Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CPSF3L	54973	broad.mit.edu	37	1	1250237	1250237	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:1250237C>G	uc001aee.1	-	7	727	c.669G>C	c.(667-669)AAG>AAC	p.K223N	CPSF3L_uc009vjy.1_RNA|CPSF3L_uc001aef.1_Missense_Mutation_p.K229N|CPSF3L_uc009vjz.1_Missense_Mutation_p.K201N|CPSF3L_uc010nyj.1_Missense_Mutation_p.K194N|CPSF3L_uc001aeg.1_Missense_Mutation_p.K99N|CPSF3L_uc001aeh.1_Missense_Mutation_p.K122N|CPSF3L_uc001aei.1_Missense_Mutation_p.K125N|CPSF3L_uc001aej.1_Missense_Mutation_p.K50N|CPSF3L_uc001aek.1_5'UTR	NM_017871	NP_060341	Q5TA45	INT11_HUMAN	cleavage and polyadenylation specific factor	223						Golgi apparatus|nucleus	hydrolase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(86;4.35e-21)|Colorectal(212;0.000166)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.00235)|BRCA - Breast invasive adenocarcinoma(365;0.00255)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0349)|Lung(427;0.201)		CGTGGACTTTCTTCAGGAAGT	0.632			NA											17	92					0	0	0.00499	0	0
RPL22	6146	broad.mit.edu	37	1	6253091	6253091	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:6253091G>C	uc001amd.2	-	3	187	c.141C>G	c.(139-141)ATC>ATG	p.I47M	RPL22_uc001ame.2_Missense_Mutation_p.I47M	NM_000983	NP_000974	P35268	RL22_HUMAN	ribosomal protein L22 proprotein	47					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	heparin binding|RNA binding|structural constituent of ribosome				0	Ovarian(185;0.0634)	all_cancers(23;2.78e-38)|all_epithelial(116;8.88e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.53e-38)|GBM - Glioblastoma multiforme(13;3.33e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.8e-19)|Colorectal(212;6.8e-08)|COAD - Colon adenocarcinoma(227;8.04e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		CGTTCACTTTGATCCTTTCTT	0.438			NA	T	RUNX1	AML|CML								11	146					0	0	0.001368	0	0
PEX14	5195	broad.mit.edu	37	1	10555367	10555367	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:10555367C>G	uc001arn.2	+	2	94	c.73C>G	c.(73-75)CGA>GGA	p.R25G	PEX14_uc001arm.1_RNA|PEX14_uc009vmu.1_Missense_Mutation_p.R25G|PEX14_uc009vmv.2_Intron|PEX14_uc010oam.1_5'UTR|PEX14_uc010oan.1_Missense_Mutation_p.R25G|PEX14_uc001arl.2_RNA	NM_004565	NP_004556	O75381	PEX14_HUMAN	peroxisomal biogenesis factor 14	25					negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|protein homooligomerization|protein import into peroxisome matrix|transmembrane transport	integral to membrane|nucleus|peroxisomal membrane|protein complex	protein N-terminus binding|transcription corepressor activity			breast(1)	1	Ovarian(185;0.203)	all_lung(284;6.02e-06)|Lung NSC(185;9.62e-06)|Renal(390;0.000147)|Breast(348;0.000932)|Colorectal(325;0.00215)|Hepatocellular(190;0.00913)|Ovarian(437;0.023)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0292)|Colorectal(212;9.13e-08)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000482)|Kidney(185;0.00174)|KIRC - Kidney renal clear cell carcinoma(229;0.00457)|STAD - Stomach adenocarcinoma(132;0.0249)|READ - Rectum adenocarcinoma(331;0.0419)		TGTGCTGCCTCGAGAGCCGCT	0.433			NA									OREG0013090	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	54					0	0	0.00308	0	0
NPPA	4878	broad.mit.edu	37	1	11907671	11907671	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:11907671C>G	uc001ati.2	-	1	170	c.71G>C	c.(70-72)AGA>ACA	p.R24T	CLCN6_uc010oav.1_RNA|CLCN6_uc010oaw.1_RNA|CLCN6_uc010oax.1_RNA|CLCN6_uc010oay.1_RNA|CLCN6_uc010oaz.1_RNA|CLCN6_uc010oba.1_RNA	NM_006172	NP_006163	P01160	ANF_HUMAN	natriuretic peptide precursor A preproprotein	24					cGMP biosynthetic process|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size	extracellular region	hormone activity			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGGATTAGCTCTGGTCTGACC	0.562			NA											28	273					0	0	0.00632	0	0
RPL11	6135	broad.mit.edu	37	1	24021184	24021184	+	Missense_Mutation	SNP	C	C	T	rs11556036		TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:24021184C>T	uc001bhk.2	+	4	319	c.299C>T	c.(298-300)TCA>TTA	p.S100L	RPL11_uc001bhl.2_Missense_Mutation_p.S99L|RPL11_uc001bhm.2_Missense_Mutation_p.S89L|RPL11_uc001bhn.1_Missense_Mutation_p.S89L	NM_000975	NP_000966	P62913	RL11_HUMAN	ribosomal protein L11	100					endocrine pancreas development|protein localization to nucleus|protein targeting|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.13e-24)|Colorectal(126;5.06e-08)|COAD - Colon adenocarcinoma(152;2.92e-06)|GBM - Glioblastoma multiforme(114;4.4e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|KIRC - Kidney renal clear cell carcinoma(1967;0.00322)|STAD - Stomach adenocarcinoma(196;0.0124)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0837)|LUSC - Lung squamous cell carcinoma(448;0.185)		AACAACTTCTCAGATACTGGA	0.438			NA											33	123					0	0	0.009535	0	0
MACF1	23499	broad.mit.edu	37	1	39797800	39797800	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:39797800C>T	uc010oiu.1	+	1	991	c.860C>T	c.(859-861)TCA>TTA	p.S287L	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1852					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TCCCTCTGGTCATTCATGGGG	0.463			NA											34	151					0	0	0.002445	0	0
KIAA0467	23334	broad.mit.edu	37	1	43893319	43893319	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:43893319C>T	uc001cjk.1	+	11	1482	c.1020C>T	c.(1018-1020)GTC>GTT	p.V340V		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1239						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GGTGTCCTGTCTACATCTACA	0.602			NA											19	140					0	0	0.007413	0	0
HYI	81888	broad.mit.edu	37	1	43917151	43917151	+	Silent	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:43917151G>A	uc001cjo.2	-	7	860	c.690C>T	c.(688-690)TTC>TTT	p.F230F	KIAA0467_uc001cjk.1_3'UTR|KIAA0467_uc001cjl.1_3'UTR|HYI_uc001cjm.2_Silent_p.F157F|HYI_uc001cjn.2_Silent_p.F230F|HYI_uc001cjp.2_Silent_p.F157F	NM_031207	NP_112484	Q5T013	HYI_HUMAN	hydroxypyruvate isomerase homolog	230							hydroxypyruvate isomerase activity			ovary(1)	1	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ACAGATAGGGGAAATTCAGCT	0.607			NA											38	128					0	0	0.004878	0	0
ERI3	79033	broad.mit.edu	37	1	44785335	44785335	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:44785335C>T	uc001clt.2	-	4	812	c.571G>A	c.(571-573)GTA>ATA	p.V191I	ERI3_uc010okv.1_Missense_Mutation_p.V14I|ERI3_uc009vxg.2_Missense_Mutation_p.V191I|ERI3_uc010okw.1_Missense_Mutation_p.V113I|ERI3_uc001clu.2_Missense_Mutation_p.V113I	NM_024066	NP_076971	O43414	ERI3_HUMAN	prion protein interacting protein	191	Exonuclease.					intracellular	exonuclease activity|metal ion binding|nucleic acid binding			ovary(2)|large_intestine(1)	3						GGATGGACTACAGGCTGGACA	0.517			NA											18	215					0	0	0.007413	0	0
GPBP1L1	60313	broad.mit.edu	37	1	46120223	46120223	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:46120223C>T	uc001coq.2	-	6	1830	c.469G>A	c.(469-471)GAG>AAG	p.E157K		NM_021639	NP_067652	Q9HC44	GPBL1_HUMAN	GC-rich promoter binding protein 1-like 1	157					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					ACAAAGTCCTCCTCTTCAAAC	0.388			NA											13	141					0	0	0.004007	0	0
C1orf87	127795	broad.mit.edu	37	1	60505791	60505791	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:60505791C>G	uc001czs.1	-	5	637	c.545G>C	c.(544-546)AGA>ACA	p.R182T		NM_152377	NP_689590	Q8N0U7	CA087_HUMAN	hypothetical protein LOC127795	182							calcium ion binding			ovary(1)|breast(1)	2						GAGTTCTCTTCTGACCAGGGC	0.423	NSCLC(75;811 1386 4923 13371 51772)		NA											40	183					0	0	0.005524	0	0
ST6GALNAC3	256435	broad.mit.edu	37	1	77094490	77094490	+	Nonstop_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:77094490G>C	uc001dhh.2	+	5	1080	c.917G>C	c.(916-918)TGA>TCA	p.*306S	ST6GALNAC3_uc010orh.1_Nonstop_Mutation_p.*205S	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	306					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						ACATTGTCTTGATAATGGTTT	0.318			NA											32	118					0	0	0.002836	0	0
EVI5	7813	broad.mit.edu	37	1	93159385	93159385	+	Silent	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:93159385G>A	uc001dox.2	-	9	1213	c.1203C>T	c.(1201-1203)GTC>GTT	p.V401V	EVI5_uc010otf.1_Silent_p.V401V|EVI5_uc001doy.1_RNA	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	401	Dimerization.|Targeting to the centrosomes.|Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		AATTGTATTTGACTTGGTAAG	0.308			NA											39	215					0	0	0.002522	0	0
AP4B1	10717	broad.mit.edu	37	1	114438396	114438396	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:114438396G>T	uc001eeb.2	-	9	1918	c.1775C>A	c.(1774-1776)TCA>TAA	p.S592*	uc001edv.1_Intron|AP4B1_uc001eec.2_Nonsense_Mutation_p.S424*|AP4B1_uc001eed.2_Nonsense_Mutation_p.S592*|AP4B1_uc010owp.1_Nonsense_Mutation_p.S493*|AP4B1_uc001eea.1_3'UTR|AP4B1_uc001eee.1_Nonsense_Mutation_p.S119*	NM_006594	NP_006585	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1	592					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			ovary(3)|central_nervous_system(1)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGCAAAGGATGAAGTTTTAGG	0.443			NA											19	88					6.33239e-15	7.5492e-15	0.010504	1	0
GDAP2	54834	broad.mit.edu	37	1	118420645	118420645	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:118420645C>T	uc001ehf.2	-	13	1731	c.1432G>A	c.(1432-1434)GAA>AAA	p.E478K	GDAP2_uc001ehg.2_Missense_Mutation_p.E478K	NM_017686	NP_060156	Q9NXN4	GDAP2_HUMAN	ganglioside induced differentiation associated	478	CRAL-TRIO.									ovary(2)	2		all_cancers(81;0.0156)|all_lung(203;5.81e-05)|Lung NSC(69;0.000446)|all_epithelial(167;0.00295)		Lung(183;0.0583)|LUSC - Lung squamous cell carcinoma(189;0.194)		GCATCATATTCAAGGACAAAA	0.453			NA											12	110					0	0	0.004007	0	0
SMG5	23381	broad.mit.edu	37	1	156244470	156244470	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:156244470C>G	uc001foc.3	-	5	611	c.462G>C	c.(460-462)AAG>AAC	p.K154N		NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	154					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					ACACTGGCTTCTTGCATCCTA	0.473			NA											34	124					0	0	0.003755	0	0
OR10X1	128367	broad.mit.edu	37	1	158549566	158549566	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:158549566A>T	uc010pin.1	-	1	124	c.124T>A	c.(124-126)TTT>ATT	p.F42I		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	42	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					ACAAAAAGAAATGTCTGTACA	0.418			NA											21	133					0	0	0.008871	0	0
CACNA1E	777	broad.mit.edu	37	1	181480642	181480642	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:181480642A>G	uc001gow.2	+	3	673	c.508A>G	c.(508-510)AGT>GGT	p.S170G	CACNA1E_uc009wxr.2_Missense_Mutation_p.S77G|CACNA1E_uc009wxs.2_Missense_Mutation_p.S77G	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	170	I.|Helical; Name=S3 of repeat I.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CGTGGTCCTCAGTGGGTAAGT	0.522			NA											48	206					0	0	0.00361	0	0
DENND1B	163486	broad.mit.edu	37	1	197576259	197576259	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:197576259C>G	uc001guf.3	-	13	1203	c.865G>C	c.(865-867)GAT>CAT	p.D289H	DENND1B_uc010ppe.1_Missense_Mutation_p.D269H|DENND1B_uc010ppf.1_RNA|DENND1B_uc001gue.3_Missense_Mutation_p.D259H|DENND1B_uc001gug.3_Missense_Mutation_p.D88H	NM_144977	NP_659414	Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B isoform 2	289	DENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity				0						GTGTTTGTATCAACATTTAAC	0.294			NA											8	57					0	0	0.006214	0	0
ACTN2	88	broad.mit.edu	37	1	236908017	236908017	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:236908017C>G	uc001hyf.2	+	12	1551	c.1347C>G	c.(1345-1347)AGC>AGG	p.S449R	ACTN2_uc001hyg.2_Missense_Mutation_p.S241R|ACTN2_uc009xgi.1_Missense_Mutation_p.S449R|ACTN2_uc010pxu.1_Missense_Mutation_p.S138R|ACTN2_uc001hyh.2_Missense_Mutation_p.S137R	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	449	Spectrin 2.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CGTTCGAGAGCGACCTGGCAG	0.642			NA											17	73					0	0	0.00499	0	0
FMN2	56776	broad.mit.edu	37	1	240497523	240497523	+	Missense_Mutation	SNP	T	T	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:240497523T>G	uc010pyd.1	+	13	4984	c.4759T>G	c.(4759-4761)TTG>GTG	p.L1587V	FMN2_uc010pye.1_Missense_Mutation_p.L1591V|FMN2_uc010pyf.1_Missense_Mutation_p.L233V|FMN2_uc010pyg.1_Missense_Mutation_p.L183V	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1587	FH2.|Potential.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GAAGAAAGACTTGAAAGGTAA	0.353			NA											19	305					0	0	0.010504	0	0
PLD5	200150	broad.mit.edu	37	1	242271010	242271010	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:242271010G>T	uc001hzn.1	-	8	1329	c.1202C>A	c.(1201-1203)GCG>GAG	p.A401E	PLD5_uc001hzl.3_Missense_Mutation_p.A339E|PLD5_uc001hzm.3_Missense_Mutation_p.A191E|PLD5_uc001hzo.1_Missense_Mutation_p.A309E			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	401						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			AGTGCAAATCGCTTTAAGAGA	0.368			NA											51	193					2.01807e-28	2.48378e-28	0.00361	1	0
KIF26B	55083	broad.mit.edu	37	1	245530604	245530604	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:245530604C>T	uc001ibf.1	+	3	1374	c.934C>T	c.(934-936)CAC>TAC	p.H312Y	KIF26B_uc010pyq.1_Missense_Mutation_p.H312Y|KIF26B_uc010pyr.1_Missense_Mutation_p.H112Y	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	312					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CATCCAGGCTCACCAGTACCT	0.592			NA											6	20					0	0	0.00308	0	0
OR2W5	441932	broad.mit.edu	37	1	247655162	247655162	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:247655162C>A	uc001icz.1	+	1	733	c.733C>A	c.(733-735)CCT>ACT	p.P245T		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	245					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GCTCTTCTCACCTCACAGTGG	0.542			NA											44	253					2.40228e-13	2.79806e-13	0.003214	1	0
OR1C1	26188	broad.mit.edu	37	1	247920842	247920842	+	Silent	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:247920842G>T	uc010pza.1	-	1	867	c.867C>A	c.(865-867)ATC>ATA	p.I289I		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TTAGGGTATAGATGAAAGGAT	0.458			NA											24	142					9.86323e-18	1.18515e-17	0.003954	1	0
OR2L8	391190	broad.mit.edu	37	1	248112672	248112672	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:248112672G>T	uc001idt.1	+	1	513	c.513G>T	c.(511-513)AGG>AGT	p.R171S	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GCCGATCCAGGGCCATCAATC	0.483			NA											56	230					2.27459e-33	2.84558e-33	0.00361	1	0
OR2M4	26245	broad.mit.edu	37	1	248403046	248403046	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:248403046G>C	uc010pzh.1	+	1	816	c.816G>C	c.(814-816)AAG>AAC	p.K272N		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	272	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACCAGGACAAGATGGTGTCGG	0.502			NA											13	117					0	0	0.001855	0	0
KIN	22944	broad.mit.edu	37	10	7820880	7820880	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr10:7820880T>A	uc001ijt.2	-	5	527	c.479A>T	c.(478-480)AAG>ATG	p.K160M	KIN_uc010qaz.1_RNA|KIN_uc009xip.2_Missense_Mutation_p.K160M|KIN_uc010qba.1_Missense_Mutation_p.K54M	NM_012311	NP_036443	O60870	KIN17_HUMAN	HsKin17 protein	160	Potential.				DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AAGGTCCTGCTTTTTCTTTTT	0.453			NA											35	274					0	0	0.002445	0	0
SLC39A12	221074	broad.mit.edu	37	10	18292133	18292133	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr10:18292133C>G	uc001ipo.2	+	12	2066	c.1793C>G	c.(1792-1794)TCT>TGT	p.S598C	SLC39A12_uc001ipn.2_Missense_Mutation_p.S561C|SLC39A12_uc001ipp.2_Missense_Mutation_p.S597C|SLC39A12_uc010qck.1_Missense_Mutation_p.S464C|uc001ipq.1_RNA	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	598	Cytoplasmic (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						TCTGGACTTTCTATGAAGACT	0.408			NA											20	181					0	0	0.010504	0	0
DNAJC1	64215	broad.mit.edu	37	10	22048380	22048380	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr10:22048380C>T	uc001irc.2	-	11	1602	c.1315G>A	c.(1315-1317)GAT>AAT	p.D439N	DNAJC1_uc001ird.2_Missense_Mutation_p.D325N	NM_022365	NP_071760	Q96KC8	DNJC1_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 1	439	Cytoplasmic (By similarity).				negative regulation of proteolysis|regulation of protein secretion|regulation of transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	ATPase activator activity|DNA binding|heat shock protein binding|unfolded protein binding			lung(1)	1		Breast(68;0.00869)|Prostate(175;0.0181)|Lung SC(717;0.0262)				GGCCGGGCATCAGTGGCCCCG	0.662			NA											6	47					0	0	0.001984	0	0
UNC5B	219699	broad.mit.edu	37	10	73053578	73053578	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr10:73053578C>G	uc001jro.2	+	13	2508	c.2063C>G	c.(2062-2064)TCC>TGC	p.S688C	UNC5B_uc001jrp.2_Missense_Mutation_p.S677C	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	688	Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						GAGTCCTATTCCCGCTCAGCA	0.657			NA											6	21					0	0	0.001984	0	0
NRG3	10718	broad.mit.edu	37	10	83635863	83635863	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr10:83635863C>T	uc001kco.2	+	1	794	c.767C>T	c.(766-768)TCT>TTT	p.S256F	NRG3_uc010qlz.1_Missense_Mutation_p.S256F|NRG3_uc001kcp.2_5'Flank|NRG3_uc001kcq.2_5'Flank	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	256	Ser/Thr-rich.|Extracellular (Potential).|Poly-Ser.				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		tcttcttcctcttcttcctcc	0.433			NA											4	12					0	0	0.009096	0	0
ADD3	120	broad.mit.edu	37	10	111878416	111878416	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr10:111878416C>T	uc001kyt.3	+	7	953	c.639C>T	c.(637-639)TTC>TTT	p.F213F	ADD3_uc001kys.3_Silent_p.F213F|ADD3_uc001kyu.2_Silent_p.F213F|ADD3_uc001kyv.2_Silent_p.F213F|ADD3_uc001kyw.2_Silent_p.F213F	NM_016824	NP_058432	Q9UEY8	ADDG_HUMAN	adducin 3 (gamma) isoform a	213						cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			ovary(2)|skin(2)|large_intestine(1)	5		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)		ATACAGGATTCAGTCCCCATG	0.393			NA											20	64					0	0	0.010504	0	0
TACC2	10579	broad.mit.edu	37	10	123970013	123970013	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr10:123970013G>C	uc001lfv.2	+	9	6433	c.6073G>C	c.(6073-6075)GAT>CAT	p.D2025H	TACC2_uc001lfw.2_Missense_Mutation_p.D171H|TACC2_uc009xzx.2_Missense_Mutation_p.D1980H|TACC2_uc010qtv.1_Missense_Mutation_p.D2029H|TACC2_uc001lfx.2_5'UTR|TACC2_uc001lfy.2_5'UTR|TACC2_uc001lfz.2_Missense_Mutation_p.D103H|TACC2_uc001lga.2_Missense_Mutation_p.D103H|TACC2_uc009xzy.2_Missense_Mutation_p.D103H|TACC2_uc001lgb.2_Missense_Mutation_p.D60H|TACC2_uc010qtw.1_Missense_Mutation_p.D120H	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2025						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TGCCGTCTTCGATGAAGACAA	0.552			NA											13	24					0	0	0.001368	0	0
KNDC1	85442	broad.mit.edu	37	10	135032354	135032354	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr10:135032354C>G	uc001llz.1	+	27	4698	c.4697C>G	c.(4696-4698)TCC>TGC	p.S1566C		NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1566	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		AACTTGCTGTCCAAATTTTTG	0.463			NA											94	277					0	0	0.00361	0	0
LRDD	55367	broad.mit.edu	37	11	800571	800571	+	Silent	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr11:800571G>A	uc001lro.1	-	12	2155	c.2013C>T	c.(2011-2013)GCC>GCT	p.A671A	SLC25A22_uc009yci.2_5'Flank|SLC25A22_uc001lrj.2_5'Flank|LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Silent_p.A671A|LRDD_uc001lrl.1_Silent_p.A514A|LRDD_uc001lrm.1_Silent_p.A358A|LRDD_uc001lrn.1_Silent_p.A514A|LRDD_uc001lrp.1_Silent_p.A333A	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	671					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CGCGCTCGAAGGCCGCAAAGA	0.677			NA											8	66					0	0	0.006214	0	0
IGSF22	283284	broad.mit.edu	37	11	18735942	18735942	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr11:18735942C>T	uc009yht.2	-	13	1870	c.1680G>A	c.(1678-1680)CAG>CAA	p.Q560Q	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	560										ovary(4)|large_intestine(2)|kidney(1)	7						GCTTCACAATCTGCATGCCTG	0.597			NA											23	138					0	0	0.004656	0	0
LGR4	55366	broad.mit.edu	37	11	27389919	27389919	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr11:27389919G>A	uc001mrj.3	-	18	2836	c.2351C>T	c.(2350-2352)TCT>TTT	p.S784F	LGR4_uc001mrk.3_Missense_Mutation_p.S760F	NM_018490	NP_060960	Q9BXB1	LGR4_HUMAN	leucine-rich repeat-containing G protein-coupled	784	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			ovary(1)	1						CAGAGTAACAGACTTCATTAT	0.403			NA											15	112					0	0	0.003163	0	0
CD59	966	broad.mit.edu	37	11	33743968	33743968	+	Silent	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr11:33743968G>C	uc001mus.3	-	1	306	c.24C>G	c.(22-24)GTC>GTG	p.V8V	CD59_uc009yjx.2_Silent_p.V8V|CD59_uc009yjy.2_Silent_p.V8V|CD59_uc009yjz.2_Silent_p.V8V|CD59_uc001mut.3_Silent_p.V8V|CD59_uc009yka.2_Silent_p.V8V|CD59_uc001muu.3_Silent_p.V8V|CD59_uc001muv.3_Silent_p.V8V|CD59_uc001mux.3_Silent_p.V8V	NM_001127223	NP_001120695	P13987	CD59_HUMAN	CD59 antigen preproprotein	8					blood coagulation|cell surface receptor linked signaling pathway	anchored to external side of plasma membrane|extracellular region|membrane fraction					0						GCCCGAACAGGACAGACCCTC	0.537			NA											5	74					0	0	0.001168	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137225	40137225	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr11:40137225C>A	uc001mxa.1	-	2	2582	c.618G>T	c.(616-618)ATG>ATT	p.M206I	LRRC4C_uc001mxc.1_Missense_Mutation_p.M202I|LRRC4C_uc001mxd.1_Missense_Mutation_p.M202I|LRRC4C_uc001mxb.1_Missense_Mutation_p.M202I	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	206	LRR 6.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GAAGGTTGCACATGGCAAGGT	0.463			NA											19	140					8.10497e-08	9.02532e-08	0.010504	1	0
SLC22A8	9376	broad.mit.edu	37	11	62761244	62761244	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr11:62761244G>C	uc001nwo.2	-	9	1459	c.1323C>G	c.(1321-1323)ATC>ATG	p.I441M	SLC22A8_uc001nwn.1_3'UTR|SLC22A8_uc001nwp.2_Missense_Mutation_p.I441M|SLC22A8_uc009yom.2_Missense_Mutation_p.I318M|SLC22A8_uc010rmm.1_Missense_Mutation_p.I350M|SLC22A8_uc009yon.2_Missense_Mutation_p.I441M	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	441	Cytoplasmic (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						GCACCTACCTGATGACTGTGG	0.562			NA											9	97					0	0	0.000978	0	0
FRMD8	83786	broad.mit.edu	37	11	65154527	65154527	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr11:65154527G>T	uc001odu.3	+	2	212	c.20G>T	c.(19-21)AGT>ATT	p.S7I	FRMD8_uc009yqj.2_Missense_Mutation_p.S7I|FRMD8_uc010rof.1_Missense_Mutation_p.S7I	NM_031904	NP_114110	Q9BZ67	FRMD8_HUMAN	FERM domain containing 8	7						cytoskeleton	binding			lung(1)|pancreas(1)	2						ACAGAAGGCAGTGCCGGGCAG	0.657			NA											94	192					1.25848e-56	1.5809e-56	0.00361	1	0
CCDC87	55231	broad.mit.edu	37	11	66358453	66358453	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr11:66358453C>T	uc001oiq.3	-	1	2102	c.2034G>A	c.(2032-2034)CTG>CTA	p.L678L	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	678										ovary(1)|skin(1)	2						TCTGCAGGCTCAGAATTTTGT	0.532			NA											48	118					0	0	0.00361	0	0
SAPS3	55291	broad.mit.edu	37	11	68326137	68326137	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr11:68326137C>T	uc001onw.2	+	8	1102	c.835C>T	c.(835-837)CGA>TGA	p.R279*	SAPS3_uc001onv.2_Nonsense_Mutation_p.R279*|SAPS3_uc001ony.3_Nonsense_Mutation_p.R279*|SAPS3_uc001onx.2_Nonsense_Mutation_p.R279*|SAPS3_uc009ysh.2_Nonsense_Mutation_p.R279*|SAPS3_uc001onu.2_Nonsense_Mutation_p.R279*|SAPS3_uc010rqc.1_Intron|SAPS3_uc010rqd.1_Translation_Start_Site	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	279					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			ACTTGAGACACGACGACCAAC	0.348			NA											5	113					0	0	0.001168	0	0
SAPS3	55291	broad.mit.edu	37	11	68377414	68377414	+	Missense_Mutation	SNP	A	A	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr11:68377414A>C	uc001onw.2	+	23	2760	c.2493A>C	c.(2491-2493)AAA>AAC	p.K831N	SAPS3_uc001onv.2_Missense_Mutation_p.K837N|SAPS3_uc001ony.3_Missense_Mutation_p.K802N|SAPS3_uc001onx.2_Missense_Mutation_p.K825N|SAPS3_uc009ysh.2_Missense_Mutation_p.K751N|SAPS3_uc001onu.2_Missense_Mutation_p.K751N|SAPS3_uc010rqc.1_Missense_Mutation_p.K599N|SAPS3_uc010rqd.1_Missense_Mutation_p.K514N|SAPS3_uc001onz.2_Missense_Mutation_p.K159N|SAPS3_uc001ooa.2_Missense_Mutation_p.K287N	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	831					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			CTGCTTGTAAAGACGCAGAGG	0.592			NA											60	140					0	0	0.00361	0	0
UVRAG	7405	broad.mit.edu	37	11	75852254	75852254	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr11:75852254G>A	uc001oxc.2	+	15	2138	c.1897G>A	c.(1897-1899)GAA>AAA	p.E633K	UVRAG_uc010rrw.1_Missense_Mutation_p.E532K|UVRAG_uc001oxd.2_Missense_Mutation_p.E261K|UVRAG_uc010rrx.1_Missense_Mutation_p.E261K|UVRAG_uc010rry.1_Missense_Mutation_p.E189K	NM_003369	NP_003360	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	633					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			skin(4)|lung(2)	6						GGAGCAAGCAGAAGAAATCAT	0.567			NA											7	105					0	0	0.001984	0	0
PRKRIR	5612	broad.mit.edu	37	11	76062972	76062972	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr11:76062972G>A	uc001oxh.1	-	5	1222	c.1222C>T	c.(1222-1224)CTT>TTT	p.L408F	PRKRIR_uc010rrz.1_Missense_Mutation_p.L233F	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	408					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						TTCTGAAAAAGAACAGAAATT	0.383			NA											21	44					0	0	0.004656	0	0
CCDC90B	60492	broad.mit.edu	37	11	82985720	82985720	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr11:82985720C>G	uc001pae.2	-	4	750	c.388G>C	c.(388-390)GAG>CAG	p.E130Q	CCDC90B_uc001pac.2_Missense_Mutation_p.E29Q|CCDC90B_uc001pad.2_Missense_Mutation_p.E29Q|CCDC90B_uc001paf.2_Missense_Mutation_p.E121Q	NM_021825	NP_068597	Q9GZT6	CC90B_HUMAN	coiled-coil domain containing 90B precursor	130	Potential.					integral to membrane|mitochondrion|mitochondrion					0		Acute lymphoblastic leukemia(157;0.103)				TCACTTTTCTCTAGGATGACC	0.303			NA											13	48					0	0	0.004007	0	0
C11orf70	85016	broad.mit.edu	37	11	101953881	101953881	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr11:101953881G>A	uc001pgp.2	+	7	783	c.755G>A	c.(754-756)CGT>CAT	p.R252H	C11orf70_uc001pgq.2_Missense_Mutation_p.R214H	NM_032930	NP_116319	Q9BRQ4	CK070_HUMAN	hypothetical protein LOC85016	252										skin(1)	1	all_epithelial(12;0.0137)	Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.0137)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0335)		CCTATCAGGCGTCACCTTCAT	0.343			NA											60	174					0	0	0.00361	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106810208	106810208	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr11:106810208G>A	uc001pjg.1	-	4	1574	c.1184C>T	c.(1183-1185)TCT>TTT	p.S395F	GUCY1A2_uc010rvo.1_Missense_Mutation_p.S395F|GUCY1A2_uc009yxn.1_Missense_Mutation_p.S395F	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	395					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		TTCAGAGCCAGAAGCCTCAGG	0.438			NA											24	233					0	0	0.00278	0	0
ATN1	1822	broad.mit.edu	37	12	7045360	7045360	+	Silent	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr12:7045360C>G	uc001qrw.1	+	5	1167	c.930C>G	c.(928-930)CTC>CTG	p.L310L	ATN1_uc001qrx.1_Silent_p.L310L|ATN1_uc001qry.1_Silent_p.L309L	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	310					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						TGAGACCCCTCAACAATGCAT	0.637			NA											20	142					0	0	0.001882	0	0
DDX12	440081	broad.mit.edu	37	12	9572801	9572801	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr12:9572801C>T	uc010sgs.1	-	22	2448	c.2253G>A	c.(2251-2253)GCG>GCA	p.A751A	DDX12_uc001qvx.3_5'Flank|DDX12_uc001qvy.1_5'Flank	NM_004400	NP_004391			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12												0						ACCTGGAATACGCCAGCAGCA	0.557			NA											4	26					0	0	0.009096	0	0
ABCC9	10060	broad.mit.edu	37	12	21958203	21958203	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr12:21958203A>G	uc001rfi.1	-	38	4575	c.4555T>C	c.(4555-4557)TTT>CTT	p.F1519L	ABCC9_uc001rfh.2_Intron|ABCC9_uc001rfj.1_Missense_Mutation_p.F1483L|ABCC9_uc001rfg.2_Intron	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1519	Cytoplasmic (Potential).|ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CCCTCAGAAAAGACTAAAACA	0.423			NA											3	81					0	0	0.004672	0	0
ETNK1	55500	broad.mit.edu	37	12	22778145	22778145	+	Silent	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr12:22778145C>G	uc001rft.2	+	1	70	c.48C>G	c.(46-48)CTC>CTG	p.L16L	ETNK1_uc009ziz.2_Silent_p.L16L|ETNK1_uc001rfs.2_Silent_p.L16L	NM_018638	NP_061108	Q9HBU6	EKI1_HUMAN	ethanolamine kinase 1 isoform A	16					phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|ethanolamine kinase activity				0						GGAATTTTCTCCGAGAGCGGG	0.721	Esophageal Squamous(42;87 913 3224 6226 43339)		NA											4	45					0	0	0.009096	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54914904	54914904	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr12:54914904A>G	uc001sgc.3	+	18	1839	c.1760A>G	c.(1759-1761)TAC>TGC	p.Y587C	NCKAP1L_uc010sox.1_Missense_Mutation_p.Y129C|NCKAP1L_uc010soy.1_Missense_Mutation_p.Y537C	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	587					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						TTCCCATAGTACCCCCACCTC	0.493			NA											39	156					0	0	0.006999	0	0
DNAJC14	85406	broad.mit.edu	37	12	56217256	56217256	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr12:56217256C>G	uc001shx.1	-	3	1648	c.1444G>C	c.(1444-1446)GAG>CAG	p.E482Q	DNAJC14_uc001shu.1_Missense_Mutation_p.E482Q|DNAJC14_uc009zob.1_Missense_Mutation_p.E482Q	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	482	J.				protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						TTGAAGGCCTCCTCAGCCCGG	0.438			NA											20	110					0	0	0.010504	0	0
STAT2	6773	broad.mit.edu	37	12	56744927	56744927	+	Missense_Mutation	SNP	C	C	T	rs149666262		TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr12:56744927C>T	uc001slc.2	-	10	1067	c.989G>A	c.(988-990)CGA>CAA	p.R330Q	STAT2_uc001slb.2_5'Flank|STAT2_uc001sld.2_Missense_Mutation_p.R326Q|STAT2_uc010sqn.1_Missense_Mutation_p.R326Q	NM_005419	NP_005410	P52630	STAT2_HUMAN	signal transducer and activator of transcription	330					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						GATGAGGGGTCGATGGGGAGT	0.507			NA											33	169					0	0	0.006999	0	0
LRP1	4035	broad.mit.edu	37	12	57567684	57567684	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr12:57567684C>T	uc001snd.2	+	22	3934	c.3468C>T	c.(3466-3468)ACC>ACT	p.T1156T		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1156	LDL-receptor class A 10.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCAACAACACCTCAGTCTGCC	0.622			NA											39	114					0	0	0.006999	0	0
C12orf56	115749	broad.mit.edu	37	12	64678484	64678484	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr12:64678484C>G	uc001ssa.3	-	6	790	c.790G>C	c.(790-792)GAA>CAA	p.E264Q	uc001srx.2_Intron|C12orf56_uc001sry.2_Missense_Mutation_p.E6Q|C12orf56_uc001srz.2_5'UTR	NM_001099676	NP_001093146	Q8IXR9	CL056_HUMAN	hypothetical protein LOC115749	427											0			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		GACTCGGTTTCTGTTTCTCTG	0.373			NA											6	21					0	0	0.001984	0	0
TRHDE	29953	broad.mit.edu	37	12	72893294	72893294	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr12:72893294T>C	uc001sxa.2	+	6	1496	c.1466T>C	c.(1465-1467)CTG>CCG	p.L489P		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	489	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CAGAGGTTTCTGACCGATGTT	0.448			NA											15	75					0	0	0.00245	0	0
NAV3	89795	broad.mit.edu	37	12	78583831	78583831	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr12:78583831G>T	uc001syp.2	+	34	6296	c.6123G>T	c.(6121-6123)AGG>AGT	p.R2041S	NAV3_uc001syo.2_Missense_Mutation_p.R2019S|NAV3_uc010sub.1_Missense_Mutation_p.R1498S|NAV3_uc009zsf.2_Missense_Mutation_p.R850S	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	2041						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TTACCCAAAGGTACTTTAACT	0.348			NA								HNSCC(70;0.22)			8	110					0.000442599	0.000465572	0.006214	1	0
FAM71C	196472	broad.mit.edu	37	12	100041984	100041984	+	Missense_Mutation	SNP	C	C	T	rs146401531		TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr12:100041984C>T	uc001tgn.2	+	1	454	c.32C>T	c.(31-33)ACG>ATG	p.T11M	ANKS1B_uc001tge.1_Intron|ANKS1B_uc001tgf.1_Intron|ANKS1B_uc009ztt.1_Intron	NM_153364	NP_699195	Q8NEG0	FA71C_HUMAN	hypothetical protein LOC196472	11											0				OV - Ovarian serous cystadenocarcinoma(2;0.00733)|Epithelial(2;0.0385)|all cancers(2;0.19)		CCGTATTACACGGCCCAAAGC	0.507			NA											4	94					0	0	0.009096	0	0
CCDC60	160777	broad.mit.edu	37	12	119916949	119916949	+	Missense_Mutation	SNP	G	G	A	rs144234053		TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr12:119916949G>A	uc001txe.2	+	4	857	c.392G>A	c.(391-393)CGC>CAC	p.R131H	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	131								p.R131H(1)		ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		GTCACACGTCGCCCATTCACT	0.473			NA											5	59					0	0	0.001984	0	0
DNAH10	196385	broad.mit.edu	37	12	124323233	124323233	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr12:124323233C>G	uc001uft.3	+	28	4804	c.4779C>G	c.(4777-4779)ATC>ATG	p.I1593M		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1593	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGCACATGATCAAGGTCAGCC	0.557			NA											44	159					0	0	0.009718	0	0
FAM123A	219287	broad.mit.edu	37	13	25743889	25743889	+	Silent	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr13:25743889G>T	uc001uqb.2	-	1	1969	c.1869C>A	c.(1867-1869)CCC>CCA	p.P623P	FAM123A_uc001uqa.2_Silent_p.P504P|FAM123A_uc001uqc.2_Silent_p.P504P	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	623										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GGTGCACCACGGGATGGCTAG	0.562			NA											53	202					1.4709e-25	1.7958e-25	0.00361	1	0
COG3	83548	broad.mit.edu	37	13	46056606	46056606	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr13:46056606C>T	uc001vak.2	+	6	816	c.715C>T	c.(715-717)CAT>TAT	p.H239Y	COG3_uc010tfu.1_RNA|COG3_uc001vai.2_Missense_Mutation_p.H239Y|COG3_uc001vaj.1_Missense_Mutation_p.H239Y|COG3_uc010tfv.1_Missense_Mutation_p.H76Y|COG3_uc010aci.2_Missense_Mutation_p.H15Y	NM_031431	NP_113619	Q96JB2	COG3_HUMAN	component of golgi transport complex 3	239					ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|skin(1)	2		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		TATCTCATCTCATGTAAGTCA	0.328	Ovarian(150;1048 1859 18083 21577 42700)		NA											6	62					0	0	0.00308	0	0
OLFM4	10562	broad.mit.edu	37	13	53624648	53624648	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr13:53624648G>T	uc001vhl.2	+	5	1275	c.1275G>T	c.(1273-1275)CAG>CAT	p.Q425H	OLFM4_uc001vhk.1_3'UTR	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	425	Olfactomedin-like.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		ATACCAAGCAGTATAAACCAT	0.408			NA											15	133					4.14922e-12	4.77789e-12	0.004007	1	0
MYCBP2	23077	broad.mit.edu	37	13	77759506	77759506	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr13:77759506C>G	uc001vkf.2	-	33	4428	c.4337G>C	c.(4336-4338)GGA>GCA	p.G1446A	MYCBP2_uc010aev.2_Missense_Mutation_p.G850A	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1446					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AACTGCTTTTCCTGTAGCTTT	0.323			NA											42	169					0	0	0.002852	0	0
MYCBP2	23077	broad.mit.edu	37	13	77760049	77760049	+	Silent	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr13:77760049C>G	uc001vkf.2	-	32	4378	c.4287G>C	c.(4285-4287)CTG>CTC	p.L1429L	MYCBP2_uc010aev.2_Silent_p.L833L	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1429					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GCAATAACCTCAGACAACAGG	0.383			NA											12	71					0	0	0.00245	0	0
GPR183	1880	broad.mit.edu	37	13	99947431	99947431	+	Silent	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr13:99947431C>G	uc001vog.2	-	2	1143	c.969G>C	c.(967-969)CTG>CTC	p.L323L	UBAC2_uc001voa.3_Intron|UBAC2_uc010tiu.1_Intron|UBAC2_uc001vob.3_Intron|UBAC2_uc010tiv.1_Intron|UBAC2_uc001vod.2_Intron|UBAC2_uc001voc.2_Intron|UBAC2_uc010tiw.1_Intron	NM_004951	NP_004942	P32249	GP183_HUMAN	EBV-induced G protein-coupled receptor 2	323	Cytoplasmic (Potential).				humoral immune response|mature B cell differentiation involved in immune response	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled				0						CTTGCCGTTTCAGCATCCTCA	0.408			NA											26	129					0	0	0.003954	0	0
ZNF828	283489	broad.mit.edu	37	13	115090800	115090800	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr13:115090800G>A	uc010ahb.2	+	3	1812	c.1483G>A	c.(1483-1485)GAG>AAG	p.E495K	ZNF828_uc001vuv.2_Missense_Mutation_p.E495K|ZNF828_uc010tko.1_Missense_Mutation_p.E495K	NM_001164144	NP_001157616	Q96JM3	ZN828_HUMAN	zinc finger protein 828	495	Mediates localization to the spindle and the kinetochore and is required for the attachment of spindle microtubules to the kinetochore.|Pro-rich.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_epithelial(44;0.122)|all_lung(25;0.123)	BRCA - Breast invasive adenocarcinoma(86;0.104)	OV - Ovarian serous cystadenocarcinoma(48;0.193)|Epithelial(10;0.197)		TGTCTTCCCTGAGACCCGAAA	0.493			NA											113	381					0	0	0.00361	0	0
MTHFD1	4522	broad.mit.edu	37	14	64882110	64882110	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr14:64882110C>T	uc001xhb.2	+	5	662	c.275C>T	c.(274-276)TCT>TTT	p.S92F	MTHFD1_uc010aqe.2_Missense_Mutation_p.S128F|MTHFD1_uc010aqf.2_Missense_Mutation_p.S148F	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1	92	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	AATGAAGACTCTACTGTACAT	0.353	Colon(18;220 581 13419 18191 31512)|GBM(126;343 1658 28700 44425 52519)		NA											5	203					0	0	0.001168	0	0
NUMB	8650	broad.mit.edu	37	14	73749182	73749182	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr14:73749182G>C	uc001xny.1	-	11	1301	c.981C>G	c.(979-981)ATC>ATG	p.I327M	NUMB_uc010aro.1_Intron|NUMB_uc010arp.1_Intron|NUMB_uc010arq.1_Missense_Mutation_p.I229M|NUMB_uc010arr.1_Missense_Mutation_p.I218M|NUMB_uc001xoa.1_Missense_Mutation_p.I327M|NUMB_uc001xnz.1_Missense_Mutation_p.I316M|NUMB_uc001xob.1_Missense_Mutation_p.I316M|NUMB_uc001xod.1_Missense_Mutation_p.I327M|NUMB_uc001xoc.1_Missense_Mutation_p.I327M|NUMB_uc010ars.1_Missense_Mutation_p.I316M|NUMB_uc010ttz.1_Missense_Mutation_p.I73M	NM_001005743	NP_001005743	P49757	NUMB_HUMAN	numb homolog isoform 1	327					axon guidance|lateral ventricle development|neuroblast division in subventricular zone|positive regulation of neurogenesis	integral to plasma membrane				ovary(2)|central_nervous_system(1)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00471)|OV - Ovarian serous cystadenocarcinoma(108;0.161)		ACAGGGAGCTGATGCTCTCTG	0.438			NA											21	88					0	0	0.010504	0	0
C14orf174	161394	broad.mit.edu	37	14	77845256	77845256	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr14:77845256G>C	uc001xtq.1	+	1	1495	c.1495G>C	c.(1495-1497)GAG>CAG	p.E499Q	TMED8_uc010ast.1_5'Flank|TMED8_uc001xto.1_5'Flank	NM_001010860	NP_001010860	Q9P1V8	SAM15_HUMAN	hypothetical protein LOC161394	499											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0278)		AGATCCCTCAGAGTCTCAGAC	0.408			NA											21	82					0	0	0.002299	0	0
TTC8	123016	broad.mit.edu	37	14	89338775	89338775	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr14:89338775G>A	uc010ath.2	+	13	1508	c.1374G>A	c.(1372-1374)ATG>ATA	p.M458I	TTC8_uc001xxl.2_Missense_Mutation_p.M203I|TTC8_uc010ati.2_Missense_Mutation_p.M244I|TTC8_uc001xxm.2_Missense_Mutation_p.M402I|TTC8_uc010atj.2_Missense_Mutation_p.M177I|TTC8_uc001xxi.2_Missense_Mutation_p.M442I|TTC8_uc001xxj.2_Missense_Mutation_p.M432I|TTC8_uc001xxk.2_Missense_Mutation_p.M402I	NM_198309	NP_938051	Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8 isoform B	468	TPR 8.				cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding				0						TGCTGGAGATGCGGAAGGGCC	0.532			NA							Bardet-Biedl_syndrome				35	137					0	0	0.005524	0	0
AMN	81693	broad.mit.edu	37	14	103390271	103390271	+	Splice_Site	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr14:103390271G>A	uc001ymg.3	+	3	196	c.163_splice	c.e3-1	p.M55_splice	AMN_uc001ymh.3_Splice_Site_p.M1_splice	NM_030943	NP_112205	Q9BXJ7	AMNLS_HUMAN	amnionless protein precursor						lipid metabolic process|lipoprotein metabolic process|multicellular organismal development	integral to membrane|plasma membrane					0				Colorectal(3;0.00739)|READ - Rectum adenocarcinoma(2;0.0336)|Epithelial(152;0.0363)|all cancers(159;0.147)	Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TCTTCCTGCAGATGGTGTCAG	0.667			NA											45	153					0	0	0.00361	0	0
RYR3	6263	broad.mit.edu	37	15	34145245	34145245	+	Splice_Site	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr15:34145245G>T	uc001zhi.2	+	95	13699	c.13629_splice	c.e95-1	p.P4543_splice	RYR3_uc010bar.2_Splice_Site_p.P4538_splice	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3						cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTGTTTTTCAGATCTTTTCCT	0.383			NA											5	24					4.096e-09	4.66361e-09	0.001168	1	0
TYRO3	7301	broad.mit.edu	37	15	41865997	41865997	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr15:41865997G>C	uc001zof.1	+	18	2490	c.2266G>C	c.(2266-2268)GAG>CAG	p.E756Q		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	756	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		ACAGCCTCCGGAGTGTATGGA	0.552			NA											31	101					0	0	0.009535	0	0
TRPM7	54822	broad.mit.edu	37	15	50891429	50891429	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr15:50891429C>A	uc001zyt.3	-	22	3317	c.3053G>T	c.(3052-3054)AGA>ATA	p.R1018I	TRPM7_uc010bew.1_Missense_Mutation_p.R1018I	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	1018	Extracellular (Potential).				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TATTGCCTTTCTGGGAACACC	0.353			NA											29	113					1.7367e-05	1.89232e-05	0.00632	1	0
TTC23	64927	broad.mit.edu	37	15	99696503	99696503	+	Splice_Site	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr15:99696503C>T	uc002bur.2	-	11	1525	c.994_splice	c.e11-1	p.R332_splice	TTC23_uc002bus.2_Splice_Site_p.R332_splice|TTC23_uc002but.2_Splice_Site_p.R332_splice|TTC23_uc002buu.2_Splice_Site_p.R332_splice|TTC23_uc002buv.2_Splice_Site_p.R332_splice|TTC23_uc002bux.2_Splice_Site_p.R332_splice|TTC23_uc002buw.2_Splice_Site_p.R332_splice|TTC23_uc010boq.2_Splice_Site|TTC23_uc002buy.2_Splice_Site_p.R332_splice|TTC23_uc010bor.2_Splice_Site_p.R332_splice|TTC23_uc002buz.2_Intron	NM_022905	NP_075056	Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23								binding				0	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			AGGTTGCTCTCTGTGAAAGGA	0.488			NA											15	50					0	0	0.003163	0	0
ZNF597	146434	broad.mit.edu	37	16	3490921	3490921	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr16:3490921A>G	uc002cvd.2	-	3	230	c.46T>C	c.(46-48)TTT>CTT	p.F16L	NAT15_uc002cvh.3_5'Flank|NAT15_uc010uxb.1_5'Flank	NM_152457	NP_689670	Q96LX8	ZN597_HUMAN	zinc finger protein 597	16	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGATCCTCAAAGAGTATTGGT	0.498			NA											16	110					0	0	0.003163	0	0
C16orf45	89927	broad.mit.edu	37	16	15677017	15677017	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr16:15677017C>A	uc002ddo.2	+	5	610	c.424C>A	c.(424-426)CAA>AAA	p.Q142K	C16orf45_uc002ddp.2_Missense_Mutation_p.Q125K	NM_033201	NP_149978	Q96MC5	CP045_HUMAN	hypothetical protein LOC89927 isoform 1	142										ovary(1)	1						TCACAGGGAGCAAGAAGAAGA	0.378			NA											44	224					3.05275e-18	3.68268e-18	0.003214	1	0
Unknown	0	broad.mit.edu	37	16	28354090	28354090	+	Silent	SNP	C	C	G	rs609553	by1000genomes	TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr16:28354090C>G	uc010vcq.1	-	7	1115	c.1062G>C	c.(1060-1062)CCG>CCC	p.P354P	uc010vcr.1_Silent_p.P372P					SubName: Full=LOC728741 protein;												NA						TCTTGGGTTTCGGTGATTGTT	0.254			NA											4	8					0	0	0.009096	0	0
ZNF668	79759	broad.mit.edu	37	16	31073109	31073109	+	Silent	SNP	C	C	T	rs144972780	byFrequency	TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr16:31073109C>T	uc010caf.2	-	3	1497	c.1140G>A	c.(1138-1140)ACG>ACA	p.T380T	ZNF668_uc002eao.2_Silent_p.T380T	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	380	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						GGCTATGCTTCGTGAGGCTGG	0.672	Colon(181;1111 1980 5060 10512 25785)		NA											36	320					0	0	0.004289	0	0
PHKB	5257	broad.mit.edu	37	16	47723058	47723058	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr16:47723058G>C	uc002eev.3	+	27	2789	c.2737G>C	c.(2737-2739)GAT>CAT	p.D913H	PHKB_uc002eeu.3_Missense_Mutation_p.D906H|PHKB_uc002eew.3_Missense_Mutation_p.D154H	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	913					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				GCTTCTGCTGGATATTCTGCA	0.428			NA											23	108					0	0	0.002299	0	0
N4BP1	9683	broad.mit.edu	37	16	48594762	48594762	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr16:48594762C>T	uc002efp.2	-	2	2029	c.1792G>A	c.(1792-1794)GAT>AAT	p.D598N		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	598					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)				TTTAGAGTATCTCGAAACCTT	0.423			NA											23	236					0	0	0.00278	0	0
CNOT1	23019	broad.mit.edu	37	16	58580600	58580600	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr16:58580600C>T	uc002env.2	-	28	4097	c.3804G>A	c.(3802-3804)GAG>GAA	p.E1268E	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Silent_p.E1263E|CNOT1_uc002enx.2_Silent_p.E1268E|CNOT1_uc010vik.1_Silent_p.E225E	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1268					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CCTGATGTAGCTCAGCTAATA	0.388			NA											7	106					0	0	0.00308	0	0
RRAD	6236	broad.mit.edu	37	16	66958740	66958740	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr16:66958740C>G	uc002eqn.2	-	2	495	c.343G>C	c.(343-345)GAG>CAG	p.E115Q	RRAD_uc002eqo.2_Missense_Mutation_p.E115Q	NM_001128850	NP_001122322	P55042	RAD_HUMAN	Ras-related associated with diabetes	115					small GTPase mediated signal transduction	plasma membrane	calmodulin binding|GTP binding|GTPase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0862)|Epithelial(162;0.198)		GGCCCGTCCTCCACACCGCCG	0.682			NA											5	43					0	0	0.001168	0	0
TSNAXIP1	55815	broad.mit.edu	37	16	67854848	67854848	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr16:67854848G>T	uc002euj.2	+	3	486	c.92G>T	c.(91-93)CGA>CTA	p.R31L	TSNAXIP1_uc010cep.2_5'UTR|TSNAXIP1_uc010vjz.1_Intron|TSNAXIP1_uc002euf.3_Intron|TSNAXIP1_uc010vka.1_Missense_Mutation_p.R85L|TSNAXIP1_uc010vkb.1_Intron|TSNAXIP1_uc002eug.3_Intron|TSNAXIP1_uc002euh.3_Intron|TSNAXIP1_uc002eui.3_Intron|TSNAXIP1_uc002euk.2_5'Flank	NM_018430	NP_060900	Q2TAA8	TXIP1_HUMAN	translin-associated factor X interacting protein	31					cell differentiation|multicellular organismal development|spermatogenesis	perinuclear region of cytoplasm					0		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00432)|Epithelial(162;0.0192)|all cancers(182;0.125)		TACCGGAAGCGAGTAGGGTAA	0.597			NA											54	351					2.01807e-28	2.48378e-28	0.00361	1	0
LCAT	3931	broad.mit.edu	37	16	67976321	67976321	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr16:67976321G>C	uc002euy.1	-	5	704	c.693C>G	c.(691-693)ATC>ATG	p.I231M		NM_000229	NP_000220	P04180	LCAT_HUMAN	lecithin-cholesterol acyltransferase precursor	231					cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|reverse cholesterol transport|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein A-I binding|phosphatidylcholine-sterol O-acyltransferase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00418)|Epithelial(162;0.0183)|all cancers(182;0.12)		CCCCAAGAGAGATGAAGCCAT	0.582			NA											12	95					0	0	0.000978	0	0
PDPR	55066	broad.mit.edu	37	16	70190452	70190452	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr16:70190452C>T	uc002eyf.1	+	19	3267	c.2310C>T	c.(2308-2310)TTC>TTT	p.F770F	CLEC18C_uc002exy.2_Intron|PDPR_uc010vlr.1_Silent_p.F670F|PDPR_uc002eyg.1_Silent_p.F437F|PDPR_uc002eyh.2_Silent_p.F115F|PDPR_uc010vls.1_Silent_p.F115F	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory	770					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.124)		TCACCATGTTCATCCTGGACG	0.532			NA											61	262					0	0	0.00361	0	0
ZFHX3	463	broad.mit.edu	37	16	72821294	72821294	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr16:72821294C>T	uc002fck.2	-	10	11554	c.10881G>A	c.(10879-10881)GCG>GCA	p.A3627A	uc002fcj.1_Intron|ZFHX3_uc002fcl.2_Silent_p.A2713A	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3627					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				AAGGGGGCTTCGCTGCCGAAG	0.637			NA											15	39					0	0	0.00499	0	0
BCAR1	9564	broad.mit.edu	37	16	75263784	75263784	+	Silent	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr16:75263784G>A	uc002fdv.2	-	7	2361	c.2238C>T	c.(2236-2238)TTC>TTT	p.F746F	BCAR1_uc002fdt.2_Silent_p.F199F|BCAR1_uc002fdu.2_Silent_p.F536F|BCAR1_uc010cgu.2_Silent_p.F735F|BCAR1_uc010vna.1_Silent_p.F744F|BCAR1_uc010vnb.1_Silent_p.F792F|BCAR1_uc002fdw.2_Silent_p.F746F|BCAR1_uc010vnc.1_Silent_p.F598F|BCAR1_uc010vnd.1_Silent_p.F764F|BCAR1_uc002fdx.2_Silent_p.F764F	NM_014567	NP_055382	P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	746	Divergent helix-loop-helix motif.				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			central_nervous_system(5)|breast(2)|prostate(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.169)		GCTCCAGGTAGAAGAGCAGCA	0.672			NA											18	75					0	0	0.008871	0	0
TP53	7157	broad.mit.edu	37	17	7577099	7577099	+	Missense_Mutation	SNP	C	C	G	rs121912660		TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr17:7577099C>G	uc002gim.2	-	8	1033	c.839G>C	c.(838-840)AGA>ACA	p.R280T	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R280T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R148T|TP53_uc010cng.1_Missense_Mutation_p.R148T|TP53_uc002gii.1_Missense_Mutation_p.R148T|TP53_uc010cnh.1_Missense_Mutation_p.R280T|TP53_uc010cni.1_Missense_Mutation_p.R280T|TP53_uc002gij.2_Missense_Mutation_p.R280T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	280	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> T (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(53)|p.R280K(41)|p.R280G(18)|p.R280S(13)|p.R280I(12)|p.R280*(8)|p.R280fs*65(7)|p.0?(7)|p.R280R(3)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.G279_R280delGR(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.D281fs*24(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	53					0	0	0.007413	0	0
FLCN	201163	broad.mit.edu	37	17	17122443	17122443	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr17:17122443C>A	uc002gra.3	-	9	1456	c.952G>T	c.(952-954)GAA>TAA	p.E318*	PLD6_uc010cpn.2_Intron	NM_144997	NP_659434	Q8NFG4	FLCN_HUMAN	folliculin isoform 1	318					regulation of protein phosphorylation	cytoplasm|nucleus|plasma membrane	protein binding			thyroid(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)	3						TCCCGCCCTTCTGTACTCTCT	0.587			NA							Birt-Hogg-Dub__syndrome|Familial_Non-VHL_Clear_Cell_Renal_Cancer				75	290					6.0678e-26	7.43794e-26	0.00361	1	0
LGALS9	3965	broad.mit.edu	37	17	25967714	25967714	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr17:25967714G>T	uc002gzp.2	+	3	366	c.248G>T	c.(247-249)GGG>GTG	p.G83V	LGALS9_uc002gzq.2_Missense_Mutation_p.G83V|LGALS9_uc002gzr.2_Missense_Mutation_p.G26V|LGALS9_uc010waa.1_Missense_Mutation_p.G26V|LGALS9_uc002gzs.2_Missense_Mutation_p.G83V	NM_009587	NP_033665	O00182	LEG9_HUMAN	galectin-9 isoform long	83	Galectin 1.|Beta-galactoside binding 1.				positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	galactose binding|signal transducer activity				0	Lung NSC(42;0.0103)		BRCA - Breast invasive adenocarcinoma(3;0.0141)	UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		GGAAGCTGGGGGCCCGAGGAG	0.547	Melanoma(106;677 1527 28724 29571 46552)|Ovarian(193;263 2088 2118 29005 43023)		NA											57	255					7.73544e-29	9.59827e-29	0.00361	1	0
CRHR1	1394	broad.mit.edu	37	17	43912048	43912048	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr17:43912048C>A	uc010dap.2	+	14	1518	c.1253C>A	c.(1252-1254)GCC>GAC	p.A418D	CRHR1_uc010wjx.1_Missense_Mutation_p.A214D|CRHR1_uc002ijp.2_Missense_Mutation_p.P243T|CRHR1_uc002ijm.2_Missense_Mutation_p.A389D|CRHR1_uc002ijn.2_Missense_Mutation_p.A349D|CRHR1_uc010dar.2_Missense_Mutation_p.A375D|CRHR1_uc010dao.2_Missense_Mutation_p.A288D|CRHR1_uc010daq.2_Missense_Mutation_p.A214D	NM_001145146	NP_001138618	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	418	Cytoplasmic (Potential).				female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(3)	3	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		TCGATCCGTGCCCGAGTGGCC	0.632	Ovarian(110;57 1568 10207 38216 49865)		NA											9	103					0.00829132	0.00857334	0.008291	1	0
HOXB1	3211	broad.mit.edu	37	17	46608134	46608134	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr17:46608134C>T	uc002ink.1	-	1	139	c.133G>A	c.(133-135)GAG>AAG	p.E45K		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	45						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TAGCGGCCCTCGCTTGCATAG	0.682			NA											38	109					0	0	0.00623	0	0
BCAS3	54828	broad.mit.edu	37	17	58946004	58946004	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr17:58946004C>G	uc002iyv.3	+	8	653	c.544C>G	c.(544-546)CAA>GAA	p.Q182E	BCAS3_uc010wow.1_Intron|BCAS3_uc002iyu.3_Missense_Mutation_p.Q182E|BCAS3_uc002iyw.3_Missense_Mutation_p.Q178E	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	182						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			CAAGTCCATTCAATTTAAGAC	0.373			NA											23	81					0	0	0.00632	0	0
TLK2	11011	broad.mit.edu	37	17	60613585	60613585	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr17:60613585A>G	uc010ddp.2	+	7	686	c.418A>G	c.(418-420)ACG>GCG	p.T140A	TLK2_uc002izx.3_5'UTR|TLK2_uc002izz.3_Missense_Mutation_p.T140A|TLK2_uc002jaa.3_Missense_Mutation_p.T108A|TLK2_uc010wpd.1_Missense_Mutation_p.T108A	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	140					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						AAAGGAGGCAACGGAGGAGCA	0.512			NA											18	75					0	0	0.006122	0	0
CACNG4	27092	broad.mit.edu	37	17	65027117	65027117	+	Silent	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr17:65027117G>T	uc002jft.1	+	4	996	c.981G>T	c.(979-981)GTG>GTT	p.V327V		NM_014405	NP_055220	Q9UBN1	CCG4_HUMAN	voltage-dependent calcium channel gamma-4	327	Cytoplasmic (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)	1	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			CGACCCCTGTGTGAGCCGCCT	0.572			NA											23	106					3.28513e-13	3.81175e-13	0.003954	1	0
FAM20A	54757	broad.mit.edu	37	17	66533706	66533706	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr17:66533706A>G	uc002jho.2	-	11	1826	c.1538T>C	c.(1537-1539)ATA>ACA	p.I513T	FAM20A_uc010wqp.1_Missense_Mutation_p.I375T|PRKAR1A_uc002jhm.2_Intron|FAM20A_uc002jhn.2_Missense_Mutation_p.I224T	NM_017565	NP_060035	Q96MK3	FA20A_HUMAN	family with sequence similarity 20, member A	513						extracellular region					0	Breast(10;1.64e-13)					ATGGGCCACTATGCACCCCTC	0.587			NA											3	81					0	0	0.004672	0	0
SMAD4	4089	broad.mit.edu	37	18	48575671	48575671	+	Nonsense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr18:48575671C>G	uc010xdp.1	+	4	969	c.431C>G	c.(430-432)TCA>TGA	p.S144*	SMAD4_uc010xdo.1_RNA	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	144					BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(4)|p.S144*(2)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		TAAGATCTCTCAGGATTAACA	0.294			NA							Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				12	45					0	0	0.00245	0	0
MUC16	94025	broad.mit.edu	37	19	9068944	9068944	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr19:9068944C>G	uc002mkp.2	-	3	18706	c.18502G>C	c.(18502-18504)GGC>CGC	p.G6168R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6170	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCAGTTGGCCAAGAGATGTC	0.488			NA											23	76					0	0	0.002299	0	0
CD97	976	broad.mit.edu	37	19	14507264	14507264	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr19:14507264G>C	uc002myl.2	+	5	580	c.457G>C	c.(457-459)GAG>CAG	p.E153Q	CD97_uc002mym.2_Missense_Mutation_p.E153Q|CD97_uc002myn.2_Intron	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	153	Extracellular (Potential).|EGF-like 3; calcium-binding (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						GTTCATACCTGAGGATCCGAA	0.597			NA											14	80					0	0	0.00278	0	0
OR7A5	26659	broad.mit.edu	37	19	14938176	14938176	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr19:14938176C>A	uc002mzw.2	-	1	1101	c.878G>T	c.(877-879)AGG>ATG	p.R293M	OR7A5_uc010xoa.1_Missense_Mutation_p.R293M	NM_017506	NP_059976	Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)	2						GTCTTTATTCCTCAGACTATA	0.468			NA											25	89					5.61819e-17	6.72413e-17	0.005443	1	0
MAST3	23031	broad.mit.edu	37	19	18255868	18255868	+	Silent	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr19:18255868G>T	uc002nhz.3	+	23	2781	c.2781G>T	c.(2779-2781)TCG>TCT	p.S927S		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	927	Ser-rich.						ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						CTCTGTCCTCGAACCCGTCGT	0.667			NA											15	45					1.49906e-05	1.63926e-05	0.00245	1	0
TSHZ3	57616	broad.mit.edu	37	19	31768409	31768409	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr19:31768409C>A	uc002nsy.3	-	2	2355	c.2290G>T	c.(2290-2292)GCC>TCC	p.A764S		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	764					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					GGCGGGGTGGCCACAGCAGCC	0.602			NA											14	242					3.45872e-05	3.74182e-05	0.004007	1	0
ZNF507	22847	broad.mit.edu	37	19	32844370	32844370	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr19:32844370C>G	uc002nte.2	+	3	906	c.634C>G	c.(634-636)CCA>GCA	p.P212A	ZNF507_uc002ntc.2_Missense_Mutation_p.P212A|ZNF507_uc010xrn.1_Missense_Mutation_p.P212A|ZNF507_uc002ntd.2_Missense_Mutation_p.P212A	NM_001136156	NP_001129628	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	212					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|kidney(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(110;0.162)					TGAAACCATTCCAGATATCCC	0.453			NA											19	195					0	0	0.006122	0	0
GPATCH1	55094	broad.mit.edu	37	19	33581687	33581687	+	Silent	SNP	A	A	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr19:33581687A>G	uc002nug.1	+	3	524	c.210A>G	c.(208-210)GGA>GGG	p.G70G		NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	70						catalytic step 2 spliceosome	nucleic acid binding			skin(1)	1	Esophageal squamous(110;0.137)					TTTTTTCAGGATGGACACCCT	0.373	Pancreas(67;88 1713 4567 18227)		NA											9	152					0	0	0.008291	0	0
GPATCH1	55094	broad.mit.edu	37	19	33600726	33600726	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr19:33600726G>T	uc002nug.1	+	11	1703	c.1389G>T	c.(1387-1389)AGG>AGT	p.R463S		NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	463						catalytic step 2 spliceosome	nucleic acid binding			skin(1)	1	Esophageal squamous(110;0.137)					TCAAGGCCAGGAGTCTGGCCC	0.542	Pancreas(67;88 1713 4567 18227)		NA											26	246					1.04121e-07	1.15521e-07	0.005443	1	0
SBSN	374897	broad.mit.edu	37	19	36017721	36017721	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr19:36017721C>A	uc002oae.1	-	2	504	c.434G>T	c.(433-435)GGG>GTG	p.G145V	SBSN_uc002oad.1_Missense_Mutation_p.G488V	NM_198538	NP_940940	Q6UWP8	SBSN_HUMAN	suprabasin isoform 2 precursor	145	Ala/Gly/His-rich.					extracellular region				ovary(1)	1	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TGCTTCCTTCCCAGCCTGGTG	0.597			NA											23	152					1.22574e-08	1.39039e-08	0.002299	1	0
RYR1	6261	broad.mit.edu	37	19	39025783	39025783	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr19:39025783G>C	uc002oit.2	+	80	11492	c.11362G>C	c.(11362-11364)GAG>CAG	p.E3788Q	RYR1_uc002oiu.2_Missense_Mutation_p.E3783Q|RYR1_uc002oiv.1_Missense_Mutation_p.E703Q|RYR1_uc010xuf.1_Missense_Mutation_p.E708Q	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3788					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCCTCCAGGAGAGACAGGTGC	0.557			NA											13	109					0	0	0.001855	0	0
ZNF546	339327	broad.mit.edu	37	19	40519640	40519640	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr19:40519640C>G	uc002oms.2	+	7	719	c.463C>G	c.(463-465)CAA>GAA	p.Q155E	ZNF546_uc002omt.2_Missense_Mutation_p.Q129E	NM_178544	NP_848639	Q86UE3	ZN546_HUMAN	zinc finger protein 546	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CTATTTATCTCAATTGCAGAC	0.313			NA											21	211					0	0	0.010504	0	0
AKT2	208	broad.mit.edu	37	19	40745964	40745964	+	Silent	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr19:40745964G>A	uc002onf.2	-	7	889	c.627C>T	c.(625-627)CAC>CAT	p.H209H	AKT2_uc010egs.2_Silent_p.H209H|AKT2_uc010egt.2_Silent_p.H147H|AKT2_uc010xvj.1_Silent_p.H147H|AKT2_uc010egu.1_Silent_p.H147H|AKT2_uc010xvk.1_Silent_p.H209H|AKT2_uc002one.2_Silent_p.H105H	NM_001626	NP_001617	P31751	AKT2_HUMAN	AKT2 kinase	209	Protein kinase.				insulin receptor signaling pathway|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2			Lung(22;0.000499)			TGAGGAACGGGTGCCTGGTGT	0.597			NA	A		ovarian|pancreatic 								32	866					0	0	0.002096	0	0
LTBP4	8425	broad.mit.edu	37	19	41105459	41105459	+	Missense_Mutation	SNP	T	T	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr19:41105459T>G	uc002ooh.1	+	3	338	c.338T>G	c.(337-339)CTG>CGG	p.L113R	LTBP4_uc002oog.1_Missense_Mutation_p.L76R|LTBP4_uc002ooi.1_5'Flank	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	113					growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGGCAGCCACTGACGTGAGTG	0.537			NA											43	379					0	0	0.00361	0	0
DMPK	1760	broad.mit.edu	37	19	46283154	46283154	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr19:46283154C>A	uc002pdd.1	-	1	708	c.164G>T	c.(163-165)CGG>CTG	p.R55L	DMPK_uc010xxs.1_5'Flank|DMPK_uc002pde.1_Missense_Mutation_p.R55L|DMPK_uc002pdf.1_Intron|DMPK_uc002pdg.1_Intron|DMPK_uc002pdh.1_Intron|DMPK_uc002pdi.1_Intron|DMPK_uc010xxt.1_Intron|DMPK_uc010xxu.1_Missense_Mutation_p.R55L	NM_001081563	NP_001075032	Q09013	DMPK_HUMAN	myotonic dystrophy protein kinase isoform 1	55					regulation of heart contraction		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)	3		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00616)|GBM - Glioblastoma multiforme(486;0.0825)|Epithelial(262;0.24)		GGAAAAGAACCGAGGGTCACC	0.602	Esophageal Squamous(35;307 869 9153 24033 28903)		NA											16	61					5.03518e-11	5.77621e-11	0.007413	1	0
BAX	581	broad.mit.edu	37	19	49459574	49459574	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr19:49459574G>T	uc002plk.2	+	4	422	c.353G>T	c.(352-354)AGC>ATC	p.S118I	BAX_uc002plf.1_Missense_Mutation_p.S118I|BAX_uc002plg.1_Missense_Mutation_p.S81I|BAX_uc002plh.1_Missense_Mutation_p.S40I|BAX_uc010xzx.1_RNA|BAX_uc002plj.2_Missense_Mutation_p.S118I|BAX_uc002pll.2_Missense_Mutation_p.S69I|BAX_uc002plm.2_Missense_Mutation_p.S40I	NM_138761	NP_620116	Q07812	BAX_HUMAN	BCL2-associated X protein isoform alpha	118	BH1.				activation of caspase activity by cytochrome c|activation of pro-apoptotic gene products|B cell apoptosis|cleavage of lamin|DNA fragmentation involved in apoptotic nuclear change|establishment or maintenance of transmembrane electrochemical gradient|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|induction of retinal programmed cell death|mitochondrial fragmentation involved in apoptosis|mitochondrial fusion|negative regulation of protein binding|negative regulation of survival gene product expression|nuclear fragmentation involved in apoptotic nuclear change|positive regulation of neuron apoptosis|protein homooligomerization|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|release of cytochrome c from mitochondria|release of matrix enzymes from mitochondria|response to toxin|transformed cell apoptosis	cytosol|endoplasmic reticulum membrane|mitochondrial outer membrane|mitochondrial permeability transition pore complex|nucleus	BH3 domain binding|channel activity|lipid binding|protein heterodimerization activity|protein homodimerization activity			lung(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000159)|all cancers(93;0.00047)|GBM - Glioblastoma multiforme(486;0.018)|Epithelial(262;0.0279)		TACTTTGCCAGCAAACTGGTG	0.587			NA											30	99					7.26314e-15	8.62498e-15	0.007291	1	0
ZNF616	90317	broad.mit.edu	37	19	52619760	52619760	+	Silent	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr19:52619760G>T	uc002pym.2	-	4	940	c.657C>A	c.(655-657)GGC>GGA	p.G219G	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	219	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		GAAAGGCTTTGCCACACTCAT	0.393			NA											6	175					3.59834e-05	3.87906e-05	0.001168	1	0
FIZ1	84922	broad.mit.edu	37	19	56104103	56104103	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr19:56104103C>T	uc002qli.3	-	3	1294	c.1204G>A	c.(1204-1206)GAA>AAA	p.E402K	FIZ1_uc002qlj.3_Missense_Mutation_p.E402K	NM_032836	NP_116225	Q96SL8	FIZ1_HUMAN	FLT3-interacting zinc finger 1	402					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein kinase binding|receptor binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		GACGGGGGTTCCCCGGACGCC	0.736			NA											6	55					0	0	0.004482	0	0
NLRP13	126204	broad.mit.edu	37	19	56423835	56423835	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr19:56423835G>C	uc010ygg.1	-	5	1373	c.1348C>G	c.(1348-1350)CAG>GAG	p.Q450E		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	450	NACHT.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GTGGTAGTCTGAGTGATTGAC	0.502			NA											18	121					0	0	0.010504	0	0
PREPL	9581	broad.mit.edu	37	2	44569580	44569580	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:44569580C>T	uc002ruf.2	-	5	763	c.728G>A	c.(727-729)CGC>CAC	p.R243H	PREPL_uc002rug.2_Missense_Mutation_p.R243H|PREPL_uc002ruh.2_Missense_Mutation_p.R243H|PREPL_uc010fax.2_Missense_Mutation_p.R243H|PREPL_uc002rui.3_Missense_Mutation_p.R154H|PREPL_uc002ruj.1_Missense_Mutation_p.R154H|PREPL_uc002ruk.1_Missense_Mutation_p.R243H	NM_006036	NP_006027	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like isoform C	243					proteolysis	cytosol	serine-type endopeptidase activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TGTGTAAAAGCGTTCATTACG	0.378			NA											39	117					0	0	0.003214	0	0
EPAS1	2034	broad.mit.edu	37	2	46608818	46608818	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:46608818G>A	uc002ruv.2	+	13	2617	c.2129G>A	c.(2128-2130)CGA>CAA	p.R710Q	EPAS1_uc002ruw.2_Missense_Mutation_p.R176Q	NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	710					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			AAGCTGAAGCGACAGCTGGAG	0.617			NA											17	106					0	0	0.006122	0	0
CCDC88A	55704	broad.mit.edu	37	2	55546020	55546020	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:55546020C>T	uc002ryv.2	-	19	4122	c.3280G>A	c.(3280-3282)GAA>AAA	p.E1094K	CCDC88A_uc010yoz.1_Missense_Mutation_p.E1095K|CCDC88A_uc010ypa.1_Missense_Mutation_p.E1094K|CCDC88A_uc002ryu.2_Missense_Mutation_p.E377K|CCDC88A_uc002rys.2_Missense_Mutation_p.E80K|CCDC88A_uc002ryw.2_Missense_Mutation_p.E378K|CCDC88A_uc010fby.1_5'UTR	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	1095	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						GTATTCTGTTCTTGTAATGAC	0.368			NA											31	170					0	0	0.002445	0	0
USP34	9736	broad.mit.edu	37	2	61538783	61538783	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:61538783G>C	uc002sbe.2	-	27	3731	c.3709C>G	c.(3709-3711)CTT>GTT	p.L1237V		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	1237					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			TCAGCCCTAAGATCTGCTACC	0.353			NA											9	94					0	0	0.006214	0	0
FBXO41	150726	broad.mit.edu	37	2	73486384	73486384	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:73486384C>T	uc002sjb.1	-	12	2673	c.2673G>A	c.(2671-2673)GGG>GGA	p.G891G		NM_001080410	NP_001073879	Q8TF61	FBX41_HUMAN	F-box protein 41	830						intracellular	protein binding|zinc ion binding			breast(2)|pancreas(1)	3						AATCCGCAATCCCAATCTGGA	0.557			NA											14	113					0	0	0.00245	0	0
C2orf78	388960	broad.mit.edu	37	2	74042320	74042320	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:74042320G>C	uc002sjr.1	+	3	1091	c.970G>C	c.(970-972)GAG>CAG	p.E324Q		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	324										ovary(2)	2						CCAGACACTTGAGAGTAACCC	0.463			NA											25	83					0	0	0.005443	0	0
ANAPC1	64682	broad.mit.edu	37	2	112604723	112604723	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:112604723G>C	uc002thi.2	-	16	2091	c.1844C>G	c.(1843-1845)TCT>TGT	p.S615C		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	615					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						ACCTAACTCAGAGGTGGCAAT	0.328			NA											6	88					0	0	0.001984	0	0
RGPD5	84220	broad.mit.edu	37	2	113190977	113190977	+	Silent	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:113190977G>A	uc002ths.1	-	1	131	c.54C>T	c.(52-54)CTC>CTT	p.L18L	RGPD8_uc010fkk.1_Intron|RGPD5_uc010yxm.1_Silent_p.L18L	NM_005054	NP_005045	Q99666	RGPD5_HUMAN	RANBP2-like and GRIP domain containing 5 isoform	18					intracellular transport	cytoplasm	binding				0						GCGACGGGGTGAGACCCAGCA	0.547			NA											4	40					0	0	0.000602	0	0
IWS1	55677	broad.mit.edu	37	2	128263325	128263325	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:128263325C>A	uc002ton.2	-	3	457	c.154G>T	c.(154-156)GAA>TAA	p.E52*	IWS1_uc010yzl.1_RNA|IWS1_uc010fma.2_RNA	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	52					transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		TCACTAGTTTCATTCTGAAAA	0.308			NA											20	210					1.00905e-13	1.18436e-13	0.008871	1	0
RIF1	55183	broad.mit.edu	37	2	152295239	152295239	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:152295239G>A	uc002txm.2	+	14	1655	c.1525G>A	c.(1525-1527)GTG>ATG	p.V509M	RIF1_uc002txl.2_Missense_Mutation_p.V509M|RIF1_uc010fnv.1_Missense_Mutation_p.V473M|RIF1_uc002txn.2_Missense_Mutation_p.V509M|RIF1_uc002txo.2_Missense_Mutation_p.V509M|RIF1_uc010zby.1_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	509					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		AATTAGCTTGGTGAAGTCAGT	0.348			NA											18	63					0	0	0.007413	0	0
SLC38A11	151258	broad.mit.edu	37	2	165755217	165755217	+	Silent	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:165755217G>T	uc002ucv.1	-	13	1488	c.951C>A	c.(949-951)CTC>CTA	p.L317L	SLC38A11_uc002ucu.1_Silent_p.L295L|SLC38A11_uc002ucw.1_Silent_p.L317L	NM_173512	NP_775783	Q08AI6	S38AB_HUMAN	solute carrier family 38, member 11	317	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				ovary(1)	1						TGATAAAAATGAGGGGAGTTG	0.408			NA											5	74					0.000602214	0.000629117	0.000602	1	0
DHRS9	10170	broad.mit.edu	37	2	169938312	169938312	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:169938312C>T	uc002uep.2	+	5	1725	c.221C>T	c.(220-222)TCA>TTA	p.S74L	DHRS9_uc002ueq.2_Missense_Mutation_p.S74L|DHRS9_uc010zdc.1_Missense_Mutation_p.S134L|DHRS9_uc002uer.1_Missense_Mutation_p.S74L|DHRS9_uc010zdd.1_Missense_Mutation_p.S74L|DHRS9_uc010zde.1_Missense_Mutation_p.S74L	NM_005771	NP_005762	Q9BPW9	DHRS9_HUMAN	NADP-dependent retinol dehydrogenase/reductase	74					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity				0						GCAGAAACCTCAGAGAGACTT	0.468			NA											11	89					0	0	0.008291	0	0
TTN	7273	broad.mit.edu	37	2	179605502	179605502	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:179605502T>A	uc010zfh.1	-	46	12169	c.11945A>T	c.(11944-11946)CAG>CTG	p.Q3982L	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.Q3915L|TTN_uc010zfj.1_Missense_Mutation_p.Q3790L|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTACAATCTGCAGCTGTAG	0.458			NA											50	207					0	0	0.00361	0	0
PLCL1	5334	broad.mit.edu	37	2	198949863	198949863	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:198949863G>T	uc010fsp.2	+	2	1913	c.1622G>T	c.(1621-1623)GGA>GTA	p.G541V	PLCL1_uc002uuv.3_Missense_Mutation_p.G462V	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	541	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	ATTGTGAAAGGAAAGAAGTTG	0.388			NA											10	93					1.76689e-08	1.98205e-08	0.006214	1	0
C2orf47	79568	broad.mit.edu	37	2	200824033	200824033	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:200824033G>C	uc002uvm.2	+	3	815	c.493G>C	c.(493-495)GAT>CAT	p.D165H		NM_024520	NP_078796	Q8WWC4	CB047_HUMAN	hypothetical protein LOC79568 precursor	165						mitochondrion					0						GTGTAAATTTGATCTGTTGGA	0.323			NA											18	136					0	0	0.008871	0	0
CPS1	1373	broad.mit.edu	37	2	211542708	211542708	+	Nonstop_Mutation	SNP	A	A	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:211542708A>G	uc002vee.3	+	38	4634	c.4502A>G	c.(4501-4503)TAG>TGG	p.*1501W	CPS1_uc010fur.2_Nonstop_Mutation_p.*1507W|CPS1_uc010fus.2_Nonstop_Mutation_p.*1050W	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1501					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		AAAGCAGCATAGAGATGCAGA	0.433			NA											51	204					0	0	0.00361	0	0
ABCA12	26154	broad.mit.edu	37	2	215919366	215919366	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:215919366T>A	uc002vew.2	-	4	560	c.340A>T	c.(340-342)AAC>TAC	p.N114Y	ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	114					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TTATCCAGGTTGGATGACTTT	0.393	Ovarian(66;664 1488 5121 34295)		NA											27	231					0	0	0.00632	0	0
OBSL1	23363	broad.mit.edu	37	2	220432056	220432056	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:220432056G>C	uc010fwk.2	-	4	1833	c.1776C>G	c.(1774-1776)ATC>ATG	p.I592M	OBSL1_uc010fwl.1_Missense_Mutation_p.I67M|OBSL1_uc002vmi.2_Missense_Mutation_p.I592M|OBSL1_uc002vmj.2_Missense_Mutation_p.I179M	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	592	Fibronectin type-III.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		TGACTGTGCAGATGCGGAAGC	0.612			NA											4	27					0	0	0.009096	0	0
SP140	11262	broad.mit.edu	37	2	231109762	231109762	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr2:231109762G>A	uc002vql.2	+	6	746	c.631G>A	c.(631-633)GAA>AAA	p.E211K	SP140_uc010zma.1_RNA|SP140_uc002vqk.2_Missense_Mutation_p.E211K|SP140_uc002vqn.2_Missense_Mutation_p.E211K|SP140_uc002vqm.2_Missense_Mutation_p.E211K|SP140_uc010fxl.2_Missense_Mutation_p.E211K	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	211					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGGAGATGCTGAAGATGCACC	0.448			NA											9	94					0	0	0.000978	0	0
DSTN	11034	broad.mit.edu	37	20	17581487	17581487	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr20:17581487C>T	uc002wpr.2	+	2	363	c.108C>T	c.(106-108)GTC>GTT	p.V36V	DSTN_uc002wpq.2_Silent_p.V19V|DSTN_uc010gck.2_Silent_p.V19V	NM_006870	NP_006861	P60981	DEST_HUMAN	destrin isoform a	36	ADF-H.				actin filament severing|actin polymerization or depolymerization		actin binding			large_intestine(1)|skin(1)	2						AGAAGGCTGTCATTTTTTGTC	0.393			NA											34	78					0	0	0.002836	0	0
MYLK2	85366	broad.mit.edu	37	20	30418929	30418929	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr20:30418929T>C	uc002wwq.2	+	10	1511	c.1409T>C	c.(1408-1410)GTG>GCG	p.V470A	MYLK2_uc002wws.2_Missense_Mutation_p.V87A|MYLK2_uc010gdw.1_RNA	NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	470	Protein kinase.				cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AGTATGGGGGTGATCACCTAC	0.567			NA											40	143					0	0	0.003214	0	0
MOCS3	27304	broad.mit.edu	37	20	49575979	49575979	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr20:49575979C>T	uc002xvy.1	+	1	617	c.600C>T	c.(598-600)CTC>CTT	p.L200L	DPM1_uc002xvw.1_5'Flank|DPM1_uc002xvx.1_5'Flank	NM_014484	NP_055299	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	200					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			skin(2)|ovary(1)	3						GTCGGCCCCTCGTGTCTGCCA	0.602			NA											19	79					0	0	0.006122	0	0
CHRNA4	1137	broad.mit.edu	37	20	61982028	61982028	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr20:61982028G>T	uc002yes.2	-	5	913	c.735C>A	c.(733-735)TTC>TTA	p.F245L	CHRNA4_uc002yet.1_Missense_Mutation_p.F69L|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Missense_Mutation_p.F174L|CHRNA4_uc002yev.1_Missense_Mutation_p.F69L|CHRNA4_uc010gkf.1_Missense_Mutation_p.F69L	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	245	Helical; (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	TGATGGTGTAGAAGAGCGGCA	0.592			NA											13	58					1.67942e-08	1.8909e-08	0.006122	1	0
RTEL1	51750	broad.mit.edu	37	20	62321110	62321110	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr20:62321110C>G	uc002yfu.1	+	24	2376	c.2033C>G	c.(2032-2034)TCT>TGT	p.S678C	RTEL1_uc011abc.1_RNA|RTEL1_uc002yft.1_Missense_Mutation_p.S678C|RTEL1_uc011abd.1_Missense_Mutation_p.S702C|RTEL1_uc011abe.1_Missense_Mutation_p.S455C|RTEL1_uc002yfw.2_RNA|RTEL1_uc002yfx.1_5'UTR	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	678					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			CAGTTCCTCTCTGGGCAGGAG	0.697			NA											4	55					0	0	0.001168	0	0
PCMTD2	55251	broad.mit.edu	37	20	62896764	62896764	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr20:62896764C>T	uc002yil.3	+	4	764	c.564C>T	c.(562-564)GTC>GTT	p.V188V	PCMTD2_uc002yim.3_Silent_p.V188V	NM_018257	NP_060727	Q9NV79	PCMD2_HUMAN	protein-L-isoaspartate (D-aspartate)	188						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GGATCCTTGTCATGCCACTGG	0.318			NA											20	100					0	0	0.007413	0	0
KRTAP23-1	337963	broad.mit.edu	37	21	31720897	31720897	+	Missense_Mutation	SNP	A	A	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr21:31720897A>C	uc002yny.1	-	1	28	c.28T>G	c.(28-30)TTC>GTC	p.F10V		NM_181624	NP_853655	A1A580	KR231_HUMAN	keratin associated protein 23-1	10						intermediate filament					0						TGGGAGGAGAAGTTTCCACAG	0.537			NA											7	98					0	0	0.00308	0	0
C22orf36	388886	broad.mit.edu	37	22	24985872	24985872	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr22:24985872C>G	uc003aaq.2	-	2	252	c.223G>C	c.(223-225)GAT>CAT	p.D75H	GGT1_uc003aan.1_Intron|C22orf36_uc003aao.2_5'Flank|C22orf36_uc003aap.2_RNA	NM_207644	NP_997527	Q2VPJ9	LRC6X_HUMAN	hypothetical protein LOC388886	75											0						AAGGCCACATCTCTGTAGAGG	0.607			NA											9	48					0	0	0.008291	0	0
SEZ6L	23544	broad.mit.edu	37	22	26771546	26771546	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr22:26771546G>A	uc003acb.2	+	15	2989	c.2833G>A	c.(2833-2835)GAA>AAA	p.E945K	SEZ6L_uc003acc.2_Missense_Mutation_p.E944K|SEZ6L_uc011akc.1_Missense_Mutation_p.E934K|SEZ6L_uc003acd.2_Missense_Mutation_p.E870K|SEZ6L_uc011akd.1_Splice_Site_p.E932_splice|SEZ6L_uc003ace.2_Missense_Mutation_p.E869K|SEZ6L_uc003acf.1_Missense_Mutation_p.E717K|SEZ6L_uc010gvc.1_Missense_Mutation_p.E641K|SEZ6L_uc011ake.1_Intron	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	945	Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						TTCAGTAGCAGAAGCGGCAGC	0.572			NA											6	44					0	0	0.00308	0	0
GCAT	23464	broad.mit.edu	37	22	38211697	38211697	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr22:38211697T>C	uc003atz.2	+	7	862	c.842T>C	c.(841-843)CTG>CCG	p.L281P	GCAT_uc003aua.1_Missense_Mutation_p.L307P	NM_014291	NP_055106	O75600	KBL_HUMAN	glycine C-acetyltransferase precursor	281					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups				0	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CCTGGGCCCCTGGTGTCCCTG	0.652			NA											23	191					0	0	0.002299	0	0
MGAT3	4248	broad.mit.edu	37	22	39883979	39883979	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr22:39883979C>G	uc003axv.3	+	2	866	c.627C>G	c.(625-627)ATC>ATG	p.I209M	MGAT3_uc010gxy.2_Missense_Mutation_p.I209M	NM_002409	NP_002400	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein	209	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity				0	Melanoma(58;0.04)					GCCGCGTCATCAACGCCATCA	0.657			NA											4	20					0	0	0.009096	0	0
BRD1	23774	broad.mit.edu	37	22	50192686	50192686	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr22:50192686G>A	uc003biv.2	-	3	2093	c.1606C>T	c.(1606-1608)CGC>TGC	p.R536C	BRD1_uc011arf.1_Missense_Mutation_p.R131C|BRD1_uc011arg.1_Missense_Mutation_p.R590C|BRD1_uc011arh.1_Missense_Mutation_p.R536C|BRD1_uc003biu.3_Missense_Mutation_p.R536C	NM_014577	NP_055392	O95696	BRD1_HUMAN	bromodomain containing protein 1	536					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			pancreas(1)	1		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		ATCAGCAGGCGAGCGCGCTCC	0.622			NA											5	36					0	0	0.000602	0	0
TYMP	1890	broad.mit.edu	37	22	50967929	50967929	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr22:50967929C>A	uc003bmb.3	-	1	330	c.210G>T	c.(208-210)CAG>CAT	p.Q70H	TYMP_uc003bmc.3_Missense_Mutation_p.Q70H|TYMP_uc003bmd.3_Missense_Mutation_p.Q70H|TYMP_uc010hbd.2_Missense_Mutation_p.Q70H|TYMP_uc003bme.3_Missense_Mutation_p.Q70H|TYMP_uc003bmf.3_Missense_Mutation_p.Q70H|TYMP_uc011arz.1_Missense_Mutation_p.Q70H	NM_001113756	NP_001107228	P19971	TYPH_HUMAN	endothelial cell growth factor 1	70					angiogenesis|cell differentiation|chemotaxis|DNA replication|mitochondrial genome maintenance|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol	growth factor activity|platelet-derived growth factor receptor binding|pyrimidine-nucleoside phosphorylase activity|thymidine phosphorylase activity			ovary(1)	1		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)	Capecitabine(DB01101)|Docetaxel(DB01248)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Sulfasalazine(DB00795)|Tamoxifen(DB00675)	ACGCACCGATCTGTGCGCCCT	0.682			NA											8	100					0.000442599	0.000465572	0.006214	1	0
MLH1	4292	broad.mit.edu	37	3	37059088	37059088	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr3:37059088C>T	uc003cgl.2	+	10	942	c.882C>T	c.(880-882)CTC>CTT	p.L294L	MLH1_uc011aye.1_Silent_p.L53L|MLH1_uc011ayb.1_Silent_p.L53L|MLH1_uc010hge.2_Silent_p.L294L|MLH1_uc003cgn.3_Silent_p.L53L|MLH1_uc011ayc.1_Silent_p.L196L|MLH1_uc011ayd.1_Silent_p.L53L|MLH1_uc003cgo.2_Silent_p.L53L|MLH1_uc010hgg.1_Intron|MLH1_uc010hgh.1_Intron|MLH1_uc010hgi.1_5'UTR|MLH1_uc010hgj.1_Intron|MLH1_uc010hgk.2_Intron|MLH1_uc010hgl.1_5'UTR	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	294			Missing (in HNPCC2).		mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						TCCTGTACCTCAGGTAATGTA	0.418			1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				29	112					0	0	0.008361	0	0
GOLGA4	2803	broad.mit.edu	37	3	37396654	37396655	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr3:37396654_37396655GG>TT	uc003cgv.2	+	22	6943_6944	c.6639_6640GG>TT	c.(6637-6642)TTGGAA>TTTTAA	p.2213_2214LE>F*	GOLGA4_uc003cgw.2_Nonsense_Mutation_p.2228_2229LE>F*|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Nonsense_Mutation_p.2094_2095LE>F*	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	2213_2214	GRIP.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						AGAAAATTTTGGAAAGAGAAGA	0.386			NA											20	106					0	0	0.004672	0	0
EXOG	9941	broad.mit.edu	37	3	38548401	38548401	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr3:38548401C>T	uc003cih.2	+	5	683	c.587C>T	c.(586-588)TCT>TTT	p.S196F	EXOG_uc010hhg.2_RNA|EXOG_uc011ayq.1_Missense_Mutation_p.S146F|EXOG_uc003cij.2_Missense_Mutation_p.S56F|EXOG_uc010hhd.2_Missense_Mutation_p.S56F|EXOG_uc010hhe.2_Missense_Mutation_p.S56F|EXOG_uc003cik.2_Missense_Mutation_p.S56F|EXOG_uc010hhf.2_Missense_Mutation_p.S56F|EXOG_uc003cii.2_Missense_Mutation_p.S56F	NM_005107	NP_005098	Q9Y2C4	EXOG_HUMAN	endo/exonuclease (5'-3'), endonuclease G-like	196						mitochondrial inner membrane	endonuclease activity|metal ion binding|nucleic acid binding				0						TGGGTGGTATCTGGGCCTTTG	0.353			NA											17	77					0	0	0.001882	0	0
KIF15	56992	broad.mit.edu	37	3	44894219	44894219	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr3:44894219G>A	uc003cnx.3	+	35	4308	c.4159G>A	c.(4159-4161)GAA>AAA	p.E1387K	KIF15_uc010hiq.2_Missense_Mutation_p.E1290K|KIF15_uc010hir.2_Missense_Mutation_p.E435K	NM_020242	NP_064627	Q9NS87	KIF15_HUMAN	kinesin family member 15	1387	Potential.				blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		GAAAAGAAGTGAATCTTGAGG	0.353			NA											7	78					0	0	0.001984	0	0
TEX264	51368	broad.mit.edu	37	3	51718530	51718530	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr3:51718530C>T	uc010hls.2	+	4	529	c.360C>T	c.(358-360)TTC>TTT	p.F120F	TEX264_uc003dbk.3_Silent_p.F120F|TEX264_uc010hlt.2_5'UTR|TEX264_uc003dbl.3_Silent_p.F120F|TEX264_uc003dbm.3_Silent_p.F159F	NM_001129884	NP_001123356	Q9Y6I9	TX264_HUMAN	testis expressed 264 precursor	120						extracellular region					0				BRCA - Breast invasive adenocarcinoma(193;8.53e-05)|Kidney(197;0.000594)|KIRC - Kidney renal clear cell carcinoma(197;0.000759)		AATTTGGCTTCAAGGTGTTCT	0.592			NA											10	93					0	0	0.008291	0	0
GPR27	2850	broad.mit.edu	37	3	71804103	71804103	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr3:71804103C>T	uc011bge.1	+	1	903	c.903C>T	c.(901-903)GTC>GTT	p.V301V	EIF4E3_uc003dox.2_5'Flank|EIF4E3_uc011bgd.1_5'Flank|EIF4E3_uc010hoc.2_5'Flank	NM_018971	NP_061844	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	301	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		GGCCCTACGTCGTGGCCAGCT	0.642			NA											9	47					0	0	0.000978	0	0
IMPG2	50939	broad.mit.edu	37	3	100949976	100949976	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr3:100949976C>T	uc003duq.1	-	16	3450	c.3247G>A	c.(3247-3249)GAG>AAG	p.E1083K	IMPG2_uc011bhe.1_Missense_Mutation_p.E946K|IMPG2_uc010hpj.1_Intron	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	1083	Extracellular (Potential).|EGF-like 2.|Hyaluronan-binding motif involved in chondroitin sulfate C-binding (By similarity).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						CACCAGTTCTCACCCACCCGG	0.507			NA											45	227					0	0	0.002852	0	0
DNAJC13	23317	broad.mit.edu	37	3	132196902	132196902	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr3:132196902C>A	uc003eor.2	+	24	2692	c.2627C>A	c.(2626-2628)GCC>GAC	p.A876D		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	876							heat shock protein binding			ovary(1)|breast(1)	2						TGTTTACAAGCCCTTGCTATT	0.333			NA											10	112					0.000673444	0.00070112	0.008291	1	0
TMEM108	66000	broad.mit.edu	37	3	133099400	133099400	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr3:133099400G>A	uc003eph.2	+	4	1119	c.845G>A	c.(844-846)AGA>AAA	p.R282K	TMEM108_uc003epi.2_Missense_Mutation_p.R282K|TMEM108_uc003epj.1_Missense_Mutation_p.R282K|TMEM108_uc003epk.2_Intron|TMEM108_uc003epm.2_Missense_Mutation_p.R233K	NM_023943	NP_076432	Q6UXF1	TM108_HUMAN	transmembrane protein 108 precursor	282	Extracellular (Potential).					integral to membrane				ovary(2)|skin(2)	4						GGCCTTCGCAGAGCAGCCCAG	0.647			NA											13	62					0	0	0.00499	0	0
CPA3	1359	broad.mit.edu	37	3	148596502	148596502	+	Silent	SNP	T	T	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr3:148596502T>C	uc003ewm.2	+	5	493	c.441T>C	c.(439-441)TCT>TCC	p.S147S		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	147					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			AAATTGGATCTACTGTTGAAG	0.299			NA											21	98					0	0	0.002299	0	0
TSC22D2	9819	broad.mit.edu	37	3	150128747	150128747	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr3:150128747A>T	uc003exv.2	+	1	1960	c.1610A>T	c.(1609-1611)CAG>CTG	p.Q537L	TSC22D2_uc003exw.2_RNA|TSC22D2_uc003exx.2_Missense_Mutation_p.Q537L	NM_014779	NP_055594	O75157	T22D2_HUMAN	TSC22 domain family, member 2	537							sequence-specific DNA binding transcription factor activity			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CCTCTGGCCCAGTCGCAACAG	0.602			NA											14	77					0	0	0.00499	0	0
BCHE	590	broad.mit.edu	37	3	165548362	165548362	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr3:165548362G>A	uc003fem.3	-	2	620	c.460C>T	c.(460-462)CAT>TAT	p.H154Y	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	154					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	TCATAAACATGTAAAGATGAT	0.383			NA											18	79					0	0	0.008871	0	0
ZBBX	79740	broad.mit.edu	37	3	166958699	166958699	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr3:166958699C>T	uc003fep.2	-	21	2608	c.2285G>A	c.(2284-2286)GGA>GAA	p.G762E	ZBBX_uc011bpc.1_Missense_Mutation_p.G801E|ZBBX_uc003feq.2_Missense_Mutation_p.G733E	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	762						intracellular	zinc ion binding			ovary(2)	2						GGTATCTCTTCCAGAACAGCT	0.378			NA											18	79					0	0	0.00499	0	0
FXR1	8087	broad.mit.edu	37	3	180671582	180671582	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr3:180671582C>T	uc003fkq.2	+	9	856	c.834C>T	c.(832-834)TTC>TTT	p.F278F	FXR1_uc003fkp.2_Silent_p.F193F|FXR1_uc003fkr.2_Silent_p.F278F|FXR1_uc011bqj.1_Silent_p.F192F|FXR1_uc003fks.2_Silent_p.F192F|FXR1_uc011bqk.1_Silent_p.F229F|FXR1_uc011bql.1_Silent_p.F265F	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	278					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			CTAGAGGTTTCTTGGAATTTG	0.338			NA											47	152					0	0	0.00361	0	0
ALG3	10195	broad.mit.edu	37	3	183960694	183960694	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr3:183960694C>T	uc003fne.2	-	8	1092	c.1061G>A	c.(1060-1062)CGC>CAC	p.R354H	ALG3_uc011brc.1_Missense_Mutation_p.R319H|ALG3_uc011brd.1_Missense_Mutation_p.R298H|ALG3_uc011bre.1_Missense_Mutation_p.R306H	NM_005787	NP_005778	Q92685	ALG3_HUMAN	alpha-1,3-mannosyltransferase ALG3 isoform a	354					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity				0	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GTGGAGGGAGCGGCTGAAGCA	0.572			NA											6	39					0	0	0.00308	0	0
MAP3K13	9175	broad.mit.edu	37	3	185169074	185169074	+	Splice_Site	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr3:185169074G>A	uc010hyf.2	+	8	1436	c.1170_splice	c.e8-1	p.W390_splice	MAP3K13_uc011brt.1_Splice_Site_p.W183_splice|MAP3K13_uc003fph.3_Splice_Site_p.W158_splice|MAP3K13_uc011bru.1_Splice_Site_p.W246_splice|MAP3K13_uc003fpi.2_Splice_Site_p.W390_splice|MAP3K13_uc010hyg.2_Splice_Site_p.W80_splice	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase						activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TTCACTTTTAGGCAGAGTAAA	0.383			NA											30	81					0	0	0.007291	0	0
DNAJB11	51726	broad.mit.edu	37	3	186301672	186301672	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr3:186301672G>C	uc003fqi.2	+	8	979	c.759G>C	c.(757-759)AGG>AGC	p.R253S		NM_016306	NP_057390	Q9UBS4	DJB11_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 11	253					protein folding	endoplasmic reticulum lumen	heat shock protein binding			ovary(1)|lung(1)	2	all_cancers(143;2.84e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.44e-20)	GBM - Glioblastoma multiforme(93;0.0476)		TATTTGAAAGGAGAGGAGATG	0.338			NA											4	112					0	0	0.009096	0	0
PIGX	54965	broad.mit.edu	37	3	196460684	196460684	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr3:196460684C>G	uc010iaj.2	+	7	900	c.619C>G	c.(619-621)CTA>GTA	p.L207V	PIGX_uc003fwx.3_Missense_Mutation_p.L189V|PIGX_uc011btx.1_RNA	NM_017861	NP_060331	Q8TBF5	PIGX_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	230	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane					0	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;1.08e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00322)		ACATACCTCTCTAGTATGTTC	0.378			NA											37	96					0	0	0.004289	0	0
EXOC1	55763	broad.mit.edu	37	4	56737273	56737273	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr4:56737273A>G	uc003hbe.1	+	7	996	c.838A>G	c.(838-840)ATG>GTG	p.M280V	EXOC1_uc003hbf.1_Missense_Mutation_p.M280V|EXOC1_uc003hbg.1_Missense_Mutation_p.M280V	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	exocyst complex component 1 isoform 1	280					exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)					CTAGAACCACATGGACTTGGC	0.433			NA											6	107					0	0	0.001168	0	0
SULT1B1	27284	broad.mit.edu	37	4	70596267	70596267	+	Silent	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr4:70596267G>A	uc003hen.2	-	7	1028	c.730C>T	c.(730-732)CTA>TTA	p.L244L		NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member	244					3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						GTAGTTGGTAGATGTGTATAA	0.358			NA											15	128					0	0	0.004007	0	0
GC	2638	broad.mit.edu	37	4	72634141	72634141	+	Silent	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr4:72634141G>T	uc003hge.2	-	3	291	c.138C>A	c.(136-138)GTC>GTA	p.V46V	GC_uc003hgd.2_5'UTR|GC_uc010iie.2_Silent_p.V46V|GC_uc010iif.2_Silent_p.V65V	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	46	Albumin 1.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	TACTGTACAGGACTAGTGACC	0.353			NA											9	53					3.86212e-05	4.14871e-05	0.008291	1	0
BMP2K	55589	broad.mit.edu	37	4	79793823	79793823	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr4:79793823C>T	uc003hlk.2	+	13	1830	c.1664C>T	c.(1663-1665)CCG>CTG	p.P555L	BMP2K_uc003hlj.2_Missense_Mutation_p.P555L|BMP2K_uc003hll.2_Missense_Mutation_p.P19L	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	555	Gln/His-rich.					nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						CAACATCAGCCGTCTCAACAA	0.443			NA											8	61					0	0	0.00308	0	0
DKK2	27123	broad.mit.edu	37	4	107845160	107845160	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr4:107845160T>C	uc003hyi.2	-	4	1436	c.731A>G	c.(730-732)GAT>GGT	p.D244G	DKK2_uc003hyj.1_3'UTR	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	244	DKK-type Cys-2.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		GTAGGTGGCATCTTTCCATAC	0.458			NA											31	253					0	0	0.002096	0	0
PAPSS1	9061	broad.mit.edu	37	4	108552995	108552995	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr4:108552995G>A	uc003hyk.2	-	11	1612	c.1528C>T	c.(1528-1530)CGG>TGG	p.R510W		NM_005443	NP_005434	O43252	PAPS1_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase	510	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|sulfate adenylyltransferase (ATP) activity			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.49e-05)		GCAACCATCCGTGCTCTGCAA	0.418			NA											4	57					0	0	0.000602	0	0
KLKB1	3818	broad.mit.edu	37	4	187149394	187149394	+	Silent	SNP	T	T	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr4:187149394T>A	uc003iyy.2	+	2	116	c.45T>A	c.(43-45)GCT>GCA	p.A15A	KLKB1_uc011clc.1_5'UTR|KLKB1_uc011cld.1_Intron	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	15					blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		CCTTGTTTGCTACAGTTTCCT	0.353			NA											7	30					0	0	0.00308	0	0
SLC12A7	10723	broad.mit.edu	37	5	1089245	1089245	+	Splice_Site	SNP	T	T	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:1089245T>A	uc003jbu.2	-	4	409	c.343_splice	c.e4-1	p.A115_splice		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride						potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	GCGCGGAGCCTGCGACAGAGC	0.682			NA											23	251					0	0	0.001882	0	0
HCN1	348980	broad.mit.edu	37	5	45267266	45267266	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:45267266T>A	uc003jok.2	-	7	1733	c.1708A>T	c.(1708-1710)AAC>TAC	p.N570Y		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	570	cAMP.|Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						AGGACCTCGTTGAAATTGTCC	0.433			NA											9	198					0	0	0.006214	0	0
MAP3K1	4214	broad.mit.edu	37	5	56183268	56183268	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:56183268C>G	uc003jqw.3	+	18	4679	c.4178C>G	c.(4177-4179)GCC>GGC	p.A1393G		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	1393	Protein kinase.				cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		GGAGCTGCAGCCAGGTTGGCA	0.443			NA											11	157					0	0	0.001368	0	0
POLK	51426	broad.mit.edu	37	5	74880722	74880722	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:74880722C>T	uc003kdw.2	+	9	1293	c.1197C>T	c.(1195-1197)TCC>TCT	p.S399S	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc003keb.2_Silent_p.S399S|POLK_uc010izq.2_Intron|POLK_uc003kec.2_Silent_p.S309S|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Silent_p.S309S|POLK_uc003kee.2_Silent_p.S399S|POLK_uc003kef.2_Silent_p.S309S	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	399					DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		TTCATATCTCCTTGGGTCTAG	0.388			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					8	208					0	0	0.006214	0	0
CETN3	1070	broad.mit.edu	37	5	89695226	89695226	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:89695226C>A	uc003kjo.2	-	4	534	c.409G>T	c.(409-411)GAA>TAA	p.E137*		NM_004365	NP_004356	O15182	CETN3_HUMAN	centrin 3	137	EF-hand 4.				cell division|centrosome cycle|mitosis	centriole	calcium ion binding				0		all_cancers(142;7.93e-09)|all_epithelial(76;2.13e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.42e-32)|Epithelial(54;1.45e-26)|all cancers(79;2.87e-23)		CGAAGTTCTTCATCACTCATG	0.358			NA											19	98					1.56452e-12	1.80842e-12	0.007413	1	0
MCTP1	79772	broad.mit.edu	37	5	94248517	94248517	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:94248517C>G	uc003kkx.2	-	9	1515	c.1515G>C	c.(1513-1515)AAG>AAC	p.K505N	MCTP1_uc003kkv.2_Missense_Mutation_p.K284N|MCTP1_uc003kkw.2_Missense_Mutation_p.K238N|MCTP1_uc003kkz.2_Missense_Mutation_p.K166N|MCTP1_uc003kku.2_Missense_Mutation_p.K21N	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	505	C2 2.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TTACCTTGCTCTTGTACTTCT	0.458			NA											25	100					0	0	0.005443	0	0
LNPEP	4012	broad.mit.edu	37	5	96350700	96350700	+	Silent	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:96350700G>A	uc003kmv.1	+	13	2791	c.2277G>A	c.(2275-2277)GAG>GAA	p.E759E	LNPEP_uc003kmw.1_Silent_p.E745E	NM_005575	NP_005566	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase isoform 1	759	Extracellular (Potential).				cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		TTGGAAATGAGAACCATACTG	0.433			NA											34	172					0	0	0.003755	0	0
UQCRQ	27089	broad.mit.edu	37	5	132203218	132203218	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:132203218G>C	uc003kya.1	+	3	267	c.193G>C	c.(193-195)GAA>CAA	p.E65Q	GDF9_uc003kxz.1_5'Flank|GDF9_uc011cxj.1_5'Flank	NM_014402	NP_055217	O14949	QCR8_HUMAN	ubiquinol-cytochrome c reductase, complex III	65					respiratory electron transport chain	mitochondrial inner membrane|respiratory chain	ubiquinol-cytochrome-c reductase activity				0		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATGGGGGACTGAAGAGTTCGA	0.388			NA											10	64					0	0	0.008291	0	0
KLHL3	26249	broad.mit.edu	37	5	136963999	136963999	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:136963999G>T	uc010jek.2	-	13	2022	c.1578C>A	c.(1576-1578)TGC>TGA	p.C526*	KLHL3_uc011cyc.1_Nonsense_Mutation_p.C261*|KLHL3_uc003lbr.3_Nonsense_Mutation_p.C444*|KLHL3_uc011cyd.1_RNA	NM_017415	NP_059111	Q9UH77	KLHL3_HUMAN	kelch-like 3	526	Kelch 5.					cytoplasm|cytoskeleton	actin binding|structural molecule activity				0		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		CGTTGCGCCGGCACATGTTCA	0.537			NA											61	251					1.08141e-31	1.34733e-31	0.00361	1	0
PCDHA8	56140	broad.mit.edu	37	5	140222842	140222842	+	Missense_Mutation	SNP	C	C	T	rs146582216		TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:140222842C>T	uc003lhs.2	+	1	1936	c.1936C>T	c.(1936-1938)CGT>TGT	p.R646C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.R646C	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	646	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCGCGCCACCGTCTGCTGGT	0.662			NA											18	214					0	0	0.006122	0	0
JAKMIP2	9832	broad.mit.edu	37	5	146997641	146997641	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:146997641G>C	uc003loq.1	-	19	2561	c.2179C>G	c.(2179-2181)CTA>GTA	p.L727V	JAKMIP2_uc011dbx.1_Missense_Mutation_p.L685V|JAKMIP2_uc003lor.1_Missense_Mutation_p.L706V|uc003lop.1_Intron|JAKMIP2_uc010jgo.1_Missense_Mutation_p.L727V	NM_014790	NP_055605	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein	727	Potential.					Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTTGCTGTAGAGCATTGTAC	0.408			NA											21	136					0	0	0.002299	0	0
PDGFRB	5159	broad.mit.edu	37	5	149514487	149514487	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:149514487C>G	uc003lro.2	-	4	926	c.457G>C	c.(457-459)GAC>CAC	p.D153H	PDGFRB_uc010jhd.2_5'UTR|PDGFRB_uc011dcg.1_Missense_Mutation_p.D153H	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	153	Extracellular (Potential).|Ig-like C2-type 2.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	AGCTGTGGGTCTGTTACTCGG	0.522			NA	T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								42	208					0	0	0.003214	0	0
CYFIP2	26999	broad.mit.edu	37	5	156755057	156755057	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:156755057G>T	uc003lwq.2	+	21	2294	c.2156G>T	c.(2155-2157)AGT>ATT	p.S719I	CYFIP2_uc011ddn.1_Missense_Mutation_p.S693I|CYFIP2_uc011ddo.1_Missense_Mutation_p.S523I|CYFIP2_uc003lwr.2_Missense_Mutation_p.S719I|CYFIP2_uc003lws.2_Missense_Mutation_p.S719I|CYFIP2_uc003lwt.2_Missense_Mutation_p.S622I|CYFIP2_uc011ddp.1_Missense_Mutation_p.S453I	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	744					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ATGGCTGGCAGGTAGGAAAGC	0.468			NA											13	83					7.93312e-07	8.70639e-07	0.00245	1	0
NIPAL4	348938	broad.mit.edu	37	5	156899773	156899773	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:156899773C>G	uc003lwx.3	+	6	1322	c.1206C>G	c.(1204-1206)TTC>TTG	p.F402L	ADAM19_uc003lww.1_Intron|NIPAL4_uc011ddq.1_Missense_Mutation_p.F383L	NM_001099287	NP_001092757	Q0D2K0	NIPA4_HUMAN	ichthyin protein	402	Helical; (Potential).					integral to membrane	receptor activity				0						TGGGCGTGTTCATGCTGCATG	0.547			NA											15	95					0	0	0.004007	0	0
NOP16	51491	broad.mit.edu	37	5	175812222	175812222	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:175812222C>T	uc011dfl.1	-	4	393	c.393G>A	c.(391-393)AAG>AAA	p.K131K	NOP16_uc003med.2_Silent_p.K131K|NOP16_uc003mee.2_Silent_p.K131K	NM_016391	NP_057475	Q9Y3C1	NOP16_HUMAN	NOP16 nucleolar protein homolog	131						nucleolus				ovary(1)|central_nervous_system(1)	2						AGCCGCTCACCTTATAGTCCT	0.562			NA											25	149					0	0	0.004656	0	0
GRK6	2870	broad.mit.edu	37	5	176859748	176859748	+	Silent	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:176859748G>C	uc011dfz.1	+	5	541	c.381G>C	c.(379-381)ACG>ACC	p.T127T	GRK6_uc003mgp.2_Silent_p.T127T|GRK6_uc003mgq.2_Silent_p.T127T|GRK6_uc003mgs.1_Silent_p.T97T	NM_002082	NP_002073	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6 isoform B	127	N-terminal.|RGS.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)|stomach(1)|breast(1)	3	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGCTGGTGACGAACTGCACCC	0.632			NA											4	42					0	0	0.001984	0	0
GRK6	2870	broad.mit.edu	37	5	176867754	176867754	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:176867754C>T	uc011dfz.1	+	14	1618	c.1458C>T	c.(1456-1458)GTC>GTT	p.V486V	GRK6_uc003mgq.2_Silent_p.V486V|GRK6_uc003mgs.1_Silent_p.V456V|uc003mgt.2_Intron	NM_002082	NP_002073	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6 isoform B	486	AGC-kinase C-terminal.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)|stomach(1)|breast(1)	3	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCTCTACGGTCAAGGGCGTGG	0.582			NA											31	112					0	0	0.008361	0	0
RUFY1	80230	broad.mit.edu	37	5	178996340	178996340	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:178996340G>A	uc003mka.1	+	5	742	c.742G>A	c.(742-744)GAA>AAA	p.E248K	RUFY1_uc003mkb.1_Missense_Mutation_p.E140K|RUFY1_uc003mkc.1_Missense_Mutation_p.E140K	NM_025158	NP_079434	Q96T51	RUFY1_HUMAN	RUN and FYVE domain-containing 1 isoform a	248	RUN.				endocytosis|protein transport	early endosome membrane	lipid binding|zinc ion binding			ovary(4)|breast(1)	5	all_cancers(89;0.00018)|all_epithelial(37;8.37e-05)|Renal(175;0.000159)|Lung NSC(126;0.00108)|all_lung(126;0.00195)	all_cancers(40;0.0322)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GATGGAGGAAGAAGGGATGGT	0.478			NA								HNSCC(44;0.11)			17	273					0	0	0.006122	0	0
TRIM7	81786	broad.mit.edu	37	5	180622504	180622504	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr5:180622504C>G	uc003mmz.1	-	7	1265	c.1198G>C	c.(1198-1200)GAG>CAG	p.E400Q	TRIM7_uc003mmv.1_Missense_Mutation_p.E218Q|TRIM7_uc003mmw.1_Missense_Mutation_p.E192Q|TRIM7_uc003mmx.1_Missense_Mutation_p.E192Q|TRIM7_uc003mmy.1_Missense_Mutation_p.E192Q	NM_203293	NP_976038	Q9C029	TRIM7_HUMAN	tripartite motif-containing 7 isoform 1	400	B30.2/SPRY.					cytoplasm|nucleus	zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;6.03e-06)|all_epithelial(37;7.1e-07)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000172)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;2e-06)|Epithelial(171;1.35e-05)|OV - Ovarian serous cystadenocarcinoma(192;0.000128)|Kidney(146;0.0674)|GBM - Glioblastoma multiforme(465;0.0802)		ACCTCCACCTCCCAGTGATGC	0.716	Esophageal Squamous(128;2258 2308 35507 48647)		NA											12	37					0	0	0.003163	0	0
DNAH8	1769	broad.mit.edu	37	6	38790666	38790666	+	Silent	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr6:38790666G>T	uc003ooe.1	+	25	3525	c.2925G>T	c.(2923-2925)GGG>GGT	p.G975G		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TTTACCCGGGGGTAGCGGAGC	0.413			NA											10	58					0.00621372	0.006447	0.006214	1	0
TBCC	6903	broad.mit.edu	37	6	42713509	42713509	+	Silent	SNP	T	T	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr6:42713509T>G	uc003osl.2	-	1	376	c.303A>C	c.(301-303)TCA>TCC	p.S101S		NM_003192	NP_003183	Q15814	TBCC_HUMAN	beta-tubulin cofactor C	101					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|photoreceptor connecting cilium	chaperone binding|GTPase activity				0	Colorectal(47;0.196)		all cancers(41;0.00122)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.125)			GGAAAAAAACTGAGTCGTTGA	0.682			NA											5	107					0	0	0.001984	0	0
SLC35B2	347734	broad.mit.edu	37	6	44222521	44222521	+	Silent	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr6:44222521G>C	uc003oxd.2	-	4	1357	c.1221C>G	c.(1219-1221)CTC>CTG	p.L407L	SLC35B2_uc011dvt.1_Silent_p.L310L|SLC35B2_uc011dvu.1_Silent_p.L274L	NM_178148	NP_835361	Q8TB61	S35B2_HUMAN	solute carrier family 35, member B2	407	Helical; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CGTAGACTCTGAGCAGGAGGG	0.602			NA											21	142					0	0	0.001882	0	0
MUT	4594	broad.mit.edu	37	6	49425625	49425625	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr6:49425625G>C	uc003ozg.3	-	3	787	c.532C>G	c.(532-534)CCT>GCT	p.P178A		NM_000255	NP_000246	P22033	MUTA_HUMAN	methylmalonyl Coenzyme A mutase precursor	178					fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity				0	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTTTCTAAAGGAATTCCATCA	0.383			NA											13	101					0	0	0.001855	0	0
PKHD1	5314	broad.mit.edu	37	6	51889442	51889442	+	Silent	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr6:51889442G>A	uc003pah.1	-	32	5442	c.5166C>T	c.(5164-5166)ATC>ATT	p.I1722I	PKHD1_uc003pai.2_Silent_p.I1722I	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1722	IPT/TIG 12; atypical.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CCCACCCTCTGATGCAGTCAT	0.532			NA											14	153					0	0	0.00245	0	0
ELOVL5	60481	broad.mit.edu	37	6	53156718	53156718	+	Silent	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr6:53156718G>A	uc003pbq.1	-	3	550	c.102C>T	c.(100-102)CCC>CCT	p.P34P	ELOVL5_uc003pbr.1_Silent_p.P34P|ELOVL5_uc011dwx.1_Silent_p.P34P|ELOVL5_uc003pbs.1_Silent_p.P34P	NM_021814	NP_068586	Q9NYP7	ELOV5_HUMAN	elongation of very long chain fatty acids-like	34	Helical; (Potential).				fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0	Lung NSC(77;0.116)					AGATAAATGTGGGTATATAAT	0.313			NA											11	123					0	0	0.001855	0	0
TAAR9	134860	broad.mit.edu	37	6	132859813	132859813	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr6:132859813G>T	uc011eci.1	+	2	387	c.385G>T	c.(385-387)GAT>TAT	p.D129Y		NM_175057	NP_778227	Q96RI9	TAAR9_HUMAN	trace amine associated receptor 9	129	Cytoplasmic (Potential).					plasma membrane	G-protein coupled receptor activity				0	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.0042)|GBM - Glioblastoma multiforme(226;0.00816)		TATCTCTGTTGATAGATACAT	0.383	Colon(10;433 445 15992 45047 47213)		NA											8	91					3.09899e-07	3.42579e-07	0.004482	1	0
UTRN	7402	broad.mit.edu	37	6	145103245	145103245	+	Silent	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr6:145103245C>G	uc003qkt.2	+	60	8912	c.8820C>G	c.(8818-8820)CTC>CTG	p.L2940L		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2940	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		ATTGGTTGCTCAATGTCTATG	0.323			NA											9	54					0	0	0.008291	0	0
ULBP3	79465	broad.mit.edu	37	6	150385794	150385794	+	Silent	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr6:150385794G>C	uc003qns.3	-	4	684	c.684C>G	c.(682-684)CTC>CTG	p.L228L	ULBP3_uc011eej.1_Silent_p.L103L	NM_024518	NP_078794	Q9BZM4	N2DL3_HUMAN	UL16 binding protein 3 precursor	228					antigen processing and presentation|immune response|natural killer cell activation	anchored to membrane|MHC class I protein complex	MHC class I receptor activity				0		Ovarian(120;0.12)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.45e-12)		TCCAGGGACTGAGGGTGGTGG	0.527			NA											15	126					0	0	0.00499	0	0
TRA2A	29896	broad.mit.edu	37	7	23571409	23571409	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr7:23571409C>G	uc003swi.2	-	1	249	c.35G>C	c.(34-36)AGA>ACA	p.R12T	TRA2A_uc011jzb.1_RNA|TRA2A_uc011jzc.1_5'UTR|TRA2A_uc011jzd.1_5'UTR|TRA2A_uc010kuo.1_RNA	NM_013293	NP_037425	Q13595	TRA2A_HUMAN	transformer-2 alpha	12					nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|RNA binding			ovary(1)	1						TGTACTCACTCTGCCCTCGAA	0.612	Pancreas(121;2137 2973 46590)		NA											12	100					0	0	0.003163	0	0
DFNA5	1687	broad.mit.edu	37	7	24756942	24756942	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr7:24756942C>A	uc010kus.1	-	5	716	c.628G>T	c.(628-630)GAG>TAG	p.E210*	DFNA5_uc003swz.2_Nonsense_Mutation_p.E46*|DFNA5_uc003sxa.1_Nonsense_Mutation_p.E210*|DFNA5_uc010kut.1_Nonsense_Mutation_p.E46*|DFNA5_uc003sxb.2_Nonsense_Mutation_p.E210*	NM_001127453	NP_001120925	O60443	DFNA5_HUMAN	deafness, autosomal dominant 5 protein isoform	210					sensory perception of sound					ovary(1)	1						GCTGGGATCTCCAGCACCACG	0.587	GBM(78;184 1250 20134 20900 23600)		NA											17	91					0.000422831	0.000447877	0.004007	1	0
GARS	2617	broad.mit.edu	37	7	30661020	30661020	+	Silent	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr7:30661020G>A	uc003tbm.2	+	11	1728	c.1371G>A	c.(1369-1371)GAG>GAA	p.E457E		NM_002047	NP_002038	P41250	SYG_HUMAN	glycyl-tRNA synthetase	457	ATP.				cell death|diadenosine tetraphosphate biosynthetic process|glycyl-tRNA aminoacylation	cytosol|mitochondrial matrix|soluble fraction	ATP binding|glycine-tRNA ligase activity|protein dimerization activity			ovary(1)	1					Glycine(DB00145)	GTTGGATTGAGATTGTTGGAT	0.368			NA											48	229					0	0	0.003214	0	0
PURB	5814	broad.mit.edu	37	7	44924761	44924761	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr7:44924761C>T	uc003tme.2	-	1	200	c.187G>A	c.(187-189)GAG>AAG	p.E63K		NM_033224	NP_150093	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	63	By similarity.				regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding				0						GCGCCCACCTCGGCGATCTTG	0.632			NA											5	36					0	0	0.001168	0	0
ABCA13	154664	broad.mit.edu	37	7	48349715	48349715	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr7:48349715G>C	uc003toq.2	+	24	9518	c.9493G>C	c.(9493-9495)GAT>CAT	p.D3165H	ABCA13_uc010kys.1_Missense_Mutation_p.D239H|ABCA13_uc003tos.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3165					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TCGAAACTTGGATGTGCGAGC	0.502			NA											42	367					0	0	0.003214	0	0
ABCA13	154664	broad.mit.edu	37	7	48563896	48563896	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr7:48563896G>A	uc003toq.2	+	54	14129	c.14104G>A	c.(14104-14106)GAA>AAA	p.E4702K	ABCA13_uc010kys.1_Missense_Mutation_p.E1777K|ABCA13_uc010kyt.1_RNA|ABCA13_uc010kyu.1_Missense_Mutation_p.E432K	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4702					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TACAGATGTTGAAAAAGAGGA	0.383			NA											7	27					0	0	0.004482	0	0
COBL	23242	broad.mit.edu	37	7	51261203	51261203	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr7:51261203G>A	uc003tpr.3	-	3	514	c.329C>T	c.(328-330)TCA>TTA	p.S110L	COBL_uc003tps.2_Missense_Mutation_p.S110L|COBL_uc011kcl.1_Missense_Mutation_p.S110L|COBL_uc010kzc.2_Missense_Mutation_p.S110L|COBL_uc003tpt.2_Missense_Mutation_p.S110L|COBL_uc003tpp.3_5'Flank|COBL_uc003tpq.3_Missense_Mutation_p.S26L	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	110										skin(3)|ovary(2)	5	Glioma(55;0.08)					TTGGGTTTCTGAAGACCGAAT	0.423	NSCLC(189;2119 2138 12223 30818 34679)		NA											22	86					0	0	0.002299	0	0
ABHD11	83451	broad.mit.edu	37	7	73150991	73150991	+	Silent	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr7:73150991G>A	uc003tzb.2	-	6	903	c.846C>T	c.(844-846)CTC>CTT	p.L282L	RFC2_uc011kfa.1_Intron|ABHD11_uc011kfb.1_Silent_p.L225L|ABHD11_uc003tzc.2_Silent_p.L275L|ABHD11_uc003tza.2_Silent_p.L169L	NM_148912	NP_683710	Q8NFV4	ABHDB_HUMAN	abhydrolase domain containing 11 isoform 1	282							hydrolase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				CCCGAGGGAAGAGCCGCATAA	0.607			NA											19	103					0	0	0.001882	0	0
GTF2I	2969	broad.mit.edu	37	7	74114631	74114631	+	Missense_Mutation	SNP	G	G	A	rs145729076		TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr7:74114631G>A	uc003uau.2	+	5	798	c.428G>A	c.(427-429)CGA>CAA	p.R143Q	GTF2I_uc003uat.2_Missense_Mutation_p.R143Q|GTF2I_uc003uav.2_Missense_Mutation_p.R143Q|GTF2I_uc003uaw.2_Missense_Mutation_p.R143Q|GTF2I_uc003uay.2_Missense_Mutation_p.R143Q|GTF2I_uc003uax.2_Missense_Mutation_p.R143Q|uc003uaz.2_RNA	NM_032999	NP_127492	P78347	GTF2I_HUMAN	general transcription factor IIi isoform 1	143	GTF2I-like 1.				negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						AAGATGCTGCGAGACCAGTCG	0.478			NA											15	298					0	0	0.006122	0	0
CCDC146	57639	broad.mit.edu	37	7	76889471	76889471	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr7:76889471G>C	uc003uga.2	+	8	1031	c.904G>C	c.(904-906)GAA>CAA	p.E302Q	CCDC146_uc010ldp.2_Missense_Mutation_p.E48Q	NM_020879	NP_065930	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	302	Potential.									ovary(1)|central_nervous_system(1)	2		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				AGCCTTACTTGAAATCAAAGA	0.348			NA											30	70					0	0	0.003271	0	0
PCLO	27445	broad.mit.edu	37	7	82763878	82763878	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr7:82763878C>T	uc003uhx.2	-	3	3277	c.2988G>A	c.(2986-2988)GTG>GTA	p.V996V	PCLO_uc003uhv.2_Silent_p.V996V	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	942	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTTCCTTTTTCACAGGTATAC	0.468			NA											21	52					0	0	0.001882	0	0
ASNS	440	broad.mit.edu	37	7	97486051	97486051	+	Silent	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr7:97486051G>A	uc003uot.3	-	8	1487	c.981C>T	c.(979-981)GTC>GTT	p.V327V	ASNS_uc011kin.1_Silent_p.V244V|ASNS_uc003uou.3_Silent_p.V327V|ASNS_uc003uov.3_Silent_p.V327V|ASNS_uc011kio.1_Silent_p.V306V|ASNS_uc003uow.3_Silent_p.V306V|ASNS_uc003uox.3_Silent_p.V244V	NM_133436	NP_597680	P08243	ASNS_HUMAN	asparagine synthetase	327	Asparagine synthetase.				cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AGGAAAATATGACTTCATCCA	0.318	Melanoma(70;6 1280 3108 3799 51123)|GBM(6;275 291 425 9929 27738)		NA											18	158					0	0	0.007413	0	0
TRRAP	8295	broad.mit.edu	37	7	98497313	98497313	+	Silent	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr7:98497313G>A	uc003upp.2	+	10	932	c.723G>A	c.(721-723)CTG>CTA	p.L241L	TRRAP_uc011kis.1_Silent_p.L241L|TRRAP_uc003upr.2_5'Flank	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	241					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCTACAAACTGAACATCCACA	0.443			NA											51	116					0	0	0.00361	0	0
STAG3	10734	broad.mit.edu	37	7	99786150	99786150	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr7:99786150G>A	uc003utx.1	+	6	663	c.508G>A	c.(508-510)GAG>AAG	p.E170K	STAG3_uc010lgs.1_5'UTR|STAG3_uc011kjk.1_Intron	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	170					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCAGTTTAATGAGGTGGAAGA	0.413			NA											74	409					0	0	0.00361	0	0
SLC26A3	1811	broad.mit.edu	37	7	107416977	107416977	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr7:107416977C>T	uc003ver.2	-	15	1808	c.1597G>A	c.(1597-1599)GAA>AAA	p.E533K	SLC26A3_uc003ves.2_Missense_Mutation_p.E498K	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	533	STAS.				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						TTCACTCCTTCTGGCTCATAC	0.378			NA											11	124					0	0	0.000978	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121680889	121680889	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr7:121680889C>G	uc003vjy.2	+	21	6052	c.5657C>G	c.(5656-5658)CCC>CGC	p.P1886R	PTPRZ1_uc003vjz.2_Missense_Mutation_p.P1019R|PTPRZ1_uc011knt.1_Missense_Mutation_p.P476R	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1886	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						AAAGGAAGACCCAGTGGACGT	0.393			NA											20	125					0	0	0.010504	0	0
POT1	25913	broad.mit.edu	37	7	124503575	124503575	+	Silent	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr7:124503575G>A	uc003vlm.2	-	8	976	c.375C>T	c.(373-375)TTC>TTT	p.F125F	POT1_uc011koe.1_RNA|POT1_uc003vlk.2_RNA|POT1_uc003vll.2_RNA|POT1_uc003vlo.2_5'UTR|POT1_uc003vln.2_RNA	NM_015450	NP_056265	Q9NUX5	POTE1_HUMAN	protection of telomeres 1 isoform 1	125					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			central_nervous_system(1)	1						CCTCAGTAGTGAAGTTAAAAT	0.443	Esophageal Squamous(149;1032 1141 16047 36610 40540 42429 44687 51642)		NA											77	180					0	0	0.00361	0	0
BRAF	673	broad.mit.edu	37	7	140453193	140453193	+	Missense_Mutation	SNP	T	T	C	rs121913370		TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr7:140453193T>C	uc003vwc.3	-	15	1803	c.1742A>G	c.(1741-1743)AAT>AGT	p.N581S		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	581	Protein kinase.		N -> D (in CFC syndrome).|N -> S (in a colorectal adenocarcinoma sample; somatic mutation).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.N581S(7)|p.N581Y(1)|p.N581I(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	AAGAAATATATCTGAGGTGTA	0.358	Colon(40;35 892 2973 5743 27438)		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				44	77					0	0	0.00361	0	0
CSMD1	64478	broad.mit.edu	37	8	2876054	2876054	+	Silent	SNP	A	A	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr8:2876054A>G	uc011kwk.1	-	52	8367	c.7977T>C	c.(7975-7977)CAT>CAC	p.H2659H	CSMD1_uc011kwj.1_Silent_p.H1988H|CSMD1_uc010lrg.2_Intron	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2659	Extracellular (Potential).|Sushi 17.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ACTCTCTGACATGAGACCCCA	0.483			NA											40	264					0	0	0.007835	0	0
PSD3	23362	broad.mit.edu	37	8	18430067	18430067	+	Silent	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr8:18430067G>A	uc003wza.2	-	14	2858	c.2755C>T	c.(2755-2757)CTG>TTG	p.L919L	PSD3_uc003wyx.3_Silent_p.L248L|PSD3_uc003wyy.2_Silent_p.L385L|PSD3_uc003wyz.2_Silent_p.L220L	NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	920					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		GTGGCAGGCAGAAGTGGGCGG	0.408			NA											21	87					0	0	0.00333	0	0
PPP2R2A	5520	broad.mit.edu	37	8	26223870	26223870	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr8:26223870G>A	uc003xeu.2	+	9	1314	c.1012G>A	c.(1012-1014)GAA>AAA	p.E338K	PPP2R2A_uc003xek.2_Missense_Mutation_p.E339K|PPP2R2A_uc011laf.1_Missense_Mutation_p.E348K	NM_002717	NP_002708	P63151	2ABA_HUMAN	alpha isoform of regulatory subunit B55, protein	338	WD 6.				protein dephosphorylation|signal transduction	protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity			ovary(1)|kidney(1)	2		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.000754)|Epithelial(17;3.02e-15)|all cancers(2;1.52e-13)|OV - Ovarian serous cystadenocarcinoma(2;1.89e-10)|Colorectal(74;0.155)		TTCACTGTATGAAAATGACTG	0.229			NA											29	151					0	0	0.002445	0	0
LYN	4067	broad.mit.edu	37	8	56866476	56866476	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr8:56866476G>C	uc003xsk.3	+	8	1005	c.723G>C	c.(721-723)GAG>GAC	p.E241D	LYN_uc003xsl.3_Missense_Mutation_p.E220D	NM_002350	NP_002341	P07948	LYN_HUMAN	Yamaguchi sarcoma viral (v-yes-1) oncogene	241					erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			ATGCCTGGGAGATCCCCCGGG	0.527			NA											14	136					0	0	0.00245	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70617351	70617351	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr8:70617351C>A	uc003xyl.2	-	6	2244	c.1537G>T	c.(1537-1539)GTG>TTG	p.V513L	SLCO5A1_uc010lzb.2_Missense_Mutation_p.V458L|SLCO5A1_uc011lfa.1_Intron|SLCO5A1_uc003xyk.2_Missense_Mutation_p.V513L|SLCO5A1_uc010lzc.2_Missense_Mutation_p.V458L	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	513	Helical; Name=9; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			AGTAAAGACACACCACTGCAG	0.398			NA											19	146					7.07596e-05	7.54769e-05	0.006122	1	0
ZFHX4	79776	broad.mit.edu	37	8	77617486	77617486	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr8:77617486C>G	uc003yav.2	+	2	1550	c.1163C>G	c.(1162-1164)ACC>AGC	p.T388S	ZFHX4_uc003yat.1_Missense_Mutation_p.T388S|ZFHX4_uc003yau.1_Missense_Mutation_p.T388S|ZFHX4_uc003yaw.1_Missense_Mutation_p.T388S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	388						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGCGCGAGCACCTCGAGCTCA	0.532			NA								HNSCC(33;0.089)			6	53					0	0	0.004482	0	0
DPY19L4	286148	broad.mit.edu	37	8	95738658	95738658	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr8:95738658G>A	uc003ygx.2	+	2	240	c.116G>A	c.(115-117)AGA>AAA	p.R39K		NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	39						integral to membrane				ovary(2)	2	Breast(36;3.85e-06)					ATTCCTGAAAGAGCTCCAAAA	0.333			NA											8	61					0	0	0.00308	0	0
ZFPM2	23414	broad.mit.edu	37	8	106813279	106813279	+	Silent	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr8:106813279G>A	uc003ymd.2	+	8	992	c.969G>A	c.(967-969)GTG>GTA	p.V323V	ZFPM2_uc011lhs.1_Silent_p.V54V|uc003yme.1_5'Flank	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	323					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CTCTAGGAGTGAAAATGGAAG	0.418			NA											50	195					0	0	0.00361	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110476724	110476724	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr8:110476724G>A	uc003yne.2	+	49	7767	c.7663G>A	c.(7663-7665)GAT>AAT	p.D2555N		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2555	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCTTCTGAATGATGATGTGAC	0.443			NA								HNSCC(38;0.096)			14	79					0	0	0.001855	0	0
CSMD3	114788	broad.mit.edu	37	8	113246694	113246694	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr8:113246694C>A	uc003ynu.2	-	68	10799	c.10640G>T	c.(10639-10641)AGC>ATC	p.S3547I	CSMD3_uc003yns.2_Missense_Mutation_p.S2749I|CSMD3_uc003ynt.2_Missense_Mutation_p.S3507I|CSMD3_uc011lhx.1_Missense_Mutation_p.S3378I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3547	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGCTTCCTGGCTTTTATATAC	0.323			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			17	163					0.000566183	0.000593516	0.00499	1	0
MTBP	27085	broad.mit.edu	37	8	121463465	121463465	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr8:121463465G>C	uc003ypc.1	+	4	373	c.328G>C	c.(328-330)GAA>CAA	p.E110Q	MTBP_uc003ypb.1_Missense_Mutation_p.E110Q|MTBP_uc011lie.1_RNA	NM_022045	NP_071328	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53	110					cell cycle arrest					skin(2)|ovary(1)	3	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			AGATAAAATTGAAGATGTTCT	0.308			NA											15	48					0	0	0.003163	0	0
WDR67	93594	broad.mit.edu	37	8	124146378	124146378	+	Missense_Mutation	SNP	G	G	A	rs144947635	byFrequency	TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr8:124146378G>A	uc003ypp.1	+	17	2521	c.2431G>A	c.(2431-2433)GCT>ACT	p.A811T	WDR67_uc011lig.1_Intron|WDR67_uc011lih.1_Missense_Mutation_p.A701T|WDR67_uc003ypq.1_RNA|WDR67_uc003yps.1_Missense_Mutation_p.A445T|WDR67_uc003ypt.1_Missense_Mutation_p.A268T|WDR67_uc003ypu.1_Missense_Mutation_p.A268T	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	811	Potential.					centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			TCGAGAAATTGCTGCCACAGC	0.318			NA											15	122					0	0	0.006122	0	0
GSDMC	56169	broad.mit.edu	37	8	130789733	130789733	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr8:130789733C>T	uc003ysr.2	-	2	983	c.101G>A	c.(100-102)CGT>CAT	p.R34H		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	34						mitochondrion				ovary(2)|skin(1)	3						AACAAACTGACGTAATTTGGT	0.403			NA											27	145					0	0	0.005443	0	0
GSDMD	79792	broad.mit.edu	37	8	144642079	144642079	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr8:144642079C>T	uc010mfe.2	+	6	1053	c.350C>T	c.(349-351)TCA>TTA	p.S117L	uc003yye.2_5'Flank|GSDMD_uc003yyf.2_Missense_Mutation_p.S165L|GSDMD_uc003yyi.2_Missense_Mutation_p.S117L|GSDMD_uc003yyg.2_Missense_Mutation_p.S117L|GSDMD_uc003yyh.2_Intron	NM_024736	NP_079012	P57764	GSDMD_HUMAN	gasdermin D	117											0						TCCAGCACCTCAATGAATGTG	0.557			NA											12	48					0	0	0.001855	0	0
OPLAH	26873	broad.mit.edu	37	8	145106271	145106271	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr8:145106271G>A	uc003zar.3	-	28	3905	c.3823C>T	c.(3823-3825)CAC>TAC	p.H1275Y		NM_017570	NP_060040	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	1275							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding				0	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	ACGCTGCCGTGCTCGGGAAAG	0.682			NA											6	20					0	0	0.001984	0	0
CNTLN	54875	broad.mit.edu	37	9	17298312	17298312	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr9:17298312G>T	uc003zmz.2	+	7	1134	c.1108G>T	c.(1108-1110)GAA>TAA	p.E370*	CNTLN_uc003zmx.3_Nonsense_Mutation_p.E370*|CNTLN_uc003zmy.2_Nonsense_Mutation_p.E370*|CNTLN_uc010mio.2_Nonsense_Mutation_p.E49*	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	370						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		GAGAAATCAGGAAGATGTTCA	0.343			NA											14	60					2.32078e-09	2.65233e-09	0.003163	1	0
UBAP2	55833	broad.mit.edu	37	9	33963754	33963754	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr9:33963754G>C	uc003ztq.1	-	9	828	c.715C>G	c.(715-717)CTG>GTG	p.L239V	UBAP2_uc011loc.1_Missense_Mutation_p.L148V|UBAP2_uc011lod.1_Translation_Start_Site|UBAP2_uc011loe.1_Intron|UBAP2_uc011lof.1_Missense_Mutation_p.L164V|UBAP2_uc011log.1_Missense_Mutation_p.L185V|UBAP2_uc003ztr.2_Missense_Mutation_p.L111V	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	239										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		TTGTTTGACAGATCCTGAGCT	0.284			NA											12	86					0	0	0.004007	0	0
ROD1	9991	broad.mit.edu	37	9	115024748	115024748	+	Silent	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr9:115024748G>C	uc004bfw.2	-	6	754	c.567C>G	c.(565-567)CTC>CTG	p.L189L	ROD1_uc004bfv.2_Silent_p.L195L|ROD1_uc004bfx.2_Silent_p.L192L|ROD1_uc011lwu.1_Silent_p.L161L|ROD1_uc004bfy.2_Silent_p.L94L|ROD1_uc004bfz.2_Silent_p.L161L	NM_005156	NP_005147	O95758	ROD1_HUMAN	ROD1 regulator of differentiation 1 isoform 1	189	RRM 2.				anatomical structure morphogenesis|mRNA processing	nucleus	nucleotide binding|RNA binding			skin(1)	1						CAGGGTAAAAGAGGTTTTCAA	0.433			NA											36	119					0	0	0.003755	0	0
TMEM8C	389827	broad.mit.edu	37	9	136380685	136380685	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr9:136380685G>T	uc011mdk.1	-	4	444	c.444C>A	c.(442-444)AGC>AGA	p.S148R		NM_001080483	NP_001073952	A6NI61	TMM8C_HUMAN	transmembrane protein 8C	148						integral to membrane					0						GGGTGTAGACGCTCTTGTCTG	0.597			NA											18	75					2.37509e-13	2.77703e-13	0.010504	1	0
PNPLA7	375775	broad.mit.edu	37	9	140441330	140441330	+	Silent	SNP	G	G	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr9:140441330G>A	uc004cnf.2	-	3	487	c.150C>T	c.(148-150)TTC>TTT	p.F50F	PNPLA7_uc010ncj.1_Silent_p.F75F	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	50					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		CTCTCTTCCGGAACCGGTACT	0.612			NA											21	85					0	0	0.003954	0	0
CACNA1B	774	broad.mit.edu	37	9	140870387	140870387	+	Silent	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr9:140870387C>G	uc004cog.2	+	12	1717	c.1572C>G	c.(1570-1572)CTC>CTG	p.L524L	CACNA1B_uc011mfd.1_Silent_p.L55L	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	524	Helical; Name=S2 of repeat II; (Potential).|II.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TCCTGGGTCTCTTCCTCACAG	0.567			NA											8	28					0	0	0.004482	0	0
CACNA1B	774	broad.mit.edu	37	9	140919511	140919511	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr9:140919511C>T	uc004cog.2	+	20	3318	c.3173C>T	c.(3172-3174)GCA>GTA	p.A1058V	CACNA1B_uc011mfd.1_Missense_Mutation_p.A588V|CACNA1B_uc004coi.2_Missense_Mutation_p.A268V	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	1058	Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CCAGAGGATGCAGACAATCAG	0.592			NA											7	37					0	0	0.004482	0	0
KLHL15	80311	broad.mit.edu	37	X	24006555	24006555	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chrX:24006555C>G	uc004dba.3	-	4	1554	c.1298G>C	c.(1297-1299)GGA>GCA	p.G433A		NM_030624	NP_085127	Q96M94	KLH15_HUMAN	kelch-like 15	433	Kelch 3.									ovary(1)|breast(1)	2						TGAGGTGATTCCACCGGTGAT	0.453			NA											66	82					0	0	0.00361	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29972752	29972752	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chrX:29972752G>C	uc004dby.2	+	10	1823	c.1315G>C	c.(1315-1317)GAA>CAA	p.E439Q		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	439	Cytoplasmic (Potential).|TIR.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						TGATATGCTTGAAAAGCATTA	0.373			NA											27	34					0	0	0.007291	0	0
CACNA1F	778	broad.mit.edu	37	X	49086776	49086776	+	Silent	SNP	T	T	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chrX:49086776T>A	uc004dnb.2	-	6	785	c.723A>T	c.(721-723)GCA>GCT	p.A241A	CACNA1F_uc010nip.2_Silent_p.A241A	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	241	I.|Helical; Name=S5 of repeat I; (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	GCACGAGCAGTGCAATGTGCA	0.557			NA											12	10					0	0	0.001855	0	0
HEPH	9843	broad.mit.edu	37	X	65476147	65476147	+	Silent	SNP	T	T	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chrX:65476147T>A	uc011moz.1	+	17	2940	c.2880T>A	c.(2878-2880)ACT>ACA	p.T960T	HEPH_uc004dwn.2_Silent_p.T960T|HEPH_uc004dwo.2_Silent_p.T690T|HEPH_uc010nkr.2_Silent_p.T768T|HEPH_uc011mpa.1_Silent_p.T960T|HEPH_uc010nks.2_Silent_p.T249T	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	957	Extracellular (Potential).|Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						AGGATGAAACTTTCTTGGAGA	0.398			NA											4	71					0	0	0.009096	0	0
MED12	9968	broad.mit.edu	37	X	70351937	70351937	+	Silent	SNP	C	C	G			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chrX:70351937C>G	uc004dyy.2	+	30	4333	c.4134C>G	c.(4132-4134)CTC>CTG	p.L1378L	MED12_uc011mpq.1_Silent_p.L1378L|MED12_uc004dyz.2_Silent_p.L1378L|MED12_uc004dza.2_Silent_p.L1225L|MED12_uc010nla.2_Silent_p.L4L	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1378					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TGAACTCCCTCTTGGAGAACA	0.512			NA											17	39					0	0	0.010504	0	0
MED12	9968	broad.mit.edu	37	X	70352266	70352266	+	Silent	SNP	C	C	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chrX:70352266C>A	uc004dyy.2	+	31	4492	c.4293C>A	c.(4291-4293)CTC>CTA	p.L1431L	MED12_uc011mpq.1_Silent_p.L1431L|MED12_uc004dyz.2_Silent_p.L1431L|MED12_uc004dza.2_Silent_p.L1278L|MED12_uc010nla.2_Silent_p.L57L	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1431					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TGGCCCCCCTCATTGCTAAAC	0.557			NA											13	29					7.93312e-07	8.70639e-07	0.00245	1	0
PLP1	5354	broad.mit.edu	37	X	103044264	103044264	+	Silent	SNP	C	C	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chrX:103044264C>T	uc010nov.2	+	7	979	c.699C>T	c.(697-699)TTC>TTT	p.F233F	RAB9B_uc004eli.1_Intron|PLP1_uc004elk.2_Silent_p.F233F|PLP1_uc004elj.2_Silent_p.F198F|PLP1_uc011msf.1_Silent_p.F178F|PLP1_uc010nox.2_Silent_p.F187F	NM_001128834	NP_001122306	P60201	MYPR_HUMAN	proteolipid protein 1 isoform 1	233	Extracellular (Probable).				cell death|synaptic transmission	integral to membrane				ovary(1)	1						TCCTGCAGTTCCAAATGACCT	0.413			NA											34	56					0	0	0.002836	0	0
ODZ1	10178	broad.mit.edu	37	X	123870875	123870875	+	Silent	SNP	G	G	T			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chrX:123870875G>T	uc004euj.2	-	4	772	c.708C>A	c.(706-708)ACC>ACA	p.T236T	ODZ1_uc011muj.1_Silent_p.T236T|ODZ1_uc010nqy.2_Silent_p.T236T	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	236	Teneurin N-terminal.|Cytoplasmic (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CCTGCGTGCTGGTTGGGGGAG	0.557			NA											33	186					2.75727e-19	3.33949e-19	0.004878	1	0
ATP11C	286410	broad.mit.edu	37	X	138832284	138832284	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chrX:138832284T>A	uc004faz.2	-	24	2836	c.2737A>T	c.(2737-2739)ATG>TTG	p.M913L	ATP11C_uc004fax.2_Missense_Mutation_p.M121L|ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Missense_Mutation_p.M913L	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	913	Helical; (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					ATATTGTACATTGTAAGGTAA	0.383			NA											24	49					0	0	0.002299	0	0
NOTCH2	4853	broad.mit.edu	37	1	120467956	120467957	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr1:120467956_120467957insA	uc001eik.2	-	25	4738_4739	c.4482_4483insT	c.(4480-4485)TTTGAAfs	p.F1494fs		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	1494_1495	Negative regulatory region (NRR).|LNR 2.|Extracellular (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCCTGGCATTCAAAGTTGTCAA	0.51			NA	N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				34	450	---	---	---	---	NA	NA	NA	NA	NA
AHNAK	79026	broad.mit.edu	37	11	62301532	62301544	+	Frame_Shift_Del	DEL	CTCATCATCCCCG	CTCATCATCCCCG	-	rs117532364	by1000genomes	TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	CTCATCATCCCCG	CTCATCATCCCCG	-	-	CTCATCATCCCCG	CTCATCATCCCCG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr11:62301532_62301544delCTCATCATCCCCG	uc001ntl.2	-	5	645_657	c.345_357delCGGGGATGATGAG	c.(343-357)AGCGGGGATGATGAGfs	p.S115fs	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	115_119					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GCTGGTACTCCTCATCATCCCCGCTCTGCAGAA	0.596			NA											13	81	---	---	---	---	NA	NA	NA	NA	NA
DDX54	79039	broad.mit.edu	37	12	113601889	113601891	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	CCT	CCT	-	-	CCT	CCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr12:113601889_113601891delCCT	uc001tup.2	-	15	1947_1949	c.1919_1921delAGG	c.(1918-1923)GAGGCG>GCG	p.E640del	DDX54_uc001tuq.3_In_Frame_Del_p.E640del	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	640	Interaction with nuclear receptors.				estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						ctctctcccgcctcctcctcctc	0.512			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
RAB40C	57799	broad.mit.edu	37	16	677517	677522	+	In_Frame_Del	DEL	CGGGGG	CGGGGG	-			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	CGGGGG	CGGGGG	-	-	CGGGGG	CGGGGG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr16:677517_677522delCGGGGG	uc002chr.2	+	6	857_862	c.741_746delCGGGGG	c.(739-747)GCCGGGGGC>GCC	p.GG250del	RAB40C_uc002chq.2_In_Frame_Del_p.GG231del|WFIKKN1_uc002chs.1_5'Flank	NM_021168	NP_066991	Q96S21	RB40C_HUMAN	RAB40C, member RAS oncogene family	250_251					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0		Hepatocellular(780;0.0218)				CCAGCGGGGCCGGGGGCGGCGGCAGC	0.641	Melanoma(123;1631 1690 28262 44104 44957)		NA											48	215	---	---	---	---	NA	NA	NA	NA	NA
C20orf4	25980	broad.mit.edu	37	20	34828224	34828229	+	In_Frame_Del	DEL	TGGAGA	TGGAGA	-	rs138100023		TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	TGGAGA	TGGAGA	-	-	TGGAGA	TGGAGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr20:34828224_34828229delTGGAGA	uc002xfc.1	+	2	527_532	c.434_439delTGGAGA	c.(433-441)GTGGAGAAG>GAG	p.145_147VEK>E	C20orf4_uc002xfd.1_In_Frame_Del_p.145_147VEK>E|C20orf4_uc002xfe.1_In_Frame_Del_p.145_147VEK>E	NM_015511	NP_056326	Q9Y312	CT004_HUMAN	hypothetical protein LOC25980	145_147											0	Breast(12;0.0162)	Myeloproliferative disorder(115;0.0393)				GAAGCCACAGTGGAGAAGCTACAGCC	0.568			NA											26	255	---	---	---	---	NA	NA	NA	NA	NA
MFSD8	256471	broad.mit.edu	37	4	128842758	128842758	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr4:128842758delA	uc003ifp.2	-	12	1434	c.1271delT	c.(1270-1272)GTGfs	p.V424fs	MFSD8_uc011cgu.1_Frame_Shift_Del_p.V379fs|MFSD8_uc011cgv.1_3'UTR	NM_152778	NP_689991	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing	424	Helical; (Potential).				cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2						TCCTATTAGCACAGCTGATGT	0.448			NA											38	135	---	---	---	---	NA	NA	NA	NA	NA
PLEKHG1	57480	broad.mit.edu	37	6	151151947	151151951	+	Frame_Shift_Del	DEL	CCTCC	CCTCC	-			TCGA-44-2662-01A-01D-0969-08	TCGA-44-2662-10A-01D-0969-08	CCTCC	CCTCC	-	-	CCTCC	CCTCC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	773139df-8eb3-44e5-b434-3e7a43a9a9e0	0473acaa-cd98-4550-9ccf-e2da3a4843b0	g.chr6:151151947_151151951delCCTCC	uc003qny.1	+	16	2012_2016	c.1700_1704delCCTCC	c.(1699-1704)TCCTCCfs	p.S567fs	PLEKHG1_uc011eel.1_Frame_Shift_Del_p.S607fs|PLEKHG1_uc011eem.1_Frame_Shift_Del_p.S626fs|PLEKHG1_uc003qnz.2_Frame_Shift_Del_p.S567fs	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	567_568					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		CCGTCATTTTCCTCCTCAGATCTGA	0.517			NA											36	183	---	---	---	---	NA	NA	NA	NA	NA
