Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TAS1R3	83756	broad.mit.edu	37	1	1267812	1267812	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:1267812G>A	uc010nyk.1	+	3	901	c.901G>A	c.(901-903)GAG>AAG	p.E301K		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	301	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	GGTGGCCAGCGAGGCCTGGCT	0.672			NA											8	8					0	0	0.004482	0	0
Unknown	0	broad.mit.edu	37	1	1853744	1853744	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:1853744C>A	uc001aik.2	-	11	1750	c.900G>T	c.(898-900)CAG>CAT	p.Q300H	uc001ail.2_Missense_Mutation_p.Q300H					RecName: Full=Uncharacterized protein C1orf222;												NA						CAGTCAACACCTGGGCTACAA	0.617			NA											22	29					2.3814e-25	4.34132e-25	0.00333	1	0
PLCH2	9651	broad.mit.edu	37	1	2435853	2435853	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:2435853C>A	uc001aji.1	+	22	3726	c.3452C>A	c.(3451-3453)TCC>TAC	p.S1151Y	PLCH2_uc010nyz.1_3'UTR|PLCH2_uc009vle.1_Missense_Mutation_p.S903Y|PLCH2_uc001ajj.1_3'UTR|PLCH2_uc001ajk.1_3'UTR|PLCH2_uc001ajl.1_Missense_Mutation_p.S3Y	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	1151					intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		AGCATGTCATCCAGCGACACT	0.682			NA											17	30					6.94344e-10	9.19416e-10	0.006122	1	0
CAMTA1	23261	broad.mit.edu	37	1	7527931	7527931	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:7527931C>T	uc001aoi.2	+	6	687	c.480C>T	c.(478-480)ACC>ACT	p.T160T		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	160	CG-1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TCATCCCCACCTTCCACCGGA	0.478			NA											49	91					0	0	0.00361	0	0
SLC45A1	50651	broad.mit.edu	37	1	8390674	8390674	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:8390674A>G	uc001apb.2	+	4	1121	c.1121A>G	c.(1120-1122)GAC>GGC	p.D374G	SLC45A1_uc001apc.2_Missense_Mutation_p.D72G	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	374					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GCCAACATAGACAGCGTCCTC	0.662			NA											10	24					0	0	0.008291	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12921424	12921424	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:12921424C>A	uc001aum.1	+	4	1302	c.1215C>A	c.(1213-1215)AGC>AGA	p.S405R		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	405											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GTGGGCTGAGCAAGTTAAGCC	0.552			NA											36	75					1.47244e-24	2.66073e-24	0.00623	1	0
RSC1A1	6248	broad.mit.edu	37	1	15987376	15987376	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:15987376G>T	uc010obn.1	+	1	1013	c.1013G>T	c.(1012-1014)TGT>TTT	p.C338F		NM_006511	NP_006502	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1,	338					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			ovary(1)	1		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TGTGGCAGTTGTCAGCCTTCT	0.433			NA											13	37					2.27111e-07	2.78718e-07	0.001368	1	0
PAX7	5081	broad.mit.edu	37	1	19018324	19018324	+	Silent	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:19018324G>C	uc001bay.2	+	5	1261	c.663G>C	c.(661-663)CGG>CGC	p.R221R	PAX7_uc001baz.2_Silent_p.R219R|PAX7_uc010oct.1_Silent_p.R221R	NM_002584	NP_002575	P23759	PAX7_HUMAN	paired box 7 isoform 1	221	Homeobox.				anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	soft_tissue(197)|lung(3)|prostate(1)|ovary(1)|breast(1)	203		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		GACGCAGTCGGACCACATTCA	0.637			NA	T	FOXO1A	alveolar rhabdomyosarcoma								7	11					0	0	0.001984	0	0
UBR4	23352	broad.mit.edu	37	1	19467338	19467338	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:19467338T>C	uc001bbi.2	-	58	8541	c.8537A>G	c.(8536-8538)CAG>CGG	p.Q2846R	UBR4_uc001bbk.1_Intron	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2846					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GCTGGGTGCCTGGCCGGACAG	0.632			NA											8	9					0	0	0.004482	0	0
UBR4	23352	broad.mit.edu	37	1	19511665	19511665	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:19511665C>A	uc001bbi.2	-	15	1870	c.1866G>T	c.(1864-1866)CGG>CGT	p.R622R		NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	622	Pro-rich.				interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GGCTTTTAACCCGAGGAGAGC	0.527			NA											57	139					7.10676e-39	1.35197e-38	0.00361	1	0
HSPG2	3339	broad.mit.edu	37	1	22181236	22181236	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:22181236C>A	uc001bfj.2	-	49	6196	c.6156G>T	c.(6154-6156)CCG>CCT	p.P2052P	HSPG2_uc009vqd.2_Silent_p.P2053P	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2052	Ig-like C2-type 6.			P -> G (in Ref. 1; AAA52700).	angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CAATCTTGACCGGCGGTGGGC	0.637			NA											3	10					6.4e-05	7.21159e-05	0.004672	1	0
IL28RA	163702	broad.mit.edu	37	1	24484118	24484118	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:24484118C>G	uc001bis.2	-	7	1078	c.1065G>C	c.(1063-1065)CAG>CAC	p.Q355H	IL28RA_uc001bir.2_Missense_Mutation_p.Q326H|IL28RA_uc001bit.2_3'UTR|IL28RA_uc001biu.2_Missense_Mutation_p.Q271H	NM_170743	NP_734464	Q8IU57	I28RA_HUMAN	interleukin 28 receptor, alpha isoform 1	355	Cytoplasmic (Potential).				cytokine-mediated signaling pathway|negative regulation of cell proliferation|regulation of defense response to virus by host	interleukin-28 receptor complex	protein binding|receptor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00117)|all_lung(284;0.00151)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.21e-24)|Colorectal(126;6.61e-08)|COAD - Colon adenocarcinoma(152;3.56e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00918)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.185)		GCCCTGGAGCCTGGTGCTCTT	0.597			NA											17	24					0	0	0.00499	0	0
ARID1A	8289	broad.mit.edu	37	1	27087527	27087527	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:27087527G>T	uc001bmv.1	+	5	2474	c.2101G>T	c.(2101-2103)GGC>TGC	p.G701C	ARID1A_uc001bmt.1_Missense_Mutation_p.G701C|ARID1A_uc001bmu.1_Missense_Mutation_p.G701C|ARID1A_uc001bmw.1_Missense_Mutation_p.G318C	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	701					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GTCCCCTGTTGGCTCTCCCGC	0.607			NA	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								23	33					1.64293e-13	2.43987e-13	0.00333	1	0
GPATCH3	63906	broad.mit.edu	37	1	27220829	27220829	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:27220829T>A	uc001bne.2	-	3	978	c.949A>T	c.(949-951)ACT>TCT	p.T317S	GPATCH3_uc009vsp.1_Missense_Mutation_p.T128S	NM_022078	NP_071361	Q96I76	GPTC3_HUMAN	G patch domain containing 3	317	Glu-rich.					intracellular	nucleic acid binding				0		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.97e-51)|OV - Ovarian serous cystadenocarcinoma(117;9.55e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|STAD - Stomach adenocarcinoma(196;0.000595)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|READ - Rectum adenocarcinoma(331;0.0419)		AGCTGCTCAGTGGTCCGCTCC	0.572			NA											25	91					0	0	0.00632	0	0
RCC1	1104	broad.mit.edu	37	1	28861844	28861844	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:28861844G>T	uc001bqg.1	+	6	698	c.613G>T	c.(613-615)GGC>TGC	p.G205C	SNHG3-RCC1_uc001bqa.1_Missense_Mutation_p.G205C|SNHG3-RCC1_uc001bqb.1_Missense_Mutation_p.G205C|SNHG3-RCC1_uc001bqc.1_Missense_Mutation_p.G205C|RCC1_uc001bqe.1_Missense_Mutation_p.G222C|RCC1_uc001bqf.1_Missense_Mutation_p.G236C	NM_001269	NP_001260	P18754	RCC1_HUMAN	regulator of chromosome condensation 1 isoform	205	RCC1 4.				cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		GGGCCAGCTAGGCCGTGTGCC	0.587			NA											15	34					3.27435e-08	4.14541e-08	0.00245	1	0
SFRS4	6429	broad.mit.edu	37	1	29481229	29481229	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:29481229G>T	uc001bro.2	-	4	930	c.557C>A	c.(556-558)TCC>TAC	p.S186Y	SFRS4_uc010ofy.1_Intron|SFRS4_uc009vtp.2_RNA	NM_005626	NP_005617	Q08170	SRSF4_HUMAN	splicing factor, arginine/serine-rich 4	186	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding				0		Colorectal(325;0.00161)|Breast(348;0.0364)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0529)|Lung NSC(340;0.0654)|all_lung(284;0.074)|Ovarian(437;0.104)|Medulloblastoma(700;0.151)		Colorectal(126;1.01e-07)|COAD - Colon adenocarcinoma(152;6.21e-06)|STAD - Stomach adenocarcinoma(196;0.0196)|BRCA - Breast invasive adenocarcinoma(304;0.0531)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.138)		CCGGCTTCTGGAGTAGGACCG	0.403			NA											19	25					9.95505e-16	1.55696e-15	0.002299	1	0
COL16A1	1307	broad.mit.edu	37	1	32162668	32162668	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:32162668C>A	uc001btk.1	-	8	1125	c.760G>T	c.(760-762)GCC>TCC	p.A254S	COL16A1_uc001btj.1_Missense_Mutation_p.A83S|COL16A1_uc001btl.3_Missense_Mutation_p.A254S	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	254	Nonhelical region 10 (NC10).				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		TCCCGGCGGGCCTTGGAGGTC	0.587	Colon(143;498 1786 21362 25193 36625)		NA											19	58					1.28384e-07	1.59183e-07	0.001882	1	0
CSMD2	114784	broad.mit.edu	37	1	34123566	34123566	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:34123566G>T	uc001bxn.1	-	27	4336	c.4307C>A	c.(4306-4308)CCC>CAC	p.P1436H	CSMD2_uc001bxm.1_Missense_Mutation_p.P1476H|CSMD2_uc001bxo.1_Missense_Mutation_p.P349H	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1436	Extracellular (Potential).|Sushi 8.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGGCGGGCTGGGCTGCCAGAA	0.592			NA											24	44					1.5548e-18	2.57113e-18	0.005443	1	0
CSMD2	114784	broad.mit.edu	37	1	34286079	34286079	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:34286079G>T	uc001bxn.1	-	8	1099	c.1070C>A	c.(1069-1071)TCG>TAG	p.S357*	CSMD2_uc001bxm.1_Nonsense_Mutation_p.S397*	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	357	Extracellular (Potential).|Sushi 2.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCTGAAATCCGAGCCTAGTCT	0.488			NA											47	113					1.11015e-26	2.04188e-26	0.00361	1	0
ZMYM6	9204	broad.mit.edu	37	1	35457958	35457958	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:35457958G>A	uc001byh.2	-	15	2251	c.2023C>T	c.(2023-2025)CCA>TCA	p.P675S	ZMYM6_uc001byf.1_Missense_Mutation_p.P675S|ZMYM6_uc010oht.1_Missense_Mutation_p.P578S|ZMYM6_uc009vup.2_Missense_Mutation_p.P481S|ZMYM6_uc009vuq.1_Missense_Mutation_p.P675S	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	675					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				TGGGAAGATGGAAATTTCATA	0.383			NA											25	40					0	0	0.003954	0	0
ZMYM4	9202	broad.mit.edu	37	1	35852719	35852719	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:35852719C>T	uc001byt.2	+	12	2032	c.1952C>T	c.(1951-1953)TCT>TTT	p.S651F	ZMYM4_uc009vuu.2_Missense_Mutation_p.S619F|ZMYM4_uc001byu.2_Missense_Mutation_p.S327F|ZMYM4_uc009vuv.2_Missense_Mutation_p.S390F	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	651					multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GGTAGCACATCTGCTGTTTCT	0.537			NA											14	22					0	0	0.00245	0	0
EIF2C4	192670	broad.mit.edu	37	1	36299636	36299636	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:36299636G>T	uc001bzj.1	+	12	1615	c.1425G>T	c.(1423-1425)ATG>ATT	p.M475I		NM_017629	NP_060099	Q9HCK5	AGO4_HUMAN	eukaryotic translation initiation factor 2C, 4	475					mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ATGCAGGAATGCCCATCCAGG	0.433			NA											20	44					5.35356e-11	7.35923e-11	0.00278	1	0
EIF2C1	26523	broad.mit.edu	37	1	36354197	36354197	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:36354197C>T	uc001bzl.2	+	2	408	c.195C>T	c.(193-195)CCC>CCT	p.P65P	EIF2C1_uc001bzk.2_5'UTR	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	65					negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ATAAGTGTCCCCGTAGAGTCA	0.403			NA											13	34					0	0	0.001368	0	0
COL8A2	1296	broad.mit.edu	37	1	36563225	36563225	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:36563225T>C	uc001bzv.1	-	2	2064	c.2057A>G	c.(2056-2058)TAC>TGC	p.Y686C	COL8A2_uc001bzw.1_Missense_Mutation_p.Y621C	NM_005202	NP_005193	P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2 precursor	686	C1q.|Nonhelical region (NC1).				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CTCCGTGGAGTAGAGGCCGTT	0.647			NA											11	28					0	0	0.008291	0	0
C1orf113	79729	broad.mit.edu	37	1	36786094	36786094	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:36786094G>T	uc010oia.1	+	14	1858	c.1830G>T	c.(1828-1830)AGG>AGT	p.R610S	C1orf113_uc010oib.1_Missense_Mutation_p.R499S|C1orf113_uc010oic.1_RNA|C1orf113_uc009vuz.1_Missense_Mutation_p.R256S	NM_001162530	NP_001156002	A4FU49	SH321_HUMAN	SH3 domain-containing protein C1orf113 isoform	494											0		Myeloproliferative disorder(586;0.0393)				ACGAGCAGAGGCCTCTGAGAG	0.592			NA											13	32					1.5842e-08	2.03602e-08	0.001855	1	0
RRAGC	64121	broad.mit.edu	37	1	39317399	39317399	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:39317399C>A	uc001ccq.2	-	5	809	c.787G>T	c.(787-789)GAT>TAT	p.D263Y	RRAGC_uc010oim.1_Missense_Mutation_p.D229Y|RRAGC_uc001ccr.2_Missense_Mutation_p.D185Y	NM_022157	NP_071440	Q9HB90	RRAGC_HUMAN	Ras-related GTP binding C	263					apoptosis|cell growth|cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|RNA splicing|small GTPase mediated signal transduction|transcription, DNA-dependent	lysosome|nucleus	GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein heterodimerization activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)				CTGACAACATCAAAGAGAAAA	0.338			NA											12	39					9.05144e-12	1.27963e-11	0.001855	1	0
RLF	6018	broad.mit.edu	37	1	40702175	40702175	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:40702175G>T	uc001cfc.3	+	8	1832	c.1801G>T	c.(1801-1803)GTG>TTG	p.V601L	RLF_uc001cfd.3_Missense_Mutation_p.V292L	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	601	C2H2-type 1.				chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			TGTTCCTCATGTGATGGAGCA	0.363			NA											16	31					6.72482e-11	9.22664e-11	0.003163	1	0
PTPRF	5792	broad.mit.edu	37	1	44071284	44071284	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:44071284G>T	uc001cjr.2	+	19	3814	c.3474G>T	c.(3472-3474)GAG>GAT	p.E1158D	PTPRF_uc001cjs.2_Missense_Mutation_p.E1149D|PTPRF_uc001cju.2_Missense_Mutation_p.E536D|PTPRF_uc009vwt.2_Missense_Mutation_p.E718D|PTPRF_uc001cjv.2_Missense_Mutation_p.E618D|PTPRF_uc001cjw.2_Missense_Mutation_p.E384D	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1158	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGGAACTGGAGCTGGACGAGG	0.627			NA											8	21					1.58986e-06	1.8947e-06	0.008291	1	0
KDM4A	9682	broad.mit.edu	37	1	44128655	44128655	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:44128655C>A	uc001cjx.2	+	5	686	c.520C>A	c.(520-522)CCA>ACA	p.P174T	KDM4A_uc010oki.1_Missense_Mutation_p.P174T	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	174	JmjC.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						TGTGAACACCCCATACCTGTA	0.493			NA											32	80					2.80507e-11	3.88934e-11	0.002445	1	0
ELAVL4	1996	broad.mit.edu	37	1	50666841	50666841	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:50666841C>A	uc001csb.2	+	7	1402	c.1134C>A	c.(1132-1134)CAC>CAA	p.H378Q	ELAVL4_uc001cry.3_Missense_Mutation_p.H367Q|ELAVL4_uc001crz.3_Missense_Mutation_p.H364Q|ELAVL4_uc001csa.3_Missense_Mutation_p.H381Q|ELAVL4_uc001csc.3_Missense_Mutation_p.H364Q|ELAVL4_uc010omz.1_Missense_Mutation_p.H369Q	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	378					mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						ACAAAGCCCACAAGTCCTGAA	0.448			NA											7	20					0.00307968	0.003275	0.00308	1	0
ZYG11B	79699	broad.mit.edu	37	1	53279551	53279551	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:53279551G>T	uc001cuj.2	+	12	2108	c.1913G>T	c.(1912-1914)TGG>TTG	p.W638L	ZYG11B_uc009vzg.2_RNA|ZYG11B_uc010onj.1_Missense_Mutation_p.W559L|ZYG11B_uc009vzh.2_Missense_Mutation_p.W60L	NM_024646	NP_078922	Q9C0D3	ZY11B_HUMAN	zyg-11 homolog B	638							protein binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						ATTTTGAAATGGCCAACTCCA	0.353			NA											20	34					1.50039e-11	2.10463e-11	0.001882	1	0
ACOT11	26027	broad.mit.edu	37	1	55067020	55067020	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:55067020G>T	uc001cxm.1	+	9	1045	c.963G>T	c.(961-963)ATG>ATT	p.M321I	ACOT11_uc001cxj.1_Missense_Mutation_p.M199I|ACOT11_uc001cxl.1_Missense_Mutation_p.M321I	NM_015547	NP_056362	Q8WXI4	ACO11_HUMAN	thioesterase, adipose associated isoform BFIT1	321	Acyl coenzyme A hydrolase 2.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			central_nervous_system(1)	1						GTGCCTTTATGACCTTTGTGG	0.657	Ovarian(148;1440 1861 22015 32453 51933)		NA											29	55					2.2171e-23	3.95187e-23	0.009535	1	0
C1orf175	374977	broad.mit.edu	37	1	55136487	55136487	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:55136487C>T	uc010ooe.1	+	7	1808	c.1484C>T	c.(1483-1485)ACC>ATC	p.T495I	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Missense_Mutation_p.T63I|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Missense_Mutation_p.T13I|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Missense_Mutation_p.T495I|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	495						integral to membrane	binding				0						ACCCAGCCCACCCTGGGCATG	0.622			NA											10	23					0	0	0.008291	0	0
USP24	23358	broad.mit.edu	37	1	55563650	55563650	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:55563650C>A	uc001cyg.3	-	44	5081	c.5081G>T	c.(5080-5082)AGT>ATT	p.S1694I		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	1854					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						GTACGCATTACTTCCTTCTAG	0.348			NA											28	38					4.66903e-05	5.28887e-05	0.002096	1	0
C1orf168	199920	broad.mit.edu	37	1	57254653	57254653	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:57254653C>A	uc001cym.3	-	3	1318	c.912G>T	c.(910-912)CAG>CAT	p.Q304H	C1orf168_uc009vzu.1_RNA|C1orf168_uc009vzv.1_Missense_Mutation_p.Q304H	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	304										ovary(3)|skin(2)	5						TACCTTCCCCCTGAGTCTTGG	0.597			NA											27	72					6.07407e-21	1.04896e-20	0.007291	1	0
C8B	732	broad.mit.edu	37	1	57406634	57406634	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:57406634C>A	uc001cyp.2	-	9	1353	c.1286G>T	c.(1285-1287)GGA>GTA	p.G429V	C8B_uc010oon.1_Missense_Mutation_p.G367V|C8B_uc010ooo.1_Missense_Mutation_p.G377V	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	429	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						ACTTGCCCCTCCTCGTACCAG	0.587			NA											19	21					7.07596e-05	7.95287e-05	0.006122	1	0
KANK4	163782	broad.mit.edu	37	1	62732417	62732417	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:62732417G>T	uc001dah.3	-	6	2683	c.2306C>A	c.(2305-2307)ACA>AAA	p.T769K	KANK4_uc001dai.3_Missense_Mutation_p.T141K|KANK4_uc001dag.3_Missense_Mutation_p.T125K	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	769										ovary(3)|skin(2)|lung(1)	6						GAGCTGGTCTGTGGTGGTCCC	0.423			NA											26	50					2.61193e-14	3.96464e-14	0.009535	1	0
DOCK7	85440	broad.mit.edu	37	1	63001286	63001286	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:63001286C>A	uc001daq.2	-	29	3523	c.3489G>T	c.(3487-3489)ACG>ACT	p.T1163T	DOCK7_uc001dan.2_Silent_p.T1024T|DOCK7_uc001dao.2_Silent_p.T1024T|DOCK7_uc001dap.2_Silent_p.T1132T|DOCK7_uc001dam.2_Silent_p.T343T|DOCK7_uc010oov.1_5'UTR	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1163					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						CTTGTACATTCGTAGAAAATC	0.398			NA											13	22					0.00498961	0.00525567	0.00499	1	0
SGIP1	84251	broad.mit.edu	37	1	67199493	67199493	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:67199493C>G	uc001dcr.2	+	21	2178	c.1961C>G	c.(1960-1962)ACT>AGT	p.T654S	SGIP1_uc010opd.1_Missense_Mutation_p.T254S|SGIP1_uc001dcs.2_Missense_Mutation_p.T254S|SGIP1_uc001dct.2_Missense_Mutation_p.T256S|SGIP1_uc009wat.2_Missense_Mutation_p.T448S|SGIP1_uc001dcu.2_Missense_Mutation_p.T159S	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	654					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						AATTTGATGACTCACCTAAAG	0.358			NA											29	51					0	0	0.005443	0	0
SLC44A5	204962	broad.mit.edu	37	1	75740677	75740677	+	Missense_Mutation	SNP	C	C	A	rs143283722		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:75740677C>A	uc001dgu.2	-	6	370	c.226G>T	c.(226-228)GGC>TGC	p.G76C	SLC44A5_uc001dgt.2_Missense_Mutation_p.G76C|SLC44A5_uc001dgs.2_Missense_Mutation_p.G34C|SLC44A5_uc001dgr.2_Missense_Mutation_p.G34C|SLC44A5_uc010oqz.1_Missense_Mutation_p.G115C|SLC44A5_uc010ora.1_Missense_Mutation_p.G70C|SLC44A5_uc010orb.1_Intron	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	76	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						CAAAAGTGGCCCTGGCTGTCT	0.478			NA											10	6					4.68919e-08	5.93141e-08	0.008291	1	0
AK5	26289	broad.mit.edu	37	1	77876672	77876672	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:77876672G>C	uc001dhn.2	+	7	1155	c.898G>C	c.(898-900)GCC>CCC	p.A300P	AK5_uc001dho.2_Missense_Mutation_p.A274P	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1	300					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						CCAGTTTGATGCCGACCGCGA	0.418			NA											3	32					0	0	0.009096	0	0
GBP6	163351	broad.mit.edu	37	1	89834176	89834176	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:89834176G>T	uc001dnf.2	+	2	340	c.66G>T	c.(64-66)TTG>TTT	p.L22F	GBP6_uc010ost.1_Intron	NM_198460	NP_940862	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	22							GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		AGCAGCTATTGGTGAACCAGC	0.478			NA											19	52					8.10497e-08	1.01718e-07	0.010504	1	0
ZNF644	84146	broad.mit.edu	37	1	91403085	91403085	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:91403085C>A	uc001dnw.2	-	4	3787	c.3645G>T	c.(3643-3645)CCG>CCT	p.P1215P	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	1215					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		GATACATCAACGGACTATCCT	0.373			NA											22	52					2.39556e-15	3.71441e-15	0.00278	1	0
GLMN	11146	broad.mit.edu	37	1	92730115	92730115	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:92730115A>T	uc001dor.2	-	14	1410	c.1295T>A	c.(1294-1296)TTA>TAA	p.L432*	GLMN_uc009wdg.2_Intron|GLMN_uc001dos.2_Nonsense_Mutation_p.L418*	NM_053274	NP_444504	Q92990	GLMN_HUMAN	glomulin	432					muscle cell differentiation|negative regulation of T cell proliferation|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of phosphorylation|regulation of gene expression, epigenetic|vasculogenesis	intracellular	hepatocyte growth factor receptor binding			skin(1)	1		all_lung(203;0.00827)|Lung NSC(277;0.0295)		all cancers(265;0.00702)|GBM - Glioblastoma multiforme(16;0.0381)|Epithelial(280;0.0989)		TCTTACCTTTAATGACATGTC	0.289			NA							Multiple_Glomus_Tumors_(of_the_Skin)_Familial				6	25					0	0	0.001168	0	0
PTBP2	58155	broad.mit.edu	37	1	97243152	97243152	+	Silent	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:97243152A>G	uc001drq.2	+	6	690	c.444A>G	c.(442-444)GCA>GCG	p.A148A	PTBP2_uc001drn.2_Silent_p.A148A|PTBP2_uc001dro.2_Silent_p.A148A|PTBP2_uc010otz.1_Silent_p.A159A|PTBP2_uc001drp.2_RNA|PTBP2_uc009wdw.2_Silent_p.A96A|PTBP2_uc001drr.2_Silent_p.A148A|PTBP2_uc010oua.1_Silent_p.A156A|PTBP2_uc001dru.2_RNA	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	148							nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		GTGCTCAGGCAGTTCTTCAAG	0.438			NA											16	21					0	0	0.006122	0	0
LPPR5	163404	broad.mit.edu	37	1	99470069	99470069	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:99470069G>T	uc001dsb.2	-	1	381	c.159C>A	c.(157-159)CCC>CCA	p.P53P	uc001dsd.1_RNA|LPPR5_uc001dsc.2_Silent_p.P53P	NM_001037317	NP_001032394	Q32ZL2	LPPR5_HUMAN	phosphatidic acid phosphatase type 2d isoform 1	53						integral to membrane	hydrolase activity				0						GGCCCGGGTAGGGTTTGCGGT	0.687			NA											7	23					5.18039e-06	6.06341e-06	0.00308	1	0
LPPR4	9890	broad.mit.edu	37	1	99772228	99772228	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:99772228C>A	uc001dse.2	+	7	2060	c.1954C>A	c.(1954-1956)CCT>ACT	p.P652T	LPPR4_uc010oue.1_Missense_Mutation_p.P594T	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	652							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		GTGGAAAGCCCCTGAAAAGGG	0.532			NA											7	16					5.18039e-06	6.06341e-06	0.00308	1	0
FRRS1	391059	broad.mit.edu	37	1	100181217	100181217	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:100181217C>A	uc001dsh.1	-	12	1850	c.1248G>T	c.(1246-1248)ATG>ATT	p.M416I		NM_001013660	NP_001013682	Q6ZNA5	FRRS1_HUMAN	stromal cell derived factor receptor 2 homolog	416	Cytochrome b561.|Helical; Name=3; (Potential).				electron transport chain|transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.09e-06)|all_lung(203;0.000435)|Lung NSC(277;0.00201)		Epithelial(280;0.0718)|all cancers(265;0.126)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.206)		TGAACATGAGCATCCGATGCA	0.418			NA											14	34					0.000151284	0.000168068	0.001855	1	0
S1PR1	1901	broad.mit.edu	37	1	101705131	101705131	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:101705131C>A	uc001dud.2	+	2	1105	c.591C>A	c.(589-591)CTC>CTA	p.L197L	S1PR1_uc009weg.2_Silent_p.L197L	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	197	Extracellular (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						TGCTGCCGCTCTACCACAAGC	0.567			NA									OREG0013620	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	50					6.31663e-08	7.96204e-08	0.003163	1	0
MAGI3	260425	broad.mit.edu	37	1	114226374	114226374	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:114226374C>G	uc001edk.2	+	21	4365	c.4184C>G	c.(4183-4185)TCT>TGT	p.S1395C	MAGI3_uc001edi.3_3'UTR|MAGI3_uc010owm.1_3'UTR|MAGI3_uc001edj.2_3'UTR|MAGI3_uc009wgo.2_RNA	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	1420					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAAACAAGTTCTAGTAACGAT	0.343			NA											5	5					0	0	0.000602	0	0
ATP1A1	476	broad.mit.edu	37	1	116935553	116935553	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:116935553G>A	uc001ege.2	+	11	1749	c.1410G>A	c.(1408-1410)ATG>ATA	p.M470I	ATP1A1_uc010owv.1_Missense_Mutation_p.M439I|ATP1A1_uc010oww.1_Missense_Mutation_p.M470I|ATP1A1_uc010owx.1_Missense_Mutation_p.M439I|C1orf203_uc009whb.2_RNA	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	470	Cytoplasmic (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	TGAAGGAGATGAGAGAAAGAT	0.522			NA											12	73					0	0	0.001368	0	0
ZNF697	90874	broad.mit.edu	37	1	120165431	120165431	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:120165431C>T	uc001ehy.1	-	3	1649	c.1535G>A	c.(1534-1536)CGC>CAC	p.R512H		NM_001080470	NP_001073939	Q5TEC3	ZN697_HUMAN	zinc finger protein 697	512	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0266)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0577)		GTGGATGCGGCGGTGGCGGAT	0.632			NA											8	9					0	0	0.004482	0	0
ITGA10	8515	broad.mit.edu	37	1	145531018	145531018	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:145531018G>T	uc001eoa.2	+	7	826	c.750G>T	c.(748-750)ATG>ATT	p.M250I	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Missense_Mutation_p.M119I|ITGA10_uc009wiw.2_Missense_Mutation_p.M107I|ITGA10_uc010oyw.1_Missense_Mutation_p.M195I	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	250	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AAGCAATAATGGTGGCCTGGT	0.473			NA											22	24					2.32416e-17	3.75721e-17	0.002299	1	0
ITGA10	8515	broad.mit.edu	37	1	145532463	145532463	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:145532463G>T	uc001eoa.2	+	9	992	c.916G>T	c.(916-918)GGT>TGT	p.G306C	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Missense_Mutation_p.G175C|ITGA10_uc009wiw.2_Missense_Mutation_p.G163C|ITGA10_uc010oyw.1_Missense_Mutation_p.G251C	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	306	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTAGGTCCTTGGTCACTACCT	0.458			NA											16	49					3.32936e-07	4.06514e-07	0.006122	1	0
NUDT17	200035	broad.mit.edu	37	1	145586916	145586916	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:145586916C>T	uc001eoe.2	-	7	780	c.772G>A	c.(772-774)GTC>ATC	p.V258I	NBPF10_uc001emp.3_Intron	NM_001012758	NP_001012776	P0C025	NUD17_HUMAN	nudix (nucleoside diphosphate linked moiety	258							hydrolase activity|metal ion binding				0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ATGTGCAGGACCAGAGGTCGG	0.478			NA											52	68					0	0	0.00361	0	0
OTUD7B	56957	broad.mit.edu	37	1	149921592	149921592	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:149921592C>G	uc001etn.2	-	9	1419	c.1063G>C	c.(1063-1065)GAT>CAT	p.D355H		NM_020205	NP_064590	Q6GQQ9	OTU7B_HUMAN	zinc finger protein Cezanne	355	Catalytic.|OTU.|TRAF-binding.				negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			TGGGCCTGATCATAGGCGAGC	0.517			NA											17	56					0	0	0.008871	0	0
C1orf54	79630	broad.mit.edu	37	1	150249030	150249030	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:150249030C>G	uc001eud.2	+	4	328	c.290C>G	c.(289-291)ACA>AGA	p.T97R	C1orf54_uc001euc.2_Missense_Mutation_p.T97R|C1orf54_uc001eue.2_Missense_Mutation_p.T97R|C1orf54_uc001euf.2_Missense_Mutation_p.T97R|C1orf54_uc001eug.2_Missense_Mutation_p.T97R	NM_024579	NP_078855	Q8WWF1	CA054_HUMAN	hypothetical protein LOC79630 precursor	97						extracellular region					0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			AAACCAGTAACAACGGAACCT	0.493			NA											23	44					0	0	0.00278	0	0
ARNT	405	broad.mit.edu	37	1	150789613	150789613	+	Silent	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:150789613T>C	uc001evr.1	-	17	1787	c.1644A>G	c.(1642-1644)TTA>TTG	p.L548L	ARNT_uc010pck.1_Silent_p.L37L|ARNT_uc001evs.1_Silent_p.L533L|ARNT_uc009wmb.1_Silent_p.L534L|ARNT_uc009wmc.1_Silent_p.L548L|ARNT_uc009wmd.1_Silent_p.L533L	NM_001668	NP_001659	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	548					positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			skin(4)|lung(3)|central_nervous_system(1)|kidney(1)	9	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCTGGGCAAATAAACCATCTG	0.383			NA	T	ETV6	AML								14	42					0	0	0.004007	0	0
ARNT	405	broad.mit.edu	37	1	150811989	150811989	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:150811989G>A	uc001evr.1	-	6	557	c.414C>T	c.(412-414)CAC>CAT	p.H138H	ARNT_uc001evs.1_Silent_p.H123H|ARNT_uc009wmb.1_Silent_p.H129H|ARNT_uc009wmc.1_Silent_p.H138H|ARNT_uc009wmd.1_Silent_p.H123H|ARNT_uc009wme.1_Silent_p.H138H|ARNT_uc010pcl.1_Silent_p.H122H	NM_001668	NP_001659	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	138	Helix-loop-helix motif.				positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			skin(4)|lung(3)|central_nervous_system(1)|kidney(1)	9	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGGACTTCATGTGAGAAACTG	0.498			NA	T	ETV6	AML								55	69					0	0	0.00361	0	0
CELF3	11189	broad.mit.edu	37	1	151682231	151682231	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:151682231C>T	uc001eys.1	-	3	1059	c.265G>A	c.(265-267)GAG>AAG	p.E89K	CELF3_uc010pdh.1_5'Flank|CELF3_uc001eyr.2_Missense_Mutation_p.E89K|CELF3_uc009wmy.2_Missense_Mutation_p.E89K|CELF3_uc009wmx.1_Missense_Mutation_p.E89K|CELF3_uc001eyt.2_Missense_Mutation_p.E13K|CELF3_uc010pdi.1_Missense_Mutation_p.E89K|C1orf230_uc001eyu.2_5'Flank	NM_007185	NP_009116	Q5SZQ8	CELF3_HUMAN	trinucleotide repeat containing 4	89					nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			ovary(1)|central_nervous_system(1)	2						CCTCGGCTCTCGCTGTCGGCT	0.622			NA											11	60					0	0	0.008871	0	0
RPTN	126638	broad.mit.edu	37	1	152127334	152127334	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:152127334G>T	uc001ezs.1	-	3	2306	c.2241C>A	c.(2239-2241)ACC>ACA	p.T747T		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	747	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						CATGTTCATGGGTTTGTCTGT	0.522			NA											144	218					1.18608e-55	2.28043e-55	0.00361	1	0
HRNR	388697	broad.mit.edu	37	1	152191918	152191918	+	Missense_Mutation	SNP	G	G	T	rs146453724	byFrequency	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:152191918G>T	uc001ezt.1	-	3	2263	c.2187C>A	c.(2185-2187)CAC>CAA	p.H729Q		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	729	7.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCTAGAGCCGTGTTTTCTGT	0.537			NA											95	161					3.07327e-39	5.85424e-39	0.00361	1	0
FLG	2312	broad.mit.edu	37	1	152280800	152280800	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:152280800T>A	uc001ezu.1	-	3	6598	c.6562A>T	c.(6562-6564)AGT>TGT	p.S2188C		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2188	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGCTTGCACTTCTGGATCCT	0.532			NA							Ichthyosis				63	450					0	0	0.00361	0	0
FLG	2312	broad.mit.edu	37	1	152283963	152283963	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:152283963C>T	uc001ezu.1	-	3	3435	c.3399G>A	c.(3397-3399)CGG>CGA	p.R1133R	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1133	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGTCCTGGTCCGCCCATGGG	0.592			NA							Ichthyosis				105	236					0	0	0.00361	0	0
FLG	2312	broad.mit.edu	37	1	152287816	152287816	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:152287816C>G	uc001ezu.1	-	2	153	c.117G>C	c.(115-117)AAG>AAC	p.K39N	uc001ezv.2_Intron	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	39	EF-hand 1.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity	p.K39N(1)		ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCGAAATTCCTTTTCCAGAA	0.328			NA							Ichthyosis				28	144					0	0	0.003755	0	0
FLG2	388698	broad.mit.edu	37	1	152327631	152327631	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:152327631G>A	uc001ezw.3	-	3	2704	c.2631C>T	c.(2629-2631)AGC>AGT	p.S877S	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	877	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATTGACCTGAGCTTGACCTGT	0.502			NA											183	273					0	0	0.00361	0	0
KPRP	448834	broad.mit.edu	37	1	152733784	152733784	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:152733784G>A	uc001fal.1	+	2	1778	c.1720G>A	c.(1720-1722)GCA>ACA	p.A574T		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	574						cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAAAGGGGAAGCAAAGAGTGC	0.502			NA											8	34					0	0	0.00308	0	0
LCE1A	353131	broad.mit.edu	37	1	152799984	152799984	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:152799984C>A	uc010pdw.1	+	1	36	c.36C>A	c.(34-36)CCC>CCA	p.P12P		NM_178348	NP_848125	Q5T7P2	LCE1A_HUMAN	late cornified envelope 1A	12	Cys-rich.				keratinization					ovary(1)|skin(1)	2	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGTGCCAGCCCCCTcccaagt	0.383			NA											21	53					1.87028e-06	2.22704e-06	0.001882	1	0
ILF2	3608	broad.mit.edu	37	1	153635230	153635230	+	Silent	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:153635230G>C	uc001fcr.2	-	13	1044	c.963C>G	c.(961-963)CTC>CTG	p.L321L	ILF2_uc010pdy.1_Silent_p.L283L|ILF2_uc009wok.2_Silent_p.L299L	NM_004515	NP_004506	Q12905	ILF2_HUMAN	interleukin enhancer binding factor 2	321	DZF.				immune response|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|ribonucleoprotein complex	ATP binding|DNA binding|double-stranded RNA binding|protein binding|transferase activity				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			CACCATGTGAGAGGATTCGGA	0.468			NA											25	95					0	0	0.004656	0	0
DCST1	149095	broad.mit.edu	37	1	155006533	155006533	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:155006533G>A	uc001fgn.1	+	2	117	c.21G>A	c.(19-21)CAG>CAA	p.Q7Q	DCST2_uc001fgm.2_5'Flank|DCST2_uc009wpb.2_5'Flank|DCST1_uc010per.1_5'UTR|DCST1_uc010pes.1_Silent_p.Q7Q	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	7	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			AACATCATCAGAATGGCACAA	0.502			NA											9	51					0	0	0.008291	0	0
ADAM15	8751	broad.mit.edu	37	1	155030771	155030771	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:155030771C>G	uc001fgr.1	+	15	1872	c.1771C>G	c.(1771-1773)CTG>GTG	p.L591V	ADAM15_uc001fgq.1_Missense_Mutation_p.L276V|ADAM15_uc010pet.1_Missense_Mutation_p.L575V|ADAM15_uc010peu.1_Missense_Mutation_p.L608V|ADAM15_uc001fgt.1_Missense_Mutation_p.L591V|ADAM15_uc010pev.1_Missense_Mutation_p.L601V|ADAM15_uc001fgs.1_Missense_Mutation_p.L591V|ADAM15_uc001fgu.1_Missense_Mutation_p.L591V|ADAM15_uc001fgw.1_Missense_Mutation_p.L591V|ADAM15_uc001fgv.1_Missense_Mutation_p.L591V|ADAM15_uc001fgx.1_Missense_Mutation_p.L591V|ADAM15_uc001fgz.1_RNA|ADAM15_uc001fgy.1_RNA|ADAM15_uc001fha.1_RNA|ADAM15_uc001fhb.1_5'UTR	NM_207197	NP_997080	Q13444	ADA15_HUMAN	a disintegrin and metalloproteinase domain 15	591	Extracellular (Potential).|Cys-rich.				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			central_nervous_system(3)|skin(2)|ovary(1)	6	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GACCCAGCCTCTGCTGGGCTC	0.597			NA											5	48					0	0	0.001168	0	0
OR10K1	391109	broad.mit.edu	37	1	158435542	158435542	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:158435542C>A	uc010pij.1	+	1	191	c.191C>A	c.(190-192)GCC>GAC	p.A64D		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TTCTTCCTTGCCATCCTTTCT	0.478			NA											22	84					7.33532e-06	8.53715e-06	0.003954	1	0
OR10Z1	128368	broad.mit.edu	37	1	158576318	158576318	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:158576318G>C	uc010pio.1	+	1	90	c.90G>C	c.(88-90)TTG>TTC	p.L30F		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					TCTTTGCCTTGTTCCTCTCTC	0.502			NA											36	73					0	0	0.003755	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576491	158576491	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:158576491G>T	uc010pio.1	+	1	263	c.263G>T	c.(262-264)GGG>GTG	p.G88V		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	88	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					CTGGCTGGGGGGGACCAGGCT	0.552			NA											56	113					2.76378e-25	5.03204e-25	0.00361	1	0
SPTA1	6708	broad.mit.edu	37	1	158613134	158613134	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:158613134G>T	uc001fst.1	-	31	4619	c.4420C>A	c.(4420-4422)CGG>AGG	p.R1474R		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1474	Spectrin 14.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CGTTGGAGCCGCGTAGCAATC	0.438			NA											10	29					2.17888e-05	2.49757e-05	0.006214	1	0
SPTA1	6708	broad.mit.edu	37	1	158639227	158639227	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:158639227T>C	uc001fst.1	-	14	2003	c.1804A>G	c.(1804-1806)AAA>GAA	p.K602E		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	602	Spectrin 7.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GCCAACTTTTTCTTCTTGTTG	0.388			NA											32	218					0	0	0.003271	0	0
OR10J3	441911	broad.mit.edu	37	1	159284388	159284388	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:159284388C>A	uc010piu.1	-	1	62	c.62G>T	c.(61-63)AGG>ATG	p.R21M		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					GTGCTGCCGCCTGAAGCTGGA	0.448			NA											48	102					1.21353e-23	2.17381e-23	0.00361	1	0
FCRL6	343413	broad.mit.edu	37	1	159778918	159778918	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:159778918C>A	uc001fud.3	+	4	529	c.487C>A	c.(487-489)CCA>ACA	p.P163T	FCRL6_uc010pix.1_3'UTR|FCRL6_uc001fuc.2_Missense_Mutation_p.P170T|FCRL6_uc009wsz.1_Intron|FCRL6_uc009wta.2_Missense_Mutation_p.P163T	NM_001004310	NP_001004310	Q6DN72	FCRL6_HUMAN	Fc receptor-like 6 precursor	163	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	all_hematologic(112;0.0597)					GGGCCCTCACCCAGAACTCTG	0.622			NA											7	47					1.76689e-08	2.25874e-08	0.006214	1	0
CCDC19	25790	broad.mit.edu	37	1	159850393	159850393	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:159850393T>A	uc001fui.2	-	8	1013	c.995A>T	c.(994-996)CAG>CTG	p.Q332L	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Missense_Mutation_p.Q247L|CCDC19_uc001ful.2_Missense_Mutation_p.Q247L|CCDC19_uc009wtc.1_Missense_Mutation_p.Q318L	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	332	Potential.					mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			CAGCTTCTCCTGAGCCAGCAG	0.463			NA											49	54					0	0	0.00361	0	0
SLAMF1	6504	broad.mit.edu	37	1	160616732	160616732	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:160616732C>A	uc001fwl.3	-	1	350	c.4G>T	c.(4-6)GAT>TAT	p.D2Y	SLAMF1_uc010pjk.1_RNA|SLAMF1_uc010pjl.1_RNA|SLAMF1_uc010pjm.1_RNA|SLAMF1_uc001fwm.2_Missense_Mutation_p.D2Y	NM_003037	NP_003028	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family	2					interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			ovary(1)|breast(1)	2	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CCCTTGGGATCCATCAGCCAA	0.567			NA											4	16					0.00024832	0.00027355	0.009096	1	0
CD244	51744	broad.mit.edu	37	1	160811650	160811650	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:160811650C>A	uc009wtq.2	-	2	281	c.103G>T	c.(103-105)GTG>TTG	p.V35L	CD244_uc001fxa.2_Missense_Mutation_p.V35L|CD244_uc009wtp.2_RNA|CD244_uc009wtr.2_Missense_Mutation_p.V35L|CD244_uc010pjt.1_RNA	NM_016382	NP_057466	Q9BZW8	CD244_HUMAN	CD244 natural killer cell receptor 2B4	35	Extracellular (Potential).|Ig-like 1.				blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TGAAGAGGCACTCCCGAGATG	0.483			NA											21	26					1.55469e-16	2.47174e-16	0.00333	1	0
ARHGAP30	257106	broad.mit.edu	37	1	161024251	161024251	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:161024251G>A	uc001fxl.2	-	5	787	c.441C>T	c.(439-441)TTC>TTT	p.F147F	ARHGAP30_uc001fxk.2_Silent_p.F147F|ARHGAP30_uc001fxm.2_5'UTR|ARHGAP30_uc009wtx.2_5'UTR|ARHGAP30_uc001fxn.1_5'UTR	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	147	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GCCTCATGAGGAACTCCAGGG	0.602			NA											3	17					0	0	0.004672	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161024438	161024438	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:161024438G>A	uc001fxl.2	-	4	749	c.403C>T	c.(403-405)CGG>TGG	p.R135W	ARHGAP30_uc001fxk.2_Missense_Mutation_p.R135W|ARHGAP30_uc001fxm.2_5'UTR|ARHGAP30_uc009wtx.2_5'UTR|ARHGAP30_uc001fxn.1_5'UTR	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	135	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GGGAGTTCCCGAAGCACCTCT	0.527			NA											20	68					0	0	0.008871	0	0
ADAMTS4	9507	broad.mit.edu	37	1	161163073	161163073	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:161163073G>T	uc001fyt.3	-	7	2269	c.1841C>A	c.(1840-1842)GCC>GAC	p.A614D		NM_005099	NP_005090	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1	614	Cys-rich.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			ovary(4)|central_nervous_system(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GTCCTGGGGGGCCACGCCTGT	0.647			NA											9	31					0.000274275	0.000300993	0.004482	1	0
FCGR2B	2213	broad.mit.edu	37	1	161645088	161645088	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:161645088C>A	uc001gaz.1	+	6	894	c.802C>A	c.(802-804)CTC>ATC	p.L268I	FCGR2B_uc001gay.1_Missense_Mutation_p.L267I|FCGR2B_uc001gba.1_Intron|FCGR2B_uc001gbb.1_Intron|FCGR2B_uc009wun.1_Missense_Mutation_p.L261I	NM_004001	NP_003992	P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor	268	Cytoplasmic (Potential).				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GGGAGAGACCCTCCCTGAGAA	0.602			NA	T	?	ALL								6	14					2.7689e-08	3.53028e-08	0.001984	1	0
OLFML2B	25903	broad.mit.edu	37	1	161989783	161989783	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:161989783G>T	uc001gbu.2	-	2	788	c.364C>A	c.(364-366)CCA>ACA	p.P122T	OLFML2B_uc010pkq.1_Missense_Mutation_p.P122T	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	122										skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			AGGGCCGATGGGGGTGCTACA	0.597			NA											18	41					2.94398e-08	3.74689e-08	0.007413	1	0
DUSP27	92235	broad.mit.edu	37	1	167097504	167097504	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:167097504C>A	uc001geb.1	+	5	3136	c.3136C>A	c.(3136-3138)CCA>ACA	p.P1046T		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	1046					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						CCGCCGGACCCCAGAGTCCTC	0.577			NA											13	26					1.5842e-08	2.03602e-08	0.001855	1	0
F5	2153	broad.mit.edu	37	1	169492497	169492497	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:169492497C>A	uc001ggg.1	-	21	6131	c.5986G>T	c.(5986-5988)GCT>TCT	p.A1996S		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1996	F5/8 type C 1.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GAACTGTAAGCTACATAGAAC	0.438			NA											42	39					2.64894e-19	4.45715e-19	0.00361	1	0
F5	2153	broad.mit.edu	37	1	169529962	169529962	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:169529962T>A	uc001ggg.1	-	4	561	c.416A>T	c.(415-417)GAC>GTC	p.D139V	F5_uc010plr.1_RNA	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	139	F5/8 type A 1.|Plastocyanin-like 1.	Calcium (By similarity).			cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CACAGCGTCGTCCATCTTCTC	0.522			NA											26	45					0	0	0.005443	0	0
SELP	6403	broad.mit.edu	37	1	169582879	169582879	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:169582879G>T	uc001ggi.3	-	4	599	c.534C>A	c.(532-534)ATC>ATA	p.I178I	SELP_uc001ggh.2_Silent_p.I13I|SELP_uc009wvr.2_Silent_p.I178I	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	178	Extracellular (Potential).|EGF-like.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	TGTAGTTCCCGATGGTCTCGA	0.473			NA											19	44					2.37509e-13	3.5127e-13	0.010504	1	0
C1orf112	55732	broad.mit.edu	37	1	169812836	169812836	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:169812836C>T	uc001ggp.2	+	20	2180	c.1870C>T	c.(1870-1872)CAA>TAA	p.Q624*	C1orf112_uc001ggj.2_RNA|C1orf112_uc001ggq.2_Nonsense_Mutation_p.Q624*|C1orf112_uc009wvt.2_Nonsense_Mutation_p.Q301*|C1orf112_uc009wvu.1_Nonsense_Mutation_p.Q500*|C1orf112_uc001ggr.2_Nonsense_Mutation_p.Q489*|C1orf112_uc010plv.1_Nonsense_Mutation_p.Q566*	NM_018186	NP_060656	Q9NSG2	CA112_HUMAN	hypothetical protein LOC55732	624											0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ACCTTATGTTCAACAGACATT	0.274			NA											6	42					0	0	0.00308	0	0
C1orf9	51430	broad.mit.edu	37	1	172539803	172539803	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:172539803A>T	uc001giq.3	+	9	1298	c.982A>T	c.(982-984)AGC>TGC	p.S328C	C1orf9_uc010pmm.1_Missense_Mutation_p.S328C|C1orf9_uc009wwd.2_Missense_Mutation_p.S291C|C1orf9_uc010pmn.1_Missense_Mutation_p.S291C|C1orf9_uc010pmo.1_RNA	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	328	SUN.				multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		TTTAAAATAGAGCACATCTGC	0.269	Colon(43;174 953 11768 38880 47057)		NA											16	30					0	0	0.00499	0	0
C1orf9	51430	broad.mit.edu	37	1	172579351	172579351	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:172579351G>T	uc001giq.3	+	24	4033	c.3717G>T	c.(3715-3717)GAG>GAT	p.E1239D	C1orf9_uc009wwd.2_Missense_Mutation_p.E1195D|C1orf9_uc010pmn.1_Missense_Mutation_p.E868D|C1orf9_uc010pmo.1_RNA	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	1239					multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		GAAACAAAGAGATCACCGTGG	0.368	Colon(43;174 953 11768 38880 47057)		NA											15	34					4.14922e-12	5.89475e-12	0.004007	1	0
TNN	63923	broad.mit.edu	37	1	175046639	175046639	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:175046639G>T	uc001gkl.1	+	2	198	c.85G>T	c.(85-87)GAG>TAG	p.E29*	TNN_uc010pmx.1_Nonsense_Mutation_p.E29*	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	29					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGCCACTCTGGAGCCTCCCGG	0.597			NA											8	19					9.95505e-16	1.55696e-15	0.002299	1	0
LAMC2	3918	broad.mit.edu	37	1	183189969	183189969	+	Silent	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:183189969A>G	uc001gqa.2	+	5	827	c.513A>G	c.(511-513)TCA>TCG	p.S171S	LAMC2_uc001gpz.3_Silent_p.S171S|LAMC2_uc010poa.1_5'UTR	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	171	Laminin EGF-like 3.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						GGTGTCGATCAGGTTACTATA	0.448			NA											7	29					0	0	0.004482	0	0
NMNAT2	23057	broad.mit.edu	37	1	183230436	183230436	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:183230436C>T	uc001gqc.1	-	9	989	c.654G>A	c.(652-654)ATG>ATA	p.M218I	NMNAT2_uc009wye.1_RNA|NMNAT2_uc001gqb.1_Missense_Mutation_p.M213I	NM_015039	NP_055854	Q9BZQ4	NMNA2_HUMAN	nicotinamide mononucleotide adenylyltransferase	218					water-soluble vitamin metabolic process	Golgi membrane|nucleus	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity			skin(1)	1						CAATCACCTCCATCTAAAGAA	0.493			NA											23	19					0	0	0.00278	0	0
NCF2	4688	broad.mit.edu	37	1	183546792	183546792	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:183546792C>A	uc001gqj.3	-	3	583	c.308G>T	c.(307-309)GGG>GTG	p.G103V	NCF2_uc010pod.1_Missense_Mutation_p.G103V|NCF2_uc010poe.1_Missense_Mutation_p.G103V|NCF2_uc001gqk.3_Missense_Mutation_p.G103V	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	103	TPR 2.				cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						CAGCTGGTTCCCTCGAAGCTG	0.488			NA											12	70					4.36969e-10	5.83435e-10	0.001855	1	0
NCF2	4688	broad.mit.edu	37	1	183546814	183546814	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:183546814C>T	uc001gqj.3	-	3	561	c.286G>A	c.(286-288)GAA>AAA	p.E96K	NCF2_uc010pod.1_Missense_Mutation_p.E96K|NCF2_uc010poe.1_Missense_Mutation_p.E96K|NCF2_uc001gqk.3_Missense_Mutation_p.E96K	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	96	TPR 2.		Missing (in CGD2).		cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						ATCAAGGCTTCTTTAAGGTCT	0.458			NA											11	60					0	0	0.000978	0	0
FAM129A	116496	broad.mit.edu	37	1	184764460	184764460	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:184764460C>A	uc001gra.2	-	14	2632	c.2438G>T	c.(2437-2439)GGG>GTG	p.G813V	FAM129A_uc001grb.1_Intron	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	813	Glu-rich.				negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						TGGGAGCTCCCCCTCCATGGG	0.657			NA											23	59					4.87955e-14	7.3295e-14	0.005443	1	0
RNF2	6045	broad.mit.edu	37	1	185068982	185068982	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:185068982G>A	uc001grc.1	+	6	1030	c.797G>A	c.(796-798)AGG>AAG	p.R266K	RNF2_uc001grd.1_Missense_Mutation_p.R194K|RNF2_uc001gre.1_RNA	NM_007212	NP_009143	Q99496	RING2_HUMAN	ring finger protein 2	266					histone H2A monoubiquitination|transcription, DNA-dependent	MLL1 complex|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			breast(1)	1		Breast(1374;0.000496)		Colorectal(1306;6.9e-08)|KIRC - Kidney renal clear cell carcinoma(1967;8.12e-06)		CTGGCTGTGAGGTTAGCTTTA	0.363			NA											19	53					0	0	0.010504	0	0
C1orf25	81627	broad.mit.edu	37	1	185089601	185089601	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:185089601C>A	uc001grf.3	-	14	2135	c.1863G>T	c.(1861-1863)AAG>AAT	p.K621N	C1orf25_uc010pon.1_Missense_Mutation_p.K465N	NM_030934	NP_112196	Q7Z2T5	TRM1L_HUMAN	N2,N2-dimethylguanosine tRNA	621						intracellular	RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding				0						TCTTTTGCTTCTTGCCTAAAT	0.338			NA											13	39					0.00010058	0.000112257	0.001368	1	0
HMCN1	83872	broad.mit.edu	37	1	185931747	185931747	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:185931747G>C	uc001grq.1	+	12	2155	c.1926G>C	c.(1924-1926)AAG>AAC	p.K642N	HMCN1_uc001grr.1_5'UTR	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	642	Ig-like C2-type 3.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CCAAACCAAAGATTGCCTGGA	0.428			NA											14	93					0	0	0.00499	0	0
PRG4	10216	broad.mit.edu	37	1	186276708	186276708	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:186276708C>A	uc001gru.3	+	7	1908	c.1857C>A	c.(1855-1857)ACC>ACA	p.T619T	PRG4_uc001grt.3_Silent_p.T578T|PRG4_uc009wyl.2_Silent_p.T526T|PRG4_uc009wym.2_Silent_p.T485T|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	619	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|35; approximate.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CTGCACCCACCACCCCCAAGA	0.667			NA											26	22					0.000147802	0.000164706	0.00632	1	0
PRG4	10216	broad.mit.edu	37	1	186277469	186277469	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:186277469C>A	uc001gru.3	+	7	2669	c.2618C>A	c.(2617-2619)CCT>CAT	p.P873H	PRG4_uc001grt.3_Missense_Mutation_p.P832H|PRG4_uc009wyl.2_Missense_Mutation_p.P780H|PRG4_uc009wym.2_Missense_Mutation_p.P739H|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	873					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CACAAAAGCCCTGATGAATCA	0.502			NA											57	68					3.93605e-18	6.47183e-18	0.00361	1	0
TPR	7175	broad.mit.edu	37	1	186287706	186287706	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:186287706C>A	uc001grv.2	-	48	6991	c.6694G>T	c.(6694-6696)GAT>TAT	p.D2232Y		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	2232					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TCCGAAGCATCAGAGGTGGTG	0.383			NA	T	NTRK1	papillary thyroid								14	39					0.00185496	0.0019917	0.001855	1	0
FAM5C	339479	broad.mit.edu	37	1	190067745	190067745	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:190067745C>A	uc001gse.1	-	8	1936	c.1704G>T	c.(1702-1704)GTG>GTT	p.V568V	FAM5C_uc010pot.1_Silent_p.V466V	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	568						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					AAACAGCCAACACTGGCTCCA	0.453			NA											42	52					3.61848e-18	5.96325e-18	0.007835	1	0
PTPRC	5788	broad.mit.edu	37	1	198675957	198675957	+	Silent	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:198675957T>C	uc001gur.1	+	9	954	c.774T>C	c.(772-774)TGT>TGC	p.C258C	PTPRC_uc001gus.1_Silent_p.C210C|PTPRC_uc001gut.1_Silent_p.C97C|PTPRC_uc009wzf.1_Silent_p.C146C|PTPRC_uc010ppg.1_Silent_p.C194C	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	258	Extracellular (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						ATGTGGAATGTGGAAACAATA	0.313			NA											45	67					0	0	0.003214	0	0
NR5A2	2494	broad.mit.edu	37	1	200012940	200012940	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:200012940G>C	uc001gvb.2	+	3	447	c.241G>C	c.(241-243)GAT>CAT	p.D81H	NR5A2_uc001gvc.2_Missense_Mutation_p.D35H|NR5A2_uc009wzh.2_Missense_Mutation_p.D41H|NR5A2_uc010pph.1_Missense_Mutation_p.D9H	NM_205860	NP_995582	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	81					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Prostate(682;0.19)					CTATGATGAAGATCTGGAAGA	0.388	Melanoma(179;1138 2773 15678 26136)		NA											13	16					0	0	0.00245	0	0
RNPEP	6051	broad.mit.edu	37	1	201969078	201969078	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:201969078G>C	uc001gxd.2	+	6	1168	c.1139G>C	c.(1138-1140)CGT>CCT	p.R380P	RNPEP_uc001gxe.2_Missense_Mutation_p.R81P|RNPEP_uc001gxf.2_Missense_Mutation_p.R249P	NM_020216	NP_064601	Q9H4A4	AMPB_HUMAN	arginyl aminopeptidase	380					leukotriene biosynthetic process		epoxide hydrolase activity|zinc ion binding			upper_aerodigestive_tract(1)	1				KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.005)		GCTCTGCTGCGTCAGCACATG	0.582	GBM(19;39 479 7473 13131 19462)		NA									OREG0014093	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	25					0	0	0.000602	0	0
CHI3L1	1116	broad.mit.edu	37	1	203149636	203149637	+	Missense_Mutation	DNP	GG	GG	AT	rs138989209		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:203149636_203149637GG>AT	uc001gzi.2	-	8	1026_1027	c.855_856CC>AT	c.(853-858)GGCCGG>GGATGG	p.R286W	FMOD_uc010pqi.1_Intron|CHI3L1_uc001gzk.1_Intron|CHI3L1_uc001gzj.2_Intron|CHI3L1_uc001gzl.3_5'Flank	NM_001276	NP_001267	P36222	CH3L1_HUMAN	chitinase 3-like 1 precursor	286					chitin catabolic process	extracellular space|proteinaceous extracellular matrix	cation binding|chitinase activity|extracellular matrix structural constituent|sugar binding			pancreas(1)	1						TTGGTGAACCGGCCTGGAATTC	0.584			NA											13	24					0	0	0.004672	0	0
CR1L	1379	broad.mit.edu	37	1	207881565	207881565	+	Silent	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:207881565G>C	uc001hga.3	+	10	1492	c.1371G>C	c.(1369-1371)TCG>TCC	p.S457S	CR1L_uc001hfz.2_Intron|CR1L_uc001hgb.1_Intron	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	457	Sushi 7.					cytoplasm|extracellular region|membrane					0						GTATCCTCTCGGGCAATACTG	0.323			NA											24	126					0	0	0.004656	0	0
RPS6KC1	26750	broad.mit.edu	37	1	213415634	213415634	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:213415634G>C	uc010ptr.1	+	11	2974	c.2815G>C	c.(2815-2817)GAT>CAT	p.D939H	RPS6KC1_uc001hkd.2_Missense_Mutation_p.D927H|RPS6KC1_uc010pts.1_Missense_Mutation_p.D727H|RPS6KC1_uc010ptt.1_Missense_Mutation_p.D727H|RPS6KC1_uc010ptu.1_Missense_Mutation_p.D758H|RPS6KC1_uc010ptv.1_Missense_Mutation_p.D474H|RPS6KC1_uc001hke.2_Missense_Mutation_p.D758H	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	939	Protein kinase 2.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		CTTATTGAATGATAGAGGTCA	0.388			NA											31	82					0	0	0.003755	0	0
PROX1	5629	broad.mit.edu	37	1	214170420	214170420	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:214170420G>T	uc001hkh.2	+	2	814	c.542G>T	c.(541-543)AGT>ATT	p.S181I	PROX1_uc001hkg.1_Missense_Mutation_p.S181I	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	181					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		CATTCCCCCAGTGTGGCATTA	0.493			NA											26	33					4.87955e-14	7.3295e-14	0.005443	1	0
CENPF	1063	broad.mit.edu	37	1	214836933	214836933	+	Splice_Site	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:214836933G>T	uc001hkm.2	+	20	9316	c.9142_splice	c.e20-1	p.V3048_splice		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F						cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TTGTGTTGCAGGTCAAAGTTG	0.423	Colon(80;575 1284 11000 14801 43496)		NA											15	15					2.35188e-11	3.27673e-11	0.006122	1	0
USH2A	7399	broad.mit.edu	37	1	216591863	216591863	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:216591863C>A	uc001hku.1	-	3	1031	c.644G>T	c.(643-645)AGT>ATT	p.S215I	USH2A_uc001hkv.2_Missense_Mutation_p.S215I	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	215	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CACCTGCACACTAAGATGAAT	0.333			NA								HNSCC(13;0.011)			19	50					5.26018e-13	7.68508e-13	0.001882	1	0
DISP1	84976	broad.mit.edu	37	1	223178307	223178307	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:223178307G>C	uc001hnu.1	+	8	3715	c.3568G>C	c.(3568-3570)GAG>CAG	p.E1190Q		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1190					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		ACTGGAGCATGAGTTTTATGA	0.453			NA											31	32					0	0	0.008361	0	0
C1orf55	163859	broad.mit.edu	37	1	226175779	226175779	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:226175779C>A	uc001hpu.3	-	6	1005	c.952G>T	c.(952-954)GAG>TAG	p.E318*	C1orf55_uc001hpv.2_Nonsense_Mutation_p.E318*	NM_152608	NP_689821	Q6IQ49	CA055_HUMAN	hypothetical protein LOC163859	318										lung(1)	1	Breast(184;0.197)					TCCTGGGTCTCTTCTGTTTCT	0.498			NA											31	93					1.99505e-19	3.36475e-19	0.002445	1	0
C1orf95	375057	broad.mit.edu	37	1	226784513	226784513	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:226784513C>A	uc010pvn.1	+	2	318	c.213C>A	c.(211-213)GTC>GTA	p.V71V		NM_001003665	NP_001003665	Q69YW2	CA095_HUMAN	hypothetical protein LOC375057	71	Helical; (Potential).					integral to membrane				ovary(1)	1	Breast(184;0.133)	Prostate(94;0.0885)		GBM - Glioblastoma multiforme(131;0.113)		GGACATTCGTCTCGGCCTTCA	0.627			NA											23	76					2.41591e-17	3.8968e-17	0.004656	1	0
CDC42BPA	8476	broad.mit.edu	37	1	227504797	227504797	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:227504797C>A	uc001hqr.2	-	1	1030	c.87G>T	c.(85-87)GAG>GAT	p.E29D	CDC42BPA_uc001hqs.2_Missense_Mutation_p.E29D|CDC42BPA_uc009xes.2_Missense_Mutation_p.E29D|CDC42BPA_uc010pvs.1_Missense_Mutation_p.E29D	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	29					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				CCAGTAATGTCTCCACACTGA	0.438			NA											20	49					1.28384e-07	1.59183e-07	0.001882	1	0
WNT9A	7483	broad.mit.edu	37	1	228109639	228109639	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:228109639C>T	uc001hri.2	-	4	766	c.678G>A	c.(676-678)GTG>GTA	p.V226V		NM_003395	NP_003386	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family,	226					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			central_nervous_system(1)|pancreas(1)	2		Prostate(94;0.0405)				AGCAGGTCCGCACCGTGCATG	0.627			NA											9	54					0	0	0.004482	0	0
TRIM67	440730	broad.mit.edu	37	1	231344799	231344799	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:231344799C>T	uc009xfn.1	+	8	1968	c.1926C>T	c.(1924-1926)GGC>GGT	p.G642G		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	tripartite motif-containing 67	642	B30.2/SPRY.					cytoplasm|cytoskeleton	zinc ion binding			ovary(2)|breast(1)|kidney(1)	4	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				TGGTGCTGGGCACAGCTGCGT	0.617			NA											22	105					0	0	0.001882	0	0
NID1	4811	broad.mit.edu	37	1	236205413	236205413	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:236205413G>A	uc001hxo.2	-	4	1034	c.932C>T	c.(931-933)ACG>ATG	p.T311M	NID1_uc009xgd.2_Missense_Mutation_p.T311M	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	311					cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GGAGAAGGGCGTGGTGCCCAC	0.597			NA											65	54					0	0	0.00361	0	0
GPR137B	7107	broad.mit.edu	37	1	236306325	236306325	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:236306325T>A	uc001hxq.2	+	1	494	c.403T>A	c.(403-405)TAC>AAC	p.Y135N		NM_003272	NP_003263	O60478	G137B_HUMAN	G protein-coupled receptor 137B	135	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.197)|Prostate(94;0.219)|Acute lymphoblastic leukemia(190;0.226)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			GATGAACTTGTACTTCACGCA	0.647			NA											10	82					0	0	0.000978	0	0
RYR2	6262	broad.mit.edu	37	1	237947958	237947958	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:237947958G>T	uc001hyl.1	+	90	13066	c.12946G>T	c.(12946-12948)GGA>TGA	p.G4316*	RYR2_uc010pya.1_Nonsense_Mutation_p.G731*	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4316					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCTGCTTGGGGGAAGCCTCGT	0.507			NA											25	43					2.21704e-12	3.1779e-12	0.00278	1	0
FMN2	56776	broad.mit.edu	37	1	240370183	240370183	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:240370183G>A	uc010pyd.1	+	5	2296	c.2071G>A	c.(2071-2073)GCT>ACT	p.A691T	FMN2_uc010pye.1_Missense_Mutation_p.A695T	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	691	Potential.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AACCAAAATAGCTGAACTAGA	0.517			NA											23	45					0	0	0.00333	0	0
AHCTF1	25909	broad.mit.edu	37	1	247013073	247013073	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:247013073C>T	uc001ibu.1	-	32	6242	c.6235G>A	c.(6235-6237)GAG>AAG	p.E2079K	AHCTF1_uc001ibv.1_Missense_Mutation_p.E2088K|AHCTF1_uc009xgs.1_Missense_Mutation_p.E940K|AHCTF1_uc001ibw.1_RNA	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	2079	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TCTTCCTGCTCATTTGTTTCT	0.433	Colon(145;197 1800 4745 15099 26333)		NA											19	50					0	0	0.002299	0	0
ZNF496	84838	broad.mit.edu	37	1	247492105	247492105	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:247492105C>A	uc001ico.2	-	4	919	c.454G>T	c.(454-456)GAG>TAG	p.E152*	ZNF496_uc009xgv.2_Nonsense_Mutation_p.E152*|ZNF496_uc001icp.2_Nonsense_Mutation_p.E152*|ZNF496_uc010pyv.1_Nonsense_Mutation_p.E152*	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	152					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			GGCAGCTGCTCCTGCTCCTGG	0.597			NA											26	125					1.5548e-18	2.57113e-18	0.005443	1	0
OR2W5	441932	broad.mit.edu	37	1	247654766	247654766	+	Missense_Mutation	SNP	G	G	T	rs145704231		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:247654766G>T	uc001icz.1	+	1	337	c.337G>T	c.(337-339)GTC>TTC	p.V113F		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	113	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CACCGAGTGCGTCCTCCTGGT	0.602			NA											56	46					1.74971e-23	3.1265e-23	0.00361	1	0
OR2G3	81469	broad.mit.edu	37	1	247769203	247769203	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:247769203G>T	uc010pyz.1	+	1	316	c.316G>T	c.(316-318)GCA>TCA	p.A106S		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	106	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TATTTCTCTGGCACTGGGCTC	0.488			NA											51	156					1.54886e-18	2.57113e-18	0.00361	1	0
OR2L8	391190	broad.mit.edu	37	1	248112897	248112897	+	Silent	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:248112897A>T	uc001idt.1	+	1	738	c.738A>T	c.(736-738)GTA>GTT	p.V246V	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			ACCTCACTGTAGTAACTTTCT	0.468			NA											27	102					0	0	0.009535	0	0
OR2M3	127062	broad.mit.edu	37	1	248366414	248366414	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:248366414G>T	uc010pzg.1	+	1	45	c.45G>T	c.(43-45)CTG>CTT	p.L15L		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	15	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCATCCTCCTGGGAATCTTCA	0.463			NA											52	187					4.09171e-25	7.44041e-25	0.00361	1	0
OR2T12	127064	broad.mit.edu	37	1	248458257	248458257	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:248458257G>T	uc010pzj.1	-	1	624	c.624C>A	c.(622-624)CCC>CCA	p.P208P		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			TGAGGGAAAAGGGGACCAGGA	0.547			NA											40	52					4.67007e-22	8.16271e-22	0.00874	1	0
OR14C36	127066	broad.mit.edu	37	1	248512430	248512430	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:248512430T>A	uc010pzl.1	+	1	354	c.354T>A	c.(352-354)CAT>CAA	p.H118Q		NM_001001918	NP_001001918	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C,	118	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TTATGGCTCATGACCGCTATG	0.502			NA											13	16					0	0	0.001855	0	0
OR14C36	127066	broad.mit.edu	37	1	248512455	248512455	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:248512455C>A	uc010pzl.1	+	1	379	c.379C>A	c.(379-381)CCA>ACA	p.P127T		NM_001001918	NP_001001918	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C,	127	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TGTCTGCCAGCCACTTCACTA	0.507			NA											18	19					2.35188e-11	3.27673e-11	0.006122	1	0
OR2T4	127074	broad.mit.edu	37	1	248525105	248525105	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:248525105G>A	uc001ieh.1	+	1	223	c.223G>A	c.(223-225)GCT>ACT	p.A75T		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	75	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTCTGGAAATGCTGTCCTGAT	0.463			NA											21	252					0	0	0.004656	0	0
OR2T6	254879	broad.mit.edu	37	1	248551323	248551323	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:248551323G>T	uc001iei.1	+	1	414	c.414G>T	c.(412-414)TGG>TGT	p.W138C		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	138	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCATCAGCTGGCGGGTCTGCT	0.582			NA											26	32					4.22769e-11	5.82824e-11	0.00632	1	0
OR2T1	26696	broad.mit.edu	37	1	248569867	248569867	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:248569867G>T	uc010pzm.1	+	1	572	c.572G>T	c.(571-573)TGT>TTT	p.C191F		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	191	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CGCCGGGTCTGTTGGATGATT	0.547			NA											51	41					6.9144e-35	1.30164e-34	0.00361	1	0
OR2T2	401992	broad.mit.edu	37	1	248616317	248616317	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:248616317C>A	uc001iek.1	+	1	219	c.219C>A	c.(217-219)ATC>ATA	p.I73I		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGGATACCATCTACATCTGTA	0.512			NA											11	113					6.44725e-10	8.56861e-10	0.002299	1	0
OR2T27	403239	broad.mit.edu	37	1	248813466	248813466	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:248813466G>T	uc010pzo.1	-	1	720	c.720C>A	c.(718-720)ACC>ACA	p.T240T		NM_001001824	NP_001001824	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T,	240	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTGAGGAGCAGGTGGCCACAG	0.527			NA											10	13					1.08611e-07	1.35482e-07	0.000978	1	0
SFMBT2	57713	broad.mit.edu	37	10	7290516	7290516	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:7290516C>T	uc009xio.1	-	8	1057	c.966G>A	c.(964-966)GTG>GTA	p.V322V	SFMBT2_uc001ijn.1_Silent_p.V322V|SFMBT2_uc010qay.1_Silent_p.V322V	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	322	MBT 3.				regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						CCACCTTAGTCACCGACGCAG	0.493			NA											8	14					0	0	0.006214	0	0
CACNB2	783	broad.mit.edu	37	10	18825057	18825057	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:18825057G>A	uc001ipr.2	+	12	1294	c.1234G>A	c.(1234-1236)GGG>AGG	p.G412R	CACNB2_uc009xjz.1_Missense_Mutation_p.G162R|CACNB2_uc001ips.2_Missense_Mutation_p.G388R|CACNB2_uc001ipt.2_Missense_Mutation_p.G374R|CACNB2_uc001ipu.2_Missense_Mutation_p.G384R|CACNB2_uc001ipv.2_Missense_Mutation_p.G360R|CACNB2_uc009xka.1_Missense_Mutation_p.G346R|CACNB2_uc001ipw.2_Missense_Mutation_p.G319R|CACNB2_uc001ipx.2_Missense_Mutation_p.G357R|CACNB2_uc001ipz.2_Missense_Mutation_p.G334R|CACNB2_uc001ipy.2_Missense_Mutation_p.G358R|CACNB2_uc010qco.1_Missense_Mutation_p.G326R|CACNB2_uc001iqa.2_Missense_Mutation_p.G364R|NSUN6_uc001iqb.2_Intron	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	412					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AAAATCTCGAGGGAAATCTCA	0.368			NA											8	15					0	0	0.004482	0	0
GPR158	57512	broad.mit.edu	37	10	25887426	25887426	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:25887426C>A	uc001isj.2	+	11	2931	c.2871C>A	c.(2869-2871)GCC>GCA	p.A957A	GPR158_uc001isk.2_Silent_p.A332A	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	957	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						AAGATCCTGCCCCCCAAAACT	0.443			NA											28	32					2.61193e-14	3.96464e-14	0.009535	1	0
MYO3A	53904	broad.mit.edu	37	10	26446271	26446271	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:26446271G>T	uc001isn.2	+	26	3186	c.2826G>T	c.(2824-2826)GTG>GTT	p.V942V	MYO3A_uc009xko.1_Silent_p.V942V|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	942	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						CTAAAATGGTGGTGGGCCAAC	0.393			NA											18	12					8.10497e-08	1.01718e-07	0.010504	1	0
KIAA1462	57608	broad.mit.edu	37	10	30315157	30315157	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:30315157C>A	uc001iux.2	-	2	3979	c.3920G>T	c.(3919-3921)AGT>ATT	p.S1307I	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.S1169I|KIAA1462_uc009xle.1_Missense_Mutation_p.S1307I	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1307										ovary(4)	4						ACGGTCCCCACTGCCAGGAGA	0.622			NA											21	44					2.89027e-11	3.99594e-11	0.002299	1	0
ZNF33A	7581	broad.mit.edu	37	10	38305835	38305835	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:38305835G>T	uc001izh.2	+	3	224	c.46G>T	c.(46-48)GAT>TAT	p.D16Y	ZNF33A_uc001izg.2_Missense_Mutation_p.D16Y|ZNF33A_uc010qev.1_Missense_Mutation_p.D23Y|ZNF33A_uc001izi.1_Missense_Mutation_p.D16Y|ZNF33A_uc001izj.2_RNA	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	16	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						ATCATTTAAAGATGTGACTGT	0.453			NA											30	21					8.88839e-20	1.50612e-19	0.002096	1	0
CSGALNACT2	55454	broad.mit.edu	37	10	43651075	43651075	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:43651075G>T	uc001jan.2	+	2	813	c.478G>T	c.(478-480)GAA>TAA	p.E160*	CSGALNACT2_uc001jam.1_Nonsense_Mutation_p.E160*	NM_018590	NP_061060	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate	160	Lumenal (Potential).				chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			ovary(1)	1						ATTTCAATTGGAAATGGGTCT	0.408			NA											21	58					9.95505e-16	1.55696e-15	0.002299	1	0
OR13A1	79290	broad.mit.edu	37	10	45799695	45799695	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:45799695C>A	uc001jcc.1	-	4	485	c.176G>T	c.(175-177)GGT>GTT	p.G59V	OR13A1_uc001jcd.1_Missense_Mutation_p.G55V	NM_001004297	NP_001004297	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A,	59	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GAGGACATTACCTGTGAGGGC	0.502			NA											11	30					2.27111e-07	2.78718e-07	0.001368	1	0
NCOA4	8031	broad.mit.edu	37	10	51584853	51584853	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:51584853G>C	uc001jis.3	+	8	1155	c.952G>C	c.(952-954)GAG>CAG	p.E318Q	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron|NCOA4_uc009xon.2_Missense_Mutation_p.E334Q|NCOA4_uc010qhd.1_Missense_Mutation_p.E334Q|NCOA4_uc010qhe.1_Missense_Mutation_p.E218Q|NCOA4_uc010qhf.1_Missense_Mutation_p.E152Q|NCOA4_uc001jit.2_Missense_Mutation_p.E318Q|NCOA4_uc009xoo.2_Missense_Mutation_p.E318Q	NM_001145263	NP_001138735	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4 isoform 3	318					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			central_nervous_system(1)|kidney(1)	2						GCGGAAGCCTGAGAATGGCAG	0.453			NA	T	RET	papillary thyroid 								27	35					0	0	0.00632	0	0
PCDH15	65217	broad.mit.edu	37	10	55587240	55587240	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:55587240G>T	uc001jju.1	-	32	4675	c.4280C>A	c.(4279-4281)CCG>CAG	p.P1427Q	PCDH15_uc010qhq.1_Missense_Mutation_p.P1432Q|PCDH15_uc010qhr.1_Missense_Mutation_p.P1427Q|PCDH15_uc010qhs.1_Missense_Mutation_p.P1439Q|PCDH15_uc010qht.1_Missense_Mutation_p.P1434Q|PCDH15_uc010qhu.1_Missense_Mutation_p.P1427Q|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.P1424Q|PCDH15_uc010qhw.1_Missense_Mutation_p.P1387Q|PCDH15_uc010qhx.1_Missense_Mutation_p.P1356Q|PCDH15_uc010qhy.1_Missense_Mutation_p.P1432Q|PCDH15_uc010qhz.1_Missense_Mutation_p.P1427Q|PCDH15_uc010qia.1_Missense_Mutation_p.P1405Q|PCDH15_uc010qib.1_Missense_Mutation_p.P1402Q	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1427	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TGCAGGAGCCGGCACTGCTGG	0.438			NA								HNSCC(58;0.16)			16	40					4.14922e-12	5.89475e-12	0.004007	1	0
PCDH15	65217	broad.mit.edu	37	10	56138679	56138679	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:56138679G>T	uc001jju.1	-	4	576	c.181C>A	c.(181-183)CTG>ATG	p.L61M	PCDH15_uc010qhq.1_Missense_Mutation_p.L66M|PCDH15_uc010qhr.1_Missense_Mutation_p.L61M|PCDH15_uc010qhs.1_Missense_Mutation_p.L66M|PCDH15_uc010qht.1_Missense_Mutation_p.L61M|PCDH15_uc010qhu.1_Missense_Mutation_p.L61M|PCDH15_uc001jjv.1_Missense_Mutation_p.L39M|PCDH15_uc010qhv.1_Missense_Mutation_p.L61M|PCDH15_uc010qhw.1_Missense_Mutation_p.L61M|PCDH15_uc010qhx.1_Missense_Mutation_p.L61M|PCDH15_uc010qhy.1_Missense_Mutation_p.L66M|PCDH15_uc010qhz.1_Missense_Mutation_p.L61M|PCDH15_uc010qia.1_Missense_Mutation_p.L39M|PCDH15_uc010qib.1_Missense_Mutation_p.L39M|PCDH15_uc001jjw.2_Missense_Mutation_p.L61M	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	61	Cadherin 1.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CCTTTGATCAGCATGTTGTCC	0.403			NA								HNSCC(58;0.16)			35	94					1.30998e-17	2.13205e-17	0.005524	1	0
ANK3	288	broad.mit.edu	37	10	62038534	62038534	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:62038534G>A	uc001jky.2	-	4	604	c.412C>T	c.(412-414)CAG>TAG	p.Q138*	ANK3_uc010qih.1_Nonsense_Mutation_p.Q121*|ANK3_uc001jkz.3_Nonsense_Mutation_p.Q132*|ANK3_uc001jlb.1_5'UTR	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	138					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						AGGCTTACCTGAGATTGTGCA	0.423			NA											30	92					0	0	0.002096	0	0
ZNF365	22891	broad.mit.edu	37	10	64429973	64429973	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:64429973T>A	uc001jmd.1	+	7	897	c.563T>A	c.(562-564)TTG>TAG	p.L188*	ZNF365_uc001jmc.2_Nonsense_Mutation_p.L434*|ZNF365_uc001jme.1_RNA|ZNF365_uc001jmf.1_RNA|ZNF365_uc009xpg.1_RNA	NM_199452	NP_955524	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform D	188										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					ATAGGCAAATTGACAATCATC	0.448			NA											61	138					0	0	0.00361	0	0
JMJD1C	221037	broad.mit.edu	37	10	64967354	64967354	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:64967354C>A	uc001jmn.2	-	10	4375	c.4075G>T	c.(4075-4077)GTG>TTG	p.V1359L	JMJD1C_uc001jml.2_Missense_Mutation_p.V1140L|JMJD1C_uc001jmm.2_Missense_Mutation_p.V1071L|JMJD1C_uc010qiq.1_Missense_Mutation_p.V1177L|JMJD1C_uc009xpi.2_Missense_Mutation_p.V1177L|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_Missense_Mutation_p.V396L	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1359					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					TCTGAATTCACATTTGGCAAA	0.418			NA											24	82					1.10513e-12	1.5952e-12	0.002299	1	0
LRRTM3	347731	broad.mit.edu	37	10	68686853	68686853	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:68686853C>G	uc001jmz.1	+	2	729	c.179C>G	c.(178-180)TCT>TGT	p.S60C	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Missense_Mutation_p.S60C	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	60	Extracellular (Potential).|LRRNT.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						TCAAGTATATCTGCTGGTTGC	0.428			NA											18	43					0	0	0.007413	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72511358	72511358	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:72511358G>A	uc001jrh.2	+	17	2552	c.2552G>A	c.(2551-2553)TGG>TAG	p.W851*	ADAMTS14_uc001jrg.2_Nonsense_Mutation_p.W854*	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	851	TSP type-1 2.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						ACCTATGAGTGGGCGCTCAAG	0.622			NA											13	27					0	0	0.001855	0	0
MYST4	23522	broad.mit.edu	37	10	76736061	76736061	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:76736061G>A	uc001jwn.1	+	8	2459	c.1966G>A	c.(1966-1968)GGA>AGA	p.G656R	MYST4_uc001jwm.1_Intron|MYST4_uc001jwo.1_Intron|MYST4_uc001jwp.1_Intron	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	656	Negatively regulates HAT activity.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					CTTGACAGACGGAAGGATTAA	0.478			NA	T	CREBBP	AML								3	42					0	0	0.009096	0	0
DYDC2	84332	broad.mit.edu	37	10	82122242	82122242	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:82122242G>T	uc001kca.1	+	3	423	c.43G>T	c.(43-45)GCC>TCC	p.A15S	DYDC2_uc001kbz.1_RNA|DYDC2_uc001kcb.1_Missense_Mutation_p.A15S	NM_032372	NP_115748	Q96IM9	DYDC2_HUMAN	DPY30 domain containing 2	15							protein binding				0			Colorectal(32;0.229)			AAATTGCCTGGCCCAGGCACT	0.453			NA											13	28					2.27111e-07	2.78718e-07	0.001368	1	0
GRID1	2894	broad.mit.edu	37	10	87487652	87487652	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:87487652T>G	uc001kdl.1	-	10	1594	c.1493A>C	c.(1492-1494)AAC>ACC	p.N498T	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.N69T	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	498	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	CCAGGAGGTGTTATGGAGCTG	0.552			NA								Multiple Myeloma(13;0.14)			11	63					0	0	0.008291	0	0
MMRN2	79812	broad.mit.edu	37	10	88702981	88702981	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:88702981C>A	uc001kea.2	-	6	1687	c.1560G>T	c.(1558-1560)GTG>GTT	p.V520V	MMRN2_uc010qmn.1_Silent_p.V163V|MMRN2_uc009xtb.2_Silent_p.V477V	NM_024756	NP_079032	Q9H8L6	MMRN2_HUMAN	multimerin 2 precursor	520						extracellular space				large_intestine(1)	1						CGTCCAGGCTCACCTGGGTCT	0.667			NA											11	23					1.58986e-06	1.8947e-06	0.008291	1	0
IFIT1B	439996	broad.mit.edu	37	10	91143527	91143527	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:91143527G>A	uc001kgh.2	+	2	537	c.457G>A	c.(457-459)GGA>AGA	p.G153R	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron	NM_001010987	NP_001010987	Q5T764	IFT1B_HUMAN	interferon-induced protein with	153	TPR 3.						binding				0						GGCGAAGTGTGGTGGAAAGAA	0.493			NA											20	39					0	0	0.001882	0	0
IFIT1B	439996	broad.mit.edu	37	10	91143649	91143649	+	Silent	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:91143649A>G	uc001kgh.2	+	2	659	c.579A>G	c.(577-579)ACA>ACG	p.T193T	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron	NM_001010987	NP_001010987	Q5T764	IFT1B_HUMAN	interferon-induced protein with	193	TPR 4.						binding				0						AATTTAACACAGCATCAGGGA	0.458			NA											64	157					0	0	0.00361	0	0
TM9SF3	56889	broad.mit.edu	37	10	98307744	98307744	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:98307744C>A	uc001kmm.3	-	8	1179	c.962G>T	c.(961-963)AGG>ATG	p.R321M	TM9SF3_uc010qot.1_Missense_Mutation_p.R321M|TM9SF3_uc001kmn.1_Missense_Mutation_p.R90M	NM_020123	NP_064508	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3 precursor	321						integral to membrane	binding				0		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		CATTGATCCCCTCCTAAAAAG	0.318			NA											17	37					0.006122	0.00644375	0.006122	1	0
PIK3AP1	118788	broad.mit.edu	37	10	98411027	98411027	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:98411027C>T	uc001kmq.2	-	6	1094	c.966G>A	c.(964-966)CTG>CTA	p.L322L	PIK3AP1_uc001kmp.2_Silent_p.L144L	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	322						cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		CTTCTTCTTCCAGCTGGTTGA	0.468			NA											13	23					0	0	0.004007	0	0
ARHGAP19	84986	broad.mit.edu	37	10	99016090	99016090	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:99016090G>A	uc001knb.2	-	6	941	c.912C>T	c.(910-912)TCC>TCT	p.S304S	ARHGAP19_uc001kmy.2_RNA|ARHGAP19_uc001kna.2_Silent_p.S295S|ARHGAP19_uc009xvi.2_RNA|ARHGAP19_uc009xvj.2_Intron|ARHGAP19_uc009xvk.2_Silent_p.S98S	NM_032900	NP_116289	Q14CB8	RHG19_HUMAN	Rho GTPase activating protein 19	304	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	GTPase activator activity				0		Colorectal(252;0.0854)		Epithelial(162;7.65e-09)|all cancers(201;4.49e-07)		AAAGTTTCTGGGAGTGTTTAA	0.393			NA											5	142					0	0	0.001984	0	0
BTRC	8945	broad.mit.edu	37	10	103221745	103221745	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:103221745C>A	uc001kta.2	+	3	277	c.164C>A	c.(163-165)TCA>TAA	p.S55*	BTRC_uc001ksz.1_Intron|BTRC_uc001ktb.2_Nonsense_Mutation_p.S19*|BTRC_uc001ktc.2_Intron	NM_033637	NP_378663	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing protein	55					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		CAGAATTCCTCAGAGAGAGAA	0.328			NA											12	47					0.00185496	0.0019917	0.001855	1	0
C10orf76	79591	broad.mit.edu	37	10	103773745	103773745	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:103773745C>G	uc009xwy.1	-	9	808	c.706G>C	c.(706-708)GAT>CAT	p.D236H		NM_024541	NP_078817	Q5T2E6	CJ076_HUMAN	hypothetical protein LOC79591	236						integral to membrane					0		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)		GCCTCATCATCCACGATAGAC	0.378			NA											31	47					0	0	0.002445	0	0
PPRC1	23082	broad.mit.edu	37	10	103898426	103898426	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:103898426G>T	uc001kum.2	+	3	432	c.393G>T	c.(391-393)CTG>CTT	p.L131L	PPRC1_uc001kun.2_Intron|PPRC1_uc010qqj.1_Silent_p.L131L|PPRC1_uc009xxa.2_5'Flank	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		TCACGGCTCTGACGGAGATCT	0.512			NA											18	31					1.99824e-07	2.46911e-07	0.00499	1	0
ITPRIP	85450	broad.mit.edu	37	10	106074637	106074637	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:106074637G>T	uc001kye.2	-	2	1246	c.1173C>A	c.(1171-1173)TTC>TTA	p.F391L	ITPRIP_uc001kyf.2_Missense_Mutation_p.F391L|ITPRIP_uc001kyg.2_Missense_Mutation_p.F391L	NM_033397	NP_203755	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-triphosphate receptor interacting	391						plasma membrane					0						TCGTCCTGAGGAAGTGTCGCT	0.617			NA											15	23					2.48551e-13	3.65724e-13	0.00499	1	0
SORCS3	22986	broad.mit.edu	37	10	106974319	106974319	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:106974319G>T	uc001kyi.1	+	18	2722	c.2495G>T	c.(2494-2496)CGG>CTG	p.R832L	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	832	PKD.|Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ACCGATGGGCGGCTGGTGGCA	0.582	NSCLC(116;1497 1690 7108 13108 14106)		NA											9	19					1.12685e-05	1.30516e-05	0.004482	1	0
SORCS1	114815	broad.mit.edu	37	10	108339226	108339226	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:108339226A>G	uc001kym.2	-	25	3280	c.3272T>C	c.(3271-3273)CTG>CCG	p.L1091P	SORCS1_uc001kyl.2_Missense_Mutation_p.L1091P|SORCS1_uc009xxs.2_Missense_Mutation_p.L1091P|SORCS1_uc001kyn.1_Missense_Mutation_p.L1091P|SORCS1_uc001kyo.2_Missense_Mutation_p.L1091P	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	1091	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GAGGTCCACCAGGGGGGCTTG	0.517			NA											6	22					0	0	0.00308	0	0
SORCS1	114815	broad.mit.edu	37	10	108339228	108339228	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:108339228G>T	uc001kym.2	-	25	3278	c.3270C>A	c.(3268-3270)CCC>CCA	p.P1090P	SORCS1_uc001kyl.2_Silent_p.P1090P|SORCS1_uc009xxs.2_Silent_p.P1090P|SORCS1_uc001kyn.1_Silent_p.P1090P|SORCS1_uc001kyo.2_Silent_p.P1090P	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	1090	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GGTCCACCAGGGGGGCTTGTG	0.512			NA											6	21					0.00307968	0.003275	0.00308	1	0
SORCS1	114815	broad.mit.edu	37	10	108427524	108427524	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:108427524G>T	uc001kym.2	-	17	2234	c.2226C>A	c.(2224-2226)TGC>TGA	p.C742*	SORCS1_uc001kyl.2_Nonsense_Mutation_p.C742*|SORCS1_uc009xxs.2_Nonsense_Mutation_p.C742*|SORCS1_uc001kyn.1_Nonsense_Mutation_p.C742*|SORCS1_uc001kyo.2_Nonsense_Mutation_p.C742*	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	742	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ATGCCGGCAGGCACTGGCCAT	0.458			NA											8	18					0.00621372	0.00653551	0.006214	1	0
SORCS1	114815	broad.mit.edu	37	10	108466379	108466379	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:108466379C>A	uc001kym.2	-	8	1165	c.1157G>T	c.(1156-1158)GGG>GTG	p.G386V	SORCS1_uc001kyl.2_Missense_Mutation_p.G386V|SORCS1_uc009xxs.2_Missense_Mutation_p.G386V|SORCS1_uc001kyn.1_Missense_Mutation_p.G386V|SORCS1_uc001kyo.2_Missense_Mutation_p.G386V	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	386	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ATGTGGCCGCCCTCCTGATGT	0.468			NA											7	46					1.6384e-10	2.21422e-10	0.001984	1	0
DUSP5	1847	broad.mit.edu	37	10	112269834	112269834	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:112269834C>T	uc001kzd.2	+	4	1060	c.805C>T	c.(805-807)CGT>TGT	p.R269C		NM_004419	NP_004410	Q16690	DUS5_HUMAN	dual specificity phosphatase 5	269	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1		Breast(234;0.0848)		Epithelial(162;0.000276)|all cancers(201;0.00465)|BRCA - Breast invasive adenocarcinoma(275;0.12)		TGGGATCTCCCGTTCACCCAC	0.537			NA											9	38					0	0	0.004482	0	0
NHLRC2	374354	broad.mit.edu	37	10	115668189	115668189	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:115668189A>T	uc001lax.1	+	11	2287	c.2075A>T	c.(2074-2076)GAC>GTC	p.D692V	NHLRC2_uc001lay.1_RNA	NM_198514	NP_940916	Q8NBF2	NHLC2_HUMAN	NHL repeat containing 2	692					cell redox homeostasis					ovary(1)	1				Epithelial(162;0.017)|all cancers(201;0.0187)		TGTAGTGCAGACAGCAGTGCT	0.393			NA											91	60					0	0	0.00361	0	0
TRUB1	142940	broad.mit.edu	37	10	116719515	116719515	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:116719515G>T	uc001lcd.2	+	4	533	c.472G>T	c.(472-474)GCT>TCT	p.A158S	TRUB1_uc010qsl.1_Missense_Mutation_p.A60S	NM_139169	NP_631908	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase homolog 1	158					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding				0		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		ACTGGGGAAAGCTACTGATAC	0.413			NA											57	23					7.10663e-31	1.324e-30	0.00361	1	0
PNLIPRP3	119548	broad.mit.edu	37	10	118220478	118220478	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:118220478G>T	uc001lcl.3	+	6	667	c.566G>T	c.(565-567)GGG>GTG	p.G189V		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	189					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		CTTTCTCTAGGGTTGGACCCA	0.423			NA											14	29					1.5842e-08	2.03602e-08	0.001855	1	0
PNLIPRP3	119548	broad.mit.edu	37	10	118231387	118231387	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:118231387G>T	uc001lcl.3	+	10	1269	c.1168G>T	c.(1168-1170)GTC>TTC	p.V390F		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	390	PLAT.				lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		GTTTGCCATTGTCAGGTAGGC	0.483			NA											8	25					1.15088e-07	1.43066e-07	0.004007	1	0
PNLIP	5406	broad.mit.edu	37	10	118306841	118306841	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:118306841A>T	uc001lcm.2	+	3	125	c.82A>T	c.(82-84)AGT>TGT	p.S28C		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	28					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	CGGCTGCTTCAGTGATGACTC	0.428			NA											22	53					0	0	0.00278	0	0
PPAPDC1A	196051	broad.mit.edu	37	10	122334784	122334784	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:122334784G>C	uc001lev.1	+	6	939	c.587G>C	c.(586-588)CGC>CCC	p.R196P	PPAPDC1A_uc010qtd.1_Missense_Mutation_p.R196P|PPAPDC1A_uc009xzl.1_Missense_Mutation_p.R133P|PPAPDC1A_uc001lew.1_3'UTR|PPAPDC1A_uc001lex.1_Intron|PPAPDC1A_uc001ley.1_Missense_Mutation_p.R75P	NM_001030059	NP_001025230	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain	196	Phosphatase sequence motif III.|Helical; (Potential).				phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)	1		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		GCCCTGTCCCGCATGTGCGAC	0.607			NA											18	36					0	0	0.007413	0	0
ATE1	11101	broad.mit.edu	37	10	123661976	123661976	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:123661976G>A	uc001lfp.2	-	6	825	c.743C>T	c.(742-744)TCC>TTC	p.S248F	ATE1_uc001lfq.2_Missense_Mutation_p.S248F|ATE1_uc010qtr.1_Missense_Mutation_p.S133F|ATE1_uc010qts.1_Missense_Mutation_p.S152F|ATE1_uc010qtt.1_Missense_Mutation_p.S241F|ATE1_uc001lfr.2_Intron|ATE1_uc009xzu.2_Intron	NM_007041	NP_008972	O95260	ATE1_HUMAN	arginyltransferase 1 isoform 2	248					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity				0		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				TGGCTGGTTGGATTTAGCCTT	0.413			NA											33	164					0	0	0.004878	0	0
TACC2	10579	broad.mit.edu	37	10	123987514	123987514	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:123987514G>T	uc001lfv.2	+	14	8247	c.7887G>T	c.(7885-7887)GCG>GCT	p.A2629A	TACC2_uc001lfw.2_Silent_p.A775A|TACC2_uc009xzx.2_Silent_p.A2584A|TACC2_uc010qtv.1_Silent_p.A2633A|TACC2_uc001lfx.2_Silent_p.A333A|TACC2_uc001lfy.2_Silent_p.A329A|TACC2_uc001lfz.2_Silent_p.A707A|TACC2_uc001lga.2_Silent_p.A707A|TACC2_uc009xzy.2_Silent_p.A719A|TACC2_uc001lgb.2_Silent_p.A664A	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2629						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CTTCAGAAGCGATTGAAATTG	0.572			NA											99	56					9.07443e-57	1.74704e-56	0.00361	1	0
HMX3	340784	broad.mit.edu	37	10	124897076	124897076	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:124897076G>T	uc010quc.1	+	2	903	c.903G>T	c.(901-903)CAG>CAT	p.Q301H		NM_001105574	NP_001099044	A6NHT5	HMX3_HUMAN	H6 family homeobox 3	301					cell differentiation	nucleus	sequence-specific DNA binding transcription factor activity				0		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.122)|COAD - Colon adenocarcinoma(40;0.141)		CCGCGGCGCAGCGCATCGTGC	0.527			NA											8	15					1.06961e-07	1.33771e-07	0.00308	1	0
OAT	4942	broad.mit.edu	37	10	126100674	126100674	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:126100674C>A	uc001lhp.2	-	2	174	c.67G>T	c.(67-69)GCT>TCT	p.A23S	OAT_uc001lhq.2_RNA|OAT_uc001lhr.2_Intron	NM_000274	NP_000265	P04181	OAT_HUMAN	ornithine aminotransferase precursor	23					cellular amino acid biosynthetic process|visual perception	mitochondrial matrix	ornithine-oxo-acid transaminase activity|protein binding|pyridoxal phosphate binding				0		all_lung(145;0.0271)|Lung NSC(174;0.0436)|Colorectal(57;0.102)|all_neural(114;0.116)			L-Ornithine(DB00129)|Pyridoxal Phosphate(DB00114)	GTAGCAGAAGCCACTGAAGAA	0.418			NA											127	62					2.47456e-63	4.78327e-63	0.00361	1	0
FANK1	92565	broad.mit.edu	37	10	127693610	127693610	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:127693610G>A	uc001ljh.3	+	7	801	c.697G>A	c.(697-699)GGC>AGC	p.G233S	FANK1_uc009yan.2_Missense_Mutation_p.G259S|FANK1_uc001lji.2_Missense_Mutation_p.G227S	NM_145235	NP_660278	Q8TC84	FANK1_HUMAN	fibronectin type III and ankyrin repeat domains	233	ANK 4.					cytoplasm|nucleus				ovary(1)	1		all_lung(145;0.00752)|Lung NSC(174;0.0115)|Colorectal(57;0.0847)|all_neural(114;0.0936)				GATAAAGGATGGCTGTGAGGT	0.542			NA											37	72					0	0	0.005524	0	0
MRGPRE	116534	broad.mit.edu	37	11	3249866	3249866	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:3249866C>T	uc001lxq.3	-	2	471	c.161G>A	c.(160-162)AGA>AAA	p.R54K		NM_001039165	NP_001034254	Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	54	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(1)|ovary(1)	2		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAAGGGGTTTCTGTAGACATT	0.632			NA											26	59					0	0	0.005443	0	0
OR51F1	256892	broad.mit.edu	37	11	4790226	4790226	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:4790226G>T	uc010qyl.1	-	1	922	c.922C>A	c.(922-924)CTG>ATG	p.L308M		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	308						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		GTAAGCAGCAGACTGAGCATA	0.418			NA											28	27					1.2476e-16	1.99009e-16	0.00632	1	0
OR52J3	119679	broad.mit.edu	37	11	5068433	5068433	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:5068433C>A	uc010qyv.1	+	1	678	c.678C>A	c.(676-678)GTC>GTA	p.V226V		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCCGTGCTGTCTTCCGCCTCC	0.443			NA											47	78					1.51926e-22	2.67167e-22	0.00361	1	0
OR51B2	79345	broad.mit.edu	37	11	5344970	5344970	+	Silent	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:5344970A>G	uc001mao.1	-	1	613	c.558T>C	c.(556-558)GCT>GCC	p.A186A	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	186	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTCAGCACAAGCCAGTCTCA	0.373			NA											8	55					0	0	0.004482	0	0
OR51I1	390063	broad.mit.edu	37	11	5461847	5461847	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:5461847C>A	uc010qze.1	-	1	898	c.898G>T	c.(898-900)GAG>TAG	p.E300*	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005288	NP_001005288	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTGCGGATCTCCTTGGTTTTC	0.473			NA											25	52					1.04121e-07	1.30446e-07	0.005443	1	0
UBQLNL	143630	broad.mit.edu	37	11	5537474	5537474	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:5537474C>T	uc001maz.3	-	1	483	c.198G>A	c.(196-198)CAG>CAA	p.Q66Q	HBG2_uc001mak.1_Intron	NM_145053	NP_659490	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	66	Ubiquitin-like.									large_intestine(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		GTTGGTCCATCTGGCATTGGA	0.493			NA											14	28					0	0	0.00245	0	0
OR56B1	387748	broad.mit.edu	37	11	5758365	5758365	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:5758365T>A	uc001mbt.1	+	1	619	c.619T>A	c.(619-621)TGC>AGC	p.C207S	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005180	NP_001005180	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		AAACAGCATTTGCCAGTTGGT	0.443			NA											6	39					0	0	0.001168	0	0
OR56A1	120796	broad.mit.edu	37	11	6047984	6047984	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:6047984C>A	uc010qzw.1	-	1	951	c.951G>T	c.(949-951)GGG>GGT	p.G317G		NM_001001917	NP_001001917	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A,	317	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATATTCACCTCCCTCTCTGCA	0.413			NA											14	25					1.49906e-05	1.72931e-05	0.00245	1	0
CCKBR	887	broad.mit.edu	37	11	6292659	6292659	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:6292659C>A	uc001mcp.2	+	5	1423	c.1230C>A	c.(1228-1230)CCC>CCA	p.P410P	CCKBR_uc001mcq.2_Silent_p.P338P|CCKBR_uc001mcr.2_Silent_p.P393P|CCKBR_uc001mcs.2_Silent_p.P479P	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	410	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	GCTGCTGCCCCCGGCCTCCAC	0.642			NA											21	48					4.35082e-09	5.69317e-09	0.010504	1	0
DNHD1	144132	broad.mit.edu	37	11	6588935	6588935	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:6588935C>T	uc001mdw.3	+	36	12760	c.12196C>T	c.(12196-12198)CGG>TGG	p.R4066W	DNHD1_uc001mea.3_Missense_Mutation_p.R335W|DNHD1_uc001meb.2_Missense_Mutation_p.R334W|DNHD1_uc001mec.2_Missense_Mutation_p.R334W|DNHD1_uc010rao.1_Missense_Mutation_p.R324W|DNHD1_uc009yfg.2_5'Flank	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4066					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CCTCCTGGGTCGGCCCCTGGA	0.602			NA											8	59					0	0	0.000978	0	0
DCHS1	8642	broad.mit.edu	37	11	6662136	6662136	+	Missense_Mutation	SNP	C	C	A	rs149950385		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:6662136C>A	uc001mem.1	-	2	1119	c.709G>T	c.(709-711)GCC>TCC	p.A237S		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	237	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGGCCTGGGCCCTCCGGGGG	0.597			NA											26	68					4.87955e-14	7.3295e-14	0.005443	1	0
ZNF215	7762	broad.mit.edu	37	11	6977037	6977037	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:6977037C>A	uc001mey.2	+	7	1417	c.829C>A	c.(829-831)CAG>AAG	p.Q277K	ZNF215_uc010raw.1_3'UTR|ZNF215_uc010rax.1_Missense_Mutation_p.Q39K|ZNF215_uc001mez.1_Intron	NM_013250	NP_037382	Q9UL58	ZN215_HUMAN	zinc finger protein 215	277					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		ATATAGGAACCAGAAAAAATG	0.393			NA											36	86					1.07121e-22	1.88836e-22	0.006999	1	0
NLRP10	338322	broad.mit.edu	37	11	7981222	7981222	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:7981222G>C	uc001mfv.1	-	2	1954	c.1937C>G	c.(1936-1938)ACA>AGA	p.T646R		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	646							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TGTTTCCTCTGTCCCTCTGCC	0.259			NA											8	35					0	0	0.004482	0	0
STK33	65975	broad.mit.edu	37	11	8496413	8496413	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:8496413G>A	uc001mgi.1	-	1	959	c.40C>T	c.(40-42)CCC>TCC	p.P14S	STK33_uc001mgj.1_Missense_Mutation_p.P14S|STK33_uc001mgk.1_Missense_Mutation_p.P14S|STK33_uc010rbn.1_Intron|STK33_uc001mgl.3_Intron|STK33_uc009yfp.2_Intron	NM_030906	NP_112168	Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	14						Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|pancreas(1)|central_nervous_system(1)|skin(1)	7				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		GAACAGTCGGGGCATTTTGTG	0.393			NA											33	85					0	0	0.004878	0	0
DENND5A	23258	broad.mit.edu	37	11	9199820	9199820	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:9199820T>C	uc001mhl.2	-	8	2020	c.1765A>G	c.(1765-1767)ATA>GTA	p.I589V	DENND5A_uc010rbw.1_Missense_Mutation_p.I589V|DENND5A_uc010rbx.1_RNA	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	589										liver(1)	1						TGACACATTATTTTGTTGTCA	0.468			NA											21	52					0	0	0.008871	0	0
IPO7	10527	broad.mit.edu	37	11	9431591	9431591	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:9431591T>C	uc001mho.2	+	4	579	c.437T>C	c.(436-438)CTA>CCA	p.L146P		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	146					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		GCTTGTTGGCTAGGAATTCTT	0.378			NA											33	28					0	0	0.003755	0	0
CSNK2A1P	283106	broad.mit.edu	37	11	11373917	11373918	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:11373917_11373918CC>AA	uc001mjp.2	-	1	987_988	c.749_750GG>TT	c.(748-750)GGG>GTT	p.G250V	GALNTL4_uc001mjo.2_Intron	NM_177559	NP_808227			casein kinase II alpha 1 subunit isoform a												0						AATCTTCTGTCCCCAGAAACTT	0.416			NA											8	91					0	0	0.004672	0	0
FAR1	84188	broad.mit.edu	37	11	13734550	13734550	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:13734550A>T	uc001mld.2	+	8	1080	c.925A>T	c.(925-927)AGC>TGC	p.S309C	FAR1_uc009ygp.2_Missense_Mutation_p.S309C	NM_032228	NP_115604	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	309					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			ovary(1)|skin(1)	2						TACAACAGGCAGCACTAATCC	0.348			NA											26	94					0	0	0.008361	0	0
KCNJ11	3767	broad.mit.edu	37	11	17409593	17409593	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:17409593G>A	uc001mna.2	-	1	614	c.46C>T	c.(46-48)CGC>TGC	p.R16C	KCNJ11_uc001mnb.3_Intron	NM_000525	NP_000516	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel J11	16						integral to membrane	ATP-activated inward rectifier potassium channel activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		TCTGCCAGGCGTGTCAGCACG	0.657			NA											9	82					0	0	0.004482	0	0
USH1C	10083	broad.mit.edu	37	11	17539001	17539001	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:17539001C>G	uc001mnf.2	-	15	1340	c.1231G>C	c.(1231-1233)GAG>CAG	p.E411Q	USH1C_uc001mne.2_Intron|USH1C_uc009yhb.2_Missense_Mutation_p.E392Q|USH1C_uc001mng.2_Intron|USH1C_uc001mnd.2_Missense_Mutation_p.E375Q	NM_005709	NP_005700	Q9Y6N9	USH1C_HUMAN	harmonin isoform a	411					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1						GGCTCGAGCTCAGGTTCCACT	0.607			NA											4	11					0	0	0.009096	0	0
TPH1	7166	broad.mit.edu	37	11	18044361	18044361	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:18044361C>A	uc001mnp.2	-	9	1170	c.1144G>T	c.(1144-1146)GCA>TCA	p.A382S	TPH1_uc009yhe.2_RNA	NM_004179	NP_004170	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	382					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity				0					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	TTCTCCTTTGCATCTTCAAAA	0.398			NA											17	19					0.00400662	0.00425446	0.004007	1	0
SLC6A5	9152	broad.mit.edu	37	11	20676304	20676304	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:20676304T>G	uc001mqd.2	+	16	2557	c.2284T>G	c.(2284-2286)TTA>GTA	p.L762V	SLC6A5_uc009yic.2_Missense_Mutation_p.L527V	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	762	Cytoplasmic (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	GGGCCCATTCTTAGCTCAACA	0.547			NA											10	125					0	0	0.000978	0	0
NELL1	4745	broad.mit.edu	37	11	20959377	20959377	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:20959377T>G	uc001mqe.2	+	10	1196	c.1043T>G	c.(1042-1044)ATT>AGT	p.I348S	NELL1_uc001mqf.2_Missense_Mutation_p.I348S|NELL1_uc009yid.2_Missense_Mutation_p.I376S|NELL1_uc010rdo.1_Missense_Mutation_p.I291S|NELL1_uc010rdp.1_Missense_Mutation_p.I108S	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	348	VWFC 2.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GGCCAGCGGATTTTAACCAAG	0.408			NA											7	99					0	0	0.00308	0	0
FANCF	2188	broad.mit.edu	37	11	22646301	22646301	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:22646301T>A	uc001mql.1	-	1	1087	c.1056A>T	c.(1054-1056)TTA>TTT	p.L352F		NM_022725	NP_073562	Q9NPI8	FANCF_HUMAN	Fanconi anemia, complementation group F	352					DNA repair	nucleoplasm	protein binding			skin(1)	1						TACGAAGAGCTAATAAGAGGT	0.433			NA	N|F			AML|leukemia		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia		OREG0020844	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	95					0	0	0.002445	0	0
ANO3	63982	broad.mit.edu	37	11	26619958	26619958	+	Silent	SNP	C	C	A	rs148526395		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:26619958C>A	uc001mqt.3	+	15	1639	c.1494C>A	c.(1492-1494)ACC>ACA	p.T498T	ANO3_uc010rdr.1_Silent_p.T482T|ANO3_uc010rds.1_Silent_p.T337T|ANO3_uc010rdt.1_Silent_p.T352T	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	498	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GTATACTGACCTATACTTGGG	0.368			NA											172	81					1.06793e-96	2.08383e-96	0.00361	1	0
DCDC1	341019	broad.mit.edu	37	11	31312394	31312394	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:31312394G>T	uc001msv.2	-	7	962	c.760C>A	c.(760-762)CTG>ATG	p.L254M	DCDC1_uc001msu.1_Intron	NM_181807	NP_861523	P59894	DCDC1_HUMAN	doublecortin domain containing 1	254					intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)					ATTAACAACAGATGGTCTAGA	0.328			NA											14	27					2.23348e-06	2.64207e-06	0.004007	1	0
CCDC73	493860	broad.mit.edu	37	11	32724484	32724484	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:32724484G>A	uc001mtv.2	-	4	258	c.214C>T	c.(214-216)CTT>TTT	p.L72F	CCDC73_uc001mtw.1_Missense_Mutation_p.L72F|CCDC73_uc009yjt.2_Missense_Mutation_p.L72F	NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	72	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					TGATTCTGAAGAGTTTCCTGT	0.318			NA											13	80					0	0	0.001855	0	0
CAPRIN1	4076	broad.mit.edu	37	11	34118027	34118027	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:34118027G>T	uc001mvh.1	+	16	1896	c.1707G>T	c.(1705-1707)GTG>GTT	p.V569V	CAPRIN1_uc001mvg.2_Silent_p.V569V|CAPRIN1_uc001mvi.2_Silent_p.V569V|CAPRIN1_uc001mvj.1_Silent_p.V488V	NM_005898	NP_005889	Q14444	CAPR1_HUMAN	membrane component chromosome 11 surface marker	569					negative regulation of translation|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis	cytoplasmic mRNA processing body|cytosol|dendrite|integral to plasma membrane|stress granule	protein binding|RNA binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.00045)|all_hematologic(20;0.0016)				AAATTATAGTGGTTGGCACTT	0.428			NA											20	33					2.39187e-15	3.71441e-15	0.008871	1	0
PAMR1	25891	broad.mit.edu	37	11	35463195	35463195	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:35463195C>A	uc001mwg.2	-	7	910	c.867G>T	c.(865-867)GGG>GGT	p.G289G	PAMR1_uc001mwf.2_Silent_p.G306G|PAMR1_uc010rew.1_Silent_p.G178G|PAMR1_uc010rex.1_Silent_p.G249G	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	289	Sushi 1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						TTTTCTGGTACCCATTGACTG	0.428			NA											44	52					2.00842e-17	3.25775e-17	0.002522	1	0
LDLRAD3	143458	broad.mit.edu	37	11	36103329	36103329	+	Splice_Site	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:36103329G>T	uc001mwk.1	+	3	356	c.319_splice	c.e3+1	p.T107_splice	LDLRAD3_uc010rey.1_Splice_Site_p.T58_splice|LDLRAD3_uc010rez.1_Splice_Site	NM_174902	NP_777562	Q86YD5	LRAD3_HUMAN	low density lipoprotein receptor class A domain							integral to membrane	receptor activity			central_nervous_system(1)	1	all_lung(20;0.089)|Lung NSC(22;0.175)|all_epithelial(35;0.177)	all_hematologic(20;0.124)				GAGAACTGCAGTAAGTGCTGC	0.527			NA											29	53					1.74807e-11	2.44967e-11	0.002096	1	0
ALKBH3	221120	broad.mit.edu	37	11	43908168	43908168	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:43908168G>T	uc001mxs.2	+	5	674	c.231G>T	c.(229-231)GTG>GTT	p.V77V	ALKBH3_uc009ykp.2_RNA|ALKBH3_uc001mxt.2_RNA|ALKBH3_uc009ykq.2_5'UTR	NM_139178	NP_631917	Q96Q83	ALKB3_HUMAN	AlkB homolog 3	77					DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation	mitochondrion|nucleoplasm	damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0					Vitamin C(DB00126)	GAGAGGGTGTGTATGAAATCA	0.388			NA						Direct_reversal_of_damage					6	36					1.12685e-05	1.30516e-05	0.004482	1	0
PRDM11	56981	broad.mit.edu	37	11	45117395	45117395	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:45117395C>A	uc001myo.2	+	2	288	c.39C>A	c.(37-39)ATC>ATA	p.I13I		NM_020229	NP_064614	Q9NQV5	PRD11_HUMAN	PR domain containing 11	13										upper_aerodigestive_tract(1)	1						ccctgatgatcgtggagtgcc	0.035	NSCLC(118;1511 1736 6472 36603 43224)		NA											19	60					6.44725e-10	8.56861e-10	0.002299	1	0
PRDM11	56981	broad.mit.edu	37	11	45204635	45204635	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:45204635C>T	uc001myo.2	+	5	798	c.549C>T	c.(547-549)ATC>ATT	p.I183I		NM_020229	NP_064614	Q9NQV5	PRD11_HUMAN	PR domain containing 11	183	SET.									upper_aerodigestive_tract(1)	1						AGGGGCAGATCTCCACCCAGG	0.557	NSCLC(118;1511 1736 6472 36603 43224)		NA									OREG0020926	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	22					0	0	0.001855	0	0
HARBI1	283254	broad.mit.edu	37	11	46637683	46637683	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:46637683C>G	uc001ncy.2	-	2	353	c.105G>C	c.(103-105)TTG>TTC	p.L35F	KIAA0652_uc009yld.2_5'Flank|KIAA0652_uc001nda.2_5'Flank|KIAA0652_uc001ndb.2_5'Flank|KIAA0652_uc001ncz.2_5'Flank|KIAA0652_uc001ndc.2_5'Flank|KIAA0652_uc010rgv.1_5'Flank	NM_173811	NP_776172	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	35						cytoplasm|nucleus	metal ion binding|nuclease activity				0						ACATGGACATCAAGTATTCAT	0.478			NA											13	48					0	0	0.001368	0	0
ARHGAP1	392	broad.mit.edu	37	11	46700978	46700978	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:46700978G>A	uc001ndd.2	-	12	1137	c.1068C>T	c.(1066-1068)GTC>GTT	p.V356V		NM_004308	NP_004299	Q07960	RHG01_HUMAN	Rho GTPase activating protein 1	356	Rho-GAP.				Rho protein signal transduction	cytosol|intracellular membrane-bounded organelle	SH3 domain binding|SH3/SH2 adaptor activity			skin(1)	1		Lung NSC(402;1.76e-12)|all_lung(304;1.3e-11)		GBM - Glioblastoma multiforme(35;5.17e-06)|BRCA - Breast invasive adenocarcinoma(625;0.00112)|Lung(87;0.153)		GCGTCTGGAGGACCTGCAGTG	0.597			NA											17	29					0	0	0.008871	0	0
ARHGAP1	392	broad.mit.edu	37	11	46701249	46701249	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:46701249G>T	uc001ndd.2	-	11	1045	c.976C>A	c.(976-978)CCT>ACT	p.P326T		NM_004308	NP_004299	Q07960	RHG01_HUMAN	Rho GTPase activating protein 1	326	Rho-GAP.				Rho protein signal transduction	cytosol|intracellular membrane-bounded organelle	SH3 domain binding|SH3/SH2 adaptor activity			skin(1)	1		Lung NSC(402;1.76e-12)|all_lung(304;1.3e-11)		GBM - Glioblastoma multiforme(35;5.17e-06)|BRCA - Breast invasive adenocarcinoma(625;0.00112)|Lung(87;0.153)		AGGGGCTCAGGAAGCTCCCGG	0.617			NA											22	35					1.9806e-07	2.45363e-07	0.002299	1	0
ARHGAP1	392	broad.mit.edu	37	11	46702914	46702914	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:46702914G>A	uc001ndd.2	-	6	534	c.465C>T	c.(463-465)ATC>ATT	p.I155I		NM_004308	NP_004299	Q07960	RHG01_HUMAN	Rho GTPase activating protein 1	155	CRAL-TRIO.				Rho protein signal transduction	cytosol|intracellular membrane-bounded organelle	SH3 domain binding|SH3/SH2 adaptor activity			skin(1)	1		Lung NSC(402;1.76e-12)|all_lung(304;1.3e-11)		GBM - Glioblastoma multiforme(35;5.17e-06)|BRCA - Breast invasive adenocarcinoma(625;0.00112)|Lung(87;0.153)		ACAAGGCCTTGATGTTTTTCT	0.517			NA											35	58					0	0	0.00623	0	0
F2	2147	broad.mit.edu	37	11	46750227	46750227	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:46750227A>T	uc001ndf.3	+	11	1355	c.1312A>T	c.(1312-1314)ATT>TTT	p.I438F	F2_uc001ndg.3_RNA	NM_000506	NP_000497	P00734	THRB_HUMAN	coagulation factor II preproprotein	438	Peptidase S1.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity			ovary(3)	3		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	CGAGCGAAACATTGAAAAGAT	0.532	Esophageal Squamous(147;1147 1808 2148 38609 51144)		NA											15	47					0	0	0.004007	0	0
OR4A16	81327	broad.mit.edu	37	11	55110788	55110788	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:55110788G>T	uc010rie.1	+	1	112	c.112G>T	c.(112-114)GTG>TTG	p.V38L		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	38	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						TGTGACAATGGTGGGAAACCT	0.423			NA											18	56					2.89027e-11	3.99594e-11	0.002299	1	0
OR4C15	81309	broad.mit.edu	37	11	55322514	55322514	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:55322514T>A	uc010rig.1	+	1	732	c.732T>A	c.(730-732)GAT>GAA	p.D244E		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	190	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CCTGCACTGATACTCACATCT	0.438			NA								HNSCC(20;0.049)			11	24					0	0	0.008291	0	0
OR4C16	219428	broad.mit.edu	37	11	55340052	55340052	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:55340052C>A	uc010rih.1	+	1	449	c.449C>A	c.(448-450)TCC>TAC	p.S150Y		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				TGGGTGGGATCCTGTGTGCAT	0.498			NA											26	64					4.26978e-12	6.0541e-12	0.00333	1	0
OR4C16	219428	broad.mit.edu	37	11	55340325	55340325	+	Missense_Mutation	SNP	A	A	T	rs146728227	by1000genomes	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:55340325A>T	uc010rih.1	+	1	722	c.722A>T	c.(721-723)CAC>CTC	p.H241L		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				TGTGTCTCCCACATCATTGTG	0.388			NA											15	35					0	0	0.00245	0	0
OR4P4	81300	broad.mit.edu	37	11	55406058	55406058	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:55406058G>A	uc010rij.1	+	1	225	c.225G>A	c.(223-225)GTG>GTA	p.V75V		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						CATCCACAGTGACCCCCAAAT	0.408			NA											20	80					0	0	0.008871	0	0
OR4S2	219431	broad.mit.edu	37	11	55418917	55418917	+	Missense_Mutation	SNP	C	C	G	rs140330182		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:55418917C>G	uc001nhs.1	+	1	538	c.538C>G	c.(538-540)CAC>GAC	p.H180D		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				TTGTGATGTTCACCCTGTGTT	0.453			NA											50	120					0	0	0.00361	0	0
OR4C6	219432	broad.mit.edu	37	11	55433261	55433261	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:55433261G>T	uc001nht.3	+	3	884	c.619G>T	c.(619-621)GCC>TCC	p.A207S	OR4C6_uc010rik.1_Missense_Mutation_p.A207S	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GATGTGTGTGGCCATCTTTCT	0.488			NA											23	46					9.95505e-16	1.55696e-15	0.002299	1	0
OR5L1	219437	broad.mit.edu	37	11	55578989	55578989	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:55578989G>T	uc001nhw.1	+	1	47	c.47G>T	c.(46-48)GGA>GTA	p.G16V		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				ATTCTCCTTGGACTATCAGAT	0.433			NA											32	129					9.14704e-12	1.29187e-11	0.00874	1	0
SPRYD5	84767	broad.mit.edu	37	11	55653694	55653694	+	Missense_Mutation	SNP	G	G	T	rs143260124		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:55653694G>T	uc010rip.1	+	3	599	c.507G>T	c.(505-507)AAG>AAT	p.K169N	SPRYD5_uc010riq.1_Missense_Mutation_p.K26N	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	169						intracellular	zinc ion binding				0		all_epithelial(135;0.226)				GATGCTGGAAGGTTAGTACCG	0.398			NA											21	40					6.21321e-17	9.97712e-17	0.00278	1	0
OR5T3	390154	broad.mit.edu	37	11	56019807	56019807	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:56019807G>T	uc010rjd.1	+	1	132	c.132G>T	c.(130-132)TTG>TTT	p.L44F		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	44	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					TGTTTATATTGACAGGCTTCA	0.363			NA											12	52					0.00136819	0.00147234	0.001368	1	0
OR5M11	219487	broad.mit.edu	37	11	56310441	56310441	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:56310441G>T	uc010rjl.1	-	1	293	c.293C>A	c.(292-294)ACA>AAA	p.T98K		NM_001005245	NP_001005245	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTAGCACTGTGTAAAGCAACC	0.448			NA											9	21					0.000442599	0.000483873	0.006214	1	0
OR5M11	219487	broad.mit.edu	37	11	56310563	56310563	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:56310563C>A	uc010rjl.1	-	1	171	c.171G>T	c.(169-171)ACG>ACT	p.T57T		NM_001005245	NP_001005245	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M,	57	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGTACATGGGCGTGTGAAGGC	0.458			NA											40	70					3.43241e-23	6.11055e-23	0.009718	1	0
OR9G9	504191	broad.mit.edu	37	11	56468342	56468342	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:56468342A>C	uc010rjn.1	+	1	479	c.479A>C	c.(478-480)AAG>ACG	p.K160T		NM_001013358	NP_001013376	P0C7N8	OR9G9_HUMAN	olfactory receptor, family 9, subfamily G,	160	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATCATCACCAAGAAAACGTTT	0.468			NA											6	113					0	0	0.001168	0	0
CLP1	10978	broad.mit.edu	37	11	57428834	57428834	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:57428834C>T	uc001nkw.2	+	3	1343	c.1204C>T	c.(1204-1206)CTG>TTG	p.L402L	CLP1_uc010rjw.1_Silent_p.L338L|CLP1_uc009yml.2_Silent_p.L402L	NM_006831	NP_006822	Q92989	CLP1_HUMAN	ATP/GTP-binding protein isoform 1	402					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			ovary(1)	1						GTTTACTGTTCTGTCTCCAGC	0.532			NA											12	75					0	0	0.001368	0	0
OR9I1	219954	broad.mit.edu	37	11	57886376	57886376	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:57886376G>A	uc001nml.1	-	1	541	c.541C>T	c.(541-543)CTC>TTC	p.L181F	OR9Q1_uc001nmj.2_Intron	NM_001005211	NP_001005211	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Breast(21;0.0589)				AGGGGTGGGAGGTCACAGAAG	0.488			NA											8	22					0	0	0.004482	0	0
OR9Q2	219957	broad.mit.edu	37	11	57958227	57958227	+	Missense_Mutation	SNP	G	G	A	rs142991971		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:57958227G>A	uc010rka.1	+	1	265	c.265G>A	c.(265-267)GGC>AGC	p.G89S		NM_001005283	NP_001005283	Q8NGE9	OR9Q2_HUMAN	olfactory receptor, family 9, subfamily Q,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)|central_nervous_system(1)	4		Breast(21;0.0589)				GTGGGAGCACGGCACAACCAT	0.572			NA											29	80					0	0	0.009535	0	0
OR9Q2	219957	broad.mit.edu	37	11	57958678	57958678	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:57958678C>A	uc010rka.1	+	1	716	c.716C>A	c.(715-717)TCC>TAC	p.S239Y		NM_001005283	NP_001005283	Q8NGE9	OR9Q2_HUMAN	olfactory receptor, family 9, subfamily Q,	239	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)|central_nervous_system(1)	4		Breast(21;0.0589)				AAGACCTTCTCCACCTGCGCC	0.567			NA											21	37					5.26018e-13	7.68508e-13	0.001882	1	0
OR5B3	441608	broad.mit.edu	37	11	58170490	58170490	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:58170490G>T	uc010rkf.1	-	1	393	c.393C>A	c.(391-393)ACC>ACA	p.T131T		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TCATGGTTGTGGTGTAATGTA	0.478			NA											22	58					8.10497e-08	1.01718e-07	0.010504	1	0
OR4D6	219983	broad.mit.edu	37	11	59224722	59224722	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:59224722T>G	uc010rku.1	+	1	289	c.289T>G	c.(289-291)TGC>GGC	p.C97G		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	97	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTACAATGACTGCATGGCACA	0.463			NA											38	101					0	0	0.007835	0	0
CCDC86	79080	broad.mit.edu	37	11	60609861	60609861	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:60609861C>T	uc001nqa.2	+	1	433	c.264C>T	c.(262-264)GGC>GGT	p.G88G	CCDC86_uc001nqb.2_5'UTR	NM_024098	NP_077003	Q9H6F5	CCD86_HUMAN	coiled-coil domain containing 86	88	Pro-rich.				interspecies interaction between organisms	nucleus					0						CAGAGCCAGGCGCAGCGTCCC	0.647			NA											12	51					0	0	0.001855	0	0
C11orf9	745	broad.mit.edu	37	11	61539178	61539178	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:61539178G>A	uc001nsc.1	+	6	1043	c.947G>A	c.(946-948)CGT>CAT	p.R316H	C11orf9_uc001nse.1_Missense_Mutation_p.R307H	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	316	NDT80.|Pro-rich.				central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						AGCATTGCCCGTGTCCAGACA	0.692			NA											33	81					0	0	0.004878	0	0
RPS6KA4	8986	broad.mit.edu	37	11	64135651	64135651	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:64135651G>T	uc001oae.2	+	10	1202	c.1119G>T	c.(1117-1119)GCG>GCT	p.A373A	RPS6KA4_uc001oad.2_Silent_p.A373A|RPS6KA4_uc010rnl.1_Silent_p.A310A|RPS6KA4_uc001oaf.2_Silent_p.A373A|RPS6KA4_uc009ypp.2_Intron|MIR1237_hsa-mir-1237|MI0006327_5'Flank	NM_003942	NP_003933	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	373					axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			lung(3)|ovary(1)|breast(1)	5						ACAACAACGCGGTGATGACCG	0.597			NA											17	54					1.67942e-08	2.14882e-08	0.006122	1	0
KLC2	64837	broad.mit.edu	37	11	66029663	66029663	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:66029663G>A	uc010rov.1	+	4	772	c.529G>A	c.(529-531)GCC>ACC	p.A177T	KLC2_uc010row.1_Missense_Mutation_p.A177T|KLC2_uc009yra.2_Missense_Mutation_p.A177T|KLC2_uc001ohb.2_Missense_Mutation_p.A177T|KLC2_uc010rox.1_Missense_Mutation_p.A100T|KLC2_uc001ohc.2_Missense_Mutation_p.A177T|KLC2_uc001ohd.2_Missense_Mutation_p.A100T|KLC2_uc001ohe.1_Missense_Mutation_p.A38T	NM_001134775	NP_001128247	Q9H0B6	KLC2_HUMAN	kinesin light chain 2 isoform 1	177					blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0						GCAGAGCCCAGGTGCGGATGG	0.572			NA											11	21					0	0	0.008291	0	0
CTSF	8722	broad.mit.edu	37	11	66335023	66335023	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:66335023G>A	uc001oip.2	-	3	513	c.423C>T	c.(421-423)TTC>TTT	p.F141F		NM_003793	NP_003784	Q9UBX1	CATF_HUMAN	cathepsin F precursor	141					proteolysis	lysosome	cysteine-type endopeptidase activity				0						AGCCCTGAGTGAAGGCTGACT	0.547			NA											27	81					0	0	0.00632	0	0
CCDC87	55231	broad.mit.edu	37	11	66358707	66358707	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:66358707C>A	uc001oiq.3	-	1	1848	c.1780G>T	c.(1780-1782)GTG>TTG	p.V594L	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	594										ovary(1)|skin(1)	2						TAGTCATCCACAGACAAGGTG	0.468			NA											29	80					6.38683e-12	9.04697e-12	0.008361	1	0
MRPL21	219927	broad.mit.edu	37	11	68660871	68660871	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:68660871C>A	uc001ooi.2	-	5	474	c.449G>T	c.(448-450)GGA>GTA	p.G150V	MRPL21_uc001ooh.2_Missense_Mutation_p.G65V|MRPL21_uc010rqe.1_Missense_Mutation_p.G150V	NM_181514	NP_852615	Q7Z2W9	RM21_HUMAN	mitochondrial ribosomal protein L21 isoform d	150					translation	mitochondrion|ribosome	RNA binding|structural constituent of ribosome				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CAGCCATTACCCGAGGAGTGG	0.532			NA											16	28					5.45024e-15	8.38767e-15	0.00333	1	0
TPCN2	219931	broad.mit.edu	37	11	68846201	68846201	+	Splice_Site	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:68846201G>A	uc001oos.2	+	15	1467	c.1351_splice	c.e15-1	p.V451_splice	TPCN2_uc009ysk.1_Splice_Site|TPCN2_uc001oor.2_Splice_Site_p.V366_splice|TPCN2_uc010rqg.1_Splice_Site_p.V451_splice|TPCN2_uc001oot.2_Splice_Site	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2						cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TGGCGTTGCAGGTGTTCCTGG	0.657			NA											5	57					0	0	0.001984	0	0
TPCN2	219931	broad.mit.edu	37	11	68851461	68851461	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:68851461C>T	uc001oos.2	+	19	1854	c.1738C>T	c.(1738-1740)CGT>TGT	p.R580C	TPCN2_uc010rqg.1_Intron|TPCN2_uc001oot.2_RNA	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	580	Cytoplasmic (Potential).				cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GCAGAACATGCGTGCGTTTGG	0.662			NA											14	42					0	0	0.00499	0	0
FOLR2	2350	broad.mit.edu	37	11	71929695	71929695	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:71929695G>T	uc009ytd.2	+	2	236	c.67G>T	c.(67-69)GAC>TAC	p.D23Y	FOLR2_uc009yte.2_Missense_Mutation_p.D23Y|FOLR2_uc001ose.3_Missense_Mutation_p.D23Y|FOLR2_uc009ytf.2_Missense_Mutation_p.D23Y	NM_001113534	NP_001107006	P14207	FOLR2_HUMAN	folate receptor 2 precursor	23					folic acid transport	anchored to membrane|extracellular region|membrane fraction|plasma membrane	folic acid binding|receptor activity			breast(2)|ovary(1)	3					Folic Acid(DB00158)	CAGTGCCCAGGACAGGACTGA	0.552			NA											4	18					0.000602214	0.000654897	0.000602	1	0
UVRAG	7405	broad.mit.edu	37	11	75852056	75852056	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:75852056G>T	uc001oxc.2	+	15	1940	c.1699G>T	c.(1699-1701)GAT>TAT	p.D567Y	UVRAG_uc010rrw.1_Missense_Mutation_p.D466Y|UVRAG_uc001oxd.2_Missense_Mutation_p.D195Y|UVRAG_uc010rrx.1_Missense_Mutation_p.D195Y|UVRAG_uc010rry.1_Missense_Mutation_p.D123Y	NM_003369	NP_003360	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	567					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			skin(4)|lung(2)	6						AAAAGGAGAGGATCTAGTTGG	0.527			NA											8	26					0.00448238	0.0047387	0.004482	1	0
RAB38	23682	broad.mit.edu	37	11	87883020	87883020	+	Silent	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:87883020T>A	uc001pcj.1	-	2	353	c.306A>T	c.(304-306)GCA>GCT	p.A102A		NM_022337	NP_071732	P57729	RAB38_HUMAN	RAB38	102					protein transport|small GTPase mediated signal transduction	melanosome|plasma membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TTTTCCACTTTGCCACTGCTT	0.453			NA											63	103					0	0	0.00361	0	0
TYR	7299	broad.mit.edu	37	11	88961112	88961112	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:88961112C>G	uc001pcs.2	+	3	1240	c.1158C>G	c.(1156-1158)TTC>TTG	p.F386L		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	386	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	ATCCTATCTTCCTTCTTCACC	0.408			NA							Oculocutaneous_Albinism				31	35					0	0	0.002445	0	0
FOLH1B	219595	broad.mit.edu	37	11	89402584	89402584	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:89402584G>T	uc001pda.2	+	3	534	c.8G>T	c.(7-9)GGC>GTC	p.G3V		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	3					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						AAAATGGGTGGCTCAGCACCA	0.388			NA											10	34					0.00136819	0.00147234	0.001368	1	0
FAT3	120114	broad.mit.edu	37	11	92532563	92532563	+	Silent	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:92532563C>G	uc001pdj.3	+	9	6401	c.6384C>G	c.(6382-6384)GGC>GGG	p.G2128G		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2128	Cadherin 19.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATGACTATGGCCACTTTGAAA	0.438			NA								TCGA Ovarian(4;0.039)			3	8					0	0	0.004672	0	0
C11orf54	28970	broad.mit.edu	37	11	93492964	93492964	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:93492964G>T	uc009ywi.2	+	9	1045	c.714G>T	c.(712-714)TTG>TTT	p.L238F	C11orf54_uc001pee.1_Missense_Mutation_p.L179F|C11orf54_uc001pef.2_Missense_Mutation_p.L188F|C11orf54_uc001peg.2_Missense_Mutation_p.L238F|C11orf54_uc001peh.2_Missense_Mutation_p.L238F|C11orf54_uc001pei.2_Missense_Mutation_p.L219F|C11orf54_uc001pej.2_Missense_Mutation_p.L219F|C11orf54_uc001pek.2_Missense_Mutation_p.L127F	NM_014039	NP_054758	Q9H0W9	CK054_HUMAN	hypothetical protein LOC28970	238						nucleus	hydrolase activity, acting on ester bonds|protein binding|zinc ion binding				0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				ATAAATGGTTGCATTTTTATG	0.338			NA											28	75					3.65163e-15	5.65591e-15	0.00632	1	0
PGR	5241	broad.mit.edu	37	11	100998878	100998878	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:100998878G>C	uc001pgh.2	-	1	1667	c.924C>G	c.(922-924)ATC>ATG	p.I308M	PGR_uc001pgi.2_Missense_Mutation_p.I308M|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA|uc010rum.1_5'Flank	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	308	Modulating, Pro-Rich.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	TGAGAGGCAGGATAGGCACGT	0.687	Pancreas(124;2271 2354 21954 22882)		NA											6	14					0	0	0.001984	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103128397	103128397	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:103128397G>T	uc001pho.2	+	69	10666	c.10522G>T	c.(10522-10524)GAT>TAT	p.D3508Y	DYNC2H1_uc001phn.1_Missense_Mutation_p.D3515Y|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3508					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CATTATTTCTGATTTGTCCAA	0.438			NA											7	16					0.00198382	0.00212531	0.001984	1	0
TTC12	54970	broad.mit.edu	37	11	113235745	113235745	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:113235745G>T	uc001pnu.2	+	21	2110	c.2005G>T	c.(2005-2007)GGC>TGC	p.G669C	TTC12_uc001pnv.2_Missense_Mutation_p.G675C|TTC12_uc001pnw.2_RNA|TTC12_uc001pnx.2_Missense_Mutation_p.G519C	NM_017868	NP_060338	Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	669							binding			pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		GGTGAACGCAGGCATTGCTCT	0.572			NA											8	21					0.00307968	0.003275	0.00308	1	0
FAM55A	120400	broad.mit.edu	37	11	114393655	114393655	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:114393655G>A	uc001ppa.2	-	5	1045	c.628C>T	c.(628-630)CTG>TTG	p.L210L	FAM55A_uc010rxd.1_Silent_p.L59L	NM_152315	NP_689528	Q8N323	FA55A_HUMAN	hypothetical protein LOC120400	352						extracellular region					0		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;3.02e-06)|Epithelial(105;0.000144)|all cancers(92;0.00106)		GAGTCTCCCAGGAGGTAAATG	0.353			NA											22	26					0	0	0.003954	0	0
VPS11	55823	broad.mit.edu	37	11	118940016	118940016	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:118940016G>T	uc010ryx.1	+	3	340	c.298G>T	c.(298-300)GCA>TCA	p.A100S	VPS11_uc010ryy.1_5'UTR	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	100					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		CAATATTCTGGCATCTGTTGG	0.493			NA											22	44					1.64293e-13	2.43987e-13	0.00333	1	0
ABCG4	64137	broad.mit.edu	37	11	119027100	119027100	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:119027100G>A	uc001pvs.2	+	7	1084	c.748G>A	c.(748-750)GGC>AGC	p.G250S	ABCG4_uc009zar.2_Missense_Mutation_p.G250S	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	250	Cytoplasmic (Potential).|ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GGCACAGGGGGGCCGTACCAT	0.587			NA											42	104					0	0	0.007835	0	0
OR8B12	219858	broad.mit.edu	37	11	124412749	124412749	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:124412749C>G	uc010sam.1	-	1	802	c.802G>C	c.(802-804)GAG>CAG	p.E268Q		NM_001005195	NP_001005195	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		TTCCCTTGCTCGAGGGGCAGG	0.438			NA											17	46					0	0	0.004007	0	0
PKNOX2	63876	broad.mit.edu	37	11	125300009	125300009	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:125300009G>T	uc001qbu.2	+	12	1478	c.1164G>T	c.(1162-1164)CAG>CAT	p.Q388H	PKNOX2_uc010saz.1_Missense_Mutation_p.Q359H|PKNOX2_uc010sba.1_Missense_Mutation_p.Q359H|PKNOX2_uc010sbb.1_Missense_Mutation_p.Q324H|PKNOX2_uc001qbv.2_Missense_Mutation_p.Q153H	NM_022062	NP_071345	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	388						nucleus	sequence-specific DNA binding transcription factor activity	p.Q388Q(1)		ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		TGCAGCAGCAGGGCGGTGCCC	0.622			NA											18	36					2.48551e-13	3.65724e-13	0.00499	1	0
FOXRED1	55572	broad.mit.edu	37	11	126144846	126144846	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:126144846G>A	uc001qdi.2	+	5	608	c.561G>A	c.(559-561)CTG>CTA	p.L187L	FOXRED1_uc010sbn.1_Silent_p.L17L|FOXRED1_uc010sbo.1_Intron|FOXRED1_uc010sbp.1_5'UTR|FOXRED1_uc010sbq.1_Silent_p.L54L|FOXRED1_uc001qdj.2_Intron|FOXRED1_uc010sbr.1_Silent_p.L173L|FOXRED1_uc001qdk.2_Intron	NM_017547	NP_060017	Q96CU9	FXRD1_HUMAN	FAD-dependent oxidoreductase domain containing	187						integral to membrane|mitochondrion	oxidoreductase activity|protein binding				0	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)		AAGTTTCTCTGATGTCTCCTG	0.527			NA											5	48					0	0	0.001984	0	0
NFRKB	4798	broad.mit.edu	37	11	129745269	129745269	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:129745269C>G	uc001qfi.2	-	18	2038	c.1837G>C	c.(1837-1839)GAT>CAT	p.D613H	NFRKB_uc001qfg.2_Missense_Mutation_p.D638H|NFRKB_uc001qfh.2_Missense_Mutation_p.D636H|NFRKB_uc010sbw.1_Missense_Mutation_p.D623H|NFRKB_uc009zcr.2_5'Flank	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	613					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		CTGGTGACATCTGGTGCAAGA	0.373			NA											5	9					0	0	0.001168	0	0
APLP2	334	broad.mit.edu	37	11	129996639	129996639	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:129996639G>T	uc010sby.1	+	8	1292	c.1135G>T	c.(1135-1137)GAG>TAG	p.E379*	APLP2_uc001qfp.2_Nonsense_Mutation_p.E379*|APLP2_uc001qfq.2_Nonsense_Mutation_p.E323*|APLP2_uc010sbz.1_Nonsense_Mutation_p.E167*|APLP2_uc001qfr.2_Nonsense_Mutation_p.E145*|APLP2_uc001qfs.2_Nonsense_Mutation_p.E150*|APLP2_uc001qfv.2_Nonsense_Mutation_p.E270*	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	379	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		TGTGTATTTCGAGACCTCTGC	0.483			NA											70	151					1.74474e-33	3.27594e-33	0.00361	1	0
SNX19	399979	broad.mit.edu	37	11	130784380	130784380	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:130784380C>A	uc001qgk.3	-	1	2003	c.1455G>T	c.(1453-1455)AAG>AAT	p.K485N	SNX19_uc010sce.1_Intron|SNX19_uc010scf.1_Intron|SNX19_uc010scg.1_Intron|SNX19_uc001qgl.3_Missense_Mutation_p.K485N|SNX19_uc009zcx.1_Intron	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	485					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		TGGTGAGATCCTTCTCTAAGC	0.537			NA											25	57					9.57634e-11	1.30768e-10	0.00333	1	0
CCDC77	84318	broad.mit.edu	37	12	547537	547537	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:547537C>T	uc001qig.2	+	10	1038	c.858C>T	c.(856-858)ACC>ACT	p.T286T	CCDC77_uc009zdk.2_Silent_p.T254T|CCDC77_uc010sdp.1_Silent_p.T254T|CCDC77_uc010sdq.1_Silent_p.T254T	NM_032358	NP_115734	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77 isoform a	286	Potential.					centrosome				ovary(1)	1	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			ATGAGAGCACCAAAGATTTTC	0.393			NA											23	35					0	0	0.004656	0	0
RAD51AP1	10635	broad.mit.edu	37	12	4657984	4657984	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:4657984G>C	uc001qmw.2	+	7	745	c.589G>C	c.(589-591)GAA>CAA	p.E197Q	RAD51AP1_uc001qmu.2_Missense_Mutation_p.E180Q|RAD51AP1_uc001qmv.2_Missense_Mutation_p.E143Q|RAD51AP1_uc010sep.1_Missense_Mutation_p.E62Q|RAD51AP1_uc010seq.1_Missense_Mutation_p.E62Q|RAD51AP1_uc009zeg.2_5'Flank	NM_001130862	NP_001124334	Q96B01	R51A1_HUMAN	RAD51 associated protein 1 isoform a	197					double-strand break repair via homologous recombination		double-stranded DNA binding|protein binding|protein binding|RNA binding|single-stranded DNA binding				0			Colorectal(7;0.00306)|COAD - Colon adenocarcinoma(12;0.0389)			TAATGACACTGAACCAGACTT	0.408			NA											38	50					0	0	0.00623	0	0
GALNT8	26290	broad.mit.edu	37	12	4873214	4873214	+	Splice_Site	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:4873214G>C	uc001qne.1	+	9	1685	c.1593_splice	c.e9+1	p.Q531_splice		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8							Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						CAGCTCACAGGTATCTTCCAC	0.522	Colon(108;631 1558 7270 20097 39846)		NA											10	46					0	0	0.008291	0	0
GNB3	2784	broad.mit.edu	37	12	6953059	6953059	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:6953059G>T	uc001qrd.2	+	9	1021	c.616G>T	c.(616-618)GCC>TCC	p.A206S	GNB3_uc001qrc.2_Missense_Mutation_p.A162S|GNB3_uc009zfe.2_Missense_Mutation_p.A205S	NM_002075	NP_002066	P16520	GBB3_HUMAN	guanine nucleotide-binding protein, beta-3	206	WD 4.				cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity				0						GGCCTGTGATGCCAGTGCCAA	0.582			NA											30	50					8.88839e-20	1.50612e-19	0.002096	1	0
CD163	9332	broad.mit.edu	37	12	7640054	7640054	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:7640054G>A	uc001qsz.3	-	8	2079	c.1951C>T	c.(1951-1953)CAC>TAC	p.H651Y	CD163_uc001qta.3_Missense_Mutation_p.H651Y|CD163_uc009zfw.2_Missense_Mutation_p.H684Y	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	651	SRCR 6.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						CCAGTGCAGTGAAACATATGC	0.493			NA											12	67					0	0	0.000978	0	0
DDX12	440081	broad.mit.edu	37	12	9571526	9571526	+	Splice_Site	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:9571526C>A	uc010sgs.1	-	26	2732	c.2537_splice	c.e26-1	p.G846_splice	DDX12_uc001qvx.3_Splice_Site_p.G68_splice|DDX12_uc001qvy.1_3'UTR	NM_004400	NP_004391			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12												0						ATGGCCCTGCCTGCATAGGAA	0.622			NA											12	11					4.36969e-10	5.83435e-10	0.001855	1	0
KIAA1467	57613	broad.mit.edu	37	12	13208570	13208570	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:13208570G>A	uc001rbi.2	+	2	146	c.123G>A	c.(121-123)CTG>CTA	p.L41L	KIAA1467_uc009zhx.1_RNA	NM_020853	NP_065904	A2RU67	K1467_HUMAN	hypothetical protein LOC57613	41						integral to membrane				central_nervous_system(2)|skin(1)	3		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		TGCTTAACCTGCAGAAGAATG	0.507			NA											20	50					0	0	0.008871	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18650569	18650569	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:18650569G>T	uc001rdt.2	+	21	2896	c.2780G>T	c.(2779-2781)CGT>CTT	p.R927L	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.R968L|PIK3C2G_uc010sic.1_Missense_Mutation_p.R746L	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	927	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				GATGATCTTCGTCAGGATATG	0.363			NA											15	29					5.3912e-06	6.29483e-06	0.006122	1	0
PDE3A	5139	broad.mit.edu	37	12	20807013	20807013	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:20807013G>A	uc001reh.1	+	15	3080	c.3058G>A	c.(3058-3060)GGA>AGA	p.G1020R		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	1020	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	TGATTCAGCAGGACTAATGCC	0.507			NA											18	42					0	0	0.006122	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27787932	27787932	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:27787932G>T	uc001ric.1	+	4	531	c.154G>T	c.(154-156)GTG>TTG	p.V52L	PPFIBP1_uc001rhy.1_Missense_Mutation_p.V52L|PPFIBP1_uc001rhz.1_Missense_Mutation_p.V52L|PPFIBP1_uc010sjr.1_Intron|PPFIBP1_uc001rib.1_Missense_Mutation_p.V52L|PPFIBP1_uc001ria.2_Missense_Mutation_p.V52L|PPFIBP1_uc001rid.1_Intron	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	52					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					TCTGCACCTTGTGGAAGACCT	0.448			NA											27	61					3.73148e-12	5.32751e-12	0.007291	1	0
MRPS35	60488	broad.mit.edu	37	12	27908184	27908184	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:27908184C>T	uc001rih.2	+	8	821	c.773C>T	c.(772-774)TCA>TTA	p.S258L	MRPS35_uc001rii.2_3'UTR	NM_021821	NP_068593	P82673	RT35_HUMAN	mitochondrial ribosomal protein S35 precursor	258	Potential.				DNA damage response, detection of DNA damage	mitochondrial small ribosomal subunit					0	Lung SC(9;0.0873)					AATAGCTCATCAGAAAGAAAT	0.333			NA											16	90					0	0	0.004007	0	0
Unknown	0	broad.mit.edu	37	12	31288990	31288990	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:31288990G>T	uc010sjy.1	-	17	2331	c.2331C>A	c.(2329-2331)TCC>TCA	p.S777S						RecName: Full=Ovostatin homolog 1; Flags: Precursor;												NA						AGAAAGGTTGGGAGACTTCTA	0.418			NA											6	11					5.9392e-07	7.17882e-07	0.001168	1	0
LRRK2	120892	broad.mit.edu	37	12	40697792	40697792	+	Silent	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:40697792A>T	uc001rmg.3	+	27	3754	c.3633A>T	c.(3631-3633)CTA>CTT	p.L1211L	LRRK2_uc001rmh.1_Silent_p.L833L|LRRK2_uc009zjw.2_Silent_p.L49L|LRRK2_uc001rmi.2_Silent_p.L44L	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1211	LRR 9.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTCAGTACCTACCAGGTCCCG	0.358			NA											35	49					0	0	0.00874	0	0
PDZRN4	29951	broad.mit.edu	37	12	41585260	41585260	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:41585260G>C	uc010skn.1	+	2	120	c.52G>C	c.(52-54)GAT>CAT	p.D18H		NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	217							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TTTTTTCTAGGATGGAGAGCA	0.303			NA											9	46					0	0	0.006214	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43777690	43777690	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:43777690G>C	uc010skx.1	-	30	4543	c.4543C>G	c.(4543-4545)CAG>GAG	p.Q1515E		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1515	TSP type-1 12.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CGGGTGGACTGATCACACATT	0.507			NA											34	66					0	0	0.003271	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43945646	43945646	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:43945646G>C	uc010skx.1	-	1	79	c.79C>G	c.(79-81)CAC>GAC	p.H27D		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	27						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TGCCTGGGGTGGAAGTCAACT	0.647			NA											33	38					0	0	0.002836	0	0
NELL2	4753	broad.mit.edu	37	12	44913879	44913879	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:44913879G>T	uc001rog.2	-	19	2904	c.2309C>A	c.(2308-2310)ACC>AAC	p.T770N	NELL2_uc001rof.3_Missense_Mutation_p.T769N|NELL2_uc001roh.2_Missense_Mutation_p.T770N|NELL2_uc009zkd.2_Missense_Mutation_p.T722N|NELL2_uc010skz.1_Missense_Mutation_p.T820N|NELL2_uc010sla.1_Missense_Mutation_p.T793N	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	770	VWFC 5.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		GCAAGTCTTGGTGATGTCATT	0.532			NA											12	64					3.07112e-06	3.6122e-06	0.000978	1	0
COL2A1	1280	broad.mit.edu	37	12	48377872	48377872	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:48377872C>G	uc001rqu.2	-	29	2120	c.1939G>C	c.(1939-1941)GCT>CCT	p.A647P	COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Missense_Mutation_p.A578P	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	647	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	GTACTTACAGCAGGGCCAGGG	0.582			NA											8	20					0	0	0.008291	0	0
WNT10B	7480	broad.mit.edu	37	12	49361734	49361734	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:49361734G>T	uc001rss.2	-	4	1052	c.706C>A	c.(706-708)CGC>AGC	p.R236S	WNT10B_uc001rst.2_Silent_p.G188G	NM_003394	NP_003385	O00744	WN10B_HUMAN	wingless-type MMTV integration site family,	236					axis specification|bone trabecula formation|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|chondrocyte differentiation|female gonad development|hemopoietic stem cell proliferation|midbrain-hindbrain boundary development|myoblast cell differentiation involved in skeletal muscle regeneration|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|neuron differentiation|positive regulation of anagen|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cell proliferation|positive regulation of epithelial cell differentiation|positive regulation of osteoblast differentiation|protein stabilization|regulation of skeletal muscle tissue development|skeletal muscle fiber development|smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			skin(4)|lung(3)	7						CATACCTGGCGCCCCACCCTG	0.517			NA											16	28					2.62699e-14	3.97911e-14	0.003163	1	0
WNT10B	7480	broad.mit.edu	37	12	49361936	49361936	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:49361936G>T	uc001rss.2	-	4	850	c.504C>A	c.(502-504)TCC>TCA	p.S168S	WNT10B_uc001rst.2_Silent_p.S168S	NM_003394	NP_003385	O00744	WN10B_HUMAN	wingless-type MMTV integration site family,	168					axis specification|bone trabecula formation|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|chondrocyte differentiation|female gonad development|hemopoietic stem cell proliferation|midbrain-hindbrain boundary development|myoblast cell differentiation involved in skeletal muscle regeneration|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|neuron differentiation|positive regulation of anagen|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cell proliferation|positive regulation of epithelial cell differentiation|positive regulation of osteoblast differentiation|protein stabilization|regulation of skeletal muscle tissue development|skeletal muscle fiber development|smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			skin(4)|lung(3)	7						TCTTGCCTCGGGACAGTGCCT	0.507			NA											17	30					2.35188e-11	3.27673e-11	0.006122	1	0
DDN	23109	broad.mit.edu	37	12	49390588	49390588	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:49390588C>G	uc001rsv.1	-	2	2089	c.2071G>C	c.(2071-2073)GAG>CAG	p.E691Q	uc001rsw.2_5'Flank	NM_015086	NP_055901	O94850	DEND_HUMAN	dendrin	691	Interaction with CD2AP and NPHS1 (By similarity).					dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				large_intestine(1)	1						AGGACCTCCTCGGTTTGGCTT	0.562			NA									OREG0021778	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	94					0	0	0.00245	0	0
DDN	23109	broad.mit.edu	37	12	49390664	49390664	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:49390664A>C	uc001rsv.1	-	2	2013	c.1995T>G	c.(1993-1995)AGT>AGG	p.S665R	uc001rsw.2_5'Flank	NM_015086	NP_055901	O94850	DEND_HUMAN	dendrin	665	Interaction with CD2AP and NPHS1 (By similarity).					dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				large_intestine(1)	1						CCTCTGGCGAACTGTTTCCAA	0.607			NA									OREG0021778	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	39					0	0	0.004672	0	0
KCNH3	23416	broad.mit.edu	37	12	49937805	49937805	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:49937805G>A	uc001ruh.1	+	6	1191	c.931G>A	c.(931-933)GTC>ATC	p.V311I	KCNH3_uc010smj.1_Missense_Mutation_p.V251I	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	311	Helical; Name=Segment S3; (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						CCTGCTGGATGTCATCGCAGC	0.597			NA											44	96					0	0	0.00361	0	0
LASS5	91012	broad.mit.edu	37	12	50528463	50528463	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:50528463C>G	uc001rwd.3	-	9	912	c.895G>C	c.(895-897)GAG>CAG	p.E299Q	LASS5_uc001rwc.2_Missense_Mutation_p.E218Q|LASS5_uc001rwe.3_Missense_Mutation_p.E240Q|LASS5_uc001rwf.3_RNA|LASS5_uc010smq.1_Missense_Mutation_p.E155Q	NM_147190	NP_671723	Q8N5B7	CERS5_HUMAN	LAG1 homolog, ceramide synthase 5	299	TLC.|Cytoplasmic (Potential).				ceramide biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0						TCCCAACTCTCAAAGAGGGTC	0.512			NA											37	101					0	0	0.005524	0	0
POU6F1	5463	broad.mit.edu	37	12	51584375	51584375	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:51584375C>A	uc001rxy.2	-	5	753	c.561G>T	c.(559-561)CGG>CGT	p.R187R	POU6F1_uc001rxz.2_Silent_p.R187R|POU6F1_uc001rya.2_Silent_p.R187R	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	187	POU-specific.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCTTCTCGAACCTGTGGGCAA	0.582			NA											56	64					1.0442e-30	1.94288e-30	0.00361	1	0
SCN8A	6334	broad.mit.edu	37	12	52201157	52201157	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:52201157G>A	uc001ryw.2	+	27	6065	c.5887G>A	c.(5887-5889)GAA>AAA	p.E1963K	uc001rzb.1_5'Flank	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1963					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	GCGGGCAGAGGAAGGAAGAAG	0.453			NA											9	19					0	0	0.004482	0	0
ACVRL1	94	broad.mit.edu	37	12	52309904	52309904	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:52309904C>A	uc001rzj.2	+	8	1416	c.1133C>A	c.(1132-1134)CCC>CAC	p.P378H	ACVRL1_uc001rzk.2_Missense_Mutation_p.P378H|ACVRL1_uc010snm.1_Missense_Mutation_p.P204H	NM_000020	NP_000011	P37023	ACVL1_HUMAN	activin A receptor type II-like 1 precursor	378	Cytoplasmic (Potential).|Protein kinase.		P -> L (in HHT2; retained in the cell cytoplasm in the endoplasmic reticulum).		blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	TACATGGCACCCGAGGTGCTG	0.627			NA							Hereditary_Hemorrhagic_Telangiectasia				42	65					8.20599e-20	1.3954e-19	0.002852	1	0
KRT84	3890	broad.mit.edu	37	12	52777468	52777468	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:52777468G>A	uc001sah.1	-	2	709	c.661C>T	c.(661-663)CTG>TTG	p.L221L		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	keratin, hair, basic, 4	221	Rod.|Coil 1B.					keratin filament	structural constituent of epidermis			skin(1)	1	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TGCCTCCGCAGGTTGGTGATG	0.547			NA											12	42					0	0	0.00632	0	0
KRT82	3888	broad.mit.edu	37	12	52799947	52799947	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:52799947G>T	uc001sai.1	-	1	230	c.115C>A	c.(115-117)CGG>AGG	p.R39R		NM_033033	NP_149022	Q9NSB4	KRT82_HUMAN	keratin 82	39	Head.					keratin filament	protein binding|structural constituent of epidermis			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.193)		CCCCCGGGCCGGCATGGCCCC	0.657			NA											12	19					1.5842e-08	2.03602e-08	0.001855	1	0
KRT72	140807	broad.mit.edu	37	12	52985332	52985332	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:52985332G>C	uc001sar.2	-	5	965	c.879C>G	c.(877-879)GAC>GAG	p.D293E	KRT72_uc001saq.2_Missense_Mutation_p.D293E|KRT72_uc010sns.1_Missense_Mutation_p.D293E|KRT72_uc010snt.1_Missense_Mutation_p.D105E	NM_001146225	NP_001139697	Q14CN4	K2C72_HUMAN	keratin 72 isoform 1	293	Linker 12.|Rod.					keratin filament	structural molecule activity			ovary(5)|pancreas(1)	6				BRCA - Breast invasive adenocarcinoma(357;0.195)		CAATGATGCTGTCCAGGTCCA	0.597			NA											30	46					0	0	0.007291	0	0
KRT79	338785	broad.mit.edu	37	12	53217717	53217717	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:53217717C>A	uc001sbb.2	-	6	1133	c.1100G>T	c.(1099-1101)CGC>CTC	p.R367L	KRT79_uc001sba.2_Missense_Mutation_p.R138L	NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	367	Rod.|Coil 2.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						CTGGATAGTGCGGGTGAGCTC	0.607			NA											15	32					6.94344e-10	9.19416e-10	0.006122	1	0
NCKAP1L	3071	broad.mit.edu	37	12	54929927	54929927	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:54929927G>T	uc001sgc.3	+	28	3050	c.2971G>T	c.(2971-2973)GAG>TAG	p.E991*	NCKAP1L_uc010sox.1_Nonsense_Mutation_p.E533*|NCKAP1L_uc010soy.1_Nonsense_Mutation_p.E941*	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	991					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						TTCATCTCCTGAGGAGGAATA	0.418			NA											35	53					1.07637e-12	1.55523e-12	0.004878	1	0
OR9K2	441639	broad.mit.edu	37	12	55523708	55523708	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:55523708C>A	uc010spe.1	+	1	156	c.156C>A	c.(154-156)CTC>CTA	p.L52L		NM_001005243	NP_001005243	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K,	52	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						ACATTCTCCTCTTCCTGCTAT	0.448			NA											74	110					5.61366e-43	1.07502e-42	0.00361	1	0
ITGA7	3679	broad.mit.edu	37	12	56096669	56096669	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:56096669C>A	uc001shh.2	-	3	621	c.401G>T	c.(400-402)GGG>GTG	p.G134V	ITGA7_uc001shg.2_Missense_Mutation_p.G134V|ITGA7_uc010sps.1_Intron|ITGA7_uc009znx.2_Missense_Mutation_p.G21V	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	134	FG-GAP 2.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						AATCTTGCCCCCAGGCCCCTG	0.403			NA											25	47					1.26454e-06	1.51703e-06	0.005443	1	0
ESYT1	23344	broad.mit.edu	37	12	56531325	56531325	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:56531325G>A	uc001sjq.2	+	18	2031	c.1981G>A	c.(1981-1983)GCC>ACC	p.A661T	ESYT1_uc001sjr.2_Missense_Mutation_p.A671T	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	661	C2 3.					integral to membrane				ovary(4)|skin(1)	5						GGACCTGATTGCCAAAGACCG	0.547			NA											56	244					0	0	0.00361	0	0
STAT2	6773	broad.mit.edu	37	12	56748643	56748643	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:56748643C>T	uc001slc.2	-	7	630	c.552G>A	c.(550-552)AAG>AAA	p.K184K	STAT2_uc001sld.2_Silent_p.K180K|STAT2_uc010sqn.1_Silent_p.K180K	NM_005419	NP_005410	P52630	STAT2_HUMAN	signal transducer and activator of transcription	184					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						GAGAGGGTGTCTTCCCTGGAT	0.522			NA											22	144					0	0	0.010504	0	0
STAT2	6773	broad.mit.edu	37	12	56750051	56750052	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:56750051_56750052CC>AA	uc001slc.2	-	3	227_228	c.149_150GG>TT	c.(148-150)GGG>GTT	p.G50V	STAT2_uc001sld.2_Missense_Mutation_p.G50V|STAT2_uc010sqn.1_Missense_Mutation_p.G50V	NM_005419	NP_005410	P52630	STAT2_HUMAN	signal transducer and activator of transcription	50					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						AATCATCACTCCCAAGTGCAGC	0.505			NA											18	41					0	0	0.004672	0	0
SLC26A10	65012	broad.mit.edu	37	12	58018936	58018936	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:58018936G>A	uc001spe.2	+	11	1686	c.1375G>A	c.(1375-1377)GCA>ACA	p.A459T	SLC26A10_uc001spf.2_RNA|SLC26A10_uc009zpz.1_RNA	NM_133489	NP_597996	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	459	STAS.					integral to membrane	antiporter activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					CCCAATGGTTGCAGGTGAGAT	0.512			NA											87	195					0	0	0.00361	0	0
FAM19A2	338811	broad.mit.edu	37	12	62261137	62261137	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:62261137A>T	uc001sqw.2	-	2	1583	c.70T>A	c.(70-72)TGG>AGG	p.W24R	FAM19A2_uc001sqx.2_Missense_Mutation_p.W24R|FAM19A2_uc001sqy.2_RNA	NM_178539	NP_848634	Q8N3H0	F19A2_HUMAN	family with sequence similarity 19 (chemokine	24						cytoplasm				ovary(1)	1			GBM - Glioblastoma multiforme(1;0.00484)	GBM - Glioblastoma multiforme(3;0.02)		ACTTTCCCCCACAAGGTTACA	0.303			NA											47	75					0	0	0.00361	0	0
CAND1	55832	broad.mit.edu	37	12	67696315	67696315	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:67696315A>T	uc001stn.2	+	8	1650	c.1213A>T	c.(1213-1215)ACT>TCT	p.T405S	CAND1_uc001sto.2_Missense_Mutation_p.T83S	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	405	HEAT 9.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		TTTGAAGCAAACTCGTCCTGT	0.418			NA											69	26					0	0	0.00361	0	0
CCT2	10576	broad.mit.edu	37	12	69991453	69991453	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:69991453C>G	uc001svb.1	+	12	1232	c.1138C>G	c.(1138-1140)CAA>GAA	p.Q380E	CCT2_uc009zrm.1_RNA|CCT2_uc009zrn.1_Missense_Mutation_p.Q380E|CCT2_uc010stl.1_Missense_Mutation_p.Q333E	NM_006431	NP_006422	P78371	TCPB_HUMAN	chaperonin containing TCP1, subunit 2	380					'de novo' posttranslational protein folding	nucleus	ATP binding|unfolded protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(2;7.7e-106)|Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.72e-18)|GBM - Glioblastoma multiforme(2;2.58e-10)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			TGGTGCCACTCAACAAATTTT	0.393			NA											17	78					0	0	0.006122	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72013875	72013875	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:72013875G>A	uc001swo.2	-	26	5239	c.4880C>T	c.(4879-4881)TCT>TTT	p.S1627F		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	1627	TPR 3.				RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						TTCCAATAAAGATTTACAAAG	0.363			NA											22	7					0	0	0.002299	0	0
TRHDE	29953	broad.mit.edu	37	12	72771835	72771835	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:72771835A>G	uc001sxa.2	+	3	1144	c.1114A>G	c.(1114-1116)ATA>GTA	p.I372V		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	372	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						TGCTCTCCATATAACAAAGAG	0.328			NA											29	46					0	0	0.009535	0	0
KCNC2	3747	broad.mit.edu	37	12	75601717	75601717	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:75601717C>A	uc001sxg.1	-	2	591	c.47G>T	c.(46-48)GGC>GTC	p.G16V	KCNC2_uc009zry.2_Missense_Mutation_p.G16V|KCNC2_uc001sxe.2_Missense_Mutation_p.G16V|KCNC2_uc001sxf.2_Missense_Mutation_p.G16V|KCNC2_uc010stw.1_Missense_Mutation_p.G16V	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	16	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						GTGCCGGGTGCCCCCGACATT	0.602			NA											33	66					6.84511e-11	9.38275e-11	0.003271	1	0
E2F7	144455	broad.mit.edu	37	12	77421733	77421733	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:77421733C>A	uc001sym.3	-	11	2306	c.2070G>T	c.(2068-2070)AAG>AAT	p.K690N	E2F7_uc009zse.2_Missense_Mutation_p.K177N	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	690					cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3						CTTTTGAAGGCTTTTCAACAT	0.433			NA											40	20					1.07121e-22	1.88836e-22	0.006999	1	0
E2F7	144455	broad.mit.edu	37	12	77449844	77449844	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:77449844A>C	uc001sym.3	-	3	396	c.160T>G	c.(160-162)TTA>GTA	p.L54V	E2F7_uc001syn.2_Missense_Mutation_p.L54V	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	54					cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3						TGCTTCGATAAATCAATTGGT	0.358			NA											28	40					0	0	0.00632	0	0
NAV3	89795	broad.mit.edu	37	12	78522533	78522533	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:78522533G>T	uc001syp.2	+	18	4501	c.4328G>T	c.(4327-4329)TGG>TTG	p.W1443L	NAV3_uc001syo.2_Missense_Mutation_p.W1443L|NAV3_uc010sub.1_Missense_Mutation_p.W929L|NAV3_uc009zsf.2_Missense_Mutation_p.W274L	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1443	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GGCAAAGAGTGGTTGCGTTCT	0.502			NA								HNSCC(70;0.22)			39	59					1.62957e-23	2.91544e-23	0.00874	1	0
NAV3	89795	broad.mit.edu	37	12	78579401	78579401	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:78579401G>T	uc001syp.2	+	31	5886	c.5713G>T	c.(5713-5715)GGT>TGT	p.G1905C	NAV3_uc001syo.2_Missense_Mutation_p.G1883C|NAV3_uc010sub.1_Missense_Mutation_p.G1362C|NAV3_uc009zsf.2_Missense_Mutation_p.G714C	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1905						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AGATGATGCTGGTGATGCAAC	0.358			NA								HNSCC(70;0.22)			21	15					3.28513e-13	4.81418e-13	0.003954	1	0
SLC6A15	55117	broad.mit.edu	37	12	85260945	85260945	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:85260945A>T	uc001szv.2	-	10	2016	c.1523T>A	c.(1522-1524)ATT>AAT	p.I508N	SLC6A15_uc010sul.1_Missense_Mutation_p.I401N|SLC6A15_uc001szw.1_Missense_Mutation_p.I216N|uc001szx.2_5'Flank	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	508	Helical; Name=9; (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						TATCAGGCCAATACAAAATGC	0.318			NA											30	12					0	0	0.008361	0	0
SLC6A15	55117	broad.mit.edu	37	12	85285772	85285772	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:85285772C>T	uc001szv.2	-	2	621	c.128G>A	c.(127-129)GGC>GAC	p.G43D	SLC6A15_uc010sul.1_Intron|SLC6A15_uc001szy.2_Missense_Mutation_p.G43D	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	43	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						CTCTTCCTGGCCATCAACAAT	0.403			NA											54	102					0	0	0.00361	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85521787	85521787	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:85521787G>T	uc001tac.2	+	18	4296	c.4185G>T	c.(4183-4185)AGG>AGT	p.R1395S		NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1395	IQ 3.									ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		GAAAACAGAGGGAGAAGGCTG	0.299			NA											18	57					8.10497e-08	1.01718e-07	0.010504	1	0
SCYL2	55681	broad.mit.edu	37	12	100731216	100731216	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:100731216G>T	uc001thn.2	+	17	2127	c.2077G>T	c.(2077-2079)GCA>TCA	p.A693S	SCYL2_uc001thm.1_Missense_Mutation_p.A693S	NM_017988	NP_060458	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 protein	693	Potential.				endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			lung(3)|ovary(2)|skin(1)	6						ACAAGAGCAGGCACAGAAGCT	0.373			NA											58	29					7.92265e-33	1.48177e-32	0.00361	1	0
STAB2	55576	broad.mit.edu	37	12	104049297	104049297	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:104049297C>A	uc001tjw.2	+	15	1858	c.1672C>A	c.(1672-1674)CCA>ACA	p.P558T		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	558	Extracellular (Potential).|FAS1 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CATTTTTGTTCCAAATAATGA	0.438			NA											17	43					6.49762e-13	9.4072e-13	0.006122	1	0
MTERFD3	80298	broad.mit.edu	37	12	107371383	107371383	+	Silent	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:107371383T>C	uc001tme.1	-	2	2929	c.1110A>G	c.(1108-1110)AAA>AAG	p.K370K	MTERFD3_uc001tmf.1_Silent_p.K370K|MTERFD3_uc001tmg.1_Silent_p.K370K|MTERFD3_uc001tmh.1_Silent_p.K370K	NM_025198	NP_079474	Q49AM1	MTER3_HUMAN	transcription termination factor-like protein	370					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	transcription regulatory region DNA binding				0						ATGGCCTTACTTTTTTGGCCT	0.373			NA											11	72					0	0	0.001368	0	0
MTERFD3	80298	broad.mit.edu	37	12	107371394	107371394	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:107371394G>C	uc001tme.1	-	2	2918	c.1099C>G	c.(1099-1101)CAG>GAG	p.Q367E	MTERFD3_uc001tmf.1_Missense_Mutation_p.Q367E|MTERFD3_uc001tmg.1_Missense_Mutation_p.Q367E|MTERFD3_uc001tmh.1_Missense_Mutation_p.Q367E	NM_025198	NP_079474	Q49AM1	MTER3_HUMAN	transcription termination factor-like protein	367					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	transcription regulatory region DNA binding				0						TTTTTGGCCTGAATTTTGCCA	0.373			NA											11	76					0	0	0.001368	0	0
FICD	11153	broad.mit.edu	37	12	108910758	108910758	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:108910758C>A	uc001tmx.1	+	2	155	c.9C>A	c.(7-9)CTC>CTA	p.L3L		NM_007076	NP_009007	Q9BVA6	FICD_HUMAN	Huntingtin interacting protein E	3					negative regulation of Rho GTPase activity	integral to membrane	binding|protein adenylyltransferase activity				0						AGATGATGCTCATACCAATGG	0.592			NA											16	43					9.16793e-09	1.18993e-08	0.00499	1	0
ACACB	32	broad.mit.edu	37	12	109613743	109613743	+	Silent	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:109613743A>T	uc001tob.2	+	8	1343	c.1224A>T	c.(1222-1224)ACA>ACT	p.T408T	ACACB_uc001toc.2_Silent_p.T408T	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	408	Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	CAGGCCTGACAGTGGAGTGGA	0.502			NA											7	34					0	0	0.00308	0	0
CUX2	23316	broad.mit.edu	37	12	111746128	111746128	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:111746128C>T	uc001tsa.1	+	13	1302	c.1149C>T	c.(1147-1149)AGC>AGT	p.S383S		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	383						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GCACCTGCAGCCTCCCCCAGG	0.647			NA											48	89					0	0	0.00361	0	0
C12orf51	283450	broad.mit.edu	37	12	112702999	112702999	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:112702999T>G	uc009zwc.2	-	9	1321	c.1303A>C	c.(1303-1305)AAG>CAG	p.K435Q	C12orf51_uc010syk.1_Missense_Mutation_p.K258Q|C12orf51_uc001tts.2_Missense_Mutation_p.K258Q|C12orf51_uc001ttt.3_Missense_Mutation_p.K258Q	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GAAAGGAGCTTTTGAAAATCA	0.323			NA											24	41					0	0	0.004656	0	0
OAS3	4940	broad.mit.edu	37	12	113405356	113405356	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:113405356G>C	uc001tug.2	+	13	2910	c.2823G>C	c.(2821-2823)AAG>AAC	p.K941N		NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	941	OAS domain 3.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						GCCCTACCAAGCTGAAGAGCC	0.567			NA											15	18					0	0	0.007413	0	0
SDS	10993	broad.mit.edu	37	12	113837397	113837397	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:113837397G>T	uc001tvg.2	-	2	239	c.117C>A	c.(115-117)TCC>TCA	p.S39S	SDS_uc001tvh.1_Silent_p.S39S	NM_006843	NP_006834	P20132	SDHL_HUMAN	serine dehydratase	39					gluconeogenesis|L-serine catabolic process|pyruvate biosynthetic process	cytoplasm	L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|protein homodimerization activity|pyridoxal phosphate binding			pancreas(1)	1					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GGATCTTGAAGGAGCCGGAGG	0.627			NA											11	10					1.61879e-10	2.19183e-10	0.001368	1	0
TAOK3	51347	broad.mit.edu	37	12	118639195	118639195	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:118639195C>T	uc001twx.2	-	12	1188	c.893G>A	c.(892-894)CGT>CAT	p.R298H	TAOK3_uc001tww.2_Missense_Mutation_p.R128H|TAOK3_uc001twy.3_Missense_Mutation_p.R298H	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	298					MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ATCTAGCTCACGAACTGCATC	0.438			NA											16	78					0	0	0.004007	0	0
KNTC1	9735	broad.mit.edu	37	12	123087242	123087242	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:123087242C>T	uc001ucv.2	+	46	4943	c.4780C>T	c.(4780-4782)CAC>TAC	p.H1594Y	KNTC1_uc010taf.1_Intron	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1594					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		ACTGCCTTTTCACCTGATATT	0.363			NA											10	41					0	0	0.001368	0	0
DNAH10	196385	broad.mit.edu	37	12	124398903	124398903	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:124398903G>T	uc001uft.3	+	60	10051	c.10026G>T	c.(10024-10026)ATG>ATT	p.M3342I		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3342					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ATGAGCTGATGCACCGGCGCG	0.597			NA											29	38					5.60225e-13	8.16829e-13	0.009535	1	0
NCOR2	9612	broad.mit.edu	37	12	124827678	124827678	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:124827678G>A	uc010tba.1	-	33	4950	c.4833C>T	c.(4831-4833)CAC>CAT	p.H1611H	NCOR2_uc010tay.1_Silent_p.H1610H|NCOR2_uc010taz.1_Silent_p.H1594H|NCOR2_uc010tbb.1_Silent_p.H1603H|NCOR2_uc010tbc.1_Silent_p.H1593H|NCOR2_uc010tax.1_5'Flank	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	1611					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGTGTGGGTGGTGCTCGGGCA	0.657			NA											15	40					0	0	0.00499	0	0
NCOR2	9612	broad.mit.edu	37	12	124934381	124934381	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:124934381C>A	uc010tba.1	-	7	912	c.795G>T	c.(793-795)CAG>CAT	p.Q265H	NCOR2_uc010tay.1_Missense_Mutation_p.Q265H|NCOR2_uc010taz.1_Missense_Mutation_p.Q265H|NCOR2_uc010tbb.1_Missense_Mutation_p.Q265H|NCOR2_uc010tbc.1_Missense_Mutation_p.Q265H|NCOR2_uc001ugj.1_Missense_Mutation_p.Q265H|NCOR2_uc001ugk.1_Missense_Mutation_p.Q265H	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	265	Interaction with SIN3A/B (By similarity).				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TCTCATGATACTGCCGGGTGT	0.612			NA											12	43					1.5842e-08	2.03602e-08	0.001855	1	0
FZD10	11211	broad.mit.edu	37	12	130648391	130648391	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:130648391G>T	uc001uii.2	+	1	1360	c.904G>T	c.(904-906)GAG>TAG	p.E302*	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	302	Extracellular (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		TGTCATCCAGGAGGGACTGGA	0.647			NA											41	53					7.63091e-17	1.224e-16	0.007835	1	0
RIMBP2	23504	broad.mit.edu	37	12	130935883	130935883	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:130935883G>T	uc001uil.2	-	5	474	c.310C>A	c.(310-312)CAG>AAG	p.Q104K	RIMBP2_uc001uim.2_Missense_Mutation_p.Q12K	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	104						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GCGCTCTCCTGACCTGGCCAC	0.557			NA											15	33					7.93312e-07	9.56485e-07	0.00245	1	0
SFRS8	6433	broad.mit.edu	37	12	132249067	132249067	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:132249067A>T	uc001uja.1	+	12	1927	c.1787A>T	c.(1786-1788)AAT>ATT	p.N596I	SFRS8_uc010tbn.1_Missense_Mutation_p.N596I|SFRS8_uc001ujb.1_Missense_Mutation_p.N389I	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	596					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		CTGGAAAAAAATCGTGTTAAG	0.408			NA											6	76					0	0	0.001168	0	0
ANKLE2	23141	broad.mit.edu	37	12	133312078	133312078	+	Silent	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:133312078G>C	uc001ukx.2	-	9	1681	c.1614C>G	c.(1612-1614)CTC>CTG	p.L538L	ANKLE2_uc009zyw.1_5'Flank|ANKLE2_uc001uky.3_Silent_p.L476L	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	538						cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		GAGTTTTCCAGAGCTTGCGAA	0.517			NA											55	125					0	0	0.00361	0	0
GOLGA3	2802	broad.mit.edu	37	12	133373220	133373220	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:133373220C>A	uc001ukz.1	-	10	2564	c.2005G>T	c.(2005-2007)GAC>TAC	p.D669Y	GOLGA3_uc001ula.1_Missense_Mutation_p.D669Y|GOLGA3_uc001ulb.2_Missense_Mutation_p.D669Y	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	669	Gln-rich.|Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		CTCTGAAGGTCCTCCTCCACC	0.562			NA											132	292					3.19997e-73	6.21045e-73	0.00361	1	0
LATS2	26524	broad.mit.edu	37	13	21557801	21557801	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr13:21557801C>A	uc009zzs.2	-	5	2409	c.2044G>T	c.(2044-2046)GTG>TTG	p.V682L	LATS2_uc001unr.3_Missense_Mutation_p.V682L	NM_014572	NP_055387	Q9NRM7	LATS2_HUMAN	LATS, large tumor suppressor, homolog 2	682	Protein kinase.|ATP (By similarity).				cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(3)|ovary(2)|breast(1)|pancreas(1)	10		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		GCAAGGCACACTTCTCCAAAG	0.498			NA											26	27					3.01185e-09	3.94467e-09	0.003954	1	0
SACS	26278	broad.mit.edu	37	13	23909383	23909383	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr13:23909383C>A	uc001uon.2	-	10	9221	c.8632G>T	c.(8632-8634)GGG>TGG	p.G2878W	SACS_uc001uoo.2_Missense_Mutation_p.G2731W|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	2878					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AATGGCAGCCCAGTCTCCAAA	0.458			NA											7	31					5.18039e-06	6.06341e-06	0.00308	1	0
TNFRSF19	55504	broad.mit.edu	37	13	24190104	24190104	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr13:24190104G>T	uc001uov.1	+	4	343	c.279G>T	c.(277-279)CTG>CTT	p.L93L	TNFRSF19_uc001uot.2_Silent_p.L93L|TNFRSF19_uc010tcu.1_5'UTR|TNFRSF19_uc001uow.2_Silent_p.L93L	NM_018647	NP_061117	Q9NS68	TNR19_HUMAN	tumor necrosis factor receptor superfamily,	93	TNFR-Cys 2.|Extracellular (Potential).				apoptosis|induction of apoptosis|JNK cascade	integral to membrane|mitochondrion	tumor necrosis factor receptor activity			kidney(1)|skin(1)	2		all_cancers(29;3.4e-22)|all_epithelial(30;8.75e-19)|all_lung(29;5.09e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00193)|Epithelial(112;0.0137)|OV - Ovarian serous cystadenocarcinoma(117;0.0465)|GBM - Glioblastoma multiforme(144;0.184)|Lung(94;0.19)		AGCCCTGTCTGGACTGCGCAG	0.567			NA											33	19					8.73648e-17	1.39667e-16	0.004289	1	0
POMP	51371	broad.mit.edu	37	13	29252222	29252222	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr13:29252222A>G	uc001usf.2	+	6	490	c.409A>G	c.(409-411)AAA>GAA	p.K137E		NM_015932	NP_057016	Q9Y244	POMP_HUMAN	proteasome maturation protein	137					proteasome assembly	cytosol|endoplasmic reticulum|membrane|microsome|nucleus|proteasome complex					0		Lung SC(185;0.0367)		all cancers(112;0.141)|OV - Ovarian serous cystadenocarcinoma(117;0.216)		GGTGGAATATAAACTTGGTTT	0.338			NA											37	26					0	0	0.009718	0	0
BRCA2	675	broad.mit.edu	37	13	32936676	32936676	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr13:32936676C>T	uc001uub.1	+	17	8049	c.7822C>T	c.(7822-7824)CCA>TCA	p.P2608S		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2608					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding	p.P2608fs*40(1)		ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GTGTGACACTCCAGGTGTGGA	0.358	Esophageal Squamous(138;838 1285 7957 30353 30468 36915 49332)		NA	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	FanconAnemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			26	19					0	0	0.005443	0	0
SOHLH2	54937	broad.mit.edu	37	13	36748981	36748981	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr13:36748981G>T	uc001uvj.2	-	7	756	c.667C>A	c.(667-669)CAG>AAG	p.Q223K	SOHLH2_uc010tei.1_Missense_Mutation_p.Q300K	NM_017826	NP_060296	Q9NX45	SOLH2_HUMAN	spermatogenesis and oogenesis specific basic	223	Helix-loop-helix motif.				cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		GTACGCAGCTGCTCACAGCAA	0.383			NA											21	17					2.39556e-15	3.71441e-15	0.00278	1	0
ELF1	1997	broad.mit.edu	37	13	41515310	41515310	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr13:41515310G>A	uc001uxs.2	-	8	1376	c.1003C>T	c.(1003-1005)CCA>TCA	p.P335S	ELF1_uc010tfc.1_Missense_Mutation_p.P311S|ELF1_uc010acd.2_Missense_Mutation_p.P228S	NM_172373	NP_758961	P32519	ELF1_HUMAN	E74-like factor 1 (ets domain transcription	335					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Lung NSC(96;8.3e-05)|Prostate(109;0.0233)|Breast(139;0.0296)|Lung SC(185;0.0367)		all cancers(112;1.87e-08)|Epithelial(112;8.45e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000202)|GBM - Glioblastoma multiforme(144;0.00266)|BRCA - Breast invasive adenocarcinoma(63;0.072)		TTTACCCCTGGACTTGAAGAT	0.448			NA											11	83					0	0	0.00245	0	0
SERPINE3	647174	broad.mit.edu	37	13	51915467	51915467	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr13:51915467G>A	uc001vfh.2	+	1	300	c.240G>A	c.(238-240)CTG>CTA	p.L80L	SERPINE3_uc010tgp.1_Silent_p.L80L	NM_001101320	NP_001094790	A8MV23	SERP3_HUMAN	nexin-related serine protease inhibitor	80					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)	2						CAGATGCCCTGGGGTACACTG	0.408			NA											3	2					0	0	0.004672	0	0
ATP7B	540	broad.mit.edu	37	13	52513223	52513223	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr13:52513223C>A	uc001vfw.2	-	17	3820	c.3663G>T	c.(3661-3663)GGG>GGT	p.G1221G	ATP7B_uc010adv.2_Silent_p.G791G|ATP7B_uc001vfx.2_Silent_p.G1014G|ATP7B_uc001vfy.2_Silent_p.G1110G|ATP7B_uc010tgt.1_Silent_p.G1156G|ATP7B_uc010tgu.1_Silent_p.G1173G|ATP7B_uc010tgv.1_Silent_p.G1143G|ATP7B_uc001vfv.2_Silent_p.G493G|ATP7B_uc010tgs.1_Silent_p.G432G	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	1221	Cytoplasmic (Potential).		G -> E (in WD).		ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		TCCGGTTGTCCCCCGTGATCA	0.532			NA							Wilson_disease				36	24					3.78316e-11	5.2254e-11	0.00623	1	0
KLHL1	57626	broad.mit.edu	37	13	70293684	70293684	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr13:70293684C>A	uc001vip.2	-	9	2626	c.1832G>T	c.(1831-1833)AGT>ATT	p.S611I	KLHL1_uc010thm.1_Missense_Mutation_p.S550I	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	611	Kelch 4.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CAAACAGGAACTTCCATCACG	0.388			NA											15	9					1.3612e-06	1.62893e-06	0.003163	1	0
KLF5	688	broad.mit.edu	37	13	73636638	73636638	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr13:73636638C>T	uc001vje.2	+	2	1225	c.901C>T	c.(901-903)CCC>TCC	p.P301S	KLF5_uc001vjd.2_Missense_Mutation_p.P210S	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	301			P -> S (in a colorectal cancer sample; somatic mutation).		transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding	p.P301S(1)		large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		CACTTACTTTCCCCCGTCACC	0.512			NA											46	25					0	0	0.002522	0	0
MYCBP2	23077	broad.mit.edu	37	13	77642954	77642954	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr13:77642954T>C	uc001vkf.2	-	71	11894	c.11803A>G	c.(11803-11805)ATT>GTT	p.I3935V	MYCBP2_uc010aev.2_Missense_Mutation_p.I3339V|MYCBP2_uc001vke.2_Missense_Mutation_p.I552V	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3935					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GCTTGGACAATATGAGCACAC	0.363			NA											17	49					0	0	0.006122	0	0
MYCBP2	23077	broad.mit.edu	37	13	77671869	77671869	+	Silent	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr13:77671869G>C	uc001vkf.2	-	57	9397	c.9306C>G	c.(9304-9306)ACC>ACG	p.T3102T	MYCBP2_uc010aev.2_Silent_p.T2506T|MYCBP2_uc001vkg.1_Silent_p.T625T|MYCBP2_uc010aew.2_Silent_p.T488T	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3102					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TTTCAAAAGTGGTCTCGGTTT	0.388			NA											15	59					0	0	0.003163	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455420	84455420	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr13:84455420G>C	uc001vlk.2	-	1	1109	c.223C>G	c.(223-225)CCT>GCT	p.P75A		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	75	LRR 1.|Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		AACTCATTAGGGAAAAGTCGA	0.463			NA											32	27					0	0	0.002096	0	0
COL4A1	1282	broad.mit.edu	37	13	110859048	110859048	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr13:110859048G>A	uc001vqw.3	-	15	944	c.822C>T	c.(820-822)GTC>GTT	p.V274V	COL4A1_uc010agl.2_Silent_p.V274V	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	274	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CTTTCTCTCCGACCCCTGGCA	0.343			NA											26	60					0	0	0.002096	0	0
POTEG	404785	broad.mit.edu	37	14	19553759	19553759	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:19553759A>T	uc001vuz.1	+	1	395	c.343A>T	c.(343-345)AGC>TGC	p.S115C	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	115										ovary(1)	1						GAGCGGCAAGAGCAAAGTGGG	0.597			NA											28	406					0	0	0.002445	0	0
OR4K2	390431	broad.mit.edu	37	14	20345054	20345054	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:20345054T>A	uc001vwh.1	+	1	628	c.628T>A	c.(628-630)TGT>AGT	p.C210S		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGCGTTGTCCTGTTTTATTGT	0.398			NA											16	109					0	0	0.006122	0	0
OR4K17	390436	broad.mit.edu	37	14	20586176	20586177	+	Missense_Mutation	DNP	TG	TG	GT			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:20586176_20586177TG>GT	uc001vwo.1	+	1	611_612	c.611_612TG>GT	c.(610-612)GTG>GGT	p.V204G		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GGTCCCAATGTGGTAGACAGCA	0.431			NA											32	62					0	0	0.004672	0	0
OR11G2	390439	broad.mit.edu	37	14	20666392	20666392	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:20666392C>A	uc010tlb.1	+	1	898	c.898C>A	c.(898-900)CCA>ACA	p.P300T		NM_001005503	NP_001005503	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G,	300	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GTATGGGAGcccaccatctaa	0.289			NA											34	62					1.45844e-13	2.17034e-13	0.002836	1	0
RNASE2	6036	broad.mit.edu	37	14	21423997	21423997	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:21423997G>T	uc010aif.2	+	2	136	c.67G>T	c.(67-69)GGC>TGC	p.G23C	RNASE2_uc001vyl.1_Missense_Mutation_p.G23C	NM_002934	NP_002925	P10153	RNAS2_HUMAN	ribonuclease, RNase A family, 2 (liver,	23					chemotaxis|RNA catabolic process	extracellular region|lysosome	nucleic acid binding|pancreatic ribonuclease activity			ovary(1)	1	all_cancers(95;0.00381)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)		GGCTGTGGAGGGCTCACTCCA	0.463			NA											17	51					2.5808e-16	4.08957e-16	0.006122	1	0
NDRG2	57447	broad.mit.edu	37	14	21490241	21490242	+	Missense_Mutation	DNP	TC	TC	AA			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:21490241_21490242TC>AA	uc001vyy.2	-	6	473_474	c.323_324GA>TT	c.(322-324)GGA>GTT	p.G108V	NDRG2_uc010tll.1_Missense_Mutation_p.G104V|NDRG2_uc001vyt.2_Missense_Mutation_p.G21V|NDRG2_uc001vyu.2_Missense_Mutation_p.G94V|NDRG2_uc001vyv.2_Missense_Mutation_p.G94V|NDRG2_uc001vyw.2_Missense_Mutation_p.G94V|NDRG2_uc001vzb.2_Missense_Mutation_p.G48V|NDRG2_uc001vyx.2_Missense_Mutation_p.G108V|NDRG2_uc001vza.2_Missense_Mutation_p.G94V|NDRG2_uc001vyz.2_Missense_Mutation_p.G94V|NDRG2_uc001vzc.2_Missense_Mutation_p.G94V|NDRG2_uc001vze.2_Missense_Mutation_p.G108V|NDRG2_uc001vzd.2_Missense_Mutation_p.G108V|NDRG2_uc001vzg.2_Missense_Mutation_p.G94V|NDRG2_uc001vzf.2_Missense_Mutation_p.G94V|NDRG2_uc010aig.2_Missense_Mutation_p.G108V	NM_201540	NP_963834	Q9UN36	NDRG2_HUMAN	N-myc downstream-regulated gene 2 isoform a	108					cell differentiation|nervous system development	centrosome|cytosol|Golgi apparatus|nucleus|perinuclear region of cytoplasm				ovary(1)|breast(1)	2	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		ACACAGGGGCTCCCTCTTCCAT	0.52			NA											12	51					0	0	0.004672	0	0
MYH6	4624	broad.mit.edu	37	14	23855649	23855649	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:23855649C>T	uc001wjv.2	-	33	4901	c.4834G>A	c.(4834-4836)GAG>AAG	p.E1612K		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	1612	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CTCAGGACCTCGTTGCGGCTG	0.607			NA											83	83					0	0	0.00361	0	0
JPH4	84502	broad.mit.edu	37	14	24041027	24041027	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:24041027G>T	uc001wkq.2	-	5	2172	c.1254C>A	c.(1252-1254)CCC>CCA	p.P418P	JPH4_uc010tnr.1_Silent_p.P83P|JPH4_uc001wkr.2_Silent_p.P418P	NM_032452	NP_115828	Q96JJ6	JPH4_HUMAN	junctophilin 4	418	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				ovary(1)|pancreas(1)	2	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		CCTCTAGCATGGGCTGCAGGT	0.632			NA											61	58					1.53582e-20	2.64279e-20	0.00361	1	0
PSME2	5721	broad.mit.edu	37	14	24614455	24614455	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:24614455C>A	uc001wmj.2	-	5	324	c.259G>T	c.(259-261)GAA>TAA	p.E87*	PSME2_uc001wmk.2_Nonsense_Mutation_p.E10*|RNF31_uc001wml.1_5'Flank|RNF31_uc001wmm.1_5'Flank|RNF31_uc001wmn.1_5'Flank|RNF31_uc010alg.1_5'Flank	NM_002818	NP_002809	Q9UL46	PSME2_HUMAN	proteasome activator subunit 2	87					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome activator complex					0				GBM - Glioblastoma multiforme(265;0.00839)		CTCTTACCTTCTTTCTTCTCC	0.458			NA											15	74					1.5739e-10	2.13908e-10	0.004007	1	0
CIDEB	27141	broad.mit.edu	37	14	24775613	24775613	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:24775613C>T	uc001won.2	-	3	427	c.303G>A	c.(301-303)GTG>GTA	p.V101V	CIDEB_uc001woo.2_Silent_p.V101V|CIDEB_uc001wop.2_Silent_p.V101V|LTB4R2_uc001woq.1_5'Flank	NM_014430	NP_055245	Q9UHD4	CIDEB_HUMAN	cell death-inducing DFFA-like effector b	101	CIDE-N.				apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis	cytosol					0				GBM - Glioblastoma multiforme(265;0.0181)		CAGACTGCAACACCATCAGGC	0.552			NA											17	110					0	0	0.008871	0	0
KHNYN	23351	broad.mit.edu	37	14	24901093	24901093	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:24901093G>C	uc001wph.3	+	3	828	c.626G>C	c.(625-627)TGG>TCG	p.W209S	KHNYN_uc010tpc.1_Missense_Mutation_p.W250S|KHNYN_uc010alw.2_Missense_Mutation_p.W209S|CBLN3_uc001wpg.3_5'Flank	NM_015299	NP_056114	O15037	KHNYN_HUMAN	hypothetical protein LOC23351	209										ovary(2)|liver(1)	3						CTGGCTTCTTGGGAGGGGCGG	0.642			NA									OREG0022627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	79					0	0	0.005443	0	0
CTSG	1511	broad.mit.edu	37	14	25042850	25042851	+	Missense_Mutation	DNP	GG	GG	CT			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:25042850_25042851GG>CT	uc001wpq.2	-	5	797_798	c.760_761CC>AG	c.(760-762)CCC>AGC	p.P254S		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	254					immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		CAGTCACAGGGGGGTCTCCATC	0.495			NA											124	122					0	0	0.004672	0	0
PRKD1	5587	broad.mit.edu	37	14	30068940	30068940	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:30068940A>T	uc001wqh.2	-	14	2170	c.1989T>A	c.(1987-1989)CAT>CAA	p.H663Q		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	663	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		GCATGTCTCCATGGAGTTTTT	0.378			NA											13	113					0	0	0.00245	0	0
AKAP6	9472	broad.mit.edu	37	14	33068651	33068651	+	Silent	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:33068651C>G	uc001wrq.2	+	6	2675	c.2505C>G	c.(2503-2505)CTC>CTG	p.L835L	AKAP6_uc010aml.2_Silent_p.L832L	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	835	Spectrin 1.				protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		ATTGTGCTCTCAAGGAAGCTG	0.393	Melanoma(49;821 1200 7288 13647 42351)		NA											29	84					0	0	0.002445	0	0
SRP54	6729	broad.mit.edu	37	14	35478009	35478009	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:35478009A>T	uc001wso.2	+	7	808	c.457A>T	c.(457-459)ACC>TCC	p.T153S	SRP54_uc010tpp.1_Missense_Mutation_p.T104S|SRP54_uc010tpq.1_Missense_Mutation_p.T89S	NM_003136	NP_003127	P61011	SRP54_HUMAN	signal recognition particle 54kDa isoform 1	153	G-domain.				GTP catabolic process|response to drug|SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|SRP-dependent cotranslational protein targeting to membrane, translocation	cytosol|nuclear speck|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|drug binding|endoplasmic reticulum signal peptide binding|GDP binding|GTP binding|nucleoside-triphosphatase activity|ribonucleoprotein binding			ovary(1)	1	Breast(36;0.0545)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;2.48e-05)|Lung(238;3.13e-05)|Epithelial(34;0.0314)|all cancers(34;0.0797)|BRCA - Breast invasive adenocarcinoma(188;0.243)	GBM - Glioblastoma multiforme(112;0.0396)		ACAGAATGCTACCAAAGCAAG	0.279			NA											46	28					0	0	0.00361	0	0
PPP2R3C	55012	broad.mit.edu	37	14	35585916	35585916	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:35585916T>G	uc001wss.2	-	2	440	c.86A>C	c.(85-87)GAT>GCT	p.D29A	PPP2R3C_uc001wst.2_Intron|PPP2R3C_uc010tpr.1_Intron|PPP2R3C_uc001wsu.2_Intron|PPP2R3C_uc010amn.1_Missense_Mutation_p.D29A|PPP2R3C_uc001wsw.2_Missense_Mutation_p.D29A|PPP2R3C_uc001wsx.1_Missense_Mutation_p.D29A	NM_017917	NP_060387	Q969Q6	P2R3C_HUMAN	serine/threonine-protein phosphatase 2A	29						centrosome|nucleus	calcium ion binding			ovary(1)	1	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;8.62e-06)|LUAD - Lung adenocarcinoma(48;1.42e-05)|Epithelial(34;0.0177)|all cancers(34;0.0491)	GBM - Glioblastoma multiforme(112;0.0803)		CATTTCTTCATCTTTTAATTC	0.303			NA											6	41					0	0	0.001984	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36159114	36159114	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:36159114C>A	uc001wti.2	-	17	2753	c.2362G>T	c.(2362-2364)GAG>TAG	p.E788*	RALGAPA1_uc001wtj.2_Nonsense_Mutation_p.E788*|RALGAPA1_uc010tpv.1_Nonsense_Mutation_p.E788*|RALGAPA1_uc010tpw.1_Nonsense_Mutation_p.E835*|RALGAPA1_uc001wtk.1_Nonsense_Mutation_p.E686*	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	788					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						GGCTGCTCCTCATTCAAAGCA	0.428			NA											177	43					4.28478e-88	8.33827e-88	0.00361	1	0
CLEC14A	161198	broad.mit.edu	37	14	38724207	38724207	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:38724207T>A	uc001wum.1	-	1	1368	c.1021A>T	c.(1021-1023)ACA>TCA	p.T341S		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	341	Extracellular (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		GGAATAGATGTTACTGAATTG	0.537			NA											30	215					0	0	0.002445	0	0
PNN	5411	broad.mit.edu	37	14	39644496	39644496	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:39644496G>T	uc001wuw.3	+	1	110	c.13G>T	c.(13-15)GTG>TTG	p.V5L		NM_002687	NP_002678	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	5	Potential.|Necessary for interaction with RNPS1.|Necessary for mediating alternative 5' splicing.|Necessary for interactions with KRT8, KRT18 and KRT19.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			ovary(1)	1	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		GGCGGTCGCCGTGAGAACTTT	0.607			NA											51	14					6.03219e-31	1.12674e-30	0.00361	1	0
MDGA2	161357	broad.mit.edu	37	14	47530713	47530713	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:47530713G>T	uc001wwj.3	-	7	1253	c.1057C>A	c.(1057-1059)CGT>AGT	p.R353S	MDGA2_uc001wwi.3_Missense_Mutation_p.R124S|MDGA2_uc010ani.2_5'UTR	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	353	Ig-like 4.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						TTCACCTCACGGCCAATCTGG	0.383			NA											12	36					0.00010058	0.000112257	0.001368	1	0
PYGL	5836	broad.mit.edu	37	14	51383714	51383714	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:51383714C>A	uc001wyu.2	-	8	1092	c.965G>T	c.(964-966)GGT>GTT	p.G322V	PYGL_uc010tqq.1_Missense_Mutation_p.G288V|PYGL_uc001wyv.2_5'UTR|PYGL_uc010anz.1_Missense_Mutation_p.G125V	NM_002863	NP_002854	P06737	PYGL_HUMAN	liver glycogen phosphorylase isoform 1	322					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	AGTTCCTGCACCACGGGTGGA	0.498			NA											16	67					3.32936e-07	4.06514e-07	0.006122	1	0
TXNDC16	57544	broad.mit.edu	37	14	52907281	52907281	+	Splice_Site	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:52907281C>A	uc001wzs.2	-	19	2452	c.2003_splice	c.e19+1	p.L668_splice	TXNDC16_uc010tqu.1_Splice_Site_p.L663_splice|TXNDC16_uc010aoe.2_Splice_Site	NM_020784	NP_065835	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16 isoform 1						cell redox homeostasis	extracellular region					0	Breast(41;0.0716)					CACATACTTACAGATTTAACC	0.294			NA											5	22					1.23904e-05	1.4328e-05	0.000602	1	0
C14orf101	54916	broad.mit.edu	37	14	57083899	57083900	+	Splice_Site	DNP	AG	AG	TA			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	AG	AG	-	-	AG	AG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:57083899_57083900AG>TA	uc001xcm.2	+	9	1064	c.942_splice	c.e9-1	p.K314_splice	C14orf101_uc001xcj.2_Splice_Site|C14orf101_uc001xcl.1_Splice_Site|C14orf101_uc001xcn.2_Intron|C14orf101_uc010trf.1_Splice_Site|C14orf101_uc001xco.2_Splice_Site	NM_017799	NP_060269	Q9NX78	CN101_HUMAN	hypothetical protein LOC54916							integral to membrane				breast(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(311;0.226)		TATTTTTTGTAGGGACAGACAG	0.262			NA											8	39					0	0	0.004672	0	0
PRKCH	5583	broad.mit.edu	37	14	61920037	61920037	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:61920037T>G	uc001xfn.2	+	7	1231	c.926T>G	c.(925-927)ATG>AGG	p.M309R	PRKCH_uc010tsa.1_Missense_Mutation_p.M148R	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	309					intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		CTGGCAGGGATGGGTCTCCAA	0.468	Melanoma(135;863 1779 8064 14443 26348)		NA											4	33					0	0	0.009096	0	0
KCNH5	27133	broad.mit.edu	37	14	63417143	63417143	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:63417143C>T	uc001xfx.2	-	7	1128	c.1077G>A	c.(1075-1077)GTG>GTA	p.V359V	KCNH5_uc001xfy.2_Silent_p.V359V|KCNH5_uc001xfz.1_Silent_p.V301V|KCNH5_uc001xga.2_Silent_p.V301V	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	359	Helical; Name=Segment S5; (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GCCAGTGGGCCACCAGTCCAA	0.527			NA											16	47					0	0	0.006122	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65198849	65198849	+	Missense_Mutation	SNP	C	C	T	rs142732386	byFrequency	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:65198849C>T	uc001xho.1	+	10	1431	c.1162C>T	c.(1162-1164)CAC>TAC	p.H388Y	PLEKHG3_uc001xhn.1_Missense_Mutation_p.H332Y|PLEKHG3_uc001xhp.2_Missense_Mutation_p.H388Y|PLEKHG3_uc010aqh.1_5'UTR	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	388	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		CTGGACTCACCACATCAAGAG	0.547			NA											11	28					0	0	0.000978	0	0
FAM71D	161142	broad.mit.edu	37	14	67664975	67664975	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:67664975T>G	uc001xja.1	+	3	351	c.97T>G	c.(97-99)TTG>GTG	p.L33V	FAM71D_uc010tsv.1_RNA|FAM71D_uc001xiz.2_RNA|FAM71D_uc010aqn.1_RNA	NM_173526	NP_775797	Q8N9W8	FA71D_HUMAN	hypothetical protein LOC161142	33										ovary(1)	1		all_hematologic(31;0.0116)		all cancers(60;0.00107)|BRCA - Breast invasive adenocarcinoma(234;0.00993)|OV - Ovarian serous cystadenocarcinoma(108;0.012)		TCAAAATATGTTGGATGGAGG	0.433			NA											16	62					0	0	0.00499	0	0
SLC8A3	6547	broad.mit.edu	37	14	70515701	70515701	+	Nonsense_Mutation	SNP	G	G	T	rs149109491	byFrequency	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:70515701G>T	uc001xly.2	-	7	2944	c.2190C>A	c.(2188-2190)TAC>TAA	p.Y730*	SLC8A3_uc001xlu.2_Nonsense_Mutation_p.Y87*|SLC8A3_uc001xlv.2_Nonsense_Mutation_p.Y101*|SLC8A3_uc001xlw.2_Nonsense_Mutation_p.Y727*|SLC8A3_uc001xlx.2_Nonsense_Mutation_p.Y728*|SLC8A3_uc001xlz.2_Nonsense_Mutation_p.Y724*|SLC8A3_uc010ara.2_RNA|SLC8A3_uc001xma.2_Nonsense_Mutation_p.Y87*	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	730	Helical; (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		AGTGCATGACGTAGTCAAAGC	0.572			NA											12	32					3.07112e-06	3.6122e-06	0.000978	1	0
SIPA1L1	26037	broad.mit.edu	37	14	72190593	72190593	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:72190593G>A	uc001xms.2	+	16	4849	c.4501G>A	c.(4501-4503)GAC>AAC	p.D1501N	SIPA1L1_uc001xmt.2_Missense_Mutation_p.D1480N|SIPA1L1_uc001xmu.2_Missense_Mutation_p.D1480N|SIPA1L1_uc001xmv.2_Missense_Mutation_p.D1501N|SIPA1L1_uc010ttm.1_Missense_Mutation_p.D955N|SIPA1L1_uc001xmw.2_Missense_Mutation_p.D266N	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1501					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GGGATTTATGGACACGAGAAA	0.448			NA											8	53					0	0	0.00308	0	0
LTBP2	4053	broad.mit.edu	37	14	75019645	75019645	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:75019645A>C	uc001xqa.2	-	5	1529	c.1142T>G	c.(1141-1143)CTG>CGG	p.L381R		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	381					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CTGGCTGTACAGGGTGGTGGT	0.592			NA											8	15					0	0	0.00308	0	0
NRXN3	9369	broad.mit.edu	37	14	79933641	79933641	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:79933641C>A	uc001xun.2	+	13	2712	c.2221C>A	c.(2221-2223)CGG>AGG	p.R741R	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Silent_p.R109R|NRXN3_uc010asw.2_Silent_p.R109R|NRXN3_uc001xur.3_Silent_p.R109R	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1114	Extracellular (Potential).|Laminin G-like 6.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GCCCAGCACGCGGTCTGACCG	0.577			NA											22	31					1.10923e-09	1.4661e-09	0.00278	1	0
TSHR	7253	broad.mit.edu	37	14	81610378	81610378	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:81610378C>A	uc001xvd.1	+	10	2132	c.1976C>A	c.(1975-1977)TCC>TAC	p.S659Y		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	659	Extracellular (Potential).		Missing (in hyperthyroidism; associated with hyperfunctioning thyroid adenomas).		cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	GTTAGCAACTCCAAAATCTTG	0.448			NA	Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						45	70					1.35964e-18	2.26921e-18	0.00361	1	0
KIAA1409	57578	broad.mit.edu	37	14	94044226	94044226	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:94044226C>A	uc001ybv.1	+	15	1802	c.1719C>A	c.(1717-1719)CAC>CAA	p.H573Q	KIAA1409_uc001ybs.1_Missense_Mutation_p.H573Q	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	750						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GAGTTCAGCACAATATGCTTA	0.453			NA											23	104					3.5997e-14	5.43536e-14	0.002299	1	0
FAM181A	90050	broad.mit.edu	37	14	94395378	94395378	+	Silent	SNP	C	C	A	rs34468063		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:94395378C>A	uc001ybz.1	+	3	1240	c.933C>A	c.(931-933)CCC>CCA	p.P311P	C14orf86_uc001yby.2_5'Flank|FAM181A_uc010aus.1_Silent_p.P249P|FAM181A_uc001yca.1_Silent_p.P249P	NM_138344	NP_612353	Q8N9Y4	F181A_HUMAN	hypothetical protein LOC90050	311											0						CAGCCTTTCCCGGGGAGCTGG	0.672			NA											12	23					5.50884e-06	6.41659e-06	0.001368	1	0
SERPINA9	327657	broad.mit.edu	37	14	94931119	94931119	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:94931119C>T	uc001ydf.2	-	4	1190	c.1029G>A	c.(1027-1029)ATG>ATA	p.M343I	SERPINA9_uc001yde.2_Missense_Mutation_p.M243I|SERPINA9_uc010avc.2_Missense_Mutation_p.M194I|SERPINA9_uc001ydg.2_Missense_Mutation_p.M307I|SERPINA9_uc001ydh.1_Missense_Mutation_p.M343I|SERPINA9_uc001ydi.1_Missense_Mutation_p.M307I	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	325					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		TTTGGATGCCCATCTTCGGGA	0.413			NA											11	36					0	0	0.001368	0	0
SERPINA12	145264	broad.mit.edu	37	14	94953696	94953696	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:94953696C>G	uc001ydj.2	-	6	1985	c.1189G>C	c.(1189-1191)GAG>CAG	p.E397Q		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	397					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		GGTATTTTCTCGCTGTAAATC	0.522			NA											9	60					0	0	0.000978	0	0
SERPINA12	145264	broad.mit.edu	37	14	94964309	94964309	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:94964309C>A	uc001ydj.2	-	3	1222	c.426G>T	c.(424-426)CAG>CAT	p.Q142H		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	142					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity	p.Q142R(1)		central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		GCTGCAGCCTCTGGTCAATGA	0.468			NA											31	45					1.26612e-14	1.94021e-14	0.003271	1	0
SERPINA4	5267	broad.mit.edu	37	14	95029947	95029947	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:95029947G>A	uc001ydk.2	+	2	194	c.128G>A	c.(127-129)GGT>GAT	p.G43D	SERPINA4_uc010avd.2_Missense_Mutation_p.G80D|SERPINA4_uc001ydl.2_Missense_Mutation_p.G43D	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	43					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		CTGGAGACAGGTGAGGGCTCC	0.562			NA											14	33					0	0	0.00245	0	0
TCL1B	9623	broad.mit.edu	37	14	96152899	96152899	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:96152899G>T	uc001yez.2	+	1	137	c.95G>T	c.(94-96)TGG>TTG	p.W32L	TCL1B_uc001yew.2_Intron|TCL1B_uc001yex.2_Intron|TCL1B_uc010avj.2_Intron|TCL1B_uc001yfa.2_Missense_Mutation_p.W32L	NM_004918	NP_004909	O95988	TCL1B_HUMAN	T-cell leukemia/lymphoma 1B	32										ovary(1)	1		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		GGGAGAACCTGGGTGACTGTG	0.647			NA											18	17					1.67942e-08	2.14882e-08	0.006122	1	0
OR4M2	390538	broad.mit.edu	37	15	22368785	22368785	+	Silent	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:22368785T>C	uc010tzu.1	+	1	210	c.210T>C	c.(208-210)GAT>GAC	p.D70D	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CCTTCCTTGATATTTGGTACT	0.418			NA											35	164					0	0	0.004878	0	0
C15orf2	23742	broad.mit.edu	37	15	24921181	24921181	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:24921181G>T	uc001ywo.2	+	1	641	c.167G>T	c.(166-168)CGT>CTT	p.R56L		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	56					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CGGAACGCCCGTCGCAGGCCT	0.751			NA											10	9					1.11149e-13	1.65918e-13	0.008291	1	0
RYR3	6263	broad.mit.edu	37	15	33878306	33878306	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:33878306C>A	uc001zhi.2	+	16	1847	c.1777C>A	c.(1777-1779)CGG>AGG	p.R593R	RYR3_uc010bar.2_Silent_p.R593R	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	593	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TAAGCACGGGCGGAATCACAA	0.473			NA											14	11					6.31663e-08	7.96204e-08	0.003163	1	0
RYR3	6263	broad.mit.edu	37	15	34078113	34078113	+	Silent	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:34078113G>C	uc001zhi.2	+	66	9589	c.9519G>C	c.(9517-9519)CTG>CTC	p.L3173L	RYR3_uc010bar.2_Silent_p.L3173L	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3173					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GTCTCATCCTGGGCAACATTC	0.577			NA											25	94					0	0	0.003954	0	0
C15orf23	90417	broad.mit.edu	37	15	40675101	40675101	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:40675101G>A	uc001zll.2	+	1	180	c.65G>A	c.(64-66)TGC>TAC	p.C22Y	C15orf23_uc010ucp.1_Missense_Mutation_p.C22Y|C15orf23_uc001zlo.2_Missense_Mutation_p.C22Y|C15orf23_uc001zlm.2_RNA|C15orf23_uc001zln.2_RNA	NM_033286	NP_150628	Q9Y448	T4AF1_HUMAN	TRAF4 associated factor 1 isoform a	22						nucleus	protein binding			ovary(1)|skin(1)	2		all_cancers(109;2.34e-14)|all_epithelial(112;9.21e-12)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.39e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0798)		TCTACAGAGTGCGATTCCCAC	0.572			NA											10	28					0	0	0.006214	0	0
CASC5	57082	broad.mit.edu	37	15	40917839	40917839	+	Splice_Site	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:40917839G>T	uc010bbs.1	+	11	5615	c.5454_splice	c.e11+1	p.E1818_splice	CASC5_uc001zme.2_Missense_Mutation_p.V1793L|CASC5_uc010bbt.1_Splice_Site_p.E1792_splice	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1						acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		AGATCGGGAGGTGAGCTCTGT	0.338			NA											17	17					2.23348e-06	2.64207e-06	0.004007	1	0
FAM82A2	55177	broad.mit.edu	37	15	41046915	41046915	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:41046915C>G	uc001zmo.1	-	2	211	c.67G>C	c.(67-69)GGC>CGC	p.G23R	FAM82A2_uc001zmp.1_Missense_Mutation_p.G23R|FAM82A2_uc001zmq.1_Missense_Mutation_p.G23R	NM_018145	NP_060615	Q96TC7	RMD3_HUMAN	family with sequence similarity 82, member A2	23	Helical; (Potential).				apoptosis|cell differentiation	integral to membrane|microtubule|mitochondrial membrane|nucleus|spindle pole	protein binding				0						AATCCAAGGCCGGCGGCGGTA	0.647			NA											11	13					0	0	0.008291	0	0
VPS18	57617	broad.mit.edu	37	15	41192839	41192839	+	Missense_Mutation	SNP	G	G	T	rs34865655	byFrequency	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:41192839G>T	uc001zne.2	+	4	2162	c.1823G>T	c.(1822-1824)CGC>CTC	p.R608L		NM_020857	NP_065908	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18	608					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			ovary(2)|large_intestine(1)	3		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CACATCCCCCGCCAGCTTGTA	0.632			NA											32	47					1.55811e-20	2.67794e-20	0.008361	1	0
PDIA3	2923	broad.mit.edu	37	15	44058156	44058156	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:44058156A>T	uc001zsu.2	+	7	939	c.791A>T	c.(790-792)TAC>TTC	p.Y264F	PDIA3_uc010bdp.2_Missense_Mutation_p.Y244F|PDIA3_uc010ued.1_Missense_Mutation_p.Y38F	NM_005313	NP_005304	P30101	PDIA3_HUMAN	protein disulfide-isomerase A3 precursor	264					cell redox homeostasis|glycerol ether metabolic process|post-translational protein modification|protein folding|protein import into nucleus|protein N-linked glycosylation via asparagine|protein retention in ER lumen|signal transduction	endoplasmic reticulum lumen|melanosome	cysteine-type endopeptidase activity|electron carrier activity|phospholipase C activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)|skin(1)	2		all_cancers(109;2.61e-15)|all_epithelial(112;1.12e-12)|Lung NSC(122;2.17e-08)|all_lung(180;2.45e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.48e-07)		CTTATTGCTTACTATGATGTG	0.358			NA											29	15					0	0	0.007291	0	0
LMAN1L	79748	broad.mit.edu	37	15	75115996	75115996	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:75115996C>A	uc002ayt.1	+	12	1298	c.1296C>A	c.(1294-1296)CTC>CTA	p.L432L	LMAN1L_uc010bke.1_Silent_p.L420L|CPLX3_uc002ayu.1_5'Flank	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like precursor	432	Lumenal (Potential).					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0						TCCTGGGCCTCCTGCAGGAGG	0.617			NA											20	23					1.50039e-11	2.10463e-11	0.001882	1	0
CSPG4	1464	broad.mit.edu	37	15	75981642	75981642	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:75981642C>T	uc002baw.2	-	3	1857	c.1764G>A	c.(1762-1764)GAG>GAA	p.E588E		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	588	Extracellular (Potential).|CSPG 2.|Globular or compact configuration stabilized by disulfide bonds.|Interaction with COL6A2 (By similarity).|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						AGGTGAGGCCCTCACAGGCAG	0.652			NA											3	23					0	0	0.004672	0	0
WDR61	80349	broad.mit.edu	37	15	78577629	78577629	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:78577629G>A	uc002bdn.2	-	10	878	c.802C>T	c.(802-804)CAC>TAC	p.H268Y	WDR61_uc002bdo.2_Missense_Mutation_p.H268Y	NM_025234	NP_079510	Q9GZS3	WDR61_HUMAN	WD repeat domain 61	268	WD 6.						protein binding			ovary(1)|skin(1)	2						AAGAAGGTGTGAACACAAGTC	0.373			NA											13	31					0	0	0.006122	0	0
IL16	3603	broad.mit.edu	37	15	81517848	81517848	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:81517848C>A	uc002bgh.3	+	2	484	c.108C>A	c.(106-108)AGC>AGA	p.S36R	IL16_uc002bgc.2_RNA|IL16_uc010blq.1_Missense_Mutation_p.S36R|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.S78R|IL16_uc002bgg.2_Missense_Mutation_p.S36R	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	36					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						ATGGCTCTAGCCCTGATGAGA	0.517			NA											18	19					5.35267e-07	6.49709e-07	0.007413	1	0
MEX3B	84206	broad.mit.edu	37	15	82336839	82336839	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:82336839C>T	uc002bgq.1	-	2	687	c.372G>A	c.(370-372)CGG>CGA	p.R124R		NM_032246	NP_115622	Q6ZN04	MEX3B_HUMAN	mex-3 homolog B	124	KH 1.				protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(1)|kidney(1)	2						TGATCTCCCTCCGAGCCATGG	0.622			NA											6	19					0	0	0.00308	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84582127	84582127	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:84582127G>T	uc002bjz.3	+	16	2208	c.1984G>T	c.(1984-1986)GGA>TGA	p.G662*	ADAMTSL3_uc010bmt.1_Nonsense_Mutation_p.G662*|ADAMTSL3_uc010bmu.1_Nonsense_Mutation_p.G662*	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	662						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			AACATGCGTGGGAGGTATTTG	0.488			NA											13	13					4.3838e-07	5.33905e-07	0.001855	1	0
ADAMTSL3	57188	broad.mit.edu	37	15	84611388	84611388	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:84611388G>T	uc002bjz.3	+	18	2382	c.2158G>T	c.(2158-2160)GGA>TGA	p.G720*	ADAMTSL3_uc010bmt.1_Nonsense_Mutation_p.G720*|ADAMTSL3_uc010bmu.1_Nonsense_Mutation_p.G720*	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	720	TSP type-1 5.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGCTACCTGTGGAGTTGGAAT	0.542			NA											43	31					3.4345e-17	5.53357e-17	0.002852	1	0
ADAMTSL3	57188	broad.mit.edu	37	15	84659891	84659891	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:84659891C>A	uc002bjz.3	+	23	4122	c.3898C>A	c.(3898-3900)CAT>AAT	p.H1300N	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.H1300N|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.H1300N	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1300	Ig-like C2-type 3.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGAGCACAACCATCTGTCTGT	0.468			NA											52	115					2.0833e-19	3.50948e-19	0.00361	1	0
NTRK3	4916	broad.mit.edu	37	15	88679765	88679765	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:88679765C>A	uc002bme.1	-	7	860	c.698G>T	c.(697-699)GGC>GTC	p.G233V	NTRK3_uc002bmh.2_Missense_Mutation_p.G233V|NTRK3_uc002bmf.1_Missense_Mutation_p.G233V|NTRK3_uc010upl.1_Missense_Mutation_p.G135V|NTRK3_uc010bnh.1_Missense_Mutation_p.G233V|NTRK3_uc002bmg.2_Missense_Mutation_p.G233V	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	233	Ig-like C2-type 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGATCCAGAGCCATTGCAAGT	0.562			NA	T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			19	6					0.00887093	0.00930319	0.008871	1	0
IFT140	9742	broad.mit.edu	37	16	1636199	1636199	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:1636199C>A	uc002cmb.2	-	10	1449	c.1087G>T	c.(1087-1089)GCA>TCA	p.A363S	IFT140_uc002clz.2_Missense_Mutation_p.A14S	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	363								p.A363A(1)		ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				TTGCCCTCTGCCCCGGGGCTG	0.582			NA											26	67					3.01185e-09	3.94467e-09	0.003954	1	0
ABCA3	21	broad.mit.edu	37	16	2334802	2334802	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:2334802C>T	uc002cpy.1	-	24	4393	c.3681G>A	c.(3679-3681)ATG>ATA	p.M1227I	ABCA3_uc010bsk.1_Missense_Mutation_p.M1169I	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	1227	Helical; (Potential).				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				TGATGGTGACCATCAGGAAGG	0.622			NA											10	19					0	0	0.006214	0	0
CCNF	899	broad.mit.edu	37	16	2489405	2489405	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:2489405C>T	uc002cqd.1	+	7	734	c.646C>T	c.(646-648)CAG>TAG	p.Q216*	CCNF_uc002cqe.1_5'UTR	NM_001761	NP_001752	P41002	CCNF_HUMAN	cyclin F	216					cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			central_nervous_system(1)|kidney(1)	2		Ovarian(90;0.17)				GGCTGCTCATCAGGGATGTCT	0.512			NA											6	9					0	0	0.001984	0	0
PRSS22	64063	broad.mit.edu	37	16	2906129	2906129	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:2906129G>C	uc002cry.1	-	3	301	c.235C>G	c.(235-237)CTG>GTG	p.L79V	PRSS22_uc002crz.1_Intron	NM_022119	NP_071402	Q9GZN4	BSSP4_HUMAN	protease, serine, 22 precursor	79	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)	1						CTGGTGAGCAGAGAACCTGCG	0.612			NA											8	28					0	0	0.006214	0	0
FLYWCH1	84256	broad.mit.edu	37	16	2980841	2980841	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:2980841G>T	uc002csd.2	+	4	1119	c.756G>T	c.(754-756)CTG>CTT	p.L252L	FLYWCH1_uc002csb.2_Silent_p.L251L|FLYWCH1_uc002csc.2_Silent_p.L251L|FLYWCH1_uc010bsv.2_5'Flank	NM_032296	NP_115672	Q4VC44	FWCH1_HUMAN	FLYWCH-type zinc finger 1 isoform a	252						nucleus	DNA binding|metal ion binding				0						CCCTGTCACTGCTGAGCCTGC	0.706			NA											6	8					0.00198382	0.00212531	0.001984	1	0
CREBBP	1387	broad.mit.edu	37	16	3777847	3777847	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:3777847C>A	uc002cvv.2	-	31	7405	c.7201G>T	c.(7201-7203)GGG>TGG	p.G2401W	CREBBP_uc002cvw.2_Missense_Mutation_p.G2363W	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	2401					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TCGGGGTTCCCCAAGTGTCCC	0.652			NA	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybsyndrome				32	53					9.78306e-22	1.70377e-21	0.009535	1	0
SNX29	92017	broad.mit.edu	37	16	12492348	12492348	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:12492348G>T	uc002dby.3	+	10	846	c.790G>T	c.(790-792)GAT>TAT	p.D264Y		NM_001080530	NP_001073999	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	264					cell communication		phosphatidylinositol binding			ovary(1)	1						GAGTTTGTCGGATTTTGAAAT	0.488			NA											24	51					1.32181e-22	2.32729e-22	0.007291	1	0
MYH11	4629	broad.mit.edu	37	16	15797965	15797965	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:15797965G>T	uc002ddy.2	-	41	5909	c.5802C>A	c.(5800-5802)ACC>ACA	p.T1934T	MYH11_uc002ddv.2_3'UTR|MYH11_uc002ddw.2_3'UTR|MYH11_uc002ddx.2_Silent_p.T1941T|MYH11_uc010bvg.2_3'UTR|NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1934	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						GAACGAAAGAGGTCTCGTTTC	0.393			NA	T	CBFB	AML								32	61					7.11191e-15	1.09216e-14	0.002836	1	0
ABCC6	368	broad.mit.edu	37	16	16297269	16297269	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:16297269G>A	uc002den.3	-	8	1033	c.996C>T	c.(994-996)CTC>CTT	p.L332L	ABCC6_uc010bvo.2_RNA|ABCC6_uc010uzz.1_Silent_p.L344L	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	332	Extracellular (By similarity).|ABC transmembrane type-1 1.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		GGACTCACCTGAGCAGCTTGG	0.577			NA											10	25					0	0	0.000978	0	0
ACSM5	54988	broad.mit.edu	37	16	20435317	20435317	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:20435317T>A	uc002dhe.2	+	6	994	c.847T>A	c.(847-849)TTC>ATC	p.F283I		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	283					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						CTGGACTCTCTTCTCTGCCTG	0.498			NA											16	103					0	0	0.004007	0	0
DNAH3	55567	broad.mit.edu	37	16	21033322	21033322	+	Nonsense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:21033322G>C	uc010vbe.1	-	40	5747	c.5747C>G	c.(5746-5748)TCA>TGA	p.S1916*		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1916					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TCTCATCATTGAGAAGGCAAG	0.443			NA											12	44					0	0	0.001368	0	0
DNAH3	55567	broad.mit.edu	37	16	21098179	21098179	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:21098179G>T	uc010vbe.1	-	19	2868	c.2868C>A	c.(2866-2868)CAC>CAA	p.H956Q		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	956	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CCTGCTGCCAGTGTCGGTCTT	0.527			NA											63	71					9.21137e-24	1.65415e-23	0.00361	1	0
EEF2K	29904	broad.mit.edu	37	16	22256000	22256000	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:22256000G>T	uc002dki.2	+	3	781	c.296G>T	c.(295-297)TGG>TTG	p.W99L	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	99					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)		CCCGACCCCTGGGCTGAGTTC	0.587	NSCLC(195;1411 2157 20319 27471 51856)		NA											35	45					2.59497e-14	3.9472e-14	0.007835	1	0
ERN2	10595	broad.mit.edu	37	16	23718359	23718359	+	Silent	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:23718359G>C	uc002dma.3	-	5	661	c.492C>G	c.(490-492)CCC>CCG	p.P164P	ERN2_uc010bxp.2_Silent_p.P164P|ERN2_uc010bxq.1_5'UTR	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	116	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		AGCTGCGGCAGGGAGAGGCAT	0.547			NA											10	46					0	0	0.008291	0	0
IL21R	50615	broad.mit.edu	37	16	27455949	27455949	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:27455949G>A	uc002doq.1	+	6	827	c.594G>A	c.(592-594)CTG>CTA	p.L198L	IL21R_uc002dor.1_Silent_p.L198L|IL21R_uc002dos.1_Silent_p.L198L	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	198	Extracellular (Potential).|Fibronectin type-III.				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						GCTATGAGCTGCAGGTGCGGG	0.592			NA	T	BCL6	NHL								51	35					0	0	0.00361	0	0
KIAA0556	23247	broad.mit.edu	37	16	27751537	27751537	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:27751537G>T	uc002dow.2	+	15	1943	c.1919G>T	c.(1918-1920)AGC>ATC	p.S640I		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	640	Potential.									ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						TCGGAAGAAAGCAAAGGCACC	0.562			NA											34	35					1.56442e-22	2.74774e-22	0.002445	1	0
SH2B1	25970	broad.mit.edu	37	16	28880417	28880417	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:28880417G>T	uc002dri.2	+	6	1571	c.1132G>T	c.(1132-1134)GGA>TGA	p.G378*	uc010vct.1_Intron|SH2B1_uc010vdc.1_Nonsense_Mutation_p.G68*|SH2B1_uc002drj.2_Nonsense_Mutation_p.G378*|SH2B1_uc002drk.2_Nonsense_Mutation_p.G378*|SH2B1_uc002drl.2_Nonsense_Mutation_p.G378*|SH2B1_uc010vdd.1_Nonsense_Mutation_p.G42*|SH2B1_uc010vde.1_Nonsense_Mutation_p.G378*|SH2B1_uc002drm.2_Nonsense_Mutation_p.G378*	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	378	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						CCTGAGCCCAGGGTGAGAAGC	0.562			NA											32	31					1.39806e-14	2.13785e-14	0.008361	1	0
SPNS1	83985	broad.mit.edu	37	16	28993752	28993752	+	Silent	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:28993752C>G	uc010vdi.1	+	9	1181	c.1041C>G	c.(1039-1041)CTC>CTG	p.L347L	uc010vct.1_Intron|SPNS1_uc002drx.2_Silent_p.L274L|SPNS1_uc002dsa.2_Silent_p.L347L|SPNS1_uc002drz.2_Silent_p.L295L|SPNS1_uc010byp.2_Silent_p.L273L|SPNS1_uc010byq.1_Silent_p.L279L|LAT_uc010vdj.1_5'Flank|LAT_uc002dsb.2_5'Flank|LAT_uc002dsd.2_5'Flank|LAT_uc002dsc.2_5'Flank|LAT_uc010vdk.1_5'Flank|LAT_uc010vdl.1_5'Flank	NM_001142448	NP_001135920	Q9H2V7	SPNS1_HUMAN	spinster homolog 1 isoform 1	347					lipid transport|transmembrane transport	integral to membrane|mitochondrial inner membrane	protein binding				0						GCCGCCGGCTCCGCCACTCCA	0.657			NA											25	65					0	0	0.007291	0	0
TAOK2	9344	broad.mit.edu	37	16	29996620	29996620	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:29996620G>T	uc002dva.1	+	14	2292	c.1509G>T	c.(1507-1509)CAG>CAT	p.Q503H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Missense_Mutation_p.Q503H|TAOK2_uc002dvc.1_Missense_Mutation_p.Q503H|TAOK2_uc010bzm.1_Missense_Mutation_p.Q510H|TAOK2_uc002dvd.1_Missense_Mutation_p.Q330H	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	503	Potential.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GACAGCACCAGAAGCAGCTGC	0.662			NA											17	44					3.45872e-05	3.95204e-05	0.004007	1	0
TAOK2	9344	broad.mit.edu	37	16	29997038	29997038	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:29997038G>T	uc002dva.1	+	15	2631	c.1848G>T	c.(1846-1848)CAG>CAT	p.Q616H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Missense_Mutation_p.Q616H|TAOK2_uc002dvc.1_Missense_Mutation_p.Q616H|TAOK2_uc010bzm.1_Missense_Mutation_p.Q623H|TAOK2_uc002dvd.1_Missense_Mutation_p.Q443H	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	616					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						TGCTGCGGCAGAAGGAGCAGC	0.662			NA											3	9					0.00909568	0.00949057	0.009096	1	0
SRCAP	10847	broad.mit.edu	37	16	30735460	30735460	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:30735460T>C	uc002dze.1	+	25	5100	c.4715T>C	c.(4714-4716)CTT>CCT	p.L1572P	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.L1367P|SRCAP_uc010bzz.1_Missense_Mutation_p.L1142P	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1572	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CAGGCTTCCCTTCTGGCTCCA	0.602			NA											46	42					0	0	0.00361	0	0
SETD1A	9739	broad.mit.edu	37	16	30975431	30975431	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:30975431G>T	uc002ead.1	+	6	1342	c.656G>T	c.(655-657)CGC>CTC	p.R219L	SETD1A_uc002eae.1_Missense_Mutation_p.R219L	NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	219					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						TCCCGCCGCCGCTCTTCCTCT	0.622			NA											26	47					1.5548e-18	2.57113e-18	0.005443	1	0
SETD1A	9739	broad.mit.edu	37	16	30975533	30975533	+	Missense_Mutation	SNP	G	G	T	rs148087764		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:30975533G>T	uc002ead.1	+	6	1444	c.758G>T	c.(757-759)CGA>CTA	p.R253L	SETD1A_uc002eae.1_Missense_Mutation_p.R253L	NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	253	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						TCCAGCAGCCGACAAGATACC	0.622			NA											43	46					3.54561e-26	6.49652e-26	0.009718	1	0
ITGAX	3687	broad.mit.edu	37	16	31374645	31374645	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:31374645T>A	uc002ebu.1	+	14	1727	c.1660T>A	c.(1660-1662)TAC>AAC	p.Y554N	ITGAX_uc002ebt.2_Missense_Mutation_p.Y554N|ITGAX_uc010vfk.1_Missense_Mutation_p.Y204N	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	554	Extracellular (Potential).|FG-GAP 6.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GGGTGCTGTCTACCTGTTTCA	0.612			NA											31	108					0	0	0.002096	0	0
SLC5A2	6524	broad.mit.edu	37	16	31499727	31499727	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:31499727G>C	uc002ecf.3	+	9	1064	c.1045G>C	c.(1045-1047)GAG>CAG	p.E349Q	SLC5A2_uc010car.2_RNA|C16orf58_uc002ecg.2_RNA	NM_003041	NP_003032	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose	349	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			ovary(1)	1						CGTGGTGCCTGAGGTGTGCAG	0.682			NA											7	12					0	0	0.000978	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32890601	32890601	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:32890601C>A	uc002edh.1	-	5	461	c.285G>T	c.(283-285)TGG>TGT	p.W95C	SLC6A10P_uc002edi.1_RNA					RecName: Full=Transporter;												0						CCTCACCCCACCACGGGTACA	0.587			NA											3	15					0.00909568	0.00949057	0.009096	1	0
SLC6A10P	386757	broad.mit.edu	37	16	32890630	32890630	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:32890630C>A	uc002edh.1	-	5	432	c.256G>T	c.(256-258)GTC>TTC	p.V86F	SLC6A10P_uc002edi.1_RNA					RecName: Full=Transporter;												0						TTTTTGTAGACCAGCGGCTTG	0.488			NA											12	13					4.3838e-07	5.33905e-07	0.001855	1	0
Unknown	0	broad.mit.edu	37	16	33784722	33784722	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:33784722G>T	uc010vgb.1	+	2	131	c.111G>T	c.(109-111)TGG>TGT	p.W37C						RecName: Full=Transporter;												NA						TGTACCCGTGGTGGGGTGAGG	0.592			NA											12	14					1.3612e-06	1.62893e-06	0.003163	1	0
ABCC12	94160	broad.mit.edu	37	16	48167679	48167679	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:48167679C>T	uc002efc.1	-	7	1393	c.1047G>A	c.(1045-1047)CTG>CTA	p.L349L	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA|ABCC12_uc002efe.1_Silent_p.L349L|ABCC12_uc010vgj.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	349	ABC transmembrane type-1 1.|Helical; (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				CGATGGGGGCCAGGGCAGAGT	0.498			NA											13	24					0	0	0.003163	0	0
CES7	221223	broad.mit.edu	37	16	55886934	55886934	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:55886934G>C	uc002eip.2	-	10	1281	c.1132C>G	c.(1132-1134)CCG>GCG	p.P378A	CES7_uc002eio.2_Missense_Mutation_p.P378A|CES7_uc002eiq.2_Missense_Mutation_p.P139A|CES7_uc002eir.2_Missense_Mutation_p.P272A	NM_001143685	NP_001137157	Q6NT32	EST5A_HUMAN	carboxylesterase 7 isoform 1	378						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.229)|Epithelial(162;0.231)		TACTGAGGCGGGATGTGCTGT	0.378			NA											14	34					0	0	0.001855	0	0
BBS2	583	broad.mit.edu	37	16	56536584	56536584	+	Splice_Site	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:56536584C>A	uc002ejd.2	-	8	1174	c.940_splice	c.e8+1	p.I314_splice	BBS2_uc010ccg.2_Missense_Mutation_p.S314I	NM_031885	NP_114091	Q9BXC9	BBS2_HUMAN	Bardet-Biedl syndrome 2 protein						adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			ovary(1)	1						TCCCAATTTACTTTCCCCATC	0.403			NA							Bardet-Biedl_syndrome				33	85					1.60099e-16	2.54253e-16	0.004878	1	0
NLRC5	84166	broad.mit.edu	37	16	57104528	57104528	+	Silent	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:57104528G>C	uc002ekk.1	+	38	4890	c.4665G>C	c.(4663-4665)CTG>CTC	p.L1555L	NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekq.1_Silent_p.L97L|NLRC5_uc002ekr.1_Silent_p.L442L	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1555	LRR 18.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				TAAAGAGGCTGGAGTAAGTAG	0.308			NA											27	49					0	0	0.007291	0	0
CCDC135	84229	broad.mit.edu	37	16	57765153	57765153	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:57765153C>T	uc002emi.2	+	18	2697	c.2608C>T	c.(2608-2610)CAG>TAG	p.Q870*	CCDC135_uc002emj.2_Nonsense_Mutation_p.Q870*|CCDC135_uc002emk.2_Nonsense_Mutation_p.Q805*	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	870						cytoplasm				central_nervous_system(1)	1						GGGGGAGCTCCAGAAAATATT	0.567			NA											14	26					0	0	0.00499	0	0
CDH8	1006	broad.mit.edu	37	16	61687943	61687943	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:61687943C>A	uc002eog.1	-	12	2221	c.1969G>T	c.(1969-1971)GAT>TAT	p.D657Y		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	657	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		ACGTCTTCATCATCTTTGATA	0.403			NA											25	60					1.96895e-08	2.51481e-08	0.00278	1	0
DDX28	55794	broad.mit.edu	37	16	68055793	68055794	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:68055793_68055794CC>AA	uc002evh.1	-	1	2166_2167	c.1312_1313GG>TT	c.(1312-1314)GGA>TTA	p.G438L	DUS2L_uc002evi.2_5'Flank|DUS2L_uc002evj.2_5'Flank|DUS2L_uc010vkk.1_5'Flank	NM_018380	NP_060850	Q9NUL7	DDX28_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28	438	Helicase C-terminal.					mitochondrial nucleoid|nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0116)|Epithelial(162;0.0474)|all cancers(182;0.233)		CTGGAAGATTCCTACCCTCATC	0.515			NA											15	30					0	0	0.004672	0	0
ZFP90	146198	broad.mit.edu	37	16	68598371	68598371	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:68598371G>A	uc010cff.2	+	5	1973	c.1681G>A	c.(1681-1683)GCC>ACC	p.A561T	ZFP90_uc002ewb.2_3'UTR|ZFP90_uc002ewc.2_3'UTR|ZFP90_uc002ewd.2_Missense_Mutation_p.A561T|ZFP90_uc002ewe.2_Missense_Mutation_p.A561T	NM_133458	NP_597715	Q8TF47	ZFP90_HUMAN	zinc finger protein 90	561	C2H2-type 11.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		CTGTGGGAAAGCCTTTAGTCA	0.433			NA											25	61					0	0	0.005443	0	0
HYDIN	54768	broad.mit.edu	37	16	70871670	70871670	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:70871670G>C	uc002ezr.2	-	77	13290	c.13162C>G	c.(13162-13164)CAA>GAA	p.Q4388E	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4389										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				ATGAGTTCTTGATAGTTGATA	0.438			NA											11	22					0	0	0.001855	0	0
HYDIN	54768	broad.mit.edu	37	16	71025201	71025201	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:71025201C>A	uc002ezr.2	-	25	4012	c.3884G>T	c.(3883-3885)GGG>GTG	p.G1295V		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CCTACCCTCCCCATGGAAAGG	0.483			NA											20	43					8.10497e-08	1.01718e-07	0.010504	1	0
HYDIN	54768	broad.mit.edu	37	16	71212912	71212912	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:71212912G>A	uc002ezr.2	-	4	428	c.300C>T	c.(298-300)CCC>CCT	p.P100P	HYDIN_uc010cfz.1_5'UTR|HYDIN_uc002ezv.2_Silent_p.P100P|HYDIN_uc010vmc.1_Silent_p.P117P|HYDIN_uc010vmd.1_Silent_p.P127P|HYDIN_uc002ezw.3_Silent_p.P117P	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	100										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CTGATGGAAAGGGCTGGAATA	0.378			NA											13	42					0	0	0.001855	0	0
Unknown	0	broad.mit.edu	37	16	74425527	74425527	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:74425527T>G	uc010vmt.1	+	6	699	c.698T>G	c.(697-699)GTG>GGG	p.V233G						RecName: Full=Nuclear pore complex-interacting protein-like 2; Flags: Precursor;												NA						CCACCCTCAGTGGATGATAAT	0.507			NA											11	129					0	0	0.00333	0	0
CLEC18B	497190	broad.mit.edu	37	16	74455116	74455116	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:74455116A>C	uc002fct.2	-	1	253	c.53T>G	c.(52-54)CTG>CGG	p.L18R	CLEC18B_uc002fcu.2_Missense_Mutation_p.L18R|CLEC18B_uc010vmu.1_Missense_Mutation_p.L18R|CLEC18B_uc010vmw.1_Missense_Mutation_p.L18R	NM_001011880	NP_001011880	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	18						extracellular region	sugar binding				0						AAGGAGGGCCAGGAGCACAGC	0.682			NA											20	18					0	0	0.001882	0	0
CHST6	4166	broad.mit.edu	37	16	75513075	75513075	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:75513075G>T	uc002fef.2	-	3	832	c.652C>A	c.(652-654)CTG>ATG	p.L218M	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Missense_Mutation_p.L218M	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	218	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						TCACGCGCCAGAGCCTTGGCT	0.721			NA											12	19					7.03913e-09	9.16103e-09	0.001368	1	0
KARS	3735	broad.mit.edu	37	16	75668121	75668121	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:75668121C>A	uc002feq.2	-	7	913	c.865G>T	c.(865-867)GAG>TAG	p.E289*	KARS_uc002fer.2_Nonsense_Mutation_p.E317*|KARS_uc002fes.2_Nonsense_Mutation_p.E133*|KARS_uc010cgz.2_Nonsense_Mutation_p.E133*	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	289					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	ATGTCCAGCTCGTTGTGATAA	0.428			NA											41	71					2.59497e-14	3.9472e-14	0.007835	1	0
KARS	3735	broad.mit.edu	37	16	75668151	75668151	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:75668151C>T	uc002feq.2	-	7	883	c.835G>A	c.(835-837)GTG>ATG	p.V279M	KARS_uc002fer.2_Missense_Mutation_p.V307M|KARS_uc002fes.2_Missense_Mutation_p.V123M|KARS_uc010cgz.2_Missense_Mutation_p.V123M	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	279					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	GGCTTGGCCACGGCTCCCCCT	0.448			NA											32	55					0	0	0.008361	0	0
CDH13	1012	broad.mit.edu	37	16	83065760	83065760	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:83065760C>A	uc002fgx.2	+	3	423	c.303C>A	c.(301-303)CCC>CCA	p.P101P	CDH13_uc010chh.2_Silent_p.P101P|CDH13_uc010vns.1_Silent_p.P148P|CDH13_uc010vnt.1_Intron|CDH13_uc010vnu.1_Silent_p.P101P	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	101					adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		CACGGACCCCCCATGCGGAAG	0.517			NA											10	17					0.000442599	0.000483873	0.006214	1	0
SLC38A8	146167	broad.mit.edu	37	16	84050766	84050766	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:84050766G>A	uc002fhg.1	-	7	932	c.932C>T	c.(931-933)CCC>CTC	p.P311L		NM_001080442	NP_001073911	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	311	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0						GAGCACGATGGGGTAGACAGT	0.532			NA											12	18					0	0	0.001368	0	0
LRRC50	123872	broad.mit.edu	37	16	84199407	84199407	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:84199407G>T	uc002fhl.3	+	7	1063	c.882G>T	c.(880-882)TGG>TGT	p.W294C	LRRC50_uc010vnw.1_Missense_Mutation_p.W42C	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	294	LRRCT.				axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						CGGAGGCCTGGGCTAGGGGAG	0.483			NA							Kartagener_syndrome				27	66					5.60225e-13	8.16829e-13	0.009535	1	0
FOXC2	2303	broad.mit.edu	37	16	86602192	86602192	+	Silent	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:86602192C>G	uc002fjq.2	+	1	1336	c.1251C>G	c.(1249-1251)GCC>GCG	p.A417A		NM_005251	NP_005242	Q99958	FOXC2_HUMAN	forkhead box C2	417	Ala/Pro-rich.|Poly-Ala.				anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding				0						ccggggccgccgcggcGCAGG	0.313			NA							Late-onset_Hereditary_Lymphedema				4	9					0	0	0.009096	0	0
TCF25	22980	broad.mit.edu	37	16	89967134	89967134	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr16:89967134G>T	uc002fpb.2	+	12	1395	c.1313G>T	c.(1312-1314)TGT>TTT	p.C438F	TCF25_uc002fpc.2_Missense_Mutation_p.C203F	NM_014972	NP_055787	Q9BQ70	TCF25_HUMAN	NULP1	438					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		CTCCCTGAGTGTGAGCAGAGC	0.592			NA											20	22					6.33239e-15	9.73486e-15	0.010504	1	0
SPNS2	124976	broad.mit.edu	37	17	4436619	4436619	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:4436619G>A	uc002fxx.2	+	8	1384	c.1170G>A	c.(1168-1170)CTG>CTA	p.L390L		NM_001124758	NP_001118230	Q8IVW8	SPNS2_HUMAN	spinster homolog 2	390					lipid transport|transmembrane transport	integral to membrane					0						GGTGCCGCCTGAAGACCCAGC	0.637			NA											5	24					0	0	0.001168	0	0
GP1BA	2811	broad.mit.edu	37	17	4836761	4836761	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:4836761G>A	uc010vsq.1	+	2	937	c.862G>A	c.(862-864)GAC>AAC	p.D288N	uc002fzn.1_RNA	NM_000173	NP_000164	P07359	GP1BA_HUMAN	platelet glycoprotein Ib alpha polypeptide	288											0						TGATGAAGGTGACACAGACCT	0.517			NA											20	51					0	0	0.001882	0	0
C17orf74	201243	broad.mit.edu	37	17	7330190	7330190	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:7330190C>A	uc002ggw.2	+	3	953	c.880C>A	c.(880-882)CCC>ACC	p.P294T	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	294						integral to membrane					0		Prostate(122;0.157)				CTCTTGGGTCCCCGTGGGGCA	0.677			NA											19	15					1.64113e-05	1.89019e-05	0.010504	1	0
TP53	7157	broad.mit.edu	37	17	7574017	7574017	+	Missense_Mutation	SNP	C	C	A	rs121912664		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:7574017C>A	uc002gim.2	-	10	1204	c.1010G>T	c.(1009-1011)CGC>CTC	p.R337L	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Missense_Mutation_p.R205L|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Missense_Mutation_p.R337L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	337	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R337C(12)|p.0?(7)|p.R337L(5)|p.R337H(2)|p.?(1)|p.I332fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CATCTCGAAGCGCTCACGCCC	0.453	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			11	11					7.03913e-09	9.16103e-09	0.001368	1	0
MYH2	4620	broad.mit.edu	37	17	10433043	10433043	+	Silent	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:10433043T>C	uc010coi.2	-	24	3083	c.2955A>G	c.(2953-2955)ACA>ACG	p.T985T	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.T985T|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	985	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CCATCTCTTCTGTGAGGTTTT	0.478			NA											23	120					0	0	0.00278	0	0
DNAH9	1770	broad.mit.edu	37	17	11513774	11513774	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:11513774T>A	uc002gne.2	+	3	744	c.676T>A	c.(676-678)TAC>AAC	p.Y226N	DNAH9_uc002gnd.1_Missense_Mutation_p.Y226N	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	226	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CAAATGGAGCTACCAAGTCCA	0.403			NA											5	30					0	0	0.000602	0	0
TEKT3	64518	broad.mit.edu	37	17	15212006	15212006	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:15212006A>C	uc002gon.2	-	8	1418	c.1231T>G	c.(1231-1233)TTG>GTG	p.L411V		NM_031898	NP_114104	Q9BXF9	TEKT3_HUMAN	tektin 3	411					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		TCTCGGCACAACTCAATGTTC	0.572			NA											10	56					0	0	0.008291	0	0
MPRIP	23164	broad.mit.edu	37	17	17062136	17062136	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:17062136G>T	uc002gqu.1	+	14	1922	c.1866G>T	c.(1864-1866)CTG>CTT	p.L622L	MPRIP_uc002gqv.1_Silent_p.L622L|MPRIP_uc002gqw.1_Silent_p.L377L	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	622	Interaction with RHOA.					cytoplasm|cytoskeleton	actin binding				0						GCCCAGGGCTGCCTATGAGCG	0.647			NA											17	34					1.15088e-07	1.43066e-07	0.004007	1	0
ALKBH5	54890	broad.mit.edu	37	17	18110155	18110155	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:18110155A>T	uc010cpw.2	+	3	1569	c.878A>T	c.(877-879)GAA>GTA	p.E293V	ALKBH5_uc010cpx.2_RNA	NM_017758	NP_060228	Q6P6C2	ALKB5_HUMAN	alkB, alkylation repair homolog 5	293						integral to membrane	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0	all_neural(463;0.228)					CCCCGGTTGGAAACAAAGTCC	0.552	Ovarian(166;154 1953 40235 46283 46309)		NA											51	143					0	0	0.00361	0	0
TOP3A	7156	broad.mit.edu	37	17	18205586	18205586	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:18205586C>T	uc002gsx.1	-	7	1035	c.806G>A	c.(805-807)AGA>AAA	p.R269K	TOP3A_uc010vxr.1_5'Flank|TOP3A_uc002gsw.1_5'UTR|TOP3A_uc010vxs.1_Missense_Mutation_p.R167K|TOP3A_uc010cqa.1_RNA	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	269					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						ACCTTTAATTCTGTGGAAGAT	0.507			NA											5	23					0	0	0.001168	0	0
ALDH3A2	224	broad.mit.edu	37	17	19575133	19575133	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:19575133A>T	uc002gwb.1	+	9	1528	c.1307A>T	c.(1306-1308)AAC>ATC	p.N436I	ALDH3A2_uc002gwa.1_Missense_Mutation_p.N436I|ALDH3A2_uc010cqr.1_Missense_Mutation_p.N243I|ALDH3A2_uc002gwc.1_Missense_Mutation_p.N436I|ALDH3A2_uc002gwd.1_Missense_Mutation_p.N243I	NM_000382	NP_000373	P51648	AL3A2_HUMAN	aldehyde dehydrogenase 3A2 isoform 2	436	Cytoplasmic.				cellular aldehyde metabolic process|central nervous system development|epidermis development|lipid metabolic process|peripheral nervous system development	endoplasmic reticulum membrane|integral to membrane	3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(2)	2	all_cancers(12;1.39e-05)|all_epithelial(12;0.00158)|Breast(13;0.245)				NADH(DB00157)	GAAGGTGCTAACAAACTCAGA	0.408			NA											57	38					0	0	0.00361	0	0
MAP2K3	5606	broad.mit.edu	37	17	21206509	21206509	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:21206509G>T	uc002gys.2	+	7	796	c.531G>T	c.(529-531)CTG>CTT	p.L177L	MAP2K3_uc002gyt.2_Silent_p.L148L|MAP2K3_uc002gyu.2_Silent_p.L148L	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	177	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		TGCGGGCCCTGGAGCATCTGC	0.627			NA											10	19					1.41608e-15	2.21233e-15	0.001855	1	0
KSR1	8844	broad.mit.edu	37	17	25909746	25909746	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:25909746G>T	uc010crg.2	+	5	629	c.184G>T	c.(184-186)GAC>TAC	p.D62Y	KSR1_uc002gzj.1_Intron	NM_014238	NP_055053	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras	197					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(1)	4	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		GCCTTCCACGGACACCCTCTC	0.662	Esophageal Squamous(88;1120 1336 6324 10502 16832)		NA											18	41					2.37509e-13	3.5127e-13	0.010504	1	0
SPAG5	10615	broad.mit.edu	37	17	26907094	26907094	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:26907094G>T	uc002hbq.2	-	16	2822	c.2730C>A	c.(2728-2730)ACC>ACA	p.T910T	SGK494_uc010waq.1_Silent_p.T315T	NM_006461	NP_006452	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	910					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			central_nervous_system(1)	1	Lung NSC(42;0.00431)					GGTGTTCCTGGGTGGGAGGAC	0.517			NA											20	35					4.47668e-21	7.77756e-21	0.003954	1	0
SDF2	6388	broad.mit.edu	37	17	26982305	26982305	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:26982305C>A	uc002hbw.2	-	2	387	c.348G>T	c.(346-348)CAG>CAT	p.Q116H	SDF2_uc002hbx.2_RNA	NM_006923	NP_008854	Q99470	SDF2_HUMAN	stromal cell-derived factor 2 precursor	116	MIR 2.				protein glycosylation	extracellular space|membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity				0	Lung NSC(42;0.00431)					GCCACCTCACCTGGTTTCCAG	0.483			NA											16	62					1.15088e-07	1.43066e-07	0.004007	1	0
SLFN11	91607	broad.mit.edu	37	17	33690515	33690515	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:33690515G>T	uc010ctp.2	-	4	754	c.312C>A	c.(310-312)TAC>TAA	p.Y104*	SLFN11_uc010ctq.2_Nonsense_Mutation_p.Y104*|SLFN11_uc002hjh.3_Nonsense_Mutation_p.Y104*|SLFN11_uc002hjg.3_Nonsense_Mutation_p.Y104*|SLFN11_uc010ctr.2_Nonsense_Mutation_p.Y104*	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	104						nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TAACAAAAATGTAAAAACACC	0.448			NA											33	44					8.16721e-17	1.30712e-16	0.002096	1	0
STARD3	10948	broad.mit.edu	37	17	37818598	37818598	+	Splice_Site	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:37818598G>T	uc002hsd.2	+	14	1357	c.1233_splice	c.e14+1	p.K411_splice	STARD3_uc010weh.1_Splice_Site|STARD3_uc002hse.2_Splice_Site_p.K393_splice|STARD3_uc010wei.1_Splice_Site_p.K411_splice|STARD3_uc002hsf.2_Splice_Site_p.K277_splice|STARD3_uc002hsg.2_Splice_Site_p.K244_splice	NM_006804	NP_006795	Q14849	STAR3_HUMAN	StAR-related lipid transfer (START) domain						cholesterol metabolic process|mitochondrial transport|steroid biosynthetic process	integral to membrane|late endosome membrane	cholesterol binding|cholesterol transporter activity				0	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			AGATCTCAAGGTGGGGTGCTG	0.592			NA											3	12					0.00024832	0.00027355	0.009096	1	0
KRT27	342574	broad.mit.edu	37	17	38937451	38937451	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:38937451G>T	uc002hvg.2	-	2	557	c.516C>A	c.(514-516)GAC>GAA	p.D172E		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	172	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)				TTAGTCTGAAGTCATCAGCTG	0.333			NA											8	14					5.4927e-09	7.17435e-09	0.004482	1	0
KRTAP9-2	83899	broad.mit.edu	37	17	39383169	39383169	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:39383169C>A	uc002hwf.2	+	1	270	c.263C>A	c.(262-264)CCC>CAC	p.P88H		NM_031961	NP_114167	Q9BYQ4	KRA92_HUMAN	keratin associated protein 9.2	88	17 X 5 AA repeats of C-C-[RQVSGE]-[SPTQ]- [TASP].|11.					keratin filament	protein binding			upper_aerodigestive_tract(1)	1		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			TGCTGCCAGCCCACCTGCTGT	0.617			NA											41	48					4.64027e-19	7.79867e-19	0.00361	1	0
EFTUD2	9343	broad.mit.edu	37	17	42953336	42953336	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:42953336G>A	uc002ihn.2	-	10	1096	c.835C>T	c.(835-837)CGC>TGC	p.R279C	EFTUD2_uc010wje.1_Missense_Mutation_p.R244C|EFTUD2_uc010wjf.1_Missense_Mutation_p.R269C	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	279						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)				ACAATGTGGCGCAGCTTGTAA	0.512	Ovarian(10;65 485 10258 29980 30707)		NA											47	177					0	0	0.002852	0	0
NMT1	4836	broad.mit.edu	37	17	43175843	43175843	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:43175843G>T	uc002ihz.2	+	7	825	c.807G>T	c.(805-807)AGG>AGT	p.R269S	NMT1_uc002iia.2_RNA	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	269					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				AGATCACCAGGCGGGTTCACC	0.527			NA											52	80					1.00221e-16	1.60043e-16	0.00361	1	0
ACBD4	79777	broad.mit.edu	37	17	43213951	43213951	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:43213951G>T	uc002iid.2	+	3	517	c.173G>T	c.(172-174)CGG>CTG	p.R58L	ACBD4_uc010wjj.1_Missense_Mutation_p.R58L|ACBD4_uc002iie.2_Missense_Mutation_p.R58L|ACBD4_uc002iif.2_Missense_Mutation_p.R58L|ACBD4_uc002iic.2_Missense_Mutation_p.R58L|ACBD4_uc010dae.2_5'UTR	NM_001135707	NP_001129179	Q8NC06	ACBD4_HUMAN	acyl-Coenzyme A binding domain containing 4	58	ACB.						fatty-acyl-CoA binding			ovary(1)|kidney(1)	2						CTGGTCCCCCGGCCCGGGTTC	0.607			NA											23	87					3.85864e-22	6.76083e-22	0.00278	1	0
Unknown	0	broad.mit.edu	37	17	45560458	45560458	+	Splice_Site	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:45560458T>C	uc002ilp.1	-	4		c.397_splice	c.e4-1		uc002ilq.2_Splice_Site					Homo sapiens cDNA clone IMAGE:5266250, containing frame-shift errors.												NA						CTCCGGATTCTGTAAAATTAA	0.348			NA											24	37					0	0	0.00361	0	0
HOXB5	3215	broad.mit.edu	37	17	46670529	46670529	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:46670529C>G	uc002inr.2	-	1	575	c.516G>C	c.(514-516)CAG>CAC	p.Q172H	HOXB3_uc010wlm.1_5'Flank|HOXB3_uc010dbf.2_5'Flank|HOXB3_uc010dbg.2_5'Flank	NM_002147	NP_002138	P09067	HXB5_HUMAN	homeobox B5	172						nucleus	sequence-specific DNA binding				0						TTTGCGGAGTCTGCCCCTCGG	0.597			NA											32	46					0	0	0.004878	0	0
ABI3	51225	broad.mit.edu	37	17	47297531	47297531	+	Silent	SNP	C	C	T	rs147987389		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:47297531C>T	uc002iop.1	+	6	1143	c.645C>T	c.(643-645)GGC>GGT	p.G215G	ABI3_uc002ioq.1_Silent_p.G209G	NM_016428	NP_057512	Q9P2A4	ABI3_HUMAN	NESH protein isoform 1	215					cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding				0			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			TGGTGTTCAGCAGCGCCGAAG	0.682			NA								HNSCC(55;0.14)			5	34					0	0	0.001984	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48603308	48603308	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:48603308G>T	uc010wmr.1	+	14	2140	c.1978G>T	c.(1978-1980)GCC>TCC	p.A660S	MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	623					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			GACCCTGCCCGCCAAGGCTGA	0.597			NA											48	121					1.61004e-24	2.90573e-24	0.00361	1	0
KIF2B	84643	broad.mit.edu	37	17	51902405	51902405	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:51902405A>T	uc002iua.2	+	1	2167	c.2011A>T	c.(2011-2013)AAG>TAG	p.K671*	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	671					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CGTGAAGAGCAAGGTAGAGTG	0.438			NA											4	19					0	0	0.000602	0	0
MTMR4	9110	broad.mit.edu	37	17	56572926	56572926	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:56572926C>A	uc002iwj.2	-	16	2687	c.2577G>T	c.(2575-2577)GGG>GGT	p.G859G		NM_004687	NP_004678	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	859						cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TGTCTTCCTCCCCATGGGTCA	0.478			NA											13	63					0.000151284	0.000168068	0.001855	1	0
MTMR4	9110	broad.mit.edu	37	17	56586171	56586171	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:56586171C>T	uc002iwj.2	-	6	435	c.325G>A	c.(325-327)GAG>AAG	p.E109K		NM_004687	NP_004678	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	109						cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GAGAGCCACTCTTGGCACTGC	0.587			NA											9	43					0	0	0.008291	0	0
MED13	9969	broad.mit.edu	37	17	60062082	60062082	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:60062082G>C	uc002izo.2	-	14	2698	c.2621C>G	c.(2620-2622)TCT>TGT	p.S874C		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	874					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TCCTATACTAGAACTATTTCC	0.338			NA											9	58					0	0	0.006214	0	0
ABCA10	10349	broad.mit.edu	37	17	67215830	67215830	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:67215830C>A	uc010dfa.1	-	7	1265	c.386G>T	c.(385-387)GGA>GTA	p.G129V	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfc.1_Missense_Mutation_p.G21V	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	129					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					CATAATTTCTCCCTTAGAAAT	0.313			NA											23	61					4.26978e-12	6.0541e-12	0.00333	1	0
TTYH2	94015	broad.mit.edu	37	17	72227059	72227059	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:72227059G>T	uc002jkc.2	+	3	366	c.335G>T	c.(334-336)AGC>ATC	p.S112I	TTYH2_uc010wqw.1_Missense_Mutation_p.S91I	NM_032646	NP_116035	Q9BSA4	TTYH2_HUMAN	tweety 2 isoform 1	112	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity|protein binding			ovary(3)|large_intestine(1)	4						TATGGAAACAGCGAGACCAAC	0.507			NA											26	52					8.24728e-16	1.29832e-15	0.004656	1	0
TNRC6C	57690	broad.mit.edu	37	17	76047273	76047273	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:76047273G>T	uc002jud.2	+	4	2730	c.2130G>T	c.(2128-2130)TGG>TGT	p.W710C	TNRC6C_uc002juf.2_Missense_Mutation_p.W710C|TNRC6C_uc002jue.2_Missense_Mutation_p.W710C	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	710	Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			CAACTGGCTGGGAAGAACCCT	0.522			NA											7	7					0.000274275	0.000300993	0.004482	1	0
CCDC40	55036	broad.mit.edu	37	17	78055541	78055541	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:78055541A>G	uc010dht.2	+	11	1786	c.1759A>G	c.(1759-1761)AGG>GGG	p.R587G	CCDC40_uc002jxm.3_Missense_Mutation_p.R370G|CCDC40_uc002jxn.3_5'UTR	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	587	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CAATACCTACAGGCTCACCCT	0.642			NA											6	18					0	0	0.001984	0	0
RPTOR	57521	broad.mit.edu	37	17	78681641	78681641	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:78681641G>T	uc002jyt.1	+	4	1154	c.349G>T	c.(349-351)GCC>TCC	p.A117S	RPTOR_uc002jys.2_Missense_Mutation_p.A117S|RPTOR_uc010wuf.1_5'UTR|RPTOR_uc010wug.1_Missense_Mutation_p.A117S	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	117					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						CCTGCAACAGGCCCGGTACAA	0.458			NA											6	33					2.0095e-06	2.38297e-06	0.001984	1	0
TEX19	400629	broad.mit.edu	37	17	80320452	80320452	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr17:80320452C>T	uc002keq.2	+	2	735	c.426C>T	c.(424-426)ACC>ACT	p.T142T		NM_207459	NP_997342	Q8NA77	TEX19_HUMAN	testis expressed 19	142						nucleus					0						CTGACTGGACCCAGGGTCTTC	0.582			NA											35	98					0	0	0.002836	0	0
LAMA1	284217	broad.mit.edu	37	18	7017304	7017304	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:7017304C>A	uc002knm.2	-	20	2875	c.2781G>T	c.(2779-2781)GTG>GTT	p.V927V	LAMA1_uc010wzj.1_Silent_p.V403V	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	927	Laminin EGF-like 9.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCTGTCCAGTCACGTTTGGTT	0.498			NA											7	45					0.00448238	0.0047387	0.004482	1	0
LAMA1	284217	broad.mit.edu	37	18	7034485	7034485	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:7034485G>T	uc002knm.2	-	14	2138	c.2044C>A	c.(2044-2046)CTT>ATT	p.L682I	LAMA1_uc010wzj.1_Missense_Mutation_p.L158I	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	682	Laminin IV type A 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TACCTGTAAAGAGCCATTTTT	0.363			NA											41	9					3.4597e-24	6.23611e-24	0.00361	1	0
CTAGE1	64693	broad.mit.edu	37	18	19996204	19996204	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:19996204C>T	uc002ktv.1	-	1	1675	c.1571G>A	c.(1570-1572)GGA>GAA	p.G524E		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	524						integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					GCCTCTTCCTCCTCCCCGTGG	0.512			NA											15	83					0	0	0.007413	0	0
ZNF521	25925	broad.mit.edu	37	18	22807555	22807555	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:22807555C>A	uc002kvk.2	-	4	574	c.327G>T	c.(325-327)GAG>GAT	p.E109D	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.E109D|ZNF521_uc002kvl.2_Translation_Start_Site	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	109					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					CACCTTCTTCCTCTCCAAAAT	0.517			NA	T	PAX5	ALL								48	39					1.81118e-26	3.32704e-26	0.00361	1	0
DSC2	1824	broad.mit.edu	37	18	28667691	28667691	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:28667691T>A	uc002kwl.3	-	6	1170	c.716A>T	c.(715-717)AAC>ATC	p.N239I	DSC2_uc002kwk.3_Missense_Mutation_p.N239I	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	239	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			AATTGGGTAGTTATCATTTTC	0.343			NA											29	61					0	0	0.00632	0	0
DSG4	147409	broad.mit.edu	37	18	28991352	28991352	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:28991352C>A	uc002kwq.2	+	15	2431	c.2296C>A	c.(2296-2298)CTG>ATG	p.L766M	DSG4_uc002kwr.2_Missense_Mutation_p.L785M	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	766	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CATGGGAACCCTGCGGGACTA	0.438			NA											12	51					3.07112e-06	3.6122e-06	0.000978	1	0
ASXL3	80816	broad.mit.edu	37	18	31319240	31319240	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:31319240C>A	uc010dmg.1	+	11	1927	c.1872C>A	c.(1870-1872)AGC>AGA	p.S624R	ASXL3_uc002kxq.2_Missense_Mutation_p.S331R	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	624	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						CCTGTACCAGCCTGCCTTCTC	0.483			NA											21	14					6.44725e-10	8.56861e-10	0.002299	1	0
ASXL3	80816	broad.mit.edu	37	18	31326557	31326557	+	Nonstop_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:31326557T>C	uc010dmg.1	+	12	6800	c.6745T>C	c.(6745-6747)TAA>CAA	p.*2249Q	ASXL3_uc002kxq.2_Nonstop_Mutation_p.*1956Q	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	2249					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GGTTGTACGATAAGAGCTGAG	0.453			NA											18	66					0	0	0.00278	0	0
DTNA	1837	broad.mit.edu	37	18	32335943	32335943	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:32335943G>C	uc010dmn.1	+	1	4	c.3G>C	c.(1-3)ATG>ATC	p.M1I	DTNA_uc002kxu.2_Missense_Mutation_p.M1I|DTNA_uc010xbx.1_Missense_Mutation_p.M1I|DTNA_uc002kxv.3_Missense_Mutation_p.M1I|DTNA_uc002kxw.2_Missense_Mutation_p.M1I|DTNA_uc002kxx.2_Missense_Mutation_p.M1I|DTNA_uc010dmj.2_Missense_Mutation_p.M1I|DTNA_uc002kxz.2_Missense_Mutation_p.M1I|DTNA_uc002kxy.2_Missense_Mutation_p.M1I|DTNA_uc010dmk.1_RNA|DTNA_uc010dml.2_Missense_Mutation_p.M1I|DTNA_uc002kyb.3_Missense_Mutation_p.M1I|DTNA_uc010dmm.2_Missense_Mutation_p.M1I	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	1	Interaction with MAGEE1 (By similarity).				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						CTCATAGAATGATTGAAGATA	0.378			NA											16	34					0	0	0.007413	0	0
C18orf25	147339	broad.mit.edu	37	18	43796201	43796201	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:43796201C>G	uc002lbw.2	+	2	734	c.355C>G	c.(355-357)CAG>GAG	p.Q119E	C18orf25_uc002lbx.2_Missense_Mutation_p.Q119E	NM_145055	NP_659492	Q96B23	CR025_HUMAN	ARKadia-like 1 isoform a	119										central_nervous_system(2)	2						TGAACCCTCTCAGGCAGAAAC	0.522			NA											35	59					0	0	0.004878	0	0
C18orf25	147339	broad.mit.edu	37	18	43820131	43820131	+	Silent	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:43820131A>G	uc002lbw.2	+	3	1255	c.876A>G	c.(874-876)CTA>CTG	p.L292L	C18orf25_uc002lbx.2_Intron	NM_145055	NP_659492	Q96B23	CR025_HUMAN	ARKadia-like 1 isoform a	292										central_nervous_system(2)	2						GCGGGCTTCTAGAGGAGCTGA	0.522			NA											18	20					0	0	0.006122	0	0
CCDC11	220136	broad.mit.edu	37	18	47753781	47753781	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:47753781G>A	uc002lee.2	-	8	1606	c.1515C>T	c.(1513-1515)CGC>CGT	p.R505R		NM_145020	NP_659457	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	505										ovary(1)|pancreas(1)|skin(1)	3				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		GGCATGCCTTGCGCATGGGAT	0.443			NA											12	38					0	0	0.000978	0	0
DCC	1630	broad.mit.edu	37	18	50976902	50976902	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:50976902G>T	uc002lfe.1	+	23	3849	c.3262G>T	c.(3262-3264)GGC>TGC	p.G1088C	DCC_uc010dpf.1_Missense_Mutation_p.G723C	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1088	Extracellular (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CCCCCCGCATGGCAGTGTCAC	0.498			NA											19	35					1.56452e-12	2.2493e-12	0.007413	1	0
TCF4	6925	broad.mit.edu	37	18	52896251	52896251	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:52896251C>T	uc002lfz.2	-	18	2306	c.1694G>A	c.(1693-1695)CGG>CAG	p.R565Q	TCF4_uc002lfw.3_Missense_Mutation_p.R409Q|TCF4_uc010xdu.1_Missense_Mutation_p.R435Q|TCF4_uc010xdv.1_Missense_Mutation_p.R435Q|TCF4_uc002lfx.2_Missense_Mutation_p.R498Q|TCF4_uc010xdw.1_Missense_Mutation_p.R435Q|TCF4_uc002lfy.2_Missense_Mutation_p.R523Q|TCF4_uc010xdx.1_Missense_Mutation_p.R541Q|TCF4_uc010dph.1_Missense_Mutation_p.R569Q|TCF4_uc010xdy.1_Missense_Mutation_p.R545Q|TCF4_uc002lga.2_Missense_Mutation_p.R671Q|TCF4_uc002lgb.1_Missense_Mutation_p.R405Q|TCF4_uc010dpi.2_Missense_Mutation_p.R575Q|TCF4_uc002lfv.2_Missense_Mutation_p.R348Q	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	565	Basic motif.				positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		GGCCATCCTCCGCTCCTTCTC	0.552			NA											34	84					0	0	0.003214	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55024672	55024672	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:55024672G>T	uc002lgn.2	+	3	1188	c.831G>T	c.(829-831)TGG>TGT	p.W277C		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	277	Lumenal (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|skin(1)	2				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		AACTGGCTTGGCCGGGAAATA	0.403			NA											31	76					2.47316e-13	3.65399e-13	0.003271	1	0
ALPK2	115701	broad.mit.edu	37	18	56204009	56204009	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:56204009A>C	uc002lhj.3	-	5	3624	c.3410T>G	c.(3409-3411)GTC>GGC	p.V1137G	ALPK2_uc002lhk.1_Missense_Mutation_p.V468G	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1137							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						CTGCTGCTGGACCCCCTGCTT	0.483			NA											46	92					0	0	0.003214	0	0
ALPK2	115701	broad.mit.edu	37	18	56204016	56204016	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:56204016G>T	uc002lhj.3	-	5	3617	c.3403C>A	c.(3403-3405)CAG>AAG	p.Q1135K	ALPK2_uc002lhk.1_Missense_Mutation_p.Q466K	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1135							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						TGGACCCCCTGCTTTGTTTCA	0.478			NA											48	101					1.02067e-35	1.9315e-35	0.00361	1	0
TNFRSF11A	8792	broad.mit.edu	37	18	60036668	60036668	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:60036668G>T	uc002lin.2	+	9	1556	c.1518G>T	c.(1516-1518)AGG>AGT	p.R506S	TNFRSF11A_uc010dpv.2_Intron	NM_003839	NP_003830	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily,	506	Cytoplasmic (Potential).				adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(2)|lung(1)	3		Colorectal(73;0.188)				GCTCAGCGAGGGCAGGTGCCG	0.627			NA							Paget_Disease_of_Bone				13	30					1.49906e-05	1.72931e-05	0.00245	1	0
BCL2	596	broad.mit.edu	37	18	60985850	60985850	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:60985850T>A	uc002lit.1	-	2	543	c.50A>T	c.(49-51)AAG>ATG	p.K17M	BCL2_uc002liu.1_Missense_Mutation_p.K17M|BCL2_uc002liv.1_Missense_Mutation_p.K17M	NM_000633	NP_000624	P10415	BCL2_HUMAN	B-cell lymphoma protein 2 alpha isoform	17	BH4.				activation of pro-apoptotic gene products|anti-apoptosis|apoptosis in response to endoplasmic reticulum stress|B cell proliferation|B cell receptor signaling pathway|defense response to virus|female pregnancy|humoral immune response|induction of apoptosis by intracellular signals|negative regulation of cellular pH reduction|negative regulation of mitochondrial depolarization|negative regulation of neuron apoptosis|neuron apoptosis|positive regulation of B cell proliferation|positive regulation of cell growth|protein polyubiquitination|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|regulation of transmembrane transporter activity|release of cytochrome c from mitochondria|response to cytokine stimulus|response to DNA damage stimulus|response to drug|response to iron ion|response to nicotine|response to toxin	endoplasmic reticulum membrane|mitochondrial outer membrane|nuclear membrane|pore complex	BH3 domain binding|channel activity|protease binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)	1		all_hematologic(56;1.18e-20)|Prostate(75;0.0872)		Lung(128;0.0234)|READ - Rectum adenocarcinoma(59;0.0935)	Docetaxel(DB01248)|Fludarabine(DB01073)|Melatonin(DB01065)|Paclitaxel(DB01229)|Rasagiline(DB01367)	ATGGATGTACTTCATCACTAT	0.498			NA	T	IGH@	NHL|CLL								26	58					0	0	0.00632	0	0
CNDP2	55748	broad.mit.edu	37	18	72173175	72173175	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:72173175A>G	uc002llm.1	+	4	458	c.296A>G	c.(295-297)CAC>CGC	p.H99R	CNDP2_uc002lln.1_Intron|CNDP2_uc002llo.2_Missense_Mutation_p.H99R|CNDP2_uc002llp.1_5'Flank	NM_018235	NP_060705	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2	99		Manganese 2 (By similarity).				cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			ovary(2)|skin(1)	3		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		ATTTACGGGCACCTGGATGTG	0.662			NA											11	38					0	0	0.001368	0	0
ZNF407	55628	broad.mit.edu	37	18	72344865	72344865	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr18:72344865G>T	uc002llw.2	+	1	1947	c.1890G>T	c.(1888-1890)GTG>GTT	p.V630V	ZNF407_uc010xfc.1_Silent_p.V630V|ZNF407_uc010dqu.1_Silent_p.V630V|ZNF407_uc002llu.2_Silent_p.V629V	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	630	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		AAAAAGATGTGGAAGAACACA	0.358			NA											22	61					2.89027e-11	3.99594e-11	0.002299	1	0
THEG	51298	broad.mit.edu	37	19	375944	375944	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:375944G>T	uc002lol.2	-	1	66	c.27C>A	c.(25-27)CTC>CTA	p.L9L	THEG_uc002lom.2_Silent_p.L9L	NM_016585	NP_057669	Q9P2T0	THEG_HUMAN	Theg homolog isoform 1	9					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			ovary(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGGTTCCCGAGTGACCTTC	0.687			NA											10	15					3.86212e-05	4.37828e-05	0.008291	1	0
CDC34	997	broad.mit.edu	37	19	537015	537015	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:537015C>T	uc002lov.2	+	4	564	c.365C>T	c.(364-366)ACC>ATC	p.T122I		NM_004359	NP_004350	P49427	UB2R1_HUMAN	ubiquitin-conjugating enzyme Cdc34	122					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|negative regulation of cAMP-mediated signaling|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination	cytoplasm|nucleus	ATP binding|protein binding|ubiquitin-protein ligase activity				0		all_cancers(10;1.94e-35)|all_epithelial(18;5.94e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCCACAGGACCATTCTCCTG	0.647			NA											20	39					0	0	0.007413	0	0
APC2	10297	broad.mit.edu	37	19	1453291	1453291	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:1453291G>T	uc002lsr.1	+	3	395	c.187G>T	c.(187-189)GTG>TTG	p.V63L	APC2_uc002lss.1_5'UTR|APC2_uc002lst.1_Missense_Mutation_p.V63L|APC2_uc002lsu.1_Missense_Mutation_p.V63L	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	63					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAGGCCCGAGTGCTGGTGTC	0.687			NA											2	0					0.00024832	0.00027355	0.009096	1	0
ATP8B3	148229	broad.mit.edu	37	19	1795942	1795942	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:1795942C>G	uc002ltw.2	-	18	2221	c.1987G>C	c.(1987-1989)GAC>CAC	p.D663H	ATP8B3_uc002ltv.2_Missense_Mutation_p.D616H|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	663	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGACCGTGTCGGCGCCCTTG	0.617			NA									OREG0025127	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	14					0	0	0.004656	0	0
VAV1	7409	broad.mit.edu	37	19	6773018	6773018	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:6773018C>A	uc002mfu.1	+	1	297	c.200C>A	c.(199-201)TCC>TAC	p.S67Y	VAV1_uc010xjh.1_Missense_Mutation_p.S67Y|VAV1_uc010dva.1_Missense_Mutation_p.S67Y	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	67	Leu-rich.|CH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						CCCCAGATGTCCCAGGTGAGC	0.667			NA											33	23					1.69901e-12	2.44021e-12	0.005524	1	0
MUC16	94025	broad.mit.edu	37	19	9059308	9059308	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:9059308C>A	uc002mkp.2	-	3	28342	c.28138G>T	c.(28138-28140)GGT>TGT	p.G9380C		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9382	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTAAAGGTACCCTGCGAGGTA	0.507			NA											54	24					6.3237e-29	1.17208e-28	0.00361	1	0
MUC16	94025	broad.mit.edu	37	19	9082425	9082425	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:9082425G>T	uc002mkp.2	-	1	9594	c.9390C>A	c.(9388-9390)CCC>CCA	p.P3130P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3131	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGGTTCTGTGGGAGAAGAGA	0.488			NA											27	57					3.01185e-09	3.94467e-09	0.003954	1	0
RDH8	50700	broad.mit.edu	37	19	10132014	10132014	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:10132014G>A	uc002mmr.2	+	5	869	c.620G>A	c.(619-621)GGC>GAC	p.G207D		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	207					estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	GAGTTCCCAGGCACTGACCCT	0.612			NA											57	23					0	0	0.00361	0	0
S1PR5	53637	broad.mit.edu	37	19	10625538	10625538	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:10625538G>A	uc002mot.1	-	2	207	c.150C>T	c.(148-150)ATC>ATT	p.I50I	S1PR5_uc002mou.1_Silent_p.I50I	NM_030760	NP_110387	Q9H228	S1PR5_HUMAN	endothelial differentiation, sphingolipid	50	Helical; Name=1; (By similarity).					integral to membrane|plasma membrane	lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|pancreas(1)	2						TCTCTAGCACGATGAAGGCGC	0.662			NA											11	6					0	0	0.008291	0	0
DOCK6	57572	broad.mit.edu	37	19	11363464	11363464	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:11363464C>A	uc002mqs.3	-	3	344	c.303G>T	c.(301-303)AAG>AAT	p.K101N		NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	101					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						CCCACTCATCCTTGGGGATCC	0.542			NA											23	8					4.22769e-11	5.82824e-11	0.00632	1	0
C19orf39	126074	broad.mit.edu	37	19	11486600	11486600	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:11486600C>T	uc002mrg.1	+	2	635	c.598C>T	c.(598-600)CGA>TGA	p.R200*		NM_175871	NP_787067	Q6NVH7	CS039_HUMAN	hypothetical protein LOC126074	200											0						GGTGACTTTCCGATCAGATGG	0.617			NA											5	13					0	0	0.000602	0	0
ZNF653	115950	broad.mit.edu	37	19	11597835	11597835	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:11597835G>A	uc002mrz.1	-	5	1363	c.1310C>T	c.(1309-1311)GCC>GTC	p.A437V		NM_138783	NP_620138	Q96CK0	ZN653_HUMAN	zinc finger protein 653	437					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATAGATGATGGCTGACATGTC	0.677	Pancreas(83;980 1446 4542 6441 43352)		NA											14	23					0	0	0.00245	0	0
GLT25D1	79709	broad.mit.edu	37	19	17688833	17688833	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:17688833C>G	uc002nhc.1	+	9	1213	c.1201C>G	c.(1201-1203)CAC>GAC	p.H401D	GLT25D1_uc010eax.1_Missense_Mutation_p.H129D|GLT25D1_uc010eay.1_5'Flank	NM_024656	NP_078932	Q8NBJ5	GT251_HUMAN	glycosyltransferase 25 domain containing 1	401					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity				0						GGACCCCTACCACGGCCGGCC	0.632			NA											18	16					0	0	0.010504	0	0
ZNF99	7652	broad.mit.edu	37	19	22939922	22939922	+	Silent	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:22939922T>C	uc010xrh.1	-	6	2409	c.2409A>G	c.(2407-2409)AAA>AAG	p.K803K		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ATTCTCCACATTTGTAGGGCT	0.388			NA											4	58					0	0	0.009096	0	0
ZNF91	7644	broad.mit.edu	37	19	23545248	23545248	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:23545248C>T	uc002nre.2	-	4	646	c.533G>A	c.(532-534)GGA>GAA	p.G178E	ZNF91_uc010xrj.1_Missense_Mutation_p.G146E	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	178						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GCATTTCTTTCCAGTATGTCT	0.318			NA											14	7					0	0	0.004007	0	0
ZNF675	171392	broad.mit.edu	37	19	23837472	23837472	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:23837472T>A	uc002nri.2	-	4	445	c.263A>T	c.(262-264)GAG>GTG	p.E88V		NM_138330	NP_612203	Q8TD23	ZN675_HUMAN	zinc finger protein 675	88					bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TATGTTCTGCTCTGGCCAAAA	0.308			NA											10	23					0	0	0.008291	0	0
ZNF536	9745	broad.mit.edu	37	19	30934697	30934697	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:30934697C>A	uc002nsu.1	+	2	366	c.228C>A	c.(226-228)CCC>CCA	p.P76P	ZNF536_uc010edd.1_Silent_p.P76P	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	76					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCGGCCAGCCCATGGGCAGTC	0.682			NA											9	23					0.00448238	0.0047387	0.004482	1	0
ZNF536	9745	broad.mit.edu	37	19	30936096	30936096	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:30936096C>G	uc002nsu.1	+	2	1765	c.1627C>G	c.(1627-1629)CCG>GCG	p.P543A	ZNF536_uc010edd.1_Missense_Mutation_p.P543A	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	543					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TAAAGAGCATCCGCTGCAGCG	0.572			NA											26	49					0	0	0.00333	0	0
TSHZ3	57616	broad.mit.edu	37	19	31767730	31767730	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:31767730G>C	uc002nsy.3	-	2	3034	c.2969C>G	c.(2968-2970)ACG>AGG	p.T990R		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	990	C2H2-type 4.				negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					ACTGATGTACGTGGAAGGAGT	0.483			NA											13	33					0	0	0.001368	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769005	31769005	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:31769005C>G	uc002nsy.3	-	2	1759	c.1694G>C	c.(1693-1695)GGC>GCC	p.G565A		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	565					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CCCCGACGAGCCCAGGGACAA	0.587			NA											35	57					0	0	0.003271	0	0
SLC7A9	11136	broad.mit.edu	37	19	33353074	33353074	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:33353074C>A	uc002ntv.3	-	6	771	c.654G>T	c.(652-654)GTG>GTT	p.V218V	SLC7A9_uc002ntt.3_Intron|SLC7A9_uc002ntu.3_Silent_p.V218V|SLC7A9_uc002ntw.3_Intron	NM_001126335	NP_001119807	P82251	BAT1_HUMAN	solute carrier family 7, member 9	218	Helical; (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			skin(1)	1	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	TGATGGCTCCCACAGACAGCT	0.542	GBM(181;1335 2108 9644 44178 46689)		NA											16	50					4.14922e-12	5.89475e-12	0.004007	1	0
ZNF565	147929	broad.mit.edu	37	19	36673763	36673763	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:36673763C>A	uc002odn.2	-	5	1213	c.1105G>T	c.(1105-1107)GGG>TGG	p.G369W	ZNF565_uc010ees.2_Missense_Mutation_p.G304W|ZNF565_uc002odo.2_Missense_Mutation_p.G369W	NM_152477	NP_689690	Q8N9K5	ZN565_HUMAN	zinc finger protein 565	369	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.206)			AAGGCCTTCCCACATTCCTTA	0.488			NA											20	48					5.26018e-13	7.68508e-13	0.001882	1	0
ZNF607	84775	broad.mit.edu	37	19	38189824	38189824	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:38189824C>A	uc002ohc.1	-	5	1804	c.1208G>T	c.(1207-1209)AGG>ATG	p.R403M	ZNF607_uc002ohb.1_Missense_Mutation_p.R402M	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	403	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			TGAATTGAGCCTAAAGGACTT	0.423			NA											26	59					8.24728e-16	1.29832e-15	0.004656	1	0
RASGRP4	115727	broad.mit.edu	37	19	38910548	38910548	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:38910548C>T	uc002oir.2	-	6	829	c.615G>A	c.(613-615)CTG>CTA	p.L205L	RASGRP4_uc010efz.1_RNA|RASGRP4_uc010ega.1_RNA|RASGRP4_uc010xua.1_Silent_p.L205L|RASGRP4_uc010xub.1_Silent_p.L205L|RASGRP4_uc010xuc.1_Silent_p.L205L|RASGRP4_uc010xud.1_Silent_p.L205L|RASGRP4_uc010xue.1_Silent_p.L205L|RASGRP4_uc010egb.2_Silent_p.L191L	NM_170604	NP_733749	Q8TDF6	GRP4_HUMAN	RAS guanyl releasing protein 4 isoform a	205	Ras-GEF.				activation of phospholipase C activity|cell growth|cell proliferation|myeloid cell differentiation|positive regulation of Ras protein signal transduction|regulation of G-protein coupled receptor protein signaling pathway|response to extracellular stimulus|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|membrane fraction|plasma membrane|soluble fraction	diacylglycerol binding|GTP-dependent protein binding|metal ion binding|Ras guanyl-nucleotide exchange factor activity			pancreas(1)|lung(1)|skin(1)	3	all_cancers(60;4.21e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GGTGCTGAGCCAGCTCCCCCG	0.647			NA											6	5					0	0	0.001168	0	0
FBL	2091	broad.mit.edu	37	19	40331129	40331129	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:40331129G>C	uc002omn.2	-	3	322	c.208C>G	c.(208-210)CGG>GGG	p.R70G	FBL_uc002omm.1_5'UTR|FBL_uc002omo.2_Missense_Mutation_p.R69G|FBL_uc010egr.2_Missense_Mutation_p.R70G	NM_001436	NP_001427	P22087	FBRL_HUMAN	fibrillarin	70	DMA/Gly-rich.				rRNA processing|tRNA processing	box C/D snoRNP complex|Cajal body	methyltransferase activity|protein binding|RNA binding			ovary(1)	1	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)		CCACGACCCCGGTTGCCACCA	0.592			NA											70	157					0	0	0.00361	0	0
FCGBP	8857	broad.mit.edu	37	19	40395889	40395889	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:40395889T>C	uc002omp.3	-	15	7516	c.7508A>G	c.(7507-7509)AAT>AGT	p.N2503S		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	2503	VWFD 6.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GACTCGCCCATTACCCCAGGC	0.622			NA											31	25					0	0	0.00361	0	0
FCGBP	8857	broad.mit.edu	37	19	40433917	40433917	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:40433917C>A	uc002omp.3	-	2	360	c.352G>T	c.(352-354)GTG>TTG	p.V118L		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	118	IgGFc-binding.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			AGTGCCTGCACAGAGATGGCA	0.577			NA											12	25					1.61879e-10	2.19183e-10	0.001368	1	0
CYP2B6	1555	broad.mit.edu	37	19	41515938	41515938	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:41515938C>A	uc002opr.1	+	6	869	c.862C>A	c.(862-864)CTC>ATC	p.L288I	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Intron	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	288					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	CCACCAGAACCTCAACCTCAA	0.552			NA											14	40					3.45872e-05	3.95204e-05	0.004007	1	0
HNRNPUL1	11100	broad.mit.edu	37	19	41774165	41774165	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:41774165C>A	uc002oqb.3	+	2	622	c.333C>A	c.(331-333)TAC>TAA	p.Y111*	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Nonsense_Mutation_p.Y11*|HNRNPUL1_uc002oqa.3_Nonsense_Mutation_p.Y11*|HNRNPUL1_uc010ehm.2_Nonsense_Mutation_p.Y111*|HNRNPUL1_uc002oqc.3_Nonsense_Mutation_p.Y68*|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Nonsense_Mutation_p.Y11*|HNRNPUL1_uc010ehn.2_Nonsense_Mutation_p.Y11*|HNRNPUL1_uc010eho.2_Nonsense_Mutation_p.Y11*|HNRNPUL1_uc010xvy.1_Nonsense_Mutation_p.Y11*|HNRNPUL1_uc010ehl.1_Nonsense_Mutation_p.Y11*	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	111					nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						ACCAATTCTACGATACCCAAG	0.453			NA											13	29					0.00244969	0.00261664	0.00245	1	0
GRIK5	2901	broad.mit.edu	37	19	42510043	42510043	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:42510043T>G	uc002osj.1	-	16	2130	c.2095A>C	c.(2095-2097)AGC>CGC	p.S699R	GRIK5_uc002osi.1_Missense_Mutation_p.S271R	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	699	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	ACGAACACGCTGGGCTGCTTC	0.577			NA											6	10					0	0	0.001984	0	0
PSG6	5675	broad.mit.edu	37	19	43585324	43585324	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:43585324C>T	uc002ovi.2	-	2	232	c.139G>A	c.(139-141)GAG>AAG	p.E47K	PSG6_uc010xwk.1_Intron|PSG2_uc002ovr.2_Missense_Mutation_p.E47K|PSG2_uc002ovq.3_Missense_Mutation_p.E47K|PSG2_uc010eiq.1_Missense_Mutation_p.E47K|PSG2_uc002ovs.3_Missense_Mutation_p.E47K|PSG2_uc002ovt.3_Missense_Mutation_p.E47K			Q00889	PSG6_HUMAN	SubName: Full=Putative uncharacterized protein PSG6;	47	Ig-like V-type.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				TCCTTCCCCTCGGAAACTTTT	0.483			NA											55	128					0	0	0.00361	0	0
PSG4	5672	broad.mit.edu	37	19	43702187	43702187	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:43702187C>T	uc002ovy.2	-	3	773	c.671G>A	c.(670-672)AGT>AAT	p.S224N	PSG6_uc010xwk.1_Missense_Mutation_p.S63N|PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Intron|PSG4_uc002ovz.2_Missense_Mutation_p.S224N	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	224	Ig-like C2-type 1.				defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				GCGGCTGGCACTCACTGGGTT	0.517			NA											67	136					0	0	0.00361	0	0
IRGC	56269	broad.mit.edu	37	19	44223494	44223494	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:44223494A>G	uc002oxh.2	+	2	931	c.784A>G	c.(784-786)ATG>GTG	p.M262V		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	262						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				GAAGAAGGCCATGCTTCAAGA	0.662	Colon(189;350 2037 11447 13433 38914)		NA											10	18					0	0	0.006214	0	0
ZNF222	7673	broad.mit.edu	37	19	44536757	44536757	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:44536757G>C	uc002oyc.2	+	4	1113	c.930G>C	c.(928-930)CAG>CAC	p.Q310H	ZNF284_uc010ejd.2_Intron|ZNF222_uc002oye.2_Missense_Mutation_p.Q350H|ZNF222_uc002oyd.2_Missense_Mutation_p.Q256H	NM_013360	NP_037492	Q9UK12	ZN222_HUMAN	zinc finger protein 222 isoform 2	310					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Prostate(69;0.0435)				ATATGGGACAGAAACCATATA	0.393			NA											13	190					0	0	0.001855	0	0
ZNF226	7769	broad.mit.edu	37	19	44679853	44679853	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:44679853G>T	uc002oyp.2	+	6	582	c.438G>T	c.(436-438)GAG>GAT	p.E146D	ZNF226_uc002oyq.2_Missense_Mutation_p.E29D|ZNF226_uc002oyr.2_Missense_Mutation_p.E29D|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Missense_Mutation_p.E146D|ZNF226_uc002oyt.2_Missense_Mutation_p.E146D	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				CTGAAGATGAGAACTATATAG	0.398	Pancreas(115;581 1665 13228 19278 50070)		NA											7	37					8.12818e-05	9.09297e-05	0.001984	1	0
NKPD1	284353	broad.mit.edu	37	19	45655644	45655644	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:45655644G>T	uc010xxi.1	-	4	2051	c.2051C>A	c.(2050-2052)CCC>CAC	p.P684H		NM_198478	NP_940880			NTPase, KAP family P-loop domain containing 1												0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		gcggccctcgggcgcgccccc	0.582			NA											7	2					0.00307968	0.003275	0.00308	1	0
BLOC1S3	388552	broad.mit.edu	37	19	45683049	45683049	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:45683049G>T	uc002pax.3	+	2	591	c.495G>T	c.(493-495)GGG>GGT	p.G165G	TRAPPC6A_uc002pav.2_5'Flank|TRAPPC6A_uc002paw.2_5'Flank	NM_212550	NP_997715	Q6QNY0	BL1S3_HUMAN	biogenesis of lysosomal organelles complex-1,	165					cellular membrane organization|eye development|melanosome organization|platelet activation|platelet dense granule organization|post-Golgi vesicle-mediated transport	BLOC-1 complex	identical protein binding				0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		TGGCGCGCGGGGACCTTTGTG	0.761			NA							Hermansky-Pudlak_syndrome				11	5					3.86212e-05	4.37828e-05	0.008291	1	0
ERCC2	2068	broad.mit.edu	37	19	45858052	45858052	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:45858052C>T	uc002pbj.2	-	17	1648	c.1601G>A	c.(1600-1602)GGC>GAC	p.G534D	ERCC2_uc002pbh.2_Missense_Mutation_p.G97D|ERCC2_uc002pbi.2_Missense_Mutation_p.G227D|ERCC2_uc010ejz.2_Missense_Mutation_p.G456D|ERCC2_uc002pbk.2_Missense_Mutation_p.G510D	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	534	Mediates interaction with MMS19.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		GGCCACGATGCCATCAGGGAC	0.627			NA	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				93	53					0	0	0.00361	0	0
MYPOP	339344	broad.mit.edu	37	19	46404961	46404961	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:46404961T>G	uc002pdt.2	-	2	158	c.71A>C	c.(70-72)GAG>GCG	p.E24A		NM_001012643	NP_001012661	Q86VE0	MYPOP_HUMAN	Myb protein P42POP	24	Myb-like.					nucleus	DNA binding				0						GATCTGGTTCTCTTCGAATGA	0.726			NA											10	3					0	0	0.008291	0	0
CRX	1406	broad.mit.edu	37	19	48343050	48343050	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:48343050G>T	uc002phq.3	+	4	930	c.726G>T	c.(724-726)GTG>GTT	p.V242V		NM_000554	NP_000545	O43186	CRX_HUMAN	cone-rod homeobox protein	242			V -> M (in CORD2).		organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		GCCCCTCCGTGGGACCTTCCC	0.652	Pancreas(57;461 1196 22201 40716 47188)		NA											53	102					2.17126e-26	3.9834e-26	0.00361	1	0
PRR12	57479	broad.mit.edu	37	19	50098208	50098208	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:50098208G>T	uc002poo.3	+	4	616	c.616G>T	c.(616-618)GAG>TAG	p.E206*		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		ACTGGGCTTCGAGCGCCTGGC	0.701			NA											4	2					1.23904e-05	1.4328e-05	0.000602	1	0
TBC1D17	79735	broad.mit.edu	37	19	50387984	50387984	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:50387984G>T	uc002pqo.2	+	13	1565	c.1413G>T	c.(1411-1413)AGG>AGT	p.R471S	TBC1D17_uc010ybg.1_Missense_Mutation_p.R438S|TBC1D17_uc002pqp.2_Missense_Mutation_p.R122S|TBC1D17_uc002pqq.1_RNA|TBC1D17_uc002pqr.2_Missense_Mutation_p.R122S|TBC1D17_uc002pqs.2_RNA	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	471	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		TGCTCCTGAGGGTGCTGGACC	0.607			NA											14	26					8.28177e-16	1.30232e-15	0.007413	1	0
SIGLEC11	114132	broad.mit.edu	37	19	50453299	50453299	+	Silent	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:50453299T>A	uc010ybh.1	-	11	2116	c.2025A>T	c.(2023-2025)ACA>ACT	p.T675T	SIGLEC11_uc010ybi.1_Silent_p.T579T	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	675	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		GGGGCTGTCCTGTGTGGATCT	0.607			NA											7	19					0	0	0.004482	0	0
LRRC4B	94030	broad.mit.edu	37	19	51051798	51051798	+	Splice_Site	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:51051798C>G	uc002pss.2	-	2	434	c.297_splice	c.e2+1	p.Q99_splice		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor							cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		GCCCCGCATACCTGGATGCCG	0.672			NA											2	2					0	0	0.004672	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52004799	52004799	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:52004799C>A	uc002pwx.1	-	1	245	c.189G>T	c.(187-189)TGG>TGT	p.W63C	SIGLEC12_uc002pww.1_5'Flank|SIGLEC12_uc010eoy.1_5'UTR	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	63	Ig-like V-type 1.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CTGCCCGGAACCAGTAGCCAT	0.592			NA											13	17					3.45872e-05	3.95204e-05	0.004007	1	0
LILRA1	11024	broad.mit.edu	37	19	55107848	55107848	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:55107848A>T	uc002qgh.1	+	7	1335	c.1153A>T	c.(1153-1155)AGT>TGT	p.S385C	LILRA2_uc010yfg.1_Missense_Mutation_p.S383C|LILRA1_uc010yfh.1_Missense_Mutation_p.S385C	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	385	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		ATTCCCTATGAGTCCTGTGAC	0.567			NA											39	80					0	0	0.007835	0	0
TNNT1	7138	broad.mit.edu	37	19	55653268	55653268	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:55653268A>T	uc002qjb.3	-	7	238	c.149T>A	c.(148-150)TTG>TAG	p.L50*	TNNT1_uc002qiz.3_5'UTR|TNNT1_uc002qja.3_5'UTR|TNNT1_uc002qjc.3_Nonsense_Mutation_p.L50*|TNNT1_uc002qje.3_Nonsense_Mutation_p.L39*|TNNT1_uc002qjd.3_Nonsense_Mutation_p.L39*|TNNT1_uc002qjf.2_Nonsense_Mutation_p.L46*	NM_003283	NP_003274	P13805	TNNT1_HUMAN	troponin T1, skeletal, slow isoform a	50					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		TGGCGGGATCAAAGGAGGCAC	0.473			NA											42	61					0	0	0.003214	0	0
USP29	57663	broad.mit.edu	37	19	57640451	57640451	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:57640451C>A	uc002qny.2	+	4	764	c.408C>A	c.(406-408)AGC>AGA	p.S136R		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	136					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CATTTTACAGCATTTGTAACA	0.373			NA											13	38					4.3838e-07	5.33905e-07	0.001855	1	0
USP29	57663	broad.mit.edu	37	19	57640799	57640799	+	Silent	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:57640799T>C	uc002qny.2	+	4	1112	c.756T>C	c.(754-756)AAT>AAC	p.N252N		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	252					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATGCCAAAAATGGTTTGACAT	0.468			NA											11	52					0	0	0.008291	0	0
ZNF548	147694	broad.mit.edu	37	19	57909965	57909966	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:57909965_57909966GG>TT	uc002qom.2	+	3	560_561	c.310_311GG>TT	c.(310-312)GGA>TTA	p.G104L	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.G107L	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	104					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGAGCACAATGGAATTCATCCT	0.47			NA											24	45					0	0	0.004672	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58563973	58563973	+	Missense_Mutation	SNP	C	C	A	rs144488549		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:58563973C>A	uc002qrc.1	+	5	828	c.581C>A	c.(580-582)GCG>GAG	p.A194E		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	194					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GAGGCCGAAGCGCCCCGCGCC	0.602			NA											11	31					2.27111e-07	2.78718e-07	0.001368	1	0
MYT1L	23040	broad.mit.edu	37	2	1893222	1893222	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:1893222C>G	uc002qxe.2	-	16	3138	c.2311G>C	c.(2311-2313)GGG>CGG	p.G771R	MYT1L_uc002qxd.2_Missense_Mutation_p.G769R|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	771					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TCCAGGGTCCCGTTCTCATCC	0.597			NA											38	28					0	0	0.002522	0	0
LPIN1	23175	broad.mit.edu	37	2	11964914	11964914	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:11964914G>T	uc010yjn.1	+	21	2944	c.2670G>T	c.(2668-2670)GCG>GCT	p.A890A	LPIN1_uc010yjm.1_Silent_p.A975A|LPIN1_uc002rbt.2_Silent_p.A890A|LPIN1_uc010yjo.1_Silent_p.A391A	NM_145693	NP_663731	Q14693	LPIN1_HUMAN	lipin 1	890					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		CTGCCTCAGCGTAAAATGTCC	0.517			NA											4	34					2.56e-06	3.02584e-06	0.009096	1	0
NBAS	51594	broad.mit.edu	37	2	15496434	15496434	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:15496434C>T	uc002rcc.1	-	33	3950	c.3924G>A	c.(3922-3924)ATG>ATA	p.M1308I	NBAS_uc010exl.1_Missense_Mutation_p.M380I|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1308										ovary(2)|liver(1)|skin(1)	4						CACCTGTGGCCATCAGCTCCT	0.448			NA											14	51					0	0	0.003163	0	0
NBAS	51594	broad.mit.edu	37	2	15514742	15514742	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:15514742C>A	uc002rcc.1	-	31	3719	c.3693G>T	c.(3691-3693)CTG>CTT	p.L1231L	NBAS_uc010exl.1_Silent_p.L303L|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1231										ovary(2)|liver(1)|skin(1)	4						CTTGCAAAGGCAGGATCTTTA	0.378			NA											77	67					2.05912e-35	3.89155e-35	0.00361	1	0
APOB	338	broad.mit.edu	37	2	21229397	21229397	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:21229397G>T	uc002red.2	-	26	10471	c.10343C>A	c.(10342-10344)ACC>AAC	p.T3448N		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3448	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTTTGACTTGGTATTTCCATT	0.378			NA											19	136					1.01871e-10	1.38714e-10	0.008871	1	0
APOB	338	broad.mit.edu	37	2	21229575	21229575	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:21229575T>C	uc002red.2	-	26	10293	c.10165A>G	c.(10165-10167)AGA>GGA	p.R3389G		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3389	Basic (possible receptor binding region).|LDL receptor binding.|Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CCCCTTTTTCTTGTCAATCTT	0.403			NA											21	112					0	0	0.010504	0	0
UBXN2A	165324	broad.mit.edu	37	2	24205808	24205808	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:24205808G>T	uc010exy.2	+	6	798	c.330G>T	c.(328-330)GAG>GAT	p.E110D	UBXN2A_uc002rem.2_RNA|UBXN2A_uc002ren.2_Missense_Mutation_p.E110D|UBXN2A_uc010ykj.1_Missense_Mutation_p.E110D	NM_181713	NP_859064	P68543	UBX2A_HUMAN	UBX domain containing 4	110	SEP.										0						ATAAAGAAGAGGTGGACGTTA	0.358			NA											14	49					3.27435e-08	4.14541e-08	0.00245	1	0
HADHA	3030	broad.mit.edu	37	2	26457193	26457193	+	Silent	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:26457193T>C	uc002rgy.2	-	5	475	c.345A>G	c.(343-345)GAA>GAG	p.E115E	HADHA_uc010yks.1_Silent_p.E28E|HADHA_uc010ykt.1_Silent_p.E28E	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha	115					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	GCTGTGTTACTTCTTGAAGGG	0.388			NA											25	69					0	0	0.007291	0	0
C2orf53	339779	broad.mit.edu	37	2	27361043	27361043	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:27361043G>C	uc002rjb.2	-	3	735	c.155C>G	c.(154-156)TCT>TGT	p.S52C		NM_178553	NP_848648	Q53SZ7	CB053_HUMAN	hypothetical protein LOC339779	52	Pro-rich.										0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGAGTGGAAGAGAACGGTGG	0.582			NA											4	25					0	0	0.009096	0	0
IFT172	26160	broad.mit.edu	37	2	27677520	27677520	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:27677520C>T	uc002rku.2	-	31	3430	c.3379G>A	c.(3379-3381)GAA>AAA	p.E1127K	IFT172_uc010ezb.2_5'Flank	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	1127					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					AACGCAAATTCAAAGGAGCTG	0.443			NA											10	38					0	0	0.008291	0	0
ALK	238	broad.mit.edu	37	2	29551294	29551294	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:29551294C>T	uc002rmy.2	-	6	2243	c.1336G>A	c.(1336-1338)GGG>AGG	p.G446R		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	446	LDL-receptor class A.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	AGGACTGTCCCATTCCAACAA	0.582			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				4	72					0	0	0.009096	0	0
CAPN13	92291	broad.mit.edu	37	2	30974119	30974119	+	Splice_Site	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:30974119T>A	uc002rnn.2	-	11	1264	c.1088_splice	c.e11-1	p.G363_splice	CAPN13_uc002rnp.1_Intron	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13						proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					GAGGTCCTCCTGCATCAGAAA	0.473			NA											18	15					0	0	0.010504	0	0
LTBP1	4052	broad.mit.edu	37	2	33518259	33518259	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:33518259G>T	uc002ros.2	+	20	3148	c.3148G>T	c.(3148-3150)GCA>TCA	p.A1050S	LTBP1_uc002rot.2_Missense_Mutation_p.A724S|LTBP1_uc002rou.2_Missense_Mutation_p.A723S|LTBP1_uc002rov.2_Missense_Mutation_p.A670S|LTBP1_uc010ymz.1_Missense_Mutation_p.A723S|LTBP1_uc010yna.1_Missense_Mutation_p.A670S|LTBP1_uc010ynb.1_5'UTR	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1049	EGF-like 8; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AAACGTCTGCGCAAATGGTGA	0.423			NA											14	21					0.00244969	0.00261664	0.00245	1	0
HEATR5B	54497	broad.mit.edu	37	2	37283695	37283695	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:37283695G>A	uc002rpp.1	-	16	2383	c.2287C>T	c.(2287-2289)CGC>TGC	p.R763C		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	763							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				GCAGGTATGCGTAAATAAATA	0.463			NA											13	112					0	0	0.001368	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656328	40656328	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:40656328G>C	uc002rrx.2	-	1	1117	c.1093C>G	c.(1093-1095)CGC>GGC	p.R365G	SLC8A1_uc002rry.2_Missense_Mutation_p.R365G|SLC8A1_uc002rrz.2_Missense_Mutation_p.R365G|SLC8A1_uc002rsa.2_Missense_Mutation_p.R365G|SLC8A1_uc002rsd.3_Missense_Mutation_p.R365G|SLC8A1_uc002rsb.1_Missense_Mutation_p.R365G|SLC8A1_uc010fan.1_Missense_Mutation_p.R365G|SLC8A1_uc002rsc.1_Missense_Mutation_p.R365G	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	365	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	GCTTGAATGCGATAAAATGCT	0.433			NA											12	66					0	0	0.00245	0	0
ABCG8	64241	broad.mit.edu	37	2	44079810	44079810	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:44079810C>T	uc002rtq.2	+	6	857	c.767C>T	c.(766-768)TCC>TTC	p.S256F	ABCG8_uc010yoa.1_Missense_Mutation_p.S256F	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	256	ABC transporter.|Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				AAGACCTTGTCCAGGCTGGCC	0.572			NA											41	25					0	0	0.006999	0	0
ABCG8	64241	broad.mit.edu	37	2	44079825	44079825	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:44079825G>T	uc002rtq.2	+	6	872	c.782G>T	c.(781-783)GGC>GTC	p.G261V	ABCG8_uc010yoa.1_Missense_Mutation_p.G261V	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	261	ABC transporter.|Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CTGGCCAAAGGCAACCGGCTG	0.562			NA											34	25					3.67414e-24	6.61437e-24	0.002445	1	0
PREPL	9581	broad.mit.edu	37	2	44565657	44565657	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:44565657C>T	uc002ruf.2	-	7	1023	c.988G>A	c.(988-990)GAT>AAT	p.D330N	PREPL_uc002rug.2_Missense_Mutation_p.D330N|PREPL_uc002ruh.2_Intron|PREPL_uc010fax.2_Missense_Mutation_p.D330N|PREPL_uc002rui.3_Missense_Mutation_p.D241N|PREPL_uc002ruj.1_Missense_Mutation_p.D241N|PREPL_uc002ruk.1_Missense_Mutation_p.D330N	NM_006036	NP_006027	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like isoform C	330					proteolysis	cytosol	serine-type endopeptidase activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GCAGGGGTATCAGCCGCTGTT	0.378			NA											8	50					0	0	0.00308	0	0
KLRAQ1	129285	broad.mit.edu	37	2	48725686	48725686	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:48725686A>G	uc002rwm.2	+	17	1932	c.1747A>G	c.(1747-1749)ATG>GTG	p.M583V	KLRAQ1_uc002rwl.2_Missense_Mutation_p.M537V|KLRAQ1_uc002rwk.2_Missense_Mutation_p.M583V|KLRAQ1_uc010yok.1_Missense_Mutation_p.M552V	NM_001135629	NP_001129101	Q6ZMI0	KLRAQ_HUMAN	KLRAQ motif containing 1 isoform 1	583	Potential.									ovary(1)	1						AGAACATTGGATGTTGGAAGC	0.398			NA											8	35					0	0	0.00308	0	0
TSPYL6	388951	broad.mit.edu	37	2	54482321	54482321	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:54482321G>T	uc002rxr.2	-	1	1089	c.968C>A	c.(967-969)TCT>TAT	p.S323Y	ACYP2_uc002rxq.3_Intron	NM_001003937	NP_001003937	Q8N831	TSYL6_HUMAN	TSPY-like 6	323					nucleosome assembly	nucleus					0						AGTGGAAAAAGACACCACTTG	0.468			NA											28	57					8.58068e-18	1.40287e-17	0.007291	1	0
RTN4	57142	broad.mit.edu	37	2	55253785	55253785	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:55253785C>A	uc002rye.2	-	3	1748	c.1450G>T	c.(1450-1452)GGA>TGA	p.G484*	RTN4_uc002ryd.2_Nonsense_Mutation_p.G278*|RTN4_uc002ryf.2_Intron|RTN4_uc002ryg.2_Intron	NM_020532	NP_065393	Q9NQC3	RTN4_HUMAN	reticulon 4 isoform A	484	Cytoplasmic (Potential).				apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			ovary(2)|large_intestine(1)	3						GTAGGATCTCCTAACAAAGGA	0.388			NA											44	88					2.26627e-22	3.97563e-22	0.007835	1	0
PLEK	5341	broad.mit.edu	37	2	68622925	68622925	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:68622925A>C	uc002sen.3	+	9	1192	c.1030A>C	c.(1030-1032)ATG>CTG	p.M344L	PLEK_uc010fde.2_3'UTR	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	344	PH 2.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		AGCCATCCAGATGGCCTCCCG	0.542			NA											4	52					0	0	0.009096	0	0
FIGLA	344018	broad.mit.edu	37	2	71012617	71012617	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:71012617C>A	uc002she.1	-	3	544	c.539G>T	c.(538-540)GGT>GTT	p.G180V		NM_001004311	NP_001004311	Q6QHK4	FIGLA_HUMAN	factor in the germline alpha	180					multicellular organismal development|oocyte development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcription factor complex	DNA binding|transcription factor binding				0						TGCTGGCTCACCACTGCCACC	0.483			NA											101	351					7.15876e-41	1.36728e-40	0.00361	1	0
MCEE	84693	broad.mit.edu	37	2	71337190	71337190	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:71337190T>A	uc002shs.2	-	3	486	c.441A>T	c.(439-441)GAA>GAT	p.E147D		NM_032601	NP_115990	Q96PE7	MCEE_HUMAN	methylmalonyl CoA epimerase precursor	147					fatty acid beta-oxidation|L-methylmalonyl-CoA metabolic process	mitochondrial matrix	methylmalonyl-CoA epimerase activity			ovary(1)	1						TTTTGACCTCTTCACTTAGAC	0.373			NA											10	97					0	0	0.001368	0	0
ACTG2	72	broad.mit.edu	37	2	74143844	74143844	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:74143844G>T	uc002sjw.2	+	8	1061	c.939G>T	c.(937-939)AGG>AGT	p.R313S	ACTG2_uc010fey.2_Missense_Mutation_p.R313S|ACTG2_uc010yrn.1_Missense_Mutation_p.R270S	NM_001615	NP_001606	P63267	ACTH_HUMAN	actin, gamma 2 propeptide	313					muscle contraction	cytoskeleton|cytosol	ATP binding				0						TTGCTGACAGGATGCAGAAGG	0.498			NA											54	40					2.25088e-17	3.64694e-17	0.00361	1	0
CTNNA2	1496	broad.mit.edu	37	2	80085192	80085192	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:80085192G>T	uc010ysh.1	+	3	357	c.352G>T	c.(352-354)GTA>TTA	p.V118L	CTNNA2_uc010yse.1_Missense_Mutation_p.V118L|CTNNA2_uc010ysf.1_Missense_Mutation_p.V118L|CTNNA2_uc010ysg.1_Missense_Mutation_p.V118L	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	118					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						TTGCTCGTCGGTAAAGCGCGG	0.577			NA											8	90					1.06961e-07	1.33771e-07	0.00308	1	0
CTNNA2	1496	broad.mit.edu	37	2	80101463	80101463	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:80101463T>G	uc010ysh.1	+	5	852	c.847T>G	c.(847-849)TTT>GTT	p.F283V	CTNNA2_uc010yse.1_Missense_Mutation_p.F283V|CTNNA2_uc010ysf.1_Missense_Mutation_p.F283V|CTNNA2_uc010ysg.1_Missense_Mutation_p.F283V	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	283					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						TCTTAATGAGTTTGACGTAAG	0.527			NA											12	39					0	0	0.003163	0	0
CTNNA2	1496	broad.mit.edu	37	2	80816542	80816542	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:80816542C>A	uc010ysh.1	+	14	2126	c.2121C>A	c.(2119-2121)AGC>AGA	p.S707R	CTNNA2_uc010yse.1_Missense_Mutation_p.S707R|CTNNA2_uc010ysf.1_Missense_Mutation_p.S707R|CTNNA2_uc010ysg.1_Missense_Mutation_p.S707R|CTNNA2_uc010ysi.1_Missense_Mutation_p.S339R|CTNNA2_uc010ysj.1_Missense_Mutation_p.S36R	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	707					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GGGACGACAGCGGCAATGATA	0.478			NA											18	58					3.32936e-07	4.06514e-07	0.006122	1	0
FABP1	2168	broad.mit.edu	37	2	88425740	88425740	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:88425740C>T	uc002sst.1	-	2	237	c.195G>A	c.(193-195)GTG>GTA	p.V65V	FABP1_uc002ssu.2_Silent_p.V65V	NM_001443	NP_001434	P07148	FABPL_HUMAN	fatty acid binding protein 1, liver	65					organ morphogenesis						0						ATTCCTCCCCCACCGTGAATT	0.532			NA											80	205					0	0	0.00361	0	0
ZNF514	84874	broad.mit.edu	37	2	95818903	95818903	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:95818903C>A	uc002sue.1	-	3	470	c.96G>T	c.(94-96)GAG>GAT	p.E32D	ZNF514_uc002sud.1_Missense_Mutation_p.E105D	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	zinc finger protein 514	32	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCCTGAAGTTCTCCAGCATCA	0.527			NA											39	39					1.04594e-18	1.74768e-18	0.00623	1	0
VWA3B	200403	broad.mit.edu	37	2	98928447	98928447	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:98928447C>A	uc002syo.2	+	27	3951	c.3687C>A	c.(3685-3687)CAC>CAA	p.H1229Q	VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Missense_Mutation_p.H886Q|VWA3B_uc002syp.1_Missense_Mutation_p.H621Q|VWA3B_uc002syq.1_Missense_Mutation_p.H505Q|VWA3B_uc002syr.1_Missense_Mutation_p.H546Q|VWA3B_uc002sys.2_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	1229										ovary(3)|large_intestine(2)|skin(1)	6						GCTCCTCCCACGGCATCAGCT	0.637			NA											5	8					0.00198382	0.00212531	0.001984	1	0
LYG1	129530	broad.mit.edu	37	2	99901279	99901279	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:99901279G>T	uc002szy.2	-	6	588	c.338C>A	c.(337-339)CCT>CAT	p.P113H	MRPL30_uc002szl.1_Intron|LYG1_uc010yvo.1_Missense_Mutation_p.P113H	NM_174898	NP_777558	Q8N1E2	LYG1_HUMAN	lysozyme g-like protein 1 precursor	113					cell wall macromolecule catabolic process|peptidoglycan catabolic process	extracellular region	lysozyme activity				0						TTGAGAGCCAGGGTCCTGCAG	0.517			NA											23	25					9.95505e-16	1.55696e-15	0.002299	1	0
TBC1D8	11138	broad.mit.edu	37	2	101644861	101644861	+	Silent	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:101644861T>C	uc010fiv.2	-	13	2342	c.2211A>G	c.(2209-2211)CCA>CCG	p.P737P	TBC1D8_uc002tau.3_Silent_p.P494P	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	737					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						CTGGGGGCCCTGGGCTGTCCT	0.557			NA											54	35					0	0	0.00361	0	0
IL18RAP	8807	broad.mit.edu	37	2	103040797	103040797	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:103040797G>T	uc002tbx.2	+	5	986	c.502G>T	c.(502-504)GGG>TGG	p.G168W	IL18RAP_uc010fiz.2_Missense_Mutation_p.G26W	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	168	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						cctacttcttgggagcactgg	0.318			NA											39	37					3.09479e-21	5.38321e-21	0.006999	1	0
RGPD3	653489	broad.mit.edu	37	2	107073431	107073431	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:107073431A>T	uc010ywi.1	-	4	458	c.401T>A	c.(400-402)CTA>CAA	p.L134Q		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	134					intracellular transport		binding			ovary(1)	1						GTTTACCTTTAGTTTATAAAT	0.338			NA											57	69					0	0	0.00361	0	0
RGPD4	285190	broad.mit.edu	37	2	108499164	108499164	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:108499164C>A	uc010ywk.1	+	22	5183	c.5101C>A	c.(5101-5103)CAA>AAA	p.Q1701K	RGPD4_uc002tdu.2_Missense_Mutation_p.Q888K|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1701					intracellular transport		binding			skin(2)	2						GGAAAGGAATCAAGAGCAAGA	0.408			NA											25	101					6.32553e-13	9.19498e-13	0.004656	1	0
SLC5A7	60482	broad.mit.edu	37	2	108626928	108626928	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:108626928C>A	uc002tdv.2	+	9	1630	c.1354C>A	c.(1354-1356)CCA>ACA	p.P452T	SLC5A7_uc010ywm.1_Missense_Mutation_p.P205T|SLC5A7_uc010fjj.2_Missense_Mutation_p.P452T|SLC5A7_uc010ywn.1_Missense_Mutation_p.P339T	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	452	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	TGGAGGGGAGCCATATCTGTA	0.448			NA											20	54					1.36565e-18	2.2766e-18	0.00278	1	0
SH3RF3	344558	broad.mit.edu	37	2	110015186	110015186	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:110015186G>T	uc010ywt.1	+	4	1086	c.1086G>T	c.(1084-1086)GCG>GCT	p.A362A		NM_001099289	NP_001092759	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	362							zinc ion binding			ovary(1)	1						GCTCAGGGGCGGTCAGTGCCT	0.632			NA											3	21					0.00024832	0.00027355	0.009096	1	0
BUB1	699	broad.mit.edu	37	2	111431761	111431761	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:111431761C>G	uc002tgc.2	-	3	239	c.127G>C	c.(127-129)GAA>CAA	p.E43Q	BUB1_uc010yxh.1_Missense_Mutation_p.E23Q|BUB1_uc010fkb.2_Missense_Mutation_p.E43Q|BUB1_uc002tgd.2_Missense_Mutation_p.E43Q	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	43	BUB1 N-terminal.|Necessary for kinetochore localization.				apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		ATCAAGTATTCTTTATTCTCA	0.289			NA											10	38					0	0	0.008291	0	0
FBLN7	129804	broad.mit.edu	37	2	112922696	112922696	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:112922696C>A	uc002tho.1	+	3	625	c.354C>A	c.(352-354)AGC>AGA	p.S118R	FBLN7_uc002thn.2_Missense_Mutation_p.S118R|FBLN7_uc010fki.1_Missense_Mutation_p.S118R|FBLN7_uc010fkj.1_Missense_Mutation_p.S118R	NM_153214	NP_694946	Q53RD9	FBLN7_HUMAN	fibulin 7 isoform 1	118	Sushi.				cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			ovary(1)|central_nervous_system(1)	2						GGCCCAGCAGCGTGGTGTGTC	0.577			NA											40	41					5.20837e-25	9.44713e-25	0.00874	1	0
ZC3H6	376940	broad.mit.edu	37	2	113089870	113089870	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:113089870G>T	uc002thq.1	+	12	3769	c.3375G>T	c.(3373-3375)CAG>CAT	p.Q1125H		NM_198581	NP_940983	P61129	ZC3H6_HUMAN	zinc finger CCCH-type domain containing 6	1125							nucleic acid binding|zinc ion binding			ovary(3)|central_nervous_system(1)	4						GTAAGGTTCAGGTCCCAGCAG	0.567			NA											11	26					1.58986e-06	1.8947e-06	0.008291	1	0
POLR1B	84172	broad.mit.edu	37	2	113309351	113309351	+	Splice_Site	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:113309351G>C	uc002thw.2	+	6	1343	c.763_splice	c.e6-1	p.A255_splice	POLR1B_uc010fkn.2_Splice_Site_p.A199_splice|POLR1B_uc002thx.2_Splice_Site_p.A116_splice|POLR1B_uc010fko.2_Splice_Site_p.A255_splice|POLR1B_uc010fkp.2_Intron|POLR1B_uc010yxn.1_Splice_Site_p.A293_splice|POLR1B_uc002thy.2_Splice_Site_p.A116_splice|POLR1B_uc010yxo.1_Splice_Site_p.A32_splice	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	RNA polymerase I polypeptide B isoform 1						termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(1)	1						TTCTATTCTAGGCACTTGTCA	0.308	Ovarian(16;256 576 9537 23969 41147)		NA											26	36					0	0	0.004656	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125281979	125281979	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:125281979C>A	uc002tno.2	+	9	1788	c.1424C>A	c.(1423-1425)CCA>CAA	p.P475Q	CNTNAP5_uc010flu.2_Missense_Mutation_p.P476Q	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	475	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CCCCCGGCTCCAGACAGCACT	0.483			NA											7	22					8.12818e-05	9.09297e-05	0.001984	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125284970	125284970	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:125284970T>A	uc002tno.2	+	10	1947	c.1583T>A	c.(1582-1584)GTT>GAT	p.V528D	CNTNAP5_uc010flu.2_Missense_Mutation_p.V529D	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	528	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CTCATTTCAGTTCAGCAAGGT	0.438			NA											8	62					0	0	0.004482	0	0
GPR148	344561	broad.mit.edu	37	2	131487721	131487721	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:131487721G>T	uc002trv.1	+	1	999	c.997G>T	c.(997-999)GGC>TGC	p.G333C		NM_207364	NP_997247	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	333	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1	Colorectal(110;0.1)					CATGGTCCGGGGCCACCTCCC	0.542			NA											11	14					3.86212e-05	4.37828e-05	0.008291	1	0
LCT	3938	broad.mit.edu	37	2	136575089	136575089	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:136575089C>A	uc002tuu.1	-	6	1540	c.1529G>T	c.(1528-1530)TGG>TTG	p.W510L		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	510	Extracellular (Potential).|4 X approximate repeats.|2.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		CTCATTCTGCCATCCACCATG	0.587			NA											14	36					3.27435e-08	4.14541e-08	0.00245	1	0
LRP1B	53353	broad.mit.edu	37	2	142012104	142012104	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:142012104C>A	uc002tvj.1	-	4	1422	c.450G>T	c.(448-450)GGG>GGT	p.G150G	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	150	Extracellular (Potential).|EGF-like 1.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TACAGCTTCTCCCATCTTCTG	0.353	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			20	34					3.8784e-16	6.12558e-16	0.001882	1	0
KYNU	8942	broad.mit.edu	37	2	143685264	143685264	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:143685264G>T	uc002tvl.2	+	4	457	c.327G>T	c.(325-327)TGG>TGT	p.W109C	KYNU_uc002tvk.2_Missense_Mutation_p.W109C|KYNU_uc010fnm.2_Missense_Mutation_p.W109C	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	109					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	AGCGTCCTTGGATTACAGGAG	0.358			NA											24	103					1.77063e-15	2.75432e-15	0.005443	1	0
ZEB2	9839	broad.mit.edu	37	2	145157509	145157509	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:145157509A>T	uc002tvu.2	-	8	1725	c.1245T>A	c.(1243-1245)TTT>TTA	p.F415L	ZEB2_uc002tvv.2_Missense_Mutation_p.F409L|ZEB2_uc010zbm.1_Missense_Mutation_p.F386L|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Missense_Mutation_p.F444L	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	415						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		CACCATTCATAAAGGGACTAG	0.453	Melanoma(33;1235 1264 5755 16332)		NA											9	43					0	0	0.006214	0	0
ZEB2	9839	broad.mit.edu	37	2	145157512	145157512	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:145157512G>A	uc002tvu.2	-	8	1722	c.1242C>T	c.(1240-1242)CCC>CCT	p.P414P	ZEB2_uc002tvv.2_Silent_p.P408P|ZEB2_uc010zbm.1_Silent_p.P385P|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Silent_p.P443P	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	414						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		CATTCATAAAGGGACTAGTGC	0.453	Melanoma(33;1235 1264 5755 16332)		NA											10	45					0	0	0.006214	0	0
NEB	4703	broad.mit.edu	37	2	152404226	152404226	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:152404226T>A	uc010fnx.2	-	104	15272	c.15081A>T	c.(15079-15081)AAA>AAT	p.K5027N	NEB_uc002txr.2_Missense_Mutation_p.K1450N	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5027	Nebulin 137.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGTCTTTCAGTTTGTGGTACA	0.443			NA											13	19					0	0	0.00245	0	0
NEB	4703	broad.mit.edu	37	2	152410485	152410485	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:152410485C>A	uc010fnx.2	-	98	14571	c.14380G>T	c.(14380-14382)GAC>TAC	p.D4794Y	NEB_uc002txr.2_Missense_Mutation_p.D1217Y	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	4794	Nebulin 131.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCTACCATGTCGGGCACGATG	0.453			NA											26	91					6.32553e-13	9.19498e-13	0.004656	1	0
GALNT13	114805	broad.mit.edu	37	2	155115595	155115595	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:155115595A>T	uc002tyr.3	+	8	1486	c.919A>T	c.(919-921)ACT>TCT	p.T307S	GALNT13_uc002tyt.3_Missense_Mutation_p.T307S|GALNT13_uc010foc.1_Missense_Mutation_p.T126S|GALNT13_uc010fod.2_Missense_Mutation_p.T60S	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	307	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						AGAGATAGGAACTTACGATGC	0.343			NA											15	101					0	0	0.006122	0	0
NR4A2	4929	broad.mit.edu	37	2	157186008	157186008	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:157186008C>A	uc002tyz.3	-	3	1113	c.691G>T	c.(691-693)GGC>TGC	p.G231C	NR4A2_uc002tyx.3_Missense_Mutation_p.G168C|NR4A2_uc010zcf.1_Missense_Mutation_p.G231C|NR4A2_uc010zcg.1_5'Flank	NM_006186	NP_006177	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	231	Pro-rich.				cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						CCCGGGAAGCCCATGGACGCG	0.721			NA											9	17					2.17888e-05	2.49757e-05	0.006214	1	0
PKP4	8502	broad.mit.edu	37	2	159519545	159519545	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:159519545C>T	uc002tzv.2	+	14	2608	c.2348C>T	c.(2347-2349)CCA>CTA	p.P783L	PKP4_uc002tzt.1_Missense_Mutation_p.P635L|PKP4_uc002tzu.2_Missense_Mutation_p.P783L|PKP4_uc002tzw.2_Missense_Mutation_p.P783L|PKP4_uc002tzx.2_Missense_Mutation_p.P440L|PKP4_uc002tzy.1_Missense_Mutation_p.P441L|PKP4_uc002uaa.2_Missense_Mutation_p.P635L|uc002uab.1_Intron|PKP4_uc002uac.2_5'UTR	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	783					cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						GACTCTGAGCCAAGTTGCTGG	0.448			NA								HNSCC(62;0.18)			27	34					0	0	0.002445	0	0
FAP	2191	broad.mit.edu	37	2	163039931	163039931	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:163039931C>A	uc002ucd.2	-	21	2070	c.1862G>T	c.(1861-1863)TGG>TTG	p.W621L	FAP_uc010fpc.2_Missense_Mutation_p.W170L|FAP_uc010zct.1_Missense_Mutation_p.W596L|FAP_uc010fpd.2_Missense_Mutation_p.W100L	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	621	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						CACCCAGCCCCATATGGCTAT	0.294			NA											51	56					9.77497e-20	1.6544e-19	0.00361	1	0
SCN3A	6328	broad.mit.edu	37	2	165956881	165956881	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:165956881G>T	uc002ucx.2	-	22	4389	c.3897C>A	c.(3895-3897)GCC>GCA	p.A1299A	SCN3A_uc002ucy.2_Silent_p.A1250A|SCN3A_uc002ucz.2_Silent_p.A1250A|SCN3A_uc002uda.1_Silent_p.A1119A|SCN3A_uc002udb.1_Silent_p.A1119A	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1299	Helical; Voltage-sensor; Name=S4 of repeat III; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	ATGATTTGATGGCACCGAGTT	0.383			NA											18	83					8.00594e-06	9.31013e-06	0.007413	1	0
XIRP2	129446	broad.mit.edu	37	2	168105807	168105807	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:168105807A>C	uc002udx.2	+	8	7923	c.7905A>C	c.(7903-7905)GAA>GAC	p.E2635D	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E2460D|XIRP2_uc010fpq.2_Missense_Mutation_p.E2413D|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2460					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CATCGCCAGAAACAGTCGCTG	0.443			NA											22	65					0	0	0.00278	0	0
G6PC2	57818	broad.mit.edu	37	2	169764389	169764389	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:169764389C>T	uc002uem.2	+	5	960	c.868C>T	c.(868-870)CTG>TTG	p.L290L	G6PC2_uc002uen.2_3'UTR|G6PC2_uc010fpv.2_Silent_p.L174L	NM_021176	NP_066999	Q9NQR9	G6PC2_HUMAN	islet-specific glucose-6-phosphatase-related	290	Cytoplasmic (Potential).				gluconeogenesis|glucose homeostasis|glucose transport|regulation of insulin secretion|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			pancreas(1)	1						TAACTACACACTGAGCTTCCG	0.498			NA											15	94					0	0	0.00245	0	0
ABCB11	8647	broad.mit.edu	37	2	169780256	169780256	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:169780256T>C	uc002ueo.1	-	28	3968	c.3842A>G	c.(3841-3843)CAG>CGG	p.Q1281R	ABCB11_uc010zda.1_Missense_Mutation_p.Q699R|ABCB11_uc010zdb.1_Missense_Mutation_p.Q757R	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	1281	Cytoplasmic (Potential).|ABC transporter 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	ATCCGCGTTCTGGATGGTGGA	0.512			NA											22	48					0	0	0.001882	0	0
ABCB11	8647	broad.mit.edu	37	2	169824975	169824975	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:169824975C>T	uc002ueo.1	-	17	2163	c.2037G>A	c.(2035-2037)GCG>GCA	p.A679A	ABCB11_uc010zda.1_Silent_p.A121A|ABCB11_uc010zdb.1_Silent_p.A155A	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	679	Cytoplasmic (Potential).				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	TAAAGGTCCTCGCAAGCATGT	0.398			NA											11	10					0	0	0.001368	0	0
LRP2	4036	broad.mit.edu	37	2	170063588	170063588	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:170063588C>A	uc002ues.2	-	39	6855	c.6642G>T	c.(6640-6642)AAG>AAT	p.K2214N		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2214	LDL-receptor class B 22.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AACGCTCAATCTTTGGTCTCT	0.502			NA											66	140					3.13296e-38	5.95222e-38	0.00361	1	0
PDE11A	50940	broad.mit.edu	37	2	178769854	178769854	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:178769854C>G	uc002ulq.2	-	3	1450	c.1132G>C	c.(1132-1134)GCC>CCC	p.A378P	PDE11A_uc002ulr.2_Missense_Mutation_p.A128P|PDE11A_uc002uls.1_Missense_Mutation_p.A20P|PDE11A_uc002ult.1_Missense_Mutation_p.A128P|PDE11A_uc002ulu.1_Missense_Mutation_p.A20P	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	378					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TTCCTTGAGGCAGCAAAGAGC	0.363			NA							Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				17	52					0	0	0.007413	0	0
TTN	7273	broad.mit.edu	37	2	179408970	179408970	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:179408970A>G	uc010zfg.1	-	294	88506	c.88282T>C	c.(88282-88284)TAC>CAC	p.Y29428H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.Y23123H|TTN_uc010zfi.1_Missense_Mutation_p.Y23056H|TTN_uc010zfj.1_Missense_Mutation_p.Y22931H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30355							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATTCGCTGTATTCGCTCATA	0.403			NA											13	57					0	0	0.001368	0	0
TTN	7273	broad.mit.edu	37	2	179434111	179434111	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:179434111A>G	uc010zfg.1	-	275	69268	c.69044T>C	c.(69043-69045)TTA>TCA	p.L23015S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.L16710S|TTN_uc010zfi.1_Missense_Mutation_p.L16643S|TTN_uc010zfj.1_Missense_Mutation_p.L16518S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23942							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGTTTTCTAATGTAAGCGT	0.413			NA											32	110					0	0	0.008361	0	0
TTN	7273	broad.mit.edu	37	2	179440483	179440483	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:179440483G>T	uc010zfg.1	-	275	62896	c.62672C>A	c.(62671-62673)CCT>CAT	p.P20891H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P14586H|TTN_uc010zfi.1_Missense_Mutation_p.P14519H|TTN_uc010zfj.1_Missense_Mutation_p.P14394H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21818							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTATCAGAGGGAGGTCCCA	0.507			NA											50	60					5.82388e-19	9.76516e-19	0.00361	1	0
TTN	7273	broad.mit.edu	37	2	179442720	179442720	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:179442720G>T	uc010zfg.1	-	271	61042	c.60818C>A	c.(60817-60819)CCA>CAA	p.P20273Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P13968Q|TTN_uc010zfi.1_Missense_Mutation_p.P13901Q|TTN_uc010zfj.1_Missense_Mutation_p.P13776Q|uc002umv.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21200							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTACCAATTGGGTCCAGTGC	0.398			NA											26	52					9.57634e-11	1.30768e-10	0.00333	1	0
TTN	7273	broad.mit.edu	37	2	179463902	179463902	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:179463902C>A	uc010zfg.1	-	239	49138	c.48914G>T	c.(48913-48915)AGT>ATT	p.S16305I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S10000I|TTN_uc010zfi.1_Missense_Mutation_p.S9933I|TTN_uc010zfj.1_Missense_Mutation_p.S9808I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17232							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCAGGTTCACTGTCAAGAGG	0.358			NA											111	215					7.90946e-78	1.53712e-77	0.00361	1	0
TTN	7273	broad.mit.edu	37	2	179474015	179474015	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:179474015C>A	uc010zfg.1	-	222	44542	c.44318G>T	c.(44317-44319)CGA>CTA	p.R14773L	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R8468L|TTN_uc010zfi.1_Missense_Mutation_p.R8401L|TTN_uc010zfj.1_Missense_Mutation_p.R8276L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15700							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGGTCAGGTCGGAGAGAATC	0.438			NA											21	22					8.34094e-07	1.00314e-06	0.008871	1	0
TTN	7273	broad.mit.edu	37	2	179497646	179497646	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:179497646T>A	uc010zfg.1	-	183	35732	c.35508A>T	c.(35506-35508)AAA>AAT	p.K11836N	TTN_uc010zfh.1_Missense_Mutation_p.K5531N|TTN_uc010zfi.1_Missense_Mutation_p.K5464N|TTN_uc010zfj.1_Missense_Mutation_p.K5339N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12763							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAGCATACCTTTCACTTTCA	0.438			NA											99	81					0	0	0.00361	0	0
TTN	7273	broad.mit.edu	37	2	179529239	179529239	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:179529239G>T	uc010zfk.1	-	13	1214	c.666C>A	c.(664-666)GTC>GTA	p.V222V	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	11432							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTTTCCGGGACAACTTCTC	0.393			NA											33	97					6.50621e-10	8.639e-10	0.002836	1	0
TTN	7273	broad.mit.edu	37	2	179599228	179599228	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:179599228C>A	uc010zfg.1	-	49	11815	c.11591G>T	c.(11590-11592)TGG>TTG	p.W3864L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.W525L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4791							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCTTTGAACCAGCTAATTTC	0.383			NA											51	80					8.00217e-19	1.3402e-18	0.00361	1	0
CERKL	375298	broad.mit.edu	37	2	182403888	182403888	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:182403888G>T	uc002unx.2	-	13	1648	c.1547C>A	c.(1546-1548)GCT>GAT	p.A516D	CERKL_uc002uny.2_Missense_Mutation_p.A490D|CERKL_uc010zfm.1_Missense_Mutation_p.A472D|CERKL_uc002unz.2_Missense_Mutation_p.A238D|CERKL_uc002uoa.2_Missense_Mutation_p.A421D|CERKL_uc002uob.2_Missense_Mutation_p.A238D|CERKL_uc002uoc.2_Missense_Mutation_p.A377D|CERKL_uc010frk.2_RNA|CERKL_uc002unw.2_Missense_Mutation_p.A86D	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	516					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			ATTTTCTGAAGCAGTTTCATC	0.373			NA											118	70					1.90269e-63	3.6828e-63	0.00361	1	0
PDE1A	5136	broad.mit.edu	37	2	183011820	183011820	+	Nonsense_Mutation	SNP	C	C	A	rs144375935		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:183011820C>A	uc002uoq.1	-	14	1774	c.1624G>T	c.(1624-1626)GAG>TAG	p.E542*	PDE1A_uc010zfp.1_Nonsense_Mutation_p.E438*|PDE1A_uc010zfq.1_Nonsense_Mutation_p.E542*	NM_005019	NP_005010	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 1	Error:Variant_position_missing_in_P54750_after_alignment					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			GAATGTGTCTCATCATGTTTT	0.259			NA											32	57					6.97489e-18	1.14423e-17	0.004878	1	0
COL3A1	1281	broad.mit.edu	37	2	189859297	189859297	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:189859297G>C	uc002uqj.1	+	19	1441	c.1324G>C	c.(1324-1326)GAG>CAG	p.E442Q		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	442	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TGCCAAAGGAGAGCCCGGACC	0.398			NA											13	55					0	0	0.004007	0	0
COL5A2	1290	broad.mit.edu	37	2	189899839	189899839	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:189899839G>T	uc002uqk.2	-	53	4431	c.4156C>A	c.(4156-4158)CAG>AAG	p.Q1386K	COL5A2_uc010frx.2_Missense_Mutation_p.Q962K	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1386	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			AAAGTCATCTGAGTAATGGCT	0.393			NA											17	64					1.00905e-13	1.51095e-13	0.008871	1	0
COQ10B	80219	broad.mit.edu	37	2	198324753	198324753	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:198324753A>G	uc002uuh.1	+	2	256	c.202A>G	c.(202-204)ACT>GCT	p.T68A	COQ10B_uc010fsl.1_Missense_Mutation_p.T40A	NM_025147	NP_079423	Q9H8M1	CQ10B_HUMAN	coenzyme Q10 homolog B precursor	68						mitochondrial inner membrane					0			Epithelial(96;0.231)|OV - Ovarian serous cystadenocarcinoma(117;0.246)			CTTCAAAATCACTGCACCATT	0.343			NA											9	42					0	0	0.004482	0	0
ZDBF2	57683	broad.mit.edu	37	2	207171539	207171539	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:207171539G>C	uc002vbp.2	+	5	2537	c.2287G>C	c.(2287-2289)GAG>CAG	p.E763Q		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	763							nucleic acid binding|zinc ion binding			ovary(3)	3						GTCAGTTACTGAGCAGTCTCA	0.403			NA											52	123					0	0	0.00361	0	0
ADAM23	8745	broad.mit.edu	37	2	207454155	207454155	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:207454155C>A	uc002vbq.2	+	21	2098	c.1875C>A	c.(1873-1875)TTC>TTA	p.F625L	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	625	Extracellular (Potential).				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		CTGACAAGTTCTGCTATGAAA	0.393	Melanoma(194;1127 2130 19620 24042 27855)		NA											11	22					7.03913e-09	9.16103e-09	0.001368	1	0
C2orf80	389073	broad.mit.edu	37	2	209045976	209045976	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:209045976G>A	uc002vcr.2	-	5	432	c.260C>T	c.(259-261)GCT>GTT	p.A87V		NM_001099334	NP_001092804	Q0P641	CB080_HUMAN	hypothetical protein LOC389073	87										skin(1)	1						TAAAATCATAGCTTCTCGTTC	0.333			NA											15	52					0	0	0.004007	0	0
MAP2	4133	broad.mit.edu	37	2	210558660	210558660	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:210558660G>C	uc002vde.1	+	7	2014	c.1766G>C	c.(1765-1767)GGC>GCC	p.G589A	MAP2_uc002vdc.1_Missense_Mutation_p.G589A|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.G585A	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	589					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	ATTGAGCCAGGCAGTGATTAC	0.388	Pancreas(27;423 979 28787 29963)		NA											23	72					0	0	0.00278	0	0
CPS1	1373	broad.mit.edu	37	2	211464260	211464260	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:211464260G>T	uc002vee.3	+	14	1656	c.1524G>T	c.(1522-1524)ATG>ATT	p.M508I	CPS1_uc010fur.2_Missense_Mutation_p.M514I|CPS1_uc010fus.2_Missense_Mutation_p.M57I	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	508					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TTCTGGGCATGGGTGGCCAGA	0.443			NA											26	54					3.96558e-24	7.13014e-24	0.004656	1	0
CPS1	1373	broad.mit.edu	37	2	211523382	211523382	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:211523382C>A	uc002vee.3	+	31	3858	c.3726C>A	c.(3724-3726)GTC>GTA	p.V1242V	CPS1_uc010fur.2_Silent_p.V1248V|CPS1_uc010fus.2_Silent_p.V791V	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1242	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CATTCAACGTCCAATTTCTTG	0.438			NA											14	45					1.15088e-07	1.43066e-07	0.004007	1	0
ERBB4	2066	broad.mit.edu	37	2	212295716	212295716	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:212295716C>T	uc002veg.1	-	21	2695	c.2597G>A	c.(2596-2598)AGA>AAA	p.R866K	ERBB4_uc002veh.1_Missense_Mutation_p.R866K|ERBB4_uc010zji.1_Missense_Mutation_p.R856K|ERBB4_uc010zjj.1_Missense_Mutation_p.R856K	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	866	Protein kinase.|Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TTCCAAGAGTCTGGCTAGCCC	0.403			NA								TSP Lung(8;0.080)			42	85					0	0	0.002522	0	0
ABCA12	26154	broad.mit.edu	37	2	215876849	215876849	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:215876849G>T	uc002vew.2	-	16	2187	c.1967C>A	c.(1966-1968)CCG>CAG	p.P656Q	ABCA12_uc002vev.2_Missense_Mutation_p.P338Q|ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	656					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		ATCTTTCCTCGGGAAAAACAC	0.274	Ovarian(66;664 1488 5121 34295)		NA											28	86					2.12542e-12	3.0496e-12	0.00632	1	0
STK36	27148	broad.mit.edu	37	2	219544765	219544765	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:219544765G>T	uc002viu.2	+	9	1364	c.1098G>T	c.(1096-1098)TGG>TGT	p.W366C	STK36_uc002viv.2_Missense_Mutation_p.W366C	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	366					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		AGAGCAGCTGGGCTAAATCAG	0.562			NA											20	90					3.83957e-06	4.50868e-06	0.00278	1	0
TMEM198	130612	broad.mit.edu	37	2	220413950	220413950	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:220413950G>T	uc002vme.2	+	5	1404	c.819G>T	c.(817-819)CGG>CGT	p.R273R	TMEM198_uc002vmf.2_Silent_p.R273R|hsa-mir-3132|MI0014152_5'Flank	NM_001005209	NP_001005209	Q66K66	TM198_HUMAN	transmembrane protein 198	273	Arg-rich.					integral to membrane				ovary(1)	1		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		AGAAAAGGCGGAAAAAGAGAC	0.637			NA											19	82					5.35267e-07	6.49709e-07	0.007413	1	0
IRS1	3667	broad.mit.edu	37	2	227662648	227662648	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:227662648C>A	uc002voh.3	-	1	859	c.807G>T	c.(805-807)AAG>AAT	p.K269N		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	269	Ser-rich.				fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		AGGACTGGCTCTTGCTGCGAG	0.637			NA									OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	46					1.99824e-07	2.46911e-07	0.00499	1	0
DNER	92737	broad.mit.edu	37	2	230231801	230231801	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:230231801G>T	uc002vpv.2	-	12	2037	c.1890C>A	c.(1888-1890)AGC>AGA	p.S630R		NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	630	Extracellular (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TGTTGGTGAGGCTCTCCGCCA	0.522			NA											8	20					1.58986e-06	1.8947e-06	0.008291	1	0
SP100	6672	broad.mit.edu	37	2	231406611	231406611	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:231406611G>A	uc002vqu.1	+	28	2549	c.2408G>A	c.(2407-2409)AGA>AAA	p.R803K	SP100_uc010fxp.1_Missense_Mutation_p.R121K	NM_001080391	NP_001073860	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 1	Error:Variant_position_missing_in_P23497_after_alignment					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		CAACAGAACAGAGAGGGGTCT	0.388			NA											11	44					0	0	0.008291	0	0
ECEL1	9427	broad.mit.edu	37	2	233349214	233349214	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:233349214C>A	uc002vsv.2	-	6	1357	c.1152G>T	c.(1150-1152)CAG>CAT	p.Q384H	ECEL1_uc010fya.1_Missense_Mutation_p.Q384H|ECEL1_uc010fyb.1_Missense_Mutation_p.Q91H	NM_004826	NP_004817	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	384	Lumenal (Potential).				neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)	2		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		GCTGCGACACCTGCTGCATGT	0.592			NA											75	84					7.62596e-35	1.43372e-34	0.00361	1	0
GIGYF2	26058	broad.mit.edu	37	2	233626121	233626121	+	Silent	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:233626121T>C	uc002vti.3	+	10	844	c.507T>C	c.(505-507)TTT>TTC	p.F169F	GIGYF2_uc010zmj.1_Silent_p.F169F|GIGYF2_uc002vtg.2_Silent_p.F169F|GIGYF2_uc002vtj.3_Silent_p.F169F|GIGYF2_uc002vtk.3_Silent_p.F169F|GIGYF2_uc002vth.3_Silent_p.F169F|GIGYF2_uc010zmk.1_RNA	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	169	Arg-rich.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		ACAGACGTTTTGAAAAACCAG	0.353			NA											21	34					0	0	0.010504	0	0
NEU2	4759	broad.mit.edu	37	2	233899029	233899029	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:233899029C>A	uc010zmn.1	+	2	405	c.405C>A	c.(403-405)ACC>ACA	p.T135T		NM_005383	NP_005374	Q9Y3R4	NEUR2_HUMAN	neuraminidase 2	135	BNR 1.						exo-alpha-sialidase activity				0		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		ACGGGAGGACCTGGAGCTCCC	0.637			NA											9	32					3.86212e-05	4.37828e-05	0.008291	1	0
UGT1A7	54577	broad.mit.edu	37	2	234591295	234591295	+	Missense_Mutation	SNP	C	C	T	rs141296723	byFrequency	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:234591295C>T	uc002vut.2	+	1	712	c.712C>T	c.(712-714)CCT>TCT	p.P238S	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Missense_Mutation_p.P238S	NM_019077	NP_061950	Q9HAW7	UD17_HUMAN	UDP glycosyltransferase 1 family, polypeptide A7	238					drug metabolic process|negative regulation of fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	drug binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;8.93e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000412)|Lung(119;0.00333)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TCTCCAAACCCCTGTCACGGC	0.413			NA											67	249					0	0	0.00361	0	0
TRAF3IP1	26146	broad.mit.edu	37	2	239307493	239307493	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:239307493A>T	uc002vye.2	+	17	2128	c.2009A>T	c.(2008-2010)AAC>ATC	p.N670I	TRAF3IP1_uc002vyf.2_Missense_Mutation_p.N604I	NM_015650	NP_056465	Q8TDR0	MIPT3_HUMAN	TNF receptor-associated factor 3 interacting	670	DISC1-interaction domain.					cytoplasm|cytoskeleton	protein binding			ovary(1)	1		all_epithelial(40;3.22e-10)|Breast(86;0.000523)|Renal(207;0.00571)|Ovarian(221;0.156)|all_hematologic(139;0.182)		Epithelial(121;9.92e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.85e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.01e-07)|BRCA - Breast invasive adenocarcinoma(100;7.72e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0184)		GTGAAGGCCAACATCCTCAAG	0.448			NA											41	47					0	0	0.006999	0	0
C2orf85	285093	broad.mit.edu	37	2	242815135	242815135	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:242815135C>G	uc010fzu.1	+	2	1451	c.1428C>G	c.(1426-1428)TTC>TTG	p.F476L		NM_173821	NP_776182	Q14D33	CB085_HUMAN	hypothetical protein LOC285093	476						integral to membrane				ovary(1)	1						CCATCCCCTTCGCAGTCTTCG	0.627			NA											21	69					0	0	0.010504	0	0
DEFB126	81623	broad.mit.edu	37	20	126203	126203	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:126203C>A	uc002wcx.2	+	2	224	c.206C>A	c.(205-207)CCT>CAT	p.P69H		NM_030931	NP_112193	Q9BYW3	DB126_HUMAN	defensin, beta 126 preproprotein	69					defense response to bacterium	extracellular region					0		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			GCTAATTATCCTGTTTTCTGT	0.363			NA											19	32					6.49762e-13	9.4072e-13	0.006122	1	0
TGM6	343641	broad.mit.edu	37	20	2375157	2375157	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:2375157C>A	uc002wfy.1	+	2	128	c.67C>A	c.(67-69)CAG>AAG	p.Q23K	TGM6_uc010gal.1_Missense_Mutation_p.Q23K	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	23					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	CCACCACACCCAGGAGTACCC	0.642			NA											8	16					0.000274275	0.000300993	0.004482	1	0
TGM6	343641	broad.mit.edu	37	20	2375918	2375918	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:2375918C>G	uc002wfy.1	+	3	321	c.260C>G	c.(259-261)GCA>GGA	p.A87G	TGM6_uc010gal.1_Missense_Mutation_p.A87G	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	87					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	GGCTGGACAGCAGCAAGGGAG	0.612			NA											4	16					0	0	0.009096	0	0
DDRGK1	65992	broad.mit.edu	37	20	3183950	3183950	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:3183950C>A	uc002wic.2	-	2	226	c.204G>T	c.(202-204)AGG>AGT	p.R68S	DDRGK1_uc010gaw.2_RNA|DDRGK1_uc010gax.1_Missense_Mutation_p.R68S	NM_023935	NP_076424	Q96HY6	DDRGK_HUMAN	DDRGK domain containing 1 precursor	68						endoplasmic reticulum	protein binding				0						TGCCCAGGTCCCTCCGGCGCC	0.697			NA											5	4					0.000602214	0.000654897	0.000602	1	0
C20orf29	55317	broad.mit.edu	37	20	3804570	3804570	+	Missense_Mutation	SNP	A	A	G	rs149938656		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:3804570A>G	uc002wjs.1	+	3	407	c.229A>G	c.(229-231)ATG>GTG	p.M77V	C20orf29_uc002wjt.2_Missense_Mutation_p.M1V|C20orf29_uc002wju.1_Missense_Mutation_p.M77V	NM_018347	NP_060817	Q9NUS5	CT029_HUMAN	hypothetical protein LOC55317	77					double-strand break repair via homologous recombination		protein binding			skin(1)	1						CCGGCCCCCCATGGACCTGCA	0.612			NA											11	25					0	0	0.001855	0	0
TRMT6	51605	broad.mit.edu	37	20	5922665	5922665	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:5922665C>A	uc002wmh.1	-	8	1166	c.1044G>T	c.(1042-1044)AGG>AGT	p.R348S	TRMT6_uc010zra.1_Missense_Mutation_p.R178S|TRMT6_uc010gbn.1_3'UTR	NM_015939	NP_057023	Q9UJA5	TRM6_HUMAN	tRNA methyltransferase 6	348					regulation of translational initiation|tRNA processing	nucleus	protein binding|translation initiation factor activity			pancreas(1)	1						CTTCTTGTCTCCTCTGTTTTT	0.428			NA											39	68					1.465e-08	1.89126e-08	0.00874	1	0
FERMT1	55612	broad.mit.edu	37	20	6065747	6065747	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:6065747G>A	uc002wmr.2	-	12	2348	c.1559C>T	c.(1558-1560)TCA>TTA	p.S520L	FERMT1_uc002wmq.2_Missense_Mutation_p.S73L|FERMT1_uc010gbt.2_Missense_Mutation_p.S263L	NM_017671	NP_060141	Q9BQL6	FERM1_HUMAN	kindlin-1	520	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			ovary(1)|pancreas(1)|skin(1)	3						ACACCGTGGTGACACAAAACA	0.393			NA											31	57					0	0	0.002445	0	0
PLCB1	23236	broad.mit.edu	37	20	8665694	8665694	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:8665694C>G	uc002wnb.2	+	10	981	c.978C>G	c.(976-978)TTC>TTG	p.F326L	PLCB1_uc010zrb.1_Missense_Mutation_p.F225L|PLCB1_uc002wna.2_Missense_Mutation_p.F326L|PLCB1_uc002wnc.1_Missense_Mutation_p.F225L	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	326	PI-PLC X-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CTCACTATTTCATTAATTCCT	0.413			NA											50	95					0	0	0.00361	0	0
PLCB4	5332	broad.mit.edu	37	20	9402085	9402085	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:9402085G>T	uc002wnf.2	+	25	2396	c.2260G>T	c.(2260-2262)GAA>TAA	p.E754*	PLCB4_uc010gbw.1_Nonsense_Mutation_p.E754*|PLCB4_uc010gbx.2_Nonsense_Mutation_p.E766*|PLCB4_uc002wne.2_Nonsense_Mutation_p.E754*|PLCB4_uc002wnh.2_Nonsense_Mutation_p.E601*	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	754	C2.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						AGTTTACAATGAAGAGTCATT	0.418			NA											17	33					1.01871e-10	1.38714e-10	0.008871	1	0
RRBP1	6238	broad.mit.edu	37	20	17600359	17600359	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:17600359C>T	uc002wpv.1	-	20	2649	c.2295G>A	c.(2293-2295)ACG>ACA	p.T765T	RRBP1_uc010zrp.1_5'UTR|RRBP1_uc002wpt.1_Silent_p.T135T|RRBP1_uc002wpu.2_Silent_p.T539T|RRBP1_uc002wpw.1_Silent_p.T765T|RRBP1_uc010gcl.1_Silent_p.T539T	NM_001042576	NP_001036041	Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	1198	Cytoplasmic (Potential).				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1						CCAAATGCGACGTGTGCTCCC	0.652			NA											10	25					0	0	0.008291	0	0
CST2	1470	broad.mit.edu	37	20	23804722	23804722	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:23804722G>T	uc002wtq.1	-	3	376	c.361C>A	c.(361-363)CAG>AAG	p.Q121K		NM_001322	NP_001313	P09228	CYTT_HUMAN	cystatin SA precursor	121						extracellular region	cysteine-type endopeptidase inhibitor activity				0						TCGTAGATCTGGAAAGAGCAC	0.517	Pancreas(193;496 3017 22514 29918)		NA											17	29					1.67942e-08	2.14882e-08	0.006122	1	0
NINL	22981	broad.mit.edu	37	20	25457663	25457663	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:25457663C>T	uc002wux.1	-	17	2338	c.2264G>A	c.(2263-2265)AGA>AAA	p.R755K	NINL_uc010gdn.1_Intron	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	755					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GGTCAGGTCTCTGCGAGCGGG	0.682			NA											6	15					0	0	0.001984	0	0
EDEM2	55741	broad.mit.edu	37	20	33722565	33722565	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:33722565C>A	uc002xbo.2	-	6	778	c.678G>T	c.(676-678)TGG>TGT	p.W226C	EDEM2_uc010zuv.1_Missense_Mutation_p.W185C|EDEM2_uc010zus.1_5'UTR|EDEM2_uc002xbq.2_Missense_Mutation_p.W189C|EDEM2_uc010zut.1_Missense_Mutation_p.W185C|EDEM2_uc002xbp.2_Missense_Mutation_p.W74C|EDEM2_uc002xbn.2_Missense_Mutation_p.W74C|EDEM2_uc002xbr.2_RNA|EDEM2_uc010zuu.1_Intron	NM_018217	NP_060687	Q9BV94	EDEM2_HUMAN	ER degradation enhancer, mannosidase alpha-like	226					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00936)			ACCGGCTCTCCCAGAGGCGCA	0.567	Esophageal Squamous(51;906 1021 24535 36410 39145)		NA											29	20					9.04072e-19	1.51238e-18	0.003271	1	0
C20orf4	25980	broad.mit.edu	37	20	34827870	34827870	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:34827870C>A	uc002xfc.1	+	2	173	c.80C>A	c.(79-81)CCC>CAC	p.P27H	C20orf4_uc002xfd.1_Missense_Mutation_p.P27H|C20orf4_uc002xfe.1_Missense_Mutation_p.P27H	NM_015511	NP_056326	Q9Y312	CT004_HUMAN	hypothetical protein LOC25980	27											0	Breast(12;0.0162)	Myeloproliferative disorder(115;0.0393)				CTGAACATGCCCAAGGGAACA	0.582			NA											40	40					3.05275e-18	5.03668e-18	0.003214	1	0
KIAA1755	85449	broad.mit.edu	37	20	36841559	36841559	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:36841559G>T	uc002xhy.1	-	14	3760	c.3488C>A	c.(3487-3489)CCC>CAC	p.P1163H	KIAA1755_uc002xhv.1_Missense_Mutation_p.P227H|KIAA1755_uc002xhw.1_Missense_Mutation_p.P218H|KIAA1755_uc002xhx.1_Missense_Mutation_p.P441H	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	1163										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				CTGCCTGGGGGGCTGCTGCCG	0.647			NA											37	34					8.16277e-20	1.3897e-19	0.006999	1	0
PTPRT	11122	broad.mit.edu	37	20	40710553	40710553	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:40710553C>T	uc002xkg.2	-	30	4425	c.4241G>A	c.(4240-4242)CGT>CAT	p.R1414H	PTPRT_uc010ggj.2_Missense_Mutation_p.R1433H|PTPRT_uc010ggi.2_Missense_Mutation_p.R617H	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1414	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TTTGTTGTTACGCAGTGTTTT	0.507			NA											38	59					0	0	0.007835	0	0
TOX2	84969	broad.mit.edu	37	20	42679966	42679966	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:42679966G>T	uc002xlf.3	+	4	476	c.459G>T	c.(457-459)TCG>TCT	p.S153S	TOX2_uc010ggo.2_Silent_p.S144S|TOX2_uc002xle.3_Silent_p.S102S|TOX2_uc010ggp.2_Silent_p.S102S|TOX2_uc002xlg.2_Silent_p.S102S|TOX2_uc010zwk.1_Silent_p.S22S	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	153					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			TGGTCCACTCGGAAGTGGCTG	0.612			NA											44	14					4.67007e-22	8.16271e-22	0.00874	1	0
TOX2	84969	broad.mit.edu	37	20	42680075	42680075	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:42680075G>T	uc002xlf.3	+	4	585	c.568G>T	c.(568-570)GGC>TGC	p.G190C	TOX2_uc010ggo.2_Missense_Mutation_p.G181C|TOX2_uc002xle.3_Missense_Mutation_p.G139C|TOX2_uc010ggp.2_Missense_Mutation_p.G139C|TOX2_uc002xlg.2_Missense_Mutation_p.G139C|TOX2_uc010zwk.1_Missense_Mutation_p.G59C	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CTCGCAGATGGGCATCCGGAG	0.677			NA											4	24					1.024e-07	1.28401e-07	0.000602	1	0
HNF4A	3172	broad.mit.edu	37	20	43058302	43058302	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:43058302C>A	uc002xma.2	+	10	1511	c.1422C>A	c.(1420-1422)ATC>ATA	p.I474I	HNF4A_uc002xlu.2_Silent_p.I442I|HNF4A_uc002xlv.2_Silent_p.I452I|HNF4A_uc002xlz.2_Silent_p.I464I|HNF4A_uc010ggq.2_Silent_p.I467I	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	474					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			AGGAAGTTATCTAGCAAGCCG	0.627	Colon(79;2 1269 8820 14841 52347)		NA											25	109					2.41591e-17	3.8968e-17	0.004656	1	0
WFDC5	149708	broad.mit.edu	37	20	43739107	43739107	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:43739107C>A	uc002xne.1	-	3	380	c.301G>T	c.(301-303)GAC>TAC	p.D101Y		NM_145652	NP_663627	Q8TCV5	WFDC5_HUMAN	WAP four-disulfide core domain 5 precursor	101	WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CCCGAGCAGTCTGAGTCCTTG	0.647	NSCLC(199;98 2227 9943 13455 41914)		NA											4	13					0.00024832	0.00027355	0.009096	1	0
CTSA	5476	broad.mit.edu	37	20	44527062	44527062	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:44527062C>T	uc002xqj.3	+	15	1890	c.1416C>T	c.(1414-1416)TCC>TCT	p.S472S	CTSA_uc002xqh.2_Silent_p.S490S|CTSA_uc002xqi.2_RNA|CTSA_uc010zxi.1_Silent_p.S473S|CTSA_uc002xqk.3_Silent_p.S472S	NM_001127695	NP_001121167	P10619	PPGB_HUMAN	cathepsin A isoform b precursor	472					intracellular protein transport|proteolysis	endoplasmic reticulum|lysosome|nucleus	enzyme activator activity|protein binding|serine-type carboxypeptidase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CCATGTTCTCCCGCTTCCTGA	0.612			NA											4	33					0	0	0.000602	0	0
ZNF335	63925	broad.mit.edu	37	20	44578493	44578493	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:44578493C>G	uc002xqw.2	-	24	3738	c.3615G>C	c.(3613-3615)GAG>GAC	p.E1205D	ZNF335_uc002xqv.2_Missense_Mutation_p.E317D|ZNF335_uc010zxk.1_Missense_Mutation_p.E1050D	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	1205	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				CCGTGGTGATCTCTTGGATGT	0.597			NA											37	38					0	0	0.005524	0	0
SLC13A3	64849	broad.mit.edu	37	20	45224895	45224895	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:45224895T>A	uc002xsf.1	-	5	733	c.695A>T	c.(694-696)AAG>ATG	p.K232M	SLC13A3_uc010ghn.1_Missense_Mutation_p.K201M|SLC13A3_uc010zxw.1_Missense_Mutation_p.R210W|SLC13A3_uc002xsg.1_Missense_Mutation_p.K185M|SLC13A3_uc010gho.1_Missense_Mutation_p.K185M|SLC13A3_uc010zxx.1_Missense_Mutation_p.K134M	NM_022829	NP_073740	Q8WWT9	S13A3_HUMAN	solute carrier family 13 member 3 isoform a	232	Helical; (Potential).					integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	GAGGAAGCCCTTCCAGATGTT	0.562			NA											18	90					0	0	0.007413	0	0
EYA2	2139	broad.mit.edu	37	20	45717947	45717947	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:45717947C>A	uc002xsm.2	+	8	1105	c.731C>A	c.(730-732)GCC>GAC	p.A244D	EYA2_uc010ghp.2_Missense_Mutation_p.A244D|EYA2_uc002xsn.2_Missense_Mutation_p.A249D|EYA2_uc002xso.2_Missense_Mutation_p.A244D|EYA2_uc002xsp.2_Missense_Mutation_p.A244D|EYA2_uc002xsq.2_Missense_Mutation_p.A244D	NM_005244	NP_005235	O00167	EYA2_HUMAN	eyes absent 2 isoform a	244					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0241)				CCGCACCGGGCCTCCGACGGG	0.577	Pancreas(120;56 1725 18501 25218 43520)		NA											40	66					9.85913e-13	1.42596e-12	0.009718	1	0
KCNB1	3745	broad.mit.edu	37	20	47989796	47989796	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:47989796G>T	uc002xur.1	-	2	2465	c.2301C>A	c.(2299-2301)CTC>CTA	p.L767L	KCNB1_uc002xus.1_Silent_p.L767L	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	767	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CCACACTGTAGAGCAGCTGTC	0.562			NA											202	227					2.24254e-89	4.36993e-89	0.00361	1	0
PTGIS	5740	broad.mit.edu	37	20	48129705	48129705	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:48129705C>T	uc002xut.2	-	8	1172	c.1118G>A	c.(1117-1119)CGA>CAA	p.R373Q	PTGIS_uc010zyi.1_Missense_Mutation_p.R234Q	NM_000961	NP_000952	Q16647	PTGIS_HUMAN	prostaglandin I2 synthase	373					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	GTTGAATTCTCGCCCGTCTGC	0.602			NA											33	92					0	0	0.003271	0	0
SPATA2	9825	broad.mit.edu	37	20	48522819	48522819	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:48522819G>A	uc010gie.2	-	3	1250	c.900C>T	c.(898-900)ACC>ACT	p.T300T	SPATA2_uc002xuw.2_Silent_p.T300T|SPATA2_uc010zyn.1_Silent_p.T163T	NM_001135773	NP_001129245	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	300					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			AGCTGGCCATGGTCAGCAGCG	0.652			NA											52	61					0	0	0.00361	0	0
FAM65C	140876	broad.mit.edu	37	20	49208924	49208924	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:49208924G>A	uc002xvm.2	-	19	2840	c.2522C>T	c.(2521-2523)GCT>GTT	p.A841V	FAM65C_uc010zyt.1_Missense_Mutation_p.A845V	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	841										ovary(2)	2						AGCCAGGCGAGCGCTGGCCGC	0.657			NA											25	63					0	0	0.008361	0	0
PARD6B	84612	broad.mit.edu	37	20	49366697	49366697	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:49366697G>T	uc002xvo.2	+	3	1034	c.791G>T	c.(790-792)AGT>ATT	p.S264I		NM_032521	NP_115910	Q9BYG5	PAR6B_HUMAN	PAR-6 beta	264					axonogenesis|cell cycle|cell division|establishment or maintenance of cell polarity|protein complex assembly|regulation of cell migration|tight junction assembly	cytosol|tight junction	protein binding			kidney(1)	1						ACTTCTGGCAGTTCCGGTCAG	0.463			NA											63	120					1.7104e-27	3.14993e-27	0.00361	1	0
SALL4	57167	broad.mit.edu	37	20	50407075	50407075	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:50407075C>A	uc002xwh.3	-	2	2048	c.1947G>T	c.(1945-1947)ATG>ATT	p.M649I	SALL4_uc010gii.2_Intron|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	649					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TCTGACCGCCCATGTGCATCC	0.547			NA											37	39					7.04047e-22	1.2291e-21	0.005524	1	0
TSHZ2	128553	broad.mit.edu	37	20	51871229	51871229	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:51871229C>A	uc002xwo.2	+	2	2188	c.1232C>A	c.(1231-1233)TCT>TAT	p.S411Y		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	411					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			GTCACCAGCTCTGCCTCCAAG	0.527			NA											100	123					5.84261e-33	1.09558e-32	0.00361	1	0
ZNF217	7764	broad.mit.edu	37	20	52193540	52193540	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:52193540C>A	uc002xwq.3	-	3	2034	c.1763G>T	c.(1762-1764)GGC>GTC	p.G588V	ZNF217_uc010gij.1_Missense_Mutation_p.G580V	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	588					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			GACAGCGCTGCCCAGAACATT	0.423			NA											26	90					4.72057e-08	5.96588e-08	0.003954	1	0
CTCFL	140690	broad.mit.edu	37	20	56099195	56099195	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:56099195G>A	uc010gix.1	-	1	729	c.67C>T	c.(67-69)CCG>TCG	p.P23S	CTCFL_uc010giw.1_Missense_Mutation_p.P23S|CTCFL_uc002xym.2_Missense_Mutation_p.P23S|CTCFL_uc010giz.1_Intron|CTCFL_uc010giy.1_Intron|CTCFL_uc010gja.1_Missense_Mutation_p.P23S|CTCFL_uc010gjb.1_Missense_Mutation_p.P23S|CTCFL_uc010gjc.1_Missense_Mutation_p.P23S|CTCFL_uc010gjd.1_Missense_Mutation_p.P23S|CTCFL_uc010gje.2_Missense_Mutation_p.P23S|CTCFL_uc010gjf.2_Intron|CTCFL_uc010gjg.2_Intron|CTCFL_uc010gjh.1_Missense_Mutation_p.P23S|CTCFL_uc010gji.1_Intron|CTCFL_uc010gjj.1_Missense_Mutation_p.P23S|CTCFL_uc010gjk.1_Missense_Mutation_p.P23S|CTCFL_uc010gjl.1_Missense_Mutation_p.P23S	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	23					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CCTTTTTCCGGCATCAACTCG	0.507			NA											203	241					0	0	0.00361	0	0
ZBP1	81030	broad.mit.edu	37	20	56186853	56186853	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:56186853G>T	uc002xyo.2	-	6	1085	c.804C>A	c.(802-804)CAC>CAA	p.H268Q	ZBP1_uc010gjm.2_Missense_Mutation_p.H267Q|ZBP1_uc002xyp.2_Missense_Mutation_p.H193Q	NM_030776	NP_110403	Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1 isoform a	268	RIP homotypic interaction motif (RHIM) 2.					cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			ovary(2)	2	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			TCTCATTGCTGTGTCCCAGCT	0.632			NA											8	11					3.03607e-14	4.59393e-14	0.001368	1	0
GNAS	2778	broad.mit.edu	37	20	57429950	57429950	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:57429950C>T	uc002xzw.2	+	1	1915	c.1630C>T	c.(1630-1632)CGG>TGG	p.R544W	GNAS_uc002xzt.2_Intron|GNAS_uc002xzu.3_Intron|GNAS_uc010gjq.2_Intron|GNAS_uc002xzv.2_RNA	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GCCTACTCCGCGGCCTACTCG	0.716	Colon(117;935 1597 6045 8307 46442)		NA	Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			6	6					0	0	0.001168	0	0
ZNF831	128611	broad.mit.edu	37	20	57767204	57767204	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:57767204G>A	uc002yan.2	+	1	1130	c.1130G>A	c.(1129-1131)GGC>GAC	p.G377D		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	377						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GAGGGGGAgggcggcccgggc	0.527			NA											5	20					0	0	0.000602	0	0
ZNF831	128611	broad.mit.edu	37	20	57768774	57768774	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:57768774G>C	uc002yan.2	+	1	2700	c.2700G>C	c.(2698-2700)AGG>AGC	p.R900S		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	900						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TGGGGCCAAGGGACAAGGCTA	0.672			NA											20	35					0	0	0.010504	0	0
ZNF831	128611	broad.mit.edu	37	20	57769036	57769036	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:57769036C>G	uc002yan.2	+	1	2962	c.2962C>G	c.(2962-2964)CTT>GTT	p.L988V		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	988						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GGGGACCCCTCTTTCTCCCAG	0.637			NA											20	59					0	0	0.008871	0	0
C20orf177	63939	broad.mit.edu	37	20	58519167	58519167	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:58519167A>G	uc002yba.2	+	5	584	c.169A>G	c.(169-171)AGA>GGA	p.R57G	C20orf177_uc010zzx.1_Intron|C20orf177_uc002ybc.2_Missense_Mutation_p.R57G	NM_022106	NP_071389	Q9NTX9	CT177_HUMAN	hypothetical protein LOC63939	57										ovary(2)|breast(1)	3	all_lung(29;0.00693)		BRCA - Breast invasive adenocarcinoma(7;1.22e-08)			CCCGGAAGCAAGACGCAAAAG	0.468			NA											27	62					0	0	0.007291	0	0
CDH4	1002	broad.mit.edu	37	20	60448826	60448826	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:60448826G>T	uc002ybn.1	+	7	934	c.920G>T	c.(919-921)AGC>ATC	p.S307I	CDH4_uc002ybp.1_Missense_Mutation_p.S233I	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	307	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GCTGACGACAGCACCACGGCC	0.617			NA											52	82					5.39261e-20	9.21344e-20	0.00361	1	0
COL20A1	57642	broad.mit.edu	37	20	61937328	61937328	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:61937328G>T	uc011aau.1	+	5	533	c.433G>T	c.(433-435)GAC>TAC	p.D145Y	COL20A1_uc011aav.1_5'Flank	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	145					cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					GGGGAGCCCAGACCCTGAGCA	0.647			NA											25	30					3.6726e-16	5.81327e-16	0.003954	1	0
COL20A1	57642	broad.mit.edu	37	20	61939938	61939938	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:61939938G>T	uc011aau.1	+	8	920	c.820G>T	c.(820-822)GCT>TCT	p.A274S	COL20A1_uc011aav.1_Missense_Mutation_p.A95S	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	274	VWFA.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					GCAGCCGGCGGCTGGCCTCCG	0.647			NA											5	13					0.00116845	0.00125927	0.001168	1	0
COL20A1	57642	broad.mit.edu	37	20	61945437	61945437	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:61945437G>T	uc011aau.1	+	19	2472	c.2372G>T	c.(2371-2373)GGA>GTA	p.G791V	COL20A1_uc011aav.1_Missense_Mutation_p.G612V	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	791	Fibronectin type-III 6.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					TCTGTGCCAGGAGCCAGGAGC	0.637			NA											14	16					4.14922e-12	5.89475e-12	0.004007	1	0
COL20A1	57642	broad.mit.edu	37	20	61945462	61945462	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:61945462C>A	uc011aau.1	+	19	2497	c.2397C>A	c.(2395-2397)CCC>CCA	p.P799P	COL20A1_uc011aav.1_Silent_p.P620P	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	799	Fibronectin type-III 6.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					TGACACTGCCCGACCTGCAGG	0.637			NA											6	16					0.00116845	0.00125927	0.001168	1	0
GRIK1	2897	broad.mit.edu	37	21	30959887	30959887	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr21:30959887G>A	uc002yno.1	-	12	2056	c.1592C>T	c.(1591-1593)CCT>CTT	p.P531L	GRIK1_uc002ynn.2_Missense_Mutation_p.P516L|GRIK1_uc011acs.1_Missense_Mutation_p.P531L|GRIK1_uc011act.1_Missense_Mutation_p.P392L|GRIK1_uc010glq.1_Missense_Mutation_p.P374L	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	531	Glutamate binding (By similarity).|Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GATGGTAAGAGGAGCCACTGC	0.478			NA											13	13					0	0	0.00245	0	0
KRTAP13-1	140258	broad.mit.edu	37	21	31768821	31768821	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr21:31768821C>A	uc002yoa.2	+	1	430	c.417C>A	c.(415-417)TCC>TCA	p.S139S		NM_181599	NP_853630	Q8IUC0	KR131_HUMAN	keratin associated protein 13-1	139						intermediate filament				ovary(1)	1						GCTTCCCTTCCCTGGGCTATG	0.572			NA											6	38					5.9392e-07	7.17882e-07	0.001168	1	0
KRTAP21-2	337978	broad.mit.edu	37	21	32119357	32119357	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr21:32119357G>T	uc011adh.1	-	1	164	c.164C>A	c.(163-165)TCT>TAT	p.S55Y		NM_181617	NP_853648	Q3LI59	KR212_HUMAN	keratin associated protein 21-2	55						intermediate filament					0						tccacagccagagccgtatcc	0.179			NA											15	37					2.35188e-11	3.27673e-11	0.006122	1	0
TIAM1	7074	broad.mit.edu	37	21	32492884	32492884	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr21:32492884C>T	uc002yow.1	-	29	5050	c.4578G>A	c.(4576-4578)GAG>GAA	p.E1526E	TIAM1_uc011adk.1_3'UTR|TIAM1_uc011adl.1_Silent_p.E1466E	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1526					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						CCTGAAGCCGCTCCTGCAGGT	0.567			NA											16	32					0	0	0.00499	0	0
MRPS6	64968	broad.mit.edu	37	21	35514757	35514757	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr21:35514757G>T	uc002ytp.2	+	3	413	c.235G>T	c.(235-237)GTG>TTG	p.V79L		NM_032476	NP_115865	P82932	RT06_HUMAN	mitochondrial ribosomal protein S6	79					translation	mitochondrion|small ribosomal subunit	rRNA binding|structural constituent of ribosome			skin(1)	1						TGAAAGCATGGTGGAGCACTT	0.408			NA											25	40					6.07407e-21	1.04896e-20	0.007291	1	0
SIM2	6493	broad.mit.edu	37	21	38092173	38092173	+	Missense_Mutation	SNP	G	G	A	rs149282278	byFrequency	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr21:38092173G>A	uc002yvr.2	+	4	456	c.400G>A	c.(400-402)GAT>AAT	p.D134N	SIM2_uc002yvq.2_Missense_Mutation_p.D134N	NM_005069	NP_005060	Q14190	SIM2_HUMAN	single-minded homolog 2 long isoform	134	PAS 1.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(1)	1						TTCTGACCACGATGAGATGAC	0.532			NA											18	70					0	0	0.010504	0	0
DSCAM	1826	broad.mit.edu	37	21	41684166	41684166	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr21:41684166C>A	uc002yyq.1	-	9	2356	c.1904G>T	c.(1903-1905)CGG>CTG	p.R635L	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	635	Extracellular (Potential).|Ig-like C2-type 7.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AGGGATTGGCCGGCCATCCTT	0.522	Melanoma(134;970 1778 1785 21664 32388)		NA											7	35					5.18039e-06	6.06341e-06	0.00308	1	0
ZNF295	49854	broad.mit.edu	37	21	43411970	43411970	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr21:43411970C>T	uc002zab.3	-	3	2449	c.2235G>A	c.(2233-2235)CGG>CGA	p.R745R	ZNF295_uc002yzz.3_Silent_p.R544R|ZNF295_uc002yzy.3_Silent_p.R745R|ZNF295_uc002zaa.3_Silent_p.R745R	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	745					negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CGGCCGCGTTCCGGCACAGCC	0.547			NA											57	140					0	0	0.00361	0	0
ZNF295	49854	broad.mit.edu	37	21	43412359	43412359	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr21:43412359C>T	uc002zab.3	-	3	2060	c.1846G>A	c.(1846-1848)GAA>AAA	p.E616K	ZNF295_uc002yzz.3_Intron|ZNF295_uc002yzy.3_Missense_Mutation_p.E616K|ZNF295_uc002zaa.3_Missense_Mutation_p.E616K	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	616					negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						TGGAATTTTTCATCCAAAACA	0.453			NA											20	56					0	0	0.010504	0	0
ZNF295	49854	broad.mit.edu	37	21	43413863	43413863	+	Silent	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr21:43413863C>G	uc002zab.3	-	3	556	c.342G>C	c.(340-342)CTG>CTC	p.L114L	ZNF295_uc002yzz.3_Silent_p.L114L|ZNF295_uc002yzy.3_Silent_p.L114L|ZNF295_uc002zaa.3_Silent_p.L114L|ZNF295_uc010gov.1_Silent_p.L114L|ZNF295_uc002zac.2_Silent_p.L114L	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	114					negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CGATGTTAGTCAGAAAGGAAA	0.368			NA											11	27					0	0	0.001855	0	0
TFF2	7032	broad.mit.edu	37	21	43767673	43767673	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr21:43767673C>T	uc002zaw.2	-	3	440	c.298G>A	c.(298-300)GAA>AAA	p.E100K		NM_005423	NP_005414	Q03403	TFF2_HUMAN	trefoil factor 2 precursor	100	P-type 2.				digestion	extracellular region				pancreas(1)	1						GAGGCGCATTCCTCGGGGCTG	0.582			NA											15	22					0	0	0.003163	0	0
COL6A2	1292	broad.mit.edu	37	21	47532214	47532214	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr21:47532214G>A	uc002zia.1	+	3	519	c.437G>A	c.(436-438)CGG>CAG	p.R146Q	COL6A2_uc002zhy.1_Missense_Mutation_p.R146Q|COL6A2_uc002zhz.1_Missense_Mutation_p.R146Q|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	146	VWFA 1.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		GAGCAGATCCGGCAGGACCGC	0.687			NA											6	17					0	0	0.001168	0	0
LSS	4047	broad.mit.edu	37	21	47636393	47636393	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr21:47636393G>T	uc002zij.2	-	7	772	c.693C>A	c.(691-693)TGC>TGA	p.C231*	LSS_uc011afv.1_Nonsense_Mutation_p.C220*|LSS_uc002zil.2_Nonsense_Mutation_p.C231*|LSS_uc002zik.2_Nonsense_Mutation_p.C151*	NM_001001438	NP_001001438	P48449	ERG7_HUMAN	lanosterol synthase isoform 1	231					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity				0	Breast(49;0.214)					GCCGGCAGTGGCACCAGAGTG	0.662	Pancreas(114;955 2313 34923 50507)		NA											3	16					0.004672	0.00492473	0.004672	1	0
PCNT	5116	broad.mit.edu	37	21	47783821	47783821	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr21:47783821G>T	uc002zji.3	+	14	2688	c.2581G>T	c.(2581-2583)GCC>TCC	p.A861S	PCNT_uc002zjj.2_Missense_Mutation_p.A743S	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	861					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GGAAGACTGCGCCCTGCAGCT	0.657			NA											26	52					7.4402e-23	1.31641e-22	0.003954	1	0
DIP2A	23181	broad.mit.edu	37	21	47918578	47918578	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr21:47918578G>A	uc002zjo.2	+	5	670	c.487G>A	c.(487-489)GTC>ATC	p.V163I	DIP2A_uc011afy.1_Missense_Mutation_p.V99I|DIP2A_uc011afz.1_Missense_Mutation_p.V163I|DIP2A_uc002zjl.2_Missense_Mutation_p.V163I|DIP2A_uc002zjm.2_Missense_Mutation_p.V163I|DIP2A_uc010gql.2_Missense_Mutation_p.V163I|DIP2A_uc002zjn.2_Missense_Mutation_p.V163I	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	163					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CCATTCCAGCGTCGAGCCCTG	0.617			NA											22	81					0	0	0.00278	0	0
POTEH	23784	broad.mit.edu	37	22	16287925	16287925	+	Translation_Start_Site	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr22:16287925G>T	uc010gqp.2	-	1	13	c.-39C>A	c.(-41--37)ATCTG>ATATG		POTEH_uc002zlg.1_5'Flank|POTEH_uc002zlh.1_5'Flank|POTEH_uc002zlj.1_Translation_Start_Site	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3											skin(1)	1						GTAGCCAGCAGATCGCGTCTA	0.532			NA											17	51					2.48551e-13	3.65724e-13	0.00499	1	0
GAB4	128954	broad.mit.edu	37	22	17447120	17447120	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr22:17447120C>A	uc002zlw.2	-	6	1266	c.1158G>T	c.(1156-1158)GTG>GTT	p.V386V	GAB4_uc010gqs.1_3'UTR	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member	386										large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				GACATGAGCCCACAGGGATGC	0.597			NA											11	44					5.50884e-06	6.41659e-06	0.001368	1	0
IL17RA	23765	broad.mit.edu	37	22	17578800	17578800	+	Missense_Mutation	SNP	G	G	A	rs147495146	byFrequency	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr22:17578800G>A	uc002zly.2	+	3	410	c.277G>A	c.(277-279)GTG>ATG	p.V93M	IL17RA_uc010gqt.2_Missense_Mutation_p.V93M	NM_014339	NP_055154	Q96F46	I17RA_HUMAN	interleukin 17A receptor precursor	93	Extracellular (Potential).				fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			skin(2)	2		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		CCTGTTCCCCGTGGCTCACAT	0.612			NA											28	31					0	0	0.008361	0	0
DGCR8	54487	broad.mit.edu	37	22	20093787	20093787	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr22:20093787G>T	uc002zri.2	+	10	2226	c.1876G>T	c.(1876-1878)GAG>TAG	p.E626*	DGCR8_uc010grz.2_Nonsense_Mutation_p.E593*|DGCR8_uc002zrj.2_Nonsense_Mutation_p.E269*	NM_022720	NP_073557	Q8WYQ5	DGCR8_HUMAN	DiGeorge syndrome critical region gene 8	626	DRBM 2.|Necessary for heme-binding and pri-miRNA processing.|Necessary for interaction with DROSHA.				primary miRNA processing	cytoplasm|cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding				0	Colorectal(54;0.0993)					GATCCTCCACGAGTGCCTTAA	0.547			NA											12	42					2.80697e-09	3.68639e-09	0.000978	1	0
MYO18B	84700	broad.mit.edu	37	22	26298650	26298650	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr22:26298650C>T	uc003abz.1	+	30	5144	c.4894C>T	c.(4894-4896)CAG>TAG	p.Q1632*	MYO18B_uc003aca.1_Nonsense_Mutation_p.Q1513*|MYO18B_uc010guy.1_Nonsense_Mutation_p.Q1514*|MYO18B_uc010guz.1_Nonsense_Mutation_p.Q1512*|MYO18B_uc011aka.1_Nonsense_Mutation_p.Q786*|MYO18B_uc011akb.1_Nonsense_Mutation_p.Q1145*	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1632	Potential.|Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GAAAGTGACCCAGGAGAACAC	0.577			NA											8	2					0	0	0.00308	0	0
EMID1	129080	broad.mit.edu	37	22	29628272	29628272	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr22:29628272G>T	uc003aen.2	+	8	773	c.698G>T	c.(697-699)GGC>GTC	p.G233V	EMID1_uc003aem.2_Missense_Mutation_p.G235V|EMID1_uc003aeo.2_Missense_Mutation_p.G235V|EMID1_uc003aep.2_Missense_Mutation_p.G235V	NM_133455	NP_597712	Q96A84	EMID1_HUMAN	EMI domain containing 1	233	Collagen-like.					collagen					0						GGGAGCCCTGGCCGGGCTGGA	0.697			NA											20	47					7.87624e-14	1.18185e-13	0.00278	1	0
NEFH	4744	broad.mit.edu	37	22	29881762	29881762	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr22:29881762G>C	uc003afo.2	+	3	1205	c.1134G>C	c.(1132-1134)ATG>ATC	p.M378I		NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	378	Coil 2B.|Rod.				cell death|nervous system development	neurofilament					0						AGTGGGAGATGGCCGCCCAGC	0.572			NA											12	18					0	0	0.000978	0	0
SF3A1	10291	broad.mit.edu	37	22	30738840	30738840	+	Nonsense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr22:30738840G>C	uc003ahl.2	-	5	812	c.680C>G	c.(679-681)TCA>TGA	p.S227*		NM_005877	NP_005868	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa isoform 1	227					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			ovary(3)|large_intestine(1)|pancreas(1)	5						CTTGAGCTTTGAAAATAAACC	0.348			NA											9	62					0	0	0.000978	0	0
BPIL2	254240	broad.mit.edu	37	22	32841872	32841872	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr22:32841872G>T	uc003amn.2	-	4	486	c.486C>A	c.(484-486)TAC>TAA	p.Y162*	BPIL2_uc010gwo.2_5'UTR|BPIL2_uc011amb.1_Intron	NM_174932	NP_777592	Q8NFQ6	BPIL2_HUMAN	bactericidal/permeability-increasing	162						extracellular region	lipopolysaccharide binding|phospholipid binding			ovary(1)|skin(1)	2						TCAGTTGGGCGTAGCAATCTT	0.522			NA											6	44					0.00116845	0.00125927	0.001168	1	0
CYTH4	27128	broad.mit.edu	37	22	37690736	37690736	+	Silent	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr22:37690736A>G	uc003arf.2	+	3	254	c.138A>G	c.(136-138)CAA>CAG	p.Q46Q	CYTH4_uc003ard.3_Silent_p.Q46Q|CYTH4_uc003are.2_Silent_p.Q46Q|CYTH4_uc011amw.1_5'UTR|CYTH4_uc010gxe.2_Intron	NM_013385	NP_037517	Q9UIA0	CYH4_HUMAN	cytohesin 4	46	Potential.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						TGTTTGCCCAAATCGACTGCT	0.587			NA											20	68					0	0	0.002299	0	0
APOBEC3G	60489	broad.mit.edu	37	22	39483021	39483021	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr22:39483021A>T	uc003awx.2	+	7	1372	c.1030A>T	c.(1030-1032)AAG>TAG	p.K344*	APOBEC3G_uc003awy.2_Nonsense_Mutation_p.K277*	NM_021822	NP_068594	Q9HC16	ABC3G_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	344					base conversion or substitution editing|DNA cytosine deamination|innate immune response|interspecies interaction between organisms|negative regulation of retroviral genome replication|negative regulation of transposition|positive regulation of defense response to virus by host|response to virus|viral reproduction	apolipoprotein B mRNA editing enzyme complex|cytosol|mitochondrion	cytidine deaminase activity|dCTP deaminase activity|protein homodimerization activity|RNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2	Melanoma(58;0.04)					TTCAGAATTTAAGCACTGCTG	0.572			NA											17	44					0	0	0.00499	0	0
CACNA1I	8911	broad.mit.edu	37	22	40055735	40055735	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr22:40055735T>C	uc003ayc.2	+	14	2482	c.2482T>C	c.(2482-2484)TAC>CAC	p.Y828H	CACNA1I_uc003ayd.2_Missense_Mutation_p.Y793H|CACNA1I_uc003aye.2_Missense_Mutation_p.Y743H|CACNA1I_uc003ayf.2_Missense_Mutation_p.Y708H	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	828	Extracellular (Potential).|II.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CGTCGTTCTCTACAATGGCAT	0.577			NA											59	72					0	0	0.00361	0	0
ENTHD1	150350	broad.mit.edu	37	22	40283560	40283560	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr22:40283560C>A	uc003ayg.2	-	2	444	c.193G>T	c.(193-195)GGG>TGG	p.G65W		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	65	ENTH.									ovary(2)|skin(1)	3	Melanoma(58;0.0749)					CAGTTCTTCCCATGGTCATTG	0.413			NA											24	119					9.86323e-18	1.61073e-17	0.003954	1	0
SEPT3	55964	broad.mit.edu	37	22	42388689	42388689	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr22:42388689G>T	uc003bbr.3	+	8	925	c.787G>T	c.(787-789)GTG>TTG	p.V263L	WBP2NL_uc011ape.1_Intron|SEPT3_uc003bbs.3_Missense_Mutation_p.V263L|SEPT3_uc010gyr.2_Missense_Mutation_p.V199L|SEPT3_uc011apj.1_Missense_Mutation_p.V199L|SEPT3_uc010gys.2_Missense_Mutation_p.V43L	NM_145733	NP_663786	Q9UH03	SEPT3_HUMAN	septin 3 isoform A	263					cell cycle|cytokinesis	cell junction|septin complex	GTP binding				0						GCCTTTTGCTGTGGTGGGAAG	0.532			NA											3	13					0.00909568	0.00949057	0.009096	1	0
TTC38	55020	broad.mit.edu	37	22	46681155	46681155	+	Silent	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr22:46681155G>C	uc003bhi.2	+	9	889	c.813G>C	c.(811-813)GCG>GCC	p.A271A	TTC38_uc011aqx.1_Silent_p.A213A	NM_017931	NP_060401	Q5R3I4	TTC38_HUMAN	tetratricopeptide repeat domain 38	271	TPR 3.						binding			ovary(1)	1						ATGAGGCCGCGCTGACCATCT	0.468			NA											14	53					0	0	0.003163	0	0
SLC6A1	6529	broad.mit.edu	37	3	11070434	11070434	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:11070434G>A	uc010hdq.2	+	11	1503	c.1092G>A	c.(1090-1092)GCG>GCA	p.A364A		NM_003042	NP_003033	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter	364					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)|skin(1)	2		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	CCGGGCTGGCGTTCCTGGCAT	0.443			NA											9	18					0	0	0.006214	0	0
XPC	7508	broad.mit.edu	37	3	14199617	14199617	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:14199617C>G	uc011ave.1	-	9	1870	c.1766G>C	c.(1765-1767)TGG>TCG	p.W589S	XPC_uc011avf.1_Missense_Mutation_p.W396S|XPC_uc011avg.1_Missense_Mutation_p.W552S	NM_004628	NP_004619	Q01831	XPC_HUMAN	xeroderma pigmentosum, complementation group C	589	Interaction with RAD23B.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	cytoplasm|nucleoplasm|XPC complex	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding			ovary(2)|breast(1)	3						CACTGTCATCCAGACTGGGTC	0.557			NA	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		NER	Xeroderma_Pigmentosum				35	60					0	0	0.002836	0	0
HACL1	26061	broad.mit.edu	37	3	15628078	15628078	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:15628078G>A	uc003caf.2	-	6	573	c.413C>T	c.(412-414)TCT>TTT	p.S138F	HACL1_uc011avr.1_Intron|HACL1_uc011avs.1_Missense_Mutation_p.S111F|HACL1_uc011avt.1_Intron|HACL1_uc003cag.2_5'UTR|HACL1_uc011avu.1_Intron|HACL1_uc010hep.2_Intron	NM_012260	NP_036392	Q9UJ83	HACL1_HUMAN	2-hydroxyphytanoyl-CoA lyase	138					fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding				0						TGGGCGGGCAGAGAACTTGGT	0.358			NA											24	32					0	0	0.003954	0	0
PLCL2	23228	broad.mit.edu	37	3	17052968	17052968	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:17052968G>A	uc011awc.1	+	5	2211	c.2106G>A	c.(2104-2106)ATG>ATA	p.M702I	PLCL2_uc011awd.1_Missense_Mutation_p.M584I	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	710	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						CAGGACTGATGATGGACCTGA	0.468			NA											21	35					0	0	0.010504	0	0
NEK10	152110	broad.mit.edu	37	3	27213309	27213309	+	Splice_Site	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:27213309C>A	uc010hfk.2	-	8	996	c.767_splice	c.e8+1	p.R256_splice	NEK10_uc003cds.1_Splice_Site_p.R341_splice|NEK10_uc010hfj.2_Splice_Site_p.R256_splice			Q6ZWH5	NEK10_HUMAN	RecName: Full=Serine/threonine-protein kinase Nek10;          EC=2.7.11.1; AltName: Full=NimA-related protein kinase 10;								ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						TTTGCACCTACCTTGTTTGGG	0.358			NA											18	13					1.64113e-05	1.89019e-05	0.010504	1	0
STT3B	201595	broad.mit.edu	37	3	31638349	31638349	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:31638349C>T	uc011axe.1	+	4	771	c.771C>T	c.(769-771)TTC>TTT	p.F257F	STT3B_uc010hft.1_Silent_p.F257F|STT3B_uc003cer.1_Silent_p.F257F|STT3B_uc003cet.2_Silent_p.F8F	NM_178862	NP_849193	Q8TCJ2	STT3B_HUMAN	source of immunodominant MHC-associated	257	Helical; (Potential).				protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding				0						TATCCTATTTCTATATGGTAA	0.313			NA											4	39					0	0	0.009096	0	0
SCN11A	11280	broad.mit.edu	37	3	38889159	38889159	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:38889159C>A	uc011ays.1	-	26	4601	c.4402G>T	c.(4402-4404)GCT>TCT	p.A1468S		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1468	IV.|Helical; Voltage-sensor; Name=S4 of repeat IV; (By similarity).				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CCAATCCGAGCCAAGCGGACA	0.488			NA											8	20					0.00185496	0.0019917	0.001855	1	0
EXOSC7	23016	broad.mit.edu	37	3	45052814	45052814	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:45052814G>T	uc003coi.2	+	8	888	c.859G>T	c.(859-861)GTT>TTT	p.V287F	EXOSC7_uc003coh.1_Missense_Mutation_p.V222F|EXOSC7_uc010his.1_Missense_Mutation_p.V206F|EXOSC7_uc003coj.2_Missense_Mutation_p.V287F	NM_015004	NP_055819	Q15024	EXOS7_HUMAN	exosome component 7	287					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	3'-5'-exoribonuclease activity|protein binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00911)|KIRC - Kidney renal clear cell carcinoma(197;0.0509)|Kidney(197;0.064)		GAGACAGAAAGTTGGATTCCT	0.468			NA											10	4					2.74318e-10	3.69688e-10	0.006214	1	0
EXOSC7	23016	broad.mit.edu	37	3	45052818	45052818	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:45052818G>T	uc003coi.2	+	8	892	c.863G>T	c.(862-864)GGA>GTA	p.G288V	EXOSC7_uc003coh.1_Missense_Mutation_p.G223V|EXOSC7_uc010his.1_Missense_Mutation_p.G207V|EXOSC7_uc003coj.2_Missense_Mutation_p.G288V	NM_015004	NP_055819	Q15024	EXOS7_HUMAN	exosome component 7	288					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	3'-5'-exoribonuclease activity|protein binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00911)|KIRC - Kidney renal clear cell carcinoma(197;0.0509)|Kidney(197;0.064)		CAGAAAGTTGGATTCCTGGGA	0.453			NA											11	3					6.42651e-13	9.33236e-13	0.000978	1	0
LTF	4057	broad.mit.edu	37	3	46480871	46480871	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:46480871G>A	uc003cpq.2	-	15	1862	c.1824C>T	c.(1822-1824)TGC>TGT	p.C608C	LTF_uc003fzr.2_Silent_p.C564C|LTF_uc010hjh.2_Silent_p.C606C|LTF_uc003cpr.2_Silent_p.C595C	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor	608	Transferrin-like 2.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	TGGCAAGATGGCAGCTTCTAG	0.547			NA											25	21					0	0	0.003954	0	0
SETD2	29072	broad.mit.edu	37	3	47098323	47098323	+	Silent	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:47098323T>G	uc003cqs.2	-	15	7004	c.6951A>C	c.(6949-6951)CCA>CCC	p.P2317P	SETD2_uc003cqv.2_Silent_p.P2384P	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2317	Gln-rich.|Low charge region.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		GTACAATTGGTGGAGTTGTCT	0.403			NA	N|F|S|Mis		clear cell renal carcinoma								23	14					0	0	0.003954	0	0
UQCRC1	7384	broad.mit.edu	37	3	48637544	48637544	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:48637544C>T	uc003cub.1	-	11	1299	c.1254G>A	c.(1252-1254)CTG>CTA	p.L418L	UQCRC1_uc003cua.1_Silent_p.L303L|UQCRC1_uc003cuc.1_Silent_p.L419L|UQCRC1_uc003cud.1_Silent_p.L417L	NM_003365	NP_003356	P31930	QCR1_HUMAN	ubiquinol-cytochrome c reductase core protein I	418					aerobic respiration|proteolysis		metalloendopeptidase activity|ubiquinol-cytochrome-c reductase activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)	Atovaquone(DB01117)	GGCCATAGGTCAGGAGGCTGC	0.602	NSCLC(81;1112 1427 27031 32409 45529)		NA											7	33					0	0	0.006214	0	0
CELSR3	1951	broad.mit.edu	37	3	48697443	48697443	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:48697443G>T	uc003cul.2	-	1	2906	c.2625C>A	c.(2623-2625)AGC>AGA	p.S875R	CELSR3_uc003cuf.1_Missense_Mutation_p.S945R	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	875	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ccactatggtgctacccattg	0.363			NA											27	16					3.73808e-20	6.4018e-20	0.005443	1	0
DNAH1	25981	broad.mit.edu	37	3	52426606	52426606	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:52426606G>T	uc011bef.1	+	64	10440	c.10179G>T	c.(10177-10179)CAG>CAT	p.Q3393H	DNAH1_uc003ddv.2_Missense_Mutation_p.Q251H	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3458	Potential.|AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TTGAGGACCAGATCCTGTACC	0.562			NA											8	7					3.09899e-07	3.79672e-07	0.004482	1	0
DCP1A	55802	broad.mit.edu	37	3	53326447	53326447	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:53326447C>T	uc003dgs.3	-	7	1128	c.1035G>A	c.(1033-1035)GTG>GTA	p.V345V	DCP1A_uc003dgt.3_RNA	NM_018403	NP_060873	Q9NPI6	DCP1A_HUMAN	DCP1 decapping enzyme homolog A	345					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus	hydrolase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000164)|KIRC - Kidney renal clear cell carcinoma(197;0.00525)|Kidney(197;0.00579)|OV - Ovarian serous cystadenocarcinoma(275;0.0647)		GCGTGGTCTTCACTGCCTGCA	0.587			NA											12	20					0	0	0.000978	0	0
CACNA1D	776	broad.mit.edu	37	3	53699724	53699724	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:53699724G>T	uc003dgv.3	+	6	967	c.804G>T	c.(802-804)ATG>ATT	p.M268I	CACNA1D_uc003dgu.3_Missense_Mutation_p.M268I|CACNA1D_uc003dgy.3_Missense_Mutation_p.M268I|CACNA1D_uc003dgw.3_5'Flank	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	268	Cytoplasmic (Potential).|I.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TAAAAGCCATGGTTCCCCTCC	0.333			NA											34	31					9.8876e-21	1.70549e-20	0.004878	1	0
ERC2	26059	broad.mit.edu	37	3	56468732	56468732	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:56468732G>A	uc003dhr.1	-	2	560	c.304C>T	c.(304-306)CCC>TCC	p.P102S		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	102						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GCAATATTGGGACTACTCCCC	0.522			NA											22	56					0	0	0.00333	0	0
FAM3D	131177	broad.mit.edu	37	3	58622031	58622031	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:58622031G>T	uc003dkq.2	-	9	872	c.575C>A	c.(574-576)CCC>CAC	p.P192H		NM_138805	NP_620160	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D	192					negative regulation of insulin secretion	extracellular region	cytokine activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)		CTGCTCAAAGGGGCTTTTACC	0.572			NA											27	11					3.73808e-20	6.4018e-20	0.005443	1	0
MAGI1	9223	broad.mit.edu	37	3	65347012	65347012	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:65347012T>C	uc003dmn.2	-	22	4022	c.3496A>G	c.(3496-3498)ATT>GTT	p.I1166V	MAGI1_uc003dmm.2_Missense_Mutation_p.I1194V|MAGI1_uc003dmo.2_Missense_Mutation_p.I1195V|MAGI1_uc003dmp.2_Missense_Mutation_p.I1099V	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	1195	PDZ 6.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		TCATCACCAATCTGCCAAAGC	0.289			NA											16	38					0	0	0.003163	0	0
CNTN3	5067	broad.mit.edu	37	3	74334455	74334455	+	Splice_Site	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:74334455C>G	uc003dpm.1	-	19	2784	c.2704_splice	c.e19+1	p.P902_splice		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor						cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		AATATACTTACGCGTTTTCTT	0.428			NA											62	48					0	0	0.00361	0	0
ROBO1	6091	broad.mit.edu	37	3	78656106	78656106	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:78656106C>T	uc003dqe.2	-	29	4729	c.4521G>A	c.(4519-4521)GTG>GTA	p.V1507V	ROBO1_uc003dqb.2_Silent_p.V1468V|ROBO1_uc003dqc.2_Silent_p.V1407V|ROBO1_uc003dqd.2_Silent_p.V1462V|ROBO1_uc010hoh.2_Silent_p.V699V|ROBO1_uc011bgl.1_Silent_p.V1079V	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1507	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		GTTTTGGCACCACTACAGGTC	0.473			NA											52	41					0	0	0.00361	0	0
MINA	84864	broad.mit.edu	37	3	97686167	97686167	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:97686167T>A	uc003drz.1	-	2	777	c.271A>T	c.(271-273)AGC>TGC	p.S91C	MINA_uc003dsa.1_Missense_Mutation_p.S91C|MINA_uc003dsb.1_Missense_Mutation_p.S91C|MINA_uc003dsc.1_Missense_Mutation_p.S91C|MINA_uc010hpa.1_RNA|MINA_uc010hpb.1_Intron	NM_001042533	NP_001035998	Q8IUF8	MINA_HUMAN	MYC induced nuclear antigen isoform a	91					ribosome biogenesis	cytoplasm|nucleolus				ovary(1)	1						ATCCCCCGGCTGCACAGACTC	0.478			NA											112	232					0	0	0.00361	0	0
MYH15	22989	broad.mit.edu	37	3	108195258	108195258	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:108195258G>T	uc003dxa.1	-	13	1336	c.1279C>A	c.(1279-1281)CAA>AAA	p.Q427K		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	427	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						TCTATAGTTTGACCTCTGGTA	0.338			NA											17	15					7.07596e-05	7.95287e-05	0.006122	1	0
DZIP3	9666	broad.mit.edu	37	3	108392970	108392970	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:108392970G>T	uc003dxd.2	+	24	3057	c.2635G>T	c.(2635-2637)GAG>TAG	p.E879*	DZIP3_uc003dxf.1_Nonsense_Mutation_p.E879*|DZIP3_uc011bhm.1_Nonsense_Mutation_p.E330*	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	879					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GCTTCATCTAGAGCAGACTGA	0.408			NA											72	59					5.42381e-49	1.04004e-48	0.00361	1	0
SLC9A10	285335	broad.mit.edu	37	3	111898518	111898518	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:111898518C>T	uc003dyu.2	-	23	3001	c.2779G>A	c.(2779-2781)GAT>AAT	p.D927N	SLC9A10_uc011bhu.1_Missense_Mutation_p.D190N|SLC9A10_uc010hqc.2_Missense_Mutation_p.D879N	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	927	cNMP.				cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						ACCATTTGATCAATCCCTAAA	0.338			NA											6	44					0	0	0.001168	0	0
CD200R1	131450	broad.mit.edu	37	3	112647867	112647867	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:112647867C>A	uc003dzk.1	-	4	729	c.496G>T	c.(496-498)GTA>TTA	p.V166L	CD200R1_uc003dzj.1_Missense_Mutation_p.V189L|CD200R1_uc011bhx.1_Missense_Mutation_p.V144L|CD200R1_uc003dzl.1_3'UTR|CD200R1_uc003dzm.1_3'UTR	NM_170780	NP_740750	Q8TD46	MO2R1_HUMAN	CD200 receptor 1 isoform d	166	Ig-like C2-type.|Extracellular (Potential).				interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			ovary(2)|pancreas(1)	3						GCCTTGCATACTGCAGTTCTA	0.473			NA											34	14					2.80507e-11	3.88934e-11	0.002445	1	0
GRAMD1C	54762	broad.mit.edu	37	3	113594425	113594425	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:113594425G>T	uc003eaq.3	+	4	430	c.354G>T	c.(352-354)TGG>TGT	p.W118C	GRAMD1C_uc011bil.1_RNA|GRAMD1C_uc011bim.1_RNA	NM_017577	NP_060047	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	118	GRAM.					integral to membrane				ovary(2)|skin(1)	3						TCTTCAGATGGGAAACTACAG	0.338			NA											33	56					1.21669e-08	1.57634e-08	0.003271	1	0
GRAMD1C	54762	broad.mit.edu	37	3	113659180	113659180	+	Silent	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:113659180G>C	uc003eaq.3	+	17	1972	c.1896G>C	c.(1894-1896)GTG>GTC	p.V632V	GRAMD1C_uc011bil.1_RNA|GRAMD1C_uc003ear.2_Silent_p.V465V|GRAMD1C_uc003eas.2_Silent_p.V427V|GRAMD1C_uc003eat.2_Silent_p.V291V	NM_017577	NP_060047	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	632						integral to membrane				ovary(2)|skin(1)	3						ACTCCATAGTGATGCTTGAAC	0.408			NA											31	94					0	0	0.003271	0	0
CD86	942	broad.mit.edu	37	3	121822406	121822406	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:121822406C>A	uc003eet.2	+	3	228	c.112C>A	c.(112-114)CTG>ATG	p.L38M	CD86_uc011bjo.1_Translation_Start_Site|CD86_uc011bjp.1_Intron|CD86_uc003eeu.2_Missense_Mutation_p.L32M	NM_175862	NP_787058	P42081	CD86_HUMAN	CD86 antigen isoform 1	38	Ig-like V-type.|Extracellular (Potential).				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			pancreas(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	GACTGCAGACCTGCCATGCCA	0.428	GBM(67;1379 1389 36064 39806)		NA											11	60					6.40141e-05	7.21159e-05	0.000978	1	0
ADCY5	111	broad.mit.edu	37	3	123019011	123019011	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:123019011G>A	uc003egh.1	-	15	2856	c.2856C>T	c.(2854-2856)GTC>GTT	p.V952V	ADCY5_uc003egg.1_Silent_p.V585V|ADCY5_uc003egi.1_Silent_p.V511V	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	952	Helical; (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		CGAAGAGCGTGACACCTGGCA	0.622			NA											11	52					0	0	0.000978	0	0
OSBPL11	114885	broad.mit.edu	37	3	125298818	125298818	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:125298818C>T	uc003eic.2	-	3	1037	c.300G>A	c.(298-300)CAG>CAA	p.Q100Q		NM_022776	NP_073613	Q9BXB4	OSB11_HUMAN	oxysterol binding protein-like 11	100	PH.				lipid transport		lipid binding			ovary(3)|breast(1)|kidney(1)	5						CTCTAGGTTTCTGATTTCTAG	0.378			NA											29	73					0	0	0.007291	0	0
IFT122	55764	broad.mit.edu	37	3	129195286	129195286	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:129195286G>T	uc003emm.2	+	10	1151	c.945G>T	c.(943-945)GGG>GGT	p.G315G	IFT122_uc003eml.2_Silent_p.G366G|IFT122_uc003emn.2_Silent_p.G256G|IFT122_uc003emo.2_Silent_p.G204G|IFT122_uc003emp.2_Silent_p.G165G|IFT122_uc010htc.2_Silent_p.G307G|IFT122_uc011bky.1_Silent_p.G106G|IFT122_uc003emq.2_Silent_p.G155G|IFT122_uc003emr.2_Silent_p.G106G|IFT122_uc011bla.1_Silent_p.G106G|IFT122_uc011bkx.1_Silent_p.G155G|IFT122_uc011bkz.1_RNA	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	315	WD 5.				camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						TGCGGCTTGGGACTGTTGGGG	0.507			NA											20	98					1.22574e-08	1.58379e-08	0.002299	1	0
TOPBP1	11073	broad.mit.edu	37	3	133368263	133368263	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:133368263G>A	uc003eps.2	-	10	1600	c.1468C>T	c.(1468-1470)CTG>TTG	p.L490L		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	490					DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						TGAGAGAGCAGATCTTCATCA	0.353	Ovarian(21;193 658 4424 15423 17362)		NA						Other_conserved_DNA_damage_response_genes					13	46					0	0	0.00245	0	0
SOX14	8403	broad.mit.edu	37	3	137483993	137483993	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:137483993G>T	uc003erm.1	+	1	415	c.367G>T	c.(367-369)GAG>TAG	p.E123*		NM_004189	NP_004180	O95416	SOX14_HUMAN	SRY-box 14	123					negative regulation of transcription from RNA polymerase II promoter|nervous system development|transcription, DNA-dependent	nucleus	sequence-specific DNA binding				0						GAGCGCGCCCGAGAAAGCCCG	0.706			NA											18	18					4.75885e-15	7.33932e-15	0.00499	1	0
CLDN18	51208	broad.mit.edu	37	3	137742562	137742562	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:137742562C>T	uc003ero.1	+	2	336	c.283C>T	c.(283-285)CTG>TTG	p.L95L	CLDN18_uc003erp.1_Silent_p.L95L|CLDN18_uc010hue.1_Missense_Mutation_p.P90L	NM_001002026	NP_001002026	P56856	CLD18_HUMAN	claudin 18 isoform 2	95	Helical; (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			upper_aerodigestive_tract(1)|ovary(1)	2						CATTGGCCTCCTGGTATCCAT	0.547			NA											39	31					0	0	0.005524	0	0
SLC9A9	285195	broad.mit.edu	37	3	142985726	142985726	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:142985726C>A	uc003evn.2	-	16	1938	c.1756G>T	c.(1756-1758)GAA>TAA	p.E586*		NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	586					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						ATGGCTAGTTCATCCTGGTTT	0.493			NA											53	40					2.48254e-18	4.1006e-18	0.00361	1	0
ZIC4	84107	broad.mit.edu	37	3	147108856	147108856	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:147108856C>A	uc003ewd.1	-	4	1139	c.866G>T	c.(865-867)GGG>GTG	p.G289V	ZIC4_uc003ewc.1_Missense_Mutation_p.G219V|ZIC4_uc011bno.1_Missense_Mutation_p.G339V	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	289						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						CGGCGAGCGCCCGTGCACCTT	0.662			NA											36	26					2.32173e-10	3.13184e-10	0.004878	1	0
ZIC1	7545	broad.mit.edu	37	3	147130396	147130396	+	Missense_Mutation	SNP	C	C	A	rs138369951	by1000genomes	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:147130396C>A	uc003ewe.2	+	2	1793	c.1074C>A	c.(1072-1074)AGC>AGA	p.S358R		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	358					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						TGCACACGAGCGACAAGCCCT	0.582			NA											40	77					7.05121e-23	1.25066e-22	0.002522	1	0
MME	4311	broad.mit.edu	37	3	154834294	154834294	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:154834294G>C	uc010hvr.1	+	5	596	c.385G>C	c.(385-387)GAT>CAT	p.D129H	MME_uc003fab.1_Missense_Mutation_p.D129H|MME_uc003fac.1_Missense_Mutation_p.D129H|MME_uc003fad.1_Missense_Mutation_p.D129H|MME_uc003fae.1_Missense_Mutation_p.D129H	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	129	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CAAAACTGAAGATATAGTAGC	0.308			NA											32	38					0	0	0.006999	0	0
SHOX2	6474	broad.mit.edu	37	3	157815970	157815970	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:157815970G>T	uc003fbr.2	-	5	981	c.842C>A	c.(841-843)CCC>CAC	p.P281H	SHOX2_uc003fbs.2_Missense_Mutation_p.P305H|SHOX2_uc010hvw.2_Missense_Mutation_p.P269H	NM_006884	NP_006875	O60902	SHOX2_HUMAN	short stature homeobox 2 isoform a	281					nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			CAGTCCGAAGGGCGGTGCTGG	0.711			NA											71	54					2.32817e-41	4.45255e-41	0.00361	1	0
PLD1	5337	broad.mit.edu	37	3	171451267	171451267	+	Silent	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:171451267T>C	uc003fhs.2	-	6	689	c.573A>G	c.(571-573)CTA>CTG	p.L191L	PLD1_uc003fht.2_Silent_p.L191L	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	191	PX.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TGGGCATTTTTAGTATCTTTG	0.279	NSCLC(149;2174 3517 34058)		NA											24	46					0	0	0.007291	0	0
PIK3CA	5290	broad.mit.edu	37	3	178937410	178937410	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:178937410G>A	uc003fjk.2	+	12	1955	c.1798G>A	c.(1798-1800)GAA>AAA	p.E600K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	600	PI3K helical.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ACAGGCTATGGAACTTCTGGA	0.363	Colon(199;1504 1750 3362 26421 31210 32040)		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			11	27					0	0	0.004007	0	0
AP2M1	1173	broad.mit.edu	37	3	183896904	183896904	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:183896904C>T	uc011bqx.1	+	3	491	c.334C>T	c.(334-336)CTG>TTG	p.L112L	AP2M1_uc003fmw.2_Silent_p.L112L|AP2M1_uc003fmx.2_Silent_p.L112L|AP2M1_uc003fmy.2_Silent_p.L112L|AP2M1_uc011bqy.1_5'Flank|AP2M1_uc011bqz.1_5'Flank	NM_004068	NP_004059	Q96CW1	AP2M1_HUMAN	adaptor-related protein complex 2, mu 1 subunit	112					axon guidance|cellular membrane organization|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|clathrin coat of coated pit|cytosol|endocytic vesicle membrane|peroxisomal membrane	lipid binding|protein binding|transporter activity				0	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.92e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ATATGAGCTGCTGGATGGTGA	0.547			NA											84	41					0	0	0.00361	0	0
EHHADH	1962	broad.mit.edu	37	3	184910364	184910364	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:184910364G>C	uc003fpf.2	-	7	1849	c.1822C>G	c.(1822-1824)CAC>GAC	p.H608D	EHHADH_uc011brs.1_Missense_Mutation_p.H512D	NM_001966	NP_001957	Q08426	ECHP_HUMAN	enoyl-Coenzyme A, hydratase/3-hydroxyacyl	608						peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			ovary(3)	3	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	GGTTCAATGTGATGGGTTTTT	0.438			NA											14	145					0	0	0.00245	0	0
EHHADH	1962	broad.mit.edu	37	3	184910516	184910516	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:184910516C>A	uc003fpf.2	-	7	1697	c.1670G>T	c.(1669-1671)AGG>ATG	p.R557M	EHHADH_uc011brs.1_Missense_Mutation_p.R461M	NM_001966	NP_001957	Q08426	ECHP_HUMAN	enoyl-Coenzyme A, hydratase/3-hydroxyacyl	557	3-hydroxyacyl-CoA dehydrogenase.					peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			ovary(3)	3	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	TGGGCAGTACCTCCTATTACC	0.488			NA											62	35					2.66076e-39	5.07515e-39	0.00361	1	0
HRG	3273	broad.mit.edu	37	3	186394987	186394987	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:186394987C>A	uc003fqq.2	+	7	916	c.893C>A	c.(892-894)CCA>CAA	p.P298Q		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	298	Pro-rich.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		CATGGACCCCCACCTCCTCCA	0.542			NA											20	110					3.10358e-05	3.5547e-05	0.002299	1	0
BCL6	604	broad.mit.edu	37	3	187447752	187447752	+	Silent	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:187447752C>G	uc003frp.3	-	5	898	c.441G>C	c.(439-441)CGG>CGC	p.R147R	BCL6_uc011bsf.1_Silent_p.R147R|BCL6_uc010hza.2_Silent_p.R45R|BCL6_uc003frq.1_Silent_p.R147R	NM_001130845	NP_001124317	P41182	BCL6_HUMAN	B-cell lymphoma 6 protein isoform 1	147					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|lung(2)|central_nervous_system(1)	5	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		GCATCAGCATCCGGCTGTTGA	0.547			NA	T|Mis	IG loci|ZNFN1A1|LCP1|PIM1|TFRC|MHC2TA|NACA|HSPCB|HSPCA|HIST1H4I|IL21R| POU2AF1|ARHH|EIF4A2|SFRS3	NHL|CLL								7	119					0	0	0.00308	0	0
BCL6	604	broad.mit.edu	37	3	187447769	187447769	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:187447769C>G	uc003frp.3	-	5	881	c.424G>C	c.(424-426)GAG>CAG	p.E142Q	BCL6_uc011bsf.1_Missense_Mutation_p.E142Q|BCL6_uc010hza.2_Missense_Mutation_p.E40Q|BCL6_uc003frq.1_Missense_Mutation_p.E142Q	NM_001130845	NP_001124317	P41182	BCL6_HUMAN	B-cell lymphoma 6 protein isoform 1	142					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|lung(2)|central_nervous_system(1)	5	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		TTGAGGAACTCTTCACGAGGA	0.527			NA	T|Mis	IG loci|ZNFN1A1|LCP1|PIM1|TFRC|MHC2TA|NACA|HSPCB|HSPCA|HIST1H4I|IL21R| POU2AF1|ARHH|EIF4A2|SFRS3	NHL|CLL								7	115					0	0	0.001984	0	0
MFSD7	84179	broad.mit.edu	37	4	675791	675791	+	Missense_Mutation	SNP	C	C	A	rs143423821	by1000genomes	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:675791C>A	uc003gay.2	-	10	1696	c.1639G>T	c.(1639-1641)GCT>TCT	p.A547S	MYL5_uc003gat.2_RNA|MYL5_uc003gau.2_RNA|MYL5_uc003gav.2_3'UTR|MFSD7_uc003gaw.2_Missense_Mutation_p.A289S|MFSD7_uc003gax.2_Missense_Mutation_p.A546S|MFSD7_uc003gaz.2_Missense_Mutation_p.A428S|MFSD7_uc003gba.2_Missense_Mutation_p.A450S|MFSD7_uc003gbb.1_3'UTR	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	547					transmembrane transport	integral to membrane					0						TGAGACCCAGCCGGGTCAATA	0.662			NA											6	13					2.7689e-08	3.53028e-08	0.001984	1	0
DRD5	1816	broad.mit.edu	37	4	9783849	9783849	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:9783849G>T	uc003gmb.3	+	1	592	c.196G>T	c.(196-198)GTG>TTG	p.V66L		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	66	Helical; Name=1; (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CGCAGCCATCGTGCGGAGCCG	0.652			NA											8	16					0.00307968	0.003275	0.00308	1	0
DRD5	1816	broad.mit.edu	37	4	9783943	9783943	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:9783943G>T	uc003gmb.3	+	1	686	c.290G>T	c.(289-291)TGG>TTG	p.W97L		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	97	Helical; Name=2; (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	GTCATGCCCTGGAAGGCAGTC	0.627			NA											14	36					6.31663e-08	7.96204e-08	0.003163	1	0
DRD5	1816	broad.mit.edu	37	4	9784087	9784087	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:9784087C>A	uc003gmb.3	+	1	830	c.434C>A	c.(433-435)CCC>CAC	p.P145H		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	145	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	ATCTCCAGGCCCTTCCGCTAC	0.597			NA											9	17					1.12685e-05	1.30516e-05	0.004482	1	0
CC2D2A	57545	broad.mit.edu	37	4	15581639	15581639	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:15581639C>T	uc010idv.2	+	31	4065	c.3820C>T	c.(3820-3822)CAA>TAA	p.Q1274*	CC2D2A_uc003gnx.2_Nonsense_Mutation_p.Q1166*|CC2D2A_uc003gnz.1_RNA|CC2D2A_uc003goa.1_RNA	NM_001080522	NP_001073991	Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A isoform	1274					cell projection organization	cilium|microtubule basal body				pancreas(2)|ovary(1)	3						TGAGAAGTTTCAAGCTGAATG	0.343			NA											7	74					0	0	0.006214	0	0
STIM2	57620	broad.mit.edu	37	4	27019334	27019334	+	Silent	SNP	G	G	T	rs140282649		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:27019334G>T	uc003gsh.3	+	12	1992	c.1776G>T	c.(1774-1776)GGG>GGT	p.G592G	STIM2_uc003gsg.3_Silent_p.G584G|STIM2_uc010iex.2_Silent_p.G584G|STIM2_uc010iey.2_Silent_p.G208G	NM_020860	NP_065911	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	497	Cytoplasmic (Potential).				activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			central_nervous_system(1)|skin(1)	2		Breast(46;0.0503)				GTTTTTCAGGGACCATGGCTA	0.507			NA											27	85					0.000117367	0.000130892	0.005443	1	0
PCDH7	5099	broad.mit.edu	37	4	30725755	30725755	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:30725755G>T	uc003gsk.1	+	1	3719	c.2711G>T	c.(2710-2712)TGC>TTC	p.C904F	PCDH7_uc011bxw.1_Missense_Mutation_p.C857F|PCDH7_uc011bxx.1_Missense_Mutation_p.C904F	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	904	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						GCAAGGTACTGCAGGTCCAAA	0.388			NA											22	250					1.22574e-08	1.58379e-08	0.002299	1	0
ATP10D	57205	broad.mit.edu	37	4	47517562	47517562	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:47517562G>T	uc003gxk.1	+	3	524	c.360G>T	c.(358-360)AAG>AAT	p.K120N	ATP10D_uc003gxj.3_Missense_Mutation_p.K120N	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	120	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						CCTTCCAAAAGGAAATCACCA	0.413			NA											23	64					5.35356e-11	7.35923e-11	0.00278	1	0
KIAA1211	57482	broad.mit.edu	37	4	57181941	57181941	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:57181941C>G	uc003hbk.2	+	8	2664	c.2273C>G	c.(2272-2274)GCC>GGC	p.A758G	KIAA1211_uc010iha.2_Missense_Mutation_p.A751G|KIAA1211_uc011bzz.1_Missense_Mutation_p.A668G|KIAA1211_uc003hbm.1_Missense_Mutation_p.A644G	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	758										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					GAAGAGACAGCCCCCCAGCCT	0.592			NA											17	17					0	0	0.004007	0	0
TECRL	253017	broad.mit.edu	37	4	65146797	65146797	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:65146797G>T	uc003hcv.2	-	11	1035	c.926C>A	c.(925-927)TCA>TAA	p.S309*	TECRL_uc010ihi.2_Intron	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	309					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						ACTAATCCATGATCCAATCTG	0.284			NA											12	50					0.000219431	0.000243213	0.00245	1	0
TECRL	253017	broad.mit.edu	37	4	65275040	65275040	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:65275040C>T	uc003hcv.2	-	1	139	c.30G>A	c.(28-30)TCG>TCA	p.S10S	TECRL_uc003hcw.2_Silent_p.S10S	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	10					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						TCTTGCGTTCCGAAGCGAGGG	0.413			NA											27	61					0	0	0.009535	0	0
TECRL	253017	broad.mit.edu	37	4	65275046	65275046	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:65275046G>T	uc003hcv.2	-	1	133	c.24C>A	c.(22-24)CTC>CTA	p.L8L	TECRL_uc003hcw.2_Silent_p.L8L	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	8					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						GTTCCGAAGCGAGGGACTTGT	0.393			NA											26	63					1.5548e-18	2.57113e-18	0.005443	1	0
UBA6	55236	broad.mit.edu	37	4	68504713	68504713	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:68504713C>A	uc003hdg.3	-	19	1736	c.1684G>T	c.(1684-1686)GAT>TAT	p.D562Y	UBA6_uc003hdh.1_Missense_Mutation_p.D88Y	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	562					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						ATAATTACATCTTGTTTAGTA	0.333			NA											27	50					9.80776e-20	1.65801e-19	0.00632	1	0
TMPRSS11F	389208	broad.mit.edu	37	4	68919700	68919700	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:68919700A>C	uc003hdt.1	-	10	1293	c.1244T>G	c.(1243-1245)CTT>CGT	p.L415R	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	415	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						TTTTTTGGGAAGTGCACATGA	0.403			NA											13	70					0	0	0.00245	0	0
GRSF1	2926	broad.mit.edu	37	4	71698153	71698153	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:71698153T>A	uc010iia.1	-	4	768	c.685A>T	c.(685-687)AAT>TAT	p.N229Y	GRSF1_uc011caz.1_Missense_Mutation_p.N111Y|GRSF1_uc003hfs.2_Missense_Mutation_p.N67Y	NM_002092	NP_002083	Q12849	GRSF1_HUMAN	G-rich RNA sequence binding factor 1 isoform 1	229	RRM 1.				mRNA polyadenylation		mRNA binding|nucleotide binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			ACATCTTCATTGTTTATCTCA	0.368			NA											3	24					0	0	0.004672	0	0
NAA11	84779	broad.mit.edu	37	4	80246951	80246951	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:80246951C>A	uc003hlt.3	-	1	221	c.81G>T	c.(79-81)CAG>CAT	p.Q27H		NM_032693	NP_116082	Q9BSU3	NAA11_HUMAN	alpha-N-acetyltransferase 1B	27	Interaction with NAA15 (By similarity).|N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2						AGTATTTCATCTGGTAGTTCT	0.488			NA											29	27					6.07407e-21	1.04896e-20	0.007291	1	0
PKD2	5311	broad.mit.edu	37	4	88983142	88983142	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:88983142G>T	uc003hre.2	+	10	2170	c.2104G>T	c.(2104-2106)GAT>TAT	p.D702Y	PKD2_uc011cdf.1_Missense_Mutation_p.D120Y|PKD2_uc011cdg.1_Missense_Mutation_p.D28Y|PKD2_uc011cdh.1_5'UTR	NM_000297	NP_000288	Q13563	PKD2_HUMAN	polycystin 2	702	Cytoplasmic (Potential).					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			skin(1)	1		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		GGAACTCTCAGATCTTATCAG	0.333			NA											40	15					2.00842e-17	3.25775e-17	0.002522	1	0
GPRIN3	285513	broad.mit.edu	37	4	90169436	90169436	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:90169436G>A	uc003hsm.1	-	2	2345	c.1826C>T	c.(1825-1827)TCT>TTT	p.S609F		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	609										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		CATGGGATCAGATGGCAGGCT	0.582			NA											26	58					0	0	0.009535	0	0
ANK2	287	broad.mit.edu	37	4	114171000	114171000	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:114171000C>T	uc003ibe.3	+	10	1072	c.972C>T	c.(970-972)CCC>CCT	p.P324P	ANK2_uc003ibd.3_Silent_p.P303P|ANK2_uc003ibf.3_Silent_p.P324P|ANK2_uc003ibc.2_Silent_p.P300P|ANK2_uc011cgb.1_Silent_p.P339P	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	324	ANK 9.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GGGGTGCCCCCTTGCTGGCAA	0.423			NA											8	9					0	0	0.004482	0	0
ANK2	287	broad.mit.edu	37	4	114286205	114286205	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:114286205C>A	uc003ibe.3	+	41	10999	c.10899C>A	c.(10897-10899)CTC>CTA	p.L3633L	ANK2_uc003ibd.3_Silent_p.L1539L|ANK2_uc003ibf.3_Silent_p.L1548L|ANK2_uc011cgc.1_Silent_p.L724L|ANK2_uc003ibg.3_Silent_p.L532L|ANK2_uc003ibh.3_Silent_p.L222L|ANK2_uc011cgd.1_Silent_p.L935L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3600	Death.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATACCAACCTCGTTGAATGTC	0.388			NA											22	53					1.77063e-15	2.75432e-15	0.005443	1	0
CAMK2D	817	broad.mit.edu	37	4	114680554	114680554	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:114680554C>A	uc003ibi.2	-	2	941	c.82G>T	c.(82-84)GTG>TTG	p.V28L	CAMK2D_uc003ibj.2_Missense_Mutation_p.V28L|CAMK2D_uc003ibk.2_Missense_Mutation_p.V28L|CAMK2D_uc003ibo.3_Missense_Mutation_p.V28L|CAMK2D_uc003ibm.2_Missense_Mutation_p.V28L|CAMK2D_uc003ibn.2_Missense_Mutation_p.V28L|CAMK2D_uc003ibl.2_Missense_Mutation_p.V28L	NM_001221	NP_001212	Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II	28	ATP (By similarity).|Protein kinase.				interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		CATCTTCTCACCACTGAGAAT	0.323			NA											36	76					1.47197e-15	2.29468e-15	0.007835	1	0
NDST4	64579	broad.mit.edu	37	4	115856447	115856447	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:115856447A>G	uc003ibu.2	-	6	2130	c.1451T>C	c.(1450-1452)TTC>TCC	p.F484S	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	484	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TTCTTTGTAGAAAATAGTGTG	0.403			NA											12	26					0	0	0.001368	0	0
PRDM5	11107	broad.mit.edu	37	4	121675745	121675745	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:121675745T>C	uc003idn.2	-	14	1836	c.1586A>G	c.(1585-1587)AAT>AGT	p.N529S	PRDM5_uc003ido.2_Missense_Mutation_p.N498S|PRDM5_uc010ine.2_Intron	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	529	C2H2-type 13.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						CAGTCCATCATTTTTACTGAA	0.343			NA											11	26					0	0	0.001855	0	0
PCDH10	57575	broad.mit.edu	37	4	134084222	134084222	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:134084222G>C	uc003iha.2	+	4	3714	c.2888G>C	c.(2887-2889)GGA>GCA	p.G963A		NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	963	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CCTTCTGATGGACGCCAGGCT	0.522			NA											27	29					0	0	0.003954	0	0
UCP1	7350	broad.mit.edu	37	4	141484331	141484331	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:141484331G>A	uc011chj.1	-	4	637	c.561C>T	c.(559-561)ATC>ATT	p.I187I	UCP1_uc011chk.1_Silent_p.I186I	NM_021833	NP_068605	P25874	UCP1_HUMAN	uncoupling protein 1	187	Helical; Name=4; (Potential).|Solcar 2.				brown fat cell differentiation|cellular lipid metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	binding			ovary(1)	1	all_hematologic(180;0.162)					CTGTACAATTGATGATGACAC	0.338			NA											23	49					0	0	0.005443	0	0
RNF150	57484	broad.mit.edu	37	4	141888788	141888788	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:141888788C>A	uc003iio.1	-	2	1378	c.724G>T	c.(724-726)GAT>TAT	p.D242Y	RNF150_uc010iok.1_Intron|RNF150_uc003iip.1_Missense_Mutation_p.D242Y	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	242	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					TGGTTCCTATCCCTGGCATTT	0.363			NA											32	14					3.1745e-13	4.66628e-13	0.008361	1	0
TTC29	83894	broad.mit.edu	37	4	147796051	147796051	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:147796051C>A	uc003ikw.3	-	7	843	c.616G>T	c.(616-618)GAA>TAA	p.E206*	TTC29_uc010ipc.2_RNA|TTC29_uc003ikx.3_Nonsense_Mutation_p.E232*|TTC29_uc010ipd.1_Nonsense_Mutation_p.E206*	NM_031956	NP_114162	Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	206	TPR 1.						binding				0	all_hematologic(180;0.151)					TGGAATGCTTCATAATGCTCA	0.448			NA											21	10					3.83957e-06	4.50868e-06	0.00278	1	0
MARCH1	55016	broad.mit.edu	37	4	164506997	164506997	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:164506997G>T	uc003iqs.1	-	6	1304	c.327C>A	c.(325-327)TCC>TCA	p.S109S	MARCH1_uc003iqr.1_Silent_p.S92S	NM_017923	NP_060393	Q8TCQ1	MARH1_HUMAN	membrane-associated RING-CH protein I	109	RING-CH-type.				antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GGTGGAGGCAGGACTGGTGGA	0.542			NA											7	33					1.6384e-10	2.21422e-10	0.001984	1	0
TRIM61	391712	broad.mit.edu	37	4	165891118	165891118	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:165891118C>T	uc003iqw.2	-	3	648	c.37G>A	c.(37-39)GAG>AAG	p.E13K		NM_001012414	NP_001012414	Q5EBN2	TRI61_HUMAN	tripartite motif-containing 61	13						intracellular	zinc ion binding			skin(1)	1	all_hematologic(180;0.221)	Prostate(90;0.109)		GBM - Glioblastoma multiforme(119;0.155)		CAGCTAGCCTCTGCTCGGAGG	0.473			NA											7	73					0	0	0.006214	0	0
Unknown	0	broad.mit.edu	37	4	165981373	165981373	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:165981373G>T	uc011cjl.1	+	1	1074	c.1074G>T	c.(1072-1074)AAG>AAT	p.K358N		NM_001105575	NP_001099045			tripartite motif-containing 75												NA						TGGGGGATAAGTCAGAATGGG	0.463			NA											57	49					2.40265e-35	4.53484e-35	0.00361	1	0
TLL1	7092	broad.mit.edu	37	4	166981261	166981261	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:166981261A>G	uc003irh.1	+	15	2575	c.1928A>G	c.(1927-1929)AAC>AGC	p.N643S	TLL1_uc011cjn.1_Missense_Mutation_p.N666S|TLL1_uc011cjo.1_Missense_Mutation_p.N467S	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	643	CUB 3.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		CCTAATAAGAACTGTGTGTGG	0.428			NA											13	16					0	0	0.001368	0	0
SPOCK3	50859	broad.mit.edu	37	4	167656143	167656143	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:167656143C>T	uc003iri.1	-	12	1381	c.1240G>A	c.(1240-1242)GAA>AAA	p.E414K	SPOCK3_uc011cjp.1_Missense_Mutation_p.E371K|SPOCK3_uc011cjq.1_Missense_Mutation_p.E423K|SPOCK3_uc011cjr.1_Missense_Mutation_p.E294K|SPOCK3_uc003irj.1_Missense_Mutation_p.E411K|SPOCK3_uc011cjs.1_Missense_Mutation_p.E363K|SPOCK3_uc011cjt.1_Missense_Mutation_p.E322K|SPOCK3_uc011cju.1_Missense_Mutation_p.E307K|SPOCK3_uc011cjv.1_Missense_Mutation_p.E316K	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	414	Asp-rich.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		tcttcaatttcatcttcatca	0.06			NA											9	24					0	0	0.004482	0	0
MFAP3L	9848	broad.mit.edu	37	4	170912639	170912639	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:170912639T>A	uc003isp.3	-	3	1298	c.1120A>T	c.(1120-1122)ACA>TCA	p.T374S	MFAP3L_uc003isn.3_Missense_Mutation_p.T271S	NM_021647	NP_067679	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like isoform	374	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)		TCAACAGGTGTTGGCTCTTCA	0.502			NA											41	38					0	0	0.007835	0	0
WDR17	116966	broad.mit.edu	37	4	177032808	177032808	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:177032808G>T	uc003iuj.2	+	3	305	c.149G>T	c.(148-150)GGA>GTA	p.G50V	WDR17_uc003iuk.2_Missense_Mutation_p.G26V|WDR17_uc003ium.3_Missense_Mutation_p.G26V|WDR17_uc003iul.1_Missense_Mutation_p.G26V	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	50										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		GCTGCCAGTGGAGACAGGTTT	0.378			NA											15	29					1.02788e-11	1.44747e-11	0.00499	1	0
FAT1	2195	broad.mit.edu	37	4	187628590	187628590	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:187628590C>A	uc003izf.2	-	2	2580	c.2392G>T	c.(2392-2394)GGG>TGG	p.G798W	FAT1_uc010iso.1_Missense_Mutation_p.G798W	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	798	Extracellular (Potential).|Cadherin 6.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGGGGTATCCCAAGGTCATAG	0.433	Colon(197;1040 2055 4143 4984 49344)		NA								HNSCC(5;0.00058)			51	28					2.3441e-25	4.27872e-25	0.00361	1	0
PLEKHG4B	153478	broad.mit.edu	37	5	156309	156309	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:156309G>C	uc003jak.2	+	8	1314	c.1264G>C	c.(1264-1266)GGC>CGC	p.G422R		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	422					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AGAAGAGCTTGGCACAGAAGA	0.637			NA											16	30					0	0	0.003163	0	0
SEMA5A	9037	broad.mit.edu	37	5	9054200	9054200	+	Silent	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:9054200T>G	uc003jek.2	-	19	3400	c.2688A>C	c.(2686-2688)CCA>CCC	p.P896P		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	896	TSP type-1 6.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GCCGCTTACCTGGGCAGGGCT	0.537			NA											25	38					0	0	0.00632	0	0
FAM173B	134145	broad.mit.edu	37	5	10227603	10227603	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:10227603C>A	uc003jeo.2	-	5	681	c.652G>T	c.(652-654)GAA>TAA	p.E218*	FAM173B_uc003jep.2_RNA|FAM173B_uc010itr.2_Nonsense_Mutation_p.E201*	NM_199133	NP_954584	Q6P4H8	F173B_HUMAN	hypothetical protein LOC134145	218						integral to membrane				kidney(1)|central_nervous_system(1)	2						GGCCTCTTTTCACGGCCTCTA	0.493			NA											29	43					4.31634e-10	5.78453e-10	0.002445	1	0
MYO10	4651	broad.mit.edu	37	5	16672932	16672932	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:16672932C>T	uc003jft.3	-	37	5643	c.5175G>A	c.(5173-5175)GTG>GTA	p.V1725V	MYO10_uc011cnb.1_Silent_p.V354V|MYO10_uc011cnc.1_Silent_p.V604V|MYO10_uc011cnd.1_Silent_p.V1082V|MYO10_uc011cne.1_Silent_p.V1082V|MYO10_uc010itx.2_Silent_p.V1347V	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1725	FERM.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						GCTTCTCCACCACCTGGAAGA	0.567			NA											12	13					0	0	0.00245	0	0
CDH10	1008	broad.mit.edu	37	5	24535323	24535323	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:24535323G>T	uc003jgr.1	-	5	1044	c.712C>A	c.(712-714)CAG>AAG	p.Q238K	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	238	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TCTTTGGCCTGGATGACCACT	0.463			NA								HNSCC(23;0.051)			30	40					1.36615e-20	2.35362e-20	0.002836	1	0
TARS	6897	broad.mit.edu	37	5	33456123	33456123	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:33456123G>T	uc003jhy.2	+	7	1005	c.710G>T	c.(709-711)TGC>TTC	p.C237F	TARS_uc011cob.1_Missense_Mutation_p.C225F|TARS_uc010iup.1_Missense_Mutation_p.C178F|TARS_uc011coc.1_Missense_Mutation_p.C258F|TARS_uc003jhz.2_Missense_Mutation_p.C133F|TARS_uc011cod.1_Missense_Mutation_p.C116F	NM_152295	NP_689508	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	237					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			ovary(2)	2					L-Threonine(DB00156)	AAGTTCAAATGCCGGATATTG	0.294			NA											10	40					3.86212e-05	4.37828e-05	0.008291	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33576721	33576721	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:33576721G>T	uc003jia.1	-	19	3573	c.3410C>A	c.(3409-3411)ACT>AAT	p.T1137N	ADAMTS12_uc010iuq.1_Missense_Mutation_p.T1052N	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1137	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CACAGGCCAAGTGATAGGGTT	0.478			NA								HNSCC(64;0.19)			17	55					1.02788e-11	1.44747e-11	0.00499	1	0
EGFLAM	133584	broad.mit.edu	37	5	38451501	38451501	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:38451501C>A	uc003jlc.1	+	20	2976	c.2652C>A	c.(2650-2652)CCC>CCA	p.P884P	EGFLAM_uc003jlb.1_Silent_p.P876P|EGFLAM_uc003jle.1_Silent_p.P642P|EGFLAM_uc003jlf.1_Silent_p.P242P|EGFLAM_uc003jlg.1_Silent_p.P19P	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	884	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					GAGACAGCCCCATGAGACCCA	0.522	Colon(62;485 1295 3347 17454)		NA											57	70					7.77372e-23	1.37374e-22	0.00361	1	0
NNT	23530	broad.mit.edu	37	5	43645480	43645480	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:43645480G>T	uc003joe.2	+	10	1567	c.1312G>T	c.(1312-1314)GCT>TCT	p.A438S	NNT_uc003jof.2_Missense_Mutation_p.A438S	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	438	Mitochondrial matrix.				tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)	GATTTTCCCAGCTCCCACACC	0.373			NA											26	43					3.73988e-18	6.15629e-18	0.00632	1	0
HCN1	348980	broad.mit.edu	37	5	45262526	45262526	+	Missense_Mutation	SNP	C	C	T	rs141383188	byFrequency	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:45262526C>T	uc003jok.2	-	8	2195	c.2170G>A	c.(2170-2172)GCC>ACC	p.A724T		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	724	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						AGCTGGGAGGCGGTGGGGGAG	0.443			NA											12	26					0	0	0.001855	0	0
HCN1	348980	broad.mit.edu	37	5	45262657	45262657	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:45262657G>C	uc003jok.2	-	8	2064	c.2039C>G	c.(2038-2040)TCC>TGC	p.S680C		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	680	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GGGACTGGGGGAGTGCAGGTT	0.622			NA											38	25					0	0	0.004878	0	0
HCN1	348980	broad.mit.edu	37	5	45262811	45262811	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:45262811C>A	uc003jok.2	-	8	1910	c.1885G>T	c.(1885-1887)GAC>TAC	p.D629Y		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	629	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						ATCTCCCTGTCATGTTTCACA	0.448			NA											19	88					9.7654e-05	0.000109161	0.007413	1	0
CENPK	64105	broad.mit.edu	37	5	64850710	64850710	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:64850710C>A	uc003jts.2	-	3	237	c.25G>T	c.(25-27)GAT>TAT	p.D9Y	CENPK_uc003jtt.2_5'UTR|CENPK_uc003jtu.2_Missense_Mutation_p.D9Y	NM_022145	NP_071428	Q9BS16	CENPK_HUMAN	SoxLZ/Sox6 leucine zipper binding protein	9					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00466)		GTAGTACTATCCGGATCTAGA	0.279			NA											66	39					1.25742e-37	2.38579e-37	0.00361	1	0
IQGAP2	10788	broad.mit.edu	37	5	75893271	75893271	+	Silent	SNP	T	T	A	rs141398992	byFrequency	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:75893271T>A	uc003kek.2	+	10	1137	c.915T>A	c.(913-915)GCT>GCA	p.A305A		NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	305					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		CAGGGCAGGCTGCAGTGGACC	0.527			NA											17	12					0	0	0.00499	0	0
GPR98	84059	broad.mit.edu	37	5	90059178	90059178	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:90059178G>T	uc003kju.2	+	59	12273	c.12177G>T	c.(12175-12177)ACG>ACT	p.T4059T	GPR98_uc003kjt.2_Silent_p.T1765T	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4059	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGACATTGACGGTTGTCCGGT	0.418			NA											10	10					0.000442599	0.000483873	0.006214	1	0
CHD1	1105	broad.mit.edu	37	5	98236897	98236897	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:98236897G>C	uc003knf.2	-	5	728	c.580C>G	c.(580-582)CAA>GAA	p.Q194E		NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	194					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	TACCTATTTTGAGGTTTTCTG	0.328			NA											23	79					0	0	0.004656	0	0
LOC153328	153328	broad.mit.edu	37	5	135207338	135207338	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:135207338G>C	uc003laz.1	+	5	782	c.610G>C	c.(610-612)GAG>CAG	p.E204Q	LOC153328_uc003lba.2_Intron			Q6ZT89	S2548_HUMAN	RecName: Full=Putative mitochondrial carrier protein FLJ44862;	204	Helical; Name=4; (Potential).|Solcar 2.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTTCCTGAGTGAGTGGATCAC	0.662			NA											6	22					0	0	0.001168	0	0
IL9	3578	broad.mit.edu	37	5	135231498	135231498	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:135231498A>T	uc003lbb.1	-	1	19	c.8T>A	c.(7-9)CTG>CAG	p.L3Q		NM_000590	NP_000581	P15248	IL9_HUMAN	interleukin 9 precursor	3					immune response|inflammatory response|positive regulation of cell proliferation|positive regulation of interleukin-5 biosynthetic process	extracellular space	cytokine activity|cytokine receptor binding|growth factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GACCATGGCCAGAAGCATCTT	0.542			NA											13	5					0	0	0.004007	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202807	140202807	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:140202807G>C	uc003lhl.2	+	1	1447	c.1447G>C	c.(1447-1449)GCG>CCG	p.A483P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.A483P|PCDHA5_uc003lhj.1_Missense_Mutation_p.A483P	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	483	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACGCGGACGCGCAGGAGAA	0.667			NA											12	56					0	0	0.001855	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203561	140203561	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:140203561G>T	uc003lhl.2	+	1	2201	c.2201G>T	c.(2200-2202)GGC>GTC	p.G734V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.G734V|PCDHA5_uc003lhj.1_Missense_Mutation_p.G734V	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	734	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCACACGGGGCAAGCCCACT	0.662			NA											27	14					9.39395e-14	1.40812e-13	0.00632	1	0
PCDHA11	56138	broad.mit.edu	37	5	140250979	140250979	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:140250979C>A	uc003lia.2	+	1	3149	c.2291C>A	c.(2290-2292)CCT>CAT	p.P764H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.P764H	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	764	Cytoplasmic (Potential).|6 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGGGCCCACCTAAGACGGAC	0.637			NA											11	3					3.07112e-06	3.6122e-06	0.000978	1	0
PCDHB3	56132	broad.mit.edu	37	5	140480404	140480404	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:140480404G>A	uc003lio.2	+	1	171	c.171G>A	c.(169-171)GAG>GAA	p.E57E	uc003lin.2_Intron	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	57	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TAAGGGTAGAGGAACTGGCCG	0.502			NA											14	42					0	0	0.004007	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482553	140482553	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:140482553T>G	uc003lio.2	+	1	2320	c.2320T>G	c.(2320-2322)TTC>GTC	p.F774V	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	774	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TATCCCCAACTTCGTTGCTCA	0.517			NA											25	39					0	0	0.004289	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553499	140553499	+	Silent	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:140553499C>G	uc003lit.2	+	1	1257	c.1083C>G	c.(1081-1083)CCC>CCG	p.P361P		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	361	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAAACTCACCCGAGACAGTCG	0.473			NA											25	16					0	0	0.00333	0	0
PCDHB10	56126	broad.mit.edu	37	5	140572190	140572190	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:140572190G>T	uc003lix.2	+	1	239	c.65G>T	c.(64-66)GGA>GTA	p.G22V		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	22					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTTTTTTGGGGAGTGTCCTTG	0.468			NA											34	54					4.92203e-23	8.74084e-23	0.00623	1	0
PCDHB13	56123	broad.mit.edu	37	5	140595266	140595266	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:140595266T>C	uc003lja.1	+	1	1758	c.1571T>C	c.(1570-1572)CTG>CCG	p.L524P		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	524	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TACGAGGCCCTGCAGGGGTTC	0.692			NA											31	52					0	0	0.003755	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140712366	140712366	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:140712366G>T	uc003lji.1	+	1	2115	c.2115G>T	c.(2113-2115)CTG>CTT	p.L705L	PCDHGA1_uc011dan.1_Silent_p.L705L	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	705	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGTCTTCCTGGCCTTCGTCA	0.677			NA											15	73					1.5739e-10	2.13908e-10	0.004007	1	0
PCDHGA2	56113	broad.mit.edu	37	5	140718777	140718777	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:140718777G>T	uc003ljk.1	+	1	424	c.239G>T	c.(238-240)CGA>CTA	p.R80L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.R80L	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	80	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGAACCCGCGAAGCGGCAGC	0.572			NA											31	12					5.8336e-16	9.20356e-16	0.003271	1	0
PCDHGA4	56111	broad.mit.edu	37	5	140736964	140736964	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:140736964G>T	uc003ljq.1	+	1	2197	c.2197G>T	c.(2197-2199)GCA>TCA	p.A733S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGB2_uc003ljs.1_5'Flank|PCDHGA4_uc003ljp.1_Missense_Mutation_p.A733S|PCDHGB2_uc011dar.1_5'Flank	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	733	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCAGGTTGGCAGGTGTGCC	0.617			NA											22	23					7.41877e-09	9.63772e-09	0.001882	1	0
PCDHGA6	56109	broad.mit.edu	37	5	140753848	140753848	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:140753848C>A	uc003ljy.1	+	1	198	c.198C>A	c.(196-198)ATC>ATA	p.I66I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.I66I	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	66	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGTCCGCATCGTCTCCAGAG	0.592			NA											26	16					2.48779e-11	3.4594e-11	0.005443	1	0
PCDHGA6	56109	broad.mit.edu	37	5	140754055	140754056	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:140754055_140754056GG>TT	uc003ljy.1	+	1	405_406	c.405_406GG>TT	c.(403-408)AAGGAA>AATTAA	p.135_136KE>N*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Nonsense_Mutation_p.135_136KE>N*	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	135_136	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATTCTTAAAGGAAGAATTGGA	0.431			NA											16	21					0	0	0.004672	0	0
PCDHGC4	56098	broad.mit.edu	37	5	140864778	140864778	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:140864778G>C	uc003lky.1	+	1	38	c.38G>C	c.(37-39)CGG>CCG	p.R13P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc011dbb.1_Missense_Mutation_p.R13P	NM_018928	NP_061751	Q9Y5F7	PCDGL_HUMAN	protocadherin gamma subfamily C, 4 isoform 1	13					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAATCTGGCGGTGGGCTACC	0.572			NA											10	17					0	0	0.008291	0	0
POU4F3	5459	broad.mit.edu	37	5	145720006	145720006	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:145720006G>A	uc003loa.2	+	2	1105	c.1016G>A	c.(1015-1017)TGA>TAA	p.*339*		NM_002700	NP_002691	Q15319	PO4F3_HUMAN	POU class 4 homeobox 3	339					sensory perception of sound|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTGTCCACTGATTGCGGCAG	0.562			NA											4	17					0	0	0.000602	0	0
SPINK5	11005	broad.mit.edu	37	5	147470781	147470781	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:147470781A>C	uc003lox.2	+	8	729	c.656A>C	c.(655-657)AAT>ACT	p.N219T	SPINK5_uc010jgq.1_RNA|SPINK5_uc010jgs.1_Missense_Mutation_p.N191T|SPINK5_uc010jgr.2_Missense_Mutation_p.N200T|SPINK5_uc003low.2_Missense_Mutation_p.N219T|SPINK5_uc003loy.2_Missense_Mutation_p.N219T	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	219	Kazal-like 4.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTCGACGAAATGCTGAAAAG	0.333			NA											6	9					0	0	0.001984	0	0
GALNT10	55568	broad.mit.edu	37	5	153755919	153755919	+	Silent	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:153755919G>C	uc003lvh.2	+	5	783	c.651G>C	c.(649-651)CTG>CTC	p.L217L	GALNT10_uc003lvg.1_Silent_p.L217L|GALNT10_uc010jic.2_RNA|GALNT10_uc010jid.2_Intron	NM_198321	NP_938080	Q86SR1	GLT10_HUMAN	GalNAc transferase 10 isoform a	217	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			GGGAAGGGCTGATAAGGACCC	0.522			NA											12	40					0	0	0.000978	0	0
KIF4B	285643	broad.mit.edu	37	5	154394675	154394675	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:154394675G>A	uc010jih.1	+	1	1416	c.1256G>A	c.(1255-1257)AGG>AAG	p.R419K		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	419	Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ATGTTGGAGAGGATCATTTTG	0.478			NA											29	44					0	0	0.008361	0	0
SGCD	6444	broad.mit.edu	37	5	156074530	156074530	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:156074530C>A	uc003lwd.3	+	6	1032	c.556C>A	c.(556-558)CCC>ACC	p.P186T	SGCD_uc003lwb.2_Missense_Mutation_p.P187T|SGCD_uc003lwc.3_Missense_Mutation_p.P187T	NM_001128209	NP_001121681	Q92629	SGCD_HUMAN	delta-sarcoglycan isoform 3	186	Extracellular (Potential).				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma					0	Renal(175;0.00488)	Medulloblastoma(196;0.0378)|all_neural(177;0.106)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CAGGGCAGACCCCTTCAAAGA	0.413			NA											3	7					0.004672	0.00492473	0.004672	1	0
EBF1	1879	broad.mit.edu	37	5	158267100	158267100	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:158267100G>A	uc010jip.2	-	7	875	c.573C>T	c.(571-573)TTC>TTT	p.F191F	EBF1_uc011ddw.1_Silent_p.F58F|EBF1_uc011ddx.1_Silent_p.F191F|EBF1_uc003lxl.3_Silent_p.F168F	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	191					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TACATTTGAGGAAAAATTTCA	0.423			NA	T	HMGA2	lipoma								22	14					0	0	0.00278	0	0
GABRG2	2566	broad.mit.edu	37	5	161580243	161580244	+	Missense_Mutation	DNP	CG	CG	TC			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:161580243_161580244CG>TC	uc003lyz.3	+	9	1631_1632	c.1273_1274CG>TC	c.(1273-1275)CGA>TCA	p.R425S	GABRG2_uc010jjc.2_Missense_Mutation_p.R473S|GABRG2_uc003lyy.3_Missense_Mutation_p.R433S|GABRG2_uc011dej.1_Missense_Mutation_p.R330S	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	425	Cytoplasmic (Probable).|Interaction with GABARAP (Potential).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		TGAAGATTGTCGAACAGGAGCT	0.47			NA											48	31					0	0	0.004672	0	0
GABRG2	2566	broad.mit.edu	37	5	161580330	161580330	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:161580330T>G	uc003lyz.3	+	9	1718	c.1360T>G	c.(1360-1362)TGC>GGC	p.C454G	GABRG2_uc010jjc.2_Missense_Mutation_p.C502G|GABRG2_uc003lyy.3_Missense_Mutation_p.C462G|GABRG2_uc011dej.1_Missense_Mutation_p.C359G	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	454	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CACTGCCTTCTGCCTGTTTAA	0.458			NA											34	91					0	0	0.00623	0	0
NUDCD2	134492	broad.mit.edu	37	5	162886923	162886923	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:162886923C>G	uc003lze.2	-	1	221	c.134G>C	c.(133-135)TGC>TCC	p.C45S	HMMR_uc003lzh.2_5'Flank|HMMR_uc003lzf.2_5'Flank|HMMR_uc003lzg.2_5'Flank|HMMR_uc011dem.1_5'Flank	NM_145266	NP_660309	Q8WVJ2	NUDC2_HUMAN	NudC domain containing 2	45	CS.					intracellular					0	Renal(175;0.000281)	Medulloblastoma(196;0.0207)|all_neural(177;0.0966)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0981)|OV - Ovarian serous cystadenocarcinoma(192;0.183)|Epithelial(171;0.247)		CTGGAGGCCGCACTGGATATC	0.657			NA											10	55					0	0	0.008291	0	0
DOCK2	1794	broad.mit.edu	37	5	169135183	169135183	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:169135183G>T	uc003maf.2	+	15	1474	c.1394G>T	c.(1393-1395)TGC>TTC	p.C465F	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_5'UTR|DOCK2_uc010jjl.1_Intron	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	465	DHR-1.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AATGCAATTTGCGTGGGAGCA	0.463			NA											5	14					0.00116845	0.00125927	0.001168	1	0
DRD1	1812	broad.mit.edu	37	5	174869971	174869971	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:174869971G>T	uc003mcz.2	-	2	1077	c.132C>A	c.(130-132)GTC>GTA	p.V44V		NM_000794	NP_000785	P21728	DRD1_HUMAN	dopamine receptor D1	44	Helical; Name=1; (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			ovary(2)|skin(1)	3	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	CGGCAGCACAGACCAGCGTGT	0.577			NA											12	23					6.40141e-05	7.21159e-05	0.000978	1	0
CDHR2	54825	broad.mit.edu	37	5	176002986	176002986	+	Missense_Mutation	SNP	G	G	C	rs144851381		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:176002986G>C	uc003mem.1	+	12	1060	c.994G>C	c.(994-996)GAG>CAG	p.E332Q	CDHR2_uc003men.1_Missense_Mutation_p.E332Q	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	332	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						CTACGGGCAGGAGGCCAAGGT	0.577			NA											8	13					0	0	0.00308	0	0
UNC5A	90249	broad.mit.edu	37	5	176304276	176304276	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:176304276G>A	uc003mey.2	+	9	1654	c.1462G>A	c.(1462-1464)GTG>ATG	p.V488M		NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	488	ZU5.|Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCGGAAGACGTGAGGTGTGG	0.652			NA											21	18					0	0	0.00278	0	0
RNF130	55819	broad.mit.edu	37	5	179393827	179393827	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:179393827C>T	uc003mll.1	-	7	1536	c.1129G>A	c.(1129-1131)GAA>AAA	p.E377K	RNF130_uc003mlm.1_Missense_Mutation_p.E377K	NM_018434	NP_060904	Q86XS8	GOLI_HUMAN	ring finger protein 130 precursor	377	Cytoplasmic (Potential).				apoptosis	cytoplasm|integral to membrane|nucleus	ubiquitin-protein ligase activity|zinc ion binding			lung(2)|ovary(1)	3	all_cancers(89;5.49e-05)|all_epithelial(37;1.94e-05)|Renal(175;0.000159)|Lung NSC(126;0.00118)|all_lung(126;0.00212)	all_cancers(40;0.0294)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATGTTGATTTCTCCTGTTCTC	0.587	GBM(24;432 554 38471 39699 51728)		NA											11	6					0	0	0.000978	0	0
MYLK4	340156	broad.mit.edu	37	6	2679563	2679563	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:2679563C>G	uc003mty.3	-	9	1135	c.838G>C	c.(838-840)GTT>CTT	p.V280L	MYLK4_uc003mtx.3_5'UTR	NM_001012418	NP_001012418	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4	280	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(3)|ovary(1)	4	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				GGAAATGAAACAAAATCATAG	0.448			NA											22	281					0	0	0.002522	0	0
MYLK4	340156	broad.mit.edu	37	6	2679576	2679576	+	Silent	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:2679576C>G	uc003mty.3	-	9	1122	c.825G>C	c.(823-825)GTG>GTC	p.V275V	MYLK4_uc003mtx.3_5'UTR	NM_001012418	NP_001012418	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4	275	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(3)|ovary(1)	4	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				AATCATAGTTCACAACTTCAG	0.468			NA											21	302					0	0	0.00361	0	0
MYLK4	340156	broad.mit.edu	37	6	2679608	2679608	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:2679608C>T	uc003mty.3	-	9	1090	c.793G>A	c.(793-795)GGA>AGA	p.G265R	MYLK4_uc003mtx.3_5'UTR	NM_001012418	NP_001012418	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4	265	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(3)|ovary(1)	4	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				TCTGGGGTTCCAAAGTTCACC	0.438			NA											21	307					0	0	0.00361	0	0
MYLK4	340156	broad.mit.edu	37	6	2679643	2679643	+	Splice_Site	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:2679643C>G	uc003mty.3	-	9	1056	c.759_splice	c.e9-1	p.R253_splice	MYLK4_uc003mtx.3_5'UTR	NM_001012418	NP_001012418	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4								ATP binding|protein serine/threonine kinase activity			breast(3)|ovary(1)	4	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				GGGTTTGTATCTGCAATTTAA	0.413			NA											32	251					0	0	0.009718	0	0
MYLK4	340156	broad.mit.edu	37	6	2693048	2693048	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:2693048C>A	uc003mty.3	-	3	502	c.205G>T	c.(205-207)GTC>TTC	p.V69F		NM_001012418	NP_001012418	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4	69							ATP binding|protein serine/threonine kinase activity			breast(3)|ovary(1)	4	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				TTGCTTTTGACGGGCATCCTT	0.403			NA											11	31					2.62699e-14	3.97911e-14	0.003163	1	0
TUBB2B	347733	broad.mit.edu	37	6	3226399	3226399	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:3226399C>T	uc003mvg.2	-	3	462	c.271G>A	c.(271-273)GTG>ATG	p.V91M	uc003mvi.1_5'Flank|TUBB2B_uc010jnj.2_Intron|TUBB2B_uc010jnk.2_Missense_Mutation_p.V19M|TUBB2B_uc003mvh.2_Silent_p.S65S	NM_178012	NP_821080	Q9BVA1	TBB2B_HUMAN	tubulin, beta 2B	91					'de novo' posttranslational protein folding|microtubule-based movement|neuron migration|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			large_intestine(1)	1	Ovarian(93;0.0386)	all_hematologic(90;0.108)				TCACCAAACACGAAATTGTCT	0.532			NA											27	29					0	0	0.009535	0	0
RANBP9	10048	broad.mit.edu	37	6	13697085	13697085	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:13697085C>T	uc003nbb.2	-	2	674	c.615G>A	c.(613-615)ACG>ACA	p.T205T	RANBP9_uc003nba.2_5'UTR	NM_005493	NP_005484	Q96S59	RANB9_HUMAN	RAN binding protein 9	205	B30.2/SPRY.				axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			lung(1)|skin(1)	2	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			GTATTGGATGCGTGGCTCGAA	0.403			NA											18	411					0	0	0.010504	0	0
DEK	7913	broad.mit.edu	37	6	18236822	18236822	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:18236822G>C	uc003ncr.1	-	9	1101	c.908C>G	c.(907-909)TCT>TGT	p.S303C	DEK_uc011djf.1_Missense_Mutation_p.S269C|DEK_uc011djg.1_RNA	NM_003472	NP_003463	P35659	DEK_HUMAN	DEK oncogene isoform 1	303	Asp/Glu-rich (acidic).				chromatin modification|regulation of transcription from RNA polymerase II promoter|signal transduction|transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|histone binding			kidney(1)	1	Ovarian(93;0.00769)|Breast(50;0.0495)	all_hematologic(90;0.053)	OV - Ovarian serous cystadenocarcinoma(7;0.00291)|all cancers(50;0.031)|Epithelial(50;0.0332)			ACTATCCTCAGACTCACTTTC	0.259			NA	T	NUP214	AML								5	42					0	0	0.000602	0	0
LRRC16A	55604	broad.mit.edu	37	6	25581506	25581506	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:25581506G>T	uc011djw.1	+	31	3221	c.2845G>T	c.(2845-2847)GTA>TTA	p.V949L	LRRC16A_uc010jpx.2_Missense_Mutation_p.V949L|LRRC16A_uc010jpy.2_Missense_Mutation_p.V949L	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	949					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						GCTGGAAGAGGTACCAATTCA	0.443			NA											34	14					4.62619e-21	8.02764e-21	0.004289	1	0
HIST1H3D	8351	broad.mit.edu	37	6	26197189	26197189	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:26197189C>T	uc003ngv.2	-	2	687	c.290G>A	c.(289-291)TGC>TAC	p.C97Y	HIST1H2BF_uc003ngx.2_5'Flank	NM_003530	NP_003521	P68431	H31_HUMAN	histone cluster 1, H3d	97					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.196)				GTAGGCCTCGCAGGCCTCCTG	0.597	GBM(108;3816 4467)		NA											40	55					0	0	0.009718	0	0
HIST1H2BN	8341	broad.mit.edu	37	6	27806487	27806487	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:27806487G>A	uc003njv.2	+	1	48	c.48G>A	c.(46-48)AAG>AAA	p.K16K	HIST1H2AK_uc003njs.2_5'Flank|HIST1H2BN_uc003njt.1_RNA|HIST1H2BN_uc003nju.1_Silent_p.K16K	NM_003520	NP_003511	Q99877	H2B1N_HUMAN	histone cluster 1, H2bn	16					nucleosome assembly	nucleosome|nucleus	DNA binding				0						AAGGCTCCAAGAAGGCAGTGA	0.562			NA											30	149					0	0	0.007291	0	0
NKAPL	222698	broad.mit.edu	37	6	28227326	28227326	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:28227326C>A	uc003nkt.2	+	1	229	c.177C>A	c.(175-177)GAC>GAA	p.D59E	ZKSCAN4_uc011dlb.1_5'Flank	NM_001007531	NP_001007532	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	59										upper_aerodigestive_tract(1)|ovary(1)	2						GTGAGTTGGACGTGGGCGCTC	0.637			NA											33	52					5.91797e-21	1.02569e-20	0.002445	1	0
MAS1L	116511	broad.mit.edu	37	6	29455569	29455569	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:29455569C>T	uc011dlq.1	-	1	111	c.111G>A	c.(109-111)GAG>GAA	p.E37E		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	37	Extracellular (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						GGTTCTGTGCCTCCTGGTCAC	0.493	NSCLC(153;755 1987 3859 11251 32945)		NA											7	67					0	0	0.001984	0	0
PPP1R10	5514	broad.mit.edu	37	6	30570015	30570015	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:30570015C>A	uc003nqn.1	-	19	2963	c.2411G>T	c.(2410-2412)GGC>GTC	p.G804V	PPP1R10_uc010jsc.1_Missense_Mutation_p.G458V	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	804	Gly-rich.				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						GATGCCACCGCCAGGGCCTTC	0.687			NA											122	69					5.49952e-60	1.06162e-59	0.00361	1	0
DHX16	8449	broad.mit.edu	37	6	30638193	30638193	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:30638193C>A	uc003nqz.2	-	4	872	c.660G>T	c.(658-660)AAG>AAT	p.K220N	DHX16_uc011dmo.1_Missense_Mutation_p.K160N	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	220					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						TCACCATGGCCTTCCGGTCTT	0.517			NA											7	45					8.12818e-05	9.09297e-05	0.001984	1	0
MDC1	9656	broad.mit.edu	37	6	30673379	30673379	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:30673379G>C	uc003nrg.3	-	10	4021	c.3581C>G	c.(3580-3582)TCC>TGC	p.S1194C	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.S801C	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1194	Pro-rich.|Interaction with the PRKDC complex.			Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						CTTGACAGAGGATCTACTTTT	0.582			NA						Other_conserved_DNA_damage_response_genes					59	211					0	0	0.00361	0	0
TNXB	7148	broad.mit.edu	37	6	32024401	32024401	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:32024401C>A	uc003nzl.2	-	23	8307	c.8105G>T	c.(8104-8106)GGC>GTC	p.G2702V		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2762	Fibronectin type-III 19.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CACGCGCTGGCCACCGTGGAA	0.647			NA											19	17					2.98393e-07	3.65887e-07	0.00278	1	0
TNXB	7148	broad.mit.edu	37	6	32025888	32025888	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:32025888T>A	uc003nzl.2	-	22	7974	c.7772A>T	c.(7771-7773)TAC>TTC	p.Y2591F		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2651	Fibronectin type-III 18.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GTGGAGGCCGTACAGGTGCAT	0.677			NA											13	63					0	0	0.001855	0	0
NOTCH4	4855	broad.mit.edu	37	6	32168650	32168650	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:32168650G>T	uc003obb.2	-	23	4412	c.4273C>A	c.(4273-4275)CTG>ATG	p.L1425M	NOTCH4_uc003oba.2_Missense_Mutation_p.L88M|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1425	Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GGTCCAGGCAGCAGGGGCTCC	0.652			NA											5	22					3.59834e-05	4.10182e-05	0.001168	1	0
BTNL2	56244	broad.mit.edu	37	6	32363858	32363858	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:32363858C>T	uc003obg.1	-	5	1036	c.1036G>A	c.(1036-1038)GAT>AAT	p.D346N	BTNL2_uc010jty.1_Missense_Mutation_p.D69N|BTNL2_uc010jtz.1_RNA|BTNL2_uc010jua.1_Missense_Mutation_p.D136N	NM_019602	NP_062548	Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2	346	Extracellular (Potential).|Ig-like V-type 3.					integral to membrane				central_nervous_system(1)	1						TAGACATCATCTTTTTCAAAA	0.473			NA											13	95					0	0	0.00245	0	0
HLA-DQB1	3119	broad.mit.edu	37	6	32629998	32629998	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:32629998G>C	uc003obw.2	-	3	489	c.407C>G	c.(406-408)TCC>TGC	p.S136C	HLA-DQB1_uc010juc.1_Missense_Mutation_p.S91C|HLA-DQB1_uc003obv.2_Missense_Mutation_p.S136C|HLA-DQB1_uc011dqd.1_Missense_Mutation_p.S136C|HLA-DQB1_uc011dqe.1_Intron	NM_002123	NP_002114	P01920	DQB1_HUMAN	major histocompatibility complex, class II, DQ	136	Extracellular (Potential).|Beta-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTCTGTCCTGGATGGGGAGAT	0.532	Esophageal Squamous(151;720 1825 15000 40336 43415)		NA							Melanoma_Familial_Clustering_of|ACTH-independent_macronodular_adrenal_hyperplasia|T-cell_Lymphoma_(Cutaneous)__Familial_Clustering_of|Sj_gren_syndrome				19	59					0	0	0.001882	0	0
COL11A2	1302	broad.mit.edu	37	6	33139529	33139529	+	Silent	SNP	C	C	A	rs146093235	byFrequency	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:33139529C>A	uc003ocx.1	-	42	3339	c.3111G>T	c.(3109-3111)CCG>CCT	p.P1037P	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Silent_p.P951P|COL11A2_uc003ocz.1_Silent_p.P930P	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	1037	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						GGGGACCCTGCGGGCCTGGGC	0.657	Melanoma(1;90 116 3946 5341 17093)		NA											27	15					8.88839e-20	1.50612e-19	0.002096	1	0
LYPLA2P1	653639	broad.mit.edu	37	6	33333340	33333340	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:33333340C>A	uc003shx.2	-	1	800	c.666G>T	c.(664-666)CTG>CTT	p.L222L		NR_001444				SubName: Full=Lysophospholipase II; Flags: Fragment;												0						CAGGAGGCAGCAGCTTCTCAA	0.562			NA											18	7					2.37509e-13	3.5127e-13	0.010504	1	0
LEMD2	221496	broad.mit.edu	37	6	33744940	33744940	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:33744940C>A	uc011drm.1	-	7	1246	c.1233G>T	c.(1231-1233)ATG>ATT	p.M411I	LEMD2_uc010jvg.2_Missense_Mutation_p.M120I|LEMD2_uc011drl.1_Missense_Mutation_p.M109I|LEMD2_uc003ofe.2_Missense_Mutation_p.M109I	NM_181336	NP_851853	Q8NC56	LEMD2_HUMAN	LEM domain containing 2 isoform 1	411						integral to nuclear inner membrane				central_nervous_system(1)	1						CCATCTCATACATGGCTTGTT	0.498			NA											114	180					1.08021e-59	2.08243e-59	0.00361	1	0
UHRF1BP1	54887	broad.mit.edu	37	6	34789481	34789481	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:34789481G>A	uc003oju.3	+	2	330	c.96G>A	c.(94-96)GGG>GGA	p.G32G	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	32										ovary(3)	3						CCCTGAAAGGGGAGGGTCAGC	0.478			NA											48	51					0	0	0.00361	0	0
DEF6	50619	broad.mit.edu	37	6	35277470	35277470	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:35277470G>T	uc003okk.2	+	2	159	c.120G>T	c.(118-120)ACG>ACT	p.T40T	DEF6_uc010jvs.2_Silent_p.T40T|DEF6_uc010jvt.2_5'UTR	NM_022047	NP_071330	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog	40						cytoplasm|nucleus|plasma membrane					0						ACCTGTACACGGTCCTGCACA	0.587			NA											66	31					5.98616e-33	1.12104e-32	0.00361	1	0
C6orf222	389384	broad.mit.edu	37	6	36290124	36290124	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:36290124C>G	uc003oly.2	-	9	1745	c.1567G>C	c.(1567-1569)GAA>CAA	p.E523Q		NM_001010903	NP_001010903	P0C671	CF222_HUMAN	hypothetical protein LOC389384	523										skin(2)|ovary(1)|breast(1)	4						GGTGCCCCTTCTGGCGTGTGG	0.587			NA											76	58					0	0	0.00361	0	0
GLP1R	2740	broad.mit.edu	37	6	39046924	39046924	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:39046924G>C	uc003ooj.3	+	10	1051	c.991G>C	c.(991-993)GTG>CTG	p.V331L	GLP1R_uc003ooh.2_RNA|GLP1R_uc003ooi.2_RNA	NM_002062	NP_002053	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor precursor	331	Cytoplasmic (Potential).				activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			lung(3)|breast(1)|pancreas(1)	5					Exenatide(DB01276)|Glucagon recombinant(DB00040)	CATCTGCATCGTGGTATCCAA	0.562			NA											18	141					0	0	0.007413	0	0
SLC22A7	10864	broad.mit.edu	37	6	43271882	43271882	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:43271882T>C	uc003out.2	+	10	1591	c.1492T>C	c.(1492-1494)TAT>CAT	p.Y498H	SLC22A7_uc003ous.2_Missense_Mutation_p.Y496H	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	498	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			CAAGCTTACTTATGGGGGGAT	0.662			NA											11	245					0	0	0.001368	0	0
SLC22A7	10864	broad.mit.edu	37	6	43271936	43271936	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:43271936A>T	uc003out.2	+	10	1645	c.1546A>T	c.(1546-1548)AGG>TGG	p.R516W	SLC22A7_uc003ous.2_Missense_Mutation_p.R514W	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	516						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			GCCAGAGACGAGGCAGGCACA	0.602			NA											9	190					0	0	0.006214	0	0
TMEM63B	55362	broad.mit.edu	37	6	44115157	44115157	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:44115157A>T	uc003owr.2	+	12	971	c.907A>T	c.(907-909)AGC>TGC	p.S303C	TMEM63B_uc003owq.1_Missense_Mutation_p.S303C|TMEM63B_uc003ows.2_Missense_Mutation_p.S206C|TMEM63B_uc010jyz.2_RNA	NM_018426	NP_060896	Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	303						integral to membrane	nucleotide binding|protein binding			pancreas(2)|central_nervous_system(1)	3	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			AAACCTCCAGAGCAAGGAGAA	0.612			NA											147	29					0	0	0.00361	0	0
GPR115	221393	broad.mit.edu	37	6	47681720	47681720	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:47681720A>T	uc003oza.1	+	6	997	c.739A>T	c.(739-741)ATC>TTC	p.I247F	GPR115_uc003oyz.1_Missense_Mutation_p.I304F|GPR115_uc003ozb.1_Missense_Mutation_p.I245F	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	247	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						AGGGTTTCACATCAACCATAA	0.393	GBM(22;431 510 9010 26644 32828)		NA											13	74					0	0	0.001855	0	0
GPR115	221393	broad.mit.edu	37	6	47682757	47682757	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:47682757C>T	uc003oza.1	+	6	2034	c.1776C>T	c.(1774-1776)TCC>TCT	p.S592S	GPR115_uc003oyz.1_Silent_p.S649S|GPR115_uc003ozb.1_Silent_p.S590S	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	592	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						TTGGCAGTTCCAAGTCTCAGG	0.473	GBM(22;431 510 9010 26644 32828)		NA											12	116					0	0	0.001855	0	0
CRISP2	7180	broad.mit.edu	37	6	49666144	49666144	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:49666144G>T	uc003ozq.2	-	7	604	c.348C>A	c.(346-348)GAC>GAA	p.D116E	CRISP2_uc003ozl.2_Missense_Mutation_p.D116E|CRISP2_uc003ozn.2_Missense_Mutation_p.D116E|CRISP2_uc003ozr.2_Missense_Mutation_p.D116E|CRISP2_uc003ozo.2_Missense_Mutation_p.D116E|CRISP2_uc003ozm.2_Missense_Mutation_p.D116E|CRISP2_uc003ozp.2_Missense_Mutation_p.D116E	NM_001142408	NP_001135880	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2 precursor	116						extracellular space				skin(1)	1	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			CTAGGATCTCGTCATACCAGC	0.423			NA											47	47					7.88023e-25	1.42755e-24	0.00361	1	0
CRISP2	7180	broad.mit.edu	37	6	49667590	49667590	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:49667590C>A	uc003ozq.2	-	6	454	c.198G>T	c.(196-198)GAG>GAT	p.E66D	CRISP2_uc003ozl.2_Missense_Mutation_p.E66D|CRISP2_uc003ozn.2_Missense_Mutation_p.E66D|CRISP2_uc003ozr.2_Missense_Mutation_p.E66D|CRISP2_uc003ozo.2_Missense_Mutation_p.E66D|CRISP2_uc003ozm.2_Missense_Mutation_p.E66D|CRISP2_uc003ozp.2_Missense_Mutation_p.E66D	NM_001142408	NP_001135880	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2 precursor	66						extracellular space				skin(1)	1	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			TCGTTGTTACCTCTCTGCTCC	0.274			NA											13	28					3.27435e-08	4.14541e-08	0.00245	1	0
PKHD1	5314	broad.mit.edu	37	6	51927327	51927327	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:51927327G>T	uc003pah.1	-	14	1384	c.1108C>A	c.(1108-1110)CAA>AAA	p.Q370K	PKHD1_uc003pai.2_Missense_Mutation_p.Q370K	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	370	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CTGAAAGGTTGTCCTTCCTGT	0.488			NA											29	97					5.77227e-19	9.68989e-19	0.008361	1	0
IL17A	3605	broad.mit.edu	37	6	52054021	52054021	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:52054021C>A	uc003pak.1	+	3	444	c.399C>A	c.(397-399)TTC>TTA	p.F133L		NM_002190	NP_002181	Q16552	IL17_HUMAN	interleukin 17A precursor	133					apoptosis|cell-cell signaling|fibroblast activation|immune response|inflammatory response|positive regulation of interleukin-23 production|positive regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein glycosylation	extracellular space	cytokine activity				0	Lung NSC(77;0.116)					CCAACTCCTTCCGGCTGGAGA	0.597			NA											107	17					1.81606e-51	3.48702e-51	0.00361	1	0
GFRAL	389400	broad.mit.edu	37	6	55216119	55216119	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:55216119C>G	uc003pcm.1	+	5	525	c.439C>G	c.(439-441)CAG>GAG	p.Q147E		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	147	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CTGTAATGCACAGTTGGCCTC	0.458			NA											26	189					0	0	0.00632	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55360299	55360299	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:55360299T>G	uc003pcn.2	-	8	962	c.803A>C	c.(802-804)AAA>ACA	p.K268T	HMGCLL1_uc003pco.2_Missense_Mutation_p.K238T|HMGCLL1_uc010jzx.2_Missense_Mutation_p.K139T|HMGCLL1_uc011dxc.1_Missense_Mutation_p.K206T|HMGCLL1_uc011dxd.1_Missense_Mutation_p.K135T|HMGCLL1_uc011dxe.1_Intron	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	268							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			TGGGATTTCTTTCATCACACT	0.433	Ovarian(35;840 893 7837 15538 42887)		NA											50	39					0	0	0.00361	0	0
DST	667	broad.mit.edu	37	6	56397172	56397172	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:56397172C>A	uc003pdf.2	-	58	10749	c.10721G>T	c.(10720-10722)TGG>TTG	p.W3574L	DST_uc003pcz.3_Missense_Mutation_p.W3396L|DST_uc011dxj.1_Missense_Mutation_p.W3425L|DST_uc011dxk.1_Missense_Mutation_p.W3436L|DST_uc003pcy.3_Missense_Mutation_p.W3070L	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	5482	Spectrin 8.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CAATGCCTCCCATCTGCTATC	0.398			NA											24	17					9.57634e-11	1.30768e-10	0.00333	1	0
DST	667	broad.mit.edu	37	6	56397174	56397174	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:56397174T>A	uc003pdf.2	-	58	10747	c.10719A>T	c.(10717-10719)AGA>AGT	p.R3573S	DST_uc003pcz.3_Missense_Mutation_p.R3395S|DST_uc011dxj.1_Missense_Mutation_p.R3424S|DST_uc011dxk.1_Missense_Mutation_p.R3435S|DST_uc003pcy.3_Missense_Mutation_p.R3069S	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	5481	Spectrin 8.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ATGCCTCCCATCTGCTATCCA	0.408			NA											25	17					0	0	0.004656	0	0
DST	667	broad.mit.edu	37	6	56515773	56515773	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:56515773T>C	uc003pdf.2	-	11	1314	c.1286A>G	c.(1285-1287)TAT>TGT	p.Y429C	DST_uc003pcz.3_Missense_Mutation_p.Y251C|DST_uc011dxj.1_Missense_Mutation_p.Y280C|DST_uc011dxk.1_Missense_Mutation_p.Y291C|DST_uc011dxl.1_Missense_Mutation_p.Y280C|DST_uc003pde.2_Missense_Mutation_p.Y367C	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	251	CH 2.|Actin-binding.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AAATGCATCATAGAGAGATGA	0.368			NA											42	31					0	0	0.00361	0	0
PRIM2	5558	broad.mit.edu	37	6	57467183	57467183	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:57467183C>T	uc003pdx.2	+	12	1211	c.1124C>T	c.(1123-1125)CCA>CTA	p.P375L		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	375					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		CTATCCAATCCACCAAGCCAA	0.433			NA											14	104					0	0	0.003163	0	0
EYS	346007	broad.mit.edu	37	6	66063351	66063351	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:66063351C>A	uc011dxu.1	-	9	1997	c.1459G>T	c.(1459-1461)GGA>TGA	p.G487*	EYS_uc003peq.2_Nonsense_Mutation_p.G487*|EYS_uc003per.1_Nonsense_Mutation_p.G487*	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	487					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						AATTTGTTACCTGCAAATCCC	0.333			NA											10	51					2.17888e-05	2.49757e-05	0.006214	1	0
BAI3	577	broad.mit.edu	37	6	70071016	70071016	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:70071016G>T	uc003pev.3	+	29	4299	c.3851G>T	c.(3850-3852)TGT>TTT	p.C1284F	BAI3_uc010kak.2_Missense_Mutation_p.C1284F|BAI3_uc011dxx.1_Missense_Mutation_p.C490F	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1284	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				GTGTACTTATGTACGGATGAT	0.403			NA											12	43					1.36491e-13	2.03327e-13	0.001855	1	0
BAI3	577	broad.mit.edu	37	6	70071032	70071032	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:70071032G>A	uc003pev.3	+	29	4315	c.3867G>A	c.(3865-3867)TTG>TTA	p.L1289L	BAI3_uc010kak.2_Silent_p.L1289L|BAI3_uc011dxx.1_Silent_p.L495L	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1289	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				ATGATAATTTGAGAGGGGCTG	0.393			NA											20	33					0	0	0.010504	0	0
COL19A1	1310	broad.mit.edu	37	6	70873262	70873262	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:70873262G>T	uc003pfc.1	+	36	2491	c.2374G>T	c.(2374-2376)GGT>TGT	p.G792C	COL19A1_uc010kam.1_Missense_Mutation_p.G688C	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	792	Triple-helical region 4 (COL4).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						TGGACATCCTGGTCCCACAGG	0.438			NA											10	17					6.40141e-05	7.21159e-05	0.000978	1	0
COL12A1	1303	broad.mit.edu	37	6	75818746	75818746	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:75818746C>A	uc003phs.2	-	52	8254	c.8088G>T	c.(8086-8088)AGG>AGT	p.R2696S	COL12A1_uc003pht.2_Missense_Mutation_p.R1532S	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2696	TSP N-terminal.|Nonhelical region (NC3).				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						CGGCTGATTTCCTTTCCCCTT	0.323			NA											25	48					8.58068e-18	1.40287e-17	0.007291	1	0
TBX18	9096	broad.mit.edu	37	6	85447030	85447030	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:85447030G>T	uc003pkl.1	-	8	1197	c.1197C>A	c.(1195-1197)GCC>GCA	p.A399A	TBX18_uc010kbq.1_Intron	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	399					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		CCAGATGGAAGGCAGGAGAGG	0.582			NA											11	28					0.000151284	0.000168068	0.001855	1	0
NT5E	4907	broad.mit.edu	37	6	86203677	86203677	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:86203677A>C	uc003pko.3	+	9	2236	c.1680A>C	c.(1678-1680)TTA>TTC	p.L560F	NT5E_uc010kbr.2_Missense_Mutation_p.L510F	NM_002526	NP_002517	P21589	5NTD_HUMAN	5' nucleotidase, ecto precursor	560					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			ovary(3)|central_nervous_system(1)	4		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	GCTTTTCTTTAATATTTCTTT	0.353	Melanoma(140;797 1765 2035 2752 18208)		NA											12	25					0	0	0.001855	0	0
ZNF292	23036	broad.mit.edu	37	6	87968387	87968387	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:87968387G>C	uc003plm.3	+	8	5081	c.5040G>C	c.(5038-5040)CAG>CAC	p.Q1680H		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	1680					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		GTGAACCTCAGAGTTTGGTGG	0.333			NA											5	8					0	0	0.000602	0	0
SPACA1	81833	broad.mit.edu	37	6	88773917	88773917	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:88773917G>T	uc003pmn.2	+	6	828	c.711G>T	c.(709-711)TTG>TTT	p.L237F		NM_030960	NP_112222	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1 precursor	237	Helical; (Potential).					integral to membrane					0		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		TTTTCTTATTGATCTTCATAA	0.398			NA											19	41					5.35267e-07	6.49709e-07	0.007413	1	0
GABRR2	2570	broad.mit.edu	37	6	89975382	89975382	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:89975382C>A	uc003pnb.2	-	7	922	c.914G>T	c.(913-915)TGG>TTG	p.W305L	GABRR2_uc011dzx.1_Missense_Mutation_p.W181L	NM_002043	NP_002034	P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 2	305	Helical; (Potential).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity				0		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		GAAGGACACCCAGGACAGCAT	0.468			NA											16	32					0.000566183	0.000618512	0.00499	1	0
FBXL4	26235	broad.mit.edu	37	6	99328438	99328438	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:99328438A>C	uc003ppf.1	-	7	1738	c.1380T>G	c.(1378-1380)AGT>AGG	p.S460R	FBXL4_uc003ppg.1_Missense_Mutation_p.S460R|FBXL4_uc003pph.1_Missense_Mutation_p.S62R|FBXL4_uc010kcp.2_Intron	NM_012160	NP_036292	Q9UKA2	FBXL4_HUMAN	F-box and leucine-rich repeat protein 4	460	LRR 4.				ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex				skin(2)	2		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0413)		CCATGACACAACTGCCTAAAC	0.423			NA											10	25					0	0	0.008291	0	0
RPF2	84154	broad.mit.edu	37	6	111320934	111320934	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:111320934G>T	uc003pun.2	+	6	356	c.337G>T	c.(337-339)GTG>TTG	p.V113L	RPF2_uc003puo.2_Missense_Mutation_p.V50L	NM_032194	NP_115570	Q9H7B2	RPF2_HUMAN	brix domain containing 1	113	Brix.					nucleolus	protein binding			ovary(2)	2						TGACTACCATGTGCTGGATAT	0.333			NA											16	60					5.3912e-06	6.29483e-06	0.006122	1	0
TSPYL1	7259	broad.mit.edu	37	6	116600489	116600489	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:116600489C>T	uc003pwp.3	-	1	792	c.505G>A	c.(505-507)GAG>AAG	p.E169K	DSE_uc011ebf.1_Intron|DSE_uc003pwq.1_5'UTR|DSE_uc003pwr.2_5'Flank|DSE_uc003pws.2_5'Flank	NM_003309	NP_003300	Q9H0U9	TSYL1_HUMAN	TSPY-like 1	169					nucleosome assembly	nucleolus					0		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.0235)|OV - Ovarian serous cystadenocarcinoma(136;0.0469)|GBM - Glioblastoma multiforme(226;0.0503)|Epithelial(106;0.094)		CTCTCCCTCTCAGCCACGGCT	0.393			NA											10	52					0	0	0.000978	0	0
ROS1	6098	broad.mit.edu	37	6	117622204	117622204	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:117622204G>C	uc003pxp.1	-	42	6865	c.6666C>G	c.(6664-6666)TTC>TTG	p.F2222L	ROS1_uc011ebi.1_RNA	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	2222	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TGCTATTTAAGAAAAAATTTC	0.353			NA	T	GOPC|ROS1	glioblastoma|NSCLC								27	42					0	0	0.00632	0	0
MOXD1	26002	broad.mit.edu	37	6	132695848	132695848	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:132695848G>T	uc003qdf.2	-	2	432	c.333C>A	c.(331-333)GCC>GCA	p.A111A	MOXD1_uc003qde.2_Silent_p.A43A	NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1 isoform 2	111	Lumenal (Potential).|DOMON.				catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			ovary(1)	1	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		TATTTTCCATGGCATATTCTA	0.338			NA											10	58					2.17888e-05	2.49757e-05	0.006214	1	0
SLC35D3	340146	broad.mit.edu	37	6	137245529	137245529	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:137245529G>T	uc003qhe.2	+	2	1111	c.946G>T	c.(946-948)GCC>TCC	p.A316S		NM_001008783	NP_001008783	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	316					carbohydrate transport	integral to membrane				ovary(1)|central_nervous_system(1)	2	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)		GGACCTGGAGGCCCAGCCTCG	0.602			NA											13	13					9.31168e-06	1.08199e-05	0.001855	1	0
HIVEP2	3097	broad.mit.edu	37	6	143093749	143093749	+	Silent	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:143093749C>G	uc003qjd.2	-	5	2870	c.2127G>C	c.(2125-2127)ACG>ACC	p.T709T		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	709					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		AGATCATGGGCGTGTCCTCTT	0.522	Esophageal Squamous(107;843 1510 13293 16805 42198)		NA											36	40					0	0	0.003755	0	0
GRM1	2911	broad.mit.edu	37	6	146480550	146480550	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:146480550C>A	uc010khw.1	+	3	1237	c.767C>A	c.(766-768)GCC>GAC	p.A256D	GRM1_uc010khu.1_Missense_Mutation_p.A256D|GRM1_uc010khv.1_Missense_Mutation_p.A256D|GRM1_uc003qll.2_Missense_Mutation_p.A256D|GRM1_uc011edz.1_Missense_Mutation_p.A256D|GRM1_uc011eea.1_Missense_Mutation_p.A256D	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	256	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CTCTGTATCGCCCATTCTGAC	0.527			NA											17	24					2.94398e-08	3.74689e-08	0.007413	1	0
STXBP5	134957	broad.mit.edu	37	6	147680250	147680251	+	Missense_Mutation	DNP	GG	GG	TT	rs144076925		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:147680250_147680251GG>TT	uc003qlz.2	+	23	2497_2498	c.2336_2337GG>TT	c.(2335-2337)CGG>CTT	p.R779L	STXBP5_uc010khz.1_Missense_Mutation_p.R743L|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Missense_Mutation_p.R434L	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	779					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		AGCCGATCACGGAGTTCAAGTG	0.386			NA											13	23					0	0	0.004672	0	0
STXBP5	134957	broad.mit.edu	37	6	147684481	147684481	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:147684481G>A	uc003qlz.2	+	24	2717	c.2556G>A	c.(2554-2556)TTG>TTA	p.L852L	STXBP5_uc010khz.1_Silent_p.L816L|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Silent_p.L507L	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	852					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		GTACTATATTGAGGTTAAAAG	0.353			NA											7	24					0	0	0.00308	0	0
LATS1	9113	broad.mit.edu	37	6	150004668	150004668	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:150004668C>G	uc003qmu.1	-	4	2105	c.1557G>C	c.(1555-1557)TGG>TGC	p.W519C	LATS1_uc010kif.1_Missense_Mutation_p.W414C|LATS1_uc003qmv.1_Missense_Mutation_p.W519C|LATS1_uc003qmw.2_Missense_Mutation_p.W519C|LATS1_uc010kig.1_Missense_Mutation_p.W414C	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	519					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		GCTGTGGTATCCAAGAAGGGT	0.458			NA											11	56					0	0	0.000978	0	0
SYNE1	23345	broad.mit.edu	37	6	152949440	152949440	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:152949440C>A	uc010kiw.2	-	3	629	c.27G>T	c.(25-27)CGG>CGT	p.R9R	SYNE1_uc003qot.3_Silent_p.R9R|SYNE1_uc003qou.3_Silent_p.R9R|SYNE1_uc010kjb.1_Silent_p.R9R|SYNE1_uc003qpa.1_Silent_p.R9R	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	9	Actin-binding.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCCGAGGACACCGGGAGGCCC	0.517			NA								HNSCC(10;0.0054)			29	74					5.6714e-07	6.87819e-07	0.002096	1	0
NOX3	50508	broad.mit.edu	37	6	155728288	155728288	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:155728288T>A	uc003qqm.2	-	12	1659	c.1556A>T	c.(1555-1557)AAG>ATG	p.K519M		NM_015718	NP_056533	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	519	Cytoplasmic (Potential).						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		GGCAATCTGCTTGAACTCATT	0.488			NA											8	28					0	0	0.004482	0	0
NOX3	50508	broad.mit.edu	37	6	155743851	155743851	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:155743851G>C	uc003qqm.2	-	10	1388	c.1285C>G	c.(1285-1287)CAG>GAG	p.Q429E		NM_015718	NP_056533	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	429	Cytoplasmic (Potential).						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		AGTGGGGTCTGTGCCTCACTG	0.463			NA											31	36					0	0	0.009535	0	0
NOX3	50508	broad.mit.edu	37	6	155749951	155749951	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:155749951G>T	uc003qqm.2	-	9	1225	c.1122C>A	c.(1120-1122)CTC>CTA	p.L374L		NM_015718	NP_056533	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	374	Extracellular (Potential).|FAD-binding FR-type.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		AGGGCTCCTGGAGGGCCTGTC	0.532			NA											10	43					0.00829132	0.00870166	0.008291	1	0
IGF2R	3482	broad.mit.edu	37	6	160468351	160468351	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:160468351G>T	uc003qta.2	+	16	2360	c.2212G>T	c.(2212-2214)GGC>TGC	p.G738C		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	738	5.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		CGCGGGAGTGGGCTTCCCTGA	0.507			NA											7	9					0.000274275	0.000300993	0.004482	1	0
PLG	5340	broad.mit.edu	37	6	161135903	161135903	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:161135903T>A	uc003qtm.3	+	6	688	c.625T>A	c.(625-627)TGG>AGG	p.W209R		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	209	Kringle 2.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ATGCCAGGCCTGGGACTCTCA	0.473			NA											4	28					0	0	0.001168	0	0
PLG	5340	broad.mit.edu	37	6	161135906	161135906	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:161135906G>T	uc003qtm.3	+	6	691	c.628G>T	c.(628-630)GAC>TAC	p.D210Y		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	210	Kringle 2.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CCAGGCCTGGGACTCTCAGAG	0.468			NA											4	25					0.00116845	0.00125927	0.001168	1	0
PARK2	5071	broad.mit.edu	37	6	162206851	162206851	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:162206851C>G	uc003qtx.3	-	7	958	c.824G>C	c.(823-825)CGG>CCG	p.R275P	PARK2_uc003qtv.3_RNA|PARK2_uc010kkd.2_Missense_Mutation_p.R84P|PARK2_uc003qtw.3_Missense_Mutation_p.R84P|PARK2_uc003qty.3_Missense_Mutation_p.R247P|PARK2_uc003qtz.3_Missense_Mutation_p.R126P|PARK2_uc010kke.1_Missense_Mutation_p.R275P|PARK2_uc011egf.1_5'UTR	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	275	SYT11 binding 2.|RING-type 1; atypical.				aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		AACAAACTGCCGATCATTGAG	0.478			NA											6	11					0	0	0.001168	0	0
UNC93A	54346	broad.mit.edu	37	6	167717444	167717444	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:167717444C>A	uc003qvq.2	+	5	838	c.663C>A	c.(661-663)TTC>TTA	p.F221L	UNC93A_uc003qvr.2_Missense_Mutation_p.F179L	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	221	Helical; (Potential).					integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		TAGCTGCGTTCCTCCAACCCA	0.378			NA											17	30					6.94344e-10	9.19416e-10	0.006122	1	0
TCP10	6953	broad.mit.edu	37	6	167790080	167790080	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:167790080C>A	uc003qvv.1	-	5	742	c.530G>T	c.(529-531)AGG>ATG	p.R177M	TCP10_uc003qvu.2_Missense_Mutation_p.R177M|TCP10_uc003qvw.2_Missense_Mutation_p.R153M	NM_004610	NP_004601	Q12799	TCP10_HUMAN	t-complex 10	204						cytosol				breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		GGGAGTCGGCCTTCCAGTGGG	0.527			NA											22	55					1.75199e-13	2.59914e-13	0.007291	1	0
SNX8	29886	broad.mit.edu	37	7	2297015	2297015	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:2297015C>T	uc003slw.2	-	9	1162	c.1119G>A	c.(1117-1119)GAG>GAA	p.E373E		NM_013321	NP_037453	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	373					cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		CAATGCGGGACTCCAGCTGCT	0.697			NA											4	8					0	0	0.009096	0	0
RADIL	55698	broad.mit.edu	37	7	4856904	4856904	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:4856904T>A	uc003snj.1	-	7	1867	c.1694A>T	c.(1693-1695)TAC>TTC	p.Y565F	RADIL_uc003sng.1_RNA|RADIL_uc003sni.1_Missense_Mutation_p.Y70F|RADIL_uc011jwc.1_Missense_Mutation_p.Y325F|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	565	Dilute.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CTGGAAGGCGTACAGCACCAC	0.632			NA											35	12					0	0	0.002852	0	0
TMEM195	392636	broad.mit.edu	37	7	15470662	15470662	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:15470662T>A	uc003stb.1	-	4	651	c.481A>T	c.(481-483)AGA>TGA	p.R161*		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	161					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						ACAGACTGTCTCAGTGCTGTG	0.358			NA											10	59					0	0	0.008291	0	0
MEOX2	4223	broad.mit.edu	37	7	15725581	15725581	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:15725581G>T	uc003stc.2	-	1	728	c.447C>A	c.(445-447)TAC>TAA	p.Y149*	MEOX2_uc011jxw.1_Nonsense_Mutation_p.Y149*	NM_005924	NP_005915	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	149					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		CCTGGCGGCCGTAGTCCCCCG	0.706	Esophageal Squamous(140;197 1769 16409 18257 29929)		NA											51	38					4.86159e-25	8.82924e-25	0.00361	1	0
DNAH11	8701	broad.mit.edu	37	7	21901539	21901539	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:21901539C>A	uc003svc.2	+	70	11323	c.11292C>A	c.(11290-11292)ATC>ATA	p.I3764I		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3764					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AGGGACGCATCTCTATCCTGA	0.502			NA							Kartagener_syndrome				26	8					4.87955e-14	7.3295e-14	0.005443	1	0
SKAP2	8935	broad.mit.edu	37	7	26765118	26765118	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:26765118T>A	uc003syc.2	-	9	1018	c.725A>T	c.(724-726)CAT>CTT	p.H242L	SKAP2_uc011jzi.1_Missense_Mutation_p.H70L|SKAP2_uc011jzj.1_Missense_Mutation_p.H227L	NM_003930	NP_003921	O75563	SKAP2_HUMAN	src kinase associated phosphoprotein 2	242					B cell activation|cell junction assembly|protein complex assembly|signal transduction	cytosol|plasma membrane	SH3/SH2 adaptor activity			pancreas(1)	1						TGGTAGAGGATGATCAACATC	0.303			NA											33	25					0	0	0.003271	0	0
PKD1L1	168507	broad.mit.edu	37	7	47852827	47852827	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:47852827C>A	uc003tny.1	-	49	7238	c.7238G>T	c.(7237-7239)GGC>GTC	p.G2413V	C7orf69_uc003tnz.3_Intron|C7orf69_uc003toa.1_Intron|PKD1L1_uc003tob.2_Missense_Mutation_p.G140V	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2413	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						GTTCTCAGGGCCTCCAACTTC	0.547			NA											37	26					1.30998e-17	2.13205e-17	0.005524	1	0
ZNF680	340252	broad.mit.edu	37	7	63981790	63981790	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:63981790T>A	uc003tta.2	-	4	1515	c.1342A>T	c.(1342-1344)ACC>TCC	p.T448S	ZNF680_uc010kzr.2_Missense_Mutation_p.T375S	NM_178558	NP_848653	Q8NEM1	ZN680_HUMAN	zinc finger protein 680 isoform 1	448	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.118)|all_lung(88;0.243)				TTAGTAAGGGTTGAAAATAAA	0.363			NA											14	12					0	0	0.003163	0	0
KCTD7	154881	broad.mit.edu	37	7	66098289	66098289	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:66098289G>T	uc003tve.2	+	2	334	c.172G>T	c.(172-174)GGA>TGA	p.G58*	RABGEF1_uc003tvf.2_Intron|KCTD7_uc003tvd.3_Nonsense_Mutation_p.G58*	NM_153033	NP_694578	Q96MP8	KCTD7_HUMAN	potassium channel tetramerisation domain	58	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)	3						CCTTAACATCGGAGGGGCTCA	0.572			NA											17	13					2.48551e-13	3.65724e-13	0.00499	1	0
RABGEF1	27342	broad.mit.edu	37	7	66270381	66270381	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:66270381C>G	uc011kee.1	+	8	1281	c.1117C>G	c.(1117-1119)CTG>GTG	p.L373V	RABGEF1_uc003tvf.2_Missense_Mutation_p.L232V|RABGEF1_uc003tvg.2_Missense_Mutation_p.L167V|RABGEF1_uc010lag.2_Missense_Mutation_p.L359V|RABGEF1_uc003tvh.2_Missense_Mutation_p.L359V|RABGEF1_uc003tvi.2_Missense_Mutation_p.L193V	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	576	VPS9.				endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						TTTCACCAATCTGGTGAGTAA	0.512			NA											20	46					0	0	0.003954	0	0
POM121C	100101267	broad.mit.edu	37	7	75051125	75051125	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:75051125C>G	uc003udk.3	-	13	3295	c.2410G>C	c.(2410-2412)GGT>CGT	p.G804R		NM_001099415	NP_001092885	A8CG34	P121C_HUMAN	POM121 membrane glycoprotein (rat)-like	1046	Pore side (Potential).				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding				0						GTGGCTGCACCGAAGGAGAAG	0.647			NA											8	56					0	0	0.000978	0	0
POM121C	100101267	broad.mit.edu	37	7	75051152	75051152	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:75051152C>A	uc003udk.3	-	13	3268	c.2383G>T	c.(2383-2385)GGC>TGC	p.G795C		NM_001099415	NP_001092885	A8CG34	P121C_HUMAN	POM121 membrane glycoprotein (rat)-like	1037	Pore side (Potential).				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding				0						GTGGAGCCGCCAAAGGCGGGC	0.667			NA											31	31					1.26612e-14	1.94021e-14	0.003271	1	0
SEMA3D	223117	broad.mit.edu	37	7	84644484	84644484	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:84644484G>T	uc003uic.2	-	14	1634	c.1594C>A	c.(1594-1596)CAC>AAC	p.H532N	SEMA3D_uc010led.2_Missense_Mutation_p.H532N|SEMA3D_uc003uib.2_Missense_Mutation_p.H171N	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	532					cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						TCGCATCTGTGCAAGGAGAGC	0.468	Ovarian(63;442 1191 17318 29975 31528)		NA											58	74					1.00798e-23	1.80785e-23	0.00361	1	0
SEMA3D	223117	broad.mit.edu	37	7	84727122	84727122	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:84727122T>A	uc003uic.2	-	2	351	c.311A>T	c.(310-312)AAG>ATG	p.K104M	SEMA3D_uc010led.2_Missense_Mutation_p.K104M|SEMA3D_uc010lee.1_Missense_Mutation_p.K104M	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	104	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						TATACTGACCTTCTTAAAATT	0.353	Ovarian(63;442 1191 17318 29975 31528)		NA											68	91					0	0	0.00361	0	0
GRM3	2913	broad.mit.edu	37	7	86394822	86394822	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:86394822G>T	uc003uid.2	+	2	1460	c.361G>T	c.(361-363)GAT>TAT	p.D121Y	GRM3_uc010lef.2_Missense_Mutation_p.D119Y|GRM3_uc010leg.2_Intron|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	121	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GACAAAAGTGGATGAAGCTGA	0.438	GBM(52;969 1098 3139 52280)		NA											76	211					1.63007e-36	3.08879e-36	0.00361	1	0
ABCB1	5243	broad.mit.edu	37	7	87148649	87148649	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:87148649C>A	uc003uiz.1	-	24	3338	c.2920G>T	c.(2920-2922)GTT>TTT	p.V974F	ABCB1_uc011khc.1_Missense_Mutation_p.V910F	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	974	ABC transmembrane type-1 2.|Helical; (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TACAACAGAACATCCTCAAAG	0.239			NA											21	26					7.45023e-12	1.05429e-11	0.010504	1	0
C7orf63	79846	broad.mit.edu	37	7	89891302	89891302	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:89891302G>T	uc010lep.2	+	4	539	c.288G>T	c.(286-288)CTG>CTT	p.L96L	C7orf63_uc003ukf.2_RNA|C7orf63_uc003ukg.2_5'UTR|C7orf63_uc011khj.1_Silent_p.L96L|C7orf63_uc010leo.2_Silent_p.L96L	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	96							binding			ovary(1)	1						TTCTGAATCTGTGTTCAGGAA	0.249			NA											152	37					2.27665e-64	4.41254e-64	0.00361	1	0
HEPACAM2	253012	broad.mit.edu	37	7	92855759	92855759	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:92855759T>C	uc003umm.2	-	1	24	c.1A>G	c.(1-3)ATG>GTG	p.M1V	HEPACAM2_uc011khy.1_Missense_Mutation_p.M1V	NM_001039372	NP_001034461	A8MVW5	HECA2_HUMAN	HEPACAM family member 2 isoform 1	1						integral to membrane				ovary(3)|breast(1)|kidney(1)	5						TCCTGTCCCATGCATGCAGTG	0.493			NA											8	252					0	0	0.00308	0	0
CALCR	799	broad.mit.edu	37	7	93067545	93067545	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:93067545G>T	uc003umv.1	-	11	1203	c.942C>A	c.(940-942)ACC>ACA	p.T314T	CALCR_uc011kia.1_Silent_p.T94T|CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Silent_p.T280T|CALCR_uc003umw.2_Silent_p.T280T	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	296	Helical; Name=4; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	ACACGGCCCTGGTAATAGCAT	0.383			NA											313	40					3.91224e-161	7.64424e-161	0.00361	1	0
MUC17	140453	broad.mit.edu	37	7	100677982	100677982	+	Silent	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:100677982T>A	uc003uxp.1	+	3	3338	c.3285T>A	c.(3283-3285)ACT>ACA	p.T1095T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1095	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|16.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CAACCTCAACTTATAGTGAAG	0.507			NA											240	108					0	0	0.00361	0	0
MLL5	55904	broad.mit.edu	37	7	104753045	104753045	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:104753045C>A	uc003vcm.2	+	27	5376	c.4842C>A	c.(4840-4842)AAC>AAA	p.N1614K	MLL5_uc010ljc.2_Missense_Mutation_p.N1614K|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Missense_Mutation_p.N348K	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1614	Pro-rich.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						CCTCTCAGAACCCTACCATTC	0.547			NA											58	28					5.52965e-18	9.08172e-18	0.00361	1	0
NRCAM	4897	broad.mit.edu	37	7	107836209	107836209	+	Missense_Mutation	SNP	C	C	G	rs138146461	by1000genomes	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:107836209C>G	uc003vfb.2	-	15	1930	c.1459G>C	c.(1459-1461)GAG>CAG	p.E487Q	NRCAM_uc003vfc.2_Missense_Mutation_p.E481Q|NRCAM_uc011kmk.1_Missense_Mutation_p.E482Q|NRCAM_uc003vfd.2_Missense_Mutation_p.E463Q|NRCAM_uc003vfe.2_Missense_Mutation_p.E463Q	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	487	Ig-like 5.|Extracellular (Potential).			E -> Q (in Ref. 8; CAA04507).	angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						ACTTACCACTCGATGGTTGGG	0.418			NA											4	15					0	0	0.009096	0	0
SPAM1	6677	broad.mit.edu	37	7	123599874	123599874	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:123599874G>A	uc003vld.2	+	6	1783	c.1381G>A	c.(1381-1383)GAT>AAT	p.D461N	SPAM1_uc003vle.2_Missense_Mutation_p.D461N|SPAM1_uc011koa.1_Missense_Mutation_p.D117N|SPAM1_uc003vlf.3_Missense_Mutation_p.D461N|SPAM1_uc010lku.2_Missense_Mutation_p.D461N	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	461					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	GTGTATTGCTGATGGTGTCTG	0.388			NA											26	36					0	0	0.004656	0	0
PAX4	5078	broad.mit.edu	37	7	127251591	127251591	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:127251591C>G	uc010lld.1	-	8	1093	c.887G>C	c.(886-888)TGG>TCG	p.W296S	PAX4_uc003vmf.2_Missense_Mutation_p.W294S|PAX4_uc003vmg.1_Missense_Mutation_p.W296S	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	304	Transcription repression.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ATTCTTACCCCAGCAGGGCTT	0.577	Ovarian(113;737 1605 7858 27720 34092)		NA											23	59					0	0	0.005443	0	0
LOC407835	407835	broad.mit.edu	37	7	128766745	128766745	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:128766745C>A	uc003voo.2	+	1	421	c.174C>A	c.(172-174)ACC>ACA	p.T58T		NR_002144				SubName: Full=cDNA FLJ35806 fis, clone TESTI2005987, highly similar to Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2); SubName: Full=Mitogen-activated protein kinase kinase 2, isoform CRA_d;												0						CCTTTCTCACCCAGAAAGCCA	0.607			NA											25	22					2.14196e-07	2.64443e-07	0.007291	1	0
STRA8	346673	broad.mit.edu	37	7	134916754	134916754	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:134916754G>C	uc011kpx.1	+	1	24	c.24G>C	c.(22-24)AAG>AAC	p.K8N		NM_182489	NP_872295	Q7Z7C7	STRA8_HUMAN	STRA8	8					DNA replication|regulation of transcription, DNA-dependent	cytoplasm|nucleus					0						ATGTGGACAAGATCCTCTTTT	0.483			NA											52	27					0	0	0.00361	0	0
NUP205	23165	broad.mit.edu	37	7	135282896	135282896	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:135282896C>T	uc003vsw.2	+	15	2246	c.2215C>T	c.(2215-2217)CTT>TTT	p.L739F		NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	739					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						TTTGCAGTTCCTTAGAGACTC	0.458			NA											112	62					0	0	0.00361	0	0
CHRM2	1129	broad.mit.edu	37	7	136700567	136700567	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:136700567A>G	uc003vtf.1	+	4	1578	c.955A>G	c.(955-957)AAC>GAC	p.N319D	CHRM2_uc003vtg.1_Missense_Mutation_p.N319D|CHRM2_uc003vtj.1_Missense_Mutation_p.N319D|CHRM2_uc003vtk.1_Missense_Mutation_p.N319D|CHRM2_uc003vtl.1_Missense_Mutation_p.N319D|CHRM2_uc003vtm.1_Missense_Mutation_p.N319D|CHRM2_uc003vti.1_Missense_Mutation_p.N319D|CHRM2_uc003vto.1_Missense_Mutation_p.N319D|CHRM2_uc003vtn.1_Missense_Mutation_p.N319D|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	319	Cytoplasmic (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	CAAAGATGAGAACTCTAAGCA	0.468			NA											20	45					0	0	0.008871	0	0
SVOPL	136306	broad.mit.edu	37	7	138312951	138312951	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:138312951G>T	uc011kqh.1	-	10	1021	c.1021C>A	c.(1021-1023)CCC>ACC	p.P341T	SVOPL_uc003vue.2_Missense_Mutation_p.P189T	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	341						integral to membrane	transmembrane transporter activity				0						TAGTCAGAGGGTGCAAACATG	0.562			NA											32	18					1.21669e-08	1.57634e-08	0.003271	1	0
OR9A4	130075	broad.mit.edu	37	7	141618956	141618956	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:141618956T>G	uc003vwu.1	+	1	281	c.281T>G	c.(280-282)TTG>TGG	p.L94W		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.0171)					ACAATATATTTGTCTGCCTGT	0.527			NA											10	87					0	0	0.001368	0	0
TPK1	27010	broad.mit.edu	37	7	144380019	144380019	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:144380019G>T	uc003weq.2	-	4	271	c.168C>A	c.(166-168)ACC>ACA	p.T56T	TPK1_uc003weo.2_Missense_Mutation_p.P11Q|TPK1_uc003wep.2_RNA|TPK1_uc003wer.2_Silent_p.T56T|TPK1_uc003wes.2_RNA	NM_022445	NP_071890	Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1 isoform a	56					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			ovary(2)	2					Thiamine(DB00152)	TCTCTCCTTCGGTGATATCAT	0.388	Ovarian(45;88 1034 2073 5829 28455)		NA											37	83					6.53348e-20	1.11494e-19	0.003755	1	0
PDIA4	9601	broad.mit.edu	37	7	148701251	148701251	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:148701251C>G	uc003wff.2	-	10	1855	c.1573G>C	c.(1573-1575)GGA>CGA	p.G525R		NM_004911	NP_004902	P13667	PDIA4_HUMAN	protein disulfide isomerase A4 precursor	525	Thioredoxin 3.				cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			lung(5)|ovary(1)	6	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			TTGACGGGTCCCTTGTTGTTC	0.567			NA											75	33					0	0	0.00361	0	0
SLC4A2	6522	broad.mit.edu	37	7	150767073	150767073	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:150767073G>T	uc003wit.3	+	9	1443	c.1187G>T	c.(1186-1188)GGA>GTA	p.G396V	SLC4A2_uc011kve.1_Missense_Mutation_p.G387V|SLC4A2_uc003wiu.3_Missense_Mutation_p.G382V|SLC4A2_uc003wiv.3_5'Flank	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	396	Cytoplasmic (Potential).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACCCTGCCCGGAGTGGCCCAC	0.607			NA											22	11					7.41877e-09	9.63772e-09	0.001882	1	0
MLL3	58508	broad.mit.edu	37	7	151874875	151874875	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:151874875C>G	uc003wla.2	-	38	7882	c.7663G>C	c.(7663-7665)GGC>CGC	p.G2555R	MLL3_uc003wkz.2_Missense_Mutation_p.G1616R|MLL3_uc003wky.2_Missense_Mutation_p.G64R	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2555	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TATGCTTGGCCCAGTATGTTG	0.473	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								21	41					0	0	0.008871	0	0
HTR5A	3361	broad.mit.edu	37	7	154875913	154875913	+	Missense_Mutation	SNP	G	G	A	rs150067714	byFrequency	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:154875913G>A	uc003wlu.1	+	2	854	c.790G>A	c.(790-792)GCC>ACC	p.A264T		NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	264	Cytoplasmic (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		GGTCCGCCACGCCACCGTCAC	0.602			NA											14	28					0	0	0.004007	0	0
RP1L1	94137	broad.mit.edu	37	8	10464791	10464791	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:10464791G>T	uc003wtc.2	-	4	7046	c.6817C>A	c.(6817-6819)CCT>ACT	p.P2273T		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	2273					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CTGTCCTCAGGGACTGGGCTG	0.587			NA											53	59					4.96213e-28	9.16184e-28	0.00361	1	0
RP1L1	94137	broad.mit.edu	37	8	10469162	10469162	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:10469162C>A	uc003wtc.2	-	4	2675	c.2446G>T	c.(2446-2448)GGG>TGG	p.G816W		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	816					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CCCACCGCCCCTTGCTCAGGC	0.692			NA											7	16					2.0095e-06	2.38297e-06	0.001984	1	0
RP1L1	94137	broad.mit.edu	37	8	10469891	10469891	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:10469891C>A	uc003wtc.2	-	4	1946	c.1717G>T	c.(1717-1719)GAC>TAC	p.D573Y		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	573					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GAAGCGGGGTCGCCTCCCTCG	0.662			NA											29	45					1.06801e-11	1.50105e-11	0.009535	1	0
GATA4	2626	broad.mit.edu	37	8	11615981	11615981	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:11615981G>T	uc003wuc.2	+	7	1880	c.1326G>T	c.(1324-1326)GCG>GCT	p.A442A	GATA4_uc003wub.1_Silent_p.A236A|GATA4_uc011kxc.1_Silent_p.A443A|uc003wud.1_5'Flank	NM_002052	NP_002043	P43694	GATA4_HUMAN	GATA binding protein 4	442					atrial septum primum morphogenesis|atrial septum secundum morphogenesis|blood coagulation|cardiac right ventricle morphogenesis|cell-cell signaling|embryonic foregut morphogenesis|embryonic heart tube anterior/posterior pattern formation|endocardial cushion development|endoderm development|heart looping|intestinal epithelial cell differentiation|male gonad development|positive regulation of angiogenesis|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|response to drug|transcription from RNA polymerase II promoter|ventricular septum development	nucleoplasm	activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(15;0.0839)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.199)		TAATCACTGCGTAATCTTCCC	0.602			NA											9	34					0.000978159	0.00106133	0.000978	1	0
DLC1	10395	broad.mit.edu	37	8	12956865	12956865	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:12956865C>A	uc003wwm.2	-	9	3425	c.2981G>T	c.(2980-2982)AGG>ATG	p.R994M	DLC1_uc003wwk.1_Missense_Mutation_p.R557M|DLC1_uc003wwl.1_Missense_Mutation_p.R591M|DLC1_uc011kxx.1_Missense_Mutation_p.R483M	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	994					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						CCTGTTGGACCTGGTTAGGGA	0.562			NA											12	19					4.84862e-15	7.46977e-15	0.000978	1	0
SLC18A1	6570	broad.mit.edu	37	8	20036811	20036811	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:20036811C>A	uc011kyq.1	-	4	780	c.309G>T	c.(307-309)ATG>ATT	p.M103I	SLC18A1_uc003wzm.2_Missense_Mutation_p.M103I|SLC18A1_uc011kyr.1_Missense_Mutation_p.M103I|SLC18A1_uc003wzn.2_Missense_Mutation_p.M103I|SLC18A1_uc010ltf.2_RNA|SLC18A1_uc003wzo.2_Missense_Mutation_p.M103I	NM_001135691	NP_001129163	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine),	103	Lumenal, vesicle (Potential).				neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			ovary(2)	2				Colorectal(74;0.0747)		CAGTGTCATTCATCCATGCTA	0.498			NA											12	31					0.000978159	0.00106133	0.000978	1	0
XPO7	23039	broad.mit.edu	37	8	21835336	21835336	+	Silent	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:21835336T>A	uc003xaa.3	+	8	921	c.819T>A	c.(817-819)CCT>CCA	p.P273P	XPO7_uc010lti.2_Silent_p.P282P|XPO7_uc010ltk.2_Silent_p.P274P	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	273				Missing (in Ref. 3; BAA34465).	mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		ATTCCATCCCTCCTTCATTTT	0.373			NA											6	22					0	0	0.001168	0	0
RHOBTB2	23221	broad.mit.edu	37	8	22864676	22864676	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:22864676G>T	uc003xcq.2	+	5	1455	c.918G>T	c.(916-918)GGG>GGT	p.G306G	RHOBTB2_uc003xcp.2_Silent_p.G328G|RHOBTB2_uc011kzp.1_Silent_p.G313G|uc003xcr.2_RNA	NM_015178	NP_055993	Q9BYZ6	RHBT2_HUMAN	Rho-related BTB domain containing 2 isoform 3	306	BTB 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			ovary(1)|lung(1)	2		Prostate(55;0.0513)|Breast(100;0.214)		Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		GGGAGCTGGGGGGCCCCTCGG	0.542			NA											13	31					1.52009e-12	2.18978e-12	0.003163	1	0
DOCK5	80005	broad.mit.edu	37	8	25226140	25226140	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:25226140A>T	uc003xeg.2	+	33	3474	c.3337A>T	c.(3337-3339)ACT>TCT	p.T1113S	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Missense_Mutation_p.T827S|DOCK5_uc003xei.2_Missense_Mutation_p.T683S|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1113						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		TCTGGAGGTCACTCTGACCCC	0.403	Pancreas(145;34 1887 3271 10937 30165)		NA											9	32					0	0	0.004482	0	0
ADRA1A	148	broad.mit.edu	37	8	26627890	26627890	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:26627890C>A	uc003xfh.1	-	2	1613	c.1177G>T	c.(1177-1179)GGC>TGC	p.G393C	ADRA1A_uc003xfc.1_Missense_Mutation_p.G393C|ADRA1A_uc010lul.1_Intron|ADRA1A_uc003xfd.1_Intron|ADRA1A_uc003xfe.1_Missense_Mutation_p.G393C|ADRA1A_uc010lum.1_Intron|ADRA1A_uc003xff.1_Intron|ADRA1A_uc003xfg.1_Missense_Mutation_p.G393C	NM_000680	NP_000671	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 1	393	Cytoplasmic (By similarity).				activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	TCACAAACGCCATCCGTCTTG	0.562			NA											13	75					1.61879e-10	2.19183e-10	0.001368	1	0
HMBOX1	79618	broad.mit.edu	37	8	28827628	28827628	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:28827628A>T	uc003xhd.3	+	3	434	c.92A>T	c.(91-93)CAG>CTG	p.Q31L	HMBOX1_uc010lvd.2_Missense_Mutation_p.Q31L|HMBOX1_uc003xhc.3_Missense_Mutation_p.Q31L|HMBOX1_uc010lve.2_RNA|HMBOX1_uc003xhe.2_Missense_Mutation_p.Q31L|HMBOX1_uc011lay.1_Missense_Mutation_p.Q31L|HMBOX1_uc003xhf.2_Missense_Mutation_p.Q19L|HMBOX1_uc003xhg.2_Missense_Mutation_p.Q19L	NM_001135726	NP_001129198	Q6NT76	HMBX1_HUMAN	homeobox containing 1	31					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Ovarian(32;0.0192)		KIRC - Kidney renal clear cell carcinoma(542;0.135)|Kidney(114;0.161)		GATCTGCTTCAGCGACTTCGG	0.393			NA											26	31					0	0	0.004656	0	0
TMEM66	51669	broad.mit.edu	37	8	29924381	29924381	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:29924381C>A	uc003xhs.2	-	4	938	c.754G>T	c.(754-756)GGA>TGA	p.G252*	TMEM66_uc003xht.2_Nonsense_Mutation_p.G252*|TMEM66_uc003xhu.2_Nonsense_Mutation_p.G216*|TMEM66_uc003xhv.2_Nonsense_Mutation_p.G80*	NM_016127	NP_057211	Q96BY9	TMM66_HUMAN	transmembrane protein 66 precursor	252						integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(542;0.0993)|Kidney(114;0.119)		CCTTGTTGTCCTGTAAAAGCA	0.398			NA											32	55					1.22384e-17	1.99635e-17	0.002836	1	0
UNC5D	137970	broad.mit.edu	37	8	35453098	35453098	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:35453098C>A	uc003xjr.1	+	4	821	c.493C>A	c.(493-495)CCA>ACA	p.P165T	UNC5D_uc003xjs.1_Missense_Mutation_p.P160T	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	165	Extracellular (Potential).|Ig-like C2-type.				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TGAACAAGACCCACAAGGAAG	0.463			NA											22	53					4.4004e-07	5.35475e-07	0.00333	1	0
UNC5D	137970	broad.mit.edu	37	8	35583812	35583812	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:35583812A>C	uc003xjr.1	+	10	1774	c.1446A>C	c.(1444-1446)AAA>AAC	p.K482N	UNC5D_uc003xjs.1_Missense_Mutation_p.K477N|UNC5D_uc003xju.1_Missense_Mutation_p.K58N|UNC5D_uc003xjt.1_Missense_Mutation_p.K240N	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	482	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CGGACATCAAAGTGAAAGTCC	0.522			NA											5	15					0	0	0.000602	0	0
KCNU1	157855	broad.mit.edu	37	8	36691150	36691150	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:36691150G>T	uc010lvw.2	+	11	1272	c.1185G>T	c.(1183-1185)ATG>ATT	p.M395I	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	395	RCK N-terminal.|Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		GATCTGCAATGAAGTGGGAGG	0.393			NA											4	22					0.00909568	0.00949057	0.009096	1	0
GPR124	25960	broad.mit.edu	37	8	37693152	37693152	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:37693152C>A	uc003xkj.2	+	13	2277	c.1914C>A	c.(1912-1914)CCC>CCA	p.P638P	GPR124_uc010lvy.2_Intron	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	638	Extracellular (Potential).				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			CCCCGGTGCCCCCAGACTGCA	0.667			NA											50	70					2.01807e-28	3.73084e-28	0.00361	1	0
GPR124	25960	broad.mit.edu	37	8	37698729	37698729	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:37698729C>A	uc003xkj.2	+	19	3236	c.2873C>A	c.(2872-2874)CCC>CAC	p.P958H	GPR124_uc010lvy.2_Missense_Mutation_p.P741H	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	958	Cytoplasmic (Potential).				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			GCACAGAACCCCAAGGCGGGC	0.637			NA											12	27					1.08611e-07	1.35482e-07	0.000978	1	0
FNTA	2339	broad.mit.edu	37	8	42940002	42940002	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:42940002A>T	uc003xps.2	+	8	1043	c.995A>T	c.(994-996)GAC>GTC	p.D332V	FNTA_uc003xpt.2_Missense_Mutation_p.D241V|FNTA_uc003xpu.2_Missense_Mutation_p.D265V|FNTA_uc003xpv.2_RNA	NM_002027	NP_002018	P49354	FNTA_HUMAN	farnesyltransferase, CAAX box, alpha isoform a	332					cellular component disassembly involved in apoptosis|positive regulation of deacetylase activity|positive regulation of tubulin deacetylation|protein farnesylation|protein geranylgeranylation|transforming growth factor beta receptor signaling pathway	cytosol|microtubule associated complex	alpha-tubulin binding|CAAX-protein geranylgeranyltransferase activity|microtubule binding|protein farnesyltransferase activity			ovary(1)	1	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			AATAAGGAAGACATTCTTAAT	0.393			NA											49	55					0	0	0.00361	0	0
PRKDC	5591	broad.mit.edu	37	8	48772236	48772236	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:48772236C>T	uc003xqi.2	-	47	6200	c.6143G>A	c.(6142-6144)GGA>GAA	p.G2048E	PRKDC_uc003xqj.2_Missense_Mutation_p.G2048E|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2048					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GCTCTGAACTCCGGTTGAGAA	0.423	Esophageal Squamous(79;1091 1253 12329 31680 40677)		NA						NHEJ					42	96					0	0	0.009718	0	0
SNTG1	54212	broad.mit.edu	37	8	51569499	51569499	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:51569499G>T	uc010lxy.1	+	15	1251	c.880G>T	c.(880-882)GAG>TAG	p.E294*	SNTG1_uc003xqs.1_Nonsense_Mutation_p.E294*|SNTG1_uc010lxz.1_Nonsense_Mutation_p.E294*|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	294	PH.				cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				TGAAGCCCGGGAGCAAGACCC	0.443			NA											37	168					1.47197e-15	2.29468e-15	0.007835	1	0
PCMTD1	115294	broad.mit.edu	37	8	52733193	52733193	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:52733193C>A	uc003xqx.3	-	6	1133	c.792G>T	c.(790-792)CAG>CAT	p.Q264H	PCMTD1_uc011ldm.1_Missense_Mutation_p.Q134H|PCMTD1_uc003xqw.3_Missense_Mutation_p.Q264H|PCMTD1_uc011ldn.1_Missense_Mutation_p.Q76H|PCMTD1_uc010lya.2_Missense_Mutation_p.Q188H	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate)	264						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0		Lung NSC(129;0.0795)|all_lung(136;0.144)				TCCCCTTGGCCTGCATCTCAT	0.408			NA											13	134					2.61681e-11	3.63531e-11	0.00245	1	0
PCMTD1	115294	broad.mit.edu	37	8	52733210	52733210	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:52733210T>G	uc003xqx.3	-	6	1116	c.775A>C	c.(775-777)ATA>CTA	p.I259L	PCMTD1_uc011ldm.1_Missense_Mutation_p.I129L|PCMTD1_uc003xqw.3_Missense_Mutation_p.I259L|PCMTD1_uc011ldn.1_Missense_Mutation_p.I71L|PCMTD1_uc010lya.2_Missense_Mutation_p.I183L	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate)	259						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0		Lung NSC(129;0.0795)|all_lung(136;0.144)				TCATCATTTATGAAATTTCTA	0.403			NA											9	112					0	0	0.001368	0	0
RP1	6101	broad.mit.edu	37	8	55539392	55539392	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:55539392G>C	uc003xsd.1	+	4	3098	c.2950G>C	c.(2950-2952)GAT>CAT	p.D984H	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	984			D -> G (in RP1).		axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTTGACAGGAGATAATCTATG	0.348	Colon(91;1014 1389 7634 14542 40420)		NA											7	226					0	0	0.001984	0	0
TMEM68	137695	broad.mit.edu	37	8	56675394	56675394	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:56675394T>G	uc003xsg.1	-	1	194	c.125A>C	c.(124-126)AAC>ACC	p.N42T	TMEM68_uc003xsh.1_Missense_Mutation_p.N42T|TMEM68_uc003xsi.1_Missense_Mutation_p.N42T	NM_152417	NP_689630	Q96MH6	TMM68_HUMAN	transmembrane protein 68	42						integral to membrane	acyltransferase activity			skin(1)	1			Epithelial(17;0.000361)|all cancers(17;0.00326)			CAAGAGATAGTTTGCAAAATT	0.348			NA											62	189					0	0	0.00361	0	0
TMEM68	137695	broad.mit.edu	37	8	56675424	56675424	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:56675424T>G	uc003xsg.1	-	1	164	c.95A>C	c.(94-96)GAG>GCG	p.E32A	TMEM68_uc003xsh.1_Missense_Mutation_p.E32A|TMEM68_uc003xsi.1_Missense_Mutation_p.E32A	NM_152417	NP_689630	Q96MH6	TMM68_HUMAN	transmembrane protein 68	32						integral to membrane	acyltransferase activity			skin(1)	1			Epithelial(17;0.000361)|all cancers(17;0.00326)			CTCCAACTGCTCCACACCAAA	0.358			NA											54	220					0	0	0.00361	0	0
TMEM68	137695	broad.mit.edu	37	8	56675442	56675442	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:56675442T>C	uc003xsg.1	-	1	146	c.77A>G	c.(76-78)GAA>GGA	p.E26G	TMEM68_uc003xsh.1_Missense_Mutation_p.E26G|TMEM68_uc003xsi.1_Missense_Mutation_p.E26G	NM_152417	NP_689630	Q96MH6	TMM68_HUMAN	transmembrane protein 68	26						integral to membrane	acyltransferase activity			skin(1)	1			Epithelial(17;0.000361)|all cancers(17;0.00326)			AAACCATTCTTCGAGTATGTG	0.358			NA											68	216					0	0	0.00361	0	0
CSPP1	79848	broad.mit.edu	37	8	68049768	68049768	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:68049768G>T	uc003xxi.2	+	17	2026	c.1995G>T	c.(1993-1995)ATG>ATT	p.M665I	CSPP1_uc003xxg.1_Missense_Mutation_p.M657I|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.M630I|CSPP1_uc003xxk.2_Missense_Mutation_p.M336I	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	665	Potential.					centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AAGCTGAAATGAGAACATATA	0.353			NA											11	11					0.000151284	0.000168068	0.001855	1	0
NCOA2	10499	broad.mit.edu	37	8	71039095	71039095	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:71039095C>T	uc003xyn.1	-	19	4031	c.3869G>A	c.(3868-3870)CGG>CAG	p.R1290Q	NCOA2_uc011lfb.1_Missense_Mutation_p.R378Q	NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	1290					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			CTGGGGAATCCGAGGGTTGCT	0.502			NA	T	RUNXBP2	AML								13	19					0	0	0.001855	0	0
TRPA1	8989	broad.mit.edu	37	8	72936059	72936059	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:72936059G>T	uc003xza.2	-	26	3314	c.3139C>A	c.(3139-3141)CAG>AAG	p.Q1047K	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	1047	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	CGGTATTTCTGCTTTAATATT	0.259			NA											17	53					1.02788e-11	1.44747e-11	0.00499	1	0
KCNB2	9312	broad.mit.edu	37	8	73849198	73849198	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:73849198T>A	uc003xzb.2	+	3	2196	c.1608T>A	c.(1606-1608)AGT>AGA	p.S536R		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	536	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			AGCATCTGAGTGCCCAGAAAC	0.498			NA											25	38					0	0	0.003954	0	0
KCNB2	9312	broad.mit.edu	37	8	73849614	73849614	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:73849614C>A	uc003xzb.2	+	3	2612	c.2024C>A	c.(2023-2025)ACT>AAT	p.T675N		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	675	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			GTTGACATAACTGTGAACCTC	0.547			NA											17	41					2.35188e-11	3.27673e-11	0.006122	1	0
ZFHX4	79776	broad.mit.edu	37	8	77617213	77617213	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:77617213C>A	uc003yav.2	+	2	1277	c.890C>A	c.(889-891)GCT>GAT	p.A297D	ZFHX4_uc003yat.1_Missense_Mutation_p.A297D|ZFHX4_uc003yau.1_Missense_Mutation_p.A297D|ZFHX4_uc003yaw.1_Missense_Mutation_p.A297D	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	297						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GTAACCCATGCTGTGCATGAT	0.423			NA								HNSCC(33;0.089)			20	53					1.55795e-14	2.3748e-14	0.001882	1	0
ZFHX4	79776	broad.mit.edu	37	8	77768454	77768454	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:77768454C>A	uc003yav.2	+	10	9549	c.9162C>A	c.(9160-9162)CCC>CCA	p.P3054P	ZFHX4_uc003yau.1_Silent_p.P3099P|ZFHX4_uc003yaw.1_Silent_p.P3054P	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3054	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAGCCTACCCCGGACTCCCCG	0.542			NA								HNSCC(33;0.089)			20	41					3.51602e-12	5.03485e-12	0.008871	1	0
ZFHX4	79776	broad.mit.edu	37	8	77775757	77775757	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:77775757G>T	uc003yav.2	+	11	10059	c.9672G>T	c.(9670-9672)GGG>GGT	p.G3224G		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3220						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTATCCCTGGGTTTGCTTCTT	0.493			NA								HNSCC(33;0.089)			20	80					1.55795e-14	2.3748e-14	0.001882	1	0
ZFHX4	79776	broad.mit.edu	37	8	77776468	77776468	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:77776468G>A	uc003yav.2	+	11	10770	c.10383G>A	c.(10381-10383)CAG>CAA	p.Q3461Q		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3457	Ser-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTACCTCGCAGTCTGCAGCTT	0.438			NA								HNSCC(33;0.089)			23	15					0	0	0.003954	0	0
LRRCC1	85444	broad.mit.edu	37	8	86048158	86048158	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:86048158G>T	uc003ycw.2	+	14	2443	c.2289G>T	c.(2287-2289)AGG>AGT	p.R763S	LRRCC1_uc010maa.1_Missense_Mutation_p.R464S|LRRCC1_uc003ycx.2_Missense_Mutation_p.R670S|LRRCC1_uc003ycy.2_Missense_Mutation_p.R743S	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	763					cell division|mitosis	centriole|nucleus					0						TTGGTTTAAGGACAGAAAGAA	0.368			NA											13	40					1.35283e-19	2.28428e-19	0.004007	1	0
SLC26A7	115111	broad.mit.edu	37	8	92307860	92307860	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:92307860G>C	uc003yex.2	+	5	684	c.406G>C	c.(406-408)GGC>CGC	p.G136R	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Missense_Mutation_p.G136R|SLC26A7_uc003yfa.2_Missense_Mutation_p.G136R	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	136	Extracellular (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			AAGCGTGCTGGGCTTATCCGA	0.483			NA											28	41					0	0	0.004656	0	0
LRP12	29967	broad.mit.edu	37	8	105503727	105503727	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:105503727T>A	uc003yma.2	-	7	1849	c.1754A>T	c.(1753-1755)CAG>CTG	p.Q585L	LRP12_uc003ymb.2_Missense_Mutation_p.Q566L|LRP12_uc003ylz.2_5'UTR	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	585	Cytoplasmic (Potential).				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AAATCCAAGCTGAGATCGTAC	0.368			NA											21	28					0	0	0.00278	0	0
ZFPM2	23414	broad.mit.edu	37	8	106815547	106815547	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:106815547C>T	uc003ymd.2	+	8	3260	c.3237C>T	c.(3235-3237)ATC>ATT	p.I1079I	ZFPM2_uc011lhs.1_Silent_p.I810I	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	1079					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CCTCGTGGATCTCTGAGAACC	0.493			NA											7	17					0	0	0.001984	0	0
ZFPM2	23414	broad.mit.edu	37	8	106815570	106815570	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:106815570A>G	uc003ymd.2	+	8	3283	c.3260A>G	c.(3259-3261)AAT>AGT	p.N1087S	ZFPM2_uc011lhs.1_Missense_Mutation_p.N818S	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	1087					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TTAGCTGCCAATGAGAATGTC	0.498			NA											8	21					0	0	0.004482	0	0
ENY2	56943	broad.mit.edu	37	8	110355686	110355686	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:110355686C>A	uc003ynd.2	+	5	344	c.282C>A	c.(280-282)TTC>TTA	p.F94L	ENY2_uc003ync.2_Missense_Mutation_p.F89L	NM_020189	NP_064574	Q9NPA8	ENY2_HUMAN	enhancer of yellow 2 homolog	94					histone deubiquitination|mRNA transport|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity				0	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;9.05e-13)			TAAGAACATTCCTTGCTCAGC	0.328			NA											39	57					1.02591e-13	1.53301e-13	0.002522	1	0
CSMD3	114788	broad.mit.edu	37	8	113484862	113484863	+	Nonsense_Mutation	DNP	CC	CC	AT			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:113484862_113484863CC>AT	uc003ynu.2	-	32	5511_5512	c.5352_5353GG>AT	c.(5350-5355)GTGGGA>GTATGA	p.G1785*	CSMD3_uc003yns.2_Nonsense_Mutation_p.G1057*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.G1745*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.G1681*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1785	Extracellular (Potential).|CUB 10.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CAATTATGTCCCACACTGTAAT	0.361			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	69					0	0	0.004672	0	0
CSMD3	114788	broad.mit.edu	37	8	113697930	113697930	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:113697930C>T	uc003ynu.2	-	15	2346	c.2187G>A	c.(2185-2187)ATG>ATA	p.M729I	CSMD3_uc003yns.2_Missense_Mutation_p.M1I|CSMD3_uc003ynt.2_Missense_Mutation_p.M689I|CSMD3_uc011lhx.1_Missense_Mutation_p.M625I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	729	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GAACTGTTCCCATTGGTGCAG	0.353			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			26	40					0	0	0.005443	0	0
FER1L6	654463	broad.mit.edu	37	8	125074109	125074109	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:125074109A>G	uc003yqw.2	+	25	3370	c.3164A>G	c.(3163-3165)GAG>GGG	p.E1055G	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1055	Cytoplasmic (Potential).|C2 4.					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CCTGAGAACGAGCTTCTGCAC	0.567			NA											11	42					0	0	0.000978	0	0
TG	7038	broad.mit.edu	37	8	133912572	133912572	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:133912572A>T	uc003ytw.2	+	15	3462	c.3421A>T	c.(3421-3423)AGC>TGC	p.S1141C	TG_uc010mdw.2_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1141	Thyroglobulin type-1 9.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TGGCTCGAGCAGCAGTGCCCA	0.478			NA											9	7					0	0	0.004482	0	0
FAM135B	51059	broad.mit.edu	37	8	139163958	139163958	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:139163958G>T	uc003yuy.2	-	13	2931	c.2760C>A	c.(2758-2760)AAC>AAA	p.N920K	FAM135B_uc003yux.2_Missense_Mutation_p.N821K|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.N482K|FAM135B_uc003yvb.2_Missense_Mutation_p.N482K	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	920										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AGATGCCACTGTTGGAAAGAG	0.507			NA								HNSCC(54;0.14)			28	82					7.76418e-22	1.3538e-21	0.005443	1	0
FAM135B	51059	broad.mit.edu	37	8	139278033	139278033	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:139278033C>A	uc003yuy.2	-	4	381	c.210G>T	c.(208-210)CGG>CGT	p.R70R	FAM135B_uc003yux.2_5'UTR|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	70										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TCTGAAAGACCCGGCTGTGCA	0.478			NA								HNSCC(54;0.14)			16	33					1.99824e-07	2.46911e-07	0.00499	1	0
COL22A1	169044	broad.mit.edu	37	8	139791781	139791781	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:139791781G>T	uc003yvd.2	-	14	2122	c.1675C>A	c.(1675-1677)CCG>ACG	p.P559T		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	559	Pro-rich.|Gly-rich.|Collagen-like 2.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GGCAGCCCCGGCTCTCCCAGC	0.607			NA								HNSCC(7;0.00092)			27	27					8.16721e-17	1.30712e-16	0.002096	1	0
KCNK9	51305	broad.mit.edu	37	8	140631244	140631244	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:140631244G>T	uc003yvf.1	-	2	446	c.382C>A	c.(382-384)CTG>ATG	p.L128M	KCNK9_uc003yvg.1_Missense_Mutation_p.L128M|KCNK9_uc003yve.1_RNA	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	128	Helical; (Potential).					integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			CGCTCGCCCAGGCTCTGGAAC	0.587			NA											11	19					2.80697e-09	3.68639e-09	0.000978	1	0
PLEC	5339	broad.mit.edu	37	8	144991533	144991533	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr8:144991533C>T	uc003zaf.1	-	32	13037	c.12867G>A	c.(12865-12867)ATG>ATA	p.M4289I	PLEC_uc003zab.1_Missense_Mutation_p.M4152I|PLEC_uc003zac.1_Missense_Mutation_p.M4156I|PLEC_uc003zad.2_Missense_Mutation_p.M4152I|PLEC_uc003zae.1_Missense_Mutation_p.M4120I|PLEC_uc003zag.1_Missense_Mutation_p.M4130I|PLEC_uc003zah.2_Missense_Mutation_p.M4138I|PLEC_uc003zaj.2_Missense_Mutation_p.M4179I	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4289	Binding to intermediate filaments (By similarity).|Globular 2.|Plectin 27.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGTACACTGACATCTCCTTGC	0.622			NA											23	28					0	0	0.003954	0	0
DOCK8	81704	broad.mit.edu	37	9	376232	376232	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:376232C>T	uc003zgf.2	+	19	2244	c.2132C>T	c.(2131-2133)CCC>CTC	p.P711L	DOCK8_uc010mgu.2_Missense_Mutation_p.P13L|DOCK8_uc010mgv.2_Missense_Mutation_p.P643L|DOCK8_uc010mgw.1_Missense_Mutation_p.P13L|DOCK8_uc003zgk.2_Missense_Mutation_p.P169L|DOCK8_uc003zgh.2_RNA	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	711					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		CAGAATCCTCCCATTAAGTGG	0.373			NA											33	103					0	0	0.002836	0	0
DOCK8	81704	broad.mit.edu	37	9	421071	421071	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:421071G>T	uc003zgf.2	+	32	4258	c.4146G>T	c.(4144-4146)CGG>CGT	p.R1382R	DOCK8_uc010mgu.2_Silent_p.R684R|DOCK8_uc010mgv.2_Silent_p.R1282R|DOCK8_uc003zgk.2_Silent_p.R840R	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1382	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		TGCGCCGCCGGGCTCCAGGTG	0.572			NA											64	17					3.58576e-35	6.75904e-35	0.00361	1	0
SMARCA2	6595	broad.mit.edu	37	9	2110400	2110400	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:2110400G>A	uc003zhc.2	+	24	3538	c.3439G>A	c.(3439-3441)GAC>AAC	p.D1147N	SMARCA2_uc003zhd.2_Missense_Mutation_p.D1147N|SMARCA2_uc010mha.2_Missense_Mutation_p.D1080N	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1147	Helicase C-terminal.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CTTTGACAGCGACTGGAATCC	0.483			NA											12	10					0	0	0.001855	0	0
SMARCA2	6595	broad.mit.edu	37	9	2115969	2115969	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:2115969G>T	uc003zhc.2	+	25	3703	c.3604G>T	c.(3604-3606)GGC>TGC	p.G1202C	SMARCA2_uc003zhd.2_Missense_Mutation_p.G1202C|SMARCA2_uc010mha.2_Missense_Mutation_p.G1135C	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1202	Helicase C-terminal.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		GATCCAGGCGGGCATGTTTGA	0.532			NA									OREG0019074	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	8					1.67942e-08	2.14882e-08	0.006122	1	0
KCNV2	169522	broad.mit.edu	37	9	2718331	2718331	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:2718331T>A	uc003zho.1	+	1	806	c.592T>A	c.(592-594)TGC>AGC	p.C198S		NM_133497	NP_598004	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	198	Extracellular (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(50;0.0257)		CACGCCACGCTGCTGCCGCAT	0.697			NA											3	9					0	0	0.004672	0	0
KCNV2	169522	broad.mit.edu	37	9	2729457	2729457	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:2729457C>A	uc003zho.1	+	2	1582	c.1368C>A	c.(1366-1368)TCC>TCA	p.S456S		NM_133497	NP_598004	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	456						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(50;0.0257)		TGAGCATCTCCACCGTGGGCT	0.532			NA											35	13					1.15183e-24	2.08399e-24	0.009718	1	0
PTPRD	5789	broad.mit.edu	37	9	8499771	8499771	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:8499771C>T	uc003zkk.2	-	24	2909	c.2198G>A	c.(2197-2199)CGC>CAC	p.R733H	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Missense_Mutation_p.R733H|PTPRD_uc003zkm.2_Missense_Mutation_p.R720H|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	733	Fibronectin type-III 5.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CACGGGTGAGCGCCATGAGAC	0.473			NA								TSP Lung(15;0.13)			47	23					0	0	0.00361	0	0
FREM1	158326	broad.mit.edu	37	9	14737481	14737481	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:14737481A>T	uc003zlm.2	-	37	7043	c.6453T>A	c.(6451-6453)TGT>TGA	p.C2151*	FREM1_uc010mic.2_RNA|FREM1_uc003zlk.2_RNA|FREM1_uc003zll.2_Nonsense_Mutation_p.C687*	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	2151	C-type lectin.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		GAACCAAAACACAGCTCTTTC	0.473			NA											28	9					0	0	0.005443	0	0
FREM1	158326	broad.mit.edu	37	9	14824823	14824823	+	Silent	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:14824823A>T	uc003zlm.2	-	11	2639	c.2049T>A	c.(2047-2049)ACT>ACA	p.T683T	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	683	CSPG 4.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		ATGGAGGAGTAGTTATTGTGT	0.383			NA											8	6					0	0	0.00308	0	0
FREM1	158326	broad.mit.edu	37	9	14857621	14857621	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:14857621G>A	uc003zlm.2	-	5	1348	c.758C>T	c.(757-759)CCT>CTT	p.P253L	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	253					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		GTTGGGTGAAGGGGGATCCAG	0.493			NA											26	110					0	0	0.005443	0	0
SLC24A2	25769	broad.mit.edu	37	9	19619672	19619672	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:19619672G>C	uc003zoa.1	-	3	1050	c.988C>G	c.(988-990)CGA>GGA	p.R330G	SLC24A2_uc003zob.1_Missense_Mutation_p.R330G	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	330	Cytoplasmic (Potential).				visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		CTTCCACCTCGCTGGAGACGC	0.493			NA											20	81					0	0	0.008871	0	0
OR13J1	392309	broad.mit.edu	37	9	35869685	35869685	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:35869685G>A	uc011lph.1	-	1	714	c.714C>T	c.(712-714)TTC>TTT	p.F238F		NM_001004487	NP_001004487	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J,	238	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			AGCAGGTGGAGAAGGCTTTGC	0.567			NA											9	13					0	0	0.004482	0	0
OR13J1	392309	broad.mit.edu	37	9	35869736	35869736	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:35869736G>A	uc011lph.1	-	1	663	c.663C>T	c.(661-663)ATC>ATT	p.I221I		NM_001004487	NP_001004487	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			TGGTGGCCAGGATGAGCAAGT	0.617			NA											15	11					0	0	0.003163	0	0
OR13J1	392309	broad.mit.edu	37	9	35869787	35869787	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:35869787G>T	uc011lph.1	-	1	612	c.612C>A	c.(610-612)ATC>ATA	p.I204I		NM_001004487	NP_001004487	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			GCAGCAGCAGGATGGAGCCCG	0.617			NA											15	13					1.49906e-05	1.72931e-05	0.00245	1	0
OR13J1	392309	broad.mit.edu	37	9	35869804	35869804	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:35869804G>C	uc011lph.1	-	1	595	c.595C>G	c.(595-597)CTG>GTG	p.L199V		NM_001004487	NP_001004487	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			CCCGCCAGCAGGAAGTCTTCG	0.627			NA											13	17					0	0	0.001855	0	0
CDC14B	8555	broad.mit.edu	37	9	99314142	99314142	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:99314142C>A	uc004awj.2	-	5	885	c.433G>T	c.(433-435)GGG>TGG	p.G145W	CDC14B_uc004awk.2_Missense_Mutation_p.G145W|CDC14B_uc004awl.2_RNA|CDC14B_uc004awi.2_Missense_Mutation_p.G108W	NM_033331	NP_201588	O60729	CC14B_HUMAN	CDC14 homolog B isoform 2	145	A.				activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GGGGTTCTCCCCAAATATATA	0.328			NA											30	22					1.16021e-09	1.53207e-09	0.007291	1	0
ANKS6	203286	broad.mit.edu	37	9	101536239	101536239	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:101536239C>A	uc004ayu.2	-	9	1762	c.1741G>T	c.(1741-1743)GGG>TGG	p.G581W	ANKS6_uc004ayt.2_Missense_Mutation_p.G280W|ANKS6_uc004ayv.1_Missense_Mutation_p.G43W|ANKS6_uc004ayw.1_Missense_Mutation_p.G163W|ANKS6_uc004ayx.1_RNA|ANKS6_uc004ayy.1_RNA	NM_173551	NP_775822	Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain	581										ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)				TCTGCCTTCCCGTTGTGACGC	0.617			NA											21	21					3.28513e-13	4.81418e-13	0.003954	1	0
NR4A3	8013	broad.mit.edu	37	9	102595026	102595026	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:102595026T>G	uc004baf.1	+	4	1736	c.1007T>G	c.(1006-1008)GTA>GGA	p.V336G	NR4A3_uc004bae.2_Missense_Mutation_p.V336G|NR4A3_uc004bag.1_Missense_Mutation_p.V336G|NR4A3_uc004bai.2_Missense_Mutation_p.V347G	NM_006981	NP_008912	Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	336	Nuclear receptor.|NR C4-type.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		EWSR1/NR4A3(140)|TAF15/NR4A3(33)	bone(173)	173		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				AACTGCCCAGTAGACAAGAGA	0.373			NA	T	EWSR1	extraskeletal myxoid chondrosarcoma								49	22					0	0	0.00361	0	0
MURC	347273	broad.mit.edu	37	9	103348308	103348308	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:103348308A>G	uc004bba.2	+	2	760	c.670A>G	c.(670-672)AGA>GGA	p.R224G		NM_001018116	NP_001018126	Q5BKX8	MURC_HUMAN	muscle-related coiled-coil protein	224	Potential.				cell differentiation|muscle organ development|transcription, DNA-dependent					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0461)				AATTAGAACTAGAATAGTGAC	0.468			NA											62	29					0	0	0.00361	0	0
SVEP1	79987	broad.mit.edu	37	9	113198698	113198698	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:113198698G>A	uc010mtz.2	-	28	5063	c.4726C>T	c.(4726-4728)CAG>TAG	p.Q1576*		NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1576	Pentaxin.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						AGGTTGAGCTGGCTTATGGAG	0.468			NA											21	18					0	0	0.010504	0	0
RNF183	138065	broad.mit.edu	37	9	116060189	116060189	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:116060189G>A	uc004bgz.2	-	2	394	c.276C>T	c.(274-276)ATC>ATT	p.I92I	RNF183_uc004bha.2_Silent_p.I92I	NM_145051	NP_659488	Q96D59	RN183_HUMAN	ring finger protein 183	92						integral to membrane	zinc ion binding				0						GGCCTTCCAGGATGACATGGT	0.662			NA											26	13					0	0	0.005443	0	0
ASTN2	23245	broad.mit.edu	37	9	119903754	119903754	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:119903754G>A	uc004bjs.1	-	4	1120	c.1019C>T	c.(1018-1020)GCA>GTA	p.A340V	ASTN2_uc004bjr.1_Missense_Mutation_p.A340V|ASTN2_uc004bjt.1_Intron	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	340	Cytoplasmic (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CGCCTCAGCTGCTGCTATAAG	0.587			NA											16	9					0	0	0.004007	0	0
RABGAP1	23637	broad.mit.edu	37	9	125751575	125751575	+	Splice_Site	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:125751575G>A	uc011lzh.1	+	5	725	c.591_splice	c.e5-1	p.R197_splice	RABGAP1_uc004bnl.3_Splice_Site|RABGAP1_uc004bnm.1_Splice_Site_p.R197_splice	NM_012197	NP_036329	Q9Y3P9	RBGP1_HUMAN	RAB GTPase activating protein 1						cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			ovary(3)|kidney(2)	5						TCTCTGAACAGACTCTTAGAT	0.383			NA											9	36					0	0	0.008291	0	0
LHX2	9355	broad.mit.edu	37	9	126794863	126794863	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:126794863C>A	uc004boe.1	+	5	1837	c.1098C>A	c.(1096-1098)ACC>ACA	p.T366T	LHX2_uc010mwi.1_Silent_p.T374T	NM_004789	NP_004780	P50458	LHX2_HUMAN	LIM homeobox protein 2	366						nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CGCCCACCACCCTGACAGACT	0.647			NA											13	13					2.27111e-07	2.78718e-07	0.001368	1	0
NTNG2	84628	broad.mit.edu	37	9	135102355	135102355	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:135102355G>T	uc004cbh.2	+	4	1753	c.977G>T	c.(976-978)CGG>CTG	p.R326L		NM_032536	NP_115925	Q96CW9	NTNG2_HUMAN	netrin G2 precursor	326	Laminin EGF-like 1.				axonogenesis	anchored to plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		TTCCGCACCCGGTCCTGGCGG	0.667			NA											6	7					0.00116845	0.00125927	0.001168	1	0
ADAMTS13	11093	broad.mit.edu	37	9	136324098	136324098	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:136324098C>T	uc004cdv.3	+	29	4524	c.4080C>T	c.(4078-4080)ATC>ATT	p.I1360I	ADAMTS13_uc004cdp.3_Missense_Mutation_p.P470S|ADAMTS13_uc004cdt.1_Silent_p.I1304I|ADAMTS13_uc004cdu.1_Silent_p.I1273I|ADAMTS13_uc004cdw.3_Silent_p.I1304I|ADAMTS13_uc004cdx.3_Silent_p.I1273I|ADAMTS13_uc004cdz.3_Silent_p.I1030I|ADAMTS13_uc004ceb.3_Silent_p.I156I|C9orf7_uc011mdg.1_5'Flank|C9orf7_uc004cec.2_5'Flank|C9orf7_uc011mdh.1_5'Flank|C9orf7_uc011mdi.1_5'Flank|C9orf7_uc010nan.2_5'Flank	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1360	CUB 2.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		TCTCTCAGATCCGGGACACCC	0.428			NA											14	10					0	0	0.003163	0	0
VAV2	7410	broad.mit.edu	37	9	136656922	136656922	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:136656922T>A	uc004ces.2	-	13	1217	c.1171A>T	c.(1171-1173)AGT>TGT	p.S391C	VAV2_uc004cer.2_Missense_Mutation_p.S386C|VAV2_uc004cet.1_5'Flank	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	391					angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		TCTATAGAACTCTGAAATTCG	0.463			NA											39	24					0	0	0.009718	0	0
COL5A1	1289	broad.mit.edu	37	9	137623971	137623971	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:137623971C>T	uc004cfe.2	+	9	1769	c.1387C>T	c.(1387-1389)CCG>TCG	p.P463S		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	463	Interrupted collagenous region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GATTATCGAGCCGGTGAGGAC	0.582			NA											30	20					0	0	0.008361	0	0
C9orf163	158055	broad.mit.edu	37	9	139379174	139379174	+	Missense_Mutation	SNP	G	G	T	rs142971274		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:139379174G>T	uc004chy.2	+	1	1228	c.274G>T	c.(274-276)GTG>TTG	p.V92L	SEC16A_uc004chx.2_5'Flank|SEC16A_uc010nbo.1_5'Flank	NM_152571	NP_689784	Q8N9P6	CI163_HUMAN	hypothetical protein LOC158055	92							protein binding				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.36e-06)|Epithelial(140;5.65e-06)		TCCGGCTGACGTGGCACCAGG	0.632			NA											19	13					3.5997e-14	5.43536e-14	0.002299	1	0
ABCA2	20	broad.mit.edu	37	9	139913231	139913231	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr9:139913231C>A	uc011mem.1	-	12	1904	c.1756G>T	c.(1756-1758)GAG>TAG	p.E586*	ABCA2_uc011mel.1_Nonsense_Mutation_p.E587*|ABCA2_uc004ckl.1_Nonsense_Mutation_p.E517*|ABCA2_uc004ckm.1_Nonsense_Mutation_p.E617*|ABCA2_uc004ckn.1_5'Flank|ABCA2_uc004cko.1_Nonsense_Mutation_p.E363*	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	586					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		ACAATGCTCTCCTCGTCGTGG	0.512			NA											5	25					3.59834e-05	4.10182e-05	0.001168	1	0
ASMT	438	broad.mit.edu	37	X	1742071	1742071	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:1742071C>G	uc004cqd.2	+	3	254	c.109C>G	c.(109-111)CTC>GTC	p.L37V	ASMT_uc010ncy.2_Missense_Mutation_p.L37V|ASMT_uc004cqe.2_Missense_Mutation_p.L37V	NM_004043	NP_004034	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	37					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GTTTGACCTTCTCGCCGAGGC	0.637			NA											9	21					0	0	0.004482	0	0
ZBED1	9189	broad.mit.edu	37	X	2407570	2407570	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:2407570C>A	uc004cqg.2	-	2	1392	c.1191G>T	c.(1189-1191)CTG>CTT	p.L397L	DHRSX_uc004cqf.3_Intron|ZBED1_uc004cqh.1_Silent_p.L397L	NM_004729	NP_004720	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	397						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGAGCTCCACCAGCCCCTCGA	0.632			NA											19	13					2.4624e-09	3.23976e-09	0.008871	1	0
XG	7499	broad.mit.edu	37	X	2712644	2712644	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:2712644G>T	uc011mhg.1	+	6	545	c.322G>T	c.(322-324)GGA>TGA	p.G108*	XG_uc004cqp.2_Nonsense_Mutation_p.G108*	NM_175569	NP_780778	P55808	XG_HUMAN	XG glycoprotein isoform 1 precursor	108	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				GCCGCCTGCAGGTAGGTGCCG	0.612			NA											5	10					3.59834e-05	4.10182e-05	0.001168	1	0
GYG2	8908	broad.mit.edu	37	X	2773087	2773087	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:2773087G>A	uc004cqs.1	+	6	753	c.471G>A	c.(469-471)CCG>CCA	p.P157P	GYG2_uc004cqt.1_Silent_p.P126P|GYG2_uc004cqu.1_Silent_p.P126P|GYG2_uc004cqv.1_5'UTR|GYG2_uc004cqw.1_Silent_p.P117P|GYG2_uc004cqx.1_Silent_p.P126P|GYG2_uc010ndc.1_5'UTR	NM_003918	NP_003909	O15488	GLYG2_HUMAN	glycogenin 2 isoform b	157					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|soluble fraction	glycogenin glucosyltransferase activity			ovary(1)|kidney(1)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CTGCGGCCCCGGACCCCGGAT	0.557			NA											25	57					0	0	0.003954	0	0
HCCS	3052	broad.mit.edu	37	X	11132993	11132993	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:11132993G>T	uc004cuk.2	+	3	405	c.139G>T	c.(139-141)GAG>TAG	p.E47*	HCCS_uc004cuj.2_Nonsense_Mutation_p.E47*|HCCS_uc004cul.1_Nonsense_Mutation_p.E47*	NM_005333	NP_005324	P53701	CCHL_HUMAN	holocytochrome c synthase	47					organ morphogenesis|oxidation-reduction process	mitochondrial inner membrane	holocytochrome-c synthase activity|metal ion binding				0						CCCAACCTGTGAGAAGAAAAC	0.483	Ovarian(86;1338 1347 1462 10340 37882)		NA											26	43					6.32553e-13	9.19498e-13	0.004656	1	0
ARHGAP6	395	broad.mit.edu	37	X	11207050	11207050	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:11207050C>A	uc004cup.1	-	4	1748	c.875G>T	c.(874-876)AGG>ATG	p.R292M	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.R292M|ARHGAP6_uc004cum.1_Missense_Mutation_p.R89M|ARHGAP6_uc004cun.1_Missense_Mutation_p.R112M|ARHGAP6_uc010neb.1_Missense_Mutation_p.R114M|ARHGAP6_uc011mif.1_Missense_Mutation_p.R89M	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	292					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						TTTATAGGCCCTGTCATTCGC	0.443			NA											18	39					6.49762e-13	9.4072e-13	0.006122	1	0
ASB11	140456	broad.mit.edu	37	X	15301747	15301747	+	Silent	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:15301747T>A	uc004cwp.1	-	7	852	c.852A>T	c.(850-852)CCA>CCT	p.P284P	ASB11_uc004cwo.1_Silent_p.P263P|ASB11_uc010nes.1_RNA|ASB11_uc010net.1_Silent_p.P267P	NM_080873	NP_543149	Q8WXH4	ASB11_HUMAN	ankyrin repeat and SOCS box-containing protein	284	SOCS box.				intracellular signal transduction					breast(2)|skin(1)	3	Hepatocellular(33;0.183)					AAAGAGCAGGTGGGCCTGAGA	0.517			NA											20	58					0	0	0.010504	0	0
ACE2	59272	broad.mit.edu	37	X	15607532	15607532	+	Missense_Mutation	SNP	C	C	A	rs148771870	byFrequency	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:15607532C>A	uc004cxa.1	-	5	799	c.631G>T	c.(631-633)GGG>TGG	p.G211W	ACE2_uc004cxb.2_Missense_Mutation_p.G211W	NM_021804	NP_068576	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2 precursor	211	Extracellular (Potential).				angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			ovary(3)	3	Hepatocellular(33;0.183)				Moexipril(DB00691)	CCATCTACCCCATTTACTTCA	0.408			NA											59	141					1.77791e-30	3.3038e-30	0.00361	1	0
RAI2	10742	broad.mit.edu	37	X	17818977	17818977	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:17818977G>C	uc004cyf.2	-	3	1724	c.1154C>G	c.(1153-1155)TCT>TGT	p.S385C	RAI2_uc004cyg.2_Missense_Mutation_p.S385C|RAI2_uc010nfa.2_Missense_Mutation_p.S385C|RAI2_uc004cyh.3_Missense_Mutation_p.S385C|RAI2_uc011miy.1_Missense_Mutation_p.S335C	NM_021785	NP_068557	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	385					embryo development					ovary(1)|breast(1)	2	Hepatocellular(33;0.183)					AGGGGCAAAAGAAATTTCCAT	0.557			NA											8	49					0	0	0.004482	0	0
BEND2	139105	broad.mit.edu	37	X	18221737	18221737	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:18221737C>A	uc004cyj.3	-	5	945	c.791G>T	c.(790-792)CGA>CTA	p.R264L	BEND2_uc010nfb.2_Missense_Mutation_p.R264L	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	264								p.R264*(1)		ovary(3)|kidney(1)|central_nervous_system(1)	5						GGATTCTCTTCGTGACAGAAC	0.463			NA											22	61					0.000229342	0.000254002	0.001882	1	0
CDKL5	6792	broad.mit.edu	37	X	18646665	18646665	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:18646665C>A	uc004cym.2	+	18	2924	c.2671C>A	c.(2671-2673)CAG>AAG	p.Q891K	CDKL5_uc004cyn.2_Missense_Mutation_p.Q891K	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	891					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					CAACATCCGGCAGGAACCCGC	0.602			NA											30	65					7.01153e-11	9.60174e-11	0.007291	1	0
MAP3K15	389840	broad.mit.edu	37	X	19392632	19392632	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:19392632G>C	uc004czk.1	-	21	2798	c.1161C>G	c.(1159-1161)AAC>AAG	p.N387K	MAP3K15_uc004czj.1_Missense_Mutation_p.N347K|MAP3K15_uc004czi.1_5'Flank	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	912							ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)					TCTTGCCCTTGTTCACCTGCC	0.577			NA											15	47					0	0	0.003163	0	0
MAP3K15	389840	broad.mit.edu	37	X	19392723	19392723	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:19392723C>T	uc004czk.1	-	21	2707	c.1070G>A	c.(1069-1071)CGA>CAA	p.R357Q	MAP3K15_uc004czj.1_Missense_Mutation_p.R317Q|MAP3K15_uc004czi.1_5'Flank	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	882	Protein kinase.						ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)					AATGAAGGCTCGGGCTTCAGC	0.527			NA											20	33					0	0	0.008871	0	0
CNKSR2	22866	broad.mit.edu	37	X	21627666	21627666	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:21627666G>T	uc004czx.1	+	20	2659	c.2623G>T	c.(2623-2625)GAG>TAG	p.E875*	CNKSR2_uc004czw.2_Nonsense_Mutation_p.E875*|CNKSR2_uc011mjn.1_Nonsense_Mutation_p.E826*|CNKSR2_uc011mjo.1_Nonsense_Mutation_p.E845*|CNKSR2_uc004czy.2_Nonsense_Mutation_p.E467*	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	875	Potential.|Poly-Glu.				regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						GCAACCCCCagaggtggagga	0.383			NA											15	27					1.3612e-06	1.62893e-06	0.003163	1	0
KLHL34	257240	broad.mit.edu	37	X	21675499	21675499	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:21675499G>C	uc004czz.1	-	1	950	c.408C>G	c.(406-408)AAC>AAG	p.N136K		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	136	BACK.									ovary(1)	1						GCGCTGCCACGTTGGCGGCGA	0.602			NA											2	2					0	0	0.004672	0	0
PHEX	5251	broad.mit.edu	37	X	22051130	22051130	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:22051130G>C	uc004dah.2	+	1	210	c.7G>C	c.(7-9)GCA>CCA	p.A3P	PHEX_uc011mjr.1_Missense_Mutation_p.A3P	NM_000444	NP_000435	P78562	PHEX_HUMAN	phosphate-regulating neutral endopeptidase	3	Cytoplasmic (Potential).				biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3						TCTGATGGAAGCAGAAACAGG	0.542			NA											20	60					0	0	0.008871	0	0
POLA1	5422	broad.mit.edu	37	X	24751887	24751887	+	Missense_Mutation	SNP	A	A	G	rs36086506		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:24751887A>G	uc004dbl.2	+	17	1792	c.1769A>G	c.(1768-1770)AAG>AGG	p.K590R	POLA1_uc004dbn.2_Missense_Mutation_p.K454R	NM_016937	NP_058633	P09884	DPOLA_HUMAN	DNA-directed DNA polymerase alpha 1	590					cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			ovary(2)|skin(1)	3					Clofarabine(DB00631)|Fludarabine(DB01073)	TCTAAACCAAAGGACTGTATT	0.328			NA											10	34					0	0	0.001368	0	0
DCAF8L2	347442	broad.mit.edu	37	X	27766228	27766229	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:27766228_27766229GG>TT	uc011mjy.1	+	1	1303_1304	c.1216_1217GG>TT	c.(1216-1218)GGC>TTC	p.G406F		NM_001136533	NP_001130005			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|pancreas(1)	2						AGAAAACAATGGCGTGCTCAAG	0.436			NA											13	24					0	0	0.004672	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27998524	27998524	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:27998524C>A	uc004dbx.1	-	1	1043	c.928G>T	c.(928-930)GTT>TTT	p.V310F		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	310	WD 3.									ovary(3)|skin(1)	4						GTGAACACAACGGCATCTTCA	0.483			NA											13	24					0.00244969	0.00261664	0.00245	1	0
MAGEB3	4114	broad.mit.edu	37	X	30254298	30254298	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:30254298C>A	uc004dca.1	+	5	994	c.257C>A	c.(256-258)GCC>GAC	p.A86D		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	86											0						TACAAGGGAGCCAACAGCAAA	0.448			NA											9	14					0.00448238	0.0047387	0.004482	1	0
MAGEB4	4115	broad.mit.edu	37	X	30260473	30260473	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:30260473C>T	uc004dcb.2	+	1	305	c.221C>T	c.(220-222)GCT>GTT	p.A74V	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	74										ovary(1)	1						GCTGCTGCAGCTATGTCATGC	0.522			NA											7	28					0	0	0.00308	0	0
TAB3	257397	broad.mit.edu	37	X	30849675	30849675	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:30849675T>A	uc004dcj.2	-	11	2671	c.2008A>T	c.(2008-2010)ACA>TCA	p.T670S	TAB3_uc004dck.2_Missense_Mutation_p.T670S|TAB3_uc010ngl.2_Missense_Mutation_p.T642S	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	670					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1						GGACTTTGTGTGGAGCCAGTT	0.458	Pancreas(164;1598 1985 29022 43301 49529)		NA											8	22					0	0	0.004482	0	0
DMD	1756	broad.mit.edu	37	X	31279119	31279119	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:31279119G>T	uc004dda.1	-	63	9483	c.9239C>A	c.(9238-9240)ACA>AAA	p.T3080K	DMD_uc004dcq.1_Missense_Mutation_p.T351K|DMD_uc004dcr.1_Missense_Mutation_p.T620K|DMD_uc004dcs.1_Missense_Mutation_p.T620K|DMD_uc004dct.1_Missense_Mutation_p.T620K|DMD_uc004dcu.1_Missense_Mutation_p.T620K|DMD_uc004dcv.1_Missense_Mutation_p.T620K|DMD_uc004dcw.2_Missense_Mutation_p.T1736K|DMD_uc004dcx.2_Missense_Mutation_p.T1739K|DMD_uc004dcz.2_Missense_Mutation_p.T2957K|DMD_uc004dcy.1_Missense_Mutation_p.T3076K|DMD_uc004ddb.1_Missense_Mutation_p.T3072K|DMD_uc004dcm.1_Missense_Mutation_p.T12K|DMD_uc004dcn.1_Missense_Mutation_p.T12K|DMD_uc004dco.1_Missense_Mutation_p.T12K|DMD_uc004dcp.1_Missense_Mutation_p.T12K|DMD_uc011mkb.1_Missense_Mutation_p.T12K|DMD_uc010ngm.2_Missense_Mutation_p.T12K	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3080	Interaction with SYNM (By similarity).|WW.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CCAGCAAGTTGTTTGAGTCTC	0.378			NA											7	21					0.000157383	0.000174574	0.00308	1	0
DMD	1756	broad.mit.edu	37	X	32366641	32366641	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:32366641G>A	uc004dda.1	-	38	5574	c.5330C>T	c.(5329-5331)TCC>TTC	p.S1777F	DMD_uc004dcw.2_Missense_Mutation_p.S433F|DMD_uc004dcx.2_Missense_Mutation_p.S436F|DMD_uc004dcz.2_Missense_Mutation_p.S1654F|DMD_uc004dcy.1_Missense_Mutation_p.S1773F|DMD_uc004ddb.1_Missense_Mutation_p.S1769F|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1777	Spectrin 12.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CAAAGGAATGGAGGCCTAAAA	0.338			NA											6	18					0	0	0.001168	0	0
DMD	1756	broad.mit.edu	37	X	32632420	32632420	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:32632420C>G	uc004dda.1	-	12	1726	c.1482G>C	c.(1480-1482)AAG>AAC	p.K494N	DMD_uc004dcz.2_Missense_Mutation_p.K371N|DMD_uc004dcy.1_Missense_Mutation_p.K490N|DMD_uc004ddb.1_Missense_Mutation_p.K486N|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Missense_Mutation_p.K486N|DMD_uc010ngp.1_Intron|DMD_uc010ngq.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	494	Spectrin 2.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ATACACCTACCTTATGTTGTT	0.398			NA											14	34					0	0	0.004007	0	0
DMD	1756	broad.mit.edu	37	X	32717312	32717312	+	Nonsense_Mutation	SNP	C	C	A	rs128626239		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:32717312C>A	uc004dda.1	-	8	992	c.748G>T	c.(748-750)GAA>TAA	p.E250*	DMD_uc004dcz.2_Nonsense_Mutation_p.E127*|DMD_uc004dcy.1_Nonsense_Mutation_p.E246*|DMD_uc004ddb.1_Nonsense_Mutation_p.E242*|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Nonsense_Mutation_p.E242*|DMD_uc010ngp.1_Intron|DMD_uc010ngq.1_Intron|DMD_uc010ngr.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	250					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ATTTCCACTTCCTGGATGGCT	0.393			NA											22	61					1.28384e-07	1.59183e-07	0.001882	1	0
FAM47B	170062	broad.mit.edu	37	X	34961615	34961615	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:34961615C>A	uc004ddi.1	+	1	685	c.667C>A	c.(667-669)CTC>ATC	p.L223I		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	223	Pro-rich.									ovary(3)|breast(1)	4						GGTGTCCAGTCTCCGCCCAGA	0.662			NA											32	68					3.90053e-15	6.03494e-15	0.002445	1	0
FAM47C	442444	broad.mit.edu	37	X	37027912	37027912	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:37027912G>T	uc004ddl.1	+	1	1443	c.1429G>T	c.(1429-1431)GAG>TAG	p.E477*		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	477										ovary(3)	3						TCTCTGCCCGGAGCCTCCAGA	0.617			NA											27	76					4.59853e-10	6.12854e-10	0.005443	1	0
ZNF41	7592	broad.mit.edu	37	X	47308861	47308861	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:47308861C>A	uc004dhs.3	-	4	501	c.434G>T	c.(433-435)GGG>GTG	p.G145V	ZNF41_uc004dhu.3_Missense_Mutation_p.G137V|ZNF41_uc004dht.3_Missense_Mutation_p.G17V|ZNF41_uc004dhv.3_Missense_Mutation_p.G113V|ZNF41_uc004dhw.3_Missense_Mutation_p.G105V|ZNF41_uc004dhy.3_Missense_Mutation_p.G103V|ZNF41_uc004dhx.3_Missense_Mutation_p.G103V|ZNF41_uc011mlm.1_Missense_Mutation_p.G17V|ZNF41_uc004dhz.2_Intron|ZNF41_uc004dia.2_Intron	NM_153380	NP_700359	P51814	ZNF41_HUMAN	zinc finger protein 41	145						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3		all_lung(315;0.000129)				CTGCATTTTCCCAATAGCCTC	0.388			NA											6	13					8.12818e-05	9.09297e-05	0.001984	1	0
ZNF81	347344	broad.mit.edu	37	X	47755298	47755298	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:47755298C>A	uc010nhy.1	+	5	604	c.236C>A	c.(235-237)CCA>CAA	p.P79Q		NM_007137	NP_009068	P51508	ZNF81_HUMAN	zinc finger protein 81	79	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(315;0.0973)				GGAGAGGGGCCATGGACATTG	0.493			NA											7	16					1.67772e-17	2.72748e-17	0.000978	1	0
TIMM17B	10245	broad.mit.edu	37	X	48754135	48754135	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:48754135C>T	uc004dlc.1	-	3	182	c.33G>A	c.(31-33)TGG>TGA	p.W11*	PQBP1_uc004dle.2_5'Flank|PQBP1_uc004dlf.2_5'Flank|PQBP1_uc004dlg.2_5'Flank|PQBP1_uc004dld.2_5'Flank|PQBP1_uc004dlh.2_5'Flank|PQBP1_uc004dli.2_5'Flank|PQBP1_uc004dlj.1_5'Flank|PQBP1_uc004dln.2_5'Flank|PQBP1_uc010nih.2_5'Flank|PQBP1_uc010nii.2_5'Flank|PQBP1_uc004dlk.2_5'Flank|PQBP1_uc004dll.2_5'Flank|PQBP1_uc004dlm.2_5'Flank|PQBP1_uc010nij.2_5'Flank|TIMM17B_uc004dla.1_Nonsense_Mutation_p.W11*|TIMM17B_uc004dlb.1_5'UTR	NM_005834	NP_005825	O60830	TI17B_HUMAN	translocase of inner mitochondrial membrane 17	11					protein targeting to mitochondrion	integral to membrane|microtubule cytoskeleton|mitochondrial inner membrane presequence translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						CCACAATTCGCCATGGGCTGC	0.557			NA											11	37					0	0	0.001368	0	0
PIM2	11040	broad.mit.edu	37	X	48772330	48772330	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:48772330G>C	uc004dls.2	-	4	864	c.562C>G	c.(562-564)CTG>GTG	p.L188V		NM_006875	NP_006866	Q9P1W9	PIM2_HUMAN	serine/threonine protein kinase pim-2	188	Protein kinase.				anti-apoptosis|cell proliferation|male meiosis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|response to virus		ATP binding|protein serine/threonine kinase activity			lung(3)|stomach(1)	4						TCATGAAGCAGGGCACCAGAA	0.488			NA											7	38					0	0	0.001984	0	0
CCDC120	90060	broad.mit.edu	37	X	48923039	48923039	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:48923039G>T	uc010nik.2	+	8	1244	c.737G>T	c.(736-738)TGG>TTG	p.W246L	CCDC120_uc011mmq.1_Missense_Mutation_p.W234L|CCDC120_uc004dmf.2_Missense_Mutation_p.W246L|CCDC120_uc010nil.2_Missense_Mutation_p.W246L|CCDC120_uc011mmr.1_Missense_Mutation_p.W246L|CCDC120_uc011mms.1_Missense_Mutation_p.W234L	NM_033626	NP_296375	Q96HB5	CC120_HUMAN	coiled-coil domain containing 120 isoform 3	246							protein binding			pancreas(1)	1						CCCAAGGCTTGGGACCAGCTG	0.617			NA											10	26					2.17888e-05	2.49757e-05	0.006214	1	0
MAGIX	79917	broad.mit.edu	37	X	49022561	49022561	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:49022561C>A	uc010nin.1	+	6	875	c.828C>A	c.(826-828)GCC>GCA	p.A276A	MAGIX_uc010nio.1_Silent_p.A200A|MAGIX_uc004dmt.2_Silent_p.A195A|MAGIX_uc004dmu.2_Silent_p.A217A|MAGIX_uc004dmw.2_Silent_p.A204A	NM_024859	NP_079135	Q9H6Y5	MAGIX_HUMAN	MAGI family member, X-linked isoform a	276											0						CAGAGGCGGCCGCCGATGGCC	0.692			NA											7	17					0.00307968	0.003275	0.00308	1	0
PRICKLE3	4007	broad.mit.edu	37	X	49033386	49033386	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:49033386G>T	uc004dmy.1	-	8	1147	c.1121C>A	c.(1120-1122)GCT>GAT	p.A374D	PRICKLE3_uc011mmv.1_Missense_Mutation_p.A306D|PRICKLE3_uc011mmw.1_Missense_Mutation_p.A293D|PRICKLE3_uc011mmx.1_Missense_Mutation_p.A336D	NM_006150	NP_006141	O43900	PRIC3_HUMAN	LIM domain only 6	374				Missing (in Ref. 5; AAB92357).			protein binding|zinc ion binding			breast(1)	1						CGGCCCTGGAGCTGTGGGCTC	0.677			NA											9	23					0.000274275	0.000300993	0.004482	1	0
CCNB3	85417	broad.mit.edu	37	X	50051956	50051956	+	Missense_Mutation	SNP	A	A	T	rs142543110		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:50051956A>T	uc004dox.3	+	6	1085	c.787A>T	c.(787-789)ATG>TTG	p.M263L	CCNB3_uc004doy.2_Missense_Mutation_p.M263L|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	263					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					TTCCTTCTTTATGGAGTCAAT	0.413			NA											27	75					0	0	0.003954	0	0
CCNB3	85417	broad.mit.edu	37	X	50051958	50051958	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:50051958G>T	uc004dox.3	+	6	1087	c.789G>T	c.(787-789)ATG>ATT	p.M263I	CCNB3_uc004doy.2_Missense_Mutation_p.M263I|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	263					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					CCTTCTTTATGGAGTCAATGA	0.413			NA											23	71					3.8784e-16	6.12558e-16	0.001882	1	0
Unknown	0	broad.mit.edu	37	X	51150613	51150614	+	Missense_Mutation	DNP	CG	CG	AA			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:51150613_51150614CG>AA	uc004dpj.2	+	1	847_848	c.745_746CG>AA	c.(745-747)CGC>AAC	p.R249N		NM_203407	NP_981952			hypothetical protein LOC340602												NA						TTTTCCACACCGCGCCACTCAT	0.678			NA											3	13					0	0	0.004672	0	0
IQSEC2	23096	broad.mit.edu	37	X	53284096	53284096	+	Silent	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:53284096C>T	uc004dsd.2	-	4	1218	c.1017G>A	c.(1015-1017)AGG>AGA	p.R339R	IQSEC2_uc004dsc.2_Silent_p.R134R	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	329					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						CCCCATACTTCCTCTCCAGCA	0.592			NA											8	11					0	0	0.004482	0	0
WNK3	65267	broad.mit.edu	37	X	54334508	54334508	+	Silent	SNP	A	A	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:54334508A>G	uc004dtd.1	-	5	1375	c.936T>C	c.(934-936)ACT>ACC	p.T312T	WNK3_uc004dtc.1_Silent_p.T312T	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	312	Protein kinase.				intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						TAAACTCAGGAGTTCCTACAA	0.388			NA											11	26					0	0	0.001368	0	0
WNK3	65267	broad.mit.edu	37	X	54337693	54337693	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:54337693C>A	uc004dtd.1	-	3	1008	c.569G>T	c.(568-570)AGA>ATA	p.R190I	WNK3_uc004dtc.1_Missense_Mutation_p.R190I	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	190	Protein kinase.				intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						TTCCTTGAATCTTTGCTGCTC	0.358			NA											10	32					2.27111e-07	2.78718e-07	0.001368	1	0
GNL3L	54552	broad.mit.edu	37	X	54574706	54574706	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:54574706G>T	uc004dth.1	+	9	814	c.675G>T	c.(673-675)CTG>CTT	p.L225L	GNL3L_uc004dti.2_RNA	NM_019067	NP_061940	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3	225					ribosome biogenesis	nucleolus	GTP binding			ovary(1)	1						AGTCACTGCTGAAAAGCAAAG	0.493			NA											15	27					0.000422831	0.000463668	0.004007	1	0
APEX2	27301	broad.mit.edu	37	X	55033666	55033666	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:55033666G>T	uc004dtz.2	+	6	1431	c.1355G>T	c.(1354-1356)CGG>CTG	p.R452L	APEX2_uc011mom.1_Missense_Mutation_p.R281L	NM_014481	NP_055296	Q9UBZ4	APEX2_HUMAN	apurinic/apyrimidinic endonuclease 2	452					cell cycle|DNA recombination|DNA repair	nucleus	DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|exonuclease activity|zinc ion binding			breast(1)	1						AAGGAGTTACGGACCTCATTC	0.587			NA						Other_BER_factors					9	26					0.00448238	0.0047387	0.004482	1	0
PAGE5	90737	broad.mit.edu	37	X	55248250	55248250	+	Silent	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:55248250T>C	uc004duj.2	+	3	434	c.192T>C	c.(190-192)GAT>GAC	p.D64D	PAGE5_uc004duk.2_Silent_p.D44D	NM_130467	NP_569734	Q96GU1	GGEE1_HUMAN	P antigen family, member 5 isoform 1	64											0						CACCAACTGATAATCAGGGTA	0.453			NA											8	14					0	0	0.001368	0	0
RRAGB	10325	broad.mit.edu	37	X	55744767	55744767	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:55744767G>A	uc004dup.2	+	1	658	c.7G>A	c.(7-9)GAA>AAA	p.E3K	RRAGB_uc004duq.2_Missense_Mutation_p.E3K	NM_016656	NP_057740	Q5VZM2	RRAGB_HUMAN	Ras-related GTP binding B long isoform	3					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|signal transduction	Golgi apparatus|lysosome|nucleus	GTP binding|protein binding				0						CGCAATGGAAGAATCTGACTC	0.463			NA									OREG0019812	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	14					0	0	0.000602	0	0
FAM123B	139285	broad.mit.edu	37	X	63411982	63411982	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:63411982C>A	uc004dvo.2	-	2	1458	c.1185G>T	c.(1183-1185)GAG>GAT	p.E395D		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	395	Glu-rich.				Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						ccttaacctcctcttcttcct	0.333			NA											18	32					4.75885e-15	7.33932e-15	0.00499	1	0
LAS1L	81887	broad.mit.edu	37	X	64738059	64738059	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:64738059C>A	uc004dwa.1	-	12	1807	c.1735G>T	c.(1735-1737)GTA>TTA	p.V579L	LAS1L_uc004dwc.1_Missense_Mutation_p.V562L|LAS1L_uc004dwd.1_Missense_Mutation_p.V520L|LAS1L_uc004dvy.1_Missense_Mutation_p.V92L|LAS1L_uc004dvz.1_Missense_Mutation_p.V92L	NM_031206	NP_112483	Q9Y4W2	LAS1L_HUMAN	LAS1-like	579						MLL1 complex|nucleolus	protein binding			ovary(3)|large_intestine(1)	4						tcctcctcTACCTGGTCTGGC	0.343			NA											26	49					3.73148e-12	5.32751e-12	0.007291	1	0
AR	367	broad.mit.edu	37	X	66941747	66941747	+	Nonsense_Mutation	SNP	G	G	A	rs137852565		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:66941747G>A	uc004dwu.1	+	6	3506	c.2391G>A	c.(2389-2391)TGG>TGA	p.W797*	AR_uc004dwv.1_Nonsense_Mutation_p.W265*	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	796	Ligand-binding.|Interaction with MYST2.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	AGTTTGGATGGCTCCAAATCA	0.527			NA							Androgen_Insensitivity_Syndrome				16	29					0	0	0.00499	0	0
STARD8	9754	broad.mit.edu	37	X	67940832	67940832	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:67940832T>A	uc004dxa.2	+	8	2248	c.1876T>A	c.(1876-1878)TCG>ACG	p.S626T	STARD8_uc004dxb.2_Missense_Mutation_p.S706T|STARD8_uc004dxc.3_Missense_Mutation_p.S626T	NM_014725	NP_055540	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain	626	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			breast(3)|ovary(2)|pancreas(1)	6						GAATGAGACCTCGCCTGACAA	0.562			NA											12	36					0	0	0.001368	0	0
AWAT1	158833	broad.mit.edu	37	X	69455968	69455968	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:69455968C>A	uc004dxy.2	+	3	275	c.234C>A	c.(232-234)ATC>ATA	p.I78I		NM_001013579	NP_001013597	Q58HT5	AWAT1_HUMAN	wax synthase 1	78					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity			ovary(3)	3						GGACCCACATCAGGGACTATT	0.502			NA											14	26					5.01169e-05	5.67258e-05	0.00499	1	0
TEX11	56159	broad.mit.edu	37	X	69849524	69849524	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:69849524A>T	uc004dyl.2	-	19	1752	c.1590T>A	c.(1588-1590)GAT>GAA	p.D530E	TEX11_uc004dyk.2_Missense_Mutation_p.D205E|TEX11_uc004dym.2_Missense_Mutation_p.D515E	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	530							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					CTGCAACTAGATCATTATCTT	0.328			NA											17	46					0	0	0.004007	0	0
SLC7A3	84889	broad.mit.edu	37	X	70146814	70146814	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:70146814T>G	uc004dyn.2	-	9	1522	c.1364A>C	c.(1363-1365)AAG>ACG	p.K455T	SLC7A3_uc004dyo.2_Missense_Mutation_p.K455T	NM_032803	NP_116192	Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid	455	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				ovary(1)|kidney(1)	2	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	TAGGGTCAACTTCTCTGATTC	0.478			NA											8	45					0	0	0.00308	0	0
IL2RG	3561	broad.mit.edu	37	X	70327653	70327653	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:70327653G>T	uc004dyw.1	-	8	1057	c.1043C>A	c.(1042-1044)GCC>GAC	p.A348D	CXorf65_uc011mpo.1_5'Flank|CXorf65_uc011mpp.1_5'Flank|IL2RG_uc004dyv.1_Missense_Mutation_p.A77D|IL2RG_uc004dyx.1_Missense_Mutation_p.A158D	NM_000206	NP_000197	P31785	IL2RG_HUMAN	interleukin 2 receptor, gamma precursor	348	Cytoplasmic (Potential).				immune response|interleukin-4-mediated signaling pathway|interspecies interaction between organisms	external side of plasma membrane|integral to plasma membrane	cytokine receptor activity|interleukin-2 binding			pancreas(1)	1	Renal(35;0.156)				Aldesleukin(DB00041)|Denileukin diftitox(DB00004)	GCATGGGGAGGCCCCAGGCCC	0.602			NA							Severe_Combined_Immunodeficiency_X-linked				12	16					7.03913e-09	9.16103e-09	0.001368	1	0
ZMYM3	9203	broad.mit.edu	37	X	70466306	70466306	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:70466306G>A	uc004dzh.1	-	15	2556	c.2469C>T	c.(2467-2469)CCC>CCT	p.P823P	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Silent_p.P823P|ZMYM3_uc004dzj.1_Silent_p.P811P	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	823					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					GTGTTGCTGGGGGTGGTGGGG	0.572			NA											4	5					0	0	0.009096	0	0
ACRC	93953	broad.mit.edu	37	X	70824130	70824130	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:70824130C>A	uc004eae.2	+	8	1504	c.1003C>A	c.(1003-1005)CCT>ACT	p.P335T	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	335						nucleus				ovary(3)	3	Renal(35;0.156)					TTTGGAAGTTCCTGTGCCAGC	0.473			NA											29	58					4.87955e-14	7.3295e-14	0.005443	1	0
NHSL2	340527	broad.mit.edu	37	X	71360053	71360053	+	Silent	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:71360053C>G	uc011mqa.1	+	6	2655	c.2655C>G	c.(2653-2655)GTC>GTG	p.V885V	NHSL2_uc004eak.1_Silent_p.V519V|NHSL2_uc010nli.2_Silent_p.V654V	NM_001013627	NP_001013649	Q5HYW2	NHSL2_HUMAN	NHS-like 2	885											0	Renal(35;0.156)					CAAGCTTGGTCCACAAGCCAC	0.552			NA											8	33					0	0	0.004482	0	0
FLJ44635	392490	broad.mit.edu	37	X	71379738	71379738	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:71379738C>G	uc004eal.1	+	2	407	c.59C>G	c.(58-60)TCT>TGT	p.S20C		NM_207422	NP_997305	Q56UQ5	TPT1L_HUMAN	hypothetical protein LOC392490	20										lung(1)	1	Renal(35;0.156)					GAGATGTTCTCTGACAGTTAC	0.512			NA											13	25					0	0	0.001855	0	0
NAP1L2	4674	broad.mit.edu	37	X	72433876	72433876	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:72433876T>A	uc004ebi.2	-	1	809	c.453A>T	c.(451-453)AGA>AGT	p.R151S	NAP1L2_uc011mqj.1_Missense_Mutation_p.R9S	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	151					nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)					TGATCTGACGTCTTTTTTCCA	0.378			NA											37	77					0	0	0.003755	0	0
SLC16A2	6567	broad.mit.edu	37	X	73744385	73744385	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:73744385A>C	uc004ebt.2	+	3	1155	c.989A>C	c.(988-990)AAG>ACG	p.K330T	SLC16A2_uc010nlr.1_Missense_Mutation_p.K5T	NM_006517	NP_006508	P36021	MOT8_HUMAN	solute carrier family 16, member 2	256	Extracellular (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|ovary(1)	3					Pyruvic acid(DB00119)	CTGGGGGATAAGATCAAGCTG	0.547			NA											4	21					0	0	0.009096	0	0
ATRX	546	broad.mit.edu	37	X	76938718	76938718	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:76938718G>T	uc004ecp.3	-	9	2262	c.2030C>A	c.(2029-2031)TCA>TAA	p.S677*	ATRX_uc004ecq.3_Nonsense_Mutation_p.S639*|ATRX_uc004eco.3_Nonsense_Mutation_p.S462*|ATRX_uc004ecr.2_Nonsense_Mutation_p.S609*|ATRX_uc010nlx.1_Nonsense_Mutation_p.S648*|ATRX_uc010nly.1_Nonsense_Mutation_p.S622*	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	677					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTCTTCATCTGAATTAGATGT	0.373			NA	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						50	125					1.30916e-28	2.42338e-28	0.00361	1	0
ITM2A	9452	broad.mit.edu	37	X	78622626	78622626	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:78622626G>A	uc004edh.2	-	1	422	c.87C>T	c.(85-87)GTC>GTT	p.V29V	ITM2A_uc011mqr.1_Silent_p.V29V	NM_004867	NP_004858	O43736	ITM2A_HUMAN	integral membrane protein 2A	29						integral to membrane	protein binding			lung(2)	2						TCTGAGTTCTGACCGTGCGGC	0.582			NA											3	9					0	0	0.004672	0	0
CHM	1121	broad.mit.edu	37	X	85128136	85128136	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:85128136C>A	uc004eet.2	-	14	1721	c.1691G>T	c.(1690-1692)TGT>TTT	p.C564F	CHM_uc011mqz.1_Missense_Mutation_p.C416F	NM_000390	NP_000381	P24386	RAE1_HUMAN	choroideremia isoform a	564					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(1)	1		all_lung(315;5.41e-06)				ATCATTATAACAGCTCCTGCT	0.368			NA											7	26					0.000442599	0.000483873	0.006214	1	0
CPXCR1	53336	broad.mit.edu	37	X	88008425	88008425	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:88008425C>A	uc004efd.3	+	3	269	c.10C>A	c.(10-12)CCT>ACT	p.P4T	CPXCR1_uc004efc.3_Missense_Mutation_p.P4T	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	4						intracellular	zinc ion binding			ovary(3)	3						GATGAGTTATCCTACTAAAGA	0.353			NA											3	9					0.00909568	0.00949057	0.009096	1	0
PCDH11X	27328	broad.mit.edu	37	X	91090514	91090514	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:91090514T>A	uc004efk.1	+	1	856	c.11T>A	c.(10-12)TTG>TAG	p.L4*	PCDH11X_uc004efl.1_Nonsense_Mutation_p.L4*|PCDH11X_uc004efo.1_Nonsense_Mutation_p.L4*|PCDH11X_uc010nmv.1_Nonsense_Mutation_p.L4*|PCDH11X_uc004efm.1_Nonsense_Mutation_p.L4*|PCDH11X_uc004efn.1_Nonsense_Mutation_p.L4*|PCDH11X_uc004efh.1_Nonsense_Mutation_p.L4*|PCDH11X_uc004efj.1_Nonsense_Mutation_p.L4*	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	4					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						ATGGACTTGTTGTCCGGGACG	0.463	NSCLC(38;925 1092 2571 38200 45895)		NA											33	41					0	0	0.009535	0	0
PCDH11X	27328	broad.mit.edu	37	X	91090671	91090671	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:91090671C>A	uc004efk.1	+	1	1013	c.168C>A	c.(166-168)TCC>TCA	p.S56S	PCDH11X_uc004efl.1_Silent_p.S56S|PCDH11X_uc004efo.1_Silent_p.S56S|PCDH11X_uc010nmv.1_Silent_p.S56S|PCDH11X_uc004efm.1_Silent_p.S56S|PCDH11X_uc004efn.1_Silent_p.S56S|PCDH11X_uc004efh.1_Silent_p.S56S|PCDH11X_uc004efj.1_Silent_p.S56S	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	56	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CAAACAAGTCCTTGACAACTG	0.463	NSCLC(38;925 1092 2571 38200 45895)		NA											26	47					3.28513e-13	4.81418e-13	0.003954	1	0
PCDH11X	27328	broad.mit.edu	37	X	91131909	91131909	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:91131909G>C	uc004efk.1	+	2	1515	c.670G>C	c.(670-672)GGT>CGT	p.G224R	PCDH11X_uc004efl.1_Missense_Mutation_p.G224R|PCDH11X_uc004efo.1_Missense_Mutation_p.G224R|PCDH11X_uc010nmv.1_Missense_Mutation_p.G224R|PCDH11X_uc004efm.1_Missense_Mutation_p.G224R|PCDH11X_uc004efn.1_Missense_Mutation_p.G224R|PCDH11X_uc004efh.1_Missense_Mutation_p.G224R|PCDH11X_uc004efj.1_Missense_Mutation_p.G224R	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	224	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						GGTTGAAGATGGTGGCTTTCC	0.413	NSCLC(38;925 1092 2571 38200 45895)		NA											40	118					0	0	0.00874	0	0
DIAPH2	1730	broad.mit.edu	37	X	95993694	95993694	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:95993694C>T	uc004efu.3	+	3	671	c.275C>T	c.(274-276)CCA>CTA	p.P92L	DIAPH2_uc004eft.3_Missense_Mutation_p.P92L|DIAPH2_uc004efs.2_Missense_Mutation_p.P92L	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	92					cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						GCAGCTCAGCCATTATATGAT	0.318			NA											14	46					0	0	0.001855	0	0
PCDH19	57526	broad.mit.edu	37	X	99662048	99662048	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:99662048G>T	uc010nmz.2	-	1	3224	c.1548C>A	c.(1546-1548)TAC>TAA	p.Y516*	PCDH19_uc004efw.3_Nonsense_Mutation_p.Y516*|PCDH19_uc004efx.3_Nonsense_Mutation_p.Y516*	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	516	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						ATCGCAGCGCGTAGATGTCGC	0.582			NA											22	64					2.32416e-17	3.75721e-17	0.002299	1	0
TNMD	64102	broad.mit.edu	37	X	99849302	99849302	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:99849302C>A	uc004efy.3	+	4	592	c.366C>A	c.(364-366)ATC>ATA	p.I122I	TNMD_uc004efz.2_Silent_p.I122I	NM_022144	NP_071427	Q9H2S6	TNMD_HUMAN	tenomodulin	122	Extracellular (Potential).|BRICHOS.					integral to membrane				central_nervous_system(1)	1						AATGTTTTATCAAAACTCAGA	0.328			NA											18	23					1.22574e-08	1.58379e-08	0.002299	1	0
CSTF2	1478	broad.mit.edu	37	X	100078976	100078976	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:100078976G>T	uc004egh.2	+	5	604	c.546G>T	c.(544-546)GTG>GTT	p.V182V	CSTF2_uc010nnd.2_Silent_p.V182V|CSTF2_uc004egi.2_Silent_p.V182V	NM_001325	NP_001316	P33240	CSTF2_HUMAN	cleavage stimulation factor subunit 2	182	Interactions with CSTF3 and SYMPK.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|protein binding|RNA binding			skin(1)	1						TGAGAATTGTGGATCCGGAAA	0.463			NA											26	67					3.73148e-12	5.32751e-12	0.007291	1	0
NOX1	27035	broad.mit.edu	37	X	100103634	100103634	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:100103634G>C	uc004egj.2	-	12	1759	c.1553C>G	c.(1552-1554)GCT>GGT	p.A518G	NOX1_uc004egl.3_Missense_Mutation_p.A469G|NOX1_uc010nne.2_Missense_Mutation_p.A481G	NM_007052	NP_008983	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1 isoform long	518	Interaction with NOXO1.|Cytoplasmic (Potential).				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			ovary(1)	1						GTGGGAGGTAGCTATTGTAGA	0.328			NA											13	58					0	0	0.00245	0	0
NXF5	55998	broad.mit.edu	37	X	101092590	101092590	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:101092590G>T	uc011mrk.1	-	15	1316	c.956C>A	c.(955-957)CCA>CAA	p.P319Q	NXF5_uc004eih.1_RNA|NXF5_uc004eii.1_RNA|NXF5_uc004eij.1_RNA|NXF5_uc004eik.1_RNA|NXF5_uc004eil.1_RNA	NM_032946	NP_116564	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	319	NTF2; truncated.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						CACGTTTCGTGGACATTTTGT	0.532			NA											32	70					1.06801e-11	1.50105e-11	0.009535	1	0
GPRASP1	9737	broad.mit.edu	37	X	101911151	101911151	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:101911151G>A	uc004ejj.3	+	5	3111	c.2310G>A	c.(2308-2310)AGG>AGA	p.R770R	GPRASP1_uc004eji.3_Silent_p.R770R|GPRASP1_uc010nod.2_Silent_p.R770R	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	770	Glu-rich.					cytoplasm	protein binding			ovary(1)|lung(1)	2						AAGAGTCCAGGCCAGAAGCTG	0.488			NA											24	72					0	0	0.00278	0	0
H2BFWT	158983	broad.mit.edu	37	X	103268102	103268102	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:103268102G>C	uc004elr.2	-	1	155	c.131C>G	c.(130-132)ACC>AGC	p.T44S		NM_001002916	NP_001002916	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	44					nucleosome assembly	nuclear membrane|nucleosome	DNA binding			ovary(1)	1						GGGCTCCTGGGTGATCAGCTG	0.627			NA											14	23					0	0	0.00245	0	0
COL4A5	1287	broad.mit.edu	37	X	107821200	107821200	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:107821200G>T	uc004enz.1	+	11	830	c.628G>T	c.(628-630)GGA>TGA	p.G210*	COL4A5_uc011mso.1_Nonsense_Mutation_p.G210*	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	210	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						TGGTCCACCAGGACTTCCAGG	0.294			NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				6	19					5.9392e-07	7.17882e-07	0.001168	1	0
CAPN6	827	broad.mit.edu	37	X	110494896	110494896	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:110494896A>T	uc004epc.1	-	6	942	c.774T>A	c.(772-774)GAT>GAA	p.D258E	CAPN6_uc011msu.1_Missense_Mutation_p.D3E	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	258	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						TTTTGCGAATATCAGTCATGG	0.453			NA											40	279					0	0	0.002522	0	0
LONRF3	79836	broad.mit.edu	37	X	118140177	118140177	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:118140177G>T	uc004eqw.2	+	6	1540	c.1509G>T	c.(1507-1509)TTG>TTT	p.L503F	LONRF3_uc004eqx.2_Missense_Mutation_p.L462F|LONRF3_uc004eqy.2_RNA|LONRF3_uc004eqz.2_Missense_Mutation_p.L247F	NM_001031855	NP_001027026	Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger	503	RING-type 2.				proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)	2						AGTGTCCATTGTGCAAAGACG	0.358			NA											53	131					8.44121e-28	1.55655e-27	0.00361	1	0
UBE2A	7319	broad.mit.edu	37	X	118717179	118717179	+	Silent	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:118717179T>A	uc004erl.2	+	6	596	c.420T>A	c.(418-420)CGT>CGA	p.R140R	UBE2A_uc004erm.2_Silent_p.R110R|UBE2A_uc004ern.2_RNA|UBE2A_uc004ero.2_RNA|UBE2A_uc004erp.2_Silent_p.R65R	NM_003336	NP_003327	P49459	UBE2A_HUMAN	ubiquitin-conjugating enzyme E2A isoform 1	140					histone H2A ubiquitination|positive regulation of cell proliferation|postreplication repair|protein autoubiquitination|protein K11-linked ubiquitination|protein K48-linked ubiquitination|response to UV|ubiquitin-dependent protein catabolic process		ATP binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity				0						ATGAAAAGCGTGTTTCTGCAA	0.438			NA						Direct_reversal_of_damage|Rad6_pathway					26	85					0	0	0.00632	0	0
ZBTB33	10009	broad.mit.edu	37	X	119388309	119388309	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:119388309G>T	uc004esn.1	+	2	1267	c.1039G>T	c.(1039-1041)GAC>TAC	p.D347Y	ZBTB33_uc010nqm.1_Missense_Mutation_p.D347Y	NM_006777	NP_006768	Q86T24	KAISO_HUMAN	kaiso	347					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CTCCAGTCCTGACTCGGCCGT	0.428			NA											43	72					1.76056e-25	3.21765e-25	0.002852	1	0
FAM70A	55026	broad.mit.edu	37	X	119438318	119438318	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:119438318G>T	uc004eso.3	-	2	314	c.87C>A	c.(85-87)TCC>TCA	p.S29S	FAM70A_uc004esp.3_Silent_p.S29S|FAM70A_uc010nqo.2_Silent_p.S29S	NM_017938	NP_060408	Q5JRV8	FA70A_HUMAN	hypothetical protein LOC55026 isoform 1	29						integral to membrane				lung(1)|breast(1)	2						TGACATAGATGGAGTTTCGTT	0.428			NA											26	58					1.17739e-12	1.6978e-12	0.005443	1	0
LAMP2	3920	broad.mit.edu	37	X	119582867	119582867	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:119582867G>C	uc004est.3	-	4	694	c.514C>G	c.(514-516)CTT>GTT	p.L172V	LAMP2_uc004ess.3_Missense_Mutation_p.L172V|LAMP2_uc011mtz.1_Missense_Mutation_p.L61V|LAMP2_uc011mua.1_Missense_Mutation_p.L125V|LAMP2_uc010nqp.1_Missense_Mutation_p.L172V	NM_002294	NP_002285	P13473	LAMP2_HUMAN	lysosomal-associated membrane protein 2 isoform	172	Lumenal (Potential).|First lumenal domain.				platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				ovary(1)	1						GCTTGTACAAGAACATCCCAG	0.358			NA											25	67					0	0	0.007291	0	0
CUL4B	8450	broad.mit.edu	37	X	119673217	119673217	+	Silent	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:119673217T>A	uc004esw.2	-	14	2138	c.1701A>T	c.(1699-1701)GTA>GTT	p.V567V	CUL4B_uc010nqq.2_Silent_p.V266V|CUL4B_uc004esv.2_Silent_p.V549V	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	567					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						GTTTTGAATCTACATACTTAG	0.348			NA											3	9					0	0	0.004672	0	0
GLUD2	2747	broad.mit.edu	37	X	120181692	120181692	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:120181692C>A	uc004eto.2	+	1	231	c.154C>A	c.(154-156)CAC>AAC	p.H52N		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	52					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	CGCCCGGCGCCACTACAGCGA	0.716			NA											19	26					3.62473e-10	4.8622e-10	0.001882	1	0
GLUD2	2747	broad.mit.edu	37	X	120183091	120183091	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:120183091C>A	uc004eto.2	+	1	1630	c.1553C>A	c.(1552-1554)GCC>GAC	p.A518D		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	518					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	GAGCGTTCTGCCAGGCAAATT	0.463			NA											24	49					7.4402e-23	1.31641e-22	0.003954	1	0
GRIA3	2892	broad.mit.edu	37	X	122387172	122387172	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:122387172G>T	uc004etq.3	+	4	580	c.287G>T	c.(286-288)AGA>ATA	p.R96I	GRIA3_uc004etr.3_Missense_Mutation_p.R96I|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Missense_Mutation_p.R80I	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	96	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	CAGTTCTCGAGAGGGGTGTAT	0.458			NA											24	76					2.79863e-10	3.76458e-10	0.004656	1	0
GRIA3	2892	broad.mit.edu	37	X	122616872	122616872	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:122616872G>T	uc004etq.3	+	16	2955	c.2662G>T	c.(2662-2664)GGA>TGA	p.G888*	GRIA3_uc004etr.3_Nonsense_Mutation_p.G888*|GRIA3_uc004ets.3_RNA	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	888	Cytoplasmic (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	CAACGTGTATGGAACAGAGAG	0.368			NA											26	66					1.39806e-14	2.13785e-14	0.008361	1	0
STAG2	10735	broad.mit.edu	37	X	123191804	123191804	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:123191804G>T	uc004etz.3	+	14	1732	c.1393G>T	c.(1393-1395)GTT>TTT	p.V465F	STAG2_uc004eua.2_Missense_Mutation_p.V465F|STAG2_uc004eub.2_Missense_Mutation_p.V465F|STAG2_uc004euc.2_Missense_Mutation_p.V465F|STAG2_uc004eud.2_Missense_Mutation_p.V465F|STAG2_uc004eue.2_Missense_Mutation_p.V465F	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	465					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TAAGACATTGGTTTTTTTCTT	0.348			NA											11	45					1.08611e-07	1.35482e-07	0.000978	1	0
STAG2	10735	broad.mit.edu	37	X	123202495	123202495	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:123202495G>T	uc004etz.3	+	23	2686	c.2347G>T	c.(2347-2349)GTT>TTT	p.V783F	STAG2_uc004eua.2_Missense_Mutation_p.V783F|STAG2_uc004eub.2_Missense_Mutation_p.V783F|STAG2_uc004euc.2_Missense_Mutation_p.V783F|STAG2_uc004eud.2_Missense_Mutation_p.V783F|STAG2_uc004eue.2_Missense_Mutation_p.V783F	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	783					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						GAATACTACTGTTAAGGAACA	0.294			NA											14	34					0.00316338	0.00336153	0.003163	1	0
DCAF12L1	139170	broad.mit.edu	37	X	125685683	125685683	+	Silent	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:125685683C>G	uc004eul.2	-	1	1160	c.909G>C	c.(907-909)CTG>CTC	p.L303L		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	303										skin(3)|ovary(1)	4						GGAAGTAGGGCAGCCTGATGG	0.597			NA											14	54					0	0	0.00245	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125686465	125686465	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:125686465T>A	uc004eul.2	-	1	378	c.127A>T	c.(127-129)AGG>TGG	p.R43W		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	43										skin(3)|ovary(1)	4						GCCGGCCGCCTCTGCCTCTTG	0.711			NA											11	49					0	0	0.00245	0	0
SMARCA1	6594	broad.mit.edu	37	X	128633753	128633753	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:128633753C>G	uc004eun.3	-	10	1346	c.1233G>C	c.(1231-1233)AAG>AAC	p.K411N	SMARCA1_uc004eup.3_Missense_Mutation_p.K411N|SMARCA1_uc011muk.1_Missense_Mutation_p.K411N|SMARCA1_uc011mul.1_Missense_Mutation_p.K411N	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated	411					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						TCTTTATTTCCTTTTTAGGTG	0.299			NA											44	71					0	0	0.00361	0	0
OCRL	4952	broad.mit.edu	37	X	128692702	128692702	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:128692702C>T	uc004euq.2	+	7	697	c.532C>T	c.(532-534)CCA>TCA	p.P178S	OCRL_uc004eur.2_Missense_Mutation_p.P178S	NM_000276	NP_000267	Q01968	OCRL_HUMAN	phosphatidylinositol polyphosphate 5-phosphatase	178					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			lung(2)|ovary(1)|kidney(1)	4						TCGGGAACCCCCACCTCCACC	0.348			NA											17	41					0	0	0.00499	0	0
UTP14A	10813	broad.mit.edu	37	X	129063311	129063311	+	Splice_Site	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:129063311G>T	uc004euz.2	+	15	2072	c.2044_splice	c.e15-1	p.V682_splice	UTP14A_uc011mup.1_Splice_Site_p.V630_splice|UTP14A_uc011muq.1_Splice_Site_p.V628_splice	NM_006649	NP_006640	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,						rRNA processing	nucleolus|small-subunit processome	protein binding			ovary(2)	2						TTCCTTTCCAGGTACGAGTGC	0.493			NA											28	70					4.43304e-23	7.88217e-23	0.00632	1	0
SLC25A14	9016	broad.mit.edu	37	X	129499558	129499558	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:129499558C>T	uc004evn.1	+	9	976	c.763C>T	c.(763-765)CCG>TCG	p.P255S	SLC25A14_uc011mut.1_3'UTR|SLC25A14_uc011muu.1_3'UTR|SLC25A14_uc010nrg.2_3'UTR|SLC25A14_uc004evo.1_Missense_Mutation_p.P76S|SLC25A14_uc004evp.1_Missense_Mutation_p.P255S|SLC25A14_uc004evq.1_Missense_Mutation_p.P252S|SLC25A14_uc004evr.1_Missense_Mutation_p.P283S	NM_003951	NP_003942	O95258	UCP5_HUMAN	solute carrier family 25, member 14 isoform	255	Solcar 3.|Helical; Name=5; (Potential).				aerobic respiration|mitochondrial transport	integral to plasma membrane|mitochondrial inner membrane	binding			ovary(1)	1						GGCCTCCAACCCGGTTGATGT	0.478			NA											33	90					0	0	0.003755	0	0
ENOX2	10495	broad.mit.edu	37	X	129759372	129759372	+	Silent	SNP	G	G	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:129759372G>A	uc004evw.2	-	16	2167	c.1749C>T	c.(1747-1749)ACC>ACT	p.T583T	ENOX2_uc004evx.2_Silent_p.T554T|ENOX2_uc004evy.2_Silent_p.T554T|ENOX2_uc004evv.2_Silent_p.T408T	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	583					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						CCTGCTTGAAGGTATGCTGGA	0.468	Ovarian(101;828 1506 2951 9500 35258)		NA											10	27					0	0	0.008291	0	0
ENOX2	10495	broad.mit.edu	37	X	129799677	129799677	+	Silent	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:129799677T>A	uc004evw.2	-	10	1459	c.1041A>T	c.(1039-1041)GCA>GCT	p.A347A	ENOX2_uc004evx.2_Silent_p.A318A|ENOX2_uc004evy.2_Silent_p.A318A|ENOX2_uc004evv.2_Silent_p.A174A	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	347					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						AGTGGTCCCATGCCTTCTGCT	0.522	Ovarian(101;828 1506 2951 9500 35258)		NA											5	15					0	0	0.001168	0	0
IGSF1	3547	broad.mit.edu	37	X	130409233	130409233	+	Missense_Mutation	SNP	G	G	A	rs35967907		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:130409233G>A	uc004ewd.2	-	17	3450	c.3212C>T	c.(3211-3213)GCC>GTC	p.A1071V	IGSF1_uc004ewe.3_Missense_Mutation_p.A1065V|IGSF1_uc004ewf.2_Missense_Mutation_p.A1051V	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	1071	Extracellular (Potential).|Ig-like C2-type 11.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						ACCAGGCTGGGCTAATAGGCT	0.537			NA											34	80					0	0	0.004289	0	0
GPC4	2239	broad.mit.edu	37	X	132548940	132548941	+	Missense_Mutation	DNP	GG	GG	TT	rs150450966	byFrequency	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:132548940_132548941GG>TT	uc004exc.1	-	1	265_266	c.53_54CC>AA	c.(52-54)GCC>GAA	p.A18E	GPC4_uc011mvg.1_5'Flank	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	18					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					CCAGCAGCGCGGCGCTGAGCAC	0.644			NA											11	22					0	0	0.004672	0	0
MOSPD1	56180	broad.mit.edu	37	X	134025544	134025544	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:134025544C>A	uc004eyb.2	-	5	762	c.575G>T	c.(574-576)AGT>ATT	p.S192I	MOSPD1_uc004eya.2_Intron|MOSPD1_uc010nrv.2_RNA	NM_019556	NP_062456	Q9UJG1	MSPD1_HUMAN	motile sperm domain containing 1	192	Helical; (Potential).				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	integral to membrane|nucleus|perinuclear region of cytoplasm	structural molecule activity			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(192;0.000127)					TTGATTCACACTTAAGTGGAG	0.468			NA											38	98					4.0492e-12	5.77542e-12	0.006999	1	0
FHL1	2273	broad.mit.edu	37	X	135288703	135288703	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:135288703A>T	uc004ezo.2	+	2	212	c.112A>T	c.(112-114)AAC>TAC	p.N38Y	FHL1_uc010nrz.2_Missense_Mutation_p.N38Y|FHL1_uc004ezm.2_Intron|FHL1_uc004ezl.2_Missense_Mutation_p.N38Y|FHL1_uc004ezq.2_Missense_Mutation_p.N38Y|FHL1_uc011mvy.1_Missense_Mutation_p.N38Y|FHL1_uc011mvz.1_Missense_Mutation_p.N38Y|FHL1_uc004ezn.2_Missense_Mutation_p.N38Y|FHL1_uc011mwa.1_Missense_Mutation_p.N67Y|FHL1_uc011mwb.1_RNA|FHL1_uc004ezp.2_Missense_Mutation_p.N54Y|FHL1_uc004ezr.2_5'Flank	NM_001159702	NP_001153174	Q13642	FHL1_HUMAN	four and a half LIM domains 1 isoform 1	38					cell differentiation|cell growth|muscle organ development|organ morphogenesis	cytosol|nucleus|plasma membrane	protein binding|zinc ion binding				0	Acute lymphoblastic leukemia(192;0.000127)					GTTCTGTGCCAACACCTGTGT	0.552			NA											37	114					0	0	0.006999	0	0
HTATSF1	27336	broad.mit.edu	37	X	135593100	135593100	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:135593100C>G	uc004ezw.2	+	10	1618	c.1196C>G	c.(1195-1197)GCA>GGA	p.A399G	HTATSF1_uc004ezx.2_Missense_Mutation_p.A399G	NM_001163280	NP_001156752	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	399	Mediates interaction with the P-TEFb complex.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CCTTCTAGAGCAAGGCATTTT	0.483			NA											31	91					0	0	0.002445	0	0
GPR101	83550	broad.mit.edu	37	X	136112472	136112472	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:136112472A>T	uc011mwh.1	-	1	1362	c.1362T>A	c.(1360-1362)TAT>TAA	p.Y454*		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	454	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					GCATGTAGCCATAGACATAGG	0.512			NA											31	52					0	0	0.002836	0	0
F9	2158	broad.mit.edu	37	X	138642944	138642944	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:138642944C>A	uc004fas.1	+	7	797	c.768C>A	c.(766-768)ATC>ATA	p.I256I	F9_uc004fat.1_Silent_p.I218I	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	256	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	GAGGCTCTATCGTTAATGAAA	0.333			NA											37	78					9.42957e-07	1.13218e-06	0.007835	1	0
F9	2158	broad.mit.edu	37	X	138644187	138644187	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:138644187C>A	uc004fas.1	+	8	1372	c.1343C>A	c.(1342-1344)TCC>TAC	p.S448Y	F9_uc004fat.1_Missense_Mutation_p.S410Y	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	448	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	ACCAAGGTATCCCGGTATGTC	0.378			NA											20	43					3.62473e-10	4.8622e-10	0.001882	1	0
MAGEC1	9947	broad.mit.edu	37	X	140995862	140995862	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:140995862T>A	uc004fbt.2	+	4	2958	c.2672T>A	c.(2671-2673)TTG>TAG	p.L891*	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	891							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGTGATTCCTTGACAGACAGC	0.473			NA								HNSCC(15;0.026)			52	131					0	0	0.00361	0	0
MAGEA11	4110	broad.mit.edu	37	X	148797683	148797683	+	Silent	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:148797683C>A	uc004fdq.2	+	5	639	c.537C>A	c.(535-537)TCC>TCA	p.S179S	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Silent_p.S150S	NM_005366	NP_005357	P43364	MAGAB_HUMAN	melanoma antigen family A, 11 isoform a	179						cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					AGGAAGAGTCCTTCTCTCCCA	0.562			NA											16	29					2.35188e-11	3.27673e-11	0.006122	1	0
MAMLD1	10046	broad.mit.edu	37	X	149638775	149638775	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:149638775G>T	uc004fee.1	+	3	1006	c.930G>T	c.(928-930)TTG>TTT	p.L310F	MAMLD1_uc011mxt.1_Missense_Mutation_p.L272F|MAMLD1_uc011mxu.1_Missense_Mutation_p.L285F|MAMLD1_uc011mxv.1_Missense_Mutation_p.L285F|MAMLD1_uc011mxw.1_Missense_Mutation_p.L237F	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	310					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					TGAAGGCGTTGGCAGCCAGCA	0.632			NA											14	41					4.36969e-10	5.83435e-10	0.001855	1	0
MAMLD1	10046	broad.mit.edu	37	X	149639337	149639337	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:149639337C>A	uc004fee.1	+	3	1568	c.1492C>A	c.(1492-1494)CAG>AAG	p.Q498K	MAMLD1_uc011mxt.1_Missense_Mutation_p.Q460K|MAMLD1_uc011mxu.1_Missense_Mutation_p.Q473K|MAMLD1_uc011mxv.1_Missense_Mutation_p.Q473K|MAMLD1_uc011mxw.1_Missense_Mutation_p.Q425K	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	498	Poly-Gln.				male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					gcagcagcagcagcagcagca	0.448			NA											11	37					0.00829132	0.00870166	0.008291	1	0
GABRQ	55879	broad.mit.edu	37	X	151814002	151814002	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:151814002G>T	uc004ffp.1	+	3	273	c.253G>T	c.(253-255)GTG>TTG	p.V85L		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	85	Extracellular (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCCTGTGCCTGTGAGAATATC	0.323			NA											20	49					3.62473e-10	4.8622e-10	0.001882	1	0
ZNF275	10838	broad.mit.edu	37	X	152612745	152612745	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:152612745G>T	uc004fhg.1	+	4	779	c.602G>T	c.(601-603)AGG>ATG	p.R201M	ZNF275_uc011mym.1_Missense_Mutation_p.R201M|ZNF275_uc011myn.1_Missense_Mutation_p.R138M			A6NFS0	A6NFS0_HUMAN	SubName: Full=cDNA FLJ16723 fis, clone UTERU3004418, highly similar to Zinc finger protein 275; SubName: Full=Putative uncharacterized protein ZNF275;	201						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGCATCTGAGGGTCCACAGC	0.547			NA											41	52					2.13384e-23	3.80816e-23	0.00361	1	0
BCAP31	10134	broad.mit.edu	37	X	152981071	152981071	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:152981071C>T	uc011myz.1	-	4	423	c.267G>A	c.(265-267)ATG>ATA	p.M89I	BCAP31_uc011myy.1_Missense_Mutation_p.M1I|BCAP31_uc004fid.2_Missense_Mutation_p.M156I|BCAP31_uc011mza.1_Missense_Mutation_p.M89I|BCAP31_uc004fie.2_Missense_Mutation_p.M89I	NM_001139441	NP_001132913	P51572	BAP31_HUMAN	B-cell receptor-associated protein 31 isoform b	89	Lumenal (Potential).				cellular component disassembly involved in apoptosis|immune response|intracellular protein transport|vesicle-mediated transport	cytosol|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|integral to plasma membrane	receptor binding				0	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGAAGTGCTCCATGGCCCCGG	0.552			NA											26	56					0	0	0.00333	0	0
PLXNB3	5365	broad.mit.edu	37	X	153039404	153039404	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:153039404T>G	uc004fii.2	+	20	3544	c.3370T>G	c.(3370-3372)TTC>GTC	p.F1124V	PLXNB3_uc010nuk.2_Missense_Mutation_p.F1147V|PLXNB3_uc011mzd.1_Missense_Mutation_p.F763V|PLXNB3_uc004fij.1_5'Flank|SRPK3_uc004fik.2_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	1124	IPT/TIG 3.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GCGGGTCTTCTTCACCCTAGA	0.672			NA											13	61					0	0	0.003163	0	0
L1CAM	3897	broad.mit.edu	37	X	153132121	153132121	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:153132121C>A	uc004fjb.2	-	18	2522	c.2414G>T	c.(2413-2415)GGC>GTC	p.G805V	L1CAM_uc004fjc.2_Missense_Mutation_p.G805V|L1CAM_uc010nuo.2_Missense_Mutation_p.G800V	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	805	Extracellular (Potential).|Fibronectin type-III 2.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCCAGAGTAGCCGATAGTGAC	0.612			NA											17	54					1.33834e-09	1.76406e-09	0.007413	1	0
L1CAM	3897	broad.mit.edu	37	X	153132925	153132925	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:153132925T>C	uc004fjb.2	-	16	2131	c.2023A>G	c.(2023-2025)ACC>GCC	p.T675A	L1CAM_uc004fjc.2_Missense_Mutation_p.T675A|L1CAM_uc010nuo.2_Missense_Mutation_p.T670A	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	675	Fibronectin type-III 1.|Extracellular (Potential).				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TTGAGGGTGGTAGAGGTCTGG	0.512			NA											39	139					0	0	0.009718	0	0
TMEM187	8269	broad.mit.edu	37	X	153247610	153247610	+	Missense_Mutation	SNP	G	G	A	rs139864308	byFrequency	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:153247610G>A	uc004fjq.2	+	2	631	c.97G>A	c.(97-99)GTG>ATG	p.V33M	hsa-mir-3202-2|MI0014253_5'Flank	NM_003492	NP_003483	Q14656	TM187_HUMAN	transmembrane protein 187	33						integral to membrane|transport vesicle					0	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGTGTTTCCGTGCAAGTGGG	0.637			NA											20	58					0	0	0.00278	0	0
GDI1	2664	broad.mit.edu	37	X	153670947	153670947	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:153670947G>T	uc004fli.3	+	11	1614	c.1272G>T	c.(1270-1272)ATG>ATT	p.M424I	GDI1_uc004flj.2_Missense_Mutation_p.M89I|FAM50A_uc004fll.3_5'Flank	NM_001493	NP_001484	P31150	GDIA_HUMAN	GDP dissociation inhibitor 1	424					protein transport|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|midbody	GTPase activator activity|protein binding				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACAAACGCATGGCTGGCACGG	0.547			NA											19	79					1.40151e-16	2.23312e-16	0.010504	1	0
F8	2157	broad.mit.edu	37	X	154157794	154157794	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:154157794G>T	uc004fmt.2	-	14	4442	c.4271C>A	c.(4270-4272)ACC>AAC	p.T1424N		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	1424	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TAGGACCCTGGTCAGATATAT	0.418			NA											44	74					6.07928e-31	1.13406e-30	0.009718	1	0
RAB39B	116442	broad.mit.edu	37	X	154493454	154493454	+	Silent	SNP	G	G	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:154493454G>T	uc004fne.2	-	1	399	c.120C>A	c.(118-120)ACC>ACA	p.T40T		NM_171998	NP_741995	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	40	Effector region (By similarity).				protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CCACCCCCACGGTGGGGTCAG	0.592			NA											29	53					8.58068e-18	1.40287e-17	0.007291	1	0
AK3L1	205	broad.mit.edu	37	1	65614125	65614132	+	Frame_Shift_Del	DEL	GGCCGCCC	GGCCGCCC	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	GGCCGCCC	GGCCGCCC	-	-	GGCCGCCC	GGCCGCCC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:65614125_65614132delGGCCGCCC	uc001dby.2	+	2	282_289	c.35_42delGGCCGCCC	c.(34-42)GGGCCGCCCfs	p.G12fs	AK3L1_uc009wan.2_Intron|AK3L1_uc001dbz.2_Frame_Shift_Del_p.G12fs|AK3L1_uc001dca.2_Frame_Shift_Del_p.G12fs	NM_203464	NP_982289	P27144	KAD4_HUMAN	adenylate kinase 3-like 1 isoform 7	12_14	ATP.					mitochondrial matrix	adenylate kinase activity|ATP binding|GTP binding				0						GTCATCCTCGGGCCGCCCGGCTCGGGCA	0.688			NA											4	4	---	---	---	---	NA	NA	NA	NA	NA
IFI44	10561	broad.mit.edu	37	1	79120772	79120773	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:79120772_79120773insT	uc001dip.3	+	4	692_693	c.568_569insT	c.(568-570)CTGfs	p.L190fs	IFI44_uc010orr.1_Frame_Shift_Ins_p.L190fs|IFI44_uc010ors.1_5'UTR	NM_006417	NP_006408	Q8TCB0	IFI44_HUMAN	interferon-induced, hepatitis C-associated	190					response to virus	cytoplasm				ovary(1)|central_nervous_system(1)	2						AATACGAATTCTGCTGCTGGGT	0.455			NA											21	44	---	---	---	---	NA	NA	NA	NA	NA
NPR1	4881	broad.mit.edu	37	1	153656220	153656220	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:153656220delC	uc001fcs.3	+	7	1825	c.1404delC	c.(1402-1404)CACfs	p.H468fs	NPR1_uc010pdz.1_Frame_Shift_Del_p.H214fs|NPR1_uc010pea.1_5'Flank	NM_000906	NP_000897	P16066	ANPRA_HUMAN	natriuretic peptide receptor 1 precursor	468	Extracellular (Potential).				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			ovary(3)|lung(2)|stomach(1)|breast(1)	7	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	ctGCAGATCACCTTTCCACCC	0.363	Pancreas(141;1349 1870 15144 15830 40702)		NA											30	59	---	---	---	---	NA	NA	NA	NA	NA
RAB25	57111	broad.mit.edu	37	1	156039504	156039507	+	Frame_Shift_Del	DEL	CTAC	CTAC	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	CTAC	CTAC	-	-	CTAC	CTAC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:156039504_156039507delCTAC	uc001fnc.2	+	4	702_705	c.476_479delCTAC	c.(475-480)TCTACCfs	p.S159fs		NM_020387	NP_065120	P57735	RAB25_HUMAN	RAB25	159_160					positive regulation of cell proliferation|protein transport|pseudopodium organization|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|pseudopodium membrane	GTP binding|identical protein binding				0	Hepatocellular(266;0.158)|all_neural(408;0.195)					GCCCTGGACTCTACCAATGTTGAG	0.471			NA											151	220	---	---	---	---	NA	NA	NA	NA	NA
RYR2	6262	broad.mit.edu	37	1	237796954	237796954	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:237796954delA	uc001hyl.1	+	43	6752	c.6632delA	c.(6631-6633)CAAfs	p.Q2211fs		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2211	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGGCAGAATCAAAAAGCTATG	0.358			NA											20	83	---	---	---	---	NA	NA	NA	NA	NA
OR2T34	127068	broad.mit.edu	37	1	248738019	248738019	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr1:248738019delT	uc001iep.1	-	1	40	c.40delA	c.(40-42)AGCfs	p.S14fs		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AAATCAGTGCTTGCTGTTTGA	0.463			NA											9	49	---	---	---	---	NA	NA	NA	NA	NA
ATRNL1	26033	broad.mit.edu	37	10	117027900	117027900	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr10:117027900delG	uc001lcg.2	+	13	2465	c.2079delG	c.(2077-2079)TCGfs	p.S693fs		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	693	PSI 2.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AATGCATTTCGGCAAATAGTA	0.403			NA											15	56	---	---	---	---	NA	NA	NA	NA	NA
OR4A5	81318	broad.mit.edu	37	11	51411649	51411650	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:51411649_51411650insA	uc001nhi.1	-	1	746_747	c.746_747insT	c.(745-747)GTAfs	p.V249fs		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	249	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				AAATACAGGGTACAAAAAAGAG	0.406			NA											25	47	---	---	---	---	NA	NA	NA	NA	NA
OR8K1	390157	broad.mit.edu	37	11	56114033	56114035	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	CTT	CTT	-	-	CTT	CTT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr11:56114033_56114035delCTT	uc010rjg.1	+	1	519_521	c.519_521delCTT	c.(517-522)TCCTTC>TCC	p.F174del		NM_001002907	NP_001002907	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K,	174	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					TTAAACTGTCCTTCTGTGGCTCA	0.355			NA								HNSCC(65;0.19)			21	79	---	---	---	---	NA	NA	NA	NA	NA
KIAA1467	57613	broad.mit.edu	37	12	13211385	13211386	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:13211385_13211386insT	uc001rbi.2	+	3	457_458	c.434_435insT	c.(433-435)GGTfs	p.G145fs	KIAA1467_uc009zhx.1_RNA	NM_020853	NP_065904	A2RU67	K1467_HUMAN	hypothetical protein LOC57613	145						integral to membrane				central_nervous_system(2)|skin(1)	3		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		TGTATAACAGGTGGGGACCTGT	0.426			NA											79	275	---	---	---	---	NA	NA	NA	NA	NA
GRIN2B	2904	broad.mit.edu	37	12	13720177	13720177	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:13720177delC	uc001rbt.2	-	12	2559	c.2380delG	c.(2380-2382)GCTfs	p.A794fs		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	794	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGCCAGAGAGCTTCCAGTTCT	0.328			NA											25	23	---	---	---	---	NA	NA	NA	NA	NA
LIN7A	8825	broad.mit.edu	37	12	81239540	81239540	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:81239540delC	uc001szj.1	-	4	645	c.452delG	c.(451-453)AGAfs	p.R151fs	LIN7A_uc001szk.1_RNA	NM_004664	NP_004655	O14910	LIN7A_HUMAN	lin-7 homolog A	151	PDZ.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			ovary(1)|skin(1)	2						CTGGTCTCCTCTTTTGAGGCC	0.428			NA											32	48	---	---	---	---	NA	NA	NA	NA	NA
CUX2	23316	broad.mit.edu	37	12	111757899	111757899	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr12:111757899delA	uc001tsa.1	+	17	2239	c.2086delA	c.(2086-2088)ATCfs	p.I696fs		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	696	Potential.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						CATCAAGAGCATCCTGGAGCA	0.726			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
PARP4	143	broad.mit.edu	37	13	25009604	25009605	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr13:25009604_25009605insA	uc001upl.2	-	31	3780_3781	c.3674_3675insT	c.(3673-3675)TTAfs	p.L1225fs		NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1225					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		CAGAGGATGCTAAAAGAGACTG	0.376			NA											11	63	---	---	---	---	NA	NA	NA	NA	NA
FNDC3A	22862	broad.mit.edu	37	13	49710605	49710605	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr13:49710605delA	uc001vcm.2	+	6	933	c.628delA	c.(628-630)AAAfs	p.K210fs	FNDC3A_uc001vcl.1_Frame_Shift_Del_p.K210fs|FNDC3A_uc001vcn.2_Frame_Shift_Del_p.K210fs|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcp.1_Frame_Shift_Del_p.K154fs|FNDC3A_uc001vcq.2_Frame_Shift_Del_p.K154fs	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	210						Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		ATCACCCCAGAAATGCCCTTC	0.393			NA											47	39	---	---	---	---	NA	NA	NA	NA	NA
MAP4K5	11183	broad.mit.edu	37	14	50952308	50952308	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr14:50952308delC	uc001wya.2	-	5	630	c.310delG	c.(310-312)GATfs	p.D104fs	MAP4K5_uc001wyb.2_Frame_Shift_Del_p.D104fs|MAP4K5_uc010anv.1_Frame_Shift_Del_p.D104fs	NM_006575	NP_006566	Q9Y4K4	M4K5_HUMAN	mitogen-activated protein kinase kinase kinase	104	Protein kinase.				activation of JUN kinase activity	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(1)	1	all_epithelial(31;0.000415)|Breast(41;0.0102)					TGGTAAATATCTTGAAGTGAT	0.299			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
MGA	23269	broad.mit.edu	37	15	41961546	41961547	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:41961546_41961547insT	uc001zog.1	+	2	545_546	c.454_455insT	c.(454-456)GTTfs	p.V152fs	MGA_uc010ucy.1_Frame_Shift_Ins_p.V152fs|MGA_uc010ucz.1_Frame_Shift_Ins_p.V152fs	NM_001080541	NP_001074010	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 2	152	T-box.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TGAACCTCATGTTTTGGGGAGG	0.401			NA											91	97	---	---	---	---	NA	NA	NA	NA	NA
SLC24A5	283652	broad.mit.edu	37	15	48434470	48434471	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr15:48434470_48434471insA	uc001zwe.2	+	9	1498_1499	c.1425_1426insA	c.(1423-1428)TACTTGfs	p.Y475fs	SLC24A5_uc010bel.2_Frame_Shift_Ins_p.Y415fs|MYEF2_uc001zwg.3_3'UTR|MYEF2_uc001zwh.3_3'UTR|MYEF2_uc001zwi.3_3'UTR|MYEF2_uc001zwj.3_3'UTR|SLC24A5_uc001zwk.2_Frame_Shift_Ins_p.Y106fs	NM_205850	NP_995322	Q71RS6	NCKX5_HUMAN	solute carrier family 24, member 5 precursor	475_476	Helical; Name=11; (Potential).				response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity				0		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		TATTATCATACTTGGGGCTTGC	0.337			NA											34	25	---	---	---	---	NA	NA	NA	NA	NA
ALKBH6	84964	broad.mit.edu	37	19	36504245	36504245	+	Splice_Site	DEL	C	C	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr19:36504245delC	uc002oct.2	-	2	154	c.54_splice	c.e2+1	p.Q18_splice	ALKBH6_uc002ocv.1_Splice_Site_p.Q46_splice|ALKBH6_uc002ocx.1_Splice_Site|ALKBH6_uc002ocw.1_Splice_Site_p.Q46_splice|ALKBH6_uc010eeo.1_Splice_Site_p.Q18_splice|ALKBH6_uc010eep.1_Splice_Site_p.Q46_splice|uc002ocy.2_5'Flank	NM_032878	NP_116267	Q3KRA9	ALKB6_HUMAN	alkB, alkylation repair homolog 6 isoform 2							cytoplasm|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0	all_lung(56;1.35e-06)|Lung NSC(56;2.15e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GTTCTGACAACCTGCTCCACT	0.557			NA											26	47	---	---	---	---	NA	NA	NA	NA	NA
PLB1	151056	broad.mit.edu	37	2	28766124	28766125	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:28766124_28766125insG	uc002rmb.1	+	14	925_926	c.925_926insG	c.(925-927)TGGfs	p.W309fs	PLB1_uc010ezj.1_Frame_Shift_Ins_p.W320fs	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	309	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|1.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					CTGGCATCTCTGGAATAGGATG	0.614			NA											7	17	---	---	---	---	NA	NA	NA	NA	NA
CLIP4	79745	broad.mit.edu	37	2	29386781	29386782	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:29386781_29386782delCA	uc002rmv.2	+	13	1858_1859	c.1619_1620delCA	c.(1618-1620)CCAfs	p.P540fs	CLIP4_uc002rmu.2_Frame_Shift_Del_p.P540fs|CLIP4_uc002rmw.2_RNA	NM_024692	NP_078968	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family,	540	CAP-Gly 2.									ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					AGCTGTTCTCCAAGATATGGAA	0.371			NA											19	106	---	---	---	---	NA	NA	NA	NA	NA
TCF7L1	83439	broad.mit.edu	37	2	85531103	85531103	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:85531103delC	uc002soy.2	+	6	818	c.744delC	c.(742-744)CTCfs	p.L248fs		NM_031283	NP_112573	Q9HCS4	TF7L1_HUMAN	HMG-box transcription factor TCF-3	248	Pro-rich.				chromatin organization|regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|breast(1)|central_nervous_system(1)	3						CCCACCCCCTCGGCTGGCTCG	0.647			NA											24	55	---	---	---	---	NA	NA	NA	NA	NA
SLC9A4	389015	broad.mit.edu	37	2	103124574	103124574	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:103124574delG	uc002tbz.3	+	5	1692	c.1235delG	c.(1234-1236)CGGfs	p.R412fs		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	412	Extracellular (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						AACCAGTTTCGGACTTTCCCC	0.448			NA											29	115	---	---	---	---	NA	NA	NA	NA	NA
GALNT13	114805	broad.mit.edu	37	2	155102404	155102404	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:155102404delG	uc002tyr.3	+	7	1333	c.766delG	c.(766-768)GGGfs	p.G256fs	GALNT13_uc002tyt.3_Frame_Shift_Del_p.G256fs|GALNT13_uc010foc.1_Frame_Shift_Del_p.G75fs|GALNT13_uc010fod.2_Frame_Shift_Del_p.G9fs	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	256	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CATGACTTATGGGGGTTTTAA	0.413			NA											26	71	---	---	---	---	NA	NA	NA	NA	NA
DNAH7	56171	broad.mit.edu	37	2	196825599	196825600	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr2:196825599_196825600insT	uc002utj.3	-	18	2376_2377	c.2275_2276insA	c.(2275-2277)ATCfs	p.I759fs		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	759	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GCCATCTTGGATTTTTTTACGT	0.366			NA											18	88	---	---	---	---	NA	NA	NA	NA	NA
HAO1	54363	broad.mit.edu	37	20	7895047	7895048	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:7895047_7895048insG	uc002wmw.1	-	3	332_333	c.308_309insC	c.(307-309)ACGfs	p.T103fs	HAO1_uc010gbu.2_Frame_Shift_Ins_p.T103fs	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	103	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						ACATCATGCCCGTTCCCAGGGA	0.51			NA											8	17	---	---	---	---	NA	NA	NA	NA	NA
LAMA5	3911	broad.mit.edu	37	20	60887362	60887363	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr20:60887362_60887363delGC	uc002ycq.2	-	69	9437_9438	c.9370_9371delGC	c.(9370-9372)GCCfs	p.A3124fs		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	3124	Laminin G-like 3.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAAAGTCATGGCGCGCCCCACC	0.693			NA											7	18	---	---	---	---	NA	NA	NA	NA	NA
MOV10L1	54456	broad.mit.edu	37	22	50553643	50553643	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr22:50553643delA	uc003bjj.2	+	8	1310	c.1227delA	c.(1225-1227)GGAfs	p.G409fs	MOV10L1_uc003bjk.3_Frame_Shift_Del_p.G409fs|MOV10L1_uc011arp.1_Frame_Shift_Del_p.G389fs|MOV10L1_uc011arq.1_Frame_Shift_Del_p.G170fs|MOV10L1_uc010hao.1_RNA	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	409					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		CTCCAGGGGGAAAAACCTTCA	0.483			NA											30	181	---	---	---	---	NA	NA	NA	NA	NA
KCNH8	131096	broad.mit.edu	37	3	19295164	19295164	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:19295164delC	uc003cbk.1	+	2	290	c.95delC	c.(94-96)GCCfs	p.A32fs	KCNH8_uc011awe.1_Frame_Shift_Del_p.A32fs|KCNH8_uc010hex.1_5'UTR	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	32	Cytoplasmic (Potential).|PAS.					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						TTCATCCTTGCCAATGCCCAG	0.423	NSCLC(124;1625 1765 8018 24930 42026)		NA											59	41	---	---	---	---	NA	NA	NA	NA	NA
TGM4	7047	broad.mit.edu	37	3	44945424	44945425	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:44945424_44945425insA	uc003coc.3	+	9	1093_1094	c.1020_1021insA	c.(1018-1023)CCCAAGfs	p.P340fs		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	340_341					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	CGGATCTGCCCAAGGGCTACGA	0.634			NA											54	36	---	---	---	---	NA	NA	NA	NA	NA
ZIC1	7545	broad.mit.edu	37	3	147128309	147128309	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:147128309delC	uc003ewe.2	+	1	1129	c.410delC	c.(409-411)GCCfs	p.A137fs		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	137					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CACACGGACGCCGCGGGCCAC	0.721			NA											19	10	---	---	---	---	NA	NA	NA	NA	NA
SERPINI2	5276	broad.mit.edu	37	3	167189475	167189475	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr3:167189475delG	uc003fer.1	-	1	206	c.148delC	c.(148-150)CTTfs	p.L50fs	SERPINI2_uc003fes.1_Frame_Shift_Del_p.L60fs|SERPINI2_uc003fet.1_Frame_Shift_Del_p.L50fs	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	50					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						GTTATTCCAAGGGGTGAAAAT	0.398			NA											49	89	---	---	---	---	NA	NA	NA	NA	NA
AMTN	401138	broad.mit.edu	37	4	71394929	71394930	+	Splice_Site	INS	-	-	A			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr4:71394929_71394930insA	uc003hfk.1	+	7	446	c.357_splice	c.e7+2	p.L119_splice	AMTN_uc010ihy.1_Splice_Site_p.L118_splice	NM_212557	NP_997722	Q6UX39	AMTN_HUMAN	amelotin precursor						biomineral tissue development|cell adhesion|odontogenesis of dentine-containing tooth	basal lamina|cell-cell junction				large_intestine(1)|central_nervous_system(1)	2			Lung(101;0.235)			GAGGAATTGGTAAAAAAAATAA	0.267			NA											12	13	---	---	---	---	NA	NA	NA	NA	NA
SLC9A3	6550	broad.mit.edu	37	5	491985	491985	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:491985delC	uc003jbe.2	-	2	525	c.413delG	c.(412-414)GGCfs	p.G138fs	SLC9A3_uc011clx.1_Frame_Shift_Del_p.G138fs	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	138	Cytoplasmic (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CCCCAGGTTGCCGAAGAAGAG	0.632			NA											4	9	---	---	---	---	NA	NA	NA	NA	NA
ARSK	153642	broad.mit.edu	37	5	94927329	94927329	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr5:94927329delG	uc003kld.2	+	6	1254	c.1096delG	c.(1096-1098)GATfs	p.D366fs	ARSK_uc010jbg.2_Frame_Shift_Del_p.D207fs|ARSK_uc011cum.1_RNA	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	arylsulfatase K precursor	366						extracellular region	arylsulfatase activity|metal ion binding			pancreas(1)	1		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		TACCATGCTTGGTAAGTAATG	0.393			NA											27	43	---	---	---	---	NA	NA	NA	NA	NA
TNXB	7148	broad.mit.edu	37	6	32026081	32026081	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:32026081delC	uc003nzl.2	-	22	7781	c.7579delG	c.(7579-7581)GAGfs	p.E2527fs		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2587	Fibronectin type-III 18.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						ACTGTCAGCTCCCCCAGGAGA	0.627			NA											12	51	---	---	---	---	NA	NA	NA	NA	NA
RBM16	22828	broad.mit.edu	37	6	155154520	155154520	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr6:155154520delG	uc003qqa.2	+	21	4039	c.3807delG	c.(3805-3807)GAGfs	p.E1269fs	TIAM2_uc003qqb.2_5'UTR|RBM16_uc011efj.1_Frame_Shift_Del_p.E1335fs|RBM16_uc011efk.1_Frame_Shift_Del_p.E1314fs|RBM16_uc003qpz.2_Frame_Shift_Del_p.E1269fs	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	1269					mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		CAGAAACTGAGGGGACATAAT	0.363			NA											8	45	---	---	---	---	NA	NA	NA	NA	NA
CDK14	5218	broad.mit.edu	37	7	90419930	90419930	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:90419930delG	uc003uky.2	+	5	729	c.507delG	c.(505-507)CAGfs	p.Q169fs	CDK14_uc003ukt.1_Frame_Shift_Del_p.Q123fs|CDK14_uc003ukv.1_Frame_Shift_Del_p.Q123fs|CDK14_uc003uku.1_Frame_Shift_Del_p.Q123fs|CDK14_uc003ukx.1_RNA|CDK14_uc003ukz.1_Frame_Shift_Del_p.Q151fs|CDK14_uc010les.1_Frame_Shift_Del_p.Q123fs|CDK14_uc011khl.1_Frame_Shift_Del_p.Q40fs	NM_012395	NP_036527	O94921	CDK14_HUMAN	PFTAIRE protein kinase 1	169	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4						TCAGGCTGCAGGAAGAAGAAG	0.393	GBM(83;1228 1256 8311 16577 31299)		NA											132	65	---	---	---	---	NA	NA	NA	NA	NA
MUC17	140453	broad.mit.edu	37	7	100678729	100678729	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:100678729delC	uc003uxp.1	+	3	4085	c.4032delC	c.(4030-4032)GTCfs	p.V1344fs	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1344	Extracellular (Potential).|20.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GTATACCTGTCAACACCACAC	0.458			NA											155	78	---	---	---	---	NA	NA	NA	NA	NA
GIMAP7	168537	broad.mit.edu	37	7	150217654	150217654	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chr7:150217654delG	uc003whk.2	+	2	722	c.592delG	c.(592-594)GGGfs	p.G198fs		NM_153236	NP_694968	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	198							GTP binding			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GTGCAACGAAGGGGCTTACTT	0.438			NA											29	16	---	---	---	---	NA	NA	NA	NA	NA
CXorf59	286464	broad.mit.edu	37	X	36117970	36117993	+	In_Frame_Del	DEL	ACAGATGTATTTCTACAGATATAC	ACAGATGTATTTCTACAGATATAC	-	rs113466978		TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	ACAGATGTATTTCTACAGATATAC	ACAGATGTATTTCTACAGATATAC	-	-	ACAGATGTATTTCTACAGATATAC	ACAGATGTATTTCTACAGATATAC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:36117970_36117993delACAGATGTATTTCTACAGATATAC	uc004ddk.1	+	7	1012_1035	c.826_849delACAGATGTATTTCTACAGATATAC	c.(826-849)ACAGATGTATTTCTACAGATATACdel	p.TDVFLQIY276del		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	276_283						integral to membrane				central_nervous_system(1)	1						ACGGGCATGGACAGATGTATTTCTACAGATATACAAGGTAACAT	0.33			NA											7	69	---	---	---	---	NA	NA	NA	NA	NA
MAGED1	9500	broad.mit.edu	37	X	51644748	51644749	+	Frame_Shift_Ins	INS	-	-	G	rs3199687	byFrequency	TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:51644748_51644749insG	uc004dpm.2	+	12	2154_2155	c.2059_2060insG	c.(2059-2061)CGGfs	p.R687fs	MAGED1_uc004dpn.2_Frame_Shift_Ins_p.R743fs|MAGED1_uc004dpo.2_Frame_Shift_Ins_p.R687fs	NM_001005332	NP_001005332	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1 isoform b	687					apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			ovary(3)	3	Ovarian(276;0.236)					GGCCGAAGCCCGGGCTGAAGCA	0.574			NA								Multiple Myeloma(10;0.10)			15	23	---	---	---	---	NA	NA	NA	NA	NA
ZXDB	158586	broad.mit.edu	37	X	57619478	57619478	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:57619478delC	uc004dvd.2	+	1	1210	c.997delC	c.(997-999)CCCfs	p.P333fs		NM_007157	NP_009088	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	333	Required for interaction with ZXDC (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						CAAACTGCGGCCCTTTGGCTG	0.597			NA											9	32	---	---	---	---	NA	NA	NA	NA	NA
PJA1	64219	broad.mit.edu	37	X	68381849	68381849	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:68381849delG	uc004dxh.2	-	2	1519	c.1233delC	c.(1231-1233)GCCfs	p.A411fs	PJA1_uc011mpi.1_Frame_Shift_Del_p.A129fs|PJA1_uc004dxg.2_Frame_Shift_Del_p.A223fs|PJA1_uc004dxi.2_Frame_Shift_Del_p.A356fs	NM_145119	NP_660095	Q8NG27	PJA1_HUMAN	praja 1 isoform a	411							zinc ion binding				0						TGCCAGTGCTGGCACTCACCT	0.622			NA											12	35	---	---	---	---	NA	NA	NA	NA	NA
EMD	2010	broad.mit.edu	37	X	153608718	153608718	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7670-01A-11D-2063-08	TCGA-44-7670-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2342c577-a2e8-4239-ba8e-bbf1c62e7741	f5a0150c-19b8-43ad-8e1a-7c2608c388ae	g.chrX:153608718delC	uc004fkl.2	+	4	638	c.390delC	c.(388-390)TTCfs	p.F130fs		NM_000117	NP_000108	P50402	EMD_HUMAN	emerin	130	Interaction with F-actin (Probable).				cellular response to growth factor stimulus|muscle contraction|muscle organ development|negative regulation of catenin import into nucleus|negative regulation of fibroblast proliferation|positive regulation of protein export from nucleus|regulation of canonical Wnt receptor signaling pathway	endoplasmic reticulum|integral to membrane|microtubule|nuclear inner membrane|nuclear outer membrane	actin binding|beta-tubulin binding				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGACGCTTTCCATCACCAGG	0.587			NA											21	38	---	---	---	---	NA	NA	NA	NA	NA
