Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CLCN6	1185	broad.mit.edu	37	1	11896114	11896114	+	Silent	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr1:11896114G>A	uc001ate.3	+	18	1997	c.1884G>A	c.(1882-1884)ACG>ACA	p.T628T	CLCN6_uc010oat.1_Silent_p.T344T|CLCN6_uc010oau.1_Silent_p.T606T	NM_001286	NP_001277	P51797	CLCN6_HUMAN	chloride channel 6 isoform ClC-6a	628	Cytoplasmic (By similarity).|CBS 1.				cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		TGCGCACCACGGTCCACCATG	0.582			NA											3	20					0	0	0.004672	0	0
C1orf173	127254	broad.mit.edu	37	1	75065513	75065513	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr1:75065513A>G	uc001dgg.2	-	11	1811	c.1592T>C	c.(1591-1593)TTG>TCG	p.L531S	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.L325S	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	531	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TTTATCATCCAAAGGTGACTG	0.388			NA											6	176					0	0	0.001984	0	0
S1PR1	1901	broad.mit.edu	37	1	101705215	101705215	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr1:101705215C>A	uc001dud.2	+	2	1189	c.675C>A	c.(673-675)TAC>TAA	p.Y225*	S1PR1_uc009weg.2_Nonsense_Mutation_p.Y225*	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	225	Cytoplasmic (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						GCAGAATCTACTCCTTGGTCA	0.567			NA											15	61					4.7546e-09	6.85548e-09	0.004007	1	0
LCE1F	353137	broad.mit.edu	37	1	152748899	152748899	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr1:152748899C>A	uc010pdv.1	+	1	52	c.52C>A	c.(52-54)CCC>ACC	p.P18T		NM_178354	NP_848131	Q5T754	LCE1F_HUMAN	late cornified envelope 1F	18	Pro-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			caagtgcactcccaagtgccc	0.368			NA											17	72					8.34094e-07	1.12421e-06	0.008871	1	0
LCE1F	353137	broad.mit.edu	37	1	152749165	152749165	+	Silent	SNP	C	C	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr1:152749165C>T	uc010pdv.1	+	1	318	c.318C>T	c.(316-318)TGC>TGT	p.C106C		NM_178354	NP_848131	Q5T754	LCE1F_HUMAN	late cornified envelope 1F	106					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAGCTGCTGCGGAGGGGGCA	0.627			NA											8	40					0	0	0.00245	0	0
HCN3	57657	broad.mit.edu	37	1	155257693	155257693	+	Silent	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr1:155257693G>T	uc001fjz.1	+	8	1772	c.1764G>T	c.(1762-1764)CGG>CGT	p.R588R	RAG1AP1_uc010pey.1_Intron|HCN3_uc010pfz.1_Silent_p.R283R	NM_020897	NP_065948	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic	588	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)|breast(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TTCGGGGTCGGGCCCCGAGCA	0.617			NA											10	53					0.000673444	0.000787802	0.008291	1	0
ASH1L	55870	broad.mit.edu	37	1	155408569	155408569	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr1:155408569G>A	uc009wqq.2	-	5	5857	c.5377C>T	c.(5377-5379)CAT>TAT	p.H1793Y	ASH1L_uc001fkt.2_Missense_Mutation_p.H1793Y	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	1793					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TTGATATGATGGGGGGAACAG	0.443			NA											13	157					0	0	0.001855	0	0
UBQLN4	56893	broad.mit.edu	37	1	156020169	156020169	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr1:156020169C>T	uc001fna.2	-	4	678	c.654G>A	c.(652-654)ATG>ATA	p.M218I	UBQLN4_uc010pgx.1_Missense_Mutation_p.M198I	NM_020131	NP_064516	Q9NRR5	UBQL4_HUMAN	ataxin-1 ubiquitin-like interacting protein	218						cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			pancreas(1)|skin(1)	2	Hepatocellular(266;0.133)|all_neural(408;0.195)					TGGCCATAATCATGTGACGCA	0.522			NA											47	112					0	0	0.00361	0	0
SPTA1	6708	broad.mit.edu	37	1	158632684	158632684	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr1:158632684G>T	uc001fst.1	-	17	2471	c.2272C>A	c.(2272-2274)CAT>AAT	p.H758N		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	758	Spectrin 8.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GAATCAGGATGGCCTATTTCT	0.438			NA											11	71					3.86212e-05	4.78903e-05	0.008291	1	0
SEC16B	89866	broad.mit.edu	37	1	177930770	177930770	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr1:177930770G>A	uc001gli.1	-	6	832	c.742C>T	c.(742-744)CGG>TGG	p.R248W	SEC16B_uc001glk.1_5'UTR|SEC16B_uc001glh.1_5'Flank|SEC16B_uc009wwz.1_5'UTR|SEC16B_uc001glj.1_Missense_Mutation_p.R248W|SEC16B_uc001gll.3_Missense_Mutation_p.R248W	NM_033127	NP_149118	Q96JE7	SC16B_HUMAN	leucine zipper transcription regulator 2	248					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				ovary(3)|central_nervous_system(1)	4						GGATCATCCCGCTCCGGGGCA	0.537			NA											7	76					0	0	0.001984	0	0
TDRD5	163589	broad.mit.edu	37	1	179604812	179604812	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr1:179604812C>A	uc001gnf.1	+	9	1560	c.1310C>A	c.(1309-1311)ACA>AAA	p.T437K	TDRD5_uc010pnp.1_Missense_Mutation_p.T437K|TDRD5_uc001gnh.1_5'UTR	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	437					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						CAAGTAGAAACAAACAAATCA	0.338			NA											8	29					5.4927e-09	7.85879e-09	0.004482	1	0
NFASC	23114	broad.mit.edu	37	1	204937421	204937421	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr1:204937421G>A	uc001hbj.2	+	9	1079	c.751G>A	c.(751-753)GGC>AGC	p.G251S	NFASC_uc001hbh.2_Missense_Mutation_p.G251S|NFASC_uc010pqz.1_Missense_Mutation_p.G245S|NFASC_uc010pra.1_Missense_Mutation_p.G262S|NFASC_uc001hbi.2_Missense_Mutation_p.G262S|NFASC_uc009xbg.1_Missense_Mutation_p.G335S|NFASC_uc010prb.1_Missense_Mutation_p.G262S|NFASC_uc010prc.1_5'UTR|NFASC_uc001hbk.1_Missense_Mutation_p.G72S	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	251	Extracellular (Potential).|Ig-like C2-type 3.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GTATCCCCAGGGCACCGCGAG	0.582			NA											10	83					0	0	0.008291	0	0
RYR2	6262	broad.mit.edu	37	1	237774102	237774102	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr1:237774102A>G	uc001hyl.1	+	36	4844	c.4724A>G	c.(4723-4725)CAC>CGC	p.H1575R		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1575	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAGAGTGAGCACAAGAACCCC	0.532			NA											3	14					0	0	0.000248	0	0
PLD5	200150	broad.mit.edu	37	1	242264084	242264084	+	Nonsense_Mutation	SNP	T	T	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr1:242264084T>A	uc001hzn.1	-	9	1367	c.1240A>T	c.(1240-1242)AAA>TAA	p.K414*	PLD5_uc001hzl.3_Nonsense_Mutation_p.K352*|PLD5_uc001hzm.3_Nonsense_Mutation_p.K204*|PLD5_uc001hzo.1_Nonsense_Mutation_p.K322*			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	414						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			TCAAAAAATTTCTGTAAGAAA	0.373			NA											18	77					0	0	0.007413	0	0
OR2T8	343172	broad.mit.edu	37	1	248084381	248084381	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr1:248084381C>T	uc010pzc.1	+	1	62	c.62C>T	c.(61-63)GCC>GTC	p.A21V		NM_001005522	NP_001005522	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CACACCAGAGCCCACCAAGTC	0.448			NA											11	161					0	0	0.000978	0	0
ZWINT	11130	broad.mit.edu	37	10	58118343	58118343	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr10:58118343C>A	uc001jjx.1	-	7	803	c.766G>T	c.(766-768)GGG>TGG	p.G256W	ZWINT_uc001jjy.1_Missense_Mutation_p.G209W|ZWINT_uc001jka.1_Missense_Mutation_p.G256W|ZWINT_uc009xoy.1_RNA	NM_007057	NP_008988	O95229	ZWINT_HUMAN	ZW10 interactor isoform a	256					cell division|establishment of localization in cell|mitotic cell cycle checkpoint|mitotic prometaphase|mitotic sister chromatid segregation|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytosol|nucleus	protein N-terminus binding				0						GGGTCTCTCCCCATGGTGTCT	0.567			NA											29	96					9.17885e-22	1.51085e-21	0.003271	1	0
OPALIN	93377	broad.mit.edu	37	10	98105750	98105750	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr10:98105750A>G	uc001kmj.2	-	6	813	c.374T>C	c.(373-375)ATG>ACG	p.M125T	OPALIN_uc010qor.1_Missense_Mutation_p.M115T|OPALIN_uc001kmi.2_Missense_Mutation_p.M115T|OPALIN_uc001kmk.2_Missense_Mutation_p.M102T|OPALIN_uc010qos.1_RNA	NM_033207	NP_149984	Q96PE5	OPALI_HUMAN	transmembrane protein 10 isoform a	125						Golgi apparatus|integral to membrane|plasma membrane					0						CCTTCTTTCCATTTCTATAGT	0.517			NA											38	104					0	0	0.00623	0	0
SORCS3	22986	broad.mit.edu	37	10	106937932	106937932	+	Splice_Site	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr10:106937932G>T	uc001kyi.1	+	14	2236	c.2009_splice	c.e14+1	p.T670_splice	SORCS3_uc010qqz.1_Intron	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor							integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ACATCATGACGTGAGTACTTC	0.498	NSCLC(116;1497 1690 7108 13108 14106)		NA											3	45					0.00024832	0.000297984	0.000248	1	0
SHOC2	8036	broad.mit.edu	37	10	112764460	112764460	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr10:112764460A>G	uc001kzl.3	+	5	1418	c.1069A>G	c.(1069-1071)ATC>GTC	p.I357V	SHOC2_uc009xxx.2_Missense_Mutation_p.I357V|SHOC2_uc010qrg.1_5'UTR|SHOC2_uc001kzn.2_Missense_Mutation_p.I311V	NM_007373	NP_031399	Q9UQ13	SHOC2_HUMAN	soc-2 suppressor of clear homolog	357	LRR 12.				fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			ovary(1)|skin(1)	2				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)		GTTTTCTACCATCTATTCCCT	0.368			NA											14	65					0	0	0.00245	0	0
ADRA2A	150	broad.mit.edu	37	10	112838174	112838174	+	Silent	SNP	C	C	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr10:112838174C>T	uc001kzo.2	+	1	1385	c.420C>T	c.(418-420)TGC>TGT	p.C140C		NM_000681	NP_000672	P08913	ADA2A_HUMAN	alpha-2A-adrenergic receptor	125	Helical; Name=3; (By similarity).				actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding				0		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	TGCACCTGTGCGCCATCAGCC	0.612	Esophageal Squamous(173;605 2658 7278 49362)		NA											3	32					0	0	0.004672	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116060424	116060424	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr10:116060424G>A	uc001lbn.2	-	14	1869	c.1568C>T	c.(1567-1569)CCT>CTT	p.P523L	AFAP1L2_uc001lbo.2_Missense_Mutation_p.P523L|AFAP1L2_uc010qse.1_Missense_Mutation_p.P576L|AFAP1L2_uc001lbp.2_Missense_Mutation_p.P551L|AFAP1L2_uc001lbr.1_Missense_Mutation_p.P523L|AFAP1L2_uc001lbm.2_Intron|AFAP1L2_uc010qsd.1_Missense_Mutation_p.P89L|AFAP1L2_uc001lbq.1_Missense_Mutation_p.P45L	NM_001001936	NP_001001936	Q8N4X5	AF1L2_HUMAN	KIAA1914 protein isoform 1	523					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			ovary(1)|breast(1)	2		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		ATCTGCAACAGGGGTGGCTTC	0.582			NA											8	72					0	0	0.008291	0	0
DMBT1	1755	broad.mit.edu	37	10	124358327	124358327	+	Silent	SNP	A	A	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr10:124358327A>C	uc001lgk.1	+	26	3100	c.2994A>C	c.(2992-2994)GGA>GGC	p.G998G	DMBT1_uc001lgl.1_Silent_p.G988G|DMBT1_uc001lgm.1_Silent_p.G499G|DMBT1_uc009xzz.1_Silent_p.G998G|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yab.1_5'UTR	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	998	SRCR 8.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGGTGAATGGAGGTGACAGGT	0.537	Ovarian(182;93 2026 18125 22222 38972)		NA											32	271					0	0	0.002852	0	0
OR2AG1	144125	broad.mit.edu	37	11	6806454	6806454	+	Silent	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr11:6806454G>T	uc001mer.1	+	1	186	c.186G>T	c.(184-186)CTG>CTT	p.L62L		NM_001004489	NP_001004489	Q9H205	O2AG1_HUMAN	olfactory receptor, family 2, subfamily AG,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.19e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TGTACCTCCTGCTTGGGCAGC	0.532			NA											27	131					1.06801e-11	1.62828e-11	0.001786	1	0
NLRP14	338323	broad.mit.edu	37	11	7063760	7063760	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr11:7063760T>A	uc001mfb.1	+	4	826	c.503T>A	c.(502-504)GTG>GAG	p.V168E		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	168					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TTGTTCGATGTGGATGTCAAA	0.468			NA											19	88					0	0	0.001523	0	0
OR5M3	219482	broad.mit.edu	37	11	56237132	56237132	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr11:56237132G>T	uc010rjk.1	-	1	842	c.842C>A	c.(841-843)CCC>CAC	p.P281H		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	281	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ATTCAACATGGGGATCACTGT	0.418			NA											9	32					5.50884e-06	7.2158e-06	0.001368	1	0
ODZ4	26011	broad.mit.edu	37	11	78412983	78412983	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr11:78412983G>A	uc001ozl.3	-	28	5138	c.4675C>T	c.(4675-4677)CGA>TGA	p.R1559*	ODZ4_uc009yvb.1_Nonsense_Mutation_p.R143*	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1559	NHL 5.|Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						AACCGAATTCGGATGTTCCCA	0.488			NA											4	91					0	0	0.000248	0	0
FAT3	120114	broad.mit.edu	37	11	92086791	92086791	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr11:92086791G>C	uc001pdj.3	+	1	1530	c.1513G>C	c.(1513-1515)GGG>CGG	p.G505R		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	505	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGGAGAAAATGGGTACATCAC	0.383			NA								TCGA Ovarian(4;0.039)			15	33					0	0	0.00245	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103006491	103006491	+	Silent	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr11:103006491G>T	uc001pho.2	+	17	2532	c.2388G>T	c.(2386-2388)CGG>CGT	p.R796R	DYNC2H1_uc001phn.1_Silent_p.R796R|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	796	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AAGAAATCCGGGCTAAATATT	0.323			NA											9	29					3.09899e-07	4.26971e-07	0.004482	1	0
NCAM1	4684	broad.mit.edu	37	11	113076778	113076778	+	Silent	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr11:113076778C>A	uc009yyq.1	+	5	844	c.150C>A	c.(148-150)GTC>GTA	p.V50V	NCAM1_uc001pno.2_Silent_p.V50V	NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	168	Ig-like C2-type 2.|Extracellular (Potential).				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		GATTCATAGTCCTGTCCAACA	0.502			NA											23	47					7.88262e-20	1.28611e-19	0.00333	1	0
APOA5	116519	broad.mit.edu	37	11	116660968	116660968	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr11:116660968G>T	uc001ppr.2	-	3	985	c.977C>A	c.(976-978)CCA>CAA	p.P326Q	ZNF259_uc001ppp.2_5'Flank|ZNF259_uc009yzd.2_5'Flank|ZNF259_uc001ppq.2_5'Flank|APOA5_uc009yze.2_Missense_Mutation_p.P326Q|APOA5_uc009yzf.2_Missense_Mutation_p.P326Q|APOA5_uc009yzg.2_Missense_Mutation_p.P352Q	NM_052968	NP_443200	Q6Q788	APOA5_HUMAN	apolipoprotein AV precursor	326					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding				0	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		TTGAAACTCTGGGGCGAAGGC	0.597			NA											15	28					0.00074312	0.000858512	0.006122	1	0
PVRL1	5818	broad.mit.edu	37	11	119509492	119509492	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr11:119509492C>A	uc001pwu.1	-	7	1348	c.1176G>T	c.(1174-1176)AAG>AAT	p.K392N		NM_203285	NP_976030	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 2	Error:Variant_position_missing_in_Q15223_after_alignment					adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		AAGGCTCCGGCTTCTGGGAGA	0.632			NA											5	17					3.59834e-05	4.49188e-05	0.001168	1	0
NECAP1	25977	broad.mit.edu	37	12	8244385	8244385	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr12:8244385A>G	uc001qtx.2	+	4	400	c.322A>G	c.(322-324)ATT>GTT	p.I108V	NECAP1_uc001qty.2_Intron	NM_015509	NP_056324	Q8NC96	NECP1_HUMAN	NECAP endocytosis associated 1	108					endocytosis|protein transport	clathrin coated vesicle membrane|plasma membrane				ovary(1)	1				Kidney(36;0.0915)		TTTCATTGGCATTGGCTTCAC	0.398			NA											3	35					0	0	0.004672	0	0
GRIN2B	2904	broad.mit.edu	37	12	13768186	13768186	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr12:13768186C>A	uc001rbt.2	-	7	1695	c.1516G>T	c.(1516-1518)GCC>TCC	p.A506S		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	506	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCCATGTAGGCCCTCTTCATG	0.502			NA											7	42					8.12818e-05	9.94633e-05	0.001984	1	0
ATF7IP	55729	broad.mit.edu	37	12	14578064	14578064	+	Silent	SNP	T	T	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr12:14578064T>C	uc001rbw.2	+	2	1373	c.1215T>C	c.(1213-1215)GAT>GAC	p.D405D	ATF7IP_uc010shs.1_Silent_p.D405D|ATF7IP_uc001rbu.2_Silent_p.D405D|ATF7IP_uc001rbv.1_Silent_p.D405D|ATF7IP_uc001rbx.2_Silent_p.D405D|ATF7IP_uc010sht.1_Silent_p.D405D|ATF7IP_uc001rby.3_Silent_p.D405D|ATF7IP_uc001rbz.1_Silent_p.D405D|ATF7IP_uc001rca.2_Silent_p.D405D|ATF7IP_uc001rcb.2_Silent_p.D16D	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	405	Glu-rich.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						CTTCTGCAGATCTTGTAGAAA	0.328			NA											4	76					0	0	0.000602	0	0
OVCH1	341350	broad.mit.edu	37	12	29614910	29614910	+	Silent	SNP	A	A	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr12:29614910A>T	uc001rix.1	-	19	2157	c.2157T>A	c.(2155-2157)ATT>ATA	p.I719I		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	719	Peptidase S1 2.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					CATGCACTTGAATCTGCTGTA	0.433			NA											12	146					0	0	0.001855	0	0
CDK17	5128	broad.mit.edu	37	12	96694092	96694092	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr12:96694092T>C	uc001tep.1	-	6	1079	c.590A>G	c.(589-591)AAG>AGG	p.K197R	CDK17_uc009ztk.2_Missense_Mutation_p.K197R|CDK17_uc010svb.1_Missense_Mutation_p.K144R	NM_002595	NP_002586	Q00537	CDK17_HUMAN	PCTAIRE protein kinase 2	197	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity			ovary(3)|lung(2)|kidney(1)|central_nervous_system(1)	7						CTCTCCAAGCTTTTCCAATTT	0.279			NA											3	79					0	0	0.004672	0	0
MPHOSPH8	54737	broad.mit.edu	37	13	20240685	20240685	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr13:20240685C>T	uc001umh.2	+	10	2149	c.2140C>T	c.(2140-2142)CTT>TTT	p.L714F	MPHOSPH8_uc001umg.2_Missense_Mutation_p.L714F	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	714	ANK 4.				cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		TAACAATGTGCTTGTGTACGA	0.408			NA											3	82					0	0	0.004672	0	0
ZMYM5	9205	broad.mit.edu	37	13	20425887	20425888	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr13:20425887_20425888CC>AA	uc010tcn.1	-	3	698_699	c.433_434GG>TT	c.(433-435)GGA>TTA	p.G145L	ZMYM5_uc001umm.1_5'UTR|ZMYM5_uc001umn.2_Missense_Mutation_p.G145L|ZMYM5_uc001umo.2_Missense_Mutation_p.G145L	NM_001142684	NP_001136156	Q9UJ78	ZMYM5_HUMAN	zinc finger protein 237 isoform 3	145						nucleus	zinc ion binding				0		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		GTTTTTAGTTCCAGGAAGTCCC	0.366			NA											8	117					0	0	0.004672	0	0
XPO4	64328	broad.mit.edu	37	13	21373447	21373447	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr13:21373447A>T	uc001unq.3	-	16	2215	c.2179T>A	c.(2179-2181)TGG>AGG	p.W727R		NM_022459	NP_071904	Q9C0E2	XPO4_HUMAN	exportin 4	727					protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		GCTAAATTCCACCAGTTCTCA	0.338			NA											6	70					0	0	0.001984	0	0
MTMR6	9107	broad.mit.edu	37	13	25848295	25848295	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr13:25848295T>C	uc001uqf.3	-	2	374	c.55A>G	c.(55-57)AGT>GGT	p.S19G	MTMR6_uc001uqe.1_Missense_Mutation_p.S19G	NM_004685	NP_004676	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	19						cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)|skin(2)	4		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		TTGCTGGTACTGAATCGGTCA	0.348			NA											5	52					0	0	0.000602	0	0
PAN3	255967	broad.mit.edu	37	13	28854560	28854560	+	Missense_Mutation	SNP	C	C	G	rs141442348		TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr13:28854560C>G	uc001urz.2	+	15	1771	c.1763C>G	c.(1762-1764)ACT>AGT	p.T588S	PAN3_uc001ury.2_Missense_Mutation_p.T422S|PAN3_uc001urx.2_Missense_Mutation_p.T534S	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease	734	Protein kinase.|Interaction with PAN2.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		TATTTGTTGACTGACCAAAAC	0.383			NA											3	85					0	0	0.004672	0	0
FLT1	2321	broad.mit.edu	37	13	29041231	29041231	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr13:29041231A>G	uc001usb.3	-	3	482	c.197T>C	c.(196-198)ATG>ACG	p.M66T	FLT1_uc010aar.1_Missense_Mutation_p.M66T|FLT1_uc001usc.3_Missense_Mutation_p.M66T|FLT1_uc010tdp.1_Missense_Mutation_p.M66T|FLT1_uc001usd.2_Missense_Mutation_p.M66T	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	66	Ig-like C2-type 1.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CTTACTCACCATTTCAGGCAA	0.448			NA											20	107					0	0	0.00333	0	0
FRY	10129	broad.mit.edu	37	13	32653165	32653165	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr13:32653165C>T	uc001utx.2	+	2	761	c.265C>T	c.(265-267)CCC>TCC	p.P89S	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	89					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TATGGCAGAGCCCCTGGTGAG	0.403			NA											20	114					0	0	0.001523	0	0
PCDH8	5100	broad.mit.edu	37	13	53422550	53422550	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr13:53422550C>A	uc001vhi.2	-	1	225	c.22G>T	c.(22-24)GGC>TGC	p.G8C	PCDH8_uc001vhj.2_Missense_Mutation_p.G8C	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	8					cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CAGGGGCTGCCCCAACGCCTC	0.592	GBM(36;25 841 9273 49207)		NA											4	51					0.00024832	0.000297984	0.000248	1	0
PCDH17	27253	broad.mit.edu	37	13	58207733	58207733	+	Silent	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr13:58207733C>A	uc001vhq.1	+	1	1945	c.1053C>A	c.(1051-1053)ATC>ATA	p.I351I	PCDH17_uc010aec.1_Silent_p.I351I	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	351	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CGCCGTCCATCGGTTTCGTCT	0.662	Melanoma(72;952 1291 1619 12849 33676)		NA											4	36					3.59834e-05	4.49188e-05	0.001168	1	0
GPC5	2262	broad.mit.edu	37	13	92560221	92560221	+	Silent	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr13:92560221C>A	uc010tif.1	+	6	1677	c.1311C>A	c.(1309-1311)ATC>ATA	p.I437I		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	437						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GAAATGGAATCAAAGCCCAGT	0.393			NA											11	59					3.07112e-06	4.10955e-06	0.000978	1	0
GPC5	2262	broad.mit.edu	37	13	93518617	93518617	+	Silent	SNP	A	A	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr13:93518617A>T	uc010tif.1	+	8	2010	c.1644A>T	c.(1642-1644)GCA>GCT	p.A548A		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	548						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				CAACAGGAGCAGGATGTGCAG	0.438			NA											11	82					0	0	0.008291	0	0
NPAS3	64067	broad.mit.edu	37	14	34243683	34243683	+	Silent	SNP	T	T	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr14:34243683T>C	uc001wru.2	+	8	1057	c.993T>C	c.(991-993)CAT>CAC	p.H331H	NPAS3_uc001wrs.2_Silent_p.H318H|NPAS3_uc001wrt.2_Silent_p.H299H|NPAS3_uc001wrv.2_Silent_p.H301H	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	331	PAS 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		TTGACTGCCATATGTTCGTCA	0.468			NA											30	95					0	0	0.002445	0	0
SOS2	6655	broad.mit.edu	37	14	50600930	50600930	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr14:50600930C>A	uc001wxs.3	-	19	3084	c.2986G>T	c.(2986-2988)GGA>TGA	p.G996*	SOS2_uc010tql.1_Nonsense_Mutation_p.G963*	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	996	Ras-GEF.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					GATGCACTTCCCATGGGGTTA	0.313			NA											28	134					6.38683e-12	9.81777e-12	0.008361	1	0
FAM181A	90050	broad.mit.edu	37	14	94394801	94394802	+	Missense_Mutation	DNP	GG	GG	TT	rs146784848		TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr14:94394801_94394802GG>TT	uc001ybz.1	+	3	663_664	c.356_357GG>TT	c.(355-357)CGG>CTT	p.R119L	C14orf86_uc001yby.2_5'Flank|FAM181A_uc010aus.1_Missense_Mutation_p.R57L|FAM181A_uc001yca.1_Missense_Mutation_p.R57L	NM_138344	NP_612353	Q8N9Y4	F181A_HUMAN	hypothetical protein LOC90050	119											0						CGGCTCCCGCGGGGCCTTCCTG	0.658			NA											8	22					0	0	0.004672	0	0
MAGEL2	54551	broad.mit.edu	37	15	23889141	23889141	+	Silent	SNP	T	T	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr15:23889141T>C	uc001ywj.3	-	1	2035	c.1940A>G	c.(1939-1941)TAA>TGA	p.*647*		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		CTACACCTATTAGCGGGGAGG	0.587			NA											5	22					0	0	0.000602	0	0
C15orf2	23742	broad.mit.edu	37	15	24921430	24921430	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr15:24921430A>T	uc001ywo.2	+	1	890	c.416A>T	c.(415-417)AAG>ATG	p.K139M		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	139					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		AAGGCCAGGAAGCCCATCCCA	0.622			NA											6	41					0	0	0.001168	0	0
CEP152	22995	broad.mit.edu	37	15	49054774	49054774	+	Silent	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr15:49054774G>A	uc001zwy.2	-	18	2410	c.2376C>T	c.(2374-2376)GGC>GGT	p.G792G	CEP152_uc001zwz.2_Silent_p.G792G|CEP152_uc001zxa.1_Silent_p.G699G	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	792					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		CAGTTTGGCTGCCACAATCTA	0.388			NA											4	100					0	0	0.000602	0	0
DMXL2	23312	broad.mit.edu	37	15	51741321	51741321	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr15:51741321G>A	uc002abf.2	-	43	9196	c.8971C>T	c.(8971-8973)CGA>TGA	p.R2991*	DMXL2_uc002abd.2_Nonsense_Mutation_p.R1083*|DMXL2_uc010ufy.1_Nonsense_Mutation_p.R2992*|DMXL2_uc010bfa.2_Nonsense_Mutation_p.R2355*|DMXL2_uc002abc.2_RNA	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2991						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		CCAATGTTTCGAAATATGGAC	0.438			NA											31	101					0	0	0.002836	0	0
LOC645752	645752	broad.mit.edu	37	15	78207582	78207582	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr15:78207582C>A	uc010bky.2	-	18	2094	c.1330G>T	c.(1330-1332)GAC>TAC	p.D444Y	LOC645752_uc010umq.1_Missense_Mutation_p.D91Y|uc002bcw.1_5'Flank|uc002bcx.1_5'Flank	NR_027024				SubName: Full=GOLGA6 protein; Flags: Fragment;												0						GTGGGGTTGTCATGGGGAGAA	0.572			NA											12	45					3.27435e-08	4.61386e-08	0.00245	1	0
ADAMTSL3	57188	broad.mit.edu	37	15	84659933	84659933	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr15:84659933G>T	uc002bjz.3	+	23	4164	c.3940G>T	c.(3940-3942)GGA>TGA	p.G1314*	ADAMTSL3_uc010bmt.1_Nonsense_Mutation_p.G1314*|ADAMTSL3_uc010bmu.1_Nonsense_Mutation_p.G1314*	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1314	Ig-like C2-type 3.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGCAGCCCTTGGAGCAAACGT	0.498			NA											45	187					2.77807e-22	4.61358e-22	0.003214	1	0
MYH11	4629	broad.mit.edu	37	16	15814806	15814806	+	Missense_Mutation	SNP	C	C	T	rs138863103		TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr16:15814806C>T	uc002ddy.2	-	33	4788	c.4681G>A	c.(4681-4683)GCC>ACC	p.A1561T	MYH11_uc002ddv.2_Missense_Mutation_p.A1568T|MYH11_uc002ddw.2_Missense_Mutation_p.A1561T|MYH11_uc002ddx.2_Missense_Mutation_p.A1568T|MYH11_uc010bvg.2_Missense_Mutation_p.A1393T|NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron|MYH11_uc010bvh.2_Missense_Mutation_p.A267T|NDE1_uc002ddz.1_5'Flank	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1561	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CGCAGTTTGGCGTCCTCCGTG	0.602			NA	T	CBFB	AML								13	81					0	0	0.001855	0	0
XYLT1	64131	broad.mit.edu	37	16	17211812	17211812	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr16:17211812C>A	uc002dfa.2	-	11	2333	c.2248G>T	c.(2248-2250)GAG>TAG	p.E750*		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	750	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						AATAGCCTCTCCTTGGCATCC	0.572			NA											5	40					0.000602214	0.000708936	0.000602	1	0
TNK1	8711	broad.mit.edu	37	17	7291918	7291918	+	Missense_Mutation	SNP	A	A	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr17:7291918A>C	uc002ggi.3	+	11	1846	c.1686A>C	c.(1684-1686)AGA>AGC	p.R562S	TNK1_uc002ggj.3_Missense_Mutation_p.R557S|TNK1_uc010cmf.2_RNA|TNK1_uc002ggk.3_Intron	NM_003985	NP_003976	Q13470	TNK1_HUMAN	tyrosine kinase, non-receptor, 1	562	Pro-rich.				protein autophosphorylation	membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(122;0.157)				GGCCCAAAAGAAAACCCCCAC	0.607			NA											7	24					0	0	0.001984	0	0
EVI2A	2123	broad.mit.edu	37	17	29645432	29645432	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr17:29645432T>G	uc002hgm.2	-	2	815	c.600A>C	c.(598-600)AAA>AAC	p.K200N	NF1_uc002hgg.2_Intron|NF1_uc002hgh.2_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.2_Intron|EVI2A_uc002hgl.2_Missense_Mutation_p.K223N	NM_014210	NP_055025	P22794	EVI2A_HUMAN	ecotropic viral integration site 2A isoform 2	200	Cytoplasmic (Potential).					integral to membrane	transmembrane receptor activity			ovary(1)|breast(1)	2		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;5.94e-13)|Epithelial(4;7.98e-12)|OV - Ovarian serous cystadenocarcinoma(4;9.4e-12)|GBM - Glioblastoma multiforme(4;0.18)		CTGTGAGCTGTTTTGTTCTTT	0.453			NA											6	44					0	0	0.004482	0	0
SLFN13	146857	broad.mit.edu	37	17	33769261	33769261	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr17:33769261C>A	uc002hjk.1	-	3	1573	c.1243G>T	c.(1243-1245)GAG>TAG	p.E415*	SLFN13_uc010wch.1_Nonsense_Mutation_p.E415*|SLFN13_uc002hjl.2_Nonsense_Mutation_p.E415*|SLFN13_uc010ctt.2_Nonsense_Mutation_p.E97*|SLFN13_uc002hjm.2_Nonsense_Mutation_p.E84*	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	415						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		AAAGACAGCTCCTTCCAGAGG	0.428			NA											6	61					3.59834e-05	4.49188e-05	0.001168	1	0
GDPD1	284161	broad.mit.edu	37	17	57311875	57311875	+	Silent	SNP	T	T	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr17:57311875T>C	uc002ixk.1	+	2	302	c.165T>C	c.(163-165)AAT>AAC	p.N55N	GDPD1_uc002ixj.2_Silent_p.N55N	NM_182569	NP_872375	Q8N9F7	GDPD1_HUMAN	glycerophosphodiester phosphodiesterase domain	55	Cytoplasmic (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process	cytoplasm|integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					ATTTGGAGAATACAATGGCAG	0.289			NA											5	65					0	0	0.001168	0	0
RGS9	8787	broad.mit.edu	37	17	63133675	63133675	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr17:63133675A>G	uc002jfe.2	+	1	127	c.17A>G	c.(16-18)CAA>CGA	p.Q6R	RGS9_uc010dem.2_Missense_Mutation_p.Q6R|RGS9_uc002jfd.2_Missense_Mutation_p.Q6R|RGS9_uc002jff.2_RNA	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	6					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						ATCCGACACCAAGGCCAGCAG	0.622			NA											8	54					0	0	0.008291	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14851640	14851640	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr18:14851640G>T	uc010dlo.2	+	36	3520	c.3340G>T	c.(3340-3342)GAG>TAG	p.E1114*	ANKRD30B_uc010xal.1_Nonsense_Mutation_p.E256*	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1199	Potential.									ovary(1)|skin(1)	2						TAAATACTTTGAGGACATTAA	0.348			NA											7	24					2.17888e-05	2.79497e-05	0.006214	1	0
RTTN	25914	broad.mit.edu	37	18	67727182	67727182	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr18:67727182G>A	uc002lkp.2	-	36	4912	c.4844C>T	c.(4843-4845)TCA>TTA	p.S1615L	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Missense_Mutation_p.S703L|RTTN_uc010dqp.2_5'UTR	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	1615							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				GCACATTGCTGAAAGAAGAGA	0.468			NA											22	36					0	0	0.001882	0	0
SALL3	27164	broad.mit.edu	37	18	76754914	76754914	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr18:76754914C>A	uc002lmt.2	+	2	2923	c.2923C>A	c.(2923-2925)CCC>ACC	p.P975T	SALL3_uc010dra.2_Intron	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	975					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GGGTAAGTGTCCCAGCACTGT	0.463			NA											10	12					7.48243e-07	1.01586e-06	0.006214	1	0
PALM	5064	broad.mit.edu	37	19	746366	746366	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr19:746366C>A	uc002lpm.1	+	9	910	c.716C>A	c.(715-717)GCG>GAG	p.A239E	PALM_uc002lpn.1_Missense_Mutation_p.A195E|PALM_uc010xfu.1_Missense_Mutation_p.A104E	NM_002579	NP_002570	O75781	PALM_HUMAN	paralemmin isoform 1	239					cellular component movement|negative regulation of adenylate cyclase activity|negative regulation of dopamine receptor signaling pathway|positive regulation of filopodium assembly|regulation of cell shape	cytoplasmic membrane-bounded vesicle|filopodium membrane|integral to plasma membrane					0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)|Lung(535;0.201)		ATCCACAAAGCGGACGAGGTC	0.697			NA											15	36					1.5739e-10	2.32337e-10	0.004007	1	0
COL5A3	50509	broad.mit.edu	37	19	10102467	10102467	+	Silent	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr19:10102467G>A	uc002mmq.1	-	23	2030	c.1944C>T	c.(1942-1944)TCC>TCT	p.S648S		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	648	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			TTCAAACCTGGGACCCATGGT	0.557			NA											6	106					0	0	0.004482	0	0
KEAP1	9817	broad.mit.edu	37	19	10600347	10600347	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr19:10600347A>T	uc002moq.1	-	4	1664	c.1508T>A	c.(1507-1509)ATG>AAG	p.M503K	KEAP1_uc002mop.1_Missense_Mutation_p.M221K|KEAP1_uc002mor.1_Missense_Mutation_p.M503K	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	503	Kelch 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GATGGTGTTCATTGCTGTGAT	0.597			NA											22	49					0	0	0.00333	0	0
KRI1	65095	broad.mit.edu	37	19	10668512	10668512	+	Silent	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr19:10668512C>A	uc002moy.1	-	15	1446	c.1437G>T	c.(1435-1437)ACG>ACT	p.T479T	KRI1_uc002mow.1_Silent_p.T98T|KRI1_uc002mox.1_Silent_p.T475T	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	479										ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			TCTTCTTGCCCGTCAAGGGGG	0.677			NA											5	27					2.7689e-08	3.93141e-08	0.001984	1	0
EMR2	30817	broad.mit.edu	37	19	14854511	14854511	+	Silent	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr19:14854511G>T	uc002mzp.1	-	19	2725	c.2269C>A	c.(2269-2271)CGG>AGG	p.R757R	EMR2_uc010dzs.1_Silent_p.R216R|EMR2_uc010xnw.1_Silent_p.R699R|EMR2_uc002mzo.1_Silent_p.R746R|EMR2_uc002mzq.1_Silent_p.R697R|EMR2_uc002mzr.1_Silent_p.R708R|EMR2_uc002mzs.1_Silent_p.R615R|EMR2_uc002mzt.1_Silent_p.R653R|EMR2_uc002mzu.1_Silent_p.R664R|EMR2_uc010xnx.1_RNA	NM_013447	NP_038475	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone	757	Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			lung(2)|ovary(1)|skin(1)	4						GCCATGACCCGGGCAGCCGGA	0.577			NA											44	67					5.48756e-27	9.19537e-27	0.002852	1	0
NLRP13	126204	broad.mit.edu	37	19	56424482	56424482	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr19:56424482A>T	uc010ygg.1	-	5	726	c.701T>A	c.(700-702)GTG>GAG	p.V234E		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	234	NACHT.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TGCCCTCCCCACCAAGACTAT	0.502			NA											55	106					0	0	0.00361	0	0
GREB1	9687	broad.mit.edu	37	2	11740993	11740993	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr2:11740993T>C	uc002rbk.1	+	16	2701	c.2401T>C	c.(2401-2403)TGC>CGC	p.C801R	GREB1_uc002rbo.1_Missense_Mutation_p.C435R	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	801						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		ATTGCTCAACTGCAGGGAGGT	0.527	Ovarian(39;850 945 2785 23371 33093)		NA											43	182					0	0	0.00361	0	0
GALNT14	79623	broad.mit.edu	37	2	31147016	31147016	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr2:31147016G>T	uc002rnr.2	-	13	1968	c.1349C>A	c.(1348-1350)GCC>GAC	p.A450D	GALNT14_uc002rnq.2_Missense_Mutation_p.A430D|GALNT14_uc002rns.2_Missense_Mutation_p.A455D|GALNT14_uc010ymr.1_Missense_Mutation_p.A415D|GALNT14_uc010ezo.1_Missense_Mutation_p.A417D	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	450	Lumenal (Potential).|Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					TTTGACCTTGGCACAGGGGCT	0.517			NA											54	189					9.79885e-19	1.55777e-18	0.00361	1	0
TEKT4	150483	broad.mit.edu	37	2	95537412	95537412	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr2:95537412G>A	uc002stw.1	+	1	181	c.88G>A	c.(88-90)GCC>ACC	p.A30T	uc002stv.1_Intron|TEKT4_uc010fhr.1_RNA	NM_144705	NP_653306	Q8WW24	TEKT4_HUMAN	tektin 4	30					cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|breast(1)|skin(1)	3						CTCCGGCCTGGCCACCGCCAG	0.672			NA											4	27					0	0	0.000248	0	0
IL1RL1	9173	broad.mit.edu	37	2	102956626	102956627	+	Missense_Mutation	DNP	CA	CA	AG			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr2:102956626_102956627CA>AG	uc002tbu.1	+	4	612_613	c.341_342CA>AG	c.(340-342)CCA>CAG	p.P114Q	IL1RL1_uc010ywa.1_5'UTR|IL18R1_uc002tbw.3_Intron|IL1RL1_uc002tbv.2_Missense_Mutation_p.P114Q	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1 isoform 1	114	Ig-like C2-type 2.|Extracellular (Potential).				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			skin(2)|ovary(1)|central_nervous_system(1)	4						TGCAATGTTCCAGATTATTTGA	0.347			NA											16	50					0	0	0.004672	0	0
MKI67IP	84365	broad.mit.edu	37	2	122488515	122488515	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr2:122488515C>G	uc002tnk.2	-	4	595	c.518G>C	c.(517-519)AGG>ACG	p.R173T	MKI67IP_uc010fls.2_Missense_Mutation_p.R173T	NM_032390	NP_115766	Q9BYG3	MK67I_HUMAN	MKI67 interacting nucleolar phosphoprotein	173					protein complex assembly|rRNA metabolic process|rRNA transcription	condensed nuclear chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding				0						TAATTTCTTCCTGAGTAATCT	0.393			NA											12	116					0	0	0.001855	0	0
TUBA3E	112714	broad.mit.edu	37	2	130953906	130953906	+	Silent	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr2:130953906G>T	uc002tqv.2	-	2	143	c.42C>A	c.(40-42)GTC>GTA	p.V14V		NM_207312	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	14					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1	Colorectal(110;0.1)					TGCCGATCTGGACACCCGCCT	0.502			NA											15	68					1.1804e-14	1.86062e-14	0.003954	1	0
CCDC74A	90557	broad.mit.edu	37	2	132288316	132288316	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr2:132288316G>T	uc002tta.2	+	3	512	c.460G>T	c.(460-462)GGC>TGC	p.G154C	CCDC74A_uc002ttb.2_Intron	NM_138770	NP_620125	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	154										skin(1)	1						GCGTCTTGCGGGCGGTAGCGC	0.632			NA											6	77					3.59834e-05	4.49188e-05	0.001168	1	0
NCKAP5	344148	broad.mit.edu	37	2	133486442	133486443	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr2:133486442_133486443CC>AT	uc002ttp.2	-	18	5900_5901	c.5526_5527GG>AT	c.(5524-5529)ATGGCA>ATATCA	p.1842_1843MA>IS	NCKAP5_uc002ttq.2_Missense_Mutation_p.523_524MA>IS	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1842_1843							protein binding				0						GGCTGGCTTGCCATTGGGTCTT	0.554			NA											27	119					0	0	0.004672	0	0
LRP1B	53353	broad.mit.edu	37	2	141625676	141625676	+	Silent	SNP	T	T	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr2:141625676T>A	uc002tvj.1	-	26	5298	c.4326A>T	c.(4324-4326)ACA>ACT	p.T1442T	LRP1B_uc010fnl.1_Silent_p.T624T	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1442	Extracellular (Potential).|LDL-receptor class B 12.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACCTGGCGTCTGTCCACACTA	0.363	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			26	96					0	0	0.005443	0	0
HOXD8	3234	broad.mit.edu	37	2	176995521	176995521	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr2:176995521C>A	uc002uko.2	+	1	1045	c.427C>A	c.(427-429)CAG>AAG	p.Q143K	uc002ukl.1_5'Flank|uc002ukm.1_5'Flank|HOXD8_uc002ukn.2_Intron|HOXD8_uc002ukp.2_Missense_Mutation_p.Q143K	NM_019558	NP_062458	P13378	HXD8_HUMAN	homeobox D8	143					anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		CGATAACTTACAGAGACAGCC	0.418			NA											21	97					4.26978e-12	6.61815e-12	0.00333	1	0
TTN	7273	broad.mit.edu	37	2	179398651	179398651	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr2:179398651C>T	uc010zfg.1	-	307	95211	c.94987G>A	c.(94987-94989)GAA>AAA	p.E31663K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E25358K|TTN_uc010zfi.1_Missense_Mutation_p.E25291K|TTN_uc010zfj.1_Missense_Mutation_p.E25166K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32590							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCATAGACTTCTCTCACACCT	0.408			NA											7	46					0	0	0.00308	0	0
ZNF804A	91752	broad.mit.edu	37	2	185731221	185731221	+	Nonsense_Mutation	SNP	T	T	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr2:185731221T>A	uc002uph.2	+	2	831	c.237T>A	c.(235-237)TAT>TAA	p.Y79*		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	79	C2H2-type.					intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TTAATTCATATGACCATGCTC	0.353			NA											4	63					0	0	0.000248	0	0
COL3A1	1281	broad.mit.edu	37	2	189849926	189849926	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr2:189849926A>T	uc002uqj.1	+	3	403	c.286A>T	c.(286-288)ACT>TCT	p.T96S		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	96					axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TTATTAGCCTACTCGCCCTCC	0.338			NA											20	66					0	0	0.008871	0	0
IRS1	3667	broad.mit.edu	37	2	227660594	227660594	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr2:227660594C>A	uc002voh.3	-	1	2913	c.2861G>T	c.(2860-2862)TGG>TTG	p.W954L		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	954					fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		GCTCTCCTGCCAGGCTGCCCT	0.672			NA											14	79					3.52763e-06	4.65347e-06	0.00499	1	0
CASS4	57091	broad.mit.edu	37	20	55012296	55012297	+	Missense_Mutation	DNP	TG	TG	CT			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr20:55012296_55012297TG>CT	uc002xxp.2	+	3	338_339	c.113_114TG>CT	c.(112-114)CTG>CCT	p.L38P	CASS4_uc002xxq.3_Missense_Mutation_p.L38P|CASS4_uc002xxr.2_Missense_Mutation_p.L38P|CASS4_uc010zze.1_Missense_Mutation_p.L38P|CASS4_uc010gio.2_Missense_Mutation_p.L38P	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	38	SH3.				cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						GGGGACATCCTGACCATTCTGG	0.594			NA											8	71					0	0	0.004672	0	0
CRYZL1	9946	broad.mit.edu	37	21	34974653	34974653	+	Splice_Site	SNP	T	T	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr21:34974653T>A	uc011adw.1	-	8	646	c.466_splice	c.e8-1	p.A156_splice	DONSON_uc002ysn.1_Intron|CRYZL1_uc002ysr.1_Splice_Site_p.A180_splice|CRYZL1_uc002yss.1_Splice_Site|CRYZL1_uc002yst.1_Splice_Site	NM_145858	NP_665857	O95825	QORL1_HUMAN	crystallin, zeta-like 1						quinone cofactor metabolic process	cytosol	NADP binding|NADPH:quinone reductase activity|zinc ion binding				0						ACCAAATGCCTGTGTAGAAAA	0.338			NA											12	45					0	0	0.001368	0	0
TATDN2	9797	broad.mit.edu	37	3	10320619	10320619	+	Silent	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr3:10320619G>A	uc003bvg.2	+	7	2777	c.2196G>A	c.(2194-2196)ACG>ACA	p.T732T	TATDN2_uc003bvf.2_Silent_p.T732T|TATDN2_uc011atr.1_Silent_p.T732T|TATDN2_uc011ats.1_RNA|TATDN2_uc011att.1_RNA|TATDN2_uc011atu.1_5'Flank|TATDN2_uc011atv.1_5'Flank|GHRLOS_uc011atw.1_5'Flank|GHRLOS_uc011atx.1_5'Flank|GHRLOS_uc011aty.1_5'Flank|GHRLOS_uc011atz.1_5'Flank|GHRLOS_uc011aua.1_5'Flank|GHRLOS_uc010hdl.2_5'Flank|GHRLOS_uc011aub.1_5'Flank|GHRLOS_uc010hdm.2_5'Flank|GHRLOS_uc011auc.1_5'Flank|GHRLOS_uc011aud.1_5'Flank|GHRLOS_uc011aue.1_5'Flank|GHRLOS_uc011auf.1_5'Flank|GHRLOS_uc011aug.1_5'Flank	NM_014760	NP_055575	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	732						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			pancreas(2)	2						CCTTGCATACGGTCCGAGAGA	0.537			NA											5	32					0	0	0.000602	0	0
BAP1	8314	broad.mit.edu	37	3	52437180	52437181	+	Missense_Mutation	DNP	AG	AG	TA			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	AG	AG	-	-	AG	AG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr3:52437180_52437181AG>TA	uc003ddx.2	-	14	1978_1979	c.1863_1864CT>TA	c.(1861-1866)CCCTTG>CCTATG	p.L622M	BAP1_uc003ddw.2_Intron|BAP1_uc010hmg.2_RNA|BAP1_uc010hmh.2_Intron	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	622	Interaction with BRCA1.				monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		TCCCCACTCAAGGGCTCGCCAG	0.604	GBM(101;493 1458 7992 21037 25532)		NA	N|Mis|F|S|O		uveal melanoma|breast|NSCLC								4	38					0	0	0.004672	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64589670	64589670	+	Silent	SNP	C	C	G			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr3:64589670C>G	uc003dmg.2	-	25	3707	c.3675G>C	c.(3673-3675)CTG>CTC	p.L1225L	ADAMTS9_uc011bfo.1_Silent_p.L1197L|ADAMTS9_uc003dmh.1_Silent_p.L1054L|ADAMTS9_uc011bfp.1_Silent_p.L136L	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1225	TSP type-1 7.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CTGGTCTAGGCAGGGTAGCAC	0.542			NA											21	44					0	0	0.008871	0	0
OR5H6	79295	broad.mit.edu	37	3	97983253	97983253	+	Missense_Mutation	SNP	C	C	A	rs36040433	byFrequency	TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr3:97983253C>A	uc003dsi.1	+	1	125	c.125C>A	c.(124-126)CCG>CAG	p.P42Q		NM_001005479	NP_001005479	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H,	42	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3						TGTAAAATACCGCTCTTCCTG	0.418			NA											42	155					1.48734e-19	2.40561e-19	0.003214	1	0
SEC22A	26984	broad.mit.edu	37	3	122942517	122942517	+	Nonsense_Mutation	SNP	T	T	G			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr3:122942517T>G	uc003ege.2	+	3	373	c.294T>G	c.(292-294)TAT>TAG	p.Y98*	SEC22A_uc003egf.2_Nonsense_Mutation_p.Y98*	NM_012430	NP_036562	Q96IW7	SC22A_HUMAN	SEC22 vesicle trafficking protein homolog A	98	Cytoplasmic (Potential).|Longin.				ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|integral to membrane	transporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.0548)		TTACTACTTATAACATGATGA	0.388			NA											50	135					0	0	0.00361	0	0
LRRC15	131578	broad.mit.edu	37	3	194081021	194081021	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr3:194081021T>A	uc003ftu.2	-	2	838	c.752A>T	c.(751-753)TAC>TTC	p.Y251F	LRRC15_uc003ftt.2_Missense_Mutation_p.Y257F	NM_130830	NP_570843	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15 isoform b	251	LRR 9.|Extracellular (Potential).					integral to membrane				ovary(3)	3	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		GTTGGACAGGTAGAGTCTCTG	0.552			NA											16	41					0	0	0.00499	0	0
KIAA0232	9778	broad.mit.edu	37	4	6860175	6860175	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr4:6860175G>T	uc003gjr.3	+	6	923	c.460G>T	c.(460-462)GAG>TAG	p.E154*	KIAA0232_uc003gjq.3_Nonsense_Mutation_p.E154*	NM_014743	NP_055558	Q92628	K0232_HUMAN	hypothetical protein LOC9778	154							ATP binding			ovary(2)	2						CAAAAAGTTAGAGGGGTCTCC	0.328			NA											4	30					0.00116845	0.00134155	0.001168	1	0
KIT	3815	broad.mit.edu	37	4	55569902	55569902	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr4:55569902G>C	uc010igr.2	+	5	856	c.769G>C	c.(769-771)GAG>CAG	p.E257Q	KIT_uc010igs.2_Missense_Mutation_p.E257Q	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	257	Extracellular (Potential).|Ig-like C2-type 3.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TAAACTACAGGAGAAATATAA	0.343			1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				5	46					0	0	0.000602	0	0
WDFY3	23001	broad.mit.edu	37	4	85662997	85662997	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr4:85662997G>A	uc003hpd.2	-	38	6559	c.6151C>T	c.(6151-6153)CGT>TGT	p.R2051C		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2051						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TCCACCACACGCTGTGTGAAA	0.383			NA											9	90					0	0	0.008291	0	0
TMSL3	7117	broad.mit.edu	37	4	91760173	91760173	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr4:91760173C>A	uc003hsy.2	-	1	97	c.16G>T	c.(16-18)GAT>TAT	p.D6Y	FAM190A_uc003hsv.3_Intron|FAM190A_uc010ikv.2_Intron|FAM190A_uc003hsx.2_Intron	NM_183049	NP_898870			thymosin-like 3												0		all_cancers(2;6.48e-24)|all_epithelial(2;3.86e-25)|Colorectal(2;8.52e-12)|all_lung(2;3.73e-07)|Lung NSC(2;7.99e-07)|Renal(2;0.0243)|Hepatocellular(203;0.0411)		Epithelial(2;5.28e-11)|OV - Ovarian serous cystadenocarcinoma(123;8.9e-10)|all cancers(2;3.21e-09)|STAD - Stomach adenocarcinoma(1;0.0201)		TCAGCCATATCGGGTTTGTCA	0.517			NA											20	138					4.96729e-08	6.94674e-08	0.008871	1	0
DCLK2	166614	broad.mit.edu	37	4	151169531	151169531	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr4:151169531G>T	uc003ilm.3	+	14	2050	c.1950G>T	c.(1948-1950)TGG>TGT	p.W650C	DCLK2_uc003iln.3_Missense_Mutation_p.W649C|DCLK2_uc003ilo.3_Missense_Mutation_p.W667C|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	650	Protein kinase.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					GTCACCCCTGGGTGTCAGTAA	0.478	GBM(195;186 2215 13375 16801 37459)		NA											3	36					0.00024832	0.000297984	0.000248	1	0
FGB	2244	broad.mit.edu	37	4	155490722	155490722	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr4:155490722G>C	uc003ioa.3	+	7	1054	c.1015G>C	c.(1015-1017)GAA>CAA	p.E339Q	FGB_uc003iob.3_Intron|FGB_uc010ipv.2_Missense_Mutation_p.E277Q|FGB_uc010ipw.2_Intron|FGB_uc003ioc.3_Missense_Mutation_p.E120Q	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	339	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	GGGACCCACAGAACTTTTGAT	0.363	NSCLC(106;1133 1613 21870 46110 52656)		NA											14	77					0	0	0.00499	0	0
MARCH1	55016	broad.mit.edu	37	4	164506998	164506998	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr4:164506998G>A	uc003iqs.1	-	6	1303	c.326C>T	c.(325-327)TCC>TTC	p.S109F	MARCH1_uc003iqr.1_Missense_Mutation_p.S92F	NM_017923	NP_060393	Q8TCQ1	MARH1_HUMAN	membrane-associated RING-CH protein I	109	RING-CH-type.				antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GTGGAGGCAGGACTGGTGGAC	0.542			NA											9	58					0	0	0.006214	0	0
WDR17	116966	broad.mit.edu	37	4	177069485	177069485	+	Silent	SNP	T	T	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr4:177069485T>C	uc003iuj.2	+	14	2124	c.1968T>C	c.(1966-1968)TAT>TAC	p.Y656Y	WDR17_uc003iuk.2_Silent_p.Y632Y|WDR17_uc003ium.3_Silent_p.Y632Y|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_5'Flank	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	656	WD 12.									ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		CAGATGTATATGGTAGAGTGT	0.358			NA											12	47					0	0	0.001855	0	0
NEIL3	55247	broad.mit.edu	37	4	178257420	178257420	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr4:178257420G>T	uc003iut.2	+	4	689	c.572G>T	c.(571-573)GGG>GTG	p.G191V	NEIL3_uc010irs.2_Missense_Mutation_p.G94V	NM_018248	NP_060718	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3	191					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		CCTGGAGTAGGGAACATCATC	0.378			NA						BER_DNA_glycosylases					15	103					3.52763e-06	4.65347e-06	0.00499	1	0
SEMA5A	9037	broad.mit.edu	37	5	9154736	9154736	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr5:9154736C>T	uc003jek.2	-	12	2057	c.1345G>A	c.(1345-1347)GAG>AAG	p.E449K		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	449	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GGGAAGAGCTCAATCTCTTCC	0.542			NA											8	114					0	0	0.004482	0	0
MYO10	4651	broad.mit.edu	37	5	16680116	16680116	+	Silent	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr5:16680116G>A	uc003jft.3	-	33	4950	c.4482C>T	c.(4480-4482)AAC>AAT	p.N1494N	MYO10_uc011cnb.1_Silent_p.N123N|MYO10_uc011cnc.1_Silent_p.N373N|MYO10_uc011cnd.1_Silent_p.N851N|MYO10_uc011cne.1_Silent_p.N851N|MYO10_uc010itx.2_Silent_p.N1116N	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1494	PH 2.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						TGTCAGTCACGTTTTGAATGG	0.567			NA											3	29					0	0	0.004672	0	0
CDH9	1007	broad.mit.edu	37	5	26881622	26881622	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr5:26881622C>A	uc003jgs.1	-	12	2162	c.1993G>T	c.(1993-1995)GGG>TGG	p.G665W	CDH9_uc011cnv.1_Missense_Mutation_p.G258W	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	665	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TCTTCTTCCCCGCCGCCTTCA	0.428	Melanoma(8;187 585 15745 40864 52829)		NA											19	166					7.21436e-19	1.15679e-18	0.008871	1	0
PDE4D	5144	broad.mit.edu	37	5	58271618	58271618	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr5:58271618G>A	uc003jsa.2	-	14	2051	c.1879C>T	c.(1879-1881)CCT>TCT	p.P627S	PDE4D_uc003jrx.2_Missense_Mutation_p.P491S|PDE4D_uc003jry.2_Missense_Mutation_p.P325S|PDE4D_uc003jrz.2_Missense_Mutation_p.P563S|PDE4D_uc003jsb.2_Missense_Mutation_p.P566S|PDE4D_uc003jrt.2_Missense_Mutation_p.P325S|PDE4D_uc003jru.2_Missense_Mutation_p.P403S|PDE4D_uc003jrv.2_Missense_Mutation_p.P497S|PDE4D_uc003jrw.2_Missense_Mutation_p.P505S|PDE4D_uc003jrs.2_Missense_Mutation_p.P336S	NM_001104631	NP_001098101	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 1	627					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	AGCTGGAGAGGCTTTGTTGGG	0.483			NA											5	26					0	0	0.001168	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203159	140203159	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr5:140203159C>T	uc003lhl.2	+	1	1799	c.1799C>T	c.(1798-1800)TCG>TTG	p.S600L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.S600L|PCDHA5_uc003lhj.1_Missense_Mutation_p.S600L	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	600	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACCCTGATTCGGGCTACAAC	0.672			NA											10	54					0	0	0.001368	0	0
PCDHB6	56130	broad.mit.edu	37	5	140531256	140531256	+	Missense_Mutation	SNP	C	C	A	rs147347959		TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr5:140531256C>A	uc003lir.2	+	1	1418	c.1418C>A	c.(1417-1419)GCC>GAC	p.A473D	PCDHB6_uc011dah.1_Missense_Mutation_p.A337D	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	473	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCGTCAGCGCCACAGACAGA	0.642			NA											7	86					0.00621372	0.0070905	0.006214	1	0
PCDHGA8	9708	broad.mit.edu	37	5	140772816	140772816	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr5:140772816G>A	uc003lkd.1	+	1	1334	c.436G>A	c.(436-438)GCG>ACG	p.A146T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.A146T	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	146	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAACGAAATCGCGGTTCCTGG	0.443			NA											23	49					0	0	0.002299	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149221870	149221870	+	Nonsense_Mutation	SNP	C	C	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr5:149221870C>T	uc003lrc.2	+	10	2788	c.2746C>T	c.(2746-2748)CGA>TGA	p.R916*	PPARGC1B_uc003lrb.1_Nonsense_Mutation_p.R916*|PPARGC1B_uc003lrd.2_Nonsense_Mutation_p.R877*|PPARGC1B_uc003lrf.2_Nonsense_Mutation_p.R895*|PPARGC1B_uc003lre.1_Nonsense_Mutation_p.R895*	NM_133263	NP_573570	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor	916	RRM.				estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CATGAGCTCCCGAGAGCTGAA	0.532			NA											8	53					0	0	0.008291	0	0
NMUR2	56923	broad.mit.edu	37	5	151784153	151784153	+	Silent	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr5:151784153G>A	uc003luv.2	-	1	688	c.522C>T	c.(520-522)TCC>TCT	p.S174S		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	174	Helical; Name=4; (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(3)|skin(2)|lung(1)|breast(1)|pancreas(1)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			AGAAGAGCACGGAGAAGCCCC	0.637			NA											11	75					0	0	0.001855	0	0
VARS	7407	broad.mit.edu	37	6	31751989	31751989	+	Splice_Site	SNP	A	A	G			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr6:31751989A>G	uc003nxe.2	-	13	2094	c.1671_splice	c.e13+1	p.Q557_splice	VARS_uc011doi.1_Splice_Site	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase						translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	ACAGTCCCCCACCTGGTATCT	0.572			NA											9	164					0	0	0.006214	0	0
GCM1	8521	broad.mit.edu	37	6	52993300	52993301	+	Nonsense_Mutation	DNP	GG	GG	CT			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr6:52993300_52993301GG>CT	uc003pbp.2	-	6	1223_1224	c.1014_1015CC>AG	c.(1012-1017)TACCAG>TAAGAG	p.338_339YQ>*E		NM_003643	NP_003634	Q9NP62	GCM1_HUMAN	glial cells missing homolog a	338_339						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)	1	Lung NSC(77;0.0755)					GGAAGCTGCTGGTAAAAGGGTT	0.46			NA											17	57					0	0	0.004672	0	0
FAM83B	222584	broad.mit.edu	37	6	54735136	54735136	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr6:54735136C>T	uc003pck.2	+	2	208	c.92C>T	c.(91-93)GCC>GTC	p.A31V		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	31										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					TATCGAGTAGCCATTGATATT	0.388			NA											25	106					0	0	0.00333	0	0
LAMA2	3908	broad.mit.edu	37	6	129465145	129465145	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr6:129465145A>G	uc003qbn.2	+	5	844	c.739A>G	c.(739-741)AGG>GGG	p.R247G	LAMA2_uc003qbo.2_Missense_Mutation_p.R247G	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	247	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GAGATTTCAGAGGATCCGCAC	0.433			NA											15	97					0	0	0.003163	0	0
MOXD1	26002	broad.mit.edu	37	6	132693821	132693821	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr6:132693821G>T	uc003qdf.2	-	4	688	c.589C>A	c.(589-591)CCA>ACA	p.P197T	MOXD1_uc003qde.2_Missense_Mutation_p.P129T	NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1 isoform 2	197	Lumenal (Potential).				catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			ovary(1)	1	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		TCTTTGTTTGGGATGGGGACC	0.363			NA											5	79					1.23904e-05	1.60043e-05	0.000602	1	0
MAP3K5	4217	broad.mit.edu	37	6	137041635	137041635	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr6:137041635T>A	uc003qhc.2	-	2	902	c.541A>T	c.(541-543)ATC>TTC	p.I181F	MAP3K5_uc011edk.1_Missense_Mutation_p.I26F|MAP3K5_uc010kgw.1_Missense_Mutation_p.I181F	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	181					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TAGAGGATGATGTTGTTGGCC	0.468			NA											13	47					0	0	0.00245	0	0
MAP3K5	4217	broad.mit.edu	37	6	137041644	137041644	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr6:137041644C>A	uc003qhc.2	-	2	893	c.532G>T	c.(532-534)GCC>TCC	p.A178S	MAP3K5_uc011edk.1_Missense_Mutation_p.A23S|MAP3K5_uc010kgw.1_Missense_Mutation_p.A178S	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	178					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		ATGTTGTTGGCCATGCTGAAA	0.458			NA											14	44					4.3838e-07	5.99549e-07	0.001855	1	0
CREB5	9586	broad.mit.edu	37	7	28610075	28610075	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr7:28610075C>A	uc003szq.2	+	5	774	c.384C>A	c.(382-384)AAC>AAA	p.N128K	CREB5_uc003szo.2_Missense_Mutation_p.N95K|CREB5_uc003szr.2_Missense_Mutation_p.N121K	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	128					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						ATGACACCAACGTTGTGATTC	0.592			NA											15	71					1.01871e-10	1.52807e-10	0.008871	1	0
NOD1	10392	broad.mit.edu	37	7	30492655	30492655	+	Silent	SNP	C	C	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr7:30492655C>T	uc003tav.2	-	6	901	c.378G>A	c.(376-378)GTG>GTA	p.V126V	NOD1_uc010kvs.2_Silent_p.V126V	NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	126					activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						TATACCTGCTCACTGGAGGGA	0.582			NA											11	52					0	0	0.00245	0	0
PSPH	5723	broad.mit.edu	37	7	56087408	56087408	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr7:56087408C>G	uc003trg.2	-	4	523	c.160G>C	c.(160-162)GGG>CGG	p.G54R	PSPH_uc003trh.2_Missense_Mutation_p.G54R|PSPH_uc003tri.2_Missense_Mutation_p.G54R|PSPH_uc003trj.2_Missense_Mutation_p.G83R	NM_004577	NP_004568	P78330	SERB_HUMAN	phosphoserine phosphatase	54					L-serine biosynthetic process	cytoplasm	calcium ion binding|magnesium ion binding|phosphoserine phosphatase activity|protein homodimerization activity			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GGCACTGCCCCGCCCATGGCT	0.617			NA											3	27					0	0	0.000248	0	0
DTX2	113878	broad.mit.edu	37	7	76121568	76121568	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr7:76121568C>A	uc003uff.3	+	6	1563	c.1007C>A	c.(1006-1008)GCA>GAA	p.A336E	DTX2_uc011kgk.1_Missense_Mutation_p.A245E|DTX2_uc003ufg.3_Missense_Mutation_p.A336E|DTX2_uc003ufh.3_Missense_Mutation_p.A336E|DTX2_uc003ufj.3_Missense_Mutation_p.A336E|DTX2_uc003ufk.3_Missense_Mutation_p.A14E	NM_020892	NP_065943	Q86UW9	DTX2_HUMAN	deltex 2 isoform a	336					Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			ovary(1)|skin(1)	2						CAGGCGCTCGCAGGTAGGTGC	0.647			NA											14	31					1.15088e-07	1.59749e-07	0.004007	1	0
HGF	3082	broad.mit.edu	37	7	81386504	81386504	+	Splice_Site	SNP	C	C	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr7:81386504C>T	uc003uhl.2	-	4	647	c.482_splice	c.e4+1	p.S161_splice	HGF_uc003uhm.2_Splice_Site_p.S161_splice|HGF_uc003uhn.1_Splice_Site_p.S161_splice|HGF_uc003uho.1_Splice_Site_p.S161_splice|HGF_uc003uhp.2_Splice_Site_p.S161_splice	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1						epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						ACTGTTCTTACCTGTGTTCGT	0.388			NA											15	42					0	0	0.004007	0	0
TAF6	6878	broad.mit.edu	37	7	99705129	99705129	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr7:99705129G>C	uc003uti.2	-	15	1855	c.1774C>G	c.(1774-1776)CCC>GCC	p.P592A	AP4M1_uc003utd.2_Intron|TAF6_uc003utg.2_Missense_Mutation_p.P514A|TAF6_uc003uth.2_Missense_Mutation_p.P649A|TAF6_uc003utk.2_Missense_Mutation_p.P592A|TAF6_uc011kji.1_Missense_Mutation_p.P629A|TAF6_uc003utj.2_Missense_Mutation_p.P582A|TAF6_uc003utl.2_Missense_Mutation_p.P582A|TAF6_uc003utm.2_Missense_Mutation_p.P592A	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	592					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GTGCTGGGGGGTGCGGTGGTG	0.667			NA											22	104					0	0	0.00632	0	0
MOGAT3	346606	broad.mit.edu	37	7	100839574	100839574	+	Silent	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr7:100839574G>T	uc003uyc.2	-	6	932	c.765C>A	c.(763-765)ACC>ACA	p.T255T	MOGAT3_uc010lhr.2_Intron	NM_178176	NP_835470	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	255					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			ovary(2)	2	Lung NSC(181;0.168)|all_lung(186;0.215)					GCTTCTTGAAGGTGAGCTGGC	0.582			NA											4	21					0.000602214	0.000708936	0.000602	1	0
NRCAM	4897	broad.mit.edu	37	7	107823140	107823140	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr7:107823140G>C	uc003vfb.2	-	23	3000	c.2529C>G	c.(2527-2529)GAC>GAG	p.D843E	NRCAM_uc003vfc.2_Missense_Mutation_p.D827E|NRCAM_uc011kmk.1_Missense_Mutation_p.D838E|NRCAM_uc003vfd.2_Missense_Mutation_p.D819E|NRCAM_uc003vfe.2_Missense_Mutation_p.D819E	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	843	Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						ATCACTTACGGTCTTCTCCAG	0.522			NA											10	23					0	0	0.006214	0	0
TAS2R16	50833	broad.mit.edu	37	7	122635164	122635164	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr7:122635164C>G	uc003vkl.1	-	1	591	c.525G>C	c.(523-525)CAG>CAC	p.Q175H		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	175	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						GGAACTGATACTGATGAAAAT	0.418			NA											31	88					0	0	0.002096	0	0
KIAA1549	57670	broad.mit.edu	37	7	138603645	138603645	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr7:138603645C>G	uc011kql.1	-	2	776	c.727G>C	c.(727-729)GTT>CTT	p.V243L	KIAA1549_uc003vuk.3_Missense_Mutation_p.V193L|KIAA1549_uc011kqj.1_Missense_Mutation_p.V243L	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	243						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						GGAGTTGGAACGATGCCCTCA	0.522	NSCLC(119;1534 1718 44213 46230 50068)		NA	O	BRAF	pilocytic astrocytoma								17	64					0	0	0.00499	0	0
MLL3	58508	broad.mit.edu	37	7	151945190	151945190	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr7:151945190T>A	uc003wla.2	-	14	2548	c.2329A>T	c.(2329-2331)AGC>TGC	p.S777C		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	777					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TCTGCCTTGCTTATGTCTGCT	0.423	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								37	191					0	0	0.004289	0	0
MFHAS1	9258	broad.mit.edu	37	8	8748245	8748245	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr8:8748245G>C	uc003wsj.1	-	1	2887	c.2324C>G	c.(2323-2325)CCC>CGC	p.P775R		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	775											0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		TTCCTGGCTGGGGGTGGACCG	0.617	Melanoma(103;1201 2045 17515 28966)		NA											5	61					0	0	0.001168	0	0
PRSS55	203074	broad.mit.edu	37	8	10396270	10396270	+	Silent	SNP	G	G	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr8:10396270G>C	uc003wta.2	+	5	1041	c.1026G>C	c.(1024-1026)CTG>CTC	p.L342L	uc010lru.2_Intron|PRSS55_uc003wtb.2_Intron	NM_198464	NP_940866	Q6UWB4	PRS55_HUMAN	hypothetical protein LOC203074 precursor	342	Helical; (Potential).				proteolysis	integral to membrane	serine-type endopeptidase activity			ovary(1)	1						TCTGTCCCCTGTCCCATGTGT	0.527			NA											51	152					0	0	0.00361	0	0
EXTL3	2137	broad.mit.edu	37	8	28574048	28574048	+	Nonsense_Mutation	SNP	C	C	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr8:28574048C>T	uc003xgz.1	+	3	1065	c.472C>T	c.(472-474)CGA>TGA	p.R158*		NM_001440	NP_001431	O43909	EXTL3_HUMAN	exostoses-like 3	158	Lumenal (Potential).					integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			skin(2)	2		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		CCTGCCCATCCGACTGCTCCC	0.602			NA											3	45					0	0	0.004672	0	0
MCM4	4173	broad.mit.edu	37	8	48883365	48883365	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr8:48883365G>T	uc003xqk.1	+	12	1824	c.1729G>T	c.(1729-1731)GAC>TAC	p.D577Y	MCM4_uc003xql.1_Missense_Mutation_p.D577Y|MCM4_uc011ldi.1_Missense_Mutation_p.D564Y	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	577	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				CGATGAGTTCGACAAGATGAA	0.498			NA											13	44					2.32078e-09	3.37239e-09	0.003163	1	0
RP1	6101	broad.mit.edu	37	8	55540191	55540191	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr8:55540191G>A	uc003xsd.1	+	4	3897	c.3749G>A	c.(3748-3750)TGT>TAT	p.C1250Y	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1250					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CCTGAAGTCTGTGTTTTGGAA	0.438	Colon(91;1014 1389 7634 14542 40420)		NA											14	159					0	0	0.003163	0	0
TGS1	96764	broad.mit.edu	37	8	56695311	56695311	+	Nonsense_Mutation	SNP	C	C	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr8:56695311C>T	uc003xsj.3	+	2	493	c.106C>T	c.(106-108)CGA>TGA	p.R36*	TGS1_uc010lyh.2_Intron	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	36					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			TCGCAGGGATCGAAAATTGTA	0.318	Esophageal Squamous(34;275 823 4842 34837 48447)		NA											25	78					0	0	0.007291	0	0
CSMD3	114788	broad.mit.edu	37	8	113569029	113569029	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr8:113569029C>A	uc003ynu.2	-	25	4356	c.4197G>T	c.(4195-4197)GAG>GAT	p.E1399D	CSMD3_uc003yns.2_Missense_Mutation_p.E671D|CSMD3_uc003ynt.2_Missense_Mutation_p.E1359D|CSMD3_uc011lhx.1_Missense_Mutation_p.E1295D	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1399	Extracellular (Potential).|Sushi 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATGCCCTTCTCTCCCCTGTCA	0.438			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			13	68					2.68362e-12	4.19457e-12	0.001368	1	0
IFNA4	3441	broad.mit.edu	37	9	21187398	21187398	+	Missense_Mutation	SNP	C	C	T	rs145690832	byFrequency	TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr9:21187398C>T	uc003zon.2	-	1	201	c.133G>A	c.(133-135)GGA>AGA	p.G45R		NM_021068	NP_066546	P05014	IFNA4_HUMAN	interferon, alpha 4 precursor	45					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(5;2.69e-202)|Lung(24;2.26e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		GAGATTCTTCCCATTTGTGCC	0.527	NSCLC(154;890 1986 23660 27800 51138)		NA											24	89					0	0	0.003954	0	0
NOL6	65083	broad.mit.edu	37	9	33469596	33469596	+	Missense_Mutation	SNP	A	A	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr9:33469596A>C	uc003zsz.2	-	5	729	c.628T>G	c.(628-630)TTG>GTG	p.L210V	SUGT1P1_uc010mjq.1_Intron|NOL6_uc003zta.2_Missense_Mutation_p.L210V|NOL6_uc010mjv.2_Missense_Mutation_p.L210V|NOL6_uc011lob.1_Missense_Mutation_p.L150V|NOL6_uc003ztb.1_Missense_Mutation_p.L210V	NM_022917	NP_075068	Q9H6R4	NOL6_HUMAN	nucleolar protein family 6 alpha isoform	210					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		TGGTGAGCCAAGTGGGCCAGG	0.617			NA											4	129					0	0	0.000602	0	0
PAPPA	5069	broad.mit.edu	37	9	118982243	118982243	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr9:118982243C>A	uc004bjn.2	+	5	2327	c.1946C>A	c.(1945-1947)CCC>CAC	p.P649H	PAPPA_uc011lxp.1_Missense_Mutation_p.P344H|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	649					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						TCCTTCACGCCCAATCAAGTC	0.587			NA											24	80					5.35356e-11	8.09562e-11	0.00278	1	0
ENTPD2	954	broad.mit.edu	37	9	139944797	139944797	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr9:139944797C>T	uc004ckw.1	-	6	1024	c.968G>A	c.(967-969)TGC>TAC	p.C323Y	ENTPD2_uc004ckv.1_5'Flank|ENTPD2_uc004ckx.1_Missense_Mutation_p.C323Y	NM_203468	NP_982293	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	323	Extracellular (Potential).					integral to membrane	ATP binding				0	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GGAGAAGGGGCAGGAGGAGAA	0.607			NA									OREG0019627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	106					0	0	0.000602	0	0
MXRA5	25878	broad.mit.edu	37	X	3238914	3238914	+	Silent	SNP	T	T	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chrX:3238914T>C	uc004crg.3	-	5	4969	c.4812A>G	c.(4810-4812)CAA>CAG	p.Q1604Q		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1604						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CTCTGGTTAGTTGATGAGAAG	0.483			NA											19	99					0	0	0.007413	0	0
STS	412	broad.mit.edu	37	X	7267979	7267979	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chrX:7267979G>T	uc004cry.3	+	10	1674	c.1429G>T	c.(1429-1431)GGT>TGT	p.G477C		NM_000351	NP_000342	P08842	STS_HUMAN	steryl-sulfatase precursor	477	Lumenal.				female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			central_nervous_system(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	CAACCCCGTGGGTTCCAACGG	0.478			NA							Ichthyosis				21	104					1.96292e-10	2.87483e-10	0.001523	1	0
FRMPD4	9758	broad.mit.edu	37	X	12632918	12632918	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chrX:12632918C>A	uc004cuz.1	+	4	846	c.340C>A	c.(340-342)CTG>ATG	p.L114M	FRMPD4_uc011mij.1_Missense_Mutation_p.L106M	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	114	PDZ.				positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						TGAAGGCAAGCTGATCCCGGG	0.512			NA											15	92					0.000308642	0.000367996	0.003163	1	0
SCML2	10389	broad.mit.edu	37	X	18264732	18264732	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chrX:18264732T>A	uc004cyl.2	-	13	1944	c.1787A>T	c.(1786-1788)CAT>CTT	p.H596L	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Missense_Mutation_p.H596L|SCML2_uc011miz.1_Missense_Mutation_p.H530L|SCML2_uc010nfc.2_Missense_Mutation_p.H332L	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	596					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)					TTTAACTTCATGGGGACTGCT	0.413	Esophageal Squamous(100;1252 1965 19021 35517)		NA											19	93					0	0	0.007413	0	0
CXorf22	170063	broad.mit.edu	37	X	35971801	35971801	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chrX:35971801G>A	uc004ddj.2	+	7	1198	c.1139G>A	c.(1138-1140)GGA>GAA	p.G380E	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	380										large_intestine(1)|lung(1)|ovary(1)	3						AGTAAAGATGGATTTTTGAGA	0.318			NA											11	62					0	0	0.000978	0	0
IRS4	8471	broad.mit.edu	37	X	107977758	107977758	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chrX:107977758C>A	uc004eoc.2	-	1	1850	c.1817G>T	c.(1816-1818)CGT>CTT	p.R606L		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	606						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						AGATTTTCCACGTTCACCATC	0.542			NA											35	154					1.04352e-10	1.55275e-10	0.003755	1	0
MST4	51765	broad.mit.edu	37	X	131197485	131197485	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chrX:131197485G>T	uc004ewk.1	+	4	599	c.298G>T	c.(298-300)GAA>TAA	p.E100*	MST4_uc004ewl.1_Nonsense_Mutation_p.E23*|MST4_uc011mux.1_Nonsense_Mutation_p.E122*|MST4_uc010nrj.1_Nonsense_Mutation_p.E100*|MST4_uc004ewm.1_Nonsense_Mutation_p.E100*	NM_016542	NP_057626	Q9P289	MST4_HUMAN	serine/threonine protein kinase MST4 isoform 1	100	Protein kinase.				cellular component disassembly involved in apoptosis|regulation of apoptosis	cytosol|Golgi membrane	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(3)|stomach(2)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(192;0.000127)					GATAATAATGGAATACCTGGG	0.323			NA											16	109					0.00074312	0.000858512	0.006122	1	0
RENBP	5973	broad.mit.edu	37	X	153209788	153209788	+	Missense_Mutation	SNP	A	A	C			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chrX:153209788A>C	uc004fjo.1	-	2	280	c.110T>G	c.(109-111)ATG>AGG	p.M37R	RENBP_uc011mzh.1_Missense_Mutation_p.M37R|RENBP_uc011mzi.1_5'Flank	NM_002910	NP_002901	P51606	RENBP_HUMAN	renin binding protein	37					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			ovary(1)|pancreas(1)	2	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	GGAGTGCTCCATCCAGAAAGC	0.622			NA											14	83					0	0	0.003163	0	0
KLHL28	54813	broad.mit.edu	37	14	45414728	45414728	+	Frame_Shift_Del	DEL	C	C	-			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr14:45414728delC	uc001wvq.2	-	2	650	c.404delG	c.(403-405)GGTfs	p.G135fs	KLHL28_uc001wvr.2_Frame_Shift_Del_p.G135fs|KLHL28_uc001wvt.3_Frame_Shift_Del_p.G135fs	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	135										ovary(1)	1						AATACAATTACCAGGATCAAG	0.408			NA											9	62	---	---	---	---	NA	NA	NA	NA	NA
HOXB8	3218	broad.mit.edu	37	17	46690610	46690611	+	Frame_Shift_Ins	INS	-	-	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr17:46690610_46690611insA	uc002inw.2	-	2	920_921	c.685_686insT	c.(685-687)CCAfs	p.P229fs	HOXB7_uc002inv.2_5'Flank	NM_024016	NP_076921	P17481	HXB8_HUMAN	homeobox B8	229						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CGCCGCCTCTGGGGCCCGCTCC	0.485			NA											23	120	---	---	---	---	NA	NA	NA	NA	NA
ACTR2	10097	broad.mit.edu	37	2	65473856	65473859	+	Frame_Shift_Del	DEL	AGAG	AGAG	-			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	AGAG	AGAG	-	-	AGAG	AGAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr2:65473856_65473859delAGAG	uc002sdq.2	+	3	573_576	c.358_361delAGAG	c.(358-363)AGAGAGfs	p.R120fs	ACTR2_uc010yqf.1_Frame_Shift_Del_p.R65fs|ACTR2_uc002sdp.2_Frame_Shift_Del_p.R125fs|ACTR2_uc010yqg.1_Frame_Shift_Del_p.R68fs	NM_005722	NP_005713	P61160	ARP2_HUMAN	actin-related protein 2 isoform b	120_121					cellular component movement	Arp2/3 protein complex|cell projection|cytoplasm	actin binding|ATP binding				0						AACCAAAAACAGAGAGAAGATTGT	0.338			NA											9	130	---	---	---	---	NA	NA	NA	NA	NA
SIK1	150094	broad.mit.edu	37	21	44841183	44841184	+	Frame_Shift_Ins	INS	-	-	G			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr21:44841183_44841184insG	uc002zdf.2	-	6	690_691	c.563_564insC	c.(562-564)CCGfs	p.P188fs		NM_173354	NP_775490	P57059	SIK1_HUMAN	salt-inducible kinase 1	188	Protein kinase.				anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|testis(2)|ovary(1)|central_nervous_system(1)|skin(1)	7						GGGCGGCATACGGGGGGCTCCC	0.589			NA											16	92	---	---	---	---	NA	NA	NA	NA	NA
MACC1	346389	broad.mit.edu	37	7	20198725	20198726	+	Frame_Shift_Ins	INS	-	-	A			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr7:20198725_20198726insA	uc003sus.3	-	5	1567_1568	c.1258_1259insT	c.(1258-1260)TGGfs	p.W420fs	MACC1_uc010kug.2_Frame_Shift_Ins_p.W420fs	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	420					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						CTGCTTCCCCCAGAGCTGAAAC	0.356			NA											8	52	---	---	---	---	NA	NA	NA	NA	NA
PIK3CG	5294	broad.mit.edu	37	7	106509606	106509606	+	Frame_Shift_Del	DEL	C	C	-			TCGA-49-4506-01A-01D-1265-08	TCGA-49-4506-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d707f8ad-5ea5-493a-a745-9b5dba64f213	b8fa1b54-140b-4a50-bc72-604fe25b0f32	g.chr7:106509606delC	uc003vdv.3	+	2	1685	c.1600delC	c.(1600-1602)CCCfs	p.P534fs	PIK3CG_uc003vdu.2_Frame_Shift_Del_p.P534fs|PIK3CG_uc003vdw.2_Frame_Shift_Del_p.P534fs	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	534					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						TAAGCATCAGCCCACCCCTGA	0.537			NA											19	68	---	---	---	---	NA	NA	NA	NA	NA
