Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
C1orf64	149563	broad.mit.edu	37	1	16332490	16332490	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:16332490G>T	uc001axn.2	+	2	227	c.159G>T	c.(157-159)AAG>AAT	p.K53N		NM_178840	NP_849162	Q8NEQ6	CA064_HUMAN	hypothetical protein LOC149563	53										breast(2)	2		Colorectal(325;0.000435)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;2.08e-05)|BRCA - Breast invasive adenocarcinoma(304;9.19e-05)|Kidney(64;0.000165)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0114)|READ - Rectum adenocarcinoma(331;0.0649)		CCCACGGGAAGCAGCTCTCCC	0.572			NA											22	199					5.26018e-13	9.04591e-13	0.001882	1	0
HSPG2	3339	broad.mit.edu	37	1	22174314	22174314	+	Silent	SNP	C	C	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:22174314C>T	uc001bfj.2	-	61	7933	c.7893G>A	c.(7891-7893)CCG>CCA	p.P2631P	HSPG2_uc009vqd.2_Silent_p.P2632P	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2631	Ig-like C2-type 12.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CGATCCTGATCGGTGGGGAGA	0.627			NA											6	41					0	0	0.00308	0	0
TMEM200B	399474	broad.mit.edu	37	1	29447669	29447669	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:29447669G>T	uc001brn.1	-	2	732	c.672C>A	c.(670-672)TAC>TAA	p.Y224*		NM_001003682	NP_001003682	Q69YZ2	T200B_HUMAN	transmembrane protein 200B	224	Pro-rich.					integral to membrane					0		Colorectal(325;3.46e-05)|Breast(348;0.00765)|Lung NSC(340;0.0153)|all_lung(284;0.0173)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;7.32e-08)|COAD - Colon adenocarcinoma(152;4.92e-06)|STAD - Stomach adenocarcinoma(196;0.00618)|BRCA - Breast invasive adenocarcinoma(304;0.0501)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.126)		CCTTCAGCGGGTAGCTGTTGA	0.647			NA											3	24					0.004672	0.00522435	0.004672	1	0
C8A	731	broad.mit.edu	37	1	57349256	57349256	+	Missense_Mutation	SNP	G	G	T	rs141666945		TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:57349256G>T	uc001cyo.2	+	6	889	c.757G>T	c.(757-759)GGC>TGC	p.G253C		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	253	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						AGTGACCATCGGCATAGGCCC	0.428			NA											7	69					8.12818e-05	0.000101379	0.001984	1	0
SELENBP1	8991	broad.mit.edu	37	1	151338767	151338767	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:151338767C>A	uc001exx.2	-	7	874	c.827G>T	c.(826-828)CGC>CTC	p.R276L	SELENBP1_uc010pcy.1_Missense_Mutation_p.R318L|SELENBP1_uc001exy.2_Missense_Mutation_p.R173L|SELENBP1_uc001exz.2_Missense_Mutation_p.R173L|SELENBP1_uc010pcz.1_Missense_Mutation_p.R214L|SELENBP1_uc009wms.2_Missense_Mutation_p.R112L|SELENBP1_uc009wmt.2_Missense_Mutation_p.R173L|SELENBP1_uc001eya.2_Missense_Mutation_p.R212L|SELENBP1_uc009wmu.2_Missense_Mutation_p.R173L	NM_003944	NP_003935	Q13228	SBP1_HUMAN	selenium binding protein 1	276					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding				0	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CTTGTAGAAGCGCTGGATGGT	0.572			NA											34	132					3.11337e-16	5.56485e-16	0.002836	1	0
SCAMP3	10067	broad.mit.edu	37	1	155227303	155227303	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:155227303C>G	uc001fjs.2	-	6	916	c.663G>C	c.(661-663)ATG>ATC	p.M221I	RAG1AP1_uc010pey.1_Intron|FAM189B_uc001fjm.2_5'Flank|FAM189B_uc001fjn.2_5'Flank|FAM189B_uc001fjo.2_5'Flank|FAM189B_uc001fjp.2_5'Flank|FAM189B_uc001fjq.1_5'Flank|SCAMP3_uc001fjr.2_Missense_Mutation_p.M68I|SCAMP3_uc001fju.2_Missense_Mutation_p.M207I|SCAMP3_uc001fjv.2_Missense_Mutation_p.M221I|SCAMP3_uc001fjt.2_Missense_Mutation_p.M195I	NM_005698	NP_005689	O14828	SCAM3_HUMAN	secretory carrier membrane protein 3 isoform 1	221					post-Golgi vesicle-mediated transport|protein transport	integral to membrane				ovary(3)	3	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			AAGCCTTATACATGGGGCGGT	0.547			NA											3	27					0	0	0.004672	0	0
ASH1L	55870	broad.mit.edu	37	1	155408566	155408566	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:155408566G>A	uc009wqq.2	-	5	5860	c.5380C>T	c.(5380-5382)CAT>TAT	p.H1794Y	ASH1L_uc001fkt.2_Missense_Mutation_p.H1794Y	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	1794					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CTCTTGATATGATGGGGGGAA	0.433			NA											10	155					0	0	0.006214	0	0
PYHIN1	149628	broad.mit.edu	37	1	158911793	158911793	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:158911793C>A	uc001ftb.2	+	5	851	c.606C>A	c.(604-606)CAC>CAA	p.H202Q	PYHIN1_uc001ftc.2_Missense_Mutation_p.H193Q|PYHIN1_uc001ftd.2_Missense_Mutation_p.H202Q|PYHIN1_uc001fte.2_Missense_Mutation_p.H193Q	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	202	HIN-200.				cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					CCAACCGTCACGCAACTGCCA	0.373			NA											9	54					3.86212e-05	4.92529e-05	0.008291	1	0
CD244	51744	broad.mit.edu	37	1	160801171	160801171	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:160801171C>A	uc009wtq.2	-	9	1257	c.1079G>T	c.(1078-1080)CGC>CTC	p.R360L	CD244_uc001fxa.2_Missense_Mutation_p.R355L|CD244_uc009wtp.2_RNA|CD244_uc009wtr.2_Missense_Mutation_p.R263L	NM_016382	NP_057466	Q9BZW8	CD244_HUMAN	CD244 natural killer cell receptor 2B4	360	Cytoplasmic (Potential).				blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CAGCTCTTTGCGGCTCAATCG	0.433			NA											9	124					1.08611e-07	1.58043e-07	0.000978	1	0
OLFML2B	25903	broad.mit.edu	37	1	161953806	161953806	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:161953806C>A	uc001gbu.2	-	8	2336	c.1912G>T	c.(1912-1914)GAT>TAT	p.D638Y	OLFML2B_uc001gbt.2_Missense_Mutation_p.D121Y|OLFML2B_uc010pkq.1_Missense_Mutation_p.D639Y	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	638	Olfactomedin-like.									skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			AAGCCCTCATCGTCCAGGGCC	0.632			NA											6	62					0.00116845	0.00133958	0.001168	1	0
TNN	63923	broad.mit.edu	37	1	175086110	175086110	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:175086110G>A	uc001gkl.1	+	10	2268	c.2155G>A	c.(2155-2157)GTG>ATG	p.V719M		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	719	Fibronectin type-III 6.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GACCGACCGGGTGACAGAGAA	0.527			NA											21	121					0	0	0.002299	0	0
FAM5C	339479	broad.mit.edu	37	1	190067232	190067232	+	Silent	SNP	C	C	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:190067232C>G	uc001gse.1	-	8	2449	c.2217G>C	c.(2215-2217)GTG>GTC	p.V739V	FAM5C_uc010pot.1_Silent_p.V637V	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	739						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GGATCCTCACCACCTCACTAG	0.438			NA											12	105					0	0	0.000978	0	0
KCNT2	343450	broad.mit.edu	37	1	196309558	196309558	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:196309558G>T	uc001gtd.1	-	16	1756	c.1696C>A	c.(1696-1698)CAA>AAA	p.Q566K	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.Q516K|KCNT2_uc001gtf.1_Missense_Mutation_p.Q566K|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.Q566K|KCNT2_uc001gth.1_Missense_Mutation_p.Q87K	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	566	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TGCTGGTCTTGGTTTTTAAAT	0.353			NA											11	72					1.08611e-07	1.58043e-07	0.000978	1	0
LAMB3	3914	broad.mit.edu	37	1	209799302	209799302	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:209799302C>G	uc001hhg.2	-	13	2057	c.1667G>C	c.(1666-1668)CGC>CCC	p.R556P	LAMB3_uc009xco.2_Missense_Mutation_p.R556P|LAMB3_uc001hhh.2_Missense_Mutation_p.R556P|LAMB3_uc010psl.1_Intron|hsa-mir-4260|MI0015859_5'Flank	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	556	Laminin EGF-like 6.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		CAAGCCAGGGCGGCAGAGGCA	0.622			NA											6	21					0	0	0.00308	0	0
OBSCN	84033	broad.mit.edu	37	1	228558725	228558725	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:228558725G>A	uc009xez.1	+	94	20290	c.20246G>A	c.(20245-20247)CGT>CAT	p.R6749H	OBSCN_uc001hsr.1_Missense_Mutation_p.R1378H	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6749					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CGGTTCCAGCGTTCCCTGATG	0.677			NA											8	59					0	0	0.004482	0	0
C1orf124	83932	broad.mit.edu	37	1	231474216	231474216	+	Silent	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:231474216G>T	uc001hur.2	+	1	535	c.87G>T	c.(85-87)CTG>CTT	p.L29L	EXOC8_uc001huq.2_5'Flank|C1orf124_uc001hus.2_Silent_p.L29L|C1orf124_uc001hut.2_Silent_p.L29L	NM_032018	NP_114407	Q9H040	CA124_HUMAN	hypothetical protein LOC83932 isoform a	29					DNA repair	nuclear speck	DNA binding|metal ion binding				0	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				AGGAGTCCCTGTCGCTAGTGG	0.582	Esophageal Squamous(43;65 937 18756 45127 47168)		NA											16	91					2.62699e-14	4.58712e-14	0.003163	1	0
ACTN2	88	broad.mit.edu	37	1	236898975	236898975	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:236898975G>T	uc001hyf.2	+	8	942	c.738G>T	c.(736-738)ATG>ATT	p.M246I	ACTN2_uc001hyg.2_Missense_Mutation_p.M1I|ACTN2_uc009xgi.1_Intron|ACTN2_uc010pxu.1_Intron	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	246	CH 2.|Actin-binding.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GAGCCATCATGACGTACGTCT	0.522			NA											5	64					3.59834e-05	4.64104e-05	0.001168	1	0
RGS7	6000	broad.mit.edu	37	1	240969527	240969527	+	Silent	SNP	G	G	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:240969527G>C	uc001hyv.2	-	15	1512	c.1182C>G	c.(1180-1182)CCC>CCG	p.P394P	RGS7_uc010pyh.1_Silent_p.P368P|RGS7_uc010pyj.1_Silent_p.P310P|RGS7_uc001hyu.2_Silent_p.P394P|RGS7_uc009xgn.1_Silent_p.P341P|RGS7_uc001hyw.2_Silent_p.P394P|RGS7_uc001hyt.2_Silent_p.P226P	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	394	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TAATAGCACTGGGGGCTCCGG	0.478			NA											15	104					0	0	0.003163	0	0
OR2T12	127064	broad.mit.edu	37	1	248458056	248458056	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:248458056G>C	uc010pzj.1	-	1	825	c.825C>G	c.(823-825)TTC>TTG	p.F275L		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	275	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ACATAGTATAGAAGGCTGACA	0.483			NA											23	152					0	0	0.00333	0	0
OR2T11	127077	broad.mit.edu	37	1	248790268	248790268	+	Silent	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:248790268G>T	uc001ier.1	-	1	162	c.162C>A	c.(160-162)ACC>ACA	p.T54T		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGTACATGGGGGTGTGGAGGC	0.478			NA											18	27					2.5808e-16	4.64953e-16	0.006122	1	0
CDC123	8872	broad.mit.edu	37	10	12292308	12292308	+	Splice_Site	SNP	A	A	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr10:12292308A>G	uc001ill.2	+	13	1269	c.985_splice	c.e13-2	p.K329_splice	CDC123_uc001ilm.2_Splice_Site_p.K341_splice	NM_006023	NP_006014	O75794	CD123_HUMAN	cell division cycle 123						cell cycle arrest|cell division|positive regulation of cell proliferation|regulation of mitotic cell cycle	cytoplasm				central_nervous_system(1)	1						TTTCTTTGACAGAAGAGAAAT	0.502			NA											10	39					0	0	0.001368	0	0
SLC39A12	221074	broad.mit.edu	37	10	18292257	18292257	+	Silent	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr10:18292257G>T	uc001ipo.2	+	12	2190	c.1917G>T	c.(1915-1917)GGG>GGT	p.G639G	SLC39A12_uc001ipn.2_Silent_p.G602G|SLC39A12_uc001ipp.2_Silent_p.G638G|SLC39A12_uc010qck.1_Silent_p.G505G|uc001ipq.1_RNA	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	639	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						TCACTGCTGGGATGTTCTTAT	0.373			NA											20	103					9.7654e-05	0.000121134	0.007413	1	0
ADK	132	broad.mit.edu	37	10	76158301	76158301	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr10:76158301G>A	uc001jwi.2	+	6	591	c.519G>A	c.(517-519)TGG>TGA	p.W173*	ADK_uc010qlb.1_Nonsense_Mutation_p.W173*|ADK_uc001jwj.2_Nonsense_Mutation_p.W156*|ADK_uc010qlc.1_Nonsense_Mutation_p.W138*	NM_006721	NP_006712	P55263	ADK_HUMAN	adenosine kinase isoform b	173					purine base metabolic process|purine ribonucleoside salvage	cytosol	adenosine kinase activity|ATP binding|metal ion binding|phosphotransferase activity, alcohol group as acceptor			ovary(1)|skin(1)	2	Prostate(51;0.0112)|Ovarian(15;0.148)				Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Pegademase bovine(DB00061)|Ribavirin(DB00811)	AGAAAAACTGGATGTTGGTAG	0.328			NA											3	30					0	0	0.009096	0	0
VENTX	27287	broad.mit.edu	37	10	135053795	135053795	+	Silent	SNP	G	G	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr10:135053795G>A	uc010quy.1	+	3	773	c.762G>A	c.(760-762)ACG>ACA	p.T254T		NM_014468	NP_055283	O95231	VENTX_HUMAN	VENT homeobox	254					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(35;4.15e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.8e-06)|Epithelial(32;9.31e-06)|all cancers(32;1.19e-05)		TGCCACAGACGGGGGATGCAT	0.657			NA											3	30					0	0	0.004672	0	0
LOC338651	338651	broad.mit.edu	37	11	1619623	1619623	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr11:1619623C>G	uc009ycx.1	+	2	1474	c.723C>G	c.(721-723)CAC>CAG	p.H241Q	LOC338651_uc001ltt.1_RNA|KRTAP5-2_uc001ltv.2_5'Flank	NR_021489				SubName: Full=cDNA FLJ30579 fis, clone BRAWH2006989, weakly similar to DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT;          EC=2.7.7.6;												0						ACTGTTTACACTATTTTTCCA	0.448			NA											5	38					0	0	0.000602	0	0
OR52J3	119679	broad.mit.edu	37	11	5068356	5068356	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr11:5068356G>A	uc010qyv.1	+	1	601	c.601G>A	c.(601-603)GGG>AGG	p.G201R		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	201	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGTATCTATGGGCTTTTTGT	0.448			NA											18	102					0	0	0.007413	0	0
SYT9	143425	broad.mit.edu	37	11	7441739	7441739	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr11:7441739T>A	uc001mfe.2	+	6	1577	c.1340T>A	c.(1339-1341)GTA>GAA	p.V447E	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_RNA	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	447	Cytoplasmic (Potential).|C2 2.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		TTTCACAGTGTAGGTCACAAT	0.428			NA											12	79					0	0	0.001855	0	0
NLRP10	338322	broad.mit.edu	37	11	7981383	7981383	+	Silent	SNP	A	A	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr11:7981383A>G	uc001mfv.1	-	2	1793	c.1776T>C	c.(1774-1776)AAT>AAC	p.N592N		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	592							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ATTTCTTTTCATTTGAATGTT	0.373			NA											6	41					0	0	0.001984	0	0
ANO3	63982	broad.mit.edu	37	11	26677945	26677945	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr11:26677945C>A	uc001mqt.3	+	26	2825	c.2680C>A	c.(2680-2682)CCC>ACC	p.P894T	ANO3_uc010rdr.1_Missense_Mutation_p.P878T|ANO3_uc010rds.1_Missense_Mutation_p.P733T|ANO3_uc010rdt.1_Missense_Mutation_p.P748T	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	894	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CAGAGGCCCGCCCTGGAGTTC	0.413			NA											17	91					8.28177e-16	1.46872e-15	0.007413	1	0
LOC440040	440040	broad.mit.edu	37	11	49597897	49597897	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr11:49597897G>T	uc010rhy.1	+	2	488	c.10G>T	c.(10-12)GAC>TAC	p.D4Y	LOC440040_uc009ymb.2_Missense_Mutation_p.D4Y	NR_027044				SubName: Full=cDNA FLJ60249, highly similar to Metabotropic glutamate receptor 5;												0						CATGCTGGGTGACATCATTAT	0.498			NA											10	37					0.000673444	0.000783958	0.008291	1	0
OR5T3	390154	broad.mit.edu	37	11	56020007	56020007	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr11:56020007T>C	uc010rjd.1	+	1	332	c.332T>C	c.(331-333)ATG>ACG	p.M111T		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	111	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					ACTCCAAAAATGTTGGTCAAT	0.358			NA											22	135					0	0	0.002299	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947368	57947368	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr11:57947368C>A	uc001nmj.2	+	3	768	c.452C>A	c.(451-453)GCT>GAT	p.A151D		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	151	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				GCTTACGTTGCTGGTCTCATC	0.547			NA											8	55					5.4927e-09	8.59892e-09	0.004482	1	0
LRRC32	2615	broad.mit.edu	37	11	76372160	76372160	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr11:76372160G>T	uc001oxq.3	-	3	720	c.477C>A	c.(475-477)AAC>AAA	p.N159K	LRRC32_uc001oxr.3_Missense_Mutation_p.N159K|LRRC32_uc010rsf.1_Missense_Mutation_p.N159K	NM_005512	NP_005503	Q14392	LRC32_HUMAN	leucine rich repeat containing 32 precursor	159	Extracellular (Potential).|LRR 5.					integral to plasma membrane					0						GAGTCAGACTGTTCTCCGCCA	0.642			NA											8	40					3.09899e-07	4.45234e-07	0.004482	1	0
CCDC89	220388	broad.mit.edu	37	11	85396655	85396655	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr11:85396655C>A	uc001pau.1	-	1	666	c.519G>T	c.(517-519)GAG>GAT	p.E173D		NM_152723	NP_689936	Q8N998	CCD89_HUMAN	coiled-coil domain containing 89	173	Potential.					cytoplasm|nucleus					0		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				ATACTTTCGCCTCCTCATCCT	0.552			NA											21	105					8.10497e-08	1.21041e-07	0.010504	1	0
FAT3	120114	broad.mit.edu	37	11	92087327	92087327	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr11:92087327C>A	uc001pdj.3	+	1	2066	c.2049C>A	c.(2047-2049)TGC>TGA	p.C683*		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	683	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCTTCAGTTGCAGAGAAACTC	0.413			NA								TCGA Ovarian(4;0.039)			12	62					7.93312e-07	1.1048e-06	0.00245	1	0
CDON	50937	broad.mit.edu	37	11	125887047	125887047	+	Silent	SNP	A	A	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr11:125887047A>G	uc009zbw.2	-	6	992	c.864T>C	c.(862-864)TAT>TAC	p.Y288Y	CDON_uc001qdc.3_Silent_p.Y288Y|CDON_uc001qdd.3_RNA|CDON_uc009zbx.2_Silent_p.Y288Y	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	288	Extracellular (Potential).|Ig-like C2-type 3.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		CCATGCAGGAATAGTTTCCGG	0.438			NA											4	33					0	0	0.000602	0	0
PRMT8	56341	broad.mit.edu	37	12	3662861	3662861	+	Silent	SNP	G	G	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr12:3662861G>A	uc001qmf.2	+	4	829	c.462G>A	c.(460-462)AAG>AAA	p.K154K	PRMT8_uc009zed.2_Silent_p.K145K|PRMT8_uc009zee.1_RNA	NM_019854	NP_062828	Q9NR22	ANM8_HUMAN	HMT1 hnRNP methyltransferase-like 4	154					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			ovary(3)|central_nervous_system(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			AGATCATTAAGGCCAACCACT	0.478			NA											16	81					0	0	0.004007	0	0
PDE3A	5139	broad.mit.edu	37	12	20833070	20833070	+	Silent	SNP	A	A	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr12:20833070A>T	uc001reh.1	+	16	3313	c.3291A>T	c.(3289-3291)GCA>GCT	p.A1097A		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	1097					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	AACGGTTGGCAGGCATAGAAA	0.448			NA											6	86					0	0	0.001168	0	0
SOX5	6660	broad.mit.edu	37	12	23728634	23728634	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr12:23728634C>A	uc001rfw.2	-	10	1405	c.1303G>T	c.(1303-1305)GCA>TCA	p.A435S	SOX5_uc001rfx.2_Missense_Mutation_p.A422S|SOX5_uc001rfy.2_Intron|SOX5_uc001rfv.2_Missense_Mutation_p.A49S|SOX5_uc010siv.1_Missense_Mutation_p.A422S|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.A387S	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	435					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						GCTAACGCTGCTGGGACAGAG	0.478			NA											14	232					2.32078e-09	3.70999e-09	0.003163	1	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	G	rs121913529		TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr12:25398284C>G	uc001rgp.1	-	2	216	c.35G>C	c.(34-36)GGT>GCT	p.G12A	KRAS_uc001rgq.1_Missense_Mutation_p.G12A|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			24	23					0	0	0.005443	0	0
OR8S1	341568	broad.mit.edu	37	12	48919740	48919741	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr12:48919740_48919741GG>TT	uc010slu.1	+	1	326_327	c.326_327GG>TT	c.(325-327)GGG>GTT	p.G109V		NM_001005203	NP_001005203	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GTCACTGCAGGGACTGAAGCCT	0.525			NA											12	72					0	0	0.004672	0	0
DGKA	1606	broad.mit.edu	37	12	56334126	56334126	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr12:56334126G>T	uc001sij.2	+	11	1091	c.827G>T	c.(826-828)GGC>GTC	p.G276V	DGKA_uc009zoc.1_Missense_Mutation_p.G276V|DGKA_uc001sih.1_Missense_Mutation_p.G164V|DGKA_uc001sii.1_Missense_Mutation_p.G134V|DGKA_uc009zod.1_Missense_Mutation_p.G195V|DGKA_uc009zoe.1_3'UTR|DGKA_uc001sik.2_Missense_Mutation_p.G276V|DGKA_uc001sil.2_Missense_Mutation_p.G276V|DGKA_uc001sim.2_Missense_Mutation_p.G276V|DGKA_uc001sin.2_Missense_Mutation_p.G276V|DGKA_uc009zof.2_5'UTR|DGKA_uc001sio.2_Missense_Mutation_p.G18V	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	276	Phorbol-ester/DAG-type 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	GTGCGAGGAGGCTGTGAGTCC	0.597			NA									OREG0021913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	111					0.000157383	0.000191048	0.00308	1	0
GLIPR1L2	144321	broad.mit.edu	37	12	75804431	75804431	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr12:75804431G>T	uc001sxr.1	+	2	460	c.452G>T	c.(451-453)TGC>TTC	p.C151F	GLIPR1L2_uc001sxp.1_Missense_Mutation_p.C151F|GLIPR1L2_uc001sxq.1_Missense_Mutation_p.C44F	NM_152436	NP_689649	Q4G1C9	GRPL2_HUMAN	GLI pathogenesis-related 1 like 2	151						integral to membrane				ovary(1)	1						AATGGCAGTTGCTCTGGAGAC	0.313			NA											7	40					2.0095e-06	2.73147e-06	0.001984	1	0
ALX1	8092	broad.mit.edu	37	12	85677595	85677595	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr12:85677595G>T	uc001tae.3	+	2	476	c.472G>T	c.(472-474)GAT>TAT	p.D158Y		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	158	Homeobox.				brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		TCATTACCCGGATGTGTATGT	0.498			NA											13	103					4.14922e-12	6.97683e-12	0.004007	1	0
SLC5A8	160728	broad.mit.edu	37	12	101573839	101573839	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr12:101573839C>A	uc001thz.3	-	10	1591	c.1201G>T	c.(1201-1203)GCG>TCG	p.A401S		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	401	Helical; (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						GACGCCAGCGCAGCCATTCCA	0.428	GBM(60;420 1056 13605 22380 47675)		NA											10	118					0.000151284	0.000186639	0.001855	1	0
RBM19	9904	broad.mit.edu	37	12	114362517	114362517	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr12:114362517T>A	uc009zwi.2	-	18	2434	c.2290A>T	c.(2290-2292)AAG>TAG	p.K764*	RBM19_uc001tvn.3_Nonsense_Mutation_p.K764*|RBM19_uc001tvm.2_Nonsense_Mutation_p.K764*	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	764	RRM 5.				multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					TTGTTCTTCTTCTTGGAGATG	0.448			NA											17	105					0	0	0.006122	0	0
PIWIL1	9271	broad.mit.edu	37	12	130840124	130840124	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr12:130840124G>A	uc001uik.2	+	12	1406	c.1316G>A	c.(1315-1317)CGA>CAA	p.R439Q	PIWIL1_uc001uij.1_Missense_Mutation_p.R439Q	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	439					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		AGGGAGCTTCGAGACTGGGGT	0.393			NA											7	196					0	0	0.004482	0	0
ULK1	8408	broad.mit.edu	37	12	132393327	132393327	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr12:132393327G>T	uc001uje.2	+	6	723	c.455G>T	c.(454-456)CGC>CTC	p.R152L		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	152	Protein kinase.				autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		CCCGCCGGCCGCCGCGCCAAC	0.473			NA											5	26					0.00116845	0.00133958	0.001168	1	0
SACS	26278	broad.mit.edu	37	13	23909100	23909100	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr13:23909100G>T	uc001uon.2	-	10	9504	c.8915C>A	c.(8914-8916)CCA>CAA	p.P2972Q	SACS_uc001uoo.2_Missense_Mutation_p.P2825Q|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	2972					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		ATATAAATCTGGCTGTAGATC	0.383			NA											7	92					2.7689e-08	4.21839e-08	0.001984	1	0
CCDC70	83446	broad.mit.edu	37	13	52439850	52439850	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr13:52439850G>T	uc001vfu.3	+	2	632	c.336G>T	c.(334-336)AAG>AAT	p.K112N	uc010tgr.1_RNA	NM_031290	NP_112580	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70 precursor	112						extracellular region|plasma membrane					0		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		AAATGGAAAAGTCTTTCAGGG	0.468			NA											15	107					1.5739e-10	2.57032e-10	0.004007	1	0
NALCN	259232	broad.mit.edu	37	13	101735531	101735531	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr13:101735531G>T	uc001vox.1	-	32	3791	c.3602C>A	c.(3601-3603)GCT>GAT	p.A1201D		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1201	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ATACATTTTAGCTCTAAAACC	0.388			NA											5	32					0.000602214	0.000704653	0.000602	1	0
MYO16	23026	broad.mit.edu	37	13	109365023	109365023	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr13:109365023A>C	uc001vqt.1	+	3	367	c.241A>C	c.(241-243)AAG>CAG	p.K81Q	MYO16_uc010agk.1_Missense_Mutation_p.K103Q	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	81	ANK 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TCGGCTCCTGAAGGAGGGGGC	0.557			NA											8	82					0	0	0.004482	0	0
COL4A2	1284	broad.mit.edu	37	13	111147722	111147722	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr13:111147722G>A	uc001vqx.2	+	40	3957	c.3668G>A	c.(3667-3669)GGC>GAC	p.G1223D		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	1223	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGCTTCCCAGGCCCTCCTGGG	0.567			NA											10	96					0	0	0.000978	0	0
AK7	122481	broad.mit.edu	37	14	96916184	96916184	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr14:96916184A>T	uc001yfn.2	+	9	960	c.916A>T	c.(916-918)AGA>TGA	p.R306*		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	306	Potential.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		GAAAATACCCAGAGAAAATGC	0.313			NA											4	33					0	0	0.000602	0	0
OR4N4	283694	broad.mit.edu	37	15	22382661	22382661	+	Silent	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr15:22382661G>T	uc001yuc.1	+	7	1170	c.189G>T	c.(187-189)CTG>CTT	p.L63L	LOC727924_uc001yub.1_RNA|OR4N4_uc010tzv.1_Silent_p.L63L	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		ATTTATTTCTGGGCAACTTGG	0.458			NA											30	270					1.41504e-22	2.63289e-22	0.002852	1	0
MYO9A	4649	broad.mit.edu	37	15	72190149	72190149	+	Silent	SNP	G	G	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr15:72190149G>C	uc002atl.3	-	25	5168	c.4695C>G	c.(4693-4695)ACC>ACG	p.T1565T	MYO9A_uc010biq.2_Silent_p.T1185T|MYO9A_uc002atn.1_Silent_p.T1546T|MYO9A_uc002atk.2_Silent_p.T289T|MYO9A_uc002atm.1_Silent_p.T289T	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1565	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						CCTTATTTGAGGTATTTAAGC	0.448			NA											10	31					0	0	0.008291	0	0
WASH3P	374666	broad.mit.edu	37	15	102516350	102516350	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr15:102516350G>A	uc002cdi.2	+	11	2096	c.676G>A	c.(676-678)GGA>AGA	p.G226R	WASH3P_uc002cdl.2_Missense_Mutation_p.G226R|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.G226R|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						CTCTGGGAAAGGACCTGGGGC	0.622			NA											4	10					0	0	0.000602	0	0
PLK1	5347	broad.mit.edu	37	16	23691457	23691457	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr16:23691457G>T	uc002dlz.1	+	2	514	c.461G>T	c.(460-462)CGA>CTA	p.R154L		NM_005030	NP_005021	P53350	PLK1_HUMAN	polo-like kinase 1	154	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			lung(1)|skin(1)	2				GBM - Glioblastoma multiforme(48;0.0156)		CCTGAGGCCCGATACTACCTA	0.557	Colon(12;240 564 27038 33155)		NA											7	43					8.12818e-05	0.000101379	0.001984	1	0
IRX3	79191	broad.mit.edu	37	16	54318982	54318982	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr16:54318982C>A	uc002eht.1	-	2	1227	c.811G>T	c.(811-813)GCT>TCT	p.A271S		NM_024336	NP_077312	P78415	IRX3_HUMAN	iroquois homeobox 3	271					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCGCCCCAGCCAGGGACAGC	0.473	GBM(143;1830 1866 4487 4646 37383)		NA											10	21					3.07112e-06	4.05316e-06	0.000978	1	0
NQO1	1728	broad.mit.edu	37	16	69744882	69744882	+	Silent	SNP	T	T	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr16:69744882T>C	uc002exp.2	-	6	1013	c.822A>G	c.(820-822)AAA>AAG	p.K274K	NQO1_uc010cfm.2_Silent_p.K253K|NQO1_uc002exq.2_Silent_p.K240K|NQO1_uc002exr.2_Silent_p.K236K|NQO1_uc010vll.1_Silent_p.K202K	NM_000903	NP_000894	P15559	NQO1_HUMAN	NAD(P)H menadione oxidoreductase 1,	274					nitric oxide biosynthetic process|regulation of cellular amino acid metabolic process|response to toxin|synaptic transmission, cholinergic|xenobiotic metabolic process	cytosol	coenzyme binding|cytochrome-b5 reductase activity|electron carrier activity|NAD(P)H dehydrogenase (quinone) activity				0					Dicumarol(DB00266)|Menadione(DB00170)	AGGAATCTCATTTTCTAGCTT	0.408			NA											25	67					0	0	0.008361	0	0
GUCY2D	3000	broad.mit.edu	37	17	7915566	7915566	+	Silent	SNP	C	C	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr17:7915566C>T	uc002gjt.2	+	9	1928	c.1854C>T	c.(1852-1854)GTC>GTT	p.V618V		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	618	Protein kinase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				TGGCTGTGGTCTCAGAGCACT	0.612			NA											12	37					0	0	0.001855	0	0
EFCAB5	374786	broad.mit.edu	37	17	28405333	28405333	+	Silent	SNP	C	C	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr17:28405333C>T	uc002het.2	+	15	3030	c.2838C>T	c.(2836-2838)CTC>CTT	p.L946L	EFCAB5_uc010cse.2_Silent_p.L701L|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	946							calcium ion binding			ovary(1)|skin(1)	2						TGTCTGAACTCAGGGGCAATG	0.428			NA											8	122					0	0	0.004482	0	0
MPP2	4355	broad.mit.edu	37	17	41955346	41955346	+	Silent	SNP	C	C	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr17:41955346C>T	uc010wip.1	-	13	1680	c.1623G>A	c.(1621-1623)GCG>GCA	p.A541A	MPP2_uc002ien.1_Silent_p.A513A|MPP2_uc010wim.1_Silent_p.A485A|MPP2_uc002ieo.1_Silent_p.A496A|MPP2_uc010win.1_Silent_p.A357A|MPP2_uc010wio.1_Silent_p.A485A	NM_005374	NP_005365	Q14168	MPP2_HUMAN	palmitoylated membrane protein 2	520	Guanylate kinase-like.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity				0		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		GTCTCAGGTCCGCCTCCTGCC	0.632			NA											5	49					0	0	0.000602	0	0
GPATCH8	23131	broad.mit.edu	37	17	42476845	42476845	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr17:42476845C>A	uc002igw.1	-	8	2664	c.2600G>T	c.(2599-2601)CGG>CTG	p.R867L	GPATCH8_uc002igv.1_Missense_Mutation_p.R789L|GPATCH8_uc010wiz.1_Missense_Mutation_p.R789L	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	867	Ser-rich.					intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GTAAGAACGCCGGGAGGAACG	0.537			NA											8	97					0.000157383	0.000191048	0.00308	1	0
KIF2B	84643	broad.mit.edu	37	17	51900628	51900628	+	Silent	SNP	G	G	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr17:51900628G>A	uc002iua.2	+	1	390	c.234G>A	c.(232-234)CTG>CTA	p.L78L		NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	78					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CCATACTCCTGCTGAATCCAG	0.567			NA											13	134					0	0	0.00245	0	0
SCPEP1	59342	broad.mit.edu	37	17	55072972	55072972	+	Silent	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr17:55072972G>T	uc002iuv.3	+	8	815	c.762G>T	c.(760-762)GGG>GGT	p.G254G	SCPEP1_uc010dcl.2_RNA|SCPEP1_uc010wnk.1_Silent_p.G204G	NM_021626	NP_067639	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1 precursor	254					proteolysis	extracellular region	serine-type carboxypeptidase activity			skin(1)	1	Breast(9;2.86e-08)					AGCTGTGGGGGAAAGCAGAAA	0.493			NA											12	51					1.08611e-07	1.58043e-07	0.000978	1	0
RGS9	8787	broad.mit.edu	37	17	63221442	63221442	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr17:63221442G>T	uc002jfe.2	+	18	1840	c.1730G>T	c.(1729-1731)CGC>CTC	p.R577L	RGS9_uc010dem.2_Missense_Mutation_p.R574L|RGS9_uc002jfd.2_Missense_Mutation_p.R574L|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Missense_Mutation_p.R348L	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	577					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						CCTAAGGCCCGCATGGCTCTG	0.682			NA											5	115					0.000602214	0.000704653	0.000602	1	0
SEC14L1	6397	broad.mit.edu	37	17	75192327	75192328	+	Missense_Mutation	DNP	GA	GA	TT			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr17:75192327_75192328GA>TT	uc002jto.2	+	8	1020_1021	c.753_754GA>TT	c.(751-756)TTGACT>TTTTCT	p.251_252LT>FS	SEC14L1_uc010dhc.2_Missense_Mutation_p.251_252LT>FS|SEC14L1_uc010wth.1_Missense_Mutation_p.251_252LT>FS|SEC14L1_uc002jtm.2_Missense_Mutation_p.251_252LT>FS|SEC14L1_uc010wti.1_Missense_Mutation_p.217_218LT>FS	NM_003003	NP_002994	Q92503	S14L1_HUMAN	SEC14 (S. cerevisiae)-like 1 isoform a	251_252					transport	Golgi apparatus|integral to membrane	binding			ovary(2)	2						TGGGCGATTTGACTCCGCTGCA	0.51			NA											4	55					0	0	0.004672	0	0
MYOM1	8736	broad.mit.edu	37	18	3134707	3134707	+	Silent	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr18:3134707C>A	uc002klp.2	-	16	2659	c.2325G>T	c.(2323-2325)GCG>GCT	p.A775A	MYOM1_uc002klq.2_Silent_p.A775A	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	775	Fibronectin type-III 3.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						CAGCAACGCTCGCCTCTATGT	0.567			NA											6	45					5.9392e-07	8.3739e-07	0.001168	1	0
EPB41L3	23136	broad.mit.edu	37	18	5434002	5434002	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr18:5434002G>A	uc002kmt.1	-	7	810	c.724C>T	c.(724-726)CCA>TCA	p.P242S	EPB41L3_uc010wzh.1_Missense_Mutation_p.P242S|EPB41L3_uc002kmu.1_Missense_Mutation_p.P242S|EPB41L3_uc010dkq.1_Missense_Mutation_p.P133S|EPB41L3_uc010dks.1_Missense_Mutation_p.P264S|EPB41L3_uc002kmv.1_Missense_Mutation_p.P133S	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	242	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						CATTCATCTGGGTCATAGTCT	0.527			NA											9	168					0	0	0.004482	0	0
RBBP8	5932	broad.mit.edu	37	18	20572760	20572760	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr18:20572760C>T	uc002ktw.2	+	11	1301	c.970C>T	c.(970-972)CGA>TGA	p.R324*	RBBP8_uc002kty.2_Nonsense_Mutation_p.R324*|RBBP8_uc002ktz.2_Nonsense_Mutation_p.R324*|RBBP8_uc002kua.2_Nonsense_Mutation_p.R324*|RBBP8_uc002ktx.1_Nonsense_Mutation_p.R324*	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	324					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			ATTACCTACTCGAGTGTCATC	0.338			NA						Direct_reversal_of_damage|Homologous_recombination					13	85					0	0	0.001855	0	0
LMAN1	3998	broad.mit.edu	37	18	57026271	57026271	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr18:57026271T>A	uc002lhz.2	-	1	238	c.206A>T	c.(205-207)CAC>CTC	p.H69L	LMAN1_uc010xek.1_Missense_Mutation_p.H69L	NM_005570	NP_005561	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1 precursor	69	Lumenal (Potential).|L-type lectin-like.				blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			skin(1)	1		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)	ACTCCCCGCGTGGGCCCAGAA	0.667			NA											6	53					0	0	0.001984	0	0
SEMA6B	10501	broad.mit.edu	37	19	4550282	4550282	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr19:4550282G>T	uc010duc.1	-	11	1162	c.1124C>A	c.(1123-1125)CCC>CAC	p.P375H	SEMA6B_uc010dud.2_Missense_Mutation_p.P375H|SEMA6B_uc010xih.1_Missense_Mutation_p.P375H	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	375	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGCACCCGGGCCTGGGGGT	0.597			NA											6	42					8.12818e-05	0.000101379	0.001984	1	0
TUBB4	10382	broad.mit.edu	37	19	6495936	6495936	+	Silent	SNP	G	G	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr19:6495936G>A	uc002mfg.1	-	4	681	c.574C>T	c.(574-576)CTG>TTG	p.L192L	TUBB4_uc002mff.1_Silent_p.L120L|MIR220B_hsa-mir-220b|MI0005529_5'Flank	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	192					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		TTCTCCACCAGCTGGTGCACA	0.592			NA											33	128					0	0	0.003755	0	0
EMR1	2015	broad.mit.edu	37	19	6928172	6928172	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr19:6928172G>T	uc002mfw.2	+	17	2277	c.2239G>T	c.(2239-2241)GAG>TAG	p.E747*	EMR1_uc010dvc.2_Nonsense_Mutation_p.E682*|EMR1_uc010dvb.2_Nonsense_Mutation_p.E695*|EMR1_uc010xji.1_Nonsense_Mutation_p.E606*|EMR1_uc010xjj.1_Nonsense_Mutation_p.E570*	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	747	Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					GCTGAATACAGAGACAGGGTT	0.498			NA											28	124					3.73988e-18	6.8464e-18	0.00632	1	0
ZNF433	163059	broad.mit.edu	37	19	12127282	12127282	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr19:12127282A>G	uc002msy.1	-	4	571	c.400T>C	c.(400-402)TAT>CAT	p.Y134H	uc002msx.1_Intron|ZNF433_uc002msz.1_Missense_Mutation_p.Y99H	NM_001080411	NP_001073880	Q8N7K0	ZN433_HUMAN	zinc finger protein 433	134					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TATTCTTGATACTCATATGCC	0.393			NA											5	68					0	0	0.000602	0	0
PRKACA	5566	broad.mit.edu	37	19	14208272	14208272	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr19:14208272C>A	uc002myc.2	-	8	866	c.666G>T	c.(664-666)TGG>TGT	p.W222C	PRKACA_uc002myb.2_Missense_Mutation_p.W214C|PRKACA_uc010xnm.1_Missense_Mutation_p.W164C|PRKACA_uc002myd.2_3'UTR	NM_002730	NP_002721	P17612	KAPCA_HUMAN	cAMP-dependent protein kinase catalytic subunit	222	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|regulation of insulin secretion|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|cAMP-dependent protein kinase inhibitor activity|protein kinase binding			lung(1)	1						CCAGGGCCCACCAGTCCACGG	0.622			NA											12	36					3.07112e-06	4.05316e-06	0.000978	1	0
SFRS14	10147	broad.mit.edu	37	19	19115386	19115386	+	Silent	SNP	T	T	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr19:19115386T>A	uc002nkx.2	-	7	2666	c.2520A>T	c.(2518-2520)TCA>TCT	p.S840S	SFRS14_uc002nkz.1_Silent_p.S854S|SFRS14_uc002nla.1_Silent_p.S840S|SFRS14_uc002nlb.2_Silent_p.S840S|SFRS14_uc010xqk.1_Silent_p.S609S	NM_014884	NP_055699	Q8IX01	SUGP2_HUMAN	splicing factor, arginine/serine-rich 14	840					mRNA processing|RNA splicing	nucleus	RNA binding				0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)			TGAAACAAATTGATGGACATA	0.473			NA											7	99					0	0	0.00308	0	0
ZNF43	7594	broad.mit.edu	37	19	21991183	21991183	+	Silent	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr19:21991183G>T	uc002nqj.2	-	4	1786	c.1656C>A	c.(1654-1656)ATC>ATA	p.I552I	ZNF43_uc010ecv.2_Silent_p.I546I|ZNF43_uc002nql.2_Silent_p.I546I|ZNF43_uc002nqm.2_Silent_p.I546I|ZNF43_uc002nqk.2_Silent_p.I482I	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	552	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		GTTTGGTAAGGATTGAGAAAT	0.378			NA											11	43					2.80697e-09	4.45583e-09	0.000978	1	0
ZNF208	7757	broad.mit.edu	37	19	22155240	22155240	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr19:22155240A>G	uc002nqp.2	-	5	2445	c.2296T>C	c.(2296-2298)TGT>CGT	p.C766R	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GCTTTGCCACATTCTTCACAT	0.363			NA											7	57					0	0	0.001984	0	0
RYR1	6261	broad.mit.edu	37	19	39001314	39001314	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr19:39001314G>T	uc002oit.2	+	60	9145	c.9015G>T	c.(9013-9015)TTG>TTT	p.L3005F	RYR1_uc002oiu.2_Missense_Mutation_p.L3005F|RYR1_uc002oiv.1_5'UTR|RYR1_uc010xuf.1_5'Flank	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3005	Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGCTCCCTTTGATCAACCAGT	0.562			NA											54	186					2.83923e-41	5.37087e-41	0.00361	1	0
PSG6	5675	broad.mit.edu	37	19	43411932	43411932	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr19:43411932A>T	uc002ovj.1	-	4	833	c.781T>A	c.(781-783)TGT>AGT	p.C261S	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Missense_Mutation_p.C268S|PSG6_uc002ovi.2_Missense_Mutation_p.C262S|PSG6_uc010xwk.1_Missense_Mutation_p.C101S|PSG11_uc002ovk.1_Intron|PSG6_uc002ove.1_Missense_Mutation_p.C51S|PSG6_uc002ovf.1_Intron|PSG6_uc002ovg.1_Missense_Mutation_p.C261S	NM_002782	NP_002773	Q00889	PSG6_HUMAN	pregnancy specific beta-1-glycoprotein 6 isoform	261	Ig-like C2-type 2.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				TTAGGTTCACAGGTGAAGGCT	0.488			NA											16	285					0	0	0.004007	0	0
ZNF600	162966	broad.mit.edu	37	19	53268994	53268994	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr19:53268994T>A	uc002qab.3	-	3	2301	c.2015A>T	c.(2014-2016)GAC>GTC	p.D672V		NM_198457	NP_940859	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	672	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		AAAAGTCTTGTCACAAACCTT	0.388	Esophageal Squamous(196;1235 2112 2375 33339 34207)		NA											17	74					0	0	0.004007	0	0
NLRP12	91662	broad.mit.edu	37	19	54313519	54313519	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr19:54313519G>T	uc002qch.3	-	3	1614	c.1394C>A	c.(1393-1395)GCG>GAG	p.A465E	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.A465E|NLRP12_uc002qcj.3_Missense_Mutation_p.A465E|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.A465E	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	465	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CCCATCTGCCGCCAAGGAGCA	0.597			NA											10	76					3.86212e-05	4.92529e-05	0.008291	1	0
CACNG6	59285	broad.mit.edu	37	19	54515349	54515349	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr19:54515349T>A	uc002qct.2	+	4	1279	c.689T>A	c.(688-690)ATC>AAC	p.I230N	CACNG6_uc002qcu.2_Missense_Mutation_p.I184N|CACNG6_uc002qcv.2_Missense_Mutation_p.I159N	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	230	Helical; (Potential).					voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		GCCGGCCTGATCCTGCTGTTG	0.716			NA											14	70					0	0	0.00245	0	0
SOS1	6654	broad.mit.edu	37	2	39240608	39240608	+	Silent	SNP	T	T	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr2:39240608T>A	uc002rrk.3	-	13	2201	c.2160A>T	c.(2158-2160)ACA>ACT	p.T720T	SOS1_uc002rrj.3_Silent_p.T334T	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	720	N-terminal Ras-GEF.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				TACCTCTTACTGTTCCAATAA	0.343			NA							Noonan_syndrome				9	78					0	0	0.006214	0	0
SLC3A1	6519	broad.mit.edu	37	2	44547565	44547565	+	Silent	SNP	C	C	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr2:44547565C>G	uc002ruc.3	+	10	1923	c.1845C>G	c.(1843-1845)CCC>CCG	p.P615P	PREPL_uc002ruf.2_3'UTR|PREPL_uc002rug.2_3'UTR|PREPL_uc002ruh.2_3'UTR|PREPL_uc010fax.2_3'UTR|PREPL_uc002rui.3_3'UTR|PREPL_uc002ruj.1_3'UTR|PREPL_uc002ruk.1_3'UTR|SLC3A1_uc002rud.3_Silent_p.P337P|SLC3A1_uc002rue.3_Silent_p.P235P	NM_000341	NP_000332	Q07837	SLC31_HUMAN	solute carrier family 3, member 1	615	Extracellular (Potential).		P -> T (in CSNU1).		carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity				0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	CGGGCCTTCCCGCTAAAATGA	0.408			NA											8	75					0	0	0.00308	0	0
FSHR	2492	broad.mit.edu	37	2	49190356	49190356	+	Missense_Mutation	SNP	A	A	T	rs145815060		TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr2:49190356A>T	uc002rww.2	-	10	1678	c.1604T>A	c.(1603-1605)CTT>CAT	p.L535H	FSHR_uc002rwx.2_Missense_Mutation_p.L473H|FSHR_uc010fbn.2_Missense_Mutation_p.L509H	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	535	Helical; Name=5; (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	ATTGAGCACAAGGAGGGACAT	0.517			NA							Gonadal_Dysgenesis_46_XX				3	29					0	0	0.004672	0	0
RGPD4	285190	broad.mit.edu	37	2	108475895	108475895	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr2:108475895C>T	uc010ywk.1	+	11	1601	c.1519C>T	c.(1519-1521)CAC>TAC	p.H507Y	RGPD4_uc002tdu.2_5'UTR|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	507					intracellular transport		binding			skin(2)	2						ATGTAATTCTCACCACAGCTC	0.368			NA											14	164					0	0	0.003163	0	0
CCDC74A	90557	broad.mit.edu	37	2	132288319	132288319	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr2:132288319G>C	uc002tta.2	+	3	515	c.463G>C	c.(463-465)GGT>CGT	p.G155R	CCDC74A_uc002ttb.2_Intron	NM_138770	NP_620125	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	155										skin(1)	1						TCTTGCGGGCGGTAGCGCCGA	0.637			NA											5	70					0	0	0.000602	0	0
SPOPL	339745	broad.mit.edu	37	2	139308546	139308546	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr2:139308546A>C	uc002tvh.2	+	4	674	c.274A>C	c.(274-276)AGC>CGC	p.S92R		NM_001001664	NP_001001664	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	92	MATH.					nucleus				skin(2)|breast(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0296)		GCTTTTAGTCAGCTGCCCCAA	0.368			NA											6	96					0	0	0.00308	0	0
DYNC1I2	1781	broad.mit.edu	37	2	172549360	172549360	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr2:172549360A>T	uc002uha.1	+	3	347	c.182A>T	c.(181-183)GAA>GTA	p.E61V	DYNC1I2_uc002uhc.2_Missense_Mutation_p.E61V|DYNC1I2_uc002uhb.1_Missense_Mutation_p.E61V|DYNC1I2_uc010zds.1_Missense_Mutation_p.E61V|DYNC1I2_uc002uhd.1_Missense_Mutation_p.E61V|DYNC1I2_uc002uhe.1_Missense_Mutation_p.E61V|DYNC1I2_uc002uhf.1_Missense_Mutation_p.E61V|DYNC1I2_uc010zdt.1_Missense_Mutation_p.E61V	NM_001378	NP_001369	Q13409	DC1I2_HUMAN	dynein, cytoplasmic 1, intermediate chain 2	61					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|microtubule-based movement|transport	centrosome|cytosol|dynein complex|microtubule|vesicle	microtubule motor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.198)			AGAGAAGCTGAAGCATTGCTT	0.383			NA											5	11					0	0	0.000602	0	0
CHRNA1	1134	broad.mit.edu	37	2	175614801	175614801	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr2:175614801G>T	uc002ujd.2	-	8	1028	c.950C>A	c.(949-951)CCC>CAC	p.P317H	uc002uiw.2_Intron|CHRNA1_uc002uje.2_Missense_Mutation_p.P292H	NM_001039523	NP_001034612	P02708	ACHA_HUMAN	nicotinic cholinergic receptor alpha 1 isoform a	317					muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(2)|central_nervous_system(1)|skin(1)	4						TCCAATCAAGGGCACAGCACT	0.512			NA											10	50					3.07112e-06	4.05316e-06	0.000978	1	0
TTN	7273	broad.mit.edu	37	2	179595833	179595833	+	Silent	SNP	T	T	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr2:179595833T>A	uc010zfg.1	-	57	14051	c.13827A>T	c.(13825-13827)ACA>ACT	p.T4609T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.T1270T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5536							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCATTTGGCTGTAATCTCCT	0.418			NA											8	108					0	0	0.004482	0	0
SATB2	23314	broad.mit.edu	37	2	200213728	200213728	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr2:200213728T>A	uc002uuy.1	-	7	1686	c.869A>T	c.(868-870)CAG>CTG	p.Q290L	SATB2_uc010fsq.1_Missense_Mutation_p.Q172L|SATB2_uc002uuz.1_Missense_Mutation_p.Q290L|SATB2_uc002uva.1_Missense_Mutation_p.Q290L|SATB2_uc002uvb.1_Missense_Mutation_p.Q33L	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	290						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CATGATGGGCTGTAATGCGGG	0.493	Colon(30;262 767 11040 24421 36230)		NA											8	78					0	0	0.00308	0	0
PARD3B	117583	broad.mit.edu	37	2	206165275	206165275	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr2:206165275G>T	uc002var.1	+	17	2414	c.2207G>T	c.(2206-2208)GGT>GTT	p.G736V	PARD3B_uc010fub.1_Missense_Mutation_p.G736V|PARD3B_uc002vao.1_Missense_Mutation_p.G736V|PARD3B_uc002vap.1_Missense_Mutation_p.G674V|PARD3B_uc002vaq.1_Intron	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	736					cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		AAAGATTTTGGTCCAACTCTG	0.488			NA											24	96					6.21321e-17	1.12832e-16	0.00278	1	0
CHPF	79586	broad.mit.edu	37	2	220404988	220404988	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr2:220404988G>C	uc002vmc.3	-	4	1672	c.1445C>G	c.(1444-1446)ACT>AGT	p.T482S	CHPF_uc010zlh.1_Missense_Mutation_p.T320S	NM_024536	NP_078812	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	482	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding				0		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		CACTCGGCGAGTGAGGGGCCG	0.652			NA											5	22					0	0	0.000602	0	0
ALPPL2	251	broad.mit.edu	37	2	233272329	233272329	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr2:233272329C>A	uc002vss.3	+	4	379	c.326C>A	c.(325-327)CCA>CAA	p.P109Q		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	109					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	AAGCATGTGCCAGACAGTGGA	0.567			NA											3	29					2.56e-06	3.45905e-06	0.009096	1	0
AQP12B	653437	broad.mit.edu	37	2	241622051	241622051	+	Silent	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr2:241622051C>A	uc010fzj.2	-	1	267	c.204G>T	c.(202-204)GGG>GGT	p.G68G	AQP12B_uc002vzt.2_Intron	NM_001102467	NP_001095937	A6NM10	AQ12B_HUMAN	aquaporin 12B	56	Helical; Name=2; (Potential).					integral to membrane	transporter activity				0		all_epithelial(40;1.71e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		GCAGGTCAGGCCCAAAGTCCC	0.697			NA											7	41					0.000157383	0.000191048	0.00308	1	0
CDH22	64405	broad.mit.edu	37	20	44806629	44806629	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr20:44806629G>C	uc002xrm.2	-	10	2272	c.1871C>G	c.(1870-1872)CCC>CGC	p.P624R	CDH22_uc010ghk.1_Missense_Mutation_p.P624R	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	624	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				GAGGGCGCCGGGGCTGAGGGA	0.652			NA											4	33					0	0	0.001168	0	0
PCK1	5105	broad.mit.edu	37	20	56139639	56139639	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr20:56139639G>A	uc002xyn.3	+	8	1451	c.1288G>A	c.(1288-1290)GGC>AGC	p.G430S	PCK1_uc010zzm.1_Missense_Mutation_p.G113S	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	430					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			TCCCATTGAAGGCATTATCTT	0.567			NA											25	96					0	0	0.00278	0	0
MYO18B	84700	broad.mit.edu	37	22	26193997	26193997	+	Silent	SNP	C	C	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr22:26193997C>T	uc003abz.1	+	12	2704	c.2454C>T	c.(2452-2454)AGC>AGT	p.S818S	MYO18B_uc003aca.1_Silent_p.S699S|MYO18B_uc010guy.1_Silent_p.S699S|MYO18B_uc010guz.1_Silent_p.S699S|MYO18B_uc011aka.1_Intron|MYO18B_uc011akb.1_Silent_p.S331S	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	818	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						TCTCAGAGAGCGAGCAGCGGG	0.647			NA											10	46					0	0	0.008291	0	0
FGD5	152273	broad.mit.edu	37	3	14861995	14861996	+	Missense_Mutation	DNP	GC	GC	AG			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr3:14861995_14861996GC>AG	uc003bzc.2	+	1	1527_1528	c.1417_1418GC>AG	c.(1417-1419)GCG>AGG	p.A473R	FGD5_uc011avk.1_Missense_Mutation_p.A473R	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	473					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CCTGGTTCCCGCGGACAGGAAG	0.644			NA											4	39					0	0	0.004672	0	0
TBC1D23	55773	broad.mit.edu	37	3	100016840	100016840	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr3:100016840G>T	uc003dtt.2	+	9	1127	c.950G>T	c.(949-951)TGT>TTT	p.C317F	TBC1D23_uc003dts.2_Missense_Mutation_p.C317F	NM_018309	NP_060779	Q9NUY8	TBC23_HUMAN	TBC1 domain family, member 23	317						intracellular	Rab GTPase activator activity			ovary(1)|liver(1)	2						CAGGCTCTTTGTCTGGCCATC	0.403			NA											5	24					0.000602214	0.000704653	0.000602	1	0
SI	6476	broad.mit.edu	37	3	164735759	164735759	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr3:164735759C>T	uc003fei.2	-	29	3581	c.3519G>A	c.(3517-3519)ATG>ATA	p.M1173I		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1173	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TTGTTTTACCCATTGCATTGC	0.343			NA								HNSCC(35;0.089)			4	52					0	0	0.009096	0	0
ZBBX	79740	broad.mit.edu	37	3	167051692	167051692	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr3:167051692C>A	uc003fep.2	-	10	933	c.610G>T	c.(610-612)GAG>TAG	p.E204*	ZBBX_uc011bpc.1_Nonsense_Mutation_p.E204*|ZBBX_uc003feq.2_Nonsense_Mutation_p.E175*	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	204						intracellular	zinc ion binding			ovary(2)	2						GAATTATTCTCCTCTTTGGGT	0.333			NA											12	40					0.00136819	0.0015607	0.001368	1	0
CRIPAK	285464	broad.mit.edu	37	4	1389481	1389481	+	Silent	SNP	C	C	T	rs149222149	byFrequency	TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr4:1389481C>T	uc003gdf.2	+	1	4142	c.1182C>T	c.(1180-1182)CCC>CCT	p.P394P		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	394	Interaction with PAK1.				ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			GTGGAGTGCCCGCCTGCTCAC	0.612			NA											16	188					0	0	0.006122	0	0
GPR78	27201	broad.mit.edu	37	4	8588864	8588864	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr4:8588864C>A	uc003glk.2	+	3	1285	c.866C>A	c.(865-867)GCC>GAC	p.A289D	CPZ_uc003gll.2_Intron	NM_080819	NP_543009	Q96P69	GPR78_HUMAN	G protein-coupled receptor 78	289	Helical; Name=7; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(4)|ovary(2)	6						AAGGCGGTGGCCGACCCGTTC	0.677			NA											13	29					2.27111e-07	3.28371e-07	0.001368	1	0
SLC2A9	56606	broad.mit.edu	37	4	9836623	9836623	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr4:9836623G>T	uc003gmc.2	-	11	1362	c.1301C>A	c.(1300-1302)CCG>CAG	p.P434Q	SLC2A9_uc003gmd.2_Missense_Mutation_p.P405Q	NM_020041	NP_064425	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	434	Helical; Name=10; (Potential).				glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						CAAGATGAACGGGATGCCACC	0.542			NA											6	54					6.5536e-12	1.09387e-11	0.00308	1	0
AASDH	132949	broad.mit.edu	37	4	57220214	57220214	+	Silent	SNP	A	A	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr4:57220214A>G	uc003hbn.2	-	8	1527	c.1374T>C	c.(1372-1374)CTT>CTC	p.L458L	AASDH_uc010ihb.2_5'UTR|AASDH_uc011caa.1_Silent_p.L305L|AASDH_uc003hbo.2_Silent_p.L358L|AASDH_uc011cab.1_Intron|AASDH_uc010ihc.2_Silent_p.L458L|AASDH_uc003hbp.2_Silent_p.L458L	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	458					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				CCTGTTGCACAAGTTCAATGT	0.358			NA											5	41					0	0	0.001168	0	0
KIAA1109	84162	broad.mit.edu	37	4	123277052	123277052	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr4:123277052A>T	uc003ieh.2	+	81	14452	c.14407A>T	c.(14407-14409)AAC>TAC	p.N4803Y	KIAA1109_uc003iem.2_Missense_Mutation_p.N1159Y	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4803					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TTCTAGCTACAACCATGAAAC	0.398			NA											7	53					0	0	0.001984	0	0
NAF1	92345	broad.mit.edu	37	4	164085389	164085389	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr4:164085389T>C	uc003iqj.2	-	2	714	c.520A>G	c.(520-522)AAA>GAA	p.K174E	NAF1_uc010iqw.1_Missense_Mutation_p.K174E|NAF1_uc003iqk.2_RNA	NM_138386	NP_612395	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 homolog isoform a	174					rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			ovary(2)	2	all_hematologic(180;0.166)	Prostate(90;0.109)				AATTCATCTTTTGTTTTAAGA	0.274			NA											2	11					0	0	0.004672	0	0
VEGFC	7424	broad.mit.edu	37	4	177609073	177609073	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr4:177609073G>T	uc003ius.1	-	5	1143	c.713C>A	c.(712-714)GCA>GAA	p.A238E		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	238					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		CTTGTTCGCTGCCTGACACCT	0.448			NA											10	35					7.48243e-07	1.04846e-06	0.006214	1	0
CASP3	836	broad.mit.edu	37	4	185550429	185550429	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr4:185550429G>C	uc003iwh.2	-	8	1094	c.831C>G	c.(829-831)CAC>CAG	p.H277Q	CASP3_uc003iwg.2_3'UTR|CASP3_uc003iwi.2_Missense_Mutation_p.H277Q	NM_004346	NP_004337	P42574	CASP3_HUMAN	caspase 3 preproprotein	277					activation of caspase activity by cytochrome c|DNA fragmentation involved in apoptotic nuclear change|negative regulation of apoptosis|nerve growth factor receptor signaling pathway|nuclear fragmentation involved in apoptotic nuclear change|proteolysis|response to tumor necrosis factor	cytosol|mitochondrion|nucleoplasm|plasma membrane	cysteine-type endopeptidase activity|protein binding			kidney(1)	1		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.057)|all_hematologic(60;0.0592)		all cancers(43;2.05e-27)|Epithelial(43;4.27e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.04e-11)|Colorectal(24;2e-05)|STAD - Stomach adenocarcinoma(60;2.35e-05)|GBM - Glioblastoma multiforme(59;4.94e-05)|COAD - Colon adenocarcinoma(29;0.00017)|BRCA - Breast invasive adenocarcinoma(30;0.000218)|LUSC - Lung squamous cell carcinoma(40;0.00904)|READ - Rectum adenocarcinoma(43;0.161)	Melatonin(DB01065)|Minocycline(DB01017)|Simvastatin(DB00641)	CATTTCTTTAGTGATAAAAAT	0.348			NA											8	134					0	0	0.004482	0	0
SEMA5A	9037	broad.mit.edu	37	5	9066557	9066557	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:9066557C>A	uc003jek.2	-	17	2987	c.2275G>T	c.(2275-2277)GGC>TGC	p.G759C		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	759	TSP type-1 4.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						CCACTGGTGCCGTCGCTAGAA	0.517			NA											12	146					0.000978159	0.00113287	0.000978	1	0
RXFP3	51289	broad.mit.edu	37	5	33937383	33937383	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:33937383C>A	uc003jic.1	+	1	895	c.538C>A	c.(538-540)CGC>AGC	p.R180S		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	180	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						GAGTGTGACGCGCTACCATTC	0.627			NA											6	64					2.0095e-06	2.73147e-06	0.001984	1	0
SPEF2	79925	broad.mit.edu	37	5	35649461	35649461	+	Splice_Site	SNP	A	A	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:35649461A>G	uc003jjo.2	+	6	838	c.727_splice	c.e6-2	p.D243_splice	SPEF2_uc003jjn.1_Splice_Site_p.D243_splice|SPEF2_uc003jjq.3_Splice_Site_p.D243_splice	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1						nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTTTCTTTAAAGGATGTGGCT	0.303			NA											8	81					0	0	0.00308	0	0
GCNT4	51301	broad.mit.edu	37	5	74325583	74325583	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:74325583C>T	uc003kdn.2	-	1	1142	c.280G>A	c.(280-282)GAC>AAC	p.D94N		NM_016591	NP_057675	Q9P109	GCNT4_HUMAN	core 2 beta-1,6-N-acetylglucosaminyltransferase	94	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)|skin(1)	3		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		TCAATGATGTCCCTTCTTCTT	0.403			NA											13	151					0	0	0.001368	0	0
TTC37	9652	broad.mit.edu	37	5	94834075	94834075	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:94834075T>A	uc003klb.2	-	33	3832	c.3562A>T	c.(3562-3564)AGC>TGC	p.S1188C		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1188							binding			ovary(3)|pancreas(1)	4						AGAATTTACCTGTGAACAGCT	0.353			NA											16	104					0	0	0.00499	0	0
FBN2	2201	broad.mit.edu	37	5	127664387	127664387	+	Splice_Site	SNP	C	C	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:127664387C>T	uc003kuu.2	-	34	4910	c.4471_splice	c.e34+1	p.D1491_splice	FBN2_uc003kuv.2_Missense_Mutation_p.G1458D	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor						bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGGTGACCCACCTTGGCAGGA	0.507			NA											3	26					0	0	0.004672	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130766994	130766994	+	Silent	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:130766994C>A	uc003kvn.1	-	26	4229	c.4023G>T	c.(4021-4023)TCG>TCT	p.S1341S	RAPGEF6_uc003kvp.1_Silent_p.S1391S|RAPGEF6_uc003kvo.1_Silent_p.S1354S|RAPGEF6_uc010jdi.1_Silent_p.S1349S|RAPGEF6_uc010jdj.1_Silent_p.S1349S|RAPGEF6_uc003kvm.1_Silent_p.S264S	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	1341	Ser-rich.				Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		TGCTCACAGACGATGAGACAG	0.423	Melanoma(168;435 1955 13113 13877 23213)		NA											8	77					5.4927e-09	8.59892e-09	0.004482	1	0
PCDHB2	56133	broad.mit.edu	37	5	140475031	140475031	+	Silent	SNP	C	C	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:140475031C>G	uc003lil.2	+	1	795	c.657C>G	c.(655-657)GGC>GGG	p.G219G	PCDHB2_uc003lim.1_5'UTR	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	219	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCTAGATGGCGGGAGTCCAC	0.552			NA											6	39					0	0	0.001168	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482386	140482386	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:140482386G>T	uc003lio.2	+	1	2153	c.2153G>T	c.(2152-2154)AGG>ATG	p.R718M	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	718	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGAGGAGCAGGGCGGCCTCG	0.662			NA											16	159					1.00905e-13	1.7485e-13	0.008871	1	0
PCDHB4	56131	broad.mit.edu	37	5	140502251	140502251	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:140502251C>G	uc003lip.1	+	1	671	c.671C>G	c.(670-672)ACG>AGG	p.T224R		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	224	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGTCTGGCACGGTCATGGTT	0.547			NA											10	89					0	0	0.008291	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502701	140502701	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:140502701C>A	uc003lip.1	+	1	1121	c.1121C>A	c.(1120-1122)TCC>TAC	p.S374Y		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	374	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GATAGAGATTCCGGAGAAAAT	0.408			NA											17	121					1.5739e-10	2.57032e-10	0.004007	1	0
PCDHB8	56128	broad.mit.edu	37	5	140558333	140558333	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:140558333G>T	uc011dai.1	+	1	904	c.718G>T	c.(718-720)GCC>TCC	p.A240S	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	240	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAATGATAATGCCCCTGAATT	0.507			NA											26	391					1.17739e-12	2.00954e-12	0.005443	1	0
PCDHB9	56127	broad.mit.edu	37	5	140568214	140568214	+	Silent	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:140568214C>A	uc003liw.1	+	3	1323	c.1323C>A	c.(1321-1323)GTC>GTA	p.V441V		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	441	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTGCAGGTCTCCGACGTCA	0.587			NA											37	157					3.78316e-11	6.26844e-11	0.00623	1	0
PCDHB11	56125	broad.mit.edu	37	5	140581442	140581442	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:140581442T>C	uc003liy.2	+	1	2095	c.2095T>C	c.(2095-2097)TCG>CCG	p.S699P	PCDHB11_uc011daj.1_Missense_Mutation_p.S334P	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	699	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCGGTGTCTTCGCTCTTCCT	0.687			NA											15	178					0	0	0.004007	0	0
PCDHB18	54660	broad.mit.edu	37	5	140615613	140615613	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:140615613C>A	uc003ljc.1	+	1	1676	c.1328C>A	c.(1327-1329)CCG>CAG	p.P443Q		NR_001281				SubName: Full=Similar to protocadherin-3 (Pcdh3);											ovary(1)	1						CCCCAGGACCCGCACCTGCCC	0.642			NA											18	236					9.16793e-09	1.41573e-08	0.00499	1	0
PCDHGB6	56100	broad.mit.edu	37	5	140787938	140787938	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:140787938A>T	uc003lkj.1	+	1	169	c.169A>T	c.(169-171)AGT>TGT	p.S57C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.S57C	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	57	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTAGGGCTCAGTGTCCTGGA	0.597			NA											8	54					0	0	0.006214	0	0
SPINK5	11005	broad.mit.edu	37	5	147499581	147499581	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:147499581G>C	uc003lox.2	+	25	2396	c.2323G>C	c.(2323-2325)GAT>CAT	p.D775H	SPINK5_uc010jgr.2_Missense_Mutation_p.D756H|SPINK5_uc003low.2_Missense_Mutation_p.D775H|SPINK5_uc003loy.2_Missense_Mutation_p.D775H	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	775	Kazal-like 12.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATACATGTGATGAGTTTAG	0.393			NA											8	24					0	0	0.00308	0	0
ODZ2	57451	broad.mit.edu	37	5	167643912	167643912	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:167643912C>A	uc010jjd.2	+	22	4191	c.4191C>A	c.(4189-4191)AGC>AGA	p.S1397R	ODZ2_uc003lzr.3_Missense_Mutation_p.S1167R|ODZ2_uc003lzt.3_Missense_Mutation_p.S770R|ODZ2_uc010jje.2_Missense_Mutation_p.S661R	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		GTGATTCCAGCATGGATGTAG	0.527			NA											14	80					3.27435e-08	4.95519e-08	0.00245	1	0
FAF2	23197	broad.mit.edu	37	5	175927110	175927110	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:175927110G>T	uc003mej.3	+	10	1171	c.1118G>T	c.(1117-1119)CGA>CTA	p.R373L		NM_014613	NP_055428	Q96CS3	FAF2_HUMAN	UBX domain containing 8	373	UBX.				response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			ovary(1)	1						AATGATTCTCGAGTAGAGAGA	0.438			NA											8	103					0.000442599	0.000526021	0.006214	1	0
DSP	1832	broad.mit.edu	37	6	7584233	7584233	+	Silent	SNP	T	T	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr6:7584233T>A	uc003mxp.1	+	24	7017	c.6738T>A	c.(6736-6738)GTT>GTA	p.V2246V	DSP_uc003mxq.1_Silent_p.V1647V	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2246	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		ATGACGAGGTTGGTGAGAGAA	0.443			NA											14	33					0	0	0.001855	0	0
PIP5K1P1	206426	broad.mit.edu	37	6	7986871	7986871	+	Silent	SNP	C	C	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr6:7986871C>T	uc003mxx.3	+	1	537	c.102C>T	c.(100-102)AGC>AGT	p.S34S	TXNDC5_uc003mxw.2_Intron	NR_027712				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						GAATCTTGAGCCCCACGGCAT	0.557			NA											7	18					0	0	0.001984	0	0
ZNF451	26036	broad.mit.edu	37	6	57013339	57013339	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr6:57013339G>T	uc003pdm.1	+	10	2680	c.2456G>T	c.(2455-2457)AGT>ATT	p.S819I	ZNF451_uc003pdl.2_Missense_Mutation_p.S819I|ZNF451_uc003pdn.1_Missense_Mutation_p.S819I|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.S819I	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	819					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			CAGAAACCCAGTGTGGCTCAT	0.398			NA											8	46					0.000274275	0.000327687	0.004482	1	0
COL19A1	1310	broad.mit.edu	37	6	70812089	70812089	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr6:70812089G>T	uc003pfc.1	+	16	1370	c.1253G>T	c.(1252-1254)GGA>GTA	p.G418V	COL19A1_uc010kam.1_Missense_Mutation_p.G314V	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	418	Triple-helical region 2 (COL2).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GGACCTCCCGGAAAACCAGGA	0.373			NA											7	89					5.18039e-06	6.79739e-06	0.00308	1	0
GRIK2	2898	broad.mit.edu	37	6	102307276	102307276	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr6:102307276T>C	uc003pqp.3	+	10	1681	c.1432T>C	c.(1432-1434)TAT>CAT	p.Y478H	GRIK2_uc003pqn.2_Missense_Mutation_p.Y478H|GRIK2_uc003pqo.3_Missense_Mutation_p.Y478H|GRIK2_uc010kcw.2_Missense_Mutation_p.Y478H	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	478	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TGGCTTTACATATGAAATTAG	0.393			NA											9	56					0	0	0.006214	0	0
RFX6	222546	broad.mit.edu	37	6	117237203	117237203	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr6:117237203C>A	uc003pxm.2	+	8	876	c.813C>A	c.(811-813)CAC>CAA	p.H271Q		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	271					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						ACAAAACTCACTGCCAGTGTA	0.323			NA											12	57					4.3838e-07	6.21952e-07	0.001855	1	0
ROS1	6098	broad.mit.edu	37	6	117665282	117665282	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr6:117665282C>A	uc003pxp.1	-	27	4664	c.4465G>T	c.(4465-4467)GTT>TTT	p.V1489F	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1489	Extracellular (Potential).|Fibronectin type-III 6.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GCATAATAAACCAGGTATGTT	0.398			NA	T	GOPC|ROS1	glioblastoma|NSCLC								4	56					1.024e-07	1.51927e-07	0.000602	1	0
CLVS2	134829	broad.mit.edu	37	6	123377007	123377007	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr6:123377007C>G	uc003pzi.1	+	5	1601	c.732C>G	c.(730-732)ATC>ATG	p.I244M		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	244	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						ATCCTGAGATCCTGCCCTCTG	0.453			NA											5	79					0	0	0.001168	0	0
MOXD1	26002	broad.mit.edu	37	6	132695862	132695862	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr6:132695862G>A	uc003qdf.2	-	2	418	c.319C>T	c.(319-321)CAT>TAT	p.H107Y	MOXD1_uc003qde.2_Missense_Mutation_p.H39Y	NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1 isoform 2	107	Lumenal (Potential).|DOMON.				catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			ovary(1)	1	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		TATTCTAGATGGTAATCTTGC	0.338			NA											9	67					0	0	0.006214	0	0
GPNMB	10457	broad.mit.edu	37	7	23293804	23293804	+	Silent	SNP	G	G	A	rs149206943		TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr7:23293804G>A	uc003swc.2	+	3	401	c.240G>A	c.(238-240)GCG>GCA	p.A80A	GPNMB_uc003swa.2_Silent_p.A80A|GPNMB_uc003swb.2_Silent_p.A80A|GPNMB_uc011jyy.1_Silent_p.A80A|GPNMB_uc011jyz.1_Intron	NM_001005340	NP_001005340	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb isoform a	80	Extracellular (Potential).				negative regulation of cell proliferation	melanosome				ovary(3)|breast(2)	5			GBM - Glioblastoma multiforme(13;0.154)			GTGTGCAGGCGGTCCTGACCA	0.453			NA											15	106					0	0	0.004007	0	0
NPSR1	387129	broad.mit.edu	37	7	34851388	34851388	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr7:34851388C>A	uc003teg.1	+	4	519	c.391C>A	c.(391-393)CTG>ATG	p.L131M	AAA1_uc010kwq.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Missense_Mutation_p.L131M|NPSR1_uc010kwt.1_Translation_Start_Site|NPSR1_uc010kwu.1_Intron|NPSR1_uc010kwv.1_Intron|NPSR1_uc003tei.1_Missense_Mutation_p.L131M|NPSR1_uc010kww.1_Missense_Mutation_p.L120M|NPSR1_uc011kar.1_Intron|AAA1_uc010kwy.2_Intron|AAA1_uc003tek.3_Intron	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	131	Helical; Name=3; (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	TTAGGTTGTGCTGCTCTACGC	0.468			NA											12	81					7.03913e-09	1.09444e-08	0.001368	1	0
WBSCR28	135886	broad.mit.edu	37	7	73279468	73279468	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr7:73279468T>A	uc003tzk.2	+	2	254	c.218T>A	c.(217-219)CTG>CAG	p.L73Q	RFC2_uc011kfa.1_Intron|WBSCR28_uc003tzl.2_5'UTR	NM_182504	NP_872310	Q6UE05	WBS28_HUMAN	hypothetical protein LOC135886	73	Helical; (Potential).					integral to membrane				breast(1)	1		Lung NSC(55;0.159)				GCCTGCCCCCTGGGCCAGGCT	0.672			NA											8	123					0	0	0.00308	0	0
ABCB1	5243	broad.mit.edu	37	7	87190601	87190601	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr7:87190601C>T	uc003uiz.1	-	9	1223	c.805G>A	c.(805-807)GGA>AGA	p.G269R	ABCB1_uc011khc.1_Missense_Mutation_p.G205R	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	269	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TTCTTTTGTCCTCCAAATGCA	0.353			NA											6	26					0	0	0.001168	0	0
ZNF804B	219578	broad.mit.edu	37	7	88964765	88964765	+	Silent	SNP	G	G	A	rs148990105		TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr7:88964765G>A	uc011khi.1	+	4	3007	c.2469G>A	c.(2467-2469)ACG>ACA	p.T823T		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	823						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TAAAATCTACGAGAATCATCT	0.363			NA								HNSCC(36;0.09)			4	57					0	0	0.000602	0	0
ZNF655	79027	broad.mit.edu	37	7	99170705	99170705	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr7:99170705A>G	uc003urh.2	+	3	1367	c.974A>G	c.(973-975)CAC>CGC	p.H325R	ZNF655_uc010lga.2_Missense_Mutation_p.H360R|ZNF655_uc010lgc.2_Missense_Mutation_p.H360R|ZNF655_uc003urj.2_Missense_Mutation_p.H325R|ZNF655_uc003urk.2_Missense_Mutation_p.H162R|ZNF655_uc010lgd.2_Missense_Mutation_p.H162R	NM_138494	NP_612503	Q8N720	ZN655_HUMAN	zinc finger protein 655 isoform a	325	C2H2-type 3.				G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					CAGAAAATTCACAAAGAGATG	0.413			NA											21	101					0	0	0.002299	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121701174	121701174	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr7:121701174T>A	uc003vjy.2	+	30	7243	c.6848T>A	c.(6847-6849)GTG>GAG	p.V2283E	PTPRZ1_uc003vjz.2_Missense_Mutation_p.V1416E|PTPRZ1_uc011knt.1_Missense_Mutation_p.V873E	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	2283	Cytoplasmic (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						CTCAGCCTTGTGAGCACAAGG	0.428			NA											13	42					0	0	0.001855	0	0
C7orf45	136263	broad.mit.edu	37	7	129847876	129847876	+	Silent	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr7:129847876G>T	uc003vpp.2	+	1	173	c.126G>T	c.(124-126)CTG>CTT	p.L42L	TMEM209_uc003vpn.2_5'Flank|TMEM209_uc010lmc.1_5'Flank|TMEM209_uc003vpo.2_5'Flank	NM_145268	NP_660311	Q8WWF3	CG045_HUMAN	hypothetical protein LOC136263	42	Helical; (Potential).					integral to membrane					0	Melanoma(18;0.0435)					GGAGCTTCCTGCTTTGGTATT	0.398			NA											21	103					1.36565e-18	2.52034e-18	0.00278	1	0
SVOPL	136306	broad.mit.edu	37	7	138312982	138312982	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr7:138312982G>C	uc011kqh.1	-	10	990	c.990C>G	c.(988-990)AGC>AGG	p.S330R	SVOPL_uc003vue.2_Missense_Mutation_p.S178R	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	330						integral to membrane	transmembrane transporter activity				0						AGGGGCTCTGGCTCTCCCCTG	0.572			NA											6	36					0	0	0.001168	0	0
CSMD1	64478	broad.mit.edu	37	8	2967820	2967820	+	Silent	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr8:2967820G>T	uc011kwk.1	-	43	6861	c.6471C>A	c.(6469-6471)ACC>ACA	p.T2157T	CSMD1_uc011kwj.1_Silent_p.T1549T|CSMD1_uc010lrg.2_Silent_p.T225T	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2157	Extracellular (Potential).|CUB 13.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GGGAGTAGATGGTGCCGTTCT	0.488			NA											5	9					3.59834e-05	4.64104e-05	0.001168	1	0
SDC2	6383	broad.mit.edu	37	8	97605786	97605786	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr8:97605786G>T	uc003yhv.1	+	2	757	c.139G>T	c.(139-141)GAT>TAT	p.D47Y	SDC2_uc011lgu.1_Missense_Mutation_p.D18Y	NM_002998	NP_002989	P34741	SDC2_HUMAN	syndecan 2 precursor	47	Extracellular (Potential).					integral to plasma membrane	cytoskeletal protein binding|PDZ domain binding			ovary(2)	2	Breast(36;3.41e-05)				Sargramostim(DB00020)	GTATCCTATTGATGACGATGA	0.478			NA											12	65					1.5842e-08	2.42982e-08	0.001855	1	0
KCNS2	3788	broad.mit.edu	37	8	99441377	99441377	+	Silent	SNP	T	T	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr8:99441377T>A	uc003yin.2	+	2	1520	c.1170T>A	c.(1168-1170)ACT>ACA	p.T390T		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	390	Helical; Name=Segment S6; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			GAAAGCTGACTGCCTCTGCCT	0.592	Pancreas(138;844 2489 9202 24627)		NA											14	97					0	0	0.001855	0	0
RIMS2	9699	broad.mit.edu	37	8	105026764	105026764	+	Silent	SNP	A	A	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr8:105026764A>T	uc003yls.2	+	17	2716	c.2475A>T	c.(2473-2475)ACA>ACT	p.T825T	RIMS2_uc003ylp.2_Silent_p.T1085T|RIMS2_uc003ylw.2_Silent_p.T899T|RIMS2_uc003ylq.2_Silent_p.T899T|RIMS2_uc003ylr.2_Silent_p.T924T	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1147					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding	p.H825L(1)		ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CTGTCCAGACAAGCCCATCAA	0.413			NA								HNSCC(12;0.0054)			6	47					0	0	0.001984	0	0
CSMD3	114788	broad.mit.edu	37	8	113301663	113301663	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr8:113301663G>T	uc003ynu.2	-	57	9238	c.9079C>A	c.(9079-9081)CTT>ATT	p.L3027I	CSMD3_uc003yns.2_Missense_Mutation_p.L2229I|CSMD3_uc003ynt.2_Missense_Mutation_p.L2987I|CSMD3_uc011lhx.1_Missense_Mutation_p.L2858I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3027	Sushi 21.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGGCCTAAAAGGGAACGCTTT	0.468			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			25	76					1.85244e-09	2.9823e-09	0.00333	1	0
KCNK9	51305	broad.mit.edu	37	8	140630797	140630797	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr8:140630797C>T	uc003yvf.1	-	2	893	c.829G>A	c.(829-831)GAG>AAG	p.E277K	KCNK9_uc003yvg.1_Missense_Mutation_p.E277K|KCNK9_uc003yve.1_RNA	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	277	Cytoplasmic (Potential).					integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			CGCGGCTCCTCAGGGATGTGA	0.642			NA											4	51					0	0	0.009096	0	0
RANBP6	26953	broad.mit.edu	37	9	6012550	6012550	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr9:6012550T>C	uc003zjr.2	-	1	3069	c.3058A>G	c.(3058-3060)ACT>GCT	p.T1020A	RANBP6_uc011lmf.1_Missense_Mutation_p.T668A|RANBP6_uc003zjs.2_Missense_Mutation_p.T608A	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	1020					protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		AAACTCAAAGTCTGAATAGCT	0.363			NA											9	51					0	0	0.004482	0	0
IFNA6	3443	broad.mit.edu	37	9	21350855	21350855	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr9:21350855A>G	uc011lni.1	-	1	32	c.32T>C	c.(31-33)CTG>CCG	p.L11P		NM_021002	NP_066282	P05013	IFNA6_HUMAN	interferon, alpha 6 precursor	11					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		GAGCACCACCAGGGCCATCAG	0.522			NA											12	84					0	0	0.001855	0	0
FAM75A6	389730	broad.mit.edu	37	9	43627630	43627630	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr9:43627630G>T	uc011lrb.1	-	4	1086	c.1057C>A	c.(1057-1059)CAA>AAA	p.Q353K		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	353						integral to membrane					0						GGGGTCATTTGATTTGTAAAT	0.433			NA											81	220					8.6838e-40	1.62911e-39	0.00361	1	0
GDA	9615	broad.mit.edu	37	9	74860078	74860078	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr9:74860078G>A	uc004aiq.2	+	12	1333	c.1150G>A	c.(1150-1152)GGT>AGT	p.G384S	GDA_uc011lse.1_Missense_Mutation_p.G310S|GDA_uc011lsf.1_Missense_Mutation_p.G310S|GDA_uc004air.2_Missense_Mutation_p.G384S|GDA_uc010mow.1_RNA|GDA_uc004ais.2_Missense_Mutation_p.G306S	NM_004293	NP_004284	Q9Y2T3	GUAD_HUMAN	guanine deaminase	384					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		GGGGCTGGATGGTGAGATTGG	0.448			NA											24	89					0	0	0.004656	0	0
VPS13A	23230	broad.mit.edu	37	9	79984229	79984229	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr9:79984229G>T	uc004akr.2	+	63	8828	c.8568G>T	c.(8566-8568)ATG>ATT	p.M2856I	VPS13A_uc004akp.3_Missense_Mutation_p.M2856I|VPS13A_uc004akq.3_Missense_Mutation_p.M2856I|VPS13A_uc004aks.2_Missense_Mutation_p.M2817I	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	2856					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						TTAAGCAGATGTATGTACTCA	0.299			NA											22	82					2.21704e-12	3.75572e-12	0.00278	1	0
GRIN3A	116443	broad.mit.edu	37	9	104433094	104433094	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr9:104433094C>T	uc004bbp.1	-	3	2201	c.1600G>A	c.(1600-1602)GAA>AAA	p.E534K	GRIN3A_uc004bbq.1_Missense_Mutation_p.E534K	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	534	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CACAAGCCTTCATCATCTACC	0.473			NA											26	57					0	0	0.00333	0	0
GRIN3A	116443	broad.mit.edu	37	9	104433100	104433100	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr9:104433100C>A	uc004bbp.1	-	3	2195	c.1594G>T	c.(1594-1596)GAT>TAT	p.D532Y	GRIN3A_uc004bbq.1_Missense_Mutation_p.D532Y	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	532	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CCTTCATCATCTACCTCCCTT	0.488			NA											26	63					5.45024e-15	9.59073e-15	0.00333	1	0
ABCA1	19	broad.mit.edu	37	9	107578428	107578428	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr9:107578428T>C	uc004bcl.2	-	25	4047	c.3734A>G	c.(3733-3735)GAA>GGA	p.E1245G		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	1245					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ACTTACTTCTTCCAGGGTCGT	0.488			NA											37	151					0	0	0.00623	0	0
AMBP	259	broad.mit.edu	37	9	116836424	116836424	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr9:116836424T>C	uc004bie.3	-	4	609	c.346A>G	c.(346-348)ATA>GTA	p.I116V	AMBP_uc011lxk.1_Missense_Mutation_p.I57V|AMBP_uc010mvc.1_RNA	NM_001633	NP_001624	P02760	AMBP_HUMAN	alpha-1-microglobulin/bikunin preproprotein	116					cell adhesion|female pregnancy|heme catabolic process|interspecies interaction between organisms|negative regulation of immune response|negative regulation of JNK cascade|protein-chromophore linkage	extracellular region|plasma membrane	calcium channel inhibitor activity|calcium oxalate binding|heme binding|IgA binding|protein homodimerization activity|serine-type endopeptidase inhibitor activity|transporter activity			skin(1)	1					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	TCCATGGTTATGTTCCATTCT	0.493			NA											9	30					0	0	0.008291	0	0
DBC1	1620	broad.mit.edu	37	9	122011272	122011272	+	Nonsense_Mutation	SNP	G	G	T	rs115548564	by1000genomes	TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr9:122011272G>T	uc004bkc.2	-	3	831	c.375C>A	c.(373-375)TAC>TAA	p.Y125*	DBC1_uc004bkd.2_Nonsense_Mutation_p.Y125*	NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	125	MACPF.				cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						GGTGGGTGCCGTACTTTTTGA	0.562			NA											15	37					0.00316338	0.00357257	0.003163	1	0
NOTCH1	4851	broad.mit.edu	37	9	139413985	139413985	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr9:139413985C>T	uc004chz.2	-	5	775	c.775G>A	c.(775-777)GAC>AAC	p.D259N		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	259	Extracellular (Potential).|EGF-like 7; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGACAATCGTCGATATTTTCC	0.627			NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			12	164					0	0	0.000978	0	0
DDX53	168400	broad.mit.edu	37	X	23019760	23019760	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chrX:23019760G>A	uc004daj.2	+	1	1674	c.1586G>A	c.(1585-1587)CGA>CAA	p.R529Q		NM_182699	NP_874358	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	529	Helicase C-terminal.					nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			large_intestine(1)|ovary(1)|kidney(1)	3						ATAGTATCCCGAGGTCTTGAT	0.383			NA											6	129					0	0	0.001984	0	0
PDK3	5165	broad.mit.edu	37	X	24523382	24523382	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chrX:24523382G>C	uc004dbg.2	+	5	791	c.562G>C	c.(562-564)GAT>CAT	p.D188H	PDK3_uc004dbh.2_Missense_Mutation_p.D188H	NM_005391	NP_005382	Q15120	PDK3_HUMAN	pyruvate dehydrogenase kinase 3 isoform 2	188	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|protein binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						AGGAAGTATCGATCCCACCTG	0.453			NA											8	72					0	0	0.006214	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29417272	29417272	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chrX:29417272G>C	uc004dby.2	+	5	1058	c.550G>C	c.(550-552)GAA>CAA	p.E184Q		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	184	Ig-like C2-type 2.|Extracellular (Potential).				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						CTTCATATAGGAATGCAGGAC	0.294			NA											4	68					0	0	0.000602	0	0
ZNF182	7569	broad.mit.edu	37	X	47836373	47836373	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chrX:47836373C>A	uc004dir.2	-	7	1459	c.1113G>T	c.(1111-1113)AAG>AAT	p.K371N	ZNF182_uc004dis.2_Missense_Mutation_p.K352N|ZNF182_uc004dit.2_Missense_Mutation_p.K371N|ZNF182_uc011mlu.1_Missense_Mutation_p.K351N	NM_006962	NP_008893	P17025	ZN182_HUMAN	zinc finger protein 21 isoform 1	371					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3						CATGGGGTTTCTTTCCTGTAT	0.363			NA											7	128					1.12685e-05	1.47009e-05	0.004482	1	0
BMP15	9210	broad.mit.edu	37	X	50659497	50659497	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chrX:50659497T>G	uc011mnw.1	+	2	1069	c.1069T>G	c.(1069-1071)TGT>GGT	p.C357G		NM_005448	NP_005439	O95972	BMP15_HUMAN	bone morphogenetic protein 15 precursor	357					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			ovary(2)	2	Ovarian(276;0.236)					CCGGCCCTCCTGTGTCCCGTA	0.463			NA											13	89					0	0	0.001855	0	0
IQSEC2	23096	broad.mit.edu	37	X	53280041	53280041	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chrX:53280041G>A	uc004dsd.2	-	5	1918	c.1717C>T	c.(1717-1719)CGC>TGC	p.R573C	IQSEC2_uc004dsc.2_Missense_Mutation_p.R368C	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	563	Pro-rich.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						GGACCCCTGCGAGTGCCTTCC	0.677			NA											8	18					0	0	0.00308	0	0
ZDHHC15	158866	broad.mit.edu	37	X	74644525	74644525	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chrX:74644525T>G	uc004ecg.2	-	8	1176	c.698A>C	c.(697-699)TAC>TCC	p.Y233S	ZDHHC15_uc004ech.2_Missense_Mutation_p.Y224S|ZDHHC15_uc011mqo.1_RNA	NM_144969	NP_659406	Q96MV8	ZDH15_HUMAN	zinc finger, DHHC-type containing 15 isoform 1	233						integral to membrane	zinc ion binding			ovary(2)	2						CCAACAATGGTAACCAAAGAG	0.393			NA											3	21					0	0	0.004672	0	0
ATRX	546	broad.mit.edu	37	X	76855002	76855002	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chrX:76855002C>T	uc004ecp.3	-	25	6066	c.5834G>A	c.(5833-5835)GGA>GAA	p.G1945E	ATRX_uc004ecq.3_Missense_Mutation_p.G1907E|ATRX_uc004eco.3_Missense_Mutation_p.G1730E	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1945	Poly-Ser.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	ACTGCCACTTCCACTTGAGCT	0.333			NA	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						44	383					0	0	0.00361	0	0
P2RY10	27334	broad.mit.edu	37	X	78216671	78216671	+	Silent	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chrX:78216671C>A	uc004ede.2	+	4	1023	c.654C>A	c.(652-654)ACC>ACA	p.T218T	P2RY10_uc004edf.2_Silent_p.T218T	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	218	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						CATGGTGTACCTGGAAAACTA	0.478			NA											10	44					3.07112e-06	4.05316e-06	0.000978	1	0
COL4A6	1288	broad.mit.edu	37	X	107431764	107431764	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chrX:107431764C>A	uc004enw.3	-	21	1676	c.1573G>T	c.(1573-1575)GGC>TGC	p.G525C	COL4A6_uc004env.3_Missense_Mutation_p.G524C|COL4A6_uc011msn.1_Missense_Mutation_p.G524C|COL4A6_uc010npk.2_Missense_Mutation_p.G524C	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	525	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						CCTGCTGGGCCCTGTGCACCC	0.572	Melanoma(87;1895 1945 2589 7165)		NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				6	56					2.0095e-06	2.73147e-06	0.001984	1	0
OR10Z1	128368	broad.mit.edu	37	1	158576398	158576398	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:158576398delC	uc010pio.1	+	1	170	c.170delC	c.(169-171)ACCfs	p.T57fs		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	57	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					CATCTGCACACCCCCATGTAC	0.517			NA											17	343	---	---	---	---	NA	NA	NA	NA	NA
LY9	4063	broad.mit.edu	37	1	160793397	160793398	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:160793397_160793398insA	uc001fwu.2	+	8	1691_1692	c.1641_1642insA	c.(1639-1644)GAGGACfs	p.E547fs	LY9_uc001fwv.2_Frame_Shift_Ins_p.E533fs|LY9_uc001fww.2_Frame_Shift_Ins_p.E457fs|LY9_uc001fwx.2_Frame_Shift_Ins_p.E457fs|LY9_uc001fwy.1_Frame_Shift_Ins_p.E345fs|LY9_uc001fwz.2_Frame_Shift_Ins_p.E185fs	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	547_548	Cytoplasmic (Potential).				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			AGGAGGATGAGGACAGGCCTGA	0.584			NA											9	98	---	---	---	---	NA	NA	NA	NA	NA
NLRP3	114548	broad.mit.edu	37	1	247588812	247588812	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr1:247588812delG	uc001icr.2	+	5	2205	c.2067delG	c.(2065-2067)AAGfs	p.K689fs	NLRP3_uc001ics.2_Frame_Shift_Del_p.K689fs|NLRP3_uc001icu.2_Frame_Shift_Del_p.K689fs|NLRP3_uc001icw.2_Frame_Shift_Del_p.K689fs|NLRP3_uc001icv.2_Frame_Shift_Del_p.K689fs|NLRP3_uc010pyw.1_Frame_Shift_Del_p.K687fs|NLRP3_uc001ict.1_Frame_Shift_Del_p.K687fs	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	689					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			ACATGCCCAAGGAGGAAGAGG	0.512			NA											7	59	---	---	---	---	NA	NA	NA	NA	NA
CNOT1	23019	broad.mit.edu	37	16	58620484	58620503	+	Frame_Shift_Del	DEL	TCTTGTCCAACTCCAAAGGC	TCTTGTCCAACTCCAAAGGC	-			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	TCTTGTCCAACTCCAAAGGC	TCTTGTCCAACTCCAAAGGC	-	-	TCTTGTCCAACTCCAAAGGC	TCTTGTCCAACTCCAAAGGC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr16:58620484_58620503delTCTTGTCCAACTCCAAAGGC	uc002env.2	-	7	876_895	c.583_602delGCCTTTGGAGTTGGACAAGA	c.(583-603)GCCTTTGGAGTTGGACAAGAAfs	p.A195fs	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Frame_Shift_Del_p.A195fs|CNOT1_uc002enx.2_Frame_Shift_Del_p.A195fs|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	195_201					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GTCTATCTGTTCTTGTCCAACTCCAAAGGCTCCCTTCTGC	0.491			NA											42	297	---	---	---	---	NA	NA	NA	NA	NA
WDR62	284403	broad.mit.edu	37	19	36583666	36583668	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	GCA	GCA	-	-	GCA	GCA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr19:36583666_36583668delGCA	uc002odc.2	+	19	2377_2379	c.2286_2288delGCA	c.(2284-2289)CGGCAG>CGG	p.Q766del	WDR62_uc002odd.2_In_Frame_Del_p.Q766del	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	766					cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TTGACCACCGGCAGCAGCAGCAG	0.567			NA											7	130	---	---	---	---	NA	NA	NA	NA	NA
ZNF142	7701	broad.mit.edu	37	2	219508459	219508459	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr2:219508459delG	uc002vin.2	-	8	3216	c.2780delC	c.(2779-2781)CCAfs	p.P927fs	ZNF142_uc002vil.2_Frame_Shift_Del_p.P888fs|ZNF142_uc010fvt.2_Frame_Shift_Del_p.P764fs|ZNF142_uc002vim.2_Frame_Shift_Del_p.P764fs	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	927					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		TGATGCAGGTGGGGGCTTCCC	0.547	Colon(170;867 1942 8995 15834 18053)		NA											31	185	---	---	---	---	NA	NA	NA	NA	NA
SPEG	10290	broad.mit.edu	37	2	220313626	220313626	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr2:220313626delG	uc010fwg.2	+	4	1746	c.1746delG	c.(1744-1746)CCGfs	p.P582fs	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_5'UTR|SPEG_uc002vln.1_5'UTR|SPEG_uc002vlp.1_5'Flank	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	582	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GGACAGAGCCGGGGGAAGGCC	0.771			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
MEI1	150365	broad.mit.edu	37	22	42110055	42110055	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr22:42110055delC	uc003baz.1	+	4	424	c.399delC	c.(397-399)TGCfs	p.C133fs	MEI1_uc003bay.3_Frame_Shift_Del_p.C133fs|MEI1_uc011apd.1_RNA	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	133							binding			central_nervous_system(1)|skin(1)	2						CTATCCGTTGCCTGCTGGATG	0.363			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
FAM71B	153745	broad.mit.edu	37	5	156589877	156589877	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr5:156589877delG	uc003lwn.2	-	2	1499	c.1399delC	c.(1399-1401)CACfs	p.H467fs		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	467						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GCGGACCGGTGGGAAGACGCT	0.517			NA											14	167	---	---	---	---	NA	NA	NA	NA	NA
TMEM67	91147	broad.mit.edu	37	8	94821088	94821088	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr8:94821088delA	uc011lgk.1	+	24	2531	c.2460delA	c.(2458-2460)AGAfs	p.R820fs	TMEM67_uc010maw.2_Frame_Shift_Del_p.R526fs|TMEM67_uc003yga.3_Frame_Shift_Del_p.R739fs|TMEM67_uc011lgl.1_Frame_Shift_Del_p.R219fs	NM_153704	NP_714915	Q5HYA8	MKS3_HUMAN	meckelin isoform 1	820			R -> S (in COACHS).		cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			ovary(2)	2	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			GTAGCCAGAGAGGTTTGGTAC	0.313			NA											14	79	---	---	---	---	NA	NA	NA	NA	NA
SQLE	6713	broad.mit.edu	37	8	126011893	126011893	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr8:126011893delC	uc011liq.1	+	1	1174	c.248delC	c.(247-249)TCCfs	p.S83fs		NM_003129	NP_003120	Q14534	ERG1_HUMAN	squalene epoxidase	83					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome	flavin adenine dinucleotide binding|squalene monooxygenase activity			ovary(1)|breast(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)		Butenafine(DB01091)|Naftifine(DB00735)|Terbinafine(DB00857)	TGGGCCAAATCCCCCCCTGAA	0.547			NA											7	36	---	---	---	---	NA	NA	NA	NA	NA
SUSD1	64420	broad.mit.edu	37	9	114842405	114842405	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7672-01A-11D-2063-08	TCGA-44-7672-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9982bd67-c7eb-4c68-b9c4-2907ef244790	df1444af-0bbc-4596-863f-47afa29cae67	g.chr9:114842405delG	uc004bfu.2	-	11	1556	c.1515delC	c.(1513-1515)ACCfs	p.T505fs	SUSD1_uc010mui.2_Frame_Shift_Del_p.T505fs|SUSD1_uc010muj.2_Frame_Shift_Del_p.T505fs	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	505	Extracellular (Potential).					integral to membrane	calcium ion binding				0						ATCTCAAGCAGGTTTCATTAA	0.338			NA											7	83	---	---	---	---	NA	NA	NA	NA	NA
