Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ACTRT2	140625	broad.mit.edu	37	1	2939237	2939237	+	Silent	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:2939237C>A	uc001ajz.2	+	1	1192	c.987C>A	c.(985-987)ATC>ATA	p.I329I		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	329						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		ACACCCCCATCAAGATCACGG	0.622			NA											25	78					3.78316e-11	5.06249e-11	0.00623	1	0
CSMD2	114784	broad.mit.edu	37	1	34286094	34286094	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:34286094C>T	uc001bxn.1	-	8	1084	c.1055G>A	c.(1054-1056)GGC>GAC	p.G352D	CSMD2_uc001bxm.1_Missense_Mutation_p.G392D	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	352	Extracellular (Potential).|Sushi 2.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TAGTCTTTTGCCCCTTTCGGG	0.463			NA											5	352					0	0	0.001168	0	0
RLF	6018	broad.mit.edu	37	1	40701712	40701712	+	Silent	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:40701712G>A	uc001cfc.3	+	8	1369	c.1338G>A	c.(1336-1338)CCG>CCA	p.P446P	RLF_uc001cfd.3_Silent_p.P137P	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	446					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			AAAATGCACCGGTTCCAAATT	0.373			NA											4	165					0	0	0.009096	0	0
ELTD1	64123	broad.mit.edu	37	1	79357333	79357333	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:79357333G>A	uc001diq.3	-	14	2042	c.1886C>T	c.(1885-1887)ACC>ATC	p.T629I		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	629	Helical; Name=6; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		GATCCAGGTGGTGCCGAGAAG	0.463			NA											7	33					0	0	0.006214	0	0
DNTTIP2	30836	broad.mit.edu	37	1	94342195	94342195	+	Silent	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:94342195G>A	uc001dqf.2	-	2	1334	c.1296C>T	c.(1294-1296)AAC>AAT	p.N432N	DNTTIP2_uc010otm.1_RNA|DNTTIP2_uc009wdo.1_Silent_p.N227N	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,	432					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		CCTGAGATGTGTTGGGCGCAG	0.388			NA											56	226					0	0	0.01441	0	0
COL11A1	1301	broad.mit.edu	37	1	103352528	103352528	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:103352528C>A	uc001dul.2	-	63	5011	c.4693G>T	c.(4693-4695)GCA>TCA	p.A1565S	COL11A1_uc001duk.2_Missense_Mutation_p.A761S|COL11A1_uc001dum.2_Missense_Mutation_p.A1577S|COL11A1_uc001dun.2_Missense_Mutation_p.A1526S|COL11A1_uc009weh.2_Missense_Mutation_p.A1449S	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1565					collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTATCATCTGCATCTGCTTGC	0.393			NA											16	92					1.5739e-10	2.05646e-10	0.004007	1	0
NTRK1	4914	broad.mit.edu	37	1	156849038	156849038	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:156849038C>A	uc001fqh.1	+	15	1986	c.1930C>A	c.(1930-1932)CTG>ATG	p.L644M	NTRK1_uc001fqf.1_Missense_Mutation_p.L608M|NTRK1_uc009wsi.1_Missense_Mutation_p.L343M|NTRK1_uc001fqi.1_Missense_Mutation_p.L638M|NTRK1_uc009wsk.1_Missense_Mutation_p.L641M	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	644	Cytoplasmic (Potential).|Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	CCTGGCGGGTCTGCATTTTGT	0.632			NA	T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			13	38					0.00136819	0.00146328	0.013537	1	0
CD1A	909	broad.mit.edu	37	1	158226831	158226831	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:158226831G>T	uc001frt.2	+	4	1393	c.860G>T	c.(859-861)GGC>GTC	p.G287V		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	287	Extracellular (Potential).|Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	AGTCTAGAGGGCCAGGACATC	0.592			NA											32	72					2.49991e-28	4.19683e-28	0.003271	1	0
SEC16B	89866	broad.mit.edu	37	1	177911130	177911130	+	Missense_Mutation	SNP	C	C	T	rs139593986	by1000genomes	TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:177911130C>T	uc001gli.1	-	16	2017	c.1927G>A	c.(1927-1929)GTG>ATG	p.V643M	SEC16B_uc001glk.1_Missense_Mutation_p.V320M|SEC16B_uc009wwy.1_Missense_Mutation_p.V198M|SEC16B_uc001glh.1_Missense_Mutation_p.V302M|SEC16B_uc009wwz.1_Missense_Mutation_p.V302M|SEC16B_uc001glj.1_Missense_Mutation_p.V644M	NM_033127	NP_149118	Q96JE7	SC16B_HUMAN	leucine zipper transcription regulator 2	643					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				ovary(3)|central_nervous_system(1)	4						GCCTGGGACACGAGGCCATAA	0.512			NA											23	44					0	0	0.00278	0	0
TOR1AIP2	163590	broad.mit.edu	37	1	179820234	179820234	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:179820234C>A	uc001gnk.2	-	4	687	c.299G>T	c.(298-300)GGG>GTG	p.G100V	TOR1AIP2_uc001gnl.2_Missense_Mutation_p.G100V	NM_145034	NP_659471	Q8NFQ8	TOIP2_HUMAN	torsin A interacting protein 2	100						endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1						GAGGTGATGCCCTTTTCCGCC	0.458			NA											43	105					4.16155e-14	5.85151e-14	0.00874	1	0
CACNA1E	777	broad.mit.edu	37	1	181745281	181745281	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:181745281C>A	uc001gow.2	+	38	5349	c.5184C>A	c.(5182-5184)TAC>TAA	p.Y1728*	CACNA1E_uc009wxs.2_Nonsense_Mutation_p.Y1616*|CACNA1E_uc001gox.1_Nonsense_Mutation_p.Y954*|CACNA1E_uc009wxt.2_Nonsense_Mutation_p.Y954*	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1728	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						ACTTTGAGTACCTGACTCGGG	0.567			NA											40	252					9.9191e-30	1.68564e-29	0.00874	1	0
CRB1	23418	broad.mit.edu	37	1	197390454	197390454	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:197390454G>T	uc001gtz.2	+	6	1631	c.1496G>T	c.(1495-1497)GGC>GTC	p.G499V	CRB1_uc010poz.1_Missense_Mutation_p.G430V|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.G387V|CRB1_uc010ppb.1_Missense_Mutation_p.G499V|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_5'UTR|CRB1_uc001gub.1_Missense_Mutation_p.G148V	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	499	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						GTCAAAAGTGGCTCAGTGACA	0.502			NA											32	54					8.4185e-14	1.17774e-13	0.012213	1	0
TMEM9	252839	broad.mit.edu	37	1	201120964	201120964	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:201120964C>T	uc001gvw.2	-	3	405	c.83G>A	c.(82-84)CGG>CAG	p.R28Q	TMEM9_uc001gvx.2_Missense_Mutation_p.R28Q|TMEM9_uc001gvy.2_Missense_Mutation_p.R28Q|TMEM9_uc010ppo.1_Missense_Mutation_p.R53Q|TMEM9_uc001gvz.2_Missense_Mutation_p.R31Q|TMEM9_uc001gwa.2_Missense_Mutation_p.R28Q|TMEM9_uc010ppp.1_Missense_Mutation_p.R28Q	NM_016456	NP_057540	Q9P0T7	TMEM9_HUMAN	transmembrane protein 9 precursor	28	Extracellular (Potential).				transport	integral to membrane|late endosome membrane|lysosomal membrane					0		Breast(1374;0.000301)				GCATTTGCACCGGATATCTTC	0.488			NA											13	212					0	0	0.004007	0	0
PLEKHA6	22874	broad.mit.edu	37	1	204237400	204237400	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:204237400C>T	uc001hau.2	-	4	460	c.143G>A	c.(142-144)CGC>CAC	p.R48H		NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	48										ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GGAGTGTGAGCGCTTGCCAAA	0.612			NA											25	57					0	0	0.004656	0	0
C1orf95	375057	broad.mit.edu	37	1	226784558	226784558	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:226784558C>G	uc010pvn.1	+	2	363	c.258C>G	c.(256-258)GAC>GAG	p.D86E		NM_001003665	NP_001003665	Q69YW2	CA095_HUMAN	hypothetical protein LOC375057	86						integral to membrane				ovary(1)	1	Breast(184;0.133)	Prostate(94;0.0885)		GBM - Glioblastoma multiforme(131;0.113)		ACCTCCCGGACAGGCATGTGT	0.612			NA											6	242					0	0	0.004482	0	0
OBSCN	84033	broad.mit.edu	37	1	228565299	228565299	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:228565299A>G	uc009xez.1	+	102	23433	c.23389A>G	c.(23389-23391)ATG>GTG	p.M7797V	OBSCN_uc001hsr.1_Missense_Mutation_p.M2426V	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	7797	Protein kinase 2.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GTCCGAGAACATGATCATCAC	0.552			NA											13	62					0	0	0.013537	0	0
TRIM67	440730	broad.mit.edu	37	1	231349585	231349585	+	Silent	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:231349585G>A	uc009xfn.1	+	9	2190	c.2148G>A	c.(2146-2148)GGG>GGA	p.G716G		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	tripartite motif-containing 67	716	B30.2/SPRY.					cytoplasm|cytoskeleton	zinc ion binding			ovary(2)|breast(1)|kidney(1)	4	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				TGTGCAAGGGGGCCACCGTGG	0.592			NA											24	158					0	0	0.010818	0	0
PCNXL2	80003	broad.mit.edu	37	1	233344406	233344406	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:233344406T>A	uc001hvl.2	-	13	2956	c.2721A>T	c.(2719-2721)AGA>AGT	p.R907S	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc001hvp.1_RNA|PCNXL2_uc009xfv.1_RNA|PCNXL2_uc001hvq.1_Missense_Mutation_p.R206S	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	907	Helical; (Potential).					integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				AATAGATTGGTCTGCTATATG	0.398			NA											12	65					0	0	0.003163	0	0
RYR2	6262	broad.mit.edu	37	1	237813354	237813354	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:237813354G>T	uc001hyl.1	+	50	7810	c.7690G>T	c.(7690-7692)GCT>TCT	p.A2564S		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2564	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACTTACCAAAGCTCAGCGGGA	0.403			NA											56	171					3.00063e-23	4.88926e-23	0.01441	1	0
FMN2	56776	broad.mit.edu	37	1	240371509	240371509	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:240371509C>A	uc010pyd.1	+	5	3622	c.3397C>A	c.(3397-3399)CCC>ACC	p.P1133T	FMN2_uc010pye.1_Missense_Mutation_p.P1137T	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1133	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			ACCCCCTCCTCCCCCTCTTCC	0.716			NA											6	15					5.18039e-06	6.00405e-06	0.00308	1	0
C10orf18	54906	broad.mit.edu	37	10	5777379	5777379	+	Silent	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr10:5777379G>A	uc001iij.2	+	12	1942	c.1317G>A	c.(1315-1317)AGG>AGA	p.R439R	C10orf18_uc001iik.2_Intron	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	439										ovary(1)|central_nervous_system(1)	2						AAAGGGCAAGGAAACAAGAGA	0.388			NA											5	214					0	0	0.000602	0	0
C10orf53	282966	broad.mit.edu	37	10	50916423	50916423	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr10:50916423T>A	uc001jid.1	+	3	294	c.234T>A	c.(232-234)AGT>AGA	p.S78R		NM_182554	NP_872360	Q8N6V4	CJ053_HUMAN	chromosome 10 open reading frame 53 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0		all_neural(218;0.107)				tcaccccaagtagtgacaaga	0			NA											31	83					0	0	0.010818	0	0
UNC5B	219699	broad.mit.edu	37	10	73056384	73056384	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr10:73056384G>C	uc001jro.2	+	15	2820	c.2375G>C	c.(2374-2376)TGC>TCC	p.C792S	UNC5B_uc001jrp.2_Missense_Mutation_p.C781S	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	792	Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						GCCCTCCACTGCACTTTCACC	0.612			NA											3	34					0	0	0.001168	0	0
TNKS2	80351	broad.mit.edu	37	10	93576936	93576936	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr10:93576936G>T	uc001khp.2	+	3	767	c.470G>T	c.(469-471)GGA>GTA	p.G157V		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	157					positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				AATACAGATGGAAGGACAGCA	0.408			NA											6	14					2.0095e-06	2.35861e-06	0.001984	1	0
NLRP14	338323	broad.mit.edu	37	11	7059986	7059986	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr11:7059986G>T	uc001mfb.1	+	2	492	c.169G>T	c.(169-171)GAC>TAC	p.D57Y		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	57	DAPIN.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		CAGGCGGGAGGACCTGGCCAA	0.453			NA											13	78					0.000219431	0.000242161	0.00245	1	0
USH1C	10083	broad.mit.edu	37	11	17552759	17552759	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr11:17552759C>A	uc001mnf.2	-	4	438	c.329G>T	c.(328-330)TGT>TTT	p.C110F	USH1C_uc001mne.2_Missense_Mutation_p.C110F|USH1C_uc009yhb.2_Missense_Mutation_p.C110F|USH1C_uc001mng.2_RNA|USH1C_uc001mnd.2_Missense_Mutation_p.C74F	NM_005709	NP_005700	Q9Y6N9	USH1C_HUMAN	harmonin isoform a	110	PDZ 1.				equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1						GAAGAGCCCACAGCCAAACTC	0.657			NA											18	81					0.000175454	0.000194403	0.010504	1	0
TSG101	7251	broad.mit.edu	37	11	18503191	18503192	+	Missense_Mutation	DNP	CC	CC	AG			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr11:18503191_18503192CC>AG	uc001mor.2	-	9	1194_1195	c.1068_1069GG>CT	c.(1066-1071)CTGGAT>CTCTAT	p.D357Y		NM_006292	NP_006283	Q99816	TS101_HUMAN	tumor susceptibility gene 101	357	SB.				cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	calcium-dependent protein binding|DNA binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding				0						AGGAAGACATCCAGGTCTATCA	0.406	GBM(99;1348 1396 8611 26475 50572)		NA											25	76					0	0	0.004672	0	0
NAV2	89797	broad.mit.edu	37	11	19890506	19890506	+	Silent	SNP	A	A	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr11:19890506A>T	uc010rdm.1	+	4	835	c.474A>T	c.(472-474)GCA>GCT	p.A158A	NAV2_uc001mpp.2_Silent_p.A94A|NAV2_uc001mpr.3_Silent_p.A158A	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	158	CH.					nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						ATTTCCTGGCAGCTAAGGGAA	0.433			NA											16	42					0	0	0.014323	0	0
KCNA4	3739	broad.mit.edu	37	11	30033103	30033104	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr11:30033103_30033104CC>AA	uc001msk.2	-	2	2274_2275	c.1122_1123GG>TT	c.(1120-1125)GTGGAA>GTTTAA	p.E375*		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	375	Helical; Name=Segment S2; (Potential).					voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CAGACTGTTTCCACGATGAAGA	0.46			NA											35	113					0	0	0.004672	0	0
RAG2	5897	broad.mit.edu	37	11	36614627	36614627	+	Missense_Mutation	SNP	G	G	T	rs150349031	byFrequency	TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr11:36614627G>T	uc001mwv.3	-	2	1280	c.1092C>A	c.(1090-1092)AAC>AAA	p.N364K	RAG1_uc001mwt.2_RNA|C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	364					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				ATGTTTGACTGTTTGTGAATG	0.368			NA							Familial_Hemophagocytic_Lymphohistiocytosis				45	157					1.22674e-20	1.94176e-20	0.00874	1	0
PTPRJ	5795	broad.mit.edu	37	11	48146645	48146645	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr11:48146645G>T	uc001ngp.3	+	6	1355	c.1000G>T	c.(1000-1002)GGG>TGG	p.G334W	PTPRJ_uc001ngo.3_Missense_Mutation_p.G334W	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	334	Extracellular (Potential).|Fibronectin type-III 3.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						CCTGCTTGTCGGGTTAGAGCC	0.607			NA											50	180					7.06795e-37	1.24702e-36	0.01441	1	0
OR5D16	390144	broad.mit.edu	37	11	55607017	55607017	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr11:55607017C>A	uc010rio.1	+	1	790	c.790C>A	c.(790-792)CCC>ACC	p.P264T		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				CTACTGTGTACCCAACTCCAA	0.522			NA											18	84					0.000295444	0.000322196	0.014323	1	0
OR5B3	441608	broad.mit.edu	37	11	58170034	58170034	+	Silent	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr11:58170034C>A	uc010rkf.1	-	1	849	c.849G>T	c.(847-849)CTG>CTT	p.L283L		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	283	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CCAGAGGGTTCAGCATGGGGA	0.428			NA											12	81					3.01185e-09	3.72447e-09	0.003954	1	0
OR4D6	219983	broad.mit.edu	37	11	59225059	59225059	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr11:59225059T>A	uc010rku.1	+	1	626	c.626T>A	c.(625-627)CTC>CAC	p.L209H		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GTGACCCTGCTCTGGTTCCTC	0.557			NA											38	149					0	0	0.00623	0	0
SCGB2A2	4250	broad.mit.edu	37	11	62037700	62037700	+	Silent	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr11:62037700G>T	uc001ntc.2	+	1	71	c.12G>T	c.(10-12)CTG>CTT	p.L4L	SCGB2A2_uc009ynx.2_Silent_p.L4L	NM_002411	NP_002402	Q13296	SG2A2_HUMAN	secretoglobin, family 2A, member 2 precursor	4						extracellular region	steroid binding			ovary(1)	1						TGAAGTTGCTGATGGTCCTCA	0.602			NA											46	214					2.12129e-23	3.4769e-23	0.01441	1	0
EML3	256364	broad.mit.edu	37	11	62373360	62373360	+	Silent	SNP	T	T	C			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr11:62373360T>C	uc001ntu.1	-	14	2057	c.1749A>G	c.(1747-1749)GGA>GGG	p.G583G	EML3_uc001ntr.1_Silent_p.G555G|EML3_uc001nts.1_Silent_p.G555G|EML3_uc001ntt.1_Silent_p.G467G|EML3_uc010rly.1_Silent_p.G583G	NM_153265	NP_694997	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like	583						cytoplasm|microtubule	protein binding			ovary(1)	1						GGGCCAGGTCTCCCCTCAGCA	0.612			NA											34	118					0	0	0.004289	0	0
NOX4	50507	broad.mit.edu	37	11	89088203	89088203	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr11:89088203G>A	uc001pct.2	-	13	1383	c.1144C>T	c.(1144-1146)CGA>TGA	p.R382*	NOX4_uc009yvr.2_Nonsense_Mutation_p.R357*|NOX4_uc001pcu.2_Nonsense_Mutation_p.R308*|NOX4_uc001pcw.2_Nonsense_Mutation_p.R75*|NOX4_uc001pcx.2_Nonsense_Mutation_p.R75*|NOX4_uc001pcv.2_Nonsense_Mutation_p.R382*|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Nonsense_Mutation_p.R216*|NOX4_uc009yvp.2_Intron|NOX4_uc010rtv.1_Nonsense_Mutation_p.R358*|NOX4_uc009yvq.2_Nonsense_Mutation_p.R358*	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	382	FAD-binding FR-type.|Extracellular (Potential).|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				AGTAAATCTCGAAATCGTTCT	0.328			NA											7	42					0	0	0.001984	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103029646	103029646	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr11:103029646G>A	uc001pho.2	+	28	4412	c.4268G>A	c.(4267-4269)CGC>CAC	p.R1423H	DYNC2H1_uc001phn.1_Missense_Mutation_p.R1423H|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	1423	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TAGGAAAAACGCTCAGCATTC	0.274			NA											3	16					0	0	0.004672	0	0
WNT5B	81029	broad.mit.edu	37	12	1741938	1741938	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr12:1741938C>A	uc009zdq.2	+	3	437	c.195C>A	c.(193-195)TAC>TAA	p.Y65*	WNT5B_uc001qjj.2_Nonsense_Mutation_p.Y65*|WNT5B_uc001qjk.2_Nonsense_Mutation_p.Y65*|WNT5B_uc001qjl.2_Nonsense_Mutation_p.Y65*	NM_032642	NP_116031	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family,	65					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			GCCAATTGTACCAGGAGCACA	0.612			NA											40	140					1.49673e-21	2.42453e-21	0.00623	1	0
A2ML1	144568	broad.mit.edu	37	12	8976459	8976459	+	Silent	SNP	C	C	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr12:8976459C>G	uc001quz.3	+	3	488	c.390C>G	c.(388-390)CTC>CTG	p.L130L		NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	Error:Variant_position_missing_in_B3KVV6_after_alignment						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						ACAAACCTCTCTACACCCCAG	0.493			NA											13	76					0	0	0.001855	0	0
ABCC9	10060	broad.mit.edu	37	12	22012531	22012531	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr12:22012531T>C	uc001rfi.1	-	20	2514	c.2494A>G	c.(2494-2496)ATT>GTT	p.I832V	ABCC9_uc001rfh.2_Missense_Mutation_p.I832V|ABCC9_uc001rfj.1_Missense_Mutation_p.I796V	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	832	Cytoplasmic (Potential).|ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AAAAAGACAATGTTGGTGTTT	0.423			NA											38	120					0	0	0.00623	0	0
SOX5	6660	broad.mit.edu	37	12	23818455	23818455	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr12:23818455G>A	uc001rfw.2	-	7	956	c.854C>T	c.(853-855)CCT>CTT	p.P285L	SOX5_uc001rfx.2_Missense_Mutation_p.P272L|SOX5_uc001rfy.2_Missense_Mutation_p.P272L|SOX5_uc010siv.1_Missense_Mutation_p.P272L|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.P237L	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	285					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						CCGTTGATCAGGAGGGAATAC	0.488			NA											28	87					0	0	0.013726	0	0
FGD4	121512	broad.mit.edu	37	12	32735088	32735088	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr12:32735088C>G	uc001rkz.2	+	4	764	c.287C>G	c.(286-288)GCA>GGA	p.A96G	FGD4_uc001rlc.2_Missense_Mutation_p.A181G|FGD4_uc001rky.2_5'UTR|FGD4_uc001rla.2_5'UTR|FGD4_uc010ske.1_Missense_Mutation_p.A208G|FGD4_uc001rlb.1_RNA|FGD4_uc001rkx.3_Missense_Mutation_p.A96G	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	96	Actin filament-binding (By similarity).				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					GTAATGGCAGCACAAAACCAG	0.473			NA											5	66					0	0	0.006214	0	0
METTL7A	25840	broad.mit.edu	37	12	51319018	51319018	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr12:51319018C>T	uc001rxb.2	+	1	485	c.197C>T	c.(196-198)GCG>GTG	p.A66V	METTL7A_uc010smv.1_Missense_Mutation_p.A66V	NM_014033	NP_054752	Q9H8H3	MET7A_HUMAN	methyltransferase like 7A precursor	66						endoplasmic reticulum|lipid particle|membrane	methyltransferase activity				0						CAGGAGTTTGCGGGCCCCTCC	0.552			NA											4	77					0	0	0.009096	0	0
KRT79	338785	broad.mit.edu	37	12	53215788	53215788	+	Silent	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr12:53215788C>A	uc001sbb.2	-	9	1509	c.1476G>T	c.(1474-1476)GGG>GGT	p.G492G	KRT79_uc001sba.2_Silent_p.G263G	NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	492	Tail.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						CCCCCCCACTCCCACCCAGGG	0.612			NA											17	58					3.41278e-10	4.39693e-10	0.00499	1	0
RARG	5916	broad.mit.edu	37	12	53607014	53607014	+	Silent	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr12:53607014C>T	uc001sce.2	-	9	1517	c.1032G>A	c.(1030-1032)CTG>CTA	p.L344L	RARG_uc001scd.2_Silent_p.L333L|RARG_uc010sob.1_Silent_p.L322L|RARG_uc001scf.2_Silent_p.L344L|RARG_uc001scg.2_Silent_p.L272L|RARG_uc010soc.1_Silent_p.L223L	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	344	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	CGGGCTCCTCCAGGTCCATGC	0.597			NA									OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	56					0	0	0.008291	0	0
NTS	4922	broad.mit.edu	37	12	86268247	86268247	+	Silent	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr12:86268247G>T	uc001tag.2	+	1	173	c.66G>T	c.(64-66)CTG>CTT	p.L22L		NM_006183	NP_006174	P30990	NEUT_HUMAN	neurotensin/neuromedin N preproprotein	22					regulation of blood vessel size|signal transduction	extracellular region|soluble fraction|transport vesicle	neuropeptide hormone activity				0						CCTGGAGTCTGTGCTCAGGTA	0.423			NA											15	50					2.32078e-09	2.89575e-09	0.003163	1	0
MED13L	23389	broad.mit.edu	37	12	116413011	116413011	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr12:116413011C>A	uc001tvw.2	-	25	5751	c.5696G>T	c.(5695-5697)GGG>GTG	p.G1899V		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1899					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CCCAAGTCGCCCGATTACAAC	0.443			NA											16	58					0.000308642	0.00033527	0.003163	1	0
TAOK3	51347	broad.mit.edu	37	12	118650764	118650764	+	Missense_Mutation	SNP	C	C	A	rs147202627	byFrequency	TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr12:118650764C>A	uc001twx.2	-	11	1069	c.774G>T	c.(772-774)TTG>TTT	p.L258F	TAOK3_uc001tww.2_Missense_Mutation_p.L88F|TAOK3_uc001twy.3_Missense_Mutation_p.L258F	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	258	Protein kinase.				MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTATTTTCTGCAAGCAGTAAT	0.358			NA											8	28					2.27111e-07	2.71163e-07	0.013537	1	0
N4BP2L2	10443	broad.mit.edu	37	13	33092138	33092138	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr13:33092138C>G	uc001uuk.3	-	6	1731	c.1553G>C	c.(1552-1554)AGG>ACG	p.R518T	N4BP2L2_uc001uuj.2_Missense_Mutation_p.R34T|N4BP2L2_uc010abe.1_Missense_Mutation_p.R89T|N4BP2L2_uc010tdz.1_Missense_Mutation_p.R74T	NM_014887	NP_055702	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	518											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		ATGTTTATTCCTCCTAACAAA	0.318			NA											13	35					0	0	0.00245	0	0
DACH1	1602	broad.mit.edu	37	13	72440283	72440283	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr13:72440283C>T	uc010thn.1	-	2	1042	c.619G>A	c.(619-621)GAG>AAG	p.E207K	DACH1_uc010tho.1_Missense_Mutation_p.E207K|DACH1_uc010thp.1_Missense_Mutation_p.E207K	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	207	Interaction with SIX6 and HDAC3 (By similarity).|DACHbox-N.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		CAGATCAGCTCGCAGCCCTCC	0.587			NA											20	56					0	0	0.00278	0	0
UGGT2	55757	broad.mit.edu	37	13	96515938	96515938	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr13:96515938C>A	uc001vmt.2	-	31	3759	c.3589G>T	c.(3589-3591)GAT>TAT	p.D1197Y		NM_020121	NP_064506	Q9NYU1	UGGG2_HUMAN	UDP-glucose ceramide glucosyltransferase-like 2	1197					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3						GTAAGGATATCTTCCTTAATT	0.308			NA											9	73					0.00621372	0.00656946	0.006214	1	0
FGF14	2259	broad.mit.edu	37	13	102375188	102375188	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr13:102375188G>T	uc001vpe.2	-	5	737	c.737C>A	c.(736-738)ACA>AAA	p.T246K	FGF14_uc001vpf.2_Missense_Mutation_p.T251K|FGF14_uc001vpd.1_5'Flank	NM_004115	NP_004106	Q92915	FGF14_HUMAN	fibroblast growth factor 14 isoform 1A	246					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			ovary(2)|lung(1)|large_intestine(1)	4	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGGCTATGTTGTCTTACTCTT	0.498			NA											18	47					1.00905e-13	1.40455e-13	0.008871	1	0
OR4N2	390429	broad.mit.edu	37	14	20296431	20296431	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr14:20296431A>T	uc010tkv.1	+	1	824	c.824A>T	c.(823-825)CAC>CTC	p.H275L		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	275	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCTCTCTTCCACACAGTGATT	0.433			NA											19	144					0	0	0.007413	0	0
OR4K15	81127	broad.mit.edu	37	14	20443788	20443788	+	Silent	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr14:20443788G>T	uc010tkx.1	+	1	111	c.111G>T	c.(109-111)GTG>GTT	p.V37V		NM_001005486	NP_001005486	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K,	37	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CAGAATTTGTGTTGCTGGGAC	0.398			NA											40	155					1.8453e-21	2.97179e-21	0.010771	1	0
C14orf28	122525	broad.mit.edu	37	14	45373686	45373686	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr14:45373686G>A	uc001wvo.2	+	4	969	c.703G>A	c.(703-705)GAA>AAA	p.E235K	C14orf28_uc001wvp.1_Missense_Mutation_p.E235K	NM_001017923	NP_001017923	Q4W4Y0	CN028_HUMAN	hypothetical protein LOC122525	235										ovary(1)	1						TTGGAAATCTGAAGATCTGGC	0.348			NA											6	101					0	0	0.001168	0	0
PTGDR	5729	broad.mit.edu	37	14	52735015	52735015	+	Silent	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr14:52735015G>T	uc001wzq.2	+	1	585	c.483G>T	c.(481-483)CTG>CTT	p.L161L		NM_000953	NP_000944	Q13258	PD2R_HUMAN	prostaglandin D2 receptor	161	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	CCTTCTCCCTGGCTTTCTGCG	0.637			NA											43	152					2.24893e-16	3.29605e-16	0.009718	1	0
ADAM21P1	145241	broad.mit.edu	37	14	70712902	70712902	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr14:70712902G>T	uc010ttg.1	-	1	1617	c.966C>A	c.(964-966)GAC>GAA	p.D322E		NR_003951				SubName: Full=ADAM21-like protein;												0						AGGGGATCCCGTCCTGCACAT	0.448			NA											14	51					1.5739e-10	2.05646e-10	0.004007	1	0
CATSPERB	79820	broad.mit.edu	37	14	92074715	92074715	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr14:92074715C>A	uc001xzs.1	-	22	2772	c.2632G>T	c.(2632-2634)GCT>TCT	p.A878S	CATSPERB_uc010aub.1_Missense_Mutation_p.A400S	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	878					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				AGTGGAATAGCAATTCCCATA	0.299			NA											10	50					2.80697e-09	3.48669e-09	0.010729	1	0
UBR7	55148	broad.mit.edu	37	14	93686679	93686679	+	Nonsense_Mutation	SNP	C	C	T	rs147191980		TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr14:93686679C>T	uc001ybm.3	+	9	1281	c.1045C>T	c.(1045-1047)CAG>TAG	p.Q349*	UBR7_uc001ybn.3_Nonsense_Mutation_p.Q273*|UBR7_uc010auq.2_Nonsense_Mutation_p.Q198*	NM_175748	NP_786924	Q8N806	UBR7_HUMAN	ubiquitin protein ligase E3 component n-recognin	349							ubiquitin-protein ligase activity|zinc ion binding				0						GAAGATTGCCCAGGCCACTGA	0.418			NA											32	138					0	0	0.004289	0	0
OR4N3P	390539	broad.mit.edu	37	15	22413749	22413749	+	Silent	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr15:22413749C>A	uc001yuf.2	+	1	48	c.48C>A	c.(46-48)GGC>GGA	p.G16G		NM_001080841	NP_001074310			RecName: Full=Olfactory receptor 4N2; AltName: Full=Olfactory receptor OR14-8; AltName: Full=Olfactory receptor OR14-13;												0						CCTACAGAGGCTGCATCACTC	0.517			NA											30	289					3.03874e-20	4.72882e-20	0.003271	1	0
C15orf2	23742	broad.mit.edu	37	15	24921511	24921511	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr15:24921511C>A	uc001ywo.2	+	1	971	c.497C>A	c.(496-498)CCG>CAG	p.P166Q		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	166					cell differentiation|multicellular organismal development|spermatogenesis			p.P166P(1)		ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GATGAGGATCCGGTGCAGATC	0.632			NA											18	68					9.16793e-09	1.11873e-08	0.00499	1	0
GABRA5	2558	broad.mit.edu	37	15	27128544	27128544	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr15:27128544G>T	uc001zbd.1	+	7	676	c.337G>T	c.(337-339)GGG>TGG	p.G113W	GABRB3_uc001zbb.2_Intron	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	113	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCGGTTTAAGGGGCCCATGCA	0.542			NA											36	84					1.57019e-19	2.403e-19	0.007835	1	0
GABRG3	2567	broad.mit.edu	37	15	27765182	27765182	+	Silent	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr15:27765182G>A	uc001zbg.1	+	7	943	c.777G>A	c.(775-777)CAG>CAA	p.Q259Q		NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	259	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		TCACCATTCAGACATACATTC	0.343	NSCLC(114;800 1656 7410 37729 45293)		NA											3	8					0	0	0.009096	0	0
HERC2	8924	broad.mit.edu	37	15	28459224	28459224	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr15:28459224C>A	uc001zbj.2	-	41	6659	c.6553G>T	c.(6553-6555)GGG>TGG	p.G2185W		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2185					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AAACCCACCCCTTCGGAAGGC	0.537			NA											28	71					1.80694e-10	2.34988e-10	0.009535	1	0
MGA	23269	broad.mit.edu	37	15	42042148	42042148	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr15:42042148G>T	uc010ucy.1	+	17	6524	c.6343G>T	c.(6343-6345)GAA>TAA	p.E2115*	MGA_uc010ucz.1_Nonsense_Mutation_p.E1906*|MGA_uc010uda.1_Nonsense_Mutation_p.E731*|MGA_uc001zoi.2_Nonsense_Mutation_p.E329*	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2076	Basic motif.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TGTGAAGGTGGAACAGCAGAA	0.363			NA											8	31					2.74318e-10	3.55075e-10	0.006214	1	0
ATP8B4	79895	broad.mit.edu	37	15	50264909	50264909	+	Silent	SNP	A	A	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr15:50264909A>T	uc001zxu.2	-	13	1255	c.1113T>A	c.(1111-1113)CCT>CCA	p.P371P	ATP8B4_uc010ber.2_Silent_p.P244P|ATP8B4_uc010ufd.1_Silent_p.P244P|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	371	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		GAGCCACTGCAGGTATTGCTT	0.418			NA											9	30					0	0	0.004007	0	0
CCDC33	80125	broad.mit.edu	37	15	74559018	74559018	+	Splice_Site	SNP	G	G	C			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr15:74559018G>C	uc002axo.2	+	4	714	c.320_splice	c.e4-1	p.D107_splice	CCDC33_uc002axp.2_5'Flank	NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1								protein binding			ovary(3)|skin(2)	5						TCTCTTTCCAGATGTGATCCT	0.448			NA											38	177					0	0	0.00874	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79088964	79088964	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr15:79088964C>A	uc002bej.3	-	4	998	c.787G>T	c.(787-789)GTT>TTT	p.V263F	ADAMTS7_uc010und.1_Missense_Mutation_p.V263F|ADAMTS7_uc002bek.1_Missense_Mutation_p.V263F	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	263	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						TAGCTCTCAACCTGCGGCTGT	0.562			NA											47	193					9.59835e-30	1.6412e-29	0.01441	1	0
ZNF592	9640	broad.mit.edu	37	15	85327613	85327613	+	Silent	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr15:85327613G>A	uc002bld.2	+	4	2043	c.1707G>A	c.(1705-1707)GCG>GCA	p.A569A	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	569					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CCCTCTATGCGCCAAATCTCA	0.597			NA											27	126					0	0	0.00632	0	0
AGBL1	123624	broad.mit.edu	37	15	87217502	87217502	+	Splice_Site	SNP	A	A	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr15:87217502A>G	uc002blz.1	+	22	3000	c.2920_splice	c.e22-2	p.G974_splice		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1						C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						TTTAACTGGCAGGGTCTACAG	0.478			NA											6	15					0	0	0.001984	0	0
FES	2242	broad.mit.edu	37	15	91434895	91434895	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr15:91434895G>A	uc002bpv.2	+	12	1738	c.1642G>A	c.(1642-1644)GCT>ACT	p.A548T	FES_uc010uqj.1_Missense_Mutation_p.A420T|FES_uc010uqk.1_Missense_Mutation_p.A530T|FES_uc002bpw.2_RNA|FES_uc010bny.2_Missense_Mutation_p.A420T|FES_uc002bpx.2_Missense_Mutation_p.A478T|FES_uc002bpy.2_Missense_Mutation_p.A490T	NM_002005	NP_001996	P07332	FES_HUMAN	feline sarcoma oncogene isoform 1	548	SH2.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			CCTGCACAGGGCTGTGCCCAA	0.622			NA											4	111					0	0	0.009096	0	0
LRRK1	79705	broad.mit.edu	37	15	101601410	101601410	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr15:101601410A>T	uc002bwr.2	+	30	5033	c.4714A>T	c.(4714-4716)ATG>TTG	p.M1572L	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bws.2_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1572					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GAAGGGCCTCATGGAGGTGCA	0.617			NA											12	48					0	0	0.013537	0	0
Unknown	0	broad.mit.edu	37	15	102292829	102292829	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr15:102292829C>G	uc010usj.1	+	4	476	c.417C>G	c.(415-417)CAC>CAG	p.H139Q	uc002bxo.2_5'Flank|uc002bxp.3_5'Flank|uc002bxt.2_5'Flank|uc002bxz.3_5'Flank|uc002byd.2_5'Flank|uc002bye.2_5'Flank|uc002byf.1_5'Flank|uc002byg.2_5'Flank|uc002byi.2_5'Flank|uc002byk.2_5'Flank|uc002bym.2_5'Flank|uc002byn.2_5'Flank|uc010usm.1_5'Flank|uc002byr.2_5'Flank					RecName: Full=Uncharacterized protein C15orf51.; Flags: Fragment;												NA						CGAGAAGACACTCGTGGAGGC	0.597			NA											2	7					0	0	0.004672	0	0
NARFL	64428	broad.mit.edu	37	16	781625	781625	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr16:781625C>A	uc002cjr.2	-	9	986	c.974G>T	c.(973-975)CGG>CTG	p.R325L	NARFL_uc002cjp.2_Missense_Mutation_p.R223L|NARFL_uc002cjq.2_Missense_Mutation_p.R223L|NARFL_uc002cjs.2_Missense_Mutation_p.R107L|NARFL_uc010uuq.1_Missense_Mutation_p.G134C	NM_022493	NP_071938	Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	325					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding				0		Hepatocellular(780;0.0218)				GGCCGCGTGCCGGAACACGTG	0.662			NA											3	3					0.004672	0.00495841	0.004672	1	0
ZP2	7783	broad.mit.edu	37	16	21213575	21213575	+	Silent	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr16:21213575G>A	uc002dii.2	-	11	1137	c.1137C>T	c.(1135-1137)GAC>GAT	p.D379D	ZP2_uc010bwn.1_Silent_p.D418D	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	379	Extracellular (Potential).|ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)		AGACCTCGACGTCCATAAACC	0.512			NA											4	40					0	0	0.000602	0	0
ZNF423	23090	broad.mit.edu	37	16	49671380	49671380	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr16:49671380C>G	uc002efs.2	-	5	1981	c.1683G>C	c.(1681-1683)GAG>GAC	p.E561D	ZNF423_uc010vgn.1_Missense_Mutation_p.E444D	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	561					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				AGGAATAGACCTCCATGAAGG	0.577			NA											29	95					0	0	0.012213	0	0
CDH8	1006	broad.mit.edu	37	16	61761098	61761098	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr16:61761098C>A	uc002eog.1	-	9	1688	c.1436G>T	c.(1435-1437)CGA>CTA	p.R479L	CDH8_uc002eoh.2_Missense_Mutation_p.R248L	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	479	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		AACAGGTACTCGTGATATCTG	0.408			NA											29	124					5.91797e-21	9.47559e-21	0.012213	1	0
HAS3	3038	broad.mit.edu	37	16	69148656	69148656	+	Silent	SNP	A	A	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr16:69148656A>T	uc010cfh.2	+	4	1373	c.1149A>T	c.(1147-1149)TCA>TCT	p.S383S	HAS3_uc002ewk.2_Intron|HAS3_uc002ewl.2_Silent_p.S383S	NM_005329	NP_005320	O00219	HAS3_HUMAN	hyaluronan synthase 3 isoform a	383	Helical; Name=3; (Potential).				carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)		CCTACGAGTCAGTGGTCACGG	0.547			NA											58	130					0	0	0.01441	0	0
NFAT5	10725	broad.mit.edu	37	16	69726307	69726307	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr16:69726307G>T	uc002exm.1	+	12	3733	c.2525G>T	c.(2524-2526)AGC>ATC	p.S842I	NFAT5_uc002exi.2_Missense_Mutation_p.S766I|NFAT5_uc002exj.1_Missense_Mutation_p.S766I|NFAT5_uc002exk.1_Missense_Mutation_p.S766I|NFAT5_uc002exl.1_Missense_Mutation_p.S860I|NFAT5_uc002exn.1_Missense_Mutation_p.S859I|NFAT5_uc002exo.1_5'Flank	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	842					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						AGTGGTGTAAGCCCTGGAATG	0.403			NA											59	150					1.20869e-33	2.09255e-33	0.01441	1	0
GAN	8139	broad.mit.edu	37	16	81410934	81410934	+	Splice_Site	SNP	G	G	C			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr16:81410934G>C	uc002fgo.2	+	10	1760	c.1612_splice	c.e10+1	p.G538_splice		NM_022041	NP_071324	Q9H2C0	GAN_HUMAN	gigaxonin						cell death	cytoplasm|neurofilament	protein binding			ovary(2)	2		Colorectal(91;0.153)				CTTGATACAGGTAAGAGTGTT	0.408	GBM(106;1239 1507 7582 9741 33976)		NA											45	308					0	0	0.011902	0	0
ZNF778	197320	broad.mit.edu	37	16	89294225	89294225	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr16:89294225G>T	uc002fmv.2	+	6	1784	c.1445G>T	c.(1444-1446)TGT>TTT	p.C482F	ZNF778_uc010vpf.1_Intron|ZNF778_uc002fmw.1_Missense_Mutation_p.C440F|ZNF778_uc010vpg.1_Missense_Mutation_p.C245F	NM_182531	NP_872337	Q96MU6	ZN778_HUMAN	zinc finger protein 778	482	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0269)		TGTAAGCAGTGTGGCAAAGCC	0.493			NA											12	66					9.05144e-12	1.22904e-11	0.001855	1	0
C17orf85	55421	broad.mit.edu	37	17	3721736	3721736	+	Silent	SNP	G	G	C			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr17:3721736G>C	uc010ckl.1	-	10	1154	c.1131C>G	c.(1129-1131)CTC>CTG	p.L377L	C17orf85_uc002fwr.2_Silent_p.L87L|C17orf85_uc002fwq.2_Silent_p.L97L	NM_001114118	NP_001107590	Q53F19	CQ085_HUMAN	ELG protein isoform a	377							nucleotide binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (3;0.0725)		TGAGAGCCGGGAGCTCCTCGT	0.418			NA											27	104					0	0	0.010818	0	0
C17orf74	201243	broad.mit.edu	37	17	7330250	7330250	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr17:7330250C>T	uc002ggw.2	+	3	1013	c.940C>T	c.(940-942)CGG>TGG	p.R314W	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	314						integral to membrane					0		Prostate(122;0.157)				CTGGGATCAGCGGCGTCGTGG	0.706			NA											11	47					0	0	0.003163	0	0
MYH4	4622	broad.mit.edu	37	17	10355258	10355258	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr17:10355258C>A	uc002gmn.2	-	27	3849	c.3738G>T	c.(3736-3738)AAG>AAT	p.K1246N	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1246	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TAATGAAGACCTTGGCTTTGG	0.388			NA											37	117					6.04917e-29	1.02172e-28	0.006999	1	0
DNAH9	1770	broad.mit.edu	37	17	11593391	11593391	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr17:11593391G>T	uc002gne.2	+	20	4320	c.4252G>T	c.(4252-4254)GAT>TAT	p.D1418Y	DNAH9_uc010coo.2_Missense_Mutation_p.D712Y	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1418	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCACTATGAGGATGAGGTCCG	0.562			NA											11	52					5.16669e-11	6.84771e-11	0.010729	1	0
RHBDL3	162494	broad.mit.edu	37	17	30611731	30611731	+	Silent	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr17:30611731G>A	uc002hhe.1	+	3	203	c.189G>A	c.(187-189)CTG>CTA	p.L63L	RHBDL3_uc010csw.1_Silent_p.L55L|RHBDL3_uc010csx.1_Silent_p.L63L|RHBDL3_uc010csy.1_Intron|RHBDL3_uc002hhf.1_Intron	NM_138328	NP_612201	P58872	RHBL3_HUMAN	rhomboid protease 3	63	EF-hand 1.				proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)				GGAGTCTTCTGGAGAGCCACA	0.587			NA											17	59					0	0	0.004007	0	0
MYO19	80179	broad.mit.edu	37	17	34883509	34883509	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr17:34883509C>A	uc010wcy.1	-	6	1165	c.173G>T	c.(172-174)CGG>CTG	p.R58L	MYO19_uc002hmw.2_Missense_Mutation_p.R58L|MYO19_uc010cuu.2_RNA|MYO19_uc010wcz.1_RNA|MYO19_uc010wda.1_Intron|MYO19_uc002hmx.2_Missense_Mutation_p.R58L	NM_001163735	NP_001157207	Q96H55	MYO19_HUMAN	myosin XIX isoform 2	58	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)	1		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TGCCATGTACCGGGCCTGCAG	0.517			NA											11	37					6.40141e-05	7.17891e-05	0.010729	1	0
MRM1	79922	broad.mit.edu	37	17	34964761	34964761	+	Silent	SNP	A	A	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr17:34964761A>G	uc002hne.2	+	5	1187	c.972A>G	c.(970-972)CAA>CAG	p.Q324Q	MRM1_uc002hnf.2_Silent_p.Q129Q	NM_024864	NP_079140	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog	324					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		AAGACCCCCAAGAACCCTCAG	0.567			NA											63	247					0	0	0.01441	0	0
MLX	6945	broad.mit.edu	37	17	40720536	40720536	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr17:40720536A>G	uc002iag.2	+	3	355	c.290A>G	c.(289-291)AAT>AGT	p.N97S	MLX_uc002iaf.2_Missense_Mutation_p.N43S|MLX_uc002iah.2_Intron	NM_170607	NP_733752	Q9UH92	MLX_HUMAN	transcription factor-like protein 4 isoform	97	Helix-loop-helix motif.				energy reserve metabolic process|negative regulation of transcription, DNA-dependent|positive regulation of cellular metabolic process	cytoplasm|nucleus	DNA binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		all_cancers(22;4.26e-05)|Breast(137;0.000153)|all_epithelial(22;0.00148)		BRCA - Breast invasive adenocarcinoma(366;0.129)		TCCAGAGCTAATAGCATCGGT	0.547	GBM(121;657 1601 4665 24731 34640)		NA											68	254					0	0	0.01441	0	0
PRKCA	5578	broad.mit.edu	37	17	64785039	64785040	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr17:64785039_64785040GG>TT	uc002jfp.1	+	16	1840_1841	c.1796_1797GG>TT	c.(1795-1797)AGG>ATT	p.R599I		NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha	599	AGC-kinase C-terminal.				activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	TTCTTCCGGAGGATCGACTGGG	0.564			NA											28	103					0	0	0.004672	0	0
UNC13D	201294	broad.mit.edu	37	17	73836332	73836332	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr17:73836332G>A	uc002jpp.2	-	10	1212	c.832C>T	c.(832-834)CTC>TTC	p.L278F	UNC13D_uc010wsk.1_Missense_Mutation_p.L278F|UNC13D_uc002jpq.1_5'UTR|UNC13D_uc010dgq.1_Missense_Mutation_p.L75F	NM_199242	NP_954712	Q70J99	UN13D_HUMAN	unc-13 homolog D	278	Interaction with RAB27A.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			upper_aerodigestive_tract(1)|skin(1)	2			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			TGGAACTGGAGGTGGCACTGG	0.672			NA							Familial_Hemophagocytic_Lymphohistiocytosis				8	44					0	0	0.013537	0	0
TRIM65	201292	broad.mit.edu	37	17	73887248	73887248	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr17:73887248C>A	uc002jpx.2	-	6	1202	c.1166G>T	c.(1165-1167)CGC>CTC	p.R389L		NM_173547	NP_775818	Q6PJ69	TRI65_HUMAN	tripartite motif-containing 65	389	B30.2/SPRY.					intracellular	zinc ion binding				0			Epithelial(20;7.53e-06)|all cancers(21;9.11e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			GTCTGACGCGCGCACCTCCCA	0.687			NA											15	82					0.00400662	0.0042686	0.004007	1	0
RNF165	494470	broad.mit.edu	37	18	44027602	44027602	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr18:44027602C>A	uc002lcb.1	+	4	613	c.562C>A	c.(562-564)CTA>ATA	p.L188I	RNF165_uc002lby.1_Missense_Mutation_p.L121I|RNF165_uc010dnn.1_5'UTR	NM_152470	NP_689683	Q6ZSG1	RN165_HUMAN	ring finger protein 165	188							zinc ion binding				0				READ - Rectum adenocarcinoma(1;0.0873)		TCAGCATTACCTAGCCACTCC	0.547			NA											42	104					2.35958e-20	3.69268e-20	0.009718	1	0
ABCA7	10347	broad.mit.edu	37	19	1046335	1046335	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:1046335C>A	uc002lqw.3	+	13	1783	c.1552C>A	c.(1552-1554)CTC>ATC	p.L518I	ABCA7_uc010dsb.1_Missense_Mutation_p.L380I	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	518	Extracellular (By similarity).				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGTCCGCGTGCTCAGCGGCGC	0.701			NA											38	363					1.7489e-18	2.61863e-18	0.011902	1	0
CELF5	60680	broad.mit.edu	37	19	3281249	3281249	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:3281249C>T	uc002lxm.2	+	6	693	c.656C>T	c.(655-657)ACG>ATG	p.T219M	CELF5_uc002lxl.1_Missense_Mutation_p.T219M|CELF5_uc010dtj.1_Missense_Mutation_p.T219M|CELF5_uc010xhg.1_Missense_Mutation_p.T105M|CELF5_uc002lxn.2_RNA	NM_021938	NP_068757	Q8N6W0	CELF5_HUMAN	bruno-like 5, RNA binding protein	219					mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			ovary(2)	2						AAGGAGCGGACGCTCCGGCGC	0.677			NA											11	103					0	0	0.006122	0	0
TMIGD2	126259	broad.mit.edu	37	19	4298087	4298087	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:4298087G>T	uc002lzx.1	-	2	348	c.302C>A	c.(301-303)CCT>CAT	p.P101H	TMIGD2_uc010dtv.1_Missense_Mutation_p.P101H	NM_144615	NP_653216	Q96BF3	TMIG2_HUMAN	transmembrane and immunoglobulin domain	101	Extracellular (Potential).|Ig-like.					integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGGCTCACAGGGTCCAGCTG	0.642			NA											38	136					6.2361e-21	9.92759e-21	0.007835	1	0
MUC16	94025	broad.mit.edu	37	19	9076674	9076674	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:9076674G>T	uc002mkp.2	-	3	10976	c.10772C>A	c.(10771-10773)TCC>TAC	p.S3591Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3592	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GACAGTCCAGGAATCTGATGC	0.483			NA											22	135					1.85244e-09	2.33239e-09	0.00333	1	0
MUC16	94025	broad.mit.edu	37	19	9077673	9077673	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:9077673C>A	uc002mkp.2	-	3	9977	c.9773G>T	c.(9772-9774)AGC>ATC	p.S3258I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3259	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGAGAGATGCTGGTGCTGCC	0.527			NA											40	124					1.30998e-17	1.93013e-17	0.005524	1	0
EMR2	30817	broad.mit.edu	37	19	14857057	14857057	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:14857057G>A	uc002mzp.1	-	18	2626	c.2170C>T	c.(2170-2172)CTC>TTC	p.L724F	EMR2_uc010dzs.1_Missense_Mutation_p.L183F|EMR2_uc010xnw.1_Missense_Mutation_p.L666F|EMR2_uc002mzo.1_Missense_Mutation_p.L713F|EMR2_uc002mzq.1_Missense_Mutation_p.L664F|EMR2_uc002mzr.1_Missense_Mutation_p.L675F|EMR2_uc002mzs.1_Missense_Mutation_p.L582F|EMR2_uc002mzt.1_Missense_Mutation_p.L620F|EMR2_uc002mzu.1_Missense_Mutation_p.L631F|EMR2_uc010xnx.1_RNA	NM_013447	NP_038475	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone	724	Cytoplasmic (Potential).				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			lung(2)|ovary(1)|skin(1)	4						GTGTTCCGGAGGGTGGACACT	0.478			NA											80	292					0	0	0.01441	0	0
OR10H1	26539	broad.mit.edu	37	19	15918047	15918047	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:15918047C>A	uc002nbq.2	-	1	890	c.801G>T	c.(799-801)CAG>CAT	p.Q267H		NM_013940	NP_039228	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTTCCAGAGACTGGGGACTTT	0.562			NA											34	82					1.26612e-14	1.81717e-14	0.003271	1	0
SLC5A5	6528	broad.mit.edu	37	19	17994525	17994525	+	Silent	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:17994525C>T	uc002nhr.3	+	11	1625	c.1278C>T	c.(1276-1278)CCC>CCT	p.P426P		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	426	Helical; (Potential).				cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4						TCAGCGGCCCCCTGCTGGGAG	0.547	Melanoma(65;1008 1708 7910 46650)		NA											17	89					0	0	0.008871	0	0
ARRDC2	27106	broad.mit.edu	37	19	18121164	18121164	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:18121164G>C	uc002nhv.2	+	6	1152	c.1009G>C	c.(1009-1011)GAG>CAG	p.E337Q	ARRDC2_uc002nhu.2_Missense_Mutation_p.E332Q	NM_015683	NP_056498	Q8TBH0	ARRD2_HUMAN	arrestin domain containing 2 isoform 1	337										pancreas(1)	1						GGAGCGGCCTGAGGGTAAGCT	0.647			NA											3	57					0	0	0.004672	0	0
CRTC1	23373	broad.mit.edu	37	19	18888001	18888001	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:18888001A>T	uc002nkb.3	+	14	1802	c.1714A>T	c.(1714-1716)AGC>TGC	p.S572C	CRTC1_uc010ebv.2_Missense_Mutation_p.S588C|CRTC1_uc010ebw.2_Missense_Mutation_p.S408C|CRTC1_uc002nkc.3_Missense_Mutation_p.S270C	NM_015321	NP_056136	Q6UUV9	CRTC1_HUMAN	mucoepidermoid carcinoma translocated 1 isoform	572					interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding	p.S572fs*4(1)	CRTC1/MAML2(516)	salivary_gland(474)|lung(35)|thyroid(4)|breast(3)|skin(2)|ovary(1)	519						GTCCCCCCCCAGCCTCTCTAA	0.627			NA											21	71					0	0	0.00278	0	0
ZNF536	9745	broad.mit.edu	37	19	31025803	31025803	+	Silent	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:31025803G>T	uc002nsu.1	+	3	2358	c.2220G>T	c.(2218-2220)CTG>CTT	p.L740L	ZNF536_uc010edd.1_Silent_p.L740L	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	740					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					AACCAGCGCTGCTTCGCGACA	0.567			NA											64	204					1.31726e-23	2.17191e-23	0.01441	1	0
LSM14A	26065	broad.mit.edu	37	19	34706112	34706112	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:34706112G>T	uc002nvb.3	+	5	818	c.622G>T	c.(622-624)GCT>TCT	p.A208S	LSM14A_uc002nva.3_Missense_Mutation_p.A208S|LSM14A_uc010xru.1_Missense_Mutation_p.A167S|LSM14A_uc002nvc.3_Missense_Mutation_p.A14S	NM_001114093	NP_001107565	Q8ND56	LS14A_HUMAN	LSM14 homolog A isoform a	208					cytoplasmic mRNA processing body assembly|multicellular organismal development|regulation of translation	cytoplasmic mRNA processing body|intracellular membrane-bounded organelle|stress granule				skin(1)	1	Esophageal squamous(110;0.162)					CCACTTACCTGCTCCAGCAGC	0.527			NA											20	59					8.04996e-18	1.19243e-17	0.012319	1	0
ZFP14	57677	broad.mit.edu	37	19	36832235	36832235	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:36832235C>G	uc002odx.1	-	4	586	c.493G>C	c.(493-495)GTT>CTT	p.V165L	ZFP14_uc010xtd.1_Missense_Mutation_p.V166L|ZFP14_uc010eex.1_Missense_Mutation_p.V165L	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					CCATTATGAACGATCTGATAC	0.383			NA											50	190					0	0	0.01441	0	0
PSG3	5671	broad.mit.edu	37	19	43233410	43233410	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:43233410C>T	uc002oue.2	-	5	1240	c.1108G>A	c.(1108-1110)GGG>AGG	p.G370R	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Missense_Mutation_p.G370R|PSG3_uc010eil.2_Missense_Mutation_p.G392R	NM_021016	NP_066296	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	370	Ig-like C2-type 3.			Missing (in Ref. 9).	defense response|female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				TGAAACTTCCCATTAATTGTC	0.443			NA											80	309					0	0	0.01441	0	0
RTN2	6253	broad.mit.edu	37	19	45992753	45992753	+	Silent	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:45992753C>T	uc002pcb.2	-	6	1320	c.1092G>A	c.(1090-1092)CTG>CTA	p.L364L	RTN2_uc002pcc.2_Silent_p.L291L|RTN2_uc002pcd.2_RNA	NM_005619	NP_005610	O75298	RTN2_HUMAN	reticulon 2 isoform A	364	Reticulon.					integral to endoplasmic reticulum membrane	signal transducer activity			ovary(3)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)		GGGAGACCATCAGGCCTGTGA	0.617			NA											9	15					0	0	0.004482	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51628373	51628373	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:51628373C>A	uc002pvu.2	+	1	209	c.142C>A	c.(142-144)CAT>AAT	p.H48N	SIGLEC9_uc010yct.1_Missense_Mutation_p.H48N	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	48	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		CTACCCCTCGCATGGCTGGAT	0.582			NA											18	59					1.9806e-07	2.375e-07	0.014323	1	0
SIGLEC12	89858	broad.mit.edu	37	19	51994930	51994930	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:51994930C>T	uc002pwx.1	-	8	1809	c.1753G>A	c.(1753-1755)GGC>AGC	p.G585S	SIGLEC12_uc002pww.1_Missense_Mutation_p.G467S|SIGLEC12_uc010eoy.1_Missense_Mutation_p.G312S	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	585	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TACTCATAGCCGATGGCCTCC	0.582			NA											52	107					0	0	0.01441	0	0
ZNF880	400713	broad.mit.edu	37	19	52876489	52876489	+	Silent	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:52876489G>T	uc002pzc.2	+	2	187	c.138G>T	c.(136-138)CTG>CTT	p.L46L	ZNF880_uc002pzb.3_RNA	NM_001145434	NP_001138906	Q6PDB4	ZN880_HUMAN	zinc finger protein LOC400713	46	KRAB.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						TGGTCTTTCTGGGTGAGGATA	0.468			NA											11	76					9.31168e-06	1.06584e-05	0.001855	1	0
ZNF665	79788	broad.mit.edu	37	19	53678823	53678823	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:53678823C>A	uc010eqm.1	-	3	117	c.17G>T	c.(16-18)GGA>GTA	p.G6V		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	Error:Variant_position_missing_in_Q9H7R5_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		TGTCAACTGTCCCTAAAATGA	0.418			NA											26	121					1.39806e-14	1.99619e-14	0.008361	1	0
CCDC106	29903	broad.mit.edu	37	19	56160839	56160839	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:56160839G>T	uc002qlr.2	+	4	937	c.202G>T	c.(202-204)GCT>TCT	p.A68S	CCDC106_uc002qls.2_Missense_Mutation_p.A68S	NM_013301	NP_037433	Q9BWC9	CC106_HUMAN	coiled-coil domain containing 106	68	Potential.					nucleus					0		Colorectal(82;0.00403)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		GCTGCACATGGCTCTGGAGAG	0.622			NA											17	52					9.16793e-09	1.11873e-08	0.00499	1	0
NLRP4	147945	broad.mit.edu	37	19	56363727	56363727	+	Splice_Site	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:56363727G>T	uc002qmd.3	+	2	702	c.280_splice	c.e2+1	p.G94_splice		NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4								ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GAGAGAACAGGTGAGGGAGTC	0.438			NA											17	88					6.94344e-10	8.78235e-10	0.006122	1	0
ZNF418	147686	broad.mit.edu	37	19	58439201	58439201	+	Silent	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr19:58439201C>T	uc002qqs.1	-	4	640	c.348G>A	c.(346-348)GGG>GGA	p.G116G	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Silent_p.G31G	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	116					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		ACAATTTATTCCCCCATGCCT	0.468			NA											19	222					0	0	0.007413	0	0
ZNF512	84450	broad.mit.edu	37	2	27844189	27844189	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr2:27844189G>C	uc002rla.2	+	14	1652	c.1565G>C	c.(1564-1566)AGA>ACA	p.R522T	ZNF512_uc010ylv.1_Missense_Mutation_p.R443T|ZNF512_uc010ylw.1_Missense_Mutation_p.R493T|ZNF512_uc002rlb.2_Missense_Mutation_p.R443T|ZNF512_uc010ylx.1_Missense_Mutation_p.R443T|ZNF512_uc002rlc.2_Missense_Mutation_p.R443T|ZNF512_uc010yly.1_Intron|ZNF512_uc010ylz.1_Missense_Mutation_p.R415T	NM_032434	NP_115810	Q96ME7	ZN512_HUMAN	zinc finger protein 512	522					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					CTGAGTCTTAGAGTAGGGAAG	0.532			NA											3	102					0	0	0.004672	0	0
LCLAT1	253558	broad.mit.edu	37	2	30863299	30863299	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr2:30863299G>C	uc002rnj.2	+	7	1268	c.1059G>C	c.(1057-1059)TGG>TGC	p.W353C	LCLAT1_uc010ymp.1_Missense_Mutation_p.W191C|LCLAT1_uc002rnl.2_Missense_Mutation_p.W315C|LCLAT1_uc010ymq.1_Missense_Mutation_p.W315C	NM_182551	NP_872357	Q6UWP7	LCLT1_HUMAN	lysocardiolipin acyltransferase 1 isoform 1	353	Helical; (Potential).				multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			ovary(2)	2						TACTGTATTGGACCCTGTTCA	0.403			NA											51	158					0	0	0.01441	0	0
THADA	63892	broad.mit.edu	37	2	43801837	43801837	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr2:43801837G>A	uc002rsw.3	-	11	1719	c.1367C>T	c.(1366-1368)ACG>ATG	p.T456M	THADA_uc002rsx.3_Missense_Mutation_p.T456M|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_RNA|THADA_uc002rsz.2_Missense_Mutation_p.T166M|THADA_uc002rta.2_Missense_Mutation_p.T166M|THADA_uc002rtb.1_Missense_Mutation_p.T456M|THADA_uc002rtc.3_Missense_Mutation_p.T456M|THADA_uc002rtd.2_Missense_Mutation_p.T456M	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	456							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				ACCAAGGCACGTGTACTTTCC	0.418			NA											31	98					0	0	0.012213	0	0
LRPPRC	10128	broad.mit.edu	37	2	44204416	44204416	+	Splice_Site	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr2:44204416C>A	uc002rtr.2	-	4	528	c.470_splice	c.e4-1	p.G157_splice	LRPPRC_uc010yob.1_Splice_Site_p.G57_splice|LRPPRC_uc010faw.1_Splice_Site_p.G131_splice	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein						mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TACACAGCACCTACAAATGAA	0.289			NA											4	20					3.59834e-05	4.05178e-05	0.001168	1	0
LRRTM4	80059	broad.mit.edu	37	2	77746912	77746912	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr2:77746912G>T	uc002snr.2	-	3	498	c.83C>A	c.(82-84)ACG>AAG	p.T28K	LRRTM4_uc002snq.2_Missense_Mutation_p.T28K|LRRTM4_uc002sns.2_Missense_Mutation_p.T28K|LRRTM4_uc002snt.2_Missense_Mutation_p.T29K	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	28						integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		CTGAGCACCCGTGAGCATAAC	0.443			NA											12	31					5.16669e-11	6.84771e-11	0.010729	1	0
RETSAT	54884	broad.mit.edu	37	2	85571154	85571154	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr2:85571154C>A	uc002spd.2	-	9	1692	c.1501G>T	c.(1501-1503)GTC>TTC	p.V501F	RETSAT_uc010fge.2_Intron|RETSAT_uc010ysm.1_Missense_Mutation_p.V440F|RETSAT_uc010fgf.2_Missense_Mutation_p.V292F	NM_017750	NP_060220	Q6NUM9	RETST_HUMAN	all-trans-13,14-dihydroretinol saturase	501					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			ovary(2)	2					Vitamin A(DB00162)	AGTTTCAGGACCACTGACATA	0.537			NA											43	170					8.00217e-19	1.21791e-18	0.01441	1	0
FAM123C	205147	broad.mit.edu	37	2	131519874	131519874	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr2:131519874G>C	uc002trw.2	+	2	419	c.229G>C	c.(229-231)GGA>CGA	p.G77R	FAM123C_uc010fmv.2_Missense_Mutation_p.G77R|FAM123C_uc010fms.1_Missense_Mutation_p.G77R|FAM123C_uc010fmt.1_Missense_Mutation_p.G77R|FAM123C_uc010fmu.1_Missense_Mutation_p.G77R	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	77										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		CCCCAAAGGGGGACCCGCAGC	0.647			NA											3	18					0	0	0.009096	0	0
LCT	3938	broad.mit.edu	37	2	136566318	136566318	+	Missense_Mutation	SNP	G	G	C	rs148317168		TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr2:136566318G>C	uc002tuu.1	-	8	3610	c.3599C>G	c.(3598-3600)ACG>AGG	p.T1200R		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1200	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		GACGTCGGCCGTCGCCCTGAT	0.557			NA											39	174					0	0	0.007835	0	0
LRP1B	53353	broad.mit.edu	37	2	141751656	141751656	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr2:141751656C>G	uc002tvj.1	-	16	3524	c.2552G>C	c.(2551-2553)CGC>CCC	p.R851P	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	851	Extracellular (Potential).|LDL-receptor class A 3.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTTTTTGCAGCGAAACTCTCC	0.438	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			19	90					0	0	0.010504	0	0
ORC4L	5000	broad.mit.edu	37	2	148715893	148715893	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr2:148715893C>A	uc002twi.2	-	6	496	c.361G>T	c.(361-363)GAA>TAA	p.E121*	ORC4L_uc002twj.2_Nonsense_Mutation_p.E121*|ORC4L_uc010zbo.1_Nonsense_Mutation_p.E47*|ORC4L_uc010zbp.1_5'UTR|ORC4L_uc010fnr.2_Nonsense_Mutation_p.E121*|ORC4L_uc010zbq.1_Nonsense_Mutation_p.E37*|ORC4L_uc002twk.2_Nonsense_Mutation_p.E121*|ORC4L_uc010zbr.1_Nonsense_Mutation_p.E121*	NM_181741	NP_859525	O43929	ORC4_HUMAN	origin recognition complex subunit 4	121					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|nucleoside-triphosphatase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.0963)|COAD - Colon adenocarcinoma(177;0.203)		ACTACATTTTCCAGATTTAAC	0.254			NA											6	21					8.12818e-05	9.07866e-05	0.001984	1	0
GALNT13	114805	broad.mit.edu	37	2	154801038	154801038	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr2:154801038G>T	uc002tyr.3	+	3	595	c.28G>T	c.(28-30)GTT>TTT	p.V10F	GALNT13_uc002tyt.3_Missense_Mutation_p.V10F	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	10	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CTGCAAGGTGGTTCTAGCCAC	0.413			NA											34	121					4.44401e-20	6.83884e-20	0.010771	1	0
CHRNA1	1134	broad.mit.edu	37	2	175624091	175624091	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr2:175624091G>A	uc002ujd.2	-	3	280	c.202C>T	c.(202-204)CAG>TAG	p.Q68*	uc002uiw.2_Intron|CHRNA1_uc002uje.2_Nonsense_Mutation_p.Q68*|CHRNA1_uc002ujf.3_Nonsense_Mutation_p.Q68*	NM_001039523	NP_001034612	P02708	ACHA_HUMAN	nicotinic cholinergic receptor alpha 1 isoform a	68	Extracellular.				muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GTCACGATCTGATTTACTTCA	0.473			NA											30	126					0	0	0.010818	0	0
TTC30B	150737	broad.mit.edu	37	2	178417000	178417000	+	Silent	SNP	G	G	C			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr2:178417000G>C	uc002uln.2	-	1	525	c.492C>G	c.(490-492)CTC>CTG	p.L164L	TTC30B_uc010zfc.1_5'UTR	NM_152517	NP_689730	Q8N4P2	TT30B_HUMAN	tetratricopeptide repeat domain 30B	164	TPR 3.				cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)			CCTCCTTGTAGAGCAAACAAC	0.582			NA											13	444					0	0	0.001855	0	0
TTN	7273	broad.mit.edu	37	2	179650354	179650354	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr2:179650354C>G	uc010zfg.1	-	15	2710	c.2486G>C	c.(2485-2487)GGA>GCA	p.G829A	TTN_uc010zfh.1_Missense_Mutation_p.G783A|TTN_uc010zfi.1_Missense_Mutation_p.G783A|TTN_uc010zfj.1_Missense_Mutation_p.G783A|TTN_uc002unb.2_Missense_Mutation_p.G829A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	829							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACCTCATATCCATGTTCTGT	0.413			NA											19	60					0	0	0.008871	0	0
ICA1L	130026	broad.mit.edu	37	2	203686132	203686132	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr2:203686132C>T	uc002uzh.1	-	5	472	c.308G>A	c.(307-309)GGC>GAC	p.G103D	ICA1L_uc002uzi.1_Missense_Mutation_p.G103D|ICA1L_uc002uzj.2_Missense_Mutation_p.G103D	NM_138468	NP_612477	Q8NDH6	ICA1L_HUMAN	islet cell autoantigen 1,69kDa-like isoform 1	103	AH.										0						CATCATTTTGCCAGCTTGAGT	0.383			NA											31	110					0	0	0.013726	0	0
CPS1	1373	broad.mit.edu	37	2	211459298	211459298	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr2:211459298C>T	uc002vee.3	+	12	1363	c.1231C>T	c.(1231-1233)CCG>TCG	p.P411S	CPS1_uc010fur.2_Missense_Mutation_p.P417S|CPS1_uc010fus.2_5'UTR	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	411					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		ATCAGTCTTACCGAAGCCAGC	0.363			NA											7	32					0	0	0.006214	0	0
VIL1	7429	broad.mit.edu	37	2	219296603	219296603	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr2:219296603G>A	uc002via.2	+	11	1191	c.1126G>A	c.(1126-1128)GAT>AAT	p.D376N	VIL1_uc010zke.1_Missense_Mutation_p.D65N|VIL1_uc002vib.2_Missense_Mutation_p.D376N	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	376	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGTGAAGTTCGATGCCACATC	0.488			NA											9	30					0	0	0.004482	0	0
NGEF	25791	broad.mit.edu	37	2	233785096	233785096	+	Silent	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr2:233785096G>A	uc002vts.2	-	5	974	c.726C>T	c.(724-726)CTC>CTT	p.L242L	NGEF_uc010fyg.1_Silent_p.L150L|NGEF_uc002vtt.2_Silent_p.L150L	NM_019850	NP_062824	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	242	Regulatory region; modulates activity toward RHOA, RAC1 and CDC42 (By similarity).				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)|skin(1)	7		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		GGGGGTTACTGAGCAGGCAGA	0.517			NA											6	90					0	0	0.001168	0	0
CYP24A1	1591	broad.mit.edu	37	20	52781004	52781004	+	Silent	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr20:52781004G>T	uc002xwv.2	-	6	1229	c.831C>A	c.(829-831)ACC>ACA	p.T277T	CYP24A1_uc002xwu.1_Silent_p.T135T|CYP24A1_uc002xww.2_Silent_p.T277T	NM_000782	NP_000773	Q07973	CP24A_HUMAN	cytochrome P450 family 24 subfamily A	277					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	ATTTGAAAATGGTGTCCCAGG	0.567			NA											40	131					2.05212e-20	3.22975e-20	0.005524	1	0
TAF4	6874	broad.mit.edu	37	20	60575636	60575636	+	Silent	SNP	C	C	A	rs149271691	byFrequency	TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr20:60575636C>A	uc002ybs.2	-	10	2628	c.2628G>T	c.(2626-2628)GCG>GCT	p.A876A		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	876					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			TCTGCAAAGGCGCTTGGAGGA	0.458			NA											41	179					5.20006e-24	8.62525e-24	0.011902	1	0
TMPRSS15	5651	broad.mit.edu	37	21	19713778	19713778	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr21:19713778G>T	uc002ykw.2	-	13	1547	c.1516C>A	c.(1516-1518)CTT>ATT	p.L506I		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	506	Extracellular (Potential).				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						TCTGGATAAAGACTCCCATTG	0.358			NA											22	91					9.95505e-16	1.44374e-15	0.014323	1	0
GRIK1	2897	broad.mit.edu	37	21	31311771	31311771	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr21:31311771G>T	uc002yno.1	-	1	512	c.48C>A	c.(46-48)GAC>GAA	p.D16E	GRIK1_uc002ynn.2_Missense_Mutation_p.D16E|GRIK1_uc011acs.1_Missense_Mutation_p.D16E|GRIK1_uc011act.1_Missense_Mutation_p.D16E|GRIK1_uc010glq.1_Missense_Mutation_p.D16E|GRIK1_uc002ynr.2_Missense_Mutation_p.D16E	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	16					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CCCAGCTGGTGTCCCTGGTCC	0.622			NA											10	16					0.000442599	0.000477043	0.006214	1	0
KRTAP10-4	386672	broad.mit.edu	37	21	45993646	45993646	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr21:45993646G>A	uc002zfk.1	+	1	41	c.11G>A	c.(10-12)TGC>TAC	p.C4Y	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198687	NP_941960	P60372	KR104_HUMAN	keratin associated protein 10-4	4						keratin filament					0						ATGTCCGTCTGCTCCAGCGAC	0.632			NA											21	86					0	0	0.012319	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072423	17072423	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr22:17072423G>T	uc002zlp.1	-	1	1278	c.1018C>A	c.(1018-1020)CCT>ACT	p.P340T		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	340					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CTCTGGGGAGGGAGCAGACGA	0.552			NA											17	184					6.49762e-13	8.95443e-13	0.006122	1	0
MICAL3	57553	broad.mit.edu	37	22	18301821	18301821	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr22:18301821C>A	uc002zng.3	-	26	3959	c.3606G>T	c.(3604-3606)TTG>TTT	p.L1202F	MICAL3_uc011agl.1_Missense_Mutation_p.L1118F	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1202	Pro-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		CTTTGGGGAGCAAAGGCTCAG	0.602			NA											6	29					3.59834e-05	4.05178e-05	0.001168	1	0
SNRPD3	6634	broad.mit.edu	37	22	24964111	24964111	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr22:24964111G>T	uc003aam.1	+	3	726	c.286G>T	c.(286-288)GGC>TGC	p.G96C	SNRPD3_uc011aju.1_Missense_Mutation_p.G96C	NM_004175	NP_004166	P62318	SMD3_HUMAN	small nuclear ribonucleoprotein polypeptide D3	96	Arg/Lys-rich (basic).				histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	enzyme binding|histone pre-mRNA DCP binding			ovary(1)	1						CTCAGGGGCTGGCCGAGGAAA	0.458			NA											16	50					2.94398e-08	3.54558e-08	0.007413	1	0
LOC644165	644165	broad.mit.edu	37	22	25045888	25045888	+	Silent	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr22:25045888C>T	uc011ajv.1	+	6	969	c.612C>T	c.(610-612)GCC>GCT	p.A204A	POM121L10P_uc003aaz.3_Intron|POM121L10P_uc003abc.2_Intron	NR_024494				Homo sapiens cDNA FLJ57042 complete cds, moderately similar to Breakpoint cluster region protein (EC 2.7.11.1).												0						TGTCTTTGGCCCCACGCTGCT	0.607			NA											4	17					0	0	0.001168	0	0
HPS4	89781	broad.mit.edu	37	22	26860631	26860631	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr22:26860631C>A	uc003acl.2	-	11	1624	c.965G>T	c.(964-966)AGG>ATG	p.R322M	HPS4_uc003aci.2_Missense_Mutation_p.R317M|HPS4_uc003acj.2_Missense_Mutation_p.R186M|HPS4_uc003ack.2_Missense_Mutation_p.R113M|HPS4_uc003acn.2_Missense_Mutation_p.R168M|HPS4_uc010gvd.1_Missense_Mutation_p.R340M|HPS4_uc003ach.2_Missense_Mutation_p.R57M	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	322					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						GTTCTCCTTCCTGCCATCTGG	0.587			NA							Hermansky-Pudlak_syndrome				21	87					2.44723e-14	3.47632e-14	0.004656	1	0
SSTR3	6753	broad.mit.edu	37	22	37602771	37602771	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr22:37602771C>A	uc003ara.2	-	2	1134	c.1072G>T	c.(1072-1074)GGG>TGG	p.G358W	SSTR3_uc003arb.2_Missense_Mutation_p.G358W	NM_001051	NP_001042	P32745	SSR3_HUMAN	somatostatin receptor 3	358	Cytoplasmic (Potential).|Glu-rich (acidic).				G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			lung(1)	1						CTctcctccccatcctcctcc	0.602			NA											21	48					1.22574e-08	1.48916e-08	0.014323	1	0
KCNJ4	3761	broad.mit.edu	37	22	38822911	38822911	+	Silent	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr22:38822911C>T	uc003avs.1	-	2	1324	c.1227G>A	c.(1225-1227)GAG>GAA	p.E409E	KCNJ4_uc003avt.1_Silent_p.E409E	NM_004981	NP_004972	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel J4	409	Cytoplasmic (By similarity).				synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding				0	Melanoma(58;0.0286)					TGCCCGCCTCCTCCTTGGAAC	0.677			NA											15	89					0	0	0.007291	0	0
CPT1B	1375	broad.mit.edu	37	22	51012810	51012810	+	Silent	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr22:51012810C>T	uc003bmk.3	-	8	1086	c.924G>A	c.(922-924)CAG>CAA	p.Q308Q	CPT1B_uc003bml.2_Silent_p.Q308Q|CPT1B_uc003bmm.2_Silent_p.Q308Q|CPT1B_uc003bmo.2_Silent_p.Q308Q|CPT1B_uc011asa.1_Silent_p.Q274Q|CPT1B_uc003bmn.2_Silent_p.Q308Q|CPT1B_uc011asb.1_Silent_p.Q308Q|CHKB-CPT1B_uc003bmp.2_Silent_p.Q105Q	NM_001145137	NP_001138609	Q92523	CPT1B_HUMAN	carnitine palmitoyltransferase 1B isoform a	308	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)	2		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)		TCCTCTCCATCTGGTAGGAGC	0.612	Esophageal Squamous(170;988 1933 25577 30295 48163)		NA											6	33					0	0	0.001168	0	0
CLASP2	23122	broad.mit.edu	37	3	33586292	33586292	+	Silent	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr3:33586292G>A	uc003cfu.2	-	30	3549	c.3195C>T	c.(3193-3195)ACC>ACT	p.T1065T	CLASP2_uc003cfs.2_Silent_p.T272T|CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA|CLASP2_uc011axt.1_Silent_p.T665T	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	1074										ovary(3)|central_nervous_system(1)	4						TAAACTCTGGGGTATTGAGTT	0.373			NA											6	21					0	0	0.00308	0	0
ATRIP	84126	broad.mit.edu	37	3	48501913	48501913	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr3:48501913G>A	uc003ctf.1	+	8	1492	c.1460G>A	c.(1459-1461)TGC>TAC	p.C487Y	ATRIP_uc011bbj.1_Missense_Mutation_p.C360Y|ATRIP_uc003ctg.1_Missense_Mutation_p.C487Y|TREX1_uc010hjy.2_Intron	NM_130384	NP_569055	Q8WXE1	ATRIP_HUMAN	ATR interacting protein isoform 1	487					DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CACCTGGTGTGCCACAGCGGA	0.562			NA						Other_conserved_DNA_damage_response_genes					31	113					0	0	0.013726	0	0
CELSR3	1951	broad.mit.edu	37	3	48685348	48685348	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr3:48685348C>T	uc003cul.2	-	20	7336	c.7055G>A	c.(7054-7056)CGA>CAA	p.R2352Q	CELSR3_uc003cuf.1_Missense_Mutation_p.R2422Q|CELSR3_uc010hkg.2_Missense_Mutation_p.R335Q	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2352	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ATCCTGGCCTCGAAAGAGGTT	0.632			NA											5	298					0	0	0.001984	0	0
TLR9	54106	broad.mit.edu	37	3	52257313	52257313	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr3:52257313T>G	uc003dda.1	-	2	1653	c.1019A>C	c.(1018-1020)AAC>ACC	p.N340T	TLR9_uc003ddb.2_Missense_Mutation_p.N437T	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	340	LRR 11.|Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	GAAGGACAGGTTAAGCTTGCG	0.557			NA											24	104					0	0	0.00632	0	0
PROS1	5627	broad.mit.edu	37	3	93624636	93624636	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr3:93624636T>A	uc003drb.3	-	6	934	c.593A>T	c.(592-594)GAT>GTT	p.D198V	PROS1_uc010hoo.2_Missense_Mutation_p.D67V|PROS1_uc003dqz.3_Missense_Mutation_p.D67V	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	198	EGF-like 2; calcium-binding (Potential).				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	ACCTTTACAATCTTTCTTATT	0.303			NA											22	59					0	0	0.010504	0	0
EPHA6	285220	broad.mit.edu	37	3	96706352	96706352	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr3:96706352G>T	uc010how.1	+	3	672	c.629G>T	c.(628-630)TGG>TTG	p.W210L	EPHA6_uc003drp.1_Missense_Mutation_p.W210L	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	115	Ephrin-binding.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						AGCATCCCATGGGTCTTGGGG	0.398			NA											22	86					1.50039e-11	2.02736e-11	0.012319	1	0
SENP7	57337	broad.mit.edu	37	3	101047372	101047372	+	Silent	SNP	T	T	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr3:101047372T>A	uc003dut.2	-	22	2925	c.2814A>T	c.(2812-2814)CTA>CTT	p.L938L	SENP7_uc003duu.2_Silent_p.L873L|SENP7_uc003duv.2_Silent_p.L905L|SENP7_uc003duw.2_Silent_p.L872L|SENP7_uc003dux.2_Silent_p.L774L|SENP7_uc003dus.2_Silent_p.L126L	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	938	Protease.				proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5						TCAAGGAGTCTAGTATAAGAA	0.308			NA											13	74					0	0	0.00245	0	0
CASR	846	broad.mit.edu	37	3	122002643	122002643	+	Silent	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr3:122002643C>T	uc003eev.3	+	7	2214	c.1842C>T	c.(1840-1842)ATC>ATT	p.I614I	CASR_uc003eew.3_Silent_p.I624I	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	614	Helical; Name=1; (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CCTTTGGGATCGCACTCACCC	0.537			NA											24	90					0	0	0.014323	0	0
PCOLCE2	26577	broad.mit.edu	37	3	142548567	142548567	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr3:142548567G>A	uc003evd.2	-	6	1028	c.832C>T	c.(832-834)CAG>TAG	p.Q278*		NM_013363	NP_037495	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	278						extracellular region	collagen binding|heparin binding|peptidase activator activity			ovary(2)|skin(1)	3						GTGACAGGCTGTTCTGTAGTT	0.368			NA											33	167					0	0	0.012213	0	0
MED12L	116931	broad.mit.edu	37	3	151127077	151127077	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr3:151127077C>A	uc003eyp.2	+	38	5800	c.5762C>A	c.(5761-5763)CCC>CAC	p.P1921H	MED12L_uc011bnz.1_Intron	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1921	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CAAGCACGGCCCTCCCCTCAG	0.527			NA											23	131					1.64293e-13	2.27546e-13	0.00333	1	0
MCF2L2	23101	broad.mit.edu	37	3	182897375	182897375	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr3:182897375C>T	uc003fli.1	-	29	3301	c.3211G>A	c.(3211-3213)GAG>AAG	p.E1071K		NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	1071					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GTTTCCTCCTCATCGCGTTCT	0.562			NA											12	76					0	0	0.001855	0	0
LMLN	89782	broad.mit.edu	37	3	197707307	197707307	+	Silent	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr3:197707307C>T	uc011buo.1	+	6	682	c.660C>T	c.(658-660)ACC>ACT	p.T220T	LMLN_uc003fyt.2_Silent_p.T168T|LMLN_uc010iar.2_Silent_p.T220T|LMLN_uc010ias.2_Silent_p.T168T|LMLN_uc003fyu.2_5'UTR	NM_033029	NP_149018	Q96KR4	LMLN_HUMAN	leishmanolysin-like isoform 2	220					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		CTCTGGCCACCGAGAGATGCA	0.502			NA											32	147					0	0	0.011902	0	0
TECRL	253017	broad.mit.edu	37	4	65274940	65274940	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr4:65274940C>A	uc003hcv.2	-	1	239	c.130G>T	c.(130-132)GGC>TGC	p.G44C	TECRL_uc003hcw.2_Missense_Mutation_p.G44C	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	44					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						CTTAGAGGGCCCGCTGAGAGT	0.393			NA											18	31					8.34094e-07	9.87367e-07	0.008871	1	0
ADH7	131	broad.mit.edu	37	4	100340244	100340244	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr4:100340244C>A	uc003huv.1	-	7	995	c.896G>T	c.(895-897)GGG>GTG	p.G299V		NM_000673	NP_000664	P40394	ADH7_HUMAN	class IV alcohol dehydrogenase, mu or sigma	299					ethanol oxidation|fatty acid omega-oxidation|response to bacterium|response to ethanol|xenobiotic metabolic process	cytosol|soluble fraction	alcohol dehydrogenase activity, zinc-dependent|aldehyde oxidase activity|ethanol binding|receptor antagonist activity|retinol binding|retinol dehydrogenase activity			lung(2)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;1.75e-08)	NADH(DB00157)	CACGCTGGTCCCATAGTTCAT	0.493			NA											22	23					6.44725e-10	8.19215e-10	0.014323	1	0
SH3RF1	57630	broad.mit.edu	37	4	170017740	170017740	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr4:170017740C>G	uc003isa.1	-	12	2932	c.2597G>C	c.(2596-2598)TGG>TCG	p.W866S		NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	866	SH3 4.					Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		GCCTTTGAACCAGCCATCCTC	0.428			NA											11	140					0	0	0.010729	0	0
VEGFC	7424	broad.mit.edu	37	4	177608435	177608435	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr4:177608435G>A	uc003ius.1	-	6	1481	c.1051C>T	c.(1051-1053)CAA>TAA	p.Q351*		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	351	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.|4.				angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		TTTAGGGGTTGATTTCTGGGG	0.428			NA											166	258					0	0	0.01441	0	0
FAM105B	90268	broad.mit.edu	37	5	14693081	14693081	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr5:14693081C>T	uc003jfk.2	+	7	1135	c.983C>T	c.(982-984)CCA>CTA	p.P328L		NM_138348	NP_612357	Q96BN8	F105B_HUMAN	hypothetical protein LOC90268	328										ovary(2)	2	Lung NSC(4;0.00696)					AAGGACTGGCCAGTGGTAACG	0.562			NA											22	55					0	0	0.014323	0	0
HTR1A	3350	broad.mit.edu	37	5	63256504	63256504	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr5:63256504C>T	uc011cqt.1	-	1	1043	c.1043G>A	c.(1042-1044)GGC>GAC	p.G348D		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	348	Helical; Name=6; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	CATGATGATGCCCAGCGTCTT	0.602			NA											32	169					0	0	0.00623	0	0
CWC27	10283	broad.mit.edu	37	5	64081315	64081315	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr5:64081315G>T	uc003jtn.1	+	5	623	c.404G>T	c.(403-405)GGG>GTG	p.G135V	CWC27_uc003jtl.2_Missense_Mutation_p.G135V|CWC27_uc003jtm.2_Missense_Mutation_p.G135V|CWC27_uc010iwt.1_Missense_Mutation_p.G135V	NM_005869	NP_005860	Q6UX04	CWC27_HUMAN	serologically defined colon cancer antigen 10	135	PPIase cyclophilin-type.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity				0						TAGGTTACAGGGGATACAGTA	0.308			NA											10	72					1.56452e-12	2.13484e-12	0.007413	1	0
F2R	2149	broad.mit.edu	37	5	76028404	76028404	+	Silent	SNP	A	A	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr5:76028404A>T	uc003ken.3	+	2	619	c.354A>T	c.(352-354)CCA>CCT	p.P118P		NM_001992	NP_001983	P25116	PAR1_HUMAN	coagulation factor II receptor precursor	118	Helical; Name=1; (Potential).				activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity			ovary(3)	3		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	TCAGCCTCCCACTAAACATCA	0.517			NA											53	212					0	0	0.01441	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102522089	102522089	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr5:102522089G>T	uc003kod.3	+	27	3757	c.3238G>T	c.(3238-3240)GAT>TAT	p.D1080Y	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Missense_Mutation_p.D1080Y|PPIP5K2_uc003kof.2_Intron	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	1080					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2						TAACCTACAGGATTATGCTCG	0.493			NA											20	51					3.62473e-10	4.64838e-10	0.012319	1	0
FNIP1	96459	broad.mit.edu	37	5	131008460	131008460	+	Silent	SNP	A	A	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr5:131008460A>G	uc003kvs.1	-	14	1819	c.1677T>C	c.(1675-1677)GAT>GAC	p.D559D	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Silent_p.D531D|FNIP1_uc010jdm.1_Silent_p.D514D	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	559					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		CGATGGCTTCATCTTCTCCAT	0.363			NA											11	136					0	0	0.00245	0	0
SLC22A4	6583	broad.mit.edu	37	5	131663013	131663013	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr5:131663013T>C	uc003kwq.2	+	5	1033	c.868T>C	c.(868-870)TTT>CTT	p.F290L	SLC22A4_uc010jdq.1_RNA|uc003kwr.3_Intron	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	solute carrier family 22 member 4	290	Cytoplasmic (Potential).				body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	CCAGAGAAGATTTAGAGAGGC	0.363			NA											15	49					0	0	0.003163	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182645	140182645	+	Silent	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr5:140182645G>A	uc003lhf.2	+	1	1863	c.1863G>A	c.(1861-1863)CCG>CCA	p.P621P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.P621P	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	621	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGCATCCCGTTTCGCGTGG	0.667			NA											16	79					0	0	0.00499	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503215	140503215	+	Silent	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr5:140503215G>A	uc003lip.1	+	1	1635	c.1635G>A	c.(1633-1635)CTG>CTA	p.L545L		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	545	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGAGGCGCTGGTGCGCGTGC	0.692			NA											8	87					0	0	0.004482	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711965	140711965	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr5:140711965T>A	uc003lji.1	+	1	1714	c.1714T>A	c.(1714-1716)TCT>ACT	p.S572T	PCDHGA1_uc011dan.1_Missense_Mutation_p.S572T	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	572	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACAGATGGTTCTACCGGCGT	0.662			NA											68	181					0	0	0.01441	0	0
PCDHGB5	56101	broad.mit.edu	37	5	140778496	140778496	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr5:140778496G>T	uc003lkf.1	+	1	802	c.802G>T	c.(802-804)GAC>TAC	p.D268Y	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.D268Y	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	268	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCAGCCACTGACCAAGACGA	0.478			NA											40	128					3.66854e-30	6.31172e-30	0.007835	1	0
LARP1	23367	broad.mit.edu	37	5	154181956	154181956	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr5:154181956C>G	uc003lvp.2	+	11	2535	c.2106C>G	c.(2104-2106)ATC>ATG	p.I702M	LARP1_uc003lvo.2_Missense_Mutation_p.I625M|LARP1_uc010jie.1_Missense_Mutation_p.I497M	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	702							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ATTCCCAGATCAAGGTGAGGC	0.433			NA											4	71					0	0	0.009096	0	0
ZNF454	285676	broad.mit.edu	37	5	178392687	178392687	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr5:178392687G>T	uc003mjo.1	+	5	1553	c.1282G>T	c.(1282-1284)GCC>TCC	p.A428S	ZNF454_uc010jkz.1_Missense_Mutation_p.A428S	NM_182594	NP_872400	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	428	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		ATCAGCACTAGCCCAACATCA	0.423			NA											16	86					2.32078e-09	2.89575e-09	0.003163	1	0
PHACTR1	221692	broad.mit.edu	37	6	13283719	13283719	+	Silent	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr6:13283719C>T	uc010jpc.2	+	13	1907	c.1575C>T	c.(1573-1575)TAC>TAT	p.Y525Y	PHACTR1_uc003nah.1_Silent_p.Y525Y|TBC1D7_uc003naj.2_Intron|TBC1D7_uc011dis.1_Intron|uc003nak.1_Intron	NM_030948	NP_112210	Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	525						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			TCAGTGACTACGTGGAGGTGG	0.592			NA											27	143					0	0	0.008361	0	0
KIF13A	63971	broad.mit.edu	37	6	17849677	17849677	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr6:17849677G>T	uc003ncg.3	-	9	866	c.761C>A	c.(760-762)GCG>GAG	p.A254E	KIF13A_uc003ncf.2_Missense_Mutation_p.A254E|KIF13A_uc003nch.3_Missense_Mutation_p.A254E|KIF13A_uc003nci.3_Missense_Mutation_p.A254E	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	254	Kinesin-motor.				cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TTCGCTACCCGCCAGGTCTAC	0.458			NA											9	43					2.17888e-05	2.47356e-05	0.006214	1	0
SLC17A2	10246	broad.mit.edu	37	6	25921560	25921560	+	Silent	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr6:25921560G>T	uc011dkb.1	-	3	404	c.321C>A	c.(319-321)ATC>ATA	p.I107I	SLC17A2_uc011dkc.1_Silent_p.I107I|SLC17A2_uc003nfl.2_Silent_p.I107I			O00624	NPT3_HUMAN	SubName: Full=Solute carrier family 17 (Sodium phosphate), member 2, isoform CRA_b; SubName: Full=Putative uncharacterized protein SLC17A2;	107	Helical; (Potential).				phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			ovary(1)	1						ATCCACTTGGGATCAGAGTCA	0.448			NA											41	69					4.16155e-14	5.85151e-14	0.00874	1	0
TRIM27	5987	broad.mit.edu	37	6	28872311	28872311	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr6:28872311C>A	uc003nlr.2	-	8	1437	c.1078G>T	c.(1078-1080)GTC>TTC	p.V360F	TRIM27_uc003nls.2_Intron|TRIM27_uc003nlt.1_3'UTR	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	360	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						GAGCCCAAGACACAGGGAAAC	0.537			NA	T	RET	papillary thyroid								26	55					2.47511e-08	2.99391e-08	0.008361	1	0
BTNL2	56244	broad.mit.edu	37	6	32370728	32370728	+	Silent	SNP	C	C	A	rs79379254		TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr6:32370728C>A	uc003obg.1	-	3	693	c.693G>T	c.(691-693)TCG>TCT	p.S231S	BTNL2_uc010jty.1_Intron|BTNL2_uc010jtz.1_Intron|BTNL2_uc010jua.1_Intron	NM_019602	NP_062548	Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2	231	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						GGCTGATGACCGACCCCTTCT	0.582			NA											13	22					1.49906e-05	1.7088e-05	0.00245	1	0
HLA-DQB2	3120	broad.mit.edu	37	6	32726670	32726670	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr6:32726670T>G	uc003oby.3	-	3	686	c.603A>C	c.(601-603)CAA>CAC	p.Q201H	HLA-DQB2_uc003obz.2_Missense_Mutation_p.Q201H	NR_003937		Q5SR06	Q5SR06_HUMAN	SubName: Full=Major histocompatibility complex, class II, DQ beta 2; SubName: Full=Putative uncharacterized protein ENSP00000372579;	201					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex					0						GGTGCTCCACTTGGCAGGTGT	0.557			NA											4	51					0	0	0.001168	0	0
LPA	4018	broad.mit.edu	37	6	161071502	161071502	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr6:161071502T>G	uc003qtl.2	-	3	197	c.77A>C	c.(76-78)CAG>CCG	p.Q26P		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	2534	Kringle 23.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GTAGCAATCCTGGACCACATG	0.433			NA											35	78					0	0	0.003755	0	0
COL28A1	340267	broad.mit.edu	37	7	7477083	7477083	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:7477083C>T	uc003src.1	-	22	1850	c.1733G>A	c.(1732-1734)GGC>GAC	p.G578D	COL28A1_uc011jxe.1_Missense_Mutation_p.G261D|COL28A1_uc003srd.2_Missense_Mutation_p.G133D|COL28A1_uc003sre.1_5'UTR	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	578	Collagen-like 5.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		GCCCATAATGCCCGGTTCACC	0.313			NA											19	23					0	0	0.00333	0	0
COL28A1	340267	broad.mit.edu	37	7	7477086	7477086	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:7477086G>A	uc003src.1	-	22	1847	c.1730C>T	c.(1729-1731)CCG>CTG	p.P577L	COL28A1_uc011jxe.1_Missense_Mutation_p.P260L|COL28A1_uc003srd.2_Missense_Mutation_p.P132L|COL28A1_uc003sre.1_5'UTR	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	577	Collagen-like 5.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		CATAATGCCCGGTTCACCCTT	0.308			NA											18	23					0	0	0.00278	0	0
ABCB5	340273	broad.mit.edu	37	7	20778656	20778656	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:20778656T>A	uc003suw.3	+	15	2129	c.1583T>A	c.(1582-1584)GTT>GAT	p.V528D	ABCB5_uc010kuh.2_Missense_Mutation_p.V973D	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	528	Helical; (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						GAAACGCTCGTTTTGGCTCCT	0.423			NA											16	22					0	0	0.008871	0	0
BMPER	168667	broad.mit.edu	37	7	34118587	34118587	+	Silent	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:34118587G>A	uc011kap.1	+	12	1311	c.1197G>A	c.(1195-1197)TCG>TCA	p.S399S		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	399	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						CCCCTGCCTCGCCCTTCCAGG	0.582			NA											48	292					0	0	0.01441	0	0
URGCP	55665	broad.mit.edu	37	7	43917045	43917045	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:43917045G>A	uc003tiw.2	-	6	2074	c.2017C>T	c.(2017-2019)CGC>TGC	p.R673C	URGCP_uc003tiu.2_Missense_Mutation_p.R630C|URGCP_uc003tiv.2_Missense_Mutation_p.R598C|URGCP_uc003tix.2_Missense_Mutation_p.R664C|URGCP_uc003tiy.2_Missense_Mutation_p.R630C|URGCP_uc003tiz.2_Missense_Mutation_p.R630C|URGCP_uc011kbj.1_Missense_Mutation_p.R630C	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	673					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						GTGACCCAGCGGACGGGCATG	0.647			NA											33	63					0	0	0.003755	0	0
EGFR	1956	broad.mit.edu	37	7	55249071	55249071	+	Missense_Mutation	SNP	C	C	T	rs121434569		TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:55249071C>T	uc003tqk.2	+	20	2615	c.2369C>T	c.(2368-2370)ACG>ATG	p.T790M	EGFR_uc010kzg.1_Missense_Mutation_p.T745M|EGFR_uc011kco.1_Missense_Mutation_p.T737M|uc003tqo.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	790	Cytoplasmic (Potential).|ATP.|Protein kinase.		T -> M (found in a lung cancer sample; increased kinase activity).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.T790M(332)|p.I789_L792del(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAGCTCATCACGCAGCTCATG	0.602		T790M(NCIH1975_LUNG)	8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			109	100					0	0	0.01441	0	0
EGFR	1956	broad.mit.edu	37	7	55259515	55259515	+	Missense_Mutation	SNP	T	T	G	rs121434568		TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:55259515T>G	uc003tqk.2	+	21	2819	c.2573T>G	c.(2572-2574)CTG>CGG	p.L858R	EGFR_uc010kzg.1_Missense_Mutation_p.L813R|EGFR_uc011kco.1_Missense_Mutation_p.L805R|uc003tqo.2_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	858	Cytoplasmic (Potential).|Protein kinase.		L -> R (found in a lung cancer sample; somatic mutation; constitutively activated enzyme with strongly increased kinase activity).|L -> M (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L858R(3429)|p.L858L(4)|p.L858M(4)|p.L858Q(3)|p.L858A(2)|p.L858W(1)|p.L858P(1)|p.L858K(1)|p.L858G(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GATTTTGGGCTGGCCAAACTG	0.537		L858R(NCIH1975_LUNG)	8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			98	137					0	0	0.01441	0	0
ZNF680	340252	broad.mit.edu	37	7	63982254	63982254	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:63982254G>A	uc003tta.2	-	4	1051	c.878C>T	c.(877-879)CCT>CTT	p.P293L	ZNF680_uc010kzr.2_Missense_Mutation_p.P220L	NM_178558	NP_848653	Q8NEM1	ZN680_HUMAN	zinc finger protein 680 isoform 1	293					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.118)|all_lung(88;0.243)				ACATTTGTAAGGTTTGTCTCC	0.348			NA											4	39					0	0	0.009096	0	0
FKBP6	8468	broad.mit.edu	37	7	72744332	72744332	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:72744332G>T	uc003tya.2	+	4	577	c.445G>T	c.(445-447)GAC>TAC	p.D149Y	FKBP6_uc003twz.2_Intron|FKBP6_uc011kew.1_Missense_Mutation_p.D144Y|FKBP6_uc010lbe.1_RNA|TRIM50_uc003txy.1_5'Flank|TRIM50_uc003txz.1_5'Flank	NM_003602	NP_003593	O75344	FKBP6_HUMAN	FK506 binding protein 6 isoform a	149					protein folding	membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				TGCTGAGTCAGACAAGTTTTG	0.493			NA											46	47					1.08114e-33	1.8835e-33	0.01441	1	0
BCL7B	9275	broad.mit.edu	37	7	72952325	72952325	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:72952325G>A	uc003tyf.1	-	5	571	c.455C>T	c.(454-456)TCG>TTG	p.S152L	BCL7B_uc010lbf.1_RNA|BCL7B_uc003tye.1_RNA|BCL7B_uc003tyg.1_Missense_Mutation_p.S95L	NM_001707	NP_001698	Q9BQE9	BCL7B_HUMAN	B-cell CLL/lymphoma 7B	152							actin binding			ovary(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				AGCAACTTCCGAGGAGGGCAG	0.537			NA											5	188					0	0	0.001168	0	0
RUNDC3B	154661	broad.mit.edu	37	7	87436744	87436744	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:87436744C>T	uc003ujb.2	+	10	1475	c.1064C>T	c.(1063-1065)ACC>ATC	p.T355I	RUNDC3B_uc011khd.1_Missense_Mutation_p.T338I|RUNDC3B_uc011khe.1_Missense_Mutation_p.T338I|RUNDC3B_uc003ujc.2_Intron|RUNDC3B_uc003ujd.2_Intron	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	355										skin(1)	1	Esophageal squamous(14;0.00164)					GCCCATCTCACCAACCAGTGG	0.413			NA											18	138					0	0	0.010504	0	0
ADAM22	53616	broad.mit.edu	37	7	87780637	87780637	+	Splice_Site	SNP	T	T	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:87780637T>G	uc003ujn.2	+	20	1760	c.1681_splice	c.e20+2	p.K561_splice	ADAM22_uc003ujk.1_Splice_Site_p.K561_splice|ADAM22_uc003ujl.1_Splice_Site_p.K561_splice|ADAM22_uc003ujm.2_Splice_Site_p.K561_splice|ADAM22_uc003ujo.2_Splice_Site_p.K561_splice|ADAM22_uc003ujp.1_Splice_Site_p.K613_splice	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1						cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			GGGGGCAAAGTAAGTAAATAG	0.403			NA											19	124					0	0	0.012319	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965549	88965549	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:88965549G>T	uc011khi.1	+	4	3791	c.3253G>T	c.(3253-3255)GTG>TTG	p.V1085L		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1085						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			ATATACTGGTGTGACTGATTC	0.348			NA								HNSCC(36;0.09)			48	65					5.57489e-27	9.30268e-27	0.01441	1	0
CCDC132	55610	broad.mit.edu	37	7	92979331	92979331	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:92979331G>T	uc003umo.2	+	25	2577	c.2449G>T	c.(2449-2451)GAT>TAT	p.D817Y	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.D787Y|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Missense_Mutation_p.D537Y	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	817											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			CATATATGTAGATGCACTATT	0.378			NA											10	86					0.000442599	0.000477043	0.006214	1	0
C7orf51	222950	broad.mit.edu	37	7	100086913	100086913	+	Silent	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:100086913G>T	uc003uvd.1	+	4	1728	c.1569G>T	c.(1567-1569)GGG>GGT	p.G523G	C7orf51_uc003uve.1_Silent_p.G305G	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	523										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CAGCAGCTGGGGTCCTCCACC	0.692			NA											11	17					4.36969e-10	5.5779e-10	0.001855	1	0
MUC17	140453	broad.mit.edu	37	7	100675478	100675478	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:100675478G>C	uc003uxp.1	+	3	834	c.781G>C	c.(781-783)GAA>CAA	p.E261Q	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	261	Extracellular (Potential).|59 X approximate tandem repeats.|2.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TACAACTGCTGAAGGTCCCAG	0.512			NA											10	278					0	0	0.00245	0	0
MUC17	140453	broad.mit.edu	37	7	100677522	100677522	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:100677522G>C	uc003uxp.1	+	3	2878	c.2825G>C	c.(2824-2826)AGA>ACA	p.R942T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	942	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|13.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCTGAGGCTAGAACACTTTCA	0.512			NA											33	621					0	0	0.013726	0	0
RELN	5649	broad.mit.edu	37	7	103159823	103159823	+	Silent	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:103159823G>T	uc003vca.2	-	49	7969	c.7809C>A	c.(7807-7809)GGC>GGA	p.G2603G	RELN_uc010liz.2_Silent_p.G2603G	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2603	BNR 12.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCCAGGTAATGCCTCCATTGA	0.413	NSCLC(146;835 1944 15585 22231 52158)		NA											64	81					4.46356e-37	7.92568e-37	0.01441	1	0
RELN	5649	broad.mit.edu	37	7	103205942	103205942	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:103205942G>T	uc003vca.2	-	34	5153	c.4993C>A	c.(4993-4995)CAG>AAG	p.Q1665K	RELN_uc010liz.2_Missense_Mutation_p.Q1665K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1665					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATTTCAAACTGCAAAAAGGTA	0.433	NSCLC(146;835 1944 15585 22231 52158)		NA											10	54					2.23348e-06	2.61044e-06	0.004007	1	0
ORC5L	5001	broad.mit.edu	37	7	103844634	103844634	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:103844634T>C	uc003vcb.2	-	2	232	c.121A>G	c.(121-123)AGT>GGT	p.S41G	ORC5L_uc011klp.1_5'UTR|ORC5L_uc003vcc.2_Missense_Mutation_p.S41G|ORC5L_uc003vcd.2_Missense_Mutation_p.S41G	NM_002553	NP_002544	O43913	ORC5_HUMAN	origin recognition complex subunit 5 isoform 1	41	ATP (Potential).				cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	cytoplasm|nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|identical protein binding				0						GTCTTTCCACTAGCAGTATGT	0.294			NA											23	15					0	0	0.005443	0	0
CPA2	1358	broad.mit.edu	37	7	129909536	129909536	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:129909536C>G	uc003vpq.2	+	3	200	c.181C>G	c.(181-183)CCA>GCA	p.P61A	CPA2_uc011kpc.1_Missense_Mutation_p.P61A	NM_001869	NP_001860	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic) precursor	61					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					ACCCACCACCCCAGGGGAGAC	0.498			NA											67	81					0	0	0.01441	0	0
GIMAP8	155038	broad.mit.edu	37	7	150164352	150164352	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:150164352T>C	uc003whj.2	+	2	896	c.566T>C	c.(565-567)GTT>GCT	p.V189A		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	189						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CTTCGCAAGGTTGAGTCTTTG	0.428			NA											30	228					0	0	0.012213	0	0
PRKAG2	51422	broad.mit.edu	37	7	151372540	151372540	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:151372540A>T	uc003wkk.2	-	4	1261	c.650T>A	c.(649-651)CTG>CAG	p.L217Q	PRKAG2_uc011kvl.1_Missense_Mutation_p.L93Q|PRKAG2_uc003wkj.2_Missense_Mutation_p.L173Q|PRKAG2_uc010lqe.1_RNA|PRKAG2_uc003wkm.1_Missense_Mutation_p.L217Q	NM_016203	NP_057287	Q9UGJ0	AAKG2_HUMAN	AMP-activated protein kinase gamma2 subunit	217					ATP biosynthetic process|carnitine shuttle|cell cycle arrest|fatty acid biosynthetic process|glycogen metabolic process|insulin receptor signaling pathway|intracellular protein kinase cascade|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein kinase activity|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation|regulation of glucose import|regulation of glycolysis|sterol biosynthetic process	AMP-activated protein kinase complex|cytosol|nucleoplasm	ADP binding|ATP binding|cAMP-dependent protein kinase inhibitor activity|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|protein kinase activator activity|protein kinase binding			breast(1)|kidney(1)	2	all_neural(206;0.187)	all_hematologic(28;0.0605)	OV - Ovarian serous cystadenocarcinoma(82;0.00252)	UCEC - Uterine corpus endometrioid carcinoma (81;0.185)		CGGTGATGCCAGTGGAGGCCT	0.622			NA											34	50					0	0	0.005524	0	0
CSMD1	64478	broad.mit.edu	37	8	2944669	2944669	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr8:2944669C>G	uc011kwk.1	-	49	7817	c.7427G>C	c.(7426-7428)CGA>CCA	p.R2476P	CSMD1_uc011kwj.1_Missense_Mutation_p.R1805P|CSMD1_uc010lrg.2_Missense_Mutation_p.R544P	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2476	Sushi 14.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AAGTGGGTTTCGTCTACAGGT	0.507			NA											14	47					0	0	0.00245	0	0
CSMD1	64478	broad.mit.edu	37	8	3265422	3265422	+	Silent	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr8:3265422G>T	uc011kwk.1	-	14	2463	c.2073C>A	c.(2071-2073)ACC>ACA	p.T691T	CSMD1_uc011kwj.1_Silent_p.T83T	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	691	Extracellular (Potential).|CUB 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CGTACTTACTGGTGTAAGTGA	0.438			NA											4	14					2.56e-06	2.9795e-06	0.009096	1	0
EXTL3	2137	broad.mit.edu	37	8	28600642	28600642	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr8:28600642A>G	uc003xgz.1	+	6	3054	c.2461A>G	c.(2461-2463)ATC>GTC	p.I821V		NM_001440	NP_001431	O43909	EXTL3_HUMAN	exostoses-like 3	821	Lumenal (Potential).					integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			skin(2)	2		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		GCCCCAGGCCATCCGGGACAT	0.493			NA											83	271					0	0	0.01441	0	0
TEX15	56154	broad.mit.edu	37	8	30703484	30703484	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr8:30703484A>T	uc003xil.2	-	1	3050	c.3050T>A	c.(3049-3051)CTT>CAT	p.L1017H		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1017										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TTTAGTTATAAGCTGCAAAGA	0.338			NA											29	140					0	0	0.007291	0	0
MYST3	7994	broad.mit.edu	37	8	41791382	41791382	+	Silent	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr8:41791382C>A	uc010lxb.2	-	18	4900	c.4356G>T	c.(4354-4356)GCG>GCT	p.A1452A	MYST3_uc010lxc.2_Silent_p.A1452A|MYST3_uc003xon.3_Silent_p.A1452A	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1452					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			GGGTCTGACACGCCGCAAGAG	0.532			NA											25	148					3.11337e-16	4.53897e-16	0.013726	1	0
KCNB2	9312	broad.mit.edu	37	8	73480430	73480430	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr8:73480430G>T	uc003xzb.2	+	2	1049	c.461G>T	c.(460-462)CGA>CTA	p.R154L		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	154	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			GAACTGAGGCGAGAGGCAGAG	0.453			NA											36	185					6.5261e-18	9.71898e-18	0.00874	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88885425	88885425	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr8:88885425C>A	uc003ydz.2	-	1	872	c.775G>T	c.(775-777)GGC>TGC	p.G259C		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	259										ovary(1)	1						CACCCGCTGCCTTGATTTCCA	0.507			NA											24	80					5.35356e-11	7.0616e-11	0.00278	1	0
MTERFD1	51001	broad.mit.edu	37	8	97270732	97270732	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr8:97270732T>A	uc003yhs.1	-	2	265	c.187A>T	c.(187-189)ACT>TCT	p.T63S	MTERFD1_uc003yhr.1_5'Flank|MTERFD1_uc010mbd.1_Missense_Mutation_p.T63S	NM_015942	NP_057026	Q96E29	MTER1_HUMAN	MTERF domain containing 1 precursor	63					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion	transcription regulatory region DNA binding			ovary(1)	1	Breast(36;5.16e-05)					AAGGAGGAAGTCCTGTAAGTC	0.433			NA											23	103					0	0	0.00278	0	0
EIF2C2	27161	broad.mit.edu	37	8	141595310	141595310	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr8:141595310C>G	uc003yvn.2	-	2	163	c.123G>C	c.(121-123)CAG>CAC	p.Q41H	EIF2C2_uc010men.2_Intron|EIF2C2_uc010meo.2_Missense_Mutation_p.Q41H	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	41					mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			AGAAATTGGCCTGTAATTTGA	0.498			NA											27	88					0	0	0.005443	0	0
INSL6	11172	broad.mit.edu	37	9	5185531	5185531	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr9:5185531G>T	uc003zix.2	-	1	88	c.72C>A	c.(70-72)AGC>AGA	p.S24R		NM_007179	NP_009110	Q9Y581	INSL6_HUMAN	insulin-like 6 precursor	24						extracellular region	hormone activity				0	all_hematologic(13;0.137)	Breast(48;0.147)|Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0128)|Lung(218;0.145)		TGCTGATGTCGCTCAGTTCAC	0.587			NA											23	25					1.5548e-18	2.34065e-18	0.005443	1	0
KIAA1045	23349	broad.mit.edu	37	9	34977191	34977191	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr9:34977191C>A	uc003zvq.2	+	6	1139	c.961C>A	c.(961-963)CAC>AAC	p.H321N	KIAA1045_uc003zvr.2_Missense_Mutation_p.H321N	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	321							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			CCGGGCCCAGCACTCTTGGTT	0.637			NA											35	72					4.44401e-20	6.83884e-20	0.010771	1	0
CXorf22	170063	broad.mit.edu	37	X	35993959	35993959	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chrX:35993959G>T	uc004ddj.2	+	15	2701	c.2642G>T	c.(2641-2643)TGT>TTT	p.C881F	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	881										large_intestine(1)|lung(1)|ovary(1)	3						CGTCAGAATTGTTGTGCTCAG	0.383			NA											61	74					6.2918e-36	1.10306e-35	0.01441	1	0
RBM10	8241	broad.mit.edu	37	X	47034492	47034492	+	Splice_Site	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chrX:47034492G>T	uc004dhf.2	+	6	955	c.576_splice	c.e6+1	p.Q192_splice	RBM10_uc004dhe.1_Intron|RBM10_uc004dhg.2_Splice_Site_p.Q115_splice|RBM10_uc004dhh.2_Splice_Site_p.Q192_splice|RBM10_uc010nhq.2_Splice_Site_p.Q115_splice|RBM10_uc004dhi.2_Splice_Site_p.Q257_splice	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1						mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						AGCCAATCAGGTTGCTTTGCC	0.542	Melanoma(171;120 2705 19495 39241)		NA											24	20					1.08312e-15	1.56263e-15	0.009535	1	0
TSPYL2	64061	broad.mit.edu	37	X	53114870	53114870	+	Silent	SNP	A	A	C			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chrX:53114870A>C	uc004drw.2	+	6	1428	c.1296A>C	c.(1294-1296)GCA>GCC	p.A432A	TSPYL2_uc004drv.2_3'UTR|TSPYL2_uc004drx.1_Silent_p.A37A	NM_022117	NP_071400	Q9H2G4	TSYL2_HUMAN	TSPY-like 2	432					cell cycle|chromatin modification|negative regulation of cell cycle|negative regulation of cell growth|negative regulation of DNA replication|nucleosome assembly|regulation of protein kinase activity|regulation of signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|rDNA binding				0						ACTATTATGCAGTGGAAGACA	0.488			NA											31	43					0	0	0.013726	0	0
TCEAL2	140597	broad.mit.edu	37	X	101382384	101382384	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chrX:101382384G>T	uc004eip.2	+	3	801	c.582G>T	c.(580-582)ATG>ATT	p.M194I		NM_080390	NP_525129	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	194					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						TTTTGTGGATGCAAAGAAATT	0.463			NA											68	122					1.07941e-43	1.95423e-43	0.01441	1	0
GLRA4	441509	broad.mit.edu	37	X	102979534	102979534	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chrX:102979534G>T	uc011mse.1	-	3	626	c.205C>A	c.(205-207)CCA>ACA	p.P69T	GLRA4_uc010nou.2_Missense_Mutation_p.P69T	NM_001024452	NP_001019623	Q5JXX5	GLRA4_HUMAN	glycine receptor, alpha 4 precursor	69	Extracellular (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity				0						TTCACGGGTGGGCCTGAGGGT	0.582			NA											7	18					0.000157383	0.000175081	0.00308	1	0
DCAF12L2	340578	broad.mit.edu	37	X	125299021	125299021	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chrX:125299021G>T	uc004euk.1	-	1	914	c.887C>A	c.(886-888)TCC>TAC	p.S296Y		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	296	WD 3.									lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						CAGGAGCCTGGATAGTGTGCT	0.612			NA											46	82					4.48484e-38	8.06688e-38	0.01441	1	0
DCAF12L2	340578	broad.mit.edu	37	X	125299047	125299047	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chrX:125299047G>T	uc004euk.1	-	1	888	c.861C>A	c.(859-861)CAC>CAA	p.H287Q		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	287	WD 3.									lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						CTTTCCACAGGTGGAAGTAGC	0.617			NA											43	82					1.0331e-37	1.84624e-37	0.01441	1	0
PVRL4	81607	broad.mit.edu	37	1	161049685	161049685	+	Frame_Shift_Del	DEL	C	C	-			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr1:161049685delC	uc001fxo.2	-	2	433	c.134delG	c.(133-135)GGCfs	p.G45fs		NM_030916	NP_112178	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4 precursor	45	Ig-like V-type 1.|Extracellular (Potential).				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				ovary(2)	2	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			TGCGTCCTGGCCCAGCACCAC	0.677	NSCLC(76;1160 1387 14476 16172 29359)		NA											24	124	---	---	---	---	NA	NA	NA	NA	NA
ZNF521	25925	broad.mit.edu	37	18	22902131	22902131	+	Frame_Shift_Del	DEL	C	C	-	rs7235917		TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr18:22902131delC	uc002kvk.2	-	3	308	c.61delG	c.(61-63)GACfs	p.D21fs	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Frame_Shift_Del_p.D21fs|ZNF521_uc002kvl.2_5'UTR	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	21					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TCAGTCTTGTCTTCAAGTTTA	0.433			NA	T	PAX5	ALL								30	163	---	---	---	---	NA	NA	NA	NA	NA
GZMK	3003	broad.mit.edu	37	5	54320167	54320167	+	Frame_Shift_Del	DEL	C	C	-			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr5:54320167delC	uc003jpl.1	+	1	61	c.17delC	c.(16-18)TCCfs	p.S6fs		NM_002104	NP_002095	P49863	GRAK_HUMAN	granzyme K precursor	6					proteolysis	extracellular region	serine-type endopeptidase activity				0		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				AAGTTTTCTTCCTTTTCTCTG	0.318			NA											19	45	---	---	---	---	NA	NA	NA	NA	NA
OR2A5	393046	broad.mit.edu	37	7	143748258	143748258	+	Frame_Shift_Del	DEL	C	C	-			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chr7:143748258delC	uc011ktw.1	+	1	764	c.764delC	c.(763-765)GCCfs	p.A255fs		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	255	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					TTTGGCAGCGCCATTGTCATG	0.587			NA											138	152	---	---	---	---	NA	NA	NA	NA	NA
MAGEA3	4102	broad.mit.edu	37	X	151935379	151935379	+	Frame_Shift_Del	DEL	C	C	-			TCGA-49-4494-01A-01D-1265-08	TCGA-49-4494-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	136bc973-1908-4767-9b22-d43d522b7c71	417cd2e0-404a-4820-be10-b02d26fe89fd	g.chrX:151935379delC	uc004fgp.2	-	3	997	c.788delG	c.(787-789)GGCfs	p.G263fs		NM_005362	NP_005353	P43357	MAGA3_HUMAN	melanoma antigen family A, 3	263	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					AGGATCACTGCCGGGGACCTG	0.527			NA											39	92	---	---	---	---	NA	NA	NA	NA	NA
