Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PTCHD2	57540	broad.mit.edu	37	1	11562047	11562047	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:11562047G>T	uc001ash.3	+	2	1136	c.998G>T	c.(997-999)TGC>TTC	p.C333F	PTCHD2_uc001asi.1_Missense_Mutation_p.C333F	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	333	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TACTCCTACTGCTCGCCCCCC	0.622			NA											5	48					3.59834e-05	4.318e-05	0.001168	1	0
UBXN10	127733	broad.mit.edu	37	1	20517245	20517245	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:20517245C>T	uc001bdb.2	+	2	275	c.191C>T	c.(190-192)CCA>CTA	p.P64L		NM_152376	NP_689589	Q96LJ8	UBX10_HUMAN	UBX domain protein 10	64										ovary(1)	1						CATCATATACCATCTCCGCCT	0.537			NA											9	76					0	0	0.008291	0	0
EIF4G3	8672	broad.mit.edu	37	1	21212859	21212859	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:21212859C>A	uc001bec.2	-	14	2347	c.2091G>T	c.(2089-2091)TTG>TTT	p.L697F	EIF4G3_uc010odi.1_Missense_Mutation_p.L301F|EIF4G3_uc010odj.1_Missense_Mutation_p.L696F|EIF4G3_uc009vpz.2_Missense_Mutation_p.L417F|EIF4G3_uc001bed.2_Missense_Mutation_p.L697F|EIF4G3_uc001bef.2_Missense_Mutation_p.L733F|EIF4G3_uc001bee.2_Missense_Mutation_p.L703F	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	697					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		ACCCAACATTCAACAACTAGG	0.398			NA											8	270					0.00307968	0.00335965	0.00308	1	0
C1orf94	84970	broad.mit.edu	37	1	34677938	34677938	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:34677938C>A	uc001bxs.3	+	6	1481	c.1082C>A	c.(1081-1083)TCT>TAT	p.S361Y	C1orf94_uc001bxt.2_Missense_Mutation_p.S551Y	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	361							protein binding				0		Myeloproliferative disorder(586;0.0393)				CCAAAGATGTCTGCCAACCCC	0.567			NA											5	64					0.00307968	0.00335965	0.00308	1	0
FUBP1	8880	broad.mit.edu	37	1	78430042	78430042	+	Splice_Site	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:78430042C>A	uc001dii.2	-	11	927	c.838_splice	c.e11-1	p.V280_splice	FUBP1_uc001dih.3_Splice_Site|FUBP1_uc010orm.1_Splice_Site_p.V301_splice	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein						transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						GAATGGGGACCTTATGTAAAA	0.338			NA											8	62					0.00448238	0.00484979	0.004482	1	0
COL24A1	255631	broad.mit.edu	37	1	86512537	86512537	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:86512537G>T	uc001dlj.2	-	12	1963	c.1921C>A	c.(1921-1923)CGT>AGT	p.R641S	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Missense_Mutation_p.R641S	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	641					cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		ttctttccacggatcccagga	0.179			NA											12	155					4.36969e-10	6.74619e-10	0.016723	1	0
LPPR5	163404	broad.mit.edu	37	1	99418685	99418685	+	Silent	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:99418685G>T	uc001dsb.2	-	3	784	c.562C>A	c.(562-564)CGA>AGA	p.R188R	LPPR5_uc001dsc.2_Silent_p.R188R	NM_001037317	NP_001032394	Q32ZL2	LPPR5_HUMAN	phosphatidic acid phosphatase type 2d isoform 1	188						integral to membrane	hydrolase activity				0						AAGGTTTTTCGGGCTCTCATG	0.423			NA											11	113					3.07112e-06	3.84254e-06	0.010729	1	0
Unknown	0	broad.mit.edu	37	1	104260732	104260732	+	Splice_Site	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:104260732G>T	uc010our.1	+	4	478	c.356_splice	c.e4+1	p.R119_splice		NM_000699	NP_000690			pancreatic amylase alpha 2A precursor												NA						GCCAAATAAGGTGAGAATATG	0.333			NA											34	581					3.77016e-25	7.59788e-25	0.013114	1	0
KCNA2	3737	broad.mit.edu	37	1	111146525	111146525	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:111146525G>A	uc001dzu.2	-	2	1376	c.880C>T	c.(880-882)CGT>TGT	p.R294C	KCNA2_uc009wfv.1_Missense_Mutation_p.R294C|KCNA2_uc009wfw.2_Missense_Mutation_p.R294C	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	294	Helical; Voltage-sensor; Name=Segment S4; (Potential).					juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		CGGATGACACGGAGGATGGCC	0.537	Pancreas(18;568 735 10587 23710 36357)		NA											11	140					0	0	0.00499	0	0
NBPF7	343505	broad.mit.edu	37	1	120384102	120384102	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:120384102C>A	uc010oxk.1	-	3	1081	c.460G>T	c.(460-462)GAT>TAT	p.D154Y		NM_001047980	NP_001041445	P0C2Y1	NBPF7_HUMAN	hypothetical protein LOC343505	154						cytoplasm				ovary(1)|skin(1)	2	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;3.66e-05)|Lung NSC(69;0.000192)|all_epithelial(167;0.0347)		Lung(183;0.0103)|LUSC - Lung squamous cell carcinoma(189;0.0544)		TCATGCTTATCCGGAGTGAGA	0.567			NA											24	179					9.57634e-11	1.55101e-10	0.01892	1	0
ADAM30	11085	broad.mit.edu	37	1	120438759	120438759	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:120438759C>A	uc001eij.2	-	1	355	c.201G>T	c.(199-201)CAG>CAT	p.Q67H		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	67					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		TGCCTTTTAACTGCAGTAGGT	0.542			NA											18	98					0.000132079	0.000154287	0.008871	1	0
SEMA4A	64218	broad.mit.edu	37	1	156126349	156126349	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:156126349C>G	uc001fnl.2	+	3	388	c.284C>G	c.(283-285)CCC>CGC	p.P95R	SEMA4A_uc009wrq.2_Missense_Mutation_p.P95R|SEMA4A_uc001fnm.2_Missense_Mutation_p.P95R|SEMA4A_uc001fnn.2_5'UTR|SEMA4A_uc001fno.2_Missense_Mutation_p.P95R	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	95	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					CCAGGGGTCCCCAGGCTAAAG	0.567			NA											15	43					0	0	0.00499	0	0
FCRL1	115350	broad.mit.edu	37	1	157771827	157771827	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:157771827G>A	uc001frg.2	-	5	877	c.764C>T	c.(763-765)CCC>CTC	p.P255L	FCRL1_uc001frf.2_RNA|FCRL1_uc001frh.2_Missense_Mutation_p.P255L|FCRL1_uc001fri.2_Missense_Mutation_p.P255L|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	255	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TCCTCCAGAGGGGGCCGACCT	0.582	GBM(54;482 1003 11223 30131 35730)		NA											33	99					0	0	0.012213	0	0
CD1D	912	broad.mit.edu	37	1	158152847	158152847	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:158152847C>A	uc001frr.2	+	5	1286	c.787C>A	c.(787-789)CTC>ATC	p.L263I	CD1D_uc009wss.2_Intron	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	263	Ig-like.|Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					GACATGGTATCTCCGAGCAAC	0.617			NA											26	107					6.38683e-12	1.07396e-11	0.008361	1	0
OR6K6	128371	broad.mit.edu	37	1	158724748	158724748	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:158724748C>A	uc001fsw.1	+	1	143	c.143C>A	c.(142-144)GCG>GAG	p.A48E		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	48	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					TTCCCGCATGCGCACAGAGGT	0.453			NA											33	277					9.17885e-22	1.80837e-21	0.015359	1	0
NIT1	4817	broad.mit.edu	37	1	161088936	161088937	+	Missense_Mutation	DNP	GG	GG	TT	rs144963228	byFrequency	TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:161088936_161088937GG>TT	uc001fxv.1	+	3	187_188	c.111_112GG>TT	c.(109-114)ATGGCT>ATTTCT	p.37_38MA>IS	PFDN2_uc001fxu.2_5'Flank|NIT1_uc001fxw.2_Missense_Mutation_p.37_38MA>IS|NIT1_uc001fxx.1_Missense_Mutation_p.1_2MA>IS|NIT1_uc001fxy.1_Missense_Mutation_p.1_2MA>IS|NIT1_uc010pka.1_Missense_Mutation_p.22_23MA>IS	NM_005600	NP_005591	Q86X76	NIT1_HUMAN	nitrilase 1	37_38					nitrogen compound metabolic process	mitochondrion	nitrilase activity				0	all_cancers(52;3.39e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CCAGAGCCATGGCTATCTCCTC	0.515			NA											31	126					0	0	0.004672	0	0
DUSP27	92235	broad.mit.edu	37	1	167096659	167096659	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:167096659G>T	uc001geb.1	+	5	2291	c.2291G>T	c.(2290-2292)GGG>GTG	p.G764V		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	764					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						AGCTGCCTGGGGGATGACCAA	0.567			NA											9	71					1.49906e-05	1.82374e-05	0.020292	1	0
TNR	7143	broad.mit.edu	37	1	175325510	175325510	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:175325510C>A	uc001gkp.1	-	14	3144	c.3063G>T	c.(3061-3063)ATG>ATT	p.M1021I	TNR_uc009wwu.1_Missense_Mutation_p.M1021I	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	1021	Fibronectin type-III 8.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TGGTGGCATACATGGTGGCAG	0.507			NA											26	137					4.26978e-12	7.22578e-12	0.01892	1	0
ANGPTL1	9068	broad.mit.edu	37	1	178834573	178834573	+	Silent	SNP	C	C	G			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:178834573C>G	uc001gma.2	-	3	815	c.339G>C	c.(337-339)GTG>GTC	p.V113V	RALGPS2_uc001gly.1_Intron|RALGPS2_uc001glz.2_Intron|RALGPS2_uc010pnb.1_Intron|ANGPTL1_uc001gmb.2_Silent_p.V113V|ANGPTL1_uc010pnc.1_Silent_p.V35V	NM_004673	NP_004664	O95841	ANGL1_HUMAN	angiopoietin-like 1 precursor	113	Potential.					extracellular space	receptor binding				0						TTACCTCATTCACAATGTTTC	0.438			NA											8	172					0	0	0.004482	0	0
TDRD5	163589	broad.mit.edu	37	1	179562935	179562935	+	Silent	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:179562935C>A	uc001gnf.1	+	3	823	c.573C>A	c.(571-573)ACC>ACA	p.T191T	TDRD5_uc010pnp.1_Silent_p.T191T	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	191	Lotus/OST-HTH 2.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						TAGAGCAGACCAGAGCAGGTT	0.433			NA											48	106					2.24722e-20	4.33041e-20	0.01441	1	0
FAM5C	339479	broad.mit.edu	37	1	190423996	190423996	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:190423996C>A	uc001gse.1	-	2	257	c.25G>T	c.(25-27)GCT>TCT	p.A9S	FAM5C_uc010pot.1_5'UTR	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	9						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					AACAATTCAGCACCAGCTCTG	0.478			NA											17	53					8.10497e-08	1.13815e-07	0.010504	1	0
ASPM	259266	broad.mit.edu	37	1	197057403	197057403	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:197057403T>A	uc001gtu.2	-	26	10401	c.10144A>T	c.(10144-10146)ACA>TCA	p.T3382S	ASPM_uc001gtv.2_Missense_Mutation_p.T1797S|ASPM_uc001gtw.3_Missense_Mutation_p.T1230S	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	3382					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						CTATTTGTTGTCTTCAGTAAA	0.333			NA											21	210					0	0	0.010504	0	0
PPP1R15B	84919	broad.mit.edu	37	1	204375279	204375279	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:204375279T>C	uc001hav.3	-	2	2488	c.2083A>G	c.(2083-2085)ATG>GTG	p.M695V		NM_032833	NP_116222	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	695					regulation of translation					ovary(1)|pancreas(1)	2	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			CTATTAAACATTCTTTCTCTG	0.403			NA											69	176					0	0	0.01441	0	0
SLC26A9	115019	broad.mit.edu	37	1	205897047	205897047	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:205897047C>T	uc001hdq.2	-	9	1198	c.1084G>A	c.(1084-1086)GAC>AAC	p.D362N	SLC26A9_uc001hdo.2_Missense_Mutation_p.D30N|SLC26A9_uc001hdp.2_Missense_Mutation_p.D362N	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	362						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			GAATCCACGTCGTAGCCGTGC	0.587			NA											13	108					0	0	0.004007	0	0
TRIM11	81559	broad.mit.edu	37	1	228584677	228584677	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:228584677C>A	uc001hss.2	-	5	1085	c.830G>T	c.(829-831)GGA>GTA	p.G277V	TRIM11_uc010pvx.1_Missense_Mutation_p.G276V|TRIM11_uc001hst.1_Missense_Mutation_p.G277V	NM_145214	NP_660215	Q96F44	TRI11_HUMAN	tripartite motif-containing 11	277	B30.2/SPRY.				response to virus	cytoplasm|nucleus	protein binding|zinc ion binding	p.G277*(1)		lung(3)|ovary(1)	4		Prostate(94;0.0724)				CTCTACCAGTCCCGGGACCCT	0.637			NA											11	82					6.31663e-08	8.96553e-08	0.003163	1	0
SIPA1L2	57568	broad.mit.edu	37	1	232574993	232574993	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:232574993C>A	uc001hvg.2	-	13	4050	c.3892G>T	c.(3892-3894)GCT>TCT	p.A1298S	SIPA1L2_uc001hvf.2_Missense_Mutation_p.A372S	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1298					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GCAGCATCAGCCCACTGCTCG	0.662			NA											16	47					1.56452e-12	2.68204e-12	0.007413	1	0
RYR2	6262	broad.mit.edu	37	1	237819276	237819276	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:237819276T>A	uc001hyl.1	+	53	8241	c.8121T>A	c.(8119-8121)GAT>GAA	p.D2707E		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2707	Modulator (Potential).|Cytoplasmic (By similarity).|3.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AACCTGTTGATACCTCAAAGT	0.358			NA											15	41					0	0	0.003163	0	0
FMN2	56776	broad.mit.edu	37	1	240370817	240370817	+	Missense_Mutation	SNP	T	T	G			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:240370817T>G	uc010pyd.1	+	5	2930	c.2705T>G	c.(2704-2706)CTG>CGG	p.L902R	FMN2_uc010pye.1_Missense_Mutation_p.L906R	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	902	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCTCCTCCTCTGCAGGGTACA	0.662			NA											13	103					0	0	0.014323	0	0
OR6F1	343169	broad.mit.edu	37	1	247875730	247875730	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:247875730T>A	uc001idj.1	-	1	328	c.328A>T	c.(328-330)ACA>TCA	p.T110S		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	110	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AAGTACTCTGTGCAGCCTAAT	0.498			NA											26	77					0	0	0.021523	0	0
OR2T6	254879	broad.mit.edu	37	1	248551067	248551067	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:248551067C>A	uc001iei.1	+	1	158	c.158C>A	c.(157-159)CCT>CAT	p.P53H		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AACATAGACCCTCATCTCCAC	0.458			NA											39	93					6.04917e-29	1.23797e-28	0.006999	1	0
OR2T6	254879	broad.mit.edu	37	1	248551409	248551409	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:248551409C>A	uc001iei.1	+	1	500	c.500C>A	c.(499-501)CCG>CAG	p.P167Q		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	167	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATGAGTCTCCCGTTCTGTGCC	0.537			NA											12	46					1.08611e-07	1.478e-07	0.010729	1	0
OR2T2	401992	broad.mit.edu	37	1	248616371	248616371	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:248616371G>T	uc001iek.1	+	1	273	c.273G>T	c.(271-273)AAG>AAT	p.K91N		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	91	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCAAGGACAAGACCATTTCCT	0.522			NA											47	300					9.59449e-18	1.80925e-17	0.01441	1	0
PRPF18	8559	broad.mit.edu	37	10	13655795	13655795	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr10:13655795C>T	uc001imp.2	+	7	782	c.634C>T	c.(634-636)CGC>TGC	p.R212C	PRPF18_uc001imq.2_Intron	NM_003675	NP_003666	Q99633	PRP18_HUMAN	PRP18 pre-mRNA processing factor 18 homolog	212					mRNA processing|RNA splicing	nuclear speck|spliceosomal complex				central_nervous_system(1)	1						TTATGTGAAACGCAGTGTGCA	0.453			NA											16	84					0	0	0.004007	0	0
LOC387646	387646	broad.mit.edu	37	10	27538888	27538888	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr10:27538888G>A	uc001its.2	-	1	2348	c.505C>T	c.(505-507)CAG>TAG	p.Q169*		NR_003525				SubName: Full=cDNA FLJ44924 fis, clone BRAMY3014555;												0						TCAGCAGTCTGTGGATGCTCA	0.498			NA											22	143					0	0	0.016522	0	0
OR52N2	390077	broad.mit.edu	37	11	5841641	5841641	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr11:5841641C>A	uc010qzp.1	+	1	76	c.76C>A	c.(76-78)CAC>AAC	p.H26N	TRIM5_uc001mbq.1_Intron	NM_001005174	NP_001005174	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N,	26	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGAAGCCACACACATCTGGAT	0.547			NA											8	85					1.61879e-10	2.59007e-10	0.013537	1	0
OR10A3	26496	broad.mit.edu	37	11	7960520	7960520	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr11:7960520G>T	uc010rbi.1	-	1	548	c.548C>A	c.(547-549)CCG>CAG	p.P183Q		NM_001003745	NP_001003745	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CTCTAGTACCGGGGGAGTCTC	0.433			NA											4	106					0.00909568	0.00960504	0.009096	1	0
IPO7	10527	broad.mit.edu	37	11	9463643	9463643	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr11:9463643A>G	uc001mho.2	+	24	3060	c.2918A>G	c.(2917-2919)AAT>AGT	p.N973S		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	973					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		CAAAATCGTAATCCTGTGTGG	0.403			NA											16	96					0	0	0.007413	0	0
SOX6	55553	broad.mit.edu	37	11	15994629	15994629	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr11:15994629C>A	uc001mme.2	-	16	2285	c.2252G>T	c.(2251-2253)GGA>GTA	p.G751V	SOX6_uc001mmd.2_Missense_Mutation_p.G714V|SOX6_uc001mmf.2_Missense_Mutation_p.G711V|SOX6_uc001mmg.2_Missense_Mutation_p.G718V	NM_001145819	NP_001139291	P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6 isoform 4	738					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3						AACACCTGTTCCTGTGGTGAT	0.468			NA											8	71					5.4927e-09	8.10097e-09	0.004482	1	0
LDLRAD3	143458	broad.mit.edu	37	11	36250716	36250716	+	Silent	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr11:36250716G>T	uc001mwk.1	+	6	844	c.807G>T	c.(805-807)GCG>GCT	p.A269A	LDLRAD3_uc010rey.1_Silent_p.A220A|LDLRAD3_uc010rez.1_Silent_p.A148A|LDLRAD3_uc010rfa.1_RNA	NM_174902	NP_777562	Q86YD5	LRAD3_HUMAN	low density lipoprotein receptor class A domain	269	Cytoplasmic (Potential).					integral to membrane	receptor activity			central_nervous_system(1)	1	all_lung(20;0.089)|Lung NSC(22;0.175)|all_epithelial(35;0.177)	all_hematologic(20;0.124)				ACAGGCCTGCGTGGTATGACC	0.592			NA											30	204					2.61193e-14	4.62785e-14	0.009535	1	0
LRRC4C	57689	broad.mit.edu	37	11	40136265	40136265	+	Silent	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr11:40136265G>T	uc001mxa.1	-	2	3542	c.1578C>A	c.(1576-1578)ACC>ACA	p.T526T	LRRC4C_uc001mxc.1_Silent_p.T522T|LRRC4C_uc001mxd.1_Silent_p.T522T|LRRC4C_uc001mxb.1_Silent_p.T522T	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	526					regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TGATGATTTTGGTAGTCTTCA	0.468			NA											12	87					4.3838e-07	5.75783e-07	0.016723	1	0
OR4A47	403253	broad.mit.edu	37	11	48510590	48510590	+	Silent	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr11:48510590C>A	uc010rhx.1	+	1	246	c.246C>A	c.(244-246)GGC>GGA	p.G82G		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	82	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G82S(1)		ovary(1)|skin(1)	2						TGATTTCAGGCTTGTTCTTTG	0.428			NA											27	178					7.26314e-15	1.3044e-14	0.007291	1	0
OR4P4	81300	broad.mit.edu	37	11	55406314	55406314	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr11:55406314A>G	uc010rij.1	+	1	481	c.481A>G	c.(481-483)ACC>GCC	p.T161A		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	161	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						GTTTCTTCTCACCATCTTTGT	0.393			NA											20	176					0	0	0.008871	0	0
OR5F1	338674	broad.mit.edu	37	11	55761412	55761412	+	Silent	SNP	C	C	G	rs144082157	byFrequency	TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr11:55761412C>G	uc010riv.1	-	1	690	c.690G>C	c.(688-690)TCG>TCC	p.S230S		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					TCCCCTCCCCCGAATGCATAG	0.478			NA											8	41					0	0	0.00308	0	0
OR5AP2	338675	broad.mit.edu	37	11	56409316	56409316	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr11:56409316G>T	uc001njb.1	-	1	600	c.600C>A	c.(598-600)TTC>TTA	p.F200L		NM_001002925	NP_001002925	Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP,	200	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4						CAATGCCATTGAAGTGGGTAT	0.423			NA											30	192					4.62619e-21	8.98025e-21	0.019004	1	0
OR10W1	81341	broad.mit.edu	37	11	58035114	58035114	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr11:58035114G>T	uc001nmq.1	-	1	619	c.217C>A	c.(217-219)CTG>ATG	p.L73M		NM_207374	NP_997257	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W,	73	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				GTGTTGGCCAGGATATGGGGC	0.507			NA											15	78					1.15088e-07	1.55016e-07	0.004007	1	0
AHNAK	79026	broad.mit.edu	37	11	62287633	62287633	+	Silent	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr11:62287633G>A	uc001ntl.2	-	5	14556	c.14256C>T	c.(14254-14256)GGC>GGT	p.G4752G	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4752					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CAGCTTCTGGGCCCTTGAGGT	0.507			NA											23	206					0	0	0.014323	0	0
C11orf68	83638	broad.mit.edu	37	11	65685409	65685409	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr11:65685409C>A	uc001ogi.2	-	2	432	c.403G>T	c.(403-405)GTG>TTG	p.V135L	C11orf68_uc009yqv.2_Missense_Mutation_p.V134L|DRAP1_uc001ogj.1_5'Flank	NM_001135635	NP_001129107	Q9H3H3	CK068_HUMAN	basophilic leukemia expressed protein BLES03	93											0				READ - Rectum adenocarcinoma(159;0.166)		AGGCCCTGCACGTCCCCGGAG	0.657			NA											5	51					0.000442599	0.000503648	0.006214	1	0
PAFAH1B2	5049	broad.mit.edu	37	11	117038323	117038323	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr11:117038323G>T	uc001pqe.1	+	6	700	c.598G>T	c.(598-600)GGG>TGG	p.G200W	PAFAH1B2_uc009yzk.1_Intron|PAFAH1B2_uc009yzl.1_Intron|PAFAH1B2_uc009yzm.2_Intron|PAFAH1B2_uc009yzn.2_Intron|PAFAH1B2_uc009yzj.1_RNA|uc001pqf.2_5'Flank	NM_002572	NP_002563	P68402	PA1B2_HUMAN	platelet-activating factor acetylhydrolase,	200					lipid catabolic process	cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity			kidney(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;1.68e-05)|Epithelial(105;0.000162)|all cancers(92;0.00111)		TCTGACAGGAGGGGGCTATGC	0.532			NA	T	IGH@	MLCLS								7	67					0.00010058	0.000118014	0.013537	1	0
SCN3B	55800	broad.mit.edu	37	11	123508905	123508905	+	Silent	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr11:123508905G>T	uc001pza.1	-	5	980	c.573C>A	c.(571-573)GCC>GCA	p.A191A	SCN3B_uc001pzb.1_Silent_p.A191A	NM_001040151	NP_001035241	Q9NY72	SCN3B_HUMAN	voltage-gated sodium channel beta-3 subunit	191	Cytoplasmic (Potential).				axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		CGTTTTCTTGGGCTGCCTCTT	0.308			NA											10	41					2.17888e-05	2.63864e-05	0.006214	1	0
DDX11	1663	broad.mit.edu	37	12	31249876	31249876	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr12:31249876G>T	uc001rjt.1	+	17	1965	c.1714G>T	c.(1714-1716)GCT>TCT	p.A572S	DDX11_uc001rjr.1_Missense_Mutation_p.A572S|DDX11_uc001rjs.1_Missense_Mutation_p.A572S|DDX11_uc001rju.1_Missense_Mutation_p.A250S|DDX11_uc001rjv.1_Missense_Mutation_p.A572S|DDX11_uc001rjw.1_Missense_Mutation_p.A546S|DDX11_uc009zjn.1_RNA	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	572					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					CTTCCTGGCAGCTCTCACTAC	0.602			NA								Multiple Myeloma(12;0.14)			4	30					0.00909568	0.00960504	0.009096	1	0
IRAK4	51135	broad.mit.edu	37	12	44180315	44180315	+	Silent	SNP	T	T	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr12:44180315T>C	uc001rnu.3	+	12	1432	c.1302T>C	c.(1300-1302)AGT>AGC	p.S434S	IRAK4_uc001rnt.3_Silent_p.S434S|IRAK4_uc001rnx.3_Silent_p.S310S|IRAK4_uc001rny.3_Silent_p.S310S|IRAK4_uc010sky.1_Silent_p.S310S|IRAK4_uc001rnv.3_Silent_p.S310S|IRAK4_uc001rnw.3_Silent_p.S310S	NM_001114182	NP_001107654	Q9NWZ3	IRAK4_HUMAN	interleukin-1 receptor-associated kinase 4	434	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0	all_cancers(12;0.00149)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.04)		CTGTTGCTAGTCAATGTCTGC	0.308			NA											18	176					0	0	0.010504	0	0
PCBP2	5094	broad.mit.edu	37	12	53853102	53853102	+	Missense_Mutation	SNP	C	C	T	rs111807426		TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr12:53853102C>T	uc001sdl.3	+	6	640	c.290C>T	c.(289-291)CCG>CTG	p.P97L	PCBP2_uc001sdc.3_Missense_Mutation_p.P97L|PCBP2_uc001sdb.3_Missense_Mutation_p.P97L|PCBP2_uc001sde.3_Missense_Mutation_p.P97L|PCBP2_uc001sdi.3_Missense_Mutation_p.P97L|PCBP2_uc001sdd.3_Missense_Mutation_p.P97L|PCBP2_uc001sdf.3_Missense_Mutation_p.P97L|PCBP2_uc009zna.2_Missense_Mutation_p.P58L|PCBP2_uc010soh.1_Missense_Mutation_p.P97L|PCBP2_uc009zmz.1_Missense_Mutation_p.P39L|PCBP2_uc001sdg.1_RNA	NM_001128911	NP_001122383	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2 isoform d	97	KH 2.				innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding				0						AGTAGACCCCCGGTCACCCTG	0.488			NA											13	95					0	0	0.010504	0	0
PAN2	9924	broad.mit.edu	37	12	56720127	56720127	+	Silent	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr12:56720127C>T	uc001skx.2	-	8	1702	c.1329G>A	c.(1327-1329)GCG>GCA	p.A443A	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Silent_p.A443A|PAN2_uc001sky.2_Silent_p.A443A	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	443					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						GGGGATTGGGCGCATAGCCAA	0.542			NA											4	20					0	0	0.009096	0	0
RBMS2	5939	broad.mit.edu	37	12	56963712	56963712	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr12:56963712T>C	uc001sln.2	+	4	521	c.322T>C	c.(322-324)TCA>CCA	p.S108P	RBMS2_uc010sqp.1_5'UTR|RBMS2_uc010sqq.1_5'UTR|RBMS2_uc009zou.2_5'UTR	NM_002898	NP_002889	Q15434	RBMS2_HUMAN	RNA binding motif, single stranded interacting	108	RRM 1.				RNA processing	nucleus	nucleotide binding|RNA binding				0						TGACAGCCCTTCAGCAGCACA	0.512			NA											18	115					0	0	0.006122	0	0
INHBC	3626	broad.mit.edu	37	12	57843212	57843212	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr12:57843212G>T	uc001snv.1	+	2	593	c.466G>T	c.(466-468)GGT>TGT	p.G156C		NM_005538	NP_005529	P55103	INHBC_HUMAN	inhibin beta C chain preproprotein	156					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding				0						CCTTGTGCTGGGTCCACATAA	0.552			NA											34	162					3.21399e-22	6.42799e-22	0.021022	1	0
ANKS1B	56899	broad.mit.edu	37	12	99640640	99640640	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr12:99640640C>A	uc001tge.1	-	13	2176	c.1759G>T	c.(1759-1761)GAC>TAC	p.D587Y	ANKS1B_uc001tgf.1_Missense_Mutation_p.D167Y|ANKS1B_uc001tgk.2_5'UTR|ANKS1B_uc009ztt.1_Missense_Mutation_p.D553Y	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	587						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		CGGGAGAGGTCATCTGCAAAA	0.473			NA											35	238					1.66425e-11	2.76328e-11	0.021022	1	0
SLC17A8	246213	broad.mit.edu	37	12	100787146	100787146	+	Splice_Site	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr12:100787146G>A	uc010svi.1	+	4	787	c.474_splice	c.e4-1	p.R158_splice	SLC17A8_uc009ztx.2_Splice_Site_p.R158_splice	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent						neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						TGGTCCCCCAGGGTCTTTGGA	0.453			NA											10	70					0	0	0.006214	0	0
SLC17A8	246213	broad.mit.edu	37	12	100787197	100787197	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr12:100787197C>T	uc010svi.1	+	4	837	c.524C>T	c.(523-525)CCC>CTC	p.P175L	SLC17A8_uc009ztx.2_Missense_Mutation_p.P175L	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	175	Vesicular (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						ATGTTTATTCCCTCTGCAGCC	0.463			NA											7	102					0	0	0.008291	0	0
POLR3B	55703	broad.mit.edu	37	12	106821053	106821053	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr12:106821053A>T	uc001tlp.2	+	13	1402	c.1180A>T	c.(1180-1182)AAG>TAG	p.K394*	POLR3B_uc001tlq.2_Nonsense_Mutation_p.K336*	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	394					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						GGTGATTCCTAAGCAAAGAGC	0.363			NA											9	103					0	0	0.004482	0	0
TRPV4	59341	broad.mit.edu	37	12	110224614	110224614	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr12:110224614C>A	uc001tpj.1	-	13	2332	c.2237G>T	c.(2236-2238)CGC>CTC	p.R746L	TRPV4_uc001tpg.1_Missense_Mutation_p.R712L|TRPV4_uc001tph.1_Missense_Mutation_p.R699L|TRPV4_uc001tpi.1_Missense_Mutation_p.R639L|TRPV4_uc001tpk.1_Missense_Mutation_p.R746L|TRPV4_uc001tpl.1_Missense_Mutation_p.R686L	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	746	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						GGGGAAGGAGCGCTCAATGTC	0.652			NA											5	36					3.59834e-05	4.318e-05	0.001168	1	0
TBX5	6910	broad.mit.edu	37	12	114804095	114804095	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr12:114804095T>A	uc001tvo.2	-	8	1352	c.857A>T	c.(856-858)AAT>ATT	p.N286I	TBX5_uc001tvp.2_Missense_Mutation_p.N286I|TBX5_uc001tvq.2_Missense_Mutation_p.N236I|TBX5_uc010syv.1_Missense_Mutation_p.N286I	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	286					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		GGACCCCAAATTGGATGAGGT	0.577	NSCLC(152;1358 1980 4050 23898 40356)		NA											20	126					0	0	0.021523	0	0
TMEM132B	114795	broad.mit.edu	37	12	126137133	126137133	+	Silent	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr12:126137133C>A	uc001uhe.1	+	8	2054	c.2046C>A	c.(2044-2046)ATC>ATA	p.I682I	TMEM132B_uc001uhf.1_Silent_p.I194I	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	682	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AAAGGGCCATCGTCTCCACAG	0.607			NA											17	63					1.2644e-06	1.61257e-06	0.010504	1	0
SACS	26278	broad.mit.edu	37	13	23915491	23915491	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr13:23915491C>A	uc001uon.2	-	10	3113	c.2524G>T	c.(2524-2526)GAC>TAC	p.D842Y	SACS_uc001uoo.2_Missense_Mutation_p.D695Y|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	842					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TGTACAATGTCTGCTAAAAAT	0.363			NA											28	120					2.79863e-10	4.39785e-10	0.004656	1	0
FRY	10129	broad.mit.edu	37	13	32759184	32759184	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr13:32759184G>A	uc001utx.2	+	26	3714	c.3218G>A	c.(3217-3219)CGC>CAC	p.R1073H	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1073					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GACTTGACCCGCATGCTCCTA	0.418			NA											6	310					0	0	0.001168	0	0
ZC3H13	23091	broad.mit.edu	37	13	46619113	46619113	+	Silent	SNP	T	T	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr13:46619113T>C	uc010tfw.1	-	2	210	c.204A>G	c.(202-204)AAA>AAG	p.K68K	ZC3H13_uc001vas.1_Silent_p.K68K|ZC3H13_uc001vat.1_Silent_p.K68K	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	68							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TGCTATAACCTTTACCACGAG	0.378	Esophageal Squamous(187;747 2077 11056 31291 44172)		NA											5	147					0	0	0.014758	0	0
CYSLTR2	57105	broad.mit.edu	37	13	49281203	49281203	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr13:49281203G>C	uc010acx.1	+	6	933	c.250G>C	c.(250-252)GAT>CAT	p.D84H	CYSLTR2_uc010acy.1_Missense_Mutation_p.D84H|CYSLTR2_uc010acz.1_Missense_Mutation_p.D84H|CYSLTR2_uc010ada.1_Missense_Mutation_p.D84H|CYSLTR2_uc010adb.1_Missense_Mutation_p.D84H|CYSLTR2_uc010adc.1_Missense_Mutation_p.D84H|CYSLTR2_uc010add.1_Missense_Mutation_p.D84H|CYSLTR2_uc010acw.1_Missense_Mutation_p.D84H|CYSLTR2_uc001vck.2_Missense_Mutation_p.D84H	NM_020377	NP_065110	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	84	Helical; Name=2; (Potential).				immune response	integral to membrane|plasma membrane				lung(2)	2		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	GGCCATTTCAGATCTCCTGTT	0.443			NA											17	139					0	0	0.004007	0	0
SLITRK6	84189	broad.mit.edu	37	13	86369995	86369995	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr13:86369995C>T	uc001vll.1	-	2	1108	c.649G>A	c.(649-651)GAC>AAC	p.D217N	SLITRK6_uc010afe.1_5'UTR	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	217	Extracellular (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		CATTTGTTGTCCTCCAACTGA	0.413			NA											45	146					0	0	0.010771	0	0
DZIP1	22873	broad.mit.edu	37	13	96274626	96274626	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr13:96274626G>A	uc001vmk.2	-	9	1933	c.1081C>T	c.(1081-1083)CAT>TAT	p.H361Y	DZIP1_uc001vml.2_Missense_Mutation_p.H361Y	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	361					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			ATGACATTATGGAAATCCTGG	0.423			NA											17	141					0	0	0.004007	0	0
NALCN	259232	broad.mit.edu	37	13	101755531	101755531	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr13:101755531T>A	uc001vox.1	-	26	3238	c.3049A>T	c.(3049-3051)ATT>TTT	p.I1017F		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1017	Helical; Name=S5 of repeat III; (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ACCAAAAAAATTTCCTTGAAG	0.438			NA											22	205					0	0	0.014323	0	0
NYNRIN	57523	broad.mit.edu	37	14	24885288	24885288	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr14:24885288G>T	uc001wpf.3	+	9	4651	c.4333G>T	c.(4333-4335)GCC>TCC	p.A1445S		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1445					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						GGACACCCTGGCCAAGCAGGG	0.582			NA											10	55					9.70103e-10	1.48899e-09	0.008291	1	0
PAPLN	89932	broad.mit.edu	37	14	73725989	73725989	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr14:73725989A>G	uc010ttx.1	+	15	1884	c.1721A>G	c.(1720-1722)CAG>CGG	p.Q574R	PAPLN_uc001xnw.3_Missense_Mutation_p.Q547R|PAPLN_uc010arl.2_RNA|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Missense_Mutation_p.Q574R|PAPLN_uc010arm.2_5'Flank	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	574						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		TCCAGAGGCCAGTGGTGGGCA	0.647			NA											7	143					0	0	0.008291	0	0
FLRT2	23768	broad.mit.edu	37	14	86089492	86089492	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr14:86089492G>T	uc001xvr.2	+	2	2401	c.1634G>T	c.(1633-1635)GGC>GTC	p.G545V	FLRT2_uc010atd.2_Missense_Mutation_p.G545V	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	545	Helical; (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		CTGCTGGCGGGCTTGATCGGG	0.587			NA											11	88					4.36969e-10	6.74619e-10	0.016723	1	0
SERPINA12	145264	broad.mit.edu	37	14	94964180	94964180	+	Silent	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr14:94964180G>T	uc001ydj.2	-	3	1351	c.555C>A	c.(553-555)ACC>ACA	p.T185T		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	185					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		TTTTCCCATGGGTTTTTTGAC	0.373			NA											30	183					1.08312e-15	1.95852e-15	0.009535	1	0
SERPINA4	5267	broad.mit.edu	37	14	95034546	95034546	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr14:95034546G>T	uc001ydk.2	+	4	1070	c.1004G>T	c.(1003-1005)AGG>ATG	p.R335M	SERPINA4_uc010avd.2_Missense_Mutation_p.R372M|SERPINA4_uc001ydl.2_Missense_Mutation_p.R335M	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	335					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		ATTTTGCCCAGGCTGGGCTTC	0.458			NA											45	191					1.8453e-21	3.60858e-21	0.010771	1	0
MKRN3	7681	broad.mit.edu	37	15	23811566	23811566	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr15:23811566C>G	uc001ywh.3	+	1	1113	c.637C>G	c.(637-639)CGG>GGG	p.R213G	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.R213G	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	213						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GCAGCCCTACCGGGGCCGCTG	0.587			NA											5	33					0	0	0.001168	0	0
TRPM1	4308	broad.mit.edu	37	15	31362381	31362381	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr15:31362381A>T	uc001zfm.2	-	3	194	c.66T>A	c.(64-66)AGT>AGA	p.S22R	TRPM1_uc010azy.2_5'Flank|TRPM1_uc001zfl.2_5'Flank|TRPM1_uc001zfn.3_Missense_Mutation_p.S22R|uc010ubn.1_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	22	Extracellular (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TGGGTGTTGCACTTGGCAGAG	0.512			NA											54	455					0	0	0.01441	0	0
RYR3	6263	broad.mit.edu	37	15	33945030	33945030	+	Silent	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr15:33945030C>A	uc001zhi.2	+	32	4324	c.4254C>A	c.(4252-4254)GCC>GCA	p.A1418A	RYR3_uc010bar.2_Silent_p.A1418A	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1418	4 X approximate repeats.|B30.2/SPRY 3.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGGATCTGGCCATGGGCATGT	0.577			NA											10	63					1.76689e-08	2.5214e-08	0.006214	1	0
MGA	23269	broad.mit.edu	37	15	42042472	42042472	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr15:42042472G>T	uc010ucy.1	+	17	6848	c.6667G>T	c.(6667-6669)GAC>TAC	p.D2223Y	MGA_uc010ucz.1_Missense_Mutation_p.D2014Y|MGA_uc010uda.1_Missense_Mutation_p.D839Y|MGA_uc001zoi.2_Missense_Mutation_p.D437Y	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2184	Basic motif.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		AGGCATCTCTGACTTACTTGG	0.378			NA											24	170					6.21321e-17	1.15513e-16	0.016522	1	0
CHRNB4	1143	broad.mit.edu	37	15	78921890	78921890	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr15:78921890C>A	uc002bed.1	-	5	869	c.757G>T	c.(757-759)GTC>TTC	p.V253F	CHRNB4_uc002bee.1_Intron|CHRNB4_uc010blh.1_Missense_Mutation_p.V71F	NM_000750	NP_000741	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4	253	Helical; (Potential).				regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						AGGTAGAAGACGAGGATGGCC	0.552			NA											14	85					1.00905e-13	1.76416e-13	0.008871	1	0
KIAA1024	23251	broad.mit.edu	37	15	79750731	79750731	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr15:79750731G>A	uc002bew.1	+	2	2317	c.2242G>A	c.(2242-2244)GAG>AAG	p.E748K	KIAA1024_uc010unk.1_Missense_Mutation_p.E748K	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	748						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						CAATGAGGAGGAGATAAAAGA	0.468			NA											12	74					0	0	0.013537	0	0
IL16	3603	broad.mit.edu	37	15	81592014	81592015	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr15:81592014_81592015CC>AA	uc002bgh.3	+	14	2723_2724	c.2347_2348CC>AA	c.(2347-2349)CCT>AAT	p.P783N	IL16_uc010blq.1_Missense_Mutation_p.P737N|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.P825N|IL16_uc002bgg.2_Missense_Mutation_p.P783N|IL16_uc002bgi.1_Missense_Mutation_p.P173N|IL16_uc002bgj.2_Missense_Mutation_p.P277N|IL16_uc002bgk.2_Missense_Mutation_p.P82N|IL16_uc002bgl.1_Missense_Mutation_p.P82N|IL16_uc010unq.1_Missense_Mutation_p.P82N	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	783					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						GAAGAAAGGTCCTCCTGTGGCT	0.569			NA											8	83					0	0	0.004672	0	0
HDGFRP3	50810	broad.mit.edu	37	15	83826167	83826167	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr15:83826167C>A	uc002bjs.1	-	4	614	c.459G>T	c.(457-459)AAG>AAT	p.K153N		NM_016073	NP_057157	Q9Y3E1	HDGR3_HUMAN	hepatoma-derived growth factor, related protein	153					cell proliferation	nucleus	growth factor activity				0						TCTTAGTAACCTTTGAAGTAT	0.308			NA											10	90					0.00010058	0.000118014	0.013537	1	0
ADAMTSL3	57188	broad.mit.edu	37	15	84611369	84611369	+	Silent	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr15:84611369G>T	uc002bjz.3	+	18	2363	c.2139G>T	c.(2137-2139)GGG>GGT	p.G713G	ADAMTSL3_uc010bmt.1_Silent_p.G713G|ADAMTSL3_uc010bmu.1_Silent_p.G713G	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	713	TSP type-1 5.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			GCTCTTGGGGGCCCTGCTCAG	0.537			NA											12	107					6.72482e-11	1.0959e-10	0.003163	1	0
NOMO1	23420	broad.mit.edu	37	16	14982998	14982998	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr16:14982998G>T	uc002dcv.2	+	29	3436	c.3370G>T	c.(3370-3372)GAC>TAC	p.D1124Y		NM_014287	NP_055102	Q15155	NOMO1_HUMAN	nodal modulator 1 precursor	1124	Extracellular (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			ovary(1)	1						ATCCCAGTATGACTACATCTT	0.423			NA											44	369					3.40343e-31	7.07484e-31	0.01441	1	0
SMG1	23049	broad.mit.edu	37	16	18881188	18881188	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr16:18881188G>C	uc002dfm.2	-	19	2984	c.2621C>G	c.(2620-2622)TCT>TGT	p.S874C	SMG1_uc010bwb.2_Missense_Mutation_p.S734C	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	874	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						TGTTCTATGAGAGTTCCCATA	0.318			NA											6	41					0	0	0.00308	0	0
UMOD	7369	broad.mit.edu	37	16	20352502	20352502	+	Silent	SNP	C	C	G			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr16:20352502C>G	uc002dgz.2	-	7	1617	c.1488G>C	c.(1486-1488)CTG>CTC	p.L496L	UMOD_uc002dha.2_Silent_p.L496L|UMOD_uc002dhb.2_Silent_p.L529L	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	496	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						CAAATCGGGACAGGTCGCCCC	0.557			NA											4	49					0	0	0.014758	0	0
TNRC6A	27327	broad.mit.edu	37	16	24834793	24834793	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr16:24834793A>T	uc002dmm.2	+	25	5668	c.5554A>T	c.(5554-5556)AGT>TGT	p.S1852C	TNRC6A_uc010bxs.2_Missense_Mutation_p.S1599C|TNRC6A_uc002dmn.2_Missense_Mutation_p.S1550C|TNRC6A_uc002dmo.2_Missense_Mutation_p.S1491C|TNRC6A_uc002dmr.2_Missense_Mutation_p.S51C	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1852	Sufficient for interaction with EIF2C2.|RRM.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		TGAGTTTGCCAGTGAAGAGGA	0.577			NA											30	165					0	0	0.012213	0	0
CTCF	10664	broad.mit.edu	37	16	67662413	67662413	+	Silent	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr16:67662413G>T	uc002etl.2	+	9	1949	c.1659G>T	c.(1657-1659)GCG>GCT	p.A553A	CTCF_uc010cek.2_Silent_p.A225A|CTCF_uc002etm.1_Silent_p.A42A	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	553					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		TCGTCCCTGCGGCTTTTGTCT	0.483	Colon(175;1200 1966 6945 23069 27405)		NA											22	157					1.55469e-16	2.85027e-16	0.01892	1	0
CTCF	10664	broad.mit.edu	37	16	67663408	67663408	+	Silent	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr16:67663408C>T	uc002etl.2	+	10	2099	c.1809C>T	c.(1807-1809)CGC>CGT	p.R603R	CTCF_uc010cek.2_Silent_p.R275R|CTCF_uc002etm.1_Silent_p.R92R	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	603					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		GAAAGATGCGCTCTAAGAAAG	0.448	Colon(175;1200 1966 6945 23069 27405)		NA											5	97					0	0	0.001168	0	0
DNAH9	1770	broad.mit.edu	37	17	11656186	11656186	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr17:11656186T>A	uc002gne.2	+	33	6715	c.6647T>A	c.(6646-6648)ATC>AAC	p.I2216N	DNAH9_uc010coo.2_Missense_Mutation_p.I1510N	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2216	AAA 2 (By similarity).			I -> T (in Ref. 4; BAA21573).	cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTTGCCAACATCACCCATGAT	0.413			NA											18	99					0	0	0.012319	0	0
FLOT2	2319	broad.mit.edu	37	17	27209238	27209238	+	Silent	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr17:27209238C>T	uc002hdc.2	-	7	720	c.597G>A	c.(595-597)AAG>AAA	p.K199K		NM_004475	NP_004466	Q14254	FLOT2_HUMAN	flotillin 2	199					cell adhesion|epidermis development	cell surface|endocytic vesicle|endosome|membrane fraction					0	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;3.26e-06)|all cancers(11;1.76e-05)|BRCA - Breast invasive adenocarcinoma(11;0.00015)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			CCAGCATCTCCTTCTTGCACT	0.522			NA											20	158					0	0	0.007413	0	0
CCDC56	28958	broad.mit.edu	37	17	40948054	40948054	+	Silent	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr17:40948054G>A	uc010wgz.1	-	3	481	c.204C>T	c.(202-204)CTC>CTT	p.L68L	WNK4_uc002ibj.2_Intron|WNK4_uc010wgx.1_Intron|CNTD1_uc002ibm.3_5'Flank|CNTD1_uc010wha.1_5'Flank			Q9Y2R0	CCD56_HUMAN	SubName: Full=cDNA FLJ50764;	Error:Variant_position_missing_in_Q9Y2R0_after_alignment						integral to membrane					0		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0741)		CGGCAGAAGTGAGTCTCGGGA	0.567			NA											14	63					0	0	0.016723	0	0
UTP18	51096	broad.mit.edu	37	17	49357467	49357467	+	Splice_Site	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr17:49357467G>T	uc002its.2	+	8	1162	c.1113_splice	c.e8+1	p.K371_splice		NM_016001	NP_057085	Q9Y5J1	UTP18_HUMAN	UTP18, small subunit processome component						rRNA processing	nucleolus					0			BRCA - Breast invasive adenocarcinoma(22;2.09e-07)			AGCAATGAAGGTAAAGCATTA	0.413			NA											5	53					0.00116845	0.00130156	0.001168	1	0
ANAPC11	51529	broad.mit.edu	37	17	79857813	79857813	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr17:79857813G>T	uc002kbv.1	+	4	342	c.127G>T	c.(127-129)GAC>TAC	p.D43Y	ANAPC11_uc002kbw.1_Missense_Mutation_p.D43Y|ANAPC11_uc002kbx.1_Missense_Mutation_p.D43Y|ANAPC11_uc002kby.1_Missense_Mutation_p.R143L|ANAPC11_uc002kbz.1_Missense_Mutation_p.D43Y|ANAPC11_uc002kca.1_Missense_Mutation_p.D43Y|ANAPC11_uc002kcb.1_Missense_Mutation_p.D43Y|ANAPC11_uc002kcc.1_Missense_Mutation_p.D43Y|ANAPC11_uc010dih.1_Missense_Mutation_p.D43Y|NPB_uc002kcd.2_5'Flank	NM_016476	NP_057560	Q9NYG5	APC11_HUMAN	APC11 anaphase promoting complex subunit 11	43	RING-type.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	zinc ion binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			GCCCGGCGACGACTGCCCGCT	0.637			NA											4	30					1.23904e-05	1.52143e-05	0.014758	1	0
MC5R	4161	broad.mit.edu	37	18	13826463	13826463	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr18:13826463C>A	uc010xaf.1	+	1	699	c.699C>A	c.(697-699)AGC>AGA	p.S233R		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	233	Cytoplasmic (Potential).			ALPGASSARQRTSM -> LCPGPALRGRGPAW (in Ref. 1).	G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						AGAGGACCAGCATGCAGGGCG	0.612			NA											40	181					1.69901e-12	2.8938e-12	0.005524	1	0
NETO1	81832	broad.mit.edu	37	18	70417550	70417550	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr18:70417550C>G	uc002lkw.2	-	9	1572	c.1288G>C	c.(1288-1290)GAC>CAC	p.D430H	NETO1_uc002lkx.1_Missense_Mutation_p.D429H|NETO1_uc002lky.1_Missense_Mutation_p.D430H	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	430	Cytoplasmic (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		CAGTGATGGTCATGAATGCAT	0.493			NA											13	61					0	0	0.013537	0	0
MUC16	94025	broad.mit.edu	37	19	9046706	9046706	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr19:9046706G>T	uc002mkp.2	-	5	35129	c.34925C>A	c.(34924-34926)ACT>AAT	p.T11642N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11644	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGCTGTACTAGTGTCTGTTGC	0.517			NA											20	107					1.28384e-07	1.72047e-07	0.012319	1	0
MUC16	94025	broad.mit.edu	37	19	9061615	9061615	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr19:9061615G>T	uc002mkp.2	-	3	26035	c.25831C>A	c.(25831-25833)CCT>ACT	p.P8611T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8613	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGGTTTCAGGTTCTGAGCTT	0.483			NA											11	82					0.000978159	0.00109887	0.010729	1	0
MUC16	94025	broad.mit.edu	37	19	9089295	9089295	+	Silent	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr19:9089295G>T	uc002mkp.2	-	1	2724	c.2520C>A	c.(2518-2520)CTC>CTA	p.L840L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	840	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGACACTTGGGAGGCTGAGAG	0.468			NA											16	143					4.35082e-09	6.48935e-09	0.010504	1	0
KEAP1	9817	broad.mit.edu	37	19	10610279	10610279	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr19:10610279G>A	uc002moq.1	-	2	587	c.431C>T	c.(430-432)TCC>TTC	p.S144F	KEAP1_uc002mor.1_Missense_Mutation_p.S144F	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	144	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CATGGAGATGGAGGCCGTGTA	0.587			NA											11	51					0	0	0.008291	0	0
CEACAM7	1087	broad.mit.edu	37	19	42191008	42191009	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr19:42191008_42191009CC>AA	uc002ori.1	-	2	210_211	c.208_209GG>TT	c.(208-210)GGG>TTG	p.G70L	CEACAM7_uc010ehx.2_Missense_Mutation_p.G70L|CEACAM7_uc010ehy.1_Missense_Mutation_p.G70L	NM_006890	NP_008821	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion	70	Ig-like V-type.					anchored to membrane|integral to membrane|plasma membrane				ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)		CACCCTTTCCCCTTTGTACCAG	0.441			NA											18	147					0	0	0.004672	0	0
ZNF766	90321	broad.mit.edu	37	19	52794388	52794388	+	Silent	SNP	T	T	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr19:52794388T>C	uc002pyr.1	+	4	1387	c.1344T>C	c.(1342-1344)TTT>TTC	p.F448F	ZNF766_uc002pys.1_3'UTR|ZNF766_uc002pyt.1_Intron	NM_001010851	NP_001010851	Q5HY98	ZN766_HUMAN	zinc finger protein 766	448	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00236)|OV - Ovarian serous cystadenocarcinoma(262;0.00871)		GTAAGGTCTTTAGGCACAGTT	0.413			NA											7	191					0	0	0.001984	0	0
NLRP8	126205	broad.mit.edu	37	19	56467169	56467169	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr19:56467169G>T	uc002qmh.2	+	3	1816	c.1745G>T	c.(1744-1746)GGT>GTT	p.G582V	NLRP8_uc010etg.2_Missense_Mutation_p.G582V	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	582						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GTGTCTTTCGGTAATAAGAGG	0.478			NA											12	44					1.08611e-07	1.478e-07	0.010729	1	0
C2orf39	92749	broad.mit.edu	37	2	26667141	26667141	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr2:26667141G>T	uc002rhg.2	+	9	1154	c.1080G>T	c.(1078-1080)AAG>AAT	p.K360N	C2orf39_uc010eym.1_RNA	NM_145038	NP_659475	Q96MC2	CC164_HUMAN	hypothetical protein LOC92749	360	Potential.										0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGCAAATAAAGCAGTTTCAGG	0.408			NA											11	95					0.00829132	0.00886198	0.008291	1	0
LTBP1	4052	broad.mit.edu	37	2	33488394	33488394	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr2:33488394T>A	uc002ros.2	+	15	2555	c.2555T>A	c.(2554-2556)GTT>GAT	p.V852D	LTBP1_uc002rot.2_Missense_Mutation_p.V526D|LTBP1_uc002rou.2_Missense_Mutation_p.V525D|LTBP1_uc002rov.2_Missense_Mutation_p.V472D|LTBP1_uc010ymz.1_Missense_Mutation_p.V525D|LTBP1_uc010yna.1_Missense_Mutation_p.V472D	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	851					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CCTGTGCCTGTTGAAGTAGCT	0.403			NA											27	203					0	0	0.010818	0	0
CCDC88A	55704	broad.mit.edu	37	2	55563913	55563913	+	Silent	SNP	A	A	G			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr2:55563913A>G	uc002ryv.2	-	14	2402	c.1560T>C	c.(1558-1560)AGT>AGC	p.S520S	CCDC88A_uc010yoz.1_Silent_p.S520S|CCDC88A_uc010ypa.1_Silent_p.S520S|CCDC88A_uc010ypb.1_Silent_p.S422S|CCDC88A_uc002ryu.2_5'Flank|CCDC88A_uc002ryw.2_5'Flank	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	520	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						AATTCTGAAGACTTTGCTTTT	0.318			NA											11	66					0	0	0.008291	0	0
ALMS1P	200420	broad.mit.edu	37	2	73898278	73898278	+	Splice_Site	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr2:73898278G>T	uc010yrl.1	+	2	307	c.-214_splice	c.e2+1			NR_003683				RecName: Full=Putative ALMS1-like protein;												0						ACACAAGCAGGTAATTACTTG	0.244			NA											23	165					7.87624e-14	1.38622e-13	0.016522	1	0
SNRNP200	23020	broad.mit.edu	37	2	96954407	96954407	+	Silent	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr2:96954407G>A	uc002svu.2	-	24	3338	c.3252C>T	c.(3250-3252)GTC>GTT	p.V1084V	SNRNP200_uc002svw.1_Silent_p.V156V	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	1084	SEC63 1.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						TCACCTGTGTGACATACACCA	0.517			NA											12	83					0	0	0.016723	0	0
GALNT13	114805	broad.mit.edu	37	2	155306968	155306968	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr2:155306968C>A	uc002tyr.3	+	13	2143	c.1576C>A	c.(1576-1578)CCT>ACT	p.P526T	GALNT13_uc002tyt.3_3'UTR|GALNT13_uc010fod.2_3'UTR|uc002tyu.1_Intron	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	526	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TCTCGATGAACCTTCTGAAGA	0.438			NA											15	99					9.16793e-09	1.3372e-08	0.00499	1	0
SCN3A	6328	broad.mit.edu	37	2	165969467	165969467	+	Silent	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr2:165969467G>T	uc002ucx.2	-	21	4263	c.3771C>A	c.(3769-3771)CTC>CTA	p.L1257L	SCN3A_uc002ucy.2_Silent_p.L1208L|SCN3A_uc002ucz.2_Silent_p.L1208L|SCN3A_uc002uda.1_Silent_p.L1077L|SCN3A_uc002udb.1_Silent_p.L1077L	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1257	Helical; Name=S2 of repeat III; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CAACCCATTTGAGAAGCATTT	0.323			NA											72	395					4.98926e-31	1.02903e-30	0.01441	1	0
IHH	3549	broad.mit.edu	37	2	219922285	219922285	+	Silent	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr2:219922285G>A	uc002vjo.1	-	2	447	c.447C>T	c.(445-447)CGC>CGT	p.R149R		NM_002181	NP_002172	Q14623	IHH_HUMAN	Indian hedgehog homolog precursor	149					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)	1		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGTCCACCGCGCGGCCCTCAT	0.617			NA											7	31					0	0	0.001984	0	0
PLCB1	23236	broad.mit.edu	37	20	8862361	8862361	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr20:8862361G>T	uc002wnb.2	+	32	3519	c.3516G>T	c.(3514-3516)AAG>AAT	p.K1172N	PLCB1_uc002wna.2_3'UTR	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	1172					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						TGAAAGGAAAGATCAGTGAAG	0.517			NA											42	245					1.00001e-27	2.03078e-27	0.009718	1	0
C20orf103	24141	broad.mit.edu	37	20	9496207	9496207	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr20:9496207C>A	uc002wni.1	+	2	401	c.172C>A	c.(172-174)CTC>ATC	p.L58I	C20orf103_uc010zrc.1_Missense_Mutation_p.L58I	NM_012261	NP_036393	Q9UJQ1	CT103_HUMAN	chromosome 20 open reading frame 103 precursor	58	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|lung(1)|breast(1)	3			COAD - Colon adenocarcinoma(9;0.194)			GACGACGTGTCTCATGGCAGA	0.463			NA											22	126					7.41877e-09	1.08809e-08	0.012319	1	0
PAK7	57144	broad.mit.edu	37	20	9561009	9561009	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr20:9561009C>A	uc002wnl.2	-	5	1318	c.773G>T	c.(772-774)GGA>GTA	p.G258V	PAK7_uc002wnk.2_Missense_Mutation_p.G258V|PAK7_uc002wnj.2_Missense_Mutation_p.G258V|PAK7_uc010gby.1_Missense_Mutation_p.G258V	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	258	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			CAGGCTGGGTCCCCATTCACT	0.562			NA											10	106					0.00829132	0.00886198	0.008291	1	0
ANKRD5	63926	broad.mit.edu	37	20	10030593	10030593	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr20:10030593A>G	uc002wno.2	+	7	1769	c.1376A>G	c.(1375-1377)TAC>TGC	p.Y459C	uc002wnn.1_Intron|ANKRD5_uc002wnp.2_Missense_Mutation_p.Y459C|ANKRD5_uc010gbz.2_Missense_Mutation_p.Y270C	NM_022096	NP_071379	Q9NU02	ANKR5_HUMAN	ankyrin repeat domain protein 5	459							calcium ion binding			ovary(1)|breast(1)	2						ATTGAGACCTACAAGAATGTC	0.463			NA											21	155					0	0	0.008871	0	0
PAX1	5075	broad.mit.edu	37	20	21695369	21695369	+	Silent	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr20:21695369C>A	uc002wsj.2	+	5	1587	c.1533C>A	c.(1531-1533)CCC>CCA	p.P511P	PAX1_uc010zsl.1_3'UTR|PAX1_uc010zsm.1_3'UTR	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	511					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						AGGCCCAGCCCTGCCTCTGGC	0.652			NA											5	30					0.000602214	0.000679421	0.014758	1	0
EDEM2	55741	broad.mit.edu	37	20	33714148	33714148	+	Missense_Mutation	SNP	C	C	A	rs148170838	byFrequency	TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr20:33714148C>A	uc002xbo.2	-	8	975	c.875G>T	c.(874-876)CGC>CTC	p.R292L	EDEM2_uc010zuv.1_Missense_Mutation_p.R251L|EDEM2_uc010zus.1_Missense_Mutation_p.R71L|EDEM2_uc002xbq.2_Missense_Mutation_p.R255L|EDEM2_uc010zut.1_Missense_Mutation_p.R251L|EDEM2_uc002xbp.2_Missense_Mutation_p.R140L|EDEM2_uc002xbn.2_Missense_Mutation_p.R140L|EDEM2_uc002xbr.2_RNA|EDEM2_uc010zuu.1_Missense_Mutation_p.R16L	NM_018217	NP_060687	Q9BV94	EDEM2_HUMAN	ER degradation enhancer, mannosidase alpha-like	292					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00936)			GTCATCGAAGCGGGTGTAGTT	0.532	Esophageal Squamous(51;906 1021 24535 36410 39145)		NA											19	116					8.10497e-08	1.13815e-07	0.010504	1	0
PHACTR3	116154	broad.mit.edu	37	20	58342383	58342384	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr20:58342383_58342384CC>AA	uc002yau.2	+	5	1151_1152	c.684_685CC>AA	c.(682-687)CTCCCC>CTAACC	p.P229T	PHACTR3_uc002yat.2_Missense_Mutation_p.P226T|PHACTR3_uc010zzw.1_Missense_Mutation_p.P188T|PHACTR3_uc002yav.2_Missense_Mutation_p.P188T|PHACTR3_uc002yaw.2_Missense_Mutation_p.P188T|PHACTR3_uc002yax.2_Intron	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	229	Pro-rich.					nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			TGGGCCAGCTCCCCAGCCCCCC	0.609			NA											9	38					0	0	0.004672	0	0
TAF4	6874	broad.mit.edu	37	20	60575248	60575248	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr20:60575248G>A	uc002ybs.2	-	11	2719	c.2719C>T	c.(2719-2721)CAA>TAA	p.Q907*		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	907					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			AGCCTTTGTTGCGTGGCATGT	0.373			NA											19	113					0	0	0.008871	0	0
C20orf151	140893	broad.mit.edu	37	20	60990964	60990964	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr20:60990964C>T	uc002ycw.1	-	7	581	c.424G>A	c.(424-426)GAC>AAC	p.D142N		NM_080833	NP_543023	Q8NC74	CT151_HUMAN	hypothetical protein LOC140893	142											0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;6.43e-06)			GAGGGGGGGTCCGAGGTGCCC	0.662			NA											3	10					0	0	0.004672	0	0
SEZ6L	23544	broad.mit.edu	37	22	26690378	26690378	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr22:26690378G>T	uc003acb.2	+	3	1112	c.956G>T	c.(955-957)GGG>GTG	p.G319V	SEZ6L_uc003acc.2_Missense_Mutation_p.G319V|SEZ6L_uc011akc.1_Missense_Mutation_p.G319V|SEZ6L_uc003acd.2_Missense_Mutation_p.G319V|SEZ6L_uc011akd.1_Missense_Mutation_p.G319V|SEZ6L_uc003ace.2_Missense_Mutation_p.G319V|SEZ6L_uc003acf.1_Missense_Mutation_p.G92V|SEZ6L_uc010gvc.1_Missense_Mutation_p.G92V	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	319	CUB 1.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						ACTGGCTATGGGGTGGAGCTC	0.537			NA											19	115					1.45105e-14	2.58836e-14	0.006122	1	0
SEZ6L	23544	broad.mit.edu	37	22	26769422	26769422	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr22:26769422C>T	uc003acb.2	+	14	2956	c.2800C>T	c.(2800-2802)CAA>TAA	p.Q934*	SEZ6L_uc003acc.2_Nonsense_Mutation_p.Q934*|SEZ6L_uc011akc.1_Intron|SEZ6L_uc003acd.2_Intron|SEZ6L_uc011akd.1_Intron|SEZ6L_uc003ace.2_Intron|SEZ6L_uc003acf.1_Nonsense_Mutation_p.Q707*|SEZ6L_uc010gvc.1_Intron|SEZ6L_uc011ake.1_Intron	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	934	Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						TTCAGTTAATCAAGACAGTTT	0.353			NA											7	82					0	0	0.00308	0	0
EFCAB6	64800	broad.mit.edu	37	22	44028081	44028081	+	Silent	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr22:44028081C>T	uc003bdy.1	-	19	2351	c.2136G>A	c.(2134-2136)CAG>CAA	p.Q712Q	EFCAB6_uc003bdz.1_Silent_p.Q560Q|EFCAB6_uc010gzi.1_Silent_p.Q560Q|EFCAB6_uc010gzj.1_Silent_p.Q10Q|EFCAB6_uc010gzk.1_RNA	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	712					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				GAGTTGGAGGCTGCGGCGGAG	0.478			NA											13	101					0	0	0.013537	0	0
WNT7B	7477	broad.mit.edu	37	22	46319087	46319087	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr22:46319087G>C	uc003bgo.2	-	4	1073	c.699C>G	c.(697-699)AAC>AAG	p.N233K	WNT7B_uc010haa.2_Missense_Mutation_p.N237K	NM_058238	NP_478679	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family,	233					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			lung(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		GCACGGCCGCGTTGTACTTCT	0.642			NA											4	28					0	0	0.006214	0	0
NUP210	23225	broad.mit.edu	37	3	13427851	13427851	+	Silent	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr3:13427851C>A	uc003bxv.1	-	6	824	c.741G>T	c.(739-741)CCG>CCT	p.P247P		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	247	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					CGTCATAGGCCGGGTTCAGAA	0.493			NA											25	157					3.7963e-18	7.21025e-18	0.01892	1	0
ARPP21	10777	broad.mit.edu	37	3	35835224	35835224	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr3:35835224C>A	uc003cgb.2	+	20	2477	c.2213C>A	c.(2212-2214)CCC>CAC	p.P738H	ARPP21_uc003cga.2_Missense_Mutation_p.P719H|ARPP21_uc011axy.1_Missense_Mutation_p.P739H|ARPP21_uc003cgf.2_Missense_Mutation_p.P574H|ARPP21_uc003cgg.2_Missense_Mutation_p.P261H	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	738	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						CAAGGACTGCCCCAGCAGTCA	0.468			NA											9	67					1.12685e-05	1.39013e-05	0.004482	1	0
HHATL	57467	broad.mit.edu	37	3	42739015	42739015	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr3:42739015G>T	uc003clw.2	-	8	997	c.850C>A	c.(850-852)CCA>ACA	p.P284T	HHATL_uc003clx.2_Missense_Mutation_p.P284T	NM_020707	NP_065758	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	284					negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				ovary(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.215)		GCACTGTCTGGGAGGCGGTTG	0.617			NA											11	103					1.67942e-08	2.4096e-08	0.006122	1	0
KIF9	64147	broad.mit.edu	37	3	47288896	47288896	+	Silent	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr3:47288896C>T	uc010hjp.2	-	13	1804	c.1200G>A	c.(1198-1200)CGG>CGA	p.R400R	KIF9_uc003cqx.2_Silent_p.R400R|KIF9_uc003cqy.2_Silent_p.R400R|KIF9_uc011bat.1_RNA|KIF9_uc011bau.1_RNA	NM_001134878	NP_001128350	Q9HAQ2	KIF9_HUMAN	kinesin family member 9 isoform 2	400					blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		CCAGGTACCTCCGCACCTGGG	0.557	Colon(44;962 1147 15977 24541)		NA											14	121					0	0	0.003163	0	0
PLXNB1	5364	broad.mit.edu	37	3	48457786	48457786	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr3:48457786C>A	uc003csw.2	-	17	3719	c.3449G>T	c.(3448-3450)CGT>CTT	p.R1150L	PLXNB1_uc003cst.2_5'Flank|PLXNB1_uc003csu.2_Missense_Mutation_p.R967L|PLXNB1_uc003csx.2_Missense_Mutation_p.R1150L|PLXNB1_uc010hjx.1_RNA|PLXNB1_uc003csy.1_5'UTR	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	1150	IPT/TIG 1.|Extracellular (Potential).				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TGAGACACCACGTCCTCTTCC	0.667			NA											12	60					1.5842e-08	2.29796e-08	0.016723	1	0
PHF7	51533	broad.mit.edu	37	3	52455671	52455671	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr3:52455671C>T	uc003ddy.2	+	8	1387	c.581C>T	c.(580-582)GCC>GTC	p.A194V	PHF7_uc003ddz.2_Missense_Mutation_p.A194V	NM_016483	NP_057567	Q9BWX1	PHF7_HUMAN	PHD finger protein 7 isoform 1	194	RING-type; degenerate.					nucleus	zinc ion binding			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;1.71e-05)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)|OV - Ovarian serous cystadenocarcinoma(275;0.0275)		CAGAAATATGCCCACACATCA	0.423			NA											4	99					0	0	0.009096	0	0
FLNB	2317	broad.mit.edu	37	3	58110122	58110122	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr3:58110122G>T	uc003djj.2	+	22	3953	c.3788G>T	c.(3787-3789)GGT>GTT	p.G1263V	FLNB_uc010hne.2_Missense_Mutation_p.G1263V|FLNB_uc003djk.2_Missense_Mutation_p.G1263V|FLNB_uc010hnf.2_Missense_Mutation_p.G1263V|FLNB_uc003djl.2_Missense_Mutation_p.G1094V|FLNB_uc003djm.2_Missense_Mutation_p.G1094V	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1263	Filamin 11.|Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CAGGTTGGGGGTGACCACATC	0.572			NA											19	84					5.3912e-06	6.71357e-06	0.006122	1	0
BOC	91653	broad.mit.edu	37	3	112993283	112993283	+	Silent	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr3:112993283C>A	uc003dzx.2	+	9	1917	c.1296C>A	c.(1294-1296)CCC>CCA	p.P432P	BOC_uc003dzy.2_Silent_p.P432P|BOC_uc003dzz.2_Silent_p.P432P|BOC_uc003eab.2_Silent_p.P133P	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	432	Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			CTGTATCACCCTCCAAACTCG	0.607			NA											7	75					1.06961e-07	1.478e-07	0.00308	1	0
POLQ	10721	broad.mit.edu	37	3	121207151	121207151	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr3:121207151C>G	uc003eee.3	-	16	4756	c.4627G>C	c.(4627-4629)GAT>CAT	p.D1543H	POLQ_uc003eed.2_Missense_Mutation_p.D715H	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1543					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TGGTGGGTATCTTGATTCTCA	0.338	Pancreas(152;907 1925 26081 31236 36904)		NA						DNA_polymerases_(catalytic_subunits)					5	130					0	0	0.014758	0	0
CASR	846	broad.mit.edu	37	3	122002991	122002991	+	Silent	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr3:122002991C>A	uc003eev.3	+	7	2562	c.2190C>A	c.(2188-2190)CTC>CTA	p.L730L	CASR_uc003eew.3_Silent_p.L740L	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	730	Helical; Name=4; (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TGGTTTTCCTCTGCACCTTCA	0.557			NA											8	61					0.00307968	0.00335965	0.00308	1	0
COL6A6	131873	broad.mit.edu	37	3	130285781	130285781	+	Silent	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr3:130285781C>A	uc010htl.2	+	4	1549	c.1518C>A	c.(1516-1518)ATC>ATA	p.I506I		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	506	VWFA 3.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TTGAGAATATCAGGCAGATGG	0.473			NA											24	104					2.89027e-11	4.76894e-11	0.014323	1	0
NEK11	79858	broad.mit.edu	37	3	130881250	130881250	+	Splice_Site	SNP	A	A	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr3:130881250A>T	uc003eny.2	+	11	1289	c.963_splice	c.e11-2	p.M321_splice	NEK11_uc003enx.2_Splice_Site_p.M321_splice|NEK11_uc003eoa.2_Splice_Site_p.M321_splice|NEK11_uc003enz.2_Splice_Site_p.M139_splice|NEK11_uc010htn.2_Splice_Site|NEK11_uc011blk.1_Splice_Site_p.M173_splice|NEK11_uc011bll.1_Splice_Site_p.W216_splice|NEK11_uc011blm.1_Splice_Site_p.M321_splice	NM_024800	NP_079076	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11 isoform 1						cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(4)|stomach(1)|central_nervous_system(1)	6						TGTTATTTATAGGCAAAAAAG	0.413			NA											63	359					0	0	0.01441	0	0
GK5	256356	broad.mit.edu	37	3	141900397	141900397	+	Silent	SNP	T	T	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr3:141900397T>C	uc003euq.1	-	11	1085	c.954A>G	c.(952-954)CCA>CCG	p.P318P	GK5_uc003eup.1_Silent_p.P39P|GK5_uc010hus.1_RNA	NM_001039547	NP_001034636	Q6ZS86	GLPK5_HUMAN	glycerol kinase 5 (putative)	318					glycerol metabolic process		ATP binding|glycerol kinase activity				0						ACCCAATTAATGGATAAAAGC	0.363			NA											12	89					0	0	0.010729	0	0
SLC9A9	285195	broad.mit.edu	37	3	142985602	142985602	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr3:142985602C>A	uc003evn.2	-	16	2062	c.1880G>T	c.(1879-1881)GGC>GTC	p.G627V		NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	627					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						GCCTCCCAGGCCGAGGTCTCC	0.498			NA											25	127					9.04412e-07	1.15905e-06	0.004656	1	0
SERPINI2	5276	broad.mit.edu	37	3	167164213	167164213	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr3:167164213G>T	uc003fer.1	-	7	1166	c.1108C>A	c.(1108-1110)CCA>ACA	p.P370T	SERPINI2_uc003fes.1_Missense_Mutation_p.P380T|SERPINI2_uc003fet.1_Missense_Mutation_p.P370T	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	370					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						AACAGAAATGGATGATTTGCT	0.333			NA											18	182					3.32936e-07	4.41684e-07	0.006122	1	0
MECOM	2122	broad.mit.edu	37	3	168812877	168812877	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr3:168812877A>T	uc003ffi.3	-	12	2711	c.2442T>A	c.(2440-2442)AAT>AAA	p.N814K	MECOM_uc010hwk.1_Missense_Mutation_p.N828K|MECOM_uc003ffj.3_Missense_Mutation_p.N879K|MECOM_uc011bpi.1_Missense_Mutation_p.N806K|MECOM_uc003ffn.3_Missense_Mutation_p.N814K|MECOM_uc003ffk.2_Missense_Mutation_p.N805K|MECOM_uc003ffl.2_Missense_Mutation_p.N965K|MECOM_uc011bpj.1_Missense_Mutation_p.N1002K|MECOM_uc011bpk.1_Missense_Mutation_p.N804K	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	814					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						ACATGTTCCCATTCTCATGTT	0.323			NA											12	88					0	0	0.016723	0	0
BEND4	389206	broad.mit.edu	37	4	42127651	42127651	+	Silent	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr4:42127651C>T	uc003gwn.2	-	4	1675	c.1095G>A	c.(1093-1095)CTG>CTA	p.L365L	BEND4_uc003gwm.2_Silent_p.L365L|BEND4_uc011byy.1_Silent_p.L365L	NM_207406	NP_997289	Q6ZU67	BEND4_HUMAN	BEN domain containing 4 isoform a	365											0						TGTGGTGCTGCAGAACCATCT	0.443			NA											5	31					0	0	0.014758	0	0
CSN2	1447	broad.mit.edu	37	4	70823356	70823356	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr4:70823356G>C	uc003hes.3	-	5	324	c.311C>G	c.(310-312)GCT>GGT	p.A104G	CSN2_uc003het.3_Missense_Mutation_p.A103G	NM_001891	NP_001882	P05814	CASB_HUMAN	casein beta precursor	104					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity				0						AGTGTCTTTAGCTTTAGGGAC	0.463			NA											16	123					0	0	0.007413	0	0
NPNT	255743	broad.mit.edu	37	4	106863785	106863785	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr4:106863785G>C	uc003hya.2	+	8	1290	c.1085G>C	c.(1084-1086)AGT>ACT	p.S362T	NPNT_uc011cfc.1_Missense_Mutation_p.S379T|NPNT_uc011cfd.1_Missense_Mutation_p.S392T|NPNT_uc011cfe.1_Missense_Mutation_p.S392T|NPNT_uc010ilt.1_Missense_Mutation_p.S362T|NPNT_uc011cff.1_Missense_Mutation_p.S362T|NPNT_uc010ilu.1_Missense_Mutation_p.S258T	NM_001033047	NP_001028219	Q6UXI9	NPNT_HUMAN	nephronectin precursor	362	Pro-rich.				cell differentiation	membrane	calcium ion binding			skin(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		CCAGCTGCCAGTACACCTCCA	0.512			NA											7	92					0	0	0.006214	0	0
FAT4	79633	broad.mit.edu	37	4	126240206	126240206	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr4:126240206C>A	uc003ifj.3	+	1	2640	c.2640C>A	c.(2638-2640)AAC>AAA	p.N880K		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	880	Extracellular (Potential).|Cadherin 8.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTATGGTTAACATAACAGTTA	0.448			NA											12	67					5.50884e-06	6.82785e-06	0.013537	1	0
RNF150	57484	broad.mit.edu	37	4	141888839	141888839	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr4:141888839C>A	uc003iio.1	-	2	1327	c.673G>T	c.(673-675)GCA>TCA	p.A225S	RNF150_uc010iok.1_Intron|RNF150_uc003iip.1_Missense_Mutation_p.A225S	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	225	Helical; (Potential).					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					ACGAGCCATGCGAGGGAAATG	0.423			NA											19	119					1.33834e-09	2.03058e-09	0.007413	1	0
TTC29	83894	broad.mit.edu	37	4	147796051	147796051	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr4:147796051C>T	uc003ikw.3	-	7	843	c.616G>A	c.(616-618)GAA>AAA	p.E206K	TTC29_uc010ipc.2_RNA|TTC29_uc003ikx.3_Missense_Mutation_p.E232K|TTC29_uc010ipd.1_Missense_Mutation_p.E206K	NM_031956	NP_114162	Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	206	TPR 1.						binding				0	all_hematologic(180;0.151)					TGGAATGCTTCATAATGCTCA	0.448			NA											6	38					0	0	0.008291	0	0
IRF2	3660	broad.mit.edu	37	4	185310048	185310048	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr4:185310048C>A	uc003iwf.3	-	9	1114	c.914G>T	c.(913-915)TGG>TTG	p.W305L		NM_002199	NP_002190	P14316	IRF2_HUMAN	interferon regulatory factor 2	305					blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		AAAAGGGGGCCAGGAGCTGTT	0.592			NA											19	120					5.35267e-07	6.99556e-07	0.007413	1	0
SDHAP3	728609	broad.mit.edu	37	5	1593386	1593386	+	Missense_Mutation	SNP	A	A	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr5:1593386A>C	uc010itg.1	-	2	151	c.74T>G	c.(73-75)GTG>GGG	p.V25G	SDHAP3_uc011cme.1_RNA					Homo sapiens cDNA clone IMAGE:40127561.												0						CTGGCCATTCACGTGCCTCAG	0.597			NA											3	67					0	0	0.014758	0	0
PRLR	5618	broad.mit.edu	37	5	35072726	35072726	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr5:35072726G>T	uc003jjm.2	-	6	1024	c.494C>A	c.(493-495)ACG>AAG	p.T165K	PRLR_uc003jjg.1_Missense_Mutation_p.T165K|PRLR_uc003jjh.1_Missense_Mutation_p.T165K|PRLR_uc003jji.1_Missense_Mutation_p.T94K|PRLR_uc003jjj.1_Missense_Mutation_p.T165K|PRLR_uc003jjk.1_Missense_Mutation_p.T94K|PRLR_uc003jjl.3_Missense_Mutation_p.T64K|PRLR_uc010iuw.1_Missense_Mutation_p.T94K	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	165	Fibronectin type-III 2.|Extracellular (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	ATACAGGAGCGTGAACCAACC	0.448			NA											19	168					4.63292e-17	8.67441e-17	0.008871	1	0
ANKRD55	79722	broad.mit.edu	37	5	55412488	55412488	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr5:55412488A>T	uc003jqu.2	-	9	1071	c.919T>A	c.(919-921)TAC>AAC	p.Y307N	ANKRD55_uc003jqt.2_Missense_Mutation_p.Y19N	NM_024669	NP_078945	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55 isoform 1	306	ANK 9.									skin(1)	1		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				TGACCGCAGTACAGGGCATAG	0.507			NA											25	133					0	0	0.00632	0	0
ANKRD55	79722	broad.mit.edu	37	5	55439661	55439661	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr5:55439661T>A	uc003jqu.2	-	7	731	c.579A>T	c.(577-579)AAA>AAT	p.K193N		NM_024669	NP_078945	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55 isoform 1	192										skin(1)	1		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				TTTTAAAGTCTTTATCCACAA	0.502			NA											50	301					0	0	0.01441	0	0
IQGAP2	10788	broad.mit.edu	37	5	75989204	75989204	+	Silent	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr5:75989204G>T	uc003kek.2	+	31	4152	c.3930G>T	c.(3928-3930)GTG>GTT	p.V1310V	IQGAP2_uc011csv.1_Silent_p.V806V|IQGAP2_uc003kel.2_Silent_p.V806V|IQGAP2_uc010izw.1_Silent_p.V11V	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1310					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		TAATTGATGTGATCCGGAACC	0.398			NA											7	40					2.0095e-06	2.53831e-06	0.001984	1	0
RASA1	5921	broad.mit.edu	37	5	86672763	86672763	+	Silent	SNP	A	A	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr5:86672763A>T	uc003kiw.2	+	17	2368	c.2250A>T	c.(2248-2250)ACA>ACT	p.T750T	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Silent_p.T573T|RASA1_uc011ctv.1_Silent_p.T583T|RASA1_uc011ctw.1_Silent_p.T584T|RASA1_uc010jaw.2_Silent_p.T572T	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	750	Ras-GAP.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		AAGACCGAACACTACTGGCCA	0.368			NA											22	137					0	0	0.016522	0	0
C5orf56	441108	broad.mit.edu	37	5	131822192	131822192	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr5:131822192G>C	uc010jds.1	+	4	528	c.353G>C	c.(352-354)AGA>ACA	p.R118T	IRF1_uc003kxd.2_Intron|IRF1_uc003kxa.2_Intron|IRF1_uc003kxb.2_Intron|IRF1_uc010jdt.1_Intron			Q8N8D9	CE056_HUMAN	Homo sapiens full length insert cDNA clone ZA99C08.	Error:Variant_position_missing_in_Q8N8D9_after_alignment											0						ATGCCTCCAAGAGAAAGAGTC	0.582			NA											7	20					0	0	0.001984	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719632	140719632	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr5:140719632T>C	uc003ljk.1	+	1	1279	c.1094T>C	c.(1093-1095)ATA>ACA	p.I365T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.I365T	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	365	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGGAACCATAATTGGGCTT	0.428			NA											27	179					0	0	0.00632	0	0
PCDH12	51294	broad.mit.edu	37	5	141325354	141325354	+	Silent	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr5:141325354C>T	uc003llx.2	-	4	4358	c.3147G>A	c.(3145-3147)CGG>CGA	p.R1049R		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	1049	Cytoplasmic (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCGCTCAGCCGGTCCAGGG	0.677			NA											3	61					0	0	0.004672	0	0
CSF1R	1436	broad.mit.edu	37	5	149449602	149449602	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr5:149449602C>A	uc003lrl.2	-	9	1539	c.1344G>T	c.(1342-1344)CAG>CAT	p.Q448H	CSF1R_uc011dcd.1_Missense_Mutation_p.Q300H|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Missense_Mutation_p.Q448H	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	448	Ig-like C2-type 5.|Extracellular (Potential).				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	CATCCCAGACCTGCAGCACTT	0.587			NA											12	69					1.05317e-09	1.60715e-09	0.020292	1	0
SLC36A3	285641	broad.mit.edu	37	5	150656993	150656993	+	Silent	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr5:150656993G>T	uc003ltw.2	-	10	1793	c.1374C>A	c.(1372-1374)ATC>ATA	p.I458I	GM2A_uc011dcs.1_Intron|SLC36A3_uc003ltv.2_Silent_p.I443I|SLC36A3_uc003ltx.2_Silent_p.I499I	NM_181774	NP_861439	Q495N2	S36A3_HUMAN	solute carrier family 36, member 3 isoform 2	458	Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGGAATGGCTGATGGGTTGGG	0.478			NA											20	203					8.34094e-07	1.07415e-06	0.008871	1	0
RIPK1	8737	broad.mit.edu	37	6	3105762	3105762	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr6:3105762G>T	uc010jni.2	+	9	1285	c.1053G>T	c.(1051-1053)ATG>ATT	p.M351I	RIPK1_uc003muv.3_Missense_Mutation_p.M188I|RIPK1_uc003muw.3_Missense_Mutation_p.M286I|RIPK1_uc011dhs.1_Missense_Mutation_p.M305I|RIPK1_uc003mux.2_Missense_Mutation_p.M351I	NM_003804	NP_003795	Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine	351	Interaction with SQSTM1.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			large_intestine(3)|lung(1)|skin(1)	5	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				GACTTGGGATGGGTCCTGTGG	0.493			NA											37	306					2.04263e-09	3.08146e-09	0.019004	1	0
ALDH5A1	7915	broad.mit.edu	37	6	24503644	24503644	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr6:24503644G>C	uc003neg.2	+	3	620	c.592G>C	c.(592-594)GCT>CCT	p.A198P	ALDH5A1_uc003nef.2_Missense_Mutation_p.A198P	NM_001080	NP_001071	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5A1 isoform 2 precursor	198					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity				0					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	CATAGGCGTGGCTGCAGTCAT	0.567			NA											6	54					0	0	0.001984	0	0
ZNF165	7718	broad.mit.edu	37	6	28056964	28056964	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr6:28056964C>T	uc003nkg.2	+	5	2258	c.1174C>T	c.(1174-1176)CGA>TGA	p.R392*	ZNF165_uc003nkh.2_Nonsense_Mutation_p.R392*|ZNF165_uc003nki.3_Nonsense_Mutation_p.R392*|ZSCAN12P1_uc003nkj.3_5'Flank	NM_003447	NP_003438	P49910	ZN165_HUMAN	zinc finger protein 165	392	C2H2-type 3.				viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TAGACATCGGCGAATTCACAC	0.448			NA											5	93					0	0	0.001168	0	0
OR12D2	26529	broad.mit.edu	37	6	29364990	29364990	+	Missense_Mutation	SNP	A	A	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr6:29364990A>C	uc003nmf.3	+	1	575	c.514A>C	c.(514-516)ATC>CTC	p.I172L		NM_013936	NP_039224	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D,	172	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTCCAACCGTATCCATCATTT	0.478			NA											13	244					0	0	0.00499	0	0
TNXB	7148	broad.mit.edu	37	6	32052275	32052275	+	Silent	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr6:32052275C>A	uc003nzl.2	-	8	3562	c.3360G>T	c.(3358-3360)CTG>CTT	p.L1120L		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1207	Fibronectin type-III 4.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GGCCAGGATCCAGGGAGGTGA	0.582			NA											6	28					0.00116845	0.00130156	0.001168	1	0
NOTCH4	4855	broad.mit.edu	37	6	32187987	32187987	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr6:32187987G>A	uc003obb.2	-	7	1373	c.1234C>T	c.(1234-1236)CTC>TTC	p.L412F	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc003obc.2_Missense_Mutation_p.L412F	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	412	EGF-like 10.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GAGCCTGTGAGGGGGTTGGTG	0.627			NA											5	62					0	0	0.006214	0	0
CUL9	23113	broad.mit.edu	37	6	43152465	43152465	+	Silent	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr6:43152465G>A	uc003ouk.2	+	2	492	c.417G>A	c.(415-417)ACG>ACA	p.T139T	CUL9_uc003ouj.1_Silent_p.T139T|CUL9_uc003oul.2_Silent_p.T139T|CUL9_uc010jyk.2_5'UTR|CUL9_uc003oum.1_5'Flank	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	139					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						CAAGCCTCACGGCCGCTGTGC	0.637			NA											4	61					0	0	0.016723	0	0
RARS2	57038	broad.mit.edu	37	6	88228554	88228554	+	Silent	SNP	T	T	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr6:88228554T>A	uc003pme.2	-	15	1353	c.1293A>T	c.(1291-1293)GCA>GCT	p.A431A	RARS2_uc003pmb.2_Silent_p.A256A|RARS2_uc003pmc.2_Silent_p.A256A|RARS2_uc003pmd.2_Silent_p.A68A|RARS2_uc003pmf.2_RNA	NM_020320	NP_064716	Q5T160	SYRM_HUMAN	arginyl-tRNA synthetase 2, mitochondrial	431					arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)		GAATAATGAGTGCTGCGAGCC	0.463			NA											9	71					0	0	0.006214	0	0
GABRR1	2569	broad.mit.edu	37	6	89891759	89891759	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr6:89891759A>T	uc003pna.2	-	8	1269	c.814T>A	c.(814-816)TAC>AAC	p.Y272N	GABRR1_uc011dzv.1_Missense_Mutation_p.Y249N	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	272	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	AAATTAATGTAGAGACGGTTG	0.448			NA											8	85					0	0	0.006214	0	0
TRAF3IP2	10758	broad.mit.edu	37	6	111913163	111913163	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr6:111913163C>A	uc011ebc.1	-	3	742	c.127G>T	c.(127-129)GCA>TCA	p.A43S	TRAF3IP2_uc003pvg.2_Missense_Mutation_p.A43S|TRAF3IP2_uc003pvf.2_Missense_Mutation_p.A43S|TRAF3IP2_uc010kdw.2_Missense_Mutation_p.A43S|TRAF3IP2_uc010kdx.2_Missense_Mutation_p.A43S	NM_147686	NP_679211	O43734	CIKS_HUMAN	TRAF3 interacting protein 2 isoform 2	52					intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				ovary(2)|central_nervous_system(1)	3		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		CTGTTGGGTGCCATGTTCCTT	0.478			NA											21	146					1.96292e-10	3.12176e-10	0.010504	1	0
IFNGR1	3459	broad.mit.edu	37	6	137519214	137519214	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr6:137519214G>A	uc003qho.2	-	7	1527	c.1424C>T	c.(1423-1425)TCC>TTC	p.S475F	IFNGR1_uc011edm.1_Missense_Mutation_p.S447F	NM_000416	NP_000407	P15260	INGR1_HUMAN	interferon gamma receptor 1 precursor	475	Cytoplasmic (Potential).				regulation of interferon-gamma-mediated signaling pathway|response to virus	integral to plasma membrane	interferon-gamma receptor activity			upper_aerodigestive_tract(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000829)|OV - Ovarian serous cystadenocarcinoma(155;0.00389)	Interferon gamma-1b(DB00033)	ACCAATCAAGGACTCTTTACC	0.413			NA											17	173					0	0	0.00499	0	0
SYNE1	23345	broad.mit.edu	37	6	152949423	152949423	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr6:152949423G>T	uc010kiw.2	-	3	646	c.44C>A	c.(43-45)GCC>GAC	p.A15D	SYNE1_uc003qot.3_Missense_Mutation_p.A15D|SYNE1_uc003qou.3_Missense_Mutation_p.A15D|SYNE1_uc010kjb.1_Missense_Mutation_p.A15D|SYNE1_uc003qpa.1_Missense_Mutation_p.A15D	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	15	Actin-binding.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CATCACATTGGCGATATCCCG	0.498			NA								HNSCC(10;0.0054)			33	225					5.8336e-16	1.06212e-15	0.015359	1	0
SNX9	51429	broad.mit.edu	37	6	158317937	158317937	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr6:158317937G>C	uc003qqv.1	+	5	552	c.379G>C	c.(379-381)GCC>CCC	p.A127P		NM_016224	NP_057308	Q9Y5X1	SNX9_HUMAN	sorting nexin 9	127					cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		AGGCTGGGGGGCCCAGCCAGA	0.587			NA											20	186					0	0	0.01892	0	0
SOD2	6648	broad.mit.edu	37	6	160103667	160103667	+	Missense_Mutation	SNP	A	A	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr6:160103667A>C	uc003qsg.2	-	5	681	c.527T>G	c.(526-528)CTT>CGT	p.L176R	SOD2_uc003qsf.3_5'Flank|SOD2_uc003qsh.2_Missense_Mutation_p.L137R|SOD2_uc003qsi.1_Missense_Mutation_p.L176R|SOD2_uc011efu.1_Missense_Mutation_p.L116R|SOD2_uc011efv.1_Missense_Mutation_p.L137R	NM_001024465	NP_001019636	P04179	SODM_HUMAN	manganese superoxide dismutase isoform A	176					age-dependent response to reactive oxygen species|negative regulation of neuron apoptosis|oxygen homeostasis|protein homotetramerization|regulation of transcription from RNA polymerase II promoter|release of cytochrome c from mitochondria|removal of superoxide radicals|vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure		manganese ion binding|superoxide dismutase activity				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.103)		OV - Ovarian serous cystadenocarcinoma(65;1.4e-18)|BRCA - Breast invasive adenocarcinoma(81;5.77e-06)		CAGTGGAATAAGGCCTGTTAG	0.368			NA											5	62					0	0	0.014758	0	0
SLC29A4	222962	broad.mit.edu	37	7	5338634	5338634	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr7:5338634G>T	uc003sod.2	+	8	1059	c.898G>T	c.(898-900)GCC>TCC	p.A300S	SLC29A4_uc011jwg.1_RNA|SLC29A4_uc003soc.2_Missense_Mutation_p.A300S|SLC29A4_uc003soe.2_Missense_Mutation_p.A286S|SLC29A4_uc010ksw.2_RNA	NM_153247	NP_694979	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (nucleoside	300	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			liver(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		CCCAGCCCCGGCCCTGGCCCC	0.672			NA											3	24					0.00024832	0.000286273	0.009096	1	0
CRHR2	1395	broad.mit.edu	37	7	30693085	30693085	+	Silent	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr7:30693085G>A	uc003tbn.2	-	12	1471	c.1227C>T	c.(1225-1227)GCC>GCT	p.A409A	CRHR2_uc010kvw.1_3'UTR|CRHR2_uc010kvx.1_Silent_p.A408A|CRHR2_uc010kvy.1_Silent_p.A245A|CRHR2_uc003tbo.2_Silent_p.A395A|CRHR2_uc003tbp.2_Silent_p.A436A	NM_001883	NP_001874	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	409	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(2)|ovary(1)|skin(1)	4						GTCACACAGCGGCCGTCTGCT	0.642			NA											22	117					0	0	0.01892	0	0
RALA	5898	broad.mit.edu	37	7	39730128	39730128	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr7:39730128G>T	uc003thd.2	+	3	562	c.262G>T	c.(262-264)GGG>TGG	p.G88W		NM_005402	NP_005393	P11233	RALA_HUMAN	ras related v-ral simian leukemia viral oncogene	88					actin cytoskeleton reorganization|cell cycle|chemotaxis|cytokinesis|exocytosis|interspecies interaction between organisms|membrane raft localization|nerve growth factor receptor signaling pathway|positive regulation of filopodium assembly|Ras protein signal transduction|regulation of exocytosis	cell surface|cleavage furrow|cytosol|midbody|plasma membrane	Edg-2 lysophosphatidic acid receptor binding|GTP binding|GTPase activity			lung(1)|skin(1)	2						AAGTGGGGAGGGGTTCCTCTG	0.458			NA											16	85					1.15088e-07	1.55016e-07	0.004007	1	0
GRB10	2887	broad.mit.edu	37	7	50742267	50742267	+	Silent	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr7:50742267C>A	uc003tpi.2	-	3	259	c.228G>T	c.(226-228)ACG>ACT	p.T76T	GRB10_uc003tph.3_Silent_p.T18T|GRB10_uc003tpj.2_Silent_p.T76T|GRB10_uc003tpk.2_Silent_p.T76T|GRB10_uc010kzb.2_Silent_p.T18T|GRB10_uc003tpl.2_Silent_p.T70T|GRB10_uc003tpm.2_Silent_p.T18T|GRB10_uc003tpn.2_Silent_p.T18T	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	76					insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)					GGAGGGGCACCGTGTCTGACT	0.622			NA							Russell-Silver_syndrome				3	49					6.4e-05	7.61081e-05	0.004672	1	0
CACNA2D1	781	broad.mit.edu	37	7	81662148	81662148	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr7:81662148G>T	uc003uhr.1	-	12	1364	c.1108C>A	c.(1108-1110)CAG>AAG	p.Q370K		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	370	Extracellular (Potential).|VWFA.					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	AATATCTCCTGGGCTCTCTCT	0.279			NA											12	94					7.93312e-07	1.02664e-06	0.020292	1	0
ABCB4	5244	broad.mit.edu	37	7	87031499	87031499	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr7:87031499C>G	uc003uiv.1	-	28	3850	c.3774G>C	c.(3772-3774)AAG>AAC	p.K1258N	ABCB4_uc003uiw.1_Missense_Mutation_p.K1251N|ABCB4_uc003uix.1_Missense_Mutation_p.K1204N	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	1258	ABC transporter 2.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TGCCATGCTCCTTGACTCTCC	0.498			NA											15	145					0	0	0.004007	0	0
SAMD9L	219285	broad.mit.edu	37	7	92761347	92761347	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr7:92761347C>T	uc003umh.1	-	5	5154	c.3938G>A	c.(3937-3939)TGT>TAT	p.C1313Y	SAMD9L_uc003umj.1_Missense_Mutation_p.C1313Y|SAMD9L_uc003umi.1_Missense_Mutation_p.C1313Y|SAMD9L_uc010lfb.1_Missense_Mutation_p.C1313Y|SAMD9L_uc003umk.1_Missense_Mutation_p.C1313Y|SAMD9L_uc010lfc.1_Missense_Mutation_p.C1313Y|SAMD9L_uc010lfd.1_Missense_Mutation_p.C1313Y|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1313										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TTGTAATAGACATGGATCCAA	0.378			NA											6	236					0	0	0.001168	0	0
NRCAM	4897	broad.mit.edu	37	7	107808728	107808728	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr7:107808728C>A	uc003vfb.2	-	29	3778	c.3307G>T	c.(3307-3309)GCA>TCA	p.A1103S	NRCAM_uc003vfc.2_Intron|NRCAM_uc011kmk.1_Intron|NRCAM_uc003vfd.2_Intron|NRCAM_uc003vfe.2_Intron|NRCAM_uc011kmj.1_Intron	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	1103	Fibronectin type-III 5.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						TTACTGCCTGCTACACCATAT	0.363			NA											9	73					3.09899e-07	4.13198e-07	0.004482	1	0
CFTR	1080	broad.mit.edu	37	7	117232483	117232483	+	Silent	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr7:117232483G>A	uc003vjd.2	+	14	2394	c.2262G>A	c.(2260-2262)GTG>GTA	p.V754V	CFTR_uc011knq.1_Silent_p.V160V	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	754	Cytoplasmic (Potential).		V -> M (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GCATCAGCGTGATCAGCACTG	0.517			NA							Cystic_Fibrosis				8	34					0	0	0.00308	0	0
KEL	3792	broad.mit.edu	37	7	142641424	142641424	+	Missense_Mutation	SNP	G	G	T	rs61729050		TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr7:142641424G>T	uc003wcb.2	-	13	1687	c.1477C>A	c.(1477-1479)CAA>AAA	p.Q493K		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	493	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					TTGTATTCTTGTCGGGCCAGC	0.522			NA											11	98					1.08611e-07	1.478e-07	0.010729	1	0
OR2A5	393046	broad.mit.edu	37	7	143748277	143748277	+	Silent	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr7:143748277C>A	uc011ktw.1	+	1	783	c.783C>A	c.(781-783)GCC>GCA	p.A261A		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					TGTACATGGCCCCCAAGTCCC	0.572			NA											14	127					7.07596e-05	8.37692e-05	0.006122	1	0
ZNF777	27153	broad.mit.edu	37	7	149153030	149153030	+	Silent	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr7:149153030G>A	uc003wfv.2	-	2	247	c.84C>T	c.(82-84)CCC>CCT	p.P28P		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	28					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GAGTTTCTCGGGGGAGTCCAG	0.547			NA											16	99					0	0	0.004007	0	0
PTPRN2	5799	broad.mit.edu	37	7	157475536	157475536	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr7:157475536C>A	uc003wno.2	-	13	2003	c.1882G>T	c.(1882-1884)GGC>TGC	p.G628C	PTPRN2_uc003wnp.2_Missense_Mutation_p.G611C|PTPRN2_uc003wnq.2_Missense_Mutation_p.G599C|PTPRN2_uc003wnr.2_Missense_Mutation_p.G590C|PTPRN2_uc011kwa.1_Missense_Mutation_p.G651C	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	628	Helical; (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		AGGAGGACGCCCAGGATGCAG	0.607			NA											8	87					0.000442599	0.000503648	0.006214	1	0
FZD3	7976	broad.mit.edu	37	8	28385432	28385432	+	Silent	SNP	T	T	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr8:28385432T>A	uc003xgx.2	+	5	1633	c.1155T>A	c.(1153-1155)GTT>GTA	p.V385V	FZD3_uc010lvb.2_Silent_p.V385V	NM_017412	NP_059108	Q9NPG1	FZD3_HUMAN	frizzled 3 precursor	385	Helical; Name=5; (Potential).				canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		ATGTGGTAGTTGGGGTTTCTC	0.398			NA											31	168					0	0	0.012213	0	0
KIF13B	23303	broad.mit.edu	37	8	29035078	29035078	+	Silent	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr8:29035078C>A	uc003xhh.3	-	9	797	c.738G>T	c.(736-738)GTG>GTT	p.V246V	KIF13B_uc003xhj.2_Silent_p.V143V|KIF13B_uc010lvf.1_Silent_p.V182V	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	246	Kinesin-motor.				microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		TGAGTTTGCCCACTTTCTCTC	0.378			NA											16	148					1.67942e-08	2.4096e-08	0.006122	1	0
UNC5D	137970	broad.mit.edu	37	8	35608274	35608274	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr8:35608274C>G	uc003xjr.1	+	13	2438	c.2110C>G	c.(2110-2112)CTG>GTG	p.L704V	UNC5D_uc003xjs.1_Missense_Mutation_p.L699V|UNC5D_uc003xju.1_Missense_Mutation_p.L280V	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	704	Cytoplasmic (Potential).|Interaction with DCC (By similarity).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CTGTAACTCCCTGGATTACAA	0.458			NA											41	228					0	0	0.010771	0	0
IKBKB	3551	broad.mit.edu	37	8	42178306	42178306	+	Silent	SNP	T	T	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr8:42178306T>C	uc003xow.1	+	16	1809	c.1632T>C	c.(1630-1632)ATT>ATC	p.I544I	IKBKB_uc010lxh.1_3'UTR|IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Silent_p.I321I|IKBKB_uc003xox.1_Silent_p.I265I|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Silent_p.I542I|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Silent_p.I485I	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	544					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	AGACCGACATTGTGGACTTAC	0.572			NA											4	93					0	0	0.009096	0	0
SLC20A2	6575	broad.mit.edu	37	8	42287590	42287590	+	Silent	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr8:42287590C>A	uc010lxl.2	-	9	2395	c.1701G>T	c.(1699-1701)ACG>ACT	p.T567T	SLC20A2_uc010lxm.2_Silent_p.T567T|SLC20A2_uc003xpe.2_Silent_p.T567T|SLC20A2_uc011lcu.1_Silent_p.T369T	NM_006749	NP_006740	Q08357	S20A2_HUMAN	solute carrier family 20, member 2	567	Cytoplasmic (Potential).				interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			ovary(2)	2	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			ACCTGGACGGCGTGATGGGAG	0.607			NA											7	46					1.06961e-07	1.478e-07	0.00308	1	0
PDE7A	5150	broad.mit.edu	37	8	66635829	66635829	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr8:66635829C>A	uc003xvq.2	-	12	1202	c.1190G>T	c.(1189-1191)GGT>GTT	p.G397V	PDE7A_uc003xvr.2_Missense_Mutation_p.G397V|PDE7A_uc003xvp.2_Missense_Mutation_p.G371V	NM_002604	NP_002595	Q13946	PDE7A_HUMAN	phosphodiesterase 7A isoform b	397	Catalytic (By similarity).					cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding				0			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	TGGACTCACACCCAAATGATA	0.294			NA											6	70					0.00307968	0.00335965	0.00308	1	0
ZFHX4	79776	broad.mit.edu	37	8	77618186	77618186	+	Silent	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr8:77618186G>T	uc003yav.2	+	2	2250	c.1863G>T	c.(1861-1863)GTG>GTT	p.V621V	ZFHX4_uc003yat.1_Silent_p.V621V|ZFHX4_uc003yau.1_Silent_p.V621V|ZFHX4_uc003yaw.1_Silent_p.V621V	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	621	C2H2-type 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCGACACTGTGTTGGGGTCTT	0.532			NA								HNSCC(33;0.089)			13	72					0.000151284	0.000175943	0.016723	1	0
ZFHX4	79776	broad.mit.edu	37	8	77690667	77690667	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr8:77690667A>T	uc003yav.2	+	4	3626	c.3239A>T	c.(3238-3240)AAT>ATT	p.N1080I	ZFHX4_uc003yau.1_Missense_Mutation_p.N1106I|ZFHX4_uc003yaw.1_Missense_Mutation_p.N1080I	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1080						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGCCCACCAAATGAGCTTGGT	0.453			NA								HNSCC(33;0.089)			17	121					0	0	0.004007	0	0
UBR5	51366	broad.mit.edu	37	8	103266711	103266711	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr8:103266711G>A	uc003ykr.1	-	59	8252	c.8219C>T	c.(8218-8220)CCA>CTA	p.P2740L	UBR5_uc003yks.1_Missense_Mutation_p.P2739L|UBR5_uc003ykq.2_Missense_Mutation_p.P251L	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2740	Pro-rich.|HECT.				cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TTCACTGGCTGGCAGTGATGG	0.408	Ovarian(131;96 1741 5634 7352 27489)		NA											11	73					0	0	0.008291	0	0
PHF20L1	51105	broad.mit.edu	37	8	133823374	133823374	+	Splice_Site	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr8:133823374G>T	uc003ytt.2	+	9	1255	c.930_splice	c.e9+1	p.Q310_splice	PHF20L1_uc003ytr.2_Missense_Mutation_p.V285L|PHF20L1_uc010mdv.2_Missense_Mutation_p.V285L|PHF20L1_uc003yts.2_Splice_Site_p.Q310_splice|PHF20L1_uc011lja.1_Splice_Site_p.Q284_splice|PHF20L1_uc003ytu.1_Splice_Site|PHF20L1_uc003ytv.2_Missense_Mutation_p.V150L	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1								nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GCTGGAGCAGGTATGAAATGG	0.403			NA											14	105					4.3838e-07	5.75783e-07	0.016723	1	0
COL22A1	169044	broad.mit.edu	37	8	139737684	139737684	+	Splice_Site	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr8:139737684C>A	uc003yvd.2	-	24	2587	c.2140_splice	c.e24-1	p.G714_splice	COL22A1_uc011ljo.1_Splice_Site_p.G14_splice	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1						cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTGGAGGGCCCTGTAGAGAAA	0.572			NA								HNSCC(7;0.00092)			21	111					3.7963e-18	7.21025e-18	0.01892	1	0
PYCRL	65263	broad.mit.edu	37	8	144689140	144689140	+	Silent	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr8:144689140G>A	uc003yyy.2	-	3	365	c.355C>T	c.(355-357)CTG>TTG	p.L119L	PYCRL_uc011lkm.1_Silent_p.L119L|PYCRL_uc011lkn.1_RNA	NM_023078	NP_075566	Q53H96	P5CR3_HUMAN	pyrroline-5-carboxylate reductase-like	107					proline biosynthetic process		pyrroline-5-carboxylate reductase activity				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			AGGGTGCTCAGAGACACCCCA	0.632			NA											9	65					0	0	0.004482	0	0
PLEC	5339	broad.mit.edu	37	8	145001143	145001143	+	Splice_Site	SNP	A	A	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr8:145001143A>T	uc003zaf.1	-	29	4526	c.4356_splice	c.e29+1	p.E1452_splice	PLEC_uc003zab.1_Splice_Site_p.E1315_splice|PLEC_uc003zac.1_Splice_Site_p.E1319_splice|PLEC_uc003zad.2_Splice_Site_p.E1315_splice|PLEC_uc003zae.1_Splice_Site_p.E1283_splice|PLEC_uc003zag.1_Splice_Site_p.E1293_splice|PLEC_uc003zah.2_Splice_Site_p.E1301_splice|PLEC_uc003zaj.2_Splice_Site_p.E1342_splice	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1						cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCCCCACCCTACCTCCTGGAT	0.637			NA											3	51					0	0	0.004672	0	0
PLEC	5339	broad.mit.edu	37	8	145001150	145001150	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr8:145001150G>T	uc003zaf.1	-	29	4521	c.4351C>A	c.(4351-4353)CAG>AAG	p.Q1451K	PLEC_uc003zab.1_Missense_Mutation_p.Q1314K|PLEC_uc003zac.1_Missense_Mutation_p.Q1318K|PLEC_uc003zad.2_Missense_Mutation_p.Q1314K|PLEC_uc003zae.1_Missense_Mutation_p.Q1282K|PLEC_uc003zag.1_Missense_Mutation_p.Q1292K|PLEC_uc003zah.2_Missense_Mutation_p.Q1300K|PLEC_uc003zaj.2_Missense_Mutation_p.Q1341K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1451	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CCTACCTCCTGGATGACACTC	0.632			NA											3	53					6.4e-05	7.61081e-05	0.004672	1	0
ZNF251	90987	broad.mit.edu	37	8	145948533	145948533	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr8:145948533C>A	uc003zdv.3	-	5	768	c.512G>T	c.(511-513)GGC>GTC	p.G171V		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		TCTTTCCCTGCCCACGGTAGC	0.433			NA											31	172					3.86903e-22	7.67988e-22	0.013726	1	0
GLIPR2	152007	broad.mit.edu	37	9	36162380	36162380	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr9:36162380G>T	uc003zyz.2	+	5	360	c.326G>T	c.(325-327)TGG>TTG	p.W109L	GLIPR2_uc010mlf.1_3'UTR|GLIPR2_uc003zza.2_RNA|GLIPR2_uc003zyy.1_Intron	NM_022343	NP_071738	Q9H4G4	GAPR1_HUMAN	GLI pathogenesis-related 2	109				TGHFTAMVWKNTKKMGVGKASASDGSSFVVARYFPAGNVVN EGFFEENVLPPKK -> IRFFFFNFLLFLSKPLLYFSYF (in Ref. 3; BAC11019).		extracellular region|Golgi membrane				skin(3)|central_nervous_system(1)	4						GCCATGGTATGGAAGAACACC	0.567			NA											21	121					1.50039e-11	2.50698e-11	0.012319	1	0
S1PR3	1903	broad.mit.edu	37	9	91617197	91617197	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr9:91617197C>A	uc004aqe.2	+	2	1478	c.1082C>A	c.(1081-1083)TCA>TAA	p.S361*		NM_005226	NP_005217	Q99500	S1PR3_HUMAN	sphingosine-1-phosphate receptor 3	361	Cytoplasmic (By similarity).				anatomical structure morphogenesis|elevation of cytosolic calcium ion concentration|inflammatory response|positive regulation of cell proliferation	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)|central_nervous_system(1)|skin(1)	5						ACAGCCCCCTCATCCTGCATC	0.537			NA											7	32					0.00307968	0.00335965	0.00308	1	0
ACTL7B	10880	broad.mit.edu	37	9	111618088	111618088	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr9:111618088C>T	uc004bdi.2	-	1	188	c.123G>A	c.(121-123)ATG>ATA	p.M41I		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	actin-like 7B	41						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			pancreas(1)	1						TCCTGGGCTTCATCTTGAGCT	0.657			NA											18	107					0	0	0.007413	0	0
TNC	3371	broad.mit.edu	37	9	117803262	117803262	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr9:117803262C>T	uc004bjj.3	-	19	5712	c.5350G>A	c.(5350-5352)GGC>AGC	p.G1784S	TNC_uc010mvf.2_Missense_Mutation_p.G1511S	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1784	Fibronectin type-III 13.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						TCCTCAAAGCCCTTCATGGCG	0.502			NA											39	118					0	0	0.006999	0	0
CEP110	11064	broad.mit.edu	37	9	123920082	123920082	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr9:123920082G>T	uc004bkx.1	+	27	4592	c.4561G>T	c.(4561-4563)GAA>TAA	p.E1521*	CEP110_uc004bla.1_Nonsense_Mutation_p.E969*|CEP110_uc010mvo.1_Nonsense_Mutation_p.E190*|CEP110_uc004blb.1_Nonsense_Mutation_p.E190*|CEP110_uc010mvp.1_5'UTR	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	1521	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						AATCTTGAAAGAAATAAACAA	0.408			NA											21	112					1.01871e-10	1.63988e-10	0.008871	1	0
LCN2	3934	broad.mit.edu	37	9	130911883	130911883	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr9:130911883C>A	uc004bto.1	+	1	152	c.79C>A	c.(79-81)CTG>ATG	p.L27M	LCN2_uc010mxq.1_Missense_Mutation_p.L27M|LCN2_uc011map.1_Missense_Mutation_p.L27M	NM_005564	NP_005555	P80188	NGAL_HUMAN	lipocalin 2 precursor	27					apoptosis|innate immune response|regulation of apoptosis|siderophore transport		iron ion binding|transporter activity				0						CACCTCAGACCTGATCCCAGC	0.642			NA											27	75					1.04121e-07	1.45439e-07	0.005443	1	0
LCN1	3933	broad.mit.edu	37	9	138415808	138415808	+	Silent	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr9:138415808G>A	uc004cfz.1	+	4	433	c.375G>A	c.(373-375)GGG>GGA	p.G125G	LCN1_uc004cga.1_Silent_p.G125G	NM_002297	NP_002288	P31025	LCN1_HUMAN	lipocalin 1 precursor	125					proteolysis|response to stimulus|sensory perception of taste	extracellular region	cysteine-type endopeptidase inhibitor activity|transporter activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.54e-08)|Epithelial(140;5.25e-08)|all cancers(34;9.27e-07)|READ - Rectum adenocarcinoma(205;0.155)		AGCTGCACGGGAAGCCGGTCC	0.642			NA											3	33					0	0	0.001984	0	0
BCOR	54880	broad.mit.edu	37	X	39932097	39932097	+	Silent	SNP	G	G	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chrX:39932097G>A	uc004den.3	-	4	2794	c.2502C>T	c.(2500-2502)AGC>AGT	p.S834S	BCOR_uc004dep.3_Silent_p.S834S|BCOR_uc004deo.3_Silent_p.S834S|BCOR_uc004dem.3_Silent_p.S834S|BCOR_uc004deq.3_Silent_p.S834S	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	834					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						GGGGCTCAGCGCTCTGGCCAA	0.557			NA											13	62					0	0	0.013537	0	0
PHF16	9767	broad.mit.edu	37	X	46918161	46918161	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chrX:46918161G>T	uc004dgx.2	+	11	2205	c.2154G>T	c.(2152-2154)GAG>GAT	p.E718D	PHF16_uc004dgy.2_Missense_Mutation_p.E718D	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	718					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0						CCTTTAAAGAGACCACCAATA	0.498			NA											10	57					0.000442599	0.000503648	0.006214	1	0
FOXP3	50943	broad.mit.edu	37	X	49108150	49108150	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chrX:49108150A>T	uc004dnf.3	-	11	1309	c.1121T>A	c.(1120-1122)TTC>TAC	p.F374Y	FOXP3_uc011mnb.1_Missense_Mutation_p.F397Y|FOXP3_uc011mnc.1_Missense_Mutation_p.F347Y|FOXP3_uc004dne.3_Missense_Mutation_p.F339Y|FOXP3_uc010niq.1_Missense_Mutation_p.F339Y	NM_014009	NP_054728	Q9BZS1	FOXP3_HUMAN	forkhead box P3 isoform a	374	Fork-head.				B cell homeostasis|cerebellum development|chromatin remodeling|embryo development|myeloid cell homeostasis|negative regulation of activated T cell proliferation|negative regulation of chronic inflammatory response|negative regulation of CREB transcription factor activity|negative regulation of cytokine secretion|negative regulation of histone acetylation|negative regulation of histone deacetylation|negative regulation of interferon-gamma biosynthetic process|negative regulation of interferon-gamma production|negative regulation of interleukin-10 production|negative regulation of interleukin-2 biosynthetic process|negative regulation of interleukin-2 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of interleukin-6 production|negative regulation of isotype switching to IgE isotypes|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell cytokine production|negative regulation of tumor necrosis factor production|pattern specification process|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|positive regulation of histone acetylation|positive regulation of immature T cell proliferation in thymus|positive regulation of peripheral T cell tolerance induction|positive regulation of T cell anergy|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor-beta1 production|post-embryonic development|regulation of isotype switching to IgG isotypes|response to virus|T cell homeostasis|T cell receptor signaling pathway|tolerance induction to self antigen	cytoplasm|cytoplasm|nucleus|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|histone acetyltransferase binding|histone deacetylase binding|NF-kappaB binding|NFAT protein binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription corepressor activity|zinc ion binding				0	Ovarian(276;0.236)					ATGGTTTCTGAAGAAGGCAAA	0.587	GBM(182;1432 2112 16160 23073 31774)		NA											5	25					0	0	0.001168	0	0
HUWE1	10075	broad.mit.edu	37	X	53581722	53581722	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chrX:53581722G>C	uc004dsp.2	-	61	8768	c.8366C>G	c.(8365-8367)TCT>TGT	p.S2789C	HUWE1_uc004dsn.2_Missense_Mutation_p.S1613C	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	2789					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TCCAGCTGGAGACTGCAGCTC	0.557			NA											3	96					0	0	0.009096	0	0
ARHGEF9	23229	broad.mit.edu	37	X	62926160	62926160	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chrX:62926160T>A	uc004dvl.2	-	3	1198	c.359A>T	c.(358-360)AAG>ATG	p.K120M	ARHGEF9_uc004dvj.1_Missense_Mutation_p.K9M|ARHGEF9_uc004dvk.1_Translation_Start_Site|ARHGEF9_uc011mos.1_Missense_Mutation_p.K99M|ARHGEF9_uc004dvm.1_Missense_Mutation_p.K99M|ARHGEF9_uc011mot.1_Missense_Mutation_p.K67M|ARHGEF9_uc004dvn.2_Missense_Mutation_p.K127M	NM_015185	NP_056000	O43307	ARHG9_HUMAN	Cdc42 guanine exchange factor 9	120	DH.				apoptosis|induction of apoptosis by extracellular signals|ion transmembrane transport|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(5)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	8						CTTGAGGTGCTTGATGTAGTG	0.537			NA											3	22					0	0	0.004672	0	0
MAGEE1	57692	broad.mit.edu	37	X	75650121	75650121	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chrX:75650121G>T	uc004ecm.1	+	1	2005	c.1798G>T	c.(1798-1800)GAG>TAG	p.E600*		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	600	MAGE 1.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						CCAAGCCAAGGAGGCTGAGAT	0.502			NA											6	39					2.0095e-06	2.53831e-06	0.001984	1	0
BRWD3	254065	broad.mit.edu	37	X	79978240	79978240	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chrX:79978240C>A	uc004edt.2	-	17	1960	c.1697G>T	c.(1696-1698)CGT>CTT	p.R566L	BRWD3_uc004edo.2_Missense_Mutation_p.R162L|BRWD3_uc004edp.2_Missense_Mutation_p.R395L|BRWD3_uc004edq.2_Missense_Mutation_p.R162L|BRWD3_uc010nmj.1_Missense_Mutation_p.R162L|BRWD3_uc004edr.2_Missense_Mutation_p.R236L|BRWD3_uc004eds.2_Missense_Mutation_p.R162L|BRWD3_uc004edu.2_Missense_Mutation_p.R236L|BRWD3_uc004edv.2_Missense_Mutation_p.R162L|BRWD3_uc004edw.2_Missense_Mutation_p.R162L|BRWD3_uc004edx.2_Missense_Mutation_p.R162L|BRWD3_uc004edy.2_Missense_Mutation_p.R162L|BRWD3_uc004edz.2_Missense_Mutation_p.R236L|BRWD3_uc004eea.2_Missense_Mutation_p.R236L|BRWD3_uc004eeb.2_Missense_Mutation_p.R162L	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	566										ovary(4)	4						ATTGGCATCACGAATAAGAGG	0.393			NA											15	134					0.00316338	0.00343676	0.003163	1	0
POF1B	79983	broad.mit.edu	37	X	84606415	84606415	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chrX:84606415C>T	uc004eer.2	-	5	627	c.481G>A	c.(481-483)GGA>AGA	p.G161R	POF1B_uc004ees.2_Missense_Mutation_p.G161R	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	161							actin binding				0						ACATTGTTTCCTGGGAAGAAA	0.284			NA											9	95					0	0	0.004482	0	0
PCDH11X	27328	broad.mit.edu	37	X	91132563	91132563	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chrX:91132563G>T	uc004efk.1	+	2	2169	c.1324G>T	c.(1324-1326)GGC>TGC	p.G442C	PCDH11X_uc004efl.1_Missense_Mutation_p.G442C|PCDH11X_uc004efo.1_Missense_Mutation_p.G442C|PCDH11X_uc010nmv.1_Missense_Mutation_p.G442C|PCDH11X_uc004efm.1_Missense_Mutation_p.G442C|PCDH11X_uc004efn.1_Missense_Mutation_p.G442C|PCDH11X_uc004efh.1_Missense_Mutation_p.G442C|PCDH11X_uc004efj.1_Missense_Mutation_p.G442C	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	442	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TGCAGATGCTGGCAAACCTCC	0.408	NSCLC(38;925 1092 2571 38200 45895)		NA											23	95					8.16721e-17	1.50779e-16	0.010818	1	0
HTR2C	3358	broad.mit.edu	37	X	114141816	114141816	+	Silent	SNP	T	T	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chrX:114141816T>A	uc004epu.1	+	6	1943	c.1215T>A	c.(1213-1215)GCT>GCA	p.A405A	HTR2C_uc010nqc.1_Silent_p.A405A|HTR2C_uc004epv.1_3'UTR	NM_000868	NP_000859	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C	405	Cytoplasmic (By similarity).				cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			ovary(3)	3					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	CCGCCACTGCTTTGTCTGGGA	0.453			NA											25	156					0	0	0.009535	0	0
KIAA1210	57481	broad.mit.edu	37	X	118220652	118220652	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chrX:118220652C>A	uc004era.3	-	11	4541	c.4541G>T	c.(4540-4542)AGG>ATG	p.R1514M		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1514										ovary(4)|skin(1)	5						TTTATGTCCCCTGCCTACAGA	0.502			NA											14	61					7.93312e-07	1.02664e-06	0.020292	1	0
DCAF12L2	340578	broad.mit.edu	37	X	125298619	125298619	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chrX:125298619G>C	uc004euk.1	-	1	1316	c.1289C>G	c.(1288-1290)GCG>GGG	p.A430G		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	430										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						GGTGTAGAGCGCATTGGGGAA	0.602			NA											27	160					0	0	0.007291	0	0
ZIC3	7547	broad.mit.edu	37	X	136649500	136649500	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chrX:136649500C>G	uc004fak.2	+	1	1155	c.650C>G	c.(649-651)CCT>CGT	p.P217R		NM_003413	NP_003404	O60481	ZIC3_HUMAN	zinc finger protein of the cerebellum 3	217			P -> A (in a patient with atrial septal defect and pulmonic stenosis not associated with heterotaxy; lacks DNA- binding; does not inhibit transcriptional activation and interaction with GLI3).		cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P217A(1)		ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GCTCAGTTTCCTAACTACAGC	0.662			NA											6	55					0	0	0.001984	0	0
VCAM1	7412	broad.mit.edu	37	1	101186128	101186128	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr1:101186128delC	uc001dti.2	+	2	281	c.161delC	c.(160-162)TCCfs	p.S54fs	VCAM1_uc001dtj.2_Frame_Shift_Del_p.S54fs|VCAM1_uc010ouj.1_Intron	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	54	Ig-like C2-type 1.|Extracellular (Potential).				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	GGCTGTGAGTCCCCATTTTTC	0.468			NA											21	115	---	---	---	---	NA	NA	NA	NA	NA
FZD10	11211	broad.mit.edu	37	12	130648791	130648791	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr12:130648791delA	uc001uii.2	+	1	1760	c.1304delA	c.(1303-1305)GACfs	p.D435fs	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	435	Cytoplasmic (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		GAGAACACGGACAAGCTGGAG	0.602			NA											10	62	---	---	---	---	NA	NA	NA	NA	NA
LOC220429	220429	broad.mit.edu	37	13	50466803	50466803	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr13:50466803delC	uc001vdk.2	+	1	2259	c.2077delC	c.(2077-2079)CCAfs	p.P693fs		NR_003268				Homo sapiens CTAGE family, member 5 pseudogene, mRNA (cDNA clone IMAGE:5270026).												0						CTTTGTTCCTCCACCTCTTGC	0.493			NA											49	407	---	---	---	---	NA	NA	NA	NA	NA
PCK1	5105	broad.mit.edu	37	20	56137217	56137217	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr20:56137217delC	uc002xyn.3	+	3	478	c.315delC	c.(313-315)ATCfs	p.I105fs	PCK1_uc010zzm.1_Intron	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	105					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CAGTGCCCATCCCCAAAACAG	0.547			NA											7	76	---	---	---	---	NA	NA	NA	NA	NA
DBR1	51163	broad.mit.edu	37	3	137880741	137880743	+	In_Frame_Del	DEL	TCG	TCG	-	rs150114751	byFrequency	TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	TCG	TCG	-	-	TCG	TCG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr3:137880741_137880743delTCG	uc003erv.2	-	8	1759_1761	c.1623_1625delCGA	c.(1621-1626)GATGAT>GAT	p.541_542DD>D	DBR1_uc003eru.2_In_Frame_Del_p.490_491DD>D|DBR1_uc003ert.2_In_Frame_Del_p.309_310DD>D	NM_016216	NP_057300	Q9UK59	DBR1_HUMAN	debranching enzyme homolog 1	541_542						nucleus	metal ion binding|RNA lariat debranching enzyme activity				0						TTAAGCTGCATCGTCATCATCAT	0.251			NA											10	197	---	---	---	---	NA	NA	NA	NA	NA
EXT1	2131	broad.mit.edu	37	8	118812003	118812004	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chr8:118812003_118812004insG	uc003yok.1	-	11	2961_2962	c.2188_2189insC	c.(2188-2190)AAAfs	p.K730fs		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	730	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			GACCTGGTCTTTAAAGAGGACG	0.535			NA	Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				8	85	---	---	---	---	NA	NA	NA	NA	NA
NOX1	27035	broad.mit.edu	37	X	100125757	100125760	+	Frame_Shift_Del	DEL	AGGA	AGGA	-			TCGA-44-2655-01A-01D-1553-08	TCGA-44-2655-11A-01D-1553-08	AGGA	AGGA	-	-	AGGA	AGGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2f866c6e-34b1-4aa0-bbaa-9a9919c1fc13	e2e670a2-4521-4fb9-85e0-9c26cf0f71d6	g.chrX:100125757_100125760delAGGA	uc004egj.2	-	2	295_298	c.89_92delTCCT	c.(88-93)TTCCTGfs	p.F30fs	uc010nnf.2_Intron|NOX1_uc004egl.3_Frame_Shift_Del_p.F30fs|NOX1_uc010nne.2_Frame_Shift_Del_p.F30fs	NM_007052	NP_008983	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1 isoform long	30_31	Extracellular (Potential).				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			ovary(1)	1						CTCATATTTCAGGAAGGCATCCAC	0.377			NA											16	176	---	---	---	---	NA	NA	NA	NA	NA
