Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PLCH2	9651	broad.mit.edu	37	1	2430207	2430207	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:2430207G>A	uc001aji.1	+	18	2648	c.2374G>A	c.(2374-2376)GAG>AAG	p.E792K	PLCH2_uc010nyz.1_Missense_Mutation_p.E580K|PLCH2_uc009vle.1_Missense_Mutation_p.E544K|PLCH2_uc001ajj.1_Missense_Mutation_p.E580K|PLCH2_uc001ajk.1_Missense_Mutation_p.E580K|PLCH2_uc001ajl.1_5'UTR	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	792	C2.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		TGTGGAGGTGGAGATCATTGG	0.672			NA											4	10					0	0	0.000602	0	0
GPR153	387509	broad.mit.edu	37	1	6313832	6313832	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:6313832G>A	uc001amp.1	-	3	992	c.732C>T	c.(730-732)GGC>GGT	p.G244G		NM_207370	NP_997253	Q6NV75	GP153_HUMAN	G protein-coupled receptor 153	244	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0	Ovarian(185;0.0634)	all_cancers(23;8.07e-33)|all_epithelial(116;4.45e-18)|all_lung(118;1.09e-06)|all_neural(13;3.68e-06)|Lung NSC(185;1.52e-05)|all_hematologic(16;2.39e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00475)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;1.91e-37)|GBM - Glioblastoma multiforme(13;4.87e-29)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;1.33e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.246)		TGGTCACGAGGCCCGTGGTCT	0.652			NA											9	30					0	0	0.006214	0	0
VPS13D	55187	broad.mit.edu	37	1	12337880	12337880	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:12337880C>A	uc001atv.2	+	19	4376	c.4235C>A	c.(4234-4236)GCG>GAG	p.A1412E	VPS13D_uc001atw.2_Missense_Mutation_p.A1412E|VPS13D_uc001atx.2_Missense_Mutation_p.A600E	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	1412					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AATTTTGTGGCGGGAGATGAT	0.458			NA											3	80					0.00909568	0.00968112	0.009096	1	0
HSPB7	27129	broad.mit.edu	37	1	16343586	16343586	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:16343586C>A	uc001axo.2	-	2	1143	c.316G>T	c.(316-318)GAG>TAG	p.E106*	HSPB7_uc001axp.2_Nonsense_Mutation_p.E194*|HSPB7_uc001axq.2_Nonsense_Mutation_p.E198*|HSPB7_uc001axr.2_Nonsense_Mutation_p.E199*|HSPB7_uc001axs.2_Nonsense_Mutation_p.E181*|CLCNKA_uc001axt.2_5'Flank	NM_014424	NP_055239	Q9UBY9	HSPB7_HUMAN	cardiovascular heat shock protein	106					regulation of heart contraction|response to heat|response to unfolded protein	Cajal body	protein C-terminus binding				0		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.21e-08)|COAD - Colon adenocarcinoma(227;5.5e-06)|BRCA - Breast invasive adenocarcinoma(304;9.08e-05)|Kidney(64;0.000162)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00656)|READ - Rectum adenocarcinoma(331;0.0649)		GCCCGCACCTCGATGTGGTTG	0.562			NA											40	62					1.03484e-13	1.56263e-13	0.005524	1	0
RAP1GAP	5909	broad.mit.edu	37	1	21936680	21936680	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:21936680G>A	uc001bex.2	-	14	1190	c.932C>T	c.(931-933)TCC>TTC	p.S311F	RAP1GAP_uc001bev.2_Missense_Mutation_p.S311F|RAP1GAP_uc001bew.2_Missense_Mutation_p.S375F|RAP1GAP_uc001bey.2_Missense_Mutation_p.S311F	NM_002885	NP_002876	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein isoform c	311	Rap-GAP.				regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		CAGGAAGTTGGACGCGATCAT	0.622			NA											10	49					0	0	0.008291	0	0
MYOM3	127294	broad.mit.edu	37	1	24383886	24383886	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:24383886C>A	uc001bin.3	-	37	4445	c.4282G>T	c.(4282-4284)GGG>TGG	p.G1428W	MYOM3_uc001bil.3_Missense_Mutation_p.G321W|MYOM3_uc001bim.3_Missense_Mutation_p.G1085W	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	1428										skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GGCTCGTCCCCGTGCTTGAAC	0.567			NA											17	26					3.32936e-07	4.20355e-07	0.006122	1	0
CSMD2	114784	broad.mit.edu	37	1	34238194	34238194	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:34238194A>T	uc001bxn.1	-	13	1731	c.1702T>A	c.(1702-1704)TCG>ACG	p.S568T	CSMD2_uc001bxm.1_Missense_Mutation_p.S608T	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	568	Sushi 3.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TTCTTAGCCGACCATTGGTTA	0.577			NA											44	67					0	0	0.01441	0	0
DLGAP3	58512	broad.mit.edu	37	1	35365842	35365842	+	Silent	SNP	G	G	T	rs149715442		TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:35365842G>T	uc001byc.2	-	2	1140	c.1140C>A	c.(1138-1140)ACC>ACA	p.T380T		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	380					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				CCTTGCCACCGGTGGGGTAAC	0.612			NA											14	87					4.14922e-12	5.93496e-12	0.004007	1	0
KIAA0319L	79932	broad.mit.edu	37	1	35940490	35940490	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:35940490C>A	uc001byx.2	-	5	1189	c.931G>T	c.(931-933)GTA>TTA	p.V311L	KIAA0319L_uc010ohw.1_RNA|KIAA0319L_uc001byz.2_Missense_Mutation_p.V311L|KIAA0319L_uc010ohx.1_Missense_Mutation_p.V311L	NM_024874	NP_079150	Q8IZA0	K319L_HUMAN	dyslexia susceptibility 2-like	311	Extracellular (Potential).					cytoplasmic vesicle part|integral to membrane	protein binding			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CCAGCAGATACCACCAGTTCC	0.373			NA											13	64					5.50884e-06	6.54114e-06	0.013537	1	0
RSPO1	284654	broad.mit.edu	37	1	38082184	38082184	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:38082184G>T	uc001cbl.1	-	5	1046	c.258C>A	c.(256-258)GCC>GCA	p.A86A	RSPO1_uc001cbm.1_Silent_p.A86A|RSPO1_uc009vvf.1_Silent_p.A59A|RSPO1_uc009vvg.1_Silent_p.A86A	NM_001038633	NP_001033722	Q2MKA7	RSPO1_HUMAN	R-spondin1 precursor	86					positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CGGGGTTGCGGGCGTCGAAGT	0.612	GBM(122;680 2230 27822 42821)		NA											21	32					3.51602e-12	5.05055e-12	0.008871	1	0
C1orf109	54955	broad.mit.edu	37	1	38155361	38155361	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:38155361C>A	uc001cbp.2	-	2	382	c.192G>T	c.(190-192)CGG>CGT	p.R64R	C1orf109_uc010oig.1_Silent_p.R127R|C1orf109_uc001cbo.2_Silent_p.R126R|C1orf109_uc001cbq.1_Silent_p.R64R|CDCA8_uc001cbr.2_5'Flank|CDCA8_uc001cbs.2_5'Flank	NM_017850	NP_060320	Q9NX04	CA109_HUMAN	hypothetical protein LOC54955	64											0		Myeloproliferative disorder(586;0.0393)				CTGGGAAGGCCCGAAGCGCCG	0.622			NA											18	75					0.006122	0.00656759	0.006122	1	0
FAM183A	440585	broad.mit.edu	37	1	43616454	43616454	+	Silent	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:43616454C>T	uc009vwo.2	+	2	185	c.156C>T	c.(154-156)CCC>CCT	p.P52P		NM_001101376	NP_001094846	A6NL82	F183A_HUMAN	hCG23177	52								p.P52P(1)		ovary(3)	3						CCAGGAAGCCCATGTCTTGGC	0.468			NA											6	16					0	0	0.001168	0	0
BSND	7809	broad.mit.edu	37	1	55474247	55474247	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:55474247C>A	uc001cye.2	+	4	1152	c.909C>A	c.(907-909)GCC>GCA	p.A303A		NM_057176	NP_476517	Q8WZ55	BSND_HUMAN	barttin	303	Cytoplasmic (Potential).					basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				ovary(1)|skin(1)	2						CAGATGGAGCCGGGGACCTCC	0.582	Ovarian(191;1657 2078 22894 42033 48899)		NA											18	60					1.28384e-07	1.63925e-07	0.012319	1	0
C8A	731	broad.mit.edu	37	1	57372457	57372457	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:57372457G>T	uc001cyo.2	+	8	1346	c.1214G>T	c.(1213-1215)GGC>GTC	p.G405V		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	405	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						TTTGGAGGTGGCAAAACTGGC	0.408			NA											25	48					4.47668e-21	7.47583e-21	0.003954	1	0
C8B	732	broad.mit.edu	37	1	57417726	57417726	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:57417726G>T	uc001cyp.2	-	5	728	c.661C>A	c.(661-663)CCA>ACA	p.P221T	C8B_uc010oon.1_Missense_Mutation_p.P159T|C8B_uc010ooo.1_Missense_Mutation_p.P169T	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	221	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						ctTACCTGTGGCGTGTAGCTT	0.279			NA											25	44					1.55469e-16	2.49192e-16	0.00333	1	0
LEPR	3953	broad.mit.edu	37	1	66070859	66070859	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:66070859G>T	uc001dci.2	+	11	1744	c.1542G>T	c.(1540-1542)AGG>AGT	p.R514S	LEPR_uc001dcg.2_Missense_Mutation_p.R514S|LEPR_uc001dch.2_Missense_Mutation_p.R514S|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Missense_Mutation_p.R514S|LEPR_uc001dck.2_Missense_Mutation_p.R514S	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	514	Extracellular (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TGTGGATTAGGATCAATCACT	0.423			NA											37	99					9.45814e-24	1.63171e-23	0.004878	1	0
SGIP1	84251	broad.mit.edu	37	1	67206396	67206396	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:67206396G>A	uc001dcr.2	+	23	2507	c.2290G>A	c.(2290-2292)GAA>AAA	p.E764K	SGIP1_uc010opd.1_Missense_Mutation_p.E364K|SGIP1_uc001dcs.2_Missense_Mutation_p.E364K|SGIP1_uc001dct.2_Missense_Mutation_p.E366K|SGIP1_uc009wat.2_Missense_Mutation_p.E558K|SGIP1_uc001dcu.2_Missense_Mutation_p.E269K	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	764					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						TCAGAAGTCAGAAAATGGAGG	0.308			NA											6	30					0	0	0.00308	0	0
RPE65	6121	broad.mit.edu	37	1	68910296	68910296	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:68910296G>T	uc001dei.1	-	5	467	c.413C>A	c.(412-414)CCA>CAA	p.P138Q		NM_000329	NP_000320	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein	138					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			ovary(1)	1						TTCCCCCACTGGGTAGACATT	0.403			NA											25	57					5.45024e-15	8.51443e-15	0.00333	1	0
ELTD1	64123	broad.mit.edu	37	1	79470904	79470904	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:79470904A>T	uc001diq.3	-	2	179	c.23T>A	c.(22-24)GTG>GAG	p.V8E		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	8					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		GGAAAAAACCACTAAATAAAA	0.318			NA											3	15					0	0	0.004672	0	0
GBP4	115361	broad.mit.edu	37	1	89651052	89651052	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:89651052T>C	uc001dnb.2	-	11	1924	c.1808A>G	c.(1807-1809)GAA>GGA	p.E603G		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	603	Potential.					cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		CCTTAACTGTTCATTTTTAGT	0.343			NA											13	47					0	0	0.013537	0	0
BRDT	676	broad.mit.edu	37	1	92445140	92445140	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:92445140G>A	uc001dok.3	+	8	1462	c.1113G>A	c.(1111-1113)ACG>ACA	p.T371T	BRDT_uc001dol.3_Silent_p.T371T|BRDT_uc010osz.1_Silent_p.T375T|BRDT_uc009wdf.2_Silent_p.T298T|BRDT_uc010ota.1_Silent_p.T325T|BRDT_uc010otb.1_Silent_p.T325T|BRDT_uc001dom.3_Silent_p.T371T	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	371					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		TTTTCGAAACGCATTTTTCAA	0.323			NA											14	37					0	0	0.00245	0	0
LPPR4	9890	broad.mit.edu	37	1	99771956	99771956	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:99771956C>T	uc001dse.2	+	7	1788	c.1682C>T	c.(1681-1683)GCT>GTT	p.A561V	LPPR4_uc010oue.1_Missense_Mutation_p.A503V	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	561							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TTAAAAGCTGCTGAAAAGACT	0.547			NA											14	66					0	0	0.00245	0	0
AGL	178	broad.mit.edu	37	1	100382210	100382210	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:100382210G>T	uc001dsi.1	+	33	4804	c.4404G>T	c.(4402-4404)TTG>TTT	p.L1468F	AGL_uc001dsj.1_Missense_Mutation_p.L1468F|AGL_uc001dsk.1_Missense_Mutation_p.L1468F|AGL_uc001dsl.1_Missense_Mutation_p.L1468F|AGL_uc001dsm.1_Missense_Mutation_p.L1452F|AGL_uc001dsn.1_Missense_Mutation_p.L1451F	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	1468	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TTTCCAGATTGATGGGCCCGG	0.348			NA											12	45					0.000978159	0.00108188	0.010729	1	0
COL11A1	1301	broad.mit.edu	37	1	103474073	103474073	+	Splice_Site	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:103474073C>A	uc001dul.2	-	15	1948	c.1630_splice	c.e15-1	p.G544_splice	COL11A1_uc001duk.2_Splice_Site|COL11A1_uc001dum.2_Splice_Site_p.G556_splice|COL11A1_uc001dun.2_Splice_Site_p.G505_splice|COL11A1_uc009weh.2_Splice_Site_p.G428_splice	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A						collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CAGGCCCCCCCTATAGAGAAA	0.303			NA											8	52					0.00448238	0.00483156	0.004482	1	0
SLC16A1	6566	broad.mit.edu	37	1	113471717	113471717	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:113471717C>T	uc001ecx.2	-	2	1046	c.214G>A	c.(214-216)GGA>AGA	p.G72R	SLC16A1_uc001ecy.2_Missense_Mutation_p.G72R|SLC16A1_uc001ecz.2_Missense_Mutation_p.G72R	NM_003051	NP_003042	P53985	MOT1_HUMAN	solute carrier family 16, member 1	72	Helical; (Potential).				blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	TACTTACCTCCACCATACATG	0.378			NA											4	25					0	0	0.009096	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144882775	144882775	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:144882775C>A	uc001elw.3	-	24	3535	c.3244G>T	c.(3244-3246)GTG>TTG	p.V1082L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Splice_Site_p.E1147_splice|PDE4DIP_uc001elv.3_Missense_Mutation_p.V89L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1082					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCAACCATCACCTCGCCCTTC	0.502			NA	T	PDGFRB	MPD								75	534					1.14856e-27	2.04928e-27	0.01441	1	0
C1orf54	79630	broad.mit.edu	37	1	150252073	150252073	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:150252073C>T	uc001eud.2	+	5	358	c.320C>T	c.(319-321)GCC>GTC	p.A107V	C1orf54_uc001euc.2_Missense_Mutation_p.A108V|C1orf54_uc001eue.2_Intron|C1orf54_uc001euf.2_Missense_Mutation_p.A107V|C1orf54_uc001eug.2_Intron|C1orf51_uc001euh.2_5'Flank|C1orf51_uc001eui.2_5'Flank	NM_024579	NP_078855	Q8WWF1	CA054_HUMAN	hypothetical protein LOC79630 precursor	107						extracellular region					0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTGAACGATGCCGTGTCCAGT	0.522			NA											6	871					0	0	0.001984	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150531542	150531542	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:150531542G>A	uc001eux.2	+	16	2900	c.2664G>A	c.(2662-2664)GGG>GGA	p.G888G	ADAMTSL4_uc009wlw.2_Silent_p.G911G|ADAMTSL4_uc010pcg.1_Silent_p.G849G|ADAMTSL4_uc009wlx.2_Silent_p.G51G	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	888	TSP type-1 4.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CAGGAACTGGGCAGAGCTGTC	0.692			NA											6	52					0	0	0.001984	0	0
HRNR	388697	broad.mit.edu	37	1	152187706	152187706	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:152187706G>A	uc001ezt.1	-	3	6475	c.6399C>T	c.(6397-6399)TAC>TAT	p.Y2133Y		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2133					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGTGTTGTCCGTAGCCAGAGG	0.567			NA											40	604					0	0	0.01441	0	0
CD1D	912	broad.mit.edu	37	1	158152695	158152695	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:158152695G>T	uc001frr.2	+	5	1134	c.635G>T	c.(634-636)GGC>GTC	p.G212V	CD1D_uc009wss.2_Intron	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	212	Ig-like.|Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					CTGTCCCGTGGCCCCAGTCCT	0.572			NA											37	77					3.62531e-18	5.95147e-18	0.004289	1	0
SPTA1	6708	broad.mit.edu	37	1	158650416	158650416	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:158650416C>A	uc001fst.1	-	5	834	c.635G>T	c.(634-636)GGG>GTG	p.G212V		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	212	Spectrin 3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					AACAACTCTCCCTTCTTTAGC	0.463			NA											48	85					2.01872e-29	3.62087e-29	0.01441	1	0
PYHIN1	149628	broad.mit.edu	37	1	158911940	158911940	+	Missense_Mutation	SNP	T	T	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:158911940T>G	uc001ftb.2	+	5	998	c.753T>G	c.(751-753)CAT>CAG	p.H251Q	PYHIN1_uc001ftc.2_Missense_Mutation_p.H242Q|PYHIN1_uc001ftd.2_Missense_Mutation_p.H251Q|PYHIN1_uc001fte.2_Missense_Mutation_p.H242Q	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	251	HIN-200.				cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					AGTTCTTTCATGTGAAGGTTT	0.323			NA											11	18					0	0	0.013537	0	0
LY9	4063	broad.mit.edu	37	1	160784336	160784336	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:160784336C>A	uc001fwu.2	+	4	907	c.857C>A	c.(856-858)ACA>AAA	p.T286K	LY9_uc010pjs.1_Missense_Mutation_p.T286K|LY9_uc001fwv.2_Missense_Mutation_p.T286K|LY9_uc001fww.2_Missense_Mutation_p.T286K|LY9_uc001fwx.2_Missense_Mutation_p.T286K|LY9_uc001fwy.1_Missense_Mutation_p.T188K|LY9_uc001fwz.2_5'UTR	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	286	Extracellular (Potential).|Ig-like V-type 2.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TTGTTTAACACATCCATCATT	0.552			NA											28	56					3.73148e-12	5.34871e-12	0.007291	1	0
OLFML2B	25903	broad.mit.edu	37	1	161953798	161953798	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:161953798G>T	uc001gbu.2	-	8	2344	c.1920C>A	c.(1918-1920)GGC>GGA	p.G640G	OLFML2B_uc001gbt.2_Silent_p.G123G|OLFML2B_uc010pkq.1_Silent_p.G641G	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	640	Olfactomedin-like.									skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			CCTGGCTGAAGCCCTCATCGT	0.617			NA											5	39					8.12818e-05	9.26203e-05	0.001984	1	0
ANKRD45	339416	broad.mit.edu	37	1	173616126	173616126	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:173616126C>A	uc001gja.1	-	3	416	c.355G>T	c.(355-357)GCC>TCC	p.A119S		NM_198493	NP_940895	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	135	ANK 2.										0						CGACCCCAGGCTGCAGCACAA	0.423			NA											27	34					0.000147802	0.000168137	0.00632	1	0
SERPINC1	462	broad.mit.edu	37	1	173878765	173878765	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:173878765C>T	uc001gjt.2	-	5	1197	c.1078G>A	c.(1078-1080)GGC>AGC	p.G360S		NM_000488	NP_000479	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C, member 1	360					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(1)	1					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	AAACTGAAGCCGTCCTCAATG	0.542			NA											26	138					0	0	0.00632	0	0
TNR	7143	broad.mit.edu	37	1	175365812	175365813	+	Missense_Mutation	DNP	GG	GG	CT			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:175365812_175365813GG>CT	uc001gkp.1	-	3	1188_1189	c.1107_1108CC>AG	c.(1105-1110)CTCCAG>CTAGAG	p.Q370E	TNR_uc009wwu.1_Missense_Mutation_p.Q370E|TNR_uc010pmz.1_Missense_Mutation_p.P335R	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	370	Fibronectin type-III 1.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					ACCCGCTGCTGGAGCTGGAGGC	0.589			NA											7	60					0	0	0.004672	0	0
TPR	7175	broad.mit.edu	37	1	186344160	186344160	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:186344160T>A	uc001grv.2	-	1	298	c.1A>T	c.(1-3)ATG>TTG	p.M1L	C1orf27_uc001grw.2_5'Flank|C1orf27_uc010poq.1_5'Flank|C1orf27_uc010por.1_5'Flank|TPR_uc010pop.1_Missense_Mutation_p.M77L	NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	1					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		ACCGCCGCCATGTCGGTGGGG	0.622			NA	T	NTRK1	papillary thyroid								6	34					0	0	0.001168	0	0
KCNT2	343450	broad.mit.edu	37	1	196274434	196274434	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:196274434G>T	uc001gtd.1	-	22	2585	c.2525C>A	c.(2524-2526)CCC>CAC	p.P842H	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.P768H|KCNT2_uc001gtf.1_Missense_Mutation_p.P818H|KCNT2_uc001gtg.1_Intron|KCNT2_uc009wyu.2_Missense_Mutation_p.P818H|KCNT2_uc001gth.1_Missense_Mutation_p.P339H	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	842	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CATGTTGGCGGGGTGAGTTAG	0.358			NA											26	35					1.2476e-16	2.00444e-16	0.00632	1	0
DENND1B	163486	broad.mit.edu	37	1	197522226	197522226	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:197522226A>T	uc001guf.3	-	16	1504	c.1166T>A	c.(1165-1167)CTG>CAG	p.L389Q	DENND1B_uc010ppe.1_Missense_Mutation_p.L369Q|DENND1B_uc010ppf.1_Intron|DENND1B_uc001gue.3_Missense_Mutation_p.L359Q	NM_144977	NP_659414	Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B isoform 2	389						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity				0						TAGTTTTGCCAGTCGACCATC	0.299			NA											25	47					0	0	0.00278	0	0
PTPRC	5788	broad.mit.edu	37	1	198668779	198668779	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:198668779G>T	uc001gur.1	+	5	559	c.379G>T	c.(379-381)GGC>TGC	p.G127C	PTPRC_uc001gus.1_Missense_Mutation_p.G127C|PTPRC_uc001gut.1_Intron|PTPRC_uc009wze.1_Missense_Mutation_p.G63C|PTPRC_uc009wzf.1_Missense_Mutation_p.G63C|PTPRC_uc010ppg.1_Missense_Mutation_p.G63C|PTPRC_uc001guu.1_Missense_Mutation_p.G170C|PTPRC_uc001guv.1_RNA|PTPRC_uc001guw.1_RNA	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	127	Extracellular (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						GACATTCAGCGGCTCCGCCGC	0.532			NA									OREG0014061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	134					1.3612e-06	1.66588e-06	0.003163	1	0
KDM5B	10765	broad.mit.edu	37	1	202702652	202702652	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:202702652C>A	uc001gyf.2	-	23	3902	c.3786G>T	c.(3784-3786)TGG>TGT	p.W1262C	KDM5B_uc009xag.2_Missense_Mutation_p.W1298C|KDM5B_uc001gyg.1_Missense_Mutation_p.W1104C	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	1262					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						CTCTGTGCTGCCAGTTCACGG	0.502			NA											18	107					4.96729e-08	6.42714e-08	0.008871	1	0
LAX1	54900	broad.mit.edu	37	1	203743121	203743121	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:203743121C>T	uc001haa.2	+	5	919	c.509C>T	c.(508-510)TCG>TTG	p.S170L	LAX1_uc010pql.1_Missense_Mutation_p.S154L|LAX1_uc001hab.2_Missense_Mutation_p.S94L	NM_017773	NP_060243	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1 isoform a	170	Cytoplasmic (Potential).				B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding			central_nervous_system(2)	2	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CTCACTCCCTCGGCACACTGC	0.532			NA											38	45					0	0	0.004878	0	0
CNTN2	6900	broad.mit.edu	37	1	205036280	205036281	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:205036280_205036281CC>AT	uc001hbr.2	+	16	2296_2297	c.2027_2028CC>AT	c.(2026-2028)ACC>AAT	p.T676N	CNTN2_uc001hbq.1_Missense_Mutation_p.T567N|CNTN2_uc001hbs.2_Missense_Mutation_p.T464N	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	676	Fibronectin type-III 1.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CTGGGCCTCACCCCCTGGATGG	0.579	Melanoma(183;2548 2817 37099 41192)		NA											5	63					0	0	0.004672	0	0
DTL	51514	broad.mit.edu	37	1	212245479	212245479	+	Missense_Mutation	SNP	A	A	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:212245479A>C	uc009xdc.2	+	11	1273	c.959A>C	c.(958-960)TAT>TCT	p.Y320S	DTL_uc010ptb.1_Missense_Mutation_p.Y278S|DTL_uc001hiz.3_Missense_Mutation_p.Y49S	NM_016448	NP_057532	Q9NZJ0	DTL_HUMAN	denticleless homolog	320	WD 6.				DNA replication|G2/M transition DNA damage checkpoint|protein monoubiquitination|protein polyubiquitination|response to UV|translesion synthesis|ubiquitin-dependent protein catabolic process	centrosome|Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|nuclear membrane	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00796)|all cancers(67;0.0385)|Epithelial(68;0.102)		TCTACCTTTTATGTAAAATCC	0.398			NA											6	85					0	0	0.001984	0	0
ESRRG	2104	broad.mit.edu	37	1	216737622	216737622	+	Silent	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:216737622T>A	uc001hkw.1	-	5	967	c.801A>T	c.(799-801)ACA>ACT	p.T267T	ESRRG_uc001hky.1_Silent_p.T244T|ESRRG_uc009xdp.1_Silent_p.T244T|ESRRG_uc001hkz.1_Silent_p.T205T|ESRRG_uc010puc.1_Silent_p.T244T|ESRRG_uc001hla.1_Silent_p.T244T|ESRRG_uc001hlb.1_Silent_p.T244T|ESRRG_uc010pud.1_Silent_p.T75T|ESRRG_uc001hlc.1_Silent_p.T244T|ESRRG_uc001hld.1_Silent_p.T244T|ESRRG_uc001hkx.1_Silent_p.T279T|ESRRG_uc009xdo.1_Silent_p.T244T|ESRRG_uc001hle.1_Silent_p.T244T	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	267					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	AGTCACACAGTGTAGTGAGGG	0.458			NA											7	59					0	0	0.001984	0	0
LYST	1130	broad.mit.edu	37	1	235969162	235969162	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:235969162T>C	uc001hxj.2	-	6	3449	c.3274A>G	c.(3274-3276)ACA>GCA	p.T1092A	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.T1092A	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	1092					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TCTTGACTTGTAAATAGCTTT	0.418			NA							Chediak-Higashsyndrome				10	73					0	0	0.006214	0	0
RYR2	6262	broad.mit.edu	37	1	237944870	237944870	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:237944870C>A	uc001hyl.1	+	89	12006	c.11886C>A	c.(11884-11886)TCC>TCA	p.S3962S	RYR2_uc010pya.1_Silent_p.S377S	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3962					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTCAGGATTCCAGTCAAATTG	0.338			NA											6	9					3.59834e-05	4.1491e-05	0.001168	1	0
ZP4	57829	broad.mit.edu	37	1	238048492	238048492	+	Silent	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:238048492T>A	uc001hym.2	-	9	1284	c.1284A>T	c.(1282-1284)ACA>ACT	p.T428T	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	428	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GTTTCTCCACTGTAGGGTTCA	0.532	NSCLC(166;160 2029 11600 18754 19936)		NA											24	29					0	0	0.014323	0	0
FMN2	56776	broad.mit.edu	37	1	240497408	240497409	+	Splice_Site	DNP	GG	GG	TT			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:240497408_240497409GG>TT	uc010pyd.1	+	13	4870	c.4645_splice	c.e13-1	p.D1549_splice	FMN2_uc010pye.1_Splice_Site_p.D1553_splice|FMN2_uc010pyf.1_Splice_Site_p.D195_splice|FMN2_uc010pyg.1_Splice_Site_p.D145_splice	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2						actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TTGTTCATTAGGATGCTGGAAA	0.347			NA											58	89					0	0	0.004672	0	0
SDCCAG8	10806	broad.mit.edu	37	1	243652408	243652408	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:243652408G>T	uc001hzw.2	+	17	2234	c.2078G>T	c.(2077-2079)AGC>ATC	p.S693I	SDCCAG8_uc010pyk.1_Missense_Mutation_p.S548I|SDCCAG8_uc010pyl.1_Missense_Mutation_p.S505I|SDCCAG8_uc001hzx.2_Missense_Mutation_p.S426I|AKT3_uc001hzz.1_Intron	NM_006642	NP_006633	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	693	Mediates interaction with OFD1.|Potential.|Sufficient for homodimerization (By similarity).				establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding				0	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		GAGAGGCAGAGCCTGTCGGAA	0.622			NA											8	15					1.12685e-05	1.32181e-05	0.004482	1	0
NLRP3	114548	broad.mit.edu	37	1	247588623	247588623	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:247588623C>A	uc001icr.2	+	5	2016	c.1878C>A	c.(1876-1878)AGC>AGA	p.S626R	NLRP3_uc001ics.2_Missense_Mutation_p.S626R|NLRP3_uc001icu.2_Missense_Mutation_p.S626R|NLRP3_uc001icw.2_Missense_Mutation_p.S626R|NLRP3_uc001icv.2_Missense_Mutation_p.S626R|NLRP3_uc010pyw.1_Missense_Mutation_p.S624R|NLRP3_uc001ict.1_Missense_Mutation_p.S624R	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	626					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TCCAGCCCAGCCAGCTGGAAT	0.463			NA											20	34					0.000175454	0.000197605	0.010504	1	0
NLRP3	114548	broad.mit.edu	37	1	247607377	247607377	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:247607377G>T	uc001icr.2	+	9	2911	c.2773G>T	c.(2773-2775)GGA>TGA	p.G925*	NLRP3_uc001ics.2_Nonsense_Mutation_p.G868*|NLRP3_uc001icu.2_Nonsense_Mutation_p.G925*|NLRP3_uc001icw.2_Nonsense_Mutation_p.G868*|NLRP3_uc001icv.2_Nonsense_Mutation_p.G811*|NLRP3_uc010pyw.1_Nonsense_Mutation_p.G903*	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	925	LRR 7.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CAACACTCTCGGAGACAAGGG	0.493			NA											36	59					6.90743e-12	9.83873e-12	0.003755	1	0
OR2AK2	391191	broad.mit.edu	37	1	248128777	248128777	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:248128777C>A	uc010pzd.1	+	1	144	c.144C>A	c.(142-144)ACC>ACA	p.T48T	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	48	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TCATTGCCACCCTCTTTACAG	0.428	Melanoma(45;390 1181 23848 28461 41504)		NA											24	247					4.26978e-12	6.09454e-12	0.00333	1	0
OR2T33	391195	broad.mit.edu	37	1	248436317	248436317	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:248436317T>A	uc010pzi.1	-	1	800	c.800A>T	c.(799-801)AAC>ATC	p.N267I		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTTGTCATGGTTAGTGGACCT	0.473			NA											33	198					0	0	0.003755	0	0
OR2T4	127074	broad.mit.edu	37	1	248525781	248525781	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:248525781C>A	uc001ieh.1	+	1	899	c.899C>A	c.(898-900)CCT>CAT	p.P300H		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	300	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TACCACACCCCTGAGAAGGAC	0.507			NA											70	130					1.43675e-24	2.49774e-24	0.01441	1	0
OR2T3	343173	broad.mit.edu	37	1	248636972	248636972	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:248636972C>G	uc001iel.1	+	1	321	c.321C>G	c.(319-321)TTC>TTG	p.F107L		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	107	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCCAGATGTTCTTCTACCTGA	0.542			NA											45	63					0	0	0.01441	0	0
TUBB8	347688	broad.mit.edu	37	10	93890	93890	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr10:93890C>A	uc001ifi.2	-	4	442	c.442G>T	c.(442-444)GGT>TGT	p.G148C	TUBB8_uc009xhe.2_Missense_Mutation_p.G111C|TUBB8_uc010pzs.1_Missense_Mutation_p.G76C	NM_177987	NP_817124	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 isoform 1	148					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		AGAAGGGTACCCATCCCAGAC	0.587	Pancreas(192;2041 3010 9013 18103)		NA											27	153					2.12542e-12	3.08572e-12	0.00632	1	0
GATA3	2625	broad.mit.edu	37	10	8100557	8100557	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr10:8100557G>A	uc001ika.2	+	3	1088	c.531G>A	c.(529-531)CGG>CGA	p.R177R	GATA3_uc001ijz.2_Silent_p.R177R	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	177					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						GCTCGGCCCGGCAGGACGAGA	0.701			NA	F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						3	42					0	0	0.004672	0	0
GPR158	57512	broad.mit.edu	37	10	25887427	25887427	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr10:25887427C>A	uc001isj.2	+	11	2932	c.2872C>A	c.(2872-2874)CCC>ACC	p.P958T	GPR158_uc001isk.2_Missense_Mutation_p.P333T	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	958	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						AGATCCTGCCCCCCAAAACTC	0.438			NA											29	66					1.26454e-06	1.55601e-06	0.005443	1	0
SYT15	83849	broad.mit.edu	37	10	46967663	46967663	+	Silent	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr10:46967663T>C	uc001jea.2	-	4	567	c.414A>G	c.(412-414)AAA>AAG	p.K138K	SYT15_uc001jdz.2_Silent_p.K138K|SYT15_uc001jeb.2_Silent_p.K16K|SYT15_uc010qfp.1_RNA	NM_031912	NP_114118	Q9BQS2	SYT15_HUMAN	synaptotagmin XV isoform a	138	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0						CGGTCTCACTTTTGTCCTCCG	0.612	Ovarian(57;1152 1428 19651 37745)		NA											16	175					0	0	0.007413	0	0
OGDHL	55753	broad.mit.edu	37	10	50953477	50953477	+	Nonsense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr10:50953477G>C	uc001jie.2	-	12	1684	c.1542C>G	c.(1540-1542)TAC>TAG	p.Y514*	OGDHL_uc009xog.2_Nonsense_Mutation_p.Y541*|OGDHL_uc010qgt.1_Nonsense_Mutation_p.Y457*|OGDHL_uc010qgu.1_Nonsense_Mutation_p.Y305*|OGDHL_uc009xoh.2_Nonsense_Mutation_p.Y305*	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	514					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						GGATCTGCTTGTACATGAGCG	0.612			NA											8	52					0	0	0.008291	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62648365	62648365	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr10:62648365A>T	uc001jli.2	-	7	1499	c.1061T>A	c.(1060-1062)GTG>GAG	p.V354E	RHOBTB1_uc001jlh.2_Missense_Mutation_p.V354E|RHOBTB1_uc001jlj.2_Missense_Mutation_p.V354E|RHOBTB1_uc001jlk.2_Missense_Mutation_p.V354E|RHOBTB1_uc009xpe.1_Missense_Mutation_p.V292E|RHOBTB1_uc001jll.2_Missense_Mutation_p.V104E	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	354	BTB 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					CAGAGCCTCCACCAGGCTCTT	0.577			NA											58	84					0	0	0.01441	0	0
GRID1	2894	broad.mit.edu	37	10	87379647	87379647	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr10:87379647G>T	uc001kdl.1	-	14	2438	c.2337C>A	c.(2335-2337)CCC>CCA	p.P779P	GRID1_uc009xsu.1_Intron|GRID1_uc010qmf.1_Silent_p.P350P	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	779	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	GGTCCCTGTAGGGGCTGCCAT	0.567			NA								Multiple Myeloma(13;0.14)			13	26					1.5842e-08	2.09374e-08	0.001855	1	0
SEC31B	25956	broad.mit.edu	37	10	102256170	102256170	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr10:102256170T>C	uc001krc.1	-	18	2257	c.2155A>G	c.(2155-2157)ATG>GTG	p.M719V	SEC31B_uc010qpo.1_Missense_Mutation_p.M718V|SEC31B_uc001krd.1_Missense_Mutation_p.M256V|SEC31B_uc001krf.1_Missense_Mutation_p.M256V|SEC31B_uc001kre.1_Missense_Mutation_p.M256V|SEC31B_uc001krg.1_Missense_Mutation_p.M288V	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	719					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		TTAAGAACCATCACCTTCTCC	0.557			NA											9	67					0	0	0.006214	0	0
SLK	9748	broad.mit.edu	37	10	105750539	105750539	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr10:105750539G>C	uc001kxo.1	+	2	291	c.257G>C	c.(256-258)TGT>TCT	p.C86S	SLK_uc001kxp.1_Missense_Mutation_p.C86S	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	86	Protein kinase.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TTAGCATCTTGTGATCACCCA	0.348	NSCLC(111;540 1651 1927 4474 17706)		NA											9	57					0	0	0.006214	0	0
COL17A1	1308	broad.mit.edu	37	10	105794522	105794523	+	Missense_Mutation	DNP	GC	GC	AA			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr10:105794522_105794523GC>AA	uc001kxr.2	-	51	3791_3792	c.3622_3623GC>TT	c.(3622-3624)GCC>TTC	p.A1208F	COL17A1_uc001kxq.2_5'Flank	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	1208	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TGACAAGCCGGCAGCTGGGCAG	0.644			NA											10	36					0	0	0.004672	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118355819	118355819	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr10:118355819C>A	uc001lco.1	+	6	577	c.559C>A	c.(559-561)CTG>ATG	p.L187M	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.L187M|PNLIPRP1_uc009xys.1_RNA	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	187					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		GACTCCAGGCCTGAGCAGGAT	0.582			NA											32	129					2.81731e-10	3.87452e-10	0.010818	1	0
VAX1	11023	broad.mit.edu	37	10	118897512	118897512	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr10:118897512G>C	uc009xyx.2	-	1	301	c.56C>G	c.(55-57)GCC>GGC	p.A19G	VAX1_uc001ldb.1_Missense_Mutation_p.A19G	NM_001112704	NP_001106175	Q5SQQ9	VAX1_HUMAN	ventral anterior homeobox 1 isoform a	19						nucleus	sequence-specific DNA binding			ovary(2)	2				all cancers(201;0.0108)		CGAGACCCGGGCAGCCTCGGC	0.507			NA											9	39					0	0	0.004482	0	0
EIF3A	8661	broad.mit.edu	37	10	120810820	120810820	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr10:120810820T>A	uc001ldu.2	-	15	2356	c.2210A>T	c.(2209-2211)CAG>CTG	p.Q737L	EIF3A_uc010qsu.1_Missense_Mutation_p.Q703L|EIF3A_uc009xzg.1_5'Flank	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	737	Interaction with EIF3B.|Glu-rich.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		ACGTTCTAGCTGCATTGTAGT	0.348			NA											30	66					0	0	0.010818	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133930853	133930853	+	Silent	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr10:133930853G>C	uc001lkx.3	+	2	408	c.408G>C	c.(406-408)CTG>CTC	p.L136L		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		CCGTGCTGCTGTCCGAGGCCA	0.607			NA											11	77					0	0	0.00245	0	0
SYCE1	93426	broad.mit.edu	37	10	135369500	135369500	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr10:135369500G>T	uc001lno.2	-	9	685	c.580C>A	c.(580-582)CAG>AAG	p.Q194K	CYP2E1_uc001lnl.1_3'UTR|SYCE1_uc001lnm.2_Missense_Mutation_p.Q66K|SYCE1_uc009ybn.2_Missense_Mutation_p.Q194K|SYCE1_uc001lnn.2_Missense_Mutation_p.Q158K	NM_001143764	NP_001137236	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	194	Potential.				cell division	central element				ovary(1)	1		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		TTGAGCAGCTGCTCCTTGCTG	0.582			NA											35	64					1.42033e-22	2.4135e-22	0.004289	1	0
MUC5B	727897	broad.mit.edu	37	11	1269244	1269244	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:1269244C>G	uc009ycr.1	+	50	12844	c.12718C>G	c.(12718-12720)CCG>GCG	p.P4240A	MUC5B_uc001ltb.2_Missense_Mutation_p.P3715A	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3712	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CACGGCCACCCCGTCCTCCAC	0.657			NA											41	42					0	0	0.01441	0	0
SYT8	90019	broad.mit.edu	37	11	1857722	1857722	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:1857722G>T	uc001lue.1	+	6	754	c.626G>T	c.(625-627)GGG>GTG	p.G209V	SYT8_uc001lud.2_Missense_Mutation_p.G209V|SYT8_uc001luf.1_Missense_Mutation_p.G195V|TNNI2_uc010qxc.1_5'Flank|TNNI2_uc010qxd.1_5'Flank	NM_138567	NP_612634	Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	209	C2 1.|Cytoplasmic (Potential).					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CGCTTCTCGGGGCATGAGCCC	0.672			NA											9	9					7.93312e-07	9.79719e-07	0.00245	1	0
CHRNA10	57053	broad.mit.edu	37	11	3688774	3688775	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:3688774_3688775CC>AA	uc001lyf.2	-	4	654_655	c.582_583GG>TT	c.(580-585)GCGGAC>GCTTAC	p.D195Y	CHRNA10_uc010qxt.1_5'UTR|CHRNA10_uc010qxu.1_5'UTR	NM_020402	NP_065135	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10	195	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			ovary(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	TCCACGAAGTCCGCCAGGCTGG	0.718	Melanoma(153;17 1869 2949 7120 36888)		NA											3	4					0	0	0.004672	0	0
OR52B4	143496	broad.mit.edu	37	11	4389409	4389409	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:4389409G>A	uc010qye.1	-	1	117	c.117C>T	c.(115-117)ACC>ACT	p.T39T		NM_001005161	NP_001005161	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B,	39	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAAGAAGGGCGGTGACATAGG	0.527			NA											4	33					0	0	0.009096	0	0
OR51D1	390038	broad.mit.edu	37	11	4661968	4661968	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:4661968C>A	uc010qyk.1	+	1	948	c.948C>A	c.(946-948)CTC>CTA	p.L316L		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	316	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAAGGGTCCTCTGTATGTTCT	0.463			NA											32	43					1.62565e-12	2.36521e-12	0.012213	1	0
OR51E1	143503	broad.mit.edu	37	11	4674283	4674283	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:4674283T>C	uc001lzi.3	+	2	671	c.527T>C	c.(526-528)ATC>ACC	p.I176T		NM_152430	NP_689643	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E,	175	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|pancreas(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		CGCTCCAATATCCTTTCCCAT	0.547			NA											58	72					0	0	0.01441	0	0
OR51F2	119694	broad.mit.edu	37	11	4842747	4842747	+	Silent	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:4842747T>A	uc010qyn.1	+	1	132	c.132T>A	c.(130-132)CCT>CCA	p.P44P		NM_001004753	NP_001004753	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F,	44	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTCCATCCCTTTTTGTCTCC	0.483			NA											101	143					0	0	0.01441	0	0
OR51F2	119694	broad.mit.edu	37	11	4843386	4843386	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:4843386C>A	uc010qyn.1	+	1	771	c.771C>A	c.(769-771)TCC>TCA	p.S257S		NM_001004753	NP_001004753	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F,	257	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCTGCACATCCCACATCAGTG	0.498			NA											20	30					8.34094e-07	1.02821e-06	0.008871	1	0
OR51G2	81282	broad.mit.edu	37	11	4936493	4936493	+	Missense_Mutation	SNP	G	G	T	rs148695983		TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:4936493G>T	uc001lzr.1	-	1	401	c.401C>A	c.(400-402)CCC>CAC	p.P134H		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G,	134	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATAGTGCAAGGGGTGGCAGAT	0.488			NA											12	10					2.27111e-07	2.88354e-07	0.013537	1	0
OR51V1	283111	broad.mit.edu	37	11	5221548	5221548	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:5221548G>T	uc010qyz.1	-	1	383	c.383C>A	c.(382-384)GCC>GAC	p.A128D		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	128	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCGGTCAAAGGCCATAGTGAG	0.453			NA											11	24					0.000673444	0.00074607	0.008291	1	0
OR52L1	338751	broad.mit.edu	37	11	6007894	6007894	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:6007894C>A	uc001mcd.2	-	1	322	c.267G>T	c.(265-267)CTG>CTT	p.L89L		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	89	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGCCAGAACCAGGTCGATGG	0.522	Melanoma(121;653 1666 10547 22796 51255)		NA											9	11					7.48243e-07	9.29137e-07	0.006214	1	0
NLRP14	338323	broad.mit.edu	37	11	7083644	7083644	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:7083644T>A	uc001mfb.1	+	10	3208	c.2885T>A	c.(2884-2886)CTG>CAG	p.L962Q		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	962	LRR 9.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		CTGAGGAGCCTGGACCTTGGG	0.423			NA											36	48					0	0	0.004289	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17190358	17190358	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:17190358C>G	uc001mmq.3	-	1	997	c.931G>C	c.(931-933)GAG>CAG	p.E311Q	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Intron|PIK3C2A_uc001mmr.3_RNA|PIK3C2A_uc010rcx.1_Missense_Mutation_p.E311Q|PIK3C2A_uc009ygv.1_Missense_Mutation_p.E311Q	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	311					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	GTCGATCTCTCTTCAAGAAGA	0.393			NA											6	77					0	0	0.001984	0	0
LUZP2	338645	broad.mit.edu	37	11	25004827	25004827	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:25004827G>T	uc001mqs.2	+	9	987	c.753G>T	c.(751-753)GCG>GCT	p.A251A	LUZP2_uc009yif.2_Silent_p.A165A|LUZP2_uc009yig.2_Silent_p.A209A	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	251						extracellular region				ovary(1)|skin(1)	2						CAGATGCAGCGGCCAAAAGCA	0.433			NA											24	33					2.21704e-12	3.20501e-12	0.00278	1	0
PAX6	5080	broad.mit.edu	37	11	31811563	31811563	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:31811563G>T	uc001mtd.3	-	12	2078	c.1188C>A	c.(1186-1188)CTC>CTA	p.L396L	PAX6_uc001mte.3_Silent_p.L396L|PAX6_uc001mtg.3_Silent_p.L410L|PAX6_uc001mtf.3_Silent_p.L396L|PAX6_uc001mth.3_Silent_p.L396L|PAX6_uc009yjr.2_Silent_p.L396L	NM_001127612	NP_001121084	P26367	PAX6_HUMAN	paired box gene 6 isoform a	396	Pro/Ser/Thr-rich.				blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			lung(4)|ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	9	Lung SC(675;0.225)					CAGGGGAAATGAGTCCTAGAA	0.323			NA							Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				12	18					9.31168e-06	1.1018e-05	0.001855	1	0
QSER1	79832	broad.mit.edu	37	11	32956353	32956353	+	Silent	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:32956353A>T	uc001mty.2	+	4	3429	c.3162A>T	c.(3160-3162)GCA>GCT	p.A1054A	QSER1_uc001mtz.1_Silent_p.A815A|QSER1_uc001mua.2_Silent_p.A559A	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1054										ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					CTGGGGATGCAGTCAGTGTCA	0.438			NA											26	26					0	0	0.004656	0	0
NR1H3	10062	broad.mit.edu	37	11	47282902	47282902	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:47282902C>T	uc009ylm.2	+	5	831	c.610C>T	c.(610-612)CCC>TCC	p.P204S	NR1H3_uc009yll.1_Missense_Mutation_p.P210S|NR1H3_uc010rhk.1_Missense_Mutation_p.P210S|NR1H3_uc001nek.2_Missense_Mutation_p.P159S|NR1H3_uc001nej.2_Missense_Mutation_p.P204S|NR1H3_uc001nel.2_Missense_Mutation_p.P159S|NR1H3_uc001nen.3_Missense_Mutation_p.P204S|NR1H3_uc001nem.2_Missense_Mutation_p.P204S|NR1H3_uc001nep.2_Missense_Mutation_p.P113S	NM_005693	NP_005684	Q13133	NR1H3_HUMAN	nuclear receptor subfamily 1, group H, member 3	204					apoptotic cell clearance|cellular response to lipopolysaccharide|cholesterol homeostasis|negative regulation of cholesterol storage|negative regulation of inflammatory response|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of macrophage activation|negative regulation of pancreatic juice secretion|negative regulation of pinocytosis|negative regulation of secretion of lysosomal enzymes|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor biosynthetic process|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of circadian rhythm|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to progesterone stimulus|triglyceride homeostasis	nuclear chromatin|nucleoplasm	cholesterol binding|steroid hormone receptor activity|sterol response element binding|transcription coactivator activity|zinc ion binding			ovary(2)|lung(1)	3						CCAAATCCTGCCCCAGCTCAG	0.597			NA											14	13					0	0	0.00499	0	0
OR4A16	81327	broad.mit.edu	37	11	55110712	55110712	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:55110712C>A	uc010rie.1	+	1	36	c.36C>A	c.(34-36)CTC>CTA	p.L12L		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	12	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						AATTTGTCCTCCTGGGCCTCA	0.388			NA											11	46					1.58986e-06	1.94221e-06	0.008291	1	0
OR4P4	81300	broad.mit.edu	37	11	55406106	55406106	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:55406106C>A	uc010rij.1	+	1	273	c.273C>A	c.(271-273)TCC>TCA	p.S91S		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	91	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						AGACCATTTCCTATAATAACT	0.418			NA											103	125					1.85837e-24	3.22245e-24	0.01441	1	0
OR5L1	219437	broad.mit.edu	37	11	55579446	55579446	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:55579446C>A	uc001nhw.1	+	1	504	c.504C>A	c.(502-504)TTC>TTA	p.F168L		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				GGATCCCCTTCTATAGATCTA	0.458			NA											46	247					6.21074e-16	9.86155e-16	0.011902	1	0
OR8J3	81168	broad.mit.edu	37	11	55904620	55904620	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:55904620G>C	uc010riz.1	-	1	575	c.575C>G	c.(574-576)ACT>AGT	p.T192S		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	192	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					TGGTATGTAAGTATCAGAGCA	0.303			NA											22	120					0	0	0.010504	0	0
OR5T1	390155	broad.mit.edu	37	11	56043707	56043707	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:56043707C>A	uc001nio.1	+	1	593	c.593C>A	c.(592-594)GCT>GAT	p.A198D		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	198	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					CCTCTGCTTGCTATTTCTTGT	0.398			NA											130	173					1.19401e-59	2.224e-59	0.01441	1	0
OR5T1	390155	broad.mit.edu	37	11	56043777	56043777	+	Silent	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:56043777C>G	uc001nio.1	+	1	663	c.663C>G	c.(661-663)GTC>GTG	p.V221V		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	221	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					TTGAGATAGTCACTATCCTGA	0.418			NA											61	216					0	0	0.01441	0	0
OR5M3	219482	broad.mit.edu	37	11	56237320	56237320	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:56237320G>C	uc010rjk.1	-	1	654	c.654C>G	c.(652-654)TTC>TTG	p.F218L		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	218	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					CAATGAGGATGAATAAGTAAG	0.428			NA											10	67					0	0	0.010729	0	0
MS4A14	84689	broad.mit.edu	37	11	60183058	60183058	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:60183058C>A	uc001npj.2	+	5	1182	c.617C>A	c.(616-618)GCT>GAT	p.A206D	MS4A14_uc001npi.2_Missense_Mutation_p.A94D|MS4A14_uc001npn.2_5'UTR|MS4A14_uc001npk.2_Missense_Mutation_p.A189D|MS4A14_uc001npl.2_5'UTR|MS4A14_uc001npm.2_5'UTR	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	206						integral to membrane	receptor activity			breast(1)	1						GGAGGCTATGCTTTCTTCAAG	0.383			NA											23	38					2.32416e-17	3.77885e-17	0.014323	1	0
SLC15A3	51296	broad.mit.edu	37	11	60714150	60714150	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:60714150C>A	uc001nqn.2	-	2	936	c.702G>T	c.(700-702)GTG>GTT	p.V234V	SLC15A3_uc001nqo.2_Silent_p.V234V	NM_016582	NP_057666	Q8IY34	S15A3_HUMAN	solute carrier family 15, member 3	234	Helical; (Potential).				oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity				0						CCACACAGCCCACAGGGATGC	0.562			NA											31	199					4.15321e-07	5.23397e-07	0.009535	1	0
CD6	923	broad.mit.edu	37	11	60783254	60783254	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:60783254A>T	uc001nqq.2	+	9	1680	c.1457A>T	c.(1456-1458)TAT>TTT	p.Y486F	CD6_uc001nqp.2_Missense_Mutation_p.Y486F|CD6_uc001nqr.2_Missense_Mutation_p.Y454F|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Intron	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	486	Cytoplasmic (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						GACTCAGACTATGAGCACTAT	0.627	Pancreas(169;904 2017 4767 38890 42505)		NA											119	70					0	0	0.01441	0	0
AHNAK	79026	broad.mit.edu	37	11	62298829	62298829	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:62298829C>A	uc001ntl.2	-	5	3360	c.3060G>T	c.(3058-3060)GTG>GTT	p.V1020V	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1020					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGGACAGGTTCACATCAAATT	0.463			NA											61	62					1.4709e-25	2.5836e-25	0.01441	1	0
STIP1	10963	broad.mit.edu	37	11	63965045	63965045	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:63965045G>C	uc001nyk.1	+	7	1027	c.880G>C	c.(880-882)GAA>CAA	p.E294Q	STIP1_uc010rnb.1_Missense_Mutation_p.E270Q	NM_006819	NP_006810	P31948	STIP1_HUMAN	stress-induced-phosphoprotein 1	294					axon guidance|response to stress	Golgi apparatus|nucleus				ovary(2)|liver(1)	3						AGAAAACCGAGAAGACTATCG	0.498			NA											7	25					0	0	0.001984	0	0
TM7SF2	7108	broad.mit.edu	37	11	64882402	64882402	+	Silent	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:64882402C>T	uc001oct.2	+	7	888	c.741C>T	c.(739-741)ACC>ACT	p.T247T	TM7SF2_uc010rny.1_Silent_p.T131T|TM7SF2_uc001ocu.2_Silent_p.T247T|TM7SF2_uc001ocv.2_Silent_p.T268T|uc009yqb.1_5'Flank	NM_003273	NP_003264	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	247					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			ovary(1)	1						TCCTCACCACCATGGATATCA	0.617			NA											70	158					0	0	0.01441	0	0
FOSL1	8061	broad.mit.edu	37	11	65664372	65664372	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:65664372T>A	uc001ogg.1	-	2	392	c.205A>T	c.(205-207)ACC>TCC	p.T69S	FOSL1_uc010ros.1_Intron	NM_005438	NP_005429	P15407	FOSL1_HUMAN	FOS-like antigen 1	69					cellular defense response|chemotaxis|positive regulation of cell proliferation|response to virus|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				READ - Rectum adenocarcinoma(159;0.168)		TGAGGGTAGGTCAGAGGCCTG	0.632			NA											24	50					0	0	0.014323	0	0
CD248	57124	broad.mit.edu	37	11	66084155	66084155	+	Missense_Mutation	SNP	G	G	T	rs140616335	byFrequency	TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:66084155G>T	uc001ohm.1	-	1	361	c.344C>A	c.(343-345)ACC>AAC	p.T115N		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	115	C-type lectin.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	GGCCCAGTTGGTGAAAGCCGT	0.716			NA											13	28					1.49906e-05	1.74333e-05	0.00245	1	0
NPAS4	266743	broad.mit.edu	37	11	66189700	66189700	+	Silent	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:66189700C>G	uc001ohx.1	+	2	461	c.285C>G	c.(283-285)CTC>CTG	p.L95L	NPAS4_uc010rpc.1_5'UTR	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	95	PAS 1.				transcription, DNA-dependent		DNA binding|signal transducer activity				0						GGAAATTGCTCTACCTGTCTG	0.597			NA											37	70					0	0	0.011902	0	0
NPAS4	266743	broad.mit.edu	37	11	66189949	66189949	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:66189949A>T	uc001ohx.1	+	3	531	c.355A>T	c.(355-357)ATC>TTC	p.I119F	NPAS4_uc010rpc.1_5'UTR	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	119	PAS 1.				transcription, DNA-dependent		DNA binding|signal transducer activity				0						GGGTGACAGCATCTACGACAT	0.547			NA											28	76					0	0	0.009535	0	0
CARNS1	57571	broad.mit.edu	37	11	67186368	67186368	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:67186368C>G	uc009yrp.2	+	4	589	c.137C>G	c.(136-138)CCG>CGG	p.P46R	PPP1CA_uc001okx.1_Intron|CARNS1_uc010rpq.1_Missense_Mutation_p.P185R|CARNS1_uc010rpr.1_Missense_Mutation_p.P169R|CARNS1_uc001olc.3_Missense_Mutation_p.P185R	NM_020811	NP_065862	A5YM72	CRNS1_HUMAN	ATP-grasp domain containing 1	46					carnosine biosynthetic process		ATP binding|carnosine synthase activity|metal ion binding				0						TTTGTCCCCCCGCGCCGTGCC	0.687			NA											3	16					0	0	0.004672	0	0
PDE2A	5138	broad.mit.edu	37	11	72292014	72292014	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:72292014G>A	uc010rrc.1	-	24	2292	c.2049C>T	c.(2047-2049)GAC>GAT	p.D683D	PDE2A_uc001oso.2_Silent_p.D662D|PDE2A_uc010rra.1_Silent_p.D676D|PDE2A_uc001osn.2_Silent_p.D427D|PDE2A_uc010rrb.1_Silent_p.D674D|PDE2A_uc010rrd.1_Silent_p.D568D	NM_002599	NP_002590	O00408	PDE2A_HUMAN	phosphodiesterase 2A isoform 1	683	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	AGATCTCGATGTCCCTGGTTG	0.522			NA											17	36					0	0	0.007413	0	0
MAP6	4135	broad.mit.edu	37	11	75298562	75298562	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:75298562C>G	uc001owu.2	-	4	2049	c.1984G>C	c.(1984-1986)GGT>CGT	p.G662R		NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	662	Pro-rich.					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					ACCATGGAACCTTGATTCTTT	0.498	Esophageal Squamous(181;1115 2007 8647 17065 22697)		NA											18	187					0	0	0.00499	0	0
SYTL2	54843	broad.mit.edu	37	11	85445402	85445402	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:85445402G>A	uc010rth.1	-	6	1243	c.967C>T	c.(967-969)CCA>TCA	p.P323S	SYTL2_uc010rtg.1_Missense_Mutation_p.P324S|SYTL2_uc010rti.1_Missense_Mutation_p.P323S|SYTL2_uc010rtj.1_Missense_Mutation_p.P275S|SYTL2_uc001pbf.3_Missense_Mutation_p.P323S|SYTL2_uc010rtf.1_Missense_Mutation_p.P181S	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	323					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		AGGGAGTTTGGGGAAGAGTTG	0.448			NA											50	102					0	0	0.01441	0	0
TYR	7299	broad.mit.edu	37	11	88911910	88911910	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:88911910C>A	uc001pcs.2	+	1	871	c.789C>A	c.(787-789)CTC>CTA	p.L263L		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	263	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	CTAACTTACTCAGCCCAGCAT	0.458			NA							Oculocutaneous_Albinism				21	54					3.83957e-06	4.59934e-06	0.00278	1	0
TYR	7299	broad.mit.edu	37	11	89028412	89028412	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:89028412G>C	uc001pcs.2	+	5	1550	c.1468G>C	c.(1468-1470)GCC>CCC	p.A490P		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	490	Helical; (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	CGTCCTCACTGCCCTGCTGGC	0.537			NA							Oculocutaneous_Albinism				25	84					0	0	0.009535	0	0
FOLH1B	219595	broad.mit.edu	37	11	89421795	89421795	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:89421795C>A	uc001pda.2	+	10	1178	c.652C>A	c.(652-654)CAA>AAA	p.Q218K		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	218					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GGTGTTCTTCCAACGACTTGG	0.313			NA											62	137					1.21526e-53	2.25122e-53	0.01441	1	0
CHORDC1	26973	broad.mit.edu	37	11	89947237	89947237	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:89947237T>C	uc001pdg.2	-	4	688	c.278A>G	c.(277-279)CAG>CGG	p.Q93R	CHORDC1_uc009yvz.2_Missense_Mutation_p.Q74R	NM_012124	NP_036256	Q9UHD1	CHRD1_HUMAN	cysteine and histidine-rich domain-containing	93	Interaction with HSP90AA1 and HSP90AB1 (By similarity).				chaperone-mediated protein folding|regulation of response to stress|response to stress		Hsp90 protein binding|identical protein binding				0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.00915)				GATGTGTTCCTGAAATTTGGG	0.378			NA											45	143					0	0	0.01441	0	0
GPR83	10888	broad.mit.edu	37	11	94126755	94126755	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:94126755G>C	uc001pet.2	-	3	715	c.543C>G	c.(541-543)ATC>ATG	p.I181M		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	181	Cytoplasmic (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TTGTGATTGAGATCCGGGGTT	0.413			NA											23	73					0	0	0.003954	0	0
MMP13	4322	broad.mit.edu	37	11	102822815	102822815	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:102822815G>C	uc001phl.2	-	5	753	c.725C>G	c.(724-726)CCT>CGT	p.P242R		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	242					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		GGTGTAGATAGGAAACATGAG	0.453			NA											63	174					0	0	0.01441	0	0
ANKK1	255239	broad.mit.edu	37	11	113266829	113266829	+	Silent	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:113266829C>T	uc001pny.2	+	5	817	c.723C>T	c.(721-723)GGC>GGT	p.G241G		NM_178510	NP_848605	Q8NFD2	ANKK1_HUMAN	ankyrin repeat and kinase domain containing 1	241	Protein kinase.						ATP binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|ovary(1)|breast(1)	8		all_cancers(61;1.53e-11)|all_epithelial(67;3e-06)|Melanoma(852;4.04e-05)|all_hematologic(158;0.000315)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0461)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Prostate(24;0.194)		BRCA - Breast invasive adenocarcinoma(274;4.82e-06)|Epithelial(105;5.41e-05)|all cancers(92;0.000442)|OV - Ovarian serous cystadenocarcinoma(223;0.238)		TGGCGGCAGGCATGCGGCCCT	0.597			NA											14	57					0	0	0.001855	0	0
AMICA1	120425	broad.mit.edu	37	11	118081381	118081381	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:118081381C>A	uc001psk.2	-	4	419	c.245G>T	c.(244-246)GGG>GTG	p.G82V	AMICA1_uc001psh.2_Missense_Mutation_p.G43V|AMICA1_uc009yzw.1_RNA|AMICA1_uc001psi.2_Missense_Mutation_p.G72V|AMICA1_uc001psj.2_Missense_Mutation_p.G82V|AMICA1_uc010rxw.1_Missense_Mutation_p.G43V|AMICA1_uc010rxx.1_Missense_Mutation_p.G82V|AMICA1_uc001psl.1_Missense_Mutation_p.G38V	NM_001098526	NP_001091996	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen	82	Ig-like V-type 1.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				ovary(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		CTGGAAGCGCCCAATAGGCAC	0.498			NA											34	93					1.06647e-15	1.68941e-15	0.003755	1	0
OR6T1	219874	broad.mit.edu	37	11	123814283	123814283	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:123814283C>A	uc010sab.1	-	1	263	c.263G>T	c.(262-264)GGG>GTG	p.G88V		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	88	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GGTGTGATCCCCCGTGAGGAT	0.498			NA											30	79					3.99451e-17	6.43296e-17	0.009535	1	0
ZBTB44	29068	broad.mit.edu	37	11	130131495	130131495	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:130131495C>T	uc001qga.2	-	2	668	c.274G>A	c.(274-276)GCC>ACC	p.A92T	ZBTB44_uc001qgb.3_Missense_Mutation_p.A92T|ZBTB44_uc001qfx.2_RNA|ZBTB44_uc001qgc.1_Missense_Mutation_p.A92T|ZBTB44_uc001qfz.2_Missense_Mutation_p.A92T	NM_014155	NP_054874	Q8NCP5	ZBT44_HUMAN	zinc finger and BTB domain containing 44	92	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0192)|Lung(977;0.235)		GATAGAGTGGCTGTGTAAGCA	0.408			NA											19	50					0	0	0.006122	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130343194	130343194	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:130343194G>T	uc010scd.1	+	8	2331	c.2331G>T	c.(2329-2331)GAG>GAT	p.E777D		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	777	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		CCATCCTGGAGCCGCTGACCG	0.677			NA											31	75					7.26314e-15	1.12687e-14	0.007291	1	0
NCAPD3	23310	broad.mit.edu	37	11	134086941	134086941	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr11:134086941C>A	uc001qhd.1	-	3	877	c.271G>T	c.(271-273)GCA>TCA	p.A91S	NCAPD3_uc010scm.1_RNA|NCAPD3_uc009zda.1_RNA	NM_015261	NP_056076	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	91					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		TAGAACAATGCCACCAGTGTA	0.403			NA											13	39					4.36969e-10	5.97309e-10	0.001855	1	0
RAD52	5893	broad.mit.edu	37	12	1025913	1025913	+	Missense_Mutation	SNP	T	T	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:1025913T>G	uc001qis.1	-	8	731	c.617A>C	c.(616-618)AAC>ACC	p.N206T	RAD52_uc001qit.1_RNA|RAD52_uc010sdt.1_Missense_Mutation_p.N129T|RAD52_uc001qiu.1_Missense_Mutation_p.N206T|RAD52_uc001qiv.1_RNA|RAD52_uc001qiw.1_RNA|RAD52_uc010sdu.1_Missense_Mutation_p.N206T	NM_134424	NP_602296	P43351	RAD52_HUMAN	RAD52 homolog	206					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)			TCGGCAGCTGTTGTATCTTGC	0.527			NA						Homologous_recombination					33	75					0	0	0.012213	0	0
FGF23	8074	broad.mit.edu	37	12	4479814	4479814	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:4479814G>T	uc001qmq.1	-	3	597	c.451C>A	c.(451-453)CCA>ACA	p.P151T		NM_020638	NP_065689	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23 precursor	151					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			ovary(2)|breast(1)|skin(1)	4			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			TACGGGGGTGGGTTCATGCCT	0.617			NA											38	92					3.33393e-15	5.24456e-15	0.004878	1	0
GALNT8	26290	broad.mit.edu	37	12	4829883	4829883	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:4829883G>T	uc001qne.1	+	1	132	c.40G>T	c.(40-42)GGG>TGG	p.G14W		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	14	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						CCTCTTCATTGGGCTGACTCT	0.512	Colon(108;631 1558 7270 20097 39846)		NA											23	83					3.5997e-14	5.50925e-14	0.014323	1	0
KCNA6	3742	broad.mit.edu	37	12	4920341	4920341	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:4920341G>T	uc001qng.2	+	1	2000	c.1134G>T	c.(1132-1134)CTG>CTT	p.L378L		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	378	Helical; Name=Segment S5; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						AGCTGGGGCTGCTCATCTTCT	0.597			NA								HNSCC(72;0.22)			8	71					0.000274275	0.000306357	0.004482	1	0
KCNA5	3741	broad.mit.edu	37	12	5154413	5154413	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:5154413C>A	uc001qni.2	+	1	1329	c.1100C>A	c.(1099-1101)CCC>CAC	p.P367H		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	367	Helical; Name=Segment S3; (Potential).					Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						GCCATCTTCCCCTACTTCATC	0.622			NA											25	77					3.7963e-18	6.20216e-18	0.00333	1	0
CD163L1	283316	broad.mit.edu	37	12	7531657	7531657	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:7531657T>C	uc001qsy.2	-	9	2314	c.2288A>G	c.(2287-2289)GAA>GGA	p.E763G	CD163L1_uc010sge.1_Missense_Mutation_p.E773G	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	763	SRCR 7.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						GAGAGAGGCTTCCCCTCCAGT	0.448			NA											34	79					0	0	0.013726	0	0
FAM90A1	55138	broad.mit.edu	37	12	8377324	8377324	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:8377324G>T	uc001qui.2	-	4	664	c.105C>A	c.(103-105)CCC>CCA	p.P35P	FAM90A1_uc001quh.2_Silent_p.P35P	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138	35							nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		CTTCTTCATCGGGCGGGGGAG	0.652			NA											8	10					5.18039e-06	6.17277e-06	0.00308	1	0
CLEC9A	283420	broad.mit.edu	37	12	10218183	10218183	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:10218183G>T	uc001qxa.2	+	9	1291	c.678G>T	c.(676-678)ACG>ACT	p.T226T		NM_207345	NP_997228	Q6UXN8	CLC9A_HUMAN	C-type lectin domain family 9, member A	226	Extracellular (Potential).|C-type lectin.				positive regulation of cytokine secretion|receptor-mediated endocytosis	cell surface|integral to membrane	receptor activity|sugar binding			ovary(1)	1						ACTGCAGCACGTGGAAGTATT	0.423			NA											52	93					1.46357e-32	2.64614e-32	0.01441	1	0
OLR1	4973	broad.mit.edu	37	12	10312555	10312555	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:10312555C>G	uc001qxo.1	-	6	860	c.746G>C	c.(745-747)GGA>GCA	p.G249A	OLR1_uc010sgz.1_3'UTR|OLR1_uc010sha.1_3'UTR	NM_002543	NP_002534	P78380	OLR1_HUMAN	oxidized low density lipoprotein (lectin-like)	249	Extracellular (Potential).|C-type lectin.				blood circulation|blood coagulation|inflammatory response|leukocyte migration|proteolysis	extracellular region|integral to plasma membrane|membrane fraction	sugar binding			ovary(1)	1						ATAAACAGCTCCTCGTTGTAT	0.428			NA											37	128					0	0	0.004289	0	0
KLRK1	22914	broad.mit.edu	37	12	10531201	10531201	+	Nonsense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:10531201A>T	uc009zhj.2	-	6	545	c.381T>A	c.(379-381)TGT>TGA	p.C127*	uc001qya.1_Intron|KLRK1_uc001qyb.2_RNA|KLRK1_uc001qyc.2_Nonsense_Mutation_p.C127*|KLRK1_uc009zhk.2_Nonsense_Mutation_p.C127*|KLRK1_uc001qyd.2_Nonsense_Mutation_p.C127*	NM_007360	NP_031386	P26718	NKG2D_HUMAN	NKG2-D type II integral membrane protein	127	Extracellular (Potential).|C-type lectin.				natural killer cell activation|T cell costimulation	integral to plasma membrane	sugar binding				0						TTTGAGACATACAAGAAGCCT	0.368			NA											26	63					0	0	0.005443	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716296	13716296	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:13716296C>A	uc001rbt.2	-	13	4055	c.3876G>T	c.(3874-3876)AAG>AAT	p.K1292N		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1292	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCCGGTTCTTCTTCTGGGCCT	0.622			NA											41	83					1.15183e-24	2.00756e-24	0.009718	1	0
CAPZA3	93661	broad.mit.edu	37	12	18891415	18891415	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:18891415C>A	uc001rdy.2	+	1	371	c.213C>A	c.(211-213)CTC>CTA	p.L71L	PLCZ1_uc001rdv.3_5'Flank|PLCZ1_uc001rdw.3_5'Flank|PLCZ1_uc010sid.1_5'Flank	NM_033328	NP_201585	Q96KX2	CAZA3_HUMAN	capping protein alpha 3	71					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			ovary(1)|central_nervous_system(1)	2	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				ATCCAGTACTCTTGTCTCACC	0.428			NA											49	92					4.18559e-23	7.18438e-23	0.01441	1	0
SLCO1C1	53919	broad.mit.edu	37	12	20890206	20890206	+	Silent	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:20890206T>C	uc001rej.3	+	12	1903	c.1548T>C	c.(1546-1548)ATT>ATC	p.I516I	SLCO1C1_uc010sii.1_Silent_p.I516I|SLCO1C1_uc010sij.1_Silent_p.I467I|SLCO1C1_uc009zip.2_Silent_p.I350I|SLCO1C1_uc001rei.2_Silent_p.I516I|SLCO1C1_uc010sik.1_Silent_p.I398I	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	516	Extracellular (Potential).|Kazal-like.				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					GAAAAAATATTGTAAGAAATC	0.423			NA											20	52					0	0	0.007413	0	0
GYS2	2998	broad.mit.edu	37	12	21721852	21721852	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:21721852G>T	uc001rfb.2	-	5	1025	c.770C>A	c.(769-771)ACG>AAG	p.T257K		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	257					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						TTCAGAAACCGTGGTGAACAC	0.438	Colon(149;9 1820 3690 10544 50424)		NA											26	85					1.64293e-13	2.47535e-13	0.00333	1	0
Unknown	0	broad.mit.edu	37	12	31284361	31284361	+	Silent	SNP	A	A	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:31284361A>G	uc010sjy.1	-	22	2916	c.2916T>C	c.(2914-2916)TAT>TAC	p.Y972Y						RecName: Full=Ovostatin homolog 1; Flags: Precursor;												NA						AGTCCAGAACATAAGTATCAG	0.413			NA											4	40					0	0	0.009096	0	0
ZNF641	121274	broad.mit.edu	37	12	48737288	48737288	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:48737288C>A	uc001rrn.1	-	6	950	c.785G>T	c.(784-786)AGA>ATA	p.R262I	ZNF641_uc001rro.1_Missense_Mutation_p.R248I|ZNF641_uc010sls.1_Missense_Mutation_p.R239I	NM_152320	NP_689533	Q96N77	ZN641_HUMAN	zinc finger protein 641	262	Transactivation.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						TGTGTGGGGTCTTAACAGGGA	0.542			NA											31	44					1.56442e-22	2.65169e-22	0.012213	1	0
TROAP	10024	broad.mit.edu	37	12	49724266	49724266	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:49724266G>T	uc001rtx.3	+	13	1805	c.1638G>T	c.(1636-1638)GAG>GAT	p.E546D	TROAP_uc009zlh.2_Missense_Mutation_p.E546D|TROAP_uc001rty.2_Missense_Mutation_p.E254D	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	546	Cys-rich.|4 X 33 AA approximate tandem repeats.|1.				cell adhesion	cytoplasm				ovary(1)	1						AAGTACCAGAGCCCTACCCTC	0.622			NA											25	60					2.41591e-17	3.91627e-17	0.004656	1	0
KRT85	3891	broad.mit.edu	37	12	52758891	52758891	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:52758891G>T	uc001sag.2	-	2	604	c.484C>A	c.(484-486)CGC>AGC	p.R162S		NM_002283	NP_002274	P78386	KRT85_HUMAN	keratin 85	162	Rod.|Linker 1.				epidermis development	keratin filament	protein binding|structural molecule activity			ovary(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TCGCAGCAGCGCTGGTTCTGG	0.622			NA											35	76					3.86903e-22	6.50918e-22	0.013726	1	0
HOXC12	3228	broad.mit.edu	37	12	54348814	54348814	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:54348814C>T	uc010soq.1	+	1	101	c.101C>T	c.(100-102)GCG>GTG	p.A34V		NM_173860	NP_776272	P31275	HXC12_HUMAN	homeobox C12	34					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1						GCGTCCGGGGCGCAGCTTCCC	0.657			NA											11	24					0	0	0.010729	0	0
HOXC10	3226	broad.mit.edu	37	12	54379592	54379592	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:54379592C>A	uc001sen.2	+	1	647	c.549C>A	c.(547-549)CGC>CGA	p.R183R		NM_017409	NP_059105	Q9NYD6	HXC10_HUMAN	homeobox C10	183					positive regulation of cell proliferation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1						TCAACCCGCGCGCCGAACATC	0.642			NA											11	31					4.3838e-07	5.50411e-07	0.001855	1	0
OR6C1	390321	broad.mit.edu	37	12	55715043	55715043	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:55715043C>A	uc010spi.1	+	1	660	c.660C>A	c.(658-660)ATC>ATA	p.I220I		NM_001005182	NP_001005182	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C,	220	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2						TATACATTATCAGAACAATTT	0.388			NA											27	36					2.79863e-10	3.85665e-10	0.004656	1	0
ESYT1	23344	broad.mit.edu	37	12	56531347	56531347	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:56531347G>A	uc001sjq.2	+	18	2053	c.2003G>A	c.(2002-2004)GGA>GAA	p.G668E	ESYT1_uc001sjr.2_Missense_Mutation_p.G678E	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	668	C2 3.					integral to membrane				ovary(4)|skin(1)	5						TTCTTGGGGGGACTGGTGAAG	0.547			NA											24	194					0	0	0.00333	0	0
TBK1	29110	broad.mit.edu	37	12	64875778	64875778	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:64875778G>C	uc001ssc.1	+	8	1031	c.969G>C	c.(967-969)AAG>AAC	p.K323N		NM_013254	NP_037386	Q9UHD2	TBK1_HUMAN	TANK-binding kinase 1	323	Ubiquitin-like.				I-kappaB kinase/NF-kappaB cascade|innate immune response|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|large_intestine(1)|breast(1)	5				GBM - Glioblastoma multiforme(28;0.0386)		CAGCTCATAAGATTTATATTC	0.294			NA											3	42					0	0	0.004672	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72026208	72026208	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:72026208C>A	uc001swo.2	-	15	3263	c.2904G>T	c.(2902-2904)CGG>CGT	p.R968R		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	968	Potential.				RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						GCTTTTGTAACCGTCTTTTCT	0.378			NA											55	43					3.50607e-19	5.78373e-19	0.01441	1	0
NAV3	89795	broad.mit.edu	37	12	78591054	78591054	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:78591054G>T	uc001syp.2	+	35	6492	c.6319G>T	c.(6319-6321)GCT>TCT	p.A2107S	NAV3_uc001syo.2_Missense_Mutation_p.A2085S|NAV3_uc010sub.1_Missense_Mutation_p.A1564S|NAV3_uc009zsf.2_Missense_Mutation_p.A916S	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	2107						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AGCTAACCTGGCTGAACAGTG	0.348			NA								HNSCC(70;0.22)			21	24					4.4004e-07	5.51474e-07	0.00333	1	0
Unknown	0	broad.mit.edu	37	12	80762012	80762012	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:80762012G>A	uc009zsg.1	+	9	752	c.151G>A	c.(151-153)GAT>AAT	p.D51N	uc001szd.2_Missense_Mutation_p.D190N					RecName: Full=Uncharacterized protein C12orf64;												NA						ATCCCCAAGTGATTATGGTTG	0.358			NA											4	6					0	0	0.009096	0	0
C12orf48	55010	broad.mit.edu	37	12	102589845	102589845	+	Nonsense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:102589845A>T	uc001tjf.2	+	11	1628	c.1516A>T	c.(1516-1518)AAA>TAA	p.K506*	C12orf48_uc001tjg.2_Nonsense_Mutation_p.K425*|C12orf48_uc010swa.1_Nonsense_Mutation_p.K583*|C12orf48_uc001tjh.2_Nonsense_Mutation_p.K425*|C12orf48_uc010swb.1_3'UTR|C12orf48_uc009zuc.2_Nonsense_Mutation_p.K60*|C12orf48_uc001tjj.2_Nonsense_Mutation_p.K221*|C12orf48_uc001tjk.2_3'UTR|C12orf48_uc009zud.2_3'UTR	NM_017915	NP_060385	Q9NWS1	PR1BP_HUMAN	hypothetical protein LOC55010	506					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding				0						GACAGGAAATAAAAGCTCAAA	0.328			NA											29	12					0	0	0.007291	0	0
SSH1	54434	broad.mit.edu	37	12	109186491	109186491	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:109186491C>A	uc001tnm.2	-	14	1551	c.1464G>T	c.(1462-1464)CCG>CCT	p.P488P	SSH1_uc001tnl.2_Silent_p.P176P|SSH1_uc010sxg.1_Silent_p.P499P|SSH1_uc001tnn.3_Silent_p.P488P	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	488					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						GCTGGCTTTCCGGGGTGCCAT	0.652			NA											26	23					2.79863e-10	3.85665e-10	0.004656	1	0
DNAH10	196385	broad.mit.edu	37	12	124393958	124393958	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:124393958G>T	uc001uft.3	+	57	9637	c.9612G>T	c.(9610-9612)TCG>TCT	p.S3204S		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3204	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ATTTTGATTCGATTACCCAGA	0.512			NA											4	14					0.00024832	0.000278283	0.009096	1	0
DNAH10	196385	broad.mit.edu	37	12	124409644	124409644	+	Silent	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:124409644C>T	uc001uft.3	+	67	11485	c.11460C>T	c.(11458-11460)TAC>TAT	p.Y3820Y	DNAH10_uc001ufu.3_Translation_Start_Site	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3820	TPR 4.				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CCTTGGGTTACGATAACAACA	0.473			NA											4	74					0	0	0.000602	0	0
UBC	7316	broad.mit.edu	37	12	125397907	125397907	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:125397907G>C	uc001ugs.3	-	2	859	c.411C>G	c.(409-411)ATC>ATG	p.I137M	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Missense_Mutation_p.I137M|UBC_uc001ugt.2_Missense_Mutation_p.I137M|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_Translation_Start_Site	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	137	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		ACTCTTTCTGGATGTTGTAGT	0.552			NA											29	175					0	0	0.010771	0	0
P2RX2	22953	broad.mit.edu	37	12	133196643	133196643	+	Missense_Mutation	SNP	T	T	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:133196643T>G	uc001ukj.1	+	5	515	c.515T>G	c.(514-516)GTG>GGG	p.V172G	P2RX2_uc001uki.1_Missense_Mutation_p.V172G|P2RX2_uc001ukk.1_Missense_Mutation_p.V172G|P2RX2_uc001ukl.1_Missense_Mutation_p.V148G|P2RX2_uc001ukm.1_Missense_Mutation_p.V100G|P2RX2_uc001ukn.1_Missense_Mutation_p.V80G|P2RX2_uc009zyt.1_Missense_Mutation_p.V172G|P2RX2_uc001uko.1_Silent_p.G136G	NM_170682	NP_733782	Q9UBL9	P2RX2_HUMAN	purinergic receptor P2X2 isoform A	172	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|protein homooligomerization	integral to membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0767)		OV - Ovarian serous cystadenocarcinoma(86;2.32e-08)|Epithelial(86;8.62e-08)|all cancers(50;4.5e-06)		ACCTGCGAGGTGTTCGGCTGG	0.677			NA											4	4					0	0	0.009096	0	0
TUBA3C	7278	broad.mit.edu	37	13	19751104	19751104	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr13:19751104G>T	uc009zzj.2	-	4	1068	c.1019C>A	c.(1018-1020)ACC>AAC	p.T340N		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	340					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		AAACTGGATGGTGCGCTTGGT	0.527			NA											13	64					7.93312e-07	9.79719e-07	0.00245	1	0
RNF17	56163	broad.mit.edu	37	13	25352513	25352513	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr13:25352513A>T	uc001upr.2	+	4	439	c.398A>T	c.(397-399)AAG>ATG	p.K133M	RNF17_uc010tdd.1_Translation_Start_Site|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.K133M|RNF17_uc001ups.2_Missense_Mutation_p.K72M|RNF17_uc001upq.1_Missense_Mutation_p.K133M	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	133					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TCCACAGACAAGACTCTTTTG	0.378			NA											19	58					0	0	0.007413	0	0
FLT3	2322	broad.mit.edu	37	13	28599082	28599082	+	Splice_Site	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr13:28599082T>C	uc001urw.2	-	18	2290	c.2208_splice	c.e18-1	p.S736_splice	FLT3_uc010aao.2_Splice_Site|FLT3_uc010tdn.1_Splice_Site_p.S736_splice	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor						positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	CCAGGCATGCTATTAAAAAAT	0.299			NA	Mis|O		AML|ALL								3	96					0	0	0.004672	0	0
MTUS2	23281	broad.mit.edu	37	13	29599271	29599271	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr13:29599271G>T	uc001usl.3	+	1	524	c.466G>T	c.(466-468)GTT>TTT	p.V156F		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	146						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						CAGTCTAGACGTTTTGGCTAA	0.507			NA											11	86					2.68362e-12	3.87126e-12	0.013537	1	0
STARD13	90627	broad.mit.edu	37	13	33686964	33686964	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr13:33686964C>T	uc001uuw.2	-	9	2512	c.2386G>A	c.(2386-2388)GTC>ATC	p.V796I	STARD13_uc001uuu.2_Missense_Mutation_p.V788I|STARD13_uc001uuv.2_Missense_Mutation_p.V678I|STARD13_uc001uux.2_Missense_Mutation_p.V761I|STARD13_uc010tec.1_RNA	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	796	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		AAGTTGACGACGTCGTTCAGG	0.542			NA											58	74					0	0	0.01441	0	0
FREM2	341640	broad.mit.edu	37	13	39262601	39262601	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr13:39262601G>C	uc001uwv.2	+	1	1429	c.1120G>C	c.(1120-1122)GAT>CAT	p.D374H		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	374	CSPG 1.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GGTGAGCACCGATGATCGCAG	0.577			NA											29	81					0	0	0.009535	0	0
HTR2A	3356	broad.mit.edu	37	13	47409356	47409356	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr13:47409356G>T	uc001vbq.2	-	3	1166	c.1032C>A	c.(1030-1032)ATC>ATA	p.I344I	HTR2A_uc001vbr.2_Silent_p.I244I|HTR2A_uc010acr.2_Silent_p.I344I	NM_000621	NP_000612	P28223	5HT2A_HUMAN	5-hydroxytryptamine receptor 2A isoform 1	344	Helical; Name=6; (By similarity).				ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	TGACGGCCATGATGTTTGTGA	0.493			NA											6	80					0.00116845	0.00128189	0.001168	1	0
FARP1	10160	broad.mit.edu	37	13	99042284	99042284	+	Missense_Mutation	SNP	T	T	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr13:99042284T>G	uc001vnj.2	+	10	1265	c.929T>G	c.(928-930)GTT>GGT	p.V310G	FARP1_uc001vnh.2_Missense_Mutation_p.V310G	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	310	FERM.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			AAAATCTGTGTTGAACATCAT	0.483			NA											30	125					0	0	0.008361	0	0
ABHD13	84945	broad.mit.edu	37	13	108881888	108881888	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr13:108881888G>T	uc001vqq.2	+	2	587	c.322G>T	c.(322-324)GGA>TGA	p.G108*		NM_032859	NP_116248	Q7L211	ABHDD_HUMAN	abhydrolase domain containing 13	108						integral to membrane	hydrolase activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					ACGATACACTGGAGACAATTC	0.388	Pancreas(22;506 789 38166 45896 51596)		NA											10	41					1.76689e-08	2.32612e-08	0.006214	1	0
MYO16	23026	broad.mit.edu	37	13	109459025	109459025	+	Splice_Site	SNP	A	A	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr13:109459025A>G	uc001vqt.1	+	7	802	c.676_splice	c.e7-2	p.L226_splice	MYO16_uc010agk.1_Splice_Site_p.L248_splice|MYO16_uc001vqu.1_Splice_Site_p.L26_splice	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8						cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TCTTCGCTGCAGTTACACATG	0.423			NA											14	38					0	0	0.001855	0	0
OR4L1	122742	broad.mit.edu	37	14	20528375	20528375	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr14:20528375C>A	uc001vwn.1	+	1	172	c.172C>A	c.(172-174)CCC>ACC	p.P58T		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	58	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		CCTTCATTCTCCCTTGTACTT	0.423			NA											65	139					1.1794e-34	2.13806e-34	0.01441	1	0
OXA1L	5018	broad.mit.edu	37	14	23237370	23237370	+	Silent	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr14:23237370C>T	uc001wgn.2	+	3	609	c.609C>T	c.(607-609)GCC>GCT	p.A203A	OXA1L_uc010tnc.1_Silent_p.A203A|OXA1L_uc001wgo.2_RNA|OXA1L_uc010akc.2_Silent_p.A203A|OXA1L_uc001wgp.2_Silent_p.A127A|OXA1L_uc001wgq.2_5'UTR	NM_005015	NP_005006	Q15070	OXA1L_HUMAN	oxidase (cytochrome c) assembly 1-like	143	Helical; (Potential).				aerobic respiration|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial respiratory chain complex I assembly|negative regulation of ATPase activity|negative regulation of oxidoreductase activity|protein insertion into membrane|protein tetramerization	integral to mitochondrial membrane|mitochondrial respiratory chain|protein complex	protein homodimerization activity|ribosome binding			central_nervous_system(1)	1	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.0096)		GGTGGGGGGCCATTGCTGCAT	0.488			NA											20	41					0	0	0.008871	0	0
MYH6	4624	broad.mit.edu	37	14	23855735	23855735	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr14:23855735T>A	uc001wjv.2	-	33	4815	c.4748A>T	c.(4747-4749)GAG>GTG	p.E1583V		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	1583	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TTCCATCTCCTCGTCCTTCTC	0.632			NA											74	203					0	0	0.01441	0	0
AKAP6	9472	broad.mit.edu	37	14	33291371	33291371	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr14:33291371C>T	uc001wrq.2	+	13	4522	c.4352C>T	c.(4351-4353)CCT>CTT	p.P1451L		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1451					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AAACATACCCCTGACTGTTTG	0.363	Melanoma(49;821 1200 7288 13647 42351)		NA											10	44					0	0	0.008291	0	0
SSTR1	6751	broad.mit.edu	37	14	38679167	38679167	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr14:38679167C>A	uc001wul.1	+	3	1190	c.573C>A	c.(571-573)CCC>CCA	p.P191P	SSTR1_uc010amu.1_Intron	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	191	Helical; Name=4; (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	TCATCCTGCCCATCGTGGTCT	0.657			NA											11	40					7.03913e-09	9.48813e-09	0.013537	1	0
FANCM	57697	broad.mit.edu	37	14	45645710	45645710	+	Silent	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr14:45645710T>C	uc001wwd.3	+	14	3852	c.3753T>C	c.(3751-3753)GAT>GAC	p.D1251D	FANCM_uc010anf.2_Silent_p.D1225D|FANCM_uc001wwe.3_Silent_p.D787D|FANCM_uc010ang.2_Silent_p.D465D	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1251					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						ATACATCAGATAGCAATAGAC	0.328			NA						Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				24	52					0	0	0.00278	0	0
C14orf118	55668	broad.mit.edu	37	14	76633041	76633041	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr14:76633041G>T	uc001xsh.2	+	3	784	c.698G>T	c.(697-699)GGG>GTG	p.G233V	C14orf118_uc001xsi.2_Missense_Mutation_p.G233V|C14orf118_uc001xsj.1_Missense_Mutation_p.G233V|C14orf118_uc001xsk.1_Missense_Mutation_p.G233V|C14orf118_uc001xsl.2_RNA	NM_017926	NP_060396	Q9NWQ4	CN118_HUMAN	hypothetical protein LOC55668 isoform 1	233										ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.0172)		AGTGACACTGGGCTCTTTACC	0.428			NA											6	43					0.00116845	0.00128189	0.001168	1	0
GALC	2581	broad.mit.edu	37	14	88431915	88431915	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr14:88431915C>G	uc001xvt.2	-	9	1366	c.967G>C	c.(967-969)GGG>CGG	p.G323R	GALC_uc010tvw.1_RNA|GALC_uc010tvx.1_Missense_Mutation_p.G297R|GALC_uc010tvy.1_Missense_Mutation_p.G300R|GALC_uc010tvz.1_Missense_Mutation_p.G267R|GALC_uc001xvu.1_Missense_Mutation_p.G323R	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	323			G -> R (in GLD).		carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0						GTCATCAACCCGCATCTCCCA	0.448			NA											20	54					0	0	0.008871	0	0
AHNAK2	113146	broad.mit.edu	37	14	105413167	105413167	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr14:105413167G>T	uc010axc.1	-	7	8741	c.8621C>A	c.(8620-8622)GCT>GAT	p.A2874D	AHNAK2_uc001ypx.2_Missense_Mutation_p.A2774D	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2874						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CACCTGGCCAGCCTGGACCTC	0.627			NA											63	303					4.17052e-40	7.64219e-40	0.01441	1	0
AHNAK2	113146	broad.mit.edu	37	14	105420366	105420366	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr14:105420366G>T	uc010axc.1	-	7	1542	c.1422C>A	c.(1420-1422)GGC>GGA	p.G474G	AHNAK2_uc001ypx.2_Silent_p.G374G	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	474						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CAATCTGTGTGCCTCCTTCGG	0.522			NA											27	55					2.61193e-14	4.00654e-14	0.009535	1	0
AHNAK2	113146	broad.mit.edu	37	14	105420648	105420648	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr14:105420648C>A	uc010axc.1	-	7	1260	c.1140G>T	c.(1138-1140)AGG>AGT	p.R380S	AHNAK2_uc001ypx.2_Missense_Mutation_p.R280S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	380						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCTGTTCTGCCCTCTCCTCTC	0.632			NA											30	86					1.06801e-11	1.50857e-11	0.009535	1	0
TMEM121	80757	broad.mit.edu	37	14	105995420	105995420	+	Silent	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr14:105995420C>T	uc001yrp.1	+	2	400	c.249C>T	c.(247-249)ATC>ATT	p.I83I	ADAM6_uc010tyt.1_Intron|uc001yrr.2_5'Flank	NM_025268	NP_079544	Q9BTD3	TM121_HUMAN	hole protein	83	Helical; (Potential).					integral to membrane					0		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0188)	Epithelial(152;0.0959)|all cancers(159;0.235)		TCCTTTACATCTTCGTGCTGG	0.557			NA											4	17					0	0	0.000602	0	0
BCL8	606	broad.mit.edu	37	15	20874950	20874950	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr15:20874950T>C	uc010tze.1	-	3	395	c.188A>G	c.(187-189)TAT>TGT	p.Y63C	BCL8_uc010tzd.1_RNA	NR_027992				RecName: Full=Putative protein BCL8;												0						CAAATATGTATATAGGGAAAG	0.279			NA											10	45					0	0	0.006214	0	0
C15orf2	23742	broad.mit.edu	37	15	24921596	24921596	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr15:24921596C>A	uc001ywo.2	+	1	1056	c.582C>A	c.(580-582)ACC>ACA	p.T194T		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	194					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CCCAGGGCACCCAGGGAGACG	0.582			NA											8	16					0.00307968	0.00334084	0.00308	1	0
RYR3	6263	broad.mit.edu	37	15	33822838	33822838	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr15:33822838G>C	uc001zhi.2	+	4	395	c.325G>C	c.(325-327)GTT>CTT	p.V109L	RYR3_uc010bar.2_Missense_Mutation_p.V109L	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	109	Cytoplasmic (By similarity).|MIR 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CGGCCATGCAGTTCTCCTGAG	0.527			NA											7	18					0	0	0.004482	0	0
C15orf23	90417	broad.mit.edu	37	15	40675518	40675518	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr15:40675518C>T	uc001zll.2	+	2	414	c.299C>T	c.(298-300)CCG>CTG	p.P100L	C15orf23_uc010ucp.1_Missense_Mutation_p.P100L|C15orf23_uc001zlo.2_Missense_Mutation_p.P100L|C15orf23_uc001zlm.2_RNA|C15orf23_uc001zln.2_RNA	NM_033286	NP_150628	Q9Y448	T4AF1_HUMAN	TRAF4 associated factor 1 isoform a	100						nucleus	protein binding			ovary(1)|skin(1)	2		all_cancers(109;2.34e-14)|all_epithelial(112;9.21e-12)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.39e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0798)		GGCGGCCAGCCGGCAGGTGAG	0.682			NA											7	10					0	0	0.00308	0	0
TYRO3	7301	broad.mit.edu	37	15	41864678	41864678	+	Silent	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr15:41864678C>T	uc001zof.1	+	15	2015	c.1791C>T	c.(1789-1791)CCC>CCT	p.P597P		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	597	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GCCGTCTCCCCATCCCCATGG	0.597			NA											8	62					0	0	0.00308	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42379517	42379517	+	Missense_Mutation	SNP	A	A	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr15:42379517A>C	uc001zox.2	-	3	331	c.236T>G	c.(235-237)CTT>CGT	p.L79R		NM_178034	NP_828848	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD	79	C2.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			large_intestine(1)|skin(1)	2		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		ACTTTGGATAAGGAAACGGAA	0.562			NA											3	114					0	0	0.004672	0	0
PRTG	283659	broad.mit.edu	37	15	55916678	55916678	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr15:55916678C>G	uc002adg.2	-	18	3003	c.2955G>C	c.(2953-2955)CAG>CAC	p.Q985H		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	985					multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		GAGTTCCATTCTGTGCCGTCT	0.433			NA											7	33					0	0	0.00308	0	0
PRTG	283659	broad.mit.edu	37	15	55964743	55964743	+	Silent	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr15:55964743A>T	uc002adg.2	-	11	1989	c.1941T>A	c.(1939-1941)GCT>GCA	p.A647A	PRTG_uc002adh.2_Silent_p.A149A	NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	647	Fibronectin type-III 3.				multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		AGCCCTGAATAGCAGCTGTGT	0.488			NA											31	38					0	0	0.008361	0	0
Unknown	0	broad.mit.edu	37	15	76074505	76074505	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr15:76074505G>T	uc010umm.1	+	8	684	c.607G>T	c.(607-609)GTG>TTG	p.V203L	uc002bba.1_5'Flank					SubName: Full=cDNA FLJ59077, highly similar to Golgin subfamily A member 6;												NA						GAACGCACACGTGACACAGGT	0.577			NA											9	18					1.12685e-05	1.32181e-05	0.004482	1	0
ZNF774	342132	broad.mit.edu	37	15	90903397	90903397	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr15:90903397G>T	uc002bpk.3	+	4	520	c.334G>T	c.(334-336)GAG>TAG	p.E112*		NM_001004309	NP_001004309	Q6NX45	ZN774_HUMAN	zinc finger protein 774	112					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(11;0.00551)|Lung NSC(78;0.0158)|all_lung(78;0.0331)		BRCA - Breast invasive adenocarcinoma(143;0.0224)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			AGGAAACTGGGAGCAAGGCCT	0.473			NA											16	25					2.23348e-06	2.70895e-06	0.004007	1	0
C16orf11	146325	broad.mit.edu	37	16	613968	613968	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr16:613968C>A	uc002chk.2	+	2	953	c.674C>A	c.(673-675)CCC>CAC	p.P225H		NM_145270	NP_660313	P0CG20	CP011_HUMAN	hypothetical protein LOC146325	225	Pro-rich.									central_nervous_system(1)	1						TACTTGGGGCCCTCACTGGCC	0.731			NA											3	3					0.004672	0.00501999	0.004672	1	0
A2BP1	54715	broad.mit.edu	37	16	7760649	7760649	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr16:7760649G>A	uc002cys.2	+	16	2084	c.1096G>A	c.(1096-1098)GCC>ACC	p.A366T	A2BP1_uc002cyt.2_Missense_Mutation_p.A339T|A2BP1_uc010uyb.1_Missense_Mutation_p.A366T|A2BP1_uc002cyw.2_3'UTR|A2BP1_uc002cyy.2_Missense_Mutation_p.A387T|A2BP1_uc002cyx.2_Intron|A2BP1_uc010uyc.1_Missense_Mutation_p.A360T	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	366					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		TTTGACTGATGCCAAGACTAG	0.408			NA											44	61					0	0	0.011902	0	0
OTOA	146183	broad.mit.edu	37	16	21739679	21739679	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr16:21739679G>T	uc002djh.2	+	19	2135	c.2134G>T	c.(2134-2136)GGC>TGC	p.G712C	uc002diq.3_Intron|OTOA_uc010vbj.1_Missense_Mutation_p.G633C|OTOA_uc002dji.2_Missense_Mutation_p.G388C|OTOA_uc010vbk.1_Missense_Mutation_p.G360C	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	726					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		TGCTCTACACGGCCTCAGAGA	0.597			NA											13	17					2.31682e-05	2.68056e-05	0.003163	1	0
SALL1	6299	broad.mit.edu	37	16	51176050	51176050	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr16:51176050G>T	uc010vgs.1	-	2	114	c.83C>A	c.(82-84)ACA>AAA	p.T28K	SALL1_uc010vgr.1_5'UTR|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	28					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ACCCTTTTCTGTGTCTCCTAC	0.463	GBM(103;1352 1446 1855 4775 8890)		NA											40	94					6.45866e-13	9.5195e-13	0.00874	1	0
RPGRIP1L	23322	broad.mit.edu	37	16	53672256	53672256	+	Missense_Mutation	SNP	T	T	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr16:53672256T>G	uc002ehp.2	-	20	3090	c.3026A>C	c.(3025-3027)GAA>GCA	p.E1009A	RPGRIP1L_uc002eho.3_Intron|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.E1009A|RPGRIP1L_uc010cbx.2_Intron|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.E1009A	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	1009					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				CATATTAATTTCTATTTCTGG	0.338			NA											7	51					0	0	0.001984	0	0
GNAO1	2775	broad.mit.edu	37	16	56377844	56377844	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr16:56377844G>T	uc002eit.3	+	8	1944	c.1047G>T	c.(1045-1047)CGG>CGT	p.R349R	GNAO1_uc002eiu.3_Intron	NM_138736	NP_620073	P09471	GNAO_HUMAN	guanine nucleotide binding protein, alpha	349					dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			lung(1)|breast(1)	2		all_neural(199;0.159)				AAAACCTGCGGGGCTGTGGAC	0.622			NA											18	33					5.26018e-13	7.7869e-13	0.012319	1	0
AMFR	267	broad.mit.edu	37	16	56438863	56438863	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr16:56438863G>A	uc002eiy.2	-	6	1003	c.798C>T	c.(796-798)CTC>CTT	p.L266L	AMFR_uc002eix.2_5'Flank	NM_001144	NP_001135	Q9UKV5	AMFR2_HUMAN	autocrine motility factor receptor	266					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein oligomerization|protein polyubiquitination	integral to endoplasmic reticulum membrane|integral to membrane of membrane fraction	protein binding|protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)	2						ACAGGAGAGTGAGCTCCATGA	0.478	Pancreas(2;144 323 39528)		NA											7	37					0	0	0.001984	0	0
PMFBP1	83449	broad.mit.edu	37	16	72163128	72163128	+	Missense_Mutation	SNP	C	C	A	rs34703574		TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr16:72163128C>A	uc002fcc.3	-	13	1974	c.1802G>T	c.(1801-1803)AGG>ATG	p.R601M	PMFBP1_uc002fcd.2_Missense_Mutation_p.R596M|PMFBP1_uc002fce.2_Intron|PMFBP1_uc002fcf.2_Missense_Mutation_p.R451M|PMFBP1_uc010cgo.1_5'Flank	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	601	Potential.									ovary(2)	2		Ovarian(137;0.179)				GCCTTGCTCCCTGTGCTGAAA	0.433			NA											39	239					1.67305e-13	2.50957e-13	0.00623	1	0
CNTNAP4	85445	broad.mit.edu	37	16	76486440	76486440	+	Silent	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr16:76486440T>A	uc002feu.1	+	10	1492	c.1107T>A	c.(1105-1107)TCT>TCA	p.S369S	CNTNAP4_uc002fev.1_Silent_p.S233S|CNTNAP4_uc010chb.1_Silent_p.S296S|CNTNAP4_uc002fex.1_Silent_p.S372S|CNTNAP4_uc002few.2_Silent_p.S344S	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	369	Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						AACCACAATCTATGCCCGTGA	0.383			NA											19	100					0	0	0.012319	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76513434	76513434	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr16:76513434C>A	uc002feu.1	+	14	2266	c.1881C>A	c.(1879-1881)ACC>ACA	p.T627T	CNTNAP4_uc002fev.1_Silent_p.T491T|CNTNAP4_uc010chb.1_Silent_p.T554T|CNTNAP4_uc002fex.1_Silent_p.T630T|CNTNAP4_uc002few.2_Silent_p.T602T	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	627	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						GCAATATGACCGGTGAGTTAA	0.338			NA											22	105					7.45023e-12	1.05896e-11	0.010504	1	0
PKD1L2	114780	broad.mit.edu	37	16	81181898	81181898	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr16:81181898G>A	uc002fgh.1	-	29	4818	c.4818C>T	c.(4816-4818)CCC>CCT	p.P1606P	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1606	Helical; (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGAGGTTGATGGGGAACATGA	0.552			NA											11	45					0	0	0.008291	0	0
JPH3	57338	broad.mit.edu	37	16	87678336	87678336	+	Silent	SNP	C	C	A	rs112449440		TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr16:87678336C>A	uc002fkd.2	+	2	1109	c.855C>A	c.(853-855)ACC>ACA	p.T285T	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	285	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		CCACCACCACCGAGACCTACG	0.672			NA											15	41					0.000422831	0.000471513	0.004007	1	0
TP53	7157	broad.mit.edu	37	17	7576855	7576855	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:7576855G>A	uc002gim.2	-	9	1185	c.991C>T	c.(991-993)CAG>TAG	p.Q331*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.Q331*|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Nonsense_Mutation_p.Q199*|TP53_uc010cng.1_Nonsense_Mutation_p.Q199*|TP53_uc002gii.1_Nonsense_Mutation_p.Q199*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q331*|TP53_uc010cni.1_Nonsense_Mutation_p.Q331*|TP53_uc002gij.2_Nonsense_Mutation_p.Q331*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	331	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		Q -> R (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q331*(14)|p.0?(7)|p.Q331P(3)|p.Q331fs*6(1)|p.?(1)|p.Q331Q(1)|p.Q331R(1)|p.Q331H(1)|p.Q331fs*14(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTTAGTACCTGAAGGGTGAAA	0.448	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			20	35					0	0	0.012319	0	0
PIK3R6	146850	broad.mit.edu	37	17	8770949	8770949	+	Translation_Start_Site	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:8770949C>A	uc002glq.1	-	1	46	c.-194G>T	c.(-196--192)GAGGC>GATGC		PIK3R6_uc002glr.1_RNA|PIK3R6_uc002gls.1_RNA	NM_001010855	NP_001010855	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6						platelet activation	cytosol					0						TTGGGGGAGCCTCCACGGGTG	0.587			NA											11	19					2.80697e-09	3.79866e-09	0.010729	1	0
MYH13	8735	broad.mit.edu	37	17	10222405	10222405	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:10222405A>G	uc002gmk.1	-	27	3530	c.3440T>C	c.(3439-3441)CTG>CCG	p.L1147P		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1147	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						GATCTCCTCCAGTTCCCTGGC	0.552			NA											54	80					0	0	0.01441	0	0
CYTSB	92521	broad.mit.edu	37	17	20107987	20107987	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:20107987G>T	uc002gwq.2	+	4	770	c.625G>T	c.(625-627)GGC>TGC	p.G209C	CYTSB_uc010cqx.2_Missense_Mutation_p.G209C|CYTSB_uc002gwr.2_Missense_Mutation_p.G209C|CYTSB_uc002gws.2_Missense_Mutation_p.G209C|CYTSB_uc002gwv.2_Missense_Mutation_p.G128C|CYTSB_uc010vzf.1_Intron|CYTSB_uc002gww.2_5'UTR|CYTSB_uc002gwt.2_Missense_Mutation_p.G128C|CYTSB_uc002gwu.2_Missense_Mutation_p.G128C	NM_001033553	NP_001028725	Q5M775	CYTSB_HUMAN	spectrin domain with coiled-coils 1 NSP5b3b	209						nucleus					0						TGATGCTTTGGGCCCAAATGT	0.438			NA											48	94					9.22156e-22	1.54758e-21	0.01441	1	0
KIAA0100	9703	broad.mit.edu	37	17	26965369	26965369	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:26965369G>A	uc002hbu.2	-	13	1512	c.1413C>T	c.(1411-1413)TGC>TGT	p.C471C		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	471						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					CCACACGCCAGCAGAGGTGGT	0.567			NA											14	29					0	0	0.001855	0	0
SEZ6	124925	broad.mit.edu	37	17	27306716	27306716	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:27306716G>A	uc002hdp.2	-	3	1034	c.840C>T	c.(838-840)GGC>GGT	p.G280G	SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Silent_p.G280G|SEZ6_uc002hdq.1_Silent_p.G155G|SEZ6_uc010crz.1_Silent_p.G280G	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	280	Extracellular (Potential).					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			CCACGCCATAGCCAGGGTAGA	0.542			NA											4	21					0	0	0.009096	0	0
ANKRD13B	124930	broad.mit.edu	37	17	27935036	27935036	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:27935036G>T	uc002hei.2	+	3	396	c.283G>T	c.(283-285)GAG>TAG	p.E95*	ANKRD13B_uc002heh.2_Intron|ANKRD13B_uc002hej.2_RNA	NM_152345	NP_689558	Q86YJ7	AN13B_HUMAN	ankyrin repeat domain 13B	95	ANK 2.										0						CCGGGACCTGGAGCTGGTGCA	0.662			NA											18	22					1.02788e-11	1.45492e-11	0.00499	1	0
NF1	4763	broad.mit.edu	37	17	29661882	29661882	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:29661882G>T	uc002hgg.2	+	40	6172	c.5839G>T	c.(5839-5841)GAA>TAA	p.E1947*	NF1_uc002hgh.2_Nonsense_Mutation_p.E1926*|NF1_uc010cso.2_Nonsense_Mutation_p.E135*|NF1_uc010wbt.1_5'Flank|NF1_uc010wbu.1_5'Flank	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1947					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CCTTTGTTTGGAATACATGAC	0.333			NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			8	35					4.68919e-08	6.09056e-08	0.008291	1	0
SLFN12L	342615	broad.mit.edu	37	17	33849347	33849347	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:33849347G>A	uc002hjn.2	-	2	931	c.52C>T	c.(52-54)CAC>TAC	p.H18Y		NM_001145027	NP_001138499			schlafen family member 12-like											ovary(1)	1						AGAATTCTGTGTGCCTCACAG	0.393			NA											7	42					0	0	0.001984	0	0
AP2B1	163	broad.mit.edu	37	17	34044368	34044368	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:34044368G>T	uc002hjr.2	+	20	2928	c.2739G>T	c.(2737-2739)ACG>ACT	p.T913T	AP2B1_uc002hjq.2_Silent_p.T927T|AP2B1_uc010wci.1_Silent_p.T889T|AP2B1_uc002hjs.2_Silent_p.T856T|AP2B1_uc002hjt.2_Silent_p.T927T|AP2B1_uc010ctv.2_Silent_p.T927T|AP2B1_uc010wcj.1_Silent_p.T664T	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	913	Interaction with ARRB1.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		CCAATTACACGGTAAGGCCTT	0.493			NA											14	90					1.5739e-10	2.19568e-10	0.004007	1	0
CCL15	6359	broad.mit.edu	37	17	34328476	34328476	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:34328476G>T	uc010wcu.1	-	1	625	c.56C>A	c.(55-57)TCC>TAC	p.S19Y	CCL14-CCL15_uc010wcs.1_RNA|CCL14-CCL15_uc010wct.1_RNA	NM_032965	NP_116741	Q16663	CCL15_HUMAN	chemokine (C-C motif) ligand 15 precursor	19					cell-cell signaling|cellular calcium ion homeostasis|immune response	extracellular space	chemoattractant activity|chemokine activity|heparin binding|signal transducer activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CTGGGCCTGGGATCCAAGGAC	0.587			NA											4	30					0.00909568	0.00968112	0.009096	1	0
HOXB4	3214	broad.mit.edu	37	17	46654118	46654118	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:46654118G>T	uc002inp.2	-	2	784	c.722C>A	c.(721-723)CCT>CAT	p.P241H	HOXB3_uc010wlm.1_Intron|HOXB3_uc010dbf.2_Intron|HOXB3_uc010dbg.2_Intron|HOXB3_uc002ino.2_5'Flank|HOXB3_uc010wlk.1_5'Flank|HOXB3_uc010wll.1_Intron	NM_024015	NP_076920	P17483	HXB4_HUMAN	homeobox B4	241						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGGCCGGCCAGGGGGCCCTCC	0.682			NA											10	39					7.48243e-07	9.29137e-07	0.006214	1	0
KIF2B	84643	broad.mit.edu	37	17	51900967	51900967	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:51900967C>A	uc002iua.2	+	1	729	c.573C>A	c.(571-573)ATC>ATA	p.I191I	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	191					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						TGCACATGATCGAAGAGTATC	0.582			NA											12	54					2.27111e-07	2.88354e-07	0.013537	1	0
KIF2B	84643	broad.mit.edu	37	17	51901301	51901301	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:51901301G>T	uc002iua.2	+	1	1063	c.907G>T	c.(907-909)GGG>TGG	p.G303W	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	303	ATP (By similarity).|Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CTTTGCCTATGGGCAGACGGG	0.552			NA											23	55					3.83957e-06	4.59934e-06	0.00278	1	0
EFCAB3	146779	broad.mit.edu	37	17	60484501	60484501	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:60484501G>A	uc002izu.1	+	8	873	c.795G>A	c.(793-795)GAG>GAA	p.E265E	EFCAB3_uc010wpc.1_Silent_p.E317E	NM_173503	NP_775774	Q8N7B9	EFCB3_HUMAN	EF-hand calcium binding domain 3 isoform b	265							calcium ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			AGAAATTAGAGATGCTAAGAA	0.368			NA											26	66					0	0	0.003954	0	0
SMARCD2	6603	broad.mit.edu	37	17	61914849	61914849	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:61914849C>T	uc010deb.1	-	2	670	c.353G>A	c.(352-354)CGC>CAC	p.R118H	SMARCD2_uc010wpt.1_Missense_Mutation_p.R70H|SMARCD2_uc010dea.1_Missense_Mutation_p.R43H|SMARCD2_uc010dec.1_Missense_Mutation_p.R97H	NM_001098426	NP_001091896	Q92925	SMRD2_HUMAN	SWI/SNF-related matrix-associated	118	Pro-rich.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	SWI/SNF complex	protein binding|transcription coactivator activity				0						CACAAGCAGGCGTTTTCGGAA	0.632			NA											38	79					0	0	0.011902	0	0
RGS9	8787	broad.mit.edu	37	17	63200369	63200369	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:63200369C>G	uc002jfe.2	+	15	1263	c.1153C>G	c.(1153-1155)CGC>GGC	p.R385G	RGS9_uc010dem.2_Missense_Mutation_p.R382G|RGS9_uc002jfd.2_Missense_Mutation_p.R382G|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Missense_Mutation_p.R156G	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	385	RGS.				intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						GCACCCCCACCGCTATGTGCT	0.587			NA											4	38					0	0	0.000602	0	0
ABCA10	10349	broad.mit.edu	37	17	67212137	67212137	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:67212137G>T	uc010dfa.1	-	9	1556	c.677C>A	c.(676-678)GCA>GAA	p.A226E	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_5'Flank|ABCA10_uc010dfc.1_Missense_Mutation_p.A118E	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	226	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					GAAAGCCAATGCTATCTGAAG	0.368			NA											6	55					0.00116845	0.00128189	0.001168	1	0
GPR142	350383	broad.mit.edu	37	17	72368430	72368430	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:72368430G>T	uc010wqy.1	+	4	1080	c.1080G>T	c.(1078-1080)CTG>CTT	p.L360L	GPR142_uc010wqx.1_Silent_p.L272L	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	360	Helical; Name=6; (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CCATCCTCCTGGGCATCACCA	0.667			NA											20	58					1.15919e-05	1.35739e-05	0.008871	1	0
OTOP2	92736	broad.mit.edu	37	17	72926892	72926892	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:72926892G>C	uc010wrp.1	+	7	1251	c.1162G>C	c.(1162-1164)GTG>CTG	p.V388L		NM_178160	NP_835454	Q7RTS6	OTOP2_HUMAN	otopetrin 2	388	Helical; (Potential).					integral to membrane				ovary(3)|large_intestine(1)	4	all_lung(278;0.172)|Lung NSC(278;0.207)					CTACTCCATCGTGGCTGTGGT	0.617			NA											7	27					0	0	0.001984	0	0
KIAA0195	9772	broad.mit.edu	37	17	73488697	73488697	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:73488697C>T	uc002jnz.3	+	15	2014	c.1739C>T	c.(1738-1740)ACC>ATC	p.T580I	KIAA0195_uc010wsa.1_Missense_Mutation_p.T590I|KIAA0195_uc010wsb.1_Missense_Mutation_p.T220I|KIAA0195_uc002job.3_5'Flank	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	580					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CTGCACCTCACCTCCCTCAAA	0.592			NA											13	62					0	0	0.013537	0	0
CANT1	124583	broad.mit.edu	37	17	76993507	76993507	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:76993507G>A	uc002jwn.2	-	4	637	c.198C>T	c.(196-198)CCC>CCT	p.P66P	CANT1_uc002jwk.2_Silent_p.P66P|CANT1_uc002jwj.2_Silent_p.P66P|CANT1_uc002jwl.2_RNA|CANT1_uc002jwm.1_5'Flank	NM_001159772	NP_001153244	Q8WVQ1	CANT1_HUMAN	calcium activated nucleotidase 1	66	Lumenal (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to membrane	calcium ion binding|nucleoside-diphosphatase activity|signal transducer activity				0			BRCA - Breast invasive adenocarcinoma(99;0.0362)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			GGGGCCTGCCGGGGGCCGGGC	0.682			NA	T	ETV4	prostate								8	33					0	0	0.00308	0	0
LPIN2	9663	broad.mit.edu	37	18	2931392	2931392	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr18:2931392C>A	uc002klo.2	-	9	1557	c.1318G>T	c.(1318-1320)GGC>TGC	p.G440C		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	440					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		GACTGGGAGCCAGAGAGTGTG	0.572			NA											5	5					5.9392e-07	7.4158e-07	0.001168	1	0
LAMA1	284217	broad.mit.edu	37	18	6943237	6943237	+	Silent	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr18:6943237T>C	uc002knm.2	-	62	9103	c.9009A>G	c.(9007-9009)CCA>CCG	p.P3003P	LAMA1_uc002knk.2_Silent_p.P333P|LAMA1_uc002knl.2_Silent_p.P456P|LAMA1_uc010wzj.1_Silent_p.P2479P	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	3003	Laminin G-like 5.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACTGGGTGTGTGGACTTTCAG	0.493			NA											36	50					0	0	0.004289	0	0
KIAA0802	23255	broad.mit.edu	37	18	8783547	8783547	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr18:8783547G>T	uc002knr.2	+	6	579	c.437G>T	c.(436-438)AGG>ATG	p.R146M	KIAA0802_uc002knq.2_Missense_Mutation_p.R146M|KIAA0802_uc010dkw.1_Translation_Start_Site	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	497											0						GCCGATTTGAGGTGCCAGCTC	0.517			NA											8	11					3.09899e-07	3.91998e-07	0.004482	1	0
PTPN2	5771	broad.mit.edu	37	18	12814257	12814257	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr18:12814257G>A	uc002krp.2	-	7	997	c.803C>T	c.(802-804)TCA>TTA	p.S268L	PTPN2_uc002krl.2_Missense_Mutation_p.S268L|PTPN2_uc002krn.2_Missense_Mutation_p.S291L|PTPN2_uc002kro.2_Missense_Mutation_p.S268L|PTPN2_uc002krm.2_Missense_Mutation_p.S268L	NM_002828	NP_002819	P17706	PTN2_HUMAN	protein tyrosine phosphatase, non-receptor type	268	Tyrosine-protein phosphatase.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway	endoplasmic reticulum|nucleoplasm	protein binding			skin(2)	2		Lung NSC(161;8.94e-06)				AGCCATGTATGAGAATCTCAG	0.323			NA											9	25					0	0	0.006214	0	0
CDH2	1000	broad.mit.edu	37	18	25573585	25573585	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr18:25573585G>A	uc002kwg.2	-	8	1496	c.1037C>T	c.(1036-1038)ACG>ATG	p.T346M	CDH2_uc010xbn.1_Missense_Mutation_p.T315M	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	346	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						AATTATTAACGTATACTGTTG	0.373			NA											55	68					0	0	0.01441	0	0
DSC3	1825	broad.mit.edu	37	18	28602364	28602364	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr18:28602364G>C	uc002kwj.3	-	7	1035	c.880C>G	c.(880-882)CTC>GTC	p.L294V	DSC3_uc002kwi.3_Missense_Mutation_p.L294V	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	294	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			ACAGAAAAGAGCCCAGGTGAC	0.498			NA											26	48					0	0	0.003954	0	0
ST8SIA5	29906	broad.mit.edu	37	18	44266155	44266155	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr18:44266155C>G	uc002lcj.1	-	5	1119	c.551G>C	c.(550-552)AGC>ACC	p.S184T	ST8SIA5_uc002lci.1_Missense_Mutation_p.S31T|ST8SIA5_uc010xcy.1_Missense_Mutation_p.S220T|ST8SIA5_uc010xcz.1_Missense_Mutation_p.S153T	NM_013305	NP_037437	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide	184	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						GAAGTCGGCGCTGTTGATCTC	0.577			NA											11	20					0	0	0.013537	0	0
DOT1L	84444	broad.mit.edu	37	19	2216346	2216346	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:2216346C>G	uc002lvb.3	+	20	2026	c.1990C>G	c.(1990-1992)CCG>GCG	p.P664A	DOT1L_uc002lvc.1_5'UTR|uc002lvd.1_5'Flank|DOT1L_uc002lve.1_5'UTR	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	664						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCCTGTGTGCCGCCTGACGA	0.677			NA											12	27					0	0	0.013537	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2396584	2396584	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:2396584C>T	uc010xgx.1	+	2	190	c.190C>T	c.(190-192)CGG>TGG	p.R64W	TMPRSS9_uc002lvv.1_Missense_Mutation_p.R64W	NM_182973	NP_892018	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	64	Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCGAGCTGCGGGGAATCCG	0.662			NA											6	4					0	0	0.001168	0	0
PLIN4	729359	broad.mit.edu	37	19	4512005	4512005	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:4512005G>T	uc002mar.1	-	3	1925	c.1925C>A	c.(1924-1926)ACC>AAC	p.T642N	PLIN4_uc010dub.1_5'Flank	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	642	27 X 33 AA approximate tandem repeat.|17.					lipid particle|plasma membrane					0						GATATTTTGGGTCGTTTTCAG	0.562			NA											48	86					1.89013e-27	3.36353e-27	0.01441	1	0
SAFB2	9667	broad.mit.edu	37	19	5587938	5587938	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:5587938C>A	uc002mcd.2	-	19	2791	c.2579G>T	c.(2578-2580)CGC>CTC	p.R860L		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	860	Interacts with SAFB1.|Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		CTGCCAGGCGCGTGCCTGGTG	0.667	Ovarian(127;888 1728 23957 44128 52668)		NA											7	9					1.12685e-05	1.32181e-05	0.004482	1	0
FBN3	84467	broad.mit.edu	37	19	8131064	8131064	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:8131064G>A	uc002mjf.2	-	63	8190	c.8169C>T	c.(8167-8169)ATC>ATT	p.I2723I	FBN3_uc002mje.2_Silent_p.I519I	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2723						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GGAGCTCCAGGATGCGCTCGG	0.652			NA											10	12					0	0	0.010729	0	0
ZNF266	10781	broad.mit.edu	37	19	9524200	9524200	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:9524200C>A	uc002mll.2	-	4	1667	c.1401G>T	c.(1399-1401)ATG>ATT	p.M467I	ZNF266_uc002mlm.2_Missense_Mutation_p.M467I|ZNF266_uc002mln.2_Missense_Mutation_p.M467I|ZNF266_uc002mlo.2_Missense_Mutation_p.M467I|ZNF266_uc010dwp.2_Missense_Mutation_p.M467I|ZNF266_uc010dwq.2_Missense_Mutation_p.M467I	NM_198058	NP_932175	Q14584	ZN266_HUMAN	zinc finger protein 266	467	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGCCACATTCCATACACGTGA	0.448			NA											8	29					0.00448238	0.00483156	0.004482	1	0
ZNF560	147741	broad.mit.edu	37	19	9578911	9578911	+	Nonsense_Mutation	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:9578911T>A	uc002mlp.1	-	10	922	c.712A>T	c.(712-714)AGA>TGA	p.R238*	ZNF560_uc010dwr.1_Nonsense_Mutation_p.R132*	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	238					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						GTGTTGCCTCTATTTTGAGTA	0.388			NA											41	38					0	0	0.006999	0	0
SMARCA4	6597	broad.mit.edu	37	19	11105642	11105642	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:11105642G>T	uc002mqf.3	+	9	1842	c.1558G>T	c.(1558-1560)GAG>TAG	p.E520*	SMARCA4_uc010dxp.2_Nonsense_Mutation_p.E520*|SMARCA4_uc010dxo.2_Nonsense_Mutation_p.E520*|SMARCA4_uc002mqg.1_Nonsense_Mutation_p.E520*|SMARCA4_uc010dxq.2_Nonsense_Mutation_p.E520*|SMARCA4_uc010dxr.2_Nonsense_Mutation_p.E520*|SMARCA4_uc002mqj.3_Nonsense_Mutation_p.E520*|SMARCA4_uc010dxs.2_Nonsense_Mutation_p.E520*|SMARCA4_uc002mqe.2_Nonsense_Mutation_p.E520*	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	520	HSA.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GAAAGAGAACGAGCGGATCGA	0.567			NA	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				9	13					1.12685e-05	1.32181e-05	0.004482	1	0
MYO9B	4650	broad.mit.edu	37	19	17296811	17296811	+	Splice_Site	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:17296811G>T	uc010eak.2	+	18	2729	c.2577_splice	c.e18+1	p.K859_splice	MYO9B_uc002nfi.2_Splice_Site_p.K859_splice|MYO9B_uc002nfj.1_Splice_Site_p.K859_splice	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1						actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						TGCTGAAAAGGTGAGTTTCTC	0.552			NA											25	47					1.08971e-26	1.92905e-26	0.00632	1	0
UNC13A	23025	broad.mit.edu	37	19	17752261	17752261	+	Silent	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:17752261C>T	uc002nhd.2	-	21	2841	c.2841G>A	c.(2839-2841)CAG>CAA	p.Q947Q		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	859					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						CCACAATCTCCTGGGCTGTCT	0.562			NA											19	20					0	0	0.007413	0	0
GATAD2A	54815	broad.mit.edu	37	19	19611940	19611940	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:19611940G>A	uc010xqt.1	+	9	1527	c.1215G>A	c.(1213-1215)TCG>TCA	p.S405S	GATAD2A_uc010xqu.1_Silent_p.S34S|GATAD2A_uc010xqv.1_Silent_p.S425S|GATAD2A_uc010xqw.1_Silent_p.S233S	NM_017660	NP_060130	Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	405					DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GCAGGATGTCGGCCGCCACTG	0.657			NA											4	42					0	0	0.009096	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769817	31769817	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:31769817C>A	uc002nsy.3	-	2	947	c.882G>T	c.(880-882)ATG>ATT	p.M294I		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	294	C2H2-type 2.				negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TTGTTTTGATCATATGGACAC	0.517			NA											36	71					2.20474e-14	3.3973e-14	0.003755	1	0
RHPN2	85415	broad.mit.edu	37	19	33490547	33490547	+	Silent	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:33490547T>A	uc002nuf.2	-	10	1236	c.1170A>T	c.(1168-1170)CCA>CCT	p.P390P	RHPN2_uc010xro.1_Silent_p.P239P|RHPN2_uc002nue.2_Silent_p.P120P	NM_033103	NP_149094	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	390	BRO1.				signal transduction	perinuclear region of cytoplasm	protein binding			central_nervous_system(5)|ovary(1)	6	Esophageal squamous(110;0.137)					TCAGCCCCTCTGGCATGTGGT	0.602			NA											3	18					0	0	0.004672	0	0
ZNF461	92283	broad.mit.edu	37	19	37130585	37130585	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:37130585C>A	uc002oem.2	-	6	890	c.662G>T	c.(661-663)TGT>TTT	p.C221F	ZNF461_uc002oen.2_Missense_Mutation_p.C190F|ZNF461_uc010xtj.1_Missense_Mutation_p.C198F	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	221					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GCATTCTTTACATTCAGAAAG	0.313			NA											21	29					6.33239e-15	9.84715e-15	0.010504	1	0
ATP5SL	55101	broad.mit.edu	37	19	41939238	41939238	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:41939238G>C	uc002oqw.1	-	5	541	c.535C>G	c.(535-537)CTC>GTC	p.L179V	CYP2F1_uc010xvw.1_Intron|ATP5SL_uc002oqu.1_RNA|ATP5SL_uc002oqv.2_Missense_Mutation_p.L185V|ATP5SL_uc010xwa.1_Intron|ATP5SL_uc002oqx.1_Missense_Mutation_p.L152V|ATP5SL_uc002oqy.1_Intron|ATP5SL_uc002oqz.1_Intron|ATP5SL_uc002ora.1_Missense_Mutation_p.L166V|ATP5SL_uc010xwb.1_Missense_Mutation_p.L158V	NM_018035	NP_060505	Q9NW81	AT5SL_HUMAN	ATP5S-like	179										large_intestine(1)|breast(1)	2						GCCAGCGAGAGCTCCTGCAAC	0.682			NA											7	31					0	0	0.001984	0	0
TMEM145	284339	broad.mit.edu	37	19	42827820	42827820	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:42827820C>A	uc002otk.1	+	14	1332	c.1280C>A	c.(1279-1281)CCC>CAC	p.P427H	MEGF8_uc002otl.3_5'Flank	NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	427						integral to membrane					0		Prostate(69;0.00682)				GTCCCTGGACCCGGAGGGAGC	0.622			NA											19	25					4.96729e-08	6.42714e-08	0.008871	1	0
PSG6	5675	broad.mit.edu	37	19	43420611	43420611	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:43420611G>A	uc002ovj.1	-	2	145	c.93C>T	c.(91-93)CCC>CCT	p.P31P	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG6_uc002ovf.1_Silent_p.P31P|PSG6_uc002ovg.1_Silent_p.P31P	NM_002782	NP_002773	Q00889	PSG6_HUMAN	pregnancy specific beta-1-glycoprotein 6 isoform	31					female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				GGGCAGTGGTGGGCAGGTTCC	0.468			NA											82	102					0	0	0.01441	0	0
ZNF235	9310	broad.mit.edu	37	19	44792248	44792248	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:44792248T>C	uc002oza.3	-	5	1443	c.1340A>G	c.(1339-1341)CAT>CGT	p.H447R	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF235_uc002ozb.3_Missense_Mutation_p.H443R|ZNF235_uc010xwx.1_Missense_Mutation_p.H361R	NM_004234	NP_004225	Q14590	ZN235_HUMAN	zinc finger protein 93 homolog	447	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)	3		Prostate(69;0.0352)|all_neural(266;0.116)				CTGATGGGTATGAAGATTTGA	0.398			NA											37	47					0	0	0.005524	0	0
GPR4	2828	broad.mit.edu	37	19	46094361	46094361	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:46094361G>T	uc002pcm.2	-	2	1709	c.764C>A	c.(763-765)CCC>CAC	p.P255H	OPA3_uc010xxk.1_Intron	NM_005282	NP_005273	P46093	GPR4_HUMAN	G protein-coupled receptor 4	255	Extracellular (Potential).			P -> L (in Ref. 5; BAF83387).		integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		GCAGTCCCAGGGGCGGCCCAG	0.627	Esophageal Squamous(117;181 1612 1673 14956 42937)		NA											14	32					1.5842e-08	2.09374e-08	0.001855	1	0
CCDC61	729440	broad.mit.edu	37	19	46509878	46509878	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:46509878G>T	uc002pdw.2	+	5	464	c.464G>T	c.(463-465)CGC>CTC	p.R155L		NM_001080402	NP_001073871			coiled-coil domain containing 61									p.R155S(1)		ovary(1)	1		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00221)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.164)		CTGCGGAACCGCAAGATGGGG	0.632			NA											17	18					9.16793e-09	1.22601e-08	0.00499	1	0
MEIS3	56917	broad.mit.edu	37	19	47912735	47912735	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:47912735C>T	uc002pgu.2	-	7	1114	c.667G>A	c.(667-669)GGG>AGG	p.G223R	MEIS3_uc010xyp.1_5'Flank|MEIS3_uc002pgo.2_Missense_Mutation_p.G22R|MEIS3_uc002pgp.2_Missense_Mutation_p.G55R|MEIS3_uc002pgq.2_Missense_Mutation_p.G304R|MEIS3_uc002pgr.2_Missense_Mutation_p.G91R|MEIS3_uc002pgt.2_Missense_Mutation_p.G206R|MEIS3_uc002pgv.2_Missense_Mutation_p.G206R|MEIS3_uc002pgs.2_Missense_Mutation_p.G223R|MEIS3_uc010eld.2_Missense_Mutation_p.G223R	NM_001009813	NP_001009813	Q99687	MEIS3_HUMAN	Meis1, myeloid ecotropic viral integration site	223	Ser/Thr-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000198)|OV - Ovarian serous cystadenocarcinoma(262;0.000439)|Epithelial(262;0.0113)|GBM - Glioblastoma multiforme(486;0.0223)		GCCAGGCCCCCACTGGATGGA	0.502			NA											23	37					0	0	0.003954	0	0
ELSPBP1	64100	broad.mit.edu	37	19	48519179	48519179	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:48519179T>A	uc002pht.2	+	4	393	c.238T>A	c.(238-240)TAT>AAT	p.Y80N		NM_022142	NP_071425	Q96BH3	ESPB1_HUMAN	epididymal sperm binding protein 1 precursor	80	Fibronectin type-II 2.				single fertilization	extracellular region					0		all_cancers(25;8.7e-09)|all_lung(116;1.15e-06)|all_epithelial(76;1.17e-06)|Lung NSC(112;2.56e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000253)|all cancers(93;0.00129)|Epithelial(262;0.0314)|GBM - Glioblastoma multiforme(486;0.0606)		CCCTTTCATCTATCGAGGAAA	0.468			NA											26	29					0	0	0.004656	0	0
PRMT1	3276	broad.mit.edu	37	19	50189881	50189881	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:50189881G>T	uc010enf.1	+	10	972	c.930G>T	c.(928-930)ACG>ACT	p.T310T	PRMT1_uc002ppc.1_RNA|PRMT1_uc002ppd.2_Silent_p.T286T|PRMT1_uc002ppe.2_Silent_p.T292T|PRMT1_uc002ppf.2_RNA|PRMT1_uc002ppg.2_Silent_p.T257T|PRMT1_uc010ybb.1_5'Flank|C19orf76_uc002pph.2_5'Flank	NM_001536	NP_001527	Q8WUW5	Q8WUW5_HUMAN	HMT1 hnRNP methyltransferase-like 2 isoform 1	291						cytoplasm	protein methyltransferase activity			ovary(1)	1		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00103)|GBM - Glioblastoma multiforme(134;0.012)		CCCCGTACACGCACTGGAAGC	0.677			NA											16	18					1.15088e-07	1.47225e-07	0.004007	1	0
LILRB2	10288	broad.mit.edu	37	19	54780746	54780746	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:54780746C>A	uc002qfb.2	-	10	1664	c.1398G>T	c.(1396-1398)TTG>TTT	p.L466F	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.L466F|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.L465F|LILRB2_uc010yet.1_Missense_Mutation_p.L350F	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	466	Helical; (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CGACGGCCACCAAGATGCCGA	0.393			NA											19	32					1.45105e-14	2.24103e-14	0.006122	1	0
USP29	57663	broad.mit.edu	37	19	57640280	57640280	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:57640280C>A	uc002qny.2	+	4	593	c.237C>A	c.(235-237)AAC>AAA	p.N79K		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	79					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGAAAAACAACGTGTTCTTGT	0.333			NA											10	18					0.000673444	0.00074607	0.008291	1	0
RSAD2	91543	broad.mit.edu	37	2	7035912	7035912	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:7035912C>A	uc002qyp.1	+	6	1061	c.925C>A	c.(925-927)CGC>AGC	p.R309S		NM_080657	NP_542388	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing	309					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		TTTCTAGATGCGCTTTCTGAA	0.368			NA											8	41					0.00307968	0.00334084	0.00308	1	0
ROCK2	9475	broad.mit.edu	37	2	11484250	11484250	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:11484250G>A	uc002rbd.1	-	1	462	c.13C>T	c.(13-15)CCG>TCG	p.P5S		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	5					axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		CCCGTCGGCGGGGGCCGGCTC	0.766			NA											3	5					0	0	0.009096	0	0
MYCN	4613	broad.mit.edu	37	2	16082194	16082194	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:16082194G>T	uc002rci.2	+	2	308	c.8G>T	c.(7-9)AGC>ATC	p.S3I	MYCNOS_uc002rch.1_5'Flank|MYCN_uc010yjr.1_5'UTR	NM_005378	NP_005369	P04198	MYCN_HUMAN	v-myc myelocytomatosis viral related oncogene,	3					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			CCGATGCCGAGCTGCTCCACG	0.632			NA	A		neuroblastoma								5	25					3.59834e-05	4.1491e-05	0.001168	1	0
RAD51AP2	729475	broad.mit.edu	37	2	17696481	17696481	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:17696481G>T	uc002rcl.1	-	1	3226	c.3202C>A	c.(3202-3204)CCA>ACA	p.P1068T	RAD51AP2_uc010exn.1_Missense_Mutation_p.P1059T	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	1068										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GATCTACTTGGATAACAACTC	0.323			NA											4	20					0.00909568	0.00968112	0.009096	1	0
ITSN2	50618	broad.mit.edu	37	2	24443819	24443819	+	Missense_Mutation	SNP	C	C	A	rs150580767		TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:24443819C>A	uc002rfe.2	-	30	3952	c.3694G>T	c.(3694-3696)GTC>TTC	p.V1232F	ITSN2_uc002rff.2_Missense_Mutation_p.V1205F|ITSN2_uc002rfg.2_Missense_Mutation_p.V1232F	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	1232	DH.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTCACCTCGACGACGAGCTGA	0.552			NA											18	137					6.49762e-13	9.53547e-13	0.006122	1	0
ALK	238	broad.mit.edu	37	2	29498008	29498008	+	Silent	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:29498008G>C	uc002rmy.2	-	11	2905	c.1998C>G	c.(1996-1998)CCC>CCG	p.P666P		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	666	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity	p.P666L(1)	NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	AATTTTCCCCGGGTTTCAGCT	0.463			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				13	54					0	0	0.003163	0	0
ALK	238	broad.mit.edu	37	2	29498359	29498359	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:29498359G>A	uc002rmy.2	-	10	2728	c.1821C>T	c.(1819-1821)TTC>TTT	p.F607F		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	607	MAM 2.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TCTGCAGCCAGAACCTGTACA	0.527			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				26	47					0	0	0.00632	0	0
LTBP1	4052	broad.mit.edu	37	2	33246225	33246225	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:33246225C>A	uc002ros.2	+	3	815	c.815C>A	c.(814-816)ACC>AAC	p.T272N		NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	272					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				ATGACCTTAACCCTCAAGCCG	0.498			NA											16	88					6.49762e-13	9.53547e-13	0.006122	1	0
MYADML	151325	broad.mit.edu	37	2	33952176	33952176	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:33952176T>A	uc002rpb.2	-	1	1109	c.667A>T	c.(667-669)ACG>TCG	p.T223S		NR_003143				RecName: Full=Myeloid-associated differentiation marker-like protein.;												0						TTGACGGCCGTCAGGTTGGTC	0.587			NA											5	5					0	0	0.001168	0	0
PSME4	23198	broad.mit.edu	37	2	54114547	54114547	+	Silent	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:54114547T>A	uc002rxp.2	-	40	4634	c.4578A>T	c.(4576-4578)ATA>ATT	p.I1526I	PSME4_uc010yop.1_Silent_p.I1412I|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_Silent_p.I901I|PSME4_uc010fbv.1_Silent_p.I670I|PSME4_uc010fbt.1_Silent_p.I13I	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	1526					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			CATGAGGCGATATGGTTGGTG	0.378			NA											9	35					0	0	0.004482	0	0
ZNF638	27332	broad.mit.edu	37	2	71577285	71577285	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:71577285G>T	uc002shx.2	+	2	1520	c.1201G>T	c.(1201-1203)GCC>TCC	p.A401S	ZNF638_uc010fec.2_Missense_Mutation_p.A507S|ZNF638_uc010yqw.1_Intron|ZNF638_uc002shw.2_Missense_Mutation_p.A401S|ZNF638_uc002shy.2_Missense_Mutation_p.A401S|ZNF638_uc002shz.2_Missense_Mutation_p.A401S|ZNF638_uc002sia.2_Missense_Mutation_p.A401S|ZNF638_uc002sib.1_Missense_Mutation_p.A401S	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	401					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						ACATGCTGATGCCCAGAAGAT	0.408			NA											20	120					1.00905e-13	1.52708e-13	0.008871	1	0
C2orf78	388960	broad.mit.edu	37	2	74043796	74043796	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:74043796A>G	uc002sjr.1	+	3	2567	c.2446A>G	c.(2446-2448)AAA>GAA	p.K816E		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	816										ovary(2)	2						ATCAGCCTACAAAACATCATC	0.343			NA											6	32					0	0	0.001168	0	0
Unknown	0	broad.mit.edu	37	2	89417281	89417281	+	Splice_Site	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:89417281G>A	uc010ytr.1	-	41		c.4448_splice	c.e41-1		uc002stl.2_Intron					Parts of antibodies, mostly variable regions.												NA						AGGAGCCCCAGGAGCTGAGCG	0.537			NA											6	234					0	0	0.008291	0	0
TMEM131	23505	broad.mit.edu	37	2	98392318	98392318	+	Silent	SNP	C	C	T	rs61745536	by1000genomes	TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:98392318C>T	uc002syh.3	-	32	4537	c.4308G>A	c.(4306-4308)CCG>CCA	p.P1436P		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	1436	Lys-rich.					integral to membrane				ovary(4)|central_nervous_system(2)	6						CCTTGAGGAGCGGTTCTGTGT	0.517			NA											4	28					0	0	0.009096	0	0
NPHP1	4867	broad.mit.edu	37	2	110917777	110917777	+	Missense_Mutation	SNP	A	A	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:110917777A>C	uc002tfn.3	-	11	1269	c.1175T>G	c.(1174-1176)ATG>AGG	p.M392R	NPHP1_uc002tfm.3_Missense_Mutation_p.M337R|NPHP1_uc002tfl.3_Missense_Mutation_p.M393R|NPHP1_uc002tfo.3_Missense_Mutation_p.M274R|NPHP1_uc010ywx.1_Missense_Mutation_p.M336R|NPHP1_uc010fjv.1_Missense_Mutation_p.M336R	NM_207181	NP_997064	O15259	NPHP1_HUMAN	nephrocystin 1 isoform 2	392					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			ovary(2)	2						AAGAGGAATCATTTTACAGCT	0.333			NA											5	108					0	0	0.001168	0	0
ZC3H6	376940	broad.mit.edu	37	2	113089652	113089652	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:113089652G>T	uc002thq.1	+	12	3551	c.3157G>T	c.(3157-3159)GAT>TAT	p.D1053Y		NM_198581	NP_940983	P61129	ZC3H6_HUMAN	zinc finger CCCH-type domain containing 6	1053							nucleic acid binding|zinc ion binding			ovary(3)|central_nervous_system(1)	4						TGACCCTAGGGATCACGGTTC	0.453			NA											11	31					0.000673444	0.00074607	0.008291	1	0
SLC20A1	6574	broad.mit.edu	37	2	113417307	113417307	+	Silent	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:113417307T>C	uc002tib.2	+	8	2021	c.1575T>C	c.(1573-1575)TTT>TTC	p.F525F	SLC20A1_uc002tic.1_Silent_p.F337F	NM_005415	NP_005406	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate	525	Helical; (Potential).				phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			ovary(2)	2						CAGCCTGCTTTGGGTCATTCG	0.448			NA											55	92					0	0	0.01441	0	0
PTPN4	5775	broad.mit.edu	37	2	120725423	120725423	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:120725423G>A	uc002tmf.1	+	26	3340	c.2569G>A	c.(2569-2571)GGA>AGA	p.G857R	PTPN4_uc010flj.1_Missense_Mutation_p.G570R|PTPN4_uc010yyr.1_Missense_Mutation_p.G490R	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	857	Tyrosine-protein phosphatase.|Substrate binding (By similarity).					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	TGCTGGAATCGGAAGAACTGG	0.358			NA											38	90					0	0	0.006999	0	0
GLI2	2736	broad.mit.edu	37	2	121554950	121554950	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:121554950G>T	uc010flp.2	+	1	84	c.54G>T	c.(52-54)GGG>GGT	p.G18G	GLI2_uc010yyu.1_Silent_p.G18G|GLI2_uc002tmp.1_Silent_p.G18G|GLI2_uc010fln.1_RNA|GLI2_uc002tmq.1_5'UTR|GLI2_uc002tmr.1_5'UTR|GLI2_uc002tmt.3_5'UTR|GLI2_uc002tmu.3_5'UTR|GLI2_uc002tmv.1_Silent_p.G18G|GLI2_uc010flo.1_5'UTR|GLI2_uc002tmw.1_Silent_p.G18G	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	18					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				CCAAAAGTGGGATCCTGGAGG	0.592			NA											55	100					3.76525e-18	6.16627e-18	0.01441	1	0
GLI2	2736	broad.mit.edu	37	2	121708821	121708821	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:121708821C>A	uc010flp.2	+	3	287	c.257C>A	c.(256-258)CCC>CAC	p.P86H	GLI2_uc010yyu.1_Missense_Mutation_p.P86H|GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Intron|GLI2_uc002tmu.3_Intron|GLI2_uc002tmv.1_Intron|GLI2_uc010flo.1_5'UTR|GLI2_uc002tmw.1_Missense_Mutation_p.P86H	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	86					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				CTCTGCAGGCCCCCTGCCCTC	0.622			NA											47	116					3.76343e-11	5.30479e-11	0.01441	1	0
MYO7B	4648	broad.mit.edu	37	2	128346070	128346070	+	Silent	SNP	A	A	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:128346070A>G	uc002top.2	+	15	1847	c.1794A>G	c.(1792-1794)GCA>GCG	p.A598A		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	598	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TGGAGTTAGCAGAGACCAAGC	0.542			NA											12	71					0	0	0.001855	0	0
PLEKHB2	55041	broad.mit.edu	37	2	131883346	131883346	+	Nonsense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:131883346A>T	uc002tsg.3	+	3	618	c.58A>T	c.(58-60)AAG>TAG	p.K20*	PLEKHB2_uc002tsh.2_Nonsense_Mutation_p.K20*|PLEKHB2_uc002tsj.3_Nonsense_Mutation_p.K20*|PLEKHB2_uc002tsf.3_Nonsense_Mutation_p.K20*|PLEKHB2_uc010zao.1_5'UTR|PLEKHB2_uc010zap.1_Nonsense_Mutation_p.K20*|PLEKHB2_uc010zaq.1_Nonsense_Mutation_p.K20*|PLEKHB2_uc002tsi.3_Nonsense_Mutation_p.K61*	NM_001100623	NP_001094093	Q96CS7	PKHB2_HUMAN	pleckstrin homology domain containing, family B	20	PH.					membrane	protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.0828)		GAAGCGCTGGAAGAAGAACTG	0.313			NA											9	31					0	0	0.004482	0	0
NCKAP5	344148	broad.mit.edu	37	2	133541592	133541592	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:133541592G>T	uc002ttp.2	-	14	3166	c.2792C>A	c.(2791-2793)CCC>CAC	p.P931H	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	931	Poly-Pro.			PP -> QS (in Ref. 5; BAA22433).			protein binding				0						GCCTGGAGGGGGCGGAGGGGA	0.622			NA											8	30					0.00307968	0.00334084	0.00308	1	0
THSD7B	80731	broad.mit.edu	37	2	138169390	138169390	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:138169390C>A	uc002tva.1	+	13	2814	c.2814C>A	c.(2812-2814)GCC>GCA	p.A938A	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Silent_p.A828A	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GAGCAGTAGCCTGTTCTGATA	0.512			NA											22	46					7.41877e-09	9.96025e-09	0.012319	1	0
LRP1B	53353	broad.mit.edu	37	2	141625343	141625343	+	Silent	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:141625343A>T	uc002tvj.1	-	27	5367	c.4395T>A	c.(4393-4395)GGT>GGA	p.G1465G	LRP1B_uc010fnl.1_Silent_p.G647G	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1465	Extracellular (Potential).|LDL-receptor class B 12.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGTATTCATGACCTCGGATGA	0.408	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			40	57					0	0	0.00874	0	0
SCN7A	6332	broad.mit.edu	37	2	167322326	167322326	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:167322326A>T	uc002udu.1	-	7	963	c.836T>A	c.(835-837)CTG>CAG	p.L279Q	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	279					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						TCTGTTGTGCAGGGTTTCATT	0.383			NA											16	93					0	0	0.004007	0	0
G6PC2	57818	broad.mit.edu	37	2	169763212	169763212	+	Missense_Mutation	SNP	T	T	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:169763212T>G	uc002uem.2	+	4	571	c.479T>G	c.(478-480)ATT>AGT	p.I160S	G6PC2_uc002uen.2_Intron|G6PC2_uc010fpv.2_Missense_Mutation_p.I44S	NM_021176	NP_066999	Q9NQR9	G6PC2_HUMAN	islet-specific glucose-6-phosphatase-related	160	Helical; (Potential).				gluconeogenesis|glucose homeostasis|glucose transport|regulation of insulin secretion|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			pancreas(1)	1						TTTTGGTTGATTCAAATCAGT	0.343			NA											38	65					0	0	0.00623	0	0
LRP2	4036	broad.mit.edu	37	2	170063626	170063626	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:170063626T>C	uc002ues.2	-	39	6817	c.6604A>G	c.(6604-6606)AGA>GGA	p.R2202G		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2202	LDL-receptor class B 22.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AAGAGGTATCTGTTCTTGGGA	0.458			NA											27	127					0	0	0.009535	0	0
SCRN3	79634	broad.mit.edu	37	2	175268882	175268882	+	Missense_Mutation	SNP	G	G	A	rs140532560		TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:175268882G>A	uc002uiq.2	+	5	681	c.593G>A	c.(592-594)CGG>CAG	p.R198Q	SCRN3_uc010zen.1_Missense_Mutation_p.R191Q|SCRN3_uc010zeo.1_5'UTR	NM_024583	NP_078859	Q0VDG4	SCRN3_HUMAN	secernin 3	198					proteolysis		dipeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.229)			AAGATTGCCCGGGAACACCCA	0.398			NA											4	39					0	0	0.000602	0	0
NEUROD1	4760	broad.mit.edu	37	2	182543486	182543486	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:182543486G>A	uc002uof.2	-	2	338	c.102C>T	c.(100-102)CAC>CAT	p.H34H	CERKL_uc002uod.1_Intron	NM_002500	NP_002491	Q13562	NDF1_HUMAN	neurogenic differentiation 1	34					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TGTCTGCCTCGTGCTCCTCGT	0.498			NA											5	16					0	0	0.000602	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802769	185802769	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:185802769C>A	uc002uph.2	+	4	3240	c.2646C>A	c.(2644-2646)CAC>CAA	p.H882Q		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	882						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TGTCTTTCCACCCTAACAATC	0.373			NA											28	58					3.1745e-13	4.70965e-13	0.008361	1	0
ZSWIM2	151112	broad.mit.edu	37	2	187692918	187692918	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:187692918C>A	uc002upu.1	-	9	1735	c.1695G>T	c.(1693-1695)GAG>GAT	p.E565D		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	565					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			TCTTGTTGTCCTCTCTTATTT	0.378			NA											12	36					1.5842e-08	2.09374e-08	0.001855	1	0
COL3A1	1281	broad.mit.edu	37	2	189856407	189856407	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:189856407G>C	uc002uqj.1	+	13	1027	c.910G>C	c.(910-912)GCT>CCT	p.A304P	COL3A1_uc010frw.1_RNA	NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	304	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TCCAAGAGGGGCTCCTGGTGA	0.463			NA											21	166					0	0	0.00333	0	0
HIBCH	26275	broad.mit.edu	37	2	191159310	191159310	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:191159310G>A	uc002uru.2	-	4	349	c.266C>T	c.(265-267)GCA>GTA	p.A89V	HIBCH_uc002urv.2_Missense_Mutation_p.A89V	NM_014362	NP_055177	Q6NVY1	HIBCH_HUMAN	3-hydroxyisobutyryl-Coenzyme A hydrolase isoform	89					branched chain family amino acid catabolic process	mitochondrial matrix	3-hydroxyisobutyryl-CoA hydrolase activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000586)|Epithelial(96;0.0286)|all cancers(119;0.0814)			CTTTCCTCCTGCTCCCTTTAT	0.398			NA											21	41					0	0	0.004656	0	0
SDPR	8436	broad.mit.edu	37	2	192700895	192700895	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:192700895G>A	uc002utb.2	-	2	1362	c.1032C>T	c.(1030-1032)AGC>AGT	p.S344S		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	344						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	CCACCAGAGCGCTGGCGAGGG	0.562			NA											52	98					0	0	0.01441	0	0
SDPR	8436	broad.mit.edu	37	2	192701129	192701129	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:192701129C>G	uc002utb.2	-	2	1128	c.798G>C	c.(796-798)GAG>GAC	p.E266D		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	266	Potential.					caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TCTCTCTCCTCTCTACAGATA	0.453			NA											111	207					0	0	0.01441	0	0
CLK1	1195	broad.mit.edu	37	2	201726036	201726036	+	Silent	SNP	A	A	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:201726036A>G	uc002uwe.2	-	3	496	c.315T>C	c.(313-315)TCT>TCC	p.S105S	CLK1_uc010zhi.1_Silent_p.S147S|CLK1_uc002uwf.2_5'UTR|CLK1_uc002uwg.2_5'UTR|CLK1_uc010fsv.2_RNA	NM_004071	NP_004062	P49759	CLK1_HUMAN	CDC-like kinase 1 isoform 1	105					cell proliferation	nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity	p.S105S(1)		pancreas(2)	2						CACTTCTACCAGAAGACTTGC	0.408			NA											52	120					0	0	0.01441	0	0
ADAM23	8745	broad.mit.edu	37	2	207436511	207436511	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:207436511G>T	uc002vbq.2	+	17	1850	c.1627G>T	c.(1627-1629)GGG>TGG	p.G543W	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	543	Disintegrin.|Extracellular (Potential).				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		CTGCAGCGACGGGCCCTGCTG	0.443	Melanoma(194;1127 2130 19620 24042 27855)		NA											23	37					2.21704e-12	3.20501e-12	0.00278	1	0
C2orf80	389073	broad.mit.edu	37	2	209045986	209045986	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:209045986C>G	uc002vcr.2	-	5	422	c.250G>C	c.(250-252)GAA>CAA	p.E84Q		NM_001099334	NP_001092804	Q0P641	CB080_HUMAN	hypothetical protein LOC389073	84										skin(1)	1						GCTTCTCGTTCTCTACGATTT	0.348			NA											24	40					0	0	0.00278	0	0
ERBB4	2066	broad.mit.edu	37	2	212522492	212522492	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:212522492G>T	uc002veg.1	-	16	2031	c.1933C>A	c.(1933-1935)CCA>ACA	p.P645T	ERBB4_uc002veh.1_Missense_Mutation_p.P645T|ERBB4_uc010zji.1_Intron|ERBB4_uc010zjj.1_Intron|ERBB4_uc010fut.1_Missense_Mutation_p.P645T	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	645	Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GCATGTTGTGGTAAAGTGGAA	0.408			NA								TSP Lung(8;0.080)			13	110					1.52009e-12	2.21639e-12	0.003163	1	0
IKZF2	22807	broad.mit.edu	37	2	213886733	213886733	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:213886733C>G	uc002vem.2	-	6	865	c.696G>C	c.(694-696)CAG>CAC	p.Q232H	IKZF2_uc010fuu.2_Missense_Mutation_p.Q87H|IKZF2_uc002vej.2_Missense_Mutation_p.Q179H|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Missense_Mutation_p.Q206H|IKZF2_uc002vel.2_Missense_Mutation_p.Q153H|IKZF2_uc010fuw.2_Missense_Mutation_p.Q6H|IKZF2_uc010fux.2_Missense_Mutation_p.Q6H|IKZF2_uc010fuy.2_Intron|IKZF2_uc002ven.2_Missense_Mutation_p.Q206H	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	232					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		GACTCATGACCTGCCCAGCAG	0.458			NA											31	60					0	0	0.009535	0	0
TNS1	7145	broad.mit.edu	37	2	218713343	218713343	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:218713343G>A	uc002vgt.2	-	17	1920	c.1522C>T	c.(1522-1524)CAG>TAG	p.Q508*	TNS1_uc002vgr.2_Nonsense_Mutation_p.Q508*|TNS1_uc002vgs.2_Nonsense_Mutation_p.Q508*|TNS1_uc010zjv.1_Nonsense_Mutation_p.Q508*|TNS1_uc010fvj.1_Nonsense_Mutation_p.Q576*|TNS1_uc010fvk.1_Nonsense_Mutation_p.Q633*|TNS1_uc010fvi.1_Nonsense_Mutation_p.Q195*	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	508						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TGACCATCCTGGTTTGGCAAT	0.607			NA											17	60					0	0	0.00499	0	0
PTPRN	5798	broad.mit.edu	37	2	220164027	220164027	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:220164027C>A	uc002vkz.2	-	11	1692	c.1603G>T	c.(1603-1605)GGG>TGG	p.G535W	PTPRN_uc010zlc.1_Missense_Mutation_p.G445W|PTPRN_uc002vla.2_Missense_Mutation_p.G506W	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	535	Extracellular (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		AGATATTTACCTGCTTGTTGG	0.547			NA									OREG0015221	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	94					2.23348e-06	2.70895e-06	0.004007	1	0
IRS1	3667	broad.mit.edu	37	2	227662710	227662710	+	Missense_Mutation	SNP	T	T	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:227662710T>G	uc002voh.3	-	1	797	c.745A>C	c.(745-747)ATG>CTG	p.M249L		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	249	IRS-type PTB.				fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		GTCTCGTGCATGTTCTGGGCC	0.607			NA									OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	70					0	0	0.00499	0	0
SPHKAP	80309	broad.mit.edu	37	2	228883814	228883814	+	Missense_Mutation	SNP	T	T	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:228883814T>G	uc002vpq.2	-	7	1803	c.1756A>C	c.(1756-1758)AGT>CGT	p.S586R	SPHKAP_uc002vpp.2_Missense_Mutation_p.S586R|SPHKAP_uc010zlx.1_Missense_Mutation_p.S586R	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	586						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		AGGCTACCACTTGGAGCCACT	0.562			NA											11	41					0	0	0.008291	0	0
SPHKAP	80309	broad.mit.edu	37	2	229046284	229046284	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:229046284T>A	uc002vpq.2	-	1	78	c.31A>T	c.(31-33)AGC>TGC	p.S11C	SPHKAP_uc002vpp.2_Missense_Mutation_p.S11C|SPHKAP_uc010zlx.1_Missense_Mutation_p.S11C	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	11						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GGGTCTTACCTTGGTACCGAG	0.547			NA											29	135					0	0	0.007291	0	0
SP100	6672	broad.mit.edu	37	2	231311581	231311581	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:231311581G>T	uc002vqt.2	+	5	628	c.487G>T	c.(487-489)GAG>TAG	p.E163*	SP100_uc002vqs.2_Nonsense_Mutation_p.E163*|SP100_uc002vqu.1_Nonsense_Mutation_p.E163*|SP100_uc010zmb.1_Nonsense_Mutation_p.E163*|SP100_uc002vqq.1_Nonsense_Mutation_p.E163*|SP100_uc002vqr.1_Nonsense_Mutation_p.E138*|SP100_uc010zmc.1_Nonsense_Mutation_p.E138*|SP100_uc002vqv.1_Nonsense_Mutation_p.E127*	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	163	Poly-Glu.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGAAGAGAGGGAGGAGAGGTC	0.438			NA											3	14					0.00024832	0.000278283	0.009096	1	0
DGKD	8527	broad.mit.edu	37	2	234365975	234365975	+	Splice_Site	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr2:234365975G>C	uc002vui.1	+	21	2592	c.2580_splice	c.e21+1	p.D860_splice	DGKD_uc002vuj.1_Splice_Site_p.D816_splice|DGKD_uc010fyh.1_Missense_Mutation_p.V728L|DGKD_uc010fyi.1_Splice_Site	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	GGAAGATGATGTATGTATGGG	0.582			NA											11	59					0	0	0.008291	0	0
SNAP25	6616	broad.mit.edu	37	20	10280043	10280043	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:10280043G>T	uc002wnq.1	+	7	747	c.535G>T	c.(535-537)GAC>TAC	p.D179Y	SNAP25_uc002wnr.1_Missense_Mutation_p.D179Y|SNAP25_uc002wns.1_Missense_Mutation_p.D116Y|SNAP25_uc010gca.1_Missense_Mutation_p.D179Y|SNAP25_uc010gcb.1_Missense_Mutation_p.D116Y|SNAP25_uc010gcc.1_Missense_Mutation_p.D73Y	NM_130811	NP_570824	P60880	SNP25_HUMAN	synaptosomal-associated protein 25 isoform	179	t-SNARE coiled-coil homology 2.				energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				skin(2)	2					Botulinum Toxin Type A(DB00083)	TCGCCAGATCGACAGGATCAT	0.512			NA											20	29					3.99206e-14	6.09598e-14	0.007413	1	0
ZNF133	7692	broad.mit.edu	37	20	18286371	18286371	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:18286371A>T	uc010gcq.2	+	3	346	c.41A>T	c.(40-42)GAG>GTG	p.E14V	ZNF133_uc010zrv.1_Missense_Mutation_p.E17V|ZNF133_uc010zrw.1_5'UTR|ZNF133_uc010gcr.2_Missense_Mutation_p.E14V|ZNF133_uc010zrx.1_Intron|ZNF133_uc002wql.3_Missense_Mutation_p.E14V|ZNF133_uc010gcs.2_Missense_Mutation_p.E14V|ZNF133_uc010zry.1_Intron|ZNF133_uc002wqm.2_Missense_Mutation_p.E14V	NM_003434	NP_003425	P52736	ZN133_HUMAN	zinc finger protein 133	14	KRAB.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)	2						ACCCAGGATGAGTGGAGGCTG	0.537			NA											16	64					0	0	0.004007	0	0
CD93	22918	broad.mit.edu	37	20	23066072	23066072	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:23066072G>A	uc002wsv.2	-	1	906	c.758C>T	c.(757-759)TCG>TTG	p.S253L		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	253	Extracellular (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GAGGGGGCCCGAGCTGCCCCA	0.602			NA											15	106					0	0	0.003163	0	0
REM1	28954	broad.mit.edu	37	20	30064325	30064326	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:30064325_30064326GG>TT	uc002wwa.2	+	2	361_362	c.77_78GG>TT	c.(76-78)CGG>CTT	p.R26L		NM_014012	NP_054731	O75628	REM1_HUMAN	RAS-like GTP-binding protein REM	26					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			lung(2)|pancreas(2)	4	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CTGTCCCCACGGGGCCACCAGC	0.644			NA											9	49					0	0	0.004672	0	0
DUSP15	128853	broad.mit.edu	37	20	30436290	30436290	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:30436290G>C	uc002wwu.1	-	10	882	c.805C>G	c.(805-807)CCT>GCT	p.P269A	FOXS1_uc002wwt.1_5'Flank			Q9H1R2	DUS15_HUMAN	RecName: Full=Dual specificity protein phosphatase 15;          EC=3.1.3.48;          EC=3.1.3.16; AltName: Full=Vaccinia virus VH1-related dual-specific protein phosphatase Y; AltName: Full=VH1-related member Y;	269						cytoplasm|plasma membrane	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GGGTTGCCAGGGGTTGAGGAC	0.642			NA											15	19					0	0	0.003163	0	0
TM9SF4	9777	broad.mit.edu	37	20	30730905	30730905	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:30730905G>T	uc002wxj.2	+	6	884	c.649G>T	c.(649-651)GAG>TAG	p.E217*	TM9SF4_uc010ztr.1_Nonsense_Mutation_p.E143*|TM9SF4_uc010zts.1_Nonsense_Mutation_p.E124*|TM9SF4_uc002wxk.2_Nonsense_Mutation_p.E200*|TM9SF4_uc010gdz.2_Nonsense_Mutation_p.E124*	NM_014742	NP_055557	Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	217						integral to membrane				central_nervous_system(1)|pancreas(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CATCAGGCTGGAGGGTGAGTG	0.617			NA											11	44					3.07112e-06	3.69843e-06	0.010729	1	0
PLCG1	5335	broad.mit.edu	37	20	39792419	39792419	+	Missense_Mutation	SNP	C	C	G	rs150381500		TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:39792419C>G	uc002xjp.1	+	10	1077	c.956C>G	c.(955-957)CCG>CGG	p.P319R	PLCG1_uc002xjo.1_Missense_Mutation_p.P319R|PLCG1_uc010zwe.1_5'Flank|PLCG1_uc010ggf.2_5'Flank	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	319					activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				GCAGTATGCCCGGACACCATG	0.547			NA											18	85					0	0	0.006122	0	0
PTPRT	11122	broad.mit.edu	37	20	40748600	40748600	+	Silent	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:40748600T>A	uc002xkg.2	-	20	3043	c.2859A>T	c.(2857-2859)CGA>CGT	p.R953R	PTPRT_uc010ggj.2_Silent_p.R972R|PTPRT_uc010ggi.2_Silent_p.R156R	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	953	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				AGTGCCGAGGTCGATGGTATC	0.453			NA											38	86					0	0	0.011902	0	0
MMP9	4318	broad.mit.edu	37	20	44639949	44639949	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:44639949A>T	uc002xqz.2	+	5	836	c.817A>T	c.(817-819)AGC>TGC	p.S273C		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	273	Fibronectin type-II 1.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	CTTCTGCCCCAGCGAGAGTGA	0.532			NA											22	57					0	0	0.00278	0	0
SLC2A10	81031	broad.mit.edu	37	20	45354645	45354645	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:45354645G>T	uc002xsl.2	+	2	1067	c.970G>T	c.(970-972)GAC>TAC	p.D324Y		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	324	Extracellular (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CGTGCCCATGGACTCAGGCCC	0.652			NA											17	42					1.5739e-10	2.19568e-10	0.004007	1	0
ZNFX1	57169	broad.mit.edu	37	20	47886764	47886764	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:47886764C>T	uc002xui.2	-	3	1832	c.1585G>A	c.(1585-1587)GAT>AAT	p.D529N		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	529							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			AAGGGAACATCTTCCTCCTGG	0.512			NA											13	117					0	0	0.001855	0	0
ZNFX1	57169	broad.mit.edu	37	20	47886771	47886771	+	Silent	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:47886771C>T	uc002xui.2	-	3	1825	c.1578G>A	c.(1576-1578)CAG>CAA	p.Q526Q		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	526							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CATCTTCCTCCTGGACCTCCT	0.527			NA											12	107					0	0	0.013537	0	0
SALL4	57167	broad.mit.edu	37	20	50408856	50408856	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:50408856C>A	uc002xwh.3	-	2	267	c.166G>T	c.(166-168)GCG>TCG	p.A56S	SALL4_uc010gii.2_Missense_Mutation_p.A56S|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	56					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TCCTCACTCGCCACCTCGTCA	0.507			NA											23	61					2.98393e-07	3.78151e-07	0.00278	1	0
MC3R	4159	broad.mit.edu	37	20	54824480	54824480	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:54824480C>T	uc002xxb.2	+	1	693	c.581C>T	c.(580-582)ACC>ATC	p.T194I		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	231	Helical; Name=5; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			TGCCTCATCACCATGTTCTTC	0.582			NA											27	84					0	0	0.004656	0	0
MC3R	4159	broad.mit.edu	37	20	54824808	54824808	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:54824808C>A	uc002xxb.2	+	1	1021	c.909C>A	c.(907-909)AGC>AGA	p.S303R		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	340	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			CTTTCCGGAGCCTGGAATTGC	0.537			NA											49	143					3.50607e-19	5.78373e-19	0.01441	1	0
BMP7	655	broad.mit.edu	37	20	55758937	55758937	+	Silent	SNP	G	G	T	rs148287752		TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:55758937G>T	uc010gip.1	-	4	1328	c.799C>A	c.(799-801)CGG>AGG	p.R267R	BMP7_uc010giq.1_Intron|BMP7_uc002xyc.2_Silent_p.R267R	NM_001719	NP_001710	P18075	BMP7_HUMAN	bone morphogenetic protein 7 precursor	267					BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity			skin(1)	1	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)			GGCCCGTGCCGCCCAATCAGG	0.627			NA											9	26					7.48243e-07	9.29137e-07	0.006214	1	0
ZNF831	128611	broad.mit.edu	37	20	57829644	57829644	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:57829644T>C	uc002yan.2	+	5	4880	c.4880T>C	c.(4879-4881)GTG>GCG	p.V1627A		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1627						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					AAAGATTCTGTGGTTCCTTCT	0.488			NA											31	62					0	0	0.009535	0	0
CHRNA4	1137	broad.mit.edu	37	20	61981902	61981902	+	Silent	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:61981902G>C	uc002yes.2	-	5	1039	c.861C>G	c.(859-861)GTC>GTG	p.V287V	CHRNA4_uc002yet.1_Silent_p.V111V|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Silent_p.V216V|CHRNA4_uc002yev.1_Silent_p.V111V|CHRNA4_uc010gkf.1_Silent_p.V111V	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	287	Helical; (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	GCAGCAGGAAGACGGTGAGCG	0.592			NA											15	51					0	0	0.003163	0	0
CHRNA4	1137	broad.mit.edu	37	20	61982063	61982063	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:61982063T>C	uc002yes.2	-	5	878	c.700A>G	c.(700-702)ACC>GCC	p.T234A	CHRNA4_uc002yet.1_Missense_Mutation_p.T58A|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Missense_Mutation_p.T163A|CHRNA4_uc002yev.1_Missense_Mutation_p.T58A|CHRNA4_uc010gkf.1_Missense_Mutation_p.T58A	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	234	Extracellular (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	AAGGCATAGGTGATGTCCGGG	0.592			NA											24	50					0	0	0.00632	0	0
TPTE	7179	broad.mit.edu	37	21	10910328	10910328	+	Silent	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr21:10910328C>G	uc002yip.1	-	22	1796	c.1428G>C	c.(1426-1428)GTG>GTC	p.V476V	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Silent_p.V458V|TPTE_uc002yir.1_Silent_p.V438V|TPTE_uc010gkv.1_Silent_p.V338V	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	476	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACTGCACTTTCACATCATCAT	0.343			NA											17	104					0	0	0.008871	0	0
KRTAP19-2	337969	broad.mit.edu	37	21	31859528	31859528	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr21:31859528C>A	uc011acy.1	-	1	140	c.140G>T	c.(139-141)AGA>ATA	p.R47I		NM_181608	NP_853639	Q3LHN2	KR192_HUMAN	keratin associated protein 19-2	47						intermediate filament					0						GCCAGTGAATCTATATCTTCT	0.398			NA											40	100					4.07013e-28	7.28113e-28	0.00874	1	0
KRTAP19-3	337970	broad.mit.edu	37	21	31864067	31864067	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr21:31864067G>A	uc002yog.1	-	1	209	c.209C>T	c.(208-210)TCA>TTA	p.S70L		NM_181609	NP_853640	Q7Z4W3	KR193_HUMAN	keratin associated protein 19-3	70						intermediate filament					0						TCCATAGTATGATGGGCGGTA	0.483			NA											96	130					0	0	0.01441	0	0
KRTAP11-1	337880	broad.mit.edu	37	21	32253560	32253560	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr21:32253560G>T	uc002yov.2	-	1	315	c.284C>A	c.(283-285)CCC>CAC	p.P95H		NM_175858	NP_787054	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	95						keratin filament	structural molecule activity			pancreas(1)	1						AGTTGAGCAGGGGTTGGAAAT	0.572			NA											10	58					0.00621372	0.00664495	0.006214	1	0
PCNT	5116	broad.mit.edu	37	21	47783764	47783764	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr21:47783764G>T	uc002zji.3	+	14	2631	c.2524G>T	c.(2524-2526)GAG>TAG	p.E842*	PCNT_uc002zjj.2_Nonsense_Mutation_p.E724*	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	842					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GTGTGGGCGGGAGCCGCCCAC	0.662			NA											15	142					4.75885e-15	7.4515e-15	0.00499	1	0
GAB4	128954	broad.mit.edu	37	22	17447089	17447089	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr22:17447089C>A	uc002zlw.2	-	6	1297	c.1189G>T	c.(1189-1191)GGC>TGC	p.G397C	GAB4_uc010gqs.1_3'UTR	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member	397										large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				AGTGGGGAGCCAAGCAGGTCA	0.602			NA											12	53					3.07112e-06	3.69843e-06	0.010729	1	0
SCARF2	91179	broad.mit.edu	37	22	20781790	20781790	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr22:20781790G>A	uc002zsj.1	-	10	1708	c.1603C>T	c.(1603-1605)CCA>TCA	p.P535S	SCARF2_uc002zsk.1_Missense_Mutation_p.P530S	NM_153334	NP_699165	Q96GP6	SREC2_HUMAN	scavenger receptor class F, member 2 isoform 1	530	Cytoplasmic (Potential).				cell adhesion	integral to membrane	protein binding|receptor activity			breast(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CCTGAGGGTGGCTCCAGGAAG	0.627			NA											17	138					0	0	0.00499	0	0
PIWIL3	440822	broad.mit.edu	37	22	25115791	25115791	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr22:25115791T>C	uc003abd.1	-	20	2873	c.2456A>G	c.(2455-2457)TAT>TGT	p.Y819C	PIWIL3_uc011ajx.1_Missense_Mutation_p.Y701C|PIWIL3_uc011ajy.1_Missense_Mutation_p.Y701C|PIWIL3_uc010gut.1_Missense_Mutation_p.Y810C	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	819	Piwi.				cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						AATCGTGTCATAGATGACGTT	0.383			NA											5	68					0	0	0.001984	0	0
NCRNA00207	388910	broad.mit.edu	37	22	44967363	44967363	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr22:44967363G>A	uc003bev.1	+	3	300	c.233G>A	c.(232-234)AGG>AAG	p.R78K	NCRNA00207_uc011aqg.1_RNA|NCRNA00207_uc011aqh.1_RNA	NM_001012986	NP_001013004			SubName: Full=Novel gene;												0						CAGCAGAGCAGGCTGGACTGG	0.458			NA											5	29					0	0	0.000602	0	0
PLXNB2	23654	broad.mit.edu	37	22	50724601	50724601	+	Splice_Site	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr22:50724601C>T	uc003bkv.3	-	9	1983	c.1877_splice	c.e9+1	p.P626_splice		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor						regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AAGACACTCACGGCAGGTTCT	0.627			NA											10	86					0	0	0.008291	0	0
ZNF445	353274	broad.mit.edu	37	3	44496980	44496980	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:44496980C>A	uc003cnf.2	-	3	410	c.62G>T	c.(61-63)GGG>GTG	p.G21V	ZNF445_uc011azv.1_Missense_Mutation_p.G21V|ZNF445_uc011azw.1_Missense_Mutation_p.G21V	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	21					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		CTGAAGCCGCCCTCGCTCCCT	0.577			NA											35	34					2.09667e-21	3.50997e-21	0.003755	1	0
ZDHHC3	51304	broad.mit.edu	37	3	44986781	44986781	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:44986781C>T	uc003cod.2	-	3	584	c.310G>A	c.(310-312)GCA>ACA	p.A104T	ZDHHC3_uc003cog.2_Missense_Mutation_p.A104T|ZDHHC3_uc011bad.1_Missense_Mutation_p.A104T	NM_016598	NP_057682	Q9NYG2	ZDHC3_HUMAN	zinc finger, DHHC-type containing 3 isoform 2	104	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00943)|KIRC - Kidney renal clear cell carcinoma(197;0.053)|Kidney(197;0.0665)		TTGGGCACTGCCCCCTGTAGG	0.488			NA											5	152					0	0	0.000602	0	0
DALRD3	55152	broad.mit.edu	37	3	49055934	49055934	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:49055934C>G	uc003cvk.1	-	1	84	c.64G>C	c.(64-66)GGC>CGC	p.G22R	DALRD3_uc003cvl.1_Missense_Mutation_p.G22R|DALRD3_uc003cvm.1_Intron|DALRD3_uc010hko.1_5'UTR|DALRD3_uc011bca.1_Missense_Mutation_p.G22R|NDUFAF3_uc003cvn.2_5'Flank|NDUFAF3_uc003cvp.2_5'Flank	NM_001009996	NP_001009996	Q5D0E6	DALD3_HUMAN	DALR anticodon binding domain containing 3	22					arginyl-tRNA aminoacylation	cytoplasm	arginine-tRNA ligase activity|ATP binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ACCGGACCGCCTGGCCCCAGG	0.682			NA											3	6					0	0	0.004672	0	0
IQCF3	401067	broad.mit.edu	37	3	51864584	51864584	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:51864584C>A	uc010hlx.1	+	5	573	c.232C>A	c.(232-234)CGG>AGG	p.R78R	IQCF1_uc003dbq.3_Intron|IQCF3_uc010hlw.1_RNA|IQCF3_uc011bdw.1_RNA	NM_001085479	NP_001078948	P0C7M6	IQCF3_HUMAN	IQ motif containing F3	78										ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GATCCGTCAGCGGCGGCAGGC	0.647			NA											38	36					2.04263e-09	2.76981e-09	0.004289	1	0
RRP9	9136	broad.mit.edu	37	3	51968721	51968721	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:51968721C>G	uc003dbw.1	-	12	1145	c.1106G>C	c.(1105-1107)GGA>GCA	p.G369A		NM_004704	NP_004695	O43818	U3IP2_HUMAN	RNA, U3 small nucleolar interacting protein 2	369					rRNA processing	nucleolus|small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex	RNA binding			breast(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;8.04e-05)|Kidney(197;0.000553)|KIRC - Kidney renal clear cell carcinoma(197;0.000724)		GCCTGGCTCTCCCCGCAGCCC	0.617			NA											41	25					0	0	0.00874	0	0
NEK4	6787	broad.mit.edu	37	3	52802578	52802578	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:52802578C>A	uc003dfq.3	-	2	325	c.136G>T	c.(136-138)GAG>TAG	p.E46*	NEK4_uc011bej.1_Intron|NEK4_uc003dfr.2_Nonsense_Mutation_p.E46*	NM_003157	NP_003148	P51957	NEK4_HUMAN	NIMA-related kinase 4	46	Protein kinase.				cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		GCTCGCCGCTCTCGGCTAGAG	0.453			NA											77	75					8.70839e-23	1.48723e-22	0.01441	1	0
OR5H15	403274	broad.mit.edu	37	3	97888150	97888150	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:97888150T>A	uc011bgu.1	+	1	607	c.607T>A	c.(607-609)TCA>ACA	p.S203T		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	203	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTTTATTTTCTCAGGTTCAAT	0.313			NA											7	34					0	0	0.00308	0	0
ALCAM	214	broad.mit.edu	37	3	105266233	105266234	+	Splice_Site	DNP	GG	GG	TT			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:105266233_105266234GG>TT	uc003dvx.2	+	11	1781	c.1241_splice	c.e11-1	p.G414_splice	ALCAM_uc003dvw.1_Splice_Site_p.G414_splice|ALCAM_uc003dvy.2_Splice_Site_p.G414_splice|ALCAM_uc010hpp.2_Splice_Site_p.G136_splice|ALCAM_uc003dvz.2_Splice_Site_p.G48_splice	NM_001627	NP_001618	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule						cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(2)|breast(1)	3						TAATATTTCAGGCAAACCTCAA	0.322			NA											13	13					0	0	0.004672	0	0
ABHD10	55347	broad.mit.edu	37	3	111700675	111700675	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:111700675C>G	uc003dyk.3	+	2	268	c.187C>G	c.(187-189)CTT>GTT	p.L63V	ABHD10_uc011bhq.1_Intron	NM_018394	NP_060864	Q9NUJ1	ABHDA_HUMAN	abhydrolase domain containing 10 precursor	63						mitochondrion	serine-type peptidase activity				0						TCGACCAGACCTTCCAAACCT	0.378			NA											63	68					0	0	0.01441	0	0
DRD3	1814	broad.mit.edu	37	3	113866281	113866281	+	Silent	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:113866281C>G	uc003ebd.2	-	5	930	c.507G>C	c.(505-507)CTG>CTC	p.L169L	DRD3_uc010hqn.1_Silent_p.L169L|DRD3_uc003ebb.1_Silent_p.L169L|DRD3_uc003ebc.1_Silent_p.L169L	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	169	Helical; Name=4.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	TAAAGCCAAACAGAAGAGGGC	0.542			NA											50	63					0	0	0.01441	0	0
C3orf1	51300	broad.mit.edu	37	3	119236107	119236107	+	Nonsense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:119236107C>T	uc003ecn.2	+	6	865	c.652C>T	c.(652-654)CAG>TAG	p.Q218*	C3orf1_uc003eco.2_RNA|C3orf1_uc003ecp.2_RNA	NM_016589	NP_057673	Q9NPL8	TIDC1_HUMAN	hypothetical protein LOC51300	218						integral to membrane|mitochondrial inner membrane	protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.186)		TGAGACTGTTCAGGAAAGAAA	0.478			NA											81	58					0	0	0.01441	0	0
UROC1	131669	broad.mit.edu	37	3	126211293	126211293	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:126211293T>C	uc003eiz.1	-	16	1608	c.1576A>G	c.(1576-1578)ATT>GTT	p.I526V	UROC1_uc010hsi.1_Missense_Mutation_p.I586V	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	526					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		GCCTGGTTAATGGCCACAGCG	0.617			NA											11	8					0	0	0.008291	0	0
ZIC4	84107	broad.mit.edu	37	3	147114033	147114033	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:147114033G>T	uc003ewd.1	-	3	567	c.294C>A	c.(292-294)TAC>TAA	p.Y98*	ZIC4_uc003ewc.1_Nonsense_Mutation_p.Y28*|ZIC4_uc011bno.1_Nonsense_Mutation_p.Y148*	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	98						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						TCATGCCCCCGTAGCCATGCA	0.687			NA											20	17					3.51602e-12	5.05055e-12	0.008871	1	0
C3orf55	152078	broad.mit.edu	37	3	157271098	157271098	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:157271098A>T	uc003fbp.3	+	2	220	c.52A>T	c.(52-54)ACG>TCG	p.T18S	C3orf55_uc011bos.1_RNA|C3orf55_uc003fbo.2_Missense_Mutation_p.T18S|C3orf55_uc011bot.1_RNA|C3orf55_uc010hvv.2_Missense_Mutation_p.T18S	NM_001130002	NP_001123474	A1A4F0	CC055_HUMAN	hypothetical protein LOC152078 isoform 1	18											0			Lung(72;0.0215)|LUSC - Lung squamous cell carcinoma(72;0.037)			AAGCACTGATACGTCCGGAGA	0.289			NA											15	3					0	0	0.008871	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906575	164906575	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:164906575G>T	uc003fej.3	-	2	2488	c.2044C>A	c.(2044-2046)CGT>AGT	p.R682S	SLITRK3_uc003fek.2_Missense_Mutation_p.R682S	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	682	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						TTCTTTCGACGCCTTCGGAGC	0.502			NA								HNSCC(40;0.11)			24	22					1.17739e-12	1.72413e-12	0.005443	1	0
NLGN1	22871	broad.mit.edu	37	3	173322580	173322580	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:173322580G>T	uc003fio.1	+	3	615	c.192G>T	c.(190-192)GGG>GGT	p.G64G	NLGN1_uc010hww.1_Silent_p.G64G|NLGN1_uc003fip.1_Silent_p.G64G	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	64	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			AGATAAGAGGGATTAAGAAGG	0.453			NA											91	68					5.66823e-36	1.03031e-35	0.01441	1	0
NAALADL2	254827	broad.mit.edu	37	3	175520882	175520882	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:175520882A>T	uc003fit.2	+	14	2366	c.2279A>T	c.(2278-2280)GAG>GTG	p.E760V		NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	760	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		GCATCAAATGAGACCCTTCAA	0.433			NA											26	24					0	0	0.003954	0	0
RTP2	344892	broad.mit.edu	37	3	187416656	187416656	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:187416656C>A	uc003fro.1	-	2	737	c.308G>T	c.(307-309)CGG>CTG	p.R103L		NM_001004312	NP_001004312	Q5QGT7	RTP2_HUMAN	receptor transporting protein 2	103	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding				0	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		CTCGTCCAGCCGCGCCGTGCC	0.652			NA											14	7					3.27435e-08	4.26925e-08	0.00245	1	0
LSG1	55341	broad.mit.edu	37	3	194366963	194366963	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:194366963C>A	uc003fui.2	-	12	1868	c.1553G>T	c.(1552-1554)GGA>GTA	p.G518V		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	518					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		TGTCATGAATCCTCGCATGTC	0.453			NA											18	126					1.67942e-08	2.21526e-08	0.006122	1	0
SDHAP2	727956	broad.mit.edu	37	3	195400795	195400795	+	Missense_Mutation	SNP	C	C	T	rs7615357	by1000genomes	TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:195400795C>T	uc003fuw.2	+	9	1285	c.91C>T	c.(91-93)CGC>TGC	p.R31C	SDHAP2_uc011btb.1_Missense_Mutation_p.S178L|SDHAP2_uc011btc.1_RNA|SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						GGGGCAAACTCGCTGTTGGAC	0.592			NA											4	9					0	0	0.000602	0	0
SDHAP2	727956	broad.mit.edu	37	3	195400822	195400822	+	Missense_Mutation	SNP	G	G	A	rs56170658	by1000genomes	TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr3:195400822G>A	uc003fuw.2	+	9	1312	c.118G>A	c.(118-120)GCA>ACA	p.A40T	SDHAP2_uc011btb.1_Missense_Mutation_p.G187D|SDHAP2_uc011btc.1_RNA|SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						GTCTGGTCAGGCATGTGCCCT	0.567			NA											3	9					0	0	0.000602	0	0
FAM193A	8603	broad.mit.edu	37	4	2698298	2698298	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:2698298G>A	uc010icl.2	+	16	2963	c.2612G>A	c.(2611-2613)CGA>CAA	p.R871Q	FAM193A_uc010ick.2_Missense_Mutation_p.R1071Q|FAM193A_uc003gfd.2_Missense_Mutation_p.R871Q|FAM193A_uc011bvm.1_Missense_Mutation_p.R893Q|FAM193A_uc011bvn.1_Missense_Mutation_p.R871Q|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Missense_Mutation_p.R725Q	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	871										ovary(3)	3						GCAGCGAAGCGAGCAAGGCAT	0.552			NA											4	30					0	0	0.009096	0	0
STK32B	55351	broad.mit.edu	37	4	5170126	5170126	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:5170126G>T	uc003gih.1	+	3	273	c.209G>T	c.(208-210)CGG>CTG	p.R70L	STK32B_uc010ida.1_Missense_Mutation_p.R23L	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	70	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						AATGTTTTCCGGGAGCTGCAG	0.537			NA											10	31					1.08611e-07	1.39466e-07	0.010729	1	0
EVC	2121	broad.mit.edu	37	4	5750028	5750028	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:5750028G>T	uc003gil.1	+	8	1277	c.1093G>T	c.(1093-1095)GCT>TCT	p.A365S	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Missense_Mutation_p.P459T	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	365					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				GGAGCTGCAGGCTCTGGTAAT	0.478			NA											12	32					0.000151284	0.000171237	0.001855	1	0
ZNF518B	85460	broad.mit.edu	37	4	10445318	10445318	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:10445318G>C	uc003gmn.2	-	3	3122	c.2635C>G	c.(2635-2637)CTG>GTG	p.L879V		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	879					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						CTGGAAAGCAGTCTCCCTTGC	0.393			NA											10	85					0	0	0.006214	0	0
CLNK	116449	broad.mit.edu	37	4	10566338	10566338	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:10566338G>C	uc003gmo.3	-	7	493	c.356C>G	c.(355-357)TCC>TGC	p.S119C	CLNK_uc003gmp.2_Missense_Mutation_p.S77C	NM_052964	NP_443196	Q7Z7G1	CLNK_HUMAN	mast cell immunoreceptor signal transducer	119					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			ovary(1)	1						CTGTCCAATGGAGATAGAGGT	0.453	GBM(87;402 1286 6949 13902 35851)		NA											6	21					0	0	0.001168	0	0
ARAP2	116984	broad.mit.edu	37	4	36149351	36149351	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:36149351A>T	uc003gsq.1	-	18	3356	c.3018T>A	c.(3016-3018)TTT>TTA	p.F1006L		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1006					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AGTTTTCAGCAAATAAGGGAA	0.373			NA											13	20					0	0	0.001855	0	0
N4BP2	55728	broad.mit.edu	37	4	40115128	40115128	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:40115128G>T	uc003guy.3	+	7	2002	c.1664G>T	c.(1663-1665)AGG>ATG	p.R555M	N4BP2_uc010ifq.2_Missense_Mutation_p.R475M|N4BP2_uc010ifr.2_Missense_Mutation_p.R475M	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	555						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						GAACTTGCAAGGTAAAACTTG	0.363			NA											63	134					2.92391e-54	5.43126e-54	0.01441	1	0
GABRG1	2565	broad.mit.edu	37	4	46099303	46099303	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:46099303G>T	uc003gxb.2	-	2	320	c.168C>A	c.(166-168)GCC>GCA	p.A56A		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	56	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		GAATTTTTGGGGCCAAGACCC	0.368			NA											60	155					7.55815e-43	1.3963e-42	0.01441	1	0
PDGFRA	5156	broad.mit.edu	37	4	55131107	55131107	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:55131107A>T	uc003han.3	+	5	981	c.650A>T	c.(649-651)GAA>GTA	p.E217V	PDGFRA_uc003haa.2_Intron|PDGFRA_uc003hal.2_3'UTR|PDGFRA_uc010igq.1_Missense_Mutation_p.E111V|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	217	Ig-like C2-type 3.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CTGGATCTAGAAATGGAAGCT	0.383	Pancreas(151;208 1913 7310 23853 37092)		NA	Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			5	67					0	0	0.000602	0	0
UGT2B28	54490	broad.mit.edu	37	4	70146539	70146540	+	Missense_Mutation	DNP	AT	AT	TC			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	AT	AT	-	-	AT	AT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:70146539_70146540AT>TC	uc003hej.2	+	1	323_324	c.321_322AT>TC	c.(319-324)TTATAT>TTTCAT	p.107_108LY>FH	UGT2B28_uc010ihr.2_Missense_Mutation_p.107_108LY>FH	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	107_108					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	GCTTTTGGTTATATTTTTCACA	0.292			NA											37	123					0	0	0.004672	0	0
UGT2B4	7363	broad.mit.edu	37	4	70352326	70352326	+	Splice_Site	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:70352326C>G	uc003hek.3	-	4	1137	c.1090_splice	c.e4+1	p.G364_splice	UGT2B4_uc011cap.1_Splice_Site_p.G228_splice|UGT2B4_uc003hel.3_Splice_Site_p.D364_splice	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor						estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						CAGAGACTTACCAAGAAGATC	0.338			NA											13	96					0	0	0.013537	0	0
PLAC8	51316	broad.mit.edu	37	4	84028990	84028990	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:84028990C>T	uc003hoe.2	-	2	246	c.85G>A	c.(85-87)GGC>AGC	p.G29S	PLAC8_uc011cco.1_Missense_Mutation_p.G29S|PLAC8_uc010ijy.2_Intron|PLAC8_uc010ijz.2_Intron|PLAC8_uc003hod.2_Missense_Mutation_p.G29S	NM_001130716	NP_001124188	Q9NZF1	PLAC8_HUMAN	placenta-specific 8	29										ovary(1)	1		Hepatocellular(203;0.114)				TCACACATGCCTGTCTGCCAG	0.562			NA											10	38					0	0	0.008291	0	0
IBSP	3381	broad.mit.edu	37	4	88731895	88731895	+	Silent	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:88731895T>A	uc003hqx.3	+	6	482	c.384T>A	c.(382-384)GCT>GCA	p.A128A		NM_004967	NP_004958	P21815	SIAL_HUMAN	integrin-binding sialoprotein precursor	128	Asp/Glu-rich (acidic).				biomineral tissue development|cell adhesion|ossification						0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000333)|COAD - Colon adenocarcinoma(81;0.154)		CAGGGTTAGCTGCAATCCAGC	0.398			NA											21	68					0	0	0.008871	0	0
TBCK	93627	broad.mit.edu	37	4	107156448	107156448	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:107156448C>A	uc010ilv.2	-	15	1792	c.1427G>T	c.(1426-1428)TGG>TTG	p.W476L	TBCK_uc003hyb.2_Missense_Mutation_p.W219L|TBCK_uc003hye.2_Missense_Mutation_p.W437L|TBCK_uc003hyc.2_Missense_Mutation_p.W413L|TBCK_uc003hyd.2_Missense_Mutation_p.W304L|TBCK_uc003hyf.2_Missense_Mutation_p.W476L	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	476	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						AAGAGCAGCCCAGGTTAAACC	0.358			NA											11	28					0.00316338	0.00342069	0.003163	1	0
PITX2	5308	broad.mit.edu	37	4	111539486	111539486	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:111539486C>T	uc003iad.2	-	5	1331	c.749G>A	c.(748-750)AGC>AAC	p.S250N	PITX2_uc003iac.2_Missense_Mutation_p.S257N|PITX2_uc003iae.2_Missense_Mutation_p.S204N|PITX2_uc010iml.2_Missense_Mutation_p.S121N|PITX2_uc003iaf.2_Missense_Mutation_p.S250N	NM_153426	NP_700475	Q99697	PITX2_HUMAN	paired-like homeodomain transcription factor 2	250					determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription factor binding				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		CAGCGACGGGCTACTCAGGTT	0.597			NA											19	30					0	0	0.006122	0	0
FAT4	79633	broad.mit.edu	37	4	126336245	126336245	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:126336245G>T	uc003ifj.3	+	5	6127	c.6127G>T	c.(6127-6129)GAT>TAT	p.D2043Y	FAT4_uc011cgp.1_Missense_Mutation_p.D341Y	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2043	Cadherin 19.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TATTTTGTTGGATGTAAATGA	0.403			NA											41	139					2.26627e-22	3.83176e-22	0.007835	1	0
ARHGAP10	79658	broad.mit.edu	37	4	148744109	148744109	+	Splice_Site	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:148744109G>T	uc003ilf.2	+	3	312	c.312_splice	c.e3+1	p.M104_splice	ARHGAP10_uc003ile.1_Splice_Site_p.M104_splice	NM_024605	NP_078881	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10						apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			skin(2)|pancreas(1)|lung(1)	4	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		AGAAATTATGGTGAGTTGAGA	0.383			NA											15	36					1.37285e-15	2.16968e-15	0.004007	1	0
ACCN5	51802	broad.mit.edu	37	4	156787352	156787352	+	Silent	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:156787352T>C	uc003ipe.1	-	1	74	c.27A>G	c.(25-27)GTA>GTG	p.V9V		NM_017419	NP_059115	Q9NY37	ACCN5_HUMAN	amiloride-sensitive cation channel 5,	9	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0464)|Kidney(143;0.058)|COAD - Colon adenocarcinoma(41;0.141)		TCTCAGCATATACTTTTGATT	0.353			NA											35	90					0	0	0.004289	0	0
GRIA2	2891	broad.mit.edu	37	4	158262431	158262431	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:158262431C>A	uc003ipm.3	+	12	2319	c.1860C>A	c.(1858-1860)CGC>CGA	p.R620R	GRIA2_uc011cit.1_Silent_p.R573R|GRIA2_uc003ipl.3_Silent_p.R620R|GRIA2_uc003ipk.3_Silent_p.R573R|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	620	Cytoplasmic (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	TCTCTGGGCGCATTGTTGGAG	0.408			NA											25	142					6.32553e-13	9.34359e-13	0.004656	1	0
GK3P	2713	broad.mit.edu	37	4	166200358	166200358	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:166200358G>T	uc003ird.3	-	1	818	c.440C>A	c.(439-441)ACT>AAT	p.T147N	KLHL2_uc003irb.2_Intron|KLHL2_uc011cjm.1_Intron|KLHL2_uc003irc.2_Intron|KLHL2_uc010ira.2_Intron	NM_000167	NP_000158			glycerol kinase isoform b												0						ACTGAAGTAAGTGCTAAGTGG	0.413			NA											23	94					3.08376e-08	4.0285e-08	0.00333	1	0
NEK1	4750	broad.mit.edu	37	4	170345816	170345816	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:170345816G>A	uc003isb.1	-	29	3518	c.3026C>T	c.(3025-3027)CCA>CTA	p.P1009L	NEK1_uc003isc.1_Missense_Mutation_p.P965L|NEK1_uc003isd.1_Missense_Mutation_p.P1037L|NEK1_uc003ise.1_Missense_Mutation_p.P993L|NEK1_uc003isf.1_Missense_Mutation_p.P940L	NM_012224	NP_036356	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	1009					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		GGATTCTTCTGGTGAACACTG	0.393			NA											22	60					0	0	0.00333	0	0
ENPP6	133121	broad.mit.edu	37	4	185045347	185045347	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:185045347G>A	uc003iwc.2	-	3	642	c.500C>T	c.(499-501)GCC>GTC	p.A167V		NM_153343	NP_699174	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	167	Extracellular (Potential).				lipid catabolic process	extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)	1		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		GACTGCATTGGCAAAATTGAT	0.443			NA											4	230					0	0	0.000602	0	0
ACSL1	2180	broad.mit.edu	37	4	185679038	185679038	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:185679038T>C	uc003iww.2	-	19	2113	c.1819A>G	c.(1819-1821)ACA>GCA	p.T607A	ACSL1_uc011ckm.1_Missense_Mutation_p.T436A|ACSL1_uc003iwt.1_Missense_Mutation_p.T607A|ACSL1_uc003iwu.1_Missense_Mutation_p.T607A|ACSL1_uc011ckn.1_Missense_Mutation_p.T573A|ACSL1_uc003iws.1_Missense_Mutation_p.T167A	NM_001995	NP_001986	P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	607	Cytoplasmic (Potential).				digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			ovary(2)	2		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GAACATAATGTCTCAACATCT	0.383			NA											10	95					0	0	0.008291	0	0
FAM149A	25854	broad.mit.edu	37	4	187077278	187077278	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:187077278G>A	uc003iyt.3	+	7	1087	c.508G>A	c.(508-510)GTC>ATC	p.V170I	FAM149A_uc011cla.1_Missense_Mutation_p.V170I|FAM149A_uc010isj.2_Missense_Mutation_p.V170I|FAM149A_uc010isk.2_RNA|FAM149A_uc003iyu.3_Missense_Mutation_p.V170I|FAM149A_uc010isl.2_Missense_Mutation_p.V170I|FAM149A_uc011clb.1_Missense_Mutation_p.V170I	NM_015398	NP_056213	A5PLN7	F149A_HUMAN	hypothetical protein LOC25854	461										breast(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		GTTTGATCACGTCTGGACAAA	0.463			NA											17	62					0	0	0.004007	0	0
TUBB4Q	56604	broad.mit.edu	37	4	190905449	190905449	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:190905449G>T	uc011clg.1	-	3	238	c.235C>A	c.(235-237)CCC>ACC	p.P79T		NM_020040	NP_064424	Q99867	TBB4Q_HUMAN	tubulin, beta polypeptide 4, member Q	80					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;4.1e-31)|Epithelial(3;1.44e-30)|OV - Ovarian serous cystadenocarcinoma(60;2.03e-15)|BRCA - Breast invasive adenocarcinoma(30;8.54e-06)|Lung(3;3.23e-05)|STAD - Stomach adenocarcinoma(60;8.24e-05)|LUSC - Lung squamous cell carcinoma(40;0.000184)|GBM - Glioblastoma multiforme(59;0.00839)|READ - Rectum adenocarcinoma(43;0.155)		TGCCCGAAGGGCCCCGAGCGC	0.667			NA											17	62					1.96895e-08	2.58711e-08	0.00278	1	0
AHRR	57491	broad.mit.edu	37	5	434671	434671	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr5:434671A>T	uc003jav.2	+	12	1926	c.1882A>T	c.(1882-1884)AGG>TGG	p.R628W	AHRR_uc003jaw.2_Missense_Mutation_p.R606W|AHRR_uc010isy.2_Missense_Mutation_p.R456W|AHRR_uc010isz.2_Missense_Mutation_p.R606W|AHRR_uc003jax.2_Missense_Mutation_p.R369W|AHRR_uc003jay.2_Missense_Mutation_p.R466W|AHRR_uc003jaz.2_Missense_Mutation_p.R227W	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	610	Needed for transcriptional repression (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			TGGGCGCAGCAGGGAGCTGAC	0.687			NA											5	15					0	0	0.000602	0	0
CDH12	1010	broad.mit.edu	37	5	21783506	21783506	+	Missense_Mutation	SNP	T	T	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr5:21783506T>G	uc010iuc.2	-	8	1812	c.1354A>C	c.(1354-1356)ACT>CCT	p.T452P	CDH12_uc011cno.1_Missense_Mutation_p.T412P|CDH12_uc003jgk.2_Missense_Mutation_p.T452P	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	452	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						TACTGCGCAGTGCTTTCTCTG	0.378			NA								HNSCC(59;0.17)			22	130					0	0	0.00278	0	0
SPEF2	79925	broad.mit.edu	37	5	35779385	35779385	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr5:35779385G>T	uc003jjo.2	+	30	4495	c.4384G>T	c.(4384-4386)GGT>TGT	p.G1462C	SPEF2_uc003jjp.1_Missense_Mutation_p.G948C|SPEF2_uc003jjr.2_5'UTR	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1462					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGAAGAAGATGGTACCCTGAC	0.383			NA											13	72					7.93312e-07	9.79719e-07	0.00245	1	0
IL7R	3575	broad.mit.edu	37	5	35876570	35876570	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr5:35876570C>A	uc003jjs.2	+	8	1451	c.1362C>A	c.(1360-1362)AGC>AGA	p.S454R	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	454	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			CCATGTCCAGCTTCTACCAAA	0.453			NA											7	21					0.00198382	0.00216243	0.001984	1	0
C7	730	broad.mit.edu	37	5	40945338	40945338	+	Silent	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr5:40945338T>C	uc003jmh.2	+	7	720	c.606T>C	c.(604-606)AAT>AAC	p.N202N	C7_uc011cpn.1_Intron	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	202	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				AATTTTACAATAGTACTTGGT	0.303			NA											6	9					0	0	0.001168	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64587298	64587298	+	Splice_Site	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr5:64587298C>A	uc003jtp.2	-	11	2185	c.1371_splice	c.e11-1	p.D457_splice	ADAMTS6_uc003jto.2_Splice_Site|ADAMTS6_uc003jtq.2_Splice_Site|ADAMTS6_uc003jtr.1_Splice_Site_p.D78_splice	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1						proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		ACGGCCTGAACTGTTCAACAT	0.423			NA											14	28					0.000151284	0.000171237	0.001855	1	0
RAD17	5884	broad.mit.edu	37	5	68670537	68670537	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr5:68670537A>T	uc003jwo.2	+	3	445	c.383A>T	c.(382-384)CAG>CTG	p.Q128L	RAD17_uc003jwg.2_Missense_Mutation_p.Q117L|RAD17_uc003jwh.2_Missense_Mutation_p.Q117L|RAD17_uc003jwi.2_Missense_Mutation_p.Q117L|RAD17_uc003jwj.2_Missense_Mutation_p.Q117L|RAD17_uc003jwk.2_Missense_Mutation_p.Q117L|RAD17_uc003jwl.2_Missense_Mutation_p.Q117L|RAD17_uc003jwm.2_5'UTR|RAD17_uc003jwn.2_Missense_Mutation_p.Q31L	NM_133339	NP_579917	O75943	RAD17_HUMAN	RAD17 homolog isoform 2	128					cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		CAACCAAAACAGGTAACTAAG	0.279			NA						Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					20	25					0	0	0.008871	0	0
ANKRD34B	340120	broad.mit.edu	37	5	79855837	79855837	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr5:79855837A>G	uc010jam.2	-	4	352	c.2T>C	c.(1-3)ATG>ACG	p.M1T	ANKRD34B_uc003kgw.2_Missense_Mutation_p.M1T|ANKRD34B_uc010jan.2_Missense_Mutation_p.M1T	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	1						cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		ACCTTCATCCATCTTCGGAGG	0.423			NA											7	13					0	0	0.001984	0	0
TMEM161B	153396	broad.mit.edu	37	5	87502892	87502892	+	Silent	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr5:87502892T>A	uc003kjc.2	-	6	677	c.552A>T	c.(550-552)GCA>GCT	p.A184A	TMEM161B_uc011cty.1_Silent_p.A173A|TMEM161B_uc010jax.2_RNA|TMEM161B_uc011ctz.1_Silent_p.A51A|TMEM161B_uc011ctx.1_Silent_p.A2A	NM_153354	NP_699185	Q8NDZ6	T161B_HUMAN	transmembrane protein 161B	184	Helical; (Potential).					integral to membrane				skin(2)	2		all_cancers(142;0.000275)|Lung NSC(167;0.00901)|all_lung(232;0.0111)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;6.24e-36)|Epithelial(54;6.8e-31)|all cancers(79;1.07e-26)		CAATCAACACTGCCATTGCTT	0.289			NA											9	23					0	0	0.010729	0	0
FBN2	2201	broad.mit.edu	37	5	127700347	127700347	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr5:127700347G>T	uc003kuu.2	-	18	2813	c.2374C>A	c.(2374-2376)CGT>AGT	p.R792S	FBN2_uc003kuv.2_Missense_Mutation_p.R759S	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	792	EGF-like 11; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CAATTACAACGGTAACTACCA	0.333			NA											11	20					3.86212e-05	4.4457e-05	0.008291	1	0
SLC26A2	1836	broad.mit.edu	37	5	149357616	149357616	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr5:149357616G>T	uc003lrh.2	+	2	669	c.401G>T	c.(400-402)GGC>GTC	p.G134V		NM_000112	NP_000103	P50443	S26A2_HUMAN	solute carrier family 26 member 2	134	Extracellular (Potential).					integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CTGCTGGCTGGCCAAGAACCT	0.438			NA											35	54					1.56738e-10	2.19568e-10	0.004289	1	0
FAM114A2	10827	broad.mit.edu	37	5	153390880	153390880	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr5:153390880C>A	uc003lvb.2	-	9	1502	c.914G>T	c.(913-915)GGG>GTG	p.G305V	FAM114A2_uc003lvc.2_Missense_Mutation_p.G305V|FAM114A2_uc003lvd.2_Missense_Mutation_p.G305V|FAM114A2_uc003lve.2_Missense_Mutation_p.G121V|FAM114A2_uc011dda.1_Missense_Mutation_p.G235V	NM_018691	NP_061161	Q9NRY5	F1142_HUMAN	hypothetical protein LOC10827	305							purine nucleotide binding				0						ATCTTCATCCCCTAAAAAACC	0.428			NA											20	19					2.94398e-08	3.85332e-08	0.007413	1	0
BTNL8	79908	broad.mit.edu	37	5	180338550	180338550	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr5:180338550C>A	uc003mmp.2	+	3	843	c.609C>A	c.(607-609)AGC>AGA	p.S203R	BTNL8_uc003mmq.2_Missense_Mutation_p.S203R|BTNL8_uc011dhg.1_Missense_Mutation_p.S78R|BTNL8_uc010jll.2_Missense_Mutation_p.S203R|BTNL8_uc010jlm.2_Missense_Mutation_p.S87R|BTNL8_uc011dhh.1_Missense_Mutation_p.S19R	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor	203	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACGCCGGGAGCATATCCTGTT	0.547			NA											26	47					4.87955e-14	7.43447e-14	0.005443	1	0
DUSP22	56940	broad.mit.edu	37	6	348120	348120	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:348120G>T	uc003msx.2	+	6	720	c.281G>T	c.(280-282)AGG>ATG	p.R94M	DUSP22_uc011dhn.1_Missense_Mutation_p.R94M|DUSP22_uc003msy.1_Missense_Mutation_p.R51M	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	94	Tyrosine-protein phosphatase.				apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		GGGGTCTCCAGGAGCGTGACA	0.617			NA											13	157					9.05144e-12	1.28387e-11	0.001855	1	0
SLC17A4	10050	broad.mit.edu	37	6	25777157	25777157	+	Missense_Mutation	SNP	C	C	G	rs142556117		TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:25777157C>G	uc003nfe.2	+	10	1357	c.1238C>G	c.(1237-1239)GCC>GGC	p.A413G	SLC17A4_uc011djx.1_Missense_Mutation_p.A183G|SLC17A4_uc003nff.1_Missense_Mutation_p.A202G|SLC17A4_uc003nfg.2_Missense_Mutation_p.A350G|SLC17A4_uc010jqa.2_Intron	NM_005495	NP_005486	Q9Y2C5	S17A4_HUMAN	solute carrier family 17 (sodium phosphate),	413	Helical; (Potential).				phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			skin(1)	1						GAATCAGGAGCCCTTGTTAAC	0.502			NA											36	105					0	0	0.004289	0	0
SLC17A4	10050	broad.mit.edu	37	6	25777188	25777188	+	Splice_Site	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:25777188G>T	uc003nfe.2	+	10	1387	c.1268_splice	c.e10+1	p.R423_splice	SLC17A4_uc011djx.1_Splice_Site_p.R193_splice|SLC17A4_uc003nff.1_Silent_p.R212R|SLC17A4_uc003nfg.2_Splice_Site_p.R360_splice|SLC17A4_uc010jqa.2_Intron	NM_005495	NP_005486	Q9Y2C5	S17A4_HUMAN	solute carrier family 17 (sodium phosphate),						phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			skin(1)	1						TTGCTCCTCGGTAGGGACCTC	0.473			NA											23	86					1.85244e-09	2.51694e-09	0.00333	1	0
SLC17A1	6568	broad.mit.edu	37	6	25813412	25813412	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:25813412A>T	uc003nfh.3	-	7	762	c.646T>A	c.(646-648)TGG>AGG	p.W216R	SLC17A1_uc011djy.1_Intron|SLC17A1_uc010jqb.1_Missense_Mutation_p.W214R|SLC17A1_uc010jqc.1_Missense_Mutation_p.W214R	NM_005074	NP_005065	Q14916	NPT1_HUMAN	solute carrier family 17 (sodium phosphate),	216	Helical; (Potential).				sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(3)|pancreas(1)	4						AGAACGAACCAGAGAAGACAT	0.448			NA											21	64					0	0	0.010504	0	0
HIST1H4B	8366	broad.mit.edu	37	6	26027319	26027319	+	Missense_Mutation	SNP	C	C	G	rs147907725		TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:26027319C>G	uc003nfr.2	-	1	162	c.162G>C	c.(160-162)GAG>GAC	p.E54D		NM_003544	NP_003535	P62805	H4_HUMAN	histone cluster 1, H4b	54					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						CGCCACGAGTCTCCTCATAAA	0.562			NA									OREG0017238	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	78					0	0	0.004672	0	0
BTN3A1	11119	broad.mit.edu	37	6	26413835	26413835	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:26413835T>C	uc003nhv.2	+	10	1825	c.1457T>C	c.(1456-1458)CTG>CCG	p.L486P	BTN3A1_uc011dkj.1_3'UTR|BTN3A1_uc011dkk.1_Missense_Mutation_p.L434P|BTN3A1_uc010jqj.2_3'UTR	NM_007048	NP_008979	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1 isoform a	486	Cytoplasmic (Potential).|B30.2/SPRY.				lipid metabolic process	integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						CATACTTTCCTGGACGTCTCC	0.468			NA											34	131					0	0	0.004289	0	0
HIST1H2AH	85235	broad.mit.edu	37	6	27115267	27115267	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:27115267G>A	uc003niz.2	+	1	360	c.360G>A	c.(358-360)AAG>AAA	p.K120K	HIST1H2BK_uc003nix.1_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080596	NP_542163	Q96KK5	H2A1H_HUMAN	histone cluster 1, H2ah	120					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TGCCTAAGAAGACTGAGAGCC	0.522			NA											15	67					0	0	0.003163	0	0
OR2J2	26707	broad.mit.edu	37	6	29142112	29142112	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:29142112G>T	uc011dlm.1	+	1	802	c.700G>T	c.(700-702)GGG>TGG	p.G234W		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATCAACCACTGGGCTTCAGAA	0.453			NA											33	108					5.20006e-24	8.99398e-24	0.011902	1	0
MDC1	9656	broad.mit.edu	37	6	30675788	30675788	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:30675788T>A	uc003nrg.3	-	8	3008	c.2568A>T	c.(2566-2568)AAA>AAT	p.K856N	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Intron	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	856				Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						CTCTGTCCTGTTTCCCCTTGG	0.468			NA						Other_conserved_DNA_damage_response_genes					110	284					0	0	0.01441	0	0
BAT3	7917	broad.mit.edu	37	6	31616977	31616977	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:31616977G>T	uc003nvg.3	-	4	736	c.422C>A	c.(421-423)CCT>CAT	p.P141H	BAT3_uc003nvf.3_Missense_Mutation_p.P141H|BAT3_uc003nvh.3_Missense_Mutation_p.P141H|BAT3_uc003nvi.3_Missense_Mutation_p.P141H|BAT3_uc011dnw.1_Missense_Mutation_p.P141H|BAT3_uc011dnx.1_Missense_Mutation_p.P141H|BAT3_uc003nvj.1_Missense_Mutation_p.P141H	NM_004639	NP_004630	P46379	BAG6_HUMAN	HLA-B associated transcript-3 isoform a	141					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding				0						TAAGCTTACAGGAAGATTGAA	0.512			NA											6	151					8.12818e-05	9.26203e-05	0.001984	1	0
MDGA1	266727	broad.mit.edu	37	6	37623622	37623622	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:37623622C>T	uc003onu.1	-	4	1612	c.433G>A	c.(433-435)GGC>AGC	p.G145S		NM_153487	NP_705691	Q8NFP4	MDGA1_HUMAN	MAM domain containing	145	Ig-like 2.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)	2						TAGAAGTTGCCTCGCACATCG	0.602			NA											12	20					0	0	0.003163	0	0
SLC22A7	10864	broad.mit.edu	37	6	43267478	43267478	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:43267478G>T	uc003out.2	+	4	716	c.617G>T	c.(616-618)GGC>GTC	p.G206V	SLC22A7_uc010jyl.1_Missense_Mutation_p.G204V|SLC22A7_uc003ous.2_Missense_Mutation_p.G204V	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	206	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			ACCCTTACTGGCTCAGCCCTG	0.577			NA											25	44					1.1804e-14	1.82719e-14	0.003954	1	0
OPN5	221391	broad.mit.edu	37	6	47754282	47754282	+	Silent	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:47754282C>T	uc003ozc.2	+	2	167	c.162C>T	c.(160-162)GTC>GTT	p.V54V	OPN5_uc003ozd.2_5'Flank	NM_181744	NP_859528	Q6U736	OPN5_HUMAN	opsin 5 isoform 1	54	Helical; Name=1; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1						ATGGATATGTCCTTTACATGT	0.368	Melanoma(28;740 973 10870 42660 45347)		NA											24	66					0	0	0.00333	0	0
C6orf138	442213	broad.mit.edu	37	6	47846147	47846147	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:47846147G>A	uc011dwm.1	-	3	2467	c.2382C>T	c.(2380-2382)CCC>CCT	p.P794P	C6orf138_uc011dwn.1_Silent_p.P558P	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	811						integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						TTTTGGAAGGGGGGAAAAACG	0.453			NA											37	77					0	0	0.003755	0	0
PGK2	5232	broad.mit.edu	37	6	49754640	49754640	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:49754640G>A	uc003ozu.2	-	1	368	c.261C>T	c.(259-261)TCC>TCT	p.S87S		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	87					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					TGCCCAGCAAGGATTTGAGCT	0.517			NA											36	109					0	0	0.003271	0	0
TINAG	27283	broad.mit.edu	37	6	54219385	54219385	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:54219385G>T	uc003pcj.2	+	9	1347	c.1201G>T	c.(1201-1203)GAA>TAA	p.E401*	TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	401					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			CACAAATAAAGAATCAGAAAA	0.323			NA											15	57					1.3612e-06	1.66588e-06	0.003163	1	0
GFRAL	389400	broad.mit.edu	37	6	55216299	55216299	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:55216299A>T	uc003pcm.1	+	5	705	c.619A>T	c.(619-621)AGC>TGC	p.S207C		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	207	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AGCTCTTCACAGCAAGACATG	0.423			NA											30	97					0	0	0.008361	0	0
DST	667	broad.mit.edu	37	6	56328453	56328453	+	Silent	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:56328453T>A	uc003pdf.2	-	94	16468	c.16440A>T	c.(16438-16440)TCA>TCT	p.S5480S	DST_uc003pcz.3_Silent_p.S5302S|DST_uc011dxj.1_Silent_p.S5331S|DST_uc011dxk.1_Silent_p.S5342S|DST_uc003pcy.3_Silent_p.S4976S|DST_uc003pcv.3_Silent_p.S98S|DST_uc003pcw.3_Silent_p.S59S|DST_uc003pcx.3_Silent_p.S59S	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	7412					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AAGCGCCTCGTGATGATGGCC	0.592			NA											32	82					0	0	0.012213	0	0
DST	667	broad.mit.edu	37	6	56371508	56371508	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:56371508C>A	uc003pdf.2	-	70	12990	c.12962G>T	c.(12961-12963)TGT>TTT	p.C4321F	DST_uc003pcz.3_Missense_Mutation_p.C4143F|DST_uc011dxj.1_Missense_Mutation_p.C4172F|DST_uc011dxk.1_Missense_Mutation_p.C4183F|DST_uc003pcy.3_Missense_Mutation_p.C3817F	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	6229	Spectrin 13.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AGGCTCCCCACATGCCGCAAT	0.373			NA											34	73					8.4185e-14	1.27976e-13	0.012213	1	0
C6orf221	154288	broad.mit.edu	37	6	74072525	74072525	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:74072525G>C	uc003pgt.3	+	1	126	c.73G>C	c.(73-75)GGT>CGT	p.G25R		NM_001017361	NP_001017361	Q587J8	ECAT1_HUMAN	hypothetical protein LOC154288	25										skin(2)	2						GGAGGTGCTCGGTCACCTCCC	0.577			NA											23	48					0	0	0.014323	0	0
COL12A1	1303	broad.mit.edu	37	6	75875291	75875291	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:75875291C>A	uc003phs.2	-	14	3081	c.2915G>T	c.(2914-2916)AGA>ATA	p.R972I	COL12A1_uc003pht.2_Intron	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	972	Fibronectin type-III 6.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						TACTGAAATTCTGTATTTGGT	0.408			NA											44	119					1.23713e-20	2.05582e-20	0.01441	1	0
BCKDHB	594	broad.mit.edu	37	6	80878601	80878601	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:80878601G>A	uc003pjd.2	+	5	554	c.487G>A	c.(487-489)GAA>AAA	p.E163K	BCKDHB_uc003pje.2_Missense_Mutation_p.E163K	NM_000056	NP_000047	P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1 beta	163					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding				0		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		GATTGTTAATGAAGCTGCCAA	0.418			NA											12	62					0	0	0.013537	0	0
DOPEY1	23033	broad.mit.edu	37	6	83829489	83829489	+	Silent	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:83829489C>T	uc003pjs.1	+	9	1163	c.903C>T	c.(901-903)ATC>ATT	p.I301I	DOPEY1_uc011dyy.1_Intron|DOPEY1_uc010kbl.1_Intron	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	301					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		ACGGTGCTATCATAGGACCCA	0.338			NA											9	94					0	0	0.010729	0	0
MDN1	23195	broad.mit.edu	37	6	90499592	90499592	+	Silent	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:90499592T>A	uc003pnn.1	-	7	1253	c.1137A>T	c.(1135-1137)GGA>GGT	p.G379G	MDN1_uc003pnp.1_Silent_p.G379G	NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	379					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		ACACAAACTCTCCAGGAACAT	0.488			NA											16	64					0	0	0.003163	0	0
SIM1	6492	broad.mit.edu	37	6	100838294	100838294	+	Missense_Mutation	SNP	T	T	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:100838294T>G	uc003pqj.3	-	11	2451	c.2244A>C	c.(2242-2244)CAA>CAC	p.Q748H	SIM1_uc010kcu.2_Missense_Mutation_p.Q748H	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	748	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		CTGGGTCTGGTTGCATCCTCA	0.413			NA											41	80					0	0	0.010771	0	0
SIM1	6492	broad.mit.edu	37	6	100838543	100838543	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:100838543G>T	uc003pqj.3	-	11	2202	c.1995C>A	c.(1993-1995)CGC>CGA	p.R665R	SIM1_uc010kcu.2_Silent_p.R665R	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	665	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		ATTTTGAAATGCGATCCGAAT	0.453			NA											71	173					3.25985e-27	5.78581e-27	0.01441	1	0
GRIK2	2898	broad.mit.edu	37	6	102074265	102074265	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:102074265G>T	uc003pqp.3	+	3	543	c.294G>T	c.(292-294)CAG>CAT	p.Q98H	GRIK2_uc003pqn.2_Missense_Mutation_p.Q98H|GRIK2_uc003pqo.3_Missense_Mutation_p.Q98H|GRIK2_uc010kcw.2_Missense_Mutation_p.Q98H	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	98	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	CCTGTGATCAGCTGTCTCTTG	0.488			NA											106	250					3.29639e-60	6.15689e-60	0.01441	1	0
AIM1	202	broad.mit.edu	37	6	106968029	106968029	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:106968029A>T	uc003prh.2	+	2	2209	c.1722A>T	c.(1720-1722)AGA>AGT	p.R574S		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	574							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		CTGAAGTTAGAGAAGTGCAGT	0.542			NA											20	42					0	0	0.007413	0	0
LAMA4	3910	broad.mit.edu	37	6	112460960	112460960	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:112460960C>T	uc003pvu.2	-	23	3413	c.3104G>A	c.(3103-3105)TGT>TAT	p.C1035Y	LAMA4_uc003pvv.2_Missense_Mutation_p.C1028Y|LAMA4_uc003pvt.2_Missense_Mutation_p.C1028Y	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1035	Laminin G-like 1.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TTACCGGGCACATGGCACTGA	0.408			NA											22	85					0	0	0.014323	0	0
ROS1	6098	broad.mit.edu	37	6	117686772	117686772	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:117686772T>A	uc003pxp.1	-	19	3144	c.2945A>T	c.(2944-2946)TAC>TTC	p.Y982F	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	982	Fibronectin type-III 4.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TTCTACACTGTAGAAAACTAC	0.428			NA	T	GOPC|ROS1	glioblastoma|NSCLC								13	39					0	0	0.001855	0	0
EYA4	2070	broad.mit.edu	37	6	133849873	133849873	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:133849873C>A	uc003qec.3	+	20	2308	c.1850C>A	c.(1849-1851)CCC>CAC	p.P617H	EYA4_uc011ecq.1_Missense_Mutation_p.P563H|EYA4_uc011ecr.1_Intron|EYA4_uc003qed.3_Missense_Mutation_p.P617H|EYA4_uc003qee.3_Missense_Mutation_p.P594H|EYA4_uc011ecs.1_Missense_Mutation_p.P623H|uc003qeg.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	617					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		CACAACATGCCCTTCTGGAGG	0.343	Melanoma(57;398 1237 3528 4702 7415)		NA											49	185					2.81731e-22	4.75158e-22	0.01441	1	0
BCLAF1	9774	broad.mit.edu	37	6	136599694	136599694	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:136599694G>T	uc003qgx.1	-	4	578	c.325C>A	c.(325-327)CGT>AGT	p.R109S	BCLAF1_uc003qgw.1_Missense_Mutation_p.R109S|BCLAF1_uc003qgy.1_Missense_Mutation_p.R107S|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.R107S	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	109					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GAACGTGAACGACCTCGTCTA	0.468	Colon(142;1534 1789 5427 7063 28491)		NA											49	209					6.81593e-30	1.22578e-29	0.01441	1	0
BCLAF1	9774	broad.mit.edu	37	6	136599790	136599790	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:136599790C>A	uc003qgx.1	-	4	482	c.229G>T	c.(229-231)GGT>TGT	p.G77C	BCLAF1_uc003qgw.1_Missense_Mutation_p.G77C|BCLAF1_uc003qgy.1_Missense_Mutation_p.G75C|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.G75C	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	77					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TACCCTCTACCCCTTCCTCTG	0.448	Colon(142;1534 1789 5427 7063 28491)		NA											15	130					7.41877e-09	9.96025e-09	0.012319	1	0
TXLNB	167838	broad.mit.edu	37	6	139564044	139564044	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:139564044G>T	uc011eds.1	-	10	1839	c.1674C>A	c.(1672-1674)CCC>CCA	p.P558P		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	558						cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		GAGGAGTTAGGGGAGGCAGGG	0.592			NA											27	49					1.66031e-10	2.30202e-10	0.003954	1	0
EPM2A	7957	broad.mit.edu	37	6	145948691	145948691	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:145948691C>T	uc003qkw.2	-	4	1214	c.857G>A	c.(856-858)GGC>GAC	p.G286D	EPM2A_uc003qkv.2_Missense_Mutation_p.G286D|EPM2A_uc010khr.2_Silent_p.G205G|EPM2A_uc003qkx.2_Missense_Mutation_p.G148D|EPM2A_uc003qku.2_Missense_Mutation_p.G132D	NM_005670	NP_005661	O95278	EPM2A_HUMAN	laforin isoform a	286	Tyrosine-protein phosphatase.				glycogen metabolic process	cytosol|endoplasmic reticulum|nucleus|plasma membrane|polysome	carbohydrate binding|identical protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Ovarian(120;0.162)		OV - Ovarian serous cystadenocarcinoma(155;3.38e-07)|GBM - Glioblastoma multiforme(68;0.0203)		CAGATTCCAGCCCATCACATA	0.592			NA											12	50					0	0	0.013537	0	0
SASH1	23328	broad.mit.edu	37	6	148761494	148761494	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:148761494G>T	uc003qme.1	+	4	812	c.337G>T	c.(337-339)GAG>TAG	p.E113*		NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	113							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		TCTCTCGTAGGAGTCGCTTGG	0.463			NA											25	77					5.77227e-19	9.49903e-19	0.008361	1	0
SASH1	23328	broad.mit.edu	37	6	148840928	148840928	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:148840928G>T	uc003qme.1	+	10	1583	c.1108G>T	c.(1108-1110)GGG>TGG	p.G370W	SASH1_uc011eeb.1_Missense_Mutation_p.G131W	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	370							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		CAAGAAGATGGGGACATTCTT	0.592			NA											20	26					1.00905e-13	1.52708e-13	0.008871	1	0
SYNE1	23345	broad.mit.edu	37	6	152542080	152542080	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:152542080G>A	uc010kiw.2	-	119	22360	c.21758C>T	c.(21757-21759)TCG>TTG	p.S7253L	SYNE1_uc010kiv.2_Missense_Mutation_p.S1777L|SYNE1_uc003qos.3_Missense_Mutation_p.S1777L|SYNE1_uc003qot.3_Missense_Mutation_p.S7182L|SYNE1_uc003qou.3_Missense_Mutation_p.S7253L|SYNE1_uc003qor.3_Missense_Mutation_p.S153L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7253	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGAACTGTCGAAGCACACTG	0.488			NA								HNSCC(10;0.0054)			10	176					0	0	0.006214	0	0
SYNE1	23345	broad.mit.edu	37	6	152623136	152623136	+	Silent	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:152623136C>T	uc010kiw.2	-	92	18011	c.17409G>A	c.(17407-17409)AAG>AAA	p.K5803K	SYNE1_uc010kiv.2_Silent_p.K327K|SYNE1_uc003qos.3_Silent_p.K327K|SYNE1_uc003qot.3_Silent_p.K5732K|SYNE1_uc003qou.3_Silent_p.K5803K|SYNE1_uc010kiy.1_Silent_p.K25K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5803	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCGTCAGCATCTTGCACTTGG	0.587			NA								HNSCC(10;0.0054)			44	84					0	0	0.01441	0	0
SYNE1	23345	broad.mit.edu	37	6	152658015	152658015	+	Silent	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:152658015C>T	uc010kiw.2	-	76	13091	c.12489G>A	c.(12487-12489)CTG>CTA	p.L4163L	SYNE1_uc003qot.3_Silent_p.L4092L|SYNE1_uc003qou.3_Silent_p.L4163L|SYNE1_uc010kja.1_Silent_p.L868L|SYNE1_uc010kiz.2_5'Flank	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4163	Spectrin 11.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGTTCAGCTCCAGCTCAGAGT	0.468			NA								HNSCC(10;0.0054)			31	93					0	0	0.003755	0	0
NOX3	50508	broad.mit.edu	37	6	155764448	155764448	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:155764448G>T	uc003qqm.2	-	5	548	c.445C>A	c.(445-447)CCT>ACT	p.P149T		NM_015718	NP_056533	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	149	Ferric oxidoreductase.|Extracellular (Potential).						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		CTCTCGTTAGGGGTGTTGCCC	0.572			NA											17	34					5.35267e-07	6.69577e-07	0.007413	1	0
LPA	4018	broad.mit.edu	37	6	161015063	161015063	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:161015063C>A	uc003qtl.2	-	23	3676	c.3556G>T	c.(3556-3558)GGA>TGA	p.G1186*		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3694	Kringle 33.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	CATGTCCTTCCTGTGACAGTG	0.473			NA											32	96					3.11337e-16	4.96675e-16	0.013726	1	0
SDK1	221935	broad.mit.edu	37	7	4169723	4169723	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:4169723G>A	uc003smx.2	+	27	4262	c.4123G>A	c.(4123-4125)GAC>AAC	p.D1375N	SDK1_uc010kso.2_Missense_Mutation_p.D651N|SDK1_uc003smy.2_5'UTR	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1375					cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GCGCACCAAAGACGATGGTAG	0.587			NA											6	36					0	0	0.001168	0	0
RADIL	55698	broad.mit.edu	37	7	4917441	4917441	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:4917441G>T	uc003snj.1	-	2	503	c.330C>A	c.(328-330)TAC>TAA	p.Y110*	RADIL_uc003sng.1_RNA|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	110	Ras-associating.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CACACAGCACGTACTGGCCGG	0.682			NA											33	47					3.99451e-17	6.43296e-17	0.009535	1	0
ETV1	2115	broad.mit.edu	37	7	13935690	13935690	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:13935690T>C	uc011jxq.1	-	14	1974	c.1235A>G	c.(1234-1236)TAC>TGC	p.Y412C	ETV1_uc011jxn.1_Missense_Mutation_p.Y372C|ETV1_uc011jxo.1_Missense_Mutation_p.Y309C|ETV1_uc011jxp.1_Missense_Mutation_p.Y354C|ETV1_uc003ssw.3_Missense_Mutation_p.Y389C|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Missense_Mutation_p.Y394C|ETV1_uc011jxs.1_Missense_Mutation_p.Y394C	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	412	ETS.				transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						CACAAACTTGTAGACATATCT	0.478			NA	T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								7	18					0	0	0.00308	0	0
FERD3L	222894	broad.mit.edu	37	7	19184872	19184872	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:19184872G>T	uc003suo.1	-	1	173	c.114C>A	c.(112-114)TCC>TCA	p.S38S	uc003sun.1_RNA	NM_152898	NP_690862	Q96RJ6	FER3L_HUMAN	nephew of atonal 3	38					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			large_intestine(1)	1						GGTCCCCCAAGGAGACCCCGG	0.532			NA											14	35					2.48551e-13	3.70368e-13	0.00499	1	0
DNAH11	8701	broad.mit.edu	37	7	21646324	21646324	+	Silent	SNP	A	A	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:21646324A>C	uc003svc.2	+	20	3856	c.3825A>C	c.(3823-3825)GCA>GCC	p.A1275A		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1275	Potential.|Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GATTTAATGCAGAAAATCCAT	0.328			NA							Kartagener_syndrome				12	21					0	0	0.00245	0	0
HOXA1	3198	broad.mit.edu	37	7	27134888	27134888	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:27134888G>T	uc003sye.2	-	1	738	c.644C>A	c.(643-645)CCC>CAC	p.P215H	HOXA1_uc003syd.2_3'UTR|uc003syg.2_5'Flank	NM_005522	NP_005513	P49639	HXA1_HUMAN	homeobox A1 isoform a	215						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3						ACCTGTTTTGGGAGGGTTTCT	0.473			NA											22	39					1.96292e-10	2.71604e-10	0.010504	1	0
HOXA3	3200	broad.mit.edu	37	7	27147727	27147727	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:27147727G>T	uc011jzl.1	-	3	1339	c.1139C>A	c.(1138-1140)CCA>CAA	p.P380Q	HOXA3_uc011jzk.1_Missense_Mutation_p.P222Q|HOXA3_uc003syk.2_Missense_Mutation_p.P380Q	NM_030661	NP_109377	O43365	HXA3_HUMAN	homeobox A3 isoform a	380					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)	2						AAAGAGGGCTGGCCCGGAGTT	0.692	Esophageal Squamous(136;1368 1743 5685 7935 50360)		NA											9	17					0.000274275	0.000306357	0.004482	1	0
HOXA3	3200	broad.mit.edu	37	7	27148137	27148137	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:27148137G>T	uc011jzl.1	-	3	929	c.729C>A	c.(727-729)CGC>CGA	p.R243R	HOXA3_uc011jzk.1_Silent_p.R85R|HOXA3_uc003syk.2_Silent_p.R243R	NM_030661	NP_109377	O43365	HXA3_HUMAN	homeobox A3 isoform a	243	Homeobox.				angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)	2						TGTACTTCATGCGGCGATTCT	0.612	Esophageal Squamous(136;1368 1743 5685 7935 50360)		NA											27	87					2.44723e-14	3.76241e-14	0.004656	1	0
STARD3NL	83930	broad.mit.edu	37	7	38247244	38247244	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:38247244G>A	uc003tfr.2	+	2	287	c.139G>A	c.(139-141)GGC>AGC	p.G47S	STARD3NL_uc003tfs.2_Missense_Mutation_p.G47S|STARD3NL_uc003tft.2_Missense_Mutation_p.G47S	NM_032016	NP_114405	O95772	MENTO_HUMAN	MLN64 N-terminal homolog	47	Cytoplasmic (Potential).					integral to membrane|late endosome membrane				ovary(1)	1						GGAAAAGAAAGGCATATCTGA	0.443			NA											33	91					0	0	0.012213	0	0
ABCA13	154664	broad.mit.edu	37	7	48443428	48443428	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:48443428C>A	uc003toq.2	+	39	12047	c.12022C>A	c.(12022-12024)CCT>ACT	p.P4008T	ABCA13_uc010kys.1_Missense_Mutation_p.P1082T|ABCA13_uc003tos.1_Missense_Mutation_p.P834T|ABCA13_uc010kyt.1_RNA	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4008	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TGGGGTGGACCCTTGCTCCCG	0.567			NA											11	36					4.68919e-08	6.09056e-08	0.008291	1	0
POM121L12	285877	broad.mit.edu	37	7	53103916	53103916	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:53103916G>T	uc003tpz.2	+	1	568	c.552G>T	c.(550-552)CAG>CAT	p.Q184H		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	184											0						CGCTCAGCCAGTGCCCCAAGG	0.577			NA											28	31					1.13719e-10	1.59962e-10	0.008361	1	0
FKBP9L	360132	broad.mit.edu	37	7	55759105	55759105	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:55759105G>T	uc010kzl.2	-	3	277	c.177C>A	c.(175-177)CAC>CAA	p.H59Q	FKBP9L_uc003tqt.2_5'Flank|FKBP9L_uc011kcs.1_5'Flank	NR_003949				SubName: Full=cDNA, FLJ79189, highly similar to FK506-binding protein 9 (EC 5.2.1.8);												0						GGGGTTTGTAGTGGGAGGTGA	0.517			NA											29	118					1.75199e-13	2.6164e-13	0.007291	1	0
CALN1	83698	broad.mit.edu	37	7	71743772	71743772	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:71743772A>T	uc003twa.3	-	2	544	c.17T>A	c.(16-18)GTG>GAG	p.V6E	CALN1_uc003twb.3_Missense_Mutation_p.V48E|CALN1_uc003twc.3_Missense_Mutation_p.V6E	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	6	Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				GCCGGCGGTCACATGGTGGAA	0.507			NA											22	17					0	0	0.010504	0	0
PCLO	27445	broad.mit.edu	37	7	82538323	82538323	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:82538323T>C	uc003uhx.2	-	8	13596	c.13307A>G	c.(13306-13308)CAT>CGT	p.H4436R	PCLO_uc003uhv.2_Missense_Mutation_p.H4436R	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4367					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ACGACGCAGATGATAGGCTTT	0.463			NA											10	91					0	0	0.008291	0	0
SEMA3D	223117	broad.mit.edu	37	7	84636143	84636143	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:84636143C>A	uc003uic.2	-	16	1923	c.1883G>T	c.(1882-1884)AGG>ATG	p.R628M	SEMA3D_uc010led.2_Missense_Mutation_p.R628M|SEMA3D_uc003uib.2_Missense_Mutation_p.R267M	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	628	Ig-like C2-type.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						ATCCCCTGACCTCTGGATATA	0.378	Ovarian(63;442 1191 17318 29975 31528)		NA											132	156					2.32137e-38	4.23088e-38	0.01441	1	0
KIAA1324L	222223	broad.mit.edu	37	7	86544146	86544146	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:86544146C>A	uc011kha.1	-	13	1809	c.1624G>T	c.(1624-1626)GAA>TAA	p.E542*	KIAA1324L_uc003uif.1_Nonsense_Mutation_p.E302*|KIAA1324L_uc011kgz.1_Nonsense_Mutation_p.E428*|KIAA1324L_uc003uie.2_Nonsense_Mutation_p.E375*	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	542	Extracellular (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					CCCCACGATTCTACCACATTT	0.323			NA											7	58					0.00198382	0.00216243	0.001984	1	0
ZKSCAN5	23660	broad.mit.edu	37	7	99129089	99129089	+	Nonsense_Mutation	SNP	T	T	A	rs28411998		TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:99129089T>A	uc003uqv.2	+	7	1861	c.1737T>A	c.(1735-1737)TGT>TGA	p.C579*	ZKSCAN5_uc010lfx.2_Nonsense_Mutation_p.C579*|ZKSCAN5_uc003uqw.2_Nonsense_Mutation_p.C579*|ZKSCAN5_uc003uqx.2_Nonsense_Mutation_p.C506*|ZKSCAN5_uc003uqy.2_Nonsense_Mutation_p.C315*	NM_145102	NP_659570	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	579	C2H2-type 6.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CATTCAGGTGTGAGGAATGTG	0.473			NA											33	74					0	0	0.009535	0	0
EPHB4	2050	broad.mit.edu	37	7	100421830	100421830	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:100421830C>T	uc003uwn.1	-	2	609	c.118G>A	c.(118-120)GGG>AGG	p.G40R	EPHB4_uc003uwm.1_5'UTR|EPHB4_uc010lhj.1_Missense_Mutation_p.G40R|EPHB4_uc011kkf.1_Missense_Mutation_p.G40R|EPHB4_uc011kkg.1_Missense_Mutation_p.G40R|EPHB4_uc011kkh.1_Missense_Mutation_p.G40R	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	40	Extracellular (Potential).				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					CTCACCTGCCCGTCCACCTGA	0.592	GBM(200;2113 3072 25865 52728)		NA											10	339					0	0	0.013537	0	0
MUC17	140453	broad.mit.edu	37	7	100683533	100683533	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:100683533A>G	uc003uxp.1	+	3	8889	c.8836A>G	c.(8836-8838)AGC>GGC	p.S2946G	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2946	Extracellular (Potential).|47.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TTCTGAGGCTAGCACCCTTTC	0.493			NA											59	877					0	0	0.01441	0	0
ALKBH4	54784	broad.mit.edu	37	7	102097955	102097955	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:102097955G>A	uc003uzl.2	-	3	800	c.795C>T	c.(793-795)CGC>CGT	p.R265R	ALKBH4_uc003uzm.2_Silent_p.R192R	NM_017621	NP_060091	Q9NXW9	ALKB4_HUMAN	alkB, alkylation repair homolog 4	265						cytoplasm|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						TGACGCAGACGCGGCGGGCCT	0.682			NA											6	85					0	0	0.001168	0	0
CBLL1	79872	broad.mit.edu	37	7	107399544	107399544	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:107399544T>C	uc003veq.2	+	6	1727	c.1397T>C	c.(1396-1398)TTG>TCG	p.L466S	CBLL1_uc011kme.1_Missense_Mutation_p.L345S|CBLL1_uc011kmf.1_Missense_Mutation_p.L465S	NM_024814	NP_079090	Q75N03	HAKAI_HUMAN	Cas-Br-M (murine) ecotropic retroviral	466	Pro-rich.				cell-cell adhesion|negative regulation of cell adhesion|positive regulation of cell migration|positive regulation of endocytosis		protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|skin(2)|lung(1)	5						CCTCCACGATTGCAGGGTCCG	0.488			NA											95	247					0	0	0.01441	0	0
LAMB1	3912	broad.mit.edu	37	7	107596050	107596050	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:107596050G>T	uc003vew.2	-	21	3051	c.2716C>A	c.(2716-2718)CCC>ACC	p.P906T	LAMB1_uc003vev.2_Missense_Mutation_p.P930T	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	906	Laminin EGF-like 8.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCAATGATGGGGTCGCCATAG	0.537			NA											30	50					5.45727e-16	8.68551e-16	0.008361	1	0
NRCAM	4897	broad.mit.edu	37	7	107790398	107790398	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:107790398G>T	uc003vfb.2	-	33	4343	c.3872C>A	c.(3871-3873)TCA>TAA	p.S1291*	NRCAM_uc003vfc.2_Nonsense_Mutation_p.S1170*|NRCAM_uc011kmk.1_Nonsense_Mutation_p.S1193*|NRCAM_uc003vfd.2_Nonsense_Mutation_p.S1174*|NRCAM_uc003vfe.2_Nonsense_Mutation_p.S1162*|NRCAM_uc003vez.2_Nonsense_Mutation_p.S74*|NRCAM_uc003vfa.2_Nonsense_Mutation_p.S135*|NRCAM_uc011kmj.1_Nonsense_Mutation_p.S137*	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	1291	Cytoplasmic (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						AGGTGCCTCTGAGCTTTCGTT	0.413			NA											300	116					1.66838e-123	3.13342e-123	0.01441	1	0
DOCK4	9732	broad.mit.edu	37	7	111368565	111368565	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:111368565C>A	uc003vfx.2	-	52	5935	c.5666G>T	c.(5665-5667)GGG>GTG	p.G1889V	DOCK4_uc011kml.1_Missense_Mutation_p.G770V|DOCK4_uc011kmm.1_Missense_Mutation_p.G758V|DOCK4_uc003vfw.2_Missense_Mutation_p.G1301V|DOCK4_uc003vfy.2_Missense_Mutation_p.G1934V|DOCK4_uc003vfv.2_Missense_Mutation_p.G202V	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1889	Pro-rich.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				TGGCTCCTCCCCGCCGTAGCT	0.667			NA											22	184					6.33239e-15	9.84715e-15	0.010504	1	0
DOCK4	9732	broad.mit.edu	37	7	111580244	111580244	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:111580244G>C	uc003vfx.2	-	11	1167	c.898C>G	c.(898-900)CCC>GCC	p.P300A	DOCK4_uc003vfy.2_Missense_Mutation_p.P300A|DOCK4_uc003vga.1_5'UTR|DOCK4_uc010ljt.1_Missense_Mutation_p.P300A	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	300					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				CAGCCAAAGGGTCGTCGGTAC	0.448			NA											129	301					0	0	0.01441	0	0
NAA38	51691	broad.mit.edu	37	7	117828412	117828412	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:117828412G>T	uc003vjg.2	+	3	345	c.153G>T	c.(151-153)GGG>GGT	p.G51G		NM_016200	NP_057284	O95777	NAA38_HUMAN	U6 snRNA-associated Sm-like protein LSm8	51					nuclear mRNA splicing, via spliceosome	nucleus|ribonucleoprotein complex	protein binding|U6 snRNA binding				0						CTTCACAGGGGGTAGAACAAG	0.348			NA											56	50					1.00798e-23	1.73455e-23	0.01441	1	0
GPR37	2861	broad.mit.edu	37	7	124387384	124387384	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:124387384C>A	uc003vli.2	-	2	1688	c.1037G>T	c.(1036-1038)GGA>GTA	p.G346V		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	346	Helical; Name=3; (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						AGTGGTGACTCCCAGAGAAGC	0.468			NA											12	67					1.5739e-10	2.19568e-10	0.004007	1	0
PLXNA4	91584	broad.mit.edu	37	7	131913210	131913210	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:131913210C>A	uc003vra.3	-	6	1852	c.1623G>T	c.(1621-1623)CGG>CGT	p.R541R		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	541	PSI 1.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						ACCGCTCACACCGCTCCTTCC	0.597			NA											17	32					8.00594e-06	9.48956e-06	0.007413	1	0
ATP6V0A4	50617	broad.mit.edu	37	7	138455936	138455936	+	Silent	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:138455936C>G	uc003vuf.2	-	2	295	c.57G>C	c.(55-57)GTG>GTC	p.V19V	ATP6V0A4_uc003vug.2_Silent_p.V19V|ATP6V0A4_uc003vuh.2_Silent_p.V19V	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	19	Cytoplasmic (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						ATGCAGCTTCCACCTGGAGAA	0.478			NA											45	263					0	0	0.013114	0	0
Unknown	0	broad.mit.edu	37	7	142001010	142001010	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:142001010G>A	uc011kro.1	+	2	147	c.102G>A	c.(100-102)ATG>ATA	p.M34I						SubName: Full=V_segment translation product; Flags: Fragment;												NA						TCACACAGATGGGACAGGAAG	0.443			NA											25	21					0	0	0.00278	0	0
EPHB6	2051	broad.mit.edu	37	7	142566876	142566876	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:142566876G>T	uc011kst.1	+	16	3220	c.2433G>T	c.(2431-2433)GTG>GTT	p.V811V	EPHB6_uc011ksu.1_Silent_p.V811V|EPHB6_uc003wbs.2_Silent_p.V519V|EPHB6_uc003wbt.2_Silent_p.V285V|EPHB6_uc003wbu.2_Silent_p.V519V|EPHB6_uc003wbv.2_Silent_p.V195V	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	811	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					TGTGCAAGGTGGCCCGTCTTG	0.637			NA											41	22					2.00842e-17	3.27334e-17	0.010771	1	0
KEL	3792	broad.mit.edu	37	7	142658913	142658913	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:142658913G>T	uc003wcb.2	-	2	260	c.50C>A	c.(49-51)GCA>GAA	p.A17E		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	17	Cytoplasmic (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					CATTCCACCTGCCTGGCTGCG	0.547			NA											73	398					1.25089e-41	2.29838e-41	0.01441	1	0
KRBA1	84626	broad.mit.edu	37	7	149421940	149421940	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:149421940G>A	uc003wfz.2	+	9	1525	c.1126G>A	c.(1126-1128)GCT>ACT	p.A376T	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_Missense_Mutation_p.A44T	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	376										ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGAGGCTCAAGGTGAGGCCTG	0.642			NA											8	7					0	0	0.00308	0	0
GIMAP8	155038	broad.mit.edu	37	7	150163991	150163991	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:150163991C>A	uc003whj.2	+	2	535	c.205C>A	c.(205-207)CTT>ATT	p.L69I		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	69						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CACCCCTGACCTTTTCTCCTC	0.488			NA											15	237					1.49906e-05	1.74333e-05	0.00245	1	0
EFHA2	286097	broad.mit.edu	37	8	16956024	16956024	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:16956024C>G	uc003wxd.2	+	9	988	c.946C>G	c.(946-948)CGT>GGT	p.R316G		NM_181723	NP_859074	Q86XE3	EFHA2_HUMAN	EF-hand domain family, member A2	316						integral to membrane	calcium ion binding			skin(1)	1				Colorectal(111;0.0686)|COAD - Colon adenocarcinoma(73;0.239)		TACACTGAGACGTAACACAAG	0.388	Pancreas(177;1461 2846 10523 14242)|Colon(184;2703 2719 18484 23400)		NA											59	94					0	0	0.01441	0	0
ADAM2	2515	broad.mit.edu	37	8	39613420	39613420	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:39613420A>G	uc003xnj.2	-	16	1699	c.1624T>C	c.(1624-1626)TGC>CGC	p.C542R	ADAM2_uc003xnk.2_Missense_Mutation_p.C523R|ADAM2_uc011lck.1_Intron|ADAM2_uc003xnl.2_Intron	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	542	Extracellular (Potential).|Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		AATTTTCCGCACTGCAGATTG	0.239			NA											14	215					0	0	0.00245	0	0
ANK1	286	broad.mit.edu	37	8	41526069	41526069	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:41526069C>A	uc003xok.2	-	39	5194	c.5110G>T	c.(5110-5112)GAT>TAT	p.D1704Y	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.D858Y|ANK1_uc003xoi.2_Missense_Mutation_p.D1704Y|ANK1_uc003xoj.2_Missense_Mutation_p.D1704Y|ANK1_uc003xol.2_Missense_Mutation_p.D1542Y|ANK1_uc003xom.2_Missense_Mutation_p.D1745Y	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1704	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CCGTCTGCATCCCAGTCCTGC	0.547			NA											16	60					1.15088e-07	1.47225e-07	0.004007	1	0
PREX2	80243	broad.mit.edu	37	8	69046421	69046421	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:69046421G>T	uc003xxv.1	+	32	3921	c.3894G>T	c.(3892-3894)ATG>ATT	p.M1298I		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1298					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						AAAATGAGATGGAAACTTGGG	0.488			NA											33	67					5.91797e-21	9.85843e-21	0.012213	1	0
TRAM1	23471	broad.mit.edu	37	8	71495976	71495976	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:71495976G>A	uc003xyo.1	-	9	969	c.799C>T	c.(799-801)CTT>TTT	p.L267F	TRAM1_uc011lfc.1_Missense_Mutation_p.L236F	NM_014294	NP_055109	Q15629	TRAM1_HUMAN	translocation associated membrane protein 1	267	Helical; (Potential).|TLC.				cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			ovary(1)	1			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			AGTACTGAAAGAATTAAAGTC	0.388	Ovarian(85;984 1334 5116 12432 40638)		NA											46	104					0	0	0.01441	0	0
TCEB1	6921	broad.mit.edu	37	8	74868148	74868148	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:74868148G>T	uc003xzx.1	-	3	231	c.146C>A	c.(145-147)CCA>CAA	p.P49Q	TCEB1_uc003xzy.1_Missense_Mutation_p.P49Q|TCEB1_uc003xzz.1_Missense_Mutation_p.P33Q|TCEB1_uc003yaa.1_Missense_Mutation_p.P49Q	NM_005648	NP_005639	Q15369	ELOC_HUMAN	elongin C	49					interspecies interaction between organisms|positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|ubiquitin-dependent protein catabolic process|viral reproduction	cytosol|nucleoplasm	protein binding				0	Breast(64;0.0311)		Epithelial(68;0.0136)|all cancers(69;0.0431)|BRCA - Breast invasive adenocarcinoma(89;0.0499)			GTGCTTACCTGGGCCACTCAA	0.323			NA											26	56					1.75199e-13	2.6164e-13	0.007291	1	0
ZFHX4	79776	broad.mit.edu	37	8	77763493	77763493	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:77763493G>A	uc003yav.2	+	10	4588	c.4201G>A	c.(4201-4203)GCA>ACA	p.A1401T	ZFHX4_uc003yau.1_Missense_Mutation_p.A1446T|ZFHX4_uc003yaw.1_Missense_Mutation_p.A1401T	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1401	C2H2-type 11.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACACTTGGAAGCAGGCCACCC	0.493			NA								HNSCC(33;0.089)			16	28					0	0	0.004007	0	0
SLC26A7	115111	broad.mit.edu	37	8	92406044	92406044	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:92406044G>T	uc003yex.2	+	18	2074	c.1796G>T	c.(1795-1797)GGC>GTC	p.G599V	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Missense_Mutation_p.G599V|SLC26A7_uc003yfa.2_Missense_Mutation_p.G599V	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	599	STAS.|Cytoplasmic (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			GACTGTAAAGGCAGGAGTGTG	0.383			NA											38	94					2.66277e-13	3.95911e-13	0.006999	1	0
RBM12B	389677	broad.mit.edu	37	8	94747803	94747803	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:94747803C>A	uc003yfz.2	-	3	1029	c.836G>T	c.(835-837)CGT>CTT	p.R279L		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	279							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			AAGAGGGGAACGAGAACGTGT	0.368			NA											36	67					2.42023e-17	3.91627e-17	0.003271	1	0
VPS13B	157680	broad.mit.edu	37	8	100182372	100182372	+	Silent	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:100182372C>T	uc003yiv.2	+	16	2425	c.2314C>T	c.(2314-2316)CTG>TTG	p.L772L	VPS13B_uc003yiw.2_Silent_p.L772L|VPS13B_uc003yit.2_Silent_p.L772L|VPS13B_uc003yiu.1_Silent_p.L772L|VPS13B_uc003yix.1_Silent_p.L243L	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	772					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TGGGAAACTTCTGAAACTCCC	0.403	Colon(161;2205 2542 7338 31318)		NA											10	51					0	0	0.008291	0	0
RIMS2	9699	broad.mit.edu	37	8	105001577	105001577	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:105001577G>A	uc003yls.2	+	15	2547	c.2306G>A	c.(2305-2307)GGA>GAA	p.G769E	RIMS2_uc003ylp.2_Missense_Mutation_p.G991E|RIMS2_uc003ylw.2_Missense_Mutation_p.G783E|RIMS2_uc003ylq.2_Missense_Mutation_p.G783E|RIMS2_uc003ylr.2_Missense_Mutation_p.G830E	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1053					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ACTATGACCGGACATTATAAT	0.383			NA								HNSCC(12;0.0054)			23	72					0	0	0.00278	0	0
TRHR	7201	broad.mit.edu	37	8	110131489	110131489	+	Silent	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:110131489C>T	uc003ymz.3	+	2	1018	c.1002C>T	c.(1000-1002)CTC>CTT	p.L334L		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	334	Cytoplasmic (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			TCAGAAAGCTCTGCAACTGCA	0.453			NA											68	153					0	0	0.01441	0	0
CSMD3	114788	broad.mit.edu	37	8	113348921	113348921	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:113348921C>G	uc003ynu.2	-	44	7138	c.6979G>C	c.(6979-6981)GTC>CTC	p.V2327L	CSMD3_uc003yns.2_Missense_Mutation_p.V1529L|CSMD3_uc003ynt.2_Missense_Mutation_p.V2287L|CSMD3_uc011lhx.1_Missense_Mutation_p.V2223L|CSMD3_uc003ynw.1_Missense_Mutation_p.V38L	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2327	Extracellular (Potential).|CUB 13.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GTTTGAAGGACAGTAAAATTG	0.338			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			48	132					0	0	0.01441	0	0
CSMD3	114788	broad.mit.edu	37	8	113364763	113364763	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:113364763G>T	uc003ynu.2	-	39	6296	c.6137C>A	c.(6136-6138)GCA>GAA	p.A2046E	CSMD3_uc003yns.2_Missense_Mutation_p.A1248E|CSMD3_uc003ynt.2_Missense_Mutation_p.A2006E|CSMD3_uc011lhx.1_Missense_Mutation_p.A1942E	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2046	Extracellular (Potential).|CUB 11.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CAAACCAATTGCTAAGAATAT	0.318			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			48	79					8.30282e-39	1.51733e-38	0.01441	1	0
CSMD3	114788	broad.mit.edu	37	8	113484937	113484937	+	Splice_Site	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:113484937C>A	uc003ynu.2	-	32	5438	c.5279_splice	c.e32-1	p.A1760_splice	CSMD3_uc003yns.2_Splice_Site_p.A1032_splice|CSMD3_uc003ynt.2_Splice_Site_p.A1720_splice|CSMD3_uc011lhx.1_Splice_Site_p.A1656_splice	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1							integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCACAGGGCGCTAGGAAAAAA	0.313			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			21	43					1.87028e-06	2.28067e-06	0.012319	1	0
SNTB1	6641	broad.mit.edu	37	8	121706136	121706136	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:121706136C>G	uc010mdg.2	-	2	810	c.584G>C	c.(583-585)CGA>CCA	p.R195P	SNTB1_uc003ype.2_Missense_Mutation_p.R195P	NM_021021	NP_066301	Q13884	SNTB1_HUMAN	basic beta 1 syntrophin	195	PH 1.|PDZ.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			skin(5)	5	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			CGTGGCTTCTCGCATGTACTT	0.483			NA											49	65					0	0	0.01441	0	0
HAS2	3037	broad.mit.edu	37	8	122626567	122626567	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:122626567C>A	uc003yph.2	-	4	1979	c.1441G>T	c.(1441-1443)GTA>TTA	p.V481L		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	481	Helical; Name=6; (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			CAAACTGATACTGGAATGAGT	0.398			NA											41	89					5.73237e-09	7.74212e-09	0.00623	1	0
WISP1	8840	broad.mit.edu	37	8	134225219	134225219	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:134225219G>A	uc003yub.2	+	2	258	c.182G>A	c.(181-183)CGC>CAC	p.R61H	WISP1_uc003yuc.2_Missense_Mutation_p.R61H|WISP1_uc010meb.2_Intron|WISP1_uc010mec.2_Missense_Mutation_p.R61H|WISP1_uc010med.2_Intron|WISP1_uc003yud.2_5'Flank	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	61	IGFBP N-terminal.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			TCCCCACCCCGCTGCCCGCTG	0.627			NA											13	28					0	0	0.003163	0	0
GML	2765	broad.mit.edu	37	8	143928046	143928046	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:143928046G>T	uc003yxg.2	+	4	507	c.417G>T	c.(415-417)CTG>CTT	p.L139L		NM_002066	NP_002057	Q99445	GML_HUMAN	glycosylphosphatidylinositol anchored molecule	139					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell proliferation	anchored to membrane|extrinsic to membrane|plasma membrane				central_nervous_system(2)	2	all_cancers(97;4.26e-11)|all_epithelial(106;1.85e-08)|Lung NSC(106;0.000274)|all_lung(105;0.000755)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					CTGTGAGGCTGGGGGTATCAA	0.478			NA											37	55					1.60099e-16	2.56007e-16	0.004878	1	0
CYP11B1	1584	broad.mit.edu	37	8	143957731	143957731	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:143957731G>T	uc003yxi.2	-	5	887	c.880C>A	c.(880-882)CTG>ATG	p.L294M	CYP11B1_uc010mex.2_5'Flank|CYP11B1_uc003yxh.2_Translation_Start_Site|CYP11B1_uc003yxj.2_Missense_Mutation_p.L294M|CYP11B1_uc010mey.2_Missense_Mutation_p.L365M	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	294					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	GCATTCAACAGGAGCTCCGCC	0.597			NA							Familial_Hyperaldosteronism_type_I				15	27					0.00316338	0.00342069	0.003163	1	0
CPSF1	29894	broad.mit.edu	37	8	145622835	145622835	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:145622835G>A	uc003zcj.2	-	22	2327	c.2252C>T	c.(2251-2253)TCG>TTG	p.S751L		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	751					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			GAGGGAGCCCGAATCCCCATA	0.677	NSCLC(133;1088 1848 27708 34777 35269)		NA											17	75					0	0	0.00499	0	0
ZNF34	80778	broad.mit.edu	37	8	145998963	145998963	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr8:145998963G>C	uc003zdy.3	-	6	1473	c.1371C>G	c.(1369-1371)AGC>AGG	p.S457R	ZNF34_uc010mgb.2_Missense_Mutation_p.S354R|ZNF34_uc003zdx.3_Missense_Mutation_p.S436R	NM_030580	NP_085057	Q8IZ26	ZNF34_HUMAN	zinc finger protein 34	457	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.221)	OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;5.18e-38)|all cancers(56;4.41e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.0179)		GTGTGCTTTGGCTGAAAACTT	0.488			NA											15	45					0	0	0.004007	0	0
UNC13B	10497	broad.mit.edu	37	9	35376131	35376131	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr9:35376131A>G	uc003zwq.2	+	14	1767	c.1475A>G	c.(1474-1476)TAT>TGT	p.Y492C	UNC13B_uc003zwr.2_Missense_Mutation_p.Y492C	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	492	Phorbol-ester/DAG-type.				excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			ACCTACTGCTATGAGTGTGAA	0.547			NA											41	60					0	0	0.011902	0	0
GRIN3A	116443	broad.mit.edu	37	9	104432627	104432627	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr9:104432627G>A	uc004bbp.1	-	3	2668	c.2067C>T	c.(2065-2067)GCC>GCT	p.A689A	GRIN3A_uc004bbq.1_Silent_p.A689A	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	689	Helical; (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TGAGGAAGACGGCAGTGATGT	0.493			NA											63	64					0	0	0.01441	0	0
OR13F1	138805	broad.mit.edu	37	9	107266855	107266855	+	Silent	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr9:107266855C>T	uc011lvm.1	+	1	312	c.312C>T	c.(310-312)TCC>TCT	p.S104S		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	104	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						TGTACCTCTCCCTTGCCATGG	0.517			NA											24	52					0	0	0.014323	0	0
OR13C9	286362	broad.mit.edu	37	9	107380045	107380045	+	Silent	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr9:107380045C>G	uc011lvr.1	-	1	441	c.441G>C	c.(439-441)GGG>GGC	p.G147G		NM_001001956	NP_001001956	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CAAACCAGGACCCAACAGCCA	0.448			NA											30	69					0	0	0.00632	0	0
ZNF462	58499	broad.mit.edu	37	9	109687218	109687218	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr9:109687218C>G	uc004bcz.2	+	3	1314	c.1025C>G	c.(1024-1026)TCT>TGT	p.S342C	ZNF462_uc010mto.2_Missense_Mutation_p.S190C|ZNF462_uc004bda.2_Missense_Mutation_p.S190C	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	342					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						TCGCCCATGTCTTACCCTCAG	0.483			NA											15	40					0	0	0.00245	0	0
ACTL7B	10880	broad.mit.edu	37	9	111617550	111617550	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr9:111617550G>T	uc004bdi.2	-	1	726	c.661C>A	c.(661-663)CGC>AGC	p.R221S		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	actin-like 7B	221						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			pancreas(1)	1						TAGTCGGCGCGGCTGGTCAGG	0.662			NA											14	43					4.3838e-07	5.50411e-07	0.001855	1	0
AKNA	80709	broad.mit.edu	37	9	117138926	117138926	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr9:117138926C>A	uc004biq.3	-	2	1296	c.1161G>T	c.(1159-1161)AAG>AAT	p.K387N	AKNA_uc004bio.3_5'UTR|AKNA_uc004bip.3_Missense_Mutation_p.K306N|AKNA_uc004bir.3_Missense_Mutation_p.K387N|AKNA_uc004bis.3_Missense_Mutation_p.K387N|AKNA_uc010mve.2_Missense_Mutation_p.K268N|AKNA_uc004biu.1_Missense_Mutation_p.K128N|AKNA_uc004biv.1_Missense_Mutation_p.K387N|AKNA_uc004biw.1_Missense_Mutation_p.K387N	NM_030767	NP_110394	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	387					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(2)	6						GGGCCTGAGGCTTCCTGTTGT	0.587			NA											22	58					1.85244e-09	2.51694e-09	0.00333	1	0
TLR4	7099	broad.mit.edu	37	9	120476015	120476015	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr9:120476015A>T	uc004bjz.2	+	3	1900	c.1609A>T	c.(1609-1611)ACG>TCG	p.T537S	TLR4_uc004bka.2_Missense_Mutation_p.T497S|TLR4_uc004bkb.2_Missense_Mutation_p.T337S	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	537	LRR 17.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TTCATTGGATACGTTTCCTTA	0.403			NA											19	33					0	0	0.012319	0	0
SLC2A8	29988	broad.mit.edu	37	9	130166264	130166264	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr9:130166264G>T	uc004bqu.2	+	7	939	c.894G>T	c.(892-894)GTG>GTT	p.V298V	SLC2A8_uc010mxj.2_Silent_p.V298V|SLC2A8_uc004bqv.2_5'Flank	NM_014580	NP_055395	Q9NY64	GTR8_HUMAN	solute carrier family 2 (facilitated glucose	298	Helical; Name=8; (Potential).					cytoplasmic vesicle membrane|integral to plasma membrane	D-glucose transmembrane transporter activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2						CGGTCGTCGTGGGTGTCATCC	0.652			NA											7	23					8.12818e-05	9.26203e-05	0.001984	1	0
SPTAN1	6709	broad.mit.edu	37	9	131356466	131356466	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr9:131356466G>T	uc004bvl.3	+	24	3341	c.3228G>T	c.(3226-3228)CTG>CTT	p.L1076L	SPTAN1_uc011mbg.1_Silent_p.L1056L|SPTAN1_uc011mbh.1_Silent_p.L1088L|SPTAN1_uc004bvm.3_Silent_p.L1076L|SPTAN1_uc004bvn.3_Silent_p.L1056L	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1076	Spectrin 11.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						ATCATTCTCTGCTGGAACTGG	0.448	NSCLC(120;833 1744 2558 35612 37579)		NA											24	64					2.27525e-19	3.77169e-19	0.003954	1	0
ZER1	10444	broad.mit.edu	37	9	131502332	131502332	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr9:131502332G>A	uc004bwa.1	-	13	2353	c.1920C>T	c.(1918-1920)CAC>CAT	p.H640H		NM_006336	NP_006327	Q7Z7L7	ZER1_HUMAN	zyg-11 homolog B (C. elegans)-like	640	ARM 4.				ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			ovary(1)	1						CAAACATGATGTGGGAGAGGA	0.582			NA											9	36					0	0	0.006214	0	0
MXRA5	25878	broad.mit.edu	37	X	3228872	3228872	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:3228872C>A	uc004crg.3	-	7	7529	c.7372G>T	c.(7372-7374)GGG>TGG	p.G2458W		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2458	Ig-like C2-type 9.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CGACTGCCCCCGGCTGCTATC	0.577			NA											14	33					1.5842e-08	2.09374e-08	0.001855	1	0
NLGN4X	57502	broad.mit.edu	37	X	5811275	5811275	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:5811275G>T	uc010ndh.2	-	6	2535	c.2034C>A	c.(2032-2034)ACC>ACA	p.T678T	NLGN4X_uc004crp.2_Silent_p.T698T|NLGN4X_uc004crq.2_Silent_p.T678T|NLGN4X_uc010ndi.2_Silent_p.T715T|NLGN4X_uc004crr.2_Silent_p.T678T|NLGN4X_uc010ndj.2_Silent_p.T678T	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	678	Helical; (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						CGACGGCAATGGTGACACTTA	0.512			NA											46	119					1.81118e-26	3.18956e-26	0.01441	1	0
ARHGAP6	395	broad.mit.edu	37	X	11204553	11204553	+	Splice_Site	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:11204553T>C	uc004cup.1	-	5	1951	c.1078_splice	c.e5-1	p.G360_splice	ARHGAP6_uc004cuo.1_Splice_Site|ARHGAP6_uc004cur.1_Splice_Site_p.G360_splice|ARHGAP6_uc004cum.1_Splice_Site_p.G157_splice|ARHGAP6_uc004cun.1_Splice_Site_p.G180_splice|ARHGAP6_uc010neb.1_Splice_Site_p.G182_splice|ARHGAP6_uc011mif.1_Splice_Site_p.G157_splice	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1						actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						CATGGCACCCTGCAAGTGACA	0.443			NA											9	117					0	0	0.004482	0	0
ACE2	59272	broad.mit.edu	37	X	15603664	15603664	+	Silent	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:15603664C>G	uc004cxa.1	-	7	1002	c.834G>C	c.(832-834)CTG>CTC	p.L278L	ACE2_uc004cxb.2_Silent_p.L278L	NM_021804	NP_068576	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2 precursor	278	Extracellular (Potential).				angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			ovary(3)	3	Hepatocellular(33;0.183)				Moexipril(DB00691)	TCAAAGAGTACAGATTTGTCC	0.328			NA											11	169					0	0	0.010729	0	0
PPEF1	5475	broad.mit.edu	37	X	18822086	18822086	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:18822086A>G	uc004cyq.2	+	14	1623	c.1142A>G	c.(1141-1143)TAT>TGT	p.Y381C	PPEF1_uc004cyp.2_Missense_Mutation_p.Y353C|PPEF1_uc004cyr.2_Intron|PPEF1_uc004cys.2_Missense_Mutation_p.Y381C|PPEF1_uc011mja.1_Missense_Mutation_p.Y316C|PPEF1_uc011mjb.1_Missense_Mutation_p.Y325C	NM_006240	NP_006231	O14829	PPE1_HUMAN	protein phosphatase with EF hand calcium-binding	381	Catalytic.				detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity				0	Hepatocellular(33;0.183)					GGGGGCTGCTATTTTGGACCA	0.418			NA											39	68					0	0	0.006999	0	0
DMD	1756	broad.mit.edu	37	X	31462673	31462673	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:31462673G>T	uc004dda.1	-	60	9253	c.9009C>A	c.(9007-9009)ACC>ACA	p.T3003T	DMD_uc004dcq.1_Silent_p.T274T|DMD_uc004dcr.1_Silent_p.T543T|DMD_uc004dcs.1_Silent_p.T543T|DMD_uc004dct.1_Silent_p.T543T|DMD_uc004dcu.1_Silent_p.T543T|DMD_uc004dcv.1_Silent_p.T543T|DMD_uc004dcw.2_Silent_p.T1659T|DMD_uc004dcx.2_Silent_p.T1662T|DMD_uc004dcz.2_Silent_p.T2880T|DMD_uc004dcy.1_Silent_p.T2999T|DMD_uc004ddb.1_Silent_p.T2995T	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3003	Spectrin 22.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGCCCAAAGTGGTAAGCTGGC	0.478			NA											6	63					2.7689e-08	3.63116e-08	0.001984	1	0
FAM47B	170062	broad.mit.edu	37	X	34961736	34961736	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:34961736C>A	uc004ddi.1	+	1	806	c.788C>A	c.(787-789)CCT>CAT	p.P263H		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	263	Pro-rich.									ovary(3)|breast(1)	4						TGCCCAGAGCCTCCCAAGACT	0.622			NA											37	61					1.07121e-22	1.82482e-22	0.006999	1	0
FAM47C	442444	broad.mit.edu	37	X	37029346	37029346	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:37029346G>T	uc004ddl.1	+	1	2877	c.2863G>T	c.(2863-2865)GAA>TAA	p.E955*		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	955										ovary(3)	3						AAGAAGTGATGAACCTTTGAT	0.438			NA											51	122					8.5822e-43	1.58118e-42	0.01441	1	0
OTC	5009	broad.mit.edu	37	X	38226663	38226663	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:38226663G>C	uc004def.3	+	2	411	c.197G>C	c.(196-198)AGG>ACG	p.R66T		NM_000531	NP_000522	P00480	OTC_HUMAN	ornithine carbamoyltransferase precursor	66					arginine biosynthetic process|urea cycle	mitochondrial matrix|ornithine carbamoyltransferase complex	ornithine carbamoyltransferase activity			ovary(1)|breast(1)	2					L-Citrulline(DB00155)|L-Ornithine(DB00129)	CTGAAATTTAGGATAAAACAG	0.373			NA											27	56					0	0	0.013726	0	0
MED14	9282	broad.mit.edu	37	X	40572200	40572200	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:40572200C>A	uc004dex.3	-	6	887	c.747G>T	c.(745-747)AAG>AAT	p.K249N	MED14_uc010nhe.1_Missense_Mutation_p.K133N	NM_004229	NP_004220	O60244	MED14_HUMAN	mediator complex subunit 14	249	Interaction with STAT2.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4						GAATTTCTAGCTTGAGAAGAC	0.358			NA											7	17					5.18039e-06	6.17277e-06	0.00308	1	0
CCDC120	90060	broad.mit.edu	37	X	48921447	48921447	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:48921447A>T	uc010nik.2	+	5	746	c.239A>T	c.(238-240)CAG>CTG	p.Q80L	CCDC120_uc011mmq.1_Missense_Mutation_p.Q68L|CCDC120_uc004dmf.2_Missense_Mutation_p.Q80L|CCDC120_uc010nil.2_Missense_Mutation_p.Q80L|CCDC120_uc011mmr.1_Missense_Mutation_p.Q80L|CCDC120_uc011mms.1_Missense_Mutation_p.Q68L	NM_033626	NP_296375	Q96HB5	CC120_HUMAN	coiled-coil domain containing 120 isoform 3	80							protein binding			pancreas(1)	1						GAACGGCCCCAGTTGGTCCGC	0.667			NA											4	11					0	0	0.009096	0	0
MAGED1	9500	broad.mit.edu	37	X	51639760	51639760	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:51639760G>A	uc004dpm.2	+	4	1104	c.1009G>A	c.(1009-1011)GCT>ACT	p.A337T	MAGED1_uc004dpn.2_Missense_Mutation_p.A393T|MAGED1_uc004dpo.2_Missense_Mutation_p.A337T	NM_001005332	NP_001005332	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1 isoform b	337	Pro-rich.|22 X 6 AA tandem repeats of W-[PQ]-X-P-X- X.|4.				apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			ovary(3)	3	Ovarian(276;0.236)					GAACCCAGTCGCTTGGCAGAA	0.612			NA								Multiple Myeloma(10;0.10)			14	53					0	0	0.006122	0	0
MAGED1	9500	broad.mit.edu	37	X	51640681	51640681	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:51640681T>A	uc004dpm.2	+	6	1620	c.1525T>A	c.(1525-1527)TAT>AAT	p.Y509N	MAGED1_uc004dpn.2_Missense_Mutation_p.Y565N|MAGED1_uc004dpo.2_Missense_Mutation_p.Y509N	NM_001005332	NP_001005332	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1 isoform b	509	MAGE.				apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			ovary(3)	3	Ovarian(276;0.236)					CACTGATGTTTATCCAGAAAT	0.488			NA								Multiple Myeloma(10;0.10)			5	77					0	0	0.001168	0	0
ALAS2	212	broad.mit.edu	37	X	55040070	55040070	+	Silent	SNP	T	T	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:55040070T>G	uc004dua.3	-	10	1587	c.1449A>C	c.(1447-1449)GCA>GCC	p.A483A	ALAS2_uc004dub.3_Silent_p.A470A|ALAS2_uc004dud.3_Silent_p.A446A	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	483					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	TGTTGAGTGCTGCATTGCCCA	0.547			NA											5	37					0	0	0.000602	0	0
FAM123B	139285	broad.mit.edu	37	X	63412380	63412380	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:63412380C>G	uc004dvo.2	-	2	1060	c.787G>C	c.(787-789)GAG>CAG	p.E263Q		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	263					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						GCACAGGCCTCCATGGGTTTT	0.547			NA											16	215					0	0	0.00499	0	0
ITGB1BP2	26548	broad.mit.edu	37	X	70521703	70521703	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:70521703C>G	uc004dzr.1	+	1	76	c.47C>G	c.(46-48)CCT>CGT	p.P16R	BCYRN1_uc011mpt.1_Intron|ITGB1BP2_uc004dzs.1_5'UTR	NM_012278	NP_036410	Q9UKP3	ITBP2_HUMAN	integrin beta 1 binding protein 2	16	Cys-rich.|CHORD 1.				muscle organ development|signal transduction		SH3 domain binding			ovary(1)	1	Renal(35;0.156)					CACTTTGACCCTAATACCAAC	0.532			NA											3	82					0	0	0.004672	0	0
TAF1	6872	broad.mit.edu	37	X	70627911	70627911	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:70627911C>A	uc004dzu.3	+	28	4342	c.4291C>A	c.(4291-4293)CGC>AGC	p.R1431S	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.R1452S|TAF1_uc004dzv.3_Missense_Mutation_p.R605S|TAF1_uc010nld.1_RNA|TAF1_uc010nle.1_RNA|TAF1_uc010nlf.1_5'UTR|TAF1_uc004dzx.2_RNA|TAF1_uc004dzy.2_RNA	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	1431	Bromo 1.|Interaction with ASF1A and ASF1B.|Protein kinase 2.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				ACAAACACTCCGCGAAAACGT	0.453			NA											9	152					0.00621372	0.00664495	0.006214	1	0
OGT	8473	broad.mit.edu	37	X	70787503	70787503	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:70787503G>T	uc004eaa.1	+	20	2960	c.2743G>T	c.(2743-2745)GGC>TGC	p.G915C	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Missense_Mutation_p.G905C|OGT_uc004eac.2_Missense_Mutation_p.G776C|OGT_uc004ead.2_Missense_Mutation_p.G534C	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	915					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					CGTCAGGAGAGGCCAGCTGGC	0.527			NA											6	49					2.0095e-06	2.44603e-06	0.001984	1	0
PHKA1	5255	broad.mit.edu	37	X	71855067	71855067	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:71855067C>T	uc004eax.3	-	16	1953	c.1652G>A	c.(1651-1653)TGT>TAT	p.C551Y	PHKA1_uc004eay.3_Missense_Mutation_p.C551Y|PHKA1_uc011mqi.1_Missense_Mutation_p.C551Y	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform	551					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					CCAGCGGCTACAGAGGTAGGA	0.483			NA											11	59					0	0	0.008291	0	0
CDX4	1046	broad.mit.edu	37	X	72667527	72667527	+	Silent	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:72667527C>A	uc011mqk.1	+	1	438	c.438C>A	c.(436-438)GCC>GCA	p.A146A		NM_005193	NP_005184	O14627	CDX4_HUMAN	caudal type homeobox 4	146						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(35;0.156)					CCGCCAAGGCCAGTTCCCCCA	0.642			NA											15	28					1.52009e-12	2.21639e-12	0.003163	1	0
ABCB7	22	broad.mit.edu	37	X	74290242	74290242	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:74290242C>T	uc004eca.2	-	10	1348	c.1323G>A	c.(1321-1323)ATG>ATA	p.M441I	ABCB7_uc004ebz.2_Missense_Mutation_p.M442I|ABCB7_uc011mqn.1_Missense_Mutation_p.M415I|ABCB7_uc010nls.2_Missense_Mutation_p.M402I|ABCB7_uc010nlt.2_Missense_Mutation_p.M401I	NM_004299	NP_004290	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B, member 7	441					cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			ovary(1)	1						ACAAGGTGTTCATATCTATGA	0.358			NA											17	224					0	0	0.00499	0	0
ATRX	546	broad.mit.edu	37	X	76937081	76937081	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:76937081C>G	uc004ecp.3	-	9	3899	c.3667G>C	c.(3667-3669)GAA>CAA	p.E1223Q	ATRX_uc004ecq.3_Missense_Mutation_p.E1185Q|ATRX_uc004eco.3_Missense_Mutation_p.E1008Q|ATRX_uc004ecr.2_Missense_Mutation_p.E1155Q|ATRX_uc010nlx.1_Missense_Mutation_p.E1194Q|ATRX_uc010nly.1_Missense_Mutation_p.E1168Q	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1223					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	ATTTTCTGTTCATCGCTGCTT	0.343			NA	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						14	182					0	0	0.00245	0	0
ATP7A	538	broad.mit.edu	37	X	77266706	77266706	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:77266706G>T	uc004ecx.3	+	8	2063	c.1903G>T	c.(1903-1905)GAT>TAT	p.D635Y	ATP7A_uc004ecw.2_3'UTR	NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	635	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						GGTCAAGAAGGATCGGTCAGC	0.303			NA											7	121					0.00198382	0.00216243	0.001984	1	0
BRWD3	254065	broad.mit.edu	37	X	79980529	79980529	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:79980529G>A	uc004edt.2	-	15	1687	c.1424C>T	c.(1423-1425)CCA>CTA	p.P475L	BRWD3_uc004edo.2_Missense_Mutation_p.P71L|BRWD3_uc004edp.2_Missense_Mutation_p.P304L|BRWD3_uc004edq.2_Missense_Mutation_p.P71L|BRWD3_uc010nmj.1_Missense_Mutation_p.P71L|BRWD3_uc004edr.2_Missense_Mutation_p.P145L|BRWD3_uc004eds.2_Missense_Mutation_p.P71L|BRWD3_uc004edu.2_Missense_Mutation_p.P145L|BRWD3_uc004edv.2_Missense_Mutation_p.P71L|BRWD3_uc004edw.2_Missense_Mutation_p.P71L|BRWD3_uc004edx.2_Missense_Mutation_p.P71L|BRWD3_uc004edy.2_Missense_Mutation_p.P71L|BRWD3_uc004edz.2_Missense_Mutation_p.P145L|BRWD3_uc004eea.2_Missense_Mutation_p.P145L|BRWD3_uc004eeb.2_Missense_Mutation_p.P71L	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	475	WD 8.									ovary(4)	4						TTGATCAAATGGATGGGCTTC	0.358			NA											3	46					0	0	0.004672	0	0
POU3F4	5456	broad.mit.edu	37	X	82763626	82763626	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:82763626G>A	uc004eeg.2	+	1	358	c.294G>A	c.(292-294)TCG>TCA	p.S98S		NM_000307	NP_000298	P49335	PO3F4_HUMAN	POU domain, class 3, transcription factor 4	98					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						ATCACCGCTCGCCACACGTAG	0.672			NA											7	11					0	0	0.001984	0	0
POU3F4	5456	broad.mit.edu	37	X	82763897	82763897	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:82763897C>A	uc004eeg.2	+	1	629	c.565C>A	c.(565-567)CCA>ACA	p.P189T		NM_000307	NP_000298	P49335	PO3F4_HUMAN	POU domain, class 3, transcription factor 4	189	POU-specific.				sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CGAGGAGACGCCAACCTCTGA	0.602			NA											22	13					3.62473e-10	4.96478e-10	0.012319	1	0
CPXCR1	53336	broad.mit.edu	37	X	88009014	88009014	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:88009014C>A	uc004efd.3	+	3	858	c.599C>A	c.(598-600)TCG>TAG	p.S200*	CPXCR1_uc004efc.3_Nonsense_Mutation_p.S200*	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	200						intracellular	zinc ion binding			ovary(3)	3						AGAAGGCCTTCGAGGGTGCAC	0.418			NA											16	26					6.31663e-08	8.15747e-08	0.003163	1	0
TGIF2LX	90316	broad.mit.edu	37	X	89177192	89177192	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:89177192T>A	uc004efe.2	+	2	157	c.108T>A	c.(106-108)AAT>AAA	p.N36K		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	36						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						TGTCGAGAAATAACGCAGATA	0.572			NA											18	26					0	0	0.004289	0	0
TGIF2LX	90316	broad.mit.edu	37	X	89177194	89177194	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:89177194A>G	uc004efe.2	+	2	159	c.110A>G	c.(109-111)AAC>AGC	p.N37S		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	37						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						TCGAGAAATAACGCAGATACA	0.562			NA											17	25					0	0	0.003755	0	0
XKRX	402415	broad.mit.edu	37	X	100183084	100183084	+	Silent	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:100183084G>C	uc004egn.2	-	1	815	c.210C>G	c.(208-210)ACC>ACG	p.T70T	XKRX_uc011mre.1_5'UTR	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related,	70	Helical; (Potential).					integral to membrane|plasma membrane				breast(1)	1						AGAAAGAAAAGGTGTATGTCA	0.383			NA											52	66					0	0	0.01441	0	0
ARMCX5	64860	broad.mit.edu	37	X	101857749	101857749	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:101857749C>A	uc004ejg.2	+	6	1561	c.680C>A	c.(679-681)GCC>GAC	p.A227D	ARMCX5_uc004ejh.2_Missense_Mutation_p.A227D	NM_022838	NP_073749	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	227							binding			ovary(1)	1						TGGTCAAGGGCCAGGTATATT	0.473			NA											9	120					2.17888e-05	2.52959e-05	0.006214	1	0
BHLHB9	80823	broad.mit.edu	37	X	102004609	102004609	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:102004609C>G	uc010nog.2	+	4	1257	c.686C>G	c.(685-687)GCT>GGT	p.A229G	BHLHB9_uc011mrq.1_Missense_Mutation_p.A229G|BHLHB9_uc011mrr.1_Missense_Mutation_p.A229G|BHLHB9_uc011mrs.1_Missense_Mutation_p.A229G|BHLHB9_uc011mrt.1_Missense_Mutation_p.A229G|BHLHB9_uc004ejo.2_Missense_Mutation_p.A229G|BHLHB9_uc011mru.1_Missense_Mutation_p.A229G|BHLHB9_uc011mrv.1_Missense_Mutation_p.A229G	NM_001142526	NP_001135998	Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class	229						cytoplasm|nucleus	binding			ovary(2)	2						GTAACTCCAGCTGTGTTAGGA	0.473			NA											36	167					0	0	0.004878	0	0
TCEAL5	340543	broad.mit.edu	37	X	102529194	102529194	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:102529194G>T	uc004ejz.1	-	3	593	c.298C>A	c.(298-300)CCG>ACG	p.P100T		NM_001012979	NP_001012997	Q5H9L2	TCAL5_HUMAN	transcription elongation factor A (SII)-like 5	100					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(1)|breast(1)	2						GCGGCCCGCGGCTGGCTCTCT	0.592			NA											17	139					3.52763e-06	4.24066e-06	0.00499	1	0
RAB9B	51209	broad.mit.edu	37	X	103080375	103080375	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:103080375G>A	uc004ell.1	-	3	625	c.340C>T	c.(340-342)CCT>TCT	p.P114S	RAB9B_uc004eli.1_Intron	NM_016370	NP_057454	Q9NP90	RAB9B_HUMAN	RAB9B, member RAS oncogene family	114					Golgi to endosome transport|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|protein binding			lung(3)	3						AAATGCTCAGGGTCCTTCACA	0.483			NA											165	179					0	0	0.01441	0	0
IRS4	8471	broad.mit.edu	37	X	107978507	107978507	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:107978507G>T	uc004eoc.2	-	1	1101	c.1068C>A	c.(1066-1068)TCC>TCA	p.S356S		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	356						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GCCTCCTAGCGGACAGCAGGG	0.622			NA											16	199					2.31682e-05	2.68056e-05	0.003163	1	0
ACSL4	2182	broad.mit.edu	37	X	108911376	108911376	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:108911376C>A	uc004eoi.2	-	12	1897	c.1392G>T	c.(1390-1392)CAG>CAT	p.Q464H	ACSL4_uc004eoj.2_Missense_Mutation_p.Q423H|ACSL4_uc004eok.2_Missense_Mutation_p.Q423H|ACSL4_uc010npp.1_Missense_Mutation_p.Q464H	NM_022977	NP_075266	O60488	ACSL4_HUMAN	acyl-CoA synthetase long-chain family member 4	464	Cytoplasmic (Potential).				fatty acid metabolic process|learning or memory|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(1)|lung(1)|ovary(1)	3					Icosapent(DB00159)|Troglitazone(DB00197)	GTCCATAACCCTGGCCAATTG	0.473	Pancreas(188;358 2127 38547 41466 45492)		NA											6	114					8.12818e-05	9.26203e-05	0.001984	1	0
C1GALT1C1	29071	broad.mit.edu	37	X	119760065	119760065	+	Nonstop_Mutation	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:119760065T>A	uc004esy.2	-	3	1304	c.957A>T	c.(955-957)TGA>TGT	p.*319C	C1GALT1C1_uc004esz.2_Nonstop_Mutation_p.*319C	NM_152692	NP_689905	Q96EU7	C1GLC_HUMAN	C1GALT1-specific chaperone 1	319						integral to membrane					0						CTACCACTTCTCAGTCATTGT	0.373			NA											39	44					0	0	0.00874	0	0
STAG2	10735	broad.mit.edu	37	X	123210221	123210221	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:123210221T>C	uc004etz.3	+	25	2912	c.2573T>C	c.(2572-2574)CTG>CCG	p.L858P	STAG2_uc004eua.2_Missense_Mutation_p.L858P|STAG2_uc004eub.2_Missense_Mutation_p.L858P|STAG2_uc004euc.2_Missense_Mutation_p.L858P|STAG2_uc004eud.2_Missense_Mutation_p.L858P|STAG2_uc004eue.2_Missense_Mutation_p.L858P	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	858					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						ATTGAAGCTCTGCACAAGAGA	0.343			NA											12	152					0	0	0.013537	0	0
ODZ1	10178	broad.mit.edu	37	X	123515010	123515010	+	Silent	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:123515010G>C	uc004euj.2	-	31	7618	c.7554C>G	c.(7552-7554)GTC>GTG	p.V2518V	ODZ1_uc011muj.1_Silent_p.V2524V|ODZ1_uc010nqy.2_Silent_p.V2525V	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2518	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						AAACAGAAGGGACAGCAGCAA	0.458			NA											15	146					0	0	0.003163	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125299761	125299761	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:125299761G>A	uc004euk.1	-	1	174	c.147C>T	c.(145-147)CGC>CGT	p.R49R		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	49										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						GCACCAGCCTGCGACGCGTCG	0.726			NA											26	27					0	0	0.00632	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128881584	128881584	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:128881584C>A	uc004eut.1	+	7	736	c.492C>A	c.(490-492)GAC>GAA	p.D164E	XPNPEP2_uc011mum.1_Missense_Mutation_p.D164E	NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	164					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						TCTCTGCAGACACCTGGGAGA	0.512			NA											47	47					7.88023e-25	1.37701e-24	0.01441	1	0
ARHGAP36	158763	broad.mit.edu	37	X	130217848	130217848	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:130217848G>A	uc004evz.2	+	4	805	c.460G>A	c.(460-462)GTG>ATG	p.V154M	ARHGAP36_uc004ewa.2_Missense_Mutation_p.V142M|ARHGAP36_uc004ewb.2_Missense_Mutation_p.V123M|ARHGAP36_uc004ewc.2_Missense_Mutation_p.V18M	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	154	Arg-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						TCGGGGAAACGTGGTGCGAAG	0.632			NA											9	128					0	0	0.008291	0	0
IGSF1	3547	broad.mit.edu	37	X	130416645	130416645	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:130416645C>A	uc004ewd.2	-	7	1257	c.1019G>T	c.(1018-1020)AGC>ATC	p.S340I	IGSF1_uc004ewe.3_Missense_Mutation_p.S329I|IGSF1_uc004ewf.2_Missense_Mutation_p.S320I	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	340	Ig-like C2-type 4.|Extracellular (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						ACACCGTAGGCTCACATTCTG	0.498			NA											8	109					5.18039e-06	6.17277e-06	0.00308	1	0
DDX26B	203522	broad.mit.edu	37	X	134680668	134680668	+	Silent	SNP	A	A	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:134680668A>T	uc004eyw.3	+	5	834	c.471A>T	c.(469-471)CTA>CTT	p.L157L		NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	157	VWFA.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GAAGTGAACTAACCAAAGAAC	0.433			NA											90	96					0	0	0.01441	0	0
GPR112	139378	broad.mit.edu	37	X	135428834	135428834	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:135428834T>C	uc004ezu.1	+	6	3260	c.2969T>C	c.(2968-2970)TTG>TCG	p.L990S	GPR112_uc010nsb.1_Missense_Mutation_p.L785S|GPR112_uc010nsc.1_Missense_Mutation_p.L757S	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	990	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					GCTACGTCCTTGTCTGATGGT	0.493			NA											20	256					0	0	0.008871	0	0
GPR101	83550	broad.mit.edu	37	X	136112696	136112696	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:136112696G>T	uc011mwh.1	-	1	1138	c.1138C>A	c.(1138-1140)CGT>AGT	p.R380S		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	380	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					CTGTTACGACGACTGGGTGGG	0.512			NA											6	161					0.00116845	0.00128189	0.001168	1	0
F9	2158	broad.mit.edu	37	X	138643882	138643882	+	Silent	SNP	C	C	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:138643882C>G	uc004fas.1	+	8	1067	c.1038C>G	c.(1036-1038)CTC>CTG	p.L346L	F9_uc004fat.1_Silent_p.L308L	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	346	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	ACATCTTCCTCAAATTTGGAT	0.453			NA											65	154					0	0	0.01441	0	0
MAGEC2	51438	broad.mit.edu	37	X	141291679	141291679	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:141291679G>T	uc004fbu.1	-	3	443	c.95C>A	c.(94-96)ACA>AAA	p.T32K		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	32						cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TTCCTCATCTGTGGGATGCTG	0.522			NA								HNSCC(46;0.14)			107	139					5.67068e-62	1.06208e-61	0.01441	1	0
AFF2	2334	broad.mit.edu	37	X	147743758	147743758	+	Silent	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:147743758G>T	uc004fcp.2	+	3	989	c.510G>T	c.(508-510)CTG>CTT	p.L170L	AFF2_uc004fco.2_Silent_p.L166L|AFF2_uc004fcq.2_Silent_p.L166L|AFF2_uc004fcr.2_Silent_p.L166L|AFF2_uc011mxb.1_Silent_p.L170L|AFF2_uc004fcs.2_Silent_p.L166L	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	170					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					GCACTGTACTGGCAAGCCAGG	0.468			NA											17	188					4.75885e-15	7.4515e-15	0.00499	1	0
AFF2	2334	broad.mit.edu	37	X	148059973	148059973	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:148059973G>T	uc004fcp.2	+	18	4037	c.3558G>T	c.(3556-3558)ATG>ATT	p.M1186I	AFF2_uc004fcq.2_Missense_Mutation_p.M1176I|AFF2_uc004fcr.2_Missense_Mutation_p.M1147I|AFF2_uc011mxb.1_Missense_Mutation_p.M1151I|AFF2_uc004fcs.2_Missense_Mutation_p.M1151I|AFF2_uc011mxc.1_Missense_Mutation_p.M827I	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1186					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					GATCACTGATGGAATATTTTA	0.363			NA											54	64					5.22555e-25	9.15485e-25	0.01441	1	0
CD99L2	83692	broad.mit.edu	37	X	149945946	149945946	+	Missense_Mutation	SNP	C	C	G	rs143706982		TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:149945946C>G	uc004fel.2	-	8	624	c.506G>C	c.(505-507)CGG>CCG	p.R169P	CD99L2_uc004fek.2_RNA|CD99L2_uc004fem.2_Missense_Mutation_p.R120P|CD99L2_uc004fen.2_Missense_Mutation_p.R97P|CD99L2_uc004feo.2_RNA|CD99L2_uc011myb.1_Missense_Mutation_p.R96P	NM_031462	NP_113650	Q8TCZ2	C99L2_HUMAN	CD99 antigen-like 2 isoform E3'-E4'-E3-E4	169	Extracellular (Potential).				cell adhesion	cell junction|integral to membrane				large_intestine(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GCTGCCGTACCGGCCATCACC	0.493			NA											11	92					0	0	0.001855	0	0
CD99L2	83692	broad.mit.edu	37	X	149962192	149962192	+	Silent	SNP	A	A	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:149962192A>G	uc004fel.2	-	7	586	c.468T>C	c.(466-468)GGT>GGC	p.G156G	CD99L2_uc004fek.2_RNA|CD99L2_uc004fem.2_Silent_p.G107G|CD99L2_uc004fen.2_Silent_p.G84G|CD99L2_uc004feo.2_RNA|CD99L2_uc011myb.1_Intron	NM_031462	NP_113650	Q8TCZ2	C99L2_HUMAN	CD99 antigen-like 2 isoform E3'-E4'-E3-E4	156	Extracellular (Potential).				cell adhesion	cell junction|integral to membrane				large_intestine(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGTATTCTCCACCCCCTACTA	0.373			NA											3	51					0	0	0.009096	0	0
GABRE	2564	broad.mit.edu	37	X	151123293	151123293	+	Silent	SNP	G	G	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:151123293G>A	uc004ffi.2	-	9	1455	c.1401C>T	c.(1399-1401)ACC>ACT	p.T467T	GABRE_uc011myd.1_RNA	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	467	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CCTGCTGCCAGGTACTGCCCT	0.552			NA											6	67					0	0	0.001984	0	0
PLXNB3	5365	broad.mit.edu	37	X	153039434	153039434	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:153039434G>C	uc004fii.2	+	20	3574	c.3400G>C	c.(3400-3402)GCC>CCC	p.A1134P	PLXNB3_uc010nuk.2_Missense_Mutation_p.A1157P|PLXNB3_uc011mzd.1_Missense_Mutation_p.A773P|PLXNB3_uc004fij.1_5'Flank|SRPK3_uc004fik.2_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	1134	IPT/TIG 3.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					AGTGGACTTCGCCAGTGCCAG	0.687			NA											44	76					0	0	0.01441	0	0
SRPK3	26576	broad.mit.edu	37	X	153048509	153048509	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:153048509G>T	uc004fil.2	+	7	716	c.684G>T	c.(682-684)AGG>AGT	p.R228S	SRPK3_uc004fik.2_Missense_Mutation_p.R294S|SRPK3_uc010nul.2_Missense_Mutation_p.R186S|SRPK3_uc004fin.2_Missense_Mutation_p.R228S|SRPK3_uc004fim.2_Missense_Mutation_p.R228S	NM_014370	NP_055185	Q9UPE1	SRPK3_HUMAN	serine arginine rich protein-specific kinase 3	228	Protein kinase.				cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			pancreas(2)|lung(1)	3	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CTTACATCAGGCGCCTGGCTG	0.657	Esophageal Squamous(167;766 3400 32156)		NA											4	127					8.12818e-05	9.26203e-05	0.001984	1	0
PLXNA3	55558	broad.mit.edu	37	X	153694838	153694838	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:153694838C>A	uc004flm.2	+	16	3092	c.2919C>A	c.(2917-2919)AGC>AGA	p.S973R		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	973	IPT/TIG 2.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGAGGGACAGCGAGTGCCAGT	0.692			NA											10	119					0.000442599	0.000492746	0.006214	1	0
FUNDC2	65991	broad.mit.edu	37	X	154261737	154261737	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chrX:154261737T>A	uc004fmw.2	+	2	343	c.193T>A	c.(193-195)TGG>AGG	p.W65R		NM_023934	NP_076423	Q9BWH2	FUND2_HUMAN	FUN14 domain containing 2	65						mitochondrion					0	all_cancers(53;3.51e-17)|all_epithelial(53;5.13e-11)|all_lung(58;3.84e-07)|Lung NSC(58;1.2e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GAAGCAGCCATGGTGGCGTAA	0.428			NA											6	165					0	0	0.001984	0	0
HRNR	388697	broad.mit.edu	37	1	152187509	152187509	+	Frame_Shift_Del	DEL	C	C	-			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr1:152187509delC	uc001ezt.1	-	3	6672	c.6596delG	c.(6595-6597)GGCfs	p.G2199fs		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2199	24.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCATGTTGGCCGTGGCTGGA	0.627			NA											22	1146	---	---	---	---	NA	NA	NA	NA	NA
B4GALNT1	2583	broad.mit.edu	37	12	58020563	58020563	+	Frame_Shift_Del	DEL	G	G	-			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr12:58020563delG	uc001spg.1	-	11	1998	c.1566delC	c.(1564-1566)TTCfs	p.F522fs	B4GALNT1_uc010sru.1_Frame_Shift_Del_p.F467fs	NM_001478	NP_001469	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	522	Lumenal (Potential).				lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity				0	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			GGTGTTTGAAGAAGAGCAGCC	0.597			NA											53	145	---	---	---	---	NA	NA	NA	NA	NA
NEK3	4752	broad.mit.edu	37	13	52728029	52728029	+	Splice_Site	DEL	C	C	-			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr13:52728029delC	uc001vgi.2	-	4	544	c.309_splice	c.e4+1	p.M103_splice	NEK3_uc001vgg.2_Splice_Site_p.M97_splice|NEK3_uc001vgh.2_Splice_Site_p.M124_splice|NEK3_uc010tgx.1_Splice_Site|NEK3_uc010tgy.1_Splice_Site_p.M103_splice	NM_152720	NP_689933	P51956	NEK3_HUMAN	NIMA-related kinase 3 isoform a						cell division|mitosis	nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.034)|Hepatocellular(98;0.065)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.81e-08)		CAATCTCTTACCATGTCTTCA	0.333			NA											13	111	---	---	---	---	NA	NA	NA	NA	NA
MYO15A	51168	broad.mit.edu	37	17	18044107	18044107	+	Frame_Shift_Del	DEL	C	C	-			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:18044107delC	uc010vxh.1	+	20	5705	c.5367delC	c.(5365-5367)AACfs	p.N1789fs		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1789	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					CCAGGTGCAACCCCTTGTTCA	0.522			NA									OREG0024223	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	66	---	---	---	---	NA	NA	NA	NA	NA
NF1	4763	broad.mit.edu	37	17	29654741	29654742	+	Frame_Shift_Ins	INS	-	-	T			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr17:29654741_29654742insT	uc002hgg.2	+	38	5826_5827	c.5493_5494insT	c.(5491-5496)TGGGAAfs	p.W1831fs	NF1_uc002hgh.2_Frame_Shift_Ins_p.W1810fs|NF1_uc002hgi.1_Frame_Shift_Ins_p.W843fs|NF1_uc010cso.2_Frame_Shift_Ins_p.W19fs	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1831_1832					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GGACCCGCTGGGAACTGTCACA	0.51			NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			29	124	---	---	---	---	NA	NA	NA	NA	NA
EHD2	30846	broad.mit.edu	37	19	48239761	48239761	+	Frame_Shift_Del	DEL	G	G	-			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr19:48239761delG	uc002phj.3	+	5	1301	c.1051delG	c.(1051-1053)GGGfs	p.G351fs	EHD2_uc010xyu.1_Frame_Shift_Del_p.G215fs|EHD2_uc010xyv.1_Frame_Shift_Del_p.G34fs	NM_014601	NP_055416	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	351					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			ovary(1)|skin(1)	2		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		CATCTCCCCTGGGGACTTTCC	0.527			NA											27	41	---	---	---	---	NA	NA	NA	NA	NA
C20orf132	140699	broad.mit.edu	37	20	35766357	35766357	+	Frame_Shift_Del	DEL	C	C	-			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr20:35766357delC	uc010zvu.1	-	15	1626	c.1535delG	c.(1534-1536)GGAfs	p.G512fs	C20orf132_uc002xgk.2_Frame_Shift_Del_p.G134fs|C20orf132_uc002xgm.2_Frame_Shift_Del_p.G512fs|C20orf132_uc002xgn.2_Frame_Shift_Del_p.G477fs	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	387											0		Myeloproliferative disorder(115;0.00878)				ACAGATAACTCCCATAATTTC	0.408			NA											12	16	---	---	---	---	NA	NA	NA	NA	NA
GNAZ	2781	broad.mit.edu	37	22	23438319	23438319	+	Frame_Shift_Del	DEL	A	A	-			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr22:23438319delA	uc002zwu.1	+	2	974	c.437delA	c.(436-438)GAGfs	p.E146fs	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	146						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		CGCTCCAGCGAGTACCACCTG	0.662			NA											7	54	---	---	---	---	NA	NA	NA	NA	NA
AP1B1	162	broad.mit.edu	37	22	29745310	29745311	+	Frame_Shift_Ins	INS	-	-	G			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr22:29745310_29745311insG	uc003afj.2	-	11	1517_1518	c.1333_1334insC	c.(1333-1335)CGGfs	p.R445fs	AP1B1_uc003afi.2_Frame_Shift_Ins_p.R445fs|AP1B1_uc003afk.2_Frame_Shift_Ins_p.R445fs|AP1B1_uc003afl.2_Frame_Shift_Ins_p.R445fs|AP1B1_uc011ako.1_5'UTR	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	445					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						CATGGCAGCCCGGGCCTCAGGC	0.584			NA											52	68	---	---	---	---	NA	NA	NA	NA	NA
OTOP1	133060	broad.mit.edu	37	4	4204225	4204229	+	Frame_Shift_Del	DEL	TTGAG	TTGAG	-			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	TTGAG	TTGAG	-	-	TTGAG	TTGAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:4204225_4204229delTTGAG	uc003ghp.1	-	4	706_710	c.676_680delCTCAA	c.(676-681)CTCAATfs	p.L226fs		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	226_227					biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CTTGTGCTCATTGAGTTGGTGCTTT	0.502			NA											7	170	---	---	---	---	NA	NA	NA	NA	NA
UNC5C	8633	broad.mit.edu	37	4	96090406	96090407	+	Frame_Shift_Ins	INS	-	-	CC			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr4:96090406_96090407insCC	uc003htp.1	-	16	2928_2929	c.2774_2775insGG	c.(2773-2775)TTAfs	p.L925fs	uc003hto.2_5'Flank	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	925	Cytoplasmic (Potential).|Death.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CTTCTGCTGCTAAGGACACCAC	0.51			NA											42	122	---	---	---	---	NA	NA	NA	NA	NA
DST	667	broad.mit.edu	37	6	56510720	56510720	+	Frame_Shift_Del	DEL	C	C	-			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr6:56510720delC	uc003pdf.2	-	14	1651	c.1623delG	c.(1621-1623)GGGfs	p.G541fs	DST_uc003pcz.3_Frame_Shift_Del_p.G363fs|DST_uc011dxj.1_Frame_Shift_Del_p.G392fs|DST_uc011dxk.1_Frame_Shift_Del_p.G403fs|DST_uc011dxl.1_Frame_Shift_Del_p.G392fs|DST_uc003pde.2_Frame_Shift_Del_p.G479fs	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	363					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TAATGAGTTTCCCCCACTCTT	0.418			NA											37	121	---	---	---	---	NA	NA	NA	NA	NA
STEAP2	261729	broad.mit.edu	37	7	89859319	89859319	+	Frame_Shift_Del	DEL	C	C	-			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr7:89859319delC	uc003ujz.2	+	4	1547	c.1154delC	c.(1153-1155)GCTfs	p.A385fs	STEAP2_uc010len.2_Frame_Shift_Del_p.A385fs|STEAP2_uc003uka.2_Frame_Shift_Del_p.A385fs|STEAP2_uc003ukb.2_Frame_Shift_Del_p.A385fs|STEAP2_uc003ukc.2_Frame_Shift_Del_p.A385fs|STEAP2_uc003ukd.2_Frame_Shift_Del_p.A385fs	NM_152999	NP_694544	Q8NFT2	STEA2_HUMAN	six transmembrane epithelial antigen of the	385	Ferric oxidoreductase.				electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			ovary(2)	2	all_hematologic(106;0.112)					GTGAGCAATGCTTTAAACTGG	0.398			NA											53	331	---	---	---	---	NA	NA	NA	NA	NA
CEL	1056	broad.mit.edu	37	9	135947097	135947098	+	Frame_Shift_Ins	INS	-	-	C			TCGA-49-6767-01A-11D-1855-08	TCGA-49-6767-11A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f82f494-042a-4f00-954c-4761fa25b298	25c0da49-0dd3-4eac-a262-756b8e3870dc	g.chr9:135947097_135947098insC	uc010naa.1	+	11	2233_2234	c.2217_2218insC	c.(2215-2220)GTGCCCfs	p.V739fs		NM_001807	NP_001798	P19835	CEL_HUMAN	carboxyl ester lipase precursor	736_737	17.|17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type).				cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		CTGCCCCTGTGCCCCCCACAGA	0.658			NA											8	20	---	---	---	---	NA	NA	NA	NA	NA
