Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SKI	6497	broad.mit.edu	37	1	2160515	2160515	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:2160515G>C	uc001aja.3	+	1	382	c.310G>C	c.(310-312)GTA>CTA	p.V104L		NM_003036	NP_003027	P12755	SKI_HUMAN	v-ski sarcoma viral oncogene homolog	104					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)		CTGCGAGACCGTACTGGAAGG	0.692	Ovarian(177;144 1678 13697 20086 27838 40755)		NA											5	10					0	0	0.000602	0	0
ARHGEF16	27237	broad.mit.edu	37	1	3390072	3390072	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:3390072C>G	uc001akg.3	+	8	1539	c.1291C>G	c.(1291-1293)CCC>GCC	p.P431A	ARHGEF16_uc001aki.2_Missense_Mutation_p.P143A|ARHGEF16_uc001akj.2_Missense_Mutation_p.P143A|ARHGEF16_uc009vli.1_Missense_Mutation_p.P135A|ARHGEF16_uc010nzh.1_Missense_Mutation_p.P135A	NM_014448	NP_055263	Q5VV41	ARHGG_HUMAN	Rho guanine exchange factor 16	431	DH.|Required for RHOG activation and mediates interaction with EPHA2.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		GACCCGGCTGCCCCTCCTGAT	0.682			NA											23	49					0	0	0.00632	0	0
GMEB1	10691	broad.mit.edu	37	1	29030804	29030804	+	Silent	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:29030804T>C	uc001bra.2	+	8	999	c.861T>C	c.(859-861)GTT>GTC	p.V287V	GMEB1_uc001bqz.2_Silent_p.V277V|GMEB1_uc001brb.2_Silent_p.V277V	NM_006582	NP_006573	Q9Y692	GMEB1_HUMAN	glucocorticoid modulatory element binding	287					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|metal ion binding|transcription coactivator activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Breast(348;0.00502)|Renal(390;0.00555)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		TCAGGGGAGTTCAGCAGCGGC	0.468			NA											10	62					0	0	0.001368	0	0
CSMD2	114784	broad.mit.edu	37	1	34276467	34276467	+	Splice_Site	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:34276467T>A	uc001bxn.1	-	10	1234	c.1205_splice	c.e10-1	p.A402_splice	CSMD2_uc001bxm.1_Splice_Site_p.A442_splice	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2							integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ACATGCGGGCTGCAGAGGAGA	0.532			NA											11	85					0	0	0.008291	0	0
ZMYM4	9202	broad.mit.edu	37	1	35881308	35881308	+	Silent	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:35881308A>T	uc001byt.2	+	28	4382	c.4302A>T	c.(4300-4302)TCA>TCT	p.S1434S	ZMYM4_uc009vuu.2_Silent_p.S1402S|ZMYM4_uc001byu.2_Silent_p.S1110S|ZMYM4_uc009vuv.2_Silent_p.S1173S	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	1434					multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AGCAGGAGTCAGAACCAGGTA	0.413			NA											19	40					0	0	0.007413	0	0
RHBDL2	54933	broad.mit.edu	37	1	39352280	39352280	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:39352280T>C	uc001ccu.1	-	8	1036	c.808A>G	c.(808-810)AAA>GAA	p.K270E	RHBDL2_uc010oin.1_3'UTR|RHBDL2_uc010oio.1_Missense_Mutation_p.K350E	NM_017821	NP_060291	Q9NX52	RHBL2_HUMAN	rhomboid protease 2	270					proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity				0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			AGCAGTGCTTTATCAAAGCAG	0.418			NA											10	94					0	0	0.000978	0	0
HIVEP3	59269	broad.mit.edu	37	1	42050182	42050182	+	Missense_Mutation	SNP	G	G	T	rs142189176		TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:42050182G>T	uc001cgz.3	-	4	1500	c.287C>A	c.(286-288)CCG>CAG	p.P96Q	HIVEP3_uc001cha.3_Missense_Mutation_p.P96Q|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	96					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AGGGTGCTGCGGAAGCTGTGA	0.587			NA											63	183					1.35869e-18	2.15825e-18	0.00361	1	0
CCDC30	728621	broad.mit.edu	37	1	43002166	43002166	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:43002166A>G	uc009vwk.1	+	2	121	c.11A>G	c.(10-12)GAA>GGA	p.E4G	CCDC30_uc001chm.2_5'UTR|CCDC30_uc001chn.2_Intron|CCDC30_uc010oju.1_RNA|CCDC30_uc001chp.2_Missense_Mutation_p.E4G	NM_001080850	NP_001074319	Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	4											0						ATGAGCCAAGAAAAAAATGAA	0.333			NA											10	62					0	0	0.008291	0	0
FAF1	11124	broad.mit.edu	37	1	51001120	51001120	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:51001120G>A	uc009vyx.1	-	16	1478	c.1415C>T	c.(1414-1416)ACA>ATA	p.T472I	FAF1_uc009vyw.1_RNA|FAF1_uc001cse.1_Missense_Mutation_p.T472I|FAF1_uc010onc.1_Missense_Mutation_p.T230I	NM_007051	NP_008982	Q9UNN5	FAF1_HUMAN	FAS-associated factor 1	472					apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		CTCATCTACTGTTGTGTTCCC	0.328			NA											13	67					0	0	0.001368	0	0
DMRTB1	63948	broad.mit.edu	37	1	53927203	53927203	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:53927203C>A	uc001cvq.1	+	2	690	c.635C>A	c.(634-636)TCC>TAC	p.S212Y		NM_033067	NP_149056	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal,	212	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						CCTGGTGGCTCCAGCATGCAC	0.652			NA											16	120					1.15088e-07	1.47328e-07	0.004007	1	0
CACHD1	57685	broad.mit.edu	37	1	65119459	65119459	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:65119459C>T	uc001dbo.1	+	11	1511	c.1406C>T	c.(1405-1407)CCA>CTA	p.P469L	CACHD1_uc001dbp.1_Missense_Mutation_p.P224L|CACHD1_uc001dbq.1_Missense_Mutation_p.P224L	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	520	Extracellular (Potential).|Cache 1.				calcium ion transport	integral to membrane				ovary(2)	2						CTTATGCACCCATCTCTTACC	0.338			NA											13	212					0	0	0.001855	0	0
CTH	1491	broad.mit.edu	37	1	70904452	70904452	+	Silent	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:70904452G>T	uc001dfd.2	+	11	1278	c.1134G>T	c.(1132-1134)GTG>GTT	p.V378V	CTH_uc001dfe.2_Silent_p.V334V|CTH_uc010oqq.1_Silent_p.V346V	NM_001902	NP_001893	P32929	CGL_HUMAN	cystathionase isoform 1	378					cysteine biosynthetic process|hydrogen sulfide biosynthetic process|protein homotetramerization|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	cytoplasm|nucleus	cystathionine gamma-lyase activity|L-cysteine desulfhydrase activity|pyridoxal phosphate binding			lung(1)	1					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	GACTTTCTGTGGGCTTAGAGG	0.358			NA											30	89					1.62565e-12	2.35719e-12	0.002445	1	0
C1orf173	127254	broad.mit.edu	37	1	75037302	75037302	+	Silent	SNP	C	C	T	rs4366277		TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:75037302C>T	uc001dgg.2	-	14	4311	c.4092G>A	c.(4090-4092)GAG>GAA	p.E1364E		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1364	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCTCGGCTGTCTCCGAACCTG	0.517			NA											46	120					0	0	0.00361	0	0
LPHN2	23266	broad.mit.edu	37	1	82417712	82417712	+	Silent	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:82417712T>C	uc001dit.3	+	9	1849	c.1668T>C	c.(1666-1668)GCT>GCC	p.A556A	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Silent_p.A556A|LPHN2_uc001div.2_Silent_p.A556A|LPHN2_uc009wcd.2_Silent_p.A556A|LPHN2_uc001diw.2_Silent_p.A127A	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	556	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CAGTGTTTGCTGGGGATGTAA	0.428			NA											12	74					0	0	0.001368	0	0
LPHN2	23266	broad.mit.edu	37	1	82421638	82421638	+	Silent	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:82421638A>G	uc001dit.3	+	10	2041	c.1860A>G	c.(1858-1860)CAA>CAG	p.Q620Q	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Silent_p.Q620Q|LPHN2_uc001div.2_Silent_p.Q620Q|LPHN2_uc009wcd.2_Silent_p.Q620Q|LPHN2_uc001diw.2_Silent_p.Q204Q	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	633	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CTTCTGAACAAGCACATACTG	0.403			NA											17	99					0	0	0.006122	0	0
WDR63	126820	broad.mit.edu	37	1	85592345	85592345	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:85592345C>A	uc001dkt.2	+	20	2455	c.2264C>A	c.(2263-2265)TCT>TAT	p.S755Y	WDR63_uc009wcl.2_Missense_Mutation_p.S716Y	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	755										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		CCAGCCCAGTCTCAAAACATT	0.433			NA											17	91					3.32936e-07	4.19088e-07	0.006122	1	0
TGFBR3	7049	broad.mit.edu	37	1	92200438	92200438	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:92200438G>T	uc001doh.2	-	5	929	c.463C>A	c.(463-465)CAT>AAT	p.H155N	TGFBR3_uc009wde.2_5'UTR|TGFBR3_uc010osy.1_Missense_Mutation_p.H113N|TGFBR3_uc001doi.2_Missense_Mutation_p.H155N|TGFBR3_uc001doj.2_Missense_Mutation_p.H155N	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	155	Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		TCATTTCCATGGGGGAAGTTC	0.418			NA											52	202					9.22156e-22	1.52814e-21	0.00361	1	0
TGFBR3	7049	broad.mit.edu	37	1	92224265	92224265	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:92224265G>T	uc001doh.2	-	4	755	c.289C>A	c.(289-291)CAC>AAC	p.H97N	TGFBR3_uc009wde.2_5'UTR|TGFBR3_uc010osy.1_Missense_Mutation_p.H55N|TGFBR3_uc001doi.2_Missense_Mutation_p.H97N|TGFBR3_uc001doj.2_Missense_Mutation_p.H97N	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	97	Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		ACAGACTTGTGGTGGATGTGG	0.507			NA											13	128					7.03913e-09	9.36067e-09	0.001368	1	0
GLMN	11146	broad.mit.edu	37	1	92712203	92712203	+	Missense_Mutation	SNP	C	C	A	rs112947595		TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:92712203C>A	uc001dor.2	-	19	1784	c.1669G>T	c.(1669-1671)GTC>TTC	p.V557F	GLMN_uc009wdg.2_RNA|GLMN_uc001dos.2_Missense_Mutation_p.V543F	NM_053274	NP_444504	Q92990	GLMN_HUMAN	glomulin	557					muscle cell differentiation|negative regulation of T cell proliferation|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of phosphorylation|regulation of gene expression, epigenetic|vasculogenesis	intracellular	hepatocyte growth factor receptor binding			skin(1)	1		all_lung(203;0.00827)|Lung NSC(277;0.0295)		all cancers(265;0.00702)|GBM - Glioblastoma multiforme(16;0.0381)|Epithelial(280;0.0989)		GAATGCAGGACCTGCAATGCC	0.348			NA							Multiple_Glomus_Tumors_(of_the_Skin)_Familial				3	40					0.004672	0.00490625	0.004672	1	0
GFI1	2672	broad.mit.edu	37	1	92948935	92948935	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:92948935C>G	uc001dou.3	-	2	274	c.110G>C	c.(109-111)CGA>CCA	p.R37P	GFI1_uc001dov.3_Missense_Mutation_p.R37P|GFI1_uc001dow.3_Missense_Mutation_p.R37P	NM_001127215	NP_001120687	Q99684	GFI1_HUMAN	growth factor independent 1	37					negative regulation of calcidiol 1-monooxygenase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription, DNA-dependent|viral reproduction	nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)	1		all_lung(203;0.00292)|Lung NSC(277;0.0115)|all_neural(321;0.185)|Glioma(108;0.203)		OV - Ovarian serous cystadenocarcinoma(397;9.04e-07)|Epithelial(280;1.17e-05)|all cancers(265;5.61e-05)|GBM - Glioblastoma multiforme(16;0.0191)		CGCACCTGCTCGGCTAGGCGC	0.647			NA											7	21					0	0	0.004482	0	0
ABCA4	24	broad.mit.edu	37	1	94502755	94502755	+	Silent	SNP	C	C	A	rs147884766	byFrequency	TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:94502755C>A	uc001dqh.2	-	25	3863	c.3759G>T	c.(3757-3759)ACG>ACT	p.T1253T		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1253	Cytoplasmic.		T -> M (in FFM; could be a rare polymorphism).		phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GGTCAGCCAGCGTCTCCTCCA	0.483			NA											21	105					3.62473e-10	4.96016e-10	0.001882	1	0
SNX7	51375	broad.mit.edu	37	1	99161072	99161072	+	Splice_Site	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:99161072A>T	uc010ouc.1	+	5	692	c.640_splice	c.e5-2	p.E214_splice	SNX7_uc001dsa.2_Splice_Site_p.E150_splice|SNX7_uc010oud.1_Splice_Site_p.E159_splice	NM_015976	NP_057060	Q9UNH6	SNX7_HUMAN	sorting nexin 7 isoform a						cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		TTTTGTTTCTAGGAACTCTCT	0.393			NA											18	45					0	0	0.007413	0	0
LPPR4	9890	broad.mit.edu	37	1	99753654	99753654	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:99753654C>A	uc001dse.2	+	2	462	c.356C>A	c.(355-357)GCA>GAA	p.A119E	LPPR4_uc010oue.1_Missense_Mutation_p.A119E	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	119	Helical; (Potential).						phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		ACCCAGGAGGCAATTCCATTC	0.438			NA											32	97					8.16721e-17	1.26971e-16	0.002096	1	0
SLC25A24	29957	broad.mit.edu	37	1	108728465	108728465	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:108728465C>A	uc001dvn.3	-	2	509	c.295G>T	c.(295-297)GAC>TAC	p.D99Y	SLC25A24_uc001dvm.2_Missense_Mutation_p.D80Y	NM_013386	NP_037518	Q6NUK1	SCMC1_HUMAN	solute carrier family 25 member 24 isoform 1	99	EF-hand 3.|3 (Potential).|Mitochondrial intermembrane (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			ovary(1)	1		all_epithelial(167;3.72e-05)|all_lung(203;0.000567)|Lung NSC(277;0.0011)|Melanoma(281;0.211)		Colorectal(144;0.0345)|Lung(183;0.0971)|COAD - Colon adenocarcinoma(174;0.127)|Epithelial(280;0.134)		TTATTTTTGTCTAAACTCTTA	0.318			NA											4	24					0.00909568	0.00944648	0.009096	1	0
GSTM3	2947	broad.mit.edu	37	1	110280799	110280799	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:110280799C>T	uc001dyo.2	-	6	596	c.286G>A	c.(286-288)GAA>AAA	p.E96K	GSTM3_uc001dyp.2_Missense_Mutation_p.E93K|GSTM3_uc010ovv.1_Missense_Mutation_p.E96K	NM_000849	NP_000840	P21266	GSTM3_HUMAN	glutathione S-transferase mu 3	96	GST C-terminal.				establishment of blood-nerve barrier|glutathione metabolic process|response to estrogen stimulus	cytoplasm	glutathione transferase activity|identical protein binding				0		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Colorectal(144;0.0339)|Lung(183;0.0426)|all cancers(265;0.113)|Epithelial(280;0.125)|COAD - Colon adenocarcinoma(174;0.134)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	ATCTTTTCTTCTTCAGTCTCA	0.488			NA											7	50					0	0	0.001984	0	0
UBL4B	164153	broad.mit.edu	37	1	110655635	110655635	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:110655635G>T	uc001dzc.2	+	1	574	c.479G>T	c.(478-480)AGC>ATC	p.S160I		NM_203412	NP_981957	Q8N7F7	UBL4B_HUMAN	ubiquitin-like 4B	160						cytoplasm				ovary(1)	1		all_cancers(81;1.14e-05)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0236)|all cancers(265;0.0823)|Epithelial(280;0.0917)|Colorectal(144;0.109)|LUSC - Lung squamous cell carcinoma(189;0.134)		CGGCCTCAGAGCTCCTGTGAC	0.597			NA											5	24					5.9392e-07	7.40191e-07	0.001168	1	0
SLC6A17	388662	broad.mit.edu	37	1	110737302	110737302	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:110737302C>T	uc009wfq.2	+	9	1862	c.1401C>T	c.(1399-1401)ATC>ATT	p.I467I	SLC6A17_uc001dze.1_Silent_p.I65I	NM_001010898	NP_001010898	Q9H1V8	S6A17_HUMAN	solute carrier family 6, member 17	467	Helical; Name=8; (Potential).				alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			ovary(1)|pancreas(1)	2		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		TGATGCTTATCAACCTGGGCC	0.592			NA											10	50					0	0	0.000978	0	0
RBM15	64783	broad.mit.edu	37	1	110883936	110883936	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:110883936G>T	uc001dzl.1	+	1	1992	c.1909G>T	c.(1909-1911)GAC>TAC	p.D637Y	RBM15_uc001dzm.1_Missense_Mutation_p.D637Y|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	637	Arg-rich.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		CAGCAGCAGAGACCAGCCTAG	0.592			NA	T	MKL1	acute megakaryocytic leukemia								11	32					1.58986e-06	1.92726e-06	0.008291	1	0
PTGFRN	5738	broad.mit.edu	37	1	117492063	117492063	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:117492063G>T	uc001egv.1	+	4	1219	c.1082G>T	c.(1081-1083)CGG>CTG	p.R361L		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	361	Ig-like C2-type 3.|Extracellular (Potential).					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		TTACTGGTTCGGGATGTTAGC	0.562			NA											29	91					1.39806e-14	2.11249e-14	0.008361	1	0
CD101	9398	broad.mit.edu	37	1	117568211	117568211	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:117568211G>A	uc010oxb.1	+	8	2567	c.2509G>A	c.(2509-2511)GAG>AAG	p.E837K	CD101_uc009whd.2_Missense_Mutation_p.E837K|CD101_uc010oxc.1_Missense_Mutation_p.E837K|CD101_uc010oxd.1_Missense_Mutation_p.E775K	NM_004258	NP_004249	Q93033	IGSF2_HUMAN	immunoglobulin superfamily, member 2 precursor	837	Ig-like C2-type 7.|Extracellular (Potential).				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4						CTGCAGCCTGGAGAGTGTAGG	0.478			NA											9	80					0	0	0.006214	0	0
ADAM30	11085	broad.mit.edu	37	1	120437773	120437773	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:120437773C>T	uc001eij.2	-	1	1341	c.1187G>A	c.(1186-1188)GGT>GAT	p.G396D		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	396	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		AAGCACATAACCTAGTCCTGG	0.418			NA											19	213					0	0	0.007413	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144859821	144859821	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:144859821G>A	uc001elw.3	-	38	6554	c.6263C>T	c.(6262-6264)TCC>TTC	p.S2088F	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.S1982F|PDE4DIP_uc001elv.3_Missense_Mutation_p.S1095F	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	2088				Missing (in Ref. 4; CAH18128).	cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GTTAATGGAGGAGGGGCTGAG	0.572			NA	T	PDGFRB	MPD								12	92					0	0	0.001855	0	0
RPRD2	23248	broad.mit.edu	37	1	150432716	150432716	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:150432716T>G	uc009wlr.2	+	9	1535	c.1334T>G	c.(1333-1335)TTG>TGG	p.L445W	RPRD2_uc010pcc.1_Missense_Mutation_p.L419W|RPRD2_uc001eup.3_Missense_Mutation_p.L419W	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	445							protein binding			ovary(1)	1						GCATTGGCTTTGCCAAACCTG	0.473			NA											9	26					0	0	0.004482	0	0
TCHH	7062	broad.mit.edu	37	1	152082377	152082377	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:152082377G>C	uc001ezp.2	-	2	3316	c.3316C>G	c.(3316-3318)CGG>GGG	p.R1106G	TCHH_uc009wne.1_Missense_Mutation_p.R1106G	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1106	10 X 30 AA tandem repeats.|4-7.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCCTCTCCCGCTCCTGGCGC	0.174			NA											42	193					0	0	0.002522	0	0
FLG	2312	broad.mit.edu	37	1	152281931	152281931	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:152281931C>G	uc001ezu.1	-	3	5467	c.5431G>C	c.(5431-5433)GAC>CAC	p.D1811H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1811	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGAATGGTGTCCTGACCCTCT	0.597			NA							Ichthyosis				38	709					0	0	0.007835	0	0
FLG2	388698	broad.mit.edu	37	1	152325946	152325946	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:152325946C>A	uc001ezw.3	-	3	4389	c.4316G>T	c.(4315-4317)AGA>ATA	p.R1439I	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1439							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGATTGTGGTCTGTGTGAGCC	0.527			NA											159	396					6.28038e-61	1.10899e-60	0.00361	1	0
FLG2	388698	broad.mit.edu	37	1	152327665	152327665	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:152327665C>T	uc001ezw.3	-	3	2670	c.2597G>A	c.(2596-2598)GGA>GAA	p.G866E	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	866	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGATGTCTGTCCCGAACTTGA	0.493			NA											176	544					0	0	0.00361	0	0
LCE2D	353141	broad.mit.edu	37	1	152636817	152636817	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:152636817G>T	uc001fag.2	+	2	291	c.236G>T	c.(235-237)CGT>CTT	p.R79L		NM_178430	NP_848517	Q5TA82	LCE2D_HUMAN	late cornified envelope 2D	79	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACAGGCCCCGTCTCTTCCAC	0.682			NA											55	143					4.09106e-26	6.93183e-26	0.00361	1	0
KPRP	448834	broad.mit.edu	37	1	152732605	152732605	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:152732605C>A	uc001fal.1	+	2	599	c.541C>A	c.(541-543)CAG>AAG	p.Q181K		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	181	Gln-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATTCTCCACCCAGTGCCAGTA	0.557			NA											46	139					3.05275e-18	4.83565e-18	0.003214	1	0
UBAP2L	9898	broad.mit.edu	37	1	154201188	154201188	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:154201188G>T	uc001fep.3	+	4	433	c.266G>T	c.(265-267)GGA>GTA	p.G89V	UBAP2L_uc009wot.2_Missense_Mutation_p.G89V|UBAP2L_uc010pek.1_Missense_Mutation_p.G88V|UBAP2L_uc010pel.1_Missense_Mutation_p.G88V|UBAP2L_uc001fen.1_Missense_Mutation_p.G88V|UBAP2L_uc010pem.1_Missense_Mutation_p.G88V|UBAP2L_uc010pen.1_5'UTR	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	89	UBA.				binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTTCTGGAAGGAAACCCAGAC	0.423			NA											12	104					4.3838e-07	5.49981e-07	0.001855	1	0
ATP8B2	57198	broad.mit.edu	37	1	154313336	154313336	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:154313336G>T	uc001fex.2	+	13	1140	c.1140G>T	c.(1138-1140)GAG>GAT	p.E380D		NM_020452	NP_065185	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform a	366	Helical; (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GCAGTGTGGAGGTCATCCGTC	0.607			NA											39	91					9.14704e-12	1.3087e-11	0.00874	1	0
PBXIP1	57326	broad.mit.edu	37	1	154920756	154920756	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:154920756C>T	uc001ffr.2	-	6	555	c.496G>A	c.(496-498)GAG>AAG	p.E166K	PBXIP1_uc001ffs.2_Missense_Mutation_p.E137K|PBXIP1_uc010pep.1_Missense_Mutation_p.E11K	NM_020524	NP_065385	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein	166					cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			large_intestine(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GGGCCGGCCTCCCGGCCCCGC	0.682			NA											6	11					0	0	0.00308	0	0
SYT11	23208	broad.mit.edu	37	1	155851068	155851068	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:155851068G>C	uc001fmg.2	+	4	1328	c.1065G>C	c.(1063-1065)TTG>TTC	p.L355F	SYT11_uc010pgq.1_Missense_Mutation_p.L48F	NM_152280	NP_689493	Q9BT88	SYT11_HUMAN	synaptotagmin XI	355	C2 2.|Cytoplasmic (Potential).					cell junction|synaptic vesicle membrane	protein binding|transporter activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			AGTGCACTTTGAACCCCATCT	0.483			NA											138	421					0	0	0.00361	0	0
FCRL1	115350	broad.mit.edu	37	1	157765932	157765932	+	Missense_Mutation	SNP	C	C	A	rs147036979	byFrequency	TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:157765932C>A	uc001frg.2	-	11	1360	c.1247G>T	c.(1246-1248)AGG>ATG	p.R416M	FCRL1_uc001frf.2_RNA|FCRL1_uc001frh.2_Missense_Mutation_p.R415M|FCRL1_uc001fri.2_3'UTR|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	416	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GTTTGCTTTCCTCAGCCTGGA	0.468	GBM(54;482 1003 11223 30131 35730)		NA											14	82					9.31168e-06	1.11092e-05	0.001855	1	0
CD1D	912	broad.mit.edu	37	1	158151905	158151905	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:158151905G>T	uc001frr.2	+	4	911	c.412G>T	c.(412-414)GGA>TGA	p.G138*	CD1D_uc009wsr.1_Nonsense_Mutation_p.G138*|CD1D_uc009wss.2_Nonsense_Mutation_p.G138*|CD1D_uc009wst.1_Nonsense_Mutation_p.G34*	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	138	Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					AGCATTTCAAGGAAAAGATAT	0.512			NA											66	248					3.57465e-26	6.07046e-26	0.00361	1	0
SPTA1	6708	broad.mit.edu	37	1	158606521	158606521	+	Silent	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:158606521G>A	uc001fst.1	-	37	5419	c.5220C>T	c.(5218-5220)GAC>GAT	p.D1740D		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1740	Spectrin 17.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CTCTCCCATAGTCCTGGGAGC	0.478			NA											56	145					0	0	0.00361	0	0
CADM3	57863	broad.mit.edu	37	1	159163811	159163811	+	Silent	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:159163811T>A	uc001ftl.2	+	5	814	c.672T>A	c.(670-672)TCT>TCA	p.S224S	CADM3_uc009wsy.1_Intron|CADM3_uc001ftk.2_Silent_p.S258S	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	224	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					GATCCACCTCTCAACGCATTG	0.507			NA											6	81					0	0	0.00308	0	0
OR10J1	26476	broad.mit.edu	37	1	159409749	159409749	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:159409749C>A	uc010piv.1	+	1	201	c.201C>A	c.(199-201)CAC>CAA	p.H67Q	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	67	Helical; Name=2; (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					TTCATCTTCACACACCCATGT	0.453			NA											44	121					7.53189e-24	1.25643e-23	0.007835	1	0
DCAF8	50717	broad.mit.edu	37	1	160249886	160249886	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:160249886C>A	uc010pjc.1	-	4	576	c.304G>T	c.(304-306)GAG>TAG	p.E102*	PEX19_uc010pje.1_RNA|PEX19_uc001fvs.2_Nonsense_Mutation_p.E249*|PEX19_uc001fvt.2_Nonsense_Mutation_p.E159*	NM_015726	NP_056541	Q5TAQ9	DCAF8_HUMAN	DDB1 and CUL4 associated factor 8	Error:Variant_position_missing_in_Q5TAQ9_after_alignment						CUL4 RING ubiquitin ligase complex	protein binding			skin(2)	2						AGCACCATCTCAAAACGAGCC	0.493			NA											105	227					7.73176e-47	1.36209e-46	0.00361	1	0
NCSTN	23385	broad.mit.edu	37	1	160314522	160314522	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:160314522G>T	uc001fvx.2	+	2	220	c.96G>T	c.(94-96)AGG>AGT	p.R32S	COPA_uc009wti.2_5'Flank|COPA_uc001fvv.3_5'Flank|COPA_uc009wtj.1_5'Flank|NCSTN_uc009wtk.1_RNA|NCSTN_uc001fvy.2_Missense_Mutation_p.R12S|NCSTN_uc010pjf.1_Missense_Mutation_p.R32S	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	32					amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GTTTGTGCAGGGGAAACTCAG	0.438			NA											14	57					2.31682e-05	2.71255e-05	0.003163	1	0
LRRC52	440699	broad.mit.edu	37	1	165514132	165514132	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:165514132T>A	uc001gde.2	+	1	655	c.599T>A	c.(598-600)ATA>AAA	p.I200K	LOC400794_uc001gdc.2_Intron|LOC400794_uc001gdd.2_Intron|LOC400794_uc009wvd.2_Intron	NM_001005214	NP_001005214	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52 precursor	200	Extracellular (Potential).|LRRCT.					integral to membrane				ovary(1)	1	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					ATCTTCTTAATAGTGTTCCAT	0.498			NA											37	157					0	0	0.007835	0	0
FMO1	2326	broad.mit.edu	37	1	171252285	171252285	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:171252285G>T	uc009wvz.2	+	8	1322	c.1186G>T	c.(1186-1188)GTA>TTA	p.V396L	FMO1_uc010pme.1_Missense_Mutation_p.V333L|FMO1_uc001ghl.2_Missense_Mutation_p.V396L|FMO1_uc001ghm.2_Missense_Mutation_p.V396L|FMO1_uc001ghn.2_Intron	NM_002021	NP_002012	Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	396					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TCCTACAGGTGTAAATAAGTT	0.358			NA											32	77					1.61788e-16	2.51004e-16	0.002445	1	0
PAPPA2	60676	broad.mit.edu	37	1	176526271	176526271	+	Silent	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:176526271G>T	uc001gkz.2	+	2	1977	c.813G>T	c.(811-813)CGG>CGT	p.R271R	PAPPA2_uc001gky.1_Silent_p.R271R|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	271					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GGCGGGAGCGGCTGCTGCTGC	0.567			NA											16	44					4.7546e-09	6.34508e-09	0.004007	1	0
PAPPA2	60676	broad.mit.edu	37	1	176679280	176679280	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:176679280G>T	uc001gkz.2	+	11	4783	c.3619G>T	c.(3619-3621)GTT>TTT	p.V1207F	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1207					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GAAGTGTCCTGTTTCCTTGGT	0.463			NA											42	81					1.8453e-21	3.05121e-21	0.002522	1	0
ASTN1	460	broad.mit.edu	37	1	176915112	176915112	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:176915112G>C	uc001glc.2	-	13	2411	c.2199C>G	c.(2197-2199)AAC>AAG	p.N733K	ASTN1_uc001glb.1_Missense_Mutation_p.N733K|ASTN1_uc001gld.1_Missense_Mutation_p.N733K|ASTN1_uc009wwx.1_Missense_Mutation_p.N733K	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	741					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TGGAATGGTTGTTGTAACCAA	0.483			NA											51	164					0	0	0.00361	0	0
FAM5B	57795	broad.mit.edu	37	1	177250467	177250467	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:177250467C>G	uc001glf.2	+	8	2467	c.2155C>G	c.(2155-2157)CAG>GAG	p.Q719E	FAM5B_uc001glg.2_Missense_Mutation_p.Q614E	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	719						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						TGCACTCTTGCAGCTCATTGA	0.542			NA											23	162					0	0	0.003954	0	0
CACNA1E	777	broad.mit.edu	37	1	181741334	181741334	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:181741334C>A	uc001gow.2	+	37	5271	c.5106C>A	c.(5104-5106)TAC>TAA	p.Y1702*	CACNA1E_uc009wxs.2_Nonsense_Mutation_p.Y1590*|CACNA1E_uc001gox.1_Nonsense_Mutation_p.Y928*|CACNA1E_uc009wxt.2_Nonsense_Mutation_p.Y928*	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1702	IV.|Helical; Name=S6 of repeat IV.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CCTACGTGTACTTTGTCTCCT	0.547			NA											36	134					4.62619e-21	7.63271e-21	0.004289	1	0
LAMC1	3915	broad.mit.edu	37	1	183093904	183093904	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:183093904G>C	uc001gpy.3	+	14	2797	c.2540G>C	c.(2539-2541)GGA>GCA	p.G847A		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	847	Laminin EGF-like 8.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGCTTGACGGGAGAATGCCTG	0.517			NA											15	47					0	0	0.003163	0	0
TPR	7175	broad.mit.edu	37	1	186287604	186287604	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:186287604C>T	uc001grv.2	-	48	7093	c.6796G>A	c.(6796-6798)GTA>ATA	p.V2266I		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	2266					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TCCACAAATACTTCATCTCCA	0.388			NA	T	NTRK1	papillary thyroid								6	211					0	0	0.001168	0	0
PTGS2	5743	broad.mit.edu	37	1	186645624	186645624	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:186645624G>T	uc001gsb.2	-	7	1082	c.945C>A	c.(943-945)TTC>TTA	p.F315L	PTGS2_uc009wyo.2_Missense_Mutation_p.F162L	NM_000963	NP_000954	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 precursor	315					cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|central_nervous_system(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	TGCTTGTCTGGAACAACTGCT	0.423			NA											38	160					1.58521e-26	2.69807e-26	0.005524	1	0
PTGS2	5743	broad.mit.edu	37	1	186645994	186645994	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:186645994G>T	uc001gsb.2	-	6	831	c.694C>A	c.(694-696)CTT>ATT	p.L232I	PTGS2_uc009wyo.2_Missense_Mutation_p.L79I	NM_000963	NP_000954	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 precursor	232					cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|central_nervous_system(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	TCCTTGAAAAGGCGCAGTTTA	0.318			NA											59	202					4.45325e-31	7.68365e-31	0.00361	1	0
RGS1	5996	broad.mit.edu	37	1	192544947	192544947	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:192544947C>G	uc001gsi.1	+	1	91	c.25C>G	c.(25-27)CCA>GCA	p.P9A	RGS1_uc010pou.1_Missense_Mutation_p.P9A	NM_002922	NP_002913	Q08116	RGS1_HUMAN	regulator of G-protein signalling 1	9					immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity				0		Breast(1374;0.188)				CATCTCCACTCCAAAGTTAGA	0.443			NA											11	84					0	0	0.008291	0	0
CACNA1S	779	broad.mit.edu	37	1	201009108	201009108	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:201009108C>G	uc001gvv.2	-	44	5700	c.5473G>C	c.(5473-5475)GTG>CTG	p.V1825L		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1825	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ATGATCTCCACTTCCTCTGGT	0.612			NA											38	140					0	0	0.006999	0	0
TMCC2	9911	broad.mit.edu	37	1	205210770	205210770	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:205210770C>A	uc001hbz.1	+	3	789	c.345C>A	c.(343-345)TCC>TCA	p.S115S	TMCC2_uc010prf.1_Silent_p.S37S	NM_014858	NP_055673	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	115						integral to membrane	protein binding			pancreas(1)	1	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			AGGGTATGTCCGACCATGACT	0.637			NA											14	35					0.000151284	0.000172049	0.001855	1	0
INTS7	25896	broad.mit.edu	37	1	212193585	212193585	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:212193585G>C	uc001hiw.1	-	3	355	c.250C>G	c.(250-252)CTT>GTT	p.L84V	INTS7_uc009xdb.1_Missense_Mutation_p.L84V|INTS7_uc001hix.1_5'UTR|INTS7_uc001hiy.1_Missense_Mutation_p.L84V|INTS7_uc010pta.1_Intron	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	84					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		GTAACTTTAAGAACACATAGC	0.294			NA											5	26					0	0	0.001168	0	0
USH2A	7399	broad.mit.edu	37	1	215848172	215848172	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:215848172G>T	uc001hku.1	-	63	13468	c.13081C>A	c.(13081-13083)CCT>ACT	p.P4361T		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4361	Extracellular (Potential).|Fibronectin type-III 29.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGATCTGGAGGGCTGACTTCT	0.488			NA								HNSCC(13;0.011)			18	50					8.28177e-16	1.26662e-15	0.007413	1	0
USH2A	7399	broad.mit.edu	37	1	216465522	216465522	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:216465522G>A	uc001hku.1	-	10	2222	c.1835C>T	c.(1834-1836)ACT>ATT	p.T612I	USH2A_uc001hkv.2_Missense_Mutation_p.T612I	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	612	Laminin EGF-like 2.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTTACCTGTAGTGTTATGCTC	0.383			NA								HNSCC(13;0.011)			33	121					0	0	0.002445	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232577060	232577060	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:232577060C>A	uc001hvg.2	-	12	3777	c.3619G>T	c.(3619-3621)GAT>TAT	p.D1207Y	SIPA1L2_uc001hvf.2_Missense_Mutation_p.D281Y	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1207					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TTGGGGGAATCTTTGCAACTT	0.468			NA											106	413					8.74965e-44	1.53782e-43	0.00361	1	0
LYST	1130	broad.mit.edu	37	1	235883977	235883977	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:235883977C>G	uc001hxj.2	-	40	9719	c.9544G>C	c.(9544-9546)GAT>CAT	p.D3182H	LYST_uc001hxi.2_Missense_Mutation_p.D406H	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3182	BEACH.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			ATCAACAGATCATTGAGGTCA	0.338			NA							Chediak-Higashsyndrome				12	124					0	0	0.001368	0	0
NID1	4811	broad.mit.edu	37	1	236187502	236187502	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:236187502C>A	uc001hxo.2	-	9	2098	c.1996G>T	c.(1996-1998)GAT>TAT	p.D666Y	NID1_uc009xgd.2_Missense_Mutation_p.D666Y	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	666	Nidogen G2 beta-barrel.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	TGAAGAGCATCAGGGGAGCCT	0.547			NA											8	52					0.000274275	0.000303231	0.004482	1	0
RYR2	6262	broad.mit.edu	37	1	237494244	237494244	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:237494244C>A	uc001hyl.1	+	3	355	c.235C>A	c.(235-237)CAG>AAG	p.Q79K		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	79	Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CCGGGCGCTGCAGGAGATGCT	0.502			NA											19	65					0.000229342	0.000258095	0.001882	1	0
RYR2	6262	broad.mit.edu	37	1	237880535	237880535	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:237880535G>A	uc001hyl.1	+	72	10481	c.10361G>A	c.(10360-10362)CGC>CAC	p.R3454H	RYR2_uc010pxz.1_Missense_Mutation_p.R409H	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3454					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAAATGAAGCGCAAAGGAGAT	0.488			NA											12	20					0	0	0.000978	0	0
ZP4	57829	broad.mit.edu	37	1	238051727	238051727	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:238051727C>A	uc001hym.2	-	4	484	c.484G>T	c.(484-486)GGA>TGA	p.G162*	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	162	P-type.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TCACAGTCTCCTCGAGAGATG	0.507	NSCLC(166;160 2029 11600 18754 19936)		NA											24	73					5.35356e-11	7.54501e-11	0.00278	1	0
GREM2	64388	broad.mit.edu	37	1	240656527	240656527	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:240656527G>T	uc001hys.2	-	2	529	c.249C>A	c.(247-249)AGC>AGA	p.S83R		NM_022469	NP_071914	Q9H772	GREM2_HUMAN	gremlin 2 precursor	83	CTCK.				BMP signaling pathway	extracellular space	cytokine activity				0		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)			AGCCCTCCTCGCTCACCGTCT	0.647			NA											9	102					3.86212e-05	4.48006e-05	0.008291	1	0
EXO1	9156	broad.mit.edu	37	1	242035504	242035504	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:242035504A>T	uc001hzh.2	+	12	1978	c.1438A>T	c.(1438-1440)AGA>TGA	p.R480*	EXO1_uc001hzi.2_Nonsense_Mutation_p.R480*|EXO1_uc001hzj.2_Nonsense_Mutation_p.R480*|EXO1_uc009xgq.2_Nonsense_Mutation_p.R479*	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	480	Interaction with MLH1.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			ACCTAGGACGAGAAATAAATT	0.398			NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					28	119					0	0	0.004656	0	0
CEP170	9859	broad.mit.edu	37	1	243327772	243327772	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:243327772G>A	uc001hzs.2	-	13	3898	c.3490C>T	c.(3490-3492)CGT>TGT	p.R1164C	CEP170_uc001hzt.2_Missense_Mutation_p.R1066C|CEP170_uc001hzu.2_Missense_Mutation_p.R1066C|CEP170_uc001hzv.1_Missense_Mutation_p.R542C	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	1164	Targeting to microtubules.|Targeting to centrosomes.					centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			GAGTCACTACGAGCTGACAGT	0.458			NA											6	39					0	0	0.001368	0	0
SDCCAG8	10806	broad.mit.edu	37	1	243652359	243652359	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:243652359C>G	uc001hzw.2	+	17	2185	c.2029C>G	c.(2029-2031)CTG>GTG	p.L677V	SDCCAG8_uc010pyk.1_Missense_Mutation_p.L532V|SDCCAG8_uc010pyl.1_Missense_Mutation_p.L489V|SDCCAG8_uc001hzx.2_Missense_Mutation_p.L410V|AKT3_uc001hzz.1_Intron	NM_006642	NP_006633	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	677	Mediates interaction with OFD1.|Gln-rich.|Potential.|Sufficient for homodimerization (By similarity).				establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding				0	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		AGCCCAGCAGCTGGTGCAGCT	0.587			NA											4	41					0	0	0.001168	0	0
ADSS	159	broad.mit.edu	37	1	244574692	244574692	+	Silent	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:244574692G>A	uc001iaj.2	-	12	1509	c.1215C>T	c.(1213-1215)CTC>CTT	p.L405L		NM_001126	NP_001117	P30520	PURA2_HUMAN	adenylosuccinate synthase	405					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol|plasma membrane	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(2)|kidney(1)	3	all_cancers(71;2.17e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)	all_cancers(173;0.0896)|all_epithelial(177;0.172)	all cancers(7;9.71e-08)|GBM - Glioblastoma multiforme(7;1.28e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.0014)		L-Aspartic Acid(DB00128)	TCCATCCTGGGAGAGTCTTAT	0.343			NA											18	167					0	0	0.006122	0	0
ZNF496	84838	broad.mit.edu	37	1	247463969	247463969	+	Missense_Mutation	SNP	C	C	A	rs144745098		TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:247463969C>A	uc001ico.2	-	9	2081	c.1616G>T	c.(1615-1617)CGG>CTG	p.R539L	ZNF496_uc009xgv.2_Missense_Mutation_p.R575L|ZNF496_uc001icp.2_Missense_Mutation_p.R539L	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	539	C2H2-type 4.				positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			GCTGCGGTGCCGAGCCAGGTG	0.612			NA											13	119					4.36969e-10	5.95795e-10	0.001855	1	0
NLRP3	114548	broad.mit.edu	37	1	247582226	247582226	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:247582226G>T	uc001icr.2	+	3	268	c.130G>T	c.(130-132)GGT>TGT	p.G44C	NLRP3_uc001ics.2_Missense_Mutation_p.G44C|NLRP3_uc001icu.2_Missense_Mutation_p.G44C|NLRP3_uc001icw.2_Missense_Mutation_p.G44C|NLRP3_uc001icv.2_Missense_Mutation_p.G44C|NLRP3_uc010pyw.1_Missense_Mutation_p.G42C|NLRP3_uc001ict.1_Missense_Mutation_p.G42C	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	44	DAPIN.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CCTCCCGAGGGGTCAGACAGA	0.567			NA											8	47					0.000157383	0.000177645	0.00308	1	0
TRIM58	25893	broad.mit.edu	37	1	248039487	248039487	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:248039487T>A	uc001ido.2	+	6	1205	c.1157T>A	c.(1156-1158)CTG>CAG	p.L386Q	OR2W3_uc001idp.1_Intron	NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	386	B30.2/SPRY.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GCCCTGTGGCTGCTGAAAGGG	0.547			NA											68	113					0	0	0.00361	0	0
OR2M5	127059	broad.mit.edu	37	1	248308625	248308625	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:248308625T>C	uc010pze.1	+	1	176	c.176T>C	c.(175-177)ATG>ACG	p.M59T		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	59	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			CACACCCCCATGTACTTCCTC	0.512			NA											55	545					0	0	0.00361	0	0
OR2T4	127074	broad.mit.edu	37	1	248525180	248525180	+	Missense_Mutation	SNP	C	C	T	rs142091573	byFrequency	TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:248525180C>T	uc001ieh.1	+	1	298	c.298C>T	c.(298-300)CTC>TTC	p.L100F		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	100	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCAATTGTCTCTCATGGACAT	0.502			NA											23	323					0	0	0.001882	0	0
SFMBT2	57713	broad.mit.edu	37	10	7262394	7262394	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:7262394G>T	uc009xio.1	-	11	1400	c.1309C>A	c.(1309-1311)CTA>ATA	p.L437I	SFMBT2_uc001ijn.1_Missense_Mutation_p.L437I|SFMBT2_uc010qay.1_Intron	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	437	MBT 4.				regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						AGCCACATTAGCCGCCCCTTC	0.532			NA											41	228					1.59932e-28	2.73444e-28	0.007835	1	0
TAF3	83860	broad.mit.edu	37	10	8007650	8007650	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:8007650A>G	uc010qbd.1	+	3	2177	c.2177A>G	c.(2176-2178)GAG>GGG	p.E726G		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	726	Lys-rich.				maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						agagagaaagagaagagagag	0.119			NA											9	36					0	0	0.004482	0	0
FAM171A1	221061	broad.mit.edu	37	10	15256244	15256244	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:15256244G>T	uc001iob.2	-	8	1350	c.1343C>A	c.(1342-1344)ACT>AAT	p.T448N		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	448	Cytoplasmic (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						CCCACTTGGAGTGAGGTTATC	0.502			NA											9	63					0.00448238	0.00474679	0.004482	1	0
ARHGAP21	57584	broad.mit.edu	37	10	24878202	24878202	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:24878202T>C	uc001isb.2	-	25	4667	c.4180A>G	c.(4180-4182)AAG>GAG	p.K1394E	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1393					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						CAATTTACCTTAGATTTTGTT	0.318			NA											18	49					0	0	0.010504	0	0
GPR158	57512	broad.mit.edu	37	10	25887785	25887785	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:25887785A>C	uc001isj.2	+	11	3290	c.3230A>C	c.(3229-3231)CAA>CCA	p.Q1077P	GPR158_uc001isk.2_Missense_Mutation_p.Q452P	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	1077	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						TGGGAGAGCCAAGGCCAGTCC	0.493			NA											24	109					0	0	0.004656	0	0
GPR158	57512	broad.mit.edu	37	10	25887787	25887787	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:25887787G>C	uc001isj.2	+	11	3292	c.3232G>C	c.(3232-3234)GGC>CGC	p.G1078R	GPR158_uc001isk.2_Missense_Mutation_p.G453R	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	1078	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GGAGAGCCAAGGCCAGTCCAT	0.493			NA											24	109					0	0	0.005443	0	0
GAD2	2572	broad.mit.edu	37	10	26558096	26558096	+	Silent	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:26558096A>G	uc001isp.2	+	9	1472	c.969A>G	c.(967-969)AAA>AAG	p.K323K	GAD2_uc001isq.2_Silent_p.K323K	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	323					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	TTGAAGCCAAACAGAAAGTAA	0.358			NA											15	68					0	0	0.00499	0	0
ACBD5	91452	broad.mit.edu	37	10	27497332	27497332	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:27497332T>A	uc010qdp.1	-	10	1438	c.1247A>T	c.(1246-1248)CAG>CTG	p.Q416L	ACBD5_uc010qdm.1_Missense_Mutation_p.Q414L|ACBD5_uc010qdn.1_Missense_Mutation_p.Q307L|ACBD5_uc010qdo.1_Missense_Mutation_p.Q239L|ACBD5_uc001ito.2_Missense_Mutation_p.Q381L|ACBD5_uc001itp.2_Missense_Mutation_p.Q307L|ACBD5_uc001itq.2_Missense_Mutation_p.Q307L|ACBD5_uc001itr.1_Missense_Mutation_p.Q205L	NM_145698	NP_663736	Q5T8D3	ACBD5_HUMAN	acyl-Coenzyme A binding domain containing 5	425					transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding				0						ACTTCCCACCTGCCGGCCCTT	0.507			NA											29	56					0	0	0.009535	0	0
WAC	51322	broad.mit.edu	37	10	28884908	28884908	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:28884908C>G	uc001iuf.2	+	7	942	c.857C>G	c.(856-858)TCT>TGT	p.S286C	WAC_uc001iud.2_Missense_Mutation_p.S241C|WAC_uc001iue.2_Intron|WAC_uc009xlb.2_Missense_Mutation_p.S241C|WAC_uc001iug.2_Intron|WAC_uc001iuh.2_Missense_Mutation_p.S241C	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil	286					cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2						AATGGAGCATCTACTTTATCA	0.423			NA											29	85					0	0	0.00632	0	0
ZEB1	6935	broad.mit.edu	37	10	31815707	31815707	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:31815707A>T	uc001ivs.3	+	9	2953	c.2890A>T	c.(2890-2892)AAA>TAA	p.K964*	ZEB1_uc001ivr.3_Nonsense_Mutation_p.K746*|ZEB1_uc010qee.1_Nonsense_Mutation_p.K746*|ZEB1_uc010qef.1_Nonsense_Mutation_p.K746*|ZEB1_uc001ivt.3_Nonsense_Mutation_p.K746*|ZEB1_uc001ivu.3_Nonsense_Mutation_p.K965*|ZEB1_uc001ivv.3_Nonsense_Mutation_p.K944*|ZEB1_uc010qeh.1_Nonsense_Mutation_p.K897*|ZEB1_uc009xlp.2_Nonsense_Mutation_p.K948*	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	964	C2H2-type 7; atypical.				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				TCAATGTGACAAATGTGGAAA	0.413	Ovarian(40;423 959 14296 36701 49589)		NA											12	54					0	0	0.000978	0	0
EPC1	80314	broad.mit.edu	37	10	32594782	32594782	+	Silent	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:32594782T>A	uc001iwg.1	-	2	501	c.231A>T	c.(229-231)CCA>CCT	p.P77P	EPC1_uc001iwi.3_Silent_p.P27P|EPC1_uc009xlt.2_Silent_p.P27P|EPC1_uc001iwh.1_Silent_p.P77P	NM_025209	NP_079485	Q9H2F5	EPC1_HUMAN	enhancer of polycomb 1	77					histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				ovary(3)|central_nervous_system(1)	4		Prostate(175;0.0199)				TTTCTGCCTCTGGGACCGGTA	0.403			NA											17	43					0	0	0.00499	0	0
ZNF33A	7581	broad.mit.edu	37	10	38344699	38344699	+	Silent	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:38344699G>A	uc001izh.2	+	5	1822	c.1644G>A	c.(1642-1644)GGG>GGA	p.G548G	ZNF33A_uc001izg.2_Silent_p.G549G|ZNF33A_uc010qev.1_Silent_p.G555G|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	548						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						CACACACAGGGCAGAAACCCT	0.428			NA											10	127					0	0	0.000978	0	0
BMS1	9790	broad.mit.edu	37	10	43326451	43326451	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:43326451G>C	uc001jaj.2	+	23	4114	c.3756G>C	c.(3754-3756)AAG>AAC	p.K1252N		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	1252					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						AGCGGCAGAAGGACCTCAGGA	0.527			NA											4	16					0	0	0.001168	0	0
CSGALNACT2	55454	broad.mit.edu	37	10	43678731	43678731	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:43678731G>C	uc001jan.2	+	8	1705	c.1370G>C	c.(1369-1371)GGA>GCA	p.G457A		NM_018590	NP_061060	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate	457	Lumenal (Potential).				chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			ovary(1)	1						GGTTGGGGTGGAGAAGATGTT	0.408			NA											24	164					0	0	0.004656	0	0
DRGX	644168	broad.mit.edu	37	10	50594820	50594820	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:50594820C>A	uc010qgq.1	-	4	334	c.334G>T	c.(334-336)GCA>TCA	p.A112S		NM_001080520	NP_001073989	A6NNA5	DRGX_HUMAN	dorsal root ganglia homeobox	112					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GTCACCTCTGCCATGGGCTCC	0.607			NA											32	93					1.45844e-13	2.16469e-13	0.002836	1	0
PRKG1	5592	broad.mit.edu	37	10	54041979	54041979	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:54041979G>T	uc001jjm.2	+	14	1761	c.1567G>T	c.(1567-1569)GAG>TAG	p.E523*	PRKG1_uc001jjo.2_Nonsense_Mutation_p.E538*|PRKG1_uc009xow.1_Nonsense_Mutation_p.E241*|uc001jjq.1_Intron	NM_001098512	NP_001091982	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I isoform	523	Protein kinase.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		TGGGACTCCAGAGTATGTAGC	0.418			NA											30	44					3.1745e-13	4.66583e-13	0.008361	1	0
RUFY2	55680	broad.mit.edu	37	10	70123383	70123383	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:70123383T>C	uc001job.2	-	15	1946	c.1619A>G	c.(1618-1620)GAG>GGG	p.E540G	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joa.2_Missense_Mutation_p.E95G	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	554	Potential.					nucleus	metal ion binding			ovary(1)	1						AAGAGCTTGCTCTTGTTCATG	0.328			NA											5	14					0	0	0.001168	0	0
PTEN	5728	broad.mit.edu	37	10	89653807	89653807	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:89653807G>T	uc001kfb.2	+	3	1136	c.105G>T	c.(103-105)ATG>ATT	p.M35I		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	35	Phosphatase tensin-type.		M -> R (in CD).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.?(4)|p.Y27fs*1(2)|p.M35V(2)|p.Y27_N212>Y(2)|p.A34_G36del(1)|p.M35R(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TTATTGCTATGGGATTTCCTG	0.284			31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			18	51					2.48551e-13	3.66029e-13	0.00499	1	0
MYOF	26509	broad.mit.edu	37	10	95168668	95168668	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:95168668C>T	uc001kin.2	-	7	728	c.605G>A	c.(604-606)CGC>CAC	p.R202H	MYOF_uc001kio.2_Missense_Mutation_p.R202H|MYOF_uc001kip.3_Missense_Mutation_p.R202H|MYOF_uc009xuf.2_Missense_Mutation_p.R184H	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	202	C2 2.|Cytoplasmic (Potential).|Necessary for interaction with EHD2.				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						CACTCGGACGCGGATCTGCAG	0.507			NA											10	79					0	0	0.000978	0	0
POLL	27343	broad.mit.edu	37	10	103345895	103345895	+	Missense_Mutation	SNP	C	C	A	rs141683033	byFrequency	TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:103345895C>A	uc001ktg.1	-	2	900	c.134G>T	c.(133-135)CGG>CTG	p.R45L	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_5'Flank|POLL_uc001kte.1_5'Flank|POLL_uc001kth.1_Intron|POLL_uc001kti.1_Missense_Mutation_p.R45L|POLL_uc001ktj.1_Missense_Mutation_p.R45L|POLL_uc001ktf.2_Missense_Mutation_p.R45L|POLL_uc001ktk.1_Intron|POLL_uc010qqa.1_Intron|POLL_uc010qqb.1_Intron|POLL_uc001ktm.2_Missense_Mutation_p.R45L|POLL_uc001ktl.2_5'UTR|POLL_uc010qqc.1_5'UTR|POLL_uc010qqd.1_5'UTR|DPCD_uc001ktn.2_5'Flank	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	45	BRCT.				DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		AACATGGGCCCGAAGGGAGCT	0.537			NA						DNA_polymerases_(catalytic_subunits)					7	43					0.000673444	0.000735908	0.008291	1	0
PPRC1	23082	broad.mit.edu	37	10	103906433	103906433	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:103906433C>T	uc001kum.2	+	9	3723	c.3684C>T	c.(3682-3684)CTC>CTT	p.L1228L	PPRC1_uc001kun.2_Silent_p.L1108L|PPRC1_uc010qqj.1_Intron|PPRC1_uc009xxa.2_Intron	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	1228					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CCACAGGGCTCACCCCTCCAG	0.577			NA											36	93					0	0	0.007835	0	0
PDCD11	22984	broad.mit.edu	37	10	105158243	105158243	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:105158243G>C	uc001kwy.1	+	2	147	c.60G>C	c.(58-60)GAG>GAC	p.E20D	USMG5_uc001kww.1_5'Flank|USMG5_uc001kwx.1_5'Flank	NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	20					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		ACAAACCAGAGAAAGCTTTCC	0.418			NA											8	37					0	0	0.00308	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105365611	105365611	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:105365611C>A	uc001kxj.1	-	13	1428	c.1288G>T	c.(1288-1290)GAA>TAA	p.E430*	SH3PXD2A_uc010qqr.1_Intron|SH3PXD2A_uc010qqs.1_Nonsense_Mutation_p.E265*|SH3PXD2A_uc010qqt.1_Nonsense_Mutation_p.E307*|SH3PXD2A_uc009xxn.1_Nonsense_Mutation_p.E265*|SH3PXD2A_uc010qqu.1_Nonsense_Mutation_p.E373*	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	458	SH3 3.				cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		GACTGGAATTCGGCAATGGTG	0.542			NA									OREG0020500	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	44					1.01871e-10	1.42771e-10	0.008871	1	0
SORCS1	114815	broad.mit.edu	37	10	108366923	108366923	+	Splice_Site	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:108366923C>A	uc001kym.2	-	23	3173	c.3165_splice	c.e23+1	p.Q1055_splice	SORCS1_uc001kyl.2_Splice_Site_p.Q1055_splice|SORCS1_uc009xxs.2_Splice_Site_p.Q1055_splice|SORCS1_uc001kyn.1_Splice_Site_p.Q1055_splice|SORCS1_uc001kyo.2_Splice_Site_p.Q1055_splice	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a							integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AGGGGACTCACCTGCTCCAGG	0.498			NA											7	50					8.12818e-05	9.28583e-05	0.001984	1	0
ADRA2A	150	broad.mit.edu	37	10	112838897	112838897	+	Silent	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:112838897G>A	uc001kzo.2	+	1	2108	c.1143G>A	c.(1141-1143)CAG>CAA	p.Q381Q		NM_000681	NP_000672	P08913	ADA2A_HUMAN	alpha-2A-adrenergic receptor	366	Cytoplasmic (By similarity).				actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding				0		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	GCGGGCGGCAGAACCGCGAGA	0.632	Esophageal Squamous(173;605 2658 7278 49362)		NA											27	138					0	0	0.005443	0	0
ACSL5	51703	broad.mit.edu	37	10	114164554	114164554	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:114164554A>G	uc001kzs.2	+	5	563	c.422A>G	c.(421-423)AAT>AGT	p.N141S	ACSL5_uc001kzt.2_Missense_Mutation_p.N141S|ACSL5_uc001kzu.2_Missense_Mutation_p.N197S|ACSL5_uc009xxz.2_Missense_Mutation_p.N141S	NM_203379	NP_976313	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	141	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(2)|skin(1)	3		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		TTTGCTCAGAATAGGCCAGAG	0.408			NA											28	136					0	0	0.005443	0	0
ZDHHC6	64429	broad.mit.edu	37	10	114203279	114203279	+	Missense_Mutation	SNP	C	C	T	rs141897265		TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:114203279C>T	uc001kzv.2	-	3	777	c.353G>A	c.(352-354)TGT>TAT	p.C118Y	ZDHHC6_uc001kzw.2_Missense_Mutation_p.C114Y|ZDHHC6_uc009xya.1_Missense_Mutation_p.C118Y	NM_022494	NP_071939	Q9H6R6	ZDHC6_HUMAN	zinc finger, DHHC-type containing 6	118	DHHC-type.					integral to membrane	acyltransferase activity|zinc ion binding				0		Colorectal(252;0.198)		Epithelial(162;0.0291)|all cancers(201;0.117)		GTACCTGTTACACTTTCTGCA	0.403			NA											10	130					0	0	0.008291	0	0
NRAP	4892	broad.mit.edu	37	10	115409891	115409891	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:115409891G>T	uc001laj.2	-	9	957	c.793C>A	c.(793-795)CAT>AAT	p.H265N	NRAP_uc001lak.2_Missense_Mutation_p.H265N|NRAP_uc001lal.3_Missense_Mutation_p.H265N	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	265	Nebulin 5.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TATTGTTGATGGTACCTCACC	0.443			NA											35	200					1.30015e-28	2.23306e-28	0.004878	1	0
PNLIP	5406	broad.mit.edu	37	10	118315520	118315520	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:118315520G>C	uc001lcm.2	+	9	863	c.820G>C	c.(820-822)GAC>CAC	p.D274H		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	274					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	AGGGACTCGAGACTTTGCGGC	0.393			NA											19	125					0	0	0.008871	0	0
DMBT1	1755	broad.mit.edu	37	10	124402858	124402858	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr10:124402858G>A	uc001lgk.1	+	53	7292	c.7186G>A	c.(7186-7188)GTC>ATC	p.V2396I	DMBT1_uc001lgl.1_Missense_Mutation_p.V2386I|DMBT1_uc001lgm.1_Missense_Mutation_p.V1768I|DMBT1_uc009xzz.1_Missense_Mutation_p.V2395I|DMBT1_uc010qtx.1_Missense_Mutation_p.V1116I|DMBT1_uc009yab.1_Missense_Mutation_p.V1099I|DMBT1_uc009yac.1_Missense_Mutation_p.V690I	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2396					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GGTGGACGTCGTCCTGGGTCC	0.647	Ovarian(182;93 2026 18125 22222 38972)		NA											18	32					0	0	0.00499	0	0
CD151	977	broad.mit.edu	37	11	838021	838021	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:838021G>T	uc001lry.2	+	8	839	c.695G>T	c.(694-696)TGT>TTT	p.C232F	CD151_uc001lrx.2_RNA|CD151_uc001lrz.2_Missense_Mutation_p.C232F|CD151_uc001lsa.2_Missense_Mutation_p.C232F|CD151_uc001lsb.2_Missense_Mutation_p.C232F	NM_004357	NP_004348	P48509	CD151_HUMAN	CD151 antigen	232	Helical; (Potential).				cell adhesion|hemidesmosome assembly	cytosol|integral to plasma membrane|membrane fraction	protein binding				0		all_cancers(49;2.31e-08)|all_epithelial(84;3.72e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.179)|all_lung(207;0.227)		all cancers(45;1.54e-25)|Epithelial(43;1.22e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.91e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGCATTGCCTGTGTGCAGGTG	0.667	Esophageal Squamous(14;501 559 15826 37823 38305)		NA											7	19					8.12818e-05	9.28583e-05	0.001984	1	0
MUC2	4583	broad.mit.edu	37	11	1090835	1090835	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:1090835G>T	uc001lsx.1	+	28	3757	c.3730G>T	c.(3730-3732)GGC>TGC	p.G1244C		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	1244						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GGAGATCTGTGGCCCCAACGG	0.463			NA											12	28					7.03913e-09	9.36067e-09	0.001368	1	0
MUC5B	727897	broad.mit.edu	37	11	1267460	1267460	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:1267460G>A	uc009ycr.1	+	49	11225	c.11099G>A	c.(11098-11100)AGG>AAG	p.R3700K	MUC5B_uc001ltb.2_Missense_Mutation_p.R3120K	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3117	7 X Cys-rich subdomain repeats.|Thr-rich.|17 X approximate tandem repeats, Ser/Thr- rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACCACGACAAGGGCCACCAGT	0.637			NA											21	84					0	0	0.010504	0	0
LSP1	4046	broad.mit.edu	37	11	1908785	1908785	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:1908785G>T	uc001lui.2	+	10	1187	c.1012G>T	c.(1012-1014)GCT>TCT	p.A338S	LSP1_uc001luj.2_Missense_Mutation_p.A466S|LSP1_uc001luk.2_Missense_Mutation_p.A276S|LSP1_uc001lul.2_Missense_Mutation_p.A276S|LSP1_uc001lum.2_Missense_Mutation_p.A276S	NM_002339	NP_002330	P33241	LSP1_HUMAN	lymphocyte-specific protein 1 isoform 1	338					cellular component movement|cellular defense response	actin cytoskeleton|Golgi apparatus|plasma membrane	actin binding|signal transducer activity			large_intestine(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|Lung(200;0.0729)|LUSC - Lung squamous cell carcinoma(625;0.0856)		AGGGGGCCCGGCTCCCTAGGC	0.592			NA											6	28					5.9392e-07	7.40191e-07	0.001168	1	0
IGF2	3481	broad.mit.edu	37	11	2154386	2154386	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:2154386C>A	uc009yde.2	-	4	477	c.374G>T	c.(373-375)CGC>CTC	p.R125L	IGF2_uc001lvf.2_RNA|IGF2_uc001lvg.2_Missense_Mutation_p.R125L|IGF2_uc009ydf.2_Missense_Mutation_p.R181L|IGF2_uc001lvh.2_Missense_Mutation_p.R125L|INS-IGF2_uc001lvi.2_RNA	NM_001007139	NP_001007140	P01344	IGF2_HUMAN	insulin-like growth factor 2 isoform 1	125					glucose metabolic process|ossification|phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling|positive regulation of activated T cell proliferation|positive regulation of cell division|positive regulation of glycogen (starch) synthase activity|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|skeletal system development	extracellular space	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|protein serine/threonine kinase activator activity|receptor activator activity			central_nervous_system(1)	1		all_epithelial(84;5.04e-06)|Breast(177;0.000777)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)	Colorectal(5;0.0179)|COAD - Colon adenocarcinoma(6;0.029)	BRCA - Breast invasive adenocarcinoma(625;1.09e-05)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		CCTGCGCAGGCGCTGGGTGGA	0.667			NA											6	16					0.00116845	0.00125679	0.001168	1	0
OR51V1	283111	broad.mit.edu	37	11	5221326	5221326	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:5221326C>A	uc010qyz.1	-	1	605	c.605G>T	c.(604-606)CGA>CTA	p.R202L		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	202	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACTATTGAATCGGATGTCTGA	0.408			NA											17	42					0.000958276	0.00104564	0.007413	1	0
OR52N2	390077	broad.mit.edu	37	11	5841791	5841791	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:5841791T>A	uc010qzp.1	+	1	226	c.226T>A	c.(226-228)TGC>AGC	p.C76S	TRIM5_uc001mbq.1_Intron	NM_001005174	NP_001005174	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N,	76	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTCACCTTGTGCACCACCAT	0.527			NA											35	112					0	0	0.004878	0	0
DNHD1	144132	broad.mit.edu	37	11	6524146	6524146	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:6524146C>T	uc001mdw.3	+	4	1474	c.910C>T	c.(910-912)CGG>TGG	p.R304W	DNHD1_uc001mdp.2_Missense_Mutation_p.R304W	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	304					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GGCTCCCAGCCGGTACTTTAG	0.323			NA											17	32					0	0	0.006122	0	0
SOX6	55553	broad.mit.edu	37	11	16208425	16208425	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:16208425C>A	uc001mme.2	-	5	684	c.651G>T	c.(649-651)CAG>CAT	p.Q217H	SOX6_uc001mmd.2_Missense_Mutation_p.Q207H|SOX6_uc001mmf.2_Missense_Mutation_p.Q204H|SOX6_uc001mmg.2_Missense_Mutation_p.Q204H	NM_001145819	NP_001139291	P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6 isoform 4	204	Potential.				muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3						CTGCCAGTAGCTGCTCCCGTA	0.493			NA											63	124					2.20561e-19	3.55349e-19	0.00361	1	0
SLC6A5	9152	broad.mit.edu	37	11	20622838	20622838	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:20622838C>T	uc001mqd.2	+	2	440	c.167C>T	c.(166-168)TCC>TTC	p.S56F	SLC6A5_uc009yic.2_5'UTR	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	56	Cytoplasmic (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	AGGTCCGCTTCCACCGGCGCC	0.736			NA											4	10					0	0	0.000602	0	0
NELL1	4745	broad.mit.edu	37	11	20907087	20907087	+	Splice_Site	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:20907087G>T	uc001mqe.2	+	5	756	c.603_splice	c.e5+1	p.K201_splice	NELL1_uc001mqf.2_Splice_Site_p.K201_splice|NELL1_uc009yid.2_Splice_Site_p.K229_splice|NELL1_uc010rdo.1_Splice_Site_p.K144_splice|NELL1_uc010rdp.1_Intron	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor						cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						CTTATTCAAAGTAAGCACTAA	0.403			NA											9	29					0.000274275	0.000303231	0.004482	1	0
MPPED2	744	broad.mit.edu	37	11	30557678	30557678	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:30557678G>A	uc001msr.2	-	2	293	c.173C>T	c.(172-174)ACG>ATG	p.T58M	MPPED2_uc001msq.3_Missense_Mutation_p.T58M|MPPED2_uc009yji.2_Translation_Start_Site	NM_001584	NP_001575	Q15777	MPPD2_HUMAN	metallophosphoesterase domain containing 2	58					nervous system development		hydrolase activity|metal ion binding			skin(1)	1						GACAAACCGCGTGTGGCCCGC	0.483			NA											4	37					0	0	0.009096	0	0
ABTB2	25841	broad.mit.edu	37	11	34173997	34173997	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:34173997C>T	uc001mvl.1	-	17	2687	c.2457G>A	c.(2455-2457)CTG>CTA	p.L819L		NM_145804	NP_665803	Q8N961	ABTB2_HUMAN	ankyrin repeat and BTB (POZ) domain containing	819							DNA binding			central_nervous_system(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				GCAGGTCCTGCAGTGGATCCA	0.647			NA											4	4					0	0	0.000602	0	0
SYT13	57586	broad.mit.edu	37	11	45268061	45268061	+	Silent	SNP	C	C	T	rs144015985	by1000genomes	TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:45268061C>T	uc001myq.2	-	5	975	c.849G>A	c.(847-849)GAG>GAA	p.E283E	SYT13_uc009yku.1_Silent_p.E139E	NM_020826	NP_065877	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	283	Cytoplasmic (Potential).					transport vesicle				ovary(1)	1						CTGCAGATGGCTCCTGAAACA	0.547			NA											4	19					0	0	0.009096	0	0
LRP4	4038	broad.mit.edu	37	11	46918425	46918425	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:46918425T>C	uc001ndn.3	-	8	1063	c.917A>G	c.(916-918)AAT>AGT	p.N306S		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	306	Extracellular (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		ACCACCTGTATTCTCACAGTT	0.567			NA											10	98					0	0	0.001368	0	0
OR4A5	81318	broad.mit.edu	37	11	51411594	51411594	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:51411594T>C	uc001nhi.1	-	1	802	c.802A>G	c.(802-804)ATG>GTG	p.M268V		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	268	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				AACACAGTCATGAACTTATCA	0.368			NA											11	76					0	0	0.000978	0	0
OR4C15	81309	broad.mit.edu	37	11	55322549	55322549	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:55322549G>T	uc010rig.1	+	1	767	c.767G>T	c.(766-768)AGT>ATT	p.S256I		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GTCATCAACAGTGGGTTTATC	0.473			NA								HNSCC(20;0.049)			8	60					1.06961e-07	1.37861e-07	0.00308	1	0
OR5D13	390142	broad.mit.edu	37	11	55541528	55541528	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:55541528C>A	uc010ril.1	+	1	615	c.615C>A	c.(613-615)GCC>GCA	p.A205A		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	205	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				TTATTATTGCCATATTCAATG	0.383			NA											25	154					0.000586117	0.000643278	0.003954	1	0
OR5M10	390167	broad.mit.edu	37	11	56344535	56344535	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:56344535A>C	uc001niz.1	-	1	663	c.663T>G	c.(661-663)ATT>ATG	p.I221M		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCGCTGCAAAAATGAAAAGAT	0.453			NA											8	85					0	0	0.006214	0	0
OR9G9	504191	broad.mit.edu	37	11	56468325	56468325	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:56468325C>A	uc010rjn.1	+	1	462	c.462C>A	c.(460-462)AAC>AAA	p.N154K		NM_001013358	NP_001013376	P0C7N8	OR9G9_HUMAN	olfactory receptor, family 9, subfamily G,	154	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCTTTATTAACTCTTCAATCA	0.458			NA											12	199					0.000978159	0.00105815	0.000978	1	0
APLNR	187	broad.mit.edu	37	11	57003659	57003659	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:57003659C>T	uc001njo.2	-	1	1269	c.820G>A	c.(820-822)GGC>AGC	p.G274S	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	274	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						AGCAGGCTGCCCAGCATGTAC	0.597			NA											16	30					0	0	0.003163	0	0
OR5B17	219965	broad.mit.edu	37	11	58126193	58126193	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:58126193G>T	uc010rke.1	-	1	350	c.350C>A	c.(349-351)GCC>GAC	p.A117D		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GCGGTCATAGGCCATTGAGGA	0.473			NA											10	90					7.48243e-07	9.21855e-07	0.006214	1	0
OR5B21	219968	broad.mit.edu	37	11	58275105	58275105	+	Silent	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:58275105T>A	uc010rki.1	-	1	474	c.474A>T	c.(472-474)GCA>GCT	p.A158A		NM_001005218	NP_001005218	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AGGTGCCTGCTGCATGGATAG	0.507			NA											8	67					0	0	0.00308	0	0
OR4D10	390197	broad.mit.edu	37	11	59245091	59245091	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:59245091C>A	uc001nnz.1	+	1	189	c.189C>A	c.(187-189)CTC>CTA	p.L63L		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						ATTTTTTGCTCCATAATTTAT	0.443			NA											72	168					5.1178e-15	7.74864e-15	0.00361	1	0
SYT7	9066	broad.mit.edu	37	11	61295529	61295529	+	Missense_Mutation	SNP	C	C	A	rs17849204	by1000genomes	TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:61295529C>A	uc001nrv.2	-	5	486	c.480G>T	c.(478-480)CAG>CAT	p.Q160H	SYT7_uc009ynr.2_Missense_Mutation_p.Q235H	NM_004200	NP_004191	O43581	SYT7_HUMAN	synaptotagmin VII	160	C2 1.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			ovary(3)|pancreas(1)	4						CCGGCAGCTCCTGGGCCTTCA	0.607			NA											52	66					1.35964e-18	2.15825e-18	0.00361	1	0
INCENP	3619	broad.mit.edu	37	11	61898026	61898026	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:61898026A>T	uc001nsw.1	+	4	1229	c.1027A>T	c.(1027-1029)ACT>TCT	p.T343S	INCENP_uc009ynv.2_Missense_Mutation_p.T343S|INCENP_uc009ynw.1_Missense_Mutation_p.T343S|INCENP_uc001nsx.1_Missense_Mutation_p.T343S	NM_001040694	NP_001035784	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	343					chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			lung(1)	1						TGCCAAGAAGACTGCCGAAGA	0.607			NA											11	72					0	0	0.008291	0	0
AHNAK	79026	broad.mit.edu	37	11	62288392	62288392	+	Silent	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:62288392T>C	uc001ntl.2	-	5	13797	c.13497A>G	c.(13495-13497)GAA>GAG	p.E4499E	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4499					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGAGCTTCCCTTCAGGACCTT	0.443			NA											13	105					0	0	0.001368	0	0
AHNAK	79026	broad.mit.edu	37	11	62294707	62294707	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:62294707G>T	uc001ntl.2	-	5	7482	c.7182C>A	c.(7180-7182)CAC>CAA	p.H2394Q	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2394					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GGCTCTTCAAGTGTAGATCGA	0.483			NA											54	72					1.86277e-20	3.05998e-20	0.00361	1	0
UBXN1	51035	broad.mit.edu	37	11	62446030	62446030	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:62446030C>G	uc001nul.1	-	3	289	c.157G>C	c.(157-159)GAG>CAG	p.E53Q	UBXN1_uc001nuj.2_Missense_Mutation_p.E53Q|UBXN1_uc001num.1_Missense_Mutation_p.E53Q|UBXN1_uc001nuk.2_Missense_Mutation_p.E18Q|UBXN1_uc010rme.1_Missense_Mutation_p.E53Q|UBXN1_uc010rmf.1_Missense_Mutation_p.E53Q	NM_015853	NP_056937	Q04323	UBXN1_HUMAN	UBX domain protein 1	53	Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding				0						AGGGGAGTCTCTAAAGGCTCG	0.617			NA											5	92					0	0	0.000602	0	0
PCNXL3	399909	broad.mit.edu	37	11	65387893	65387893	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:65387893G>A	uc001oey.2	+	9	2092	c.2092G>A	c.(2092-2094)GGA>AGA	p.G698R		NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	698						integral to membrane					0						GACAGCTAATGGAGCCTGGTG	0.612			NA											14	29					0	0	0.00245	0	0
NPAS4	266743	broad.mit.edu	37	11	66191660	66191660	+	Silent	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:66191660C>G	uc001ohx.1	+	7	1475	c.1299C>G	c.(1297-1299)GGC>GGG	p.G433G	NPAS4_uc010rpc.1_Silent_p.G223G	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	433					transcription, DNA-dependent		DNA binding|signal transducer activity				0						AGCCAGGAGGCTGTGCCTTCC	0.557			NA											80	160					0	0	0.00361	0	0
DPP3	10072	broad.mit.edu	37	11	66276549	66276549	+	Splice_Site	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:66276549G>T	uc001oig.1	+	18	2104	c.2042_splice	c.e18-1	p.G681_splice	DPP3_uc001oif.1_Splice_Site_p.G681_splice|DPP3_uc010rpe.1_Splice_Site_p.G670_splice|DPP3_uc001oih.1_Splice_Site_p.A49_splice|BBS1_uc001oii.1_5'Flank|BBS1_uc010rpf.1_5'Flank|BBS1_uc010rpg.1_5'Flank|BBS1_uc001oij.1_5'Flank|BBS1_uc001oik.1_5'Flank|BBS1_uc001oil.1_5'Flank	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III						proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						CTCCTCCCCAGGCTCAGACGT	0.488			NA											13	120					9.16793e-09	1.21701e-08	0.00499	1	0
KRTAP5-11	440051	broad.mit.edu	37	11	71293437	71293437	+	Silent	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:71293437G>T	uc001oqu.2	-	1	485	c.447C>A	c.(445-447)CCC>CCA	p.P149P		NM_001005405	NP_001005405	Q6L8G4	KR511_HUMAN	keratin associated protein 5-11	149	6.|6 X 4 AA repeats of C-C-X-P.					keratin filament					0						GGCAGCACACGGGGACAcagc	0.259			NA											21	140					2.27731e-05	2.67043e-05	0.001882	1	0
C2CD3	26005	broad.mit.edu	37	11	73768561	73768561	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:73768561C>A	uc001ouu.2	-	25	5207	c.4980G>T	c.(4978-4980)TCG>TCT	p.S1660S	C2CD3_uc001out.2_RNA	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1660	C2 2.					centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					AACTGGGTATCGATACTTTCC	0.448			NA											20	138					1.64113e-05	1.93346e-05	0.010504	1	0
C11orf30	56946	broad.mit.edu	37	11	76174925	76174925	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:76174925G>T	uc001oxl.2	+	7	775	c.632G>T	c.(631-633)AGC>ATC	p.S211I	C11orf30_uc009yuj.1_Missense_Mutation_p.S226I|C11orf30_uc010rsa.1_Missense_Mutation_p.S161I|C11orf30_uc001oxm.2_Missense_Mutation_p.S212I|C11orf30_uc010rsb.1_Missense_Mutation_p.S226I|C11orf30_uc010rsc.1_Missense_Mutation_p.S226I|C11orf30_uc001oxn.2_Missense_Mutation_p.S212I|C11orf30_uc010rsd.1_Missense_Mutation_p.S225I	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	211	Interaction with BRCA2.|Poly-Ser.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						AACTCTTCCAGCTCCTCTCCT	0.448			NA											73	118					1.92865e-43	3.38186e-43	0.00361	1	0
ODZ4	26011	broad.mit.edu	37	11	78369392	78369392	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:78369392C>A	uc001ozl.3	-	34	8484	c.8021G>T	c.(8020-8022)TGC>TTC	p.C2674F	ODZ4_uc001ozk.3_Missense_Mutation_p.C899F|ODZ4_uc009yvb.1_Intron	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2674	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						TGTGTTCAAGCACAGTGCCCC	0.602			NA											12	13					3.07112e-06	3.69318e-06	0.000978	1	0
PCF11	51585	broad.mit.edu	37	11	82877481	82877481	+	Silent	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:82877481G>T	uc001ozx.3	+	5	1887	c.1542G>T	c.(1540-1542)TCG>TCT	p.S514S	PCF11_uc010rsu.1_Silent_p.S514S	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	514					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						CTCCAACATCGACACCTAAAG	0.448			NA											38	117					8.16277e-20	1.32932e-19	0.006999	1	0
TYR	7299	broad.mit.edu	37	11	88911891	88911891	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:88911891C>A	uc001pcs.2	+	1	852	c.770C>A	c.(769-771)CCC>CAC	p.P257H		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	257	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	GGTCAGCACCCCACAAATCCT	0.453			NA							Oculocutaneous_Albinism				32	90					9.65021e-13	1.40468e-12	0.002096	1	0
FAT3	120114	broad.mit.edu	37	11	92086401	92086401	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:92086401A>T	uc001pdj.3	+	1	1140	c.1123A>T	c.(1123-1125)AGA>TGA	p.R375*		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	375	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGTCCCCATTAGATTTGAAAA	0.418			NA								TCGA Ovarian(4;0.039)			12	37					0	0	0.001855	0	0
FAT3	120114	broad.mit.edu	37	11	92523266	92523266	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:92523266A>T	uc001pdj.3	+	7	4510	c.4493A>T	c.(4492-4494)CAT>CTT	p.H1498L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1498	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TACACTGTTCATAGCAGCATC	0.512			NA								TCGA Ovarian(4;0.039)			41	171					0	0	0.00874	0	0
FAT3	120114	broad.mit.edu	37	11	92531031	92531031	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:92531031C>A	uc001pdj.3	+	9	4869	c.4852C>A	c.(4852-4854)CCG>ACG	p.P1618T		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1618	Cadherin 15.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TAAGATCGAACCGGTCCTAGG	0.418			NA								TCGA Ovarian(4;0.039)			21	109					2.21704e-12	3.19626e-12	0.00278	1	0
FAT3	120114	broad.mit.edu	37	11	92616355	92616355	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:92616355T>A	uc001pdj.3	+	23	12750	c.12733T>A	c.(12733-12735)TCC>ACC	p.S4245T	FAT3_uc001pdi.3_Missense_Mutation_p.S685T	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4245	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCAGAGTGACTCCAGGAGCAA	0.677			NA								TCGA Ovarian(4;0.039)			42	179					0	0	0.002852	0	0
CNTN5	53942	broad.mit.edu	37	11	100061934	100061934	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:100061934G>T	uc001pga.2	+	14	1996	c.1657G>T	c.(1657-1659)GGG>TGG	p.G553W	CNTN5_uc009ywv.1_Missense_Mutation_p.G553W|CNTN5_uc001pfz.2_Missense_Mutation_p.G553W|CNTN5_uc001pgb.2_Missense_Mutation_p.G479W|CNTN5_uc010ruk.1_Translation_Start_Site	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	553	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CGTTTGCCGAGGGGAAAACGT	0.393			NA											14	49					2.61681e-11	3.72279e-11	0.00245	1	0
GUCY1A2	2977	broad.mit.edu	37	11	106681097	106681097	+	Silent	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:106681097T>C	uc001pjg.1	-	5	1704	c.1314A>G	c.(1312-1314)CTA>CTG	p.L438L	GUCY1A2_uc010rvo.1_Silent_p.L459L|GUCY1A2_uc009yxn.1_Silent_p.L438L	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	438					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		CTGAGAGATGTAGCCCTCGGC	0.448			NA											21	88					0	0	0.002299	0	0
EXPH5	23086	broad.mit.edu	37	11	108382102	108382102	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:108382102C>G	uc001pkk.2	-	6	4243	c.4132G>C	c.(4132-4134)GAT>CAT	p.D1378H	EXPH5_uc010rvy.1_Missense_Mutation_p.D1190H|EXPH5_uc010rvz.1_Missense_Mutation_p.D1222H|EXPH5_uc010rwa.1_Missense_Mutation_p.D1302H	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1378					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TTTTCTGAATCACCTAGAGGT	0.373			NA											28	67					0	0	0.00632	0	0
DDX10	1662	broad.mit.edu	37	11	108810978	108810978	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:108810978C>T	uc001pkm.2	+	18	2521	c.2456C>T	c.(2455-2457)ACC>ATC	p.T819I		NM_004398	NP_004389	Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	819							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		ACCAGTGATACCAAGAAGAAG	0.393			NA	T	NUP98	AML*								5	68					0	0	0.000602	0	0
NCAM1	4684	broad.mit.edu	37	11	113078056	113078056	+	Silent	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:113078056G>C	uc009yyq.1	+	6	1042	c.348G>C	c.(346-348)GTG>GTC	p.V116V	NCAM1_uc001pno.2_Silent_p.V116V	NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	234	Ig-like C2-type 3.|Extracellular (Potential).				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		TCACCCTGGTGTGCGATGCCG	0.537			NA											26	85					0	0	0.00632	0	0
HTR3B	9177	broad.mit.edu	37	11	113815415	113815415	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:113815415G>C	uc001pok.2	+	8	1095	c.1028G>C	c.(1027-1029)CGA>CCA	p.R343P	HTR3B_uc001pol.2_Missense_Mutation_p.R332P	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	343	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		TTGTGCCTTCGAGGGGACACC	0.552			NA											35	92					0	0	0.003755	0	0
SIK3	23387	broad.mit.edu	37	11	116729004	116729004	+	Silent	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:116729004T>C	uc001ppy.2	-	20	2895	c.2859A>G	c.(2857-2859)CAA>CAG	p.Q953Q	SIK3_uc001ppz.2_Silent_p.Q792Q|SIK3_uc001pqa.2_Silent_p.Q893Q|SIK3_uc001ppw.2_Silent_p.Q310Q|SIK3_uc001ppx.2_Silent_p.Q331Q|SIK3_uc001pqb.2_Silent_p.Q256Q	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	953	Gln-rich.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						ATTCTtgctgttgctgctgtt	0.458			NA											5	45					0	0	0.000602	0	0
PCSK7	9159	broad.mit.edu	37	11	117100470	117100470	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:117100470G>T	uc001pqr.2	-	3	292	c.91C>A	c.(91-93)CTG>ATG	p.L31M	RNF214_uc001pqt.2_5'Flank|RNF214_uc001pqu.2_5'Flank|RNF214_uc010rxf.1_5'Flank	NM_004716	NP_004707	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	31					peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		CAGGGAACCAGTAAGAAGAGC	0.652			NA	T	IGH@	MLCLS								14	37					7.93312e-07	9.75787e-07	0.00245	1	0
ATP5L	10632	broad.mit.edu	37	11	118279722	118279722	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:118279722T>A	uc001psx.2	+	3	498	c.221T>A	c.(220-222)GTG>GAG	p.V74E		NM_006476	NP_006467	O75964	ATP5L_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	74					ATP catabolic process|respiratory electron transport chain	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity|protein binding				0	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)		CAGGAAGCTGTGCTGAATGGT	0.333			NA											5	69					0	0	0.000602	0	0
C2CD2L	9854	broad.mit.edu	37	11	118983228	118983228	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:118983228C>T	uc001pvo.2	+	9	1480	c.1121C>T	c.(1120-1122)TCC>TTC	p.S374F	C2CD2L_uc001pvn.2_Missense_Mutation_p.S374F	NM_014807	NP_055622	O14523	C2C2L_HUMAN	transmembrane protein 24	374						integral to membrane					0						CCTGTGGGCTCCCCCTCCAGA	0.652			NA											10	169					0	0	0.008291	0	0
HINFP	25988	broad.mit.edu	37	11	119002578	119002578	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:119002578G>T	uc001pvp.2	+	6	751	c.562G>T	c.(562-564)GAG>TAG	p.E188*	HINFP_uc001pvq.2_Nonsense_Mutation_p.E188*|HINFP_uc001pvr.2_5'UTR	NM_015517	NP_056332	Q9BQA5	HINFP_HUMAN	MBD2 (methyl-CpG-binding protein)-interacting	188	C2H2-type 3.				DNA damage checkpoint|DNA repair|establishment of protein localization|in utero embryonic development|myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	enzyme binding|histone binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						TAAACTTCGAGAGCACCTCCG	0.547			NA											23	57					2.21704e-12	3.19626e-12	0.00278	1	0
PVRL1	5818	broad.mit.edu	37	11	119549368	119549368	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:119549368T>A	uc001pwv.2	-	2	359	c.187A>T	c.(187-189)ACC>TCC	p.T63S	PVRL1_uc001pwu.1_Missense_Mutation_p.T63S|PVRL1_uc001pww.2_Missense_Mutation_p.T63S	NM_002855	NP_002846	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 1	63	Extracellular (Potential).|Ig-like V-type.				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		GTGACCTGGGTGATCTTCACG	0.597			NA											9	38					0	0	0.004482	0	0
TECTA	7007	broad.mit.edu	37	11	120996267	120996267	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:120996267G>A	uc010rzo.1	+	7	1460	c.1460G>A	c.(1459-1461)GGA>GAA	p.G487E		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	487	VWFD 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CTGGATCTGGGAGAGAGCTGG	0.577			NA											7	179					0	0	0.00308	0	0
CRTAM	56253	broad.mit.edu	37	11	122738173	122738173	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:122738173A>G	uc001pyj.2	+	8	874	c.874A>G	c.(874-876)ACG>GCG	p.T292A	CRTAM_uc001pyk.2_Missense_Mutation_p.T93A	NM_019604	NP_062550	O95727	CRTAM_HUMAN	class-I MHC-restricted T cell associated	292	Helical; (Potential).				cell recognition|detection of tumor cell|positive regulation of cytokine secretion|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	integral to membrane|plasma membrane	receptor binding			ovary(1)	1		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		CCTGCTGCTCACGCTGGTGTC	0.413			NA											6	43					0	0	0.001168	0	0
GRAMD1B	57476	broad.mit.edu	37	11	123480527	123480527	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:123480527A>C	uc001pyx.2	+	12	1582	c.1253A>C	c.(1252-1254)AAG>ACG	p.K418T	GRAMD1B_uc001pyw.2_Missense_Mutation_p.K425T|GRAMD1B_uc010rzw.1_Missense_Mutation_p.K378T|GRAMD1B_uc010rzx.1_Missense_Mutation_p.K378T|GRAMD1B_uc009zbe.1_Missense_Mutation_p.K414T|GRAMD1B_uc001pyy.2_Missense_Mutation_p.K109T	NM_020716	NP_065767	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	418						integral to membrane				ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		CCATGGAAAAAGGAGGAGAAT	0.527			NA											3	17					0	0	0.004672	0	0
OR8D4	338662	broad.mit.edu	37	11	123777145	123777145	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:123777145G>T	uc010saa.1	+	1	7	c.7G>T	c.(7-9)GTA>TTA	p.V3L		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		AAGAATGGGTGTAAAAAACCA	0.378			NA											27	80					2.79863e-10	3.86478e-10	0.004656	1	0
OR4D5	219875	broad.mit.edu	37	11	123810867	123810867	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:123810867C>A	uc001pzk.1	+	1	544	c.544C>A	c.(544-546)CCT>ACT	p.P182T		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TTGTGATGTGCCTCAGCTGAT	0.478			NA											38	165					5.43694e-19	8.7014e-19	0.005524	1	0
ARHGAP32	9743	broad.mit.edu	37	11	128839516	128839516	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:128839516C>T	uc009zcp.2	-	22	5550	c.5550G>A	c.(5548-5550)CCG>CCA	p.P1850P	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Silent_p.P809P|ARHGAP32_uc001qez.2_Silent_p.P1501P	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	1850	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						ATGGCTTCTCCGGCTGCGTGC	0.607			NA											10	74					0	0	0.006214	0	0
IGSF9B	22997	broad.mit.edu	37	11	133792462	133792462	+	Splice_Site	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr11:133792462A>T	uc001qgx.3	-	16	2512	c.2281_splice	c.e16+1	p.D761_splice		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B							integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		ACAGACACCCACCTTTTTTGC	0.557			NA											4	28					0	0	0.000602	0	0
ANO2	57101	broad.mit.edu	37	12	5853336	5853336	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:5853336G>T	uc001qnm.2	-	12	1398	c.1326C>A	c.(1324-1326)TTC>TTA	p.F442L		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	447	Helical; (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						ACAGAGCCATGAAGATAGAGA	0.542			NA											15	41					3.41278e-10	4.68714e-10	0.00499	1	0
LEPREL2	10536	broad.mit.edu	37	12	6942764	6942764	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:6942764G>C	uc001qra.1	+	9	1255	c.1221G>C	c.(1219-1221)TGG>TGC	p.W407C	LEPREL2_uc001qqz.1_Missense_Mutation_p.W214C|LEPREL2_uc001qrb.1_Missense_Mutation_p.W214C	NM_014262	NP_055077	Q8IVL6	P3H3_HUMAN	leprecan-like 2 precursor	407					negative regulation of cell proliferation	endoplasmic reticulum	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity				0					L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	AGGACCCCTGGACCCCTGCAG	0.557			NA											4	49					0	0	0.009096	0	0
TAS2R14	50840	broad.mit.edu	37	12	11091224	11091224	+	Silent	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:11091224G>A	uc010shi.1	-	1	583	c.583C>T	c.(583-585)CTG>TTG	p.L195L	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_023922	NP_076411	Q9NYV8	T2R14_HUMAN	taste receptor, type 2, member 14	195	Helical; Name=5; (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste		bitter taste receptor activity				0						AACATTGCCAGGGACAAAGTA	0.423			NA											24	43					0	0	0.00333	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20893164	20893164	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:20893164G>T	uc001rej.3	+	13	1950	c.1595G>T	c.(1594-1596)GGA>GTA	p.G532V	SLCO1C1_uc010sii.1_Missense_Mutation_p.G532V|SLCO1C1_uc010sij.1_Missense_Mutation_p.G483V|SLCO1C1_uc009zip.2_Missense_Mutation_p.G366V|SLCO1C1_uc001rei.2_Missense_Mutation_p.G532V|SLCO1C1_uc010sik.1_Missense_Mutation_p.G414V	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	532	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					TCTAAATCCGGAAATTCCTCA	0.353			NA											32	86					1.99505e-19	3.22113e-19	0.002445	1	0
SLCO1C1	53919	broad.mit.edu	37	12	20893173	20893173	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:20893173C>T	uc001rej.3	+	13	1959	c.1604C>T	c.(1603-1605)TCA>TTA	p.S535L	SLCO1C1_uc010sii.1_Missense_Mutation_p.S535L|SLCO1C1_uc010sij.1_Missense_Mutation_p.S486L|SLCO1C1_uc009zip.2_Missense_Mutation_p.S369L|SLCO1C1_uc001rei.2_Missense_Mutation_p.S535L|SLCO1C1_uc010sik.1_Missense_Mutation_p.S417L	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	535	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					GGAAATTCCTCAGGCATAGTG	0.373			NA											34	89					0	0	0.003271	0	0
C12orf39	80763	broad.mit.edu	37	12	21680124	21680124	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:21680124C>T	uc001rfa.1	+	3	294	c.143C>T	c.(142-144)GCA>GTA	p.A48V	C12orf39_uc009ziv.1_5'Flank|C12orf39_uc009ziw.1_5'Flank	NM_030572	NP_085049	Q9BT56	SPXN_HUMAN	spexin precursor	48						extracellular region|nucleus|transport vesicle					0						CTGAAAGGGGCACGTAAGTTC	0.458			NA											37	60					0	0	0.004878	0	0
Unknown	0	broad.mit.edu	37	12	31297895	31297895	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:31297895C>G	uc010sjy.1	-	13	1735	c.1735G>C	c.(1735-1737)GCT>CCT	p.A579P						RecName: Full=Ovostatin homolog 1; Flags: Precursor;												NA						CCATCCACAGCCCCGAGGGCA	0.468			NA											34	57					0	0	0.002836	0	0
FAM113B	91523	broad.mit.edu	37	12	47629773	47629773	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:47629773C>A	uc001rpn.2	+	4	1658	c.927C>A	c.(925-927)CGC>CGA	p.R309R	FAM113B_uc010slj.1_Silent_p.R189R|FAM113B_uc001rpq.2_Silent_p.R309R	NM_138371	NP_612380	Q96HM7	F113B_HUMAN	hypothetical protein LOC91523	309	Pro-rich.						hydrolase activity			skin(3)|ovary(2)	5	Renal(347;0.138)|Lung SC(27;0.192)					caccccagcgcttgccgctgc	0.249			NA											20	40					4.35082e-09	5.81652e-09	0.010504	1	0
PRKAG1	5571	broad.mit.edu	37	12	49398789	49398789	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:49398789T>A	uc001rsy.2	-	7	437	c.368A>T	c.(367-369)CAG>CTG	p.Q123L	uc001rsw.2_Intron|PRKAG1_uc010smd.1_Missense_Mutation_p.Q91L|PRKAG1_uc001rsx.2_Missense_Mutation_p.Q39L|PRKAG1_uc001rsz.2_Missense_Mutation_p.Q132L|PRKAG1_uc009zlb.2_Intron|PRKAG1_uc010sme.1_Missense_Mutation_p.Q123L	NM_002733	NP_002724	P54619	AAKG1_HUMAN	AMP-activated protein kinase, noncatalytic	123					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|positive regulation of protein kinase activity|regulation of fatty acid oxidation|regulation of glycolysis|spermatogenesis	cytosol	cAMP-dependent protein kinase activity|cAMP-dependent protein kinase regulator activity|protein kinase binding			kidney(1)	1						AAAGGAGTCCTGGAGATACAC	0.463			NA											44	73					0	0	0.002522	0	0
TBC1D15	64786	broad.mit.edu	37	12	72290500	72290500	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:72290500T>C	uc001swu.2	+	10	1154	c.1145T>C	c.(1144-1146)CTG>CCG	p.L382P	TBC1D15_uc009zrv.2_Missense_Mutation_p.L244P|TBC1D15_uc010stt.1_Missense_Mutation_p.L351P|TBC1D15_uc001swv.2_Missense_Mutation_p.L365P|TBC1D15_uc001sww.2_Missense_Mutation_p.L114P	NM_022771	NP_073608	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15 isoform 1	360	Rab-GAP TBC.						protein binding|Rab GTPase activator activity				0						AAATTTCTTCTGGGTTATTTT	0.338			NA											20	45					0	0	0.002299	0	0
NAV3	89795	broad.mit.edu	37	12	78516179	78516179	+	Silent	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:78516179G>T	uc001syp.2	+	16	4382	c.4209G>T	c.(4207-4209)ACG>ACT	p.T1403T	NAV3_uc001syo.2_Silent_p.T1403T|NAV3_uc010sub.1_Silent_p.T903T|NAV3_uc009zsf.2_Intron	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1403	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TCATGAGAACGGGTAGTGTGA	0.547			NA								HNSCC(70;0.22)			26	57					3.6726e-16	5.65131e-16	0.003954	1	0
MYF5	4617	broad.mit.edu	37	12	81112714	81112714	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:81112714G>T	uc001szg.2	+	3	787	c.652G>T	c.(652-654)GAG>TAG	p.E218*		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	218					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						CACCTCCTCAGAGCAACCTGG	0.488			NA											29	66					9.80776e-20	1.59033e-19	0.00632	1	0
MYF5	4617	broad.mit.edu	37	12	81112716	81112716	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:81112716G>T	uc001szg.2	+	3	789	c.654G>T	c.(652-654)GAG>GAT	p.E218D		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	218					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						CCTCCTCAGAGCAACCTGGGT	0.493			NA											29	65					9.80776e-20	1.59033e-19	0.00632	1	0
SLC6A15	55117	broad.mit.edu	37	12	85277694	85277694	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:85277694C>G	uc001szv.2	-	5	1193	c.700G>C	c.(700-702)GCT>CCT	p.A234P	SLC6A15_uc010sul.1_Missense_Mutation_p.A127P|SLC6A15_uc001szy.2_Missense_Mutation_p.A234P	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	234	Helical; Name=4; (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						ACCCAGGCAGCCAACAAGCAG	0.443			NA											8	22					0	0	0.00308	0	0
VEZT	55591	broad.mit.edu	37	12	95650954	95650954	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:95650954C>T	uc001tdz.2	+	3	302	c.197C>T	c.(196-198)ACC>ATC	p.T66I	VEZT_uc009zsy.1_Intron|VEZT_uc001tdr.2_Intron|VEZT_uc001tds.2_Missense_Mutation_p.T18I|VEZT_uc001tdt.2_Missense_Mutation_p.T18I|VEZT_uc009zsz.1_Missense_Mutation_p.T66I|VEZT_uc001tdv.2_Missense_Mutation_p.T35I|VEZT_uc001tdw.1_Missense_Mutation_p.T18I|VEZT_uc009zta.1_Missense_Mutation_p.T18I	NM_017599	NP_060069	Q9HBM0	VEZA_HUMAN	vezatin, adherens junctions transmembrane	66						acrosomal vesicle|adherens junction|integral to membrane|nucleus				ovary(1)	1						GTGGCTGAAACCATCAAAAGT	0.348			NA											5	11					0	0	0.001984	0	0
ANKS1B	56899	broad.mit.edu	37	12	99640545	99640545	+	Silent	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:99640545G>A	uc001tge.1	-	13	2271	c.1854C>T	c.(1852-1854)TCC>TCT	p.S618S	ANKS1B_uc001tgf.1_Silent_p.S198S|ANKS1B_uc001tgk.2_5'UTR|ANKS1B_uc009ztt.1_Silent_p.S584S	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	618						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GATTTTCAGGGGACTCACAGG	0.468			NA											17	144					0	0	0.008871	0	0
FAM71C	196472	broad.mit.edu	37	12	100042361	100042361	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:100042361C>G	uc001tgn.2	+	1	831	c.409C>G	c.(409-411)CAG>GAG	p.Q137E	ANKS1B_uc001tge.1_Intron|ANKS1B_uc001tgf.1_Intron|ANKS1B_uc009ztt.1_Intron	NM_153364	NP_699195	Q8NEG0	FA71C_HUMAN	hypothetical protein LOC196472	137											0				OV - Ovarian serous cystadenocarcinoma(2;0.00733)|Epithelial(2;0.0385)|all cancers(2;0.19)		CGTAAAAAAACAGCTCCACCT	0.468			NA											25	68					0	0	0.004656	0	0
STAB2	55576	broad.mit.edu	37	12	104071263	104071263	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:104071263C>A	uc001tjw.2	+	25	2865	c.2679C>A	c.(2677-2679)CAC>CAA	p.H893Q		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	893	Extracellular (Potential).|EGF-like 8.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CGGGCACCCACACCTGCGTGT	0.542			NA											45	70					9.84934e-19	1.57006e-18	0.002522	1	0
NOS1	4842	broad.mit.edu	37	12	117768676	117768676	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr12:117768676C>T	uc001twm.1	-	2	885	c.199G>A	c.(199-201)GTC>ATC	p.V67I		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	67	Interaction with NOSIP (By similarity).|PDZ.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CGGCCGTTGACCGCAAGAATG	0.632	Esophageal Squamous(162;1748 2599 51982 52956)		NA											25	36					0	0	0.00278	0	0
STARD13	90627	broad.mit.edu	37	13	33692207	33692207	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr13:33692207T>C	uc001uuw.2	-	8	2402	c.2276A>G	c.(2275-2277)TAT>TGT	p.Y759C	STARD13_uc001uuu.2_Missense_Mutation_p.Y751C|STARD13_uc001uuv.2_Missense_Mutation_p.Y641C|STARD13_uc001uux.2_Missense_Mutation_p.Y724C|STARD13_uc010tec.1_RNA	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	759	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		CTTACACTGATAGATATGGAG	0.403			NA											27	47					0	0	0.007291	0	0
DOCK9	23348	broad.mit.edu	37	13	99534187	99534187	+	Silent	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr13:99534187G>A	uc001vnt.2	-	24	2692	c.2637C>T	c.(2635-2637)CTC>CTT	p.L879L	DOCK9_uc001vnw.2_Silent_p.L878L|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Silent_p.L879L|DOCK9_uc010tis.1_Silent_p.L878L|DOCK9_uc010tit.1_Silent_p.L879L|DOCK9_uc010afu.1_Silent_p.L725L	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	879	DHR-1.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TGGCTCTGGTGAGGACTCGGA	0.532			NA											4	7					0	0	0.009096	0	0
DOCK9	23348	broad.mit.edu	37	13	99537313	99537313	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr13:99537313C>T	uc001vnt.2	-	21	2352	c.2297G>A	c.(2296-2298)GGA>GAA	p.G766E	DOCK9_uc001vnw.2_Missense_Mutation_p.G765E|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.G766E|DOCK9_uc010tis.1_Missense_Mutation_p.G765E|DOCK9_uc010tit.1_Missense_Mutation_p.G766E|DOCK9_uc010afu.1_Missense_Mutation_p.G612E	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	766	DHR-1.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CACCACCCTTCCGTCTTTCAG	0.507			NA											11	15					0	0	0.000978	0	0
TM9SF2	9375	broad.mit.edu	37	13	100193814	100193814	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr13:100193814A>G	uc001voj.1	+	9	1043	c.910A>G	c.(910-912)ATT>GTT	p.I304V	TM9SF2_uc010afz.1_Missense_Mutation_p.I139V	NM_004800	NP_004791	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2 precursor	304	Helical; (Potential).				transport	endosome membrane|integral to plasma membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					TTTCTACAGCATTATGAATTC	0.333			NA											33	64					0	0	0.009535	0	0
NALCN	259232	broad.mit.edu	37	13	101755671	101755671	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr13:101755671C>A	uc001vox.1	-	26	3098	c.2909G>T	c.(2908-2910)TGT>TTT	p.C970F		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	970	Helical; Name=S3 of repeat III; (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AGGCATCCAACAAAGAAATAT	0.453			NA											18	47					7.07596e-05	8.14546e-05	0.006122	1	0
DAOA	267012	broad.mit.edu	37	13	106118662	106118662	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr13:106118662G>A	uc001vqb.2	+	1	299	c.25G>A	c.(25-27)GAT>AAT	p.D9N	DAOA_uc010tjf.1_5'UTR|DAOA_uc001vpz.2_RNA|DAOA_uc010agd.2_RNA|DAOA_uc010tjg.1_5'UTR|DAOA_uc001vqc.2_RNA|DAOA_uc001vqe.2_5'Flank	NM_172370	NP_758958	P59103	DAOA_HUMAN	D-amino acid oxidase activator isoform 1	9						Golgi apparatus					0	Lung NSC(43;0.01)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					gatgggtgctgattctctcca	0			NA											16	52					0	0	0.007413	0	0
DAOA	267012	broad.mit.edu	37	13	106142289	106142289	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr13:106142289G>T	uc001vqb.2	+	4	595	c.321G>T	c.(319-321)ATG>ATT	p.M107I	DAOA_uc010tjf.1_Missense_Mutation_p.M36I|DAOA_uc001vpz.2_RNA|DAOA_uc010agd.2_RNA|DAOA_uc010tjg.1_Missense_Mutation_p.M79I|DAOA_uc001vqc.2_RNA|DAOA_uc001vqe.2_RNA	NM_172370	NP_758958	P59103	DAOA_HUMAN	D-amino acid oxidase activator isoform 1	107						Golgi apparatus					0	Lung NSC(43;0.01)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					aagtcttcatggcaagaaact	0			NA											11	34					1.58986e-06	1.92726e-06	0.008291	1	0
FLJ10357	55701	broad.mit.edu	37	14	21542500	21542500	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:21542500A>T	uc001vzp.2	+	3	640	c.611A>T	c.(610-612)GAA>GTA	p.E204V	FLJ10357_uc001vzn.1_Missense_Mutation_p.E204V|FLJ10357_uc001vzo.1_Intron|FLJ10357_uc010aij.2_RNA|FLJ10357_uc010tln.1_5'UTR	NM_018071	NP_060541	Q8TER5	ARH40_HUMAN	hypothetical protein LOC55701	204					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;5.79e-11)|Epithelial(56;8.35e-09)|all cancers(55;4.23e-08)	GBM - Glioblastoma multiforme(265;0.0197)		CTGCCCCCAGAACTGCCCTCT	0.617			NA											11	36					0	0	0.001368	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21769217	21769217	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:21769217G>T	uc001wag.2	+	3	311	c.311G>T	c.(310-312)GGG>GTG	p.G104V		NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	104					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		GCAAGGCGCGGGCAGAAGGCG	0.726			NA											6	37					5.9392e-07	7.40191e-07	0.001168	1	0
OR4E2	26686	broad.mit.edu	37	14	22133475	22133475	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:22133475A>T	uc010tmd.1	+	1	179	c.179A>T	c.(178-180)TAT>TTT	p.Y60F		NM_001001912	NP_001001912	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E,	60	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		ACCCCCATGTATTTCTTCCTG	0.418			NA											75	235					0	0	0.00361	0	0
PSMB11	122706	broad.mit.edu	37	14	23511514	23511515	+	Missense_Mutation	DNP	GG	GG	CT			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:23511514_23511515GG>CT	uc010ake.1	+	1	139_140	c.80_81GG>CT	c.(79-81)TGG>TCT	p.W27S		NM_001099780	NP_001093250	A5LHX3	PSB11_HUMAN	proteasome beta 11 subunit precursor	27					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00643)		GCTGGCGGCTGGGCTGTGCCCC	0.639			NA											6	113					0	0	0.004672	0	0
MYH6	4624	broad.mit.edu	37	14	23866757	23866757	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:23866757G>T	uc001wjv.2	-	16	2024	c.1957C>A	c.(1957-1959)CAC>AAC	p.H653N		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	653	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CTTACCCGGTGGAGAGCCGAC	0.517			NA											10	69					3.86212e-05	4.48006e-05	0.008291	1	0
MYH6	4624	broad.mit.edu	37	14	23876424	23876424	+	Silent	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:23876424A>G	uc001wjv.2	-	3	76	c.9T>C	c.(7-9)GAT>GAC	p.D3D	MYH6_uc010akp.1_Silent_p.D3D	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	3	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CCATCTGGGCATCGGTCATCT	0.617			NA											17	115					0	0	0.00499	0	0
LRFN5	145581	broad.mit.edu	37	14	42356834	42356834	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:42356834G>T	uc001wvm.2	+	3	2204	c.1006G>T	c.(1006-1008)GTG>TTG	p.V336L	LRFN5_uc010ana.2_Missense_Mutation_p.V336L	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	336	Extracellular (Potential).|Ig-like.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		AAGATCTCTGGTGTATGATAA	0.453			NA								HNSCC(30;0.082)			26	96					2.50493e-22	4.16017e-22	0.004656	1	0
FAM179B	23116	broad.mit.edu	37	14	45475342	45475342	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:45475342A>G	uc001wvv.2	+	5	2985	c.2776A>G	c.(2776-2778)AAA>GAA	p.K926E	FAM179B_uc001wvw.2_Missense_Mutation_p.K926E|FAM179B_uc010anc.2_RNA|FAM179B_uc001wvu.2_Missense_Mutation_p.K926E	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	926							binding			skin(2)|upper_aerodigestive_tract(1)	3						TTTGCCTGATAAAGCTGATTT	0.423			NA											14	126					0	0	0.00245	0	0
FAM179B	23116	broad.mit.edu	37	14	45535891	45535891	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:45535891G>A	uc001wvv.2	+	16	4720	c.4511G>A	c.(4510-4512)CGT>CAT	p.R1504H	FAM179B_uc001wvw.2_Missense_Mutation_p.R1557H|FAM179B_uc010anc.2_RNA	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	1504							binding			skin(2)|upper_aerodigestive_tract(1)	3						AAAGACTTTCGTGATCGTATT	0.358			NA											6	82					0	0	0.001984	0	0
FANCM	57697	broad.mit.edu	37	14	45645568	45645568	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:45645568G>T	uc001wwd.3	+	14	3710	c.3611G>T	c.(3610-3612)CGT>CTT	p.R1204L	FANCM_uc010anf.2_Missense_Mutation_p.R1178L|FANCM_uc001wwe.3_Missense_Mutation_p.R740L|FANCM_uc010ang.2_Missense_Mutation_p.R418L	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1204					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						TTTAAATCTCGTGATCAGAGA	0.353			NA						Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				13	61					0.00010058	0.000114731	0.001368	1	0
DACT1	51339	broad.mit.edu	37	14	59112433	59112433	+	Silent	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:59112433T>A	uc001xdw.2	+	4	1256	c.1092T>A	c.(1090-1092)GCT>GCA	p.A364A	DACT1_uc010trv.1_Silent_p.A83A|DACT1_uc001xdx.2_Silent_p.A327A|DACT1_uc010trw.1_Silent_p.A83A	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	364					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						GCGTGAACGCTGACCCCACGA	0.517			NA											19	43					0	0	0.007413	0	0
ZBTB25	7597	broad.mit.edu	37	14	64957115	64957115	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:64957115G>C	uc001xhf.2	-	2	320	c.137C>G	c.(136-138)TCT>TGT	p.S46C	ZBTB25_uc001xhc.2_Missense_Mutation_p.S46C|ZBTB25_uc001xhg.2_Missense_Mutation_p.S46C	NM_006977	NP_008908	P24278	ZBT25_HUMAN	zinc finger protein 46	46	BTB.					cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2				all cancers(60;0.00865)|OV - Ovarian serous cystadenocarcinoma(108;0.0102)|BRCA - Breast invasive adenocarcinoma(234;0.0469)		GAAATAGTTAGAAAAAGCAGC	0.328			NA											13	72					0	0	0.001855	0	0
SLC39A9	55334	broad.mit.edu	37	14	69925101	69925101	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:69925101G>C	uc001xle.2	+	7	1395	c.715G>C	c.(715-717)GAG>CAG	p.E239Q	SLC39A9_uc010aqx.2_Missense_Mutation_p.E216Q|SLC39A9_uc001xlf.3_Intron|SLC39A9_uc001xlg.3_RNA	NM_018375	NP_060845	Q9NUM3	S39A9_HUMAN	solute carrier family 39 (zinc transporter),	239					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity				0				all cancers(60;0.00299)|BRCA - Breast invasive adenocarcinoma(234;0.0145)|OV - Ovarian serous cystadenocarcinoma(108;0.0373)		AGCCCTTTCAGAGGTGAACGC	0.468			NA											7	177					0	0	0.001984	0	0
RGS6	9628	broad.mit.edu	37	14	72976888	72976888	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:72976888A>C	uc001xna.3	+	14	1515	c.992A>C	c.(991-993)AAA>ACA	p.K331T	RGS6_uc010ttn.1_Missense_Mutation_p.K331T|RGS6_uc001xmx.3_Missense_Mutation_p.K331T|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.K331T|RGS6_uc010ttp.1_Missense_Mutation_p.K262T|RGS6_uc001xmz.1_Missense_Mutation_p.K192T	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	331					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		CAGCGAGTAAAAAGATGGGGC	0.468	Ovarian(143;1926 2468 21071 48641)		NA											18	162					0	0	0.00499	0	0
C14orf43	91748	broad.mit.edu	37	14	74206049	74206049	+	Silent	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:74206049G>A	uc001xot.2	-	2	1446	c.663C>T	c.(661-663)TTC>TTT	p.F221F	C14orf43_uc001xou.2_Silent_p.F221F|C14orf43_uc010tud.1_Silent_p.F221F|C14orf43_uc010arw.2_RNA	NM_194278	NP_919254	Q6PJG2	CN043_HUMAN	hypothetical protein LOC91748	221	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00358)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)|OV - Ovarian serous cystadenocarcinoma(108;0.115)		CCTGGTGGCCGAATGCCAGCT	0.567			NA											7	71					0	0	0.00308	0	0
C14orf4	64207	broad.mit.edu	37	14	77492113	77492113	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:77492113G>C	uc001xsy.2	-	1	2922	c.2023C>G	c.(2023-2025)CGT>GGT	p.R675G		NM_024496	NP_078772	Q9H1B7	I2BPL_HUMAN	chromosome 14 open reading frame 4	675						nucleus					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.00347)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)		TCCCCGTTACGTGATGCCAAG	0.677			NA											9	41					0	0	0.004482	0	0
ISM2	145501	broad.mit.edu	37	14	77942393	77942393	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:77942393G>T	uc001xtz.2	-	7	1335	c.1261C>A	c.(1261-1263)CAG>AAG	p.Q421K	ISM2_uc001xua.2_3'UTR|ISM2_uc001xty.2_Missense_Mutation_p.Q333K|ISM2_uc010tvl.1_Missense_Mutation_p.Q340K	NM_199296	NP_954993	Q6H9L7	ISM2_HUMAN	isthmin 2 homolog isoform 1	421	AMOP.					extracellular region				skin(1)	1						CGCAGCATCTGGCTCAGATAC	0.602			NA											17	45					6.94344e-10	9.43307e-10	0.006122	1	0
KCNK13	56659	broad.mit.edu	37	14	90651010	90651010	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:90651010G>T	uc001xye.1	+	2	1332	c.890G>T	c.(889-891)GGG>GTG	p.G297V		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	297	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				ATGGACAGCGGGTGCTGCCCG	0.532			NA											17	91					6.49762e-13	9.47622e-13	0.006122	1	0
SERPINA1	5265	broad.mit.edu	37	14	94847330	94847330	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:94847330C>T	uc001ycx.3	-	3	1056	c.795G>A	c.(793-795)CTG>CTA	p.L265L	SERPINA1_uc001ycw.3_RNA|SERPINA1_uc010auw.2_Silent_p.L265L|SERPINA1_uc010aux.2_Silent_p.L265L|SERPINA1_uc001ycy.3_Silent_p.L265L|SERPINA1_uc010auy.2_Silent_p.L265L|SERPINA1_uc001ycz.3_Silent_p.L265L|SERPINA1_uc010auz.2_Silent_p.L265L|SERPINA1_uc010ava.2_Silent_p.L265L|SERPINA1_uc001ydb.3_Silent_p.L265L|SERPINA1_uc010avb.2_Silent_p.L265L|SERPINA1_uc001ydc.3_Silent_p.L265L|SERPINA1_uc001yda.1_Silent_p.L265L	NM_000295	NP_000286	P01009	A1AT_HUMAN	serine proteinase inhibitor, clade A, member 1	265					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			skin(1)	1		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	GGTATTTCATCAGCAGCACCC	0.512			NA							Alpha-1-Antitrypsin_Deficiency				9	73					0	0	0.004482	0	0
TCL1B	9623	broad.mit.edu	37	14	96152829	96152829	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:96152829C>A	uc001yez.2	+	1	67	c.25C>A	c.(25-27)CTA>ATA	p.L9I	TCL1B_uc001yew.2_Intron|TCL1B_uc001yex.2_Intron|TCL1B_uc010avj.2_Intron|TCL1B_uc001yfa.2_Missense_Mutation_p.L9I	NM_004918	NP_004909	O95988	TCL1B_HUMAN	T-cell leukemia/lymphoma 1B	9										ovary(1)	1		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		TTCTGTGCGTCTAGGGGTGCC	0.602			NA											17	77					3.45872e-05	4.04321e-05	0.004007	1	0
PAPOLA	10914	broad.mit.edu	37	14	97022202	97022202	+	Silent	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr14:97022202A>T	uc001yfq.2	+	18	1893	c.1683A>T	c.(1681-1683)CCA>CCT	p.P561P	PAPOLA_uc001yfr.2_Silent_p.P560P|PAPOLA_uc010twv.1_Silent_p.P561P|PAPOLA_uc010avp.2_Silent_p.P311P	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	561	Ser/Thr-rich.				mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		GTCCTGCTCCAGCTGTAACAG	0.289	NSCLC(19;254 734 11908 35501 39234)		NA											8	98					0	0	0.006214	0	0
TRPM1	4308	broad.mit.edu	37	15	31359339	31359339	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr15:31359339C>A	uc001zfm.2	-	5	607	c.479G>T	c.(478-480)AGA>ATA	p.R160I	TRPM1_uc010azy.2_Missense_Mutation_p.R73I|TRPM1_uc001zfl.2_RNA|uc010ubm.1_5'Flank|MIR211_hsa-mir-211|MI0000287_5'Flank|uc010ubn.1_5'Flank	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	160	Extracellular (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		AACCCGGCCTCTGGACTTGGA	0.488			NA											14	89					2.62699e-14	3.93006e-14	0.003163	1	0
RYR3	6263	broad.mit.edu	37	15	33603268	33603269	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr15:33603268_33603269GG>TT	uc001zhi.2	+	1	92_93	c.22_23GG>TT	c.(22-24)GGC>TTC	p.G8F	RYR3_uc010bar.2_Missense_Mutation_p.G8F	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	8	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGGAGAAGGAGGCGAGGACGAG	0.743			NA											7	17					0	0	0.004672	0	0
RYR3	6263	broad.mit.edu	37	15	34130564	34130564	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr15:34130564G>A	uc001zhi.2	+	89	12453	c.12383G>A	c.(12382-12384)GGT>GAT	p.G4128D	RYR3_uc010bar.2_Missense_Mutation_p.G4123D	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4128					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GAAATTGCGGGTGAAGAGGAA	0.493			NA											40	82					0	0	0.00874	0	0
SPRED1	161742	broad.mit.edu	37	15	38632064	38632064	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr15:38632064A>G	uc001zka.3	+	5	885	c.550A>G	c.(550-552)AGA>GGA	p.R184G		NM_152594	NP_689807	Q7Z699	SPRE1_HUMAN	sprouty-related protein 1 with EVH-1 domain	184					inactivation of MAPK activity|multicellular organismal development	caveola|nucleus	stem cell factor receptor binding			ovary(2)|lung(2)|skin(1)	5		all_cancers(109;4.88e-13)|all_epithelial(112;1.83e-11)|Lung NSC(122;2.21e-09)|all_lung(180;4.64e-08)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(113;2.41e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		TCTGAATGCCAGAAGAGTCTA	0.373	Melanoma(196;2146 2959 7698 16532)		NA							Legius_syndrome				14	34					0	0	0.00245	0	0
INO80	54617	broad.mit.edu	37	15	41377671	41377671	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr15:41377671C>T	uc001zni.2	-	7	982	c.769G>A	c.(769-771)GAT>AAT	p.D257N	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	257	Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80D.|Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						GGAGGTGCATCGTGAGAAAAC	0.458			NA											11	93					0	0	0.008291	0	0
TMEM62	80021	broad.mit.edu	37	15	43446871	43446871	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr15:43446871G>A	uc001zqr.2	+	9	1303	c.1024G>A	c.(1024-1026)GTC>ATC	p.V342I	TMEM62_uc010bda.2_Missense_Mutation_p.V212I	NM_024956	NP_079232	Q0P6H9	TMM62_HUMAN	transmembrane protein 62	342						integral to membrane				ovary(1)|breast(1)	2		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)		TCATTTTAGAGTCTTGGCCTT	0.378			NA											6	34					0	0	0.001168	0	0
KIAA1370	56204	broad.mit.edu	37	15	52905960	52905960	+	Silent	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr15:52905960T>A	uc002acg.3	-	3	264	c.111A>T	c.(109-111)GTA>GTT	p.V37V	KIAA1370_uc002ach.3_RNA|KIAA1370_uc010bfg.1_Intron|KIAA1370_uc010ugf.1_Silent_p.V44V	NM_019600	NP_062546	Q32MH5	K1370_HUMAN	hypothetical protein LOC56204	37											0				all cancers(107;0.0803)		TTCGACCTTTTACAGAACATT	0.428			NA											4	31					0	0	0.009096	0	0
WDR72	256764	broad.mit.edu	37	15	53809911	53809911	+	Silent	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr15:53809911G>A	uc002acj.2	-	20	3336	c.3294C>T	c.(3292-3294)CCC>CCT	p.P1098P	WDR72_uc010bfh.1_RNA	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	1098										lung(1)|skin(1)	2				all cancers(107;0.0511)		ACACCTTGCAGGGGCAGACCT	0.363			NA											20	88					0	0	0.001882	0	0
C15orf59	388135	broad.mit.edu	37	15	74043389	74043389	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr15:74043389C>T	uc002avy.2	-	1	428	c.83G>A	c.(82-84)CGC>CAC	p.R28H		NM_001039614	NP_001034703	Q2T9L4	CO059_HUMAN	hypothetical protein LOC388135	28										pancreas(1)	1						CATCTTCATGCGCTGTCGAAT	0.642			NA											14	90					0	0	0.001855	0	0
TM6SF1	53346	broad.mit.edu	37	15	83790720	83790720	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr15:83790720T>A	uc002bjp.2	+	5	555	c.446T>A	c.(445-447)ATG>AAG	p.M149K	TM6SF1_uc010bmq.2_Missense_Mutation_p.M149K|TM6SF1_uc002bjq.2_Missense_Mutation_p.M149K|TM6SF1_uc010bmr.2_Intron|TM6SF1_uc002bjr.2_Missense_Mutation_p.M1K	NM_023003	NP_075379	Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1 isoform 1	149	Helical; (Potential).					integral to membrane				ovary(1)	1						TCTATTATTATGAGTGTTGTT	0.318			NA											23	82					0	0	0.00333	0	0
PIGQ	9091	broad.mit.edu	37	16	624190	624190	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:624190C>G	uc002cho.2	+	2	218	c.116C>G	c.(115-117)CCC>CGC	p.P39R	PIGQ_uc010bqw.2_Missense_Mutation_p.P39R|PIGQ_uc002chm.2_Missense_Mutation_p.P39R|PIGQ_uc002chn.2_Missense_Mutation_p.P39R|PIGQ_uc010uui.1_Missense_Mutation_p.P53R	NM_148920	NP_683721	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	39					C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)	1		Hepatocellular(780;0.00335)				CTGCACTTTCCCTTCATCCCC	0.701			NA											7	21					0	0	0.001984	0	0
PKD1	5310	broad.mit.edu	37	16	2160655	2160655	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:2160655C>A	uc002cos.1	-	15	4722	c.4513G>T	c.(4513-4515)GGT>TGT	p.G1505C	PKD1_uc002cot.1_Missense_Mutation_p.G1505C	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	1505	Extracellular (Potential).|PKD 10.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						AGCCACCCACCGTCCCCCAGA	0.662			NA											27	43					4.31634e-10	5.89586e-10	0.002445	1	0
IL32	9235	broad.mit.edu	37	16	3119310	3119310	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:3119310A>T	uc002cto.2	+	6	870	c.659A>T	c.(658-660)GAG>GTG	p.E220V	IL32_uc002ctk.2_Missense_Mutation_p.E117V|IL32_uc010uwp.1_Missense_Mutation_p.E154V|IL32_uc010btb.2_Missense_Mutation_p.E164V|IL32_uc002ctl.2_Missense_Mutation_p.E174V|IL32_uc002ctm.2_Missense_Mutation_p.E174V|IL32_uc002ctn.2_Missense_Mutation_p.E174V|IL32_uc002cts.3_Missense_Mutation_p.E174V|IL32_uc002ctp.2_Missense_Mutation_p.E154V|IL32_uc002ctq.2_Missense_Mutation_p.E220V|IL32_uc002ctr.2_Missense_Mutation_p.E154V|IL32_uc002ctt.2_Missense_Mutation_p.E174V|IL32_uc010uwr.1_Missense_Mutation_p.E134V|IL32_uc002ctu.2_Missense_Mutation_p.E165V	NM_004221	NP_004212	P24001	IL32_HUMAN	interleukin 32 isoform B	220					cell adhesion|defense response|immune response	extracellular space	cytokine activity			pancreas(1)	1						GGGGACAAGGAGGAGCTGACA	0.582			NA											11	169					0	0	0.001368	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3139379	3139379	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:3139379C>A	uc002ctv.1	-	5	1979	c.1891G>T	c.(1891-1893)GGC>TGC	p.G631C	ZSCAN10_uc002cty.1_Missense_Mutation_p.G292C|ZSCAN10_uc002ctw.1_Missense_Mutation_p.G549C|ZSCAN10_uc002ctx.1_Missense_Mutation_p.G559C	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	631					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						GGCCGCTCGCCCGTGTGGCTG	0.706			NA											8	38					5.18039e-06	6.20988e-06	0.00308	1	0
ZSCAN10	84891	broad.mit.edu	37	16	3140317	3140317	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:3140317C>A	uc002ctv.1	-	5	1041	c.953G>T	c.(952-954)GGG>GTG	p.G318V	ZSCAN10_uc002cty.1_5'UTR|ZSCAN10_uc002ctw.1_Missense_Mutation_p.G236V|ZSCAN10_uc002ctx.1_Missense_Mutation_p.G246V	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	318					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						GAAGGAGCGCCCAGCCGGGTG	0.672			NA											7	61					8.12818e-05	9.28583e-05	0.001984	1	0
ZNF263	10127	broad.mit.edu	37	16	3339416	3339416	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:3339416G>A	uc002cuq.2	+	6	1242	c.910G>A	c.(910-912)GAA>AAA	p.E304K	ZNF263_uc010uww.1_5'UTR|ZNF263_uc002cur.2_5'UTR	NM_005741	NP_005732	O14978	ZN263_HUMAN	zinc finger protein 263	304					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(3)|ovary(1)	4						TGAGAACCTGGAAGGTGTTCC	0.532			NA											30	150					0	0	0.003271	0	0
USP7	7874	broad.mit.edu	37	16	8999176	8999176	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:8999176C>G	uc002czl.2	-	14	1640	c.1441G>C	c.(1441-1443)GAT>CAT	p.D481H	USP7_uc010uyk.1_Missense_Mutation_p.D382H|USP7_uc002czj.2_RNA|USP7_uc010uyj.1_Missense_Mutation_p.D382H|USP7_uc002czk.2_Missense_Mutation_p.D465H|USP7_uc010uyl.1_RNA	NM_003470	NP_003461	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7	481					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3						ACGTCGTCATCAAATTTACAC	0.458			NA									OREG0023595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	97					0	0	0.008871	0	0
PDILT	204474	broad.mit.edu	37	16	20370884	20370884	+	Missense_Mutation	SNP	C	C	G	rs148051428		TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:20370884C>G	uc002dhc.1	-	12	1735	c.1512G>C	c.(1510-1512)TTG>TTC	p.L504F		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	504					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						GCTCAACAGACAACAGCTATG	0.343			NA											13	84					0	0	0.001855	0	0
HS3ST2	9956	broad.mit.edu	37	16	22926316	22926316	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:22926316C>A	uc002dli.2	+	2	609	c.537C>A	c.(535-537)CCC>CCA	p.P179P	HS3ST2_uc002dlj.2_RNA	NM_006043	NP_006034	Q9Y278	HS3S2_HUMAN	heparan sulfate D-glucosaminyl	179	Lumenal (Potential).|Substrate binding (By similarity).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(48;0.0299)		AGAAGACGCCCAGCTACTTTG	0.567			NA											35	55					1.08052e-11	1.54301e-11	0.004289	1	0
PRKCB	5579	broad.mit.edu	37	16	24185863	24185863	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:24185863C>G	uc002dmd.2	+	12	1553	c.1356C>G	c.(1354-1356)ATC>ATG	p.I452M	PRKCB_uc002dme.2_Missense_Mutation_p.I452M	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	452	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	AAATTGCCATCGGTCTGTTCT	0.423			NA											3	48					0	0	0.004672	0	0
CACNG3	10368	broad.mit.edu	37	16	24372682	24372682	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:24372682A>T	uc002dmf.2	+	4	1646	c.446A>T	c.(445-447)AAC>ATC	p.N149I		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	149	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		GGGTTAAGCAACATCATTGGC	0.413			NA											32	124					0	0	0.002836	0	0
ITGAL	3683	broad.mit.edu	37	16	30505533	30505533	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:30505533G>T	uc002dyi.3	+	12	1390	c.1214G>T	c.(1213-1215)GGT>GTT	p.G405V	ITGAL_uc002dyj.3_Missense_Mutation_p.G322V|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	405	FG-GAP 4.|Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	CTTTCCTCAGGTTACACCGTG	0.602	NSCLC(110;1462 1641 3311 33990 49495)		NA											32	85					4.65686e-17	7.29995e-17	0.003755	1	0
ZNF629	23361	broad.mit.edu	37	16	30793054	30793054	+	Silent	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:30793054T>A	uc002dzs.1	-	3	2803	c.2595A>T	c.(2593-2595)CCA>CCT	p.P865P		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	865					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			GGGAGACACCTGGGTGGCAGC	0.562			NA											10	37					0	0	0.006214	0	0
ITGAM	3684	broad.mit.edu	37	16	31283197	31283197	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:31283197C>G	uc002ebq.2	+	7	686	c.588C>G	c.(586-588)TTC>TTG	p.F196L	ITGAM_uc002ebr.2_Missense_Mutation_p.F196L	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	196	VWFA.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						CTGAAGAATTCCGGATTCACT	0.557			NA											16	45					0	0	0.004007	0	0
ITGAD	3681	broad.mit.edu	37	16	31408773	31408773	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:31408773C>G	uc002ebv.1	+	3	280	c.231C>G	c.(229-231)ATC>ATG	p.I77M	ITGAD_uc010vfl.1_Missense_Mutation_p.I77M|ITGAD_uc010cap.1_Missense_Mutation_p.I77M|ITGAD_uc002ebw.1_5'Flank	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	77	FG-GAP 2.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						GCCAGCCCATCCCGCTGCACA	0.647			NA											2	11					0	0	0.004672	0	0
ABCC11	85320	broad.mit.edu	37	16	48250146	48250146	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:48250146T>C	uc002eff.1	-	6	1180	c.830A>G	c.(829-831)TAT>TGT	p.Y277C	ABCC11_uc002efg.1_Missense_Mutation_p.Y277C|ABCC11_uc002efh.1_Missense_Mutation_p.Y277C|ABCC11_uc010vgk.1_5'Flank|ABCC11_uc010vgl.1_Missense_Mutation_p.Y277C	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	277	ABC transmembrane type-1 1.|Helical; (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				TAGGGGTCCATAGCACACCCC	0.478			NA							Cerumen_Type				22	134					0	0	0.004656	0	0
ZNF423	23090	broad.mit.edu	37	16	49671294	49671294	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:49671294T>C	uc002efs.2	-	5	2067	c.1769A>G	c.(1768-1770)AAC>AGC	p.N590S	ZNF423_uc010vgn.1_Missense_Mutation_p.N473S	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	590					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				CAGTGGAATGTTCTTGTGGTT	0.572			NA											21	78					0	0	0.010504	0	0
CES3	23491	broad.mit.edu	37	16	66997479	66997479	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:66997479C>G	uc002eqt.2	+	3	446	c.373C>G	c.(373-375)CTG>GTG	p.L125V	CES3_uc010cdz.2_Missense_Mutation_p.L125V|CES3_uc010cea.2_RNA	NM_024922	NP_079198	Q6UWW8	EST3_HUMAN	carboxylesterase 3 precursor	125						endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			ovary(3)|central_nervous_system(2)	5		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0488)|Epithelial(162;0.127)		AGAGGACTGCCTGGTCCTCAA	0.592			NA											5	46					0	0	0.000602	0	0
VAC14	55697	broad.mit.edu	37	16	70778352	70778352	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:70778352C>A	uc002ezm.2	-	13	1760	c.1502G>T	c.(1501-1503)GGC>GTC	p.G501V	VAC14_uc010cfw.2_Missense_Mutation_p.G267V|VAC14_uc002ezn.2_Missense_Mutation_p.G66V|VAC14_uc010cfx.1_5'UTR	NM_018052	NP_060522	Q08AM6	VAC14_HUMAN	Vac14 homolog	501					interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			pancreas(1)|skin(1)	2		Ovarian(137;0.0699)				GCCGGCTCTGCCAGGGGTGGG	0.647			NA											7	47					1.08611e-07	1.3951e-07	0.000978	1	0
TAF1C	9013	broad.mit.edu	37	16	84212974	84212974	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:84212974C>A	uc002fhn.2	-	14	2411	c.2183G>T	c.(2182-2184)CGA>CTA	p.R728L	TAF1C_uc002fhm.2_Missense_Mutation_p.R634L|TAF1C_uc010vnx.1_Missense_Mutation_p.R702L|TAF1C_uc010vny.1_Missense_Mutation_p.R319L|TAF1C_uc010vnz.1_Missense_Mutation_p.R396L|TAF1C_uc002fho.2_Missense_Mutation_p.R251L|TAF1C_uc010voa.1_Missense_Mutation_p.R396L|TAF1C_uc002fhp.1_Intron	NM_005679	NP_005670	Q15572	TAF1C_HUMAN	TBP-associated factor 1C isoform 1	728					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			ovary(1)	1						GGCAGCCCCTCGGCCTGCCCA	0.706			NA											15	17					1.52009e-12	2.20838e-12	0.003163	1	0
TP53	7157	broad.mit.edu	37	17	7579485	7579485	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:7579485C>A	uc002gim.2	-	4	396	c.202G>T	c.(202-204)GAG>TAG	p.E68*	TP53_uc002gig.1_Nonsense_Mutation_p.E68*|TP53_uc002gih.2_Nonsense_Mutation_p.E68*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Nonsense_Mutation_p.E68*|TP53_uc010cni.1_Nonsense_Mutation_p.E68*|TP53_uc002gij.2_Nonsense_Mutation_p.E68*|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Nonsense_Mutation_p.E29*|TP53_uc010cnk.1_Nonsense_Mutation_p.E83*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	68	Interaction with WWOX.|Interaction with HRMT1L2.		E -> Q (in a sporadic cancer; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.E68*(4)|p.G59fs*23(3)|p.E68G(2)|p.E68fs*55(2)|p.E68fs*76(1)|p.D48fs*55(1)|p.R65_P71delRMPEAAP(1)|p.E68fs*81(1)|p.P13fs*18(1)|p.R65fs*38(1)|p.D57_A76del20(1)|p.E68Q(1)|p.S33fs*23(1)|p.M66fs*80(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAGCAGCCTCTGGCATTCTG	0.607	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			58	99					1.64573e-32	2.8526e-32	0.00361	1	0
MYH4	4622	broad.mit.edu	37	17	10354208	10354208	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:10354208C>A	uc002gmn.2	-	29	3981	c.3870G>T	c.(3868-3870)GAG>GAT	p.E1290D	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1290	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GTCGTGAAAACTCACCTGTGG	0.353			NA											38	73					1.59361e-14	2.39359e-14	0.006999	1	0
MYH1	4619	broad.mit.edu	37	17	10409131	10409131	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:10409131C>A	uc002gmo.2	-	19	2266	c.2172G>T	c.(2170-2172)CAG>CAT	p.Q724H	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	724	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TGTCTGACCTCTGTTTGAAGT	0.383			NA											15	36					2.4624e-09	3.30953e-09	0.008871	1	0
DNAH9	1770	broad.mit.edu	37	17	11772454	11772454	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:11772454C>T	uc002gne.2	+	51	10005	c.9937C>T	c.(9937-9939)CTT>TTT	p.L3313F	DNAH9_uc010coo.2_Missense_Mutation_p.L2607F	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3313	Stalk (By similarity).|Potential.				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TAAACAGCACCTTAATGAAAA	0.388			NA											23	72					0	0	0.003954	0	0
SDF2	6388	broad.mit.edu	37	17	26982498	26982498	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:26982498C>A	uc002hbw.2	-	2	194	c.155G>T	c.(154-156)AGT>ATT	p.S52I	SDF2_uc002hbx.2_RNA	NM_006923	NP_008854	Q99470	SDF2_HUMAN	stromal cell-derived factor 2 precursor	52	MIR 1.				protein glycosylation	extracellular space|membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity				0	Lung NSC(42;0.00431)					CTGCTGCCCACTACCTGCAGT	0.517			NA											33	115					3.11337e-16	4.80058e-16	0.002836	1	0
CORO6	84940	broad.mit.edu	37	17	27944550	27944550	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:27944550T>A	uc002hel.2	-	5	723	c.721A>T	c.(721-723)ATG>TTG	p.M241L	CORO6_uc002hem.2_Intron|CORO6_uc002hen.2_5'UTR	NM_032854	NP_116243	Q6QEF8	CORO6_HUMAN	coronin 6	241	WD 4.				actin cytoskeleton organization	actin cytoskeleton	actin filament binding				0						CGCTGGCTCATGCGGGTGAAG	0.697			NA											10	25					0	0	0.008291	0	0
SLC6A4	6532	broad.mit.edu	37	17	28544217	28544217	+	Silent	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:28544217G>A	uc002hey.3	-	6	1348	c.804C>T	c.(802-804)TTC>TTT	p.F268F		NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	268	Helical; Name=4; (Potential).				response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	TCCAGATGCTGAAGTAGATAA	0.597			NA											29	102					0	0	0.00632	0	0
RAB11FIP4	84440	broad.mit.edu	37	17	29854858	29854858	+	Splice_Site	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:29854858A>G	uc002hgn.1	+	11	1504	c.1275_splice	c.e11-2	p.R425_splice	RAB11FIP4_uc002hgo.2_Splice_Site_p.R323_splice	NM_032932	NP_116321	Q86YS3	RFIP4_HUMAN	RAB11 family interacting protein 4 (class II)						cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			skin(1)	1		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)				TCCTTTCGCCAGGGTGCAGCA	0.483			NA											4	11					0	0	0.009096	0	0
NLE1	54475	broad.mit.edu	37	17	33469093	33469093	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:33469093C>A	uc002hiy.1	-	2	95	c.67G>T	c.(67-69)GAT>TAT	p.D23Y	NLE1_uc010ctn.1_5'UTR|NLE1_uc002hiz.1_5'UTR	NM_018096	NP_060566	Q9NVX2	NLE1_HUMAN	Notchless gene homolog isoform a	23						nucleolus				breast(3)|ovary(1)	4		Ovarian(249;0.17)				CCGCCCTCATCCTGGAACTGC	0.687			NA											7	20					0.00448238	0.00474679	0.004482	1	0
TAF15	8148	broad.mit.edu	37	17	34171540	34171540	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:34171540G>A	uc002hkd.2	+	15	1323	c.1237G>A	c.(1237-1239)GGA>AGA	p.G413R	TAF15_uc002hkc.2_Missense_Mutation_p.G410R	NM_139215	NP_631961	Q92804	RBP56_HUMAN	TBP-associated factor 15 isoform 1	413	Arg/Gly-rich.|1.|21 X approximate tandem repeats of D-R- [S,G](0,3)-G-G-Y-G-G.				positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		TAF15/NR4A3(33)	bone(33)|lung(1)|skin(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		GGGCAGAggtggagaccgagg	0.269			NA	T	TEC|CHN1|ZNF384	extraskeletal myxoid chondrosarcomas|ALL								39	115					0	0	0.004878	0	0
C17orf78	284099	broad.mit.edu	37	17	35745728	35745728	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:35745728C>A	uc002hns.2	+	5	682	c.632C>A	c.(631-633)CCT>CAT	p.P211H	ACACA_uc002hnn.2_Intron|ACACA_uc002hno.2_Intron|ACACA_uc002hnq.2_Intron|C17orf78_uc010cva.1_Intron	NM_173625	NP_775896	Q8N4C9	CQ078_HUMAN	hypothetical protein LOC284099	211						integral to membrane					0		Breast(25;0.00295)|Ovarian(249;0.15)				GTCCCATGTCCTGTAAGTTTG	0.308			NA											8	19					0.000157383	0.000177645	0.00308	1	0
KRT38	8687	broad.mit.edu	37	17	39597091	39597091	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:39597091A>G	uc002hwq.1	-	1	506	c.83T>C	c.(82-84)ATC>ACC	p.I28T		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	28	Head.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				CCCAATGTCGATGGGAGAGAC	0.602			NA											13	65					0	0	0.001855	0	0
NKIRAS2	28511	broad.mit.edu	37	17	40174504	40174504	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:40174504A>G	uc002hyq.2	+	3	247	c.182A>G	c.(181-183)GAC>GGC	p.D61G	NKIRAS2_uc010wgd.1_Intron|NKIRAS2_uc002hyr.2_Missense_Mutation_p.D61G|NKIRAS2_uc002hys.2_Missense_Mutation_p.D61G|NKIRAS2_uc010wge.1_Intron|NKIRAS2_uc002hyt.2_Missense_Mutation_p.D61G	NM_001001349	NP_001001349	Q9NYR9	KBRS2_HUMAN	NFKB inhibitor interacting Ras-like 2 isoform a	61	GTP (By similarity).|Small GTPase-like.				I-kappaB kinase/NF-kappaB cascade|small GTPase mediated signal transduction	cytoplasm	GTP binding|GTPase activity			ovary(1)	1		all_cancers(22;1.1e-05)|Breast(137;0.000143)|all_epithelial(22;0.000319)				CGTTTCTATGACACCCGGGGG	0.562			NA											5	29					0	0	0.000602	0	0
NAGLU	4669	broad.mit.edu	37	17	40690377	40690377	+	Silent	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:40690377G>C	uc002hzv.2	+	3	892	c.552G>C	c.(550-552)CTG>CTC	p.L184L		NM_000263	NP_000254	P54802	ANAG_HUMAN	alpha-N-acetylglucosaminidase precursor	184						lysosome	alpha-N-acetylglucosaminidase activity				0		all_cancers(22;1.58e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)	N-Acetyl-D-glucosamine(DB00141)	CCTTGGGCCTGACCCAGGCAG	0.448			NA											16	196					0	0	0.004007	0	0
MEOX1	4222	broad.mit.edu	37	17	41738734	41738734	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:41738734C>A	uc002idz.2	-	1	198	c.169G>T	c.(169-171)GCA>TCA	p.A57S	MEOX1_uc002iea.2_Missense_Mutation_p.A57S|MEOX1_uc002ieb.2_5'UTR	NM_004527	NP_004518	P50221	MEOX1_HUMAN	mesenchyme homeobox 1 isoform 1	57						nucleus	sequence-specific DNA binding				0		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0753)		GGGTACGCTGCCGTCGCTGTC	0.642			NA											23	45					6.21321e-17	9.6993e-17	0.00278	1	0
CD300LG	146894	broad.mit.edu	37	17	41926217	41926217	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:41926217G>A	uc002iem.2	+	2	376	c.335G>A	c.(334-336)CGG>CAG	p.R112Q	CD300LG_uc002iek.1_Missense_Mutation_p.R112Q|CD300LG_uc002iel.1_Missense_Mutation_p.R112Q|CD300LG_uc010czk.2_Missense_Mutation_p.R112Q|CD300LG_uc010wil.1_Missense_Mutation_p.R112Q|CD300LG_uc010czl.2_Missense_Mutation_p.R112Q	NM_145273	NP_660316	Q6UXG3	CLM9_HUMAN	CD300 molecule-like family member g precursor	112	Extracellular (Potential).|Ig-like V-type.					apical plasma membrane|basolateral plasma membrane|integral to membrane|multivesicular body membrane	receptor activity				0		Breast(137;0.0199)		BRCA - Breast invasive adenocarcinoma(366;0.115)		GTCGAAAAACGGGGCCCCGAT	0.582			NA											17	72					0	0	0.006122	0	0
C17orf104	284071	broad.mit.edu	37	17	42745405	42745405	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:42745405T>A	uc010czv.2	+	5	2126	c.2126T>A	c.(2125-2127)TTA>TAA	p.L709*	C17orf104_uc002igy.1_Nonsense_Mutation_p.L543*|C17orf104_uc002igz.3_Nonsense_Mutation_p.L543*|C17orf104_uc010wja.1_RNA|C17orf104_uc002iha.2_Nonsense_Mutation_p.L543*	NM_001145080	NP_001138552	A2RUB1	CQ104_HUMAN	hypothetical protein LOC284071	709										central_nervous_system(1)	1						TCCTATGACTTACTTTCTTAT	0.368			NA											8	16					0	0	0.006214	0	0
EFTUD2	9343	broad.mit.edu	37	17	42930740	42930740	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:42930740C>G	uc002ihn.2	-	25	2746	c.2485G>C	c.(2485-2487)GAG>CAG	p.E829Q	EFTUD2_uc010wje.1_Missense_Mutation_p.E794Q|EFTUD2_uc010wjf.1_Missense_Mutation_p.E819Q	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	829						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)				TAGTAAGGCTCCATCAGACGA	0.587	Ovarian(10;65 485 10258 29980 30707)		NA											30	96					0	0	0.00632	0	0
PLCD3	113026	broad.mit.edu	37	17	43192477	43192477	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:43192477G>C	uc002iib.2	-	11	1810	c.1696C>G	c.(1696-1698)CTC>GTC	p.L566V		NM_133373	NP_588614	Q8N3E9	PLCD3_HUMAN	phospholipase C delta 3	566	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(2)|lung(1)	3					Phosphatidylserine(DB00144)	TCCCGAATGAGTTTCTTGGCT	0.647			NA											2	11					0	0	0.004672	0	0
TBX21	30009	broad.mit.edu	37	17	45822141	45822141	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:45822141C>A	uc002ilv.1	+	6	1228	c.1017C>A	c.(1015-1017)ATC>ATA	p.I339I		NM_013351	NP_037483	Q9UL17	TBX21_HUMAN	T-box 21	339					lymphocyte migration|multicellular organismal development|positive regulation of transcription, DNA-dependent|response to virus	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0						ACACCAGCATCCCCTCCCCGC	0.527			NA											37	151					1.69901e-12	2.45884e-12	0.005524	1	0
MYCBPAP	84073	broad.mit.edu	37	17	48594812	48594812	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:48594812C>A	uc010wmr.1	+	3	654	c.492C>A	c.(490-492)TCC>TCA	p.S164S	MYCBPAP_uc002iqx.2_Silent_p.S164S|MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	127					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			TGGACTACTCCGGTACACCCA	0.517			NA											44	110					5.78141e-17	9.04395e-17	0.003214	1	0
WFIKKN2	124857	broad.mit.edu	37	17	48916967	48916967	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:48916967C>A	uc002isv.3	+	2	1012	c.318C>A	c.(316-318)CCC>CCA	p.P106P	WFIKKN2_uc010dbu.2_Silent_p.P13P	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	106						extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			TGGGCATGCCCAAGGAGGCCA	0.587			NA											9	25					0.000274275	0.000303231	0.004482	1	0
MPO	4353	broad.mit.edu	37	17	56355306	56355306	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:56355306C>A	uc002ivu.1	-	7	1263	c.1086G>T	c.(1084-1086)CTG>CTT	p.L362L		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	362					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	TGACGGCCAGCAGCCCCAGCT	0.642			NA											8	58					5.18039e-06	6.20988e-06	0.00308	1	0
ACE	1636	broad.mit.edu	37	17	61557855	61557855	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:61557855C>A	uc002jau.1	+	5	835	c.813C>A	c.(811-813)ATC>ATA	p.I271I	ACE_uc010wpi.1_Silent_p.I271I|ACE_uc010ddu.1_Silent_p.I88I	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	271	Extracellular (Potential).|Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	ACAGATACATCAACCTCAGGG	0.612			NA											22	96					0.000375601	0.000414646	0.00278	1	0
SCN4A	6329	broad.mit.edu	37	17	62041161	62041161	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:62041161C>A	uc002jds.1	-	10	1554	c.1477G>T	c.(1477-1479)GGT>TGT	p.G493C		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	493					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	GCCTCCCCACCTTCCAGAGCT	0.617			NA											8	8					0.000274275	0.000303231	0.004482	1	0
HELZ	9931	broad.mit.edu	37	17	65103393	65103393	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:65103393C>A	uc010wqk.1	-	31	5323	c.5136G>T	c.(5134-5136)CAG>CAT	p.Q1712H	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.Q1711H	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					CAAAAGGGTTCTGCGGTGGCC	0.473			NA											35	218					3.90053e-15	5.92943e-15	0.002445	1	0
SLC16A6	9120	broad.mit.edu	37	17	66267221	66267221	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:66267221G>T	uc002jgz.1	-	5	1268	c.1080C>A	c.(1078-1080)TAC>TAA	p.Y360*	ARSG_uc002jhc.2_Intron|SLC16A6_uc002jha.1_Nonsense_Mutation_p.Y360*	NM_004694	NP_004685	O15403	MOT7_HUMAN	solute carrier family 16, member 6	360	Helical; (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity				0	all_cancers(12;1.24e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)		Pyruvic acid(DB00119)	TGAGCTCAATGTAAATCTTAC	0.433			NA											38	104					6.05902e-23	1.0085e-22	0.003755	1	0
CDC42EP4	23580	broad.mit.edu	37	17	71282496	71282496	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:71282496C>T	uc002jjn.2	-	2	291	c.144G>A	c.(142-144)GGG>GGA	p.G48G	CDC42EP4_uc002jjo.2_Silent_p.G48G|CDC42EP4_uc002jjp.1_Silent_p.G48G	NM_012121	NP_036253	Q9H3Q1	BORG4_HUMAN	Cdc42 effector protein 4	48					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|cytoplasm|endomembrane system|membrane|microtubule cytoskeleton	GTP-Rho binding				0			LUSC - Lung squamous cell carcinoma(166;0.0352)|Lung(188;0.0711)			AGGAGGTGTCCCCAAAGGCGT	0.647			NA											7	58					0	0	0.001984	0	0
DNAI2	64446	broad.mit.edu	37	17	72308204	72308204	+	Silent	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:72308204G>T	uc002jkf.2	+	12	1656	c.1557G>T	c.(1555-1557)CTG>CTT	p.L519L	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA|uc002jkh.1_5'Flank|DNAI2_uc002jki.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	519					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						AGATGCGGCTGAAGGAGAAGG	0.647			NA							Kartagener_syndrome				4	37					2.56e-06	3.08838e-06	0.009096	1	0
KIF19	124602	broad.mit.edu	37	17	72341016	72341016	+	Silent	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:72341016G>T	uc002jkm.3	+	7	837	c.699G>T	c.(697-699)CGG>CGT	p.R233R	KIF19_uc002jkj.2_Silent_p.R233R|KIF19_uc002jkk.2_Silent_p.R191R|KIF19_uc002jkl.2_Silent_p.R191R	NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	233	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						AGCGCAGCCGGGTCAAGAACA	0.692			NA											12	34					2.27111e-07	2.87801e-07	0.001368	1	0
EVPL	2125	broad.mit.edu	37	17	74003663	74003663	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:74003663C>T	uc002jqi.2	-	22	5851	c.5623G>A	c.(5623-5625)GAG>AAG	p.E1875K	EVPL_uc010wss.1_Missense_Mutation_p.E1897K|EVPL_uc010wst.1_Missense_Mutation_p.E1345K	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1875	Globular 2.|Plectin 4.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						GAGTAGCGCTCACGGCTGAGC	0.632			NA											11	131					0	0	0.001368	0	0
BAHCC1	57597	broad.mit.edu	37	17	79408995	79408995	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr17:79408995C>G	uc002kaf.2	+	3	620	c.620C>G	c.(619-621)TCC>TGC	p.S207C	BAHCC1_uc002kae.2_5'Flank	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	207							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			GAGGCAGGCTCCCTGCAGAAG	0.711			NA											5	64					0	0	0.000602	0	0
EMILIN2	84034	broad.mit.edu	37	18	2891640	2891640	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr18:2891640C>A	uc002kln.2	+	4	1674	c.1515C>A	c.(1513-1515)CTC>CTA	p.L505L		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	505					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		GGAGCGTTCTCCTACAGATGA	0.547			NA											10	77					4.68919e-08	6.11704e-08	0.008291	1	0
DLGAP1	9229	broad.mit.edu	37	18	3879681	3879681	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr18:3879681G>T	uc002kmf.2	-	1	455	c.388C>A	c.(388-390)CAC>AAC	p.H130N	DLGAP1_uc010wyz.1_Missense_Mutation_p.H130N|DLGAP1_uc002kmk.2_Missense_Mutation_p.H130N|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	130					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				TCGCTGCGGTGCTCCACGGCC	0.677			NA											31	90					3.99451e-17	6.28781e-17	0.009535	1	0
LAMA1	284217	broad.mit.edu	37	18	6978258	6978258	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr18:6978258G>T	uc002knm.2	-	43	6221	c.6127C>A	c.(6127-6129)CTG>ATG	p.L2043M	LAMA1_uc010wzj.1_Missense_Mutation_p.L1519M	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2043	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACCCTGGACAGGCTGGCAGAT	0.597			NA											14	108					9.31168e-06	1.11092e-05	0.001855	1	0
C18orf1	753	broad.mit.edu	37	18	13645348	13645348	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr18:13645348G>T	uc002ksa.2	+	7	1281	c.613G>T	c.(613-615)GTG>TTG	p.V205L	C18orf1_uc002ksb.2_Missense_Mutation_p.V187L|C18orf1_uc002kse.2_Missense_Mutation_p.V168L|C18orf1_uc002ksf.2_Missense_Mutation_p.V150L|C18orf1_uc002ksg.1_Missense_Mutation_p.V128L|C18orf1_uc002ksh.1_Missense_Mutation_p.V147L|C18orf1_uc002ksi.1_Missense_Mutation_p.V129L	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	205	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		CCGAGAGTCCGTGAGGGCCCC	0.582			NA											11	81					6.40141e-05	7.38022e-05	0.000978	1	0
HRH4	59340	broad.mit.edu	37	18	22056937	22056937	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr18:22056937T>C	uc002kvi.2	+	3	684	c.584T>C	c.(583-585)ATG>ACG	p.M195T	HRH4_uc010xbd.1_3'UTR|HRH4_uc010dlx.2_Missense_Mutation_p.M107T	NM_021624	NP_067637	Q9H3N8	HRH4_HUMAN	histamine H4 receptor isoform 1	195	Cytoplasmic (Potential).					integral to membrane|plasma membrane	histamine receptor activity			ovary(2)	2	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	TATTTCAACATGAATATTTAT	0.438			NA											34	139					0	0	0.003271	0	0
CDH2	1000	broad.mit.edu	37	18	25591899	25591900	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr18:25591899_25591900GG>AT	uc002kwg.2	-	4	915_916	c.456_457CC>AT	c.(454-459)GGCCAC>GGATAC	p.H153Y	CDH2_uc010xbn.1_Missense_Mutation_p.H122Y	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	153					adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						CTTTGTAGGTGGCCACTGTGCT	0.45			NA											11	102					0	0	0.004672	0	0
DSC2	1824	broad.mit.edu	37	18	28648052	28648052	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr18:28648052C>G	uc002kwl.3	-	16	3089	c.2635G>C	c.(2635-2637)GAT>CAT	p.D879H	DSC2_uc002kwk.3_3'UTR	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	879	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TCAAGCCCATCTTCTTCTTGT	0.428			NA											9	65					0	0	0.006214	0	0
DSG3	1830	broad.mit.edu	37	18	29049188	29049188	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr18:29049188C>T	uc002kws.2	+	12	1882	c.1773C>T	c.(1771-1773)AAC>AAT	p.N591N		NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	591	Extracellular (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGTGTGACAACAGGGGCATCT	0.582			NA											19	92					0	0	0.008871	0	0
KLHL14	57565	broad.mit.edu	37	18	30349625	30349625	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr18:30349625C>A	uc002kxm.1	-	2	1318	c.930G>T	c.(928-930)AGG>AGT	p.R310S		NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	310						cytosol|endoplasmic reticulum membrane				ovary(1)	1						CCAGGCTCTGCCTGCAGTGCT	0.403			NA											8	49					0.00448238	0.00474679	0.004482	1	0
KIAA1632	57724	broad.mit.edu	37	18	43531136	43531136	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr18:43531136T>G	uc002lbm.2	-	4	1421	c.1321A>C	c.(1321-1323)ATG>CTG	p.M441L	KIAA1632_uc002lbo.1_Missense_Mutation_p.M441L	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	441					autophagy						0						CTGGTGAACATGAATAAGACA	0.383			NA											4	28					0	0	0.009096	0	0
ALPK2	115701	broad.mit.edu	37	18	56246487	56246487	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr18:56246487C>A	uc002lhj.3	-	4	1735	c.1521G>T	c.(1519-1521)GGG>GGT	p.G507G		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	507							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						ACTGGCTCATCCCTGAGTTTT	0.512			NA									OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	152					5.49717e-05	6.36692e-05	0.00333	1	0
ZNF532	55205	broad.mit.edu	37	18	56606832	56606832	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr18:56606832G>T	uc002lho.2	+	6	3231	c.2684G>T	c.(2683-2685)GGC>GTC	p.G895V	ZNF532_uc002lhp.2_Missense_Mutation_p.G893V|ZNF532_uc010xeg.1_Missense_Mutation_p.G893V|ZNF532_uc002lhr.2_Missense_Mutation_p.G893V|ZNF532_uc002lhs.2_Missense_Mutation_p.G893V	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	895					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						CAGCATCCTGGCATCAAGATA	0.428			NA											19	77					1.96292e-10	2.72568e-10	0.010504	1	0
SERPINB13	5275	broad.mit.edu	37	18	61264493	61264493	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr18:61264493G>T	uc002ljc.2	+	8	1240	c.1072G>T	c.(1072-1074)GCC>TCC	p.A358S	SERPINB13_uc002ljd.2_Missense_Mutation_p.A222S|SERPINB13_uc010xep.1_Missense_Mutation_p.A367S|SERPINB13_uc010xeq.1_Missense_Mutation_p.A179S|SERPINB13_uc010xer.1_Missense_Mutation_p.A179S	NM_012397	NP_036529	Q9UIV8	SPB13_HUMAN	serine (or cysteine) proteinase inhibitor, clade	358					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)	1						TGTCACATCCGCCCCAGGTCA	0.512			NA											10	70					1.58986e-06	1.92726e-06	0.008291	1	0
ZNF236	7776	broad.mit.edu	37	18	74680239	74680239	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr18:74680239G>T	uc002lmi.2	+	31	5680	c.5482G>T	c.(5482-5484)GAG>TAG	p.E1828*	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1828					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CCTCCACCTGGAGGAGGTGGT	0.587			NA											16	78					1.15088e-07	1.47328e-07	0.004007	1	0
SHC2	25759	broad.mit.edu	37	19	419036	419036	+	Silent	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:419036C>G	uc002loq.3	-	12	1641	c.1641G>C	c.(1639-1641)CTG>CTC	p.L547L	SHC2_uc002lop.3_Silent_p.L288L	NM_012435	NP_036567	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing)	547	SH2.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol					0		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCTCTCAAACAGCACGTCCT	0.652			NA											4	3					0	0	0.009096	0	0
MATK	4145	broad.mit.edu	37	19	3779573	3779573	+	Silent	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:3779573G>A	uc002lyt.2	-	10	1285	c.885C>T	c.(883-885)ATC>ATT	p.I295I	MATK_uc002lyv.2_Silent_p.I296I|MATK_uc002lyu.2_Silent_p.I254I|MATK_uc010dtq.2_Silent_p.I295I	NM_139355	NP_647612	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase isoform	295	Protein kinase.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(2)|ovary(1)|lung(1)|large_intestine(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGGTGCAGGATCACGCCCA	0.711			NA											7	11					0	0	0.001984	0	0
TICAM1	148022	broad.mit.edu	37	19	4817343	4817343	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:4817343G>C	uc002mbi.2	-	2	1298	c.1047C>G	c.(1045-1047)TGC>TGG	p.C349W		NM_182919	NP_891549	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	349	Pro-rich.				apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GAGTAGGTGGGCACGGCTTGG	0.478			NA											21	40					0	0	0.002299	0	0
C19orf59	199675	broad.mit.edu	37	19	7742570	7742570	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:7742570C>T	uc002mhh.1	+	2	167	c.142C>T	c.(142-144)CAG>TAG	p.Q48*		NM_174918	NP_777578	Q8IX19	MCEM1_HUMAN	mast cell-expressed membrane protein 1	48	Cytoplasmic (Potential).					integral to membrane				skin(1)	1						CTTCAAAAATCAGGACCATGC	0.577			NA									OREG0025208	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	54					0	0	0.00278	0	0
MUC16	94025	broad.mit.edu	37	19	9046547	9046547	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:9046547G>T	uc002mkp.2	-	5	35288	c.35084C>A	c.(35083-35085)CCA>CAA	p.P11695Q		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11697	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCTGGTCTGTGGAGGATGAGT	0.522			NA											45	75					5.44703e-19	8.7014e-19	0.009718	1	0
MUC16	94025	broad.mit.edu	37	19	9086904	9086904	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:9086904C>T	uc002mkp.2	-	1	5115	c.4911G>A	c.(4909-4911)GGG>GGA	p.G1637G		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1637	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TACTACTGCTCCCTGTTGTTG	0.498			NA											46	88					0	0	0.00361	0	0
CACNA1A	773	broad.mit.edu	37	19	13386728	13386728	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:13386728G>T	uc010dze.2	-	24	4164	c.3928C>A	c.(3928-3930)CGT>AGT	p.R1310S	CACNA1A_uc010xnd.1_Missense_Mutation_p.R15S|CACNA1A_uc002mwx.3_Missense_Mutation_p.R15S|CACNA1A_uc010dzc.2_Missense_Mutation_p.R835S|CACNA1A_uc002mwy.3_Missense_Mutation_p.R1309S|CACNA1A_uc010xne.1_Missense_Mutation_p.R838S	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1310	III.|Helical; Name=S3 of repeat III; (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CAGAGGTCACGGAAGTAGGCA	0.572			NA											12	21					1.05317e-09	1.42566e-09	0.00245	1	0
Unknown	0	broad.mit.edu	37	19	23405513	23405513	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:23405513C>A	uc010xri.1	-	4	1652	c.1534G>T	c.(1534-1536)GGC>TGC	p.G512C						SubName: Full=cDNA FLJ56866, moderately similar to Zinc finger protein 43;												NA						AAAGCTTTGCCACATTCTTTA	0.373			NA											17	28					1.99824e-07	2.54076e-07	0.00499	1	0
RPSAP58	388524	broad.mit.edu	37	19	24010294	24010294	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:24010294C>G	uc002nrn.2	+	4	754	c.331C>G	c.(331-333)CAG>GAG	p.Q111E		NM_002295	NP_002286			ribosomal protein SA												0						CTTCACTAACCAGATCCAGGC	0.567			NA											4	46					0	0	0.009096	0	0
CHST8	64377	broad.mit.edu	37	19	34180198	34180198	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:34180198G>A	uc002nus.3	+	3	536	c.31G>A	c.(31-33)GCC>ACC	p.A11T	CHST8_uc002nut.3_Missense_Mutation_p.A11T|CHST8_uc002nuu.2_Missense_Mutation_p.A11T	NM_001127895	NP_001121367	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0)	11	Helical; Signal-anchor for type II membrane protein; (Potential).				carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			skin(2)|large_intestine(1)|ovary(1)	4	Esophageal squamous(110;0.162)					AATGCGGCTGGCCTGCATGTT	0.652			NA											24	77					0	0	0.00278	0	0
NPHS1	4868	broad.mit.edu	37	19	36321981	36321981	+	Missense_Mutation	SNP	G	G	A	rs143145248		TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:36321981G>A	uc002oby.2	-	27	3455	c.3455C>T	c.(3454-3456)ACG>ATG	p.T1152M	NPHS1_uc010eem.1_RNA	NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	1152	Cytoplasmic (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTCCTCCTGCGTCGGGGGCAG	0.587			NA											47	87					0	0	0.00361	0	0
ZNF585A	199704	broad.mit.edu	37	19	37644259	37644259	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:37644259A>G	uc002ofo.1	-	5	773	c.542T>C	c.(541-543)ATG>ACG	p.M181T	ZNF585A_uc002ofm.1_Missense_Mutation_p.M126T|ZNF585A_uc002ofn.1_Missense_Mutation_p.M126T	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTTCTCTCTCATATGGGTTTT	0.393			NA											20	108					0	0	0.010504	0	0
RYR1	6261	broad.mit.edu	37	19	38948812	38948812	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:38948812G>A	uc002oit.2	+	18	2177	c.2047G>A	c.(2047-2049)GTG>ATG	p.V683M	RYR1_uc002oiu.2_Missense_Mutation_p.V683M	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	683	Cytoplasmic.|B30.2/SPRY 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCACTTGCGGGTGGGCTGGGC	0.647			NA											29	59					0	0	0.008361	0	0
TGFB1	7040	broad.mit.edu	37	19	41847918	41847918	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:41847918G>A	uc002oqh.1	-	5	1597	c.730C>T	c.(730-732)CGA>TGA	p.R244*	CYP2F1_uc010xvw.1_Intron	NM_000660	NP_000651	P01137	TGFB1_HUMAN	transforming growth factor, beta 1 precursor	244	Cell attachment site (Potential).				active induction of host immune response by virus|ATP biosynthetic process|cell cycle arrest|cell growth|cell-cell junction organization|chondrocyte differentiation|connective tissue replacement involved in inflammatory response wound healing|epidermal growth factor receptor signaling pathway|evasion of host defenses by virus|hemopoietic progenitor cell differentiation|induction of apoptosis|lymph node development|mitotic cell cycle G1/S transition checkpoint|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of cell-cell adhesion|negative regulation of DNA replication|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|negative regulation of macrophage cytokine production|negative regulation of mitotic cell cycle|negative regulation of protein phosphorylation|ossification involved in bone remodeling|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of bone mineralization|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of collagen biosynthetic process|positive regulation of epithelial to mesenchymal transition|positive regulation of fibroblast migration|positive regulation of interleukin-17 production|positive regulation of isotype switching to IgA isotypes|positive regulation of MAP kinase activity|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of protein dephosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein secretion|positive regulation of SMAD protein import into nucleus|protein export from nucleus|protein import into nucleus, translocation|receptor catabolic process|regulation of DNA binding|regulation of striated muscle tissue development|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|response to estradiol stimulus|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway|viral infectious cycle	extracellular space|Golgi lumen|nucleus|platelet alpha granule lumen|proteinaceous extracellular matrix	growth factor activity|type II transforming growth factor beta receptor binding				0					Hyaluronidase(DB00070)	AGGTCACCTCGGCGGCCGGTA	0.617			NA											7	28					0	0	0.00308	0	0
ATP1A3	478	broad.mit.edu	37	19	42471895	42471895	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:42471895C>A	uc002osg.2	-	21	2994	c.2840G>T	c.(2839-2841)GGG>GTG	p.G947V	ATP1A3_uc010xwf.1_Missense_Mutation_p.G958V|ATP1A3_uc010xwg.1_Missense_Mutation_p.G917V|ATP1A3_uc010xwh.1_Missense_Mutation_p.G960V|ATP1A3_uc002osh.2_Missense_Mutation_p.G947V	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	947	Helical; (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						CTCAAACAGCCCGAAGATCAG	0.667			NA											17	27					1.45105e-14	2.18819e-14	0.006122	1	0
PSG11	5680	broad.mit.edu	37	19	43523194	43523194	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:43523194G>A	uc002ovm.1	-	3	544	c.437C>T	c.(436-438)ACT>ATT	p.T146I	PSG11_uc002ouw.2_Missense_Mutation_p.T152I|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Missense_Mutation_p.T152I|PSG11_uc002ovn.1_Missense_Mutation_p.T152I|PSG11_uc002ovo.1_Missense_Mutation_p.T24I|PSG11_uc002ovp.1_Missense_Mutation_p.T24I	NM_002785	NP_002776	Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	146					female pregnancy	extracellular region					0		Prostate(69;0.00682)				GGGCTTGGGAGTCTCCACTGT	0.507			NA											81	185					0	0	0.00361	0	0
PRR12	57479	broad.mit.edu	37	19	50098435	50098435	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:50098435C>T	uc002poo.3	+	4	843	c.843C>T	c.(841-843)GCC>GCT	p.A281A		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CTGAGCGGGCCCTGCCACGCC	0.701			NA											8	10					0	0	0.006214	0	0
PRR12	57479	broad.mit.edu	37	19	50099244	50099244	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:50099244G>T	uc002poo.3	+	4	1652	c.1652G>T	c.(1651-1653)AGC>ATC	p.S551I		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		TGGGGACCCAGCTCCCTGGGA	0.711			NA											7	44					0.00621372	0.00651619	0.006214	1	0
NLRP12	91662	broad.mit.edu	37	19	54313064	54313064	+	Silent	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:54313064A>G	uc002qch.3	-	3	2069	c.1849T>C	c.(1849-1851)TTG>CTG	p.L617L	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Silent_p.L617L|NLRP12_uc002qcj.3_Silent_p.L617L|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Silent_p.L617L	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	617					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		ATCTCGTACAAGCAGCTGAAG	0.567			NA											29	56					0	0	0.002836	0	0
FCAR	2204	broad.mit.edu	37	19	55401191	55401191	+	Missense_Mutation	SNP	G	G	A	rs149025092		TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:55401191G>A	uc002qhr.1	+	5	1023	c.826G>A	c.(826-828)GGA>AGA	p.G276R	FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Missense_Mutation_p.G227R|FCAR_uc010esi.1_Missense_Mutation_p.G153R|FCAR_uc002qhu.1_Missense_Mutation_p.G180R|FCAR_uc002qhv.1_Missense_Mutation_p.G254R|FCAR_uc002qhw.1_Missense_Mutation_p.G264R|FCAR_uc002qhx.1_Missense_Mutation_p.G168R|FCAR_uc002qhy.1_Missense_Mutation_p.G242R|FCAR_uc002qhz.1_3'UTR|FCAR_uc002qia.1_Missense_Mutation_p.G167R	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	276	Cytoplasmic (Potential).				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		GTGTCAGCCAGGATTGACCTT	0.537			NA											30	118					0	0	0.007291	0	0
ZIM3	114026	broad.mit.edu	37	19	57648337	57648337	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:57648337G>T	uc002qnz.1	-	4	531	c.145C>A	c.(145-147)CAA>AAA	p.Q49K		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	49	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GTTTCCCCTTGTCCTGTGATG	0.348			NA											27	67					2.4375e-19	3.91871e-19	0.007291	1	0
ZNF324B	388569	broad.mit.edu	37	19	58966598	58966598	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:58966598G>C	uc002qsv.1	+	4	394	c.287G>C	c.(286-288)CGA>CCA	p.R96P	ZNF324B_uc002qsu.1_Missense_Mutation_p.R86P|ZNF324B_uc010euq.1_Missense_Mutation_p.R96P	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	96					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		GAATGGCCACGAGCTTTCCCA	0.557			NA											43	86					0	0	0.00361	0	0
TRIB2	28951	broad.mit.edu	37	2	12880652	12880652	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:12880652A>G	uc002rbv.3	+	3	2200	c.764A>G	c.(763-765)CAT>CGT	p.H255R	TRIB2_uc010yjp.1_Missense_Mutation_p.H119R	NM_021643	NP_067675	Q92519	TRIB2_HUMAN	tribbles homolog 2	255	Protein kinase.				negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			stomach(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TACCCTTTCCATGACATTGAA	0.572			NA											9	28					0	0	0.004482	0	0
APOB	338	broad.mit.edu	37	2	21224686	21224686	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:21224686C>T	uc002red.2	-	29	13736	c.13608G>A	c.(13606-13608)ACG>ACA	p.T4536T		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4536					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCAGTAACTCCGTGATGTATA	0.363			NA											7	127					0	0	0.001984	0	0
DNMT3A	1788	broad.mit.edu	37	2	25523106	25523106	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:25523106C>A	uc002rgc.2	-	3	336	c.79G>T	c.(79-81)GAG>TAG	p.E27*	DNMT3A_uc002rgd.2_Nonsense_Mutation_p.E27*|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rge.2_Nonsense_Mutation_p.E24*|DNMT3A_uc002rgf.2_Nonsense_Mutation_p.E27*	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	27					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCTGCTCCTCTCCGTCCTGC	0.682			NA	Mis|F|N|S		AML								5	19					0.00116845	0.00125679	0.001168	1	0
GTF3C2	2976	broad.mit.edu	37	2	27550111	27550111	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:27550111C>A	uc002rjv.1	-	19	2813	c.2450G>T	c.(2449-2451)CGC>CTC	p.R817L	MPV17_uc002rjt.2_5'Flank|GTF3C2_uc010eyy.1_Missense_Mutation_p.R272L|GTF3C2_uc002rju.1_Missense_Mutation_p.R828L|GTF3C2_uc002rjw.1_Missense_Mutation_p.R817L	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	817						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTCCTGCATGCGCAGCATTGG	0.498			NA											5	39					1.23904e-05	1.46662e-05	0.000602	1	0
C2orf71	388939	broad.mit.edu	37	2	29294243	29294243	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:29294243T>A	uc002rmt.1	-	1	2885	c.2885A>T	c.(2884-2886)CAC>CTC	p.H962L		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	962					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						AGGGCCGGAGTGGTGCCAGGC	0.647			NA											4	57					0	0	0.009096	0	0
ALK	238	broad.mit.edu	37	2	29449807	29449807	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:29449807C>A	uc002rmy.2	-	18	3955	c.3048G>T	c.(3046-3048)GAG>GAT	p.E1016D		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	1016	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	AGACGCCATCCTCAGCCAGCA	0.557			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				50	108					3.50607e-19	5.62463e-19	0.00361	1	0
LRRTM1	347730	broad.mit.edu	37	2	80530395	80530395	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:80530395A>C	uc002sok.1	-	2	820	c.550T>G	c.(550-552)TGC>GGC	p.C184G	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	184	Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						AGGCTGCGGCAGTCCTGGAAG	0.612			NA								HNSCC(69;0.2)			10	60					0	0	0.008291	0	0
ST3GAL5	8869	broad.mit.edu	37	2	86088367	86088367	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:86088367T>A	uc002sqq.1	-	3	384	c.255A>T	c.(253-255)TTA>TTT	p.L85F	ST3GAL5_uc010ysy.1_Missense_Mutation_p.L85F|ST3GAL5_uc010ysz.1_Missense_Mutation_p.L85F|ST3GAL5_uc010fgq.1_5'UTR|ST3GAL5_uc002sqp.1_Missense_Mutation_p.L62F	NM_003896	NP_003887	Q9UNP4	SIAT9_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	85	Lumenal (Potential).				ganglioside biosynthetic process|protein glycosylation	integral to Golgi membrane|integral to plasma membrane	lactosylceramide alpha-2,3-sialyltransferase activity|neolactotetraosylceramide alpha-2,3-sialyltransferase activity				0						TAGTATAATTTAACTTGAGGA	0.333			NA											30	53					0	0	0.002096	0	0
IMMT	10989	broad.mit.edu	37	2	86378436	86378436	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:86378436G>C	uc002sqz.3	-	12	1773	c.1385C>G	c.(1384-1386)GCT>GGT	p.A462G	IMMT_uc002sqy.3_Missense_Mutation_p.A203G|IMMT_uc002srb.3_Missense_Mutation_p.A451G|IMMT_uc002sra.3_Missense_Mutation_p.A461G|IMMT_uc010ytd.1_Missense_Mutation_p.A450G|IMMT_uc010yte.1_Missense_Mutation_p.A415G|IMMT_uc002src.1_Missense_Mutation_p.A198G	NM_006839	NP_006830	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial isoform 1	462	Mitochondrial intermembrane (Potential).					integral to mitochondrial inner membrane	protein binding			skin(1)	1						GTCCTGTTCAGCCTGTATTTC	0.378			NA											3	43					0	0	0.004672	0	0
MRPS5	64969	broad.mit.edu	37	2	95753185	95753185	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:95753185C>A	uc002sub.2	-	12	1428	c.1210G>T	c.(1210-1212)GTC>TTC	p.V404F	MRPS5_uc002suc.2_RNA	NM_031902	NP_114108	P82675	RT05_HUMAN	mitochondrial ribosomal protein S5	404					translation	mitochondrion|ribosome	protein binding|RNA binding|structural constituent of ribosome			ovary(2)|central_nervous_system(1)	3						TCCAGTTTGACGTCTGGAACC	0.567			NA											13	52					1.49906e-05	1.76884e-05	0.00245	1	0
INHBB	3625	broad.mit.edu	37	2	121107445	121107445	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:121107445G>T	uc002tmn.2	+	2	1265	c.1219G>T	c.(1219-1221)GCC>TCC	p.A407S		NM_002193	NP_002184	P09529	INHBB_HUMAN	inhibin beta B subunit preproprotein	407					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			pancreas(2)|skin(1)	3		Prostate(154;0.122)				GTGCGGCTGCGCCTGACAGTG	0.637			NA											10	25					1.76689e-08	2.32097e-08	0.006214	1	0
GLI2	2736	broad.mit.edu	37	2	121747560	121747560	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:121747560G>T	uc010flp.2	+	13	4100	c.4070G>T	c.(4069-4071)GGC>GTC	p.G1357V	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Missense_Mutation_p.G1029V|GLI2_uc002tmu.3_Missense_Mutation_p.G1012V	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1357					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				CCCCAAACAGGCCCGATGGGG	0.692			NA											10	10					0.000978159	0.00105815	0.000978	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125175123	125175123	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:125175123G>T	uc002tno.2	+	4	849	c.485G>T	c.(484-486)AGT>ATT	p.S162I	CNTNAP5_uc010flu.2_Missense_Mutation_p.S162I	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	162	F5/8 type C.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGGAATCCCAGTGGGAAGATT	0.502			NA											3	25					0.004672	0.00490625	0.004672	1	0
PLEKHB2	55041	broad.mit.edu	37	2	131883344	131883344	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:131883344G>T	uc002tsg.3	+	3	616	c.56G>T	c.(55-57)TGG>TTG	p.W19L	PLEKHB2_uc002tsh.2_Missense_Mutation_p.W19L|PLEKHB2_uc002tsj.3_Missense_Mutation_p.W19L|PLEKHB2_uc002tsf.3_Missense_Mutation_p.W19L|PLEKHB2_uc010zao.1_5'UTR|PLEKHB2_uc010zap.1_Missense_Mutation_p.W19L|PLEKHB2_uc010zaq.1_Missense_Mutation_p.W19L|PLEKHB2_uc002tsi.3_Missense_Mutation_p.W60L	NM_001100623	NP_001094093	Q96CS7	PKHB2_HUMAN	pleckstrin homology domain containing, family B	19	PH.					membrane	protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.0828)		TTGAAGCGCTGGAAGAAGAAC	0.308			NA											16	70					7.05477e-17	1.09903e-16	0.00499	1	0
LOC401010	401010	broad.mit.edu	37	2	132201106	132201106	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:132201106G>T	uc002tst.2	-	1	1362	c.896C>A	c.(895-897)CCA>CAA	p.P299Q		NR_002826				SubName: Full=cDNA FLJ12694 fis, clone NT2RP1000358, highly similar to Homo sapiens mRNA; cDNA DKFZp564C186 (from clone DKFZp564C186);												0						CATTCGCAGTGGGTAGAAGCG	0.597			NA											4	14					0.00024832	0.000277794	0.009096	1	0
YSK4	80122	broad.mit.edu	37	2	135738894	135738894	+	Silent	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:135738894G>A	uc002tue.1	-	9	3448	c.3417C>T	c.(3415-3417)TTC>TTT	p.F1139F	YSK4_uc002tuf.1_Silent_p.F321F|YSK4_uc010fnc.1_Silent_p.F273F|YSK4_uc010fnd.1_Silent_p.F1026F|YSK4_uc010zbg.1_Silent_p.F271F|YSK4_uc002tuh.3_Silent_p.F867F|YSK4_uc002tui.3_3'UTR	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	1139	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		CAAACTCCATGAAAATGCTCA	0.408			NA											13	154					0	0	0.001368	0	0
LRP1B	53353	broad.mit.edu	37	2	141526889	141526889	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:141526889G>A	uc002tvj.1	-	35	6623	c.5651C>T	c.(5650-5652)TCT>TTT	p.S1884F		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1884	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTCATGAACAGAGTACATAAG	0.388	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			19	51					0	0	0.008871	0	0
RIF1	55183	broad.mit.edu	37	2	152320091	152320091	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:152320091G>C	uc002txm.2	+	30	4187	c.4057G>C	c.(4057-4059)GAC>CAC	p.D1353H	RIF1_uc002txl.2_Missense_Mutation_p.D1353H|RIF1_uc002txn.2_Missense_Mutation_p.D1353H|RIF1_uc002txo.2_Missense_Mutation_p.D1353H|RIF1_uc002txp.2_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	1353					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		AATGGAGCATGACAATACAAA	0.343			NA											21	66					0	0	0.008871	0	0
B3GALT1	8708	broad.mit.edu	37	2	168726357	168726357	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:168726357C>A	uc002udz.1	+	2	1159	c.808C>A	c.(808-810)CTG>ATG	p.L270M		NM_020981	NP_066191	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta	270	Lumenal (Potential).				lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4						ATATGTGGGACTGTGTCTTCG	0.473			NA											23	67					1.55795e-14	2.34469e-14	0.001882	1	0
MAP1D	254042	broad.mit.edu	37	2	172942530	172942530	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:172942530T>A	uc002uhk.2	+	7	783	c.710T>A	c.(709-711)ATA>AAA	p.I237K	MAP1D_uc010zdw.1_Missense_Mutation_p.I119K	NM_199227	NP_954697	Q6UB28	AMP1D_HUMAN	methionine aminopeptidase 1D precursor	237					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis	mitochondrion	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			TAAAGCCACATAACTCATCAG	0.303			NA											8	66					0	0	0.00308	0	0
CDCA7	83879	broad.mit.edu	37	2	174223566	174223566	+	Splice_Site	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:174223566G>T	uc002uid.1	+	2	278	c.147_splice	c.e2+1	p.T49_splice	CDCA7_uc002uic.1_Splice_Site_p.T49_splice|CDCA7_uc010zej.1_Splice_Site_p.T49_splice|CDCA7_uc010zek.1_Intron	NM_145810	NP_665809	Q9BWT1	CDCA7_HUMAN	cell division cycle associated 7 isoform 2						regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.116)			TGCAAACACGGTAAGTGCTGC	0.403			NA											19	67					2.94398e-08	3.85376e-08	0.007413	1	0
KIAA1715	80856	broad.mit.edu	37	2	176794796	176794796	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:176794796C>G	uc002ukc.1	-	13	1379	c.1186G>C	c.(1186-1188)GAG>CAG	p.E396Q	KIAA1715_uc010zer.1_Missense_Mutation_p.E427Q|KIAA1715_uc010fqw.1_Missense_Mutation_p.E462Q|KIAA1715_uc010zes.1_Missense_Mutation_p.E398Q|KIAA1715_uc002ukd.1_Missense_Mutation_p.E273Q|KIAA1715_uc010zet.1_RNA	NM_030650	NP_085153	Q9C0E8	LNP_HUMAN	Lunapark	396	Cytoplasmic (Potential).					integral to membrane	protein binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0793)			TCCTCATTCTCAGTCTCTTGT	0.438			NA											21	91					0	0	0.010504	0	0
TTN	7273	broad.mit.edu	37	2	179437771	179437771	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:179437771G>T	uc010zfg.1	-	275	65608	c.65384C>A	c.(65383-65385)GCC>GAC	p.A21795D	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.A15490D|TTN_uc010zfi.1_Missense_Mutation_p.A15423D|TTN_uc010zfj.1_Missense_Mutation_p.A15298D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22722							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTGGCAGGGCAATCTCAAC	0.448			NA											4	27					0.00909568	0.00944648	0.009096	1	0
TTN	7273	broad.mit.edu	37	2	179462456	179462456	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:179462456C>A	uc010zfg.1	-	243	49873	c.49649G>T	c.(49648-49650)GGA>GTA	p.G16550V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G10245V|TTN_uc010zfi.1_Missense_Mutation_p.G10178V|TTN_uc010zfj.1_Missense_Mutation_p.G10053V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17477							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGAGGCTTTCCAGACACATA	0.483			NA											7	69					0.00198382	0.0021157	0.001984	1	0
TTN	7273	broad.mit.edu	37	2	179543515	179543515	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:179543515G>T	uc010zfg.1	-	140	30277	c.30053C>A	c.(30052-30054)CCA>CAA	p.P10018Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P6679Q|TTN_uc010fre.1_Missense_Mutation_p.P675Q|TTN_uc002una.1_RNA|TTN_uc010frf.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10945							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACTGGTACTGGTACTTTCTC	0.368			NA											15	71					4.14922e-12	5.95907e-12	0.004007	1	0
TTN	7273	broad.mit.edu	37	2	179599525	179599525	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:179599525C>T	uc010zfg.1	-	48	11618	c.11394G>A	c.(11392-11394)ACG>ACA	p.T3798T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.T459T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4725							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTTACATCCGTAATATCAA	0.373			NA											12	102					0	0	0.000978	0	0
TTN	7273	broad.mit.edu	37	2	179639156	179639156	+	Missense_Mutation	SNP	G	G	T	rs143679901	by1000genomes	TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:179639156G>T	uc010zfg.1	-	30	7059	c.6835C>A	c.(6835-6837)CCA>ACA	p.P2279T	TTN_uc010zfh.1_Missense_Mutation_p.P2233T|TTN_uc010zfi.1_Missense_Mutation_p.P2233T|TTN_uc010zfj.1_Missense_Mutation_p.P2233T|TTN_uc002unb.2_Missense_Mutation_p.P2279T|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2279							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATGATTCTGGAACTTCTATG	0.348			NA											7	67					8.12818e-05	9.28583e-05	0.001984	1	0
TTN	7273	broad.mit.edu	37	2	179647564	179647564	+	Silent	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:179647564G>C	uc010zfg.1	-	18	3293	c.3069C>G	c.(3067-3069)ACC>ACG	p.T1023T	TTN_uc010zfh.1_Silent_p.T977T|TTN_uc010zfi.1_Silent_p.T977T|TTN_uc010zfj.1_Silent_p.T977T|TTN_uc002unb.2_Silent_p.T1023T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1023							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGTGCTGACGGTTCCAGCCT	0.498			NA											8	52					0	0	0.00308	0	0
FAM171B	165215	broad.mit.edu	37	2	187558970	187558970	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:187558970C>G	uc002ups.2	+	1	182	c.70C>G	c.(70-72)CGG>GGG	p.R24G	FAM171B_uc002upr.1_Missense_Mutation_p.R24G	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	24						integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						GCTGAAAGCGCGGCTGGTCCC	0.557			NA											4	18					0	0	0.009096	0	0
DNAH7	56171	broad.mit.edu	37	2	196723505	196723505	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:196723505C>A	uc002utj.3	-	43	7861	c.7760G>T	c.(7759-7761)AGA>ATA	p.R2587I		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2587	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CACTTCATATCTCTTTTTCAT	0.373			NA											24	103					6.36457e-07	7.90591e-07	0.003954	1	0
PLCL1	5334	broad.mit.edu	37	2	198966032	198966032	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:198966032C>A	uc010fsp.2	+	4	3234	c.2943C>A	c.(2941-2943)CTC>CTA	p.L981L	PLCL1_uc002uuv.3_Silent_p.L902L	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	981					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	GCCGGTTTCTCATAGAAATGG	0.333			NA											19	108					2.37509e-13	3.50454e-13	0.010504	1	0
SGOL2	151246	broad.mit.edu	37	2	201436296	201436296	+	Silent	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:201436296G>A	uc002uvw.2	+	7	1340	c.1227G>A	c.(1225-1227)AAG>AAA	p.K409K	SGOL2_uc010zhd.1_Silent_p.K409K|SGOL2_uc010zhe.1_Silent_p.K409K	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	409					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						CTGAAAAAAAGAGAGAAAGAT	0.328			NA											6	59					0	0	0.00308	0	0
FZD7	8324	broad.mit.edu	37	2	202900716	202900716	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:202900716G>T	uc002uyw.1	+	1	1407	c.1346G>T	c.(1345-1347)CGT>CTT	p.R449L		NM_003507	NP_003498	O75084	FZD7_HUMAN	frizzled 7 precursor	449	Cytoplasmic (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(2)|ovary(1)|breast(1)	4						TCCCTCTTCCGTATCCGCACC	0.612			NA									OREG0015146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	95					0.000219431	0.000247311	0.00245	1	0
NRP2	8828	broad.mit.edu	37	2	206617582	206617582	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:206617582G>A	uc002vaw.2	+	12	2718	c.1927G>A	c.(1927-1929)GGA>AGA	p.G643R	NRP2_uc002vau.2_Missense_Mutation_p.G643R|NRP2_uc002vav.2_Missense_Mutation_p.G643R|NRP2_uc002vax.2_Missense_Mutation_p.G643R|NRP2_uc002vay.2_Missense_Mutation_p.G643R	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	643	Extracellular (Potential).|MAM.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GCTCCCTTCGGGATTCAATTG	0.488			NA											11	36					0	0	0.008291	0	0
CPO	130749	broad.mit.edu	37	2	207827201	207827201	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:207827201G>T	uc002vby.2	+	7	686	c.640G>T	c.(640-642)GAG>TAG	p.E214*		NM_173077	NP_775100	Q8IVL8	CBPO_HUMAN	carboxypeptidase O precursor	214					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				LUSC - Lung squamous cell carcinoma(261;0.0744)|Epithelial(149;0.0807)|Lung(261;0.142)		GTCTGAACCAGAGACTAAAGC	0.453			NA											38	111					9.73076e-26	1.64138e-25	0.006999	1	0
PLEKHM3	389072	broad.mit.edu	37	2	208841503	208841503	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:208841503G>C	uc002vcl.2	-	3	1908	c.1418C>G	c.(1417-1419)CCC>CGC	p.P473R	PLEKHM3_uc002vcm.2_Missense_Mutation_p.P473R	NM_001080475	NP_001073944	Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M,	473					intracellular signal transduction		metal ion binding			ovary(1)	1						TTGATCCTTGGGTTTGTTCCT	0.502			NA											7	43					0	0	0.001984	0	0
MAP2	4133	broad.mit.edu	37	2	210558713	210558713	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:210558713G>A	uc002vde.1	+	7	2067	c.1819G>A	c.(1819-1821)GAT>AAT	p.D607N	MAP2_uc002vdc.1_Missense_Mutation_p.D607N|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.D603N	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	607					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TGAGTCTATTGATACCATGTC	0.438	Pancreas(27;423 979 28787 29963)		NA											18	67					0	0	0.006122	0	0
ERBB4	2066	broad.mit.edu	37	2	212426632	212426632	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:212426632G>T	uc002veg.1	-	20	2581	c.2483C>A	c.(2482-2484)GCT>GAT	p.A828D	ERBB4_uc002veh.1_Missense_Mutation_p.A828D|ERBB4_uc010zji.1_Missense_Mutation_p.A818D|ERBB4_uc010zjj.1_Missense_Mutation_p.A818D|ERBB4_uc010fut.1_Missense_Mutation_p.A828D	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	828	Protein kinase.|Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		ACTTACCTTAGCTATCTGGAC	0.393			NA								TSP Lung(8;0.080)			13	87					0.00136819	0.00146954	0.001368	1	0
STK36	27148	broad.mit.edu	37	2	219563383	219563383	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:219563383G>T	uc002viu.2	+	26	3382	c.3116G>T	c.(3115-3117)CGC>CTC	p.R1039L	STK36_uc002viv.2_Missense_Mutation_p.R1018L|STK36_uc002viw.2_Missense_Mutation_p.R217L|STK36_uc002vix.2_Missense_Mutation_p.R84L	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	1039					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		CTTCTCACACGCCTGGCCCTC	0.537			NA											54	190					5.22555e-25	8.77521e-25	0.00361	1	0
WNT10A	80326	broad.mit.edu	37	2	219754997	219754997	+	Missense_Mutation	SNP	G	G	T	rs143424659		TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:219754997G>T	uc002vjd.1	+	3	1131	c.668G>T	c.(667-669)CGC>CTC	p.R223L		NM_025216	NP_079492	Q9GZT5	WN10A_HUMAN	wingless-type MMTV integration site family,	223					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|female gonad development|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentine-containing tooth|sebaceous gland development|skin development|tongue development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			lung(1)|skin(1)	2		Renal(207;0.0474)		Epithelial(149;4.26e-07)|all cancers(144;8.8e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTCGGGGAGCGCTTTTCTAAG	0.647			NA											9	31					7.48243e-07	9.21855e-07	0.006214	1	0
SCG2	7857	broad.mit.edu	37	2	224462640	224462640	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:224462640G>T	uc002vnm.2	-	2	1494	c.1361C>A	c.(1360-1362)CCC>CAC	p.P454H		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	454					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		ATATGGATTGGGAAAATACGA	0.478			NA											22	122					1.96292e-10	2.72568e-10	0.010504	1	0
RHBDD1	84236	broad.mit.edu	37	2	227729482	227729482	+	Missense_Mutation	SNP	A	A	T	rs147490611		TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:227729482A>T	uc002voi.2	+	2	194	c.73A>T	c.(73-75)AAC>TAC	p.N25Y	RHBDD1_uc010fxc.2_Missense_Mutation_p.N25Y	NM_032276	NP_115652	Q8TEB9	RHBD1_HUMAN	rhomboid domain containing 1	25	Helical; (Potential).					integral to membrane	serine-type endopeptidase activity			ovary(1)	1		Renal(207;0.023)|all_lung(227;0.13)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;1.47e-11)|all cancers(144;1.52e-08)|Lung(261;0.0128)|LUSC - Lung squamous cell carcinoma(224;0.0175)		TGTTGGGATCAACAATATTCC	0.458			NA											36	152					0	0	0.004289	0	0
CHRND	1144	broad.mit.edu	37	2	233398942	233398942	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:233398942C>T	uc002vsw.2	+	11	1265	c.1261C>T	c.(1261-1263)CCA>TCA	p.P421S	CHRND_uc010zmg.1_Missense_Mutation_p.P406S|CHRND_uc010fyc.2_Missense_Mutation_p.P294S|CHRND_uc010zmh.1_Missense_Mutation_p.P227S	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	421	Cytoplasmic (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		AGGCCGGCCCCCAGCAAGCTC	0.602			NA											14	55					0	0	0.003163	0	0
CHRNG	1146	broad.mit.edu	37	2	233406100	233406100	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:233406100G>A	uc002vsx.1	+	5	388	c.367G>A	c.(367-369)GAG>AAG	p.E123K	CHRNG_uc010fyd.2_Missense_Mutation_p.E123K|CHRNG_uc010fye.1_Intron	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma	123	Extracellular (Potential).				muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		CGGTGTCTTCGAGGTGGCCCT	0.637			NA											13	123					0	0	0.003163	0	0
UGT1A10	54575	broad.mit.edu	37	2	234545480	234545480	+	Silent	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:234545480T>C	uc002vur.2	+	1	358	c.312T>C	c.(310-312)AGT>AGC	p.S104S	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Silent_p.S104S	NM_019075	NP_061948	Q9HAW8	UD110_HUMAN	UDP glycosyltransferase 1 family, polypeptide	104					flavone metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding			ovary(2)|skin(1)	3		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		AGGCACAAAGTATATTTTCTC	0.378			NA											24	115					0	0	0.002299	0	0
COL6A3	1293	broad.mit.edu	37	2	238283178	238283178	+	Missense_Mutation	SNP	C	C	T	rs144976132		TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:238283178C>T	uc002vwl.2	-	8	3841	c.3556G>A	c.(3556-3558)GTG>ATG	p.V1186M	COL6A3_uc002vwo.2_Missense_Mutation_p.V980M|COL6A3_uc010znj.1_Missense_Mutation_p.V579M|COL6A3_uc002vwq.2_Missense_Mutation_p.V980M|COL6A3_uc002vwr.2_Missense_Mutation_p.V779M	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1186	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGAATGGCCACGGCAAAGTCC	0.622			NA											7	52					0	0	0.00308	0	0
RBM44	375316	broad.mit.edu	37	2	238725845	238725845	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:238725845C>T	uc002vxi.3	+	3	418	c.286C>T	c.(286-288)CAG>TAG	p.Q96*		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	95							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		TACTCAGTTTCAGTCAAGTGA	0.318			NA											16	47					0	0	0.003163	0	0
RBM44	375316	broad.mit.edu	37	2	238727007	238727007	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:238727007G>A	uc002vxi.3	+	3	1580	c.1448G>A	c.(1447-1449)AGG>AAG	p.R483K		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	482							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		ACAACCAGCAGGGCAACAAGT	0.388			NA											5	54					0	0	0.000602	0	0
PRR21	643905	broad.mit.edu	37	2	240982154	240982154	+	Silent	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:240982154G>C	uc010zod.1	-	1	246	c.246C>G	c.(244-246)CTC>CTG	p.L82L		NM_001080835	NP_001074304	Q8WXC7	PRR21_HUMAN	proline rich 21	82	Pro-rich.									ovary(1)|skin(1)	2						TGTGGGTGAAGAGCCGTGGAT	0.612			NA											16	83					0	0	0.007413	0	0
GPR35	2859	broad.mit.edu	37	2	241569824	241569824	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:241569824G>T	uc002vzs.1	+	1	1030	c.455G>T	c.(454-456)TGG>TTG	p.W152L	GPR35_uc010fzh.1_Missense_Mutation_p.W183L|GPR35_uc010fzi.1_Missense_Mutation_p.W183L	NM_005301	NP_005292	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	152	Helical; Name=4; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			skin(2)|pancreas(1)	3		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		GTGGCTCGCTGGCTCCTGGGG	0.701			NA											6	44					0.00198382	0.0021157	0.001984	1	0
RASSF2	9770	broad.mit.edu	37	20	4770300	4770300	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:4770300C>A	uc002wld.2	-	7	635	c.581G>T	c.(580-582)CGC>CTC	p.R194L	RASSF2_uc002wlc.2_RNA|RASSF2_uc002wle.2_RNA|RASSF2_uc002wlf.2_Missense_Mutation_p.R194L|RASSF2_uc010gbh.2_5'Flank	NM_170774	NP_739580	P50749	RASF2_HUMAN	Ras association domain family 2	194	Ras-associating.				cell cycle|signal transduction	nucleus	protein binding	p.R194H(1)		ovary(3)|lung(2)|large_intestine(1)	6						GCTGTTGATGCGGACGTTGGT	0.547	Melanoma(158;1891 3343 50738)		NA											11	58					3.07112e-06	3.69318e-06	0.000978	1	0
PROKR2	128674	broad.mit.edu	37	20	5294979	5294979	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:5294979T>G	uc010zqw.1	-	1	37	c.37A>C	c.(37-39)AAC>CAC	p.N13H	PROKR2_uc010zqx.1_Missense_Mutation_p.N13H|PROKR2_uc010zqy.1_Missense_Mutation_p.N13H|uc002wly.1_5'Flank	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	13	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GGATTAAAGTTGGGTGTGAAA	0.512			NA								HNSCC(71;0.22)			16	67					0	0	0.00499	0	0
PLCB1	23236	broad.mit.edu	37	20	8609055	8609055	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:8609055G>T	uc002wnb.2	+	4	364	c.361G>T	c.(361-363)GCT>TCT	p.A121S	PLCB1_uc010zrb.1_Missense_Mutation_p.A20S|PLCB1_uc010gbv.1_Missense_Mutation_p.A121S|PLCB1_uc002wmz.1_Missense_Mutation_p.A121S|PLCB1_uc002wna.2_Missense_Mutation_p.A121S|PLCB1_uc002wnc.1_Missense_Mutation_p.A20S	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	121					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						GAATCTCGTGGCTTTCCAAGA	0.473			NA											24	90					7.38237e-10	1.00113e-09	0.00632	1	0
C20orf7	79133	broad.mit.edu	37	20	13782241	13782241	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:13782241G>T	uc002wom.2	+	7	662	c.629G>T	c.(628-630)GGA>GTA	p.G210V	C20orf7_uc002wol.1_3'UTR|C20orf7_uc002won.2_Missense_Mutation_p.G182V|C20orf7_uc002woo.2_RNA	NM_024120	NP_077025	Q5TEU4	CT007_HUMAN	hypothetical protein LOC79133 isoform 1	210					mitochondrial respiratory chain complex I assembly	extrinsic to mitochondrial inner membrane	methyltransferase activity				0		Myeloproliferative disorder(85;0.00878)				GAAAGGGAAGGAGGATTTTCT	0.448			NA											18	50					3.41278e-10	4.68714e-10	0.00499	1	0
CST2	1470	broad.mit.edu	37	20	23805878	23805878	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:23805878C>T	uc002wtq.1	-	2	326	c.311G>A	c.(310-312)TGT>TAT	p.C104Y		NM_001322	NP_001313	P09228	CYTT_HUMAN	cystatin SA precursor	104						extracellular region	cysteine-type endopeptidase inhibitor activity				0						ATGGAAGGCACAGGTGTCCAA	0.547	Pancreas(193;496 3017 22514 29918)		NA											15	216					0	0	0.004007	0	0
C20orf118	140711	broad.mit.edu	37	20	35515916	35515916	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:35515916T>C	uc002xgg.1	+	5	505	c.497T>C	c.(496-498)ATG>ACG	p.M166T		NM_080628	NP_542195	A0PJX2	CT118_HUMAN	hypothetical protein LOC140711	166	TLD.										0		Myeloproliferative disorder(115;0.00874)				GATTCACTGATGATGGGCAGT	0.542			NA									OREG0025911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	111					0	0	0.001984	0	0
TOX2	84969	broad.mit.edu	37	20	42635233	42635233	+	Missense_Mutation	SNP	C	C	A	rs34581744		TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:42635233C>A	uc002xlf.3	+	3	256	c.239C>A	c.(238-240)CCG>CAG	p.P80Q	TOX2_uc010ggo.2_Missense_Mutation_p.P71Q|TOX2_uc002xle.3_Missense_Mutation_p.P29Q|TOX2_uc010ggp.2_Missense_Mutation_p.P29Q|TOX2_uc002xlg.2_Missense_Mutation_p.P29Q	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	80	Required for transcriptional activation (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			GAGATCCCCCCGATAACACCT	0.587			NA											22	110					1.28384e-07	1.6407e-07	0.001882	1	0
C20orf111	51526	broad.mit.edu	37	20	42825709	42825709	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:42825709C>G	uc002xlk.2	-	4	999	c.862G>C	c.(862-864)GAA>CAA	p.E288Q		NM_016470	NP_057554	Q9NX31	CT111_HUMAN	oxidative stress responsive 1	288											0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			TACATCATTTCTGCCATGTGG	0.418			NA											27	87					0	0	0.007291	0	0
R3HDML	140902	broad.mit.edu	37	20	42972100	42972100	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:42972100C>A	uc002xls.1	+	3	636	c.464C>A	c.(463-465)CCA>CAA	p.P155Q		NM_178491	NP_848586	Q9H3Y0	CRSPL_HUMAN	R3H domain containing-like precursor	155						extracellular region	peptidase inhibitor activity				0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			GACTGTAACCCACACTGCCCC	0.622			NA											17	56					4.63292e-17	7.27755e-17	0.008871	1	0
HNF4A	3172	broad.mit.edu	37	20	43034773	43034773	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:43034773G>T	uc002xma.2	+	2	280	c.191G>T	c.(190-192)GGG>GTG	p.G64V	HNF4A_uc010zwo.1_Missense_Mutation_p.G55W|HNF4A_uc002xlt.2_Missense_Mutation_p.G42V|HNF4A_uc002xlu.2_Missense_Mutation_p.G42V|HNF4A_uc002xlv.2_Missense_Mutation_p.G42V|HNF4A_uc002xly.2_Missense_Mutation_p.G64V|HNF4A_uc002xlz.2_Missense_Mutation_p.G64V|HNF4A_uc010ggq.2_Missense_Mutation_p.G57V	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	64	Nuclear receptor.|NR C4-type.				blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GCCATCTGCGGGGACCGGGCC	0.642	Colon(79;2 1269 8820 14841 52347)		NA											31	109					1.75199e-13	2.59019e-13	0.007291	1	0
MATN4	8785	broad.mit.edu	37	20	43926606	43926606	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:43926606C>G	uc002xnn.2	-	8	1718	c.1531G>C	c.(1531-1533)GGC>CGC	p.G511R	MATN4_uc002xno.2_Missense_Mutation_p.G470R|MATN4_uc002xnp.2_Missense_Mutation_p.G429R|MATN4_uc010zwr.1_Missense_Mutation_p.G459R|MATN4_uc002xnr.1_Missense_Mutation_p.G511R	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	552	VWFA 2.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				GTCATGGTGCCGAAGTCCGGG	0.652			NA											12	37					0	0	0.00245	0	0
ZNF334	55713	broad.mit.edu	37	20	45129982	45129982	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:45129982G>A	uc002xsc.2	-	5	2180	c.1996C>T	c.(1996-1998)CGC>TGC	p.R666C	ZNF334_uc002xsa.2_Missense_Mutation_p.R689C|ZNF334_uc002xsb.2_Missense_Mutation_p.R628C|ZNF334_uc002xsd.2_Missense_Mutation_p.R628C|ZNF334_uc010ghl.2_Missense_Mutation_p.R665C	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	666	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				GATTTGTGGCGAAATGTTTTC	0.358			NA											21	99					0	0	0.002299	0	0
SULF2	55959	broad.mit.edu	37	20	46313316	46313316	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:46313316G>T	uc002xto.2	-	6	1077	c.747C>A	c.(745-747)AGC>AGA	p.S249R	SULF2_uc002xtr.2_Missense_Mutation_p.S249R|SULF2_uc002xtq.2_Missense_Mutation_p.S249R	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	249					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CGTAGTTGTAGCTCGGCGTGC	0.632			NA											18	33					1.01871e-10	1.42771e-10	0.008871	1	0
PREX1	57580	broad.mit.edu	37	20	47246139	47246139	+	Silent	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:47246139G>A	uc002xtw.1	-	37	4637	c.4614C>T	c.(4612-4614)GCC>GCT	p.A1538A	PREX1_uc002xtv.1_Silent_p.A835A	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	1538					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GCTCATCCAGGGCATTGATGG	0.642			NA											8	72					0	0	0.00308	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47587797	47587797	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:47587797G>T	uc002xtx.3	+	10	1483	c.1331G>T	c.(1330-1332)GGC>GTC	p.G444V		NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	444					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TCCAAAAACGGCGTCTCTTCA	0.438	Esophageal Squamous(176;1738 1974 26285 33069 35354)		NA											12	130					0.00185496	0.00198953	0.001855	1	0
CASS4	57091	broad.mit.edu	37	20	55027161	55027161	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:55027161C>T	uc002xxp.2	+	6	1154	c.929C>T	c.(928-930)CCT>CTT	p.P310L	CASS4_uc002xxq.3_Missense_Mutation_p.P310L|CASS4_uc002xxr.2_Missense_Mutation_p.P310L|CASS4_uc010zze.1_Missense_Mutation_p.P256L|CASS4_uc010gio.2_Intron	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	310					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						CCAGAAATTCCTTCTTATGGC	0.463			NA											25	53					0	0	0.004656	0	0
ATP5E	514	broad.mit.edu	37	20	57605379	57605379	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:57605379C>T	uc002yal.2	-	2	254	c.138G>A	c.(136-138)GTG>GTA	p.V46V		NM_001001977	NP_001001977	P56381	ATP5E_HUMAN	ATP synthase, H+ transporting, mitochondrial F1	46					respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0	all_lung(29;0.00711)		Colorectal(105;0.109)			TCTTTACTTTCACAATTTTTA	0.348			NA											8	55					0	0	0.00308	0	0
EDN3	1908	broad.mit.edu	37	20	57876558	57876558	+	Missense_Mutation	SNP	C	C	A	rs148646322		TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:57876558C>A	uc002yap.2	+	2	515	c.146C>A	c.(145-147)ACT>AAT	p.T49N	EDN3_uc002yao.1_Missense_Mutation_p.T49N|EDN3_uc002yaq.2_Missense_Mutation_p.T49N|EDN3_uc002yar.2_Missense_Mutation_p.T49N|EDN3_uc002yas.2_Missense_Mutation_p.T49N	NM_000114	NP_000105	P14138	EDN3_HUMAN	endothelin 3 isoform 1 preproprotein	49					cell surface receptor linked signaling pathway|inositol phosphate-mediated signaling|neutrophil chemotaxis|peptide hormone secretion|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of leukocyte chemotaxis|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space|soluble fraction	endothelin B receptor binding|hormone activity			skin(1)	1	all_lung(29;0.0115)					TGTGAAGAGACTGTGGCTGGC	0.682			NA											8	40					1.58986e-06	1.92726e-06	0.008291	1	0
CDH26	60437	broad.mit.edu	37	20	58560058	58560058	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:58560058C>T	uc002ybe.2	+	7	1011	c.711C>T	c.(709-711)ACC>ACT	p.T237T	CDH26_uc010zzy.1_RNA	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	237	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CCACATAGACCGCTCCTCAGT	0.433			NA											8	40					0	0	0.006214	0	0
BIRC7	79444	broad.mit.edu	37	20	61867617	61867617	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr20:61867617G>T	uc002yej.2	+	1	342	c.169G>T	c.(169-171)GGC>TGC	p.G57C	BIRC7_uc010gkc.1_Missense_Mutation_p.G57C|BIRC7_uc002yei.2_Missense_Mutation_p.G57C|hsa-mir-3196|MI0014241_5'Flank	NM_139317	NP_647478	Q96CA5	BIRC7_HUMAN	livin inhibitor of apoptosis isoform alpha	57					activation of JUN kinase activity|anti-apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytoplasm|nucleus	enzyme binding|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3	all_cancers(38;2.72e-09)					GCAGATCCTGGGCCAGCTGCG	0.701			NA											5	18					0.00116845	0.00125679	0.001168	1	0
TPTE	7179	broad.mit.edu	37	21	10970061	10970061	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr21:10970061G>T	uc002yip.1	-	6	435	c.67C>A	c.(67-69)CCA>ACA	p.P23T	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.P23T|TPTE_uc002yir.1_Missense_Mutation_p.P23T|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	23					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTTGTCTGTGGACTAGTGGAT	0.373			NA											19	152					5.03518e-11	7.13633e-11	0.007413	1	0
JAM2	58494	broad.mit.edu	37	21	27071170	27071170	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr21:27071170G>A	uc002ylp.1	+	5	1121	c.576G>A	c.(574-576)ATG>ATA	p.M192I	JAM2_uc011ace.1_Missense_Mutation_p.M192I|JAM2_uc002ylq.1_RNA|JAM2_uc011acf.1_Missense_Mutation_p.M156I|JAM2_uc010glh.1_RNA|JAM2_uc002ylr.1_Missense_Mutation_p.M192I|JAM2_uc010gli.1_Missense_Mutation_p.M192I	NM_021219	NP_067042	P57087	JAM2_HUMAN	junctional adhesion molecule 2 precursor	192	Extracellular (Potential).|Ig-like C2-type.				blood coagulation|cell-cell adhesion|leukocyte migration	integral to plasma membrane|tight junction					0						CATACACAATGAATACAAAAA	0.378			NA											18	81					0	0	0.010504	0	0
DSCAM	1826	broad.mit.edu	37	21	41561050	41561050	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr21:41561050C>A	uc002yyq.1	-	12	2924	c.2472G>T	c.(2470-2472)GAG>GAT	p.E824D	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	824	Ig-like C2-type 9.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGATTCGGTCCTCCTTCTCCC	0.517	Melanoma(134;970 1778 1785 21664 32388)		NA											38	93					1.67305e-13	2.47835e-13	0.00623	1	0
SLC5A4	6527	broad.mit.edu	37	22	32614704	32614704	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr22:32614704C>A	uc003ami.2	-	15	1779	c.1777G>T	c.(1777-1779)GAG>TAG	p.E593*		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	593	Cytoplasmic (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						CGTGATTTCTCAGGATAATCT	0.418			NA											28	42					2.79863e-10	3.86478e-10	0.004656	1	0
FAM19A5	25817	broad.mit.edu	37	22	49042449	49042449	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr22:49042449C>A	uc003bim.3	+	2	270	c.153C>A	c.(151-153)GAC>GAA	p.D51E	FAM19A5_uc003bio.3_Missense_Mutation_p.D44E	NM_001082967	NP_001076436	Q7Z5A7	F19A5_HUMAN	family with sequence similarity 19 (chemokine	51						extracellular region|integral to membrane				large_intestine(1)	1		all_cancers(38;2.95e-11)|all_epithelial(38;3.07e-10)|all_lung(38;2.89e-05)|Breast(42;0.000396)|Lung NSC(38;0.000471)|Ovarian(80;0.00934)|Lung SC(80;0.195)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0227)|BRCA - Breast invasive adenocarcinoma(115;0.119)		TGACCTTGGACCGGGACAGCA	0.657			NA											6	33					0.00116845	0.00125679	0.001168	1	0
ADM2	79924	broad.mit.edu	37	22	50921163	50921163	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr22:50921163G>A	uc003blj.2	+	2	543	c.278G>A	c.(277-279)CGA>CAA	p.R93Q	ADM2_uc011ary.1_Missense_Mutation_p.R93Q	NM_024866	NP_079142	Q7Z4H4	ADM2_HUMAN	adrenomedullin 2 precursor	93					positive regulation of angiogenesis	extracellular region	hormone activity				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TCGGGCCCCCGAAGACACTCG	0.692			NA											6	12					0	0	0.001984	0	0
CHL1	10752	broad.mit.edu	37	3	402006	402006	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:402006T>A	uc003bou.2	+	11	1428	c.1157T>A	c.(1156-1158)ATC>AAC	p.I386N	CHL1_uc003bot.2_Missense_Mutation_p.I402N|CHL1_uc003bow.1_Missense_Mutation_p.I386N|CHL1_uc011asi.1_Missense_Mutation_p.I402N	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	386	Ig-like C2-type 4.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CCCAGGGAAATCAGTTTTACC	0.388			NA											16	81					0	0	0.004007	0	0
CNTN4	152330	broad.mit.edu	37	3	2778005	2778005	+	Silent	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:2778005A>G	uc003bpc.2	+	4	383	c.162A>G	c.(160-162)GGA>GGG	p.G54G	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Silent_p.G54G	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	54	Ig-like C2-type 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AAGTTAAAGGAAATCCAAAAC	0.353			NA											9	84					0	0	0.004482	0	0
SYN2	6854	broad.mit.edu	37	3	12211287	12211287	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:12211287G>A	uc003bwm.2	+	14	1353	c.1189G>A	c.(1189-1191)GAA>AAA	p.E397K	SYN2_uc003bwl.1_Missense_Mutation_p.E397K|SYN2_uc003bwn.2_Missense_Mutation_p.E71K	NM_133625	NP_598328	Q92777	SYN2_HUMAN	synapsin II isoform IIa	397					neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			ovary(1)|central_nervous_system(1)	2						ACTGATTGGGGAACATCAGGT	0.532			NA											3	35					0	0	0.009096	0	0
C3orf20	84077	broad.mit.edu	37	3	14769948	14769948	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:14769948C>T	uc003byy.2	+	12	2097	c.1693C>T	c.(1693-1695)CTG>TTG	p.L565L	C3orf20_uc003byz.2_Silent_p.L443L|C3orf20_uc003bza.2_Silent_p.L443L|C3orf20_uc003bzb.1_Silent_p.L66L	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	565						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						GTTAACAGGTCTGTTTACCAT	0.493			NA											13	48					0	0	0.00245	0	0
TMEM89	440955	broad.mit.edu	37	3	48658349	48658349	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:48658349T>A	uc011bbo.1	-	2	406	c.406A>T	c.(406-408)ATC>TTC	p.I136F		NM_001008269	NP_001008270	A2RUT3	TMM89_HUMAN	transmembrane protein 89 precursor	136	Cytoplasmic (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;0.000286)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		TGGCCTTCGATGTGGACCAGG	0.607			NA											36	82					0	0	0.003755	0	0
PDZRN3	23024	broad.mit.edu	37	3	73434883	73434883	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:73434883G>T	uc003dpl.1	-	9	1668	c.1572C>A	c.(1570-1572)CAC>CAA	p.H524Q	PDZRN3_uc011bgh.1_Missense_Mutation_p.H181Q|PDZRN3_uc010hoe.1_Missense_Mutation_p.H222Q|PDZRN3_uc011bgf.1_Missense_Mutation_p.H241Q|PDZRN3_uc011bgg.1_Missense_Mutation_p.H244Q	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	524							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GCATGTCCATGTGCAGGTCAT	0.562			NA											21	67					7.88262e-20	1.28647e-19	0.00333	1	0
CCDC52	152185	broad.mit.edu	37	3	113187949	113187949	+	Silent	SNP	T	T	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:113187949T>G	uc003eag.3	-	8	1039	c.748A>C	c.(748-750)AGA>CGA	p.R250R	CCDC52_uc003eaf.3_RNA|CCDC52_uc003eah.1_Silent_p.R146R	NM_144718	NP_653319	Q8N0Z3	SPICE_HUMAN	coiled-coil domain containing 52	250					cell division|mitosis	centriole|spindle	protein binding				0						AACAAACCTCTTTGCTCCCCT	0.388			NA											20	52					0	0	0.008871	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125876333	125876333	+	Silent	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:125876333A>G	uc003eim.1	-	4	571	c.381T>C	c.(379-381)GAT>GAC	p.D127D	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Intron|ALDH1L1_uc003eio.2_5'Flank|ALDH1L1_uc010hsf.1_Silent_p.D153D|ALDH1L1_uc003eip.1_Silent_p.D36D|ALDH1L1_uc011bkj.1_5'UTR	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	127	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CCCCTTTCTTATCTCCGTGAA	0.587			NA											6	75					0	0	0.001168	0	0
EPHB1	2047	broad.mit.edu	37	3	134825299	134825299	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:134825299C>A	uc003eqt.2	+	4	1035	c.815C>A	c.(814-816)GCA>GAA	p.A272E	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_Missense_Mutation_p.Q161K|EPHB1_uc003equ.2_5'UTR	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	272	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						GCTTGCCCTGCAGGGACATTC	0.557			NA											15	32					1.5739e-10	2.19763e-10	0.004007	1	0
PCCB	5096	broad.mit.edu	37	3	135969287	135969287	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:135969287G>A	uc003eqy.1	+	1	121	c.70G>A	c.(70-72)GCG>ACG	p.A24T	PCCB_uc003eqz.1_Missense_Mutation_p.A24T|PCCB_uc011bmc.1_Missense_Mutation_p.A24T	NM_000532	NP_000523	P05166	PCCB_HUMAN	propionyl Coenzyme A carboxylase, beta	24					fatty acid beta-oxidation	mitochondrial matrix	ATP binding|propionyl-CoA carboxylase activity				0					Biotin(DB00121)|L-Valine(DB00161)	TCTCCGCGCCGCGGTCCGCAG	0.692			NA									OREG0015823	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	8					0	0	0.004672	0	0
C3orf72	401089	broad.mit.edu	37	3	138668464	138668464	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:138668464C>G	uc003esx.1	+	2	334	c.203C>G	c.(202-204)TCG>TGG	p.S68W	FOXL2_uc003esw.2_5'Flank|C3orf72_uc011bmr.1_5'UTR	NM_001040061	NP_001035150	Q6ZUU3	CC072_HUMAN	chromosome 3 open reading frame 72	68											0						GTCCGGCATTCGAAGGCTCAG	0.577			NA											39	39					0	0	0.00623	0	0
ZIC1	7545	broad.mit.edu	37	3	147128840	147128840	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:147128840C>T	uc003ewe.2	+	1	1660	c.941C>T	c.(940-942)GCG>GTG	p.A314V		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	314	C2H2-type 3.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						AAGGTCTTCGCGCGCTCCGAG	0.562			NA											31	44					0	0	0.009535	0	0
IGSF10	285313	broad.mit.edu	37	3	151155508	151155508	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:151155508G>A	uc011bod.1	-	6	6841	c.6841C>T	c.(6841-6843)CTC>TTC	p.L2281F	IGSF10_uc011bob.1_Missense_Mutation_p.L308F|IGSF10_uc011boc.1_Missense_Mutation_p.L260F	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2281	Ig-like C2-type 9.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GGGGCTGTGAGGAAAATATTG	0.433			NA											54	64					0	0	0.00361	0	0
SLC33A1	9197	broad.mit.edu	37	3	155571625	155571625	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:155571625C>A	uc003fan.3	-	1	543	c.162G>T	c.(160-162)GGG>GGT	p.G54G	SLC33A1_uc003fao.1_Silent_p.G54G	NM_004733	NP_004724	O00400	ACATN_HUMAN	acetyl-coenzyme A transporter	54	Cytoplasmic (Potential).				cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			ovary(2)|large_intestine(1)|pancreas(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TGCCGGTATCCCCCAGAAGAG	0.557			NA											23	49					2.52088e-20	4.13205e-20	0.00278	1	0
SHOX2	6474	broad.mit.edu	37	3	157823778	157823778	+	Silent	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:157823778A>G	uc003fbr.2	-	1	175	c.36T>C	c.(34-36)TTT>TTC	p.F12F	SHOX2_uc003fbs.2_Silent_p.F12F|SHOX2_uc010hvw.2_Silent_p.F12F	NM_006884	NP_006875	O60902	SHOX2_HUMAN	short stature homeobox 2 isoform a	12					nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			CTTTCTGGTCAAAAGACTTGG	0.627			NA											14	54					0	0	0.004007	0	0
BCHE	590	broad.mit.edu	37	3	165503972	165503972	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:165503972A>G	uc003fem.3	-	3	1805	c.1645T>C	c.(1645-1647)TTC>CTC	p.F549L	BCHE_uc003fen.3_RNA	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	549					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	GATGTCCAGAATCGACATTGT	0.358			NA											11	44					0	0	0.001368	0	0
NLGN1	22871	broad.mit.edu	37	3	173998697	173998697	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:173998697G>C	uc003fio.1	+	7	2499	c.2076G>C	c.(2074-2076)TTG>TTC	p.L692F	NLGN1_uc003fip.1_Missense_Mutation_p.L692F	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	709	Helical; (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			TGAACATCTTGGCCTTTGCAG	0.463			NA											47	55					0	0	0.00361	0	0
FXR1	8087	broad.mit.edu	37	3	180675674	180675675	+	Nonsense_Mutation	DNP	GA	GA	TT			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:180675674_180675675GA>TT	uc003fkq.2	+	10	970_971	c.948_949GA>TT	c.(946-951)GTGAGA>GTTTGA	p.R317*	FXR1_uc003fkp.2_Nonsense_Mutation_p.R232*|FXR1_uc003fkr.2_Nonsense_Mutation_p.R317*|FXR1_uc011bqj.1_Nonsense_Mutation_p.R231*|FXR1_uc003fks.2_Nonsense_Mutation_p.R231*|FXR1_uc011bqk.1_Nonsense_Mutation_p.R268*|FXR1_uc011bql.1_Nonsense_Mutation_p.R304*	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	317					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			TGGTTCGAGTGAGAATTGAAGG	0.322			NA											42	56					0	0	0.004672	0	0
MASP1	5648	broad.mit.edu	37	3	186943140	186943140	+	Silent	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:186943140G>A	uc003frh.1	-	13	2045	c.1713C>T	c.(1711-1713)ATC>ATT	p.I571I		NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform	571	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		CAGGCAGACAGATGGGCATCA	0.582			NA											63	66					0	0	0.00361	0	0
MUC4	4585	broad.mit.edu	37	3	195505836	195505836	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr3:195505836G>C	uc011bto.1	-	3	12691	c.12231C>G	c.(12229-12231)CAC>CAG	p.H4077Q	MUC4_uc003fva.2_5'Flank|MUC4_uc003fvb.2_5'Flank|MUC4_uc003fvc.2_5'Flank|MUC4_uc003fvd.2_5'Flank|MUC4_uc003fve.2_5'Flank|MUC4_uc010hzr.2_5'Flank|MUC4_uc011btf.1_Intron|MUC4_uc011btg.1_Intron|MUC4_uc011bth.1_Intron|MUC4_uc011bti.1_Intron|MUC4_uc011btj.1_Intron|MUC4_uc011btk.1_Intron|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Intron|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.597			NA											2	5					0	0	0.004672	0	0
CPZ	8532	broad.mit.edu	37	4	8605802	8605802	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:8605802G>T	uc003glm.2	+	4	722	c.596G>T	c.(595-597)CGG>CTG	p.R199L	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Missense_Mutation_p.R62L|CPZ_uc003glo.2_Missense_Mutation_p.R188L|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	199					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						GTGCTGAGGCGGACGGCCTCC	0.701			NA											3	10					0.004672	0.00490625	0.004672	1	0
ZNF518B	85460	broad.mit.edu	37	4	10446863	10446863	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:10446863A>G	uc003gmn.2	-	3	1577	c.1090T>C	c.(1090-1092)TTT>CTT	p.F364L		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	364					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						TCCAGCGGAAACAGTTTCAGA	0.423			NA											45	148					0	0	0.00361	0	0
LAP3	51056	broad.mit.edu	37	4	17585192	17585192	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:17585192G>T	uc003gph.1	+	5	628	c.466G>T	c.(466-468)GTG>TTG	p.V156L	LAP3_uc010ieg.2_Silent_p.R120R	NM_015907	NP_056991	P28838	AMPL_HUMAN	leucine aminopeptidase 3	156					proteolysis	nucleus	aminopeptidase activity|magnesium ion binding|manganese ion binding|metalloexopeptidase activity|zinc ion binding				0						GGAGGGAGCGGTGCTTGGTCT	0.527			NA											26	76					3.28513e-13	4.80968e-13	0.003954	1	0
GBA3	57733	broad.mit.edu	37	4	22748966	22748966	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:22748966G>T	uc003gqp.3	+	3	425	c.334G>T	c.(334-336)GTT>TTT	p.V112F	GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Missense_Mutation_p.V113F	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	112					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						AAAAAATGGGGTTACTCCCAT	0.368			NA											11	136					1.58986e-06	1.92726e-06	0.008291	1	0
FRYL	285527	broad.mit.edu	37	4	48536592	48536592	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:48536592C>G	uc003gyh.1	-	49	7280	c.6675G>C	c.(6673-6675)GAG>GAC	p.E2225D	FRYL_uc003gyg.1_Missense_Mutation_p.E921D|FRYL_uc003gyi.1_Missense_Mutation_p.E1113D|FRYL_uc003gyj.1_Missense_Mutation_p.E520D	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2225					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						TCTTTATGATCTCCAGATTAA	0.254			NA											3	35					0	0	0.009096	0	0
KIAA1211	57482	broad.mit.edu	37	4	57181839	57181839	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:57181839C>T	uc003hbk.2	+	8	2562	c.2171C>T	c.(2170-2172)GCC>GTC	p.A724V	KIAA1211_uc010iha.2_Missense_Mutation_p.A717V|KIAA1211_uc011bzz.1_Missense_Mutation_p.A634V|KIAA1211_uc003hbm.1_Missense_Mutation_p.A610V	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	724										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					ATTATGCCTGCCTGGCAGAAA	0.557			NA											14	73					0	0	0.003163	0	0
LPHN3	23284	broad.mit.edu	37	4	62812728	62812728	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:62812728C>A	uc010ihh.2	+	13	2485	c.2312C>A	c.(2311-2313)ACA>AAA	p.T771K	LPHN3_uc003hcq.3_Missense_Mutation_p.T771K|LPHN3_uc003hct.2_Missense_Mutation_p.T164K	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	758	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						GCTTTGTCCACAAATCATTCT	0.403			NA											20	200					2.39187e-15	3.64338e-15	0.008871	1	0
EPHA5	2044	broad.mit.edu	37	4	66467859	66467859	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:66467859C>A	uc003hcy.2	-	3	603	c.410G>T	c.(409-411)TGC>TTC	p.C137F	EPHA5_uc003hcx.2_Missense_Mutation_p.C68F|EPHA5_uc003hcz.2_Missense_Mutation_p.C137F|EPHA5_uc011cah.1_Missense_Mutation_p.C137F|EPHA5_uc011cai.1_Missense_Mutation_p.C137F|EPHA5_uc003hda.2_Missense_Mutation_p.C137F	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	137	Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						AAGGCTGTTGCAGTCCCGCAG	0.428			NA								TSP Lung(17;0.13)			20	83					2.98393e-07	3.77497e-07	0.00278	1	0
UGT2B11	10720	broad.mit.edu	37	4	70066400	70066400	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:70066400G>A	uc003heh.2	-	6	1357	c.1348C>T	c.(1348-1350)CAT>TAT	p.H450Y	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	450					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						GGTTGATCATGTTGAATTCTT	0.383			NA											27	88					0	0	0.00632	0	0
CSN2	1447	broad.mit.edu	37	4	70823394	70823394	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:70823394C>A	uc003hes.3	-	5	286	c.273G>T	c.(271-273)CTG>CTT	p.L91L	CSN2_uc003het.3_Silent_p.L90L	NM_001891	NP_001882	P05814	CASB_HUMAN	casein beta precursor	91					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity				0						GAGGGACAGGCAGCACCACAG	0.483			NA											16	114					1.99824e-07	2.54076e-07	0.00499	1	0
ENAM	10117	broad.mit.edu	37	4	71510364	71510364	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:71510364C>G	uc011caw.1	+	9	3502	c.3221C>G	c.(3220-3222)TCT>TGT	p.S1074C		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	1074					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			GGAACTCCATCTAGCGATGGA	0.443			NA											25	72					0	0	0.00278	0	0
SLC4A4	8671	broad.mit.edu	37	4	72432731	72432731	+	Silent	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:72432731A>G	uc003hfy.2	+	25	3324	c.3207A>G	c.(3205-3207)TCA>TCG	p.S1069S	SLC4A4_uc010iic.2_Missense_Mutation_p.H1037R|SLC4A4_uc010iib.2_Silent_p.S985S|SLC4A4_uc003hfz.2_Silent_p.S1069S|SLC4A4_uc003hgc.3_Silent_p.S1025S|SLC4A4_uc010iid.2_Silent_p.S273S	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	1069	Cytoplasmic (Potential).			S -> P (in Ref. 3; AAF21719).		basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			GAGAAAGATCACCAACATTCC	0.338			NA											11	48					0	0	0.000978	0	0
FRAS1	80144	broad.mit.edu	37	4	79300930	79300930	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:79300930A>T	uc003hlb.2	+	27	3783	c.3343A>T	c.(3343-3345)ATT>TTT	p.I1115F	FRAS1_uc003hkw.2_Missense_Mutation_p.I1115F	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1114	CSPG 1.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						GATCCTCCCAATTGGTTCAAT	0.438			NA											11	45					0	0	0.000978	0	0
MMRN1	22915	broad.mit.edu	37	4	90874520	90874520	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:90874520A>C	uc003hst.2	+	8	3709	c.3638A>C	c.(3637-3639)AAG>ACG	p.K1213T	MMRN1_uc010iku.2_Missense_Mutation_p.K516T|MMRN1_uc011cds.1_Missense_Mutation_p.K955T	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	1213	C1q.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		ATTCCAGCCAAGTTTCCCCCT	0.363			NA											22	64					0	0	0.002299	0	0
PDHA2	5161	broad.mit.edu	37	4	96761473	96761473	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:96761473G>T	uc003htr.3	+	1	235	c.172G>T	c.(172-174)GAG>TAG	p.E58*		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	58					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	CACTAGGGCGGAGGGGCTTAA	0.458			NA											7	49					2.0095e-06	2.43204e-06	0.001984	1	0
ADH7	131	broad.mit.edu	37	4	100348950	100348950	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:100348950C>A	uc003huv.1	-	5	679	c.580G>T	c.(580-582)GCT>TCT	p.A194S		NM_000673	NP_000664	P40394	ADH7_HUMAN	class IV alcohol dehydrogenase, mu or sigma	194					ethanol oxidation|fatty acid omega-oxidation|response to bacterium|response to ethanol|xenobiotic metabolic process	cytosol|soluble fraction	alcohol dehydrogenase activity, zinc-dependent|aldehyde oxidase activity|ethanol binding|receptor antagonist activity|retinol binding|retinol dehydrogenase activity			lung(2)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;1.75e-08)	NADH(DB00157)	TTAACAGCAGCGCCATATCCA	0.408			NA											6	45					1.06961e-07	1.37861e-07	0.00308	1	0
C4orf21	55345	broad.mit.edu	37	4	113524823	113524823	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:113524823C>A	uc003iau.2	-	10	3044	c.2833G>T	c.(2833-2835)GGA>TGA	p.G945*	C4orf21_uc003iaw.2_Nonsense_Mutation_p.G945*	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		GTAGCTGATCCTTTTACTTGA	0.368			NA											11	58					5.16669e-11	7.30897e-11	0.000978	1	0
FAT4	79633	broad.mit.edu	37	4	126241676	126241676	+	Silent	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:126241676G>C	uc003ifj.3	+	1	4110	c.4110G>C	c.(4108-4110)GGG>GGC	p.G1370G		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1370	Cadherin 13.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CAAACACTGGGAGTATTTTTC	0.368			NA											25	152					0	0	0.00333	0	0
PCDH10	57575	broad.mit.edu	37	4	134073223	134073223	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:134073223G>T	uc003iha.2	+	1	2754	c.1928G>T	c.(1927-1929)CGA>CTA	p.R643L	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.R643L	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	643	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		ACAGCACGCCGAGTCCCGGCC	0.667			NA											16	42					1.5739e-10	2.19763e-10	0.004007	1	0
TBC1D9	23158	broad.mit.edu	37	4	141555266	141555266	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:141555266A>C	uc010ioj.2	-	16	2854	c.2582T>G	c.(2581-2583)CTG>CGG	p.L861R		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	861						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				ATACTGTTCCAGGTAGGGCAG	0.552			NA											12	46					0	0	0.000978	0	0
PET112L	5188	broad.mit.edu	37	4	152682016	152682016	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:152682016C>G	uc003iml.2	-	1	131	c.119G>C	c.(118-120)AGG>ACG	p.R40T	PET112L_uc003imm.3_Missense_Mutation_p.R40T	NM_004564	NP_004555	O75879	GATB_HUMAN	PET112-like precursor	40						mitochondrion	ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|translation factor activity, nucleic acid binding				0	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)			L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GCTCTCTCCCCTAATCTGGTT	0.597			NA											13	51					0	0	0.00245	0	0
DCHS2	54798	broad.mit.edu	37	4	155250852	155250852	+	Silent	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:155250852G>T	uc003inw.2	-	11	2376	c.2376C>A	c.(2374-2376)ATC>ATA	p.I792I	DCHS2_uc003inx.2_Silent_p.I1247I	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	792	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CCACCCAATTGATTAACTCTC	0.552			NA											8	49					0.000442599	0.000486472	0.006214	1	0
MAP9	79884	broad.mit.edu	37	4	156294509	156294509	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:156294509G>A	uc003ios.2	-	4	524	c.260C>T	c.(259-261)TCA>TTA	p.S87L	MAP9_uc011cin.1_Missense_Mutation_p.S87L|MAP9_uc010iqa.1_RNA|MAP9_uc003iot.1_Missense_Mutation_p.S87L|MAP9_uc010iqb.1_Missense_Mutation_p.S15L	NM_001039580	NP_001034669	Q49MG5	MAP9_HUMAN	aster-associated protein	87					cell division|mitosis	cytoplasm|microtubule|spindle				ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		CAATAGTTTTGAAGGATTCTT	0.328			NA											8	38					0	0	0.00308	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156651382	156651382	+	Nonstop_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:156651382A>T	uc003iov.2	+	11	2608	c.2072A>T	c.(2071-2073)TAG>TTG	p.*691L	GUCY1A3_uc003iow.2_Nonstop_Mutation_p.*691L|GUCY1A3_uc010iqd.2_Nonstop_Mutation_p.*690L|GUCY1A3_uc003iox.2_Nonstop_Mutation_p.*691L|GUCY1A3_uc003ioz.2_Nonstop_Mutation_p.*456L|GUCY1A3_uc003ioy.2_Nonstop_Mutation_p.*691L|GUCY1A3_uc010iqe.2_Nonstop_Mutation_p.*456L|GUCY1A3_uc003ipa.2_RNA|GUCY1A3_uc003ipb.2_Nonstop_Mutation_p.*691L	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	691					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		GGAATAGATTAGCAACCTATA	0.388			NA											7	45					0	0	0.001984	0	0
FSTL5	56884	broad.mit.edu	37	4	162459336	162459336	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:162459336C>T	uc003iqh.2	-	10	1730	c.1294G>A	c.(1294-1296)GAC>AAC	p.D432N	FSTL5_uc003iqi.2_Missense_Mutation_p.D431N|FSTL5_uc010iqv.2_Missense_Mutation_p.D431N	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	432						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CTAGCAGAGTCTTCCACAAAA	0.403			NA											21	191					0	0	0.001882	0	0
NPY5R	4889	broad.mit.edu	37	4	164271597	164271597	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:164271597G>A	uc003iqn.2	+	4	354	c.172G>A	c.(172-174)GGG>AGG	p.G58R		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	58	Helical; Name=1; (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				TGGCTTTATGGGGAATCTACT	0.378	Melanoma(139;1287 1774 9781 19750 25599)		NA											25	156					0	0	0.003954	0	0
C4orf41	60684	broad.mit.edu	37	4	184606247	184606247	+	Silent	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:184606247G>A	uc003ivx.2	+	16	1754	c.1578G>A	c.(1576-1578)CTG>CTA	p.L526L	C4orf41_uc003ivw.2_Silent_p.L526L|C4orf41_uc010isc.2_Intron|C4orf41_uc003ivy.2_Silent_p.L132L	NM_021942	NP_068761	Q7Z392	CD041_HUMAN	hypothetical protein LOC60684 isoform a	526											0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.39e-26)|Epithelial(43;2.42e-22)|OV - Ovarian serous cystadenocarcinoma(60;6.85e-10)|GBM - Glioblastoma multiforme(59;6.71e-06)|Colorectal(24;9.67e-06)|STAD - Stomach adenocarcinoma(60;2.36e-05)|COAD - Colon adenocarcinoma(29;7.07e-05)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.171)		CTTCAACTCTGAAAGATGACC	0.294			NA											10	40					0	0	0.001368	0	0
MTNR1A	4543	broad.mit.edu	37	4	187455522	187455522	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:187455522C>A	uc003izd.1	-	2	392	c.374G>T	c.(373-375)CGC>CTC	p.R125L		NM_005958	NP_005949	P48039	MTR1A_HUMAN	melatonin receptor 1A	125	Cytoplasmic (Potential).				circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			ovary(1)|skin(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	GTAGCAGTAGCGGTTGATGGC	0.567			NA											10	28					2.17888e-05	2.56299e-05	0.006214	1	0
TRIP13	9319	broad.mit.edu	37	5	917141	917141	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:917141G>C	uc003jbr.2	+	13	1332	c.1222G>C	c.(1222-1224)GAG>CAG	p.E408Q		NM_004237	NP_004228	Q15645	PCH2_HUMAN	thyroid hormone receptor interactor 13	408					double-strand break repair|reciprocal meiotic recombination|synaptonemal complex assembly|transcription from RNA polymerase II promoter		ATP binding|identical protein binding|nucleoside-triphosphatase activity|transcription cofactor activity				0			Epithelial(17;0.00147)|OV - Ovarian serous cystadenocarcinoma(19;0.00271)|all cancers(22;0.00622)|Lung(60;0.165)			CGTCACCATAGAGGGGTTCCT	0.592			NA											12	77					0	0	0.001855	0	0
SDHAP3	728609	broad.mit.edu	37	5	1593264	1593264	+	Missense_Mutation	SNP	C	C	T	rs111700178	by1000genomes	TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:1593264C>T	uc010itg.1	-	2	273	c.196G>A	c.(196-198)GCA>ACA	p.A66T	SDHAP3_uc011cme.1_RNA					Homo sapiens cDNA clone IMAGE:40127561.												0						AGGGCACATGCCTGACCAAAG	0.552			NA											5	67					0	0	0.00308	0	0
C5orf38	153571	broad.mit.edu	37	5	2753469	2753469	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:2753469G>T	uc003jdc.2	+	3	521	c.404G>T	c.(403-405)CGC>CTC	p.R135L	C5orf38_uc011cmg.1_Missense_Mutation_p.R135L|C5orf38_uc011cmh.1_RNA|C5orf38_uc011cmi.1_RNA|C5orf38_uc011cmj.1_Intron	NM_178569	NP_848664	Q86SI9	CEI_HUMAN	hypothetical protein LOC153571 precursor	135						extracellular region					0				GBM - Glioblastoma multiforme(108;0.205)		GCAGGCTCCCGGTAGGCGCGG	0.657			NA											11	101					0.000978159	0.00105815	0.000978	1	0
ADAMTS16	170690	broad.mit.edu	37	5	5242206	5242206	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:5242206A>T	uc003jdl.2	+	17	2702	c.2564A>T	c.(2563-2565)TAC>TTC	p.Y855F	ADAMTS16_uc003jdk.1_Missense_Mutation_p.Y855F	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	855	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						GCCTGGGAATACTCCATGCCT	0.542			NA											4	74					0	0	0.000602	0	0
ADCY2	108	broad.mit.edu	37	5	7773086	7773086	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:7773086C>T	uc003jdz.1	+	18	2323	c.2256C>T	c.(2254-2256)TCC>TCT	p.S752S	ADCY2_uc011cmo.1_Silent_p.S572S	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	752	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding	p.S752F(1)		ovary(5)|pancreas(1)|skin(1)	7						TATCCTGTTCCGTGTTCCTGC	0.493			NA											23	234					0	0	0.00333	0	0
ROPN1L	83853	broad.mit.edu	37	5	10461347	10461347	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:10461347G>T	uc003jex.3	+	4	740	c.469G>T	c.(469-471)GAG>TAG	p.E157*		NM_031916	NP_114122	Q96C74	ROP1L_HUMAN	ropporin 1-like	157					ciliary or flagellar motility|signal transduction	cytoplasm|motile cilium	cAMP-dependent protein kinase regulator activity|protein binding			ovary(1)	1						GGACGATCCGGAGGGCGGGCC	0.567			NA											73	90					2.51111e-31	4.3426e-31	0.00361	1	0
CTNND2	1501	broad.mit.edu	37	5	11346640	11346640	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:11346640T>C	uc003jfa.1	-	9	1617	c.1472A>G	c.(1471-1473)TAT>TGT	p.Y491C	CTNND2_uc010itt.2_Missense_Mutation_p.Y400C|CTNND2_uc011cmy.1_Missense_Mutation_p.Y154C|CTNND2_uc011cmz.1_Missense_Mutation_p.Y58C|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.Y58C	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	491					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GCCGGCGGCATAGCTGGCCCT	0.657			NA											7	115					0	0	0.001984	0	0
CTNND2	1501	broad.mit.edu	37	5	11364993	11364993	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:11364993C>T	uc003jfa.1	-	8	1332	c.1187G>A	c.(1186-1188)CGA>CAA	p.R396Q	CTNND2_uc010itt.2_Missense_Mutation_p.R305Q|CTNND2_uc011cmy.1_Missense_Mutation_p.R59Q|CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_5'UTR	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	396	ARM 1.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GTATGAGGCTCGGGAACCAGC	0.488			NA											7	76					0	0	0.001984	0	0
TRIO	7204	broad.mit.edu	37	5	14481375	14481375	+	Silent	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:14481375G>T	uc003jff.2	+	44	6375	c.6369G>T	c.(6367-6369)CTG>CTT	p.L2123L	TRIO_uc003jfg.2_RNA|TRIO_uc003jfh.1_Silent_p.L1772L	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2123	DH 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					AGGCCAGCCTGGATACATCAG	0.468			NA											22	277					3.62473e-10	4.96016e-10	0.001882	1	0
FBXL7	23194	broad.mit.edu	37	5	15500789	15500789	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:15500789G>T	uc003jfn.1	+	1	485	c.4G>T	c.(4-6)GGC>TGC	p.G2C		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	2					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CTACAGGATGGGCGCGAACAA	0.697			NA											27	195					1.55811e-20	2.5651e-20	0.008361	1	0
CDH12	1010	broad.mit.edu	37	5	21783467	21783467	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:21783467T>A	uc010iuc.2	-	8	1851	c.1393A>T	c.(1393-1395)AGT>TGT	p.S465C	CDH12_uc011cno.1_Missense_Mutation_p.S425C|CDH12_uc003jgk.2_Missense_Mutation_p.S465C	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	465	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						CCATACTTACTAACTTTACTC	0.368			NA								HNSCC(59;0.17)			14	107					0	0	0.003163	0	0
CDH9	1007	broad.mit.edu	37	5	26885753	26885753	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:26885753C>T	uc003jgs.1	-	11	2021	c.1852G>A	c.(1852-1854)GCG>ACG	p.A618T	CDH9_uc011cnv.1_Missense_Mutation_p.A211T	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	618	Helical; (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						AGTAGAATCGCAACGAGAGCT	0.512	Melanoma(8;187 585 15745 40864 52829)		NA											5	41					0	0	0.000602	0	0
NPR3	4883	broad.mit.edu	37	5	32712470	32712470	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:32712470C>A	uc003jhv.2	+	1	806	c.588C>A	c.(586-588)CAC>CAA	p.H196Q	NPR3_uc010iuo.2_Intron|NPR3_uc011cnz.1_Intron|NPR3_uc003jhu.2_Missense_Mutation_p.H196Q	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	196	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	GCCACCACCACTGGAGCCGCG	0.642			NA											9	111					5.68852e-11	8.00214e-11	0.004482	1	0
PRLR	5618	broad.mit.edu	37	5	35066174	35066174	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:35066174A>C	uc003jjm.2	-	10	1416	c.886T>G	c.(886-888)TTG>GTG	p.L296V	PRLR_uc003jjg.1_Missense_Mutation_p.L296V|PRLR_uc003jjh.1_Intron|PRLR_uc003jji.1_Intron|PRLR_uc003jjj.1_Intron|PRLR_uc003jjk.1_Intron|PRLR_uc003jjl.3_Missense_Mutation_p.L195V	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	296	Cytoplasmic (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TGGCATCCCAAGGCACTCAGT	0.438			NA											6	82					0	0	0.001168	0	0
LIFR	3977	broad.mit.edu	37	5	38481840	38481840	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:38481840T>A	uc010ive.1	-	20	3483	c.3151A>T	c.(3151-3153)AAC>TAC	p.N1051Y	LIFR_uc003jli.2_Missense_Mutation_p.N1051Y	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	1051	Cytoplasmic (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					ATCTCACTGTTGCTGTCTATG	0.418	Melanoma(13;4 730 6426 9861 34751)		NA	T	PLAG1	salivary adenoma								139	126					0	0	0.00361	0	0
RICTOR	253260	broad.mit.edu	37	5	38950710	38950710	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:38950710C>G	uc003jlp.2	-	31	3264	c.3240G>C	c.(3238-3240)AAG>AAC	p.K1080N	RICTOR_uc003jlo.2_Missense_Mutation_p.K1080N|RICTOR_uc010ivf.2_Missense_Mutation_p.K795N	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1080					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					AATTTTTATCCTTTATGGGTC	0.383			NA											22	559					0	0	0.010504	0	0
FYB	2533	broad.mit.edu	37	5	39202342	39202342	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:39202342C>T	uc003jls.2	-	1	788	c.721G>A	c.(721-723)GCA>ACA	p.A241T	FYB_uc003jlt.2_Missense_Mutation_p.A241T|FYB_uc003jlu.2_Missense_Mutation_p.A241T|FYB_uc011cpl.1_Missense_Mutation_p.A251T	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	241					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			TCTTCCCTTGCTGGTTTTAAA	0.522			NA											238	84					0	0	0.00361	0	0
C9	735	broad.mit.edu	37	5	39341744	39341744	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:39341744G>T	uc003jlv.3	-	3	331	c.242C>A	c.(241-243)GCT>GAT	p.A81D		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	81	TSP type-1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			GTCTCCCACAGCGTCGGTGCA	0.448			NA											7	233					0.00198382	0.0021157	0.001984	1	0
C6	729	broad.mit.edu	37	5	41154099	41154099	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:41154099C>A	uc003jmk.2	-	15	2313	c.2103G>T	c.(2101-2103)CGG>CGT	p.R701R	C6_uc003jml.1_Silent_p.R701R	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	701	Sushi 1.|C5b-binding domain.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TGCACTCCGTCCCTGCAAGAG	0.393			NA											93	42					6.65942e-36	1.15963e-35	0.00361	1	0
GHR	2690	broad.mit.edu	37	5	42718570	42718570	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:42718570G>C	uc003jmt.2	+	10	1004	c.961G>C	c.(961-963)GAG>CAG	p.E321Q	GHR_uc011cpq.1_Missense_Mutation_p.E134Q	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	321	Cytoplasmic (Potential).				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	AAAATTAGAGGAGGTGAACAC	0.313			NA											54	172					0	0	0.00361	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79743953	79743953	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:79743953C>T	uc003kgr.3	+	8	3135	c.2833C>T	c.(2833-2835)CCA>TCA	p.P945S	ZFYVE16_uc003kgp.2_Missense_Mutation_p.P945S|ZFYVE16_uc003kgq.3_Missense_Mutation_p.P945S|ZFYVE16_uc003kgs.3_Missense_Mutation_p.P945S|ZFYVE16_uc003kgt.3_Intron	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	945					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		TTCTCAGGTTCCATCAGTGGA	0.383	Melanoma(150;1452 1854 16018 17851 37292)		NA											9	51					0	0	0.004482	0	0
DMXL1	1657	broad.mit.edu	37	5	118560423	118560423	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:118560423A>G	uc003ksd.2	+	37	8415	c.8234A>G	c.(8233-8235)AAT>AGT	p.N2745S	DMXL1_uc010jcl.1_Missense_Mutation_p.N2766S|DMXL1_uc010jcm.1_RNA	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2745	WD 11.									ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		AAAGCCATTAATAATGTTAGA	0.244			NA											10	52					0	0	0.000978	0	0
MEGF10	84466	broad.mit.edu	37	5	126792830	126792830	+	Silent	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:126792830G>T	uc003kuh.3	+	26	3605	c.3243G>T	c.(3241-3243)GTG>GTT	p.V1081V	MEGF10_uc003kui.3_Silent_p.V1081V	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	1081	Cytoplasmic (Potential).|Necessary for formation of large intracellular vacuoles.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		AACCTACAGTGAGTGTTGTCC	0.398			NA											5	75					1.024e-07	1.32435e-07	0.000602	1	0
FBN2	2201	broad.mit.edu	37	5	127800434	127800434	+	Missense_Mutation	SNP	C	C	A	rs148971572	byFrequency	TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:127800434C>A	uc003kuu.2	-	6	1248	c.809G>T	c.(808-810)CGC>CTC	p.R270L	FBN2_uc003kuv.2_Missense_Mutation_p.R237L|FBN2_uc003kuw.3_Missense_Mutation_p.R270L|FBN2_uc003kux.1_Missense_Mutation_p.R270L	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	270					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		AGCTCCAGTGCGGATGTTGGG	0.592			NA											9	57					7.48243e-07	9.21855e-07	0.006214	1	0
TIFAB	497189	broad.mit.edu	37	5	134785511	134785511	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:134785511C>T	uc003law.3	-	2	320	c.119G>A	c.(118-120)CGG>CAG	p.R40Q	C5orf20_uc003lav.2_5'Flank	NM_001099221	NP_001092691	Q6ZNK6	TIFAB_HUMAN	TIFA-related protein TIFAB	40	FHA.										0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTCCTGCCCCCGTCCGAGAAG	0.662			NA											4	56					0	0	0.009096	0	0
BRD8	10902	broad.mit.edu	37	5	137501538	137501538	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:137501538G>C	uc003lcf.1	-	11	1312	c.1257C>G	c.(1255-1257)ATC>ATG	p.I419M	BRD8_uc003lcc.1_RNA|BRD8_uc011cyl.1_Missense_Mutation_p.I198M|BRD8_uc003lcg.2_Missense_Mutation_p.I492M|BRD8_uc003lci.2_Missense_Mutation_p.I422M|BRD8_uc003lch.2_Missense_Mutation_p.I313M|BRD8_uc011cym.1_Missense_Mutation_p.I403M|BRD8_uc010jer.1_Missense_Mutation_p.I388M|BRD8_uc011cyn.1_Missense_Mutation_p.I378M	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	419					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TGATGGCAATGATGTCTCCAA	0.463			NA											5	85					0	0	0.000602	0	0
HARS2	23438	broad.mit.edu	37	5	140077256	140077256	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:140077256G>T	uc003lgx.2	+	11	1516	c.1300G>T	c.(1300-1302)GAT>TAT	p.D434Y	HARS2_uc011czr.1_Missense_Mutation_p.D409Y|HARS2_uc011czs.1_Missense_Mutation_p.D290Y|HARS2_uc011czt.1_Missense_Mutation_p.D262Y|HARS2_uc011czu.1_Missense_Mutation_p.D260Y|ZMAT2_uc003lgy.1_5'Flank	NM_012208	NP_036340	P49590	SYHM_HUMAN	histidyl-tRNA synthetase 2 precursor	434					histidyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|histidine-tRNA ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAGCTTTGGGATTCTGGAAT	0.473			NA											44	86					1.62263e-30	2.79329e-30	0.00361	1	0
PCDHA2	56146	broad.mit.edu	37	5	140175912	140175912	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:140175912T>A	uc003lhd.2	+	1	1469	c.1363T>A	c.(1363-1365)TTC>ATC	p.F455I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.F455I|PCDHA2_uc011czy.1_Missense_Mutation_p.F455I	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	455	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGCCGGCGTTCGCACAGCC	0.652			NA											28	62					0	0	0.007291	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202127	140202127	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:140202127G>T	uc003lhl.2	+	1	767	c.767G>T	c.(766-768)AGT>ATT	p.S256I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.S256I|PCDHA5_uc003lhj.1_Missense_Mutation_p.S256I	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	256	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATGCACCAAGTGGGACATTA	0.358			NA											30	58					2.42023e-17	3.81769e-17	0.003271	1	0
PCDHB6	56130	broad.mit.edu	37	5	140530172	140530172	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:140530172C>A	uc003lir.2	+	1	334	c.334C>A	c.(334-336)CCC>ACC	p.P112T	PCDHB6_uc011dah.1_5'UTR	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	112	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTGGAAAACCCCTTGCAGTT	0.473			NA											11	58					3.86212e-05	4.48006e-05	0.008291	1	0
PCDHGA3	56112	broad.mit.edu	37	5	140725511	140725511	+	Silent	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:140725511G>T	uc003ljm.1	+	1	1911	c.1911G>T	c.(1909-1911)GCG>GCT	p.A637A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Silent_p.A397A|PCDHGA3_uc011dap.1_Silent_p.A637A	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	637	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAGAGACGCGCTCAAGCAGA	0.701			NA											23	78					3.11337e-16	4.80058e-16	0.002836	1	0
PCDHGA4	56111	broad.mit.edu	37	5	140736090	140736090	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:140736090A>T	uc003ljq.1	+	1	1323	c.1323A>T	c.(1321-1323)CAA>CAT	p.Q441H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Missense_Mutation_p.Q441H	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	441	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTCACTGCAAGTGATGGACA	0.458			NA											22	73					0	0	0.002299	0	0
NIPAL4	348938	broad.mit.edu	37	5	156899856	156899856	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:156899856C>T	uc003lwx.3	+	6	1405	c.1289C>T	c.(1288-1290)CCG>CTG	p.P430L	ADAM19_uc003lww.1_Intron|NIPAL4_uc011ddq.1_Missense_Mutation_p.P411L	NM_001099287	NP_001092757	Q0D2K0	NIPA4_HUMAN	ichthyin protein	430	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						TCTCCCGCCCCGGAACCCACT	0.498			NA											12	22					0	0	0.000978	0	0
ATP10B	23120	broad.mit.edu	37	5	159992831	159992831	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:159992831G>T	uc003lym.1	-	26	4862	c.4015C>A	c.(4015-4017)CCA>ACA	p.P1339T	ATP10B_uc010jit.1_Missense_Mutation_p.P589T	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1339	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTTTTGTCTGGGGGGAGTTTG	0.478			NA											43	112					6.5261e-18	1.03159e-17	0.00874	1	0
GABRA6	2559	broad.mit.edu	37	5	161116110	161116110	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:161116110C>A	uc003lyu.2	+	4	719	c.381C>A	c.(379-381)CAC>CAA	p.H127Q	GABRA6_uc003lyv.2_5'Flank	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	127	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CCATTGCTCACAACATGACAA	0.398			NA								TCGA Ovarian(5;0.080)			12	47					6.40141e-05	7.38022e-05	0.000978	1	0
GABRG2	2566	broad.mit.edu	37	5	161524799	161524799	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:161524799C>A	uc003lyz.3	+	4	841	c.483C>A	c.(481-483)CAC>CAA	p.H161Q	GABRG2_uc010jjc.2_Missense_Mutation_p.H161Q|GABRG2_uc003lyy.3_Missense_Mutation_p.H161Q|GABRG2_uc011dej.1_Missense_Mutation_p.H66Q	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	161	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CTGATGCACACTGGATCACCA	0.428			NA											29	80					4.22769e-11	6.00317e-11	0.00632	1	0
ODZ2	57451	broad.mit.edu	37	5	167617539	167617539	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:167617539C>A	uc010jjd.2	+	14	2740	c.2740C>A	c.(2740-2742)CCT>ACT	p.P914T	ODZ2_uc003lzr.3_Missense_Mutation_p.P691T|ODZ2_uc003lzt.3_Missense_Mutation_p.P287T|ODZ2_uc010jje.2_Missense_Mutation_p.P185T|uc003lzs.1_5'Flank	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		TGGAGAGAACCCTTTCAACAG	0.547			NA											7	26					0.000157383	0.000177645	0.00308	1	0
DDX41	51428	broad.mit.edu	37	5	176943349	176943349	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr5:176943349C>T	uc003mho.2	-	3	259	c.238G>A	c.(238-240)GGC>AGC	p.G80S	DDX41_uc003mhm.2_5'Flank|DDX41_uc003mhn.2_5'UTR|DDX41_uc003mhp.2_5'UTR|DDX41_uc003mhq.1_5'UTR	NM_016222	NP_057306	Q9UJV9	DDX41_HUMAN	DEAD-box protein abstrakt	80					apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding				0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			GACTGAGGGCCTAGCGGGATG	0.612			NA											45	67					0	0	0.002852	0	0
BPHL	670	broad.mit.edu	37	6	3127533	3127533	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:3127533C>A	uc003mva.2	+	3	318	c.269C>A	c.(268-270)ACG>AAG	p.T90K	BPHL_uc003muz.2_RNA|BPHL_uc011dht.1_RNA|BPHL_uc003muy.2_Missense_Mutation_p.T73K	NM_004332	NP_004323	Q86WA6	BPHL_HUMAN	biphenyl hydrolase-like precursor	90					cellular amino acid metabolic process|response to toxin	mitochondrion	hydrolase activity				0	Ovarian(93;0.0386)	all_hematologic(90;0.108)				AAGCTCTTCACGGTGGTCGCC	0.493			NA											8	82					0.000157383	0.000177645	0.00308	1	0
SLC17A1	6568	broad.mit.edu	37	6	25820019	25820019	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:25820019A>G	uc003nfh.3	-	4	448	c.332T>C	c.(331-333)ATT>ACT	p.I111T	SLC17A1_uc011djy.1_RNA|SLC17A1_uc010jqb.1_Missense_Mutation_p.I109T|SLC17A1_uc010jqc.1_Missense_Mutation_p.I109T	NM_005074	NP_005065	Q14916	NPT1_HUMAN	solute carrier family 17 (sodium phosphate),	111					sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(3)|pancreas(1)	4						TGCAAAGCCAATCATTTTCTT	0.453			NA											13	80					0	0	0.001368	0	0
OR2J2	26707	broad.mit.edu	37	6	29141709	29141709	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:29141709G>T	uc011dlm.1	+	1	399	c.297G>T	c.(295-297)ATG>ATT	p.M99I		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTGGTTGCATGGTTCAACTTT	0.478			NA											49	195					3.4597e-24	5.79692e-24	0.00361	1	0
OR2J2	26707	broad.mit.edu	37	6	29141788	29141788	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:29141788G>C	uc011dlm.1	+	1	478	c.376G>C	c.(376-378)GCT>CCT	p.A126P		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	126	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCGTTATGTAGCTGTGTGTAG	0.453			NA											66	271					0	0	0.00361	0	0
MDC1	9656	broad.mit.edu	37	6	30673394	30673394	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:30673394C>A	uc003nrg.3	-	10	4006	c.3566G>T	c.(3565-3567)GGA>GTA	p.G1189V	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.G796V	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1189	Pro-rich.|Interaction with the PRKDC complex.			Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						ACTTTTTCTTCCCCTAGTAAC	0.572			NA						Other_conserved_DNA_damage_response_genes					25	303					5.35356e-11	7.54501e-11	0.00278	1	0
MDC1	9656	broad.mit.edu	37	6	30679203	30679203	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:30679203C>A	uc003nrg.3	-	7	2647	c.2207G>T	c.(2206-2208)AGC>ATC	p.S736I	MDC1_uc003nrf.3_Missense_Mutation_p.S390I|MDC1_uc011dmp.1_Missense_Mutation_p.S607I	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	736				Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						TGTCTGGAAGCTGCAATGGGA	0.418			NA						Other_conserved_DNA_damage_response_genes					11	38					0.000978159	0.00105815	0.000978	1	0
TNXB	7148	broad.mit.edu	37	6	32020721	32020721	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:32020721C>T	uc003nzl.2	-	26	9037	c.8835G>A	c.(8833-8835)CCG>CCA	p.P2945P		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2992					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CAGGGGGCTCCGGGGCCTCCG	0.657			NA											16	61					0	0	0.00499	0	0
TNXB	7148	broad.mit.edu	37	6	32025991	32025991	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:32025991T>A	uc003nzl.2	-	22	7871	c.7669A>T	c.(7669-7671)AAG>TAG	p.K2557*		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2617	Fibronectin type-III 18.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCCCTGTCCTTGTACTGCACG	0.652			NA											18	56					0	0	0.006122	0	0
PPT2	9374	broad.mit.edu	37	6	32123712	32123712	+	Silent	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:32123712T>C	uc003nzx.2	+	5	1066	c.498T>C	c.(496-498)TAT>TAC	p.Y166Y	PRRT1_uc003nzu.2_5'Flank|uc003nzv.3_5'Flank|PPT2_uc003nzw.2_Silent_p.Y172Y|PPT2_uc011dpi.1_RNA|PPT2_uc003nzy.1_RNA|PPT2_uc003nzz.2_Silent_p.Y166Y|PPT2_uc003oaa.2_Silent_p.Y166Y|PPT2_uc010jtu.1_Silent_p.Y166Y	NM_005155	NP_005146	Q9UMR5	PPT2_HUMAN	palmitoyl-protein thioesterase 2 isoform a	166					protein modification process	lysosome	palmitoyl-(protein) hydrolase activity				0						GGATCTGCTATAGCCCCTGGG	0.537			NA											10	99					0	0	0.000978	0	0
NOTCH4	4855	broad.mit.edu	37	6	32169993	32169993	+	Silent	SNP	C	C	A	rs61729678		TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:32169993C>A	uc003obb.2	-	21	3754	c.3615G>T	c.(3613-3615)CTG>CTT	p.L1205L	NOTCH4_uc003oba.2_5'UTR|NOTCH4_uc011dpu.1_Intron|NOTCH4_uc011dpv.1_Intron	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1205	LNR 1.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						CTGGGACTCCCAGAGAGCAGT	0.652			NA											18	71					3.32936e-07	4.19088e-07	0.006122	1	0
NOTCH4	4855	broad.mit.edu	37	6	32188604	32188604	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:32188604T>C	uc003obb.2	-	5	990	c.851A>G	c.(850-852)CAG>CGG	p.Q284R	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc003obc.2_Missense_Mutation_p.Q284R	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	284	EGF-like 7; calcium-binding (Potential).|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						ATTCTGACACTGGTGGCTGAC	0.557			NA											14	117					0	0	0.003163	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34825135	34825135	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:34825135G>T	uc003oju.3	+	12	1695	c.1461G>T	c.(1459-1461)AAG>AAT	p.K487N	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_5'Flank	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	487										ovary(3)	3						CAAGTAAAAAGCCATCTACAC	0.433			NA											23	75					1.37657e-19	2.22732e-19	0.001882	1	0
PNPLA1	285848	broad.mit.edu	37	6	36262158	36262158	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:36262158G>T	uc010jwf.2	+	4	696	c.696G>T	c.(694-696)TTG>TTT	p.L232F	PNPLA1_uc003olw.1_Missense_Mutation_p.L137F|PNPLA1_uc010jwe.1_Missense_Mutation_p.L146F	NM_001145717	NP_001139189	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	232					lipid catabolic process		hydrolase activity			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4						CCCACGCATTGTTCCCCCCGG	0.622			NA											24	57					5.45727e-16	8.38041e-16	0.008361	1	0
STK38	11329	broad.mit.edu	37	6	36489584	36489584	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:36489584A>T	uc003omg.2	-	4	905	c.317T>A	c.(316-318)GTT>GAT	p.V106D	STK38_uc003omh.2_Missense_Mutation_p.V106D|STK38_uc003omi.2_Missense_Mutation_p.V106D	NM_007271	NP_009202	Q15208	STK38_HUMAN	serine/threonine kinase 38	106	Protein kinase.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6						TTTCTTCTGAACAAGCCGTAC	0.358	Colon(180;997 3561 16158)		NA											12	61					0	0	0.001368	0	0
TFAP2D	83741	broad.mit.edu	37	6	50740545	50740545	+	Missense_Mutation	SNP	G	G	C	rs78823892		TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:50740545G>C	uc003paf.2	+	8	1839	c.1327G>C	c.(1327-1329)GTG>CTG	p.V443L	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	443							DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					AGAGGCTGCCGTGAAAGAGGG	0.453			NA											3	37					0	0	0.009096	0	0
IL17A	3605	broad.mit.edu	37	6	52054021	52054022	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:52054021_52054022CC>AA	uc003pak.1	+	3	444_445	c.399_400CC>AA	c.(397-402)TTCCGG>TTAAGG	p.F133L		NM_002190	NP_002181	Q16552	IL17_HUMAN	interleukin 17A precursor	133					apoptosis|cell-cell signaling|fibroblast activation|immune response|inflammatory response|positive regulation of interleukin-23 production|positive regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein glycosylation	extracellular space	cytokine activity				0	Lung NSC(77;0.116)					CCAACTCCTTCCGGCTGGAGAA	0.599			NA											12	66					0	0	0.004672	0	0
EYS	346007	broad.mit.edu	37	6	66205196	66205196	+	Silent	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:66205196G>T	uc011dxu.1	-	4	646	c.108C>A	c.(106-108)CCC>CCA	p.P36P	EYS_uc003peq.2_Silent_p.P36P|EYS_uc003per.1_Silent_p.P36P|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	36					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						CATATGATGAGGGTTGTGGAT	0.388			NA											31	131					4.02929e-09	5.40584e-09	0.002096	1	0
COL19A1	1310	broad.mit.edu	37	6	70744142	70744142	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:70744142G>T	uc003pfc.1	+	13	1203	c.1086G>T	c.(1084-1086)TTG>TTT	p.L362F	COL19A1_uc010kam.1_Missense_Mutation_p.L258F	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	362					cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						TACAGGGTTTGAAAGGTGACT	0.378			NA											4	84					0.00909568	0.00944648	0.009096	1	0
IMPG1	3617	broad.mit.edu	37	6	76657190	76657190	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:76657190T>C	uc003pik.1	-	14	2015	c.1885A>G	c.(1885-1887)AGA>GGA	p.R629G		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	629	SEA 2.				visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				CTCCCGTTTCTGAAGTTAAGT	0.403	Pancreas(37;839 1141 2599 26037)		NA											15	40					0	0	0.004007	0	0
CNR1	1268	broad.mit.edu	37	6	88853926	88853926	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:88853926C>A	uc011dzq.1	-	2	4631	c.1068G>T	c.(1066-1068)TGG>TGT	p.W356C	CNR1_uc010kbz.2_Missense_Mutation_p.W356C|CNR1_uc011dzr.1_Missense_Mutation_p.W356C|CNR1_uc011dzs.1_Missense_Mutation_p.W356C|CNR1_uc003pmq.3_Missense_Mutation_p.W356C|CNR1_uc011dzt.1_Missense_Mutation_p.W356C|CNR1_uc010kca.2_Missense_Mutation_p.W323C	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	356	Helical; Name=6; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	GCAGAGGGCCCCAGCAGATGA	0.522			NA											9	98					1.12685e-05	1.33802e-05	0.004482	1	0
WASF1	8936	broad.mit.edu	37	6	110434599	110434599	+	Silent	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:110434599G>T	uc003ptv.1	-	5	1035	c.198C>A	c.(196-198)GTC>GTA	p.V66V	WASF1_uc003ptw.1_Silent_p.V66V|WASF1_uc003ptx.1_Silent_p.V66V|WASF1_uc003pty.1_Silent_p.V66V|WASF1_uc003ptz.1_Silent_p.V66V	NM_003931	NP_003922	Q92558	WASF1_HUMAN	Wiskott-Aldrich syndrome protein family member	66					actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		GCAATGAGTTGACTCTGAAGG	0.308			NA											9	18					0.000274275	0.000303231	0.004482	1	0
TAAR2	9287	broad.mit.edu	37	6	132938854	132938854	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:132938854A>T	uc003qdl.1	-	2	491	c.491T>A	c.(490-492)CTA>CAA	p.L164Q	TAAR2_uc010kfr.1_Missense_Mutation_p.L119Q	NM_001033080	NP_001028252	Q9P1P5	TAAR2_HUMAN	trace amine associated receptor 2 isoform 1	164	Helical; Name=4; (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00608)|GBM - Glioblastoma multiforme(226;0.0151)		ACATAGAAGTAGCAATCTTTT	0.408			NA											7	81					0	0	0.001984	0	0
VNN2	8875	broad.mit.edu	37	6	133070955	133070955	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:133070955C>T	uc003qdt.2	-	6	1261	c.1250G>A	c.(1249-1251)CGG>CAG	p.R417Q	VNN2_uc003qds.2_Missense_Mutation_p.R126Q|VNN2_uc010kgb.2_Missense_Mutation_p.R196Q|VNN2_uc003qdv.2_Missense_Mutation_p.R364Q	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	417					cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		TTCTACTGGCCGTCCACAAGT	0.408			NA											6	66					0	0	0.001984	0	0
BCLAF1	9774	broad.mit.edu	37	6	136589451	136589451	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:136589451G>A	uc003qgx.1	-	10	2499	c.2246C>T	c.(2245-2247)TCT>TTT	p.S749F	BCLAF1_uc011edb.1_Missense_Mutation_p.S77F|BCLAF1_uc003qgw.1_Missense_Mutation_p.S576F|BCLAF1_uc003qgy.1_Missense_Mutation_p.S747F|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.S747F	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	749	Poly-Ser.				induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TGAAGATCGAGAATGATCTTG	0.343	Colon(142;1534 1789 5427 7063 28491)		NA											6	64					0	0	0.001168	0	0
KIAA1244	57221	broad.mit.edu	37	6	138584589	138584589	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:138584589G>T	uc003qhu.2	+	12	1969	c.1969G>T	c.(1969-1971)GCC>TCC	p.A657S		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	657	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		GCGAACTGCCGCCCTGTCTCT	0.607			NA											10	77					1.76689e-08	2.32097e-08	0.006214	1	0
SYNE1	23345	broad.mit.edu	37	6	152757200	152757200	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:152757200C>A	uc010kiw.2	-	33	4788	c.4186G>T	c.(4186-4188)GCT>TCT	p.A1396S	SYNE1_uc003qot.3_Missense_Mutation_p.A1403S|SYNE1_uc003qou.3_Missense_Mutation_p.A1396S|SYNE1_uc010kjb.1_Missense_Mutation_p.A1379S|SYNE1_uc003qow.2_Missense_Mutation_p.A691S|SYNE1_uc003qox.1_Missense_Mutation_p.A912S	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1396	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGGTTCTCAGCCTGGACTGCA	0.388			NA								HNSCC(10;0.0054)			8	67					0.00307968	0.00327977	0.00308	1	0
CARD11	84433	broad.mit.edu	37	7	2984046	2984046	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:2984046C>T	uc003smv.2	-	5	888	c.484G>A	c.(484-486)GAG>AAG	p.E162K		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	162	Potential.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TGCTTCTTCTCATCCTCCAGC	0.577			NA	Mis		DLBCL								34	78					0	0	0.004878	0	0
SDK1	221935	broad.mit.edu	37	7	4153881	4153881	+	Silent	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:4153881G>T	uc003smx.2	+	25	3937	c.3798G>T	c.(3796-3798)GTG>GTT	p.V1266V	SDK1_uc010kso.2_Silent_p.V542V	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1266	Fibronectin type-III 6.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GGAGCGAGGTGGTGCGGGGCC	0.637			NA											5	23					0.000602214	0.000659027	0.000602	1	0
DGKB	1607	broad.mit.edu	37	7	14613946	14613946	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:14613946G>T	uc003ssz.2	-	19	1851	c.1664C>A	c.(1663-1665)ACA>AAA	p.T555K	DGKB_uc011jxt.1_Missense_Mutation_p.T536K|DGKB_uc003sta.2_Missense_Mutation_p.T555K|DGKB_uc011jxu.1_Missense_Mutation_p.T554K	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	555	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	CATGATTTCTGTGCTGTTTTC	0.348			NA											46	117					1.5731e-28	2.69572e-28	0.002852	1	0
MEOX2	4223	broad.mit.edu	37	7	15652023	15652023	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:15652023C>A	uc003stc.2	-	3	1185	c.904G>T	c.(904-906)GCG>TCG	p.A302S	MEOX2_uc011jxw.1_Missense_Mutation_p.A302S	NM_005924	NP_005915	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	302					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		CATAAGTGCGCATGCTCTGAG	0.478	Esophageal Squamous(140;197 1769 16409 18257 29929)		NA											11	76					0.000978159	0.00105815	0.000978	1	0
HDAC9	9734	broad.mit.edu	37	7	18868817	18868817	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:18868817C>T	uc003suh.2	+	17	2388	c.2347C>T	c.(2347-2349)CAC>TAC	p.H783Y	HDAC9_uc003sue.2_Missense_Mutation_p.H783Y|HDAC9_uc011jyd.1_Missense_Mutation_p.H783Y|HDAC9_uc003sui.2_Missense_Mutation_p.H786Y|HDAC9_uc003suj.2_Missense_Mutation_p.H742Y|HDAC9_uc003suk.2_Missense_Mutation_p.H31Y|HDAC9_uc003sua.1_Missense_Mutation_p.H761Y	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	783	Histone deacetylase.	By similarity.			B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	CCCTGGCCATCACGCTGAAGA	0.527			NA											15	104					0	0	0.00499	0	0
DNAH11	8701	broad.mit.edu	37	7	21856246	21856246	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:21856246C>A	uc003svc.2	+	65	10546	c.10515C>A	c.(10513-10515)CCC>CCA	p.P3505P		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3505	AAA 5 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TGATAGATCCCCAGCAACAGG	0.488			NA							Kartagener_syndrome				14	28					4.14922e-12	5.95907e-12	0.004007	1	0
CLK2P	1197	broad.mit.edu	37	7	23624887	23624887	+	Missense_Mutation	SNP	G	G	T	rs73077128	by1000genomes	TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:23624887G>T	uc003swk.2	-	1	1260	c.610C>A	c.(610-612)CGT>AGT	p.R204S		NR_002711				SubName: Full=cDNA FLJ61616, highly similar to Dual specificity protein kinase CLK2 (EC 2.7.12.1); SubName: Full=CDC-like kinase 2, isoform CRA_c; SubName: Full=Putative uncharacterized protein CLK2;												0						CAGTTCTCACGAACATAGCGT	0.498			NA											17	110					2.23348e-06	2.69879e-06	0.004007	1	0
C7orf46	340277	broad.mit.edu	37	7	23728907	23728907	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:23728907G>T	uc003swo.3	+	3	348	c.259G>T	c.(259-261)GAC>TAC	p.D87Y	C7orf46_uc003swq.3_Missense_Mutation_p.D87Y|C7orf46_uc003swr.3_Missense_Mutation_p.D29Y|C7orf46_uc003swp.3_RNA|C7orf46_uc010kup.2_RNA	NM_199136	NP_954587	A4D161	CG046_HUMAN	hypothetical protein LOC340277 isoform 1	87											0						ACATAAAACTGACTTGGAAGC	0.398			NA											24	71					8.24728e-16	1.26391e-15	0.004656	1	0
NEUROD6	63974	broad.mit.edu	37	7	31378610	31378610	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:31378610C>T	uc003tch.2	-	2	626	c.273G>A	c.(271-273)AGG>AGA	p.R91R		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	91					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						TGAACTTGACCCTTTCCAATC	0.408			NA											30	264					0	0	0.002836	0	0
CCDC129	223075	broad.mit.edu	37	7	31614183	31614183	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:31614183T>A	uc003tcj.1	+	7	1418	c.425T>A	c.(424-426)ATA>AAA	p.I142K	CCDC129_uc011kad.1_Missense_Mutation_p.I152K|CCDC129_uc003tci.1_Missense_Mutation_p.I141K|CCDC129_uc011kae.1_Missense_Mutation_p.I168K|CCDC129_uc003tck.1_Missense_Mutation_p.I50K	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	142											0						TTTTGGGAGATAGATCCAGTG	0.448			NA											27	182					0	0	0.008361	0	0
BMPER	168667	broad.mit.edu	37	7	34125418	34125418	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:34125418C>A	uc011kap.1	+	13	1573	c.1459C>A	c.(1459-1461)CCG>ACG	p.P487T		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	487	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						CATGGCTGCGCCGCATCTCAA	0.438			NA											17	62					5.3912e-06	6.45233e-06	0.006122	1	0
GPR141	353345	broad.mit.edu	37	7	37780254	37780254	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:37780254T>C	uc003tfm.1	+	1	259	c.259T>C	c.(259-261)TTC>CTC	p.F87L	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	87	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						TGGGCTGCCCTTCTGCAAATT	0.488			NA											10	91					0	0	0.008291	0	0
NPC1L1	29881	broad.mit.edu	37	7	44576029	44576029	+	Splice_Site	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:44576029T>C	uc003tlb.2	-	4	1738	c.1682_splice	c.e4-1	p.G561_splice	NPC1L1_uc003tlc.2_Splice_Site_p.G561_splice|NPC1L1_uc011kbw.1_Splice_Site_p.G561_splice|NPC1L1_uc003tld.2_Splice_Site_p.G561_splice	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1						cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	AGTCCTTTCCTGGGATAAGAA	0.607			NA											25	58					0	0	0.00632	0	0
PKD1L1	168507	broad.mit.edu	37	7	47944779	47944779	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:47944779T>A	uc003tny.1	-	11	1666	c.1666A>T	c.(1666-1668)AAA>TAA	p.K556*		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	556	Extracellular (Potential).|PKD 1.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						AGTCTTTTTTTAATGCTTCTT	0.433			NA											57	71					0	0	0.00361	0	0
IKZF1	10320	broad.mit.edu	37	7	50468265	50468266	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:50468265_50468266GG>TT	uc003tow.3	+	9	1668_1669	c.1500_1501GG>TT	c.(1498-1503)CAGGAC>CATTAC	p.500_501QD>HY	IKZF1_uc003tox.3_Missense_Mutation_p.458_459QD>HY|IKZF1_uc003toy.3_Missense_Mutation_p.458_459QD>HY|IKZF1_uc011kck.1_Missense_Mutation_p.413_414QD>HY|IKZF1_uc003toz.3_Missense_Mutation_p.470_471QD>HY|IKZF1_uc010kyx.2_Missense_Mutation_p.240_241QD>HY|IKZF1_uc003tpa.3_Missense_Mutation_p.242_243QD>HY	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	500_501	C2H2-type 6.				cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding			haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				ACCACAGCCAGGACCGGTACGA	0.629			NA	D		ALL								6	37					0	0	0.004672	0	0
COBL	23242	broad.mit.edu	37	7	51096328	51096328	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:51096328T>A	uc003tpr.3	-	10	2650	c.2465A>T	c.(2464-2466)CAC>CTC	p.H822L	COBL_uc003tps.2_Missense_Mutation_p.H879L|COBL_uc011kcl.1_Missense_Mutation_p.H822L|COBL_uc003tpp.3_Missense_Mutation_p.H608L|COBL_uc003tpq.3_Missense_Mutation_p.H763L|COBL_uc003tpo.3_Missense_Mutation_p.H364L	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	822										skin(3)|ovary(2)	5	Glioma(55;0.08)					GCCCTCATGGTGGGCAGACTT	0.642	NSCLC(189;2119 2138 12223 30818 34679)		NA											17	42					0	0	0.008871	0	0
CALN1	83698	broad.mit.edu	37	7	71252771	71252771	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:71252771C>T	uc003twa.3	-	6	1176	c.649G>A	c.(649-651)GGC>AGC	p.G217S	CALN1_uc003twb.3_Missense_Mutation_p.G259S|CALN1_uc003twc.3_Missense_Mutation_p.G217S	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	217	Extracellular (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				TACTCCATGCCGCTCCGGAGT	0.592			NA											11	31					0	0	0.000978	0	0
GTF2I	2969	broad.mit.edu	37	7	74133245	74133245	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:74133245G>A	uc003uau.2	+	12	1298	c.928G>A	c.(928-930)GAG>AAG	p.E310K	GTF2I_uc003uav.2_Intron|GTF2I_uc003uaw.2_Missense_Mutation_p.E290K|GTF2I_uc003uay.2_Intron|GTF2I_uc003uax.2_Intron|uc003uaz.2_Intron	NM_032999	NP_127492	P78347	GTF2I_HUMAN	general transcription factor IIi isoform 1	310					negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						CCCTGAAGTTGAGGTGACTAT	0.318			NA											4	26					0	0	0.009096	0	0
SRRM3	222183	broad.mit.edu	37	7	75894095	75894095	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:75894095C>T	uc010ldi.2	+	9	896	c.687C>T	c.(685-687)TCC>TCT	p.S229S	SRRM3_uc011kgi.1_5'Flank	NM_001110199	NP_001103669			serine/arginine repetitive matrix 3												0						CTCGAAGCTCCAAGTGCAAAA	0.353			NA											12	37					0	0	0.001368	0	0
CACNA2D1	781	broad.mit.edu	37	7	81635091	81635091	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:81635091G>T	uc003uhr.1	-	17	1761	c.1505C>A	c.(1504-1506)CCA>CAA	p.P502Q		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	502	Extracellular (Potential).|Cache.					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TGTAAAACGTGGTGTCAGTCT	0.348			NA											11	51					4.68919e-08	6.11704e-08	0.008291	1	0
PCLO	27445	broad.mit.edu	37	7	82544203	82544203	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:82544203C>A	uc003uhx.2	-	7	13388	c.13099G>T	c.(13099-13101)GTT>TTT	p.V4367F	PCLO_uc003uhv.2_Missense_Mutation_p.V4367F|PCLO_uc010lec.2_Missense_Mutation_p.V1332F	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4298					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGCTGGCCAACAGGACTGAGT	0.517			NA											9	48					3.09899e-07	3.91396e-07	0.004482	1	0
KIAA1324L	222223	broad.mit.edu	37	7	86521071	86521071	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:86521071A>T	uc011kha.1	-	21	3184	c.2999T>A	c.(2998-3000)CTA>CAA	p.L1000Q	KIAA1324L_uc003uif.1_Missense_Mutation_p.L760Q|KIAA1324L_uc011kgz.1_Missense_Mutation_p.L886Q|KIAA1324L_uc003uie.2_Missense_Mutation_p.L833Q	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	1000	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					TTTTCCTAGTAGTGACTGTTT	0.378			NA											10	104					0	0	0.000978	0	0
RUNDC3B	154661	broad.mit.edu	37	7	87407258	87407258	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:87407258C>T	uc003ujb.2	+	9	1405	c.994C>T	c.(994-996)CTT>TTT	p.L332F	RUNDC3B_uc011khd.1_Missense_Mutation_p.L315F|RUNDC3B_uc011khe.1_Missense_Mutation_p.L315F|RUNDC3B_uc003ujc.2_Missense_Mutation_p.L315F|RUNDC3B_uc003ujd.2_Missense_Mutation_p.L237F	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	332	Potential.									skin(1)	1	Esophageal squamous(14;0.00164)					AATTGTGGAGCTTCAAGATCA	0.353			NA											19	53					0	0	0.010504	0	0
SAMD9	54809	broad.mit.edu	37	7	92730776	92730776	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:92730776G>C	uc003umf.2	-	3	4891	c.4635C>G	c.(4633-4635)ATC>ATG	p.I1545M	SAMD9_uc003umg.2_Missense_Mutation_p.I1545M	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1545						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TTTTTTCATTGATTCCATATT	0.388			NA											19	73					0	0	0.006122	0	0
SLC25A13	10165	broad.mit.edu	37	7	95822393	95822393	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:95822393G>A	uc003uof.3	-	6	762	c.571C>T	c.(571-573)CGC>TGC	p.R191C	SLC25A13_uc003uog.3_Missense_Mutation_p.R191C|SLC25A13_uc011kik.1_Missense_Mutation_p.R83C	NM_014251	NP_055066	Q9UJS0	CMC2_HUMAN	solute carrier family 25, member 13 isoform 2	191	EF-hand 4.				ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			central_nervous_system(3)|skin(1)	4	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	ACATGGGGGCGGATGGTGACC	0.448			NA											12	64					0	0	0.000978	0	0
MUC17	140453	broad.mit.edu	37	7	100678887	100678887	+	Missense_Mutation	SNP	C	C	T	rs141608296		TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:100678887C>T	uc003uxp.1	+	3	4243	c.4190C>T	c.(4189-4191)CCG>CTG	p.P1397L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1397	Extracellular (Potential).|59 X approximate tandem repeats.|21.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GGAACCACTCCGTTAACAAGT	0.507			NA											138	373					0	0	0.00361	0	0
FBXL13	222235	broad.mit.edu	37	7	102608499	102608499	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:102608499C>T	uc003vaq.2	-	7	988	c.561G>A	c.(559-561)TTG>TTA	p.L187L	FBXL13_uc010liq.1_Silent_p.L2L|FBXL13_uc010lir.1_Silent_p.L187L|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Silent_p.L187L|FBXL13_uc003vav.2_RNA	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	187	F-box.										0						GTTGTGTCATCAACATCCAGG	0.343			NA											9	67					0	0	0.004482	0	0
CDHR3	222256	broad.mit.edu	37	7	105641938	105641938	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:105641938A>T	uc003vdl.3	+	7	852	c.744A>T	c.(742-744)GAA>GAT	p.E248D	CDHR3_uc003vdk.2_Intron|CDHR3_uc011kls.1_RNA|CDHR3_uc003vdm.3_Missense_Mutation_p.E235D|CDHR3_uc011klt.1_Missense_Mutation_p.E160D|CDHR3_uc003vdn.2_5'UTR	NM_152750	NP_689963	Q6ZTQ4	CDHR3_HUMAN	hypothetical protein LOC222256 precursor	248	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						TCCTGGAGGAACTGAGTCCAG	0.517			NA											36	104					0	0	0.002836	0	0
PIK3CG	5294	broad.mit.edu	37	7	106509209	106509209	+	Silent	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:106509209C>G	uc003vdv.3	+	2	1288	c.1203C>G	c.(1201-1203)CCC>CCG	p.P401P	PIK3CG_uc003vdu.2_Silent_p.P401P|PIK3CG_uc003vdw.2_Silent_p.P401P	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	401					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						GAACCAGCCCCAAACCCTTCA	0.502			NA											8	75					0	0	0.004482	0	0
LAMB1	3912	broad.mit.edu	37	7	107575875	107575875	+	Silent	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:107575875T>C	uc003vew.2	-	27	4508	c.4173A>G	c.(4171-4173)TCA>TCG	p.S1391S	LAMB1_uc003vev.2_Silent_p.S1415S	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1391	Domain II.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGGCAGCGGCTGAAAGGTCTA	0.418			NA											12	215					0	0	0.001368	0	0
C7orf66	154907	broad.mit.edu	37	7	108524073	108524073	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:108524073C>A	uc003vfo.2	-	2	387	c.339G>T	c.(337-339)ATG>ATT	p.M113I		NM_001024607	NP_001019778	A4D0T2	CG066_HUMAN	hypothetical protein LOC154907	113						integral to membrane				ovary(2)	2						CTTAATTTCCCATTTCCTTTG	0.323			NA											22	55					3.5997e-14	5.3746e-14	0.002299	1	0
CTTNBP2	83992	broad.mit.edu	37	7	117375441	117375441	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:117375441C>T	uc003vjf.2	-	15	3662	c.3570G>A	c.(3568-3570)AAG>AAA	p.K1190K		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1190										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TGATTTTCTTCTTACTGGGAG	0.313			NA											8	161					0	0	0.00308	0	0
Unknown	0	broad.mit.edu	37	7	124116560	124116560	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:124116560G>T	uc011kod.1	+	1	136	c.136G>T	c.(136-138)GGA>TGA	p.G46*		NM_001085395	NP_001078864			RecName: Full=Putative RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like protein 2;          Short=CTD phosphatase SSU72-like protein 2;          EC=3.1.3.16;												NA						GAGGCTACCAGGACGAAGACC	0.468			NA											5	141					3.59834e-05	4.19342e-05	0.001168	1	0
GPR37	2861	broad.mit.edu	37	7	124404249	124404249	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:124404249G>C	uc003vli.2	-	1	1433	c.782C>G	c.(781-783)GCC>GGC	p.A261G		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	261	Extracellular (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						GACCGCGTAGGCTCCATAGGA	0.607			NA											9	47					0	0	0.008291	0	0
CCDC136	64753	broad.mit.edu	37	7	128454947	128454947	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:128454947T>A	uc003vnv.1	+	15	3386	c.3019T>A	c.(3019-3021)TCT>ACT	p.S1007T	CCDC136_uc003vnu.1_Intron|CCDC136_uc003vnw.1_Intron|CCDC136_uc003vnx.1_Missense_Mutation_p.S823T|CCDC136_uc010llq.1_Missense_Mutation_p.S376T|CCDC136_uc003vny.1_Intron	NM_022742	NP_073579	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	1007						integral to membrane	protein binding			ovary(2)	2						CTCGGATACTTCTGAGAGCGA	0.468			NA											3	14					0	0	0.004672	0	0
FLNC	2318	broad.mit.edu	37	7	128480720	128480720	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:128480720C>A	uc003vnz.3	+	10	1877	c.1668C>A	c.(1666-1668)ATC>ATA	p.I556I	FLNC_uc003voa.3_Silent_p.I556I	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	556	Filamin 3.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GCTACGCCATCCCTCGCAGGT	0.637			NA											23	90					2.27731e-05	2.67043e-05	0.001882	1	0
EXOC4	60412	broad.mit.edu	37	7	132937864	132937864	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:132937864G>C	uc003vrk.2	+	1	42	c.7G>C	c.(7-9)GCA>CCA	p.A3P	EXOC4_uc011kpo.1_5'Flank|EXOC4_uc003vri.2_Missense_Mutation_p.A3P|EXOC4_uc003vrj.2_Missense_Mutation_p.A3P	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	3					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				CAAGATGGCGGCAGAAGCAGC	0.577			NA											12	73					0	0	0.00245	0	0
DGKI	9162	broad.mit.edu	37	7	137154319	137154319	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:137154319G>C	uc003vtt.2	-	25	2475	c.2474C>G	c.(2473-2475)TCT>TGT	p.S825C	DGKI_uc003vtu.2_Missense_Mutation_p.S525C	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	825					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						CCACCGAGGAGAGAGCCTCTG	0.527			NA											10	47					0	0	0.000978	0	0
TAS2R4	50832	broad.mit.edu	37	7	141478932	141478932	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:141478932C>T	uc003vwq.1	+	1	644	c.644C>T	c.(643-645)ACT>ATT	p.T215I		NM_016944	NP_058640	Q9NYW5	TA2R4_HUMAN	taste receptor T2R4	215	Cytoplasmic (Potential).				sensory perception of taste	cilium membrane	taste receptor activity				0	Melanoma(164;0.0171)			BRCA - Breast invasive adenocarcinoma(188;0.196)		AAAAATGCCACTGGTTTCTGG	0.443			NA											4	98					0	0	0.009096	0	0
MGAM	8972	broad.mit.edu	37	7	141794611	141794611	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:141794611A>T	uc003vwy.2	+	40	4772	c.4718A>T	c.(4717-4719)CAG>CTG	p.Q1573L		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1573	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CGCTGGATGCAGCTGGGGGCC	0.498			NA											5	35					0	0	0.001168	0	0
EPHB6	2051	broad.mit.edu	37	7	142561848	142561848	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:142561848G>T	uc011kst.1	+	7	1077	c.290G>T	c.(289-291)CGG>CTG	p.R97L	EPHB6_uc011ksu.1_Missense_Mutation_p.R97L|EPHB6_uc003wbs.2_5'UTR|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_5'UTR	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	97	Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					TTTGTGGAGCGGCGCGGGGCC	0.657			NA											25	168					6.36457e-07	7.90591e-07	0.003954	1	0
TRPV6	55503	broad.mit.edu	37	7	142573593	142573593	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:142573593G>C	uc003wbx.1	-	7	1043	c.827C>G	c.(826-828)ACT>AGT	p.T276S	TRPV6_uc003wbw.1_Missense_Mutation_p.T62S|TRPV6_uc010lou.1_Missense_Mutation_p.T147S	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	276	Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					GTCATAGAGAGTCGAGGTCAG	0.527			NA											22	101					0	0	0.00333	0	0
CLCN1	1180	broad.mit.edu	37	7	143028687	143028687	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:143028687C>A	uc003wcr.1	+	10	1195	c.1108C>A	c.(1108-1110)CGC>AGC	p.R370S	CLCN1_uc011ktc.1_Missense_Mutation_p.R32S	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	370	Helical; (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					GTATCTGCATCGCCAAGTCAT	0.478			NA											7	69					0.000274275	0.000303231	0.004482	1	0
EPHA1	2041	broad.mit.edu	37	7	143094673	143094673	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:143094673T>G	uc003wcz.2	-	9	1780	c.1693A>C	c.(1693-1695)ATT>CTT	p.I565L		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	565	Helical; (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				AAAACGAGAATCCCAAGCAGC	0.622			NA											3	51					0	0	0.004672	0	0
EPHA1	2041	broad.mit.edu	37	7	143098433	143098433	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:143098433C>A	uc003wcz.2	-	3	503	c.416G>T	c.(415-417)CGG>CTG	p.R139L		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	139	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				GAACAAGGGCCGTCGGAGCTG	0.587			NA											11	94					1.58986e-06	1.92726e-06	0.008291	1	0
CNTNAP2	26047	broad.mit.edu	37	7	148112510	148112510	+	Silent	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:148112510C>G	uc003weu.1	+	24	4314	c.3798C>G	c.(3796-3798)GGC>GGG	p.G1266G	CNTNAP2_uc003wev.1_Silent_p.G43G	NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	1266	Helical; (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CTCCGTCAGGCGTCATTGCTG	0.557			NA								HNSCC(39;0.1)			6	47					0	0	0.001984	0	0
GIMAP6	474344	broad.mit.edu	37	7	150324822	150324823	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:150324822_150324823CC>AA	uc003whn.2	-	3	1287_1288	c.863_864GG>TT	c.(862-864)GGG>GTT	p.G288V	GIMAP6_uc003whm.2_Missense_Mutation_p.G208V	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	288							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGTCAGCCTTCCCCAGCAGGCA	0.584			NA											16	77					0	0	0.004672	0	0
ABCB8	11194	broad.mit.edu	37	7	150730964	150730965	+	Missense_Mutation	DNP	TT	TT	CC			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	TT	TT	-	-	TT	TT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:150730964_150730965TT>CC	uc003wil.3	+	3	512_513	c.419_420TT>CC	c.(418-420)TTT>TCC	p.F140S	ABCB8_uc003wii.2_Missense_Mutation_p.F160S|ABCB8_uc003wij.3_Missense_Mutation_p.F123S|ABCB8_uc010lpw.1_Intron|ABCB8_uc010lpx.2_Missense_Mutation_p.F123S|ABCB8_uc011kvd.1_Intron|ABCB8_uc003wim.3_Intron|ABCB8_uc003wik.3_Missense_Mutation_p.F123S	NM_007188	NP_009119	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B, member 8	140						ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTCTGGCAGTTTCTGCACCCCC	0.624			NA											9	50					0	0	0.004672	0	0
DEFA4	1669	broad.mit.edu	37	8	6793589	6793589	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:6793589G>C	uc003wqu.1	-	3	298	c.247C>G	c.(247-249)CTC>GTC	p.L83V		NM_001925	NP_001916	P12838	DEF4_HUMAN	defensin, alpha 4 preproprotein	83					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				large_intestine(1)	1				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		CCACCAATGAGGCAGTTCCCA	0.512			NA											9	50					0	0	0.000978	0	0
C8orf74	203076	broad.mit.edu	37	8	10557970	10557970	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:10557970G>T	uc003wtd.1	+	4	903	c.874G>T	c.(874-876)GCA>TCA	p.A292S	C8orf74_uc003wte.1_RNA	NM_001040032	NP_001035121	Q6P047	CH074_HUMAN	hypothetical protein LOC203076	292											0				COAD - Colon adenocarcinoma(149;0.0811)		GAAAGCGAAGGCAAGGAAGTA	0.622			NA											6	7					5.9392e-07	7.40191e-07	0.001168	1	0
DLC1	10395	broad.mit.edu	37	8	12952352	12952352	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:12952352C>T	uc003wwm.2	-	12	3886	c.3442G>A	c.(3442-3444)GAC>AAC	p.D1148N	DLC1_uc003wwk.1_Missense_Mutation_p.D711N|DLC1_uc003wwl.1_Missense_Mutation_p.D745N|DLC1_uc011kxx.1_Missense_Mutation_p.D637N	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1148	Rho-GAP.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TTCAGCATGTCTGCCACGTCA	0.473			NA											5	34					0	0	0.001168	0	0
BMP1	649	broad.mit.edu	37	8	22023023	22023023	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:22023023G>C	uc003xbg.2	+	1	349	c.105G>C	c.(103-105)GAG>GAC	p.E35D	BMP1_uc011kzb.1_RNA|BMP1_uc003xba.2_Missense_Mutation_p.E35D|BMP1_uc003xbb.2_Missense_Mutation_p.E35D|BMP1_uc003xbe.2_RNA|BMP1_uc003xbc.2_5'UTR|BMP1_uc003xbd.2_RNA|BMP1_uc003xbf.2_5'UTR|BMP1_uc011kzc.1_5'UTR|BMP1_uc003xbh.2_RNA|BMP1_uc003xbi.2_RNA	NM_006129	NP_006120	P13497	BMP1_HUMAN	bone morphogenetic protein 1 isoform 3	35					cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|breast(1)	3				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		TGGCGGAGGAGGACGACTCGG	0.532			NA											6	9					0	0	0.001168	0	0
ZMAT4	79698	broad.mit.edu	37	8	40554910	40554910	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:40554910G>T	uc003xnr.2	-	4	349	c.203C>A	c.(202-204)GCC>GAC	p.A68D	ZMAT4_uc003xns.2_Missense_Mutation_p.A68D	NM_024645	NP_078921	Q9H898	ZMAT4_HUMAN	zinc finger, matrin type 4 isoform a	68						nucleus	DNA binding|zinc ion binding			pancreas(1)|central_nervous_system(1)|skin(1)	3	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			CACCATGTCGGCATCACTTCC	0.478			NA											16	26					6.31663e-08	8.21161e-08	0.003163	1	0
ANK1	286	broad.mit.edu	37	8	41530184	41530184	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:41530184G>T	uc003xok.2	-	38	4868	c.4784C>A	c.(4783-4785)GCC>GAC	p.A1595D	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Intron|ANK1_uc003xoi.2_Missense_Mutation_p.A1595D|ANK1_uc003xoj.2_Missense_Mutation_p.A1595D|ANK1_uc003xol.2_Intron|ANK1_uc003xom.2_Missense_Mutation_p.A1636D	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1595	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GTGACCTGTGGCATCAGAGTC	0.597			NA											78	83					1.25089e-41	2.18833e-41	0.00361	1	0
TRIM55	84675	broad.mit.edu	37	8	67062624	67062624	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:67062624G>A	uc003xvv.2	+	7	1134	c.908G>A	c.(907-909)GGC>GAC	p.G303D	TRIM55_uc003xvu.2_Missense_Mutation_p.G303D|TRIM55_uc003xvw.2_Missense_Mutation_p.G303D|TRIM55_uc003xvx.2_Intron	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	303	COS.					cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			ATAGAACATGGCTATGAGAAC	0.368			NA											7	102					0	0	0.001984	0	0
CRH	1392	broad.mit.edu	37	8	67089250	67089250	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:67089250C>G	uc003xvy.1	-	2	648	c.463G>C	c.(463-465)GAG>CAG	p.E155Q		NM_000756	NP_000747	P06850	CRF_HUMAN	corticotropin releasing hormone precursor	155					female pregnancy|negative regulation of circadian sleep/wake cycle, REM sleep|parturition|positive regulation of circadian sleep/wake cycle, wakefulness|positive regulation of cortisol secretion|signal transduction|synaptic transmission	extracellular region|soluble fraction	neuropeptide hormone activity				0		all_cancers(86;2.58e-06)|all_epithelial(80;6.27e-09)|all_lung(136;0.000414)|Lung NSC(129;0.0011)	Epithelial(68;0.0136)|all cancers(69;0.0507)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)		Corticotropin(DB01285)	GGAGGCTCCTCGGACCGCCTT	0.672			NA									OREG0018805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	27					0	0	0.006214	0	0
ADHFE1	137872	broad.mit.edu	37	8	67355077	67355077	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:67355077G>A	uc003xwb.3	+	3	176	c.142G>A	c.(142-144)GAG>AAG	p.E48K	ADHFE1_uc003xwd.3_RNA|ADHFE1_uc003xwc.3_Intron|ADHFE1_uc003xwe.3_Intron|ADHFE1_uc003xwf.3_RNA|ADHFE1_uc011les.1_Intron|ADHFE1_uc011leq.1_RNA|ADHFE1_uc011ler.1_RNA	NM_144650	NP_653251	Q8IWW8	HOT_HUMAN	alcohol dehydrogenase, iron containing, 1	48					2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			TTATGCCTTTGAGGTATATTC	0.274			NA											18	65					0	0	0.006122	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68200218	68200218	+	Silent	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:68200218T>C	uc003xxo.1	-	7	1389	c.999A>G	c.(997-999)GTA>GTG	p.V333V		NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	333					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			CCATTTCTTCTACAATGTTCT	0.323			NA											30	111					0	0	0.002445	0	0
NCOA2	10499	broad.mit.edu	37	8	71078980	71078980	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:71078980C>A	uc003xyn.1	-	7	713	c.551G>T	c.(550-552)GGA>GTA	p.G184V		NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	184					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			AGACCAAGATCCCCCATTTAC	0.408			NA	T	RUNXBP2	AML								48	187					2.52991e-16	3.91694e-16	0.00361	1	0
JPH1	56704	broad.mit.edu	37	8	75227264	75227264	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:75227264C>A	uc003yae.2	-	2	1011	c.971G>T	c.(970-972)GGC>GTC	p.G324V	JPH1_uc003yaf.2_Missense_Mutation_p.G324V|JPH1_uc003yag.1_Missense_Mutation_p.G188V	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	324	Cytoplasmic (Potential).|MORN 7.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			TTCTTTGGAGCCGTCAGGAAA	0.463			NA											50	142					1.19451e-25	2.01041e-25	0.00361	1	0
ZFHX4	79776	broad.mit.edu	37	8	77690524	77690524	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:77690524C>A	uc003yav.2	+	4	3483	c.3096C>A	c.(3094-3096)GTC>GTA	p.V1032V	ZFHX4_uc003yau.1_Silent_p.V1058V|ZFHX4_uc003yaw.1_Silent_p.V1032V	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1032	C2H2-type 7.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCACCAAGGTCAAGTTGAATC	0.542			NA								HNSCC(33;0.089)			40	119					3.3946e-10	4.67921e-10	0.005524	1	0
ZFHX4	79776	broad.mit.edu	37	8	77768313	77768313	+	Silent	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:77768313G>A	uc003yav.2	+	10	9408	c.9021G>A	c.(9019-9021)CCG>CCA	p.P3007P	ZFHX4_uc003yau.1_Silent_p.P3052P|ZFHX4_uc003yaw.1_Silent_p.P3007P	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3007						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACTTGGCTCCGACCACGGTTC	0.507			NA								HNSCC(33;0.089)			10	109					0	0	0.008291	0	0
STMN2	11075	broad.mit.edu	37	8	80577088	80577088	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:80577088C>T	uc003ybj.2	+	5	570	c.519C>T	c.(517-519)CTC>CTT	p.L173L	STMN2_uc010lzp.2_RNA|STMN2_uc011lfn.1_Intron|STMN2_uc003ybk.2_RNA	NM_007029	NP_008960	Q93045	STMN2_HUMAN	superiorcervical ganglia, neural specific 10	173	Potential.				intracellular signal transduction|negative regulation of microtubule depolymerization|negative regulation of microtubule polymerization|negative regulation of neuron projection development|neuron differentiation|positive regulation of microtubule depolymerization|positive regulation of neuron projection development	axon|growth cone|membrane|membrane fraction|perinuclear region of cytoplasm|soluble fraction	protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(9;8.34e-05)		Epithelial(68;0.0229)|all cancers(69;0.0874)			ACAAGGAACTCCAGGTTGAAC	0.498			NA											10	34					0	0	0.006214	0	0
RBM12B	389677	broad.mit.edu	37	8	94746661	94746661	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:94746661T>A	uc003yfz.2	-	3	2171	c.1978A>T	c.(1978-1980)AGG>TGG	p.R660W		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	660							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GGGAGCCACCTTAAGTCCTCC	0.637			NA											57	132					0	0	0.00361	0	0
DPY19L4	286148	broad.mit.edu	37	8	95802050	95802050	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:95802050C>T	uc003ygx.2	+	19	2208	c.2084C>T	c.(2083-2085)TCT>TTT	p.S695F		NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	695						integral to membrane				ovary(2)	2	Breast(36;3.85e-06)					ATTAACTATTCTCCATATGTG	0.313			NA											26	113					0	0	0.004656	0	0
PABPC1	26986	broad.mit.edu	37	8	101718960	101718960	+	Silent	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:101718960G>A	uc003yjs.1	-	11	2025	c.1521C>T	c.(1519-1521)ACC>ACT	p.T507T	PABPC1_uc011lhc.1_Silent_p.T475T|PABPC1_uc011lhd.1_Silent_p.T462T|PABPC1_uc003yjt.1_Silent_p.T504T|PABPC1_uc003yju.2_Intron	NM_002568	NP_002559	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	507					mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity				0	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			ACTGTGGAACGGTGCGGACAG	0.438			NA											18	69					0	0	0.006122	0	0
PABPC1	26986	broad.mit.edu	37	8	101719186	101719186	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:101719186G>A	uc003yjs.1	-	10	1880	c.1376C>T	c.(1375-1377)CCT>CTT	p.P459L	PABPC1_uc011lhc.1_Missense_Mutation_p.P427L|PABPC1_uc011lhd.1_Missense_Mutation_p.P414L|PABPC1_uc003yjt.1_Missense_Mutation_p.P456L|PABPC1_uc003yju.2_Intron	NM_002568	NP_002559	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	459					mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity				0	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			TGGTGGTCTAGGAGCAGCTGG	0.413			NA											9	59					0	0	0.006214	0	0
DCAF13	25879	broad.mit.edu	37	8	104427550	104427550	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:104427550G>T	uc003yln.2	+	1	609	c.332G>T	c.(331-333)CGC>CTC	p.R111L	SLC25A32_uc003yll.2_5'Flank|SLC25A32_uc011lhr.1_5'Flank|DCAF13_uc003ylm.1_5'UTR|DCAF13_uc003ylo.2_5'UTR	NM_015420	NP_056235	Q9NV06	DCA13_HUMAN	WD repeats and SOF1 domain containing	Error:Variant_position_missing_in_Q9NV06_after_alignment					rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				breast(1)	1						CCAGCAGGCCGCCGCTCCGCG	0.637			NA											22	53					1.50039e-11	2.13855e-11	0.001882	1	0
ZFPM2	23414	broad.mit.edu	37	8	106456569	106456569	+	Silent	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:106456569G>T	uc003ymd.2	+	3	284	c.261G>T	c.(259-261)CCG>CCT	p.P87P		NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	87					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CAGAGAAACCGGGGCAACCTG	0.443			NA											7	20					0.000157383	0.000177645	0.00308	1	0
TMEM74	157753	broad.mit.edu	37	8	109796746	109796746	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:109796746G>C	uc003ymy.1	-	2	687	c.582C>G	c.(580-582)ATC>ATG	p.I194M	TMEM74_uc003ymx.2_Intron	NM_153015	NP_694560	Q96NL1	TMM74_HUMAN	transmembrane protein 74	194	Helical; (Potential).				autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)			CGATGTAAGAGATGATCACGA	0.552			NA											24	60					0	0	0.00278	0	0
CSMD3	114788	broad.mit.edu	37	8	113293524	113293524	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:113293524A>T	uc003ynu.2	-	59	9546	c.9387T>A	c.(9385-9387)GAT>GAA	p.D3129E	CSMD3_uc003yns.2_Missense_Mutation_p.D2331E|CSMD3_uc003ynt.2_Missense_Mutation_p.D3089E|CSMD3_uc011lhx.1_Missense_Mutation_p.D2960E	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3129	Extracellular (Potential).|Sushi 23.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATGTTGTGCCATCAATTCGGA	0.413			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	54					0	0	0.000978	0	0
CSMD3	114788	broad.mit.edu	37	8	113650925	113650925	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:113650925C>A	uc003ynu.2	-	21	3685	c.3526G>T	c.(3526-3528)GAA>TAA	p.E1176*	CSMD3_uc003yns.2_Nonsense_Mutation_p.E448*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.E1136*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.E1072*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1176	Extracellular (Potential).|CUB 6.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATTTTCTCACCAGAGAATGTT	0.308			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			9	32					0.000274275	0.000303231	0.004482	1	0
TRPS1	7227	broad.mit.edu	37	8	116616407	116616407	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:116616407G>T	uc003ynz.2	-	3	2209	c.1750C>A	c.(1750-1752)CCG>ACG	p.P584T	TRPS1_uc011lhy.1_Missense_Mutation_p.P588T|TRPS1_uc003yny.2_Missense_Mutation_p.P597T|TRPS1_uc010mcy.2_Missense_Mutation_p.P584T	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	584					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CAAGCAAACGGATAAGTAATT	0.468			NA							Langer-Giedion_syndrome				7	44					2.7689e-08	3.63087e-08	0.001984	1	0
NOV	4856	broad.mit.edu	37	8	120435290	120435290	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:120435290G>T	uc003yoq.2	+	5	1213	c.992G>T	c.(991-993)TGC>TTC	p.C331F		NM_002514	NP_002505	P48745	NOV_HUMAN	nephroblastoma overexpressed precursor	331	CTCK.				regulation of cell growth		growth factor activity|insulin-like growth factor binding			ovary(2)|skin(2)|kidney(1)	5	all_cancers(13;3.84e-26)|Lung NSC(37;1.19e-08)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000507)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATTGGGACCTGCACCTGTCAC	0.527			NA											18	222					2.4624e-09	3.30953e-09	0.008871	1	0
ENPP2	5168	broad.mit.edu	37	8	120629471	120629471	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:120629471G>A	uc003yot.1	-	7	676	c.590C>T	c.(589-591)ACA>ATA	p.T197I	ENPP2_uc003yos.1_Missense_Mutation_p.T197I|ENPP2_uc010mdd.1_Missense_Mutation_p.T197I	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	197					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			GGGAGAGTGTGTGCCACAAGA	0.378	Melanoma(20;305 879 2501 4818 31020)		NA											16	66					0	0	0.007413	0	0
ZNF572	137209	broad.mit.edu	37	8	125988734	125988735	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:125988734_125988735GG>AT	uc003yrr.2	+	3	379_380	c.224_225GG>AT	c.(223-225)TGG>TAT	p.W75Y		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	75					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CCACTGACATGGGTTCAAGATG	0.386			NA								HNSCC(60;0.17)			22	70					0	0	0.004672	0	0
KIAA0196	9897	broad.mit.edu	37	8	126071510	126071510	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:126071510C>A	uc003yrt.2	-	14	2047	c.1718G>T	c.(1717-1719)AGG>ATG	p.R573M	KIAA0196_uc011lir.1_Missense_Mutation_p.R425M|KIAA0196_uc003yru.1_Missense_Mutation_p.R147M	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	573					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			TGGATTTACCCTTATGCTTTC	0.408			NA											12	71					1.5842e-08	2.09192e-08	0.001855	1	0
TG	7038	broad.mit.edu	37	8	133894758	133894759	+	Missense_Mutation	DNP	GG	GG	TC			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:133894758_133894759GG>TC	uc003ytw.2	+	7	831_832	c.790_791GG>TC	c.(790-792)GGC>TCC	p.G264S		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	264	Thyroglobulin type-1 3.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CATTTTTGCTGGCCTGGACCTT	0.475			NA											56	217					0	0	0.004672	0	0
TG	7038	broad.mit.edu	37	8	133906086	133906086	+	Silent	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:133906086C>G	uc003ytw.2	+	11	2954	c.2913C>G	c.(2911-2913)GGC>GGG	p.G971G		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	971	Thyroglobulin type-1 8.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGGACCTCGGCCTTCCTCCGC	0.592			NA											30	76					0	0	0.009535	0	0
FAM135B	51059	broad.mit.edu	37	8	139155262	139155262	+	Silent	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:139155262G>T	uc003yuy.2	-	16	3802	c.3631C>A	c.(3631-3633)CGA>AGA	p.R1211R	FAM135B_uc003yux.2_Silent_p.R1112R|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Silent_p.R773R|FAM135B_uc003yvb.2_3'UTR	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1211										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TACCTAATTCGGGATATGGAG	0.398			NA								HNSCC(54;0.14)			12	53					2.27111e-07	2.87801e-07	0.001368	1	0
COL22A1	169044	broad.mit.edu	37	8	139601675	139601675	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:139601675C>G	uc003yvd.2	-	65	5149	c.4702G>C	c.(4702-4704)GGG>CGG	p.G1568R	COL22A1_uc011ljo.1_Missense_Mutation_p.G848R	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1568	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CCAGGTTCCCCGGGTTGACCT	0.577			NA								HNSCC(7;0.00092)			8	12					0	0	0.00308	0	0
CYP11B1	1584	broad.mit.edu	37	8	143956473	143956473	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:143956473C>G	uc003yxi.2	-	8	1305	c.1298G>C	c.(1297-1299)GGC>GCC	p.G433A	CYP11B1_uc010mex.2_Missense_Mutation_p.G132A|CYP11B1_uc003yxh.2_Intron|CYP11B1_uc003yxj.2_Intron|CYP11B1_uc010mey.2_Missense_Mutation_p.G504A	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	433					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	CCTGCCGGAGCCCCTGATGTC	0.632			NA							Familial_Hyperaldosteronism_type_I				27	90					0	0	0.007291	0	0
CYP11B1	1584	broad.mit.edu	37	8	143958141	143958141	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:143958141C>T	uc003yxi.2	-	4	763	c.756G>A	c.(754-756)GTG>GTA	p.V252V	CYP11B1_uc010mex.2_5'Flank|CYP11B1_uc003yxh.2_5'Flank|CYP11B1_uc003yxj.2_Silent_p.V252V|CYP11B1_uc010mey.2_Silent_p.V323V	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	252					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	GCTCCTTCCACACCTTGGGGC	0.602			NA							Familial_Hyperaldosteronism_type_I				4	38					0	0	0.009096	0	0
PTPRD	5789	broad.mit.edu	37	9	8340382	8340382	+	Silent	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:8340382G>T	uc003zkk.2	-	41	5925	c.5214C>A	c.(5212-5214)ACC>ACA	p.T1738T	PTPRD_uc003zkp.2_Silent_p.T1332T|PTPRD_uc003zkq.2_Silent_p.T1331T|PTPRD_uc003zkr.2_Silent_p.T1322T|PTPRD_uc003zks.2_Silent_p.T1331T|PTPRD_uc003zkl.2_Silent_p.T1729T|PTPRD_uc003zkm.2_Silent_p.T1725T|PTPRD_uc003zkn.2_Silent_p.T1327T|PTPRD_uc003zko.2_Silent_p.T1328T	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1738	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TCACAACTATGGTGGAATTGT	0.498			NA								TSP Lung(15;0.13)			7	36					0.00198382	0.0021157	0.001984	1	0
PTPRD	5789	broad.mit.edu	37	9	8518250	8518250	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:8518250C>A	uc003zkk.2	-	20	1852	c.1141G>T	c.(1141-1143)GCT>TCT	p.A381S	PTPRD_uc003zkp.2_Missense_Mutation_p.A381S|PTPRD_uc003zkq.2_Missense_Mutation_p.A381S|PTPRD_uc003zkr.2_Missense_Mutation_p.A375S|PTPRD_uc003zks.2_Missense_Mutation_p.A371S|PTPRD_uc003zkl.2_Missense_Mutation_p.A381S|PTPRD_uc003zkm.2_Missense_Mutation_p.A368S|PTPRD_uc003zkn.2_Missense_Mutation_p.A381S|PTPRD_uc003zko.2_Missense_Mutation_p.A378S	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	381	Fibronectin type-III 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTTAGTCCAGCGACACTGTAG	0.468			NA								TSP Lung(15;0.13)			27	88					6.32553e-13	9.24312e-13	0.004656	1	0
CER1	9350	broad.mit.edu	37	9	14722195	14722195	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:14722195C>A	uc003zlj.2	-	1	521	c.476G>T	c.(475-477)TGG>TTG	p.W159L		NM_005454	NP_005445	O95813	CER1_HUMAN	cerberus 1 precursor	159					BMP signaling pathway	extracellular space	cytokine activity				0				GBM - Glioblastoma multiforme(50;3.16e-06)		GCAGGTCTCCCAATGTACTTC	0.527			NA											15	46					0.000422831	0.000466104	0.004007	1	0
BNC2	54796	broad.mit.edu	37	9	16419146	16419146	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:16419146C>A	uc003zml.2	-	7	3281	c.3141G>T	c.(3139-3141)AAG>AAT	p.K1047N	BNC2_uc011lmw.1_Missense_Mutation_p.K952N|BNC2_uc003zmm.2_3'UTR|BNC2_uc011lmv.1_3'UTR|BNC2_uc003zmj.2_3'UTR|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.K834N	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	1047	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		TCAGGGTCCCCTTGTTGCTGT	0.468			NA											15	45					6.31663e-08	8.21161e-08	0.003163	1	0
IFNB1	3456	broad.mit.edu	37	9	21077402	21077402	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:21077402G>T	uc003zok.2	-	1	542	c.467C>A	c.(466-468)GCC>GAC	p.A156D		NM_002176	NP_002167	P01574	IFNB_HUMAN	interferon, beta 1, fibroblast precursor	156					activation of caspase activity|B cell proliferation|blood coagulation|cellular response to exogenous dsRNA|defense response to virus|induction of apoptosis|natural killer cell activation|negative regulation of cell proliferation|negative regulation of T cell differentiation|negative regulation of T-helper 2 cell cytokine production|negative regulation of viral genome replication|negative regulation of viral transcription|negative regulation of virion penetration into host cell|positive regulation of innate immune response|positive regulation of transcription from RNA polymerase II promoter|regulation of MHC class I biosynthetic process|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding|transcription corepressor activity			ovary(1)|breast(1)|kidney(1)	3				GBM - Glioblastoma multiforme(5;7.45e-142)|Lung(24;2.42e-17)|LUSC - Lung squamous cell carcinoma(38;7.17e-11)	Interferon beta-1a(DB00060)|Interferon beta-1b(DB00068)	GTACTCCTTGGCCTTCAGGTA	0.433			NA											40	134					2.59497e-14	3.88988e-14	0.007835	1	0
CDKN2A	1029	broad.mit.edu	37	9	21971108	21971108	+	Missense_Mutation	SNP	C	C	T	rs11552822		TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:21971108C>T	uc003zpk.2	-	2	462	c.250G>A	c.(250-252)GAC>AAC	p.D84N	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.R139Q	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	84	ANK 3.		D -> E (in a bladder tumor).|D -> N (in an esophagus, a head and neck and a lung tumor).|D -> H (in non-small cell lung carcinoma).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.D84Y(9)|p.D84V(4)|p.D84N(3)|p.D84G(2)|p.D84fs*63(2)|p.D84H(2)|p.H83fs*2(2)|p.D84_F90del(1)|p.D84D(1)|p.V82_E88del(1)|p.V82_G89>G(1)|p.D84fs*0(1)|p.E61_L94del(1)|p.D84fs*36(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.P81_A85del(1)|p.R80fs*34(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CGGGCAGCGTCGTGCACGGGT	0.741		D84Y(LK2_LUNG)|D84Y(DU145_PROSTATE)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			5	16					0	0	0.001168	0	0
C9orf72	203228	broad.mit.edu	37	9	27562475	27562475	+	Splice_Site	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:27562475C>A	uc003zqq.2	-	4	602	c.505_splice	c.e4-1	p.G169_splice	C9orf72_uc003zqr.1_Splice_Site_p.G169_splice	NM_018325	NP_060795	Q96LT7	CI072_HUMAN	hypothetical protein LOC203228 isoform a											ovary(3)|central_nervous_system(1)	4		all_neural(11;7.57e-10)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.00016)		TACTCTGACCCTGCACAATAA	0.333			NA											9	33					0.000442599	0.000486472	0.006214	1	0
TAF1L	138474	broad.mit.edu	37	9	32632712	32632712	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:32632712C>A	uc003zrg.1	-	1	2956	c.2866G>T	c.(2866-2868)GCC>TCC	p.A956S	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	956					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GCAATGAAGGCCCTTGTGGTG	0.478			NA											18	132					4.75885e-15	7.21966e-15	0.00499	1	0
VCP	7415	broad.mit.edu	37	9	35059077	35059077	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:35059077G>A	uc003zvy.2	-	15	2533	c.2144C>T	c.(2143-2145)ACA>ATA	p.T715I	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Missense_Mutation_p.T384I|VCP_uc010mki.1_Missense_Mutation_p.T670I	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	715					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TGATGGGTTTGTCTGCCTCTC	0.547			NA											13	99					0	0	0.00245	0	0
FAM75A6	389730	broad.mit.edu	37	9	43626729	43626729	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:43626729T>A	uc011lrb.1	-	4	1987	c.1958A>T	c.(1957-1959)CAG>CTG	p.Q653L		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	653						integral to membrane					0						CTTCACCTTCTGTGCCTCCTT	0.557			NA											29	77					0	0	0.003271	0	0
Unknown	0	broad.mit.edu	37	9	69440145	69440145	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:69440145G>T	uc010mnx.1	+	3	398	c.229G>T	c.(229-231)GAA>TAA	p.E77*		NM_001098806	NP_001092276			coiled-coil domain containing 29												NA						ACAGCAATGTGAAAAACTTGA	0.294			NA											4	65					0.00909568	0.00944648	0.009096	1	0
FOXB2	442425	broad.mit.edu	37	9	79635163	79635163	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:79635163C>T	uc004ako.1	+	1	593	c.593C>T	c.(592-594)CCC>CTC	p.P198L		NM_001013735	NP_001013757	Q5VYV0	FOXB2_HUMAN	forkhead box B2	198					brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						CCGTCACAGCCCCCGCAGCAA	0.433			NA											9	15					0	0	0.004007	0	0
NTRK2	4915	broad.mit.edu	37	9	87635137	87635137	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:87635137T>A	uc004aoa.1	+	19	3079	c.2141T>A	c.(2140-2142)ATG>AAG	p.M714K	NTRK2_uc004anz.1_Missense_Mutation_p.M730K	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	714	Protein kinase.|Cytoplasmic (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						GGCCACACAATGCTGCCCATT	0.572			NA								TSP Lung(25;0.17)			29	77					0	0	0.008361	0	0
FBP1	2203	broad.mit.edu	37	9	97365818	97365818	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:97365818C>A	uc004auw.3	-	7	1193	c.862G>T	c.(862-864)GTC>TTC	p.V288F	FBP1_uc010mrl.2_Missense_Mutation_p.V288F	NM_000507	NP_000498	P09467	F16P1_HUMAN	fructose-1,6-bisphosphatase 1	288					gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(62;0.136)			Adenosine monophosphate(DB00131)	TTCTCCATGACGTAGGCCATG	0.542	Ovarian(142;590 2466 25593 44496)		NA									OREG0019330	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	40					1.3612e-06	1.66615e-06	0.003163	1	0
RNF20	56254	broad.mit.edu	37	9	104317049	104317049	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:104317049A>T	uc004bbn.2	+	15	2183	c.2093A>T	c.(2092-2094)GAG>GTG	p.E698V		NM_019592	NP_062538	Q5VTR2	BRE1A_HUMAN	ring finger protein 20	698	Potential.				histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|breast(1)|kidney(1)|skin(1)	8		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		ATGGCTGATGAGGATGCCTTG	0.423			NA											5	37					0	0	0.00308	0	0
LPAR1	1902	broad.mit.edu	37	9	113704146	113704146	+	Silent	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:113704146C>A	uc004bfa.2	-	4	603	c.348G>T	c.(346-348)CTG>CTT	p.L116L	LPAR1_uc011lwm.1_Silent_p.L117L|LPAR1_uc004bfb.2_Silent_p.L116L|LPAR1_uc004bfc.2_Silent_p.L116L|LPAR1_uc011lwn.1_Silent_p.L98L|LPAR1_uc011lwo.1_Silent_p.L117L|LPAR1_uc010mub.2_Silent_p.L116L	NM_057159	NP_476500	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	116	Extracellular (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				ovary(2)	2						TGCTAACAGTCAGTCTCCGAG	0.498	NSCLC(115;661 2323 9836 34256)		NA											47	91					2.65591e-33	4.61419e-33	0.00361	1	0
PAPPA	5069	broad.mit.edu	37	9	118950203	118950203	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:118950203G>T	uc004bjn.2	+	2	1567	c.1186G>T	c.(1186-1188)GAC>TAC	p.D396Y	PAPPA_uc011lxp.1_Missense_Mutation_p.D189Y|PAPPA_uc011lxq.1_Missense_Mutation_p.D189Y	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	396	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding	p.D396E(1)		ovary(4)|skin(4)|pancreas(1)	9						CTGGGAGCTGGACGTGCTGGA	0.577			NA											17	42					3.99206e-14	5.94864e-14	0.007413	1	0
DBC1	1620	broad.mit.edu	37	9	122004435	122004435	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:122004435C>A	uc004bkc.2	-	4	925	c.469G>T	c.(469-471)GCC>TCC	p.A157S	DBC1_uc004bkd.2_Missense_Mutation_p.A157S	NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	157	MACPF.				cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						CTTTGAGTGGCATTCCCTGAC	0.483			NA											26	54					9.04412e-07	1.10882e-06	0.004656	1	0
CDK5RAP2	55755	broad.mit.edu	37	9	123165113	123165113	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:123165113T>A	uc004bkf.2	-	34	5459	c.5278A>T	c.(5278-5280)AGC>TGC	p.S1760C	CDK5RAP2_uc010mvi.2_Missense_Mutation_p.S769C|CDK5RAP2_uc004bke.2_Missense_Mutation_p.S1045C|CDK5RAP2_uc004bkg.2_Missense_Mutation_p.S1681C|CDK5RAP2_uc011lxw.1_Missense_Mutation_p.S1025C|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Missense_Mutation_p.S1025C|CDK5RAP2_uc011lya.1_Missense_Mutation_p.S1025C|CDK5RAP2_uc004bkh.1_Missense_Mutation_p.S1530C	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1760	Interaction with PCNT and AKAP9.|Interaction with CDK5R1 (By similarity).				brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						CTTGTGGAGCTGGGAGCCTCT	0.577			NA											20	50					0	0	0.002299	0	0
DAB2IP	153090	broad.mit.edu	37	9	124536647	124536647	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:124536647A>T	uc004bln.2	+	13	3061	c.2992A>T	c.(2992-2994)AGG>TGG	p.R998W	DAB2IP_uc004blo.2_Missense_Mutation_p.R902W|DAB2IP_uc004blp.2_Missense_Mutation_p.R431W	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	1026	Potential.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						CCCCCCCCACAGGGATAGGCT	0.637			NA											4	24					0	0	0.009096	0	0
OR1L1	26737	broad.mit.edu	37	9	125424280	125424280	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:125424280G>T	uc011lza.1	+	1	436	c.436G>T	c.(436-438)GAG>TAG	p.E146*		NM_001005236	NP_001005236	Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L,	146	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						CTCTTACAGTGAGTGTCTGAC	0.433			NA											38	232					3.93418e-24	6.57732e-24	0.004289	1	0
OR1L1	26737	broad.mit.edu	37	9	125424286	125424286	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:125424286C>G	uc011lza.1	+	1	442	c.442C>G	c.(442-444)CTG>GTG	p.L148V		NM_001005236	NP_001005236	Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L,	148	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						CAGTGAGTGTCTGACCCAGAT	0.438			NA											17	258					0	0	0.007413	0	0
GARNL3	84253	broad.mit.edu	37	9	130111211	130111211	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:130111211G>T	uc011mae.1	+	17	1841	c.1440G>T	c.(1438-1440)GAG>GAT	p.E480D	GARNL3_uc011mad.1_Missense_Mutation_p.E458D	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	480					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						AGCCGTGGGAGCCCCAGTGTT	0.522			NA											25	43					3.28513e-13	4.80968e-13	0.003954	1	0
FAM102A	399665	broad.mit.edu	37	9	130710649	130710649	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:130710649C>T	uc004bsx.1	-	5	538	c.459G>A	c.(457-459)AAG>AAA	p.K153K	FAM102A_uc004bsw.1_Silent_p.K11K|FAM102A_uc004bsy.1_5'Flank	NM_001035254	NP_001030331	Q5T9C2	F102A_HUMAN	early estrogen-induced gene 1 protein isoform a	153										ovary(1)	1						GCACTCACGTCTTGAAGCAGG	0.617			NA											18	54					0	0	0.008871	0	0
SPTAN1	6709	broad.mit.edu	37	9	131343323	131343323	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:131343323G>C	uc004bvl.3	+	11	1559	c.1446G>C	c.(1444-1446)TGG>TGC	p.W482C	SPTAN1_uc011mbg.1_Missense_Mutation_p.W482C|SPTAN1_uc011mbh.1_Missense_Mutation_p.W494C|SPTAN1_uc004bvm.3_Missense_Mutation_p.W482C|SPTAN1_uc004bvn.3_Missense_Mutation_p.W482C	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	482	Spectrin 6.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGGACAACTGGATGAGCAAGC	0.572	NSCLC(120;833 1744 2558 35612 37579)		NA											12	94					0	0	0.001855	0	0
FAM78A	286336	broad.mit.edu	37	9	134136376	134136376	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr9:134136376C>A	uc004cak.2	-	2	1025	c.685G>T	c.(685-687)GCC>TCC	p.A229S	FAM78A_uc004caj.2_Missense_Mutation_p.A226S	NM_033387	NP_203745	Q5JUQ0	FA78A_HUMAN	hypothetical protein LOC286336	229										ovary(1)	1	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.15e-05)|Epithelial(140;0.000267)		CGCAGCCGGGCGCGCTGGCCC	0.652			NA											23	66					1.9806e-07	2.52685e-07	0.002299	1	0
ARSF	416	broad.mit.edu	37	X	2994711	2994711	+	Splice_Site	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chrX:2994711G>T	uc004cre.1	+	4	504	c.283_splice	c.e4+1	p.G95_splice	ARSF_uc004crf.1_Splice_Site_p.G95_splice	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor							extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ATCCGATCAGGTGCGCAAACT	0.547			NA											5	17					1.23904e-05	1.46662e-05	0.000602	1	0
PIGA	5277	broad.mit.edu	37	X	15349879	15349879	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chrX:15349879C>A	uc004cwr.2	-	2	274	c.174G>T	c.(172-174)CAG>CAT	p.Q58H	PIGA_uc004cwq.2_5'UTR|PIGA_uc010nev.2_Missense_Mutation_p.Q58H|PIGA_uc004cws.2_Intron|PIGA_uc011miq.1_Intron|PIGA_uc010new.1_Missense_Mutation_p.Q58H	NM_002641	NP_002632	P37287	PIGA_HUMAN	phosphatidylinositol	58	Cytoplasmic (Potential).				C-terminal protein lipidation|positive regulation of metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity|protein binding				0	Hepatocellular(33;0.183)					CAATCAGGCACTGAGAGAGCT	0.428			NA											22	36					4.35082e-09	5.81652e-09	0.010504	1	0
MAGEB6	158809	broad.mit.edu	37	X	26212607	26212607	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chrX:26212607C>A	uc004dbr.2	+	2	793	c.644C>A	c.(643-645)TCC>TAC	p.S215Y	MAGEB6_uc010ngc.1_5'UTR	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	215	MAGE.									ovary(3)	3						AAGAAAGAGTCCATTTTGAAG	0.468			NA											17	58					1.33834e-09	1.8052e-09	0.007413	1	0
MAGEB1	4112	broad.mit.edu	37	X	30269404	30269404	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chrX:30269404C>A	uc004dcc.2	+	4	1114	c.794C>A	c.(793-795)CCC>CAC	p.P265H	MAGEB1_uc004dcd.2_Missense_Mutation_p.P265H|MAGEB1_uc004dce.2_Missense_Mutation_p.P265H	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	265	MAGE.										0						AACAGTGATCCCCCACGCTAT	0.507			NA											24	33					4.26978e-12	6.12055e-12	0.00333	1	0
CXorf22	170063	broad.mit.edu	37	X	35974241	35974241	+	Silent	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chrX:35974241G>T	uc004ddj.2	+	8	1397	c.1338G>T	c.(1336-1338)ACG>ACT	p.T446T	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	446										large_intestine(1)|lung(1)|ovary(1)	3						TTCCTGTGACGTACCACTTTA	0.353			NA											14	33					4.3838e-07	5.49981e-07	0.001855	1	0
CCNB3	85417	broad.mit.edu	37	X	50094639	50094639	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chrX:50094639G>T	uc004dox.3	+	13	4423	c.4125G>T	c.(4123-4125)TTG>TTT	p.L1375F	CCNB3_uc004doy.2_Missense_Mutation_p.L1375F|CCNB3_uc004doz.2_Missense_Mutation_p.L271F|CCNB3_uc010njq.2_Missense_Mutation_p.L267F|CCNB3_uc004dpa.2_Missense_Mutation_p.L214F	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1375					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					TCCCTGCCTTGGATATGTTGA	0.483			NA											10	21					0.00829132	0.00867081	0.008291	1	0
ZCCHC5	203430	broad.mit.edu	37	X	77912812	77912812	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chrX:77912812A>G	uc004edc.1	-	2	1402	c.1106T>C	c.(1105-1107)ATA>ACA	p.I369T		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	369							nucleic acid binding|zinc ion binding			ovary(1)	1						TTCATCTTGTATAGAACTGGC	0.488			NA											19	32					0	0	0.001882	0	0
PCDH11X	27328	broad.mit.edu	37	X	91132808	91132808	+	Silent	SNP	T	T	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chrX:91132808T>A	uc004efk.1	+	2	2414	c.1569T>A	c.(1567-1569)ACT>ACA	p.T523T	PCDH11X_uc004efl.1_Silent_p.T523T|PCDH11X_uc004efo.1_Silent_p.T523T|PCDH11X_uc010nmv.1_Silent_p.T523T|PCDH11X_uc004efm.1_Silent_p.T523T|PCDH11X_uc004efn.1_Silent_p.T523T|PCDH11X_uc004efh.1_Silent_p.T523T|PCDH11X_uc004efj.1_Silent_p.T523T	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	523	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						GCATGCTGACTGTAGTGAAGA	0.438	NSCLC(38;925 1092 2571 38200 45895)		NA											10	32					0	0	0.006214	0	0
TRMT2B	79979	broad.mit.edu	37	X	100292981	100292981	+	Silent	SNP	G	G	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chrX:100292981G>C	uc004egq.2	-	4	662	c.363C>G	c.(361-363)CTC>CTG	p.L121L	TRMT2B_uc004egp.2_RNA|TRMT2B_uc004egr.2_Silent_p.L121L|TRMT2B_uc004egs.2_Silent_p.L121L|TRMT2B_uc004egt.2_Silent_p.L121L|TRMT2B_uc004egu.2_Silent_p.L2L|TRMT2B_uc004egv.2_Intron	NM_024917	NP_079193	Q96GJ1	TRM2_HUMAN	TRM2 tRNA methyltransferase 2 homolog B	121							tRNA (uracil-5-)-methyltransferase activity			ovary(1)	1						TGACTCCATTGAGCATTTGGA	0.398			NA											70	150					0	0	0.00361	0	0
BHLHB9	80823	broad.mit.edu	37	X	102004718	102004718	+	Silent	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chrX:102004718C>T	uc010nog.2	+	4	1366	c.795C>T	c.(793-795)TGC>TGT	p.C265C	BHLHB9_uc011mrq.1_Silent_p.C265C|BHLHB9_uc011mrr.1_Silent_p.C265C|BHLHB9_uc011mrs.1_Silent_p.C265C|BHLHB9_uc011mrt.1_Silent_p.C265C|BHLHB9_uc004ejo.2_Silent_p.C265C|BHLHB9_uc011mru.1_Silent_p.C265C|BHLHB9_uc011mrv.1_Silent_p.C265C	NM_001142526	NP_001135998	Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class	265						cytoplasm|nucleus	binding			ovary(2)	2						CAACAGCTTGCCGCCCTTCTA	0.502			NA											15	35					0	0	0.00245	0	0
IRS4	8471	broad.mit.edu	37	X	107977627	107977627	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chrX:107977627C>A	uc004eoc.2	-	1	1981	c.1948G>T	c.(1948-1950)GGG>TGG	p.G650W		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	650						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						AATCTTCCCCCAGACTTCCCT	0.498			NA											57	131					4.54978e-40	7.94106e-40	0.00361	1	0
RGAG1	57529	broad.mit.edu	37	X	109695399	109695399	+	Silent	SNP	A	A	G			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chrX:109695399A>G	uc004eor.1	+	3	1800	c.1554A>G	c.(1552-1554)ACA>ACG	p.T518T	RGAG1_uc011msr.1_Silent_p.T518T	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	518										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						TTACGGCAACAGCCTCTGAAA	0.512			NA											42	91					0	0	0.007835	0	0
FAM70A	55026	broad.mit.edu	37	X	119410766	119410766	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chrX:119410766C>T	uc004eso.3	-	8	948	c.721G>A	c.(721-723)GCT>ACT	p.A241T	FAM70A_uc004esp.3_Missense_Mutation_p.A217T|FAM70A_uc010nqo.2_Intron	NM_017938	NP_060408	Q5JRV8	FA70A_HUMAN	hypothetical protein LOC55026 isoform 1	241	Helical; (Potential).					integral to membrane				lung(1)|breast(1)	2						CCAAGGACAGCGGCAGTGATG	0.527			NA											9	49					0	0	0.006214	0	0
FAM70A	55026	broad.mit.edu	37	X	119410810	119410810	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chrX:119410810G>A	uc004eso.3	-	8	904	c.677C>T	c.(676-678)ACC>ATC	p.T226I	FAM70A_uc004esp.3_Missense_Mutation_p.T202I|FAM70A_uc010nqo.2_Intron	NM_017938	NP_060408	Q5JRV8	FA70A_HUMAN	hypothetical protein LOC55026 isoform 1	226	Helical; (Potential).					integral to membrane				lung(1)|breast(1)	2						GTTGAGGATGGTGGCAGACCA	0.507			NA											32	50					0	0	0.002836	0	0
ODZ1	10178	broad.mit.edu	37	X	123785874	123785874	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chrX:123785874G>T	uc004euj.2	-	8	1533	c.1469C>A	c.(1468-1470)TCG>TAG	p.S490*	ODZ1_uc011muj.1_Nonsense_Mutation_p.S489*|ODZ1_uc010nqy.2_Nonsense_Mutation_p.S490*	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	490	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CTCCTGAAGCGAAGTTAAGAT	0.428			NA											27	45					1.08971e-26	1.85892e-26	0.00632	1	0
RAB39B	116442	broad.mit.edu	37	X	154490296	154490296	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chrX:154490296T>C	uc004fne.2	-	2	713	c.434A>G	c.(433-435)TAC>TGC	p.Y145C		NM_171998	NP_741995	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	145					protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CTTCATGCCGTATGCAGCAGC	0.498			NA											35	27					0	0	0.002445	0	0
SNX7	51375	broad.mit.edu	37	1	99156727	99156727	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr1:99156727delA	uc010ouc.1	+	3	512	c.460delA	c.(460-462)ACTfs	p.T154fs	SNX7_uc001dsa.2_Frame_Shift_Del_p.T90fs|SNX7_uc010oud.1_Frame_Shift_Del_p.T154fs	NM_015976	NP_057060	Q9UNH6	SNX7_HUMAN	sorting nexin 7 isoform a	90	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		AGCACACCCCACTCTGATTAT	0.373			NA											15	39	---	---	---	---	NA	NA	NA	NA	NA
ZIC2	7546	broad.mit.edu	37	13	100635008	100635010	+	In_Frame_Del	DEL	CCA	CCA	-			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	CCA	CCA	-	-	CCA	CCA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr13:100635008_100635010delCCA	uc001von.2	+	1	690_692	c.690_692delCCA	c.(688-693)GCCCAC>GCC	p.H239del		NM_007129	NP_009060	O95409	ZIC2_HUMAN	zinc finger protein of the cerebellum 2	239	Necessary for interaction with MDFIC and transcriptional activation or repression (By similarity).|Poly-His.		Missing.|H -> HH.		brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CAGCCGCGGCccaccaccaccac	0.522	Pancreas(97;119 1522 31925 44771 48764)		NA											7	56	---	---	---	---	NA	NA	NA	NA	NA
BAIAP3	8938	broad.mit.edu	37	16	1395754	1395754	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr16:1395754delC	uc002clk.1	+	23	2176	c.2176delC	c.(2176-2178)CCCfs	p.P726fs	BAIAP3_uc002clj.2_Frame_Shift_Del_p.P708fs|BAIAP3_uc010uuz.1_Frame_Shift_Del_p.P691fs|BAIAP3_uc010uva.1_Frame_Shift_Del_p.P663fs|BAIAP3_uc010uvc.1_Frame_Shift_Del_p.P655fs	NM_003933	NP_003924	O94812	BAIP3_HUMAN	BAI1-associated protein 3	726	MHD1.				G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			pancreas(1)	1		Hepatocellular(780;0.0893)				cTAGCTGGAGCCCGTGGACGC	0.373			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
MUC16	94025	broad.mit.edu	37	19	9046473	9046473	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:9046473delC	uc002mkp.2	-	5	35362	c.35158delG	c.(35158-35160)GCCfs	p.A11720fs		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11722	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGACTGGTGGCCATTACAGGT	0.517			NA											55	118	---	---	---	---	NA	NA	NA	NA	NA
MUC16	94025	broad.mit.edu	37	19	9087356	9087357	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr19:9087356_9087357insA	uc002mkp.2	-	1	4662_4663	c.4458_4459insT	c.(4456-4461)TTTGCTfs	p.F1486fs		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1486_1487	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGAAAAATAGCAAATGTACTCA	0.431			NA											55	158	---	---	---	---	NA	NA	NA	NA	NA
ADAM23	8745	broad.mit.edu	37	2	207431999	207431999	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr2:207431999delT	uc002vbq.2	+	15	1670	c.1447delT	c.(1447-1449)TTTfs	p.F483fs	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	483	Peptidase M12B.|Extracellular (Potential).				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		GTATAGAGACTTTTTACAGAG	0.358	Melanoma(194;1127 2130 19620 24042 27855)		NA											41	96	---	---	---	---	NA	NA	NA	NA	NA
CRMP1	1400	broad.mit.edu	37	4	5862865	5862865	+	Frame_Shift_Del	DEL	G	G	-	rs145307270		TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr4:5862865delG	uc003gip.2	-	4	302	c.201delC	c.(199-201)CCCfs	p.P67fs	CRMP1_uc003gin.1_Intron|CRMP1_uc003giq.2_Frame_Shift_Del_p.P67fs|CRMP1_uc003gir.2_Frame_Shift_Del_p.P62fs|CRMP1_uc003gis.2_Frame_Shift_Del_p.P181fs	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2	67					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)		CAATACCTCCGGGAATAACCA	0.552			NA											14	117	---	---	---	---	NA	NA	NA	NA	NA
EEF1E1	9521	broad.mit.edu	37	6	8097553	8097553	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:8097553delC	uc003mxz.2	-	2	309	c.235delG	c.(235-237)GTCfs	p.V79fs	EEF1E1_uc011dic.1_Frame_Shift_Del_p.V79fs	NM_004280	NP_004271	O43324	MCA3_HUMAN	eukaryotic translation elongation factor 1	79	GST C-terminal.				negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of DNA damage response, signal transduction by p53 class mediator|tRNA aminoacylation for protein translation	cytosol|nucleus					0	Ovarian(93;0.0398)					ACTTGAGTGACCCTGTATTCT	0.418			NA											46	221	---	---	---	---	NA	NA	NA	NA	NA
HIST1H3E	8353	broad.mit.edu	37	6	26225624	26225624	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr6:26225624delC	uc003nhb.2	+	2	602	c.242delC	c.(241-243)ACCfs	p.T81fs	HIST1H3E_uc003nhc.3_Frame_Shift_Del_p.T81fs	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	81					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0223)|Acute lymphoblastic leukemia(11;0.0351)				GACTTCAAGACCGACCTGCGC	0.592			NA											14	82	---	---	---	---	NA	NA	NA	NA	NA
FOXP2	93986	broad.mit.edu	37	7	114282627	114282627	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:114282627delA	uc003vhb.2	+	7	1312	c.938delA	c.(937-939)CATfs	p.H313fs	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Frame_Shift_Del_p.H338fs|FOXP2_uc003vha.2_Frame_Shift_Del_p.H221fs|FOXP2_uc011kmu.1_Frame_Shift_Del_p.H330fs|FOXP2_uc011kmv.1_Frame_Shift_Del_p.H312fs|FOXP2_uc010ljz.1_Frame_Shift_Del_p.H221fs|FOXP2_uc003vgx.2_Frame_Shift_Del_p.H313fs|FOXP2_uc003vhd.2_Frame_Shift_Del_p.H313fs|FOXP2_uc003vhc.2_Frame_Shift_Del_p.H338fs	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	313					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						CCAATAACTCATCATTCCATA	0.388			NA											18	161	---	---	---	---	NA	NA	NA	NA	NA
KCND2	3751	broad.mit.edu	37	7	120382616	120382616	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr7:120382616delC	uc003vjj.1	+	4	2392	c.1427delC	c.(1426-1428)ACCfs	p.T476fs		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	476	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding	p.T476T(1)		ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					AGCTTTGAAACCCAGCACCAC	0.453			NA											24	141	---	---	---	---	NA	NA	NA	NA	NA
ZFHX4	79776	broad.mit.edu	37	8	77618211	77618211	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7662-01A-11D-2063-08	TCGA-44-7662-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c35f0ace-0012-4ad4-90de-617f5d764f42	c322f1e3-cf36-4f3a-9dca-18ec91ff9136	g.chr8:77618211delG	uc003yav.2	+	2	2275	c.1888delG	c.(1888-1890)GGTfs	p.G630fs	ZFHX4_uc003yat.1_Frame_Shift_Del_p.G630fs|ZFHX4_uc003yau.1_Frame_Shift_Del_p.G630fs|ZFHX4_uc003yaw.1_Frame_Shift_Del_p.G630fs	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	630	C2H2-type 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GTCTCTTGGTGGTCATATGAC	0.527			NA								HNSCC(33;0.089)			23	50	---	---	---	---	NA	NA	NA	NA	NA
