Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TTLL10	254173	broad.mit.edu	37	1	1115671	1115671	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:1115671A>T	uc001acy.2	+	6	608	c.457A>T	c.(457-459)ACC>TCC	p.T153S	uc001acx.1_5'Flank|TTLL10_uc010nyg.1_Missense_Mutation_p.T153S|TTLL10_uc001acz.1_Missense_Mutation_p.T80S	NM_001130045	NP_001123517	Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	153					protein modification process		ATP binding|tubulin-tyrosine ligase activity			large_intestine(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GCCCCACAGCACCCGGCCGGG	0.697			NA											3	7					0	0	0.004672	0	0
KIAA1751	85452	broad.mit.edu	37	1	1905589	1905589	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:1905589G>T	uc001aim.1	-	7	705	c.549C>A	c.(547-549)TTC>TTA	p.F183L	KIAA1751_uc009vkz.1_Missense_Mutation_p.F183L	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	hypothetical protein LOC85452	183										pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		CAGCTGTCCGGAAGGCCTCGA	0.667			NA											8	45					0.000157383	0.000204987	0.00308	1	0
PRAMEF2	65122	broad.mit.edu	37	1	12918992	12918992	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:12918992C>A	uc001aum.1	+	2	215	c.128C>A	c.(127-129)GCC>GAC	p.A43D		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	43											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTCAGGGAGGCCTTCAGCAGG	0.607			NA											31	166					1.88708e-17	3.29979e-17	0.008361	1	0
ATP13A2	23400	broad.mit.edu	37	1	17322790	17322790	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:17322790G>A	uc001baa.2	-	14	1502	c.1312C>T	c.(1312-1314)CTC>TTC	p.L438F	ATP13A2_uc001bab.2_Missense_Mutation_p.L433F|ATP13A2_uc001bac.2_Missense_Mutation_p.L433F|ATP13A2_uc009vpa.1_Missense_Mutation_p.L114F|ATP13A2_uc001bad.1_Missense_Mutation_p.L151F	NM_022089	NP_071372	Q9NQ11	AT132_HUMAN	ATPase type 13A2 isoform 1	438	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		ATGGTGCCGAGGAGAGCTGTG	0.657			NA											4	75					0	0	0.000602	0	0
ACTL8	81569	broad.mit.edu	37	1	18152740	18152740	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:18152740T>C	uc001bat.2	+	3	1043	c.827T>C	c.(826-828)ATT>ACT	p.I276T		NM_030812	NP_110439	Q9H568	ACTL8_HUMAN	actin-like 8	276						cytoplasm|cytoskeleton				ovary(4)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		CCACGGGCCATTGTGGAATCC	0.662			NA									OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	55					0	0	0.008291	0	0
ASAP3	55616	broad.mit.edu	37	1	23759638	23759638	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:23759638G>A	uc001bha.2	-	22	2379	c.2255C>T	c.(2254-2256)CCC>CTC	p.P752L	ASAP3_uc001bgy.1_Missense_Mutation_p.P256L|ASAP3_uc001bgz.1_RNA|ASAP3_uc010odz.1_Missense_Mutation_p.P642L|ASAP3_uc010oea.1_Missense_Mutation_p.P743L|ASAP3_uc001bhb.2_Missense_Mutation_p.P275L	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	752					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						CAAGGGCGGGGGACAGTCCTC	0.582			NA											8	134					0	0	0.004482	0	0
ZNF683	257101	broad.mit.edu	37	1	26688417	26688417	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:26688417G>T	uc001bmg.1	-	7	1418	c.1300C>A	c.(1300-1302)CGC>AGC	p.R434S	ZNF683_uc001bmh.1_Missense_Mutation_p.R414S|ZNF683_uc009vsj.1_Missense_Mutation_p.R414S	NM_173574	NP_775845	Q8IZ20	ZN683_HUMAN	zinc finger protein 683	434	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		TGGGTGAAGCGACTCCGGCAG	0.662			NA											16	60					3.45872e-05	4.67814e-05	0.004007	1	0
GPN2	54707	broad.mit.edu	37	1	27215499	27215499	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:27215499G>A	uc001bnd.1	-	2	811	c.529C>T	c.(529-531)CTT>TTT	p.L177F		NM_018066	NP_060536	Q9H9Y4	GPN2_HUMAN	ATP binding domain 1 family, member B	177							GTP binding				0						ATCTTGGAAAGGAGGTTGATG	0.532			NA											15	270					0	0	0.006122	0	0
MACF1	23499	broad.mit.edu	37	1	39783000	39783000	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:39783000C>T	uc010ois.1	+	30	3923	c.3718C>T	c.(3718-3720)CTG>TTG	p.L1240L	MACF1_uc001cda.1_Silent_p.L1148L|MACF1_uc001cdc.1_Silent_p.L327L|MACF1_uc009vvq.1_Silent_p.L297L|MACF1_uc001cdb.1_Silent_p.L327L	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1240					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGAGCGAAATCTGGATTTGGA	0.532			NA											7	53					0	0	0.004482	0	0
BMP8A	353500	broad.mit.edu	37	1	39991331	39991331	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:39991331T>C	uc001cdi.2	+	7	1416	c.1070T>C	c.(1069-1071)ATG>ACG	p.M357T	PPIEL_uc001cdj.1_RNA|PPIEL_uc001cdk.2_Intron	NM_181809	NP_861525	Q7Z5Y6	BMP8A_HUMAN	bone morphogenetic protein 8A precursor	357					cartilage development|cell differentiation|growth|ossification	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(20;2.08e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;9.69e-19)|Epithelial(16;9.34e-17)|all cancers(16;1.73e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GTGCACCTGATGAAGCCAAAC	0.637			NA											10	39					0	0	0.008291	0	0
RLF	6018	broad.mit.edu	37	1	40706012	40706012	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:40706012C>T	uc001cfc.3	+	8	5669	c.5638C>T	c.(5638-5640)CAT>TAT	p.H1880Y	RLF_uc001cfd.3_Missense_Mutation_p.H1571Y	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	1880					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			AAAACAGCTTCATTATCTTCG	0.393			NA											10	84					0	0	0.006214	0	0
HIVEP3	59269	broad.mit.edu	37	1	42049802	42049802	+	Missense_Mutation	SNP	C	C	A	rs147878871		TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:42049802C>A	uc001cgz.3	-	4	1880	c.667G>T	c.(667-669)GGC>TGC	p.G223C	HIVEP3_uc001cha.3_Missense_Mutation_p.G223C|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	223	C2H2-type 2.|No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).|ZAS1.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CCACAGGGGCCGCAGGGGTAG	0.602			NA											7	55					5.18039e-06	7.1912e-06	0.00308	1	0
KANK4	163782	broad.mit.edu	37	1	62703976	62703976	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:62703976C>T	uc001dah.3	-	10	3338	c.2961G>A	c.(2959-2961)GCG>GCA	p.A987A	KANK4_uc001dai.3_Silent_p.A359A|KANK4_uc001daf.3_Silent_p.A125A|KANK4_uc001dag.3_Silent_p.A343A	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	987	ANK 5.									ovary(3)|skin(2)|lung(1)	6						TGCCCTGCTCCGCGTGGGCTC	0.587			NA											8	65					0	0	0.004482	0	0
NEGR1	257194	broad.mit.edu	37	1	72058514	72058514	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:72058514C>A	uc001dfw.2	-	6	1026	c.926G>T	c.(925-927)AGC>ATC	p.S309I	NEGR1_uc001dfv.2_Missense_Mutation_p.S181I|NEGR1_uc010oqs.1_Missense_Mutation_p.S265I	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	309	Ig-like C2-type 3.				cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		AAGAGGCAGGCTCGCATTGGT	0.483			NA											19	147					8.34094e-07	1.19724e-06	0.008871	1	0
TNNI3K	51086	broad.mit.edu	37	1	74663994	74663994	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:74663994C>T	uc001dge.1	+	1	48	c.32C>T	c.(31-33)TCG>TTG	p.S11L	LRRIQ3_uc001dfy.3_5'Flank|LRRIQ3_uc001dfz.3_5'Flank|TNNI3K_uc001dgc.1_Missense_Mutation_p.S11L|TNNI3K_uc001dgd.2_Missense_Mutation_p.S11L|FPGT_uc010oqt.1_5'UTR|FPGT_uc010oqu.1_Missense_Mutation_p.S11L|FPGT_uc001dgb.1_Missense_Mutation_p.S11L|FPGT_uc010oqv.1_Missense_Mutation_p.S11L	NM_001112808	NP_001106279	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform a	Error:Variant_position_missing_in_Q59H18_after_alignment						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						CCGGAAGTATCGCTGCGAGAA	0.642			NA											11	30					0	0	0.000978	0	0
AK5	26289	broad.mit.edu	37	1	77763335	77763335	+	Silent	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:77763335G>A	uc001dhn.2	+	4	764	c.507G>A	c.(505-507)AAG>AAA	p.K169K	AK5_uc001dho.2_Silent_p.K143K|AK5_uc001dhm.1_Silent_p.K145K	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1	169					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						TATTAAGAAAGAAGATCCACA	0.388			NA											15	64					0	0	0.00245	0	0
AK5	26289	broad.mit.edu	37	1	77763337	77763337	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:77763337A>T	uc001dhn.2	+	4	766	c.509A>T	c.(508-510)AAG>ATG	p.K170M	AK5_uc001dho.2_Missense_Mutation_p.K144M|AK5_uc001dhm.1_Missense_Mutation_p.K146M	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1	170					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						TTAAGAAAGAAGATCCACAGT	0.388			NA											17	67					0	0	0.004007	0	0
IFI44	10561	broad.mit.edu	37	1	79128523	79128523	+	Silent	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:79128523T>A	uc001dip.3	+	8	1372	c.1248T>A	c.(1246-1248)GCT>GCA	p.A416A		NM_006417	NP_006408	Q8TCB0	IFI44_HUMAN	interferon-induced, hepatitis C-associated	416					response to virus	cytoplasm				ovary(1)|central_nervous_system(1)	2						TGCTATGGGCTGCAGATGACT	0.458			NA											17	110					0	0	0.007413	0	0
WDR63	126820	broad.mit.edu	37	1	85595688	85595688	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:85595688C>A	uc001dkt.2	+	22	2616	c.2425C>A	c.(2425-2427)CAC>AAC	p.H809N	WDR63_uc009wcl.2_Missense_Mutation_p.H770N	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	809										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		AAGTGTCAACCACTATTTTGA	0.418			NA											38	247					9.85521e-28	1.80299e-27	0.00623	1	0
GBP5	115362	broad.mit.edu	37	1	89735201	89735201	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:89735201A>G	uc001dnc.2	-	3	575	c.38T>C	c.(37-39)CTC>CCC	p.L13P	GBP5_uc001dnd.2_Missense_Mutation_p.L13P|GBP5_uc001dne.1_Missense_Mutation_p.L13P	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	13						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		GTTCTCGATGAGGCACATGGG	0.478			NA											14	201					0	0	0.003163	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94668512	94668512	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:94668512C>T	uc001dqj.3	-	10	1285	c.916G>A	c.(916-918)GAA>AAA	p.E306K	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dql.2_Missense_Mutation_p.E306K	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	306	Potential.				Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TCTTTTATTTCTTTCCTTTGT	0.299			NA											12	131					0	0	0.001855	0	0
RWDD3	25950	broad.mit.edu	37	1	95712169	95712169	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:95712169G>A	uc009wdu.2	+	3	721	c.645G>A	c.(643-645)ATG>ATA	p.M215I	RWDD3_uc001drf.3_Intron|RWDD3_uc001drh.3_Missense_Mutation_p.D185N|RWDD3_uc009wdv.2_RNA|RWDD3_uc001drg.3_RNA|RWDD3_uc001dri.3_Missense_Mutation_p.D200N	NM_015485	NP_056300	Q9Y3V2	RWDD3_HUMAN	RWD domain containing 3 isoform a	215						cytoplasm|nucleus	protein binding			ovary(1)	1		all_epithelial(167;5.99e-05)|all_lung(203;0.00168)|Lung NSC(277;0.00769)		all cancers(265;0.112)|Epithelial(280;0.229)		AAGAGAAAATGATTAGTGTAC	0.313			NA											7	70					0	0	0.001984	0	0
SLC16A1	6566	broad.mit.edu	37	1	113456568	113456568	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:113456568G>C	uc001ecx.2	-	5	2280	c.1448C>G	c.(1447-1449)TCT>TGT	p.S483C	SLC16A1_uc001ecy.2_Missense_Mutation_p.S483C	NM_003051	NP_003042	P53985	MOT1_HUMAN	solute carrier family 16, member 1	483	Cytoplasmic (Potential).				blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	CTGGTCCGGAGATTCTGCTGC	0.468			NA											36	205					0	0	0.005524	0	0
NOTCH2	4853	broad.mit.edu	37	1	120510124	120510124	+	Nonsense_Mutation	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:120510124G>C	uc001eik.2	-	8	1641	c.1385C>G	c.(1384-1386)TCA>TGA	p.S462*	NOTCH2_uc001eil.2_Nonsense_Mutation_p.S462*|NOTCH2_uc001eim.3_Nonsense_Mutation_p.S379*	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	462	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCAGGGGTCTGAATGGCACTC	0.507			NA	N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				7	140					0	0	0.00308	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058337	152058337	+	Silent	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:152058337C>G	uc001ezo.1	-	3	1886	c.1821G>C	c.(1819-1821)CTG>CTC	p.L607L		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	607							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CCACTGCCTCCAGAGCTCTGT	0.537			NA											36	136					0	0	0.002836	0	0
HRNR	388697	broad.mit.edu	37	1	152192118	152192118	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:152192118C>T	uc001ezt.1	-	3	2063	c.1987G>A	c.(1987-1989)GGC>AGC	p.G663S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	663	6.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCATGTCGGCCGCGACTAGGA	0.592			NA											57	258					0	0	0.00361	0	0
FLG2	388698	broad.mit.edu	37	1	152326042	152326042	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:152326042C>G	uc001ezw.3	-	3	4293	c.4220G>C	c.(4219-4221)GGA>GCA	p.G1407A	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1407							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTGGACTGTCCATGACCAGA	0.527			NA											33	402					0	0	0.001786	0	0
LCE3B	353143	broad.mit.edu	37	1	152586476	152586476	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:152586476C>A	uc010pds.1	+	1	190	c.190C>A	c.(190-192)CAC>AAC	p.H64N		NM_178433	NP_848520	Q5TA77	LCE3B_HUMAN	late cornified envelope 3B	64	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0313)|Kidney(5;0.0367)		CTGCAGGTCCCACCGATGCCG	0.662			NA											54	70					5.13769e-22	9.21291e-22	0.00361	1	0
TPM3	7170	broad.mit.edu	37	1	154141852	154141852	+	Silent	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:154141852G>C	uc001fec.1	-	9	898	c.783C>G	c.(781-783)CTC>CTG	p.L261L	TPM3_uc001fdx.1_Intron|TPM3_uc010pei.1_Intron|TPM3_uc001fdy.1_Intron|TPM3_uc001fdz.1_Intron|TPM3_uc001fea.1_Intron|TPM3_uc001feb.1_Intron|TPM3_uc010pej.1_Intron|TPM3_uc009wor.2_Intron|TPM3_uc001fed.1_Silent_p.L224L	NM_152263	NP_689476	P06753	TPM3_HUMAN	tropomyosin 3 isoform 1	260	By similarity.				cellular component movement|muscle filament sliding|regulation of muscle contraction	cytosol|muscle thin filament tropomyosin|stress fiber	actin binding		TPM3/ALK(33)	haematopoietic_and_lymphoid_tissue(22)|soft_tissue(11)|skin(1)	34	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)					TCTGGGCATAGAGCTCATCTG	0.493			NA	T	NTRK1|ALK	papillary thyroid|ALCL								3	51					0	0	0.000248	0	0
FAM189B	10712	broad.mit.edu	37	1	155218083	155218083	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:155218083C>G	uc001fjm.2	-	11	2197	c.1591G>C	c.(1591-1593)GAA>CAA	p.E531Q	RAG1AP1_uc010pey.1_Intron|FAM189B_uc009wql.2_Missense_Mutation_p.E333Q|FAM189B_uc001fjn.2_Missense_Mutation_p.E435Q|FAM189B_uc001fjo.2_Missense_Mutation_p.E513Q|FAM189B_uc001fjp.2_RNA	NM_006589	NP_006580	P81408	F189B_HUMAN	hypothetical protein LOC10712 isoform a	531						integral to membrane	WW domain binding			ovary(1)|breast(1)	2						AGGCAGGCTTCAGAGCAGAGC	0.617			NA											5	63					0	0	0.001984	0	0
FCGR2B	2213	broad.mit.edu	37	1	161647156	161647156	+	Splice_Site	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:161647156G>T	uc001gaz.1	+	7	947	c.855_splice	c.e7+1	p.G285_splice	FCGR2B_uc001gay.1_Splice_Site_p.G284_splice|FCGR2B_uc001gba.1_Splice_Site_p.G265_splice|FCGR2B_uc001gbb.1_Splice_Site_p.G266_splice|FCGR2B_uc009wun.1_Splice_Site_p.G278_splice	NM_004001	NP_003992	P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor						immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CAAAGTTGGGGTGAGTGATCC	0.537			NA	T	?	ALL								22	90					2.32416e-17	4.05287e-17	0.002299	1	0
OLFML2B	25903	broad.mit.edu	37	1	161953507	161953507	+	Silent	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:161953507G>A	uc001gbu.2	-	8	2635	c.2211C>T	c.(2209-2211)GAC>GAT	p.D737D	OLFML2B_uc001gbt.2_Silent_p.D220D|OLFML2B_uc010pkq.1_Silent_p.D738D	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	737	Olfactomedin-like.									skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			GGTGGCCATTGTCCCAGGCAT	0.507			NA											53	129					0	0	0.00361	0	0
KIFAP3	22920	broad.mit.edu	37	1	170015946	170015946	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:170015946C>T	uc001ggv.2	-	3	497	c.226G>A	c.(226-228)GAA>AAA	p.E76K	KIFAP3_uc010ply.1_5'UTR|KIFAP3_uc001ggw.1_Missense_Mutation_p.E32K	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	76					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTACATTCTTCAACCACCTTC	0.373			NA											16	99					0	0	0.003163	0	0
C1orf129	80133	broad.mit.edu	37	1	170959103	170959103	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:170959103G>T	uc001ghg.2	+	11	1117	c.987G>T	c.(985-987)AAG>AAT	p.K329N	C1orf129_uc009wvy.2_Missense_Mutation_p.K136N|C1orf129_uc010plz.1_Missense_Mutation_p.K329N	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	329							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CACCCAAGAAGGTCATCTTTC	0.468			NA											18	69					3.41278e-10	5.41426e-10	0.00499	1	0
TNR	7143	broad.mit.edu	37	1	175375383	175375383	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:175375383G>T	uc001gkp.1	-	1	549	c.468C>A	c.(466-468)AAC>AAA	p.N156K	TNR_uc009wwu.1_Missense_Mutation_p.N156K|TNR_uc010pmz.1_Missense_Mutation_p.N156K	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	156	Cys-rich.|Potential.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					AGCAGTTGGCGTTGCACTGGT	0.627			NA											17	81					0.000958276	0.00122296	0.007413	1	0
CEP350	9857	broad.mit.edu	37	1	179989900	179989900	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:179989900G>T	uc001gnt.2	+	12	3374	c.2991G>T	c.(2989-2991)GAG>GAT	p.E997D	CEP350_uc009wxl.2_Missense_Mutation_p.E996D|CEP350_uc001gnu.2_Missense_Mutation_p.E831D	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	997						centrosome|nucleus|spindle				ovary(4)	4						CTGAAGAAGAGGGAGACCAGG	0.418			NA											26	160					1.55469e-16	2.65979e-16	0.00333	1	0
FAM5C	339479	broad.mit.edu	37	1	190067362	190067362	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:190067362T>A	uc001gse.1	-	8	2319	c.2087A>T	c.(2086-2088)CAG>CTG	p.Q696L	FAM5C_uc010pot.1_Missense_Mutation_p.Q594L	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	696						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TGCTGAATCCTGGGATCCCTG	0.463			NA											45	99					0	0	0.002222	0	0
CFH	3075	broad.mit.edu	37	1	196696041	196696041	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:196696041G>T	uc001gtj.3	+	14	2447	c.2207G>T	c.(2206-2208)GGA>GTA	p.G736V		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	736	Sushi 12.				complement activation, alternative pathway	extracellular space		p.G736G(1)		skin(4)|ovary(1)|breast(1)	6						TGTATTCATGGAGTATGGACC	0.353			NA											20	87					0.000175454	0.000228054	0.001523	1	0
F13B	2165	broad.mit.edu	37	1	197031046	197031046	+	Silent	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:197031046A>G	uc001gtt.1	-	3	363	c.319T>C	c.(319-321)TTG>CTG	p.L107L		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	107	Sushi 2.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						ATTTTATACAATAACTTTACA	0.368			NA											10	62					0	0	0.008291	0	0
CRB1	23418	broad.mit.edu	37	1	197326027	197326027	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:197326027G>A	uc001gtz.2	+	5	1190	c.1055G>A	c.(1054-1056)GGG>GAG	p.G352E	CRB1_uc010poz.1_Missense_Mutation_p.G283E|CRB1_uc001gty.1_Missense_Mutation_p.G352E|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.G240E|CRB1_uc010ppb.1_Missense_Mutation_p.G352E|CRB1_uc010ppc.1_RNA	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	352	Extracellular (Potential).|EGF-like 9.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						CAGTCCAATGGGGAATGTGTG	0.473			NA											6	87					0	0	0.001168	0	0
CAMSAP1L1	23271	broad.mit.edu	37	1	200827089	200827089	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:200827089A>G	uc001gvl.2	+	18	4642	c.4372A>G	c.(4372-4374)ACT>GCT	p.T1458A	CAMSAP1L1_uc001gvk.2_Missense_Mutation_p.T1447A|CAMSAP1L1_uc001gvm.2_Missense_Mutation_p.T1431A	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	1458	CKK.					cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						ACCCGCTAAAACTTTATCTGC	0.373			NA											64	166					0	0	0.00361	0	0
ATP2B4	493	broad.mit.edu	37	1	203652479	203652479	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:203652479G>T	uc001gzw.2	+	2	1030	c.146G>T	c.(145-147)GGA>GTA	p.G49V	ATP2B4_uc001gzv.2_Missense_Mutation_p.G49V|ATP2B4_uc009xaq.2_Missense_Mutation_p.G49V	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	49	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GTCCACTATGGAGGTGTACAG	0.512			NA											18	132					2.48551e-13	4.1079e-13	0.00499	1	0
FAIM3	9214	broad.mit.edu	37	1	207087253	207087253	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:207087253C>T	uc001hey.2	-	2	403	c.224G>A	c.(223-225)CGA>CAA	p.R75Q	FAIM3_uc010prz.1_Intron|FAIM3_uc010psa.1_Silent_p.P18P|FAIM3_uc010psb.1_Missense_Mutation_p.R75Q	NM_005449	NP_005440	O60667	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3 isoform a	75	Ig-like.|Extracellular (Potential).				anti-apoptosis|cellular defense response	integral to membrane				central_nervous_system(1)	1	Breast(84;0.201)					CAGAGTAACTCGGCCCTTGTA	0.517			NA											15	223					0	0	0.004007	0	0
IARS2	55699	broad.mit.edu	37	1	220287726	220287726	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:220287726G>C	uc001hmc.2	+	12	1654	c.1550G>C	c.(1549-1551)CGG>CCG	p.R517P		NM_018060	NP_060530	Q9NSE4	SYIM_HUMAN	mitochondrial isoleucine tRNA synthetase	517					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			ovary(2)|skin(2)	4				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	ATGGACAGGCGGCCATATTGG	0.383			NA											44	111					0	0	0.002522	0	0
C1orf55	163859	broad.mit.edu	37	1	226187006	226187006	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:226187006T>A	uc001hpu.3	-	1	61	c.8A>T	c.(7-9)GAG>GTG	p.E3V	C1orf55_uc001hpv.2_Missense_Mutation_p.E3V	NM_152608	NP_689821	Q6IQ49	CA055_HUMAN	hypothetical protein LOC163859	3										lung(1)	1	Breast(184;0.197)					CGCCGCGGCCTCCGCCATGTC	0.677			NA											12	44					0	0	0.001368	0	0
URB2	9816	broad.mit.edu	37	1	229771885	229771885	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:229771885C>G	uc001hts.1	+	4	1661	c.1525C>G	c.(1525-1527)CAG>GAG	p.Q509E	URB2_uc009xfd.1_Missense_Mutation_p.Q509E	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	509						nucleolus				central_nervous_system(2)|ovary(1)	3						GCCTCCAAGTCAGATCCTGGA	0.582			NA											5	171					0	0	0.000602	0	0
COG2	22796	broad.mit.edu	37	1	230814766	230814766	+	Silent	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:230814766G>A	uc001htw.2	+	10	1285	c.1134G>A	c.(1132-1134)AAG>AAA	p.K378K	COG2_uc001htx.2_Silent_p.K378K|COG2_uc010pwc.1_Silent_p.K251K	NM_007357	NP_031383	Q14746	COG2_HUMAN	component of oligomeric golgi complex 2 isoform	378					Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity				0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				GCTTCAATAAGAAGTGGAACT	0.443			NA											4	71					0	0	0.000248	0	0
RYR2	6262	broad.mit.edu	37	1	237551419	237551419	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:237551419C>G	uc001hyl.1	+	10	829	c.709C>G	c.(709-711)CTG>GTG	p.L237V		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	237	Cytoplasmic (By similarity).|MIR 3.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CCTCAGGTTGCTGCATGGACA	0.408			NA											6	34					0	0	0.00308	0	0
RYR2	6262	broad.mit.edu	37	1	237806644	237806644	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:237806644G>T	uc001hyl.1	+	48	7359	c.7239G>T	c.(7237-7239)AAG>AAT	p.K2413N		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2413	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATGCCGGGAAGGGAGAAGCCA	0.413			NA											51	156					1.39843e-22	2.52195e-22	0.00361	1	0
OR6F1	343169	broad.mit.edu	37	1	247875386	247875386	+	Silent	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:247875386G>T	uc001idj.1	-	1	672	c.672C>A	c.(670-672)ACC>ACA	p.T224T		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TCCTGAGGATGGTGCTGATGA	0.527			NA											29	106					9.39395e-14	1.57311e-13	0.00632	1	0
OR2M1P	388762	broad.mit.edu	37	1	248285818	248285818	+	Missense_Mutation	SNP	T	T	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:248285818T>G	uc001idy.1	+	1	381	c.381T>G	c.(379-381)TTT>TTG	p.F127L		NR_002141				RecName: Full=Olfactory receptor 2M5;												0						CATCAATATTTGAAAAGGTTA	0.408			NA											52	271					0	0	0.00361	0	0
OR2M3	127062	broad.mit.edu	37	1	248366686	248366686	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:248366686C>A	uc010pzg.1	+	1	317	c.317C>A	c.(316-318)TCA>TAA	p.S106*		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	106	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TTCTATACATCACTGCTTGGC	0.473			NA											65	506					1.31726e-23	2.38919e-23	0.00361	1	0
OR2T4	127074	broad.mit.edu	37	1	248524995	248524995	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:248524995A>G	uc001ieh.1	+	1	113	c.113A>G	c.(112-114)CAC>CGC	p.H38R		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	38	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATGGCCAACCACACTGGATGG	0.488			NA											18	122					0	0	0.007413	0	0
OR2G6	391211	broad.mit.edu	37	1	248685555	248685555	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:248685555G>T	uc001ien.1	+	1	608	c.608G>T	c.(607-609)AGT>ATT	p.S203I		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	203	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTTGTGGCCAGTGTAGTCTTT	0.473			NA											35	86					1.99505e-19	3.55737e-19	0.002445	1	0
TAF3	83860	broad.mit.edu	37	10	8019213	8019213	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr10:8019213G>T	uc010qbd.1	+	4	2242	c.2242G>T	c.(2242-2244)GAA>TAA	p.E748*		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	748					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						GATAAAAGTGGAACCAGTCGC	0.448			NA											13	54					1.36491e-13	2.27965e-13	0.001855	1	0
ITGA8	8516	broad.mit.edu	37	10	15646286	15646286	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr10:15646286C>A	uc001ioc.1	-	20	2039	c.2039G>T	c.(2038-2040)GGG>GTG	p.G680V	ITGA8_uc010qcb.1_Missense_Mutation_p.G665V	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	680	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						TGCTCCTTCCCCTTCATTTCT	0.363			NA											14	67					1.5842e-08	2.42808e-08	0.001855	1	0
PTF1A	256297	broad.mit.edu	37	10	23482676	23482676	+	Silent	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr10:23482676A>G	uc001irp.2	+	2	828	c.828A>G	c.(826-828)CTA>CTG	p.L276L		NM_178161	NP_835455	Q7RTS3	PTF1A_HUMAN	pancreas specific transcription factor, 1a	276					endocrine pancreas development|exocrine pancreas development|regulation of transcription, DNA-dependent|tissue development|transcription, DNA-dependent	cytoplasm|transcription factor complex				pancreas(1)|skin(1)	2						TCCCTCCCCTAGCAGGACACT	0.507			NA											49	218					0	0	0.00361	0	0
GPR158	57512	broad.mit.edu	37	10	25887611	25887611	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr10:25887611T>A	uc001isj.2	+	11	3116	c.3056T>A	c.(3055-3057)GTG>GAG	p.V1019E	GPR158_uc001isk.2_Missense_Mutation_p.V394E	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	1019	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						CCTGGTCCTGTGCCTTCAGAA	0.473			NA											7	71					0	0	0.001984	0	0
RBP3	5949	broad.mit.edu	37	10	48389623	48389623	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr10:48389623C>T	uc001jez.2	-	1	1369	c.1255G>A	c.(1255-1257)GAG>AAG	p.E419K		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	419	4 X approximate tandem repeats.|2.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CGGATAGCCTCGTCCTCAGGC	0.637			NA											5	43					0	0	0.001168	0	0
HERC4	26091	broad.mit.edu	37	10	69714383	69714383	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr10:69714383T>A	uc001jng.3	-	20	2641	c.2330A>T	c.(2329-2331)GAA>GTA	p.E777V	HERC4_uc009xpq.2_Missense_Mutation_p.E310V|HERC4_uc001jnf.3_RNA|HERC4_uc001jnh.3_Missense_Mutation_p.E769V|HERC4_uc009xpr.2_Missense_Mutation_p.E777V|HERC4_uc001jni.3_Missense_Mutation_p.E513V	NM_022079	NP_071362	Q5GLZ8	HERC4_HUMAN	hect domain and RLD 4 isoform a	777	HECT.				cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3						CCTGGAATCTTCATAATACCT	0.378			NA											13	105					0	0	0.001855	0	0
RUFY2	55680	broad.mit.edu	37	10	70154089	70154089	+	Nonsense_Mutation	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr10:70154089G>C	uc001job.2	-	5	950	c.623C>G	c.(622-624)TCA>TGA	p.S208*	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joc.2_Nonsense_Mutation_p.S139*|RUFY2_uc010qiw.1_Nonsense_Mutation_p.S115*|RUFY2_uc001jod.1_Nonsense_Mutation_p.S173*|RUFY2_uc009xpv.1_Nonsense_Mutation_p.S56*|RUFY2_uc001joe.1_Nonsense_Mutation_p.S173*	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	222						nucleus	metal ion binding			ovary(1)	1						ACTTACTTGTGAGTCTAAATC	0.433			NA											8	73					0	0	0.006214	0	0
PIPSL	266971	broad.mit.edu	37	10	95720197	95720197	+	Silent	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr10:95720197T>A	uc009xuj.2	-	1	1476	c.957A>T	c.(955-957)CGA>CGT	p.R319R		NR_002319				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						TGCCACCCCGTCGAGCCTCTC	0.517			NA											7	66					0	0	0.00308	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98411383	98411383	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr10:98411383C>T	uc001kmq.2	-	5	866	c.738G>A	c.(736-738)CTG>CTA	p.L246L	PIK3AP1_uc001kmp.2_Silent_p.L68L	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	246	DBB.					cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		AATATATCTTCAGAGAAACGT	0.403			NA											4	34					0	0	0.000248	0	0
PPRC1	23082	broad.mit.edu	37	10	103898672	103898672	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr10:103898672G>A	uc001kum.2	+	4	565	c.526G>A	c.(526-528)GAA>AAA	p.E176K	PPRC1_uc001kun.2_Missense_Mutation_p.E56K|PPRC1_uc010qqj.1_Missense_Mutation_p.E176K|PPRC1_uc009xxa.2_5'Flank	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	176					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GACACCCCCAGAACGTGACCT	0.542			NA											7	59					0	0	0.00308	0	0
SORCS3	22986	broad.mit.edu	37	10	106960956	106960956	+	Missense_Mutation	SNP	C	C	A	rs145883987		TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr10:106960956C>A	uc001kyi.1	+	16	2433	c.2206C>A	c.(2206-2208)CAC>AAC	p.H736N	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	736	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GGGCCGAGACCACTCAGGATC	0.488	NSCLC(116;1497 1690 7108 13108 14106)		NA											9	103					7.48243e-07	1.08633e-06	0.006214	1	0
SMNDC1	10285	broad.mit.edu	37	10	112053973	112053973	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr10:112053973C>G	uc001kzc.3	-	6	854	c.652G>C	c.(652-654)GAT>CAT	p.D218H	SMNDC1_uc001kzb.2_Missense_Mutation_p.D139H	NM_005871	NP_005862	O75940	SPF30_HUMAN	survival motor neuron domain containing 1	218					apoptosis|induction of apoptosis|mRNA processing|RNA splicing, via transesterification reactions	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding|RNA binding			skin(1)	1		Breast(234;0.174)		Epithelial(162;6.86e-05)|all cancers(201;0.00149)|BRCA - Breast invasive adenocarcinoma(275;0.119)		ATAGGTTTATCAGCAATTCCA	0.388			NA											16	100					0	0	0.004007	0	0
PRLHR	2834	broad.mit.edu	37	10	120353949	120353949	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr10:120353949G>T	uc001ldp.1	-	2	947	c.808C>A	c.(808-810)CGC>AGC	p.R270S		NM_004248	NP_004239	P49683	PRLHR_HUMAN	G protein-coupled receptor 10	270	Cytoplasmic (Potential).				female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity				0		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		CGCCGAGCGCGGTCCCAGTCG	0.677			NA											7	28					8.12818e-05	0.000106968	0.001984	1	0
C10orf119	79892	broad.mit.edu	37	10	121595096	121595096	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr10:121595096G>C	uc001ler.2	-	14	1967	c.1669C>G	c.(1669-1671)CTT>GTT	p.L557V	C10orf119_uc001leq.1_Missense_Mutation_p.L382V|C10orf119_uc001les.1_Missense_Mutation_p.L382V	NM_024834	NP_079110	Q9BTE3	MCMBP_HUMAN	chromosome 10 open reading frame 119	557					cell division|DNA-dependent DNA replication|mitosis|S phase of mitotic cell cycle|sister chromatid cohesion	nucleus	chromatin binding				0		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.0044)		AATCTCAAAAGAGTTAGATAA	0.348			NA											10	77					0	0	0.006214	0	0
PRAP1	118471	broad.mit.edu	37	10	135165834	135165834	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr10:135165834C>G	uc001lmp.2	+	5	424	c.346C>G	c.(346-348)CCG>GCG	p.P116A	PRAP1_uc001lmr.2_Missense_Mutation_p.P107A|PRAP1_uc001lmq.1_Missense_Mutation_p.P88A	NM_145202	NP_660203	Q96NZ9	PRAP1_HUMAN	proline-rich acidic protein 1 isoform 1	116						extracellular region					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		all cancers(32;7.08e-06)|OV - Ovarian serous cystadenocarcinoma(35;7.88e-06)|Epithelial(32;9.48e-06)		GTACCACCCTCCGCCTGAGGA	0.632			NA											8	86					0	0	0.006214	0	0
OR2D3	120775	broad.mit.edu	37	11	6942680	6942680	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:6942680A>G	uc010rav.1	+	1	448	c.448A>G	c.(448-450)ACC>GCC	p.T150A		NM_001004684	NP_001004684	Q8NGH3	OR2D3_HUMAN	olfactory receptor, family 2, subfamily D,	150	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GTACTACTCTACCATCATGAC	0.512			NA											29	114					0	0	0.00632	0	0
OR10A6	390093	broad.mit.edu	37	11	7949730	7949730	+	Silent	SNP	T	T	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:7949730T>C	uc010rbh.1	-	1	480	c.480A>G	c.(478-480)ACA>ACG	p.T160T		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	160	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ATACCCATGATGTTTGAACAG	0.348			NA											6	50					0	0	0.001984	0	0
TUB	7275	broad.mit.edu	37	11	8060490	8060490	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:8060490G>A	uc001mfy.2	+	1	311	c.70G>A	c.(70-72)GGA>AGA	p.G24R	TUB_uc010rbk.1_Intron	NM_003320	NP_003311	P50607	TUB_HUMAN	tubby isoform a	Error:Variant_position_missing_in_P50607_after_alignment					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				ovary(1)	1		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		TTTGTTCCCAGGAGGCACTCC	0.552			NA											13	97					0	0	0.001855	0	0
CTR9	9646	broad.mit.edu	37	11	10781721	10781721	+	Silent	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:10781721G>A	uc001mja.2	+	6	743	c.594G>A	c.(592-594)GCG>GCA	p.A198A		NM_014633	NP_055448	Q6PD62	CTR9_HUMAN	SH2 domain binding protein 1	198	TPR 4.				histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				ovary(2)	2				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		ATTTTATAGCGGAAGTTCGTT	0.368			NA											5	65					0	0	0.000602	0	0
MUC15	143662	broad.mit.edu	37	11	26582728	26582728	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:26582728C>G	uc001mqx.2	-	4	1155	c.889G>C	c.(889-891)GGG>CGG	p.G297R	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Missense_Mutation_p.G324R|MUC15_uc001mqy.2_Missense_Mutation_p.G274R	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b	297	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						CTAGAATTCCCAAAACTCACA	0.378			NA											9	36					0	0	0.004482	0	0
RAG1	5896	broad.mit.edu	37	11	36596398	36596398	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:36596398C>A	uc001mwu.3	+	2	1668	c.1544C>A	c.(1543-1545)CCA>CAA	p.P515Q	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	515					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				GTACTTCTGCCAGGCTACCAC	0.493	Pancreas(43;321 1249 3212 48200)|Esophageal Squamous(38;49 1003 17530 24363)		NA							Familial_Hemophagocytic_Lymphohistiocytosis				15	104					2.48551e-13	4.1079e-13	0.00499	1	0
CKAP5	9793	broad.mit.edu	37	11	46786761	46786761	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:46786761C>G	uc001ndi.1	-	28	3567	c.3457G>C	c.(3457-3459)GAT>CAT	p.D1153H	CKAP5_uc009ylg.1_Missense_Mutation_p.D1039H|CKAP5_uc001ndj.1_Missense_Mutation_p.D1153H|CKAP5_uc001ndh.1_Missense_Mutation_p.D82H|SNORD67_uc001ndk.2_5'Flank	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	1153					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						TTGTCTTCATCCTCCTTTAAG	0.398	Ovarian(4;85 273 2202 4844 13323)		NA											6	146					0	0	0.001984	0	0
OR5I1	10798	broad.mit.edu	37	11	55703541	55703541	+	Silent	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:55703541T>A	uc010ris.1	-	1	336	c.336A>T	c.(334-336)ACA>ACT	p.T112T		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGAAGGATTCTGTATCTGCAA	0.438			NA											6	55					0	0	0.001168	0	0
LPXN	9404	broad.mit.edu	37	11	58318700	58318700	+	Silent	SNP	T	T	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:58318700T>G	uc001nmw.2	-	5	469	c.324A>C	c.(322-324)GCA>GCC	p.A108A	LPXN_uc009ymp.2_5'UTR|LPXN_uc010rkj.1_Silent_p.A113A|LPXN_uc010rkk.1_Silent_p.A88A|LPXN_uc010rkl.1_RNA	NM_004811	NP_004802	O60711	LPXN_HUMAN	leupaxin isoform 2	108					cell adhesion|protein complex assembly|signal transduction	cytoplasm	zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				CTGCTCTCACTGCAACCTGGC	0.483			NA											4	23					0	0	0.000248	0	0
MS4A5	64232	broad.mit.edu	37	11	60201330	60201330	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:60201330C>A	uc001npo.2	+	4	518	c.432C>A	c.(430-432)AAC>AAA	p.N144K		NM_023945	NP_076434	Q9H3V2	MS4A5_HUMAN	membrane-spanning 4-domains, subfamily A, member	144	Extracellular (Potential).					integral to membrane	receptor activity			large_intestine(1)|ovary(1)	2						TAGATCAAAACTACATTTGTG	0.368			NA											9	100					1.12685e-05	1.54393e-05	0.004482	1	0
CD5	921	broad.mit.edu	37	11	60885907	60885907	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:60885907C>T	uc009ynk.2	+	3	458	c.355C>T	c.(355-357)CAC>TAC	p.H119Y		NM_014207	NP_055022	P06127	CD5_HUMAN	CD5 molecule precursor	119	Extracellular (Potential).|SRCR 1.				cell proliferation|cell recognition	integral to plasma membrane	scavenger receptor activity			ovary(1)	1		all_lung(304;5.94e-05)|Lung NSC(402;7.26e-05)		BRCA - Breast invasive adenocarcinoma(625;0.000946)|Lung(977;0.0086)|LUSC - Lung squamous cell carcinoma(625;0.0528)		CAACTGCAGCCACAGCAGAAA	0.602			NA											6	136					0	0	0.001168	0	0
C11orf48	79081	broad.mit.edu	37	11	62435066	62435066	+	Nonsense_Mutation	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:62435066G>C	uc001nue.2	-	4	902	c.467C>G	c.(466-468)TCA>TGA	p.S156*	C11orf48_uc001nuf.2_Nonsense_Mutation_p.S156*|METTL12_uc001nuh.2_3'UTR|C11orf48_uc010rmd.1_Nonsense_Mutation_p.S156*	NM_024099	NP_077004	Q9BQE6	CK048_HUMAN	hypothetical protein LOC79081	182											0						GGAGCCTGTTGAGTCCCAGAA	0.507			NA											36	218					0	0	0.00623	0	0
SLC22A8	9376	broad.mit.edu	37	11	62782143	62782143	+	Silent	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:62782143C>G	uc001nwo.2	-	2	424	c.288G>C	c.(286-288)CTG>CTC	p.L96L	SLC22A8_uc001nwp.2_Silent_p.L96L|SLC22A8_uc009yom.2_Intron|SLC22A8_uc010rmm.1_Silent_p.L5L|SLC22A8_uc009yon.2_Silent_p.L96L	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	96	Extracellular (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						CCCAGCCATCCAGGCATGGCT	0.592			NA											23	138					0	0	0.002299	0	0
EFEMP2	30008	broad.mit.edu	37	11	65637376	65637376	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:65637376G>A	uc001ofy.3	-	7	873	c.679C>T	c.(679-681)CGC>TGC	p.R227C	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Missense_Mutation_p.R227C	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	227	EGF-like 4; calcium-binding (Potential).				blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		TGGTGGCAGCGACACAGGAAG	0.607			NA											17	97					0	0	0.00499	0	0
AIP	9049	broad.mit.edu	37	11	67250704	67250704	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:67250704C>T	uc001olv.2	+	1	200	c.75C>T	c.(73-75)CTC>CTT	p.L25L		NM_003977	NP_003968	O00170	AIP_HUMAN	aryl hydrocarbon receptor interacting protein	25					protein maturation by protein folding|protein targeting to mitochondrion	nucleus	signal transducer activity|transcription coactivator activity|transcription factor binding|unfolded protein binding				0						GAGGAGAGCTCCCGGACTTTC	0.617			NA							Familial_Isolated_Pituitary_Adenoma_				5	68					0	0	0.000602	0	0
TMEM126B	55863	broad.mit.edu	37	11	85345207	85345207	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:85345207G>C	uc001pao.2	+	4	443	c.191G>C	c.(190-192)AGA>ACA	p.R64T	TMEM126B_uc001pan.1_Missense_Mutation_p.R64T|TMEM126B_uc001pap.2_Missense_Mutation_p.R64T|TMEM126B_uc001paq.1_Missense_Mutation_p.R64T	NM_018480	NP_060950	Q8IUX1	T126B_HUMAN	transmembrane protein 126B	94						integral to membrane					0		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				TTCCTGTTCAGACGCTGCTTC	0.343			NA											8	102					0	0	0.004482	0	0
CCDC83	220047	broad.mit.edu	37	11	85593661	85593661	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:85593661G>A	uc001pbh.1	+	4	798	c.286G>A	c.(286-288)GAA>AAA	p.E96K	CCDC83_uc001pbg.1_Missense_Mutation_p.E96K|CCDC83_uc001pbi.1_RNA|CCDC83_uc001pbj.1_Missense_Mutation_p.E53K	NM_173556	NP_775827	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	96	Potential.									skin(1)	1		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				AGAGGATGTTGAAGAAGCGAT	0.403			NA											17	89					0	0	0.004007	0	0
MMP12	4321	broad.mit.edu	37	11	102742618	102742618	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:102742618G>T	uc001phk.2	-	3	460	c.415C>A	c.(415-417)CAA>AAA	p.Q139K		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	139					positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	CTCCATACTTGGAAAGCTTTC	0.408			NA											11	48					7.03913e-09	1.08677e-08	0.001368	1	0
MMP13	4322	broad.mit.edu	37	11	102824901	102824901	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:102824901C>T	uc001phl.2	-	4	649	c.621G>A	c.(619-621)TGG>TGA	p.W207*		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	207					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		AACTACTTGTCCAGGTTTCAT	0.388			NA											10	39					0	0	0.008291	0	0
RAB39	54734	broad.mit.edu	37	11	107832852	107832852	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:107832852A>T	uc001pjt.2	+	2	426	c.408A>T	c.(406-408)CAA>CAT	p.Q136H		NM_017516	NP_059986	Q14964	RB39A_HUMAN	RAB39, member RAS oncogene family	136					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0				BRCA - Breast invasive adenocarcinoma(274;3.04e-05)|Epithelial(105;8.56e-05)|all cancers(92;0.00179)		CACAACGTCAAGTTACAAGGG	0.378			NA											17	52					0	0	0.00499	0	0
BCL9L	283149	broad.mit.edu	37	11	118779239	118779239	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:118779239C>A	uc001pug.2	-	2	1117	c.152G>T	c.(151-153)GGG>GTG	p.G51V	BCL9L_uc009zal.2_Missense_Mutation_p.G46V	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	51					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		CCCGCCATTCCCTGTCTTGCC	0.642			NA											25	166					2.14196e-07	3.19025e-07	0.007291	1	0
MCAM	4162	broad.mit.edu	37	11	119183624	119183624	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:119183624T>A	uc001pwf.2	-	6	624	c.595A>T	c.(595-597)AGT>TGT	p.S199C	MCAM_uc001pwg.1_5'Flank	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	199	Ig-like V-type 2.|Extracellular (Potential).				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		TACAAACCACTCGACTCCACA	0.567			NA											15	71					0	0	0.004007	0	0
SRPR	6734	broad.mit.edu	37	11	126134327	126134327	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:126134327C>T	uc001qdh.2	-	12	1684	c.1633G>A	c.(1633-1635)GAT>AAT	p.D545N	SRPR_uc010sbm.1_Missense_Mutation_p.D517N	NM_003139	NP_003130	P08240	SRPR_HUMAN	signal recognition particle receptor	545					SRP-dependent cotranslational protein targeting to membrane	integral to membrane|signal recognition particle receptor complex	GTP binding|GTPase activity|receptor activity|signal recognition particle binding				0	all_hematologic(175;0.145)			BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0736)		AGCACCAAATCAGGTGTATTG	0.542			NA											9	60					0	0	0.006214	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1965188	1965188	+	Silent	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:1965188T>A	uc001qjp.2	-	22	2373	c.2142A>T	c.(2140-2142)CCA>CCT	p.P714P	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Silent_p.P578P|CACNA2D4_uc009zdr.1_5'Flank	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	714	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		ACTCCAGGTCTGGGTCCTTCC	0.592	Colon(2;101 179 21030 23310 28141)		NA											10	43					0	0	0.008291	0	0
ACRBP	84519	broad.mit.edu	37	12	6749349	6749349	+	Silent	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:6749349G>A	uc001qpu.1	-	8	1350	c.1302C>T	c.(1300-1302)TAC>TAT	p.Y434Y	LPAR5_uc010sff.1_5'Flank|ACRBP_uc001qpt.1_5'Flank|ACRBP_uc010sfg.1_Silent_p.Y401Y	NM_032489	NP_115878	Q8NEB7	ACRBP_HUMAN	proacrosin binding protein sp32 precursor	434						acrosomal vesicle|extracellular region				central_nervous_system(1)	1						GGAGCCCACCGTACAAATCCA	0.607			NA											7	54					0	0	0.004482	0	0
LAG3	3902	broad.mit.edu	37	12	6884556	6884556	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:6884556C>A	uc001qqt.3	+	5	1248	c.899C>A	c.(898-900)CCT>CAT	p.P300H	LAG3_uc001qqs.2_Missense_Mutation_p.P300H|LAG3_uc001qqu.2_Missense_Mutation_p.P130H	NM_002286	NP_002277	P18627	LAG3_HUMAN	lymphocyte-activation protein 3 precursor	300	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane	antigen binding|MHC class II protein binding				0						AAGTGGACTCCTCCTGGGGGA	0.642			NA											17	81					6.94344e-10	1.09606e-09	0.006122	1	0
C3AR1	719	broad.mit.edu	37	12	8212740	8212740	+	Silent	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:8212740G>T	uc001qtv.1	-	2	134	c.42C>A	c.(40-42)CTC>CTA	p.L14L		NM_004054	NP_004045	Q16581	C3AR_HUMAN	complement component 3a receptor 1	14	Extracellular (Potential).				blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)	1				Kidney(36;0.0893)		ATGGCTGTGAGAGTAGGTCAG	0.428			NA											12	115					1.5842e-08	2.42808e-08	0.001855	1	0
TAS2R19	259294	broad.mit.edu	37	12	11174720	11174720	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:11174720C>T	uc010shj.1	-	1	451	c.451G>A	c.(451-453)GAG>AAG	p.E151K	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176888	NP_795369	P59542	T2R19_HUMAN	taste receptor, type 2, member 19	151	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1						CACACTCTCTCATCCATGGTT	0.388			NA											13	115					0	0	0.001368	0	0
GRIN2B	2904	broad.mit.edu	37	12	13906333	13906333	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:13906333C>G	uc001rbt.2	-	3	1107	c.928G>C	c.(928-930)GAG>CAG	p.E310Q		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	310	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AAGCTGTGCTCAGACAGCATG	0.483			NA											11	92					0	0	0.000978	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			3	14					0.004672	0.00574248	0.004672	1	0
ALG10	84920	broad.mit.edu	37	12	34175705	34175705	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:34175705G>T	uc001rlm.2	+	1	490	c.171G>T	c.(169-171)CAG>CAT	p.Q57H		NM_032834	NP_116223	Q5BKT4	AG10A_HUMAN	asparagine-linked glycosylation 10 homolog	57	Extracellular (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			skin(1)	1	Lung NSC(5;3.82e-05)|Acute lymphoblastic leukemia(23;0.0142)|all_hematologic(23;0.0429)	Lung NSC(34;0.204)|all_lung(34;0.235)				CCCTTTCCCAGGTGGGGTCCC	0.642			NA											29	118					1.2476e-16	2.14601e-16	0.00632	1	0
DBX2	440097	broad.mit.edu	37	12	45417664	45417664	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:45417664C>A	uc001rok.1	-	3	685	c.513G>T	c.(511-513)ATG>ATT	p.M171I		NM_001004329	NP_001004329	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	171						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		GGAGAGGCAGCATGCTCTCTT	0.448			NA											6	68					3.59834e-05	4.82573e-05	0.001168	1	0
DIP2B	57609	broad.mit.edu	37	12	51108375	51108375	+	Silent	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:51108375A>G	uc001rwv.2	+	23	3003	c.2847A>G	c.(2845-2847)CAA>CAG	p.Q949Q	DIP2B_uc009zlt.2_Silent_p.Q379Q	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	949						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						GGCAAAAACAACCAGGTAATA	0.448			NA											15	51					0	0	0.004007	0	0
KRT84	3890	broad.mit.edu	37	12	52774887	52774887	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:52774887C>G	uc001sah.1	-	6	1228	c.1180G>C	c.(1180-1182)GAG>CAG	p.E394Q		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	keratin, hair, basic, 4	394	Rod.|Coil 2.					keratin filament	structural constituent of epidermis			skin(1)	1	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TGCTCAATCTCTGCCTTAAGC	0.552			NA											25	205					0	0	0.005443	0	0
KRT3	3850	broad.mit.edu	37	12	53189644	53189644	+	Silent	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:53189644G>C	uc001say.2	-	1	249	c.183C>G	c.(181-183)GGC>GGG	p.G61G		NM_057088	NP_476429	P12035	K2C3_HUMAN	keratin 3	61	Gly-rich.|Head.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity				0						TCTTGTTGCCGCCCAGGTTGT	0.612			NA											13	105					0	0	0.001855	0	0
NUP107	57122	broad.mit.edu	37	12	69084516	69084516	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:69084516A>T	uc001suf.2	+	4	408	c.293A>T	c.(292-294)AAT>ATT	p.N98I	NUP107_uc001sug.2_5'UTR|NUP107_uc010stj.1_Missense_Mutation_p.N69I	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	98					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			TTCTTTGGAAATCTCTCCATG	0.338			NA											17	83					0	0	0.004007	0	0
CCT2	10576	broad.mit.edu	37	12	69991418	69991418	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:69991418G>T	uc001svb.1	+	12	1197	c.1103G>T	c.(1102-1104)GGT>GTT	p.G368V	CCT2_uc009zrm.1_RNA|CCT2_uc009zrn.1_Missense_Mutation_p.G368V|CCT2_uc010stl.1_Missense_Mutation_p.G321V	NM_006431	NP_006422	P78371	TCPB_HUMAN	chaperonin containing TCP1, subunit 2	368					'de novo' posttranslational protein folding	nucleus	ATP binding|unfolded protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(2;7.7e-106)|Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.72e-18)|GBM - Glioblastoma multiforme(2;2.58e-10)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			TTAATTTTAGGTGAGGCTTGT	0.393			NA											16	82					3.41278e-10	5.41426e-10	0.00499	1	0
GLIPR1L2	144321	broad.mit.edu	37	12	75807464	75807464	+	Silent	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:75807464A>T	uc001sxr.1	+	3	575	c.567A>T	c.(565-567)ATA>ATT	p.I189I	GLIPR1L2_uc001sxp.1_Silent_p.I189I|GLIPR1L2_uc001sxq.1_Silent_p.I82I	NM_152436	NP_689649	Q4G1C9	GRPL2_HUMAN	GLI pathogenesis-related 1 like 2	189						integral to membrane				ovary(1)	1						CAATTTTCATATGCAACTATG	0.274			NA											27	174					0	0	0.005443	0	0
ANKS1B	56899	broad.mit.edu	37	12	99145221	99145221	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:99145221C>A	uc001tge.1	-	25	4001	c.3584G>T	c.(3583-3585)GGG>GTG	p.G1195V	ANKS1B_uc001tgf.1_Missense_Mutation_p.G711V|ANKS1B_uc001tgk.2_Missense_Mutation_p.G492V|ANKS1B_uc010svd.1_Missense_Mutation_p.G201V|ANKS1B_uc001tgd.1_Missense_Mutation_p.G361V|ANKS1B_uc009ztq.2_Missense_Mutation_p.G97V|ANKS1B_uc010sve.1_Missense_Mutation_p.G225V|ANKS1B_uc001tgh.3_Missense_Mutation_p.G201V|ANKS1B_uc001tgi.2_Missense_Mutation_p.G445V|ANKS1B_uc009ztr.2_Missense_Mutation_p.G385V|ANKS1B_uc001tgj.2_Missense_Mutation_p.G361V|ANKS1B_uc009ztp.2_Missense_Mutation_p.G226V|ANKS1B_uc010svf.1_Missense_Mutation_p.G225V|ANKS1B_uc001tgg.3_Missense_Mutation_p.G293V|ANKS1B_uc010svg.1_Missense_Mutation_p.G330V|ANKS1B_uc009zts.1_Missense_Mutation_p.G421V	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	1195	PID.					Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GGAGTGTCCCCCTTTTCTTGC	0.478			NA											12	101					7.03913e-09	1.08677e-08	0.001368	1	0
ANKS1B	56899	broad.mit.edu	37	12	100200327	100200327	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:100200327C>T	uc001tge.1	-	4	941	c.524G>A	c.(523-525)AGA>AAA	p.R175K	ANKS1B_uc001tgf.1_Intron|ANKS1B_uc009ztt.1_Missense_Mutation_p.R175K	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	175	ANK 5.					Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TTTTACCACTCTAAGCCGTCC	0.493			NA											8	58					0	0	0.00308	0	0
NUAK1	9891	broad.mit.edu	37	12	106461516	106461516	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:106461516C>A	uc001tlj.1	-	7	2430	c.1050G>T	c.(1048-1050)AAG>AAT	p.K350N		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	350							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						TGGCCAGGCCCTTCATTTTGG	0.567			NA											12	77					5.50884e-06	7.6304e-06	0.001368	1	0
SDSL	113675	broad.mit.edu	37	12	113873251	113873251	+	Silent	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:113873251G>C	uc001tvi.2	+	7	771	c.561G>C	c.(559-561)CTG>CTC	p.L187L	SDSL_uc009zwh.2_Silent_p.L187L	NM_138432	NP_612441	Q96GA7	SDSL_HUMAN	serine dehydratase-like	187					cellular amino acid metabolic process		L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|pyridoxal phosphate binding				0					Pyridoxal Phosphate(DB00114)	CTGGCCTGCTGGAGGTGGGCT	0.647			NA											10	34					0	0	0.006214	0	0
RBM19	9904	broad.mit.edu	37	12	114374889	114374889	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:114374889C>A	uc009zwi.2	-	16	2135	c.1991G>T	c.(1990-1992)AGC>ATC	p.S664I	RBM19_uc001tvn.3_Missense_Mutation_p.S664I|RBM19_uc001tvm.2_Missense_Mutation_p.S664I	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	664					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					TGGGGCTGTGCTGGAGAAGAC	0.527			NA											11	104					2.27111e-07	3.35891e-07	0.001368	1	0
UBC	7316	broad.mit.edu	37	12	125397469	125397469	+	Silent	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:125397469G>A	uc001ugs.3	-	2	1297	c.849C>T	c.(847-849)ACC>ACT	p.T283T	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Silent_p.T283T|UBC_uc001ugt.2_Silent_p.T283T|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_Silent_p.T131T	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	283	Ubiquitin-like 4.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		AGTCAGACAGGGTGCGCCCAT	0.527			NA											10	182					0	0	0.003163	0	0
AACS	65985	broad.mit.edu	37	12	125576036	125576036	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:125576036C>G	uc001uhc.2	+	5	743	c.537C>G	c.(535-537)ATC>ATG	p.I179M	AACS_uc009zyg.2_RNA|AACS_uc001uhd.2_Missense_Mutation_p.I179M|AACS_uc009zyh.2_RNA	NM_023928	NP_076417	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	179					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			ovary(1)|liver(1)|central_nervous_system(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		TTGGTGCCATCTGGAGCTCCA	0.587			NA											8	38					0	0	0.006214	0	0
RNF17	56163	broad.mit.edu	37	13	25367307	25367307	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr13:25367307A>G	uc001upr.2	+	10	1104	c.1063A>G	c.(1063-1065)AGT>GGT	p.S355G	RNF17_uc010tdd.1_Missense_Mutation_p.S214G|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.S355G|RNF17_uc001ups.2_Missense_Mutation_p.S294G|RNF17_uc001upq.1_Missense_Mutation_p.S355G	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	355					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TGTCCTAACCAGTGAAGCACC	0.393			NA											34	176					0	0	0.002836	0	0
ITM2B	9445	broad.mit.edu	37	13	48828025	48828025	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr13:48828025G>T	uc001vbz.3	+	2	422	c.199G>T	c.(199-201)GGT>TGT	p.G67C		NM_021999	NP_068839	Q9Y287	ITM2B_HUMAN	integral membrane protein 2B	67	Helical; Signal-anchor for type II membrane protein; (Potential).				nervous system development	Golgi membrane|integral to membrane|nucleus|plasma membrane	beta-amyloid binding				0		all_cancers(8;2.2e-31)|all_epithelial(8;6.77e-15)|all_lung(13;9.67e-07)|all_hematologic(8;9.72e-06)|Lung NSC(96;8.3e-05)|Breast(56;0.000141)|Acute lymphoblastic leukemia(8;0.00045)|Prostate(109;0.000669)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;1.97e-06)		TATGCTTGCAGGTGTTATTCT	0.378			NA											14	61					4.14922e-12	6.75181e-12	0.004007	1	0
NALCN	259232	broad.mit.edu	37	13	102029296	102029296	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr13:102029296G>T	uc001vox.1	-	5	676	c.487C>A	c.(487-489)CCA>ACA	p.P163T	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Missense_Mutation_p.P163T|NALCN_uc001vpa.2_Missense_Mutation_p.P163T	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	163	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTGGTCCTTGGCAGTTCAAAT	0.378			NA											13	54					2.27111e-07	3.35891e-07	0.001368	1	0
OR4L1	122742	broad.mit.edu	37	14	20528948	20528948	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr14:20528948C>G	uc001vwn.1	+	1	745	c.745C>G	c.(745-747)CTG>GTG	p.L249V		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	249	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TGTGGTCACTCTGTTCTTTGG	0.408			NA											24	114					0	0	0.00278	0	0
CHD8	57680	broad.mit.edu	37	14	21860803	21860803	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr14:21860803G>C	uc001was.1	-	34	5891	c.5797C>G	c.(5797-5799)CCA>GCA	p.P1933A	CHD8_uc001war.1_Missense_Mutation_p.P1829A|SNORD9_uc001wat.1_5'Flank	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	2212					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		GTGGGGACTGGAGAGTCACCA	0.552			NA											14	140					0	0	0.00245	0	0
CHD8	57680	broad.mit.edu	37	14	21863152	21863152	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr14:21863152G>A	uc001was.1	-	30	4566	c.4472C>T	c.(4471-4473)GCA>GTA	p.A1491V	CHD8_uc001war.1_Missense_Mutation_p.A1387V|SNORD9_uc001wat.1_5'Flank	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1770					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		CCCACGTTCTGCAGCCTCTAT	0.527			NA											18	63					0	0	0.008871	0	0
MYH7	4625	broad.mit.edu	37	14	23893993	23893993	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr14:23893993C>A	uc001wjx.2	-	22	2770	c.2664G>T	c.(2662-2664)CAG>CAT	p.Q888H		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	888	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GCACTTGGAGCTGCAGGTCAT	0.607			NA											7	48					0.00198382	0.00247684	0.001984	1	0
PRKD1	5587	broad.mit.edu	37	14	30066936	30066936	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr14:30066936C>A	uc001wqh.2	-	16	2376	c.2195G>T	c.(2194-2196)CGG>CTG	p.R732L		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	732	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TCCAATGATCCGGGCAAAACC	0.478			NA											11	55					2.31682e-05	3.14036e-05	0.003163	1	0
KLHDC2	23588	broad.mit.edu	37	14	50249171	50249171	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr14:50249171G>C	uc001wwx.2	+	11	1440	c.1040G>C	c.(1039-1041)AGA>ACA	p.R347T	SDCCAG1_uc010anj.1_Intron|KLHDC2_uc001wwy.2_Missense_Mutation_p.R347T|KLHDC2_uc010anp.2_3'UTR	NM_014315	NP_055130	Q9Y2U9	KLDC2_HUMAN	kelch domain containing 2	347	Kelch 6.					nucleus	protein binding			ovary(1)	1	all_epithelial(31;0.000959)|Breast(41;0.0117)					GTCCATCACAGAGCTGTAAGT	0.368			NA											7	88					0	0	0.001984	0	0
CGRRF1	10668	broad.mit.edu	37	14	55004779	55004779	+	Splice_Site	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr14:55004779A>T	uc001xay.2	+	6	770	c.679_splice	c.e6-2	p.Q227_splice	CGRRF1_uc001xaz.2_Splice_Site	NM_006568	NP_006559	Q99675	CGRF1_HUMAN	cell growth regulator with ring finger domain 1						cell cycle arrest|negative regulation of cell proliferation|response to stress		zinc ion binding			ovary(1)	1						TTTGATTTTCAGCAACTTTTC	0.303			NA											3	25					0	0	0.004672	0	0
C14orf149	112849	broad.mit.edu	37	14	59942718	59942718	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr14:59942718T>A	uc001xee.1	-	4	847	c.808A>T	c.(808-810)AGA>TGA	p.R270*		NM_144581	NP_653182	Q96EM0	PRCM_HUMAN	proline racemase-like	270							proline racemase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.14)	L-Proline(DB00172)	GTGGGACTTCTGTCAACCTGT	0.428			NA											9	74					0	0	0.006214	0	0
MAP3K9	4293	broad.mit.edu	37	14	71197272	71197272	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr14:71197272G>C	uc001xmm.2	-	12	3140	c.3140C>G	c.(3139-3141)CCT>CGT	p.P1047R	MAP3K9_uc010ttk.1_Missense_Mutation_p.P775R|MAP3K9_uc001xmk.2_Missense_Mutation_p.P780R|MAP3K9_uc001xml.2_Missense_Mutation_p.P1061R	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	1047					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(2)|lung(1)|central_nervous_system(1)|skin(1)	5				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		TGGAAGTCCAGGCCGCTCCTC	0.662	GBM(114;411 1587 13539 28235 50070)		NA											5	52					0	0	0.000602	0	0
KIAA1409	57578	broad.mit.edu	37	14	94041456	94041456	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr14:94041456T>C	uc001ybv.1	+	14	1675	c.1592T>C	c.(1591-1593)TTT>TCT	p.F531S	KIAA1409_uc001ybs.1_Missense_Mutation_p.F531S	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	708						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		ATAAGTATGTTTTCTGATGGA	0.368			NA											5	46					0	0	0.000602	0	0
KIAA1409	57578	broad.mit.edu	37	14	94088614	94088614	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr14:94088614C>G	uc001ybv.1	+	28	4653	c.4570C>G	c.(4570-4572)CTG>GTG	p.L1524V	KIAA1409_uc001ybs.1_Missense_Mutation_p.L1502V	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1679						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CGTCCTCAGCCTGAGCACAGC	0.527			NA											8	74					0	0	0.006214	0	0
PPP4R4	57718	broad.mit.edu	37	14	94708736	94708736	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr14:94708736C>T	uc001ycs.1	+	11	1411	c.1257C>T	c.(1255-1257)TGC>TGT	p.C419C		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	419	HEAT 3.					cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						TTGCTATTTGCTTTTATGAAG	0.323			NA											9	110					0	0	0.004482	0	0
GABRG3	2567	broad.mit.edu	37	15	27222202	27222202	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr15:27222202G>T	uc001zbg.1	+	2	273	c.107G>T	c.(106-108)TGG>TTG	p.W36L	GABRG3_uc001zbf.2_Missense_Mutation_p.W36L	NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	36	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		AACCAAAAGTGGGTCTTGGCT	0.423	NSCLC(114;800 1656 7410 37729 45293)		NA											18	66					3.41278e-10	5.41426e-10	0.00499	1	0
RYR3	6263	broad.mit.edu	37	15	33954863	33954863	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr15:33954863G>T	uc001zhi.2	+	35	5202	c.5132G>T	c.(5131-5133)CGA>CTA	p.R1711L	RYR3_uc010bar.2_Missense_Mutation_p.R1711L	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1711	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCCCACATCCGAGACCCTGTA	0.562			NA											9	55					0.00448238	0.00553089	0.004482	1	0
SPTBN5	51332	broad.mit.edu	37	15	42166580	42166580	+	Silent	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr15:42166580G>A	uc001zos.2	-	24	4827	c.4494C>T	c.(4492-4494)CTC>CTT	p.L1498L		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1533	Spectrin 12.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CTACCCAAGAGAGCTCCATGT	0.617			NA											18	56					0	0	0.00499	0	0
MAP1A	4130	broad.mit.edu	37	15	43820365	43820365	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr15:43820365C>A	uc001zrt.2	+	4	7161	c.6694C>A	c.(6694-6696)CAG>AAG	p.Q2232K		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2232						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CTCACTGCCCCAGCTCCCATC	0.637			NA											15	97					1.52009e-12	2.49279e-12	0.003163	1	0
DMXL2	23312	broad.mit.edu	37	15	51743895	51743895	+	Splice_Site	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr15:51743895C>G	uc002abf.2	-	41	8856	c.8631_splice	c.e41-1	p.R2877_splice	DMXL2_uc002abd.2_Splice_Site_p.R969_splice|DMXL2_uc010ufy.1_Splice_Site_p.R2878_splice|DMXL2_uc010bfa.2_Splice_Site_p.R2241_splice|DMXL2_uc002abc.2_5'Flank	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2							cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		GCAAACATTTCTTTTAAAGAA	0.318			NA											10	38					0	0	0.00245	0	0
HCN4	10021	broad.mit.edu	37	15	73617680	73617680	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr15:73617680C>A	uc002avp.2	-	5	2690	c.1696G>T	c.(1696-1698)GAG>TAG	p.E566*		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	566	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		ATGCTCTCCTCGTCGAACATC	0.667			NA											18	77					6.49762e-13	1.06831e-12	0.006122	1	0
ADAMTS17	170691	broad.mit.edu	37	15	100801810	100801810	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr15:100801810C>T	uc002bvv.1	-	6	984	c.905G>A	c.(904-906)CGG>CAG	p.R302Q	ADAMTS17_uc002bvx.1_Missense_Mutation_p.R59Q	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	302	Peptidase M12B.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		CTCCAGGGACCGCTCACCATG	0.547			NA											4	23					0	0	0.000248	0	0
WDR90	197335	broad.mit.edu	37	16	706348	706348	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr16:706348C>T	uc002cii.1	+	18	2067	c.2013C>T	c.(2011-2013)CTC>CTT	p.L671L	WDR90_uc002cig.1_3'UTR|WDR90_uc002cih.1_3'UTR|WDR90_uc002cij.1_Intron|WDR90_uc002cik.1_Silent_p.L198L|WDR90_uc002cil.1_5'Flank|WDR90_uc002cim.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	671	WD 5.									ovary(1)	1		Hepatocellular(780;0.0218)				CCGATGGCCTCCGTGTGCTGT	0.706			NA											3	10					0	0	0.004672	0	0
IFT140	9742	broad.mit.edu	37	16	1621515	1621515	+	Silent	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr16:1621515G>A	uc002cmb.2	-	14	1907	c.1545C>T	c.(1543-1545)CTC>CTT	p.L515L	IFT140_uc002clz.2_Silent_p.L166L	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	515										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				CCGAGAAAAGGAGGAGTTGTT	0.418			NA											6	35					0	0	0.001984	0	0
SEC14L5	9717	broad.mit.edu	37	16	5064946	5064946	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr16:5064946A>G	uc002cye.2	+	16	2246	c.2066A>G	c.(2065-2067)CAT>CGT	p.H689R		NM_014692	NP_055507	O43304	S14L5_HUMAN	SEC14-like 5	689	Ser-rich.					integral to membrane|intracellular	transporter activity				0						GGCCAGTCTCATAGCAGCTCC	0.642			NA											13	64					0	0	0.00245	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857858	9857858	+	Silent	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr16:9857858G>A	uc002czo.3	-	13	4091	c.3543C>T	c.(3541-3543)AAC>AAT	p.N1181N	GRIN2A_uc010uym.1_Silent_p.N1181N|GRIN2A_uc010uyn.1_Silent_p.N1024N|GRIN2A_uc002czr.3_Silent_p.N1181N	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1181	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TATACTGGTCGTTGTTGGAAA	0.552			NA											19	351					0	0	0.001523	0	0
GRIN2A	2903	broad.mit.edu	37	16	10032087	10032087	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr16:10032087G>T	uc002czo.3	-	3	1284	c.736C>A	c.(736-738)CTT>ATT	p.L246I	GRIN2A_uc010uym.1_Missense_Mutation_p.L246I|GRIN2A_uc010uyn.1_Missense_Mutation_p.L89I|GRIN2A_uc002czr.3_Missense_Mutation_p.L246I	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	246	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GTGAGGCCAAGGGAGCGGGCC	0.507			NA											12	78					3.07112e-06	4.28198e-06	0.000978	1	0
ZC3H7A	29066	broad.mit.edu	37	16	11861348	11861348	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr16:11861348C>T	uc002dbk.2	-	12	1645	c.1447G>A	c.(1447-1449)GAA>AAA	p.E483K	ZC3H7A_uc002dbj.2_5'Flank|ZC3H7A_uc002dbl.2_Missense_Mutation_p.E483K|ZC3H7A_uc002dbm.1_Missense_Mutation_p.E393K	NM_014153	NP_054872	Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	483						nucleus	nucleic acid binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						GATTTATCTTCAACATTCTTT	0.289			NA											10	72					0	0	0.006214	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25251807	25251807	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr16:25251807T>C	uc002dod.3	-	7	2641	c.2234A>G	c.(2233-2235)AAG>AGG	p.K745R	ZKSCAN2_uc010vcl.1_Missense_Mutation_p.K541R	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	745					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)		GTAGGGTCTCTTCCCCACAAA	0.478			NA											6	86					0	0	0.001168	0	0
IL21R	50615	broad.mit.edu	37	16	27441410	27441410	+	Silent	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr16:27441410C>A	uc002doq.1	+	2	251	c.18C>A	c.(16-18)GCC>GCA	p.A6A	IL21R_uc002dor.1_Silent_p.A6A|IL21R_uc002dos.1_Silent_p.A6A	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	6					natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						GTGGCTGGGCCGCCCCCTTGC	0.721			NA	T	BCL6	NHL								5	29					3.59834e-05	4.82573e-05	0.001168	1	0
RABEP2	79874	broad.mit.edu	37	16	28926016	28926016	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr16:28926016C>T	uc002drq.2	-	4	568	c.520G>A	c.(520-522)GAG>AAG	p.E174K	uc010vct.1_Intron|RABEP2_uc010vdf.1_Missense_Mutation_p.E103K|RABEP2_uc010byn.2_Missense_Mutation_p.E174K|RABEP2_uc002drr.2_Missense_Mutation_p.E174K	NM_024816	NP_079092	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	174	Potential.				endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			ovary(1)|breast(1)|skin(1)	3						ATCAGCTCCTCGGCCCTCAGC	0.677	Pancreas(66;639 1284 10093 31061 49099)		NA											13	127					0	0	0.00499	0	0
PHKG2	5261	broad.mit.edu	37	16	30762447	30762447	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr16:30762447G>T	uc002dzk.1	+	3	209	c.116G>T	c.(115-117)CGC>CTC	p.R39L	PHKG2_uc002dzi.1_Missense_Mutation_p.R39L|PHKG2_uc002dzj.1_5'UTR|PHKG2_uc002dzl.1_Missense_Mutation_p.R39L	NM_000294	NP_000285	P15735	PHKG2_HUMAN	phosphorylase kinase, gamma 2 (testis)	39	Protein kinase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			ovary(1)	1			Colorectal(24;0.198)			TCTGTGGTCCGCCGTTGTGTT	0.577			NA											7	55					0.000157383	0.000204987	0.00308	1	0
ITGAX	3687	broad.mit.edu	37	16	31373976	31373976	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr16:31373976G>T	uc002ebu.1	+	12	1328	c.1261G>T	c.(1261-1263)GTC>TTC	p.V421F	ITGAX_uc002ebt.2_Missense_Mutation_p.V421F|ITGAX_uc010vfk.1_Missense_Mutation_p.V71F	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	421	FG-GAP 4.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GCAGAGCCTGGTCCTGGGGGC	0.657			NA											5	20					3.59834e-05	4.82573e-05	0.001168	1	0
SHCBP1	79801	broad.mit.edu	37	16	46615701	46615701	+	Silent	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr16:46615701C>A	uc002eec.3	-	13	1999	c.1959G>T	c.(1957-1959)GGG>GGT	p.G653G		NM_024745	NP_079021	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	653								p.G653G(1)		ovary(1)|breast(1)	2		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				TCCCCACAATCCCAACAAACA	0.428			NA											18	101					1.9806e-07	2.97795e-07	0.002299	1	0
NFAT5	10725	broad.mit.edu	37	16	69725991	69725991	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr16:69725991G>A	uc002exm.1	+	12	3417	c.2209G>A	c.(2209-2211)GCA>ACA	p.A737T	NFAT5_uc002exi.2_Missense_Mutation_p.A661T|NFAT5_uc002exj.1_Missense_Mutation_p.A661T|NFAT5_uc002exk.1_Missense_Mutation_p.A661T|NFAT5_uc002exl.1_Missense_Mutation_p.A755T|NFAT5_uc002exn.1_Missense_Mutation_p.A754T|NFAT5_uc002exo.1_5'Flank	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	737					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						ACTGACTGAGGCATCACAACA	0.408			NA											15	60					0	0	0.003163	0	0
DPEP1	1800	broad.mit.edu	37	16	89704489	89704489	+	Silent	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr16:89704489G>A	uc010cin.2	+	11	1298	c.1095G>A	c.(1093-1095)GAG>GAA	p.E365E	DPEP1_uc002fnr.3_Silent_p.E365E|DPEP1_uc002fns.3_Silent_p.E365E	NM_001128141	NP_001121613	P16444	DPEP1_HUMAN	dipeptidase 1 precursor	365					proteolysis	anchored to membrane|apical plasma membrane|microvillus membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity|protein binding			large_intestine(1)	1		all_lung(18;0.0054)|all_hematologic(23;0.094)		BRCA - Breast invasive adenocarcinoma(80;0.0258)	Cilastatin(DB01597)	CTCCCGAGGAGGAGCCCATCC	0.687			NA											3	14					0	0	0.004672	0	0
DPEP1	1800	broad.mit.edu	37	16	89704574	89704574	+	Missense_Mutation	SNP	T	T	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr16:89704574T>G	uc010cin.2	+	11	1383	c.1180T>G	c.(1180-1182)TGG>GGG	p.W394G	DPEP1_uc002fnr.3_Missense_Mutation_p.W394G|DPEP1_uc002fns.3_Missense_Mutation_p.W394G	NM_001128141	NP_001121613	P16444	DPEP1_HUMAN	dipeptidase 1 precursor	394					proteolysis	anchored to membrane|apical plasma membrane|microvillus membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity|protein binding			large_intestine(1)	1		all_lung(18;0.0054)|all_hematologic(23;0.094)		BRCA - Breast invasive adenocarcinoma(80;0.0258)	Cilastatin(DB01597)	CCATCGCCACTGGGGGCTCCT	0.662			NA											6	33					0	0	0.001984	0	0
SPAG7	9552	broad.mit.edu	37	17	4863187	4863187	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr17:4863187C>T	uc002gae.2	-	6	475	c.442G>A	c.(442-444)GAG>AAG	p.E148K	SPAG7_uc002gad.2_Missense_Mutation_p.E97K|SPAG7_uc002gaf.2_Missense_Mutation_p.E148K	NM_004890	NP_004881	O75391	SPAG7_HUMAN	sperm associated antigen 7	148						nucleus	nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)	2						TGGGCTGCCTCCTCCTCTTGC	0.662			NA											11	60					0	0	0.000978	0	0
TP53	7157	broad.mit.edu	37	17	7577547	7577547	+	Missense_Mutation	SNP	C	C	A	rs121912656		TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr17:7577547C>A	uc002gim.2	-	7	928	c.734G>T	c.(733-735)GGC>GTC	p.G245V	TP53_uc002gig.1_Missense_Mutation_p.G245V|TP53_uc002gih.2_Missense_Mutation_p.G245V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113V|TP53_uc010cng.1_Missense_Mutation_p.G113V|TP53_uc002gii.1_Missense_Mutation_p.G113V|TP53_uc010cnh.1_Missense_Mutation_p.G245V|TP53_uc010cni.1_Missense_Mutation_p.G245V|TP53_uc002gij.2_Missense_Mutation_p.G245V|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152V|TP53_uc002gio.2_Missense_Mutation_p.G113V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.G245del(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.S241_G245delSCMGG(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGTTCATGCCGCCCATGCA	0.582	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	60					4.7546e-09	7.37663e-09	0.004007	1	0
MYH2	4620	broad.mit.edu	37	17	10448670	10448670	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr17:10448670C>A	uc010coi.2	-	5	626	c.498G>T	c.(496-498)ATG>ATT	p.M166I	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.M166I|MYH2_uc010coj.2_Missense_Mutation_p.M166I	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	166	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CACCAGTCAGCATGAACTGAT	0.522			NA											44	245					8.0703e-11	1.29657e-10	0.00361	1	0
DNAH9	1770	broad.mit.edu	37	17	11687720	11687720	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr17:11687720C>T	uc002gne.2	+	41	7993	c.7925C>T	c.(7924-7926)GCG>GTG	p.A2642V	DNAH9_uc010coo.2_Missense_Mutation_p.A1936V	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2642	AAA 3 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AACTTCCCGGCGTCCCTGCAG	0.547			NA											24	143					0	0	0.00333	0	0
SMCR7	125170	broad.mit.edu	37	17	18167939	18167939	+	Missense_Mutation	SNP	T	T	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr17:18167939T>G	uc002gst.2	+	4	1437	c.1226T>G	c.(1225-1227)ATC>AGC	p.I409S	SMCR7_uc002gsu.2_3'UTR|SMCR7_uc010vxq.1_Missense_Mutation_p.I420S	NM_139162	NP_631901	Q96C03	SMCR7_HUMAN	Smith-Magenis syndrome chromosome region,	409						integral to membrane	protein binding				0	all_neural(463;0.228)					GAGCTGCTCATCGGCAGCCTG	0.632			NA											11	57					0	0	0.008291	0	0
Unknown	0	broad.mit.edu	37	17	21731267	21731267	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr17:21731267C>G	uc002gyy.3	+	2	694	c.569C>G	c.(568-570)CCG>CGG	p.P190R						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;												NA						GGCATCCCCCCGATCAGCAGA	0.547			NA											28	98					0	0	0.005443	0	0
NEK8	284086	broad.mit.edu	37	17	27061971	27061971	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr17:27061971C>T	uc002hcp.2	+	3	435	c.435C>T	c.(433-435)ATC>ATT	p.I145I		NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	145	Protein kinase.					cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|pancreas(1)|liver(1)|skin(1)	6	Lung NSC(42;0.0158)					TCGTCAAGATCGGTGATTTCG	0.562	NSCLC(6;19 293 14866 25253 49845)		NA											29	107					0	0	0.001786	0	0
MYO18A	399687	broad.mit.edu	37	17	27445428	27445428	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr17:27445428C>G	uc002hdt.1	-	9	2018	c.1860G>C	c.(1858-1860)GAG>GAC	p.E620D	MYO18A_uc010wbc.1_Missense_Mutation_p.E162D|MYO18A_uc002hds.2_Missense_Mutation_p.E162D|MYO18A_uc010csa.1_Missense_Mutation_p.E620D|MYO18A_uc002hdu.1_Missense_Mutation_p.E620D|MYO18A_uc010wbd.1_Missense_Mutation_p.E289D	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	620	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			ACACATTGTTCTCTGCCAAGT	0.597	Esophageal Squamous(182;472 2015 7001 15270 22562)		NA											4	21					0	0	0.000602	0	0
AMAC1	146861	broad.mit.edu	37	17	33520323	33520323	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr17:33520323C>T	uc002hjd.2	-	1	1090	c.1004G>A	c.(1003-1005)AGG>AAG	p.R335K		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	335						integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		CTCCTCCACCCTCCCTGTCCT	0.557			NA											4	73					0	0	0.000248	0	0
LASP1	3927	broad.mit.edu	37	17	37070638	37070638	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr17:37070638G>C	uc002hra.2	+	5	749	c.418G>C	c.(418-420)GAG>CAG	p.E140Q	LASP1_uc010cvq.2_Missense_Mutation_p.W17C|LASP1_uc010wdz.1_Missense_Mutation_p.E84Q	NM_006148	NP_006139	Q14847	LASP1_HUMAN	LIM and SH3 protein 1	140						cortical actin cytoskeleton	ion transmembrane transporter activity|SH3/SH2 adaptor activity|zinc ion binding			lung(1)	1						CGAGGGCATGGAGCCAGAGCG	0.632			NA	T	MLL	AML								3	41					0	0	0.004672	0	0
FKBP10	60681	broad.mit.edu	37	17	39974664	39974664	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr17:39974664C>T	uc002hxv.2	+	4	937	c.612C>T	c.(610-612)TAC>TAT	p.Y204Y	FKBP10_uc002hxw.1_5'Flank	NM_021939	NP_068758	Q96AY3	FKB10_HUMAN	FK506 binding protein 10 precursor	204	PPIase FKBP-type 2.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		ATGACACCTACGTCGGCTCTG	0.592			NA											7	49					0	0	0.004482	0	0
ATP6V0A1	535	broad.mit.edu	37	17	40666456	40666456	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr17:40666456C>T	uc002hzr.2	+	21	2565	c.2398C>T	c.(2398-2400)CTC>TTC	p.L800F	ATP6V0A1_uc002hzq.2_Missense_Mutation_p.L794F|ATP6V0A1_uc002hzs.2_Missense_Mutation_p.L801F|ATP6V0A1_uc010wgj.1_Missense_Mutation_p.L757F|ATP6V0A1_uc010wgk.1_Missense_Mutation_p.L751F|ATP6V0A1_uc010cyg.2_Missense_Mutation_p.L446F|ATP6V0A1_uc010wgl.1_Missense_Mutation_p.L659F|ATP6V0A1_uc002hzt.2_Missense_Mutation_p.L84F	NM_001130021	NP_001123493	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	800	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		CTCGGCCTTTCTCCACGCACT	0.612			NA											30	143					0	0	0.002096	0	0
KIAA1267	284058	broad.mit.edu	37	17	44249069	44249069	+	Silent	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr17:44249069T>A	uc002ikb.2	-	1	526	c.441A>T	c.(439-441)ACA>ACT	p.T147T	KIAA1267_uc002ikc.2_Silent_p.T147T|KIAA1267_uc002ikd.2_Silent_p.T147T|KIAA1267_uc010dav.2_Silent_p.T147T	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	147						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				GTGGCAGAGCTGTCTGACCAC	0.438			NA											49	476					0	0	0.00361	0	0
RAD51C	5889	broad.mit.edu	37	17	56780677	56780677	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr17:56780677C>T	uc002iwu.2	+	4	734	c.692C>T	c.(691-693)TCA>TTA	p.S231L	RAD51C_uc010woa.1_Missense_Mutation_p.S231L|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_RNA|RAD51C_uc002iww.2_RNA|RAD51C_uc010wob.1_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	231					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GATTTCCTTTCAGAACACTCA	0.333			NA						Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				10	118					0	0	0.001855	0	0
PITPNC1	26207	broad.mit.edu	37	17	65688837	65688837	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr17:65688837A>T	uc002jgc.2	+	9	1179	c.832A>T	c.(832-834)ACC>TCC	p.T278S	PITPNC1_uc002jgb.2_3'UTR	NM_012417	NP_036549	Q9UKF7	PITC1_HUMAN	phosphatidylinositol transfer protein,	278					signal transduction	cytoplasm	lipid binding|phosphatidylinositol transporter activity|protein binding			skin(1)	1	all_cancers(12;3.03e-10)		BRCA - Breast invasive adenocarcinoma(8;2.08e-08)|Colorectal(3;0.198)			TGCTCCATCCACCCCTCTCTC	0.547			NA											27	137					0	0	0.004656	0	0
ABCA8	10351	broad.mit.edu	37	17	66883272	66883272	+	Splice_Site	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr17:66883272C>A	uc002jhp.2	-	24	3375	c.3196_splice	c.e24-1	p.I1066_splice	ABCA8_uc002jhq.2_Splice_Site_p.I1106_splice|ABCA8_uc010wqq.1_Splice_Site_p.I1106_splice|ABCA8_uc010wqr.1_Intron	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8							integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					CACATGGGATCTAAAATCAAC	0.353			NA											11	22					3.07112e-06	4.28198e-06	0.000978	1	0
CD300LB	124599	broad.mit.edu	37	17	72522083	72522083	+	Silent	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr17:72522083G>A	uc002jkx.2	-	2	298	c.285C>T	c.(283-285)TGC>TGT	p.C95C	CD300LB_uc010wqz.1_Silent_p.C95C	NM_174892	NP_777552	A8K4G0	CLM7_HUMAN	CD300 molecule-like family member b	58	Ig-like V-type.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)	1						TGAGGATCTTGCATGTATCCC	0.547			NA											34	159					0	0	0.003755	0	0
LLGL2	3993	broad.mit.edu	37	17	73569271	73569271	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr17:73569271C>T	uc002joh.2	+	20	2791	c.2637C>T	c.(2635-2637)CCC>CCT	p.P879P	LLGL2_uc002joi.2_Silent_p.P879P|LLGL2_uc010dgg.1_Silent_p.P879P|LLGL2_uc002joj.2_Silent_p.P868P|LLGL2_uc010wsd.1_Silent_p.P506P	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	879	WD 13.				cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			TCTCGCTGCCCCTGCTCAAGC	0.642			NA											11	47					0	0	0.001368	0	0
DSG3	1830	broad.mit.edu	37	18	29039937	29039937	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr18:29039937G>T	uc002kws.2	+	6	756	c.647G>T	c.(646-648)GGG>GTG	p.G216V		NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	216	Extracellular (Potential).|Cadherin 2.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGAAACACTGGGGAAGTCCGT	0.433			NA											8	43					1.12685e-05	1.54393e-05	0.004482	1	0
ASXL3	80816	broad.mit.edu	37	18	31322919	31322919	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr18:31322919G>T	uc010dmg.1	+	12	3162	c.3107G>T	c.(3106-3108)CGA>CTA	p.R1036L	ASXL3_uc002kxq.2_Missense_Mutation_p.R743L	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1036					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						CCTGAGTCTCGAGCATCCACT	0.507			NA											8	17					1.12685e-05	1.54393e-05	0.004482	1	0
MOCOS	55034	broad.mit.edu	37	18	33800118	33800118	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr18:33800118G>T	uc002kzq.3	+	9	1921	c.1898G>T	c.(1897-1899)CGG>CTG	p.R633L		NM_017947	NP_060417	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	633					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	CAGGAACCCCGGCTCTGCCTG	0.527			NA											11	68					3.07112e-06	4.28198e-06	0.000978	1	0
SMAD2	4087	broad.mit.edu	37	18	45371730	45371730	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr18:45371730C>A	uc002lcy.2	-	10	1509	c.1261G>T	c.(1261-1263)GGG>TGG	p.G421W	SMAD2_uc002lcz.2_Missense_Mutation_p.G421W|SMAD2_uc010xdc.1_Missense_Mutation_p.G391W|SMAD2_uc010xdd.1_Missense_Mutation_p.G391W	NM_005901	NP_005892	Q15796	SMAD2_HUMAN	Sma- and Mad-related protein 2 isoform 1	421	MH2.				anterior/posterior pattern formation|cell fate commitment|common-partner SMAD protein phosphorylation|intracellular signal transduction|mesoderm formation|negative regulation of transcription, DNA-dependent|palate development|paraxial mesoderm morphogenesis|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|regulation of binding|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	activin responsive factor complex|cytosol	activating transcription factor binding|co-SMAD binding|double-stranded DNA binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			large_intestine(3)|lung(1)|central_nervous_system(1)	5						GCTCCCCACCCTTTCACAAAA	0.388			NA											16	95					1.99824e-07	2.98322e-07	0.00499	1	0
LMAN1	3998	broad.mit.edu	37	18	57013159	57013159	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr18:57013159C>A	uc002lhz.2	-	8	979	c.947G>T	c.(946-948)GGG>GTG	p.G316V		NM_005570	NP_005561	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1 precursor	316	Lumenal (Potential).				blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			skin(1)	1		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)	ACCAGGCTGCCCTTGGAGGTC	0.488			NA											22	70					6.44725e-10	1.02028e-09	0.002299	1	0
C3	718	broad.mit.edu	37	19	6710817	6710817	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:6710817C>G	uc002mfm.2	-	13	1581	c.1519G>C	c.(1519-1521)GTG>CTG	p.V507L		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	507					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GGCTCTCGCACCTGGCGTCCC	0.652			NA											15	46					0	0	0.007413	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8657674	8657674	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:8657674C>T	uc002mkj.1	-	13	1834	c.1560G>A	c.(1558-1560)CTG>CTA	p.L520L	ADAMTS10_uc002mki.1_5'Flank|ADAMTS10_uc002mkk.1_Silent_p.L152L	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	520	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						GCGTCTGGCACAGCGTGCCCT	0.716			NA											6	33					0	0	0.001984	0	0
MUC16	94025	broad.mit.edu	37	19	9073651	9073651	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:9073651G>T	uc002mkp.2	-	3	13999	c.13795C>A	c.(13795-13797)CTG>ATG	p.L4599M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4601	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCAGCAGTCAGGGAGGATGTT	0.502			NA											9	56					1.76689e-08	2.69504e-08	0.006214	1	0
MUC16	94025	broad.mit.edu	37	19	9083145	9083145	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:9083145C>T	uc002mkp.2	-	1	8874	c.8670G>A	c.(8668-8670)TTG>TTA	p.L2890L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2891	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACTCAAATGTCAAGGTAGACT	0.517			NA											7	40					0	0	0.00308	0	0
ZNF559	84527	broad.mit.edu	37	19	9452607	9452607	+	Silent	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:9452607A>T	uc002mlg.2	+	7	1127	c.480A>T	c.(478-480)CTA>CTT	p.L160L	ZNF559_uc002mlf.2_5'UTR|ZNF559_uc010dwl.1_5'UTR|ZNF559_uc010xkn.1_Silent_p.L152L|ZNF559_uc010dwm.1_3'UTR|ZNF559_uc002mle.3_Silent_p.L224L|ZNF559_uc010dwk.1_5'UTR|ZNF559_uc002mld.2_3'UTR|ZNF559_uc010dwo.1_Intron|ZNF177_uc002mli.2_Intron|ZNF177_uc002mlj.2_Intron	NM_032497	NP_115886	Q9BR84	ZN559_HUMAN	zinc finger protein 559	160	C2H2-type 3; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GCCAACATCTACATCTTGTTT	0.373			NA											27	134					0	0	0.005443	0	0
ZNF121	7675	broad.mit.edu	37	19	9677452	9677452	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:9677452C>A	uc010xkp.1	-	4	569	c.337G>T	c.(337-339)GAA>TAA	p.E113*	ZNF121_uc010dwt.2_Nonsense_Mutation_p.E113*|ZNF121_uc010xkq.1_Nonsense_Mutation_p.E113*	NM_001008727	NP_001008727	P58317	ZN121_HUMAN	zinc finger protein 121	113					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TAGAGTGTTTCTCCATTGTGA	0.413			NA											12	56					4.3838e-07	6.43839e-07	0.001855	1	0
ICAM1	3383	broad.mit.edu	37	19	10395694	10395694	+	Silent	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:10395694G>C	uc002mnq.2	+	6	1735	c.1416G>C	c.(1414-1416)GTG>GTC	p.V472V	ICAM1_uc010xle.1_Silent_p.V250V|ICAM4_uc002mnr.1_5'Flank|ICAM4_uc002mns.1_5'Flank|ICAM4_uc002mnt.1_5'Flank	NM_000201	NP_000192	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1 precursor	472	Extracellular (Potential).				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	AGGTGACCGTGAATGTGCTCT	0.627			NA											4	42					0	0	0.000602	0	0
SFRS14	10147	broad.mit.edu	37	19	19121141	19121141	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:19121141C>G	uc002nkx.2	-	5	2007	c.1861G>C	c.(1861-1863)GAT>CAT	p.D621H	SFRS14_uc002nkz.1_Missense_Mutation_p.D635H|SFRS14_uc002nla.1_Missense_Mutation_p.D621H|SFRS14_uc002nlb.2_Missense_Mutation_p.D621H|SFRS14_uc010xqk.1_Missense_Mutation_p.D390H	NM_014884	NP_055699	Q8IX01	SUGP2_HUMAN	splicing factor, arginine/serine-rich 14	621	SURP motif 1.				mRNA processing|RNA splicing	nucleus	RNA binding				0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)			CTATTTTCATCAGACAAAAAC	0.438			NA											23	207					0	0	0.00278	0	0
SLC25A42	284439	broad.mit.edu	37	19	19216420	19216420	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:19216420C>T	uc002nlf.1	+	5	415	c.264C>T	c.(262-264)AGC>AGT	p.S88S	SLC25A42_uc010xqn.1_Silent_p.S140S	NM_178526	NP_848621	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	88	Solcar 1.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			GATTTCTCAGCTTGTGGCGCG	0.622			NA											7	16					0	0	0.001984	0	0
NCAN	1463	broad.mit.edu	37	19	19338336	19338336	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:19338336T>A	uc002nlz.2	+	8	2006	c.1907T>A	c.(1906-1908)CTG>CAG	p.L636Q	NCAN_uc010ecc.1_Missense_Mutation_p.L200Q	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	636					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			ATGGCCATGCTGCGTGGTCCC	0.637			NA											14	56					0	0	0.003163	0	0
KIAA0892	23383	broad.mit.edu	37	19	19454666	19454666	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:19454666C>T	uc002nmk.3	+	10	1033	c.994C>T	c.(994-996)CTG>TTG	p.L332L	KIAA0892_uc002nml.3_5'Flank|KIAA0892_uc010ecd.2_5'Flank	NM_015329	NP_056144	Q9Y6X3	SCC4_HUMAN	hypothetical protein LOC23383 precursor	332					cell division|maintenance of mitotic sister chromatid cohesion	chromatin|nucleoplasm|SMC loading complex	protein N-terminus binding				0						CAGCCCCATCCTGTCATCCTT	0.637			NA											18	111					0	0	0.006122	0	0
LOC284441	284441	broad.mit.edu	37	19	20370104	20370104	+	Silent	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:20370104A>G	uc002nov.2	+	1	1648	c.897A>G	c.(895-897)GTA>GTG	p.V299V		NR_003128				SubName: Full=cDNA FLJ51655, highly similar to Actin-like protein 2;												0						AGCACATGGTATTCTTGGGTG	0.413			NA											10	40					0	0	0.000978	0	0
ZNF737	100129842	broad.mit.edu	37	19	20727531	20727531	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:20727531G>A	uc002npa.2	-	4	1658	c.1478C>T	c.(1477-1479)TCC>TTC	p.S493F		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	493					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						AAGGATAAAGGAGCGCTTAAA	0.423			NA											6	34					0	0	0.001168	0	0
ZNF676	163223	broad.mit.edu	37	19	22363099	22363099	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:22363099C>A	uc002nqs.1	-	3	1738	c.1420G>T	c.(1420-1422)GAG>TAG	p.E474*		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	474					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TAAGGTTTCTCTGCAGCATGA	0.393			NA											28	107					1.08312e-15	1.8332e-15	0.001786	1	0
ZNF492	57615	broad.mit.edu	37	19	22847414	22847415	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:22847414_22847415GG>TT	uc002nqw.3	+	4	1187_1188	c.943_944GG>TT	c.(943-945)GGT>TTT	p.G315F		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	315	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				TGAAGAATGTGGTAAGGCCTTT	0.381			NA											11	52					0	0	0.004672	0	0
ZNF536	9745	broad.mit.edu	37	19	30936456	30936456	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:30936456G>T	uc002nsu.1	+	2	2125	c.1987G>T	c.(1987-1989)GGG>TGG	p.G663W	ZNF536_uc010edd.1_Missense_Mutation_p.G663W	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	663					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CGAGGAGGATGGGCTGCACGT	0.697			NA											7	51					0.00198382	0.00247684	0.001984	1	0
ZNF536	9745	broad.mit.edu	37	19	31039052	31039052	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:31039052C>A	uc002nsu.1	+	4	2664	c.2526C>A	c.(2524-2526)TTC>TTA	p.F842L	ZNF536_uc010edd.1_Missense_Mutation_p.F842L	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	842					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GGGGGGCCTTCAAGGGTCTCC	0.587			NA											25	76					6.36457e-07	9.28289e-07	0.003954	1	0
DPY19L3	147991	broad.mit.edu	37	19	32949374	32949374	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:32949374C>T	uc002ntg.2	+	12	1457	c.1281C>T	c.(1279-1281)ATC>ATT	p.I427I	DPY19L3_uc002nth.1_Silent_p.I427I|DPY19L3_uc002nti.1_RNA	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	427	Helical; (Potential).					integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					TTCTGTCCATCACAGTGATTG	0.373			NA											12	203					0	0	0.001368	0	0
ZNF585A	199704	broad.mit.edu	37	19	37643728	37643728	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:37643728T>A	uc002ofo.1	-	5	1304	c.1073A>T	c.(1072-1074)GAG>GTG	p.E358V	ZNF585A_uc002ofm.1_Missense_Mutation_p.E303V|ZNF585A_uc002ofn.1_Missense_Mutation_p.E303V	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	358	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTTCCCACACTCAGTACATAT	0.408			NA											28	131					0	0	0.00632	0	0
CYP2B6	1555	broad.mit.edu	37	19	41515256	41515256	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:41515256G>A	uc002opr.1	+	5	785	c.778G>A	c.(778-780)GCC>ACC	p.A260T	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Intron	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	260					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	GGACCCCAGCGCCCCCAAGGA	0.448			NA											20	58					0	0	0.008871	0	0
ATP1A3	478	broad.mit.edu	37	19	42492226	42492226	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:42492226C>T	uc002osg.2	-	4	373	c.219G>A	c.(217-219)CCG>CCA	p.P73P	ATP1A3_uc010xwf.1_Silent_p.P84P|ATP1A3_uc010xwg.1_Silent_p.P43P|ATP1A3_uc010xwh.1_Silent_p.P86P|ATP1A3_uc002osh.2_Silent_p.P73P	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	73	Interaction with phosphoinositide-3 kinase (By similarity).|Cytoplasmic (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						GGGTGGTAGGCGGTGGCGTGA	0.622			NA											10	86					0	0	0.006214	0	0
TMEM145	284339	broad.mit.edu	37	19	42819386	42819386	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:42819386C>G	uc002otk.1	+	7	604	c.552C>G	c.(550-552)ATC>ATG	p.I184M		NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	184	Helical; (Potential).					integral to membrane					0		Prostate(69;0.00682)				tcatcctcatcttcttcctct	0.453			NA											4	63					0	0	0.000248	0	0
TMEM145	284339	broad.mit.edu	37	19	42819403	42819403	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:42819403A>T	uc002otk.1	+	7	621	c.569A>T	c.(568-570)TAC>TTC	p.Y190F		NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	190	Helical; (Potential).					integral to membrane					0		Prostate(69;0.00682)				ctctcttGTTACTTTGGATGT	0.453			NA											8	78					0	0	0.00308	0	0
ZNF221	7638	broad.mit.edu	37	19	44470668	44470668	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:44470668C>T	uc002oxx.2	+	6	1342	c.1014C>T	c.(1012-1014)TTC>TTT	p.F338F	ZNF221_uc010ejb.1_Silent_p.F338F|ZNF221_uc010xws.1_Silent_p.F338F	NM_013359	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	338	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Prostate(69;0.0352)				AAAAAGCATTCAGATGTGATA	0.413			NA											12	160					0	0	0.001368	0	0
ZNF233	353355	broad.mit.edu	37	19	44778728	44778728	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:44778728C>A	uc002oyz.1	+	5	2042	c.1915C>A	c.(1915-1917)CAG>AAG	p.Q639K	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Missense_Mutation_p.Q454K	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	639	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				TCAAGCCCATCAGAGAGTCCA	0.428			NA											21	58					4.35082e-09	6.76675e-09	0.001523	1	0
LIG1	3978	broad.mit.edu	37	19	48665538	48665538	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:48665538C>A	uc002pia.1	-	3	208	c.88G>T	c.(88-90)GAG>TAG	p.E30*	LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Nonsense_Mutation_p.E30*|LIG1_uc010xzg.1_Intron|LIG1_uc010xzh.1_RNA	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	30					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	GGCTCCGTCTCTCTGCTGCTA	0.378			NA						NER					16	209					3.41278e-10	5.41426e-10	0.00499	1	0
ZNF610	162963	broad.mit.edu	37	19	52868949	52868949	+	Splice_Site	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:52868949A>T	uc002pyx.3	+	6	726	c.320_splice	c.e6-2	p.G107_splice	ZNF610_uc002pyy.3_Splice_Site_p.G107_splice|ZNF610_uc002pyz.3_Splice_Site_p.G64_splice|ZNF610_uc002pza.2_Splice_Site_p.G107_splice	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		CTTCTTTTCTAGGGAGGAGCT	0.448			NA											20	118					0	0	0.001882	0	0
ZNF528	84436	broad.mit.edu	37	19	52918883	52918883	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:52918883C>T	uc002pzh.2	+	7	1204	c.778C>T	c.(778-780)CAA>TAA	p.Q260*	ZNF528_uc002pzi.2_Nonsense_Mutation_p.Q27*	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	260	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		TTCACAACATCAAAGAATTCA	0.388			NA											8	99					0	0	0.00308	0	0
VN1R2	317701	broad.mit.edu	37	19	53762367	53762367	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:53762367G>A	uc002qbi.2	+	1	823	c.739G>A	c.(739-741)GGA>AGA	p.G247R		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	247	Extracellular (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0				GBM - Glioblastoma multiforme(134;0.00301)		AGGAGATTTGGGATATTGTTC	0.438			NA											15	113					0	0	0.004007	0	0
LILRA2	11027	broad.mit.edu	37	19	55086935	55086935	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:55086935G>T	uc002qgg.3	+	5	957	c.868G>T	c.(868-870)GGG>TGG	p.G290W	LILRA2_uc010ern.2_Missense_Mutation_p.G290W|LILRA2_uc002qgf.2_Missense_Mutation_p.G290W|LILRA2_uc010yfe.1_Missense_Mutation_p.G290W|LILRA2_uc010yff.1_Missense_Mutation_p.G278W|LILRA2_uc010ero.2_Missense_Mutation_p.G278W|LILRA2_uc010yfg.1_Intron	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	290	Ig-like C2-type 3.|Extracellular (Potential).				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CCCCTCCCACGGGGGCCAGTA	0.657			NA											10	59					1.76689e-08	2.69504e-08	0.006214	1	0
NLRP7	199713	broad.mit.edu	37	19	55447692	55447692	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:55447692C>T	uc002qih.3	-	6	2313	c.2237G>A	c.(2236-2238)CGC>CAC	p.R746H	NLRP7_uc002qig.3_Missense_Mutation_p.R718H|NLRP7_uc002qii.3_Missense_Mutation_p.R746H|NLRP7_uc010esk.2_Missense_Mutation_p.R746H|NLRP7_uc010esl.2_Missense_Mutation_p.R774H	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	746							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		CATCATCGTGCGTTCCCACTC	0.572			NA											6	78					0	0	0.001984	0	0
ZNF606	80095	broad.mit.edu	37	19	58490898	58490898	+	Missense_Mutation	SNP	C	C	T	rs142065196	byFrequency	TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:58490898C>T	uc002qqw.2	-	7	1768	c.1150G>A	c.(1150-1152)GAC>AAC	p.D384N	ZNF606_uc010yhp.1_Missense_Mutation_p.D294N	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	384					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		AGGAAAGAGTCATACCCAAAG	0.363			NA											19	96					0	0	0.007413	0	0
ZNF274	10782	broad.mit.edu	37	19	58723923	58723923	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr19:58723923G>A	uc002qrq.1	+	10	1835	c.1376G>A	c.(1375-1377)AGT>AAT	p.S459N	ZNF274_uc002qrr.1_Missense_Mutation_p.S427N|ZNF274_uc002qrs.1_Missense_Mutation_p.S354N|ZNF274_uc010eum.1_Missense_Mutation_p.S218N	NM_133502	NP_598009	Q96GC6	ZN274_HUMAN	zinc finger protein 274 isoform c	459					viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		CAAGTTAAAAGTATGAAACAT	0.428			NA											11	135					0	0	0.008291	0	0
PXDN	7837	broad.mit.edu	37	2	1652789	1652789	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:1652789A>T	uc002qxa.2	-	17	2827	c.2763T>A	c.(2761-2763)CAT>CAA	p.H921Q		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	921					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TGCGGGCCTCATGCTCCGTGC	0.672			NA											9	38					0	0	0.000978	0	0
PXDN	7837	broad.mit.edu	37	2	1653262	1653262	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:1653262C>A	uc002qxa.2	-	17	2354	c.2290G>T	c.(2290-2292)GAG>TAG	p.E764*		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	764					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		AGCAGGCGCTCGAAGGCGGTC	0.632			NA											27	130					5.77227e-19	1.02636e-18	0.008361	1	0
POMC	5443	broad.mit.edu	37	2	25384028	25384028	+	Silent	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:25384028G>T	uc002rfy.1	-	4	989	c.726C>A	c.(724-726)ACC>ACA	p.T242T	POMC_uc002rfz.1_Silent_p.T242T|POMC_uc002rga.1_Silent_p.T242T	NM_001035256	NP_001030333	P01189	COLI_HUMAN	proopiomelanocortin preproprotein	242					cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)	TCTTCTCGGAGGTCATGAAAC	0.642	Colon(110;1515 1566 8452 10082 43216)		NA											9	45					1.58986e-06	2.26663e-06	0.008291	1	0
ALK	238	broad.mit.edu	37	2	29551314	29551314	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:29551314C>A	uc002rmy.2	-	6	2223	c.1316G>T	c.(1315-1317)AGC>ATC	p.S439I		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	439	LDL-receptor class A.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	AGTGAAGGAGCTCTGCAGGGC	0.587			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				6	61					1.06961e-07	1.61206e-07	0.00308	1	0
SPRED2	200734	broad.mit.edu	37	2	65561881	65561881	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:65561881C>A	uc002sdr.3	-	3	766	c.231G>T	c.(229-231)AAG>AAT	p.K77N	SPRED2_uc010fcw.2_Missense_Mutation_p.K74N|SPRED2_uc010fcx.1_Intron	NM_181784	NP_861449	Q7Z698	SPRE2_HUMAN	sprouty-related protein with EVH-1 domain 2	77	WH1.				inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			ovary(1)|lung(1)|central_nervous_system(1)	3						AGACCAAGTCCTTTCTTACAT	0.448			NA											27	145					1.88708e-17	3.29979e-17	0.008361	1	0
ALMS1	7840	broad.mit.edu	37	2	73680958	73680958	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:73680958C>G	uc002sje.1	+	10	7418	c.7307C>G	c.(7306-7308)TCT>TGT	p.S2436C	ALMS1_uc002sjf.1_Missense_Mutation_p.S2392C|ALMS1_uc002sjg.2_Missense_Mutation_p.S1822C|ALMS1_uc002sjh.1_Missense_Mutation_p.S1822C	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2434					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TTACCAGAGTCTTTGGAATCA	0.393			NA											9	75					0	0	0.006214	0	0
DUSP11	8446	broad.mit.edu	37	2	74000985	74000985	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:74000985C>A	uc002sjp.2	-	4	558	c.516G>T	c.(514-516)GAG>GAT	p.E172D	DUSP11_uc002sjq.3_Missense_Mutation_p.E172D	NM_003584	NP_003575	O75319	DUS11_HUMAN	dual specificity phosphatase 11	125					RNA processing	nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|RNA binding			skin(1)	1						TAAAAATAGTCTCATCATCAG	0.308			NA											22	154					6.33239e-15	1.06891e-14	0.001523	1	0
REG1A	5967	broad.mit.edu	37	2	79349171	79349171	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:79349171G>T	uc002snz.2	+	4	344	c.241G>T	c.(241-243)GGT>TGT	p.G81C	REG1A_uc010ffx.1_3'UTR|REG1A_uc010ysd.1_Missense_Mutation_p.G81C	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	81	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						CCAGGCCGAGGGTGCCTTTGT	0.517			NA											12	105					7.93312e-07	1.14129e-06	0.00245	1	0
ANKRD36	375248	broad.mit.edu	37	2	97860624	97860624	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:97860624G>A	uc010yva.1	+	40	2765	c.2521G>A	c.(2521-2523)GGA>AGA	p.G841R	ANKRD36_uc002sxo.2_Intron|ANKRD36_uc002sxp.3_RNA|ANKRD36_uc002sxq.1_Intron	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	841											0						TATAACCAGAGGAAAAAAGGA	0.338			NA											3	14					0	0	0.004672	0	0
RANBP2	5903	broad.mit.edu	37	2	109374925	109374925	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:109374925G>T	uc002tem.3	+	18	2649	c.2523G>T	c.(2521-2523)TGG>TGT	p.W841C		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	841					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						CTCATCGTTGGCCCACAGAGA	0.388			NA											46	333					7.05121e-23	1.27526e-22	0.002522	1	0
MERTK	10461	broad.mit.edu	37	2	112786085	112786085	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:112786085G>A	uc002thk.1	+	19	2766	c.2644G>A	c.(2644-2646)GAG>AAG	p.E882K	MERTK_uc002thl.1_Missense_Mutation_p.E706K	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	882	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						GGAGAGCTCTGAGGGCCTGGC	0.527			NA											7	156					0	0	0.001984	0	0
GPR148	344561	broad.mit.edu	37	2	131486884	131486884	+	Missense_Mutation	SNP	C	C	T	rs142929079		TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:131486884C>T	uc002trv.1	+	1	162	c.160C>T	c.(160-162)CTT>TTT	p.L54F		NM_207364	NP_997247	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	54	Helical; Name=1; (Potential).			CMPQAASNTSLGLGDLRVPSSMLYWLFLPSSLLAAA -> S S (in Ref. 2; AAP34196).		integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1	Colorectal(110;0.1)					CTGGCTTTTCCTTCCCTCAAG	0.632			NA											3	50					0	0	0.004672	0	0
FAM123C	205147	broad.mit.edu	37	2	131521386	131521386	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:131521386G>T	uc002trw.2	+	2	1931	c.1741G>T	c.(1741-1743)GAG>TAG	p.E581*	FAM123C_uc010fmv.2_Nonsense_Mutation_p.E581*|FAM123C_uc010fms.1_Nonsense_Mutation_p.E581*|FAM123C_uc010fmt.1_Nonsense_Mutation_p.E581*|FAM123C_uc010fmu.1_Nonsense_Mutation_p.E581*	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	581										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		GCTCGCCGGAGAGAGCAAGGC	0.657			NA											7	57					2.0095e-06	2.83299e-06	0.001984	1	0
PKP4	8502	broad.mit.edu	37	2	159488326	159488326	+	Silent	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:159488326G>T	uc002tzv.2	+	8	1475	c.1215G>T	c.(1213-1215)GTG>GTT	p.V405V	PKP4_uc002tzt.1_Silent_p.V257V|PKP4_uc002tzu.2_Silent_p.V405V|PKP4_uc002tzw.2_Silent_p.V405V|PKP4_uc002tzx.2_Silent_p.V63V|PKP4_uc002tzy.1_Silent_p.V63V|PKP4_uc002tzz.1_Silent_p.V403V|PKP4_uc002uaa.2_Silent_p.V257V	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	405					cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						GTTCTGCCGTGTCTCCCGACT	0.498			NA								HNSCC(62;0.18)			17	138					1.99824e-07	2.98322e-07	0.00499	1	0
SCRN3	79634	broad.mit.edu	37	2	175265748	175265748	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:175265748A>T	uc002uiq.2	+	4	460	c.372A>T	c.(370-372)GAA>GAT	p.E124D	SCRN3_uc010zen.1_Missense_Mutation_p.E117D|SCRN3_uc010zeo.1_Intron	NM_024583	NP_078859	Q0VDG4	SCRN3_HUMAN	secernin 3	124					proteolysis		dipeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.229)			ATACAGCTGAAAAAGCCCTCA	0.313			NA											4	22					0	0	0.000602	0	0
TTN	7273	broad.mit.edu	37	2	179544735	179544735	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:179544735C>T	uc010zfg.1	-	137	29958	c.29734G>A	c.(29734-29736)GAG>AAG	p.E9912K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E6573K|TTN_uc010fre.1_Intron|TTN_uc002una.1_5'Flank|TTN_uc010frf.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10839							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAACTTCCTCTTCAAAGGCA	0.373			NA											10	72					0	0	0.000978	0	0
TTN	7273	broad.mit.edu	37	2	179560074	179560074	+	Splice_Site	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:179560074C>A	uc010zfg.1	-	112	27762	c.27538_splice	c.e112+1	p.V9180_splice	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Splice_Site_p.V5841_splice|TTN_uc010fre.1_Splice_Site_p.V291_splice	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAATTACTTACCTTTAGGAGG	0.358			NA											7	99					0.00198382	0.00247684	0.001984	1	0
ITGA4	3676	broad.mit.edu	37	2	182339792	182339792	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:182339792T>A	uc002unu.2	+	3	1188	c.425T>A	c.(424-426)GTG>GAG	p.V142E	ITGA4_uc010zfl.1_Missense_Mutation_p.V142E	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	142	FG-GAP 2.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GGATCCATCGTGGTAGGTATT	0.448			NA											5	34					0	0	0.000602	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802546	185802546	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:185802546C>T	uc002uph.2	+	4	3017	c.2423C>T	c.(2422-2424)CCT>CTT	p.P808L		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	808						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CCCTGCAAGCCTAAAAAGAAA	0.388			NA											15	97					0	0	0.004007	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187693457	187693457	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:187693457C>T	uc002upu.1	-	9	1196	c.1156G>A	c.(1156-1158)GGA>AGA	p.G386R		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	386	RING-type 2.				apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			ATAACTTGTCCATCAATAGGG	0.348			NA											4	27					0	0	0.000248	0	0
COL5A2	1290	broad.mit.edu	37	2	189929292	189929292	+	Silent	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:189929292T>A	uc002uqk.2	-	25	1982	c.1707A>T	c.(1705-1707)CCA>CCT	p.P569P	COL5A2_uc010frx.2_Silent_p.P145P	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	569					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCCGAGCACCTGGAAGCCCAG	0.512			NA											10	59					0	0	0.008291	0	0
SATB2	23314	broad.mit.edu	37	2	200246493	200246493	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:200246493C>A	uc002uuy.1	-	4	1214	c.397G>T	c.(397-399)GAT>TAT	p.D133Y	SATB2_uc010fsq.1_Intron|SATB2_uc002uuz.1_Missense_Mutation_p.D133Y|SATB2_uc002uva.1_Missense_Mutation_p.D133Y	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	133						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						TCGGGTGCATCTGTCACATAA	0.433	Colon(30;262 767 11040 24421 36230)		NA											5	65					1.23904e-05	1.69033e-05	0.000602	1	0
ZDBF2	57683	broad.mit.edu	37	2	207169464	207169464	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:207169464T>C	uc002vbp.2	+	5	462	c.212T>C	c.(211-213)GTG>GCG	p.V71A		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	71							nucleic acid binding|zinc ion binding			ovary(3)	3						GAGACACATGTGAATACTGGG	0.373			NA											6	57					0	0	0.001168	0	0
FAM119A	151194	broad.mit.edu	37	2	208489097	208489097	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:208489097C>T	uc002vcf.2	-	2	163	c.3G>A	c.(1-3)ATG>ATA	p.M1I	FAM119A_uc002vce.2_Missense_Mutation_p.M1I|FAM119A_uc010fuk.1_Missense_Mutation_p.M1I|FAM119A_uc002vcg.3_Missense_Mutation_p.M1I	NM_145280	NP_660323	Q8WXB1	MT21A_HUMAN	hypothetical protein LOC151194	1						integral to membrane	methyltransferase activity				0				LUSC - Lung squamous cell carcinoma(261;0.0705)|Epithelial(149;0.131)|Lung(261;0.135)		GCACGAGGGCCATTCCGCCTG	0.522			NA											7	61					0	0	0.004482	0	0
MAP2	4133	broad.mit.edu	37	2	210560774	210560774	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:210560774G>T	uc002vde.1	+	7	4128	c.3880G>T	c.(3880-3882)GTA>TTA	p.V1294L	MAP2_uc002vdc.1_Missense_Mutation_p.V1294L|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.V1290L	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1294					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TTTCATCACTGTAGTGCAAAC	0.527	Pancreas(27;423 979 28787 29963)		NA											24	103					9.95505e-16	1.68942e-15	0.002299	1	0
ERBB4	2066	broad.mit.edu	37	2	212576896	212576896	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:212576896C>A	uc002veg.1	-	9	1101	c.1003G>T	c.(1003-1005)GAT>TAT	p.D335Y	ERBB4_uc002veh.1_Missense_Mutation_p.D335Y|ERBB4_uc010zji.1_Missense_Mutation_p.D335Y|ERBB4_uc010zjj.1_Missense_Mutation_p.D335Y|ERBB4_uc010fut.1_Missense_Mutation_p.D335Y	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	335	Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CCAATGCCATCACAAGCTGTA	0.353			NA								TSP Lung(8;0.080)			7	45					0.00198382	0.00247684	0.001984	1	0
PNKD	25953	broad.mit.edu	37	2	219206749	219206749	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:219206749C>G	uc002vhn.2	+	7	807	c.663C>G	c.(661-663)ATC>ATG	p.I221M	PNKD_uc002vhq.2_Missense_Mutation_p.I197M	NM_015488	NP_056303	Q8N490	PNKD_HUMAN	myofibrillogenesis regulator 1 isoform 1	221						membrane|mitochondrion|nucleus	hydroxyacylglutathione hydrolase activity|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;7.33e-07)|all cancers(144;0.000133)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGCTTCAGATCCGGGCCCTGG	0.602			NA											7	58					0	0	0.00308	0	0
C2orf52	151477	broad.mit.edu	37	2	232373893	232373893	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:232373893C>G	uc002vrx.1	-	3	526	c.198G>C	c.(196-198)AGG>AGC	p.R66S		NR_024079				RecName: Full=Uncharacterized protein C2orf52;												0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;5.72e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)		ACTCACTGTTCCTGTCTTCAT	0.502			NA											17	275					0	0	0.00499	0	0
UGT1A5	54579	broad.mit.edu	37	2	234681013	234681013	+	Silent	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:234681013C>G	uc002vuw.2	+	5	1413	c.1413C>G	c.(1411-1413)GGC>GGG	p.G471G	UGT1A8_uc002vup.2_Silent_p.G467G|UGT1A10_uc002vur.2_Silent_p.G467G|UGT1A9_uc002vus.2_Silent_p.G467G|UGT1A7_uc002vut.2_Silent_p.G467G|UGT1A6_uc002vuu.2_Silent_p.G202G|UGT1A6_uc002vuv.3_Silent_p.G469G|UGT1A4_uc002vux.2_Silent_p.G471G|UGT1A3_uc002vuy.2_Silent_p.G471G|UGT1A9_uc002vva.2_RNA|UGT1A1_uc002vvb.2_Silent_p.G470G	NM_019078	NP_061951	P35504	UD15_HUMAN	UDP glycosyltransferase 1 family, polypeptide A5	471					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		GGCACAAGGGCGCGCCACACC	0.627			NA											10	120					0	0	0.008291	0	0
COL6A3	1293	broad.mit.edu	37	2	238283131	238283131	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr2:238283131G>C	uc002vwl.2	-	8	3888	c.3603C>G	c.(3601-3603)ATC>ATG	p.I1201M	COL6A3_uc002vwo.2_Missense_Mutation_p.I995M|COL6A3_uc010znj.1_Missense_Mutation_p.I594M|COL6A3_uc002vwq.2_Missense_Mutation_p.I995M|COL6A3_uc002vwr.2_Missense_Mutation_p.I794M	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1201	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCCTCTCAGAGATGACCTGTT	0.612			NA											6	51					0	0	0.001168	0	0
BMP2	650	broad.mit.edu	37	20	6759046	6759046	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr20:6759046C>G	uc002wmu.1	+	3	1286	c.501C>G	c.(499-501)TTC>TTG	p.F167L		NM_001200	NP_001191	P12643	BMP2_HUMAN	bone morphogenetic protein 2 preproprotein	167					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			ovary(1)|breast(1)	2					Simvastatin(DB00641)	ATAGCAGTTTCCATCACCGAA	0.413			NA											5	64					0	0	0.001168	0	0
ANKRD5	63926	broad.mit.edu	37	20	10030676	10030676	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr20:10030676G>A	uc002wno.2	+	7	1852	c.1459G>A	c.(1459-1461)GAT>AAT	p.D487N	uc002wnn.1_Intron|ANKRD5_uc002wnp.2_Missense_Mutation_p.D487N|ANKRD5_uc010gbz.2_Missense_Mutation_p.D298N	NM_022096	NP_071379	Q9NU02	ANKR5_HUMAN	ankyrin repeat domain protein 5	487							calcium ion binding			ovary(1)|breast(1)	2						TTGGTACATTGATGATTCAGA	0.398			NA											41	119					0	0	0.00874	0	0
C20orf26	26074	broad.mit.edu	37	20	20051546	20051546	+	Silent	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr20:20051546C>A	uc002wru.2	+	3	268	c.192C>A	c.(190-192)ATC>ATA	p.I64I	C20orf26_uc010gcw.1_Silent_p.I18I|C20orf26_uc010zse.1_Silent_p.I64I|C20orf26_uc010zsf.1_Silent_p.I64I	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	64										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		AGGAGGAGATCATGGCCCAGG	0.488			NA											6	52					0.00116845	0.00148222	0.001168	1	0
CTCFL	140690	broad.mit.edu	37	20	56093924	56093924	+	Missense_Mutation	SNP	C	C	T	rs143392924		TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr20:56093924C>T	uc010gix.1	-	4	1611	c.949G>A	c.(949-951)GAC>AAC	p.D317N	CTCFL_uc010giw.1_Missense_Mutation_p.D317N|CTCFL_uc002xym.2_Missense_Mutation_p.D317N|CTCFL_uc010giz.1_5'UTR|CTCFL_uc010giy.1_5'UTR|CTCFL_uc010gja.1_Missense_Mutation_p.D317N|CTCFL_uc010gjb.1_Missense_Mutation_p.D317N|CTCFL_uc010gjc.1_Missense_Mutation_p.D317N|CTCFL_uc010gjd.1_Missense_Mutation_p.D317N|CTCFL_uc010gje.2_Missense_Mutation_p.D317N|CTCFL_uc010gjf.2_Missense_Mutation_p.D112N|CTCFL_uc010gjg.2_Missense_Mutation_p.D49N|CTCFL_uc010gjh.1_Missense_Mutation_p.D317N|CTCFL_uc010gji.1_Missense_Mutation_p.D112N|CTCFL_uc010gjj.1_Missense_Mutation_p.D317N|CTCFL_uc010gjk.1_Missense_Mutation_p.D317N|CTCFL_uc010gjl.1_Missense_Mutation_p.D317N	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	317	C2H2-type 3.				cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding	p.D317N(1)		ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			ATGTTGCAGTCGTTACACTTG	0.398			NA											23	67					0	0	0.00278	0	0
ZNF831	128611	broad.mit.edu	37	20	57769634	57769634	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr20:57769634G>T	uc002yan.2	+	1	3560	c.3560G>T	c.(3559-3561)TGC>TTC	p.C1187F		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1187						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					ACGTGGTGTTGCCTGAGCCGC	0.642			NA											21	20					3.8784e-16	6.61733e-16	0.001882	1	0
LIPI	149998	broad.mit.edu	37	21	15561477	15561477	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr21:15561477C>G	uc002yjm.2	-	2	383	c.373G>C	c.(373-375)GAA>CAA	p.E125Q	LIPI_uc010gkw.1_Missense_Mutation_p.E58Q	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	104					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		TTCATATCTTCTTCATTCAGC	0.393			NA											10	62					0	0	0.006214	0	0
KRTAP19-7	337974	broad.mit.edu	37	21	31933508	31933508	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr21:31933508C>A	uc011adb.1	-	1	101	c.101G>T	c.(100-102)AGA>ATA	p.R34I		NM_181614	NP_853645	Q3SYF9	KR197_HUMAN	keratin associated protein 19-7	34						intermediate filament					0						ATAGCCCAGTCTGCGGAAGCT	0.537			NA											26	131					2.41591e-17	4.2013e-17	0.004656	1	0
SYNJ1	8867	broad.mit.edu	37	21	34017287	34017287	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr21:34017287C>G	uc002yqh.2	-	26	3538	c.3538G>C	c.(3538-3540)GAA>CAA	p.E1180Q	SYNJ1_uc011ads.1_Intron|SYNJ1_uc002yqf.2_Missense_Mutation_p.E1141Q|SYNJ1_uc002yqg.2_Intron|SYNJ1_uc002yqi.2_Missense_Mutation_p.E1180Q|SYNJ1_uc002yqe.3_5'Flank	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	1141	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						CCTCCAAATTCCTTTCTAGTG	0.343			NA											7	87					0	0	0.001984	0	0
PCBP3	54039	broad.mit.edu	37	21	47361589	47361589	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr21:47361589C>T	uc002zhq.1	+	14	1210	c.1085C>T	c.(1084-1086)ACG>ATG	p.T362M	PCBP3_uc002zhp.1_Missense_Mutation_p.T342M|PCBP3_uc002zhs.1_Missense_Mutation_p.T336M|PCBP3_uc002zhr.1_Missense_Mutation_p.T361M|PCBP3_uc002zht.1_Missense_Mutation_p.T352M	NM_020528	NP_065389	P57721	PCBP3_HUMAN	poly(rC) binding protein 3 isoform 1	362					mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			skin(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		TCCAGGCTGACGTCCGAGGTC	0.652			NA											14	52					0	0	0.00245	0	0
SEZ6L	23544	broad.mit.edu	37	22	26690269	26690269	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr22:26690269G>A	uc003acb.2	+	3	1003	c.847G>A	c.(847-849)GTG>ATG	p.V283M	SEZ6L_uc003acc.2_Missense_Mutation_p.V283M|SEZ6L_uc011akc.1_Missense_Mutation_p.V283M|SEZ6L_uc003acd.2_Missense_Mutation_p.V283M|SEZ6L_uc011akd.1_Missense_Mutation_p.V283M|SEZ6L_uc003ace.2_Missense_Mutation_p.V283M|SEZ6L_uc003acf.1_Missense_Mutation_p.V56M|SEZ6L_uc010gvc.1_Missense_Mutation_p.V56M	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	283	CUB 1.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						TCTCTGCAGTGTGAGCTTCTC	0.517			NA											24	128					0	0	0.005443	0	0
DDX17	10521	broad.mit.edu	37	22	38890696	38890696	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr22:38890696T>A	uc003avy.3	-	8	1256	c.1153A>T	c.(1153-1155)AGT>TGT	p.S385C	DDX17_uc003avx.3_Missense_Mutation_p.S385C|DDX17_uc011anu.1_Missense_Mutation_p.S298C	NM_001098504	NP_001091974	Q92841	DDX17_HUMAN	DEAD box polypeptide 17 isoform 3	306					RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity			skin(3)|upper_aerodigestive_tract(1)	4	Melanoma(58;0.0286)					TGGTTGGCACTCAACTCCAGA	0.428	Ovarian(55;1085 1454 6392 21425)		NA											39	100					0	0	0.004289	0	0
CHL1	10752	broad.mit.edu	37	3	447299	447299	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:447299G>T	uc003bou.2	+	27	3803	c.3532G>T	c.(3532-3534)GAT>TAT	p.D1178Y	CHL1_uc003bot.2_Missense_Mutation_p.D1194Y|CHL1_uc011asi.1_Missense_Mutation_p.D1141Y	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	1178	Cytoplasmic (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CTTCAGTGAAGATGGATCATT	0.468			NA											8	61					7.48243e-07	1.08633e-06	0.006214	1	0
WNT7A	7476	broad.mit.edu	37	3	13896097	13896097	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:13896097C>A	uc003bye.1	-	3	807	c.502G>T	c.(502-504)GAT>TAT	p.D168Y		NM_004625	NP_004616	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family,	168					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			ovary(2)|breast(1)	3						TCCCGGGCATCCACAAAGACC	0.622			NA											24	130					4.26978e-12	6.93018e-12	0.00333	1	0
OXSM	54995	broad.mit.edu	37	3	25833258	25833258	+	Silent	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:25833258C>G	uc003cdn.2	+	2	854	c.747C>G	c.(745-747)TCC>TCG	p.S249S	NGLY1_uc011awo.1_5'Flank|OXSM_uc011awp.1_Intron|OXSM_uc010hfh.2_Intron	NM_017897	NP_060367	Q9NWU1	OXSM_HUMAN	3-oxoacyl-ACP synthase, mitochondrial isoform 1	249					acyl-CoA metabolic process|medium-chain fatty acid biosynthetic process|short-chain fatty acid biosynthetic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity			ovary(1)|breast(1)	2						CTGGGTTTTCCAGAGCCCGGG	0.478			NA											16	134					0	0	0.003163	0	0
NEK10	152110	broad.mit.edu	37	3	27332233	27332233	+	Missense_Mutation	SNP	T	T	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:27332233T>G	uc003cdt.1	-	20	1892	c.1618A>C	c.(1618-1620)AGT>CGT	p.S540R	NEK10_uc003cds.1_Intron	NM_199347	NP_955379	Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10 isoform 3	540	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						TTTTGACCACTATGCTTTCTA	0.348			NA											4	50					0	0	0.001984	0	0
LRRC2	79442	broad.mit.edu	37	3	46592962	46592962	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:46592962C>A	uc010hji.2	-	2	484	c.120G>T	c.(118-120)TTG>TTT	p.L40F	LRRC2_uc003cpu.3_Missense_Mutation_p.L40F	NM_024512	NP_078788	Q9BYS8	LRRC2_HUMAN	leucine rich repeat containing 2	40										ovary(1)	1		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)		CGTACTTCTCCAAGGCGCTCT	0.468			NA											6	95					3.59834e-05	4.82573e-05	0.001168	1	0
SMARCC1	6599	broad.mit.edu	37	3	47752263	47752263	+	Silent	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:47752263G>A	uc003crq.2	-	9	946	c.828C>T	c.(826-828)TTC>TTT	p.F276F	SMARCC1_uc011bbd.1_Silent_p.F167F	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	276					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		TCCATTCATTGAAAATATCAG	0.338			NA											5	67					0	0	0.000602	0	0
COL7A1	1294	broad.mit.edu	37	3	48620085	48620085	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:48620085C>A	uc003ctz.2	-	44	4521	c.4520G>T	c.(4519-4521)GGG>GTG	p.G1507V		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1507	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCCTGGCAGCCCCTGGAGGAG	0.637			NA											7	31					0.00198382	0.00247684	0.001984	1	0
NCKIPSD	51517	broad.mit.edu	37	3	48718899	48718899	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:48718899C>T	uc003cun.2	-	5	1007	c.913G>A	c.(913-915)GAG>AAG	p.E305K	NCKIPSD_uc003cum.2_Missense_Mutation_p.E298K|NCKIPSD_uc010hkh.1_Missense_Mutation_p.E305K	NM_016453	NP_057537	Q9NZQ3	SPN90_HUMAN	NCK interacting protein with SH3 domain isoform	305					cytoskeleton organization|NLS-bearing substrate import into nucleus|signal transduction	intermediate filament|nucleus	cytoskeletal protein binding|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ACAGCCGCCTCAGCTGCTGCC	0.602			NA											8	52					0	0	0.004482	0	0
RBM6	10180	broad.mit.edu	37	3	50005024	50005024	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:50005024G>A	uc003cyc.2	+	3	299	c.166G>A	c.(166-168)GAT>AAT	p.D56N	RBM6_uc011bdh.1_RNA|RBM6_uc010hlc.1_Intron|RBM6_uc003cyd.2_Intron|RBM6_uc003cye.2_Intron|RBM6_uc011bdi.1_Intron|RBM6_uc010hld.1_Intron|RBM6_uc010hle.1_Intron|RBM6_uc010hlf.1_Intron	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	56					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		ACTTCCCTTTGATTTCCAGGG	0.527			NA											13	133					0	0	0.001855	0	0
STAB1	23166	broad.mit.edu	37	3	52550187	52550187	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:52550187C>A	uc003dej.2	+	38	4151	c.4077C>A	c.(4075-4077)CAC>CAA	p.H1359Q	STAB1_uc003dek.1_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1359	Laminin EGF-like 1.|Extracellular (Potential).				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCCACTGCCACGAGGGCTTCC	0.701			NA											7	38					5.18039e-06	7.1912e-06	0.00308	1	0
ARHGEF3	50650	broad.mit.edu	37	3	56771215	56771215	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:56771215C>A	uc003dig.2	-	8	1208	c.1039G>T	c.(1039-1041)GTG>TTG	p.V347L	ARHGEF3_uc011bew.1_Missense_Mutation_p.V347L|ARHGEF3_uc003dih.2_Missense_Mutation_p.V379L|ARHGEF3_uc011bev.1_Missense_Mutation_p.V318L|ARHGEF3_uc003dif.2_Missense_Mutation_p.V353L|ARHGEF3_uc010hmy.1_Missense_Mutation_p.V145L|ARHGEF3_uc003dii.2_Missense_Mutation_p.V347L	NM_019555	NP_062455	Q9NR81	ARHG3_HUMAN	Rho guanine nucleotide exchange factor 3 isoform	347	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0161)|Kidney(284;0.019)|OV - Ovarian serous cystadenocarcinoma(275;0.193)		CTACTTACCACGCCCCGATTG	0.473			NA											8	94					3.09899e-07	4.56199e-07	0.004482	1	0
CNTN3	5067	broad.mit.edu	37	3	74334570	74334570	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:74334570C>A	uc003dpm.1	-	19	2670	c.2590G>T	c.(2590-2592)GCC>TCC	p.A864S		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	864	Fibronectin type-III 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CGTAGTCTGGCTGATGTCTCA	0.547			NA											20	167					1.87028e-06	2.66042e-06	0.001882	1	0
CD86	942	broad.mit.edu	37	3	121825068	121825068	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:121825068G>A	uc003eet.2	+	4	540	c.424G>A	c.(424-426)GTA>ATA	p.V142I	CD86_uc011bjo.1_Missense_Mutation_p.V60I|CD86_uc011bjp.1_Missense_Mutation_p.V30I|CD86_uc003eeu.2_Missense_Mutation_p.V136I	NM_175862	NP_787058	P42081	CD86_HUMAN	CD86 antigen isoform 1	142	Extracellular (Potential).				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			pancreas(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	ACCTGAAATAGTACCAATTTC	0.338	GBM(67;1379 1389 36064 39806)		NA											8	33					0	0	0.00308	0	0
KALRN	8997	broad.mit.edu	37	3	124201673	124201673	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:124201673G>A	uc003ehg.2	+	28	4331	c.4204G>A	c.(4204-4206)GGT>AGT	p.G1402S	KALRN_uc010hrv.1_Missense_Mutation_p.G1393S|KALRN_uc003ehf.1_Missense_Mutation_p.G1402S|KALRN_uc011bjy.1_Missense_Mutation_p.G1393S|KALRN_uc003ehh.1_Missense_Mutation_p.G748S	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1402	DH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						ACAGCGGCATGGTCTGGCCAA	0.512			NA											23	117					0	0	0.00278	0	0
GRK7	131890	broad.mit.edu	37	3	141535733	141535733	+	Silent	SNP	T	T	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:141535733T>C	uc011bnd.1	+	4	1587	c.1503T>C	c.(1501-1503)GAT>GAC	p.D501D		NM_139209	NP_631948	Q8WTQ7	GRK7_HUMAN	G-protein-coupled receptor kinase 7 precursor	501	AGC-kinase C-terminal.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						ATGACAAAGATAAGCAGTTCT	0.443			NA											27	152					0	0	0.007291	0	0
TNIK	23043	broad.mit.edu	37	3	170819320	170819320	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:170819320C>T	uc003fhh.2	-	22	2854	c.2509G>A	c.(2509-2511)GAA>AAA	p.E837K	TNIK_uc003fhi.2_Missense_Mutation_p.E782K|TNIK_uc003fhj.2_Missense_Mutation_p.E808K|TNIK_uc003fhk.2_Missense_Mutation_p.E829K|TNIK_uc003fhl.2_Missense_Mutation_p.E753K|TNIK_uc003fhm.2_Missense_Mutation_p.E774K|TNIK_uc003fhn.2_Missense_Mutation_p.E800K|TNIK_uc003fho.2_Missense_Mutation_p.E745K|TNIK_uc003fhg.2_Missense_Mutation_p.E15K	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	837	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TCGCTACTTTCTGACTCCTCA	0.483			NA											29	295					0	0	0.00632	0	0
ZMAT3	64393	broad.mit.edu	37	3	178785371	178785371	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:178785371C>A	uc003fjg.2	-	2	429	c.170G>T	c.(169-171)GGG>GTG	p.G57V	ZMAT3_uc010hxa.2_Missense_Mutation_p.G57V|ZMAT3_uc003fji.2_Missense_Mutation_p.G57V	NM_022470	NP_071915	Q9HA38	ZMAT3_HUMAN	p53 target zinc finger protein isoform 1	57					apoptosis|protein transport|regulation of growth|response to DNA damage stimulus|transmembrane transport	nucleolus	RNA binding|zinc ion binding			ovary(2)	2	all_cancers(143;3.31e-18)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;6.74e-27)|GBM - Glioblastoma multiforme(14;0.00448)|BRCA - Breast invasive adenocarcinoma(182;0.0527)			GTCTTGCTCCCCTCCCTTCGA	0.547			NA											29	116					4.87955e-14	8.19299e-14	0.005443	1	0
KLHL6	89857	broad.mit.edu	37	3	183211915	183211915	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:183211915T>A	uc003flr.2	-	5	1360	c.1302A>T	c.(1300-1302)AGA>AGT	p.R434S	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_3'UTR|KLHL6_uc010hxk.1_RNA	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	434	Kelch 3.									haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			CATTGTTGATTCTCTGTAAGC	0.463			NA											25	215					0	0	0.005443	0	0
TP63	8626	broad.mit.edu	37	3	189612133	189612133	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:189612133G>T	uc003fry.2	+	14	1974	c.1885G>T	c.(1885-1887)GGC>TGC	p.G629C	TP63_uc003frz.2_3'UTR|TP63_uc010hzc.1_3'UTR|TP63_uc003fsc.2_Missense_Mutation_p.G535C|TP63_uc003fsd.2_3'UTR|TP63_uc010hzd.1_Missense_Mutation_p.G450C	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	629	Transactivation inhibition.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		AGTCAGTGTGGGCTCCAGTGA	0.582			NA							Hay-Wells_syndrome	HNSCC(45;0.13)			18	91					1.33834e-09	2.09695e-09	0.007413	1	0
UTS2D	257313	broad.mit.edu	37	3	190993124	190993124	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:190993124A>G	uc003fsu.2	-	8	1038	c.251T>C	c.(250-252)CTA>CCA	p.L84P		NM_198152	NP_937795	Q765I0	UTS2B_HUMAN	urotensin 2 domain containing precursor	84						extracellular region	hormone activity				0	all_cancers(143;1.77e-09)|Ovarian(172;0.103)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000214)		CTGTTCTTTTAGCTTTTCCAG	0.299			NA											20	101					0	0	0.001523	0	0
GP5	2814	broad.mit.edu	37	3	194118856	194118856	+	Silent	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:194118856G>C	uc003ftv.1	-	2	187	c.156C>G	c.(154-156)CTC>CTG	p.L52L		NM_004488	NP_004479	P40197	GPV_HUMAN	glycoprotein V (platelet) precursor	52	Extracellular (Potential).				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				skin(2)|breast(1)	3	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		GGATGTGCGTGAGGTTGGTGG	0.677			NA											12	70					0	0	0.001368	0	0
TLR1	7096	broad.mit.edu	37	4	38799759	38799759	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:38799759A>G	uc003gtl.2	-	4	968	c.694T>C	c.(694-696)TAC>CAC	p.Y232H		NM_003263	NP_003254	Q15399	TLR1_HUMAN	toll-like receptor 1 precursor	232	Extracellular (Potential).				cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			lung(2)|skin(2)|prostate(1)	5						CTTAGGAAGTAAGAACATTTG	0.313	GBM(5;216 373 40795 46382)		NA											4	60					0	0	0.000248	0	0
FAM114A1	92689	broad.mit.edu	37	4	38893400	38893400	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:38893400G>T	uc003gtn.2	+	4	561	c.385G>T	c.(385-387)GGC>TGC	p.G129C	FAM114A1_uc011byh.1_Translation_Start_Site	NM_138389	NP_612398	Q8IWE2	NXP20_HUMAN	hypothetical protein LOC92689	129						cytoplasm				ovary(1)	1						AGGATGGGCAGGCTGGGGATC	0.463			NA											18	61					3.41278e-10	5.41426e-10	0.00499	1	0
LRRC66	339977	broad.mit.edu	37	4	52861433	52861433	+	Silent	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:52861433T>A	uc003gzi.2	-	4	1768	c.1755A>T	c.(1753-1755)ACA>ACT	p.T585T		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	585						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						AGAGGGAAGCTGTTATTTCTC	0.507			NA											12	181					0	0	0.001368	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182101	57182101	+	Silent	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:57182101G>T	uc003hbk.2	+	8	2824	c.2433G>T	c.(2431-2433)GTG>GTT	p.V811V	KIAA1211_uc010iha.2_Silent_p.V804V|KIAA1211_uc011bzz.1_Silent_p.V721V|KIAA1211_uc003hbm.1_Silent_p.V697V	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	811										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					AGAAAGTGGTGGCCCACACAG	0.582			NA											7	48					8.12818e-05	0.000106968	0.001984	1	0
UGT2B7	7364	broad.mit.edu	37	4	69962775	69962775	+	Silent	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:69962775T>A	uc003heg.3	+	1	583	c.537T>A	c.(535-537)ACT>ACA	p.T179T	UGT2B7_uc010ihq.2_Silent_p.T179T	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	179					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						CTGGCTACACTTTTGAAAAGC	0.403			NA											37	149					0	0	0.004289	0	0
ODAM	54959	broad.mit.edu	37	4	71062448	71062448	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:71062448G>A	uc003hfc.2	+	2	108	c.91G>A	c.(91-93)GAG>AAG	p.E31K		NM_017855	NP_060325	A1E959	ODAM_HUMAN	odontogenic ameloblast-associated protein	31					biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				ovary(3)|large_intestine(1)	4						CAATAGCAATGAGGTTAGTTT	0.323			NA											4	36					0	0	0.000602	0	0
CCDC158	339965	broad.mit.edu	37	4	77300479	77300479	+	Silent	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:77300479A>G	uc003hkb.3	-	8	1146	c.993T>C	c.(991-993)TCT>TCC	p.S331S	CCDC158_uc003hkd.2_Silent_p.S331S	NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	331	Potential.									skin(3)|ovary(2)|pancreas(1)	6						CCCTTAATTCAGAACGTAGCT	0.383			NA											3	81					0	0	0.000602	0	0
SEC31A	22872	broad.mit.edu	37	4	83791564	83791564	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:83791564T>C	uc003hnf.2	-	8	960	c.796A>G	c.(796-798)ATT>GTT	p.I266V	SEC31A_uc003hne.2_Missense_Mutation_p.I38V|SEC31A_uc011ccl.1_Missense_Mutation_p.I266V|SEC31A_uc003hnl.2_Missense_Mutation_p.I266V|SEC31A_uc003hng.2_Missense_Mutation_p.I266V|SEC31A_uc003hnh.2_Missense_Mutation_p.I266V|SEC31A_uc003hni.2_Missense_Mutation_p.I266V|SEC31A_uc003hnj.2_Missense_Mutation_p.I266V|SEC31A_uc011ccm.1_Missense_Mutation_p.I261V|SEC31A_uc011ccn.1_Missense_Mutation_p.I266V|SEC31A_uc003hnk.2_Missense_Mutation_p.I266V|SEC31A_uc003hnm.2_Missense_Mutation_p.I266V|SEC31A_uc003hnn.1_Missense_Mutation_p.I266V|SEC31A_uc003hno.2_Missense_Mutation_p.I266V	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	266	Interaction with SEC13.|WD 5.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				CTCCAAGCAATTGCCAAAATC	0.388			NA											7	118					0	0	0.00308	0	0
GRID2	2895	broad.mit.edu	37	4	94690553	94690553	+	Silent	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:94690553G>A	uc011cdt.1	+	15	2811	c.2553G>A	c.(2551-2553)CTG>CTA	p.L851L	GRID2_uc011cdu.1_Silent_p.L756L	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	851	Helical; (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TAGCCATGCTGGAGACGTGGT	0.483			NA											12	83					0	0	0.001368	0	0
SGMS2	166929	broad.mit.edu	37	4	108817064	108817064	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:108817064G>T	uc003hyl.3	+	3	910	c.355G>T	c.(355-357)GAT>TAT	p.D119Y	uc003hym.1_Intron|SGMS2_uc003hyn.2_Missense_Mutation_p.D119Y|SGMS2_uc003hyo.2_Missense_Mutation_p.D119Y	NM_001136258	NP_001129730	Q8NHU3	SMS2_HUMAN	sphingomyelin synthase 2	119					sphingomyelin biosynthetic process	integral to Golgi membrane|integral to plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			lung(1)	1				OV - Ovarian serous cystadenocarcinoma(123;2.95e-05)	Choline(DB00122)	CAAGTTTTTTGATTACATTGA	0.423			NA											9	79					0.000274275	0.000355043	0.004482	1	0
METTL14	57721	broad.mit.edu	37	4	119631390	119631390	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:119631390G>A	uc003icf.2	+	11	1420	c.1304G>A	c.(1303-1305)CGA>CAA	p.R435Q	METTL14_uc003icg.2_Missense_Mutation_p.R397Q	NM_020961	NP_066012	Q9HCE5	MTL14_HUMAN	methyltransferase like 14	435	Gly-rich.					nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity				0						TCTAACTTCCGAGGAGAAAGA	0.517			NA											4	53					0	0	0.000602	0	0
KIAA1109	84162	broad.mit.edu	37	4	123234842	123234842	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:123234842G>T	uc003ieh.2	+	58	10357	c.10312G>T	c.(10312-10314)GAA>TAA	p.E3438*	KIAA1109_uc003iel.1_Nonsense_Mutation_p.E1373*	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3438					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AGCAGCAGCTGGTAGGTTCAC	0.353			NA											13	75					7.93312e-07	1.14129e-06	0.00245	1	0
FAT4	79633	broad.mit.edu	37	4	126242685	126242685	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:126242685G>T	uc003ifj.3	+	1	5119	c.5119G>T	c.(5119-5121)GTG>TTG	p.V1707L		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1707	Cadherin 16.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TCTTTACCTGGTGGATGTTTA	0.398			NA											6	79					0.00116845	0.00148222	0.001168	1	0
INPP4B	8821	broad.mit.edu	37	4	143045852	143045852	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:143045852C>T	uc003iix.3	-	20	2377	c.1782G>A	c.(1780-1782)GTG>GTA	p.V594V	INPP4B_uc003iiw.3_Silent_p.V594V|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_Silent_p.V409V|INPP4B_uc011cho.1_RNA|INPP4B_uc011chp.1_Silent_p.V465V	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	594					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					CTCGGTTCACCACTTCTCCCA	0.517			NA											9	55					0	0	0.004482	0	0
MAB21L2	10586	broad.mit.edu	37	4	151504238	151504238	+	Silent	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:151504238C>G	uc003ilw.2	+	1	1162	c.57C>G	c.(55-57)CGC>CGG	p.R19R	LRBA_uc003ils.3_5'Flank|LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron|LRBA_uc010ipj.2_Intron	NM_006439	NP_006430	Q9Y586	MB212_HUMAN	mab-21-like protein 2	19					nervous system development	nucleus				ovary(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)		ACACTGAGCGCTGTCAGGCGC	0.592			NA											9	22					0	0	0.006214	0	0
MAP9	79884	broad.mit.edu	37	4	156273864	156273864	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:156273864C>G	uc003ios.2	-	13	1969	c.1705G>C	c.(1705-1707)GCT>CCT	p.A569P	MAP9_uc011cin.1_Missense_Mutation_p.A544P|MAP9_uc010iqa.1_RNA	NM_001039580	NP_001034669	Q49MG5	MAP9_HUMAN	aster-associated protein	569	Potential.				cell division|mitosis	cytoplasm|microtubule|spindle				ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		TTGAAAAAAGCTTCCTTTTTT	0.189			NA											8	40					0	0	0.00308	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156618236	156618236	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:156618236A>G	uc003iov.2	+	4	753	c.217A>G	c.(217-219)ACT>GCT	p.T73A	GUCY1A3_uc003iou.2_Missense_Mutation_p.T73A|GUCY1A3_uc010iqc.2_Missense_Mutation_p.T73A|GUCY1A3_uc003iow.2_Missense_Mutation_p.T73A|GUCY1A3_uc010iqd.2_Missense_Mutation_p.T73A|GUCY1A3_uc003iox.2_Missense_Mutation_p.T73A|GUCY1A3_uc003ioz.2_5'UTR|GUCY1A3_uc003ioy.2_Missense_Mutation_p.T73A|GUCY1A3_uc010iqe.2_5'UTR|GUCY1A3_uc003ipa.2_RNA|GUCY1A3_uc003ipb.2_Missense_Mutation_p.T73A	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	73					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CTATCTTCACACTTTGGCAGA	0.398			NA											8	98					0	0	0.004482	0	0
FSTL5	56884	broad.mit.edu	37	4	162463837	162463837	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:162463837C>A	uc003iqh.2	-	9	1460	c.1024G>T	c.(1024-1026)GTC>TTC	p.V342F	FSTL5_uc003iqi.2_Missense_Mutation_p.V341F|FSTL5_uc010iqv.2_Missense_Mutation_p.V341F	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	342	Ig-like 2.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		ACCCGGATGACTGGAGGAACT	0.393			NA											19	47					5.03518e-11	8.1101e-11	0.007413	1	0
AGA	175	broad.mit.edu	37	4	178361559	178361559	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:178361559C>T	uc003iuu.1	-	2	211	c.149G>A	c.(148-150)GGA>GAA	p.G50E	AGA_uc003iuv.1_5'Flank|AGA_uc003iuw.2_5'Flank	NM_000027	NP_000018	P20933	ASPG_HUMAN	aspartylglucosaminidase precursor	50					asparagine catabolic process via L-aspartate|protein deglycosylation|protein maturation	endoplasmic reticulum|intermediate filament cytoskeleton|lysosome|microtubule cytoskeleton	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity				0		all_lung(41;1.27e-09)|Lung NSC(41;1.1e-08)|Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Hepatocellular(41;0.148)|all_neural(102;0.164)|Colorectal(36;0.245)		all cancers(43;1.37e-22)|Epithelial(43;3.86e-20)|OV - Ovarian serous cystadenocarcinoma(60;3.8e-11)|Colorectal(24;6.98e-05)|GBM - Glioblastoma multiforme(59;0.000362)|COAD - Colon adenocarcinoma(29;0.000462)|STAD - Stomach adenocarcinoma(60;0.0029)|LUSC - Lung squamous cell carcinoma(193;0.0328)|READ - Rectum adenocarcinoma(43;0.163)		GGCAGAGCCTCCAGATGCTAA	0.453			NA											4	118					0	0	0.000602	0	0
LPCAT1	79888	broad.mit.edu	37	5	1494959	1494959	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:1494959C>A	uc003jcm.2	-	3	466	c.349G>T	c.(349-351)GTG>TTG	p.V117L		NM_024830	NP_079106	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	117	Lumenal (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		CGCCCCTTCACGGCCACCCGG	0.672			NA											6	61					0.00116845	0.00148222	0.001168	1	0
IRX1	79192	broad.mit.edu	37	5	3599846	3599846	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:3599846G>T	uc003jde.2	+	2	836	c.784G>T	c.(784-786)GCC>TCC	p.A262S		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	262						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						TTCTGCTCTTGCCCGGGACCA	0.682			NA											15	46					2.32078e-09	3.6273e-09	0.003163	1	0
ADCY2	108	broad.mit.edu	37	5	7789797	7789797	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:7789797T>A	uc003jdz.1	+	20	2579	c.2512T>A	c.(2512-2514)TTC>ATC	p.F838I	ADCY2_uc011cmo.1_Missense_Mutation_p.F658I|ADCY2_uc010itm.1_Missense_Mutation_p.F34I	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	838	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GAAGAACAAATTCAAAAAAGA	0.483			NA											8	275					0	0	0.006214	0	0
DNAH5	1767	broad.mit.edu	37	5	13737491	13737491	+	Silent	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:13737491C>A	uc003jfd.2	-	66	11367	c.11325G>T	c.(11323-11325)CTG>CTT	p.L3775L	DNAH5_uc003jfc.2_Intron	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3775	Potential.|AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CATCTTCTACCAGGGACCCCT	0.433			NA							Kartagener_syndrome				46	241					1.47857e-17	2.59982e-17	0.00361	1	0
TRIO	7204	broad.mit.edu	37	5	14479403	14479403	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:14479403C>T	uc003jff.2	+	42	6193	c.6187C>T	c.(6187-6189)CAA>TAA	p.Q2063*	TRIO_uc003jfg.2_RNA|TRIO_uc003jfh.1_Nonsense_Mutation_p.Q1712*	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2063	DH 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					AGCTTATTGTCAAAATAAACC	0.343			NA											11	161					0	0	0.000978	0	0
CDH18	1016	broad.mit.edu	37	5	19747105	19747105	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:19747105G>T	uc003jgc.2	-	3	846	c.469C>A	c.(469-471)CCA>ACA	p.P157T	CDH18_uc003jgd.2_Missense_Mutation_p.P157T|CDH18_uc011cnm.1_Missense_Mutation_p.P157T	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	157	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					GTGAATTTTGGAGCGTTGTCA	0.363			NA											93	121					6.78661e-64	1.24882e-63	0.00361	1	0
CDH12	1010	broad.mit.edu	37	5	21975400	21975400	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:21975400C>A	uc010iuc.2	-	3	784	c.326G>T	c.(325-327)GGG>GTG	p.G109V	CDH12_uc011cno.1_Missense_Mutation_p.G109V|CDH12_uc003jgk.2_Missense_Mutation_p.G109V	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	109	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						ATGAATGTCCCCTGTGGTTTC	0.493			NA								HNSCC(59;0.17)			58	171					7.05995e-25	1.28788e-24	0.00361	1	0
CDH9	1007	broad.mit.edu	37	5	26902655	26902655	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:26902655C>A	uc003jgs.1	-	7	1352	c.1183G>T	c.(1183-1185)GAT>TAT	p.D395Y		NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	395	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TCCTTTACATCTTCATCTACT	0.368	Melanoma(8;187 585 15745 40864 52829)		NA											62	93					4.96213e-28	9.10444e-28	0.00361	1	0
CDH9	1007	broad.mit.edu	37	5	26906079	26906079	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:26906079C>T	uc003jgs.1	-	5	969	c.800G>A	c.(799-801)CGA>CAA	p.R267Q	CDH9_uc010iug.2_Missense_Mutation_p.R267Q	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	267	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						CTGGGGAAATCGAGGAGGGTT	0.428	Melanoma(8;187 585 15745 40864 52829)		NA											22	377					0	0	0.002299	0	0
CDH9	1007	broad.mit.edu	37	5	26988490	26988490	+	Splice_Site	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:26988490C>T	uc003jgs.1	-	2	121	c.-48_splice	c.e2-1		CDH9_uc010iug.2_Splice_Site	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein						adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TTTGTTTTTCCTAAAGAGTAA	0.313	Melanoma(8;187 585 15745 40864 52829)		NA											13	48					0	0	0.001368	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33576335	33576335	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:33576335G>T	uc003jia.1	-	19	3959	c.3796C>A	c.(3796-3798)CGT>AGT	p.R1266S	ADAMTS12_uc010iuq.1_Missense_Mutation_p.R1181S	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1266	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						AGGTGGTTACGGTTTGCCGTC	0.498			NA								HNSCC(64;0.19)			40	505					6.97489e-18	1.23327e-17	0.004878	1	0
C5orf42	65250	broad.mit.edu	37	5	37201763	37201763	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:37201763C>T	uc011cpa.1	-	19	3668	c.3437G>A	c.(3436-3438)GGC>GAC	p.G1146D	C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.G221D|C5orf42_uc011cpb.1_Missense_Mutation_p.G27D	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	1146										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TGGCACTAAGCCCCACAGTCT	0.418			NA											8	203					0	0	0.004482	0	0
RICTOR	253260	broad.mit.edu	37	5	38959970	38959970	+	Silent	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:38959970G>A	uc003jlp.2	-	21	1986	c.1962C>T	c.(1960-1962)ACC>ACT	p.T654T	RICTOR_uc003jlo.2_Silent_p.T654T|RICTOR_uc010ivf.2_Silent_p.T369T	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	654					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					GTTGACTAAGGGTGGTCAATA	0.378			NA											18	201					0	0	0.007413	0	0
FYB	2533	broad.mit.edu	37	5	39202316	39202316	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:39202316G>T	uc003jls.2	-	1	814	c.747C>A	c.(745-747)GAC>GAA	p.D249E	FYB_uc003jlt.2_Missense_Mutation_p.D249E|FYB_uc003jlu.2_Missense_Mutation_p.D249E|FYB_uc011cpl.1_Missense_Mutation_p.D259E	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	249					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			CCCCTGCATGGTCTTTATTTT	0.493			NA											30	301					3.1745e-13	5.23296e-13	0.008361	1	0
PLCXD3	345557	broad.mit.edu	37	5	41382556	41382556	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:41382556C>A	uc003jmm.1	-	2	286	c.184G>T	c.(184-186)GTC>TTC	p.V62F		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	62	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						AACACAGAGACAAAATTCTGG	0.448			NA											30	192					5.45727e-16	9.28616e-16	0.008361	1	0
ITGA1	3672	broad.mit.edu	37	5	52145269	52145269	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:52145269A>T	uc003jou.2	+	2	184	c.132A>T	c.(130-132)GAA>GAT	p.E44D	ITGA1_uc003jov.2_RNA	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	44	Extracellular (Potential).|FG-GAP 1.				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				GCCCGGTGGAAGACATGTTTG	0.358			NA											17	147					0	0	0.004007	0	0
ITGA2	3673	broad.mit.edu	37	5	52369034	52369034	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:52369034C>A	uc003joy.2	+	20	2659	c.2516C>A	c.(2515-2517)ACT>AAT	p.T839N	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.T763N|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_Intron	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	839	Extracellular (Potential).				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				GCATACAACACTGGAATTGTT	0.363			NA											23	391					7.41877e-09	1.1426e-08	0.001882	1	0
CDC20B	166979	broad.mit.edu	37	5	54415705	54415705	+	Silent	SNP	T	T	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:54415705T>G	uc003jpo.1	-	11	1558	c.1383A>C	c.(1381-1383)GCA>GCC	p.A461A	CDC20B_uc003jpn.1_Silent_p.A461A|CDC20B_uc010ivu.1_Silent_p.A419A	NM_152623	NP_689836	Q86Y33	CD20B_HUMAN	CDC20 cell division cycle 20 homolog B isoform	461	WD 6.										0		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			CTTGACCAGTTGCAATCTCCT	0.393			NA											149	357					0	0	0.00361	0	0
DHX29	54505	broad.mit.edu	37	5	54573088	54573088	+	Nonsense_Mutation	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:54573088G>C	uc003jpx.2	-	13	2252	c.2132C>G	c.(2131-2133)TCA>TGA	p.S711*	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	711	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TAGGAAGTCTGACTGGACACT	0.338			NA											5	197					0	0	0.001168	0	0
MAP3K1	4214	broad.mit.edu	37	5	56160759	56160759	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:56160759C>T	uc003jqw.3	+	4	1534	c.1033C>T	c.(1033-1035)CAG>TAG	p.Q345*		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	345	SWIM-type.				cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		TATTGGGCCTCAGGTAGGATT	0.383			NA											6	66					0	0	0.001168	0	0
HAPLN1	1404	broad.mit.edu	37	5	82940367	82940367	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:82940367G>T	uc003kim.2	-	3	661	c.590C>A	c.(589-591)GCC>GAC	p.A197D	HAPLN1_uc003kin.2_Missense_Mutation_p.A197D	NM_001884	NP_001875	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	197	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			large_intestine(3)|ovary(1)|skin(1)	5		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		GCCCCGCCAGGCGTCGTACAG	0.612			NA											6	50					2.17888e-05	2.95972e-05	0.006214	1	0
WDR36	134430	broad.mit.edu	37	5	110459809	110459809	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:110459809A>G	uc003kpd.2	+	21	2557	c.2440A>G	c.(2440-2442)AAA>GAA	p.K814E	WDR36_uc010jbu.2_Intron	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36	814					response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		GTTTAAGTCTAAAGTGGTAAA	0.264			NA											10	89					0	0	0.000978	0	0
KCNN2	3781	broad.mit.edu	37	5	113698885	113698885	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:113698885C>T	uc003kqo.2	+	1	870	c.413C>T	c.(412-414)GCG>GTG	p.A138V		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	138	Helical; Name=Segment S1; (Potential).					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		AGCGACTACGCGCTCATCTTC	0.577			NA											4	25					0	0	0.000248	0	0
SNCAIP	9627	broad.mit.edu	37	5	121786248	121786248	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:121786248C>T	uc003ksw.1	+	10	1912	c.1706C>T	c.(1705-1707)TCC>TTC	p.S569F	SNCAIP_uc011cwl.1_Missense_Mutation_p.S127F|SNCAIP_uc003ksx.1_Missense_Mutation_p.S616F|SNCAIP_uc003ksy.1_Missense_Mutation_p.S203F|SNCAIP_uc003ksz.1_Missense_Mutation_p.S203F|SNCAIP_uc010jcu.2_Missense_Mutation_p.S165F|SNCAIP_uc011cwm.1_Missense_Mutation_p.S203F|SNCAIP_uc003kta.1_Missense_Mutation_p.S201F|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Missense_Mutation_p.S263F|SNCAIP_uc010jcx.1_Missense_Mutation_p.S509F|uc003ktb.1_RNA|SNCAIP_uc003ktc.1_Missense_Mutation_p.S85F	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	569					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		TCACCTGCCTCCAGAAAGTCC	0.453			NA											17	212					0	0	0.006122	0	0
CDKL3	51265	broad.mit.edu	37	5	133702187	133702187	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:133702187C>A	uc003kzf.3	-	2	147	c.28G>T	c.(28-30)GTG>TTG	p.V10L	CDKL3_uc011cxm.1_Intron|CDKL3_uc011cxn.1_Intron|CDKL3_uc010jdw.2_Intron|CDKL3_uc011cxo.1_Intron|CDKL3_uc011cxp.1_Intron|CDKL3_uc011cxq.1_Intron|CDKL3_uc003kzg.3_Missense_Mutation_p.V10L|CDKL3_uc011cxr.1_Missense_Mutation_p.V10L	NM_001113575	NP_001107047	Q8IVW4	CDKL3_HUMAN	cyclin-dependent kinase-like 3 isoform 1	10	ATP (By similarity).|Protein kinase.					cytoplasm	ATP binding|cyclin-dependent protein kinase activity			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCCTCTCCCACTTTTCCAAGG	0.338			NA											5	30					0.00198382	0.00247684	0.001984	1	0
DDX46	9879	broad.mit.edu	37	5	134147433	134147433	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:134147433C>T	uc003kzw.2	+	18	2502	c.2334C>T	c.(2332-2334)TTC>TTT	p.F778F	DDX46_uc003kzv.1_RNA	NM_014829	NP_055644	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	778					mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTAAGGGATTCAAGTTTGATG	0.353	Colon(13;391 453 4901 21675 24897)		NA											10	117					0	0	0.006214	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167047	140167048	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:140167047_140167048CC>AA	uc003lhb.2	+	1	1172_1173	c.1172_1173CC>AA	c.(1171-1173)CCC>CAA	p.P391Q	PCDHA1_uc003lha.2_Missense_Mutation_p.P391Q|PCDHA1_uc003lgz.2_Missense_Mutation_p.P391Q	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	391	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCTTAATGCCCCACGTCCCCT	0.584			NA											14	130					0	0	0.004672	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140306690	140306690	+	Silent	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:140306690C>A	uc003lih.2	+	1	389	c.213C>A	c.(211-213)CCC>CCA	p.P71P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Silent_p.P71P	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	71	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGATCTACCCAGCGGCAATT	0.637			NA											8	50					0.00307968	0.00382243	0.00308	1	0
PCDHB7	56129	broad.mit.edu	37	5	140554442	140554442	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:140554442G>T	uc003lit.2	+	1	2200	c.2026G>T	c.(2026-2028)GCG>TCG	p.A676S	PCDHB8_uc011dai.1_5'Flank	NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	676	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTCCCGGAGGCGGCCCCGGA	0.692			NA											19	184					1.56452e-12	2.55903e-12	0.007413	1	0
PCDHGA11	56105	broad.mit.edu	37	5	140801457	140801457	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:140801457C>T	uc003lkq.1	+	1	921	c.663C>T	c.(661-663)CCC>CCT	p.P221P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Silent_p.P221P|PCDHGA11_uc003lkp.1_Silent_p.P221P	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	221	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGGCGATCCCATCCGAAAGG	0.527			NA											7	77					0	0	0.001984	0	0
PCDHGC4	56098	broad.mit.edu	37	5	140866246	140866246	+	Silent	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:140866246A>G	uc003lky.1	+	1	1506	c.1506A>G	c.(1504-1506)GTA>GTG	p.V502V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc011dbb.1_Silent_p.V502V|PCDHGC5_uc011dbc.1_5'Flank|PCDHGC5_uc003lla.1_5'Flank	NM_018928	NP_061751	Q9Y5F7	PCDGL_HUMAN	protocadherin gamma subfamily C, 4 isoform 1	502	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCGAGATGTATCAGCTTCCT	0.537			NA											35	173					0	0	0.002836	0	0
GALNT10	55568	broad.mit.edu	37	5	153783750	153783750	+	Silent	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:153783750G>T	uc003lvh.2	+	8	1275	c.1143G>T	c.(1141-1143)CCG>CCT	p.P381P	GALNT10_uc010jic.2_RNA|GALNT10_uc010jid.2_Silent_p.P222P|uc003lvi.2_Intron|GALNT10_uc003lvj.2_Silent_p.P52P	NM_198321	NP_938080	Q86SR1	GLT10_HUMAN	GalNAc transferase 10 isoform a	381	Lumenal (Potential).|Flexible loop.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			ACAAGGTCCCGGCCGGAGTCA	0.627			NA											11	43					6.40141e-05	8.47718e-05	0.000978	1	0
GABRB2	2561	broad.mit.edu	37	5	160763718	160763718	+	Silent	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:160763718T>A	uc003lys.1	-	7	818	c.600A>T	c.(598-600)ACA>ACT	p.T200T	GABRB2_uc011deh.1_Silent_p.T39T|GABRB2_uc003lyr.1_Silent_p.T200T|GABRB2_uc003lyt.1_Silent_p.T200T|GABRB2_uc010jiu.1_Silent_p.T137T	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	200	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TCGTTACTCCTGTTACTGCAT	0.318			NA											19	89					0	0	0.006122	0	0
GABRG2	2566	broad.mit.edu	37	5	161524754	161524754	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:161524754G>T	uc003lyz.3	+	4	796	c.438G>T	c.(436-438)TGG>TGT	p.W146C	GABRG2_uc010jjc.2_Missense_Mutation_p.W146C|GABRG2_uc003lyy.3_Missense_Mutation_p.W146C|GABRG2_uc011dej.1_Missense_Mutation_p.W51C	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	146	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		GGAAAATCTGGATTCCAGACA	0.423			NA											19	68					3.57192e-18	6.33341e-18	0.006122	1	0
ODZ2	57451	broad.mit.edu	37	5	167645439	167645439	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:167645439G>T	uc010jjd.2	+	23	4516	c.4516G>T	c.(4516-4518)GGG>TGG	p.G1506W	ODZ2_uc003lzr.3_Missense_Mutation_p.G1276W|ODZ2_uc003lzt.3_Missense_Mutation_p.G879W|ODZ2_uc010jje.2_Missense_Mutation_p.G770W	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CCTTTTAGCTGGGGCAGCCTC	0.498			NA											39	173					4.14481e-20	7.41148e-20	0.00623	1	0
DOCK2	1794	broad.mit.edu	37	5	169423144	169423144	+	Silent	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:169423144A>G	uc003maf.2	+	30	3128	c.3048A>G	c.(3046-3048)CTA>CTG	p.L1016L	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.L508L	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1016	Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGAAGTTCCTAGAACACACGA	0.498			NA											3	76					0	0	0.004672	0	0
RANBP17	64901	broad.mit.edu	37	5	170305126	170305126	+	Missense_Mutation	SNP	G	G	T	rs147041695		TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:170305126G>T	uc003mba.2	+	2	60	c.44G>T	c.(43-45)TGT>TTT	p.C15F	RANBP17_uc003max.1_RNA|RANBP17_uc003may.1_RNA|RANBP17_uc003maz.1_RNA|RANBP17_uc010jjr.1_RNA|RANBP17_uc003maw.2_Missense_Mutation_p.C15F|RANBP17_uc011dew.1_Missense_Mutation_p.C15F	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	15					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GAAGTGTTATGTACTCATCTC	0.338			NA	T	TRD@	ALL								9	46					3.09899e-07	4.56199e-07	0.004482	1	0
LOC202181	202181	broad.mit.edu	37	5	177054515	177054515	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:177054515A>G	uc011dgc.1	-	2	358	c.230T>C	c.(229-231)ATG>ACG	p.M77T	LOC202181_uc011dgb.1_RNA	NM_198567	NP_940969			hypothetical protein LOC375484												0						CACAAAGTCCATCAAAAACTG	0.443			NA											20	94					0	0	0.002299	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178581891	178581891	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:178581891G>A	uc003mjw.2	-	7	1162	c.1162C>T	c.(1162-1164)CCG>TCG	p.P388S	ADAMTS2_uc011dgm.1_Missense_Mutation_p.P388S	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	388	Peptidase M12B.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CTGCGGACCGGATGGCACATG	0.637			NA											4	21					0	0	0.001984	0	0
MAML1	9794	broad.mit.edu	37	5	179192504	179192504	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr5:179192504G>T	uc003mkm.2	+	2	756	c.493G>T	c.(493-495)GAC>TAC	p.D165Y	MAML1_uc003mkn.1_Missense_Mutation_p.D165Y	NM_014757	NP_055572	Q92585	MAML1_HUMAN	mastermind-like 1	165					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			lung(4)|ovary(2)	6	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGGTCAGTCTGACAAGCCTTC	0.597			NA											12	58					3.07112e-06	4.28198e-06	0.000978	1	0
SERPINB9	5272	broad.mit.edu	37	6	2890614	2890614	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:2890614G>A	uc003mug.2	-	7	1035	c.914C>T	c.(913-915)GCG>GTG	p.A305V	uc003mue.2_Intron|SERPINB9_uc003muf.2_Missense_Mutation_p.A108V	NM_004155	NP_004146	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B, member 9	305					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.108)				GTCTCTCTCCGCTGACATTGC	0.498			NA											16	103					0	0	0.003163	0	0
LRRC16A	55604	broad.mit.edu	37	6	25600607	25600607	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:25600607G>T	uc011djw.1	+	33	3561	c.3185G>T	c.(3184-3186)CGA>CTA	p.R1062L	LRRC16A_uc010jpx.2_Missense_Mutation_p.R1062L|LRRC16A_uc010jpy.2_Missense_Mutation_p.R1062L	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1062	Inhibits capping activity of CAPZA2 (By similarity).				actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						AAGAAAAAGCGAGATTCTCGG	0.438			NA											17	85					2.48551e-13	4.1079e-13	0.00499	1	0
HIST1H3E	8353	broad.mit.edu	37	6	26225732	26225732	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:26225732G>A	uc003nhb.2	+	2	710	c.350G>A	c.(349-351)CGC>CAC	p.R117H	HIST1H3E_uc003nhc.3_Missense_Mutation_p.R117H	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	117					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0223)|Acute lymphoblastic leukemia(11;0.0351)				CATGCCAAACGCGTGACCATC	0.557			NA									OREG0017240	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	98					0	0	0.004482	0	0
HIST1H4I	8294	broad.mit.edu	37	6	27107277	27107277	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:27107277G>A	uc003niy.1	+	1	190	c.190G>A	c.(190-192)GAG>AAG	p.E64K	HIST1H2BK_uc003nix.1_Intron	NM_003495	NP_003486	P62805	H4_HUMAN	histone cluster 1, H4i	64			E -> Q (in a breast cancer sample; somatic mutation).		CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			lung(1)	1						GGTGTTCCTGGAGAACGTGAT	0.652			NA	T	BCL6	NHL								17	57					0	0	0.004007	0	0
HIST1H4I	8294	broad.mit.edu	37	6	27107279	27107279	+	Silent	SNP	G	G	A	rs150377743	byFrequency	TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:27107279G>A	uc003niy.1	+	1	192	c.192G>A	c.(190-192)GAG>GAA	p.E64E	HIST1H2BK_uc003nix.1_Intron	NM_003495	NP_003486	P62805	H4_HUMAN	histone cluster 1, H4i	64			E -> Q (in a breast cancer sample; somatic mutation).		CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			lung(1)	1						TGTTCCTGGAGAACGTGATCC	0.657			NA	T	BCL6	NHL								17	60					0	0	0.004007	0	0
GPX6	257202	broad.mit.edu	37	6	28483474	28483474	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:28483474A>G	uc011dlj.1	-	1	97	c.47T>C	c.(46-48)GTT>GCT	p.V16A	GPX6_uc010jrg.1_RNA	NM_182701	NP_874360	P59796	GPX6_HUMAN	glutathione peroxidase 6 precursor	16					response to oxidative stress	extracellular region	glutathione peroxidase activity			ovary(3)|pancreas(1)|skin(1)	5					Glutathione(DB00143)	AGCAAAGCCAACCAGGAAAAA	0.542			NA											5	36					0	0	0.001984	0	0
OR12D2	26529	broad.mit.edu	37	6	29365221	29365221	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:29365221C>G	uc003nmf.3	+	1	806	c.745C>G	c.(745-747)CTT>GTT	p.L249V		NM_013936	NP_039224	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D,	249	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGTAGTTATTCTTTTCTATGC	0.443			NA											33	181					0	0	0.003271	0	0
DDR1	780	broad.mit.edu	37	6	30862315	30862315	+	Silent	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:30862315G>A	uc003nrr.2	+	12	1639	c.1380G>A	c.(1378-1380)ACG>ACA	p.T460T	DDR1_uc010jse.2_Silent_p.T460T|DDR1_uc003nrq.2_Silent_p.T460T|DDR1_uc003nrs.2_Silent_p.T460T|DDR1_uc003nrt.2_Silent_p.T460T|DDR1_uc011dms.1_Silent_p.T478T|DDR1_uc003nru.2_Silent_p.T460T|DDR1_uc003nrv.2_Silent_p.T460T|DDR1_uc003nrw.1_Intron|DDR1_uc003nry.1_RNA|DDR1_uc003nrx.1_Intron|DDR1_uc003nrz.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	460	Cytoplasmic (Potential).				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	AGGAGCTGACGGTTCACCTCT	0.552			NA											5	60					0	0	0.000602	0	0
POU5F1	5460	broad.mit.edu	37	6	31133041	31133041	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:31133041A>G	uc003nsv.2	-	4	734	c.680T>C	c.(679-681)GTG>GCG	p.V227A	POU5F1_uc003nsu.2_Missense_Mutation_p.V132A|uc011dnf.1_5'Flank	NM_002701	NP_002692	Q01860	PO5F1_HUMAN	POU domain, class 5, transcription factor 1	227				V -> L (in Ref. 7; CAA79974).	anatomical structure morphogenesis|blastocyst development|BMP signaling pathway involved in heart induction|cardiac cell fate determination|cell fate commitment involved in formation of primary germ layers|mRNA transcription from RNA polymerase II promoter|negative regulation of gene silencing by miRNA|positive regulation of catenin import into nucleus|positive regulation of SMAD protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|regulation of asymmetric cell division|regulation of heart induction by regulation of canonical Wnt receptor signaling pathway|regulation of methylation-dependent chromatin silencing|response to wounding|somatic stem cell maintenance|somatic stem cell maintenance	cytosol|nucleoplasm|transcription factor complex	miRNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding		EWSR1/POU5F1(10)	skin(7)|salivary_gland(2)|bone(2)|lung(1)|ovary(1)	13						TCGGGCCTGCACGAGGGTTTC	0.537			NA	T	EWSR1	sarcoma								4	15					0	0	0.00308	0	0
EHMT2	10919	broad.mit.edu	37	6	31857313	31857313	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:31857313C>G	uc003nxz.1	-	8	941	c.931G>C	c.(931-933)GAA>CAA	p.E311Q	EHMT2_uc003nxy.1_Missense_Mutation_p.E102Q|EHMT2_uc011don.1_Missense_Mutation_p.E368Q|EHMT2_uc003nya.1_Missense_Mutation_p.E311Q	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	311	Poly-Glu.				DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						tcttcctcttcttcttcttcc	0.289			NA											3	71					0	0	0.004672	0	0
C6orf10	10665	broad.mit.edu	37	6	32261492	32261493	+	Missense_Mutation	DNP	CC	CC	TT			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:32261492_32261493CC>TT	uc011dpy.1	-	12	1130_1131	c.957_958GG>AA	c.(955-960)CAGGGA>CAAAGA	p.G320R	C6orf10_uc011dpx.1_Missense_Mutation_p.G102R	NM_006781	NP_006772	Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	320						integral to membrane				skin(1)	1						ATTTGGGCTCCCTGTCCTTGTG	0.441			NA											39	202					0	0	0.004672	0	0
SRPK1	6732	broad.mit.edu	37	6	35837307	35837307	+	Missense_Mutation	SNP	A	A	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:35837307A>C	uc003olj.2	-	11	1486	c.1363T>G	c.(1363-1365)TGT>GGT	p.C455G	SRPK1_uc011dtg.1_Missense_Mutation_p.C439G|SRPK1_uc003olh.2_Missense_Mutation_p.C348G|SRPK1_uc003oli.2_Missense_Mutation_p.C348G	NM_003137	NP_003128	Q96SB4	SRPK1_HUMAN	SFRS protein kinase 1	455	Protein kinase.				cell differentiation|chromosome segregation|interspecies interaction between organisms|intracellular protein kinase cascade|mRNA processing|negative regulation of viral genome replication|positive regulation of viral genome replication|regulation of mRNA processing|RNA splicing	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1						TCATCTTCACAGGGTATCTCT	0.463	NSCLC(31;67 978 16289 24856 26454)		NA											14	149					0	0	0.00245	0	0
MAPK14	1432	broad.mit.edu	37	6	36075268	36075268	+	Nonsense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:36075268C>G	uc003olp.2	+	11	1359	c.878C>G	c.(877-879)TCA>TGA	p.S293*	MAPK14_uc003olq.2_Nonsense_Mutation_p.S293*|MAPK14_uc003olr.2_Missense_Mutation_p.Q267E|MAPK14_uc011dti.1_Nonsense_Mutation_p.S216*	NM_001315	NP_001306	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14 isoform 1	293	Protein kinase.				activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			ovary(2)|stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	6						GTATTGGACTCAGATAAGAGA	0.438	Pancreas(20;8 363 26997 32430 36377 43317 49243 50560 51947)|Colon(176;951 1093 20177 30266 32328 34418 35271 44052 51610)		NA											7	151					0	0	0.00308	0	0
TREM1	54210	broad.mit.edu	37	6	41250404	41250404	+	Silent	SNP	T	T	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:41250404T>C	uc003oqf.1	-	2	199	c.135A>G	c.(133-135)CTA>CTG	p.L45L	TREM1_uc003oqg.1_Silent_p.L45L	NM_018643	NP_061113	Q9NP99	TREM1_HUMAN	triggering receptor expressed on myeloid cells 1	45	Extracellular (Potential).|Ig-like V-type.				blood coagulation|humoral immune response|intracellular signal transduction|leukocyte migration	extracellular region|integral to membrane|intracellular|plasma membrane	receptor activity			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)				Glutathione(DB00143)	CAAACTTCTCTAGCGTGTAGT	0.478			NA											17	148					0	0	0.00499	0	0
PPP2R5D	5528	broad.mit.edu	37	6	42957397	42957397	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:42957397A>T	uc003oth.2	+	2	162	c.76A>T	c.(76-78)AAG>TAG	p.K26*	MEA1_uc010jyc.1_Intron|PPP2R5D_uc003otg.2_Nonsense_Mutation_p.K26*|PPP2R5D_uc010jyd.2_Intron|PPP2R5D_uc011dva.1_Intron|PPP2R5D_uc003oti.2_5'UTR	NM_006245	NP_006236	Q14738	2A5D_HUMAN	delta isoform of regulatory subunit B56, protein	26					nervous system development|signal transduction	cytoplasm|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			breast(1)|central_nervous_system(1)	2			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CAGCTCGGGCAAGGATGGTGG	0.537	Melanoma(63;587 1613 29742 31770)		NA											5	21					0	0	0.000602	0	0
MAD2L1BP	9587	broad.mit.edu	37	6	43604174	43604174	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:43604174G>C	uc003ovv.2	+	2	139	c.103G>C	c.(103-105)GAG>CAG	p.E35Q	MAD2L1BP_uc003ovu.2_Missense_Mutation_p.E67Q	NM_014628	NP_055443	Q15013	MD2BP_HUMAN	MAD2L1 binding protein isoform 2	35					mitotic cell cycle checkpoint|regulation of exit from mitosis	cytoplasm|nucleus|spindle	protein binding				0	all_cancers(18;9.36e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000351)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			AGAACTACTTGAGACAAGCTC	0.488			NA											4	68					0	0	0.000602	0	0
PKHD1	5314	broad.mit.edu	37	6	51890383	51890383	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:51890383C>A	uc003pah.1	-	32	4501	c.4225G>T	c.(4225-4227)GTG>TTG	p.V1409L	PKHD1_uc003pai.2_Missense_Mutation_p.V1409L	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1409	IPT/TIG 9.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					AACCCCCTCACAGTAAGTATG	0.498			NA											29	117					8.58068e-18	1.51297e-17	0.007291	1	0
MCM3	4172	broad.mit.edu	37	6	52149468	52149468	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:52149468G>A	uc003pan.1	-	1	115	c.5C>T	c.(4-6)GCG>GTG	p.A2V	MCM3_uc011dwu.1_5'UTR	NM_002388	NP_002379	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	2					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)|lung(1)|skin(1)	3	Lung NSC(77;0.0931)					CACGGTACCCGCCATGCCCGC	0.647			NA											4	7					0	0	0.000602	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62757886	62757886	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:62757886C>A	uc003peg.2	-	3	480	c.233G>T	c.(232-234)GGG>GTG	p.G78V		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	78	KH.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		AAGCAATTTCCCCACAAAATT	0.363			NA											10	69					0.000442599	0.000568287	0.006214	1	0
EPB41L2	2037	broad.mit.edu	37	6	131277563	131277563	+	Silent	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:131277563A>G	uc003qch.2	-	2	245	c.63T>C	c.(61-63)GAT>GAC	p.D21D	EPB41L2_uc003qcg.1_Silent_p.D21D|EPB41L2_uc011eby.1_Silent_p.D21D|EPB41L2_uc003qci.2_Silent_p.D21D|EPB41L2_uc010kfk.2_Silent_p.D21D|EPB41L2_uc010kfl.1_Silent_p.D21D	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	21					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CCTTGGTTGCATCTGTTCCTA	0.438			NA											5	76					0	0	0.000602	0	0
BCLAF1	9774	broad.mit.edu	37	6	136582513	136582513	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:136582513T>A	uc003qgx.1	-	12	2900	c.2647A>T	c.(2647-2649)AGC>TGC	p.S883C	BCLAF1_uc011edb.1_Missense_Mutation_p.S162C|BCLAF1_uc003qgw.1_Missense_Mutation_p.S710C|BCLAF1_uc003qgy.1_Missense_Mutation_p.S832C|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.S881C	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	883					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TTAGGACTGCTACCTGATTTT	0.433	Colon(142;1534 1789 5427 7063 28491)		NA											37	348					0	0	0.005524	0	0
BCLAF1	9774	broad.mit.edu	37	6	136589341	136589341	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:136589341A>G	uc003qgx.1	-	10	2609	c.2356T>C	c.(2356-2358)TAC>CAC	p.Y786H	BCLAF1_uc011edb.1_Missense_Mutation_p.Y114H|BCLAF1_uc003qgw.1_Missense_Mutation_p.Y613H|BCLAF1_uc003qgy.1_Missense_Mutation_p.Y784H|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.Y784H	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	786					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AAGCCTGAGTATTCTTTCATT	0.383	Colon(142;1534 1789 5427 7063 28491)		NA											9	174					0	0	0.008291	0	0
MIOS	54468	broad.mit.edu	37	7	7636007	7636007	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:7636007C>T	uc003srf.2	+	11	2624	c.2316C>T	c.(2314-2316)GTC>GTT	p.V772V	MIOS_uc003srg.2_Silent_p.V307V|MIOS_uc010ktq.2_Silent_p.V167V	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	772											0						AATCTAAAGTCACAAGTTGTC	0.458			NA											15	133					0	0	0.00499	0	0
DGKB	1607	broad.mit.edu	37	7	14217662	14217662	+	Missense_Mutation	SNP	A	A	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:14217662A>C	uc003ssz.2	-	23	2427	c.2240T>G	c.(2239-2241)GTC>GGC	p.V747G	DGKB_uc011jxt.1_Missense_Mutation_p.V728G|DGKB_uc003sta.2_Missense_Mutation_p.V747G|DGKB_uc011jxu.1_Missense_Mutation_p.V746G	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	747					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	CTACCTGATGACCACGCAGGA	0.498			NA											12	76					0	0	0.001368	0	0
CLK2P	1197	broad.mit.edu	37	7	23625596	23625596	+	Translation_Start_Site	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:23625596G>C	uc003swk.2	-	1	551	c.-99C>G	c.(-101--97)ATCAT>ATGAT			NR_002711				SubName: Full=cDNA FLJ61616, highly similar to Dual specificity protein kinase CLK2 (EC 2.7.12.1); SubName: Full=CDC-like kinase 2, isoform CRA_c; SubName: Full=Putative uncharacterized protein CLK2;												0						CATTCTTAATGATCTTCAGGG	0.493			NA											9	47					0	0	0.008291	0	0
AEBP1	165	broad.mit.edu	37	7	44149642	44149642	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:44149642C>A	uc003tkb.2	+	10	1484	c.1179C>A	c.(1177-1179)CAC>CAA	p.H393Q	AEBP1_uc003tkc.3_5'Flank|AEBP1_uc003tkd.2_5'Flank	NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	393	Required for DNA-binding and interaction with NFKBIA (By similarity).|F5/8 type C.				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGGAGTCACACCGTATTGAGG	0.627			NA											8	33					3.07112e-06	4.28198e-06	0.000978	1	0
PKD1L1	168507	broad.mit.edu	37	7	47970755	47970755	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:47970755C>A	uc003tny.1	-	6	683	c.683G>T	c.(682-684)AGC>ATC	p.S228I		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	228	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						TCGCTGGGAGCTGGTCTGAGT	0.612			NA											9	50					0.00448238	0.00553089	0.004482	1	0
ZPBP	11055	broad.mit.edu	37	7	50070835	50070835	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:50070835T>A	uc003tou.2	-	5	629	c.559A>T	c.(559-561)AAT>TAT	p.N187Y	ZPBP_uc011kci.1_Missense_Mutation_p.N113Y|ZPBP_uc010kyw.2_Missense_Mutation_p.N186Y	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	187					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					AAAGAAATATTATAAATGCTA	0.343			NA											10	73					0	0	0.000978	0	0
LANCL2	55915	broad.mit.edu	37	7	55496113	55496113	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:55496113C>G	uc003tqp.2	+	8	1809	c.1231C>G	c.(1231-1233)CCT>GCT	p.P411A		NM_018697	NP_061167	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2	411					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			ovary(1)|skin(1)	2	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			GTGCCGCATTCCTGACAGACC	0.443			NA											11	56					0	0	0.001368	0	0
PION	54103	broad.mit.edu	37	7	76984630	76984630	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:76984630A>G	uc003ugf.2	-	16	1317	c.1238T>C	c.(1237-1239)TTA>TCA	p.L413S	PION_uc003ugg.1_Missense_Mutation_p.L198S	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	413					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						AAGCTGTAATAAAGACGACTG	0.507			NA											16	121					0	0	0.007413	0	0
SAMD9L	219285	broad.mit.edu	37	7	92764239	92764239	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:92764239G>A	uc003umh.1	-	5	2262	c.1046C>T	c.(1045-1047)TCT>TTT	p.S349F	SAMD9L_uc003umj.1_Missense_Mutation_p.S349F|SAMD9L_uc003umi.1_Missense_Mutation_p.S349F|SAMD9L_uc010lfb.1_Missense_Mutation_p.S349F|SAMD9L_uc003umk.1_Missense_Mutation_p.S349F|SAMD9L_uc010lfc.1_Missense_Mutation_p.S349F|SAMD9L_uc010lfd.1_Missense_Mutation_p.S349F|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	349										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			GATATCCCTAGAGCTAGCCCC	0.348			NA											6	211					0	0	0.001168	0	0
CDHR3	222256	broad.mit.edu	37	7	105662817	105662817	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:105662817C>G	uc003vdl.3	+	14	2107	c.1999C>G	c.(1999-2001)CTT>GTT	p.L667V	CDHR3_uc003vdk.2_Intron|CDHR3_uc003vdm.3_Missense_Mutation_p.L654V|CDHR3_uc011klt.1_Missense_Mutation_p.L579V|CDHR3_uc003vdn.2_Intron	NM_152750	NP_689963	Q6ZTQ4	CDHR3_HUMAN	hypothetical protein LOC222256 precursor	667	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						AGCGGAGGCTCTTGTTGAGAC	0.473			NA											14	180					0	0	0.00245	0	0
HYAL4	23553	broad.mit.edu	37	7	123508376	123508376	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:123508376G>T	uc003vlc.2	+	3	687	c.49G>T	c.(49-51)GTA>TTA	p.V17L	HYAL4_uc011knz.1_Missense_Mutation_p.V17L	NM_012269	NP_036401	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	17	Helical; (Potential).				fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			skin(1)	1						TGTTCAACCAGTACATCTCAC	0.343			NA											24	157					6.36457e-07	9.28289e-07	0.003954	1	0
AKR1B10	57016	broad.mit.edu	37	7	134222989	134222989	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:134222989C>A	uc003vrr.2	+	8	1105	c.785C>A	c.(784-786)CCC>CAC	p.P262H		NM_020299	NP_064695	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10	262	NADP.				cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			skin(5)	5						ATTGTCATCCCCAAGTCTGTG	0.522			NA											45	222					1.51926e-22	2.73207e-22	0.00361	1	0
KIAA1549	57670	broad.mit.edu	37	7	138556069	138556069	+	Nonsense_Mutation	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:138556069G>C	uc011kql.1	-	13	4434	c.4385C>G	c.(4384-4386)TCA>TGA	p.S1462*	KIAA1549_uc011kqi.1_Nonsense_Mutation_p.S246*|KIAA1549_uc003vuk.3_Nonsense_Mutation_p.S1412*|KIAA1549_uc011kqj.1_Nonsense_Mutation_p.S1462*|KIAA1549_uc011kqk.1_Nonsense_Mutation_p.S246*	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	1462						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						GATGGAGGCTGATGAGTGCTG	0.562	NSCLC(119;1534 1718 44213 46230 50068)		NA	O	BRAF	pilocytic astrocytoma								7	73					0	0	0.001984	0	0
TAS2R3	50831	broad.mit.edu	37	7	141464496	141464496	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:141464496C>G	uc003vwp.1	+	1	600	c.538C>G	c.(538-540)CTG>GTG	p.L180V		NM_016943	NP_058639	Q9NYW6	TA2R3_HUMAN	taste receptor T2R3	180	Extracellular (Potential).				sensory perception of taste		taste receptor activity			central_nervous_system(1)	1	Melanoma(164;0.0171)					TGAGTATTATCTGATCCATGT	0.478			NA											17	53					0	0	0.006122	0	0
EPHB6	2051	broad.mit.edu	37	7	142563293	142563293	+	Missense_Mutation	SNP	G	G	A	rs143088751		TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:142563293G>A	uc011kst.1	+	8	1797	c.1010G>A	c.(1009-1011)CGC>CAC	p.R337H	EPHB6_uc011ksu.1_Missense_Mutation_p.R337H|EPHB6_uc003wbs.2_Missense_Mutation_p.R45H|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_Missense_Mutation_p.R45H|EPHB6_uc003wbv.2_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	337	Extracellular (Potential).|Cys-rich.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					TGCCCTGCCCGCAGTCACGCT	0.667			NA											10	35					0	0	0.000978	0	0
TAS2R39	259285	broad.mit.edu	37	7	142881181	142881181	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:142881181T>C	uc011ksw.1	+	1	670	c.670T>C	c.(670-672)TTC>CTC	p.F224L		NM_176881	NP_795362	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	224	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1	Melanoma(164;0.059)					TCTGATCATGTTCATCCTGAC	0.507			NA											22	123					0	0	0.002299	0	0
SSPO	23145	broad.mit.edu	37	7	149492429	149492429	+	Silent	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:149492429A>T	uc010lpk.2	+	43	6318	c.6318A>T	c.(6316-6318)GGA>GGT	p.G2106G		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2106	F5/8 type C.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCCCTCAGGGATGGCACGCTG	0.657			NA											4	31					0	0	0.000248	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417566	150417566	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:150417566C>T	uc003whq.2	+	3	561	c.474C>T	c.(472-474)GCC>GCT	p.A158A	GIMAP1_uc003whp.2_Silent_p.A166A	NM_130759	NP_570115	Q8WWP7	GIMA1_HUMAN	GTPase, IMAP family member 1	158	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGGACCTGGCCGGGGGCTCCC	0.647			NA											9	76					0	0	0.004482	0	0
MLL3	58508	broad.mit.edu	37	7	151876995	151876995	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:151876995C>T	uc003wla.2	-	37	7585	c.7366G>A	c.(7366-7368)GCT>ACT	p.A2456T	MLL3_uc003wkz.2_Missense_Mutation_p.A1517T|MLL3_uc003wky.2_5'Flank	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2456	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GGGAAAACAGCATATCTAGGT	0.488	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								16	104					0	0	0.004007	0	0
C8orf74	203076	broad.mit.edu	37	8	10555137	10555137	+	Silent	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr8:10555137C>A	uc003wtd.1	+	3	299	c.270C>A	c.(268-270)ATC>ATA	p.I90I	C8orf74_uc003wte.1_RNA	NM_001040032	NP_001035121	Q6P047	CH074_HUMAN	hypothetical protein LOC203076	90											0				COAD - Colon adenocarcinoma(149;0.0811)		CTGTGACGATCCTGGGGAACA	0.582			NA											12	97					2.80697e-09	4.37639e-09	0.000978	1	0
PIWIL2	55124	broad.mit.edu	37	8	22161574	22161574	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr8:22161574G>A	uc003xbn.2	+	11	1370	c.1222G>A	c.(1222-1224)GAG>AAG	p.E408K	PIWIL2_uc011kzf.1_Missense_Mutation_p.E408K|PIWIL2_uc010ltv.2_Missense_Mutation_p.E408K	NM_018068	NP_060538	Q8TC59	PIWL2_HUMAN	piwi-like 2	408	PAZ.				DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			skin(1)	1				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		CTTCCAGGATGAGTGTACTAA	0.378			NA											6	69					0	0	0.001984	0	0
CSPP1	79848	broad.mit.edu	37	8	68070788	68070788	+	Missense_Mutation	SNP	A	A	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr8:68070788A>C	uc003xxi.2	+	20	2469	c.2438A>C	c.(2437-2439)GAG>GCG	p.E813A	CSPP1_uc003xxg.1_Missense_Mutation_p.E805A|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.E778A|CSPP1_uc003xxk.2_Missense_Mutation_p.E433A	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	813	Glu-rich.					centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			ATTCagcaggagtatgaagag	0.299			NA											5	16					0	0	0.001168	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885671	88885671	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr8:88885671G>T	uc003ydz.2	-	1	626	c.529C>A	c.(529-531)CTT>ATT	p.L177I		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	177										ovary(1)	1						AAACTGCAAAGCATGCCAGGC	0.572			NA											11	117					0.00010058	0.000132089	0.001368	1	0
KIAA1429	25962	broad.mit.edu	37	8	95507124	95507124	+	Silent	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr8:95507124T>A	uc003ygo.1	-	20	4618	c.4605A>T	c.(4603-4605)CCA>CCT	p.P1535P	KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1535					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			CAGCCTGAAATGGAGTGAACC	0.323			NA											41	156					0	0	0.002222	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110520333	110520333	+	Missense_Mutation	SNP	T	T	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr8:110520333T>G	uc003yne.2	+	70	11339	c.11235T>G	c.(11233-11235)ATT>ATG	p.I3745M		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3745	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TAGGAATTATTAGAGATTCAA	0.333			NA								HNSCC(38;0.096)			6	91					0	0	0.00308	0	0
CSMD3	114788	broad.mit.edu	37	8	113299475	113299475	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr8:113299475C>A	uc003ynu.2	-	58	9308	c.9149G>T	c.(9148-9150)GGT>GTT	p.G3050V	CSMD3_uc003yns.2_Missense_Mutation_p.G2252V|CSMD3_uc003ynt.2_Missense_Mutation_p.G3010V|CSMD3_uc011lhx.1_Missense_Mutation_p.G2881V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3050	Sushi 21.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGTAGCATCACCTGCAATGCA	0.438			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			7	89					0.00198382	0.00247684	0.001984	1	0
ADCY8	114	broad.mit.edu	37	8	131826459	131826459	+	Silent	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr8:131826459G>T	uc003ytd.3	-	14	3025	c.2769C>A	c.(2767-2769)GCC>GCA	p.A923A	ADCY8_uc010mds.2_Silent_p.A792A	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	923	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AGTCCAGGCGGGCTGTGTACT	0.507			NA								HNSCC(32;0.087)			29	69					2.12542e-12	3.4675e-12	0.00632	1	0
TRAPPC9	83696	broad.mit.edu	37	8	141262908	141262908	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr8:141262908C>A	uc003yvj.2	-	16	2533	c.2399G>T	c.(2398-2400)TGC>TTC	p.C800F	TRAPPC9_uc003yvh.2_Missense_Mutation_p.C898F|TRAPPC9_uc010mel.1_Missense_Mutation_p.C221F|TRAPPC9_uc003yvi.1_Missense_Mutation_p.C791F	NM_001160372	NP_001153844	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9 isoform	800					cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2						ATTCTCCTGGCAGGAGAAATC	0.498			NA											27	46					1.75199e-13	2.91844e-13	0.007291	1	0
FAM154A	158297	broad.mit.edu	37	9	18950803	18950803	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr9:18950803C>T	uc003zni.1	-	2	449	c.171G>A	c.(169-171)CGG>CGA	p.R57R	FAM154A_uc010mip.1_5'UTR	NM_153707	NP_714918	Q8IYX7	F154A_HUMAN	hypothetical protein LOC158297	57										pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.53e-16)		TCTGGTACTCCCGCCTTGGCT	0.443			NA											28	115					0	0	0.008361	0	0
PRUNE2	158471	broad.mit.edu	37	9	79318919	79318919	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr9:79318919G>T	uc010mpk.2	-	9	7734	c.7610C>A	c.(7609-7611)ACA>AAA	p.T2537K	PRUNE2_uc004akj.3_5'UTR|PRUNE2_uc010mpl.1_5'UTR	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2537					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						ATTCTTCTCTGTACATCTTTC	0.383			NA											48	255					3.21987e-24	5.85683e-24	0.00361	1	0
TLR4	7099	broad.mit.edu	37	9	120475379	120475379	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr9:120475379G>T	uc004bjz.2	+	3	1264	c.973G>T	c.(973-975)GAC>TAC	p.D325Y	TLR4_uc004bka.2_Missense_Mutation_p.D285Y|TLR4_uc004bkb.2_Missense_Mutation_p.D125Y	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	325	Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						AAGGGTAAAAGACTTTTCTTA	0.313			NA											16	67					6.31663e-08	9.56561e-08	0.003163	1	0
RABEPK	10244	broad.mit.edu	37	9	127990243	127990243	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr9:127990243A>G	uc004bpi.2	+	7	754	c.581A>G	c.(580-582)CAT>CGT	p.H194R	RABEPK_uc004bpj.2_Missense_Mutation_p.H143R|RABEPK_uc004bpk.2_Missense_Mutation_p.H194R|RABEPK_uc004bpl.1_Missense_Mutation_p.H143R|RABEPK_uc004bpm.2_Missense_Mutation_p.H194R	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	194	Kelch 3.				receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						TCTCCCCGGCATGGTCATGTG	0.458			NA											18	52					0	0	0.008871	0	0
CIZ1	25792	broad.mit.edu	37	9	130941408	130941408	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr9:130941408G>A	uc004btt.2	-	8	1241	c.1078C>T	c.(1078-1080)CAG>TAG	p.Q360*	CIZ1_uc004btr.2_Nonsense_Mutation_p.Q360*|CIZ1_uc004bts.2_Nonsense_Mutation_p.Q331*|CIZ1_uc011maq.1_Nonsense_Mutation_p.Q355*|CIZ1_uc004btu.2_Nonsense_Mutation_p.Q336*|CIZ1_uc011mar.1_Nonsense_Mutation_p.Q259*|CIZ1_uc011mas.1_Nonsense_Mutation_p.Q390*|CIZ1_uc004btw.2_Nonsense_Mutation_p.Q360*|CIZ1_uc004btv.2_Nonsense_Mutation_p.Q360*|CIZ1_uc004btx.2_Nonsense_Mutation_p.Q336*	NM_001131016	NP_001124488	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1 isoform	360	Gln-rich.					nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4						ggctgcacctgcttctgttgc	0.249			NA											12	34					0	0	0.001368	0	0
TUBBP5	643224	broad.mit.edu	37	9	141071340	141071340	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr9:141071340G>A	uc004com.2	+	4	1004	c.743G>A	c.(742-744)CGC>CAC	p.R248H	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						TTCCAGGGTCGCATGCCCATG	0.542			NA											4	78					0	0	0.004482	0	0
IL3RA	3563	broad.mit.edu	37	X	1460679	1460679	+	Silent	SNP	G	G	T	rs138038721	byFrequency	TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:1460679G>T	uc004cps.2	+	2	370	c.21G>T	c.(19-21)ACG>ACT	p.T7T	IL3RA_uc011mhd.1_Silent_p.T7T	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	7						integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	TTTGGCTCACGCTGCTCCTGA	0.607			NA											14	145					2.62699e-14	4.42256e-14	0.003163	1	0
ASB11	140456	broad.mit.edu	37	X	15311352	15311352	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:15311352C>T	uc004cwp.1	-	4	460	c.460G>A	c.(460-462)GGA>AGA	p.G154R	ASB11_uc004cwo.1_Missense_Mutation_p.G133R|ASB11_uc010nes.1_RNA|ASB11_uc010net.1_Missense_Mutation_p.G137R	NM_080873	NP_543149	Q8WXH4	ASB11_HUMAN	ankyrin repeat and SOCS box-containing protein	154	ANK 3.				intracellular signal transduction					breast(2)|skin(1)	3	Hepatocellular(33;0.183)					GCCTTGGCTCCGAACTCCAGC	0.552			NA											31	166					0	0	0.002445	0	0
PPEF1	5475	broad.mit.edu	37	X	18802079	18802079	+	Silent	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:18802079A>T	uc004cyq.2	+	12	1306	c.825A>T	c.(823-825)ACA>ACT	p.T275T	PPEF1_uc004cyp.2_Silent_p.T275T|PPEF1_uc004cyr.2_Silent_p.T275T|PPEF1_uc004cys.2_Silent_p.T275T|PPEF1_uc011mja.1_Silent_p.T210T|PPEF1_uc011mjb.1_Silent_p.T219T	NM_006240	NP_006231	O14829	PPE1_HUMAN	protein phosphatase with EF hand calcium-binding	275	Catalytic.				detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity				0	Hepatocellular(33;0.183)					CAATCGGTACAATCGTTGACA	0.403			NA											35	122					0	0	0.003755	0	0
GPR64	10149	broad.mit.edu	37	X	19020988	19020988	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:19020988G>T	uc004cyx.2	-	24	2370	c.2206C>A	c.(2206-2208)CTT>ATT	p.L736I	GPR64_uc004cyy.2_Missense_Mutation_p.L733I|GPR64_uc004cyz.2_Missense_Mutation_p.L722I|GPR64_uc004czb.2_Missense_Mutation_p.L736I|GPR64_uc004czc.2_Missense_Mutation_p.L720I|GPR64_uc004czd.2_Missense_Mutation_p.L712I|GPR64_uc004cze.2_Missense_Mutation_p.L706I|GPR64_uc004czf.2_Missense_Mutation_p.L698I|GPR64_uc004cza.2_Missense_Mutation_p.L714I|GPR64_uc004cyw.2_Missense_Mutation_p.L720I|GPR64_uc010nfj.2_Missense_Mutation_p.L617I	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	736	Cytoplasmic (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					CAGAATTTAAGGATGTATTTT	0.408			NA											11	132					6.40141e-05	8.47718e-05	0.000978	1	0
MAGEB18	286514	broad.mit.edu	37	X	26157547	26157547	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:26157547C>A	uc004dbq.1	+	2	632	c.445C>A	c.(445-447)CTC>ATC	p.L149I		NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	149	MAGE.						protein binding			central_nervous_system(1)	1						CAATGAGATCCTCAAGAGAGC	0.418			NA											3	11					6.4e-05	8.47718e-05	0.004672	1	0
GK	2710	broad.mit.edu	37	X	30709248	30709248	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:30709248G>C	uc004dch.3	+	5	525	c.346G>C	c.(346-348)GAT>CAT	p.D116H	GK_uc010ngj.2_Missense_Mutation_p.D116H|GK_uc004dci.3_Missense_Mutation_p.D116H|GK_uc011mjz.1_5'UTR|GK_uc011mka.1_5'UTR|GK_uc010ngk.2_5'UTR	NM_203391	NP_976325	P32189	GLPK_HUMAN	glycerol kinase isoform a	116					glycerol-3-phosphate metabolic process|triglyceride biosynthetic process	cytosol|mitochondrial outer membrane	ATP binding|glycerol kinase activity			central_nervous_system(1)	1						AGTGTGGCTTGATCTAAGAAC	0.289			NA											5	147					0	0	0.000602	0	0
CXorf22	170063	broad.mit.edu	37	X	35969251	35969251	+	Silent	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:35969251G>T	uc004ddj.2	+	5	719	c.660G>T	c.(658-660)GTG>GTT	p.V220V	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	220										large_intestine(1)|lung(1)|ovary(1)	3						CCTGTAGAGTGATTTTGCAAG	0.333			NA											9	58					0.000442599	0.000568287	0.006214	1	0
BCOR	54880	broad.mit.edu	37	X	39923699	39923699	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:39923699C>A	uc004den.3	-	7	3684	c.3392G>T	c.(3391-3393)CGG>CTG	p.R1131L	BCOR_uc004dep.3_Missense_Mutation_p.R1131L|BCOR_uc004deo.3_Missense_Mutation_p.R1113L|BCOR_uc010nhb.2_5'Flank|BCOR_uc004dem.3_Missense_Mutation_p.R1131L	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1131					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						CCTGTCCACCCGGAGGGTGGG	0.607			NA											7	51					2.0095e-06	2.83299e-06	0.001984	1	0
DDX3X	1654	broad.mit.edu	37	X	41196688	41196688	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:41196688G>A	uc004dfe.2	+	2	928	c.73G>A	c.(73-75)GAT>AAT	p.D25N	DDX3X_uc004dfd.1_RNA|DDX3X_uc010nhf.1_Missense_Mutation_p.D25N|DDX3X_uc004dff.2_Missense_Mutation_p.D25N|DDX3X_uc011mkq.1_Missense_Mutation_p.D25N|DDX3X_uc011mkr.1_Missense_Mutation_p.D25N|DDX3X_uc011mks.1_Missense_Mutation_p.D25N|DDX3X_uc004dfg.2_RNA|DDX3X_uc011mkt.1_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	25					interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						GAACTCTTCAGATAATCAGAG	0.408			NA								HNSCC(61;0.18)			7	116					0	0	0.00308	0	0
RP2	6102	broad.mit.edu	37	X	46712938	46712938	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:46712938G>T	uc004dgw.3	+	2	319	c.130G>T	c.(130-132)GGA>TGA	p.G44*		NM_006915	NP_008846	O75695	XRP2_HUMAN	XRP2 protein	44	C-CAP/cofactor C-like.				cell morphogenesis|CTP biosynthetic process|GTP biosynthetic process|protein folding|UTP biosynthetic process|visual perception	cytoplasm|plasma membrane	ATP binding|GTP binding|GTPase activator activity|nucleoside diphosphate kinase activity|unfolded protein binding				0						CATGTTCAGTGGACTGAAGGA	0.333			NA											7	95					8.12818e-05	0.000106968	0.001984	1	0
WDR13	64743	broad.mit.edu	37	X	48458017	48458017	+	Missense_Mutation	SNP	T	T	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:48458017T>G	uc004dkh.1	+	5	582	c.435T>G	c.(433-435)AGT>AGG	p.S145R	WDR13_uc010nif.1_Missense_Mutation_p.S23R|WDR13_uc004dki.1_Missense_Mutation_p.S53R|WDR13_uc004dkj.1_Missense_Mutation_p.S145R|WDR13_uc004dkk.1_Missense_Mutation_p.S53R|WDR13_uc004dkl.3_Missense_Mutation_p.S53R|WDR13_uc011mme.1_Missense_Mutation_p.S23R	NM_017883	NP_060353	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13 protein	145						cytoplasm|nucleus				ovary(2)	2						CAGAGGCAAGTCGGGCCATGG	0.607			NA											7	99					0	0	0.001984	0	0
WNK3	65267	broad.mit.edu	37	X	54264888	54264888	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:54264888T>C	uc004dtd.1	-	19	4199	c.3760A>G	c.(3760-3762)AGA>GGA	p.R1254G	WNK3_uc004dtc.1_Missense_Mutation_p.R1301G	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1254					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						ATTGCTGATCTCATCTCTTCT	0.378			NA											10	36					0	0	0.006214	0	0
ALAS2	212	broad.mit.edu	37	X	55052311	55052311	+	Silent	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:55052311C>A	uc004dua.3	-	2	261	c.123G>T	c.(121-123)CTG>CTT	p.L41L	ALAS2_uc004dub.3_Silent_p.L65L|ALAS2_uc004dud.3_Silent_p.L41L	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	41					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	CTTGGGTAGCCAGGATGGGAC	0.542			NA											12	86					7.93312e-07	1.14129e-06	0.00245	1	0
MED12	9968	broad.mit.edu	37	X	70356805	70356805	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:70356805C>T	uc004dyy.2	+	38	5676	c.5477C>T	c.(5476-5478)CCT>CTT	p.P1826L	MED12_uc011mpq.1_Missense_Mutation_p.P1826L|MED12_uc004dyz.2_Missense_Mutation_p.P1826L|MED12_uc004dza.2_Missense_Mutation_p.P1673L|MED12_uc010nla.2_Missense_Mutation_p.P452L	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1826	Interaction with CTNNB1 and GLI3.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding	p.T1826I(1)		ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CACCCAAACCCTGGTTCTATA	0.582			NA											4	30					0	0	0.000248	0	0
KIAA2022	340533	broad.mit.edu	37	X	73960592	73960592	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:73960592G>T	uc004eby.2	-	3	4417	c.3800C>A	c.(3799-3801)CCT>CAT	p.P1267H		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1267					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						AGAGGCCATAGGGCCACCATG	0.527			NA											8	53					0.00307968	0.00382243	0.00308	1	0
KIAA2022	340533	broad.mit.edu	37	X	73961412	73961412	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:73961412C>T	uc004eby.2	-	3	3597	c.2980G>A	c.(2980-2982)GAT>AAT	p.D994N		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	994					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GCCATTGAATCAAAGCTAAAG	0.428			NA											14	49					0	0	0.001855	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83319979	83319979	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:83319979C>A	uc004eej.1	-	21	2189	c.2112G>T	c.(2110-2112)AAG>AAT	p.K704N	RPS6KA6_uc011mqt.1_Missense_Mutation_p.K704N|RPS6KA6_uc011mqu.1_Missense_Mutation_p.K601N	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	704					axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						TTTGTTTTACCTTAACAACAT	0.353			NA											11	147					0.00136819	0.00173213	0.001368	1	0
RPS6KA6	27330	broad.mit.edu	37	X	83362701	83362701	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:83362701G>C	uc004eej.1	-	13	1118	c.1041C>G	c.(1039-1041)TTC>TTG	p.F347L	RPS6KA6_uc011mqt.1_Missense_Mutation_p.F347L|RPS6KA6_uc011mqu.1_Missense_Mutation_p.F244L	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	347	AGC-kinase C-terminal.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						AAGCAGGTTTGAAAGGAGGTT	0.299			NA											3	46					0	0	0.000248	0	0
HDX	139324	broad.mit.edu	37	X	83599336	83599336	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:83599336C>T	uc004eek.1	-	6	1691	c.1582G>A	c.(1582-1584)GAA>AAA	p.E528K	HDX_uc011mqv.1_Missense_Mutation_p.E528K|HDX_uc004eel.1_Missense_Mutation_p.E470K	NM_144657	NP_653258	Q7Z353	HDX_HUMAN	highly divergent homeobox	528						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)	2						GGCCCAGCTTCCTCTCCTGGT	0.463	Pancreas(53;231 1169 36156 43751 51139)		NA											4	95					0	0	0.000248	0	0
HDX	139324	broad.mit.edu	37	X	83724224	83724224	+	Silent	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:83724224T>A	uc004eek.1	-	3	616	c.507A>T	c.(505-507)CTA>CTT	p.L169L	HDX_uc011mqv.1_Silent_p.L169L|HDX_uc004eel.1_Silent_p.L111L	NM_144657	NP_653258	Q7Z353	HDX_HUMAN	highly divergent homeobox	169						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TTTTTTCACCTAGGAGTAGGG	0.368	Pancreas(53;231 1169 36156 43751 51139)		NA											27	138					0	0	0.005443	0	0
POF1B	79983	broad.mit.edu	37	X	84559397	84559397	+	Silent	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:84559397C>A	uc004eer.2	-	14	1664	c.1518G>T	c.(1516-1518)CTG>CTT	p.L506L	POF1B_uc004ees.2_Silent_p.L506L	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	506							actin binding				0						GCAAGCTTGTCAGTTCATGAA	0.373			NA											16	47					0.00316338	0.00391863	0.003163	1	0
FAM133A	286499	broad.mit.edu	37	X	92965126	92965126	+	Silent	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:92965126G>A	uc004efr.1	+	4	1021	c.708G>A	c.(706-708)AAG>AAA	p.K236K		NM_173698	NP_775969	Q8N9E0	F133A_HUMAN	hypothetical protein LOC286499	236	Lys-rich.										0						atagtaagaagaagaaaaaga	0.279			NA											4	32					0	0	0.000248	0	0
SRPX2	27286	broad.mit.edu	37	X	99920554	99920554	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:99920554G>T	uc004egb.2	+	7	1161	c.681G>T	c.(679-681)GAG>GAT	p.E227D		NM_014467	NP_055282	O60687	SRPX2_HUMAN	sushi-repeat-containing protein, X-linked 2	227	HYR.				angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			ovary(2)	2						GGGGCCCTGAGCCTGGCTCTC	0.527			NA											9	122					1.12685e-05	1.54393e-05	0.004482	1	0
NOX1	27035	broad.mit.edu	37	X	100106267	100106267	+	Silent	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:100106267C>T	uc004egj.2	-	8	1058	c.852G>A	c.(850-852)AGG>AGA	p.R284R	NOX1_uc004egl.3_Silent_p.R284R|NOX1_uc010nne.2_Silent_p.R247R	NM_007052	NP_008983	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1 isoform long	284	FAD-binding FR-type.|Extracellular (Potential).				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			ovary(1)	1						ACCGGAGGATCCTTTCACAGA	0.423			NA											9	26					0	0	0.006214	0	0
GLA	2717	broad.mit.edu	37	X	100653523	100653523	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:100653523A>T	uc004ehl.1	-	6	944	c.834T>A	c.(832-834)AAT>AAA	p.N278K		NM_000169	NP_000160	P06280	AGAL_HUMAN	alpha-galactosidase A precursor	278					glycoside catabolic process|glycosphingolipid catabolic process|glycosylceramide catabolic process|negative regulation of nitric oxide biosynthetic process|negative regulation of nitric-oxide synthase activity|oligosaccharide metabolic process	extracellular region|Golgi apparatus|lysosome	cation binding|protein homodimerization activity|raffinose alpha-galactosidase activity|receptor binding				0					Agalsidase beta(DB00103)	TTACTTGCTGATTCCAGCTGA	0.443	Colon(193;776 2816 31189 44474)		NA											4	182					0	0	0.000248	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	105011541	105011541	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:105011541A>T	uc004elz.1	+	11	2704	c.1948A>T	c.(1948-1950)AAC>TAC	p.N650Y		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	650	Cytoplasmic (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						GACGCTACTCAACGGACAGCT	0.463			NA											32	128					0	0	0.001786	0	0
CHRDL1	91851	broad.mit.edu	37	X	109943926	109943926	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:109943926G>A	uc004eou.3	-	7	914	c.565C>T	c.(565-567)CAT>TAT	p.H189Y	CHRDL1_uc004eov.2_Missense_Mutation_p.H183Y|CHRDL1_uc004eow.2_Missense_Mutation_p.H188Y|CHRDL1_uc010nps.2_Missense_Mutation_p.H188Y|CHRDL1_uc004eot.2_Missense_Mutation_p.H109Y|CHRDL1_uc011mss.1_Missense_Mutation_p.H103Y	NM_001143981	NP_001137453	Q9BU40	CRDL1_HUMAN	chordin-like 1 isoform 1 precursor	182					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region					0						CCATCAGAATGTTCCCATGAC	0.408			NA											10	99					0	0	0.008291	0	0
PAK3	5063	broad.mit.edu	37	X	110459767	110459767	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:110459767C>A	uc004epa.2	+	14	1598	c.1571C>A	c.(1570-1572)TCT>TAT	p.S524Y	PAK3_uc010npt.1_Missense_Mutation_p.S509Y|PAK3_uc010npu.1_Missense_Mutation_p.S509Y|PAK3_uc004eoy.1_Missense_Mutation_p.S264Y|PAK3_uc004eoz.2_Missense_Mutation_p.S509Y|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_Missense_Mutation_p.S545Y|PAK3_uc010npw.1_Missense_Mutation_p.S530Y	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	524	Protein kinase.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						AGGCGAGGATCTGCCAAGGAG	0.433			NA								TSP Lung(19;0.15)			13	118					3.27435e-08	4.97042e-08	0.00245	1	0
CAPN6	827	broad.mit.edu	37	X	110494870	110494870	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:110494870C>A	uc004epc.1	-	6	968	c.800G>T	c.(799-801)AGA>ATA	p.R267I	CAPN6_uc011msu.1_Missense_Mutation_p.R12I	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	267	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						TTCCACAAGTCTCTCTCCAAG	0.483			NA											43	477					7.63091e-17	1.31977e-16	0.007835	1	0
KIAA1210	57481	broad.mit.edu	37	X	118221462	118221462	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:118221462C>A	uc004era.3	-	11	3731	c.3731G>T	c.(3730-3732)AGT>ATT	p.S1244I		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1244										ovary(4)|skin(1)	5						AGGATTAGCACTCCCTGAATC	0.463			NA											7	43					1.06961e-07	1.61206e-07	0.00308	1	0
ARHGAP36	158763	broad.mit.edu	37	X	130220361	130220361	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:130220361C>G	uc004evz.2	+	10	1685	c.1340C>G	c.(1339-1341)GCA>GGA	p.A447G	ARHGAP36_uc004ewa.2_Missense_Mutation_p.A435G|ARHGAP36_uc004ewb.2_Missense_Mutation_p.A416G|ARHGAP36_uc004ewc.2_Missense_Mutation_p.A311G	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	447					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						AGCCCGGAAGCACTTGATTTT	0.483			NA											34	91					0	0	0.003755	0	0
GPR112	139378	broad.mit.edu	37	X	135427235	135427235	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:135427235C>A	uc004ezu.1	+	6	1661	c.1370C>A	c.(1369-1371)GCA>GAA	p.A457E	GPR112_uc010nsb.1_Missense_Mutation_p.A252E|GPR112_uc010nsc.1_Missense_Mutation_p.A224E	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	457	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ACTTCACCTGCATCTACTCAT	0.493			NA											13	115					2.27111e-07	3.35891e-07	0.001368	1	0
GPR101	83550	broad.mit.edu	37	X	136113029	136113029	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:136113029C>T	uc011mwh.1	-	1	805	c.805G>A	c.(805-807)GAG>AAG	p.E269K		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	269	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					GCCTTGACCTCACCTTCATGC	0.572			NA											29	263					0	0	0.00632	0	0
F9	2158	broad.mit.edu	37	X	138644074	138644074	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:138644074T>A	uc004fas.1	+	8	1259	c.1230T>A	c.(1228-1230)GAT>GAA	p.D410E	F9_uc004fat.1_Missense_Mutation_p.D372E	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	410	Peptidase S1.		D -> H (in HEMB; Mechtal).		blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	GTCAAGGAGATAGTGGGGGAC	0.438			NA											34	153					0	0	0.004289	0	0
F9	2158	broad.mit.edu	37	X	138644077	138644077	+	Missense_Mutation	SNP	T	T	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:138644077T>G	uc004fas.1	+	8	1262	c.1233T>G	c.(1231-1233)AGT>AGG	p.S411R	F9_uc004fat.1_Missense_Mutation_p.S373R	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	411	Peptidase S1.	Charge relay system.	S -> I (in HEMB; Schmallenberg).|S -> G (in HEMB; Varel).		blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	AAGGAGATAGTGGGGGACCCC	0.433			NA											34	150					0	0	0.004289	0	0
SLITRK4	139065	broad.mit.edu	37	X	142716499	142716499	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:142716499C>G	uc004fbx.2	-	2	2802	c.2426G>C	c.(2425-2427)AGT>ACT	p.S809T	SLITRK4_uc004fby.2_Missense_Mutation_p.S809T	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	809	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					AAAATACTCACTCTTCCTTTG	0.423			NA											12	132					0	0	0.000978	0	0
GPR50	9248	broad.mit.edu	37	X	150345268	150345268	+	Silent	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:150345268G>T	uc010ntg.1	+	1	210	c.75G>T	c.(73-75)CCG>CCT	p.P25P	uc004fes.1_RNA|GPR50_uc011myc.1_Silent_p.P25P	NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	25	Extracellular (Potential).				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AATACCCACCGGCTCTAATCA	0.517			NA											19	151					5.03518e-11	8.1101e-11	0.007413	1	0
CNGA2	1260	broad.mit.edu	37	X	150911089	150911089	+	Silent	SNP	G	G	T	rs146197221	byFrequency	TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:150911089G>T	uc004fey.1	+	6	788	c.564G>T	c.(562-564)GCG>GCT	p.A188A		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	188	Helical; Name=H2; (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TCTACATTGCGGACCTCTTCA	0.532			NA											7	163					2.0095e-06	2.83299e-06	0.001984	1	0
PLXNB3	5365	broad.mit.edu	37	X	153039543	153039543	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:153039543T>A	uc004fii.2	+	20	3683	c.3509T>A	c.(3508-3510)CTG>CAG	p.L1170Q	PLXNB3_uc010nuk.2_Missense_Mutation_p.L1193Q|PLXNB3_uc011mzd.1_Missense_Mutation_p.L809Q|PLXNB3_uc004fij.1_5'Flank|SRPK3_uc004fik.2_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	1170	IPT/TIG 4.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GGCCATGTCCTGGATGTGGAG	0.711			NA											3	16					0	0	0.004672	0	0
IRAK1	3654	broad.mit.edu	37	X	153284753	153284753	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:153284753G>A	uc004fjs.1	-	3	410	c.331C>T	c.(331-333)CCA>TCA	p.P111S	IRAK1_uc004fjr.1_Missense_Mutation_p.P111S|IRAK1_uc004fjt.1_Missense_Mutation_p.P111S|IRAK1_uc010nur.2_Missense_Mutation_p.P111S|IRAK1_uc004fju.2_Missense_Mutation_p.P137S	NM_001569	NP_001560	P51617	IRAK1_HUMAN	interleukin-1 receptor-associated kinase 1	111	ProST region.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|lipopolysaccharide-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein autophosphorylation|protein oligomerization|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway	cytosol|endosome membrane|interleukin-1 receptor complex	ATP binding|NF-kappaB-inducing kinase activity|protein binding|protein heterodimerization activity|protein homodimerization activity|ubiquitin-protein ligase activity			lung(5)|ovary(2)|breast(1)|central_nervous_system(1)	9	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTGGTGCCTGGGGACGGAAGC	0.736			NA											3	36					0	0	0.004672	0	0
F8	2157	broad.mit.edu	37	X	154065930	154065930	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:154065930A>T	uc004fmt.2	-	26	7169	c.6998T>A	c.(6997-6999)GTG>GAG	p.V2333E	F8_uc004fms.2_Missense_Mutation_p.V198E	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	2333	F5/8 type C 2.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	AATCTGGTGCACCCAACTCTG	0.572			NA											4	25					0	0	0.000248	0	0
F8	2157	broad.mit.edu	37	X	154157435	154157435	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:154157435G>T	uc004fmt.2	-	14	4801	c.4630C>A	c.(4630-4632)CTT>ATT	p.L1544I		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	1544	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CCCTGAAGAAGGCTCCCTTCC	0.468			NA											18	221					5.35267e-07	7.84314e-07	0.007413	1	0
RAB39B	116442	broad.mit.edu	37	X	154490325	154490325	+	Silent	SNP	G	G	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:154490325G>A	uc004fne.2	-	2	684	c.405C>T	c.(403-405)CGC>CGT	p.R135R		NM_171998	NP_741995	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	135					protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CGGCCTCGTGGCGAGTCACTT	0.493			NA											20	183					0	0	0.008871	0	0
TMLHE	55217	broad.mit.edu	37	X	154736778	154736778	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:154736778C>A	uc004fnn.2	-	6	942	c.776G>T	c.(775-777)TGT>TTT	p.C259F	TMLHE_uc004fno.2_Missense_Mutation_p.C259F|TMLHE_uc004fnp.3_Missense_Mutation_p.C259F	NM_018196	NP_060666	Q9NVH6	TMLH_HUMAN	trimethyllysine hydroxylase, epsilon	259					carnitine biosynthetic process	mitochondrial matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|trimethyllysine dioxygenase activity			ovary(1)	1	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Succinic acid(DB00139)|Vitamin C(DB00126)	ATGTTTAAGACAATGAAACAC	0.358			NA											20	216					4.16121e-05	5.55706e-05	0.00278	1	0
CSMD2	114784	broad.mit.edu	37	1	34049270	34049270	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:34049270delC	uc001bxn.1	-	48	7247	c.7218delG	c.(7216-7218)AAGfs	p.K2406fs	CSMD2_uc001bxm.1_Frame_Shift_Del_p.K2404fs	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2406	CUB 14.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CATCATATTGCTTCTCGCTGA	0.398			NA											23	209	---	---	---	---	NA	NA	NA	NA	NA
LAMB3	3914	broad.mit.edu	37	1	209799153	209799153	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr1:209799153delT	uc001hhg.2	-	13	2206	c.1816delA	c.(1816-1818)ACCfs	p.T606fs	LAMB3_uc009xco.2_Frame_Shift_Del_p.T606fs|LAMB3_uc001hhh.2_Frame_Shift_Del_p.T606fs|LAMB3_uc010psl.1_Intron|hsa-mir-4260|MI0015859_5'Flank	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	606	Domain II.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		AGGCTGGCGGTGGCATTGCGG	0.622			NA											13	70	---	---	---	---	NA	NA	NA	NA	NA
OR52B4	143496	broad.mit.edu	37	11	4389086	4389087	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:4389086_4389087insA	uc010qye.1	-	1	439_440	c.439_440insT	c.(439-441)TGTfs	p.C147fs		NM_001005161	NP_001005161	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		GACAGTCACACAAATTTTCTTG	0.381			NA											14	85	---	---	---	---	NA	NA	NA	NA	NA
IFT46	56912	broad.mit.edu	37	11	118430510	118430512	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	TCC	TCC	-	-	TCC	TCC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr11:118430510_118430512delTCC	uc001ptp.1	-	3	411_413	c.33_35delGGA	c.(31-36)GAGGAA>GAA	p.11_12EE>E	IFT46_uc001pto.1_In_Frame_Del_p.11_12EE>E|IFT46_uc009zaf.1_In_Frame_Del_p.11_12EE>E	NM_020153	NP_064538	Q9NQC8	IFT46_HUMAN	IFT46	11_12					flagellum assembly|intraflagellar transport|protein stabilization	microtubule basal body|microtubule-based flagellum|nucleus	protein C-terminus binding				0						CTTGTTATTTTCCTCTTCACACT	0.374			NA											10	59	---	---	---	---	NA	NA	NA	NA	NA
DNAH10	196385	broad.mit.edu	37	12	124323158	124323158	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr12:124323158delC	uc001uft.3	+	28	4729	c.4704delC	c.(4702-4704)TTCfs	p.F1568fs		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1568	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TCCCAAGGTTCTTCTTCATTT	0.527			NA											17	107	---	---	---	---	NA	NA	NA	NA	NA
SLC6A11	6538	broad.mit.edu	37	3	10861452	10861466	+	In_Frame_Del	DEL	CATCCTGGCATGGGC	CATCCTGGCATGGGC	-			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	CATCCTGGCATGGGC	CATCCTGGCATGGGC	-	-	CATCCTGGCATGGGC	CATCCTGGCATGGGC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr3:10861452_10861466delCATCCTGGCATGGGC	uc003bvz.2	+	3	481_495	c.447_461delCATCCTGGCATGGGC	c.(445-462)ATCATCCTGGCATGGGCC>ATC	p.ILAWA150del	SLC6A11_uc003bvy.1_In_Frame_Del_p.ILAWA150del	NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	150_154	Extracellular (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		ACTACATCATCATCCTGGCATGGGCCATTTTTTAC	0.488			NA											12	153	---	---	---	---	NA	NA	NA	NA	NA
HADH	3033	broad.mit.edu	37	4	108948874	108948875	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr4:108948874_108948875insT	uc003hyq.2	+	6	816_817	c.667_668insT	c.(667-669)CTGfs	p.L223fs	HADH_uc010ilx.2_Frame_Shift_Ins_p.L223fs|HADH_uc010ily.2_Frame_Shift_Ins_p.L46fs|HADH_uc003hyr.2_Frame_Shift_Ins_p.L227fs	NM_005327	NP_005318	Q16836	HCDH_HUMAN	L-3-hydroxyacyl-Coenzyme A dehydrogenase	223					fatty acid beta-oxidation	mitochondrial matrix	3-hydroxyacyl-CoA dehydrogenase activity|NAD+ binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000168)	NADH(DB00157)	GAACCGCCTCCTGGTTCCATAC	0.47			NA											28	89	---	---	---	---	NA	NA	NA	NA	NA
TRIM15	89870	broad.mit.edu	37	6	30131581	30131582	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:30131581_30131582delCC	uc010jrx.2	+	1	599_600	c.120_121delCC	c.(118-123)CTCCCCfs	p.L40fs	TRIM10_uc003npn.2_5'Flank|TRIM10_uc003npo.3_5'Flank	NM_033229	NP_150232	Q9C019	TRI15_HUMAN	tripartite motif protein 15	40_41	RING-type.				mesodermal cell fate determination	intracellular	zinc ion binding				0						GGCTCTGCCTCCCCGCGCTCTC	0.663			NA											9	52	---	---	---	---	NA	NA	NA	NA	NA
FANCE	2178	broad.mit.edu	37	6	35424046	35424046	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:35424046delG	uc003oko.1	+	2	956	c.771delG	c.(769-771)ATGfs	p.M257fs	FANCE_uc010jvw.1_Frame_Shift_Del_p.M257fs	NM_021922	NP_068741	Q9HB96	FANCE_HUMAN	Fanconi anemia, complementation group E	257	Interaction with FANCC.				DNA repair	nucleoplasm	protein binding			ovary(1)|lung(1)|skin(1)	3						AGCCTGTCATGGCAGTTAAGA	0.498			NA	N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				48	180	---	---	---	---	NA	NA	NA	NA	NA
KIAA1009	22832	broad.mit.edu	37	6	84922740	84922740	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr6:84922740delT	uc010kbp.2	-	6	603	c.506delA	c.(505-507)AATfs	p.N169fs	KIAA1009_uc003pkj.3_Frame_Shift_Del_p.N93fs|KIAA1009_uc003pkk.2_Frame_Shift_Del_p.N169fs	NM_014895	NP_055710	Q5TB80	QN1_HUMAN	KIAA1009 protein	169					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			ovary(1)	1		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		GTTGGCTTGATTACTGGaaaa	0.284			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
STEAP1	26872	broad.mit.edu	37	7	89790346	89790352	+	Frame_Shift_Del	DEL	ATATTTT	ATATTTT	-			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	ATATTTT	ATATTTT	-	-	ATATTTT	ATATTTT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:89790346_89790352delATATTTT	uc003ujx.2	+	3	512_518	c.312_318delATATTTT	c.(310-318)CAATATTTTfs	p.Q104fs	STEAP1_uc010lem.2_Frame_Shift_Del_p.Q104fs	NM_012449	NP_036581	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the	104_106					electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	all_hematologic(106;0.112)					CCCATCAACAATATTTTTATAAAATTC	0.396			NA											26	95	---	---	---	---	NA	NA	NA	NA	NA
LAMB1	3912	broad.mit.edu	37	7	107569639	107569640	+	Frame_Shift_Ins	INS	-	-	TT			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr7:107569639_107569640insTT	uc003vew.2	-	31	5091_5092	c.4756_4757insAA	c.(4756-4758)ACAfs	p.T1586fs	LAMB1_uc003vev.2_Frame_Shift_Ins_p.T1610fs|LAMB1_uc003veu.2_Frame_Shift_Ins_p.T69fs	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1586	Potential.|Domain I.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTTAACATCTGTTGCACTTTTG	0.386			NA											20	139	---	---	---	---	NA	NA	NA	NA	NA
LPAR1	1902	broad.mit.edu	37	9	113704241	113704241	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chr9:113704241delA	uc004bfa.2	-	4	508	c.253delT	c.(253-255)TATfs	p.Y85fs	LPAR1_uc011lwm.1_Frame_Shift_Del_p.Y86fs|LPAR1_uc004bfb.2_Frame_Shift_Del_p.Y85fs|LPAR1_uc004bfc.2_Frame_Shift_Del_p.Y85fs|LPAR1_uc011lwn.1_Frame_Shift_Del_p.Y67fs|LPAR1_uc011lwo.1_Frame_Shift_Del_p.Y86fs|LPAR1_uc010mub.2_Frame_Shift_Del_p.Y85fs	NM_057159	NP_476500	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	85	Helical; Name=2; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				ovary(2)	2						ATTAGGTAATAAATAGGAAAA	0.458	NSCLC(115;661 2323 9836 34256)		NA											21	109	---	---	---	---	NA	NA	NA	NA	NA
NLGN4X	57502	broad.mit.edu	37	X	5821268	5821269	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:5821268_5821269insA	uc010ndh.2	-	5	1951_1952	c.1450_1451insT	c.(1450-1452)TGGfs	p.W484fs	NLGN4X_uc004crp.2_Frame_Shift_Ins_p.W504fs|NLGN4X_uc004crq.2_Frame_Shift_Ins_p.W484fs|NLGN4X_uc010ndi.2_Frame_Shift_Ins_p.W521fs|NLGN4X_uc004crr.2_Frame_Shift_Ins_p.W484fs|NLGN4X_uc010ndj.2_Frame_Shift_Ins_p.W484fs	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	484	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						CGAATCTGCCCAGCTGGGCTTC	0.594			NA											12	118	---	---	---	---	NA	NA	NA	NA	NA
ERCC6L	54821	broad.mit.edu	37	X	71426054	71426055	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-6777-01A-11D-1855-08	TCGA-44-6777-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	32a0f0f3-3879-4b96-b9bb-eeab87827f6e	2caae538-5cfd-474a-8619-f44f80e1ac9f	g.chrX:71426054_71426055insT	uc004eaq.1	-	2	2659_2660	c.2562_2563insA	c.(2560-2565)CAAGAGfs	p.Q854fs	PIN4_uc004eao.1_Intron|ERCC6L_uc004eap.1_Frame_Shift_Ins_p.Q731fs	NM_017669	NP_060139	Q2NKX8	ERC6L_HUMAN	excision repair protein ERCC6-like	854_855					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			ovary(3)	3	Renal(35;0.156)					TGCAGTGCCTCTTGCTTAGGCC	0.366			NA											10	70	---	---	---	---	NA	NA	NA	NA	NA
