.(22-24)CGA>AGA	p.R8R		NM_001001290	NP_001001290	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	Error:Variant_position_missing_in_Q9NRM0_after_alignment					glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						TCTTCTCCTCGGTCCTTTTTA	0.393			NA											18	42					1.01871e-10	1.49983e-10	0.008871	1	0
RAB28	9364	broad.mit.edu	37	4	13370268	13370268	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:13370268C>A	uc003gmu.2	-	7	795	c.580G>T	c.(580-582)GTG>TTG	p.V194L	RAB28_uc003gmt.2_3'UTR|RAB28_uc011bwz.1_3'UTR|RAB28_uc003gmv.2_RNA	NM_001017979	NP_001017979	P51157	RAB28_HUMAN	RAB28, member RAS oncogene family isoform 1	194					small GTPase mediated signal transduction	plasma membrane	GDP binding|GTP binding|GTPase activity			ovary(1)|skin(1)	2						TCTGCCTTCACCACCCTCTGT	0.368			NA											7	26					2.0095e-06	2.51391e-06	0.001984	1	0
BOD1L	259282	broad.mit.edu	37	4	13610219	13610219	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:13610219G>A	uc003gmz.1	-	8	1794	c.1677C>T	c.(1675-1677)GTC>GTT	p.V559V	BOD1L_uc010idr.1_5'UTR	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	559	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						GTTCTTTAAGGACTTCTTTAA	0.338			NA											3	12					0	0	0.004672	0	0
NCAPG	64151	broad.mit.edu	37	4	17819644	17819644	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:17819644G>T	uc003gpp.2	+	7	1227	c.1051G>T	c.(1051-1053)GAT>TAT	p.D351Y	NCAPG_uc011bxj.1_5'UTR	NM_022346	NP_071741	Q9BPX3	CND3_HUMAN	chromosome condensation protein G	351					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			large_intestine(1)	1				STAD - Stomach adenocarcinoma(129;0.18)		ATCAAAAGGAGATGAAGGTGA	0.323			NA											40	92					2.19962e-31	4.10099e-31	0.00874	1	0
SLIT2	9353	broad.mit.edu	37	4	20543209	20543209	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:20543209G>A	uc003gpr.1	+	20	2314	c.2110G>A	c.(2110-2112)GAT>AAT	p.D704N	SLIT2_uc003gps.1_Missense_Mutation_p.D696N	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	704	LRRCT 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						ACCCATCCAGGATGTGGCCAT	0.443			NA											7	48					0	0	0.001984	0	0
CCDC149	91050	broad.mit.edu	37	4	24838915	24838915	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:24838915C>A	uc011bxr.1	-	7	741	c.597G>T	c.(595-597)CTG>CTT	p.L199L	CCDC149_uc003grc.2_Silent_p.L199L|CCDC149_uc003grb.2_RNA|CCDC149_uc003grd.2_Intron|CCDC149_uc003gre.2_Silent_p.L144L|CCDC149_uc011bxq.1_Silent_p.L72L	NM_173463	NP_775734	B4DZG3	B4DZG3_HUMAN	coiled-coil domain containing 149 isoform 1	199											0		Breast(46;0.173)				GGATATGGTTCAGCTCCTGGT	0.572			NA											10	32					7.48243e-07	9.50738e-07	0.006214	1	0
SEL1L3	23231	broad.mit.edu	37	4	25780789	25780789	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:25780789C>A	uc003gru.3	-	16	2646	c.2494G>T	c.(2494-2496)GGT>TGT	p.G832C	SEL1L3_uc003grv.2_Missense_Mutation_p.G239C	NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	832	Sel1-like 6.					integral to membrane	binding				0						ATGTGTCCACCTTGCGCAGCC	0.473			NA											14	95					1.3612e-06	1.72248e-06	0.003163	1	0
CCKAR	886	broad.mit.edu	37	4	26483736	26483736	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:26483736G>T	uc003gse.1	-	5	964	c.811C>A	c.(811-813)CTG>ATG	p.L271M		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	271	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	GTCTTTTGCAGGTAACACCCA	0.602			NA											41	62					3.09479e-21	5.3792e-21	0.006999	1	0
TLR10	81793	broad.mit.edu	37	4	38774993	38774993	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:38774993G>T	uc003gti.2	-	2	2598	c.2219C>A	c.(2218-2220)ACC>AAC	p.T740N	TLR10_uc003gtj.2_Missense_Mutation_p.T740N|TLR10_uc003gtk.2_Missense_Mutation_p.T740N	NM_030956	NP_112218	Q9BXR5	TLR10_HUMAN	toll-like receptor 10 precursor	740	TIR.|Cytoplasmic (Potential).				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			lung(1)|breast(1)	2						ATGATACCTGGTGGGAATGCA	0.403			NA											57	80					3.07002e-29	5.65529e-29	0.00361	1	0
GABRB1	2560	broad.mit.edu	37	4	47405711	47405711	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:47405711C>A	uc003gxh.2	+	7	1192	c.818C>A	c.(817-819)GCA>GAA	p.A273E	GABRB1_uc011bze.1_Missense_Mutation_p.A203E	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	273	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GATGCATCTGCAGCCAGAGTC	0.393			NA											7	59					2.0095e-06	2.51391e-06	0.001984	1	0
CORIN	10699	broad.mit.edu	37	4	47663854	47663854	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:47663854T>C	uc003gxm.2	-	12	1702	c.1609A>G	c.(1609-1611)AAA>GAA	p.K537E	CORIN_uc011bzf.1_Missense_Mutation_p.K398E|CORIN_uc011bzg.1_Missense_Mutation_p.K470E|CORIN_uc011bzh.1_Missense_Mutation_p.K500E|CORIN_uc011bzi.1_Missense_Mutation_p.K500E	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	537	Extracellular (Potential).|FZ 2.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2						CAGCGTTCTTTAGAGTGTTCA	0.403			NA											5	36					0	0	0.001168	0	0
USP46	64854	broad.mit.edu	37	4	53494232	53494232	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:53494232C>A	uc003gzn.2	-	3	401	c.216G>T	c.(214-216)AAG>AAT	p.K72N	USP46_uc003gzm.3_Missense_Mutation_p.K65N|USP46_uc011bzr.1_Missense_Mutation_p.K49N|USP46_uc011bzs.1_5'UTR	NM_022832	NP_073743	P62068	UBP46_HUMAN	ubiquitin specific peptidase 46 isoform 1	72					behavior|protein deubiquitination|regulation of synaptic transmission, GABAergic|ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)	1			LUSC - Lung squamous cell carcinoma(32;0.0295)			AGTTTTCCTTCTTCTTTTGCT	0.493			NA											16	51					6.31663e-08	8.3931e-08	0.003163	1	0
EXOC1	55763	broad.mit.edu	37	4	56726659	56726659	+	Silent	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:56726659A>G	uc003hbe.1	+	3	365	c.207A>G	c.(205-207)GCA>GCG	p.A69A	EXOC1_uc003hbf.1_Silent_p.A69A|EXOC1_uc003hbg.1_Silent_p.A69A	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	exocyst complex component 1 isoform 1	69					exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)					GGCAGATTGCATGGGCCCTTC	0.428			NA											18	77					0	0	0.010504	0	0
KIAA1211	57482	broad.mit.edu	37	4	57193889	57193889	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:57193889C>T	uc003hbk.2	+	11	4012	c.3621C>T	c.(3619-3621)CCC>CCT	p.P1207P	KIAA1211_uc010iha.2_Silent_p.P1200P	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	1207										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					ATGCTGCCCCCGTGTCAACAG	0.527			NA											29	131					0	0	0.003755	0	0
LPHN3	23284	broad.mit.edu	37	4	62679563	62679563	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:62679563C>T	uc010ihh.2	+	6	1405	c.1232C>T	c.(1231-1233)CCG>CTG	p.P411L	LPHN3_uc003hcq.3_Missense_Mutation_p.P411L|LPHN3_uc003hcs.1_Missense_Mutation_p.P240L	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	411	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						tacatttctccgccaattcac	0.134			NA											5	42					0	0	0.001168	0	0
UGT2B28	54490	broad.mit.edu	37	4	70156342	70156342	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:70156342G>T	uc003hej.2	+	5	1125	c.1123G>T	c.(1123-1125)GGT>TGT	p.G375C	UGT2B28_uc010ihr.2_Intron	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	375					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	TATAACTCATGGTGGAGCCAA	0.398			NA											42	147					1.23713e-20	2.13825e-20	0.00361	1	0
UGT2B4	7363	broad.mit.edu	37	4	70346427	70346427	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:70346427C>A	uc003hek.3	-	6	1559	c.1512G>T	c.(1510-1512)GTG>GTT	p.V504V	UGT2B4_uc011cap.1_Silent_p.V368V|UGT2B4_uc003hel.3_3'UTR	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	504	Helical; (Potential).				estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						TGATGAATATCACAGTTGCCA	0.488			NA											36	117					1.07637e-12	1.6543e-12	0.004878	1	0
UGT2B4	7363	broad.mit.edu	37	4	70346556	70346556	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:70346556G>T	uc003hek.3	-	6	1430	c.1383C>A	c.(1381-1383)GTC>GTA	p.V461V	UGT2B4_uc011cap.1_Silent_p.V325V|UGT2B4_uc003hel.3_3'UTR	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	461					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						CAATCCAGAAGACTGCTCGAT	0.438			NA											34	137					3.03874e-20	5.23452e-20	0.003271	1	0
UGT2A1	10941	broad.mit.edu	37	4	70465104	70465104	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:70465104T>C	uc003hem.3	-	2	787	c.724A>G	c.(724-726)ACT>GCT	p.T242A	UGT2A1_uc011caq.1_Missense_Mutation_p.T452A|UGT2A1_uc010ihu.2_Missense_Mutation_p.T286A|UGT2A1_uc010iht.2_Missense_Mutation_p.T242A|UGT2A1_uc010ihs.2_Missense_Mutation_p.T243A	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	242	Extracellular (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						CATAACGTAGTGGGTCTTCCT	0.368			NA											13	60					0	0	0.001368	0	0
ODAM	54959	broad.mit.edu	37	4	71066320	71066320	+	Splice_Site	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:71066320T>C	uc003hfc.2	+	6	545	c.528_splice	c.e6+2	p.Q176_splice		NM_017855	NP_060325	A1E959	ODAM_HUMAN	odontogenic ameloblast-associated protein						biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				ovary(3)|large_intestine(1)	4						GAGGAGCAGGTACTGCAAATG	0.358			NA											13	30					0	0	0.001368	0	0
NPFFR2	10886	broad.mit.edu	37	4	72897709	72897709	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:72897709C>A	uc003hgg.2	+	1	189	c.91C>A	c.(91-93)CGC>AGC	p.R31S	NPFFR2_uc010iig.1_5'UTR	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	31	Extracellular (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			GGGGAGGGAGCGCAGAGCACT	0.657			NA											14	34					1.15088e-07	1.5071e-07	0.004007	1	0
NPFFR2	10886	broad.mit.edu	37	4	72994430	72994430	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:72994430A>T	uc003hgg.2	+	2	526	c.428A>T	c.(427-429)CAG>CTG	p.Q143L	NPFFR2_uc010iig.1_Intron|NPFFR2_uc003hgi.2_Missense_Mutation_p.Q44L|NPFFR2_uc003hgh.2_Missense_Mutation_p.Q41L	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	143	Extracellular (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TATCTTCACCAGCCTCAAGTG	0.368			NA											15	80					0	0	0.00245	0	0
ANKRD17	26057	broad.mit.edu	37	4	73956695	73956695	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:73956695G>A	uc003hgp.2	-	29	6767	c.6650C>T	c.(6649-6651)TCT>TTT	p.S2217F	ANKRD17_uc003hgo.2_Missense_Mutation_p.S2104F|ANKRD17_uc003hgq.2_Missense_Mutation_p.S1966F|ANKRD17_uc003hgr.2_Missense_Mutation_p.S2216F	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	2217					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TAGCTGGACAGAAGAGGGAAC	0.453			NA											22	251					0	0	0.00333	0	0
PARM1	25849	broad.mit.edu	37	4	75937772	75937772	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:75937772C>T	uc003hih.1	+	2	421	c.181C>T	c.(181-183)CAC>TAC	p.H61Y		NM_015393	NP_056208	Q6UWI2	PARM1_HUMAN	prostatic androgen-repressed message-1	61	Extracellular (Potential).				positive regulation of telomerase activity	early endosome|endosome membrane|Golgi membrane|integral to membrane|late endosome|plasma membrane				ovary(1)	1						CAACGGCACTCACAACAACTC	0.517			NA											7	68					0	0	0.001984	0	0
CXCL9	4283	broad.mit.edu	37	4	76927368	76927368	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:76927368G>T	uc003hjh.1	-	2	163	c.124C>A	c.(124-126)CAC>AAC	p.H42N		NM_002416	NP_002407	Q07325	CXCL9_HUMAN	small inducible cytokine B9 precursor	42					cell-cell signaling|cellular defense response|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response	extracellular space	chemokine activity			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GATTGTAGGTGGATAGTCCCT	0.453			NA											33	178					2.61193e-14	4.15106e-14	0.009535	1	0
FRAS1	80144	broad.mit.edu	37	4	79204011	79204011	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:79204011G>T	uc003hlb.2	+	12	1585	c.1145G>T	c.(1144-1146)TGT>TTT	p.C382F	FRAS1_uc003hkw.2_Missense_Mutation_p.C382F|FRAS1_uc003hky.1_Missense_Mutation_p.C86F|FRAS1_uc003hkz.2_Missense_Mutation_p.C86F	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	382	VWFC 6.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TGCAAGGTGTGTGAGTGCCGA	0.537			NA											13	95					4.93089e-13	7.65481e-13	0.00245	1	0
NAA11	84779	broad.mit.edu	37	4	80246593	80246593	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:80246593T>A	uc003hlt.3	-	1	579	c.439A>T	c.(439-441)ATG>TTG	p.M147L		NM_032693	NP_116082	Q9BSU3	NAA11_HUMAN	alpha-N-acetyltransferase 1B	147	N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2						TCCCGCTTCATAGCATAAGCA	0.512			NA											13	74					0	0	0.001855	0	0
FGF5	2250	broad.mit.edu	37	4	81188290	81188290	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:81188290C>A	uc003hmd.2	+	1	549	c.312C>A	c.(310-312)TAC>TAA	p.Y104*	FGF5_uc003hme.2_Nonsense_Mutation_p.Y104*	NM_004464	NP_004455	P12034	FGF5_HUMAN	fibroblast growth factor 5 isoform 1 precursor	104					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			ovary(1)|breast(1)	2						TGCAGATCTACCCGGATGGCA	0.577			NA											16	86					1.5739e-10	2.30838e-10	0.004007	1	0
HNRPDL	9987	broad.mit.edu	37	4	83347646	83347646	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:83347646C>A	uc003hmr.2	-	6	1697	c.1162G>T	c.(1162-1164)GGA>TGA	p.G388*	HNRPDL_uc003hmq.2_RNA|HNRPDL_uc003hms.2_RNA|HNRPDL_uc003hmt.2_Intron	NM_031372	NP_112740	O14979	HNRDL_HUMAN	heterogeneous nuclear ribonucleoprotein D-like	388	Tyr-rich.|Necessary for interaction with TNPO1.|Gly-rich.				regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|heterogeneous nuclear ribonucleoprotein complex	double-stranded DNA binding|nucleotide binding|poly(A) RNA binding|protein binding|single-stranded DNA binding			skin(1)	1		Hepatocellular(203;0.114)				TGTCCATATCCATAGTTCCCA	0.338			NA											9	95					1.58986e-06	2.00195e-06	0.008291	1	0
SEC31A	22872	broad.mit.edu	37	4	83748691	83748691	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:83748691G>A	uc003hnf.2	-	24	3286	c.3122C>T	c.(3121-3123)TCA>TTA	p.S1041L	SEC31A_uc003hnd.2_Missense_Mutation_p.S210L|SEC31A_uc003hne.2_Missense_Mutation_p.S790L|SEC31A_uc011ccl.1_Missense_Mutation_p.S987L|SEC31A_uc003hnl.2_Missense_Mutation_p.S888L|SEC31A_uc003hng.2_Missense_Mutation_p.S1026L|SEC31A_uc003hnh.2_Missense_Mutation_p.S1041L|SEC31A_uc003hni.2_Missense_Mutation_p.S927L|SEC31A_uc003hnj.2_Missense_Mutation_p.S1002L|SEC31A_uc011ccm.1_Missense_Mutation_p.S1021L|SEC31A_uc011ccn.1_Missense_Mutation_p.S1026L|SEC31A_uc003hnk.2_Missense_Mutation_p.S1002L|SEC31A_uc003hnm.2_Missense_Mutation_p.S1041L	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	1041	Interaction with PDCD6.|Pro-rich.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				TACTGGAGCTGAAGGCTGTTG	0.532			NA											13	166					0	0	0.001855	0	0
PTPN13	5783	broad.mit.edu	37	4	87643512	87643512	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:87643512G>T	uc003hpz.2	+	10	2013	c.1533G>T	c.(1531-1533)GCG>GCT	p.A511A	PTPN13_uc003hpy.2_Silent_p.A511A|PTPN13_uc003hqa.2_Silent_p.A511A|PTPN13_uc003hqb.2_Silent_p.A511A	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	511						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		CAATCAAAGCGTCCATGCTTG	0.453			NA											35	152					6.53348e-20	1.12294e-19	0.003755	1	0
DMP1	1758	broad.mit.edu	37	4	88583892	88583892	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:88583892G>T	uc003hqv.2	+	6	1066	c.962G>T	c.(961-963)AGC>ATC	p.S321I	DMP1_uc003hqw.2_Missense_Mutation_p.S305I	NM_004407	NP_004398	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1 isoform 1	321					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			pancreas(1)|skin(1)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		CAAGAAGACAGCAAGGAGAAT	0.517			NA											7	64					8.12818e-05	9.43997e-05	0.001984	1	0
DMP1	1758	broad.mit.edu	37	4	88584284	88584284	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:88584284G>T	uc003hqv.2	+	6	1458	c.1354G>T	c.(1354-1356)GAC>TAC	p.D452Y	DMP1_uc003hqw.2_Missense_Mutation_p.D436Y	NM_004407	NP_004398	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1 isoform 1	452					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			pancreas(1)|skin(1)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		TTCTGAGGAAGACGACAGTGA	0.532			NA											12	55					3.07112e-06	3.80187e-06	0.000978	1	0
PKD2	5311	broad.mit.edu	37	4	88989119	88989119	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:88989119G>A	uc003hre.2	+	13	2494	c.2428G>A	c.(2428-2430)GAT>AAT	p.D810N	PKD2_uc011cdf.1_Missense_Mutation_p.D228N|PKD2_uc011cdg.1_Missense_Mutation_p.D136N|PKD2_uc011cdh.1_Missense_Mutation_p.D33N	NM_000297	NP_000288	Q13563	PKD2_HUMAN	polycystin 2	810	Linker.|Cytoplasmic (Potential).					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			skin(1)	1		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		TCGAAGCCTGGATGACTCTGA	0.502			NA											7	54					0	0	0.001984	0	0
MMRN1	22915	broad.mit.edu	37	4	90856532	90856532	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:90856532G>A	uc003hst.2	+	6	1772	c.1701G>A	c.(1699-1701)TTG>TTA	p.L567L	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Silent_p.L309L	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	567					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TTGAAGATTTGCACATTCAAG	0.373			NA											11	64					0	0	0.008291	0	0
PDHA2	5161	broad.mit.edu	37	4	96762029	96762029	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:96762029G>T	uc003htr.3	+	1	791	c.728G>T	c.(727-729)AGG>ATG	p.R243M		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	243					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	TACTACAAGAGGGGCAATTTT	0.438			NA											24	67					5.61819e-17	9.38396e-17	0.005443	1	0
ADH6	130	broad.mit.edu	37	4	100134761	100134761	+	Splice_Site	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:100134761A>G	uc003hup.3	-	3	356	c.262_splice	c.e3+1	p.G88_splice	uc003hum.1_Intron|ADH6_uc003huo.2_Splice_Site_p.G88_splice|ADH6_uc011cef.1_Intron|ADH6_uc010ile.2_Splice_Site_p.G88_splice	NM_000672	NP_000663	P28332	ADH6_HUMAN	class V alcohol dehydrogenase isoform 2						ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	GCTAATTCCTACCTGGTTTCA	0.448			NA											16	90					0	0	0.00499	0	0
ADH1C	126	broad.mit.edu	37	4	100264205	100264205	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:100264205G>A	uc003huu.2	-	8	660	c.575C>T	c.(574-576)CCA>CTA	p.P192L		NM_000669	NP_000660	P00326	ADH1G_HUMAN	class I alcohol dehydrogenase, gamma subunit	192					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	GGTAGACCCTGGGGTGACCTA	0.428			NA							Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				44	210					0	0	0.007835	0	0
RG9MTD2	93587	broad.mit.edu	37	4	100470252	100470252	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:100470252G>C	uc003huy.2	-	8	1326	c.1013C>G	c.(1012-1014)CCA>CGA	p.P338R	RG9MTD2_uc003huz.3_Missense_Mutation_p.P338R|RG9MTD2_uc003hva.3_Missense_Mutation_p.P338R	NM_152292	NP_689505	Q8TBZ6	RG9D2_HUMAN	RNA (guanine-9-) methyltransferase domain	338							methyltransferase activity			ovary(2)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;1.7e-08)		ACATTAGTGTGGCAGAGAGTT	0.348			NA											20	100					0	0	0.010504	0	0
MTTP	4547	broad.mit.edu	37	4	100532334	100532334	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:100532334G>T	uc003hvc.3	+	14	2060	c.1804G>T	c.(1804-1806)GCT>TCT	p.A602S	MTTP_uc011cej.1_Missense_Mutation_p.A629S	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	602	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	GGAAATGGTCGCTCACAATTA	0.423			NA											16	94					3.32936e-07	4.27981e-07	0.006122	1	0
MANBA	4126	broad.mit.edu	37	4	103595107	103595107	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:103595107C>A	uc003hwg.2	-	8	1181	c.1081G>T	c.(1081-1083)GAT>TAT	p.D361Y	MANBA_uc011ces.1_Missense_Mutation_p.D304Y	NM_005908	NP_005899	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal precursor	361					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		TGGAATGAATCTGCTGGGATC	0.373			NA											15	70					5.3912e-06	6.62078e-06	0.006122	1	0
COL25A1	84570	broad.mit.edu	37	4	109738569	109738569	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:109738569G>C	uc003hze.1	-	36	2477	c.1946C>G	c.(1945-1947)CCT>CGT	p.P649R	COL25A1_uc003hzd.2_RNA	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	649	Extracellular (Potential).					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CCAACAGCCAGGCATGGGTAA	0.413			NA											5	72					0	0	0.001984	0	0
ENPEP	2028	broad.mit.edu	37	4	111441486	111441486	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:111441486C>A	uc003iab.3	+	10	2033	c.1691C>A	c.(1690-1692)CCA>CAA	p.P564Q		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	564	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	TTGTTGGACCCAAGAGCTAAC	0.418			NA											13	83					7.93312e-07	1.00717e-06	0.00245	1	0
PITX2	5308	broad.mit.edu	37	4	111554147	111554147	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:111554147G>T	uc003iad.2	-	2	590	c.8C>A	c.(7-9)ACC>AAC	p.T3N	PITX2_uc003iae.2_Missense_Mutation_p.T3N|PITX2_uc010iml.2_5'UTR|PITX2_uc003iaf.2_Missense_Mutation_p.T3N	NM_153426	NP_700475	Q99697	PITX2_HUMAN	paired-like homeodomain transcription factor 2	3					determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription factor binding				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		GCGGCAGTTGGTCTCCATTCC	0.592			NA											14	169					4.7546e-09	6.62633e-09	0.004007	1	0
ANK2	287	broad.mit.edu	37	4	114257903	114257903	+	Silent	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:114257903T>C	uc003ibe.3	+	31	3862	c.3762T>C	c.(3760-3762)GAT>GAC	p.D1254D	ANK2_uc003ibd.3_Silent_p.D1245D|ANK2_uc003ibf.3_Silent_p.D1254D|ANK2_uc011cgc.1_Silent_p.D430D|ANK2_uc003ibg.3_Silent_p.D249D|ANK2_uc011cgb.1_Silent_p.D1269D	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1221					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TTGGGGGAGATGCACCAACCT	0.388			NA											5	95					0	0	0.00308	0	0
ANK2	287	broad.mit.edu	37	4	114277294	114277294	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:114277294C>G	uc003ibe.3	+	38	7620	c.7520C>G	c.(7519-7521)TCC>TGC	p.S2507C	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Intron|ANK2_uc011cgb.1_Missense_Mutation_p.S2522C	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2474					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TCTGTGCGGTCCCGGCTACTC	0.537			NA											27	91					0	0	0.00632	0	0
NDST4	64579	broad.mit.edu	37	4	115767068	115767068	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:115767068C>A	uc003ibu.2	-	10	2705	c.2026G>T	c.(2026-2028)GCT>TCT	p.A676S	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	676	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		CGTCTTGGAGCTTCTTCCGAA	0.458			NA											21	81					0.000132079	0.000152819	0.008871	1	0
NDST4	64579	broad.mit.edu	37	4	115997603	115997603	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:115997603G>A	uc003ibu.2	-	2	1269	c.590C>T	c.(589-591)CCT>CTT	p.P197L	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	197	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		AGGAGATTGAGGGTTAACAAA	0.393			NA											19	61					0	0	0.006122	0	0
TRAM1L1	133022	broad.mit.edu	37	4	118006189	118006189	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:118006189C>G	uc003ibv.3	-	1	548	c.361G>C	c.(361-363)GAG>CAG	p.E121Q		NM_152402	NP_689615	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like	121	Cytoplasmic (Potential).|TLC.				protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)	1						TGACCAGACTCGTTAAACTTG	0.368			NA											8	61					0	0	0.004482	0	0
FAT4	79633	broad.mit.edu	37	4	126336493	126336493	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:126336493G>T	uc003ifj.3	+	5	6375	c.6375G>T	c.(6373-6375)GTG>GTT	p.V2125V	FAT4_uc011cgp.1_Silent_p.V423V	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2125	Cadherin 20.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TAACAGTGGTGGCTACAGACA	0.418			NA											19	84					6.49762e-13	1.00164e-12	0.006122	1	0
FAT4	79633	broad.mit.edu	37	4	126372972	126372972	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:126372972C>T	uc003ifj.3	+	9	10801	c.10801C>T	c.(10801-10803)CAT>TAT	p.H3601Y	FAT4_uc011cgp.1_Missense_Mutation_p.H1899Y|FAT4_uc003ifi.1_Missense_Mutation_p.H1079Y	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3601	Cadherin 34.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AGGAACTGTGCATATCACAGT	0.423			NA											15	106					0	0	0.003163	0	0
FAT4	79633	broad.mit.edu	37	4	126412741	126412741	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:126412741G>T	uc003ifj.3	+	17	14764	c.14764G>T	c.(14764-14766)GGG>TGG	p.G4922W	FAT4_uc011cgp.1_Missense_Mutation_p.G3163W|FAT4_uc003ifi.1_Missense_Mutation_p.G2399W	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4922	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CATGAAGCTAGGGCAGCAAGC	0.557			NA											11	59					5.16669e-11	7.65803e-11	0.000978	1	0
PCDH10	57575	broad.mit.edu	37	4	134073017	134073017	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:134073017C>A	uc003iha.2	+	1	2548	c.1722C>A	c.(1720-1722)ATC>ATA	p.I574I	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.I574I	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	574	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CCCCTGCCATCGTGGCGCCTC	0.677			NA											9	64					2.17888e-05	2.60114e-05	0.006214	1	0
PCDH18	54510	broad.mit.edu	37	4	138449939	138449939	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:138449939C>A	uc003ihe.3	-	2	2910	c.2523G>T	c.(2521-2523)GGG>GGT	p.G841G	PCDH18_uc003ihf.3_Silent_p.G833G|PCDH18_uc011cgz.1_Silent_p.G52G|PCDH18_uc003ihg.3_Silent_p.G620G|PCDH18_uc011cha.1_Silent_p.G21G	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	841	Cytoplasmic (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					GCTGATATTGCCCCTGGTGAA	0.408			NA											23	107					1.1804e-14	1.90746e-14	0.003954	1	0
PCDH18	54510	broad.mit.edu	37	4	138451090	138451090	+	Missense_Mutation	SNP	A	A	G	rs143055456	byFrequency	TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:138451090A>G	uc003ihe.3	-	1	2540	c.2153T>C	c.(2152-2154)GTG>GCG	p.V718A	PCDH18_uc003ihf.3_Missense_Mutation_p.V711A|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.V498A|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	718	Helical; (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					TGCAAATAGCACCATAATAAC	0.443			NA											11	83					0	0	0.008291	0	0
PCDH18	54510	broad.mit.edu	37	4	138451339	138451339	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:138451339G>T	uc003ihe.3	-	1	2291	c.1904C>A	c.(1903-1905)TCA>TAA	p.S635*	PCDH18_uc003ihf.3_Nonsense_Mutation_p.S628*|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Nonsense_Mutation_p.S415*|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	635	Cadherin 6.|Extracellular (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					GATGTCACATGATCGTGGATC	0.443			NA											16	215					1.5739e-10	2.30838e-10	0.004007	1	0
RXFP1	59350	broad.mit.edu	37	4	159568212	159568212	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:159568212G>A	uc003ipz.2	+	16	1697	c.1615G>A	c.(1615-1617)GGT>AGT	p.G539S	RXFP1_uc011cja.1_Missense_Mutation_p.G434S|RXFP1_uc010iqo.2_Missense_Mutation_p.G491S|RXFP1_uc011cjb.1_Missense_Mutation_p.G437S|RXFP1_uc010iqk.2_Missense_Mutation_p.G407S|RXFP1_uc011cjc.1_Missense_Mutation_p.G458S|RXFP1_uc011cjd.1_Missense_Mutation_p.G458S|RXFP1_uc010iql.2_Missense_Mutation_p.G383S|RXFP1_uc011cje.1_Missense_Mutation_p.G566S|RXFP1_uc010iqm.2_Missense_Mutation_p.G506S|RXFP1_uc011cjf.1_Missense_Mutation_p.G408S|RXFP1_uc010iqn.2_Missense_Mutation_p.G484S	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	539	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		TTGGATTACTGGTTTTATAGT	0.358			NA											11	59					0	0	0.008291	0	0
FSTL5	56884	broad.mit.edu	37	4	163032464	163032464	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:163032464C>A	uc003iqh.2	-	2	521	c.85G>T	c.(85-87)GGC>TGC	p.G29C	FSTL5_uc003iqi.2_Missense_Mutation_p.G29C|FSTL5_uc010iqv.2_Missense_Mutation_p.G29C	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	29						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		GATTTAAGGCCATATCCTCCT	0.408			NA											15	85					4.7546e-09	6.62633e-09	0.004007	1	0
CPE	1363	broad.mit.edu	37	4	166385731	166385731	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:166385731C>A	uc003irg.3	+	2	774	c.497C>A	c.(496-498)GCG>GAG	p.A166E		NM_001873	NP_001864	P16870	CBPE_HUMAN	carboxypeptidase E preproprotein	166					cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GAGAAGGCAGCGTCTCAGGTG	0.463			NA									OREG0016390	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	22					1.12685e-05	1.36427e-05	0.004482	1	0
DDX60L	91351	broad.mit.edu	37	4	169322029	169322029	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:169322029C>T	uc003irq.3	-	26	3660	c.3439G>A	c.(3439-3441)GTC>ATC	p.V1147I	DDX60L_uc003irr.1_Missense_Mutation_p.V1147I|DDX60L_uc003irs.1_Missense_Mutation_p.V842I	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1147							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		ATTGCAAAGACATAACTATGA	0.368			NA											9	57					0	0	0.004482	0	0
HAND2	9464	broad.mit.edu	37	4	174448523	174448523	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:174448523C>T	uc003ith.1	-	2	1497	c.559G>A	c.(559-561)GAA>AAA	p.E187K	HAND2_uc003itg.1_Missense_Mutation_p.R152Q	NM_021973	NP_068808	P61296	HAND2_HUMAN	basic helix-loop-helix transcription factor	187					adult heart development|angiogenesis|apoptosis|cardiac neural crest cell development involved in outflow tract morphogenesis|heart looping|in utero embryonic development|negative regulation of cardiac muscle cell apoptosis|noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|regulation of secondary heart field cardioblast proliferation|thymus development	nuclear chromatin|transcription factor complex	activating transcription factor binding|protein homodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity			skin(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.37e-18)|Epithelial(43;5.5e-17)|OV - Ovarian serous cystadenocarcinoma(60;3.3e-10)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		TTCAAGATTTCGTTCTGGACA	0.547			NA											9	137					0	0	0.004482	0	0
ASB5	140458	broad.mit.edu	37	4	177142722	177142722	+	Silent	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:177142722A>T	uc003iuq.1	-	4	430	c.414T>A	c.(412-414)ACT>ACA	p.T138T	ASB5_uc003iup.1_Silent_p.T85T	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	138	ANK 3.				intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		TGAATAACGGAGTCACGCCAT	0.458			NA											14	35					0	0	0.00245	0	0
ODZ3	55714	broad.mit.edu	37	4	183522166	183522166	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:183522166A>T	uc003ivd.1	+	3	638	c.601A>T	c.(601-603)ACT>TCT	p.T201S		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	201	Cytoplasmic (Potential).|Teneurin N-terminal.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TCCATCCATCACTTCTCTCAA	0.562			NA											19	193					0	0	0.002299	0	0
ODZ3	55714	broad.mit.edu	37	4	183676381	183676381	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:183676381A>G	uc003ivd.1	+	21	4898	c.4861A>G	c.(4861-4863)AGT>GGT	p.S1621G	ODZ3_uc003ive.1_Missense_Mutation_p.S1034G	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1621	YD 3.|Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		AGCCACTAAAAGTGATGAAAC	0.313			NA											3	33					0	0	0.004672	0	0
STOX2	56977	broad.mit.edu	37	4	184930348	184930348	+	Silent	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:184930348G>C	uc003ivz.1	+	3	1792	c.357G>C	c.(355-357)ACG>ACC	p.T119T	STOX2_uc003iwa.1_5'UTR	NM_020225	NP_064610	Q9P2F5	STOX2_HUMAN	storkhead box 2	119					embryo development|maternal placenta development						0		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		TGCGGCACACGCTGAACACGC	0.438			NA											4	19					0	0	0.009096	0	0
FAT1	2195	broad.mit.edu	37	4	187527368	187527368	+	Splice_Site	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:187527368C>G	uc003izf.2	-	17	10395	c.10207_splice	c.e17-1	p.I3403_splice		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor						actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						AACCTGAAATCTTTTCAGGCA	0.507	Colon(197;1040 2055 4143 4984 49344)		NA								HNSCC(5;0.00058)			5	40					0	0	0.000602	0	0
TRIML2	205860	broad.mit.edu	37	4	189012860	189012860	+	Silent	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:189012860C>G	uc003izl.2	-	7	867	c.831G>C	c.(829-831)GCG>GCC	p.A277A	TRIML2_uc003izj.1_Silent_p.A105A|TRIML2_uc003izk.1_Silent_p.A85A|TRIML2_uc011cle.1_Silent_p.A352A	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	277	B30.2/SPRY.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		TGCTGCCCTTCGCGTCTGCAG	0.617			NA											19	175					0	0	0.008871	0	0
TRIML1	339976	broad.mit.edu	37	4	189061043	189061043	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:189061043G>T	uc003izm.1	+	1	446	c.331G>T	c.(331-333)GGT>TGT	p.G111C		NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	111					multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		TGACGAGCAGGGTGGAAGCGC	0.622	Melanoma(31;213 1036 16579 23968 32372)		NA											4	22					0.00909568	0.00983662	0.009096	1	0
TRIML1	339976	broad.mit.edu	37	4	189068295	189068295	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr4:189068295G>T	uc003izm.1	+	6	1291	c.1176G>T	c.(1174-1176)TCG>TCT	p.S392S	TRIML1_uc003izn.1_Silent_p.S116S	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	392	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		TCTGGGTCTCGTCACCTTTGA	0.493	Melanoma(31;213 1036 16579 23968 32372)		NA											34	109					1.26612e-14	2.0417e-14	0.003271	1	0
TRIP13	9319	broad.mit.edu	37	5	916038	916038	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:916038G>T	uc003jbr.2	+	12	1263	c.1153G>T	c.(1153-1155)GGC>TGC	p.G385C		NM_004237	NP_004228	Q15645	PCH2_HUMAN	thyroid hormone receptor interactor 13	385					double-strand break repair|reciprocal meiotic recombination|synaptonemal complex assembly|transcription from RNA polymerase II promoter		ATP binding|identical protein binding|nucleoside-triphosphatase activity|transcription cofactor activity				0			Epithelial(17;0.00147)|OV - Ovarian serous cystadenocarcinoma(19;0.00271)|all cancers(22;0.00622)|Lung(60;0.165)			GGGCCTCAGCGGCCGGGTCCT	0.542			NA											14	306					2.61681e-11	3.89738e-11	0.00245	1	0
IRX1	79192	broad.mit.edu	37	5	3599391	3599391	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:3599391C>G	uc003jde.2	+	2	381	c.329C>G	c.(328-330)GCA>GGA	p.A110G		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	110						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						GCCACCTTCGCAGCCCACACG	0.587			NA											4	84					0	0	0.009096	0	0
PAPD7	11044	broad.mit.edu	37	5	6742603	6742603	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:6742603G>T	uc003jdx.1	+	5	388	c.259G>T	c.(259-261)GTA>TTA	p.V87L	PAPD7_uc011cmn.1_Missense_Mutation_p.V78L	NM_006999	NP_008930	Q5XG87	PAPD7_HUMAN	DNA polymerase sigma	87					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			ovary(1)	1						ATCTTTACAGGTACCAATAAT	0.428	NSCLC(7;212 333 5667 23379 46547)		NA											15	32					1.99824e-07	2.59686e-07	0.00499	1	0
ADCY2	108	broad.mit.edu	37	5	7520898	7520898	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:7520898C>T	uc003jdz.1	+	3	523	c.456C>T	c.(454-456)CCC>CCT	p.P152P		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	152	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CCATGCTGCCCTTCAACATGC	0.522			NA											6	124					0	0	0.001168	0	0
SEMA5A	9037	broad.mit.edu	37	5	9066613	9066613	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:9066613G>T	uc003jek.2	-	17	2931	c.2219C>A	c.(2218-2220)CCG>CAG	p.P740Q		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	740	TSP type-1 4.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						CAGCAAATTCGGATCAGCCAG	0.557			NA											52	165					1.4374e-25	2.59203e-25	0.00361	1	0
CCT5	22948	broad.mit.edu	37	5	10258573	10258573	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:10258573G>T	uc003jeq.2	+	6	970	c.799G>T	c.(799-801)GAT>TAT	p.D267Y	CCT5_uc011cmq.1_Missense_Mutation_p.D114Y|CCT5_uc003jer.2_Missense_Mutation_p.D267Y|CCT5_uc010its.2_Missense_Mutation_p.D267Y|CCT5_uc011cmr.1_Missense_Mutation_p.D212Y|CCT5_uc011cms.1_Missense_Mutation_p.D229Y|CCT5_uc011cmt.1_Missense_Mutation_p.D174Y	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	267					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						GCATAAGCTGGATGTGACCTC	0.393			NA											9	93					0.00448238	0.00488872	0.004482	1	0
CTNND2	1501	broad.mit.edu	37	5	11236895	11236895	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:11236895G>C	uc003jfa.1	-	10	1814	c.1669C>G	c.(1669-1671)CAG>GAG	p.Q557E	CTNND2_uc010itt.2_Missense_Mutation_p.Q466E|CTNND2_uc011cmy.1_Missense_Mutation_p.Q220E|CTNND2_uc011cmz.1_Missense_Mutation_p.Q124E|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.Q124E	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	557	ARM 2.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TGCAACATCTGAATCACTTCC	0.483			NA											52	118					0	0	0.00361	0	0
CDH18	1016	broad.mit.edu	37	5	19747068	19747068	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:19747068G>T	uc003jgc.2	-	3	883	c.506C>A	c.(505-507)CCT>CAT	p.P169H	CDH18_uc003jgd.2_Missense_Mutation_p.P169H|CDH18_uc011cnm.1_Missense_Mutation_p.P169H	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	169	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TGACATTTCAGGCACAGTAAC	0.328			NA											32	101					3.86903e-22	6.7785e-22	0.002836	1	0
CDH12	1010	broad.mit.edu	37	5	21854810	21854810	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:21854810G>T	uc010iuc.2	-	4	1074	c.616C>A	c.(616-618)CAA>AAA	p.Q206K	CDH12_uc011cno.1_Intron|CDH12_uc003jgk.2_Missense_Mutation_p.Q206K	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	206	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						AAATAAGGTTGTCCCTGAAGA	0.393			NA								HNSCC(59;0.17)			29	59					2.65835e-16	4.40673e-16	0.007291	1	0
CDH12	1010	broad.mit.edu	37	5	21975201	21975201	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:21975201C>A	uc010iuc.2	-	3	983	c.525G>T	c.(523-525)GTG>GTT	p.V175V	CDH12_uc011cno.1_Silent_p.V175V|CDH12_uc003jgk.2_Silent_p.V175V	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	175	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						CCTACTCACCCACAGGAGACA	0.358			NA								HNSCC(59;0.17)			57	116					4.83677e-39	9.17319e-39	0.00361	1	0
PRDM9	56979	broad.mit.edu	37	5	23526486	23526486	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:23526486C>A	uc003jgo.2	+	11	1471	c.1289C>A	c.(1288-1290)CCC>CAC	p.P430H		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	430					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CCAGAGAATCCCTGCCCAGGG	0.453			NA								HNSCC(3;0.000094)			46	114					2.51966e-14	4.0127e-14	0.00361	1	0
CDH10	1008	broad.mit.edu	37	5	24491822	24491822	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:24491822C>G	uc003jgr.1	-	11	2071	c.1739G>C	c.(1738-1740)GGC>GCC	p.G580A	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	580	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GGTCAGTGTGCCTGTGCTGCT	0.498			NA								HNSCC(23;0.051)			13	81					0	0	0.00245	0	0
CDH10	1008	broad.mit.edu	37	5	24537761	24537761	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:24537761C>A	uc003jgr.1	-	3	586	c.254G>T	c.(253-255)GGA>GTA	p.G85V	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	85	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TGATCCATCTCCTTTATCTTG	0.363			NA								HNSCC(23;0.051)			11	57					3.07112e-06	3.80187e-06	0.000978	1	0
CDH9	1007	broad.mit.edu	37	5	26881389	26881389	+	Silent	SNP	C	C	T	rs147182231		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:26881389C>T	uc003jgs.1	-	12	2395	c.2226G>A	c.(2224-2226)GGG>GGA	p.G742G	CDH9_uc011cnv.1_Silent_p.G335G	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	742	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.G742G(1)		ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TGGAATCATTCCCTTCATAGG	0.418	Melanoma(8;187 585 15745 40864 52829)		NA											6	130					0	0	0.001984	0	0
NPR3	4883	broad.mit.edu	37	5	32712561	32712561	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:32712561G>T	uc003jhv.2	+	1	897	c.679G>T	c.(679-681)GAG>TAG	p.E227*	NPR3_uc010iuo.2_Intron|NPR3_uc011cnz.1_Intron|NPR3_uc003jhu.2_Nonsense_Mutation_p.E227*	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	227	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	CTTCCAGGAGGAGGGTTTGCA	0.587			NA											12	112					2.80697e-09	3.93692e-09	0.000978	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33658332	33658332	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:33658332C>A	uc003jia.1	-	7	1310	c.1147G>T	c.(1147-1149)GGA>TGA	p.G383*	ADAMTS12_uc010iuq.1_Nonsense_Mutation_p.G383*	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	383	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						AGAGGGAGTCCCGAATCTTCA	0.507			NA								HNSCC(64;0.19)			43	148					5.59293e-11	8.26594e-11	0.006999	1	0
IL7R	3575	broad.mit.edu	37	5	35876290	35876290	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:35876290T>A	uc003jjs.2	+	8	1171	c.1082T>A	c.(1081-1083)TTT>TAT	p.F361Y	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	361	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			CCAGAAAGCTTTGGAAGAGAT	0.532			NA											16	66					0	0	0.004007	0	0
C5orf42	65250	broad.mit.edu	37	5	37162576	37162576	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:37162576T>C	uc011cpa.1	-	38	7912	c.7681A>G	c.(7681-7683)ACA>GCA	p.T2561A	C5orf42_uc011coy.1_Missense_Mutation_p.T1061A|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.T1636A	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2561										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			CCTGGGTCTGTATTTGTACTT	0.299			NA											29	77					0	0	0.007291	0	0
EGFLAM	133584	broad.mit.edu	37	5	38370546	38370546	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:38370546G>A	uc003jlc.1	+	6	1018	c.694G>A	c.(694-696)GAC>AAC	p.D232N	EGFLAM_uc003jlb.1_Missense_Mutation_p.D232N	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	232	Fibronectin type-III 2.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					CTGGCCCAGTGACATCATCCG	0.577	Colon(62;485 1295 3347 17454)		NA											4	55					0	0	0.009096	0	0
FYB	2533	broad.mit.edu	37	5	39202684	39202684	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:39202684G>T	uc003jls.2	-	1	446	c.379C>A	c.(379-381)CCT>ACT	p.P127T	FYB_uc003jlt.2_Missense_Mutation_p.P127T|FYB_uc003jlu.2_Missense_Mutation_p.P127T|FYB_uc011cpl.1_Missense_Mutation_p.P137T	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	127					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			GGAAATGTAGGTTTGGAATCT	0.522			NA											12	163					9.31168e-06	1.1336e-05	0.001855	1	0
HEATR7B2	133558	broad.mit.edu	37	5	41010120	41010120	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:41010120C>T	uc003jmj.3	-	31	3687	c.3197G>A	c.(3196-3198)AGT>AAT	p.S1066N	HEATR7B2_uc003jmi.3_Missense_Mutation_p.S621N	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1066							binding			ovary(6)|central_nervous_system(2)	8						GAACTGAAAACTTTCTTCTTT	0.408			NA											19	69					0	0	0.007413	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41045869	41045869	+	Nonsense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:41045869G>C	uc003jmj.3	-	18	2305	c.1815C>G	c.(1813-1815)TAC>TAG	p.Y605*	HEATR7B2_uc003jmi.3_Nonsense_Mutation_p.Y160*	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	605	HEAT 7.						binding			ovary(6)|central_nervous_system(2)	8						AGTTATTGCTGTAACTGCCCA	0.333			NA											57	210					0	0	0.00361	0	0
ELOVL7	79993	broad.mit.edu	37	5	60053392	60053392	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:60053392C>A	uc003jsi.3	-	8	780	c.580G>T	c.(580-582)GGG>TGG	p.G194W	ELOVL7_uc011cqo.1_Missense_Mutation_p.G107W|ELOVL7_uc010iwk.2_Missense_Mutation_p.G194W|ELOVL7_uc003jsj.3_Missense_Mutation_p.G181W	NM_024930	NP_079206	A1L3X0	ELOV7_HUMAN	elongation of very long chain fatty acids-like	194	Helical; (Potential).				fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0		Lung NSC(810;2.56e-06)|Prostate(74;0.0115)|Breast(144;0.0244)|Ovarian(174;0.0481)				TAGGCTGGCCCCAATGCAGAA	0.363			NA											16	43					6.94344e-10	9.98404e-10	0.006122	1	0
HTR1A	3350	broad.mit.edu	37	5	63256918	63256918	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:63256918A>T	uc011cqt.1	-	1	629	c.629T>A	c.(628-630)CTC>CAC	p.L210H		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	210	Helical; Name=5; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	AACCAGCATGAGCAGCAGCGG	0.577			NA											68	126					0	0	0.00361	0	0
CWC27	10283	broad.mit.edu	37	5	64082413	64082413	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:64082413A>C	uc003jtn.1	+	6	777	c.558A>C	c.(556-558)AAA>AAC	p.K186N	CWC27_uc003jtl.2_Missense_Mutation_p.K186N|CWC27_uc003jtm.2_Missense_Mutation_p.K186N|CWC27_uc010iwt.1_Missense_Mutation_p.K186N	NM_005869	NP_005860	Q6UX04	CWC27_HUMAN	serologically defined colon cancer antigen 10	186					protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity				0						AAAAAGAGAAACCAGAGGAGG	0.303			NA											3	19					0	0	0.000602	0	0
NLN	57486	broad.mit.edu	37	5	65084126	65084126	+	Silent	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:65084126C>G	uc003juf.2	+	8	1256	c.1140C>G	c.(1138-1140)CTC>CTG	p.L380L	NLN_uc003jue.2_Silent_p.L380L|NLN_uc003jug.2_Silent_p.L209L|NLN_uc010iww.2_Silent_p.L75L	NM_020726	NP_065777	Q9BYT8	NEUL_HUMAN	neurolysin precursor	380					proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)		AAGAGTTCCTCAAGGAATACT	0.418			NA											27	109					0	0	0.005443	0	0
CD180	4064	broad.mit.edu	37	5	66479590	66479590	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:66479590G>A	uc003juy.2	-	3	1229	c.1081C>T	c.(1081-1083)CTT>TTT	p.L361F		NM_005582	NP_005573	Q99467	CD180_HUMAN	CD180 molecule precursor	361	LRR 11.|Extracellular (Potential).				inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			ovary(1)	1		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		CCAACACCAAGGTGAAGTTTC	0.433			NA											35	82					0	0	0.003271	0	0
PDE8B	8622	broad.mit.edu	37	5	76721722	76721722	+	Splice_Site	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:76721722G>T	uc003kfa.2	+	21	2593	c.2548_splice	c.e21+1	p.A850_splice	PDE8B_uc003kfb.2_Splice_Site_p.A830_splice|PDE8B_uc003kfc.2_Splice_Site_p.A795_splice|PDE8B_uc003kfd.2_Splice_Site_p.A803_splice|PDE8B_uc003kfe.2_Splice_Site_p.A753_splice	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1						cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		GCTTGGGATGGTAAGACAGTT	0.378			NA											5	44					5.9392e-07	7.59035e-07	0.001168	1	0
CMYA5	202333	broad.mit.edu	37	5	79030273	79030273	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:79030273G>T	uc003kgc.2	+	2	5757	c.5685G>T	c.(5683-5685)ATG>ATT	p.M1895I		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1895						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AAAACTGGATGTTGGGAAAGC	0.433			NA											25	34					1.88708e-17	3.17955e-17	0.008361	1	0
VCAN	1462	broad.mit.edu	37	5	82815315	82815315	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:82815315C>G	uc003kii.3	+	7	1546	c.1190C>G	c.(1189-1191)CCC>CGC	p.P397R	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.P397R|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	397	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GAGTTCCCTCCCGTGGGAAAT	0.433			NA											30	96					0	0	0.009535	0	0
MBLAC2	153364	broad.mit.edu	37	5	89756990	89756990	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:89756990C>A	uc003kjp.2	-	2	1310	c.834G>T	c.(832-834)TCG>TCT	p.S278S		NM_203406	NP_981951	Q68D91	MBLC2_HUMAN	beta-lactamase-like	278							hydrolase activity|metal ion binding				0						GATACTAGGGCGAGGTCCTAG	0.318			NA											7	10					0.00307968	0.0033804	0.00308	1	0
PPIP5K2	23262	broad.mit.edu	37	5	102469323	102469323	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:102469323G>A	uc003kod.3	+	3	800	c.281G>A	c.(280-282)TGT>TAT	p.C94Y	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Missense_Mutation_p.C94Y|PPIP5K2_uc010jbo.1_Intron	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	94					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2						TGGCCTTTATGTGATTGTCTT	0.294			NA											22	67					0	0	0.00333	0	0
MCC	4163	broad.mit.edu	37	5	112437459	112437459	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:112437459C>A	uc003kqj.3	-	6	1335	c.805G>T	c.(805-807)GAG>TAG	p.E269*	MCC_uc003kqk.3_RNA|MCC_uc003kql.3_Nonsense_Mutation_p.E459*|MCC_uc011cwb.1_Nonsense_Mutation_p.E269*|MCC_uc010jcd.1_Nonsense_Mutation_p.E231*	NM_002387	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 2	269					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		CGGTCCCGCTCTTCCCGGATG	0.602			NA											27	61					1.32003e-05	1.5894e-05	0.005443	1	0
LMNB1	4001	broad.mit.edu	37	5	126156789	126156789	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:126156789G>C	uc003kud.1	+	7	1716	c.1348G>C	c.(1348-1350)GAT>CAT	p.D450H	LMNB1_uc010jdb.1_RNA|LMNB1_uc011cxb.1_Missense_Mutation_p.D240H	NM_005573	NP_005564	P20700	LMNB1_HUMAN	lamin B1	450	Tail.				cellular component disassembly involved in apoptosis	lamin filament|nuclear inner membrane	protein binding|structural molecule activity			kidney(1)|central_nervous_system(1)	2		all_cancers(142;0.103)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.033)|OV - Ovarian serous cystadenocarcinoma(64;0.0398)|all cancers(49;0.0903)		AATTGATGTTGATGGGAAATT	0.408			NA											15	63					0	0	0.00499	0	0
SLC12A2	6558	broad.mit.edu	37	5	127487036	127487036	+	Silent	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:127487036A>T	uc003kus.2	+	14	2375	c.2211A>T	c.(2209-2211)CTA>CTT	p.L737L	SLC12A2_uc010jdf.2_RNA|SLC12A2_uc010jdg.2_Silent_p.L737L	NM_001046	NP_001037	P55011	S12A2_HUMAN	solute carrier family 12	737	Helical; (Potential).				potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	CTGCATTGCTAACATATGTGA	0.383			NA											20	67					0	0	0.007413	0	0
FBN2	2201	broad.mit.edu	37	5	127622515	127622515	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:127622515G>T	uc003kuu.2	-	55	7346	c.6907C>A	c.(6907-6909)CAC>AAC	p.H2303N		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2303	EGF-like 39; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCACAGTCGTGTAACCCTTCA	0.438			NA											12	49					2.61681e-11	3.89738e-11	0.00245	1	0
RAPGEF6	51735	broad.mit.edu	37	5	130828276	130828276	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:130828276T>A	uc003kvn.1	-	14	1936	c.1730A>T	c.(1729-1731)CAG>CTG	p.Q577L	RAPGEF6_uc003kvp.1_Missense_Mutation_p.Q627L|RAPGEF6_uc003kvo.1_Missense_Mutation_p.Q577L|RAPGEF6_uc010jdi.1_Missense_Mutation_p.Q577L|RAPGEF6_uc010jdj.1_Missense_Mutation_p.Q577L|RAPGEF6_uc003kvq.2_Missense_Mutation_p.Q294L|RAPGEF6_uc003kvr.2_Missense_Mutation_p.Q577L|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.Q577L	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	577	PDZ.				Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		TTTCCTTACCTGATCACCACG	0.403	Melanoma(168;435 1955 13113 13877 23213)		NA											29	59					0	0	0.009535	0	0
RAD50	10111	broad.mit.edu	37	5	131895051	131895051	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:131895051G>T	uc003kxi.2	+	2	592	c.205G>T	c.(205-207)GAT>TAT	p.D69Y	RAD50_uc003kxg.1_5'UTR|RAD50_uc003kxh.2_5'UTR	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	69					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATTTGTACACGATCCCAAGGT	0.214			NA						Homologous_recombination					31	80					1.06801e-11	1.60462e-11	0.009535	1	0
KLHL3	26249	broad.mit.edu	37	5	136964068	136964068	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:136964068C>A	uc010jek.2	-	13	1953	c.1509G>T	c.(1507-1509)GTG>GTT	p.V503V	KLHL3_uc011cyc.1_Silent_p.V238V|KLHL3_uc003lbr.3_Silent_p.V421V|KLHL3_uc011cyd.1_RNA	NM_017415	NP_059111	Q9UH77	KLHL3_HUMAN	kelch-like 3	503	Kelch 5.					cytoplasm|cytoskeleton	actin binding|structural molecule activity				0		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		CGCTCTTCCTCACCAAAGGCC	0.552			NA											14	157					1.3612e-06	1.72248e-06	0.003163	1	0
NRG2	9542	broad.mit.edu	37	5	139231342	139231342	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:139231342G>A	uc003lex.1	-	9	1844	c.1619C>T	c.(1618-1620)TCA>TTA	p.S540L	NRG2_uc003lev.1_Missense_Mutation_p.S548L|NRG2_uc003lew.1_Missense_Mutation_p.S542L|NRG2_uc003ley.1_Missense_Mutation_p.S534L	NM_004883	NP_004874	O14511	NRG2_HUMAN	neuregulin 2 isoform 1	540	Cytoplasmic (Potential).				embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			pancreas(2)|breast(2)|ovary(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCCACTGATGATAGCATGAT	0.632			NA											6	48					0	0	0.001984	0	0
PCDHB2	56133	broad.mit.edu	37	5	140476226	140476226	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:140476226G>T	uc003lil.2	+	1	1990	c.1852G>T	c.(1852-1854)GGC>TGC	p.G618C	PCDHB2_uc003lim.1_Missense_Mutation_p.G279C	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	618	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGGCTGTTCGGCGTGTGGGC	0.687			NA											17	52					1.10923e-09	1.5773e-09	0.00278	1	0
PCDHB7	56129	broad.mit.edu	37	5	140552728	140552728	+	Silent	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:140552728G>C	uc003lit.2	+	1	486	c.312G>C	c.(310-312)CTG>CTC	p.L104L		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	104	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTGTGTGCTGCCTTTCCAGT	0.443			NA											30	79					0	0	0.009535	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140745190	140745190	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:140745190C>A	uc003lju.1	+	1	1293	c.1293C>A	c.(1291-1293)CCC>CCA	p.P431P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Silent_p.P431P	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	431	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAACCCCGCCCCTCTCTACAG	0.448			NA											31	78					4.16155e-14	6.59339e-14	0.00874	1	0
PCDHGA7	56108	broad.mit.edu	37	5	140763276	140763276	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:140763276C>A	uc003lka.1	+	1	810	c.810C>A	c.(808-810)GAC>GAA	p.D270E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.D270E	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	270	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGACCTGGACGAGGGAGTCA	0.463			NA											5	39					0.000602214	0.000674971	0.000602	1	0
PCDHGA7	56108	broad.mit.edu	37	5	140764644	140764644	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:140764644G>T	uc003lka.1	+	1	2178	c.2178G>T	c.(2176-2178)CAG>CAT	p.Q726H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGB4_uc003lkc.1_5'Flank|PCDHGA7_uc003ljz.1_Missense_Mutation_p.Q726H|PCDHGB4_uc011dav.1_5'Flank	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	726	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCTGCTGCAGGCTTCAGAAG	0.632			NA											12	45					2.27111e-07	2.94651e-07	0.001368	1	0
PCDHGA8	9708	broad.mit.edu	37	5	140773763	140773763	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:140773763C>G	uc003lkd.1	+	1	2281	c.1383C>G	c.(1381-1383)ATC>ATG	p.I461M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.I461M	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	461	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCGTATATCCTAGAGAACA	0.527			NA											9	20					0	0	0.008291	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140799740	140799740	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:140799740G>C	uc003lkn.1	+	1	2459	c.2314G>C	c.(2314-2316)GAT>CAT	p.D772H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Missense_Mutation_p.D772H|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	772	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACATCTGTTGATCATTGTCC	0.418			NA											9	55					0	0	0.006214	0	0
PCDH1	5097	broad.mit.edu	37	5	141236969	141236969	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:141236969T>A	uc003llp.2	-	4	3284	c.3167A>T	c.(3166-3168)CAC>CTC	p.H1056L		NM_032420	NP_115796	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 2 precursor	Error:Variant_position_missing_in_Q08174_after_alignment					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		ATAGTAACTGTGCTGGGATGG	0.617	Ovarian(132;1609 1739 4190 14731 45037)		NA											8	24					0	0	0.00308	0	0
SLC36A1	206358	broad.mit.edu	37	5	150858948	150858948	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:150858948G>T	uc003luc.2	+	10	1274	c.1057G>T	c.(1057-1059)GTC>TTC	p.V353F	GM2A_uc011dcs.1_Intron|SLC36A1_uc003lub.1_Missense_Mutation_p.V353F|SLC36A1_uc010jhw.1_Missense_Mutation_p.V353F	NM_078483	NP_510968	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 member 1	353	Helical; Name=8; (Potential).				cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			skin(1)	1		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	CCAGTTCTACGTCCCGGCTGA	0.547	Melanoma(151;1534 1860 12947 32979 37872)		NA											24	62					2.70639e-06	3.36932e-06	0.002299	1	0
SPARC	6678	broad.mit.edu	37	5	151054176	151054176	+	Silent	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:151054176A>T	uc003luh.2	-	2	141	c.117T>A	c.(115-117)ACT>ACA	p.T39T	GM2A_uc011dcs.1_Intron|SPARC_uc003lug.2_5'UTR|SPARC_uc003lui.2_Silent_p.T39T|uc003luj.2_5'Flank	NM_003118	NP_003109	P09486	SPRC_HUMAN	secreted protein, acidic, cysteine-rich	39	Asp/Glu-rich (acidic; binds calcium).				ossification|platelet activation|platelet degranulation|signal transduction	basement membrane|extracellular space|platelet alpha granule lumen	calcium ion binding|collagen binding			central_nervous_system(1)	1		Medulloblastoma(196;0.109)|all_hematologic(541;0.122)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;0.00118)	Becaplermin(DB00102)	CACATACCTCAGTCACCTCTG	0.542			NA											44	89					0	0	0.002522	0	0
NMUR2	56923	broad.mit.edu	37	5	151784225	151784225	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:151784225G>A	uc003luv.2	-	1	616	c.450C>T	c.(448-450)CAC>CAT	p.H150H		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	150	Cytoplasmic (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(3)|skin(2)|lung(1)|breast(1)|pancreas(1)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			CGCGGAACGGGTGTAGGATGG	0.642			NA											12	57					0	0	0.001368	0	0
GRIA1	2890	broad.mit.edu	37	5	153077700	153077700	+	Missense_Mutation	SNP	G	G	T	rs147418341		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:153077700G>T	uc003lva.3	+	9	1596	c.1231G>T	c.(1231-1233)GTC>TTC	p.V411F	GRIA1_uc003luy.3_Missense_Mutation_p.V411F|GRIA1_uc003luz.3_Missense_Mutation_p.V316F|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.V331F|GRIA1_uc011dcx.1_Missense_Mutation_p.V342F|GRIA1_uc011dcy.1_Missense_Mutation_p.V421F|GRIA1_uc011dcz.1_Missense_Mutation_p.V421F|GRIA1_uc010jia.1_Missense_Mutation_p.V391F	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	411	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AACATACATCGTCACAACAAT	0.473			NA											11	21					3.07112e-06	3.80187e-06	0.000978	1	0
LARP1	23367	broad.mit.edu	37	5	154181811	154181811	+	Missense_Mutation	SNP	G	G	T	rs145327227		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:154181811G>T	uc003lvp.2	+	11	2390	c.1961G>T	c.(1960-1962)CGC>CTC	p.R654L	LARP1_uc003lvo.2_Missense_Mutation_p.R577L|LARP1_uc010jie.1_Missense_Mutation_p.R449L	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	654							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CATTACATGCGCCGGCACCCA	0.537			NA											21	58					1.64293e-13	2.56865e-13	0.00333	1	0
ADAM19	8728	broad.mit.edu	37	5	156964958	156964958	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:156964958G>A	uc003lwz.2	-	4	357	c.293C>T	c.(292-294)TCA>TTA	p.S98L	ADAM19_uc003lww.1_5'UTR|ADAM19_uc011ddr.1_Missense_Mutation_p.S29L	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	98					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTTACCACTTGAAGTATAATG	0.448			NA											8	134					0	0	0.006214	0	0
SLIT3	6586	broad.mit.edu	37	5	168151447	168151447	+	Silent	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:168151447C>G	uc003mab.2	-	21	2733	c.2313G>C	c.(2311-2313)CTG>CTC	p.L771L	SLIT3_uc010jjg.2_Silent_p.L771L	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	771	LRR 17.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGAGGGCGGACAGCTCTCTGG	0.502	Ovarian(29;311 847 10864 17279 24903)		NA											4	55					0	0	0.001984	0	0
C5orf58	133874	broad.mit.edu	37	5	169672990	169672990	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:169672990A>G	uc010jjn.2	+	4	265	c.182A>G	c.(181-183)GAC>GGC	p.D61G	C5orf58_uc003mal.2_Intron	NM_001102609	NP_001096079	C9J3I9	CE058_HUMAN	hypothetical protein LOC133874	61											0						TTGCTTTGTGACCTTATCCTA	0.348			NA											14	169					0	0	0.00499	0	0
FGF18	8817	broad.mit.edu	37	5	170883614	170883614	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:170883614G>A	uc003mbk.2	+	5	966	c.429G>A	c.(427-429)TCG>TCA	p.S143S		NM_003862	NP_003853	O76093	FGF18_HUMAN	fibroblast growth factor 18 precursor	143					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell proliferation	extracellular space|nucleolus	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CCCTGATGTCGGCTAAGTACT	0.587			NA											14	97					0	0	0.003163	0	0
STC2	8614	broad.mit.edu	37	5	172753012	172753012	+	Silent	SNP	C	C	T	rs145449570	byFrequency	TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:172753012C>T	uc003mco.1	-	2	1463	c.153G>A	c.(151-153)GCG>GCA	p.A51A	STC2_uc003mcn.1_5'UTR	NM_003714	NP_003705	O76061	STC2_HUMAN	stanniocalcin 2 precursor	51					cell surface receptor linked signaling pathway|cell-cell signaling	extracellular region	hormone activity			skin(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.223)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GCTGGATCTCCGCTAAAAGGA	0.413			NA											41	107					0	0	0.009718	0	0
DRD1	1812	broad.mit.edu	37	5	174869611	174869611	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:174869611G>T	uc003mcz.2	-	2	1437	c.492C>A	c.(490-492)CAC>CAA	p.H164Q		NM_000794	NP_000785	P21728	DRD1_HUMAN	dopamine receptor D1	164	Extracellular (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			ovary(2)|skin(1)	3	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	GTTTTGCCTTGTGCCAGCTGA	0.527			NA											27	66					1.42536e-11	2.13942e-11	0.004656	1	0
CPLX2	10814	broad.mit.edu	37	5	175306929	175306929	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:175306929C>G	uc003mde.1	+	5	632	c.286C>G	c.(286-288)CGG>GGG	p.R96G	CPLX2_uc003mdf.1_Missense_Mutation_p.R96G	NM_006650	NP_006641	Q6PUV4	CPLX2_HUMAN	complexin 2	96	Interaction with the SNARE complex (By similarity).				mast cell degranulation|positive regulation of synaptic plasticity|vesicle docking involved in exocytosis	cytosol				ovary(1)	1	all_cancers(89;0.004)|Renal(175;0.000269)|Lung NSC(126;0.00441)|all_lung(126;0.00747)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GAGCCTGACCCGGCCCAAGAA	0.652			NA											12	20					0	0	0.00245	0	0
C5orf25	375484	broad.mit.edu	37	5	175751758	175751758	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:175751758G>C	uc003mds.3	+	9	2519	c.2112G>C	c.(2110-2112)CAG>CAC	p.Q704H	C5orf25_uc003mdt.3_Missense_Mutation_p.Q289H|C5orf25_uc003mdr.3_RNA|C5orf25_uc003mdv.2_Missense_Mutation_p.Q165H			Q8NDZ2	CE025_HUMAN	RecName: Full=Uncharacterized protein C5orf25;	704											0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)		AGAGGAGCCAGAGGTGAGTCT	0.398			NA											3	5					0	0	0.009096	0	0
TMED9	54732	broad.mit.edu	37	5	177019267	177019267	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:177019267C>T	uc003mhx.2	+	1	55	c.52C>T	c.(52-54)CTG>TTG	p.L18L	TMED9_uc010jko.2_RNA	NM_017510	NP_059980	Q9BVK6	TMED9_HUMAN	transmembrane emp24 protein transport domain	18					transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane					0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGGAACCGGGCTGGGTAGAGT	0.682			NA											4	7					0	0	0.000602	0	0
HNRNPH1	3187	broad.mit.edu	37	5	179050070	179050070	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:179050070C>T	uc003mkf.3	-	2	171	c.65G>A	c.(64-66)TGC>TAC	p.C22Y	HNRNPH1_uc003mkg.3_5'UTR|HNRNPH1_uc003mke.3_Missense_Mutation_p.C22Y|HNRNPH1_uc003mkh.3_Missense_Mutation_p.C22Y	NM_005520	NP_005511	P31943	HNRH1_HUMAN	heterogeneous nuclear ribonucleoprotein H1	22	RRM 1.				regulation of RNA splicing	actin cytoskeleton|catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|poly(U) RNA binding|protein binding				0						ATCGGCCGAGCAAGACCAGGG	0.473			NA											18	41					0	0	0.006122	0	0
FLT4	2324	broad.mit.edu	37	5	180048740	180048740	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:180048740G>A	uc003mma.3	-	13	1901	c.1822C>T	c.(1822-1824)CTC>TTC	p.L608F	FLT4_uc003mlz.3_Missense_Mutation_p.L608F|FLT4_uc003mmb.1_Missense_Mutation_p.L141F|FLT4_uc011dgy.1_Missense_Mutation_p.L608F	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	608	Ig-like C2-type 6.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TTGCAGTCGAGCAGAAGCGGG	0.657	Colon(97;1075 1466 27033 27547 35871)		NA							Congenital_Hereditary_Lymphedema				11	26					0	0	0.008291	0	0
FLT4	2324	broad.mit.edu	37	5	180051011	180051011	+	Missense_Mutation	SNP	G	G	T	rs146167161	byFrequency	TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:180051011G>T	uc003mma.3	-	11	1551	c.1472C>A	c.(1471-1473)GCG>GAG	p.A491E	FLT4_uc003mlz.3_Missense_Mutation_p.A491E|FLT4_uc003mmb.1_Missense_Mutation_p.A24E|FLT4_uc011dgy.1_Missense_Mutation_p.A491E	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	491	Ig-like C2-type 5.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CGTGGTCACCGCCCTCCAGTC	0.637	Colon(97;1075 1466 27033 27547 35871)		NA							Congenital_Hereditary_Lymphedema				13	36					5.50884e-06	6.74373e-06	0.001368	1	0
EXOC2	55770	broad.mit.edu	37	6	572554	572554	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:572554C>T	uc003mtd.2	-	13	1543	c.1409G>A	c.(1408-1410)TGG>TAG	p.W470*	EXOC2_uc003mte.2_Nonsense_Mutation_p.W470*|EXOC2_uc011dho.1_Nonsense_Mutation_p.W65*	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	470					exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		GTAGGAGATCCAGAGTTTCCA	0.478			NA											16	53					0	0	0.00499	0	0
SERPINB9	5272	broad.mit.edu	37	6	2900746	2900746	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:2900746T>C	uc003mug.2	-	2	221	c.100A>G	c.(100-102)AGC>GGC	p.S34G	uc003mue.2_RNA|SERPINB9_uc003muh.2_Missense_Mutation_p.S34G	NM_004155	NP_004146	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B, member 9	34					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.108)				GAGGAGATGCTCACAGGAGAA	0.522			NA											64	118					0	0	0.00361	0	0
RBM24	221662	broad.mit.edu	37	6	17292055	17292055	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:17292055C>A	uc003nbz.3	+	4	420	c.416C>A	c.(415-417)CCG>CAG	p.P139Q	RBM24_uc003nby.3_3'UTR|RBM24_uc011dix.1_Missense_Mutation_p.P81Q|RBM24_uc003nca.2_Missense_Mutation_p.P94Q|RBM24_uc011diy.1_Silent_p.R53R|RBM24_uc011diz.1_Silent_p.R38R	NM_001143942	NP_001137414	Q9BX46	RBM24_HUMAN	RNA binding motif protein 24 isoform 1	139					cell differentiation|regulation of mRNA stability|regulation of myotube differentiation	cytoplasm|nucleus	mRNA 3'-UTR binding|nucleotide binding			ovary(1)|skin(1)	2	Breast(50;0.0615)|Ovarian(93;0.0733)	all_hematologic(90;0.062)	all cancers(50;0.131)|Epithelial(50;0.15)			CACGTCCAGCCGACAGCAGCT	0.463			NA											41	120					1.32136e-16	2.20226e-16	0.00874	1	0
CAP2	10486	broad.mit.edu	37	6	17421832	17421832	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:17421832A>G	uc003ncb.2	+	2	289	c.46A>G	c.(46-48)AGC>GGC	p.S16G	CAP2_uc010jpk.1_RNA|CAP2_uc011dja.1_Missense_Mutation_p.S16G|CAP2_uc011djb.1_Missense_Mutation_p.S16G|CAP2_uc011djc.1_Missense_Mutation_p.S16G|CAP2_uc011djd.1_Missense_Mutation_p.S16G	NM_006366	NP_006357	P40123	CAP2_HUMAN	adenylyl cyclase-associated protein 2	16					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			ovary(1)	1	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			ACGAGCTGTCAGCCGCCTGGA	0.557			NA											14	123					0	0	0.001855	0	0
HIST1H2AE	3012	broad.mit.edu	37	6	26217275	26217275	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:26217275C>T	uc003nha.1	+	1	128	c.73C>T	c.(73-75)CAG>TAG	p.Q25*	HIST1H2BG_uc003ngz.2_5'Flank	NM_021052	NP_066390	P04908	H2A1B_HUMAN	histone cluster 1, H2ae	25					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|skin(1)	2		all_hematologic(11;0.196)				GGCCGGTCTTCAGTTTCCAGT	0.577			NA											6	49					0	0	0.001168	0	0
HIST1H3F	8968	broad.mit.edu	37	6	26250535	26250535	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:26250535T>A	uc003nhg.1	-	1	301	c.299A>T	c.(298-300)TAC>TTC	p.Y100F	HIST1H2BH_uc003nhh.2_5'Flank	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	100				Y -> T (in Ref. 7; CAB02546).	blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0						CCCCACCAGGTAAGCCTCGCA	0.612			NA									OREG0017241	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	119					0	0	0.001855	0	0
HIST1H2BH	8345	broad.mit.edu	37	6	26252083	26252083	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:26252083G>C	uc003nhh.2	+	1	205	c.205G>C	c.(205-207)GAT>CAT	p.D69H	HIST1H3F_uc003nhg.1_5'Flank	NM_003524	NP_003515	Q93079	H2B1H_HUMAN	histone cluster 1, H2bh	69					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)	3						CTTTGTCAACGATATCTTCGA	0.567			NA											64	121					0	0	0.00361	0	0
PRSS16	10279	broad.mit.edu	37	6	27222785	27222785	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:27222785G>C	uc003nja.2	+	11	1363	c.1351G>C	c.(1351-1353)GTG>CTG	p.V451L	PRSS16_uc011dkt.1_RNA|PRSS16_uc003njb.2_Missense_Mutation_p.V194L|PRSS16_uc003njd.2_RNA	NM_005865	NP_005856	Q9NQE7	TSSP_HUMAN	protease, serine, 16 precursor	451					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			ovary(2)|central_nervous_system(2)|skin(1)	5						CCCCTGGCATGTGCTAAGTGT	0.547	NSCLC(178;1118 2105 17078 23587 44429)		NA											50	191					0	0	0.00361	0	0
ZKSCAN4	387032	broad.mit.edu	37	6	28217492	28217492	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:28217492G>C	uc003nks.1	-	2	788	c.544C>G	c.(544-546)CTG>GTG	p.L182V	ZKSCAN4_uc011dlb.1_Missense_Mutation_p.L27V	NM_019110	NP_061983	Q969J2	ZKSC4_HUMAN	zinc finger with KRAB and SCAN domains 4	182					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TGGGATCCCAGAGATTCATGC	0.433			NA											14	135					0	0	0.001855	0	0
NKAPL	222698	broad.mit.edu	37	6	28227250	28227250	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:28227250G>C	uc003nkt.2	+	1	153	c.101G>C	c.(100-102)TGT>TCT	p.C34S	ZKSCAN4_uc011dlb.1_5'Flank	NM_001007531	NP_001007532	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	34										upper_aerodigestive_tract(1)|ovary(1)	2						CAGAGCAGATGTTCCTCTTGG	0.637			NA											16	39					0	0	0.003163	0	0
ZNF323	64288	broad.mit.edu	37	6	28297162	28297162	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:28297162C>G	uc003nla.2	-	2	699	c.299G>C	c.(298-300)CGG>CCG	p.R100P	ZNF323_uc003nld.2_Missense_Mutation_p.R100P|ZNF323_uc010jra.2_Missense_Mutation_p.R100P|ZNF323_uc003nlb.2_Intron|ZNF323_uc010jrb.2_Intron|ZNF323_uc003nlc.2_Missense_Mutation_p.R100P	NM_001135216	NP_001128688	Q96LW9	ZN323_HUMAN	zinc finger protein 323	100	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						ATGGTGCTCCCGCACCCAGGC	0.562	Colon(115;1052 1587 16954 47314 53012)		NA											112	176					0	0	0.00361	0	0
NOTCH4	4855	broad.mit.edu	37	6	32163899	32163899	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:32163899C>T	uc003obb.2	-	30	5466	c.5327G>A	c.(5326-5328)CGG>CAG	p.R1776Q	GPSM3_uc003oaz.2_5'Flank|NOTCH4_uc011dpt.1_Silent_p.A152A|NOTCH4_uc003oba.2_Missense_Mutation_p.R436Q|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc011dpw.1_3'UTR	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1776	ANK 5.|Cytoplasmic (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						CGCTCCTTCCCGCGCCGCCAG	0.672			NA											4	8					0	0	0.009096	0	0
HLA-DPB1	3115	broad.mit.edu	37	6	33052926	33052926	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:33052926G>T	uc003ocu.1	+	3	623	c.564G>T	c.(562-564)CTG>CTT	p.L188L	HLA-DPB1_uc011dqo.1_RNA|HLA-DPB1_uc011dqp.1_Silent_p.L187L|HLA-DPB1_uc011dqq.1_Silent_p.L84L	NM_002121	NP_002112	P04440	DPB1_HUMAN	major histocompatibility complex, class II, DP	188	Beta-2.|Ig-like C1-type.|Extracellular (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to membrane|lysosomal membrane|MHC class II protein complex				ovary(1)	1						TGGTGATGCTGGAAATGACCC	0.562			NA											54	75					1.0442e-30	1.94446e-30	0.00361	1	0
DAXX	1616	broad.mit.edu	37	6	33287597	33287597	+	Silent	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:33287597T>C	uc003oec.2	-	6	1704	c.1500A>G	c.(1498-1500)CTA>CTG	p.L500L	ZBTB22_uc003oeb.2_5'Flank|ZBTB22_uc010juu.2_5'Flank|DAXX_uc011drd.1_Silent_p.L425L|DAXX_uc011dre.1_Silent_p.L512L|DAXX_uc003oed.2_Silent_p.L500L	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	500	Asp/Glu-rich (acidic).|Necessary for interaction with USP7.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						TGGAGATCTGTAGTGAGGACA	0.478			NA	Mis|F|N		Pancreatic neuroendocrine tumors								27	53					0	0	0.005443	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34826039	34826039	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:34826039C>T	uc003oju.3	+	14	2140	c.1906C>T	c.(1906-1908)CGG>TGG	p.R636W	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	636										ovary(3)	3						GAGTCTCTTCCGGGGTTTTGC	0.488			NA											57	92					0	0	0.00361	0	0
KIF6	221458	broad.mit.edu	37	6	39507930	39507930	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:39507930C>A	uc003oot.2	-	13	1589	c.1494G>T	c.(1492-1494)ATG>ATT	p.M498I	KIF6_uc010jwz.1_5'UTR|KIF6_uc010jxa.1_Missense_Mutation_p.M289I|KIF6_uc011dua.1_Missense_Mutation_p.M498I|KIF6_uc010jxb.1_Intron	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	498					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						CACGTCTATCCATGCCAGCCA	0.478			NA											13	241					2.31682e-05	2.7594e-05	0.003163	1	0
PTK7	5754	broad.mit.edu	37	6	43109784	43109784	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:43109784G>C	uc003oub.1	+	12	2082	c.1884G>C	c.(1882-1884)AAG>AAC	p.K628N	PTK7_uc003ouc.1_Intron|PTK7_uc003oud.1_Missense_Mutation_p.K588N|PTK7_uc003oue.1_Missense_Mutation_p.K498N|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Missense_Mutation_p.K636N|PTK7_uc010jyj.1_Intron	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	628	Ig-like C2-type 7.|Extracellular (Potential).				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GGAAAGGCAAGGACCGCATCC	0.662			NA											13	23					0	0	0.001855	0	0
C6orf223	221416	broad.mit.edu	37	6	43970830	43970830	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:43970830G>T	uc003own.2	+	4	714	c.696G>T	c.(694-696)GCG>GCT	p.A232A	uc003owm.1_Intron|C6orf223_uc003owo.2_Silent_p.A212A	NM_153246	NP_694978	Q8N319	CF223_HUMAN	hypothetical protein LOC221416	232											0	all_cancers(18;2.28e-07)|all_epithelial(2;1.62e-08)|Lung NSC(15;0.000172)|all_lung(25;0.000533)|Hepatocellular(11;0.00309)|Ovarian(13;0.0437)		all cancers(41;0.00141)|Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.217)			CATCCGCGGCGCTCCGCGGCG	0.662			NA											14	45					1.37285e-15	2.24675e-15	0.004007	1	0
GPR115	221393	broad.mit.edu	37	6	47682493	47682493	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:47682493C>T	uc003oza.1	+	6	1770	c.1512C>T	c.(1510-1512)GTC>GTT	p.V504V	GPR115_uc003oyz.1_Silent_p.V561V|GPR115_uc003ozb.1_Silent_p.V502V	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	504	Helical; Name=3; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						GAATATTGGTCATTTTCCGTA	0.423	GBM(22;431 510 9010 26644 32828)		NA											19	203					0	0	0.008871	0	0
DEFB110	245913	broad.mit.edu	37	6	49986799	49986799	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:49986799C>A	uc003pac.2	-	2	141	c.95G>T	c.(94-96)AGG>ATG	p.R32M	DEFB110_uc011dwr.1_Intron	NM_001037497	NP_001032586	Q30KQ9	DB110_HUMAN	beta-defensin 110 isoform a	32					defense response to bacterium	extracellular region				ovary(1)	1	Lung NSC(77;0.042)					GCACTCTCTCCTCAAGTCCAA	0.373			NA											20	124					2.70639e-06	3.36932e-06	0.002299	1	0
TFAP2B	7021	broad.mit.edu	37	6	50803856	50803856	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:50803856G>C	uc003pag.2	+	4	850	c.684G>C	c.(682-684)GAG>GAC	p.E228D		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	228					nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					ACACCGGCGAGGTGTTTTGCT	0.493	Pancreas(116;1373 2332 5475 10752)		NA											9	131					0	0	0.006214	0	0
GCLC	2729	broad.mit.edu	37	6	53379289	53379289	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:53379289T>A	uc003pbw.1	-	5	955	c.567A>T	c.(565-567)TTA>TTT	p.L189F	GCLC_uc003pbx.2_Missense_Mutation_p.L189F	NM_001498	NP_001489	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	189					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			ovary(1)|central_nervous_system(1)	2	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	TATTTCTTGTTAAGGTACTAA	0.383			NA											4	50					0	0	0.009096	0	0
HCRTR2	3062	broad.mit.edu	37	6	55145222	55145222	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:55145222T>A	uc003pcl.2	+	6	1400	c.1085T>A	c.(1084-1086)ATT>AAT	p.I362N	HCRTR2_uc010jzv.2_RNA	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	362	Helical; Name=7; (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GCGAATCCAATTATTTATAAT	0.318			NA											34	68					0	0	0.002445	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55364081	55364081	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:55364081G>T	uc003pcn.2	-	7	808	c.649C>A	c.(649-651)CTG>ATG	p.L217M	HMGCLL1_uc003pco.2_Missense_Mutation_p.L187M|HMGCLL1_uc010jzx.2_Missense_Mutation_p.L88M|HMGCLL1_uc011dxc.1_Missense_Mutation_p.L155M|HMGCLL1_uc011dxd.1_Intron|HMGCLL1_uc011dxe.1_Intron	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	217							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			GGACAGCCCAGAGCACAAGAC	0.303	Ovarian(35;840 893 7837 15538 42887)		NA											34	102					2.87052e-16	4.74823e-16	0.005524	1	0
KHDRBS2	202559	broad.mit.edu	37	6	62604730	62604730	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:62604730C>A	uc003peg.2	-	6	867	c.620G>T	c.(619-621)GGG>GTG	p.G207V		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	207					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		AATGGCACCCCCACGGCCCCT	0.532			NA											13	33					2.23348e-06	2.78733e-06	0.004007	1	0
EYS	346007	broad.mit.edu	37	6	66115103	66115103	+	Silent	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:66115103T>A	uc011dxu.1	-	6	1558	c.1020A>T	c.(1018-1020)CCA>CCT	p.P340P	EYS_uc003peq.2_Silent_p.P340P|EYS_uc003per.1_Silent_p.P340P	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	340	EGF-like 4.				response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						CATTCTGACATGGTACTAATG	0.333			NA											35	93					0	0	0.002836	0	0
EYS	346007	broad.mit.edu	37	6	66115229	66115229	+	Silent	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:66115229A>G	uc011dxu.1	-	6	1432	c.894T>C	c.(892-894)TGT>TGC	p.C298C	EYS_uc003peq.2_Silent_p.C298C|EYS_uc003per.1_Silent_p.C298C	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	298					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						GCAGAGAAACACAAGGTTTTG	0.368			NA											25	195					0	0	0.004656	0	0
COL9A1	1297	broad.mit.edu	37	6	70944628	70944628	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:70944628C>A	uc003pfg.3	-	34	2287	c.2128G>T	c.(2128-2130)GAA>TAA	p.E710*	COL9A1_uc003pfe.3_Nonsense_Mutation_p.E259*|COL9A1_uc003pff.3_Nonsense_Mutation_p.E467*	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	710	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						AAGCCAGGTTCCCCAGGATTA	0.527			NA											17	26					0.00074312	0.000831086	0.006122	1	0
KCNQ5	56479	broad.mit.edu	37	6	73904298	73904298	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:73904298A>G	uc003pgk.2	+	14	2307	c.1960A>G	c.(1960-1962)ACA>GCA	p.T654A	KCNQ5_uc011dyh.1_Missense_Mutation_p.T673A|KCNQ5_uc011dyi.1_Missense_Mutation_p.T664A|KCNQ5_uc010kat.2_Missense_Mutation_p.T645A|KCNQ5_uc011dyj.1_Missense_Mutation_p.T544A|KCNQ5_uc011dyk.1_Missense_Mutation_p.T404A	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	654					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		ATGTGAACAGACATCTGACTA	0.493	GBM(142;1375 1859 14391 23261 44706)		NA											8	113					0	0	0.004482	0	0
COL12A1	1303	broad.mit.edu	37	6	75827165	75827165	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:75827165G>T	uc003phs.2	-	47	7618	c.7452C>A	c.(7450-7452)GAC>GAA	p.D2484E	COL12A1_uc003pht.2_Missense_Mutation_p.D1320E	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2484	Nonhelical region (NC3).|VWFA 4.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						ATTCAAAGTCGTCCACAATGA	0.423			NA											7	86					0.00198382	0.00218689	0.001984	1	0
COL12A1	1303	broad.mit.edu	37	6	75875431	75875431	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:75875431C>A	uc003phs.2	-	14	2941	c.2775G>T	c.(2773-2775)TGG>TGT	p.W925C	COL12A1_uc003pht.2_Intron	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	925	Fibronectin type-III 6.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						GAGCAGATGTCCAATAAGCCC	0.388			NA											12	93					7.03913e-09	9.75721e-09	0.001368	1	0
IMPG1	3617	broad.mit.edu	37	6	76715026	76715026	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:76715026C>A	uc003pik.1	-	10	1243	c.1113G>T	c.(1111-1113)GTG>GTT	p.V371V		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	371					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				GAATTGTCCCCACATCCAAAG	0.418	Pancreas(37;839 1141 2599 26037)		NA											5	95					0.000602214	0.000674971	0.000602	1	0
BCKDHB	594	broad.mit.edu	37	6	80878646	80878646	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:80878646G>T	uc003pjd.2	+	5	599	c.532G>T	c.(532-534)GGA>TGA	p.G178*	BCKDHB_uc003pje.2_Nonsense_Mutation_p.G178*	NM_000056	NP_000047	P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1 beta	178					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding				0		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		TTTTAACTGTGGAAGCCTCAC	0.498			NA											52	97					3.10996e-30	5.77029e-30	0.00361	1	0
PRSS35	167681	broad.mit.edu	37	6	84233730	84233730	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:84233730G>C	uc003pjz.2	+	2	733	c.570G>C	c.(568-570)AAG>AAC	p.K190N	PRSS35_uc010kbm.2_Missense_Mutation_p.K190N	NM_153362	NP_699193	Q8N3Z0	PRS35_HUMAN	protease, serine, 35 precursor	190	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		GGTTGTTGAAGATGAGGAATA	0.473			NA											39	66					0	0	0.006999	0	0
TBX18	9096	broad.mit.edu	37	6	85446572	85446572	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:85446572C>A	uc003pkl.1	-	8	1655	c.1655G>T	c.(1654-1656)GGA>GTA	p.G552V	TBX18_uc010kbq.1_Intron	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	552					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		CAAGAAACTTCCTTGGGAAGA	0.512			NA											16	121					1.99824e-07	2.59686e-07	0.00499	1	0
HTR1E	3354	broad.mit.edu	37	6	87725964	87725964	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:87725964G>T	uc003pli.2	+	2	1615	c.912G>T	c.(910-912)TGG>TGT	p.W304C		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	304	Helical; Name=6; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	TTTTATCCTGGCTGCCATTTT	0.512			NA											19	204					8.34094e-07	1.05808e-06	0.008871	1	0
SPACA1	81833	broad.mit.edu	37	6	88773879	88773879	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:88773879A>G	uc003pmn.2	+	6	790	c.673A>G	c.(673-675)ATA>GTA	p.I225V		NM_030960	NP_112222	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1 precursor	225	Helical; (Potential).					integral to membrane					0		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		TGTGCTGACCATAGGAGTCAT	0.368			NA											6	99					0	0	0.001168	0	0
EPHA7	2045	broad.mit.edu	37	6	93956568	93956568	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:93956568G>C	uc003poe.2	-	15	2909	c.2668C>G	c.(2668-2670)CTA>GTA	p.L890V	EPHA7_uc003pof.2_Missense_Mutation_p.L885V|EPHA7_uc011eac.1_Missense_Mutation_p.L886V	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	890	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		ATTTTGTCTAGAATTCCAACT	0.438			NA											21	103					0	0	0.001882	0	0
EPHA7	2045	broad.mit.edu	37	6	93967841	93967841	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:93967841G>T	uc003poe.2	-	11	2327	c.2086C>A	c.(2086-2088)CAT>AAT	p.H696N	EPHA7_uc003pof.2_Missense_Mutation_p.H691N|EPHA7_uc011eac.1_Missense_Mutation_p.H692N	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	696	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CCTTCCAAATGGACAACATTC	0.353			NA											16	84					3.41278e-10	4.95352e-10	0.00499	1	0
GPR63	81491	broad.mit.edu	37	6	97247514	97247514	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:97247514G>T	uc010kcl.2	-	3	572	c.94C>A	c.(94-96)CCT>ACT	p.P32T	GPR63_uc003pou.2_Missense_Mutation_p.P32T	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	32	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		AATGGTGGAGGGAGTGTAATA	0.458			NA											10	90					9.70103e-10	1.38844e-09	0.008291	1	0
KLHL32	114792	broad.mit.edu	37	6	97562151	97562151	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:97562151C>G	uc010kcm.1	+	7	1592	c.1120C>G	c.(1120-1122)CGC>GGC	p.R374G	KLHL32_uc003poy.2_Missense_Mutation_p.R374G|KLHL32_uc011ead.1_Missense_Mutation_p.R338G|KLHL32_uc003poz.2_Intron|KLHL32_uc011eae.1_Missense_Mutation_p.R305G|KLHL32_uc003ppa.2_Intron	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	374	Kelch 2.									ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		CTATGACCCCCGCAGTAATTC	0.567			NA											15	28					0	0	0.00245	0	0
MCHR2	84539	broad.mit.edu	37	6	100395638	100395638	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:100395638C>T	uc003pqh.1	-	3	707	c.392G>A	c.(391-393)AGG>AAG	p.R131K	MCHR2_uc003pqi.1_Missense_Mutation_p.R131K	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	131	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		TTTCACTTACCTGTCCACACT	0.443			NA											34	186					0	0	0.003271	0	0
MCHR2	84539	broad.mit.edu	37	6	100403903	100403903	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:100403903T>C	uc003pqh.1	-	2	436	c.121A>G	c.(121-123)ATT>GTT	p.I41V	MCHR2_uc003pqi.1_Missense_Mutation_p.I41V	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	41	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		ATAATCCCAATCATGGAAGGG	0.393			NA											22	57					0	0	0.002299	0	0
SOBP	55084	broad.mit.edu	37	6	107824904	107824904	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:107824904G>T	uc003prx.2	+	2	644	c.140G>T	c.(139-141)GGC>GTC	p.G47V	SOBP_uc003prw.1_Missense_Mutation_p.G47V	NM_018013	NP_060483	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog	47							metal ion binding			ovary(1)	1		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		GGCTGGTATGGCTATGATAAG	0.388			NA											9	76					0.000274275	0.000311722	0.004482	1	0
ARMC2	84071	broad.mit.edu	37	6	109190162	109190162	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:109190162G>T	uc003pss.3	+	4	601	c.427G>T	c.(427-429)GCC>TCC	p.A143S	ARMC2_uc011eao.1_5'UTR	NM_032131	NP_115507	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	143							binding				0		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)		CTCCCAGCGGGCCCTTCTGCC	0.542			NA											23	60					2.44723e-14	3.90543e-14	0.004656	1	0
GPR6	2830	broad.mit.edu	37	6	110300858	110300858	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:110300858C>A	uc011eaw.1	+	2	723	c.543C>A	c.(541-543)ACC>ACA	p.T181T	GPR6_uc011eav.1_Silent_p.T196T|GPR6_uc003ptu.2_Silent_p.T181T	NM_005284	NP_005275	P46095	GPR6_HUMAN	G protein-coupled receptor 6	181	Cytoplasmic (Potential).					integral to plasma membrane					0		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		CGCGCCGGACCCTGTTGGGCG	0.672			NA											7	50					1.06961e-07	1.40907e-07	0.00308	1	0
LAMA4	3910	broad.mit.edu	37	6	112496655	112496655	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:112496655C>A	uc003pvu.2	-	11	1526	c.1217G>T	c.(1216-1218)GGG>GTG	p.G406V	LAMA4_uc003pvv.2_Missense_Mutation_p.G399V|LAMA4_uc003pvt.2_Missense_Mutation_p.G399V	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	406	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		ATGCTCTTCCCCATAATAGAG	0.468			NA											48	117					2.43139e-17	4.08326e-17	0.00361	1	0
ROS1	6098	broad.mit.edu	37	6	117706999	117706999	+	Silent	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:117706999G>C	uc003pxp.1	-	15	2350	c.2151C>G	c.(2149-2151)CTC>CTG	p.L717L	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	717	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CACTGTAGTAGAGGCTGTTGT	0.403			NA	T	GOPC|ROS1	glioblastoma|NSCLC								11	73					0	0	0.008291	0	0
DCBLD1	285761	broad.mit.edu	37	6	117841007	117841007	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:117841007C>T	uc003pxs.2	+	3	479	c.354C>T	c.(352-354)CCC>CCT	p.P118P	GOPC_uc003pxq.1_Intron|DCBLD1_uc003pxr.1_Silent_p.P118P	NM_173674	NP_775945	Q8N8Z6	DCBD1_HUMAN	discoidin, CUB and LCCL domain containing 1	118	CUB.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(1)	1		all_cancers(87;0.171)		GBM - Glioblastoma multiforme(226;0.0447)|OV - Ovarian serous cystadenocarcinoma(136;0.0921)|all cancers(137;0.125)		TGACTGTTCCCAAAGAACTCT	0.438			NA											8	73					0	0	0.004482	0	0
NKAIN2	154215	broad.mit.edu	37	6	125139561	125139561	+	Silent	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:125139561T>C	uc003pzo.2	+	6	841	c.564T>C	c.(562-564)TAT>TAC	p.Y188Y	NKAIN2_uc003pzp.2_Silent_p.Y187Y|NKAIN2_uc010keq.2_Silent_p.Y121Y|NKAIN2_uc010ker.2_Silent_p.Y98Y	NM_001040214	NP_001035304	Q5VXU1	NKAI2_HUMAN	T-cell lymphoma breakpoint-associated target 1	188						integral to membrane|plasma membrane					0				GBM - Glioblastoma multiforme(226;0.104)		TTGACTCTTATGGCTATCAAG	0.373			NA											5	70					0	0	0.001168	0	0
THEMIS	387357	broad.mit.edu	37	6	128040881	128040881	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:128040881C>A	uc003qbi.2	-	6	2165	c.1846G>T	c.(1846-1848)GTG>TTG	p.V616L	THEMIS_uc010kfa.2_Missense_Mutation_p.V519L|THEMIS_uc011ebt.1_Missense_Mutation_p.V655L|THEMIS_uc010kfb.2_Missense_Mutation_p.V581L	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	616					negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						TCTTCATCCACCAAATCATTC	0.443			NA											9	80					3.09899e-07	3.99367e-07	0.004482	1	0
TMEM200A	114801	broad.mit.edu	37	6	130761821	130761821	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:130761821C>A	uc003qca.2	+	3	1125	c.254C>A	c.(253-255)CCC>CAC	p.P85H	TMEM200A_uc010kfh.2_Missense_Mutation_p.P85H|TMEM200A_uc010kfi.2_Missense_Mutation_p.P85H|TMEM200A_uc003qcb.2_Missense_Mutation_p.P85H	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	85	Extracellular (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		GGATATTGGCCCCAAAAAGAA	0.423			NA											5	95					3.59834e-05	4.24306e-05	0.001168	1	0
TXLNB	167838	broad.mit.edu	37	6	139564124	139564124	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:139564124C>A	uc011eds.1	-	10	1759	c.1594G>T	c.(1594-1596)GAG>TAG	p.E532*		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	532						cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		TCAGCACTCTCCTGAGAACTG	0.557			NA											14	143					0.000219431	0.000251245	0.00245	1	0
UTRN	7402	broad.mit.edu	37	6	145069549	145069549	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:145069549C>T	uc003qkt.2	+	54	8199	c.8107C>T	c.(8107-8109)CTG>TTG	p.L2703L		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2703	Spectrin 20.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TATGGATGACCTGGACGCTGA	0.483			NA											4	37					0	0	0.009096	0	0
RAET1E	135250	broad.mit.edu	37	6	150210584	150210584	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:150210584G>C	uc003qnl.1	-	3	582	c.522C>G	c.(520-522)GAC>GAG	p.D174E	uc003qni.1_Intron|RAET1E_uc003qnj.2_Missense_Mutation_p.D174E|RAET1E_uc003qnk.1_Missense_Mutation_p.D138E|RAET1E_uc010kih.1_RNA	NM_139165	NP_631904	Q8TD07	N2DL4_HUMAN	retinoic acid early transcript 1E precursor	174	Extracellular (Potential).|MHC class I alpha-2 like.				antigen processing and presentation|immune response|regulation of immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		CCAGCCCTCTGTCTTTCTTCC	0.483			NA											9	117					0	0	0.006214	0	0
ARID1B	57492	broad.mit.edu	37	6	157505488	157505488	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:157505488G>A	uc003qqn.2	+	13	3567	c.3415G>A	c.(3415-3417)GAA>AAA	p.E1139K	ARID1B_uc003qqo.2_Missense_Mutation_p.E1099K|ARID1B_uc003qqp.2_Missense_Mutation_p.E1086K|ARID1B_uc010kjl.2_Missense_Mutation_p.E284K	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1144	ARID.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GTGCAAGATCGAACGTGGGGA	0.577			NA											5	53					0	0	0.001168	0	0
IGF2R	3482	broad.mit.edu	37	6	160523695	160523695	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:160523695G>C	uc003qta.2	+	46	7135	c.6987G>C	c.(6985-6987)AAG>AAC	p.K2329N		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	2329	Cytoplasmic (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		TCTACAAGAAGGAGAGGAGGT	0.597			NA											7	6					0	0	0.001984	0	0
SLC22A3	6581	broad.mit.edu	37	6	160858107	160858107	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:160858107C>T	uc003qti.2	+	7	1179	c.1152C>T	c.(1150-1152)TTC>TTT	p.F384F	SLC22A3_uc011efx.1_RNA	NM_021977	NP_068812	O75751	S22A3_HUMAN	solute carrier family 22 member 3	384	Helical; (Potential).					integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		TAGACTTTTTCATCTCGGGCG	0.507			NA											15	177					0	0	0.003163	0	0
PARK2	5071	broad.mit.edu	37	6	161969909	161969909	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:161969909C>G	uc003qtx.3	-	9	1194	c.1060G>C	c.(1060-1062)GGG>CGG	p.G354R	PARK2_uc003qtv.3_Intron|PARK2_uc010kkd.2_Missense_Mutation_p.G163R|PARK2_uc003qtw.3_Missense_Mutation_p.G163R|PARK2_uc003qty.3_Missense_Mutation_p.G326R|PARK2_uc003qtz.3_Missense_Mutation_p.G205R|PARK2_uc010kke.1_Missense_Mutation_p.G373R|PARK2_uc011egf.1_Missense_Mutation_p.G28R	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	354	IBR-type.				aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		CCATTGCCCCCTTCGCAGGTG	0.612			NA											30	108					0	0	0.007291	0	0
PARK2	5071	broad.mit.edu	37	6	162394430	162394430	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:162394430C>A	uc003qtx.3	-	6	772	c.638G>T	c.(637-639)GGA>GTA	p.G213V	PARK2_uc003qtv.3_RNA|PARK2_uc010kkd.2_Missense_Mutation_p.G22V|PARK2_uc003qtw.3_Missense_Mutation_p.G22V|PARK2_uc003qty.3_Missense_Mutation_p.G185V|PARK2_uc003qtz.3_Missense_Mutation_p.G64V|PARK2_uc010kke.1_Missense_Mutation_p.G213V	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	213	SYT11 binding 1.				aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		GGGGTGTGCTCCACATTTAAA	0.413			NA											11	39					3.03607e-14	4.82016e-14	0.001368	1	0
THBS2	7058	broad.mit.edu	37	6	169629714	169629714	+	Missense_Mutation	SNP	C	C	T	rs61736310		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:169629714C>T	uc003qwt.2	-	15	2460	c.2212G>A	c.(2212-2214)GAT>AAT	p.D738N		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	738	TSP type-3 2.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		TCACAGGCATCGCCAATCCCG	0.527	Esophageal Squamous(91;219 1934 18562 44706)		NA											15	151					0	0	0.006122	0	0
WDR27	253769	broad.mit.edu	37	6	170033053	170033053	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:170033053C>A	uc003qwx.2	-	21	2733	c.2213G>T	c.(2212-2214)TGC>TTC	p.C738F	WDR27_uc003qwv.1_RNA|WDR27_uc010kkw.1_Missense_Mutation_p.C738F|WDR27_uc003qwy.2_Missense_Mutation_p.C611F			A2RRH5	WDR27_HUMAN	RecName: Full=WD repeat-containing protein 27;	708	WD 8.									pancreas(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		TTTATTTTGGCAGATTTGATG	0.448			NA											7	26					2.0095e-06	2.51391e-06	0.001984	1	0
DLL1	28514	broad.mit.edu	37	6	170592564	170592564	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:170592564G>A	uc003qxm.2	-	9	2273	c.1803C>T	c.(1801-1803)GAC>GAT	p.D601D		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	601	Cytoplasmic (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		TGACTGAGATGTCCTTCTCAC	0.637			NA											11	110					0	0	0.00245	0	0
FAM120B	84498	broad.mit.edu	37	6	170627006	170627006	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr6:170627006G>T	uc003qxp.2	+	2	636	c.528G>T	c.(526-528)CTG>CTT	p.L176L	FAM120B_uc003qxo.1_Silent_p.L176L|FAM120B_uc011ehd.1_Intron	NM_032448	NP_115824	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	176					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		TTGGGATTCTGGGGGAAGACA	0.478			NA											35	90					1.36615e-20	2.35859e-20	0.002836	1	0
PDGFA	5154	broad.mit.edu	37	7	550517	550517	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:550517G>A	uc003sir.2	-	4	1225	c.382C>T	c.(382-384)CGC>TGC	p.R128C	PDGFA_uc003sis.2_Missense_Mutation_p.R128C|PDGFA_uc003sit.1_Missense_Mutation_p.R142C	NM_002607	NP_002598	P04085	PDGFA_HUMAN	platelet-derived growth factor alpha isoform 1	128					actin cytoskeleton organization|angiogenesis|cell projection assembly|embryo development|hair follicle development|lung alveolus development|negative chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|organ morphogenesis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of DNA replication|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of MAP kinase activity|positive regulation of mesenchymal cell proliferation|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein kinase B signaling cascade|regulation of actin cytoskeleton organization|regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling|regulation of peptidyl-tyrosine phosphorylation|regulation of smooth muscle cell migration|skin development	cell surface|endoplasmic reticulum lumen|extracellular space|Golgi membrane|microvillus|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity				0		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|Epithelial(4;1.1e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.7e-17)|all cancers(6;4.89e-15)		CCGGTGCAGCGTTTCACCTCC	0.552			NA											7	14					0	0	0.00308	0	0
INTS1	26173	broad.mit.edu	37	7	1538688	1538688	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:1538688G>A	uc003skn.2	-	8	1161	c.1060C>T	c.(1060-1062)CTC>TTC	p.L354F	INTS1_uc003skq.2_Missense_Mutation_p.L354F	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	354					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		GTGGAGGTGAGGAGCCGCAGG	0.577			NA											4	7					0	0	0.009096	0	0
SDK1	221935	broad.mit.edu	37	7	4007027	4007027	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:4007027G>T	uc003smx.2	+	10	1646	c.1507G>T	c.(1507-1509)GTG>TTG	p.V503L		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	503	Ig-like C2-type 5.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AAGGTGTGAGGTGTCCGGGGC	0.542			NA											14	82					3.27435e-08	4.40009e-08	0.00245	1	0
FOXK1	221937	broad.mit.edu	37	7	4796696	4796696	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:4796696G>T	uc003snc.1	+	5	1132	c.1122G>T	c.(1120-1122)GGG>GGT	p.G374G	FOXK1_uc003sna.1_Silent_p.G211G	NM_001037165	NP_001032242	P85037	FOXK1_HUMAN	forkhead box K1	374	Fork-head.				cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			upper_aerodigestive_tract(1)|skin(1)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		AGGAGCCTGGGAAGGGGTCCT	0.552			NA											44	86					2.37825e-27	4.32409e-27	0.002522	1	0
RADIL	55698	broad.mit.edu	37	7	4874576	4874576	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:4874576G>T	uc003snj.1	-	4	1251	c.1078C>A	c.(1078-1080)CAG>AAG	p.Q360K	RADIL_uc003sng.1_RNA|RADIL_uc003sni.1_5'Flank|RADIL_uc011jwc.1_Missense_Mutation_p.Q120K|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	360	FHA.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		GGCTGGGCCTGCGCGGGGTCC	0.746			NA											5	12					5.9392e-07	7.59035e-07	0.001168	1	0
TNRC18	84629	broad.mit.edu	37	7	5410699	5410699	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:5410699C>A	uc003soi.3	-	11	3875	c.3526G>T	c.(3526-3528)GAG>TAG	p.E1176*		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1176	Pro-rich.						DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		AGCGGCGACTCCAGAGGCGGC	0.716			NA											4	40					0.00024832	0.000283269	0.009096	1	0
TNRC18	84629	broad.mit.edu	37	7	5427458	5427458	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:5427458C>A	uc003soi.3	-	5	2346	c.1997G>T	c.(1996-1998)CGC>CTC	p.R666L	TNRC18_uc010ksx.1_Missense_Mutation_p.R592L	NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	666							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		AGAGCCCTCGCGCCCGAAAGC	0.731			NA											3	35					0.004672	0.00508113	0.004672	1	0
RNF216	54476	broad.mit.edu	37	7	5680851	5680851	+	Missense_Mutation	SNP	T	T	A	rs141635295		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:5680851T>A	uc003soy.1	-	15	2335	c.2145A>T	c.(2143-2145)CAA>CAT	p.Q715H	RNF216_uc010ksz.1_Missense_Mutation_p.Q337H|RNF216_uc010kta.1_Missense_Mutation_p.Q337H|RNF216_uc011jwj.1_Missense_Mutation_p.Q337H|RNF216_uc003sox.1_Missense_Mutation_p.Q772H	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	715					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		AGCGGGGATGTTGGCAGAAAT	0.507			NA											38	67					0	0	0.00623	0	0
ICA1	3382	broad.mit.edu	37	7	8183563	8183563	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:8183563C>T	uc003srm.2	-	9	911	c.844G>A	c.(844-846)GAG>AAG	p.E282K	ICA1_uc010ktr.2_Missense_Mutation_p.E282K|ICA1_uc003srl.2_Missense_Mutation_p.E270K|ICA1_uc003srn.3_Missense_Mutation_p.E208K|ICA1_uc003srp.3_Missense_Mutation_p.E281K|ICA1_uc010kts.2_Intron|ICA1_uc003srq.2_Missense_Mutation_p.E282K|ICA1_uc003srr.2_Missense_Mutation_p.E281K|ICA1_uc003sro.3_Missense_Mutation_p.E282K	NM_022307	NP_071682	Q05084	ICA69_HUMAN	islet cell autoantigen 1	282					neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				central_nervous_system(1)	1		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		TTCTTCTTCTCTTCTTTCTCA	0.363			NA											18	40					0	0	0.010504	0	0
HDAC9	9734	broad.mit.edu	37	7	18832988	18832988	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:18832988G>A	uc003suh.2	+	16	2267	c.2226G>A	c.(2224-2226)TGG>TGA	p.W742*	HDAC9_uc003sue.2_Nonsense_Mutation_p.W742*|HDAC9_uc011jyd.1_Nonsense_Mutation_p.W742*|HDAC9_uc003sui.2_Nonsense_Mutation_p.W745*|HDAC9_uc003suj.2_Nonsense_Mutation_p.W701*|HDAC9_uc003suk.2_5'UTR|HDAC9_uc003sua.1_Nonsense_Mutation_p.W720*	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	742	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	ACACCATTTGGAATGAGCTAC	0.428			NA											3	9					0	0	0.004672	0	0
ABCB5	340273	broad.mit.edu	37	7	20691247	20691247	+	Splice_Site	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:20691247G>T	uc003suw.3	+	4	747	c.201_splice	c.e4+1	p.N67_splice	ABCB5_uc010kuh.2_Splice_Site_p.N512_splice|ABCB5_uc003suv.3_Splice_Site_p.N67_splice|ABCB5_uc011jyi.1_Splice_Site_p.N67_splice	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5						regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						GTTTCCTAATGTGAGTACACT	0.428			NA											26	54					1.66031e-10	2.42587e-10	0.003954	1	0
ABCB5	340273	broad.mit.edu	37	7	20721145	20721145	+	Silent	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:20721145T>C	uc003suw.3	+	6	936	c.390T>C	c.(388-390)ACT>ACC	p.T130T	ABCB5_uc010kuh.2_Silent_p.T575T	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	130	ABC transporter 1.|Extracellular (Potential).				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						AAGGTCGGACTACAATCGTGG	0.388			NA											6	64					0	0	0.001168	0	0
DNAH11	8701	broad.mit.edu	37	7	21640486	21640486	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:21640486G>T	uc003svc.2	+	16	3224	c.3193G>T	c.(3193-3195)GAT>TAT	p.D1065Y		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1065	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CGATGAAATGGATGCTCATGC	0.438			NA							Kartagener_syndrome				62	187					1.1362e-29	2.09801e-29	0.00361	1	0
CBX3	11335	broad.mit.edu	37	7	26251814	26251814	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:26251814G>T	uc003sxt.2	+	6	649	c.538G>T	c.(538-540)GAT>TAT	p.D180Y	CBX3_uc003sxu.2_Missense_Mutation_p.D180Y|CBX3_uc003sxv.2_3'UTR	NM_007276	NP_009207	Q13185	CBX3_HUMAN	chromobox homolog 3	180					chromatin remodeling|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed chromosome, centromeric region|nuclear centromeric heterochromatin|nuclear euchromatin|nuclear inner membrane|spindle	enzyme binding|protein domain specific binding			ovary(1)	1						TTGTCCAGAAGATGAAGCTCA	0.313			NA											6	37					0.00198382	0.00218689	0.001984	1	0
HOXA10	3206	broad.mit.edu	37	7	27213050	27213050	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:27213050C>A	uc011jzm.1	-	1	906	c.876G>T	c.(874-876)GCG>GCT	p.A292A	HOXA10_uc003syw.3_Intron	NM_018951	NP_061824	P31260	HXA10_HUMAN	homeobox A10 isoform a	292				A -> G (in Ref. 1; CAB86198).	spermatogenesis		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						ACGACGCGTGCGCCTCCTCGT	0.741			NA											4	16					0.000602214	0.000674971	0.000602	1	0
NOD1	10392	broad.mit.edu	37	7	30490920	30490920	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:30490920G>T	uc003tav.2	-	6	2636	c.2113C>A	c.(2113-2115)CGG>AGG	p.R705R		NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	705	LRR 2.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						AGGGCCAGCCGCTTGGGGAAG	0.627			NA											28	111					3.73148e-12	5.67273e-12	0.007291	1	0
PDE1C	5137	broad.mit.edu	37	7	31877505	31877505	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:31877505G>A	uc003tcm.1	-	10	1530	c.1061C>T	c.(1060-1062)ACT>ATT	p.T354I	PDE1C_uc003tcn.1_Missense_Mutation_p.T354I|PDE1C_uc003tco.1_Missense_Mutation_p.T414I|PDE1C_uc003tcr.2_Missense_Mutation_p.T354I|PDE1C_uc003tcs.2_Missense_Mutation_p.T354I	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	354	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			CTGCAGAGCAGTCTTCATTGC	0.433			NA											68	287					0	0	0.00361	0	0
FKBP9	11328	broad.mit.edu	37	7	33014286	33014286	+	Silent	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:33014286G>C	uc003tdh.2	+	2	460	c.279G>C	c.(277-279)GGG>GGC	p.G93G	AVL9_uc011kai.1_Intron|FKBP9_uc011kak.1_Intron|FKBP9_uc011kal.1_Silent_p.G146G|FKBP9_uc003tdg.2_Silent_p.G93G|FKBP9_uc010kwm.2_5'UTR	NM_007270	NP_009201	O95302	FKBP9_HUMAN	FK506 binding protein 9 precursor	93	PPIase FKBP-type 1.				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|ovary(1)	14			GBM - Glioblastoma multiforme(11;0.0156)			TGATCACAGGGATGGACCAGG	0.453			NA											86	219					0	0	0.00361	0	0
BMPER	168667	broad.mit.edu	37	7	34014337	34014337	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:34014337T>C	uc011kap.1	+	6	631	c.517T>C	c.(517-519)TAT>CAT	p.Y173H		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	173	VWFC 3.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						GGGTGTGCAGTATCAAGAAGG	0.483			NA											18	115					0	0	0.006122	0	0
NPSR1	387129	broad.mit.edu	37	7	34889208	34889208	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:34889208T>A	uc003teg.1	+	9	1185	c.1057T>A	c.(1057-1059)TTC>ATC	p.F353I	AAA1_uc010kwq.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Missense_Mutation_p.V386D|NPSR1_uc010kwt.1_Missense_Mutation_p.F200I|NPSR1_uc010kwu.1_Missense_Mutation_p.F143I|NPSR1_uc010kwv.1_Missense_Mutation_p.F287I|NPSR1_uc003tei.1_Intron|NPSR1_uc010kww.1_Intron|NPSR1_uc011kar.1_Intron	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	353	Cytoplasmic (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	CAGAATGACGTTCCGGGAGAG	0.468			NA											67	116					0	0	0.00361	0	0
ANLN	54443	broad.mit.edu	37	7	36446030	36446030	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:36446030G>C	uc003tff.2	+	4	932	c.728G>C	c.(727-729)GGA>GCA	p.G243A	ANLN_uc011kaz.1_Missense_Mutation_p.G155A|ANLN_uc003tfg.2_Missense_Mutation_p.G243A|ANLN_uc010kxe.2_Missense_Mutation_p.G243A	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	243	Interaction with F-actin.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						TCTGCAAGTGGAGCATCTGCT	0.438			NA											48	113					0	0	0.003214	0	0
ELMO1	9844	broad.mit.edu	37	7	36895239	36895239	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:36895239G>T	uc003tfk.1	-	22	2408	c.2101C>A	c.(2101-2103)CTG>ATG	p.L701M	ELMO1_uc003tfi.1_Missense_Mutation_p.L221M|ELMO1_uc003tfj.1_Missense_Mutation_p.L221M|ELMO1_uc011kbb.1_RNA|ELMO1_uc011kbc.1_Missense_Mutation_p.L605M|ELMO1_uc010kxg.1_Missense_Mutation_p.L701M	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	701					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						ATGTTTTCCAGGTCCAGGAGG	0.572			NA											39	131					8.69298e-16	1.42569e-15	0.006999	1	0
EPDR1	54749	broad.mit.edu	37	7	37960403	37960403	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:37960403G>A	uc003tfp.2	+	1	241	c.222G>A	c.(220-222)CCG>CCA	p.P74P	EPDR1_uc003tfq.2_Silent_p.P74P|EPDR1_uc010kxh.2_5'Flank	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	Error:Variant_position_missing_in_Q9UM22_after_alignment					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						AGAGGCCACCGAAGGGACAGG	0.672			NA											28	75					0	0	0.00632	0	0
POU6F2	11281	broad.mit.edu	37	7	39500316	39500316	+	Splice_Site	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:39500316T>A	uc003thb.1	+	9	1613	c.1571_splice	c.e9+2	p.R524_splice		NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1						central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						CATCTGCAGGTAACGCGCGCC	0.627			NA											6	9					0	0	0.00308	0	0
HECW1	23072	broad.mit.edu	37	7	43484130	43484130	+	Silent	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:43484130C>G	uc003tid.1	+	11	1964	c.1359C>G	c.(1357-1359)CCC>CCG	p.P453P	HECW1_uc011kbi.1_Silent_p.P453P	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	453					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						AGCCTGCCCCCAGTGCAGAAG	0.647			NA											7	13					0	0	0.00308	0	0
HECW1	23072	broad.mit.edu	37	7	43548638	43548638	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:43548638G>T	uc003tid.1	+	24	4542	c.3937G>T	c.(3937-3939)GGA>TGA	p.G1313*	HECW1_uc011kbi.1_Nonsense_Mutation_p.G1279*|uc003tig.1_RNA	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1313	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CCCTTACTATGGACTCTTTGA	0.493			NA											34	133					4.3181e-19	7.38055e-19	0.002836	1	0
HECW1	23072	broad.mit.edu	37	7	43581559	43581559	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:43581559G>C	uc003tid.1	+	26	4815	c.4210G>C	c.(4210-4212)GAC>CAC	p.D1404H	HECW1_uc011kbi.1_Missense_Mutation_p.D1370H	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1404	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						AGACATCTTAGACCTCACTTT	0.378			NA											8	114					0	0	0.008291	0	0
PURB	5814	broad.mit.edu	37	7	44924058	44924058	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:44924058C>A	uc003tme.2	-	1	903	c.890G>T	c.(889-891)GGC>GTC	p.G297V		NM_033224	NP_150093	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	297					regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding				0						GCCGCCGCTGCCCCCACCACG	0.597			NA											8	127					5.4927e-09	7.63426e-09	0.004482	1	0
ADCY1	107	broad.mit.edu	37	7	45753510	45753510	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:45753510G>T	uc003tne.3	+	20	3294	c.3276G>T	c.(3274-3276)ATG>ATT	p.M1092I		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	1092	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TGTGCCCCATGCCTGGCGTCT	0.637			NA											27	63					1.13719e-10	1.67106e-10	0.008361	1	0
PKD1L1	168507	broad.mit.edu	37	7	47944149	47944149	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:47944149C>A	uc003tny.1	-	12	1757	c.1757G>T	c.(1756-1758)AGG>ATG	p.R586M		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	586	Extracellular (Potential).|PKD 1.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CTTCTGCACCCTGATGACATG	0.547			NA											6	47					1.06961e-07	1.40907e-07	0.00308	1	0
SUN3	256979	broad.mit.edu	37	7	48046855	48046855	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:48046855C>A	uc003tof.2	-	6	496	c.399G>T	c.(397-399)CTG>CTT	p.L133L	SUN3_uc010kyq.2_Silent_p.L33L|SUN3_uc003tog.2_Silent_p.L133L|SUN3_uc011kcf.1_Silent_p.L121L	NM_152782	NP_689995	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 1	133	Potential.					integral to membrane				central_nervous_system(1)	1						GCAATGCCTTCAGGACATCTA	0.438			NA											13	69					1.5842e-08	2.18022e-08	0.001855	1	0
ABCA13	154664	broad.mit.edu	37	7	48315597	48315597	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:48315597T>A	uc003toq.2	+	17	6359	c.6334T>A	c.(6334-6336)TCA>ACA	p.S2112T	ABCA13_uc010kyr.2_Missense_Mutation_p.S1615T	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2112					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GGATTCACCGTCATTGAAGAC	0.338			NA											14	24					0	0	0.001855	0	0
FIGNL1	63979	broad.mit.edu	37	7	50514655	50514655	+	Nonsense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:50514655T>A	uc003tpc.2	-	4	708	c.331A>T	c.(331-333)AAA>TAA	p.K111*	FIGNL1_uc003tpb.2_5'UTR|FIGNL1_uc003tpd.2_Nonsense_Mutation_p.K111*|FIGNL1_uc003tpe.2_Nonsense_Mutation_p.K111*|FIGNL1_uc010kyy.2_Nonsense_Mutation_p.K111*	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	111					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				CTACTCATTTTGAAAACATTA	0.383			NA											14	110					0	0	0.003163	0	0
POM121L12	285877	broad.mit.edu	37	7	53104242	53104242	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:53104242C>A	uc003tpz.2	+	1	894	c.878C>A	c.(877-879)CCC>CAC	p.P293H		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	293											0						TCTGCTGGCCCCTTTGGCTCC	0.607			NA											18	56					5.03518e-11	7.47751e-11	0.007413	1	0
EGFR	1956	broad.mit.edu	37	7	55224350	55224350	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:55224350G>T	uc003tqk.2	+	9	1377	c.1131G>T	c.(1129-1131)AGG>AGT	p.R377S	EGFR_uc003tqh.2_Missense_Mutation_p.R377S|EGFR_uc003tqi.2_Missense_Mutation_p.R377S|EGFR_uc003tqj.2_Missense_Mutation_p.R377S|EGFR_uc010kzg.1_Missense_Mutation_p.R332S|EGFR_uc011kco.1_Missense_Mutation_p.R324S|EGFR_uc011kcp.1_RNA|EGFR_uc011kcq.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	377	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGGCATTTAGGGGGTGAGTCA	0.398			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			33	70					1.26612e-14	2.0417e-14	0.003271	1	0
GUSB	2990	broad.mit.edu	37	7	65429376	65429376	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:65429376G>A	uc003tun.2	-	11	1799	c.1723C>T	c.(1723-1725)CAA>TAA	p.Q575*	GUSB_uc011kdt.1_Nonsense_Mutation_p.Q429*	NM_000181	NP_000172	P08236	BGLR_HUMAN	glucuronidase, beta precursor	575					glycosaminoglycan catabolic process	lysosome	beta-glucuronidase activity|cation binding				0						CTGCGTTTTTGATCCAGACCC	0.443			NA											12	87					0	0	0.000978	0	0
FKBP6	8468	broad.mit.edu	37	7	72743399	72743399	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:72743399C>A	uc003tya.2	+	3	344	c.212C>A	c.(211-213)CCC>CAC	p.P71H	FKBP6_uc003twz.2_Intron|FKBP6_uc011kew.1_Missense_Mutation_p.P66H|FKBP6_uc010lbe.1_RNA|TRIM50_uc003txy.1_5'Flank|TRIM50_uc003txz.1_5'Flank	NM_003602	NP_003593	O75344	FKBP6_HUMAN	FK506 binding protein 6 isoform a	71	PPIase FKBP-type.				protein folding	membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				ATGGACAGACCCTTCGATTCT	0.438			NA											46	172					6.31075e-24	1.12353e-23	0.00361	1	0
HGF	3082	broad.mit.edu	37	7	81350104	81350104	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:81350104G>T	uc003uhl.2	-	10	1393	c.1228C>A	c.(1228-1230)CTA>ATA	p.L410I	HGF_uc003uhm.2_Missense_Mutation_p.L405I	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	410	Kringle 4.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						GAACATGTTAGTCCAGATCTT	0.338			NA											14	35					3.27435e-08	4.40009e-08	0.00245	1	0
PCLO	27445	broad.mit.edu	37	7	82585749	82585749	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:82585749C>T	uc003uhx.2	-	5	4809	c.4520G>A	c.(4519-4521)AGA>AAA	p.R1507K	PCLO_uc003uhv.2_Missense_Mutation_p.R1507K	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1438					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ATAAGGCTCTCTTCTAGTAGT	0.383			NA											6	101					0	0	0.00308	0	0
SEMA3D	223117	broad.mit.edu	37	7	84697561	84697561	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:84697561C>T	uc003uic.2	-	5	575	c.535G>A	c.(535-537)GGC>AGC	p.G179S	SEMA3D_uc010led.2_Missense_Mutation_p.G179S|SEMA3D_uc010lee.1_Missense_Mutation_p.G179S	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	179	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						TTCAGTCTGCCAGACTCCAAA	0.333	Ovarian(63;442 1191 17318 29975 31528)		NA											9	84					0	0	0.004482	0	0
SLC25A40	55972	broad.mit.edu	37	7	87483519	87483519	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:87483519C>A	uc003uje.2	-	5	615	c.264G>T	c.(262-264)TTG>TTT	p.L88F		NM_018843	NP_061331	Q8TBP6	S2540_HUMAN	mitochondrial carrier family protein	88	Solcar 1.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			haematopoietic_and_lymphoid_tissue(1)	1	Esophageal squamous(14;0.00202)					ATCACCTTACCAATGTTCCCT	0.318			NA											17	68					1.67942e-08	2.29485e-08	0.006122	1	0
MGC26647	219557	broad.mit.edu	37	7	88423497	88423497	+	Nonstop_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:88423497A>T	uc003ujv.2	-	2	942	c.760T>A	c.(760-762)TAG>AAG	p.*254K	ZNF804B_uc011khi.1_Intron	NM_152706	NP_689919	Q8TBZ9	CG062_HUMAN	hypothetical protein LOC219557	254											0	Esophageal squamous(14;0.00802)|all_hematologic(106;0.109)|Lung NSC(181;0.168)|all_lung(186;0.169)		STAD - Stomach adenocarcinoma(171;0.229)			TCTCAATCCTAGAAACGTGAA	0.378			NA											11	29					0	0	0.008291	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965846	88965846	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:88965846G>T	uc011khi.1	+	4	4088	c.3550G>T	c.(3550-3552)GCA>TCA	p.A1184S		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1184						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TTTGCCTGCTGCAGGGCCTAC	0.488			NA								HNSCC(36;0.09)			23	78					5.26018e-13	8.14138e-13	0.001882	1	0
ZNF804B	219578	broad.mit.edu	37	7	88966076	88966076	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:88966076C>T	uc011khi.1	+	4	4318	c.3780C>T	c.(3778-3780)CCC>CCT	p.P1260P		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1260						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CTGCACACCCCACTTTCTTAG	0.483			NA								HNSCC(36;0.09)			13	193					0	0	0.001855	0	0
CDK14	5218	broad.mit.edu	37	7	90377056	90377056	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:90377056G>T	uc003uky.2	+	4	652	c.430G>T	c.(430-432)GGA>TGA	p.G144*	CDK14_uc003ukt.1_Nonsense_Mutation_p.G98*|CDK14_uc003ukv.1_Nonsense_Mutation_p.G98*|CDK14_uc003uku.1_Nonsense_Mutation_p.G98*|CDK14_uc003ukx.1_Intron|CDK14_uc003ukz.1_Nonsense_Mutation_p.G126*|CDK14_uc010les.1_Nonsense_Mutation_p.G98*|CDK14_uc011khl.1_Intron	NM_012395	NP_036527	O94921	CDK14_HUMAN	PFTAIRE protein kinase 1	144	ATP (By similarity).|Protein kinase.				cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4						ACTAGGGGAAGGATCTTATGC	0.348	GBM(83;1228 1256 8311 16577 31299)		NA											15	232					4.96729e-08	6.61732e-08	0.008871	1	0
FZD1	8321	broad.mit.edu	37	7	90895699	90895699	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:90895699G>T	uc003ula.2	+	1	1917	c.1504G>T	c.(1504-1506)GGC>TGC	p.G502C		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	502	Helical; Name=5; (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			CCTGTTTATCGGCACGTCCTT	0.602			NA											12	169					1.08611e-07	1.42471e-07	0.000978	1	0
AKAP9	10142	broad.mit.edu	37	7	91672051	91672051	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:91672051G>A	uc003ulg.2	+	20	5353	c.5128G>A	c.(5128-5130)GAA>AAA	p.E1710K	AKAP9_uc003ulf.2_Missense_Mutation_p.E1710K|AKAP9_uc003uli.2_Missense_Mutation_p.E1335K	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1722					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CAGAAAACCTGAAGATGTGCC	0.318			NA	T	BRAF	papillary thyroid								16	169					0	0	0.007413	0	0
C7orf64	84060	broad.mit.edu	37	7	92164096	92164096	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:92164096A>G	uc003ulz.2	+	4	870	c.829A>G	c.(829-831)AGG>GGG	p.R277G	C7orf64_uc003uma.2_Missense_Mutation_p.R277G	NM_032120	NP_115496	Q5RL73	CG064_HUMAN	hypothetical protein LOC84060	277							nucleotide binding			ovary(2)	2						ATTTATGCCTAGGACAACACA	0.418			NA											8	40					0	0	0.00308	0	0
SAMD9	54809	broad.mit.edu	37	7	92731987	92731987	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:92731987C>T	uc003umf.2	-	3	3680	c.3424G>A	c.(3424-3426)GGG>AGG	p.G1142R	SAMD9_uc003umg.2_Missense_Mutation_p.G1142R	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1142						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GAAATGTTCCCGTTTCCTCCG	0.368			NA											16	226					0	0	0.00499	0	0
SAMD9	54809	broad.mit.edu	37	7	92733814	92733814	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:92733814T>A	uc003umf.2	-	3	1853	c.1597A>T	c.(1597-1599)ATA>TTA	p.I533L	SAMD9_uc003umg.2_Missense_Mutation_p.I533L	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	533						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			CTTGGCATTATGTCTTCATGT	0.408			NA											8	136					0	0	0.00308	0	0
SAMD9	54809	broad.mit.edu	37	7	92734749	92734749	+	Missense_Mutation	SNP	C	C	A	rs148603551		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:92734749C>A	uc003umf.2	-	3	918	c.662G>T	c.(661-663)CGA>CTA	p.R221L	SAMD9_uc003umg.2_Missense_Mutation_p.R221L	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	221						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TGAAGCAAATCGGAAAACCTC	0.398			NA											49	140					1.30409e-13	2.04929e-13	0.00361	1	0
PPP1R9A	55607	broad.mit.edu	37	7	94750039	94750039	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:94750039G>T	uc003unp.2	+	4	1826	c.1544G>T	c.(1543-1545)GGT>GTT	p.G515V	PPP1R9A_uc010lfj.2_Missense_Mutation_p.G515V|PPP1R9A_uc011kif.1_Missense_Mutation_p.G515V|PPP1R9A_uc003unq.2_Missense_Mutation_p.G515V|PPP1R9A_uc011kig.1_Missense_Mutation_p.G515V	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	515	PDZ.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			GATGGTCTTGGTATAAGTATT	0.418			NA								HNSCC(28;0.073)			36	172					4.62619e-21	8.0229e-21	0.004289	1	0
ASB4	51666	broad.mit.edu	37	7	95125234	95125234	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:95125234G>T	uc011kij.1	+	2	352	c.352G>T	c.(352-354)GCC>TCC	p.A118S	ASB4_uc003unx.2_Missense_Mutation_p.A118S	NM_016116	NP_057200	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box-containing protein 4	118	ANK 2.				intracellular signal transduction					central_nervous_system(1)	1	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			TTGTGAAATGGCCAATGTGGA	0.468			NA											17	64					6.49762e-13	1.00164e-12	0.006122	1	0
ACN9	57001	broad.mit.edu	37	7	96747046	96747046	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:96747046G>A	uc003uoo.3	+	1	1142	c.11G>A	c.(10-12)CGG>CAG	p.R4Q		NM_020186	NP_064571	Q9NRP4	ACN9_HUMAN	ACN9 homolog precursor	4					regulation of gluconeogenesis	mitochondrial intermembrane space					0	all_cancers(62;2.54e-08)|all_epithelial(64;2.24e-08)|Esophageal squamous(72;0.00507)|all_lung(186;0.154)|Lung NSC(181;0.159)					ATGCCGGGGCGGCACGTTTCT	0.647			NA											30	76					0	0	0.004289	0	0
PTCD1	26024	broad.mit.edu	37	7	99022694	99022694	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:99022694G>C	uc003uqh.2	-	6	1592	c.1461C>G	c.(1459-1461)ATC>ATG	p.I487M	PTCD1_uc011kiw.1_Missense_Mutation_p.I536M	NM_015545	NP_056360	O75127	PTCD1_HUMAN	pentatricopeptide repeat domain 1	487										ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			TGAGGGTCCTGATGTCGGGCT	0.647			NA											4	95					0	0	0.000602	0	0
CYP3A43	64816	broad.mit.edu	37	7	99447310	99447310	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:99447310C>T	uc003urx.1	+	7	766	c.663C>T	c.(661-663)CTC>CTT	p.L221L	CYP3A43_uc003ury.1_Silent_p.L221L|CYP3A43_uc003urz.1_Silent_p.L221L|CYP3A43_uc003usa.1_RNA|CYP3A43_uc010lgi.1_Intron|CYP3A43_uc003usb.1_Missense_Mutation_p.L84F	NM_057095	NP_476436	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A,	221			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)	CCTTTTTACTCTTAATATGTA	0.199			NA											12	36					0	0	0.001368	0	0
CYP3A43	64816	broad.mit.edu	37	7	99463537	99463537	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:99463537G>T	uc003urx.1	+	13	1528	c.1425G>T	c.(1423-1425)CTG>CTT	p.L475L	CYP3A43_uc003ury.1_Silent_p.L476L|CYP3A43_uc003urz.1_Nonstop_Mutation_p.*421L|CYP3A43_uc003usa.1_RNA|CYP3A43_uc010lgi.1_Silent_p.L365L|CYP3A43_uc003usb.1_Nonstop_Mutation_p.*281L	NM_057095	NP_476436	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A,	475			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)	AGATCCCACTGAAATTAGACA	0.343			NA											4	35					0.00024832	0.000283269	0.009096	1	0
C7orf51	222950	broad.mit.edu	37	7	100085977	100085977	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:100085977G>A	uc003uvd.1	+	4	792	c.633G>A	c.(631-633)CAG>CAA	p.Q211Q	C7orf51_uc003uve.1_5'UTR	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	211										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TGGGTGCCCAGGAAGAGCCTG	0.672			NA											6	95					0	0	0.001168	0	0
MUC17	140453	broad.mit.edu	37	7	100676223	100676223	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:100676223G>A	uc003uxp.1	+	3	1579	c.1526G>A	c.(1525-1527)GGA>GAA	p.G509E	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	509	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|6.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTAGTGAAGGAAGCACTCCA	0.502			NA											46	730					0	0	0.00361	0	0
MUC17	140453	broad.mit.edu	37	7	100679089	100679089	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:100679089C>A	uc003uxp.1	+	3	4445	c.4392C>A	c.(4390-4392)AAC>AAA	p.N1464K	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1464	Extracellular (Potential).|Ser-rich.|22.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTGTCAGCAACACGCCGGTGG	0.473			NA											32	473					5.8336e-16	9.60829e-16	0.003271	1	0
MUC17	140453	broad.mit.edu	37	7	100679784	100679784	+	Missense_Mutation	SNP	C	C	A	rs146239691		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:100679784C>A	uc003uxp.1	+	3	5140	c.5087C>A	c.(5086-5088)ACT>AAT	p.T1696N	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1696	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|26.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACAAGTATAACTGTCAGAACA	0.473			NA											119	235					9.55279e-52	1.82071e-51	0.00361	1	0
MUC17	140453	broad.mit.edu	37	7	100680500	100680500	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:100680500A>T	uc003uxp.1	+	3	5856	c.5803A>T	c.(5803-5805)ACC>TCC	p.T1935S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1935	Extracellular (Potential).|30.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACCTGTCAGCACCACAACAGT	0.488			NA											32	454					0	0	0.009535	0	0
MUC17	140453	broad.mit.edu	37	7	100683216	100683216	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:100683216C>T	uc003uxp.1	+	3	8572	c.8519C>T	c.(8518-8520)CCT>CTT	p.P2840L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2840	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|46.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACCAGCACACCTGTGACCACT	0.473			NA											130	480					0	0	0.00361	0	0
MUC17	140453	broad.mit.edu	37	7	100683456	100683456	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:100683456T>A	uc003uxp.1	+	3	8812	c.8759T>A	c.(8758-8760)ATC>AAC	p.I2920N	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2920	Extracellular (Potential).|47.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AGCATGCCAATCTCAACTCCT	0.478			NA											29	524					0	0	0.00632	0	0
RELN	5649	broad.mit.edu	37	7	103205894	103205894	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:103205894T>A	uc003vca.2	-	34	5201	c.5041A>T	c.(5041-5043)AGT>TGT	p.S1681C	RELN_uc010liz.2_Missense_Mutation_p.S1681C	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1681					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGCTGTACACTGTGGGAGTTG	0.483	NSCLC(146;835 1944 15585 22231 52158)		NA											10	27					0	0	0.006214	0	0
COG5	10466	broad.mit.edu	37	7	107053032	107053032	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:107053032T>C	uc003ved.2	-	7	1202	c.677A>G	c.(676-678)GAA>GGA	p.E226G	COG5_uc003vec.2_Missense_Mutation_p.E226G|COG5_uc003vee.2_Missense_Mutation_p.E226G	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	226					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						TAGATCATTTTCTATCACTTC	0.318			NA											17	57					0	0	0.004007	0	0
SLC26A3	1811	broad.mit.edu	37	7	107432339	107432339	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:107432339C>A	uc003ver.2	-	4	529	c.318G>T	c.(316-318)TTG>TTT	p.L106F	SLC26A3_uc003ves.2_Missense_Mutation_p.L71F	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	106	Helical; (Potential).				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						AGGATGCATACAACCCATAGA	0.458			NA											25	87					7.38237e-10	1.05855e-09	0.00632	1	0
LAMB1	3912	broad.mit.edu	37	7	107605093	107605093	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:107605093G>T	uc003vew.2	-	14	1937	c.1602C>A	c.(1600-1602)CAC>CAA	p.H534Q	LAMB1_uc003vev.2_Missense_Mutation_p.H558Q|LAMB1_uc003vex.2_Missense_Mutation_p.H534Q|LAMB1_uc010ljn.1_Missense_Mutation_p.H620Q	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	534	Laminin EGF-like 5; truncated.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCCAATCATGTGAGGCCGGC	0.562			NA											19	58					1.56452e-12	2.39738e-12	0.007413	1	0
PPP1R3A	5506	broad.mit.edu	37	7	113519998	113519998	+	Silent	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:113519998G>C	uc010ljy.1	-	4	1180	c.1149C>G	c.(1147-1149)TCC>TCG	p.S383S		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	383					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						CTCCCTTTACGGAGCTTTCTG	0.398			NA											61	179					0	0	0.00361	0	0
KCND2	3751	broad.mit.edu	37	7	119915076	119915076	+	Silent	SNP	C	C	T	rs138118192	by1000genomes	TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:119915076C>T	uc003vjj.1	+	1	1355	c.390C>T	c.(388-390)GGC>GGT	p.G130G		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	130	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					AAATCATCGGCGACTGCTGTT	0.587			NA											22	208					0	0	0.002299	0	0
C7orf58	79974	broad.mit.edu	37	7	120911417	120911417	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:120911417C>A	uc003vjq.3	+	22	3248	c.2801C>A	c.(2800-2802)ACA>AAA	p.T934K		NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	934						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					GTAGTTGACACATTCACTATA	0.363			NA											32	105					3.90053e-15	6.34299e-15	0.002445	1	0
PTPRZ1	5803	broad.mit.edu	37	7	121608163	121608163	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:121608163A>C	uc003vjy.2	+	3	678	c.283A>C	c.(283-285)ATT>CTT	p.I95L	PTPRZ1_uc003vjz.2_Missense_Mutation_p.I95L	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	95	Extracellular (Potential).|Alpha-carbonic anhydrase.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						AAACACATTCATTCATAACAC	0.303			NA											14	111					0	0	0.004007	0	0
SPAM1	6677	broad.mit.edu	37	7	123594379	123594379	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:123594379T>G	uc003vld.2	+	4	1157	c.755T>G	c.(754-756)TTG>TGG	p.L252W	SPAM1_uc003vle.2_Missense_Mutation_p.L252W|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Missense_Mutation_p.L252W|SPAM1_uc010lku.2_Missense_Mutation_p.L252W	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	252					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	CTCAGCTGGTTGTGGAATGAA	0.413			NA											5	141					0	0	0.000602	0	0
GRM8	2918	broad.mit.edu	37	7	126173818	126173818	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:126173818G>T	uc003vlr.2	-	8	1929	c.1618C>A	c.(1618-1620)CGC>AGC	p.R540S	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.R540S|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	540	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CCTTCACAGCGTTCACAGTGC	0.557			NA								HNSCC(24;0.065)			35	116					2.20474e-14	3.53676e-14	0.003755	1	0
ZNF800	168850	broad.mit.edu	37	7	127013541	127013541	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:127013541G>C	uc003vlx.1	-	5	2112	c.1849C>G	c.(1849-1851)CTT>GTT	p.L617V	ZNF800_uc003vlw.1_Missense_Mutation_p.L520V|ZNF800_uc003vly.1_Missense_Mutation_p.L617V|ZNF800_uc010lla.2_Missense_Mutation_p.L617V	NM_176814	NP_789784	Q2TB10	ZN800_HUMAN	zinc finger protein 800	617					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CATCTGTGAAGAGAAAAGTTT	0.358			NA											14	82					0	0	0.00245	0	0
FSCN3	29999	broad.mit.edu	37	7	127238614	127238614	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:127238614C>T	uc003vmd.1	+	4	1305	c.1086C>T	c.(1084-1086)CCC>CCT	p.P362P	FSCN3_uc011koh.1_Silent_p.P228P|FSCN3_uc010llc.1_Silent_p.P362P	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	362						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1						GCATTGCACCCAACAGCCTGC	0.567			NA											35	126					0	0	0.004878	0	0
CCDC136	64753	broad.mit.edu	37	7	128446346	128446346	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:128446346A>T	uc003vnv.1	+	8	1512	c.1145A>T	c.(1144-1146)CAG>CTG	p.Q382L	CCDC136_uc003vnu.1_Intron|CCDC136_uc003vnw.1_Intron|CCDC136_uc003vnx.1_Missense_Mutation_p.Q198L|CCDC136_uc010llq.1_5'UTR|CCDC136_uc003vny.1_5'UTR	NM_022742	NP_073579	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	382						integral to membrane	protein binding			ovary(2)	2						GATACTAGCCAGGATGAGCAG	0.463			NA											6	9					0	0	0.001168	0	0
FLNC	2318	broad.mit.edu	37	7	128493676	128493676	+	Splice_Site	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:128493676G>T	uc003vnz.3	+	38	6570	c.6361_splice	c.e38+1	p.G2121_splice	FLNC_uc003voa.3_Splice_Site_p.G2088_splice	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a						cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CACGTGCCTGGTAAGGCTCTG	0.607			NA											19	45					2.39187e-15	3.902e-15	0.008871	1	0
FLNC	2318	broad.mit.edu	37	7	128496863	128496863	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:128496863C>T	uc003vnz.3	+	45	7658	c.7449C>T	c.(7447-7449)AAC>AAT	p.N2483N	FLNC_uc003voa.3_Silent_p.N2450N	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2483	Filamin 22.|Interaction with INPPL1.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding	p.N2483N(1)		breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						TCAAGTTCAACGGTGCCCACA	0.597			NA											9	85					0	0	0.006214	0	0
LOC407835	407835	broad.mit.edu	37	7	128767070	128767070	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:128767070G>A	uc003voo.2	+	1	746	c.499G>A	c.(499-501)GAC>AAC	p.D167N		NR_002144				SubName: Full=cDNA FLJ35806 fis, clone TESTI2005987, highly similar to Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2); SubName: Full=Mitogen-activated protein kinase kinase 2, isoform CRA_d;												0						GATTCCCGAGGACATCCTGGG	0.587			NA											4	14					0	0	0.009096	0	0
C7orf45	136263	broad.mit.edu	37	7	129847928	129847928	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:129847928G>T	uc003vpp.2	+	1	225	c.178G>T	c.(178-180)GTC>TTC	p.V60F	TMEM209_uc003vpn.2_5'Flank|TMEM209_uc010lmc.1_5'Flank|TMEM209_uc003vpo.2_5'Flank	NM_145268	NP_660311	Q8WWF3	CG045_HUMAN	hypothetical protein LOC136263	60						integral to membrane					0	Melanoma(18;0.0435)					TAGGGCTTCTGTCTGGGTAGG	0.333			NA											30	90					5.60225e-13	8.66211e-13	0.009535	1	0
CPA2	1358	broad.mit.edu	37	7	129906792	129906792	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:129906792G>T	uc003vpq.2	+	1	90	c.71G>T	c.(70-72)GGA>GTA	p.G24V	CPA2_uc011kpc.1_Missense_Mutation_p.G24V	NM_001869	NP_001860	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic) precursor	24					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					ACATTTGTGGGGTAAGTTATG	0.403			NA											10	189					4.68919e-08	6.2631e-08	0.008291	1	0
CPA1	1357	broad.mit.edu	37	7	130025014	130025014	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:130025014C>T	uc003vpx.2	+	8	887	c.815C>T	c.(814-816)TCG>TTG	p.S272L	CPA1_uc003vpw.2_Missense_Mutation_p.S106L	NM_001868	NP_001859	P15085	CBPA1_HUMAN	carboxypeptidase A1 precursor	272					proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					AACCCCTGCTCGGAGACTTAC	0.547			NA											4	66					0	0	0.000602	0	0
PLXNA4	91584	broad.mit.edu	37	7	131865426	131865426	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:131865426C>A	uc003vra.3	-	19	3787	c.3558G>T	c.(3556-3558)GGG>GGT	p.G1186G		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1186	IPT/TIG 4.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						ACGGCTTCTCCCCAACCAGCA	0.602			NA											14	35					5.01169e-05	5.88712e-05	0.00499	1	0
AKR1B15	441282	broad.mit.edu	37	7	134260654	134260654	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:134260654C>A	uc011kpr.1	+	8	1017	c.718C>A	c.(718-720)CCC>ACC	p.P240T	AKR1B15_uc011kps.1_Missense_Mutation_p.P212T	NM_001080538	NP_001074007	C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	240	NADP (By similarity).						oxidoreductase activity			ovary(1)	1						GGCCTACAGCCCCCTGGGCTC	0.478			NA											8	77					0.000151284	0.000174646	0.001855	1	0
CNOT4	4850	broad.mit.edu	37	7	135106985	135106985	+	Nonsense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:135106985T>A	uc003vsv.1	-	3	599	c.292A>T	c.(292-294)AAA>TAA	p.K98*	CNOT4_uc003vss.2_Nonsense_Mutation_p.K98*|CNOT4_uc011kpz.1_Nonsense_Mutation_p.K98*|CNOT4_uc003vst.2_Nonsense_Mutation_p.K98*|CNOT4_uc003vsu.1_Nonsense_Mutation_p.K98*|CNOT4_uc011kpy.1_Nonsense_Mutation_p.K98*	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	98	Potential.				nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						GCCAAATGTTTGCGATTTTCT	0.388	Ovarian(51;766 1130 5502 35047 50875)		NA											33	99					0	0	0.004289	0	0
SLC13A4	26266	broad.mit.edu	37	7	135392916	135392916	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:135392916A>T	uc003vta.2	-	3	1000	c.311T>A	c.(310-312)CTG>CAG	p.L104Q	SLC13A4_uc003vtb.2_Missense_Mutation_p.L104Q|SLC13A4_uc003vtc.1_Missense_Mutation_p.L104Q	NM_012450	NP_036582	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate	104						integral to plasma membrane	sodium:sulfate symporter activity				0						GCGCTTATGCAGGTTCCACTT	0.597			NA											11	155					0	0	0.000978	0	0
DGKI	9162	broad.mit.edu	37	7	137075975	137075975	+	Silent	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:137075975A>G	uc003vtt.2	-	34	3190	c.3189T>C	c.(3187-3189)ACT>ACC	p.T1063T	DGKI_uc003vtu.2_Silent_p.T732T	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	1063					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						GTCAAACAGCAGTTTCCAGGT	0.532			NA											28	105					0	0	0.002836	0	0
CREB3L2	64764	broad.mit.edu	37	7	137590467	137590467	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:137590467C>A	uc003vtw.2	-	6	1291	c.896G>T	c.(895-897)CGG>CTG	p.R299L	CREB3L2_uc003vtx.1_Missense_Mutation_p.R299L|CREB3L2_uc003vtv.2_Missense_Mutation_p.R236L	NM_194071	NP_919047	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like	299	Cytoplasmic (Potential).|Basic motif.				chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	soft_tissue(158)|upper_aerodigestive_tract(1)|ovary(1)	160						GATCTTCCTCCGAATTTTCTT	0.517			NA	T	FUS	fibromyxoid sarcoma								13	268					5.50884e-06	6.74373e-06	0.001368	1	0
UBN2	254048	broad.mit.edu	37	7	138944042	138944042	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:138944042G>T	uc011kqr.1	+	5	831	c.831G>T	c.(829-831)GAG>GAT	p.E277D	UBN2_uc003vuv.2_5'UTR	NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	277	Lys-rich.									ovary(1)|skin(1)	2						ATGATATTGAGATGAAGAAGC	0.378			NA											27	58					5.6714e-07	7.2783e-07	0.002096	1	0
BRAF	673	broad.mit.edu	37	7	140481411	140481411	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:140481411C>A	uc003vwc.3	-	11	1458	c.1397G>T	c.(1396-1398)GGA>GTA	p.G466V		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	466	ATP (By similarity).|Protein kinase.		G -> V (in LNCR).|G -> A (in melanoma).|G -> E (in melanoma).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.G466V(12)|p.G466E(5)|p.G466A(3)|p.G466R(2)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCCAAATGATCCAGATCCAAT	0.378	Colon(40;35 892 2973 5743 27438)	G466V(NCIH1666_LUNG)|G466V(CAL12T_LUNG)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				30	110					2.42023e-17	4.06895e-17	0.003271	1	0
TAS2R38	5726	broad.mit.edu	37	7	141672757	141672757	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:141672757C>T	uc003vwx.1	-	1	817	c.733G>A	c.(733-735)GCC>ACC	p.A245T		NM_176817	NP_789787	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	245	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|skin(1)	2	Melanoma(164;0.0171)					GACTTGAGGGCTTTAATGTGG	0.502			NA											23	63					0	0	0.001882	0	0
Unknown	0	broad.mit.edu	37	7	142000998	142000998	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:142000998G>T	uc011kro.1	+	2	135	c.90G>T	c.(88-90)CAG>CAT	p.Q30H						SubName: Full=V_segment translation product; Flags: Fragment;												NA						CCAGCCATCAGGTCACACAGA	0.438			NA											5	29					8.12818e-05	9.43997e-05	0.001984	1	0
PRSS1	5644	broad.mit.edu	37	7	142460405	142460405	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:142460405A>T	uc003wak.2	+	4	595	c.578A>T	c.(577-579)AAG>ATG	p.K193M	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc003wam.2_Missense_Mutation_p.K133M	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	193	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			GAGGGAGGCAAGGATTCATGT	0.532			NA							Hereditary_Pancreatitis				14	198					0	0	0.003163	0	0
EPHB6	2051	broad.mit.edu	37	7	142568025	142568025	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:142568025G>T	uc011kst.1	+	18	3453	c.2666G>T	c.(2665-2667)GGA>GTA	p.G889V	EPHB6_uc011ksu.1_Missense_Mutation_p.G889V|EPHB6_uc003wbs.2_Missense_Mutation_p.G597V|EPHB6_uc003wbt.2_Missense_Mutation_p.G363V|EPHB6_uc003wbu.2_Missense_Mutation_p.G597V|EPHB6_uc003wbv.2_Missense_Mutation_p.G273V	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	889	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					TGTCCTCCTGGATTACATCTA	0.532			NA											50	296					2.9001e-28	5.31053e-28	0.00361	1	0
TRPV6	55503	broad.mit.edu	37	7	142572888	142572888	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:142572888G>A	uc003wbx.1	-	9	1368	c.1152C>T	c.(1150-1152)ATC>ATT	p.I384I	TRPV6_uc003wbw.1_Silent_p.I170I|TRPV6_uc010lou.1_Silent_p.I255I	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	384	Extracellular (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					CGACCAGCCGGATATCGTCCT	0.567			NA											5	106					0	0	0.000602	0	0
TRPV5	56302	broad.mit.edu	37	7	142626598	142626598	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:142626598T>G	uc003wby.1	-	4	676	c.412A>C	c.(412-414)ACC>CCC	p.T138P	TRPV5_uc003wbz.2_Missense_Mutation_p.T138P	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	138	ANK 3.|Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					GCCCTGCGGGTGAGCAGGGCA	0.602			NA											23	81					0	0	0.004656	0	0
PIP	5304	broad.mit.edu	37	7	142829214	142829214	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:142829214G>A	uc003wcf.1	+	1	41	c.5G>A	c.(4-6)CGC>CAC	p.R2H		NM_002652	NP_002643	P12273	PIP_HUMAN	prolactin-induced protein precursor	2						extracellular region	actin binding			ovary(1)	1	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		TCCAGCATGCGCTTGCTCCAG	0.552			NA											11	486					0	0	0.001855	0	0
TAS2R39	259285	broad.mit.edu	37	7	142881157	142881157	+	Missense_Mutation	SNP	G	G	A	rs150355894		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:142881157G>A	uc011ksw.1	+	1	646	c.646G>A	c.(646-648)GGG>AGG	p.G216R		NM_176881	NP_795362	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	216	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity	p.G216W(1)		skin(1)	1	Melanoma(164;0.059)					CTTTAACCTGGGGATTGTGAC	0.468			NA											37	97					0	0	0.00623	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147336213	147336213	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:147336213C>T	uc003weu.1	+	13	2429	c.1913C>T	c.(1912-1914)ACC>ATC	p.T638I		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	638	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AAAGTGTGGACCATAGTGTCT	0.473			NA								HNSCC(39;0.1)			17	180					0	0	0.010504	0	0
ZNF746	155061	broad.mit.edu	37	7	149172163	149172163	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:149172163T>A	uc003wfw.2	-	7	1518	c.1247A>T	c.(1246-1248)CAG>CTG	p.Q416L	ZNF746_uc010lpi.2_Missense_Mutation_p.Q417L	NM_152557	NP_689770	Q6NUN9	ZN746_HUMAN	zinc finger protein 746 isoform 2	416					negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|breast(1)	3	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			CCTTGGGGCCTGGCTGGGGTC	0.567			NA											4	17					0	0	0.009096	0	0
ZNF467	168544	broad.mit.edu	37	7	149467542	149467542	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:149467542C>A	uc003wgd.2	-	3	279	c.138G>T	c.(136-138)CTG>CTT	p.L46L	ZNF467_uc003wgc.2_Silent_p.L46L	NM_207336	NP_997219	Q7Z7K2	ZN467_HUMAN	zinc finger protein 467	46					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGCACACCCCCAGTGCTCTCT	0.448			NA											15	47					2.31682e-05	2.7594e-05	0.003163	1	0
SSPO	23145	broad.mit.edu	37	7	149483249	149483249	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:149483249G>T	uc010lpk.2	+	23	3317	c.3317G>T	c.(3316-3318)CGT>CTT	p.R1106L	SSPO_uc010lpl.1_Missense_Mutation_p.R356L	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1106	VWFD 3.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CTGAGCCTGCGTCGTGCTGGC	0.652			NA											4	14					0.000602214	0.000674971	0.000602	1	0
SSPO	23145	broad.mit.edu	37	7	149500790	149500790	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:149500790G>T	uc010lpk.2	+	56	8108	c.8108G>T	c.(8107-8109)GGG>GTG	p.G2703V		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2703					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGTGAGAAGGGGGAGTTGCTG	0.697			NA											4	20					0.00909568	0.00983662	0.009096	1	0
SSPO	23145	broad.mit.edu	37	7	149509187	149509187	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:149509187C>G	uc010lpk.2	+	69	9733	c.9733C>G	c.(9733-9735)CTC>GTC	p.L3245V		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	3245	TSP type-1 11.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGAGCCATGTCTCCTGCAGGG	0.687			NA											4	56					0	0	0.000602	0	0
GIMAP8	155038	broad.mit.edu	37	7	150164204	150164204	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:150164204G>T	uc003whj.2	+	2	748	c.418G>T	c.(418-420)GGG>TGG	p.G140W		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	140						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		GGATGATTTGGGGGATGACTT	0.453			NA											20	65					2.94398e-08	3.97347e-08	0.007413	1	0
TMEM176B	28959	broad.mit.edu	37	7	150490383	150490383	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:150490383G>A	uc003wht.3	-	5	559	c.393C>T	c.(391-393)CTC>CTT	p.L131L	TMEM176B_uc003whu.3_Silent_p.L131L|TMEM176B_uc003whv.3_Silent_p.L94L|TMEM176B_uc003whw.3_Silent_p.L131L	NM_001101313	NP_001094783	Q3YBM2	T176B_HUMAN	transmembrane protein 176B isoform a	131	Helical; (Potential).				cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTGCCAGGGTGAGCAGGCTGG	0.517			NA											13	26					0	0	0.00245	0	0
MLL3	58508	broad.mit.edu	37	7	151945260	151945260	+	Silent	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:151945260T>C	uc003wla.2	-	14	2478	c.2259A>G	c.(2257-2259)TCA>TCG	p.S753S		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	753					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CTCCTTGGTATGAAACATCTT	0.393	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								11	239					0	0	0.008291	0	0
HTR5A	3361	broad.mit.edu	37	7	154862664	154862664	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:154862664G>C	uc003wlu.1	+	1	119	c.55G>C	c.(55-57)GAG>CAG	p.E19Q	uc011kvt.1_Intron|uc003wlt.2_Intron	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	19	Extracellular (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		CTCCCCTTTGGAGACCAACCA	0.597			NA											22	120					0	0	0.00278	0	0
HTR5A	3361	broad.mit.edu	37	7	154862942	154862942	+	Silent	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:154862942G>C	uc003wlu.1	+	1	397	c.333G>C	c.(331-333)CGG>CGC	p.R111R	uc011kvt.1_Silent_p.L24L|uc003wlt.2_Silent_p.L24L	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	111	Extracellular (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		AGCTAGGTCGGAGGCTGTGCC	0.667			NA											8	30					0	0	0.004482	0	0
HTR5A	3361	broad.mit.edu	37	7	154876005	154876005	+	Missense_Mutation	SNP	C	C	A	rs145653373		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:154876005C>A	uc003wlu.1	+	2	946	c.882C>A	c.(880-882)TTC>TTA	p.F294L		NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	294	Helical; Name=6; (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		TTGGCGTGTTCGTGCTCTGCT	0.622			NA											34	111					8.4185e-14	1.32697e-13	0.002445	1	0
HTR5A	3361	broad.mit.edu	37	7	154876017	154876017	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:154876017G>T	uc003wlu.1	+	2	958	c.894G>T	c.(892-894)TGG>TGT	p.W298C		NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	298	Helical; Name=6; (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		TGCTCTGCTGGATCCCCTTCT	0.607			NA											38	132					3.21399e-22	5.6373e-22	0.004878	1	0
RP1L1	94137	broad.mit.edu	37	8	10467868	10467868	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:10467868G>A	uc003wtc.2	-	4	3969	c.3740C>T	c.(3739-3741)CCA>CTA	p.P1247L		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1247					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CAGATCCCCTGGGCTCTCATA	0.552			NA											12	45					0	0	0.000978	0	0
DOK2	9046	broad.mit.edu	37	8	21767420	21767421	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:21767420_21767421CC>AA	uc003wzy.1	-	5	733_734	c.640_641GG>TT	c.(640-642)GGC>TTC	p.G214F	DOK2_uc003wzx.1_Missense_Mutation_p.G214F|DOK2_uc003wzz.1_Missense_Mutation_p.G60F|DOK2_uc010lth.1_Missense_Mutation_p.G60F	NM_003974	NP_003965	O60496	DOK2_HUMAN	docking protein 2	214	IRS-type PTB.				blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding				0				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		GCAGCGACGGCCTGCCTCAAAG	0.49			NA											3	33					0	0	0.004672	0	0
PTK2B	2185	broad.mit.edu	37	8	27295394	27295394	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:27295394A>C	uc003xfn.1	+	23	2448	c.1640A>C	c.(1639-1641)CAC>CCC	p.H547P	PTK2B_uc003xfo.1_Missense_Mutation_p.H547P|PTK2B_uc003xfp.1_Missense_Mutation_p.H547P|PTK2B_uc003xfq.1_Missense_Mutation_p.H547P|PTK2B_uc003xfr.1_Missense_Mutation_p.H293P	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	547	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		AACTGCGTGCACAGGTAGGGG	0.493			NA											5	25					0	0	0.000602	0	0
TEX15	56154	broad.mit.edu	37	8	30705979	30705979	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:30705979G>T	uc003xil.2	-	1	555	c.555C>A	c.(553-555)TCC>TCA	p.S185S		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	185										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AAGCATTACCGGACTCCTGTT	0.413			NA											4	55					2.56e-06	3.19223e-06	0.009096	1	0
WRN	7486	broad.mit.edu	37	8	30977913	30977913	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:30977913G>T	uc003xio.3	+	21	3391	c.2603G>T	c.(2602-2604)TGG>TTG	p.W868L	WRN_uc010lvk.2_Missense_Mutation_p.W335L	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	868	Helicase C-terminal.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		CACGTCCTCTGGGCTCCTGCA	0.368	Ovarian(18;161 598 2706 14834 27543)		NA	Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				8	55					0.00307968	0.0033804	0.00308	1	0
UNC5D	137970	broad.mit.edu	37	8	35541233	35541233	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:35541233G>A	uc003xjr.1	+	5	1067	c.739G>A	c.(739-741)GTT>ATT	p.V247I	UNC5D_uc003xjs.1_Missense_Mutation_p.V242I|UNC5D_uc003xjt.1_Missense_Mutation_p.V16I	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	247	Extracellular (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		GTCGGCCACTGTTGTGGTCTA	0.502			NA											6	24					0	0	0.001984	0	0
KCNU1	157855	broad.mit.edu	37	8	36671868	36671868	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:36671868C>T	uc010lvw.2	+	8	963	c.876C>T	c.(874-876)TTC>TTT	p.F292F	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	292	Helical; Name=Segment S6; (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		GACGGACCTTCATCATGTTCT	0.353			NA											8	20					0	0	0.008291	0	0
KCNU1	157855	broad.mit.edu	37	8	36766906	36766906	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:36766906G>A	uc010lvw.2	+	21	2271	c.2184G>A	c.(2182-2184)CCG>CCA	p.P728P	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	728	Segment S9.|Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ACTCAGCCCCGATGGGGCTTC	0.468			NA											39	276					0	0	0.003214	0	0
ADAM2	2515	broad.mit.edu	37	8	39646227	39646227	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:39646227G>T	uc003xnj.2	-	8	678	c.603C>A	c.(601-603)GTC>GTA	p.V201V	ADAM2_uc003xnk.2_Silent_p.V182V|ADAM2_uc011lck.1_Silent_p.V201V|ADAM2_uc003xnl.2_Intron	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	201	Extracellular (Potential).|Peptidase M12B.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CTTTTTGAGCGACAACAGTTG	0.279			NA											4	28					3.59834e-05	4.24306e-05	0.001168	1	0
ANK1	286	broad.mit.edu	37	8	41542077	41542077	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:41542077G>T	uc003xok.2	-	37	4606	c.4522C>A	c.(4522-4524)CCC>ACC	p.P1508T	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.P824T|ANK1_uc003xoi.2_Missense_Mutation_p.P1508T|ANK1_uc003xoj.2_Missense_Mutation_p.P1508T|ANK1_uc003xol.2_Missense_Mutation_p.P1508T|ANK1_uc003xom.2_Missense_Mutation_p.P1549T	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1508	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			ATCTGGGAGGGTGACAGCGAG	0.607			NA											9	55					0.00448238	0.00488872	0.004482	1	0
POTEA	340441	broad.mit.edu	37	8	43211972	43211972	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:43211972C>A	uc003xpz.1	+	12	1474	c.1431C>A	c.(1429-1431)AGC>AGA	p.S477R	POTEA_uc003xqa.1_Missense_Mutation_p.S431R	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	477	Potential.									ovary(1)	1						TCAAAAATAGCCACTATGAGC	0.363			NA											6	38					0.00198382	0.00218689	0.001984	1	0
PXDNL	137902	broad.mit.edu	37	8	52232456	52232456	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:52232456G>T	uc003xqu.3	-	23	4488	c.4387C>A	c.(4387-4389)CGC>AGC	p.R1463S	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1463					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TTTTATTAGCGCTTCTCTGGG	0.458			NA											6	36					0.00198382	0.00218689	0.001984	1	0
RAB2A	5862	broad.mit.edu	37	8	61484660	61484660	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:61484660G>T	uc003xud.1	+	3	382	c.174G>T	c.(172-174)CAG>CAT	p.Q58H	RAB2A_uc011lef.1_Missense_Mutation_p.Q34H	NM_002865	NP_002856	P61019	RAB2A_HUMAN	RAB2A, member RAS oncogene family	58					ER to Golgi vesicle-mediated transport|protein transport|small GTPase mediated signal transduction	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|melanosome	GDP binding|GTP binding|GTPase activity				0			BRCA - Breast invasive adenocarcinoma(89;0.0805)			TAAAACTTCAGATATGGGATA	0.318			NA											11	19					9.31168e-06	1.1336e-05	0.001855	1	0
COPS5	10987	broad.mit.edu	37	8	67958151	67958151	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:67958151C>A	uc003xxe.2	-	7	1147	c.816G>T	c.(814-816)AAG>AAT	p.K272N	COPS5_uc003xxd.2_Missense_Mutation_p.K208N|COPS5_uc003xxf.2_Missense_Mutation_p.K317N|COPS5_uc010lyu.1_RNA	NM_006837	NP_006828	Q92905	CSN5_HUMAN	COP9 signalosome subunit 5	272					cullin deneddylation|transcription from RNA polymerase II promoter	eukaryotic translation initiation factor 3 complex|signalosome	metal ion binding|metallopeptidase activity|protein binding|transcription coactivator activity|translation initiation factor activity			ovary(1)|skin(1)	2	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00389)|OV - Ovarian serous cystadenocarcinoma(28;0.00691)|all cancers(69;0.0205)|BRCA - Breast invasive adenocarcinoma(89;0.153)			ACTGCTCTAACTTTTCAGACA	0.433			NA											25	71					1.64293e-13	2.56865e-13	0.00333	1	0
SLCO5A1	81796	broad.mit.edu	37	8	70744859	70744859	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:70744859G>T	uc003xyl.2	-	2	757	c.50C>A	c.(49-51)GCG>GAG	p.A17E	SLCO5A1_uc010lzb.2_Missense_Mutation_p.A17E|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Missense_Mutation_p.A17E|SLCO5A1_uc010lzc.2_Missense_Mutation_p.A17E	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	17	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			AGTGGCCGGCGCCTCCAGCTG	0.632			NA									OREG0018815	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	48					8.10497e-08	1.07323e-07	0.010504	1	0
KCNB2	9312	broad.mit.edu	37	8	73848595	73848595	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:73848595G>T	uc003xzb.2	+	3	1593	c.1005G>T	c.(1003-1005)TTG>TTT	p.L335F		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	335	Helical; Name=Segment S5; (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			ACAATGAATTGGGCTTGTTGA	0.473			NA											35	94					1.414e-09	1.9996e-09	0.003755	1	0
CRISPLD1	83690	broad.mit.edu	37	8	75932315	75932315	+	Splice_Site	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:75932315G>T	uc003yan.2	+	12	1619	c.1244_splice	c.e12+1	p.R415_splice	CRISPLD1_uc011lfk.1_Splice_Site_p.R227_splice|CRISPLD1_uc011lfl.1_Splice_Site_p.R227_splice	NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain							extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			ATTGCCCAAGGTAAACCAGTG	0.408			NA											20	31					1.50039e-11	2.24986e-11	0.001882	1	0
ZFHX4	79776	broad.mit.edu	37	8	77690640	77690640	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:77690640T>A	uc003yav.2	+	4	3599	c.3212T>A	c.(3211-3213)ATC>AAC	p.I1071N	ZFHX4_uc003yau.1_Missense_Mutation_p.I1097N|ZFHX4_uc003yaw.1_Missense_Mutation_p.I1071N	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1071						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTCAGTGAGATCTTTTTTGTT	0.502			NA								HNSCC(33;0.089)			15	131					0	0	0.00499	0	0
ZFHX4	79776	broad.mit.edu	37	8	77763548	77763548	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:77763548C>A	uc003yav.2	+	10	4643	c.4256C>A	c.(4255-4257)CCC>CAC	p.P1419H	ZFHX4_uc003yau.1_Missense_Mutation_p.P1464H|ZFHX4_uc003yaw.1_Missense_Mutation_p.P1419H	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1419						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCCTCCTTGCCCGTGAATGGA	0.512			NA								HNSCC(33;0.089)			9	22					0.000274275	0.000311722	0.004482	1	0
ZFHX4	79776	broad.mit.edu	37	8	77767649	77767649	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:77767649G>T	uc003yav.2	+	10	8744	c.8357G>T	c.(8356-8358)GGA>GTA	p.G2786V	ZFHX4_uc003yau.1_Missense_Mutation_p.G2831V|ZFHX4_uc003yaw.1_Missense_Mutation_p.G2786V	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2786						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GGAAGTTCCGGAGATGTGAAA	0.488			NA								HNSCC(33;0.089)			10	29					0.000442599	0.000499343	0.006214	1	0
MMP16	4325	broad.mit.edu	37	8	89086857	89086857	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:89086857C>A	uc003yeb.3	-	7	1480	c.1198G>T	c.(1198-1200)GAC>TAC	p.D400Y	MMP16_uc003yec.2_Missense_Mutation_p.D400Y	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	400	Hemopexin-like 2.|Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						AAATTCCCGTCGCTATTTTCA	0.413			NA											11	62					6.40141e-05	7.49101e-05	0.000978	1	0
DECR1	1666	broad.mit.edu	37	8	91063968	91063968	+	Splice_Site	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:91063968G>T	uc003yek.1	+	9	1089	c.948_splice	c.e9+1	p.K316_splice	DECR1_uc011lgc.1_Splice_Site_p.K307_splice|DECR1_uc011lgd.1_Splice_Site	NM_001359	NP_001350	Q16698	DECR_HUMAN	2,4-dienoyl CoA reductase 1 precursor						fatty acid beta-oxidation|protein homotetramerization	mitochondrial matrix|nucleus|plasma membrane	2,4-dienoyl-CoA reductase (NADPH) activity|NADPH binding|oxidoreductase activity, acting on NADH or NADPH				0			BRCA - Breast invasive adenocarcinoma(11;0.00953)			CCTGAGAAAGGTAATGCTTTT	0.328			NA											13	27					1.05317e-09	1.50035e-09	0.00245	1	0
C8orf37	157657	broad.mit.edu	37	8	96281413	96281413	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:96281413G>A	uc003yho.1	-	1	25	c.5C>T	c.(4-6)GCG>GTG	p.A2V		NM_177965	NP_808880	Q96NL8	CH037_HUMAN	hypothetical protein LOC157657	2											0	Breast(36;3.41e-05)					CAGGTCCTCCGCCATCTTGAA	0.612			NA									OREG0018873	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	140					0	0	0.003163	0	0
MATN2	4147	broad.mit.edu	37	8	99042728	99042728	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:99042728G>C	uc003yic.2	+	15	2626	c.2395G>C	c.(2395-2397)GAG>CAG	p.E799Q	MATN2_uc010mbh.1_Missense_Mutation_p.E758Q|MATN2_uc003yid.2_Missense_Mutation_p.E799Q|MATN2_uc003yie.1_Missense_Mutation_p.E799Q|MATN2_uc010mbi.1_Missense_Mutation_p.E632Q|MATN2_uc010mbj.1_Missense_Mutation_p.E160Q|RPL30_uc010mbk.1_Intron	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	799	VWFA 2.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			AAAAGCCATTGAGGAGGAACT	0.438			NA											11	24					0	0	0.008291	0	0
POP1	10940	broad.mit.edu	37	8	99169910	99169910	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:99169910G>A	uc003yij.3	+	16	2586	c.2486G>A	c.(2485-2487)GGC>GAC	p.G829D	POP1_uc011lgv.1_Missense_Mutation_p.G829D|POP1_uc003yik.2_Missense_Mutation_p.G829D	NM_001145860	NP_001139332	Q99575	POP1_HUMAN	processing of precursor 1	829					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			AGTCGGGGAGGCCGGCGAGCT	0.567			NA											20	39					0	0	0.001882	0	0
RGS22	26166	broad.mit.edu	37	8	100994230	100994230	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:100994230C>G	uc003yjb.1	-	22	3490	c.3295G>C	c.(3295-3297)GAG>CAG	p.E1099Q	RGS22_uc003yja.1_Missense_Mutation_p.E918Q|RGS22_uc003yjc.1_Missense_Mutation_p.E1087Q	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	1099	RGS 2.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TGGGCTTGCTCTACTGGAATG	0.388			NA											33	150					0	0	0.002836	0	0
SPAG1	6674	broad.mit.edu	37	8	101232595	101232595	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:101232595G>A	uc003yjh.1	+	13	1710	c.1624G>A	c.(1624-1626)GTG>ATG	p.V542M	SPAG1_uc003yji.1_Missense_Mutation_p.V542M	NM_172218	NP_757367	Q07617	SPAG1_HUMAN	sperm associated antigen 1	542	TPR 6.				single fertilization	cytoplasm	GTP binding|hydrolase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		GAAAGCTTATGTGGATTATAA	0.428			NA											6	101					0	0	0.001168	0	0
NCALD	83988	broad.mit.edu	37	8	102705114	102705114	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:102705114T>C	uc003yke.2	-	3	758	c.389A>G	c.(388-390)AAG>AGG	p.K130R	NCALD_uc003ykf.2_Missense_Mutation_p.K130R|NCALD_uc003ykg.2_Missense_Mutation_p.K130R|NCALD_uc003ykh.2_Missense_Mutation_p.K130R|NCALD_uc003yki.2_Missense_Mutation_p.K130R|NCALD_uc003ykj.2_Missense_Mutation_p.K130R|NCALD_uc003ykk.2_Missense_Mutation_p.K130R|NCALD_uc003ykl.2_Missense_Mutation_p.K130R	NM_032041	NP_114430	P61601	NCALD_HUMAN	neurocalcin delta	130	EF-hand 3.				synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding				0	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)			GGAAACCATCTTATAGATTGC	0.453			NA											17	61					0	0	0.006122	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110448582	110448582	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:110448582C>T	uc003yne.2	+	30	3625	c.3521C>T	c.(3520-3522)ACT>ATT	p.T1174I		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1174	Extracellular (Potential).|IPT/TIG 5.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACTCTACTGACTTTATCTGGA	0.318			NA								HNSCC(38;0.096)			23	74					0	0	0.003954	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110464485	110464485	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:110464485C>A	uc003yne.2	+	42	6587	c.6483C>A	c.(6481-6483)ATC>ATA	p.I2161I		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2161	IPT/TIG 14.|Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTGTCCACATCAGAGGTGTCG	0.453			NA								HNSCC(38;0.096)			27	52					9.65021e-13	1.48465e-12	0.002096	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110497320	110497320	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:110497320G>C	uc003yne.2	+	58	9728	c.9624G>C	c.(9622-9624)CAG>CAC	p.Q3208H		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3208	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATTTCCACCAGACAGAAACAA	0.318			NA								HNSCC(38;0.096)			26	48					0	0	0.00333	0	0
CSMD3	114788	broad.mit.edu	37	8	113301627	113301627	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:113301627C>A	uc003ynu.2	-	57	9274	c.9115G>T	c.(9115-9117)GGC>TGC	p.G3039C	CSMD3_uc003yns.2_Missense_Mutation_p.G2241C|CSMD3_uc003ynt.2_Missense_Mutation_p.G2999C|CSMD3_uc011lhx.1_Missense_Mutation_p.G2870C	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3039	Sushi 21.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTCCAATGGCCATTCAATTGG	0.423			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			60	95					3.39796e-24	6.05655e-24	0.00361	1	0
CSMD3	114788	broad.mit.edu	37	8	113668414	113668414	+	Silent	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:113668414A>T	uc003ynu.2	-	18	3132	c.2973T>A	c.(2971-2973)CGT>CGA	p.R991R	CSMD3_uc003yns.2_Silent_p.R263R|CSMD3_uc003ynt.2_Silent_p.R951R|CSMD3_uc011lhx.1_Silent_p.R887R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	991	Extracellular (Potential).|CUB 5.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CATTATTGGAACGACTGTTGT	0.323			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			17	76					0	0	0.007413	0	0
KLHL38	340359	broad.mit.edu	37	8	124664765	124664765	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:124664765G>T	uc003yqs.1	-	1	426	c.402C>A	c.(400-402)AGC>AGA	p.S134R		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	134											0						CCAGGCAGTTGCTGGGGGCCA	0.582			NA											25	34					8.24728e-16	1.35403e-15	0.004656	1	0
ASAP1	50807	broad.mit.edu	37	8	131414157	131414157	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:131414157A>T	uc003yta.1	-	1	61	c.33T>A	c.(31-33)TTT>TTA	p.F11L	ASAP1_uc011liw.1_5'UTR	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	11					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						CTCTCGACGAAAAACTGGAGA	0.517			NA											43	80					0	0	0.00361	0	0
TG	7038	broad.mit.edu	37	8	133885314	133885314	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:133885314G>C	uc003ytw.2	+	5	527	c.486G>C	c.(484-486)AGG>AGC	p.R162S		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	162	Thyroglobulin type-1 3.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TAGGTCCAAGGAGCTGTGAAA	0.408			NA											16	30					0	0	0.00499	0	0
ZFAT	57623	broad.mit.edu	37	8	135524846	135524846	+	Splice_Site	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:135524846T>C	uc003yup.2	-	14	3410	c.3235_splice	c.e14-1	p.T1079_splice	ZFAT_uc011ljj.1_Splice_Site_p.T198_splice|ZFAT_uc003yun.2_Splice_Site_p.T1067_splice|ZFAT_uc003yuo.2_Splice_Site_p.T1067_splice|ZFAT_uc010meh.2_Intron|ZFAT_uc010mei.2_Splice_Site|ZFAT_uc003yuq.2_Splice_Site_p.T1067_splice|ZFAT_uc010mej.2_Splice_Site_p.T1017_splice	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			TGTTGCTGTCTAAATAAAAAC	0.468			NA											7	135					0	0	0.001984	0	0
FAM135B	51059	broad.mit.edu	37	8	139158255	139158255	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:139158255C>A	uc003yuy.2	-	15	3658	c.3487G>T	c.(3487-3489)GAA>TAA	p.E1163*	FAM135B_uc003yux.2_Nonsense_Mutation_p.E1064*|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Nonsense_Mutation_p.E725*|FAM135B_uc003yvb.2_Missense_Mutation_p.R690I	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1163										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AGCCCCAGTTCTATGAAAGTC	0.448			NA								HNSCC(54;0.14)			13	142					2.32078e-09	3.2759e-09	0.003163	1	0
KCNK9	51305	broad.mit.edu	37	8	140631039	140631039	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:140631039G>T	uc003yvf.1	-	2	651	c.587C>A	c.(586-588)ACG>AAG	p.T196K	KCNK9_uc003yvg.1_Missense_Mutation_p.T196K|KCNK9_uc003yve.1_RNA	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	196						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			GGTAGTCAACGTGATGAAGCA	0.577			NA											33	40					8.4185e-14	1.32697e-13	0.002445	1	0
CYP11B2	1585	broad.mit.edu	37	8	143994039	143994039	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:143994039G>T	uc003yxk.1	-	8	1308	c.1305C>A	c.(1303-1305)GGC>GGA	p.G435G		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	435					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GGAAGTTCCTGCCGGAGCCCC	0.627			NA							Familial_Hyperaldosteronism_type_I				29	51					1.32143e-28	2.42551e-28	0.00632	1	0
ZFP41	286128	broad.mit.edu	37	8	144332450	144332450	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:144332450G>T	uc003yxw.2	+	2	795	c.437G>T	c.(436-438)GGG>GTG	p.G146V	ZFP41_uc003yxv.2_RNA	NM_173832	NP_776193	Q8N8Y5	ZFP41_HUMAN	zinc finger protein 41 homolog	146	C2H2-type 3.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G146G(1)		ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.6e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			TTCAAATGCGGGGAGTGCGGG	0.582			NA											35	82					6.53348e-20	1.12294e-19	0.003755	1	0
FAM83H	286077	broad.mit.edu	37	8	144810181	144810181	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr8:144810181C>G	uc003yzk.2	-	5	1519	c.1450G>C	c.(1450-1452)GCG>CCG	p.A484P	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	484					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TCCGGGTCCGCGAAACCCGCG	0.731			NA											10	15					0	0	0.008291	0	0
SMARCA2	6595	broad.mit.edu	37	9	2110342	2110342	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:2110342A>T	uc003zhc.2	+	24	3480	c.3381A>T	c.(3379-3381)AGA>AGT	p.R1127S	SMARCA2_uc003zhd.2_Missense_Mutation_p.R1127S|SMARCA2_uc010mha.2_Missense_Mutation_p.R1060S	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1127	Helicase C-terminal.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		TGAGCACAAGAGCTGGTGGCC	0.502			NA											25	73					0	0	0.00333	0	0
KIAA1432	57589	broad.mit.edu	37	9	5754900	5754900	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:5754900G>A	uc003zji.2	+	14	1518	c.1425G>A	c.(1423-1425)GCG>GCA	p.A475A	KIAA1432_uc003zjh.2_Silent_p.A475A|KIAA1432_uc003zjl.3_Silent_p.A438A|KIAA1432_uc003zjj.1_Silent_p.A17A	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	554						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		TGGTCCTTGCGTGTTATAACA	0.289			NA											5	81					0	0	0.001984	0	0
PTPRD	5789	broad.mit.edu	37	9	8518099	8518099	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:8518099G>T	uc003zkk.2	-	20	2003	c.1292C>A	c.(1291-1293)TCG>TAG	p.S431*	PTPRD_uc003zkp.2_Nonsense_Mutation_p.S431*|PTPRD_uc003zkq.2_Nonsense_Mutation_p.S431*|PTPRD_uc003zkr.2_Nonsense_Mutation_p.S425*|PTPRD_uc003zks.2_Nonsense_Mutation_p.S421*|PTPRD_uc003zkl.2_Nonsense_Mutation_p.S431*|PTPRD_uc003zkm.2_Nonsense_Mutation_p.S418*|PTPRD_uc003zkn.2_Nonsense_Mutation_p.S431*|PTPRD_uc003zko.2_Nonsense_Mutation_p.S428*	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	431	Fibronectin type-III 2.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AATGGTGGTCGAACTCAACAT	0.502			NA								TSP Lung(15;0.13)			8	203					0.000157383	0.000180738	0.00308	1	0
TYRP1	7306	broad.mit.edu	37	9	12704606	12704606	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:12704606G>T	uc003zkv.3	+	6	1340	c.1162G>T	c.(1162-1164)GGG>TGG	p.G388W		NM_000550	NP_000541	P17643	TYRP1_HUMAN	tyrosinase-related protein 1 precursor	388	Lumenal, melanosome (Potential).				melanin biosynthetic process	clathrin-coated endocytic vesicle membrane|endosome membrane|integral to membrane|melanosome membrane	copper ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen|protein heterodimerization activity|protein homodimerization activity			lung(1)	1		all_cancers(3;3.1e-05)|all_lung(3;1.7e-06)|Lung NSC(3;2.09e-06)|all_epithelial(3;0.000695)|all_hematologic(3;0.0033)|Acute lymphoblastic leukemia(23;0.0744)		GBM - Glioblastoma multiforme(50;9.85e-06)		GAATGGAACAGGGGGACAAAC	0.468			NA							Oculocutaneous_Albinism				38	93					6.19805e-25	1.11118e-24	0.005524	1	0
MPDZ	8777	broad.mit.edu	37	9	13150681	13150681	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:13150681T>A	uc010mia.1	-	24	3516	c.3459A>T	c.(3457-3459)GAA>GAT	p.E1153D	MPDZ_uc010mhx.2_Missense_Mutation_p.E45D|MPDZ_uc011lmm.1_Missense_Mutation_p.E45D|MPDZ_uc003zkz.3_Intron|MPDZ_uc010mhy.2_Missense_Mutation_p.E1153D|MPDZ_uc010mhz.2_Missense_Mutation_p.E1153D|MPDZ_uc011lmn.1_Missense_Mutation_p.E1153D|MPDZ_uc003zlb.3_Missense_Mutation_p.E1153D	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1153	PDZ 7.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		CTCTCCAGAGTTCCACCCTAA	0.284			NA											8	59					0	0	0.00308	0	0
CER1	9350	broad.mit.edu	37	9	14720334	14720334	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:14720334G>T	uc003zlj.2	-	2	603	c.558C>A	c.(556-558)TGC>TGA	p.C186*		NM_005454	NP_005445	O95813	CER1_HUMAN	cerberus 1 precursor	186	CTCK.				BMP signaling pathway	extracellular space	cytokine activity				0				GBM - Glioblastoma multiforme(50;3.16e-06)		ATTTCCCAAAGCAAAGGTTGT	0.438			NA											11	58					1.08611e-07	1.42471e-07	0.000978	1	0
HAUS6	54801	broad.mit.edu	37	9	19078172	19078172	+	Splice_Site	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:19078172A>C	uc003znk.2	-	10	1444	c.1191_splice	c.e10+1	p.P397_splice	HAUS6_uc011lmz.1_Splice_Site_p.P117_splice|HAUS6_uc003znl.1_Splice_Site_p.P261_splice|HAUS6_uc003znm.1_Splice_Site_p.P152_splice	NM_017645	NP_060115	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6						cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				ovary(2)	2						AACATTACTTACTGGAGTCCA	0.303			NA											27	57					0	0	0.007291	0	0
DENND4C	55667	broad.mit.edu	37	9	19352178	19352178	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:19352178G>T	uc003znq.2	+	20	3781	c.3748G>T	c.(3748-3750)GAG>TAG	p.E1250*	DENND4C_uc011lnc.1_Nonsense_Mutation_p.E580*|DENND4C_uc011lnd.1_Nonsense_Mutation_p.E538*|DENND4C_uc003znr.2_Nonsense_Mutation_p.E538*|DENND4C_uc003zns.2_Nonsense_Mutation_p.E432*|DENND4C_uc003znt.2_Nonsense_Mutation_p.E432*	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	1250						integral to membrane				ovary(1)|skin(1)	2						TTGTGCAATGGAGGTAAAAGT	0.269			NA											18	44					1.67942e-08	2.29485e-08	0.006122	1	0
KIAA1797	54914	broad.mit.edu	37	9	20907241	20907241	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:20907241G>T	uc003zog.1	+	24	3081	c.2718G>T	c.(2716-2718)CAG>CAT	p.Q906H	KIAA1797_uc003zoh.1_Missense_Mutation_p.Q342H	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	906						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		CCATTTTACAGGTAATGAAAC	0.348			NA											59	184					4.13886e-29	7.61511e-29	0.00361	1	0
KIAA1797	54914	broad.mit.edu	37	9	20953055	20953055	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:20953055G>C	uc003zog.1	+	37	4486	c.4123G>C	c.(4123-4125)GGA>CGA	p.G1375R	KIAA1797_uc003zoh.1_Missense_Mutation_p.G811R	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	1375						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		CATTACAGGAGGAAAAAAAGG	0.363			NA											9	45					0	0	0.008291	0	0
KIAA1797	54914	broad.mit.edu	37	9	20986465	20986465	+	Splice_Site	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:20986465G>T	uc003zog.1	+	42	5269	c.4906_splice	c.e42+1	p.G1636_splice	KIAA1797_uc003zoh.1_Splice_Site_p.G1072_splice	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914							integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		GCCAATACGGGTGAGGACACC	0.478			NA											4	20					0.00909568	0.00983662	0.009096	1	0
IFNA10	3446	broad.mit.edu	37	9	21206650	21206650	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:21206650T>A	uc003zoq.1	-	1	493	c.447A>T	c.(445-447)AGA>AGT	p.R149S	IFNA14_uc003zoo.1_Intron	NM_002171	NP_002162	P01566	IFN10_HUMAN	interferon, alpha 10 precursor	149					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.17)		AAAGAGTGATTCTTTGGAAGT	0.458			NA											37	496					0	0	0.007835	0	0
IFNA8	3445	broad.mit.edu	37	9	21409265	21409265	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:21409265C>A	uc003zpc.1	+	1	120	c.90C>A	c.(88-90)CAC>CAA	p.H30Q		NM_002170	NP_002161	P32881	IFNA8_HUMAN	interferon, alpha 8 precursor	30					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0174)		CTCAGACTCACAGCCTGGGTA	0.502			NA											12	189					0.000978159	0.00108999	0.000978	1	0
TAF1L	138474	broad.mit.edu	37	9	32634689	32634689	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:32634689C>A	uc003zrg.1	-	1	979	c.889G>T	c.(889-891)GTG>TTG	p.V297L	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	297					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GAGCATTCCACCTCCTGGATC	0.498			NA											56	149					3.37043e-27	6.11362e-27	0.00361	1	0
UBAP1	51271	broad.mit.edu	37	9	34249796	34249796	+	Nonsense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:34249796C>G	uc003ztx.2	+	5	1338	c.1103C>G	c.(1102-1104)TCA>TGA	p.S368*	UBAP1_uc010mka.1_Nonsense_Mutation_p.S404*|UBAP1_uc003zty.2_Nonsense_Mutation_p.S368*|UBAP1_uc011loi.1_Nonsense_Mutation_p.S404*|UBAP1_uc011loj.1_Nonsense_Mutation_p.S432*|KIF24_uc010mkb.2_Intron|UBAP1_uc003ztz.2_Nonsense_Mutation_p.S368*	NM_016525	NP_057609	Q9NZ09	UBAP1_HUMAN	ubiquitin associated protein 1	368						cytoplasm					0			LUSC - Lung squamous cell carcinoma(29;0.00272)			CCTAATTTCTCAGTGTCACAA	0.557	NSCLC(109;1074 1634 14978 20375 39620)		NA											13	161					0	0	0.001368	0	0
ENHO	375704	broad.mit.edu	37	9	34521483	34521483	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:34521483T>C	uc003zun.1	-	2	635	c.211A>G	c.(211-213)AGC>GGC	p.S71G	ENHO_uc003zuo.2_Intron	NM_198573	NP_940975	Q6UWT2	ENHO_HUMAN	adropin precursor	71						extracellular region					0						AGCAGGTAGCTGCCTTCATGG	0.617			NA											21	77					0	0	0.003954	0	0
RECK	8434	broad.mit.edu	37	9	36117030	36117030	+	Silent	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:36117030A>T	uc003zyv.2	+	17	2195	c.2109A>T	c.(2107-2109)GGA>GGT	p.G703G	RECK_uc003zyw.2_Silent_p.G575G|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	703	Kazal-like 2.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			ATAAATTTGGATGTAGCCAGT	0.493			NA											34	125					0	0	0.004878	0	0
PAX5	5079	broad.mit.edu	37	9	36882089	36882089	+	Silent	SNP	C	C	A	rs145283614		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:36882089C>A	uc003zzo.1	-	8	1372	c.924G>T	c.(922-924)GCG>GCT	p.A308A	PAX5_uc011lpt.1_Silent_p.A104A|PAX5_uc011lpu.1_Intron|PAX5_uc011lpv.1_Intron|PAX5_uc011lpw.1_Intron|PAX5_uc011lpx.1_Intron|PAX5_uc011lpy.1_Intron|PAX5_uc010mls.1_Intron|PAX5_uc011lpz.1_Silent_p.A265A|PAX5_uc011lqa.1_Silent_p.A200A|PAX5_uc010mlq.1_RNA|PAX5_uc011lqb.1_RNA|PAX5_uc010mlo.1_Intron|PAX5_uc010mlp.1_Silent_p.A308A|PAX5_uc011lqc.1_Silent_p.A265A|PAX5_uc010mlr.1_Intron	NM_016734	NP_057953	Q02548	PAX5_HUMAN	paired box 5	308					cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(22)	PAX5/JAK2(18)	haematopoietic_and_lymphoid_tissue(142)|lung(3)|central_nervous_system(2)	147		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		GGGTCGTGCTCGCCAAGTCAC	0.622			NA	T|Mis|D|F|S	IGH@|ETV6|PML|FOXP1|ZNF521|ELN	NHL|ALL|B-ALL								7	26					0.000157383	0.000180738	0.00308	1	0
CNTNAP3	79937	broad.mit.edu	37	9	39178249	39178249	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:39178249T>G	uc004abi.2	-	5	886	c.647A>C	c.(646-648)CAG>CCG	p.Q216P	CNTNAP3_uc004abj.2_Missense_Mutation_p.Q216P|CNTNAP3_uc011lqr.1_RNA|CNTNAP3_uc004abk.1_Missense_Mutation_p.Q216P|CNTNAP3_uc011lqs.1_Missense_Mutation_p.Q216P|CNTNAP3_uc004abl.1_Missense_Mutation_p.Q128P	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	cell recognition molecule CASPR3 precursor	216	Extracellular (Potential).|Laminin G-like 1.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TCCATTGCTCTGCATGGCTTT	0.323			NA											14	206					0	0	0.001855	0	0
FAM75A3	727830	broad.mit.edu	37	9	40702662	40702662	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:40702662C>A	uc010mmj.2	+	4	348	c.319C>A	c.(319-321)CCA>ACA	p.P107T		NM_001083124	NP_001076593	Q5VYP0	F75A3_HUMAN	hypothetical protein LOC727830	107						integral to membrane				ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CCTCCTGGGGCCACACCTTGA	0.667			NA											13	83					3.41278e-10	4.95352e-10	0.00499	1	0
FAM75A3	727830	broad.mit.edu	37	9	40702747	40702747	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:40702747C>A	uc010mmj.2	+	4	433	c.404C>A	c.(403-405)TCC>TAC	p.S135Y		NM_001083124	NP_001076593	Q5VYP0	F75A3_HUMAN	hypothetical protein LOC727830	135	Pro-rich.					integral to membrane				ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GATGGAGCCTCCCAGTCCTCT	0.597			NA											46	423					1.14385e-22	2.01318e-22	0.00361	1	0
FAM75A3	727830	broad.mit.edu	37	9	40704246	40704246	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:40704246C>A	uc010mmj.2	+	4	1932	c.1903C>A	c.(1903-1905)CAG>AAG	p.Q635K		NM_001083124	NP_001076593	Q5VYP0	F75A3_HUMAN	hypothetical protein LOC727830	635						integral to membrane				ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		AGGGACAAGTCAGGCCAAGGG	0.542			NA											16	147					2.4624e-09	3.4631e-09	0.008871	1	0
FAM75A3	727830	broad.mit.edu	37	9	40705716	40705716	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:40705716C>A	uc010mmj.2	+	4	3402	c.3373C>A	c.(3373-3375)CTT>ATT	p.L1125I		NM_001083124	NP_001076593	Q5VYP0	F75A3_HUMAN	hypothetical protein LOC727830	1125						integral to membrane				ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TGAAGAAAGGCTTGAAGGATT	0.468			NA											51	392					2.12129e-23	3.77226e-23	0.00361	1	0
FAM75A3	727830	broad.mit.edu	37	9	40705718	40705718	+	Silent	SNP	T	T	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:40705718T>G	uc010mmj.2	+	4	3404	c.3375T>G	c.(3373-3375)CTT>CTG	p.L1125L		NM_001083124	NP_001076593	Q5VYP0	F75A3_HUMAN	hypothetical protein LOC727830	1125						integral to membrane				ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		AAGAAAGGCTTGAAGGATTGA	0.468			NA											49	376					0	0	0.00361	0	0
ZNF658	26149	broad.mit.edu	37	9	40774548	40774548	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:40774548A>G	uc004abs.2	-	5	879	c.727T>C	c.(727-729)TGT>CGT	p.C243R	ZNF658_uc010mmm.1_Missense_Mutation_p.C243R|ZNF658_uc010mmn.1_Missense_Mutation_p.C243R	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TCATCCTTACAGGACTTTTCT	0.333			NA											6	103					0	0	0.001984	0	0
Unknown	0	broad.mit.edu	37	9	69440291	69440291	+	Silent	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:69440291A>G	uc010mnx.1	+	3	544	c.375A>G	c.(373-375)TTA>TTG	p.L125L		NM_001098806	NP_001092276			coiled-coil domain containing 29												NA						TAGAAAAATTAGAAGAAATCC	0.279			NA											9	88					0	0	0.004482	0	0
GDA	9615	broad.mit.edu	37	9	74840612	74840612	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:74840612G>T	uc004aiq.2	+	8	917	c.734G>T	c.(733-735)CGT>CTT	p.R245L	GDA_uc011lse.1_Missense_Mutation_p.R171L|GDA_uc011lsf.1_Missense_Mutation_p.R171L|GDA_uc004air.2_Missense_Mutation_p.R245L|GDA_uc010mow.1_RNA|GDA_uc004ais.2_Missense_Mutation_p.R167L|GDA_uc004ait.1_Missense_Mutation_p.R171L	NM_004293	NP_004284	Q9Y2T3	GUAD_HUMAN	guanine deaminase	245					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		AGTGAAAATCGTGATGAAGTT	0.279			NA											19	135					2.89027e-11	4.29634e-11	0.002299	1	0
TRPM6	140803	broad.mit.edu	37	9	77411735	77411735	+	Silent	SNP	A	A	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:77411735A>T	uc004ajl.1	-	18	2551	c.2313T>A	c.(2311-2313)GTT>GTA	p.V771V	TRPM6_uc004ajk.1_Silent_p.V766V|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajm.1_Silent_p.V149V	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	771	Extracellular (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GGGACTGGGGAACATGTGACA	0.368			NA											20	101					0	0	0.008871	0	0
TRPM6	140803	broad.mit.edu	37	9	77442833	77442833	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:77442833G>T	uc004ajl.1	-	7	940	c.702C>A	c.(700-702)CCC>CCA	p.P234P	TRPM6_uc004ajk.1_Silent_p.P229P|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Silent_p.P234P|TRPM6_uc010mpd.1_Silent_p.P234P|TRPM6_uc010mpe.1_Silent_p.P234P|TRPM6_uc004ajn.1_Silent_p.P234P	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	234	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GCTTGCTGAGGGGGTTATCCA	0.532			NA											10	116					1.58986e-06	2.00195e-06	0.008291	1	0
GCNT1	2650	broad.mit.edu	37	9	79117415	79117415	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:79117415T>A	uc010mpf.2	+	3	459	c.118T>A	c.(118-120)TTT>ATT	p.F40I	GCNT1_uc010mpg.2_Missense_Mutation_p.F40I|GCNT1_uc010mph.2_Missense_Mutation_p.F40I|GCNT1_uc004akf.3_Missense_Mutation_p.F40I|GCNT1_uc010mpi.2_Missense_Mutation_p.F40I|GCNT1_uc004akh.3_Missense_Mutation_p.F40I	NM_001490	NP_001481	Q02742	GCNT1_HUMAN	beta-1,3-galactosyl-O-glycosyl-glycoprotein	40	Lumenal (Potential).|Stem region (By similarity).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity				0						AAAGCCTGAATTTGTAAGTGT	0.378			NA											12	95					0	0	0.001368	0	0
PRUNE2	158471	broad.mit.edu	37	9	79325636	79325636	+	Silent	SNP	T	T	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:79325636T>G	uc010mpk.2	-	8	1678	c.1554A>C	c.(1552-1554)GCA>GCC	p.A518A		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	518					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						AGAAGTCATCTGCTGGGGAGT	0.522			NA											10	25					0	0	0.008291	0	0
FLJ46321	389763	broad.mit.edu	37	9	84609611	84609611	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:84609611C>G	uc004amn.2	+	4	4273	c.4226C>G	c.(4225-4227)ACT>AGT	p.T1409S		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1409						integral to membrane					0						AGGAAAGACACTAGGGAGTTC	0.493			NA											3	22					0	0	0.009096	0	0
FAM75C1	441452	broad.mit.edu	37	9	90536114	90536114	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:90536114T>C	uc010mqi.2	+	4	1321	c.1292T>C	c.(1291-1293)GTC>GCC	p.V431A	FAM75C1_uc004apq.3_Missense_Mutation_p.V414A	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						GTCTTTAGTGTCTCCACTCCT	0.493			NA											39	200					0	0	0.006999	0	0
SEMA4D	10507	broad.mit.edu	37	9	91994133	91994133	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:91994133G>C	uc004aqo.1	-	18	2647	c.2075C>G	c.(2074-2076)TCC>TGC	p.S692C	SEMA4D_uc011ltm.1_Intron|SEMA4D_uc011ltn.1_Intron|SEMA4D_uc011lto.1_Intron|SEMA4D_uc004aqp.1_Missense_Mutation_p.S690C	NM_006378	NP_006369	Q92854	SEM4D_HUMAN	semaphorin 4D isoform 1	692	Extracellular (Potential).				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2						GATGGCCCCGGAGGAGGTGGC	0.602			NA											4	73					0	0	0.009096	0	0
ROR2	4920	broad.mit.edu	37	9	94493208	94493208	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:94493208A>C	uc004arj.1	-	7	1366	c.1167T>G	c.(1165-1167)TGT>TGG	p.C389W	ROR2_uc004ari.1_Missense_Mutation_p.C249W|ROR2_uc004ark.2_Intron	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	389	Extracellular (Potential).|Kringle.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						AGGGTACGTCACACAGTTCCA	0.527			NA											13	55					0	0	0.001855	0	0
CENPP	401541	broad.mit.edu	37	9	95375392	95375392	+	Silent	SNP	A	A	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:95375392A>G	uc004arz.2	+	8	1368	c.828A>G	c.(826-828)GAA>GAG	p.E276E	CENPP_uc010mqx.2_Silent_p.E164E|CENPP_uc004asj.2_Silent_p.E103E	NM_001012267	NP_001012267	Q6IPU0	CENPP_HUMAN	centromere protein P	276					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	chromosome, centromeric region|cytosol|nucleoplasm				ovary(2)	2						CTGCTCTGGAAAGCCTGATAA	0.473			NA											10	122					0	0	0.000978	0	0
FBP2	8789	broad.mit.edu	37	9	97325681	97325681	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:97325681G>T	uc004auv.2	-	6	835	c.768C>A	c.(766-768)ACC>ACA	p.T256T	uc004aus.1_Intron|uc004aut.1_Intron|uc004auu.2_Intron	NM_003837	NP_003828	O00757	F16P2_HUMAN	fructose-1,6-bisphosphatase 2	256					fructose metabolic process|gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|metal ion binding				0		Acute lymphoblastic leukemia(62;0.136)				CATAGACCAGGGTGCGGTGCA	0.572			NA											7	64					2.0095e-06	2.51391e-06	0.001984	1	0
HSD17B3	3293	broad.mit.edu	37	9	99006653	99006653	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:99006653C>T	uc004awa.1	-	9	678	c.630G>A	c.(628-630)AAG>AAA	p.K210K	HSD17B3_uc010msc.1_Silent_p.K210K	NM_000197	NP_000188	P37058	DHB3_HUMAN	estradiol 17 beta-dehydrogenase 3	210					androgen biosynthetic process|male genitalia development	endoplasmic reticulum membrane|microsome	binding|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity				0		Acute lymphoblastic leukemia(62;0.0171)|all_hematologic(171;0.214)			NADH(DB00157)	CTTGCAGGGCCTTGGAAAATG	0.552			NA											12	110					0	0	0.001368	0	0
NR4A3	8013	broad.mit.edu	37	9	102607124	102607124	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:102607124C>A	uc004baf.1	+	6	2177	c.1448C>A	c.(1447-1449)TCC>TAC	p.S483Y	NR4A3_uc004bag.1_Missense_Mutation_p.S483Y|NR4A3_uc004bai.2_Missense_Mutation_p.S494Y	NM_006981	NP_008912	Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	483	Ligand-binding (Potential).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		EWSR1/NR4A3(140)|TAF15/NR4A3(33)	bone(173)	173		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				CTCAGACTTTCCATCAGGTAA	0.393			NA	T	EWSR1	extraskeletal myxoid chondrosarcoma								10	40					4.68919e-08	6.2631e-08	0.008291	1	0
TEX10	54881	broad.mit.edu	37	9	103084051	103084051	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:103084051G>A	uc004bas.2	-	10	2197	c.1982C>T	c.(1981-1983)TCA>TTA	p.S661L	TEX10_uc011lvf.1_Missense_Mutation_p.S500L|TEX10_uc011lvg.1_Missense_Mutation_p.S664L	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	661						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		AGAAAATGATGATCTATAAAA	0.363			NA											6	83					0	0	0.00308	0	0
RNF20	56254	broad.mit.edu	37	9	104319843	104319843	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:104319843G>C	uc004bbn.2	+	16	2437	c.2347G>C	c.(2347-2349)GAG>CAG	p.E783Q		NM_019592	NP_062538	Q5VTR2	BRE1A_HUMAN	ring finger protein 20	783	Potential.				histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|breast(1)|kidney(1)|skin(1)	8		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		AGAGAAGGAGGAGCTGGCAGA	0.413			NA											5	41					0	0	0.000602	0	0
OR13C8	138802	broad.mit.edu	37	9	107331853	107331853	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:107331853C>T	uc011lvo.1	+	1	405	c.405C>T	c.(403-405)ATC>ATT	p.I135I		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ACCCTGTCATCATGAGCAAGG	0.537			NA											15	62					0	0	0.003163	0	0
OR13C5	138799	broad.mit.edu	37	9	107361006	107361006	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:107361006G>T	uc011lvp.1	-	1	689	c.689C>A	c.(688-690)TCT>TAT	p.S230Y		NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CCCCTCCGAAGAGCTAATTTT	0.423			NA											30	85					2.61193e-14	4.15106e-14	0.009535	1	0
FKTN	2218	broad.mit.edu	37	9	108363572	108363572	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:108363572C>G	uc004bcr.2	+	5	528	c.312C>G	c.(310-312)TTC>TTG	p.F104L	FKTN_uc011lvx.1_Missense_Mutation_p.F104L|FKTN_uc004bcs.2_Missense_Mutation_p.F104L|FKTN_uc011lvy.1_Missense_Mutation_p.F104L|FKTN_uc010mtm.2_5'UTR	NM_001079802	NP_001073270	O75072	FKTN_HUMAN	fukutin	104	Lumenal (Potential).				muscle organ development|negative regulation of cell proliferation|negative regulation of JNK cascade|nervous system development|regulation of protein glycosylation	cis-Golgi network|endoplasmic reticulum|extracellular space|Golgi membrane|integral to membrane|nucleus	transferase activity			breast(2)|ovary(1)	3						GCAAGTTTTTCTGTGTTCCAA	0.353			NA											6	72					0	0	0.001984	0	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112705122	112705122	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:112705122G>T	uc004bei.2	+	7	845	c.653G>T	c.(652-654)GGC>GTC	p.G218V	PALM2_uc004bef.2_Missense_Mutation_p.G220V|PALM2_uc004beg.2_Missense_Mutation_p.G186V|PALM2_uc004beh.3_Missense_Mutation_p.G218V|PALM2-AKAP2_uc004bek.3_Intron|PALM2-AKAP2_uc004bej.3_Intron|PALM2-AKAP2_uc004bel.1_Intron	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						CGCTCAGGAGGCACCGTAGTA	0.468			NA											9	38					3.09899e-07	3.99367e-07	0.004482	1	0
SVEP1	79987	broad.mit.edu	37	9	113132270	113132270	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:113132270C>G	uc010mtz.2	-	47	10964	c.10627G>C	c.(10627-10629)GGT>CGT	p.G3543R	SVEP1_uc010mty.2_Missense_Mutation_p.G1469R	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	3543	EGF-like 9.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						CATTTTCCACCATTTAAGCAG	0.378			NA											3	32					0	0	0.004672	0	0
SVEP1	79987	broad.mit.edu	37	9	113169032	113169032	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:113169032C>A	uc010mtz.2	-	38	9185	c.8848G>T	c.(8848-8850)GGA>TGA	p.G2950*	SVEP1_uc010mty.2_Nonsense_Mutation_p.G876*	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2950	Sushi 26.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TCAGGAGGTCCACAGTTGACT	0.483			NA											36	209					2.19358e-23	3.89183e-23	0.005524	1	0
PTGR1	22949	broad.mit.edu	37	9	114359635	114359635	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:114359635T>G	uc004bfh.2	-	2	171	c.68A>C	c.(67-69)GAG>GCG	p.E23A	PTGR1_uc011lwr.1_Missense_Mutation_p.E23A|PTGR1_uc004bfi.3_Missense_Mutation_p.E23A|PTGR1_uc004bfj.3_5'UTR|PTGR1_uc010mue.2_Missense_Mutation_p.E23A	NM_012212	NP_036344	Q14914	PTGR1_HUMAN	prostaglandin reductase 1 isoform 1	23					leukotriene metabolic process	cytoplasm	15-oxoprostaglandin 13-oxidase activity|2-alkenal reductase activity|alcohol dehydrogenase (NAD) activity|zinc ion binding				0						TGTCTTCAACTCAAAGTCACT	0.358	Ovarian(200;132 2151 7551 19220 46064)		NA											5	48					0	0	0.001168	0	0
SNX30	401548	broad.mit.edu	37	9	115600941	115600941	+	Silent	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:115600941G>C	uc004bgj.3	+	6	1126	c.978G>C	c.(976-978)GTG>GTC	p.V326V	SNX30_uc004bgi.3_Silent_p.V8V	NM_001012994	NP_001013012	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	326					cell communication|protein transport	cytoplasm	phosphatidylinositol binding				0						TCCTACCTGTGCTCAGGGAAT	0.438			NA											17	100					0	0	0.00499	0	0
ZFP37	7539	broad.mit.edu	37	9	115806314	115806314	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:115806314C>A	uc004bgm.1	-	4	612	c.584G>T	c.(583-585)AGA>ATA	p.R195I	ZFP37_uc011lwz.1_Missense_Mutation_p.R210I|ZFP37_uc011lxa.1_Missense_Mutation_p.R196I	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	195						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TACACAGTTTCTTGAGTGATC	0.323			NA											27	144					6.36457e-07	8.12723e-07	0.003954	1	0
COL27A1	85301	broad.mit.edu	37	9	116931198	116931198	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:116931198C>T	uc011lxl.1	+	3	1363	c.1363C>T	c.(1363-1365)CCC>TCC	p.P455S	COL27A1_uc004bii.2_RNA|COL27A1_uc010mvd.1_Missense_Mutation_p.P305S	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	455	Pro-rich.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						AAAACCCATTCCCACACTAGC	0.612			NA											7	161					0	0	0.004482	0	0
COL27A1	85301	broad.mit.edu	37	9	116956729	116956729	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:116956729G>T	uc011lxl.1	+	6	2062	c.2062G>T	c.(2062-2064)GGG>TGG	p.G688W	COL27A1_uc004bii.2_Intron|COL27A1_uc010mvd.1_Intron	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	688	Collagen-like 2.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						GGCCCACGATGGGGCAAAGGT	0.527			NA											27	160					5.61819e-17	9.38396e-17	0.005443	1	0
TNC	3371	broad.mit.edu	37	9	117838396	117838396	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:117838396C>T	uc004bjj.3	-	9	3227	c.2865G>A	c.(2863-2865)CTG>CTA	p.L955L	TNC_uc010mvf.2_Silent_p.L955L	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	955	Fibronectin type-III 4.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						TTCCCGGCCTCAGACCTAAGG	0.493			NA											21	96					0	0	0.001882	0	0
CCBL1	883	broad.mit.edu	37	9	131597919	131597919	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:131597919C>T	uc004bwh.2	-	10	1068	c.883G>A	c.(883-885)GAG>AAG	p.E295K	CCBL1_uc004bwf.2_Missense_Mutation_p.E329K|CCBL1_uc004bwg.2_RNA|CCBL1_uc010myn.2_Missense_Mutation_p.E295K|CCBL1_uc004bwj.2_Missense_Mutation_p.E245K|CCBL1_uc011mbl.1_Missense_Mutation_p.E389K|CCBL1_uc004bwi.2_RNA|CCBL1_uc010myo.2_Missense_Mutation_p.E252K	NM_004059	NP_004050	Q16773	KAT1_HUMAN	kynurenine aminotransferase I isoform a	295					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)	AGCAGCTGCTCCCGTTCAAAG	0.602			NA											3	24					0	0	0.004672	0	0
LRRC8A	56262	broad.mit.edu	37	9	131670448	131670448	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:131670448C>G	uc004bwl.3	+	3	1259	c.1005C>G	c.(1003-1005)ATC>ATG	p.I335M	LRRC8A_uc010myp.2_Missense_Mutation_p.I335M|LRRC8A_uc010myq.2_Missense_Mutation_p.I335M	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	335	Helical; (Potential).				pre-B cell differentiation	integral to membrane					0						ACGGCCTCATCTGCATGTATA	0.572			NA											6	104					0	0	0.001168	0	0
LAMC3	10319	broad.mit.edu	37	9	133962940	133962940	+	Silent	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:133962940G>C	uc004caa.1	+	26	4406	c.4308G>C	c.(4306-4308)ACG>ACC	p.T1436T	LAMC3_uc010mze.1_Silent_p.T124T	NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	1436	Domain II and I.|Potential.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CGCAAGCCACGCTCCAACAGG	0.657			NA											16	44					0	0	0.003163	0	0
NUP214	8021	broad.mit.edu	37	9	134039265	134039265	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:134039265G>T	uc004cag.2	+	20	2843	c.2732G>T	c.(2731-2733)AGT>ATT	p.S911I	NUP214_uc004cah.2_Missense_Mutation_p.S901I|NUP214_uc004cai.2_Missense_Mutation_p.S341I|NUP214_uc004caf.1_Missense_Mutation_p.S900I|NUP214_uc010mzf.2_Missense_Mutation_p.S209I	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	911	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		AGTTTTGACAGTGACCTGGAA	0.438	Pancreas(4;24 48 25510 30394 32571)		NA	T	DEK|SET|ABL1	AML|T-ALL								45	182					1.81118e-26	3.27758e-26	0.00361	1	0
SETX	23064	broad.mit.edu	37	9	135204107	135204107	+	Nonsense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:135204107T>A	uc004cbk.2	-	10	3061	c.2878A>T	c.(2878-2880)AGA>TGA	p.R960*	SETX_uc004cbj.2_Nonsense_Mutation_p.R579*|SETX_uc010mzt.2_Nonsense_Mutation_p.R579*	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	960					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TGAAGGTCTCTGTCTATCTGA	0.413			NA											8	93					0	0	0.00308	0	0
C9orf171	389799	broad.mit.edu	37	9	135447814	135447814	+	Missense_Mutation	SNP	C	C	G	rs141309620	byFrequency	TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:135447814C>G	uc004cbn.2	+	7	928	c.880C>G	c.(880-882)CGC>GGC	p.R294G	C9orf171_uc004cbo.2_Missense_Mutation_p.R258G	NM_207417	NP_997300	Q6ZQR2	CI171_HUMAN	hypothetical protein LOC389799	294										ovary(4)|large_intestine(1)	5						GGAGGCCGATCGCCAGAGAGC	0.627			NA											4	64					0	0	0.001168	0	0
COL5A1	1289	broad.mit.edu	37	9	137703228	137703228	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:137703228C>T	uc004cfe.2	+	45	3954	c.3572C>T	c.(3571-3573)CCA>CTA	p.P1191L		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1191	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		ATCGGACAGCCAGGCCCCTCT	0.592			NA									OREG0019605	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	162					0	0	0.009535	0	0
SOHLH1	402381	broad.mit.edu	37	9	138589372	138589372	+	Silent	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:138589372C>A	uc004cgl.2	-	4	508	c.447G>T	c.(445-447)ACG>ACT	p.T149T	SOHLH1_uc010nbe.2_Silent_p.T149T	NM_001012415	NP_001012415	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic	149					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)	2		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		TGGACGCTCCCGTCCCAGGGT	0.602			NA											7	25					0.000157383	0.000180738	0.00308	1	0
ABCA2	20	broad.mit.edu	37	9	139905706	139905706	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:139905706T>A	uc011mem.1	-	37	6000	c.5852A>T	c.(5851-5853)TAC>TTC	p.Y1951F	ABCA2_uc011mel.1_Missense_Mutation_p.Y1952F|ABCA2_uc004ckl.1_Missense_Mutation_p.Y1882F|ABCA2_uc004ckm.1_Missense_Mutation_p.Y1982F	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1951					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GCCCAGGTTGTAGTTGGGGAA	0.617			NA											15	38					0	0	0.00245	0	0
TUBBP5	643224	broad.mit.edu	37	9	141071340	141071340	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:141071340G>A	uc004com.2	+	4	1004	c.743G>A	c.(742-744)CGC>CAC	p.R248H	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						TTCCAGGGTCGCATGCCCATG	0.542			NA											9	120					0	0	0.001368	0	0
MXRA5	25878	broad.mit.edu	37	X	3235987	3235987	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:3235987G>T	uc004crg.3	-	6	5892	c.5735C>A	c.(5734-5736)ACC>AAC	p.T1912N		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1912	Ig-like C2-type 3.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TATCACTAAGGTACCGTTCTT	0.498			NA											13	16					1.5842e-08	2.18022e-08	0.001855	1	0
AMELX	265	broad.mit.edu	37	X	11316996	11316996	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:11316996T>A	uc004cut.2	+	5	541	c.473T>A	c.(472-474)CTG>CAG	p.L158Q	ARHGAP6_uc004cup.1_Intron|ARHGAP6_uc004cuo.1_Intron|ARHGAP6_uc004cur.1_Intron|ARHGAP6_uc004cun.1_Intron|ARHGAP6_uc011mif.1_Intron|AMELX_uc004cus.2_Missense_Mutation_p.L172Q|AMELX_uc004cuu.2_Missense_Mutation_p.L142Q	NM_001142	NP_001133	Q99217	AMELX_HUMAN	amelogenin (X chromosome) isoform 1 precursor	158					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel				0						CAGCCACCTCTGCCTCCGATG	0.642			NA											9	3					0	0	0.004482	0	0
KLHL34	257240	broad.mit.edu	37	X	21674113	21674113	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:21674113G>A	uc004czz.1	-	1	2336	c.1794C>T	c.(1792-1794)GAC>GAT	p.D598D		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	598	Kelch 6.									ovary(1)	1						AACGGTCCAGGTCGAGGTCGT	0.711			NA											5	13					0	0	0.000602	0	0
DDX53	168400	broad.mit.edu	37	X	23020012	23020012	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:23020012G>T	uc004daj.2	+	1	1926	c.1838G>T	c.(1837-1839)AGA>ATA	p.R613I		NM_182699	NP_874358	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	613						nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			large_intestine(1)|ovary(1)|kidney(1)	3						AAGAGGCACAGAGAAACACGA	0.383			NA											11	20					6.40141e-05	7.49101e-05	0.000978	1	0
FAM48B2	170067	broad.mit.edu	37	X	24330937	24330937	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:24330937G>T	uc011mjw.1	-	1	496	c.496C>A	c.(496-498)CTT>ATT	p.L166I		NM_001136233	NP_001129705	P0C7V6	F48B2_HUMAN	family with sequence similarity 48, member B2	166											0						GGACGTAGAAGAATATGCCTG	0.453			NA											40	75					2.66277e-13	4.14627e-13	0.006999	1	0
NR0B1	190	broad.mit.edu	37	X	30327199	30327199	+	Silent	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:30327199C>G	uc004dcf.3	-	1	297	c.282G>C	c.(280-282)CCG>CCC	p.P94P		NM_000475	NP_000466	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	94	4 X 67 AA tandem repeats.|2.				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			ovary(1)|lung(1)	2					Dexamethasone(DB01234)|Tretinoin(DB00755)	CGGGCGCCTTCGGTGCCGCGT	0.687			NA											3	31					0	0	0.004672	0	0
GK	2710	broad.mit.edu	37	X	30726207	30726207	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:30726207G>A	uc004dch.3	+	13	1110	c.931G>A	c.(931-933)GCT>ACT	p.A311T	GK_uc010ngj.2_Missense_Mutation_p.A305T|GK_uc004dci.3_Missense_Mutation_p.A305T|GK_uc011mjz.1_Missense_Mutation_p.A106T|GK_uc011mka.1_Missense_Mutation_p.A148T|GK_uc010ngk.2_Missense_Mutation_p.A100T	NM_203391	NP_976325	P32189	GLPK_HUMAN	glycerol kinase isoform a	311					glycerol-3-phosphate metabolic process|triglyceride biosynthetic process	cytosol|mitochondrial outer membrane	ATP binding|glycerol kinase activity			central_nervous_system(1)	1						CACCACAGTGGCTTACAAACT	0.303			NA											6	34					0	0	0.001984	0	0
FAM47C	442444	broad.mit.edu	37	X	37028486	37028486	+	Missense_Mutation	SNP	C	C	A	rs142735792	byFrequency	TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:37028486C>A	uc004ddl.1	+	1	2017	c.2003C>A	c.(2002-2004)CCG>CAG	p.P668Q		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	668										ovary(3)	3						AGTCTCCCCCCGGAGCCCCCC	0.642			NA											14	20					1.02788e-11	1.54584e-11	0.00499	1	0
SSX7	280658	broad.mit.edu	37	X	52677375	52677375	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:52677375G>A	uc004dqx.1	-	6	561	c.402C>T	c.(400-402)AAC>AAT	p.N134N		NM_173358	NP_775494	Q7RTT5	SSX7_HUMAN	synovial sarcoma, X breakpoint 7	134					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			skin(1)	1	Ovarian(276;0.236)					GTTTCCCATCGTTCTGTGAGC	0.468			NA											76	136					0	0	0.00361	0	0
TRO	7216	broad.mit.edu	37	X	54956381	54956381	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:54956381C>A	uc004dtq.2	+	12	3331	c.3224C>A	c.(3223-3225)ACC>AAC	p.T1075N	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_Intron|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Missense_Mutation_p.T606N|TRO_uc004dtw.2_Missense_Mutation_p.T678N|TRO_uc004dtx.2_Missense_Mutation_p.T458N	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	1075	62 X 10 AA approximate tandem repeats.|27; approximate.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						GCCGTCAGCACCAGTGCCAGC	0.577			NA											8	13					0.000157383	0.000180738	0.00308	1	0
FOXR2	139628	broad.mit.edu	37	X	55651049	55651049	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:55651049C>A	uc004duo.2	+	1	1217	c.905C>A	c.(904-906)CCA>CAA	p.P302Q		NM_198451	NP_940853	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	302					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(2)|central_nervous_system(1)	3						ATGAGTCAGCCAGAGTTGTTG	0.483			NA											14	26					0.000219431	0.000251245	0.00245	1	0
STARD8	9754	broad.mit.edu	37	X	67937280	67937280	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:67937280C>A	uc004dxa.2	+	5	656	c.284C>A	c.(283-285)CCA>CAA	p.P95Q	STARD8_uc004dxb.2_Missense_Mutation_p.P175Q|STARD8_uc004dxc.3_Missense_Mutation_p.P95Q	NM_014725	NP_055540	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain	95					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			breast(3)|ovary(2)|pancreas(1)	6						TTGCCCTTGCCAGGCCGTGCC	0.657			NA											8	13					0.00307968	0.0033804	0.00308	1	0
RLIM	51132	broad.mit.edu	37	X	73812542	73812542	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:73812542G>A	uc004ebu.2	-	5	898	c.608C>T	c.(607-609)CCA>CTA	p.P203L	RLIM_uc004ebw.2_Missense_Mutation_p.P203L	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	203					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TCTGGTAGGTGGGACCTCTGT	0.498	Esophageal Squamous(169;1899 1923 14997 18818 32118)		NA											43	79					0	0	0.00361	0	0
P2RY10	27334	broad.mit.edu	37	X	78216452	78216452	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:78216452G>C	uc004ede.2	+	4	804	c.435G>C	c.(433-435)AAG>AAC	p.K145N	P2RY10_uc004edf.2_Missense_Mutation_p.K145N	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	145	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						GAGACTGGAAGCGTAGGTACG	0.488			NA											19	58					0	0	0.008871	0	0
KLHL4	56062	broad.mit.edu	37	X	86773015	86773015	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:86773015G>T	uc004efb.2	+	1	301	c.119G>T	c.(118-120)GGA>GTA	p.G40V	KLHL4_uc004efa.2_Missense_Mutation_p.G40V	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	40						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CAGCAGGAAGGATATGAGCAT	0.488			NA											22	47					1.96292e-10	2.8626e-10	0.010504	1	0
CPXCR1	53336	broad.mit.edu	37	X	88008656	88008656	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:88008656C>T	uc004efd.3	+	3	500	c.241C>T	c.(241-243)CGA>TGA	p.R81*	CPXCR1_uc004efc.3_Nonsense_Mutation_p.R81*	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	81						intracellular	zinc ion binding			ovary(3)	3						AAAAGATCAACGAGAAGAAGA	0.458			NA											4	11					0	0	0.009096	0	0
PCDH11X	27328	broad.mit.edu	37	X	91131875	91131875	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:91131875G>T	uc004efk.1	+	2	1481	c.636G>T	c.(634-636)AAG>AAT	p.K212N	PCDH11X_uc004efl.1_Missense_Mutation_p.K212N|PCDH11X_uc004efo.1_Missense_Mutation_p.K212N|PCDH11X_uc010nmv.1_Missense_Mutation_p.K212N|PCDH11X_uc004efm.1_Missense_Mutation_p.K212N|PCDH11X_uc004efn.1_Missense_Mutation_p.K212N|PCDH11X_uc004efh.1_Missense_Mutation_p.K212N|PCDH11X_uc004efj.1_Missense_Mutation_p.K212N	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	212	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						GGGAAGAGAAGGATACCTACG	0.408	NSCLC(38;925 1092 2571 38200 45895)		NA											36	36					4.32679e-17	7.24267e-17	0.006999	1	0
DIAPH2	1730	broad.mit.edu	37	X	96328001	96328001	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:96328001A>C	uc004efu.3	+	18	2508	c.2112A>C	c.(2110-2112)AAA>AAC	p.K704N	DIAPH2_uc004eft.3_Missense_Mutation_p.K704N	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	704	FH2.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						AGAAAGTGAAAGAACTGAGAA	0.378			NA											3	21					0	0	0.000602	0	0
PRPS1	5631	broad.mit.edu	37	X	106890894	106890894	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:106890894G>T	uc004ene.3	+	6	968	c.763G>T	c.(763-765)GGT>TGT	p.G255C	PRPS1_uc010npg.2_Missense_Mutation_p.G222C|PRPS1_uc011msj.1_Missense_Mutation_p.G51C	NM_002764	NP_002755	P60891	PRPS1_HUMAN	phosphoribosyl pyrophosphate synthetase 1	255					5-phosphoribose 1-diphosphate biosynthetic process|hypoxanthine biosynthetic process|nervous system development|nucleoside metabolic process|purine nucleotide biosynthetic process|pyrimidine nucleotide biosynthetic process|ribonucleoside monophosphate biosynthetic process|urate biosynthetic process	cytosol	ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			breast(3)|large_intestine(1)	4						AATCTTCTCCGGTCCTGCTAT	0.443			NA											28	66					1.39806e-14	2.2521e-14	0.008361	1	0
COL4A5	1287	broad.mit.edu	37	X	107814669	107814669	+	Silent	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:107814669C>G	uc004enz.1	+	7	613	c.411C>G	c.(409-411)CCC>CCG	p.P137P	COL4A5_uc011mso.1_Silent_p.P137P	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	137	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						CAGGCAGTCCCGGTTTTCCTG	0.393			NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				50	127					0	0	0.00361	0	0
TRPC5	7224	broad.mit.edu	37	X	111155894	111155894	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:111155894G>T	uc004epl.1	-	3	1444	c.525C>A	c.(523-525)CGC>CGA	p.R175R	TRPC5_uc004epm.1_Silent_p.R175R	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	175	Cytoplasmic (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						CACAGTTGCAGCGGATCTGGT	0.537			NA											26	35					4.72057e-08	6.2941e-08	0.003954	1	0
SLC25A43	203427	broad.mit.edu	37	X	118544216	118544216	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:118544216G>T	uc004erd.2	+	3	925	c.581G>T	c.(580-582)GGA>GTA	p.G194V	SLC25A43_uc004erc.1_RNA|SLC25A43_uc011mtt.1_Intron	NM_145305	NP_660348	Q8WUT9	S2543_HUMAN	mitochondrial solute carrier protein	194					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			skin(1)	1						ATCTGGAACGGACCCCGAGAT	0.527			NA											50	51					5.13769e-22	8.99095e-22	0.00361	1	0
SLC25A14	9016	broad.mit.edu	37	X	129492640	129492640	+	Silent	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:129492640G>A	uc004evn.1	+	7	738	c.525G>A	c.(523-525)TTG>TTA	p.L175L	SLC25A14_uc011mut.1_Missense_Mutation_p.V112I|SLC25A14_uc011muu.1_Silent_p.L175L|SLC25A14_uc010nrg.2_Silent_p.L172L|SLC25A14_uc004evo.1_5'UTR|SLC25A14_uc004evp.1_Silent_p.L175L|SLC25A14_uc004evq.1_Silent_p.L172L|SLC25A14_uc004evr.1_Silent_p.L172L	NM_003951	NP_003942	O95258	UCP5_HUMAN	solute carrier family 25, member 14 isoform	175	Solcar 2.				aerobic respiration|mitochondrial transport	integral to plasma membrane|mitochondrial inner membrane	binding			ovary(1)	1						AAGGAAGCTTGTTCCAAGGGA	0.368			NA											24	39					0	0	0.008361	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130215686	130215686	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:130215686C>A	uc004evz.2	+	2	392	c.47C>A	c.(46-48)CCC>CAC	p.P16H	ARHGAP36_uc004ewa.2_Intron|ARHGAP36_uc004ewb.2_Intron|ARHGAP36_uc004ewc.2_5'Flank	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	16					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						GCACTGTGCCCCAGAATCATG	0.527			NA											39	57					1.49673e-21	2.61038e-21	0.00623	1	0
GPC3	2719	broad.mit.edu	37	X	133087218	133087218	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:133087218G>T	uc004exe.1	-	2	386	c.196C>A	c.(196-198)CTC>ATC	p.L66I	GPC3_uc010nrn.1_Missense_Mutation_p.L66I|GPC3_uc011mvh.1_Missense_Mutation_p.L66I|GPC3_uc010nro.1_Intron|GPC3_uc010nrp.1_5'UTR	NM_004484	NP_004475	P51654	GPC3_HUMAN	glypican 3 isoform 2 precursor	66						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			lung(2)|prostate(1)|breast(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					CCCTTAGGGAGACATACTTGC	0.468			NA	T|D|Mis|N|F|S			Wilms tumour			Simpson-Golabi-Behmel_syndrome				57	66					1.67886e-27	3.0597e-27	0.00361	1	0
GPR112	139378	broad.mit.edu	37	X	135487937	135487937	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:135487937G>T	uc004ezu.1	+	23	9032	c.8741G>T	c.(8740-8742)TGC>TTC	p.C2914F	GPR112_uc010nsb.1_Missense_Mutation_p.C2709F	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2914	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TCCATGTTCTGCACTGTTCTT	0.398			NA											37	39					9.8876e-21	1.71089e-20	0.004878	1	0
CD40LG	959	broad.mit.edu	37	X	135741286	135741286	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:135741286A>C	uc004faa.2	+	5	570	c.498A>C	c.(496-498)CAA>CAC	p.Q166H	CD40LG_uc010nsd.2_Missense_Mutation_p.Q145H	NM_000074	NP_000065	P29965	CD40L_HUMAN	CD40 ligand	166	Extracellular (Potential).				anti-apoptosis|B cell proliferation|inflammatory response|isotype switching|leukocyte cell-cell adhesion|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of interleukin-12 production	extracellular space|integral to plasma membrane|soluble fraction	CD40 receptor binding|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)				Atorvastatin(DB01076)	TTAAAAGACAAGGACTCTATT	0.453			NA							Immune_Deficiency_with_Hyper-IgM				116	177					0	0	0.00361	0	0
GPR101	83550	broad.mit.edu	37	X	136113092	136113092	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:136113092C>G	uc011mwh.1	-	1	742	c.742G>C	c.(742-744)GAG>CAG	p.E248Q		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	248	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					TCTGCTCCCTCTTCATCCTCA	0.547			NA											16	139					0	0	0.006122	0	0
F9	2158	broad.mit.edu	37	X	138623303	138623303	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:138623303G>A	uc004fas.1	+	4	375	c.346G>A	c.(346-348)GAA>AAA	p.E116K	F9_uc004fat.1_Intron	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	116	EGF-like 1; calcium-binding (Potential).				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	TAATTCCTATGAATGTTGGTG	0.368			NA											4	49					0	0	0.009096	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995906	140995906	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:140995906T>A	uc004fbt.2	+	4	3002	c.2716T>A	c.(2716-2718)TAT>AAT	p.Y906N	MAGEC1_uc010nsl.1_5'UTR	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	906							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CTTGTTCACTTATACACTGGA	0.468			NA								HNSCC(15;0.026)			35	163					0	0	0.003755	0	0
SLITRK4	139065	broad.mit.edu	37	X	142718172	142718172	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:142718172C>G	uc004fbx.2	-	2	1129	c.753G>C	c.(751-753)AGG>AGC	p.R251S	SLITRK4_uc004fby.2_Missense_Mutation_p.R251S	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	251	Extracellular (Potential).|LRRCT 1.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CTTTTAAAAGCCTTCCATATA	0.443			NA											14	21					0	0	0.001855	0	0
SPANXN2	494119	broad.mit.edu	37	X	142803913	142803913	+	Translation_Start_Site	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:142803913T>A	uc004fbz.2	-	1	604	c.-150A>T	c.(-152--148)AAAGC>AATGC			NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein											ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					ACTCTTGAGCTTTGTTTGATC	0.542			NA											5	6					0	0	0.000602	0	0
MTMR1	8776	broad.mit.edu	37	X	149901077	149901077	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:149901077G>T	uc004fei.2	+	9	1066	c.931G>T	c.(931-933)GGT>TGT	p.G311C	MTMR1_uc011mya.1_Missense_Mutation_p.G217C|MTMR1_uc004feg.1_Missense_Mutation_p.G311C|MTMR1_uc004feh.1_Missense_Mutation_p.G319C|MTMR1_uc004fej.2_RNA|MTMR1_uc010ntf.2_RNA	NM_003828	NP_003819	Q13613	MTMR1_HUMAN	myotubularin-related protein 1	311	Myotubularin phosphatase.					plasma membrane	protein tyrosine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GCCACTTGTGGGTCCCAATGA	0.418			NA											8	15					2.17888e-05	2.60114e-05	0.006214	1	0
CNGA2	1260	broad.mit.edu	37	X	150912786	150912786	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:150912786T>A	uc004fey.1	+	7	2035	c.1811T>A	c.(1810-1812)CTG>CAG	p.L604Q		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	604	Cytoplasmic (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CTAGGGCAGCTGGAGACCAAC	0.582			NA											29	60					0	0	0.00632	0	0
GABRQ	55879	broad.mit.edu	37	X	151820193	151820193	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:151820193G>A	uc004ffp.1	+	8	1126	c.1106G>A	c.(1105-1107)CGA>CAA	p.R369Q		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	369						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AGGAGACCCCGAAGAGTCATT	0.517			NA											12	61					0	0	0.000978	0	0
MAGEA3	4102	broad.mit.edu	37	X	151935453	151935453	+	Silent	SNP	G	G	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:151935453G>T	uc004fgp.2	-	3	923	c.714C>A	c.(712-714)ATC>ATA	p.I238I		NM_005362	NP_005353	P43357	MAGA3_HUMAN	melanoma antigen family A, 3	238	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GATCCCCCAAGATACTGTCTT	0.542			NA											72	104					2.94884e-30	5.47794e-30	0.00361	1	0
L1CAM	3897	broad.mit.edu	37	X	153137770	153137770	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:153137770C>A	uc004fjb.2	-	4	345	c.237G>T	c.(235-237)AAG>AAT	p.K79N	L1CAM_uc004fjc.2_Missense_Mutation_p.K79N|L1CAM_uc010nuo.2_Missense_Mutation_p.K74N|L1CAM_uc004fjd.1_5'Flank|L1CAM_uc004fje.1_Missense_Mutation_p.K74N	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	79	Extracellular (Potential).|Ig-like C2-type 1.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCAGCTCTTCCTTGGGTTTGA	0.607			NA											9	12					0.00621372	0.00674832	0.006214	1	0
PLXNA3	55558	broad.mit.edu	37	X	153688868	153688868	+	Silent	SNP	C	C	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:153688868C>T	uc004flm.2	+	2	518	c.345C>T	c.(343-345)ATC>ATT	p.I115I		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	115	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCGGCAGCATCTGGCAGGGCA	0.672			NA											11	28					0	0	0.000978	0	0
OR6Y1	391112	broad.mit.edu	37	1	158516969	158516969	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:158516969delG	uc010pil.1	-	1	927	c.927delC	c.(925-927)ACCfs	p.T309fs		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	309	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TGCAATGTATGGTCTTTCTGA	0.443			NA											40	76	---	---	---	---	NA	NA	NA	NA	NA
EDEM3	80267	broad.mit.edu	37	1	184692959	184692960	+	Frame_Shift_Ins	INS	-	-	A			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:184692959_184692960insA	uc010pok.1	-	8	1039_1040	c.778_779insT	c.(778-780)TGGfs	p.W260fs	EDEM3_uc010pol.1_RNA|EDEM3_uc010pom.1_Frame_Shift_Ins_p.W260fs|EDEM3_uc001gqy.2_Frame_Shift_Ins_p.W183fs	NM_025191	NP_079467	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like	260					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			skin(1)	1						TCTTTTTTCCCAGAGAAAATCA	0.312			NA											35	119	---	---	---	---	NA	NA	NA	NA	NA
C1orf31	388753	broad.mit.edu	37	1	234510050	234510050	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:234510050delG	uc001hwc.2	+	2	233	c.197delG	c.(196-198)TGGfs	p.W66fs	C1orf31_uc001hwb.2_Frame_Shift_Del_p.W20fs	NM_001012985	NP_001013003	Q5JTJ3	CA031_HUMAN	hypothetical protein LOC388753	66						mitochondrion	cytochrome-c oxidase activity				0	Ovarian(103;0.0339)	all_cancers(173;0.241)|Prostate(94;0.0353)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			GATGAGTACTGGAAGTGTTTA	0.458			NA											47	122	---	---	---	---	NA	NA	NA	NA	NA
RYR2	6262	broad.mit.edu	37	1	237758850	237758850	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr1:237758850delG	uc001hyl.1	+	34	4609	c.4489delG	c.(4489-4491)GGGfs	p.G1497fs		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1497	Cytoplasmic (By similarity).|B30.2/SPRY 3.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CATGAGCCCCGGGCAAGGACG	0.473			NA											22	67	---	---	---	---	NA	NA	NA	NA	NA
CHST1	8534	broad.mit.edu	37	11	45671427	45671427	+	Frame_Shift_Del	DEL	G	G	-	rs148878468	byFrequency	TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr11:45671427delG	uc001mys.1	-	4	1718	c.1047delC	c.(1045-1047)ACCfs	p.T349fs		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	349	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		AGTTTCGCACGGTGCCGTATT	0.672			NA											24	94	---	---	---	---	NA	NA	NA	NA	NA
PCDH17	27253	broad.mit.edu	37	13	58208014	58208014	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:58208014delG	uc001vhq.1	+	1	2226	c.1334delG	c.(1333-1335)CGGfs	p.R445fs	PCDH17_uc010aec.1_Frame_Shift_Del_p.R445fs	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	445	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		ATCGTGGCGCGGGACGGGGGC	0.582	Melanoma(72;952 1291 1619 12849 33676)		NA											8	29	---	---	---	---	NA	NA	NA	NA	NA
DACH1	1602	broad.mit.edu	37	13	72255995	72255995	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr13:72255995delG	uc010thn.1	-	3	1319	c.896delC	c.(895-897)CCAfs	p.P299fs	DACH1_uc010tho.1_Frame_Shift_Del_p.P299fs|DACH1_uc010thp.1_Frame_Shift_Del_p.P299fs	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	299	Interaction with SIX6 and HDAC3 (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		AGAGTTCTCTGGGGAGGTGAC	0.418			NA											13	78	---	---	---	---	NA	NA	NA	NA	NA
DNAL1	83544	broad.mit.edu	37	14	74125629	74125629	+	Frame_Shift_Del	DEL	A	A	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr14:74125629delA	uc001xoq.3	+	3	287	c.122delA	c.(121-123)GATfs	p.D41fs	DNAL1_uc010aru.2_Frame_Shift_Del_p.D2fs|DNAL1_uc010arv.2_Intron	NM_031427	NP_113615	Q4LDG9	DNAL1_HUMAN	axonemal dynein light chain 1	41											0				BRCA - Breast invasive adenocarcinoma(234;0.00384)|KIRC - Kidney renal clear cell carcinoma(182;0.095)		GAGAAGATGGATGCATCCTTG	0.403			NA											154	340	---	---	---	---	NA	NA	NA	NA	NA
GTF3C1	2975	broad.mit.edu	37	16	27517400	27517401	+	Frame_Shift_Ins	INS	-	-	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:27517400_27517401insT	uc002dov.1	-	10	1629_1630	c.1589_1590insA	c.(1588-1590)AAGfs	p.K530fs	GTF3C1_uc002dou.2_Frame_Shift_Ins_p.K530fs	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	530						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						AGGGCGGCTGCTTTTTCAATGG	0.554			NA											14	74	---	---	---	---	NA	NA	NA	NA	NA
ITGAX	3687	broad.mit.edu	37	16	31388578	31388578	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:31388578delG	uc002ebu.1	+	23	2848	c.2781delG	c.(2779-2781)GTGfs	p.V927fs	ITGAX_uc002ebt.2_Frame_Shift_Del_p.V927fs	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	927	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCTACACTGTGGTTAGCAGGT	0.502			NA											20	74	---	---	---	---	NA	NA	NA	NA	NA
RFWD3	55159	broad.mit.edu	37	16	74678502	74678502	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr16:74678502delC	uc002fda.2	-	5	1022	c.924delG	c.(922-924)GGGfs	p.G308fs	RFWD3_uc010cgq.2_Frame_Shift_Del_p.G308fs	NM_018124	NP_060594	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	308	RING-type; degenerate.				DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(1)	3						CAAAGAGATGCCCACAGCGTA	0.478			NA											7	108	---	---	---	---	NA	NA	NA	NA	NA
OR3A1	4994	broad.mit.edu	37	17	3195709	3195709	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:3195709delG	uc002fvh.1	-	1	168	c.168delC	c.(166-168)CCCfs	p.P56fs		NM_002550	NP_002541	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A,	56	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|central_nervous_system(1)	3						TGTGGAGTTTGGGCTCCACCA	0.562	GBM(20;287 516 18743 28660 36594)		NA											14	46	---	---	---	---	NA	NA	NA	NA	NA
C17orf63	55731	broad.mit.edu	37	17	27085451	27085451	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:27085451delC	uc002hct.1	-	3	1793	c.1526delG	c.(1525-1527)AGCfs	p.S509fs	C17orf63_uc010wax.1_Frame_Shift_Del_p.S509fs|C17orf63_uc010way.1_Frame_Shift_Del_p.S509fs|C17orf63_uc002hcw.2_Frame_Shift_Del_p.S381fs	NM_018182	NP_060652	Q8WU58	CQ063_HUMAN	hypothetical protein LOC55731	509										ovary(1)	1	all_epithelial(6;5.06e-20)|Lung NSC(42;0.01)		Epithelial(11;3.38e-06)|all cancers(11;2.46e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.104)			TTGCATCAAGCTGTTCTGGCT	0.652			NA											8	68	---	---	---	---	NA	NA	NA	NA	NA
ARSG	22901	broad.mit.edu	37	17	66352843	66352851	+	In_Frame_Del	DEL	TCCCTCTTT	TCCCTCTTT	-	rs115207014	byFrequency	TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	TCCCTCTTT	TCCCTCTTT	-	-	TCCCTCTTT	TCCCTCTTT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr17:66352843_66352851delTCCCTCTTT	uc002jhc.2	+	6	1398_1406	c.602_610delTCCCTCTTT	c.(601-612)CTCCCTCTTTAT>CAT	p.201_204LPLY>H	ARSG_uc002jhb.1_In_Frame_Del_p.37_40LPLY>H	NM_014960	NP_055775	Q96EG1	ARSG_HUMAN	Arylsulfatase G precursor	201_204					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			GACGTGGCCCTCCCTCTTTATGAAAACCT	0.493			NA											17	38	---	---	---	---	NA	NA	NA	NA	NA
PSG4	5672	broad.mit.edu	37	19	43699272	43699272	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr19:43699272delC	uc002ovy.2	-	4	965	c.863delG	c.(862-864)CGAfs	p.R288fs	PSG6_uc010xwk.1_Intron|PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Frame_Shift_Del_p.R195fs|PSG4_uc002ovz.2_Intron	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	288	Ig-like C2-type 2.				defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				TTCAATGGGTCGCTTTACCCT	0.463			NA											215	322	---	---	---	---	NA	NA	NA	NA	NA
REG3A	5068	broad.mit.edu	37	2	79386508	79386508	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:79386508delG	uc002sod.1	-	1	279	c.24delC	c.(22-24)CCCfs	p.P8fs	REG3A_uc002soe.1_Frame_Shift_Del_p.P8fs|REG3A_uc002sof.1_Frame_Shift_Del_p.P8fs	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	8					acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						AAGATACACTGGGCAGGGCCA	0.532			NA											11	77	---	---	---	---	NA	NA	NA	NA	NA
FIGN	55137	broad.mit.edu	37	2	164467481	164467481	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:164467481delG	uc002uck.1	-	3	1172	c.861delC	c.(859-861)CCCfs	p.P287fs		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	287	Pro-rich.					nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						GAACAGTGGTGGGGGGTAGGG	0.592			NA											7	94	---	---	---	---	NA	NA	NA	NA	NA
FARP2	9855	broad.mit.edu	37	2	242407622	242407622	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr2:242407622delG	uc002wbi.1	+	18	2078	c.1961delG	c.(1960-1962)TGTfs	p.C654fs		NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	654	DH.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		ACCAAACGCTGTAAGAAGTTG	0.527			NA											78	128	---	---	---	---	NA	NA	NA	NA	NA
CST8	10047	broad.mit.edu	37	20	23472391	23472391	+	Frame_Shift_Del	DEL	A	A	-	rs2983288	byFrequency	TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr20:23472391delA	uc002wth.1	+	2	444	c.87delA	c.(85-87)ACAfs	p.T29fs		NM_005492	NP_005483	O60676	CST8_HUMAN	cystatin 8 precursor	29						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					AGAATGAGACAGGGGTGCTGA	0.537			NA											7	164	---	---	---	---	NA	NA	NA	NA	NA
APOL2	23780	broad.mit.edu	37	22	36623735	36623736	+	In_Frame_Ins	INS	-	-	GGG			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:36623735_36623736insGGG	uc003aoz.2	-	5	1064_1065	c.728_729insCCC	c.(727-729)CCG>CCCCCG	p.243_243P>PP	APOL2_uc011amm.1_In_Frame_Ins_p.355_355P>PP|APOL2_uc003apa.2_In_Frame_Ins_p.243_243P>PP	NM_030882	NP_112092	Q9BQE5	APOL2_HUMAN	apolipoprotein L2	243					acute-phase response|cholesterol metabolic process|lipid transport|lipoprotein metabolic process|maternal process involved in female pregnancy|multicellular organismal development	endoplasmic reticulum membrane|extracellular region	high-density lipoprotein particle binding|lipid binding|receptor binding				0						CAATGATATGCGGGGGTGGGGC	0.564			NA											20	130	---	---	---	---	NA	NA	NA	NA	NA
DDX17	10521	broad.mit.edu	37	22	38882078	38882078	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr22:38882078delC	uc003avy.3	-	13	2161	c.2058delG	c.(2056-2058)CGGfs	p.R686fs	DDX17_uc003avw.3_Frame_Shift_Del_p.R138fs|DDX17_uc010gxp.2_Frame_Shift_Del_p.R136fs|DDX17_uc003avx.3_Frame_Shift_Del_p.R684fs	NM_001098504	NP_001091974	Q92841	DDX17_HUMAN	DEAD box polypeptide 17 isoform 3	605					RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity			skin(3)|upper_aerodigestive_tract(1)	4	Melanoma(58;0.0286)					GCTGCCCAGACCGGCCTATCC	0.527	Ovarian(55;1085 1454 6392 21425)		NA											8	130	---	---	---	---	NA	NA	NA	NA	NA
TP63	8626	broad.mit.edu	37	3	189587113	189587113	+	Frame_Shift_Del	DEL	C	C	-	rs148052765		TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr3:189587113delC	uc003fry.2	+	9	1219	c.1130delC	c.(1129-1131)CCGfs	p.P377fs	TP63_uc003frx.2_Frame_Shift_Del_p.P377fs|TP63_uc003frz.2_Frame_Shift_Del_p.P377fs|TP63_uc010hzc.1_Frame_Shift_Del_p.P377fs|TP63_uc003fsa.2_Frame_Shift_Del_p.P283fs|TP63_uc003fsb.2_Frame_Shift_Del_p.P283fs|TP63_uc003fsc.2_Frame_Shift_Del_p.P283fs|TP63_uc003fsd.2_Frame_Shift_Del_p.P283fs|TP63_uc010hzd.1_Frame_Shift_Del_p.P198fs|TP63_uc003fse.1_Frame_Shift_Del_p.A254fs	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	377	Interaction with HIPK2.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CCTCCACCAGCGTTTCGTCAG	0.343			NA							Hay-Wells_syndrome	HNSCC(45;0.13)			13	70	---	---	---	---	NA	NA	NA	NA	NA
HEATR7B2	133558	broad.mit.edu	37	5	41018522	41018523	+	Frame_Shift_Ins	INS	-	-	T			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr5:41018522_41018523insT	uc003jmj.3	-	27	3173_3174	c.2683_2684insA	c.(2683-2685)ATGfs	p.M895fs	HEATR7B2_uc003jmi.3_Frame_Shift_Ins_p.M450fs	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	895							binding			ovary(6)|central_nervous_system(2)	8						AACAAGCCACATTTGGAGAAGC	0.366			NA											10	40	---	---	---	---	NA	NA	NA	NA	NA
PCLO	27445	broad.mit.edu	37	7	82580348	82580348	+	Frame_Shift_Del	DEL	T	T	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:82580348delT	uc003uhx.2	-	6	9845	c.9556delA	c.(9556-9558)ACAfs	p.T3186fs	PCLO_uc003uhv.2_Frame_Shift_Del_p.T3186fs|PCLO_uc010lec.2_Frame_Shift_Del_p.T151fs	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3117					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TCGGATGCTGTGGTTAAAGTG	0.438			NA											16	70	---	---	---	---	NA	NA	NA	NA	NA
HEPACAM2	253012	broad.mit.edu	37	7	92837962	92837962	+	Frame_Shift_Del	DEL	A	A	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr7:92837962delA	uc003umm.2	-	4	966	c.943delT	c.(943-945)TGCfs	p.C315fs	HEPACAM2_uc003uml.2_Frame_Shift_Del_p.C303fs|HEPACAM2_uc010lff.2_Frame_Shift_Del_p.C303fs|HEPACAM2_uc011khy.1_Frame_Shift_Del_p.C338fs	NM_001039372	NP_001034461	A8MVW5	HECA2_HUMAN	HEPACAM family member 2 isoform 1	315	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane				ovary(3)|breast(1)|kidney(1)	5						TAAGCACAGCACACATAGTCC	0.428			NA											23	131	---	---	---	---	NA	NA	NA	NA	NA
ZNF462	58499	broad.mit.edu	37	9	109686588	109686589	+	In_Frame_Ins	INS	-	-	AGCTCA			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chr9:109686588_109686589insAGCTCA	uc004bcz.2	+	3	684_685	c.395_396insAGCTCA	c.(394-396)GGA>GGAGCTCAA	p.134_135insAQ	ZNF462_uc010mto.2_5'UTR|ZNF462_uc004bda.2_5'UTR	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	134_135					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						AAGGTCCATGGAGCTCAAGCTG	0.441			NA											8	70	---	---	---	---	NA	NA	NA	NA	NA
DDX3X	1654	broad.mit.edu	37	X	41201812	41201812	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:41201812delG	uc004dfe.2	+	5	1204	c.349delG	c.(349-351)GGCfs	p.G117fs	DDX3X_uc010nhf.1_Frame_Shift_Del_p.G101fs|DDX3X_uc004dff.2_Frame_Shift_Del_p.G117fs|DDX3X_uc011mkq.1_Frame_Shift_Del_p.G101fs|DDX3X_uc011mkr.1_Frame_Shift_Del_p.G117fs|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA|DDX3X_uc011mkt.1_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	117					interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						AAGTGGCTTTGGCAAATTTGA	0.453			NA								HNSCC(61;0.18)			10	22	---	---	---	---	NA	NA	NA	NA	NA
CDX4	1046	broad.mit.edu	37	X	72674320	72674320	+	Frame_Shift_Del	DEL	T	T	-			TCGA-05-4410-01A-21D-1855-08	TCGA-05-4410-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f85d0d42-436b-4251-a7fd-7d0f5fddd397	e76567fb-2172-446f-87d3-afc4d7ef2b76	g.chrX:72674320delT	uc011mqk.1	+	3	754	c.754delT	c.(754-756)TCCfs	p.S252fs		NM_005193	NP_005184	O14627	CDX4_HUMAN	caudal type homeobox 4	252						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(35;0.156)					TGACTCTGACTCCATCAGCCC	0.448			NA											15	11	---	---	---	---	NA	NA	NA	NA	NA
