Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC2A7	155184	broad.mit.edu	37	1	9064913	9064913	+	Silent	SNP	G	G	T	rs139989195		TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:9064913G>T	uc009vmo.1	-	11	1218	c.1218C>A	c.(1216-1218)ACC>ACA	p.T406T		NM_207420	NP_997303	Q6PXP3	GTR7_HUMAN	intestinal facilitative glucose transporter 7	406	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sugar transmembrane transporter activity				0	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.04e-07)|COAD - Colon adenocarcinoma(227;7.66e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		GGAAGATCTCGGTCCTCACCA	0.657			NA											5	18					0.000602214	0.000666385	0.000602	1	0
AADACL3	126767	broad.mit.edu	37	1	12785337	12785337	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:12785337G>A	uc009vnn.1	+	4	660	c.427G>A	c.(427-429)GCA>ACA	p.A143T	AADACL3_uc001aug.1_Missense_Mutation_p.A73T	NM_001103170	NP_001096640	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3 isoform 1	143							hydrolase activity				0	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		GGCAATAGCCGCAGTGGTTTG	0.567			NA											9	88					0	0	0.006214	0	0
LOC649330	649330	broad.mit.edu	37	1	12907473	12907473	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:12907473G>C	uc009vno.2	-	1	765	c.670C>G	c.(670-672)CAG>GAG	p.Q224E	HNRNPCL1_uc010obf.1_Missense_Mutation_p.Q224E	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	224							nucleic acid binding|nucleotide binding				0						CTACTGCTCTGCTCCTCTTCT	0.463			NA											17	140					0	0	0.010504	0	0
CASP9	842	broad.mit.edu	37	1	15834374	15834374	+	Silent	SNP	T	T	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:15834374T>A	uc001awn.2	-	3	542	c.447A>T	c.(445-447)GCA>GCT	p.A149A	CASP9_uc001awm.1_Silent_p.A149A|CASP9_uc001awo.2_Intron|CASP9_uc001awp.2_5'UTR|CASP9_uc009voi.2_5'UTR|CASP9_uc010obm.1_Silent_p.A66A|CASP9_uc001awq.2_Silent_p.A66A	NM_001229	NP_001220	P55211	CASP9_HUMAN	caspase 9 isoform alpha preproprotein	149					activation of caspase activity by cytochrome c|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol	cysteine-type endopeptidase activity|enzyme activator activity|protein binding			central_nervous_system(1)|kidney(1)	2		Breast(348;0.000207)|all_lung(284;0.000211)|Colorectal(325;0.000259)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;8.49e-07)|COAD - Colon adenocarcinoma(227;4.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00013)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00763)|READ - Rectum adenocarcinoma(331;0.0655)		TCACCAAATCTGCATTTCCCC	0.562			NA											6	68					0	0	0.00308	0	0
EPHB2	2048	broad.mit.edu	37	1	23219500	23219500	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:23219500C>T	uc009vqj.1	+	7	1697	c.1552C>T	c.(1552-1554)CGC>TGC	p.R518C	EPHB2_uc001bge.2_Missense_Mutation_p.R518C|EPHB2_uc001bgf.2_Missense_Mutation_p.R518C|EPHB2_uc010odu.1_Missense_Mutation_p.R518C	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	518	Fibronectin type-III 2.|Extracellular (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		AGGTTACGGGCGCTACAGCGG	0.577			NA							Hereditary_Prostate_Cancer				13	45					0	0	0.00245	0	0
EIF3I	8668	broad.mit.edu	37	1	32694336	32694336	+	Silent	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:32694336C>T	uc001bur.3	+	9	1181	c.648C>T	c.(646-648)GAC>GAT	p.D216D	EIF3I_uc009vuc.2_Silent_p.D216D|EIF3I_uc001bus.2_Silent_p.D168D	NM_003757	NP_003748	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3,	216	WD 4.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				AGCTTTTTGACTCCACAACTC	0.562	Colon(102;1138 2140 2180 17876)		NA											14	321					0	0	0.004007	0	0
DOCK7	85440	broad.mit.edu	37	1	62941485	62941485	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:62941485G>A	uc001daq.2	-	45	5855	c.5821C>T	c.(5821-5823)CGT>TGT	p.R1941C	DOCK7_uc001dan.2_Missense_Mutation_p.R1804C|DOCK7_uc001dao.2_Missense_Mutation_p.R1802C|DOCK7_uc001dap.2_Missense_Mutation_p.R1921C|DOCK7_uc001dam.2_Missense_Mutation_p.R1123C|DOCK7_uc010oov.1_Missense_Mutation_p.R682C|DOCK7_uc001dar.1_Missense_Mutation_p.R115C	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1952	DHR-2.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						CCATGGGCACGGCCATCTAAA	0.383			NA											25	108					0	0	0.005443	0	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77510030	77510030	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:77510030G>A	uc001dhi.2	+	3	578	c.403G>A	c.(403-405)GTG>ATG	p.V135M	ST6GALNAC5_uc010ori.1_Intron|ST6GALNAC5_uc009wbw.2_RNA	NM_030965	NP_112227	Q9BVH7	SIA7E_HUMAN	sialyltransferase 7E	135	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			pancreas(1)|skin(1)	2						TGGGCGTGACGTGGGCAATCG	0.617			NA											10	62					0	0	0.001855	0	0
BCL9	607	broad.mit.edu	37	1	147096156	147096156	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:147096156C>A	uc001epq.2	+	10	4417	c.3677C>A	c.(3676-3678)CCT>CAT	p.P1226H	BCL9_uc010ozr.1_Missense_Mutation_p.P1140H	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1226	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					GTCATCCGACCTGGAGCCACC	0.572			NA	T	IGH@|IGL@	B-ALL								9	83					1.08611e-07	1.35763e-07	0.010729	1	0
RXRG	6258	broad.mit.edu	37	1	165389184	165389184	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:165389184C>T	uc001gda.2	-	3	665	c.365G>A	c.(364-366)GGA>GAA	p.G122E		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	122	Modulating (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	GTTCATGTTTCCAATCCCGGG	0.493			NA											16	45					0	0	0.004007	0	0
TBX19	9095	broad.mit.edu	37	1	168260408	168260408	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:168260408C>T	uc001gfl.2	+	2	265	c.214C>T	c.(214-216)CCA>TCA	p.P72S	TBX19_uc001gfj.3_Missense_Mutation_p.P3S	NM_005149	NP_005140	O60806	TBX19_HUMAN	T-box 19	72	T-box.				anatomical structure morphogenesis	nucleus	DNA binding				0	all_hematologic(923;0.215)					ACGGATGTTTCCAGTCCTAAA	0.517			NA											30	152					0	0	0.013726	0	0
METTL13	51603	broad.mit.edu	37	1	171753362	171753362	+	Silent	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:171753362C>T	uc001ghz.2	+	2	983	c.636C>T	c.(634-636)TTC>TTT	p.F212F	METTL13_uc001gia.2_Silent_p.F126F|METTL13_uc001gib.2_Intron|METTL13_uc010pml.1_Silent_p.F211F	NM_015935	NP_057019	Q8N6R0	MTL13_HUMAN	CGI-01 protein isoform 1	212							methyltransferase activity|protein binding			kidney(1)	1						TGACCAAGTTCAGGCCAGTCC	0.612			NA											21	80					0	0	0.012319	0	0
KLHL20	27252	broad.mit.edu	37	1	173751319	173751319	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:173751319A>G	uc001gjc.2	+	11	1875	c.1696A>G	c.(1696-1698)ACA>GCA	p.T566A	KLHL20_uc010pmr.1_Missense_Mutation_p.T377A|KLHL20_uc009wwf.2_Missense_Mutation_p.T548A	NM_014458	NP_055273	Q9Y2M5	KLH20_HUMAN	kelch-like 20	566	Kelch 6.				cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			ovary(1)	1						TGATGGCACAACATACTTGAA	0.413	GBM(159;862 2695 6559 23041)		NA											4	114					0	0	0.009096	0	0
RC3H1	149041	broad.mit.edu	37	1	173931109	173931109	+	Silent	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:173931109G>A	uc001gju.3	-	11	2043	c.1956C>T	c.(1954-1956)AAC>AAT	p.N652N	RC3H1_uc010pms.1_Silent_p.N652N|RC3H1_uc001gjv.2_Silent_p.N652N|RC3H1_uc010pmt.1_Silent_p.N652N	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	652	Pro-rich.				cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CATACTGAGAGTTTACAACAC	0.512			NA											5	81					0	0	0.000602	0	0
PPP1R15B	84919	broad.mit.edu	37	1	204379080	204379080	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:204379080T>C	uc001hav.3	-	1	1865	c.1460A>G	c.(1459-1461)TAT>TGT	p.Y487C		NM_032833	NP_116222	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	487					regulation of translation					ovary(1)|pancreas(1)	2	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			CTGGGGATTATAAGGATCTAC	0.438			NA											22	80					0	0	0.010504	0	0
KCNK2	3776	broad.mit.edu	37	1	215259895	215259895	+	Silent	SNP	C	C	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:215259895C>A	uc001hkq.2	+	2	400	c.231C>A	c.(229-231)GCC>GCA	p.A77A	KCNK2_uc001hko.2_Silent_p.A73A|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Silent_p.A62A	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	77	Helical; (Potential).						outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	TCATCGGAGCCACCGTGTTCA	0.468			NA											12	69					6.40141e-05	7.2621e-05	0.010729	1	0
CAPN9	10753	broad.mit.edu	37	1	230895275	230895275	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:230895275G>A	uc001htz.1	+	3	414	c.301G>A	c.(301-303)GCC>ACC	p.A101T	CAPN9_uc009xfg.1_Intron|CAPN9_uc001hua.1_Missense_Mutation_p.A101T	NM_006615	NP_006606	O14815	CAN9_HUMAN	calpain 9 isoform 1	101	Calpain catalytic.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				CTGGCTATTAGCCGCCATCGC	0.478			NA											7	45					0	0	0.001984	0	0
RBM34	23029	broad.mit.edu	37	1	235295187	235295187	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:235295187C>A	uc001hwn.2	-	11	1164	c.1134G>T	c.(1132-1134)AAG>AAT	p.K378N	TOMM20_uc001hwl.2_5'Flank|RBM34_uc001hwo.2_RNA|ARID4B_uc001hwp.2_RNA	NM_015014	NP_055829	P42696	RBM34_HUMAN	RNA binding motif protein 34 isoform 1	378						nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			TACTGACATTCTTCAATCGTG	0.318			NA											14	59					7.93312e-07	9.7361e-07	0.00245	1	0
NLRP3	114548	broad.mit.edu	37	1	247588207	247588207	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr1:247588207G>A	uc001icr.2	+	5	1600	c.1462G>A	c.(1462-1464)GAC>AAC	p.D488N	NLRP3_uc001ics.2_Missense_Mutation_p.D488N|NLRP3_uc001icu.2_Missense_Mutation_p.D488N|NLRP3_uc001icw.2_Missense_Mutation_p.D488N|NLRP3_uc001icv.2_Missense_Mutation_p.D488N|NLRP3_uc010pyw.1_Missense_Mutation_p.D486N|NLRP3_uc001ict.1_Missense_Mutation_p.D486N	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	488	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TGAGGAGTCCGACCTCAGGAA	0.552			NA											5	25					0	0	0.001168	0	0
ATP5C1	509	broad.mit.edu	37	10	7842009	7842009	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr10:7842009A>T	uc001iju.2	+	6	670	c.592A>T	c.(592-594)ACA>TCA	p.T198S	ATP5C1_uc009xiq.1_Missense_Mutation_p.T198S|ATP5C1_uc010qbc.1_Missense_Mutation_p.T149S|ATP5C1_uc001ijv.2_Missense_Mutation_p.T198S	NM_001001973	NP_001001973	P36542	ATPG_HUMAN	ATP synthase, H+ transporting, mitochondrial F1	198					oxidative phosphorylation|respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0						CTCCTATAAGACAGAAGAAAA	0.299	Melanoma(143;1012 1820 16249 30920 33158)		NA											28	131					0	0	0.008361	0	0
ITGA8	8516	broad.mit.edu	37	10	15714661	15714661	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr10:15714661G>T	uc001ioc.1	-	7	764	c.764C>A	c.(763-765)ACG>AAG	p.T255K	ITGA8_uc010qcb.1_Missense_Mutation_p.T255K	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	255	Extracellular (Potential).|FG-GAP 4.				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						AGCCACTTCCGTCTGCTTTTC	0.418			NA											24	112					1.39806e-14	1.90644e-14	0.008361	1	0
C10orf68	79741	broad.mit.edu	37	10	33015700	33015700	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr10:33015700G>T	uc001iwn.3	+	8	1002	c.529G>T	c.(529-531)GTG>TTG	p.V177L	C10orf68_uc001iwl.1_Missense_Mutation_p.V185L|C10orf68_uc001iwm.1_Missense_Mutation_p.V153L|C10orf68_uc010qei.1_Missense_Mutation_p.V104L|C10orf68_uc001iwo.3_5'Flank	NM_024688	NP_078964	Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	177										skin(2)|ovary(1)	3						TCAAGATTCAGTGTCAAAACT	0.284			NA											6	14					0.00198382	0.00214252	0.001984	1	0
ANKRD30A	91074	broad.mit.edu	37	10	37438705	37438705	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr10:37438705C>A	uc001iza.1	+	11	1504	c.1405C>A	c.(1405-1407)CCT>ACT	p.P469T		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	525						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CCCCATTTAGCCTGCCATTGA	0.279			NA											10	65					2.17888e-05	2.55781e-05	0.006214	1	0
P4HA1	5033	broad.mit.edu	37	10	74810876	74810876	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr10:74810876C>A	uc010qka.1	-	8	1169	c.835G>T	c.(835-837)GCT>TCT	p.A279S	P4HA1_uc001jtg.2_Missense_Mutation_p.A279S|P4HA1_uc001jth.2_Missense_Mutation_p.A279S|P4HA1_uc010qkb.1_Missense_Mutation_p.A279S|P4HA1_uc001jti.2_RNA	NM_001142595	NP_001136067	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha I subunit isoform 2	279						endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			ovary(1)	1	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TAATCCACAGCAACCCCTTTT	0.358	Colon(147;367 2405 2662 52127)		NA											34	184					4.92203e-23	6.9216e-23	0.00623	1	0
LRIT1	26103	broad.mit.edu	37	10	85993891	85993891	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr10:85993891G>A	uc001kcz.1	-	3	855	c.833C>T	c.(832-834)ACT>ATT	p.T278I		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	278	Lumenal (Potential).|Ig-like C2-type.					integral to endoplasmic reticulum membrane					0						AGGGACTCCAGTAGCTCCACA	0.592			NA											12	69					0	0	0.010729	0	0
CALHM1	255022	broad.mit.edu	37	10	105218098	105218098	+	Silent	SNP	T	T	G			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr10:105218098T>G	uc001kxe.2	-	1	551	c.411A>C	c.(409-411)GCA>GCC	p.A137A		NM_001001412	NP_001001412	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	137						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			ovary(1)	1						CGTTGCCCAGTGCGCTCACGG	0.701			NA											9	23					0	0	0.006214	0	0
C10orf79	80217	broad.mit.edu	37	10	105890011	105890011	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr10:105890011C>T	uc001kxw.2	-	38	5000	c.4884G>A	c.(4882-4884)ATG>ATA	p.M1628I	C10orf79_uc009xxq.2_Missense_Mutation_p.M907I	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	1628											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		TCTGCTGTTGCATCATGTTTT	0.313			NA											11	48					0	0	0.010729	0	0
ATRNL1	26033	broad.mit.edu	37	10	117093795	117093795	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr10:117093795G>C	uc001lcg.2	+	19	3427	c.3041G>C	c.(3040-3042)TGC>TCC	p.C1014S	ATRNL1_uc010qsm.1_Intron|ATRNL1_uc010qsn.1_Intron	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	1014	Laminin EGF-like 1.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		CCTTTAGCTTGCCAGTGTAAT	0.328			NA											3	42					0	0	0.004672	0	0
OR52N2	390077	broad.mit.edu	37	11	5842280	5842280	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr11:5842280G>A	uc010qzp.1	+	1	715	c.715G>A	c.(715-717)GCC>ACC	p.A239T	TRIM5_uc001mbq.1_Intron	NM_001005174	NP_001005174	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N,	239	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCGTCACAAAGCCTTCAGCAC	0.423			NA											10	124					0	0	0.006214	0	0
CNGA4	1262	broad.mit.edu	37	11	6262815	6262815	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr11:6262815G>T	uc001mco.2	+	5	1179	c.1072G>T	c.(1072-1074)GAG>TAG	p.E358*	CNGA4_uc010raa.1_Nonsense_Mutation_p.E127*|CNGA4_uc001mcn.2_Nonsense_Mutation_p.E318*	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	358	cNMP.|Cytoplasmic (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGCCTGCTGGAGGAGCTGGT	0.582			NA											10	68					0.00829132	0.00867696	0.008291	1	0
ACCSL	390110	broad.mit.edu	37	11	44080129	44080129	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr11:44080129C>T	uc001mxw.1	+	13	1560	c.1504C>T	c.(1504-1506)CTC>TTC	p.L502F	ACCSL_uc009ykr.2_Missense_Mutation_p.L321F	NM_001031854	NP_001027025	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase	502							1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(5)	5						AGAAGAACGGCTCCTCTATTG	0.522			NA											19	109					0	0	0.007413	0	0
PRDM11	56981	broad.mit.edu	37	11	45246107	45246107	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr11:45246107G>T	uc001myo.2	+	8	1433	c.1184G>T	c.(1183-1185)GGG>GTG	p.G395V		NM_020229	NP_064614	Q9NQV5	PRD11_HUMAN	PR domain containing 11	395										upper_aerodigestive_tract(1)	1						CAGACCCAGGGGGAGGGGGAC	0.562	NSCLC(118;1511 1736 6472 36603 43224)		NA											25	110					4.72057e-08	5.95586e-08	0.003954	1	0
C11orf9	745	broad.mit.edu	37	11	61548502	61548502	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr11:61548502C>A	uc001nsc.1	+	20	2653	c.2557C>A	c.(2557-2559)CCC>ACC	p.P853T	C11orf9_uc001nse.1_Missense_Mutation_p.P818T|C11orf9_uc010rll.1_Missense_Mutation_p.P244T	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	853					central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						AGGCATACAGCCCTCTTTGCT	0.617			NA											14	37					1.49906e-05	1.7752e-05	0.00245	1	0
FOLR1	2348	broad.mit.edu	37	11	71906939	71906939	+	Splice_Site	SNP	A	A	C			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr11:71906939A>C	uc001orz.1	+	6	632	c.494_splice	c.e6-2	p.G165_splice	FOLR1_uc001osa.1_Splice_Site_p.G165_splice|FOLR1_uc001osb.1_Splice_Site_p.G165_splice|FOLR1_uc001osc.1_Splice_Site_p.G165_splice|FOLR1_uc001osd.1_Splice_Site_p.G165_splice	NM_016724	NP_057936	P15328	FOLR1_HUMAN	folate receptor 1 precursor						cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			ovary(1)	1						TCCTCTCTACAGGGTTTAACA	0.517			NA											17	73					0	0	0.007413	0	0
ME3	10873	broad.mit.edu	37	11	86267641	86267641	+	Missense_Mutation	SNP	C	C	T	rs150824447	byFrequency	TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr11:86267641C>T	uc001pbz.2	-	3	675	c.421G>A	c.(421-423)GTG>ATG	p.V141M	ME3_uc001pca.2_Missense_Mutation_p.V141M|ME3_uc009yvk.2_Missense_Mutation_p.V141M|ME3_uc010rtr.1_RNA	NM_001014811	NP_001014811	Q16798	MAON_HUMAN	mitochondrial malic enzyme 3 precursor	141					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			ovary(1)	1		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	GCCAGCCCCACGGTAGGCGTG	0.592			NA											5	29					0	0	0.000602	0	0
KCNA1	3736	broad.mit.edu	37	12	5021088	5021088	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr12:5021088G>A	uc001qnh.2	+	2	1649	c.544G>A	c.(544-546)GTC>ATC	p.V182I		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	182	Helical; Name=Segment S1; (Potential).				synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CATCTCCATCGTCATCTTTTG	0.597			NA											10	46					0	0	0.008291	0	0
OVCH1	341350	broad.mit.edu	37	12	29624866	29624866	+	Silent	SNP	G	G	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr12:29624866G>T	uc001rix.1	-	16	1725	c.1725C>A	c.(1723-1725)ATC>ATA	p.I575I		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	575	Peptidase S1 2.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					CCCCTCCTGCGATTCTTCTGG	0.502			NA											6	7					0.00198382	0.00214252	0.001984	1	0
KRT80	144501	broad.mit.edu	37	12	52567409	52567409	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr12:52567409T>G	uc001rzx.2	-	5	904	c.806A>C	c.(805-807)GAG>GCG	p.E269A	KRT80_uc001rzw.2_Missense_Mutation_p.E304A|KRT80_uc001rzy.2_Missense_Mutation_p.E269A	NM_182507	NP_872313	Q6KB66	K2C80_HUMAN	keratin 80 isoform a	269	Rod.|Coil 2.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.108)		TGCCTCGGCCTCCTCCAGGCT	0.657	GBM(178;2309 2916 15678 35873)		NA											12	51					0	0	0.013537	0	0
KCNC2	3747	broad.mit.edu	37	12	75444672	75444672	+	Silent	SNP	A	A	C			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr12:75444672A>C	uc001sxg.1	-	3	1657	c.1113T>G	c.(1111-1113)CTT>CTG	p.L371L	KCNC2_uc009zry.2_Silent_p.L371L|KCNC2_uc001sxe.2_Silent_p.L371L|KCNC2_uc001sxf.2_Silent_p.L371L|KCNC2_uc010stw.1_Silent_p.L371L	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	371	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						GAGTATGTCCAAGCACCCTCA	0.438			NA											8	32					0	0	0.010729	0	0
NAV3	89795	broad.mit.edu	37	12	78513025	78513025	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr12:78513025G>A	uc001syp.2	+	15	3222	c.3049G>A	c.(3049-3051)GAT>AAT	p.D1017N	NAV3_uc001syo.2_Missense_Mutation_p.D1017N|NAV3_uc010sub.1_Missense_Mutation_p.D517N|NAV3_uc009zsf.2_Missense_Mutation_p.D25N	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1017						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AGGGAAAACCGATGATGCCAA	0.388			NA								HNSCC(70;0.22)			27	88					0	0	0.007291	0	0
LUM	4060	broad.mit.edu	37	12	91502247	91502247	+	Silent	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr12:91502247C>T	uc001tbm.2	-	2	899	c.510G>A	c.(508-510)CGG>CGA	p.R170R	LUM_uc001tbn.2_Intron	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	170	LRR 5.				collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)	2						CCTCTTTCAGCCGATTGTGCT	0.448			NA											5	76					0	0	0.000602	0	0
SBNO1	55206	broad.mit.edu	37	12	123801796	123801796	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr12:123801796C>G	uc010tap.1	-	20	2907	c.2907G>C	c.(2905-2907)TGG>TGC	p.W969C	SBNO1_uc010tao.1_Missense_Mutation_p.W968C|SBNO1_uc010taq.1_Intron|SBNO1_uc001ues.1_5'Flank	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	969							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TATCAGCGCTCCAAGGTAATT	0.403			NA											15	58					0	0	0.00245	0	0
POTEG	404785	broad.mit.edu	37	14	19553826	19553826	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr14:19553826G>A	uc001vuz.1	+	1	462	c.410G>A	c.(409-411)CGA>CAA	p.R137Q	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	137										ovary(1)	1						CACGTCCGTCGAGAAGATCTG	0.577			NA											4	105					0	0	0.001168	0	0
ACTR10	55860	broad.mit.edu	37	14	58701086	58701086	+	Splice_Site	SNP	A	A	T	rs35928266		TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr14:58701086A>T	uc001xdf.2	+	13	1176	c.1073_splice	c.e13-2	p.G358_splice	C14orf37_uc010tro.1_Intron|ACTR10_uc001xdg.2_Splice_Site_p.G160_splice|ACTR10_uc001xdh.2_Splice_Site_p.G160_splice|ACTR10_uc010trp.1_Splice_Site|ACTR10_uc010apc.2_Splice_Site_p.G148_splice	NM_018477	NP_060947	Q9NZ32	ARP10_HUMAN	uncharacterized hypothalamus protein HARP11							cytoplasm				central_nervous_system(1)	1						TTTGTCACACAGGGGCTATTT	0.353			NA											3	69					0	0	0.004672	0	0
SERPINA5	5104	broad.mit.edu	37	14	95056618	95056618	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr14:95056618T>A	uc001ydm.2	+	4	1070	c.860T>A	c.(859-861)CTG>CAG	p.L287Q	SERPINA5_uc010ave.2_Missense_Mutation_p.L287Q|SERPINA3_uc001ydo.3_5'Flank	NM_000624	NP_000615	P05154	IPSP_HUMAN	serine (or cysteine) proteinase inhibitor, clade	287					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(2)	2				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	GAGAAAACGCTGAGGAAGTGG	0.552			NA											6	9					0	0	0.001984	0	0
SPPL2A	84888	broad.mit.edu	37	15	51040396	51040396	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr15:51040396G>C	uc001zyv.2	-	4	544	c.364C>G	c.(364-366)CCT>GCT	p.P122A		NM_032802	NP_116191	Q8TCT8	PSL2_HUMAN	signal peptide peptidase-like 2A	122	Cytoplasmic (Potential).|PA.					integral to membrane	aspartic-type endopeptidase activity				0				all cancers(107;0.000712)|GBM - Glioblastoma multiforme(94;0.00314)		CCTGAGGGAGGAAACTAAAAA	0.249	Melanoma(50;790 1209 4069 22965 33125)		NA											3	9					0	0	0.004672	0	0
RASGRF1	5923	broad.mit.edu	37	15	79288097	79288097	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr15:79288097C>A	uc002beq.2	-	21	3435	c.3060G>T	c.(3058-3060)GAG>GAT	p.E1020D	RASGRF1_uc002bep.2_Missense_Mutation_p.E1004D|RASGRF1_uc010blm.1_Missense_Mutation_p.E929D|RASGRF1_uc002ber.3_Missense_Mutation_p.E1004D|RASGRF1_uc010unh.1_Missense_Mutation_p.E415D|RASGRF1_uc002beo.2_Missense_Mutation_p.E236D	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	1022					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						GCGTGATCTCCTCCAGCGTGA	0.627			NA											4	77					0.00909568	0.00944551	0.009096	1	0
FAM154B	283726	broad.mit.edu	37	15	82574861	82574861	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr15:82574861C>A	uc002bgv.2	+	3	724	c.655C>A	c.(655-657)CGT>AGT	p.R219S	FAM154B_uc010unr.1_Missense_Mutation_p.R204S|FAM154B_uc010uns.1_RNA	NM_001008226	NP_001008227	Q658L1	F154B_HUMAN	hypothetical protein LOC283726	219										skin(2)	2						CACTGAATTCCGTGAAAGTTT	0.473			NA											8	32					0.00448238	0.00472751	0.004482	1	0
SLC5A2	6524	broad.mit.edu	37	16	31500054	31500054	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr16:31500054G>A	uc002ecf.3	+	10	1260	c.1241G>A	c.(1240-1242)CGG>CAG	p.R414Q	SLC5A2_uc010car.2_Intron|C16orf58_uc002ecg.2_RNA	NM_003041	NP_003032	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose	414	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			ovary(1)	1						ACGCGCCTGCGGCCACGCGCC	0.701			NA											6	10					0	0	0.001984	0	0
Unknown	0	broad.mit.edu	37	16	90161578	90161578	+	Silent	SNP	G	G	A	rs13337896	by1000genomes	TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr16:90161578G>A	uc002fqp.2	+	3	931	c.453G>A	c.(451-453)ACG>ACA	p.T151T	uc002fqq.2_Silent_p.T168T					Homo sapiens, Similar to tubulin, beta, 2, clone IMAGE:4873024, mRNA.												NA						GCCAAGGGACGCTACACCGAA	0.587			NA											3	26					0	0	0.004672	0	0
TP53	7157	broad.mit.edu	37	17	7578203	7578203	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr17:7578203C>T	uc002gim.2	-	6	840	c.646G>A	c.(646-648)GTG>ATG	p.V216M	TP53_uc002gig.1_Missense_Mutation_p.V216M|TP53_uc002gih.2_Missense_Mutation_p.V216M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V84M|TP53_uc010cng.1_Missense_Mutation_p.V84M|TP53_uc002gii.1_Missense_Mutation_p.V84M|TP53_uc010cnh.1_Missense_Mutation_p.V216M|TP53_uc010cni.1_Missense_Mutation_p.V216M|TP53_uc002gij.2_Missense_Mutation_p.V216M|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.V123M|TP53_uc002gio.2_Missense_Mutation_p.V84M|TP53_uc010vug.1_Missense_Mutation_p.V177M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	216	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> A (in sporadic cancers; somatic mutation).|V -> E (in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|V -> M (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V216M(49)|p.V216del(8)|p.0?(7)|p.V216L(7)|p.V216E(4)|p.V216G(3)|p.V216A(3)|p.V216fs*6(2)|p.V216fs*31(2)|p.H214fs*5(2)|p.K164_P219del(1)|p.V216fs*32(1)|p.V216fs*33(1)|p.S215fs*27(1)|p.S215fs*29(1)|p.V216fs*5(1)|p.V216_Y220delVVVPY(1)|p.D208_V216delDRNTFRHSV(1)|p.D208fs*1(1)|p.V216fs*28(1)|p.S215fs*31(1)|p.S215_V216insX(1)|p.T211fs*28(1)|p.D207_V216del10(1)|p.S215_V218>R(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACCACCACACTATGTCGA	0.537	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			3	16					0	0	0.009096	0	0
MYH2	4620	broad.mit.edu	37	17	10428126	10428126	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr17:10428126C>A	uc010coi.2	-	34	5047	c.4919G>T	c.(4918-4920)CGC>CTC	p.R1640L	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R1640L|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1640	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						AGCAGCCATGCGGTTGGCATG	0.512			NA											18	73					1.45105e-14	1.95892e-14	0.006122	1	0
ENPP7	339221	broad.mit.edu	37	17	77709193	77709193	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr17:77709193A>T	uc002jxa.2	+	3	771	c.751A>T	c.(751-753)ACC>TCC	p.T251S		NM_178543	NP_848638	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	251					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			central_nervous_system(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CGGCATGACGACCGTGGACAA	0.607			NA											34	50					0	0	0.004289	0	0
DSG2	1829	broad.mit.edu	37	18	29126289	29126289	+	Silent	SNP	T	T	C			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr18:29126289T>C	uc002kwu.3	+	15	3128	c.2940T>C	c.(2938-2940)GCT>GCC	p.A980A	uc002kwv.3_Intron	NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	980	Desmoglein repeat 4.|Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			AGCCTTATGCTAATGAAGGTA	0.498			NA											18	36					0	0	0.00499	0	0
NETO1	81832	broad.mit.edu	37	18	70461611	70461611	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr18:70461611C>G	uc002lkw.2	-	5	782	c.498G>C	c.(496-498)TTG>TTC	p.L166F	NETO1_uc002lkx.1_Missense_Mutation_p.L165F|NETO1_uc002lky.1_Missense_Mutation_p.L166F	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	166	Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GTAATGGTTTCAAAGCTCCAA	0.303			NA											16	82					0	0	0.004007	0	0
ZNF709	163051	broad.mit.edu	37	19	12575444	12575444	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr19:12575444C>A	uc002mtv.3	-	4	1453	c.1292G>T	c.(1291-1293)TGT>TTT	p.C431F	ZNF709_uc002mtw.3_Missense_Mutation_p.C399F|ZNF709_uc002mtx.3_Missense_Mutation_p.C431F	NM_152601	NP_689814	Q8N972	ZN709_HUMAN	zinc finger protein 709 isoform a	431	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGAACTGGAACAACTGAAGGC	0.423	GBM(33;565 669 12371 29134 51667)		NA											18	150					9.16793e-09	1.17873e-08	0.00499	1	0
FFAR3	2865	broad.mit.edu	37	19	35849909	35849909	+	Silent	SNP	C	C	T	rs148149328		TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr19:35849909C>T	uc002nzd.2	+	2	192	c.117C>T	c.(115-117)TTC>TTT	p.F39F	FFAR3_uc010xsu.1_RNA	NM_005304	NP_005295	O14843	FFAR3_HUMAN	free fatty acid receptor 3	39	Helical; Name=1; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding				0	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			TGGTGGTCTTCGTGGGCAAGC	0.637	Esophageal Squamous(185;1742 2042 21963 24215 27871)		NA											9	96					0	0	0.013537	0	0
RYR1	6261	broad.mit.edu	37	19	38934235	38934235	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr19:38934235G>A	uc002oit.2	+	4	438	c.308G>A	c.(307-309)GGC>GAC	p.G103D	RYR1_uc002oiu.2_Missense_Mutation_p.G103D	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	103	Cytoplasmic.|MIR 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTCCTGTATGGCCATGCCATC	0.652			NA											5	31					0	0	0.000602	0	0
PSG8	440533	broad.mit.edu	37	19	43268074	43268074	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr19:43268074A>T	uc002ouo.2	-	2	522	c.424T>A	c.(424-426)TTA>ATA	p.L142I	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc002oui.2_Intron|PSG8_uc002ouh.2_Missense_Mutation_p.L142I|PSG8_uc010ein.2_Intron|PSG8_uc002ouj.3_Missense_Mutation_p.L17I|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Missense_Mutation_p.L142I|PSG8_uc002oum.3_Missense_Mutation_p.L142I|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.L142I	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	142	Ig-like V-type.					extracellular region					0		Prostate(69;0.00899)				TCACGATATAAGGTGAAGGTG	0.493			NA											6	210					0	0	0.001984	0	0
KLK12	43849	broad.mit.edu	37	19	51532662	51532662	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr19:51532662A>G	uc002pvg.1	-	5	763	c.643T>C	c.(643-645)TCC>CCC	p.S215P	KLK11_uc002pvd.1_5'Flank|KLK11_uc002pve.1_5'Flank|KLK11_uc002pvf.1_5'Flank|KLK11_uc002pvc.3_5'Flank|KLK11_uc010eom.2_5'Flank|KLK12_uc010ycp.1_RNA|KLK12_uc010ycq.1_Missense_Mutation_p.S105P|KLK12_uc010ycr.1_Missense_Mutation_p.S105P|KLK12_uc010ycs.1_Missense_Mutation_p.S105P|KLK12_uc002pvh.1_Missense_Mutation_p.S215P|KLK12_uc002pvi.1_Missense_Mutation_p.S215P|KLK12_uc002pvj.1_3'UTR	NM_145894	NP_665901	Q9UKR0	KLK12_HUMAN	kallikrein 12 isoform 2	215	Peptidase S1.				proteolysis	extracellular region|soluble fraction	serine-type endopeptidase activity			ovary(1)	1		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00399)		GACCCCCAGGACACCAGACCT	0.532			NA											6	58					0	0	0.001168	0	0
ZNF813	126017	broad.mit.edu	37	19	53994017	53994017	+	Silent	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr19:53994017C>T	uc002qbu.2	+	4	659	c.531C>T	c.(529-531)TCC>TCT	p.S177S	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	177					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		TTTCAACATCCCAAAGAATTT	0.393			NA											26	116					0	0	0.00333	0	0
ZIM2	23619	broad.mit.edu	37	19	57286129	57286129	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr19:57286129C>A	uc002qnr.2	-	11	1893	c.1511G>T	c.(1510-1512)GGC>GTC	p.G504V	uc010ygp.1_Intron|uc002qnp.1_Intron|ZIM2_uc010ygq.1_Missense_Mutation_p.G300V|ZIM2_uc010ygr.1_Missense_Mutation_p.G300V|ZIM2_uc002qnq.2_Missense_Mutation_p.G504V|ZIM2_uc010etp.2_Missense_Mutation_p.G504V|ZIM2_uc010ygs.1_Missense_Mutation_p.G504V	NM_015363	NP_056178	Q9NZV7	ZIM2_HUMAN	zinc finger, imprinted 2	504	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		TGAGGGTCGGCCGAAACATTT	0.438			NA											8	46					0.000157383	0.000175593	0.00308	1	0
KIDINS220	57498	broad.mit.edu	37	2	8890421	8890421	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr2:8890421A>T	uc002qzc.2	-	24	3417	c.3235T>A	c.(3235-3237)TAC>AAC	p.Y1079N	KIDINS220_uc010yiv.1_Missense_Mutation_p.Y845N|KIDINS220_uc002qzd.2_Missense_Mutation_p.Y1037N|KIDINS220_uc010yiw.1_Missense_Mutation_p.Y1080N|KIDINS220_uc002qzb.2_5'UTR|KIDINS220_uc002qze.2_Missense_Mutation_p.Y84N	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1079	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					AGCGGGGGGTACGCCAGTCCT	0.562			NA											13	43					0	0	0.00245	0	0
LTBP1	4052	broad.mit.edu	37	2	33246130	33246130	+	Silent	SNP	C	C	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr2:33246130C>A	uc002ros.2	+	3	720	c.720C>A	c.(718-720)TCC>TCA	p.S240S		NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	240					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GGGCTGCTTCCTCGTGGGGCC	0.557			NA											16	149					1.5739e-10	2.0831e-10	0.004007	1	0
SOS1	6654	broad.mit.edu	37	2	39281778	39281778	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr2:39281778T>A	uc002rrk.3	-	5	738	c.697A>T	c.(697-699)AAT>TAT	p.N233Y	SOS1_uc010ynr.1_RNA|SOS1_uc002rrl.2_5'Flank	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	233	DH.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity	p.N233Y(1)		ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				AATTTTGAATTGGAGACAAAG	0.299			NA							Noonan_syndrome				4	52					0	0	0.009096	0	0
IL18RAP	8807	broad.mit.edu	37	2	103061650	103061650	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr2:103061650A>G	uc002tbx.2	+	9	1406	c.922A>G	c.(922-924)ATT>GTT	p.I308V	IL18RAP_uc010fiz.2_Missense_Mutation_p.I166V	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	308	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						CTTTCTCAGTATTAAATCCAC	0.378			NA											6	30					0	0	0.00308	0	0
RGPD4	285190	broad.mit.edu	37	2	108488193	108488193	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr2:108488193C>A	uc010ywk.1	+	20	3815	c.3733C>A	c.(3733-3735)CCC>ACC	p.P1245T	RGPD4_uc002tdu.2_Missense_Mutation_p.P432T|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1245					intracellular transport		binding			skin(2)	2						AAACACTGGGCCCACATTAGA	0.448			NA											14	291					2.31682e-05	2.6963e-05	0.003163	1	0
CKAP2L	150468	broad.mit.edu	37	2	113500284	113500284	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr2:113500284T>A	uc002tie.2	-	7	1900	c.1821A>T	c.(1819-1821)GAA>GAT	p.E607D	CKAP2L_uc002tif.2_Missense_Mutation_p.E196D|CKAP2L_uc010yxp.1_Missense_Mutation_p.E442D|uc002tid.2_3'UTR	NM_152515	NP_689728	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	607						centrosome					0						TAATAGTACCTTCTGTGGTTC	0.333			NA											13	26					0	0	0.001855	0	0
FAM123C	205147	broad.mit.edu	37	2	131520541	131520541	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr2:131520541C>T	uc002trw.2	+	2	1086	c.896C>T	c.(895-897)GCC>GTC	p.A299V	FAM123C_uc010fmv.2_Missense_Mutation_p.A299V|FAM123C_uc010fms.1_Missense_Mutation_p.A299V|FAM123C_uc010fmt.1_Missense_Mutation_p.A299V|FAM123C_uc010fmu.1_Missense_Mutation_p.A299V	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	299										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		GCCTCGCCCGCCCAGAATGAA	0.662			NA											10	43					0	0	0.006214	0	0
THSD7B	80731	broad.mit.edu	37	2	138414680	138414680	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr2:138414680A>G	uc002tva.1	+	23	4238	c.4238A>G	c.(4237-4239)AAT>AGT	p.N1413S	THSD7B_uc010zbj.1_RNA	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CTTTGGAACAATAACGAACGA	0.413			NA											8	49					0	0	0.006214	0	0
XIRP2	129446	broad.mit.edu	37	2	168103381	168103381	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr2:168103381A>G	uc002udx.2	+	8	5497	c.5479A>G	c.(5479-5481)ACA>GCA	p.T1827A	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.T1652A|XIRP2_uc010fpq.2_Missense_Mutation_p.T1605A|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1652					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GCCTCAGAGTACATTTGGTAA	0.408			NA											5	63					0	0	0.001168	0	0
XIRP2	129446	broad.mit.edu	37	2	168104724	168104724	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr2:168104724C>G	uc002udx.2	+	8	6840	c.6822C>G	c.(6820-6822)ATC>ATG	p.I2274M	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.I2099M|XIRP2_uc010fpq.2_Missense_Mutation_p.I2052M|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2099					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TGAATCCAATCAACTTTAACC	0.418			NA											10	38					0	0	0.008291	0	0
PLCL1	5334	broad.mit.edu	37	2	198948501	198948501	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr2:198948501G>A	uc010fsp.2	+	2	551	c.260G>A	c.(259-261)TGT>TAT	p.C87Y	PLCL1_uc002uuv.3_Missense_Mutation_p.C8Y	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	87	Interaction with PPP1C.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	AACCAAAAATGTGGTGGAAGA	0.318			NA											4	28					0	0	0.009096	0	0
EPHA4	2043	broad.mit.edu	37	2	222307631	222307631	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr2:222307631C>A	uc002vmq.2	-	11	2034	c.1992G>T	c.(1990-1992)AGG>AGT	p.R664S	EPHA4_uc002vmr.2_Missense_Mutation_p.R664S|EPHA4_uc010zlm.1_Missense_Mutation_p.R605S|EPHA4_uc010zln.1_Missense_Mutation_p.R664S	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	664	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		GGAAGTCTCTCCTCTGTTTGT	0.498			NA											7	98					0.00307968	0.00327367	0.00308	1	0
C20orf196	149840	broad.mit.edu	37	20	5843983	5843983	+	Silent	SNP	C	C	A	rs138963473		TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr20:5843983C>A	uc002wmf.2	+	3	579	c.492C>A	c.(490-492)TCC>TCA	p.S164S		NM_152504	NP_689717	Q8IYI0	CT196_HUMAN	hypothetical protein LOC149840	164											0						AGAGGCATTCCAGGGACACCC	0.507			NA											12	65					1.61879e-10	2.12172e-10	0.013537	1	0
FRG1B	284802	broad.mit.edu	37	20	29625892	29625892	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr20:29625892T>C	uc010ztl.1	+	2	78	c.46T>C	c.(46-48)TAT>CAT	p.Y16H	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Intron					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						GAAATCTGGCTATGGAAAATA	0.348			NA											3	73					0	0	0.00308	0	0
DEFB123	245936	broad.mit.edu	37	20	30037860	30037860	+	Silent	SNP	T	T	C			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr20:30037860T>C	uc002wvy.2	+	2	178	c.87T>C	c.(85-87)TAT>TAC	p.Y29Y		NM_153324	NP_697019	Q8N688	DB123_HUMAN	defensin, beta 123 precursor	29					defense response to bacterium	extracellular region					0	Lung NSC(7;0.000139)|all_lung(7;0.000197)|all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			GGAATCTTTATGGCAAATGCC	0.428			NA											14	92					0	0	0.004007	0	0
TOP1	7150	broad.mit.edu	37	20	39741460	39741460	+	Silent	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr20:39741460G>A	uc002xjl.2	+	14	1593	c.1347G>A	c.(1345-1347)CGG>CGA	p.R449R	uc002xjn.1_Intron	NM_003286	NP_003277	P11387	TOP1_HUMAN	DNA topoisomerase I	449					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding	p.R449W(1)		breast(3)|ovary(2)|central_nervous_system(1)|kidney(1)	7		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	CTGCTCGGCGGCTGAAAAAAT	0.473			NA	T	NUP98	AML*								3	16					0	0	0.004672	0	0
SULF2	55959	broad.mit.edu	37	20	46307439	46307439	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr20:46307439T>G	uc002xto.2	-	8	1504	c.1174A>C	c.(1174-1176)ACG>CCG	p.T392P	SULF2_uc002xtr.2_Missense_Mutation_p.T392P|SULF2_uc002xtq.2_Missense_Mutation_p.T392P	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	392					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						GGCCGCTCCGTGTCCAGCAGC	0.602			NA											24	126					0	0	0.005443	0	0
ZNF831	128611	broad.mit.edu	37	20	57771017	57771017	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr20:57771017C>T	uc002yan.2	+	2	3832	c.3832C>T	c.(3832-3834)CGT>TGT	p.R1278C		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1278						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					AAAGATGTCTCGTGGGAACAG	0.498			NA											14	104					0	0	0.00245	0	0
PRPF6	24148	broad.mit.edu	37	20	62664298	62664298	+	Silent	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr20:62664298C>T	uc002yho.2	+	21	2946	c.2778C>T	c.(2776-2778)ATC>ATT	p.I926I	PRPF6_uc002yhp.2_Silent_p.I886I|NCRNA00176_uc002yhq.2_5'Flank|NCRNA00176_uc011abq.1_5'Flank	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	926					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					AGAAGAAGATCGGGGACATCC	0.632			NA											4	44					0	0	0.001168	0	0
USP25	29761	broad.mit.edu	37	21	17205774	17205774	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr21:17205774G>C	uc002yjy.1	+	17	2318	c.2101G>C	c.(2101-2103)GAA>CAA	p.E701Q	USP25_uc011aby.1_Missense_Mutation_p.E701Q|USP25_uc002yjz.1_Missense_Mutation_p.E701Q|USP25_uc010gla.1_Intron	NM_013396	NP_037528	Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	701	Potential.				protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		AAAAGAACTAGAAGAATGGGA	0.413			NA											8	43					0	0	0.00308	0	0
CECR2	27443	broad.mit.edu	37	22	18022446	18022446	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr22:18022446G>T	uc010gqw.1	+	15	2674	c.2548G>T	c.(2548-2550)GGG>TGG	p.G850W	CECR2_uc010gqv.1_Missense_Mutation_p.G709W|CECR2_uc002zml.2_Missense_Mutation_p.G709W	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	892					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		GGCTCTTCGGGGGGTGCAGGG	0.632			NA											11	41					4.68919e-08	5.95586e-08	0.008291	1	0
CNTN4	152330	broad.mit.edu	37	3	2908581	2908581	+	Silent	SNP	G	G	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr3:2908581G>T	uc003bpc.2	+	7	821	c.600G>T	c.(598-600)GTG>GTT	p.V200V	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Silent_p.V200V	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	200	Ig-like C2-type 2.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		CCAATACCGTGACAAACCACA	0.388			NA											7	60					0.00198382	0.00214252	0.001984	1	0
RBM5	10181	broad.mit.edu	37	3	50145581	50145581	+	Splice_Site	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr3:50145581G>A	uc003cyg.2	+	13	1267	c.1119_splice	c.e13+1	p.Q373_splice	RBM5_uc011bdj.1_Splice_Site_p.Q317_splice|RBM5_uc011bdk.1_Splice_Site_p.Q201_splice	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5						apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ATATGCTCAGGTAGGTAGATT	0.418			NA											9	54					0	0	0.006214	0	0
RBM5	10181	broad.mit.edu	37	3	50154766	50154766	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr3:50154766G>T	uc003cyg.2	+	24	2424	c.2276G>T	c.(2275-2277)GGC>GTC	p.G759V	RBM5_uc011bdj.1_Missense_Mutation_p.G703V|RBM5_uc011bdk.1_Missense_Mutation_p.G587V|RBM5_uc003cyh.2_Missense_Mutation_p.G216V|uc003cyi.1_RNA	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	759	G-patch.|Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGGCGGGAAGGCTCTGGCTTG	0.547			NA											6	84					8.12818e-05	9.14421e-05	0.001984	1	0
AMBN	258	broad.mit.edu	37	4	71464085	71464085	+	Silent	SNP	T	T	C			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr4:71464085T>C	uc003hfl.2	+	4	223	c.148T>C	c.(148-150)TTG>CTG	p.L50L		NM_016519	NP_057603	Q9NP70	AMBN_HUMAN	ameloblastin precursor	50					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)			AATGAGACAGTTGGGAAGTCT	0.348			NA											5	60					0	0	0.001168	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156631937	156631937	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr4:156631937C>T	uc003iov.2	+	7	1156	c.620C>T	c.(619-621)CCT>CTT	p.P207L	GUCY1A3_uc003iou.2_Missense_Mutation_p.P207L|GUCY1A3_uc010iqc.2_Missense_Mutation_p.P207L|GUCY1A3_uc003iow.2_Missense_Mutation_p.P207L|GUCY1A3_uc010iqd.2_Missense_Mutation_p.P206L|GUCY1A3_uc003iox.2_Missense_Mutation_p.P207L|GUCY1A3_uc003ioz.2_5'UTR|GUCY1A3_uc003ioy.2_Missense_Mutation_p.P207L|GUCY1A3_uc010iqe.2_5'UTR|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Missense_Mutation_p.P207L	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	207					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		TACTTCTTCCCTAAGAGAACC	0.478			NA											5	58					0	0	0.001168	0	0
ADCY2	108	broad.mit.edu	37	5	7520955	7520955	+	Silent	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr5:7520955C>T	uc003jdz.1	+	3	580	c.513C>T	c.(511-513)ATC>ATT	p.I171I		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	171	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CCCACACCATCGTGCTTAGCG	0.572			NA											7	87					0	0	0.001984	0	0
CDH10	1008	broad.mit.edu	37	5	24491685	24491685	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr5:24491685C>A	uc003jgr.1	-	11	2208	c.1876G>T	c.(1876-1878)GTT>TTT	p.V626F	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	626	Helical; (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GGTTTCTTACCCAGTAGAATG	0.483			NA								HNSCC(23;0.051)			17	59					1.99824e-07	2.47488e-07	0.00499	1	0
HCN1	348980	broad.mit.edu	37	5	45396782	45396782	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr5:45396782C>T	uc003jok.2	-	4	1067	c.1042G>A	c.(1042-1044)GCA>ACA	p.A348T		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	348						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TTGAAGAGTGCGTATGAATAC	0.448			NA											11	73					0	0	0.001855	0	0
VCAN	1462	broad.mit.edu	37	5	82835757	82835757	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr5:82835757G>T	uc003kii.3	+	8	7291	c.6935G>T	c.(6934-6936)GGA>GTA	p.G2312V	VCAN_uc003kij.3_Missense_Mutation_p.G1325V|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.G976V	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2312	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AAAGAAGTTGGACCACTCGTA	0.393			NA											11	48					9.70103e-10	1.25927e-09	0.008291	1	0
PGK2	5232	broad.mit.edu	37	6	49754110	49754110	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr6:49754110T>G	uc003ozu.2	-	1	898	c.791A>C	c.(790-792)AAG>ACG	p.K264T		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	264					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					TTTAACGATCTTGGCTCCCTC	0.418			NA											6	110					0	0	0.001168	0	0
COL19A1	1310	broad.mit.edu	37	6	70881870	70881870	+	Silent	SNP	A	A	C			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr6:70881870A>C	uc003pfc.1	+	41	2700	c.2583A>C	c.(2581-2583)GCA>GCC	p.A861A		NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	861	Triple-helical region 5 (COL5).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						AGCCTGGTGCAATGGGGTTGC	0.303			NA											8	28					0	0	0.010729	0	0
SYNE1	23345	broad.mit.edu	37	6	152615182	152615182	+	Silent	SNP	G	G	C			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr6:152615182G>C	uc010kiw.2	-	94	18365	c.17763C>G	c.(17761-17763)TCC>TCG	p.S5921S	SYNE1_uc010kiv.2_Silent_p.S445S|SYNE1_uc003qos.3_Silent_p.S445S|SYNE1_uc003qot.3_Silent_p.S5850S|SYNE1_uc003qou.3_Silent_p.S5921S|SYNE1_uc010kiy.1_Silent_p.S96S	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5921	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGAACTCCTGGGATGCGGATG	0.488			NA								HNSCC(10;0.0054)			14	37					0	0	0.00245	0	0
PKD1L1	168507	broad.mit.edu	37	7	47942012	47942012	+	Silent	SNP	T	T	G			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr7:47942012T>G	uc003tny.1	-	13	2028	c.2028A>C	c.(2026-2028)CCA>CCC	p.P676P		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	676	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						TCACCAGGGGTGGCTGGCAGG	0.552			NA											5	26					0	0	0.000602	0	0
MUC17	140453	broad.mit.edu	37	7	100680433	100680433	+	Silent	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr7:100680433C>T	uc003uxp.1	+	3	5789	c.5736C>T	c.(5734-5736)GAC>GAT	p.D1912D	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1912	Extracellular (Potential).|30.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CAACTGCTGACGGTAGCAGCA	0.507			NA											10	201					0	0	0.013537	0	0
PIK3CG	5294	broad.mit.edu	37	7	106508507	106508507	+	Silent	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr7:106508507C>T	uc003vdv.3	+	2	586	c.501C>T	c.(499-501)AAC>AAT	p.N167N	PIK3CG_uc003vdu.2_Silent_p.N167N|PIK3CG_uc003vdw.2_Silent_p.N167N	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	167					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						ACGTCAGCAACGTGCACGACG	0.667			NA											4	29					0	0	0.000602	0	0
RNF148	378925	broad.mit.edu	37	7	122342159	122342159	+	Nonsense_Mutation	SNP	T	T	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr7:122342159T>A	uc003vkk.1	-	1	863	c.646A>T	c.(646-648)AGA>TGA	p.R216*	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron|RNF133_uc003vkj.1_5'Flank|RNF148_uc010lkr.1_Intron	NM_198085	NP_932351	Q8N7C7	RN148_HUMAN	ring finger protein 148 precursor	216						integral to membrane	zinc ion binding				0						TTGGGCACTCTAGGTGTAAGT	0.448			NA											4	76					0	0	0.000602	0	0
MGAM	8972	broad.mit.edu	37	7	141740570	141740570	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr7:141740570G>A	uc003vwy.2	+	21	2476	c.2422G>A	c.(2422-2424)GGA>AGA	p.G808R		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	808	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GGAACTTCCTGGAGACAAAAT	0.488			NA											6	30					0	0	0.001168	0	0
OR9A2	135924	broad.mit.edu	37	7	142723355	142723355	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr7:142723355G>A	uc003wcc.1	-	1	865	c.865C>T	c.(865-867)CGG>TGG	p.R289W		NM_001001658	NP_001001658	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A,	289	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.059)					TTGTCATTCCGAAGAGTAAAG	0.448			NA											10	40					0	0	0.006214	0	0
EXTL3	2137	broad.mit.edu	37	8	28574075	28574075	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr8:28574075G>A	uc003xgz.1	+	3	1092	c.499G>A	c.(499-501)GGC>AGC	p.G167S		NM_001440	NP_001431	O43909	EXTL3_HUMAN	exostoses-like 3	167	Lumenal (Potential).					integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			skin(2)	2		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		GGACGATGCCGGCCTCCCTCC	0.602			NA											13	47					0	0	0.013537	0	0
CSMD3	114788	broad.mit.edu	37	8	114326834	114326834	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr8:114326834C>T	uc003ynu.2	-	2	526	c.367G>A	c.(367-369)GAT>AAT	p.D123N	CSMD3_uc003ynt.2_Missense_Mutation_p.D83N|CSMD3_uc011lhx.1_Missense_Mutation_p.D123N|CSMD3_uc010mcx.1_Missense_Mutation_p.D123N|CSMD3_uc003ynx.3_Missense_Mutation_p.D123N	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	123	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGATGTCCATCATATAATGAT	0.328			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	54					0	0	0.010729	0	0
CSMD3	114788	broad.mit.edu	37	8	114326898	114326898	+	Silent	SNP	A	A	G			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr8:114326898A>G	uc003ynu.2	-	2	462	c.303T>C	c.(301-303)AAT>AAC	p.N101N	CSMD3_uc003ynt.2_Silent_p.N61N|CSMD3_uc011lhx.1_Silent_p.N101N|CSMD3_uc010mcx.1_Silent_p.N101N|CSMD3_uc003ynx.3_Silent_p.N101N	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	101	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTTGTATTCTATTTCGTTCTT	0.353			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			16	104					0	0	0.004007	0	0
FER1L6	654463	broad.mit.edu	37	8	124998366	124998366	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr8:124998366T>C	uc003yqw.2	+	12	1675	c.1469T>C	c.(1468-1470)ATG>ACG	p.M490T	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	490	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GAAGCTACCATGATTGACCGG	0.274			NA											12	65					0	0	0.001855	0	0
TLR4	7099	broad.mit.edu	37	9	120476501	120476501	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr9:120476501G>C	uc004bjz.2	+	3	2386	c.2095G>C	c.(2095-2097)GGG>CGG	p.G699R	TLR4_uc004bka.2_Missense_Mutation_p.G659R|TLR4_uc004bkb.2_Missense_Mutation_p.G499R	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	699	Cytoplasmic (Potential).|TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TTTAGAAGAAGGGGTGCCTCC	0.438			NA											9	44					0	0	0.006214	0	0
OR1L8	138881	broad.mit.edu	37	9	125330105	125330105	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr9:125330105A>G	uc004bmp.1	-	1	652	c.652T>C	c.(652-654)TCT>CCT	p.S218P		NM_001004454	NP_001004454	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L,	218	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3						CGTATATAAGAGAAAGCAATG	0.433			NA											5	14					0	0	0.000602	0	0
FRMPD4	9758	broad.mit.edu	37	X	12736241	12736241	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chrX:12736241G>T	uc004cuz.1	+	16	3802	c.3296G>T	c.(3295-3297)GGT>GTT	p.G1099V	FRMPD4_uc011mij.1_Missense_Mutation_p.G1091V	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1099					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						GCCACTGAAGGTGGGATGGCT	0.498			NA											18	84					2.35188e-11	3.1436e-11	0.006122	1	0
ABCB7	22	broad.mit.edu	37	X	74288884	74288884	+	Silent	SNP	C	C	A			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chrX:74288884C>A	uc004eca.2	-	12	1642	c.1617G>T	c.(1615-1617)GTG>GTT	p.V539V	ABCB7_uc004ebz.2_Silent_p.V540V|ABCB7_uc011mqn.1_Silent_p.V513V|ABCB7_uc010nls.2_Silent_p.V500V|ABCB7_uc010nlt.2_Silent_p.V499V	NM_004299	NP_004290	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B, member 7	539	ABC transporter.				cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			ovary(1)	1						TTTCCAGGCTCACATCTTGTA	0.398			NA											26	111					3.65163e-15	5.0303e-15	0.00632	1	0
TIMM8A	1678	broad.mit.edu	37	X	100601582	100601582	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chrX:100601582C>T	uc004ehd.2	-	2	504	c.199G>A	c.(199-201)GTT>ATT	p.V67I		NM_004085	NP_004076	O60220	TIM8A_HUMAN	translocase of inner mitochondrial membrane 8	67					nervous system development|protein import into mitochondrial inner membrane|transmembrane transport	mitochondrial inner membrane|mitochondrial intermembrane space protein transporter complex	protein binding				0						AAGCGCTCAACGCAGTTCACA	0.483			NA											31	123					0	0	0.013726	0	0
USP26	83844	broad.mit.edu	37	X	132161641	132161641	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chrX:132161641T>C	uc010nrm.1	-	6	1078	c.608A>G	c.(607-609)TAC>TGC	p.Y203C	USP26_uc011mvf.1_Missense_Mutation_p.Y203C	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	203					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					GGATTTCTTGTATTCTACAGA	0.343	NSCLC(104;342 1621 36940 47097 52632)		NA											17	55					0	0	0.00499	0	0
NELL2	4753	broad.mit.edu	37	12	44917237	44917242	+	In_Frame_Del	DEL	CTGTGC	CTGTGC	-			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	CTGTGC	CTGTGC	-	-	CTGTGC	CTGTGC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr12:44917237_44917242delCTGTGC	uc001rog.2	-	17	2425_2430	c.1830_1835delGCACAG	c.(1828-1836)AGGCACAGC>AGC	p.RH610del	NELL2_uc001rof.3_In_Frame_Del_p.RH609del|NELL2_uc001roh.2_In_Frame_Del_p.RH610del|NELL2_uc009zkd.2_In_Frame_Del_p.RH562del|NELL2_uc010skz.1_In_Frame_Del_p.RH660del|NELL2_uc010sla.1_In_Frame_Del_p.RH633del|NELL2_uc001roi.1_In_Frame_Del_p.RH610del	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	610_611	EGF-like 6; calcium-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		ATTGGCACAGCTGTGCCTCCCGGTCC	0.442			NA											13	72	---	---	---	---	NA	NA	NA	NA	NA
PIGB	9488	broad.mit.edu	37	15	55631502	55631503	+	Frame_Shift_Ins	INS	-	-	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr15:55631502_55631503insT	uc002act.2	+	7	1148_1149	c.832_833insT	c.(832-834)ATTfs	p.I278fs	PIGB_uc010ugg.1_Frame_Shift_Ins_p.I83fs	NM_004855	NP_004846	Q92521	PIGB_HUMAN	phosphatidylinositol glycan, class B	278					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity				0				all cancers(107;0.0255)		GATTGATCGTATTTTTTTTGGC	0.282			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
NF1	4763	broad.mit.edu	37	17	29661894	29661894	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr17:29661894delC	uc002hgg.2	+	40	6184	c.5851delC	c.(5851-5853)CCAfs	p.P1951fs	NF1_uc002hgh.2_Frame_Shift_Del_p.P1930fs|NF1_uc010cso.2_Frame_Shift_Del_p.P139fs|NF1_uc010wbt.1_5'Flank|NF1_uc010wbu.1_5'Flank	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1951			P -> L (in a colorectal cancer sample; somatic mutation).		actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.P1951L(1)|p.P1951fs*6(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ATACATGACTCCATGGCTGTC	0.338			NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			13	56	---	---	---	---	NA	NA	NA	NA	NA
NFKBIB	4793	broad.mit.edu	37	19	39390759	39390759	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr19:39390759delG	uc002ojw.2	+	1	145	c.87delG	c.(85-87)GCGfs	p.A29fs	SIRT2_uc002oju.1_5'Flank|SIRT2_uc010egj.1_5'Flank|SIRT2_uc002ojv.1_5'Flank|SIRT2_uc002ojt.1_5'Flank|NFKBIB_uc010egk.1_Intron|NFKBIB_uc002ojx.2_Frame_Shift_Del_p.R16fs|NFKBIB_uc002ojy.2_Frame_Shift_Del_p.A29fs	NM_002503	NP_002494	Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene	29					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			lung(1)|kidney(1)	2	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CGGACGCAGCGGCCCCCGGAG	0.706	Pancreas(165;1492 2005 6979 7739 34483)		NA									OREG0032100	type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	2	4	---	---	---	---	NA	NA	NA	NA	NA
TTN	7273	broad.mit.edu	37	2	179614019	179614020	+	Frame_Shift_Ins	INS	-	-	T			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr2:179614019_179614020insT	uc002unb.2	-	46	13331_13332	c.13107_13108insA	c.(13105-13110)AAATCAfs	p.K4369fs	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCAGCTTTGATTTTTCACTTA	0.376			NA											34	97	---	---	---	---	NA	NA	NA	NA	NA
CD93	22918	broad.mit.edu	37	20	23064979	23064981	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	CTT	CTT	-	-	CTT	CTT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chr20:23064979_23064981delCTT	uc002wsv.2	-	1	1997_1999	c.1849_1851delAAG	c.(1849-1851)AAGdel	p.K617del		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	617	Cytoplasmic (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GCTTCTTCTCCTTCTTCTCCTCC	0.591			NA											30	166	---	---	---	---	NA	NA	NA	NA	NA
FAM47C	442444	broad.mit.edu	37	X	37028222	37028222	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5068-01A-01D-1625-08	TCGA-50-5068-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c1efdc48-6ea5-45f0-9fa3-94c42ecf3ab4	c2c22c1c-6411-423f-8e81-819f49e60803	g.chrX:37028222delC	uc004ddl.1	+	1	1753	c.1739delC	c.(1738-1740)TCCfs	p.S580fs		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	580										ovary(3)	3						ACTGGAGTGTCCCATCTCTGC	0.657			NA											12	86	---	---	---	---	NA	NA	NA	NA	NA
