Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TNFRSF4	7293	broad.mit.edu	37	1	1148426	1148426	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:1148426C>G	uc001ade.2	-	3	321	c.316G>C	c.(316-318)GTC>CTC	p.V106L	TNFRSF4_uc001adf.2_Missense_Mutation_p.V110L	NM_003327	NP_003318	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily,	106	TNFR-Cys 2.|Extracellular (Potential).				immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CAGCGGCAGACTGTGTCCTGT	0.701			NA											3	27					0	0	0.004672	0	0
TAS1R1	80835	broad.mit.edu	37	1	6636489	6636489	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:6636489C>A	uc001ant.2	+	4	1275	c.1275C>A	c.(1273-1275)ATC>ATA	p.I425I	TAS1R1_uc001anu.2_Silent_p.I171I|TAS1R1_uc001anv.2_Silent_p.I171I|TAS1R1_uc001anw.2_Intron	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	425	Extracellular (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		TGGAGCAGATCCACAAGGTGC	0.507			NA											20	195					0.00121646	0.00139378	0.008871	1	0
ERRFI1	54206	broad.mit.edu	37	1	8074129	8074129	+	Nonsense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:8074129G>C	uc001aoz.2	-	4	779	c.530C>G	c.(529-531)TCA>TGA	p.S177*	ERRFI1_uc001apa.1_Nonsense_Mutation_p.S102*	NM_018948	NP_061821	Q9UJM3	ERRFI_HUMAN	mitogen-inducible gene 6 protein	177					lung alveolus development|lung epithelium development|lung vasculature development|negative regulation of epidermal growth factor receptor activity|negative regulation of protein autophosphorylation|regulation of keratinocyte differentiation|response to stress|skin morphogenesis	cytoplasm|extrinsic to internal side of plasma membrane|nucleus	protein kinase binding|Rho GTPase activator activity			ovary(1)	1	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.33e-70)|GBM - Glioblastoma multiforme(8;8.05e-37)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;6.9e-06)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		GTCTGTATCTGAGCTAGTTAG	0.473			NA											11	62					0	0	0.000978	0	0
SLC45A1	50651	broad.mit.edu	37	1	8390452	8390452	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:8390452G>T	uc001apb.2	+	4	899	c.899G>T	c.(898-900)CGG>CTG	p.R300L	SLC45A1_uc001apc.2_5'UTR	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	300					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		AGTGAGAAGCGGGCAGCCATG	0.687			NA											3	16					0.004672	0.00512029	0.004672	1	0
RERE	473	broad.mit.edu	37	1	8684419	8684419	+	Missense_Mutation	SNP	G	G	A	rs142952294	by1000genomes	TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:8684419G>A	uc001ape.2	-	4	1156	c.346C>T	c.(346-348)CGG>TGG	p.R116W	RERE_uc001apf.2_Missense_Mutation_p.R116W|RERE_uc001aph.1_Missense_Mutation_p.R116W	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	116	BAH.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		TTTGGCCTCCGACTCTCGATA	0.378			NA											7	112					0	0	0.00308	0	0
PTCHD2	57540	broad.mit.edu	37	1	11589657	11589657	+	Missense_Mutation	SNP	G	G	A	rs12096312		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:11589657G>A	uc001ash.3	+	14	2981	c.2843G>A	c.(2842-2844)CGC>CAC	p.R948H		NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	948	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TTCCACGGGCGCGTATGCATG	0.627			NA											7	46					0	0	0.001984	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12853572	12853572	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:12853572C>A	uc001auj.1	+	2	299	c.196C>A	c.(196-198)CTG>ATG	p.L66M		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	66											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTGCCTCCCTCTGGGATCACT	0.542			NA											23	91					7.07758e-08	9.98786e-08	0.004656	1	0
TAS1R2	80834	broad.mit.edu	37	1	19167002	19167002	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:19167002G>T	uc001bba.1	-	6	1612	c.1611C>A	c.(1609-1611)GCC>GCA	p.A537A		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	537	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	TATTCGGGCAGGCCTGGCATT	0.592			NA											4	34					0.00024832	0.000299541	0.009096	1	0
UBR4	23352	broad.mit.edu	37	1	19478267	19478267	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:19478267T>C	uc001bbi.2	-	48	7087	c.7083A>G	c.(7081-7083)ATA>ATG	p.I2361M	UBR4_uc001bbk.1_Missense_Mutation_p.I15M|UBR4_uc001bbl.1_Missense_Mutation_p.I298M|UBR4_uc001bbm.1_Missense_Mutation_p.I1573M	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2361					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GGGCCCGTTCTATTGCTTGAG	0.512			NA											12	50					0	0	0.000978	0	0
UBXN10	127733	broad.mit.edu	37	1	20517691	20517691	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:20517691C>A	uc001bdb.2	+	2	721	c.637C>A	c.(637-639)CGC>AGC	p.R213S		NM_152376	NP_689589	Q96LJ8	UBX10_HUMAN	UBX domain protein 10	213	UBX.									ovary(1)	1						AAGGTTTGTACGCCATTTCCG	0.493			NA											7	56					0.00198382	0.00223792	0.001984	1	0
SERINC2	347735	broad.mit.edu	37	1	31898241	31898241	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:31898241G>T	uc010ogh.1	+	4	670	c.469G>T	c.(469-471)GGC>TGC	p.G157C	SERINC2_uc010ogg.1_Missense_Mutation_p.G154C|SERINC2_uc009vtw.1_Intron|SERINC2_uc001bst.2_Missense_Mutation_p.G153C|SERINC2_uc001bsu.2_Missense_Mutation_p.G98C|SERINC2_uc001bsv.2_Missense_Mutation_p.G98C	NM_178865	NP_849196	Q96SA4	SERC2_HUMAN	tumor differentially expressed 2-like	153						integral to membrane					0		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0629)|Breast(348;0.0707)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0541)|READ - Rectum adenocarcinoma(331;0.151)		CATTCCTGACGGCTCCTTCAC	0.592			NA											10	37					2.32078e-09	3.49073e-09	0.003163	1	0
RBBP4	5928	broad.mit.edu	37	1	33133872	33133872	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:33133872C>A	uc001bvr.2	+	4	516	c.357C>A	c.(355-357)ATC>ATA	p.I119I	RBBP4_uc001bvs.2_Silent_p.I118I|RBBP4_uc010ohj.1_Intron|RBBP4_uc010ohk.1_Silent_p.I84I	NM_005610	NP_005601	Q09028	RBBP4_HUMAN	retinoblastoma binding protein 4 isoform a	119					cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				AAATAGAAATCAAGATCAACC	0.378			NA											7	35					0.00198382	0.00223792	0.001984	1	0
CSMD2	114784	broad.mit.edu	37	1	34174722	34174722	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:34174722C>A	uc001bxn.1	-	22	3452	c.3423G>T	c.(3421-3423)AGG>AGT	p.R1141S	CSMD2_uc001bxm.1_Missense_Mutation_p.R1181S|CSMD2_uc001bxo.1_Missense_Mutation_p.R54S	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1141	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTTCGAATGCCCTGGCTTTCA	0.438			NA											12	81					5.50884e-06	7.30846e-06	0.001368	1	0
THRAP3	9967	broad.mit.edu	37	1	36759490	36759490	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:36759490G>A	uc001cae.3	+	8	2293	c.2069G>A	c.(2068-2070)GGT>GAT	p.G690D	THRAP3_uc001caf.3_Missense_Mutation_p.G690D	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	690					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AGAAAACATGGTTTGGCTCAT	0.348	Pancreas(129;785 1795 20938 23278 32581)		NA	T	USP6	aneurysmal bone cysts								5	180					0	0	0.001168	0	0
NT5C1A	84618	broad.mit.edu	37	1	40131791	40131791	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:40131791C>A	uc001cdq.1	-	2	253	c.253G>T	c.(253-255)GAA>TAA	p.E85*		NM_032526	NP_115915	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	85					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TTCTCATGTTCCAGCTGGTAG	0.483			NA											7	43					8.12818e-05	0.000100707	0.001984	1	0
ZCCHC11	23318	broad.mit.edu	37	1	52901131	52901131	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:52901131T>A	uc001ctx.2	-	27	4400	c.4166A>T	c.(4165-4167)CAG>CTG	p.Q1389L	ZCCHC11_uc001cty.2_Missense_Mutation_p.Q1390L|ZCCHC11_uc001ctz.2_Missense_Mutation_p.Q1385L|ZCCHC11_uc001cua.1_Missense_Mutation_p.Q307L	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	1389					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						GCGGACCAGCTGGGCTGCTAA	0.418			NA											9	36					0	0	0.006214	0	0
LEPR	3953	broad.mit.edu	37	1	66075681	66075681	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:66075681G>T	uc001dci.2	+	13	2006	c.1804G>T	c.(1804-1806)GAC>TAC	p.D602Y	LEPR_uc001dcg.2_Missense_Mutation_p.D602Y|LEPR_uc001dch.2_Missense_Mutation_p.D602Y|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Missense_Mutation_p.D602Y|LEPR_uc001dck.2_Missense_Mutation_p.D602Y	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	602	Extracellular (Potential).|Fibronectin type-III 2.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		CCCAGTTCCAGACTTGTGTGC	0.408			NA											53	148					6.3091e-27	1.14725e-26	0.00361	1	0
GNG12	55970	broad.mit.edu	37	1	68173365	68173365	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:68173365G>A	uc001dea.1	-	3	197	c.5C>T	c.(4-6)TCC>TTC	p.S2F		NM_018841	NP_061329	Q9UBI6	GBG12_HUMAN	G-protein gamma-12 subunit precursor	2					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity				0						TGTTTTGCTGGACATCTTCAA	0.348			NA											35	237					0	0	0.003755	0	0
WLS	79971	broad.mit.edu	37	1	68659674	68659674	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:68659674G>T	uc001def.1	-	2	614	c.343C>A	c.(343-345)CAG>AAG	p.Q115K	uc001deb.1_Intron|uc001dec.1_Intron|WLS_uc001dee.2_Missense_Mutation_p.Q113K|WLS_uc001deg.1_Intron|WLS_uc001deh.1_Missense_Mutation_p.Q115K|WLS_uc009wbf.1_Missense_Mutation_p.Q70K	NM_024911	NP_079187	Q5T9L3	WLS_HUMAN	G protein-coupled receptor 177 isoform 1	115	Lumenal (Potential).|Interacts with Wnt proteins (By similarity).				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity				0						ATGTCCAGCTGCAGGATAAAC	0.448			NA											8	68					2.17888e-05	2.81406e-05	0.006214	1	0
PTGER3	5733	broad.mit.edu	37	1	71512593	71512593	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:71512593T>C	uc001dfg.1	-	1	899	c.668A>G	c.(667-669)CAT>CGT	p.H223R	PTGER3_uc001dfh.1_RNA|PTGER3_uc001dfi.1_RNA|PTGER3_uc001dfj.1_RNA|PTGER3_uc001dfk.1_Missense_Mutation_p.H223R|PTGER3_uc001dfl.1_Missense_Mutation_p.H223R|PTGER3_uc009wbm.1_Missense_Mutation_p.H223R|PTGER3_uc001dfm.1_RNA|PTGER3_uc001dfn.2_Missense_Mutation_p.H223R|PTGER3_uc009wbn.1_Missense_Mutation_p.H223R|PTGER3_uc009wbo.2_Missense_Mutation_p.H223R|PTGER3_uc001dfo.2_Missense_Mutation_p.H223R|PTGER3_uc001dfp.1_Missense_Mutation_p.H223R|PTGER3_uc001dfq.2_Missense_Mutation_p.H223R|uc001dfr.2_RNA	NM_198714	NP_942007	P43115	PE2R3_HUMAN	prostaglandin E receptor 3, subtype EP3 isoform	223	Extracellular (Potential).				cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			pancreas(1)|lung(1)|skin(1)	3					Bimatoprost(DB00905)	GCCCCAGTTATGCGAAGAGCT	0.632			NA											8	93					0	0	0.008291	0	0
TNNI3K	51086	broad.mit.edu	37	1	74801830	74801830	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:74801830G>C	uc001dgf.1	+	7	730	c.679G>C	c.(679-681)GAT>CAT	p.D227H	TNNI3K_uc001dgc.1_Missense_Mutation_p.D328H|TNNI3K_uc001dgd.2_Missense_Mutation_p.D328H|TNNI3K_uc001dge.1_Missense_Mutation_p.D328H	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	227	ANK 5.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						CAGCAAAGCAGATGGTAAGAT	0.348			NA											8	35					0	0	0.00308	0	0
C1orf173	127254	broad.mit.edu	37	1	75037607	75037607	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:75037607C>T	uc001dgg.2	-	14	4006	c.3787G>A	c.(3787-3789)GGA>AGA	p.G1263R		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1263	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						ACATCCACTCCTCCTTGCCCT	0.592			NA											13	122					0	0	0.001855	0	0
C1orf173	127254	broad.mit.edu	37	1	75038256	75038256	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:75038256C>G	uc001dgg.2	-	14	3357	c.3138G>C	c.(3136-3138)AGG>AGC	p.R1046S		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1046	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						AAATTTCTTTCCTATCATCTT	0.453			NA											31	165					0	0	0.002096	0	0
C1orf173	127254	broad.mit.edu	37	1	75039035	75039035	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:75039035C>T	uc001dgg.2	-	14	2578	c.2359G>A	c.(2359-2361)GAC>AAC	p.D787N		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	787	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TGTACTATGTCAGCATCTCTG	0.522			NA											17	97					0	0	0.004007	0	0
TYW3	127253	broad.mit.edu	37	1	75204454	75204454	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:75204454G>A	uc001dgn.2	+	3	425	c.336G>A	c.(334-336)TTG>TTA	p.L112L	TYW3_uc010oqw.1_Intron|TYW3_uc010oqx.1_Intron|TYW3_uc010oqy.1_RNA	NM_138467	NP_612476	Q6IPR3	TYW3_HUMAN	tRNA-yW synthesizing protein 3 homolog isoform	112					tRNA processing		methyltransferase activity			ovary(2)	2						GTCGACAATTGCAGGATGCAC	0.328			NA											5	42					0	0	0.000602	0	0
LPHN2	23266	broad.mit.edu	37	1	82456781	82456781	+	Silent	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:82456781A>T	uc001dit.3	+	21	4345	c.4164A>T	c.(4162-4164)CCA>CCT	p.P1388P	LPHN2_uc001dis.2_Silent_p.P368P|LPHN2_uc001diu.2_Silent_p.P1388P|LPHN2_uc001div.2_3'UTR|LPHN2_uc009wcd.2_3'UTR|LPHN2_uc001diw.2_Silent_p.P1015P	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	1444	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		ggtgtattccagAAGGAGATG	0.184			NA											4	38					0	0	0.009096	0	0
PRKACB	5567	broad.mit.edu	37	1	84650823	84650823	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:84650823G>T	uc001djj.2	+	5	641	c.377G>T	c.(376-378)GGG>GTG	p.G126V	PRKACB_uc001djl.2_Missense_Mutation_p.G173V|PRKACB_uc010ort.1_Missense_Mutation_p.G133V|PRKACB_uc001djn.2_Missense_Mutation_p.G130V|PRKACB_uc010oru.1_Missense_Mutation_p.G114V|PRKACB_uc001djp.2_Missense_Mutation_p.G132V|PRKACB_uc001djq.2_Missense_Mutation_p.G96V|PRKACB_uc010orv.1_Missense_Mutation_p.G113V|PRKACB_uc001dji.2_Missense_Mutation_p.G126V|PRKACB_uc001djk.2_Missense_Mutation_p.G173V|PRKACB_uc009wcf.1_Missense_Mutation_p.G132V	NM_002731	NP_002722	P22694	KAPCB_HUMAN	cAMP-dependent protein kinase catalytic subunit	126	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|regulation of insulin secretion|synaptic transmission|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|magnesium ion binding|protein binding			lung(2)|ovary(1)	3				all cancers(265;0.00536)|Epithelial(280;0.0161)|OV - Ovarian serous cystadenocarcinoma(397;0.141)		TATGTCCCTGGGGGTGAAATG	0.284			NA											43	124					3.19069e-20	5.67492e-20	0.00361	1	0
GBP6	163351	broad.mit.edu	37	1	89849285	89849285	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:89849285C>A	uc001dnf.2	+	9	1714	c.1440C>A	c.(1438-1440)GCC>GCA	p.A480A	GBP6_uc010ost.1_Silent_p.A350A	NM_198460	NP_940862	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	480							GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		CAGATAAAGCCCTCACTGATA	0.473			NA											18	50					1.96292e-10	3.05948e-10	0.010504	1	0
DPYD	1806	broad.mit.edu	37	1	97981341	97981341	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:97981341G>A	uc001drv.2	-	13	1818	c.1681C>T	c.(1681-1683)CGA>TGA	p.R561*		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	561					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AAAGCTCTTCGAATCATTGAT	0.388			NA											6	53					0	0	0.001984	0	0
COL11A1	1301	broad.mit.edu	37	1	103428212	103428212	+	Silent	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:103428212T>A	uc001dul.2	-	39	3339	c.3021A>T	c.(3019-3021)GCA>GCT	p.A1007A	COL11A1_uc001duk.2_Silent_p.A203A|COL11A1_uc001dum.2_Silent_p.A1019A|COL11A1_uc001dun.2_Silent_p.A968A|COL11A1_uc009weh.2_Silent_p.A891A	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1007	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GTTGTACCTTTGCACCTTCTT	0.463			NA											23	50					0	0	0.002299	0	0
KIAA1324	57535	broad.mit.edu	37	1	109743374	109743374	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:109743374C>T	uc001dwq.2	+	22	2961	c.2825C>T	c.(2824-2826)TCC>TTC	p.S942F	KIAA1324_uc009wex.1_Missense_Mutation_p.S892F|KIAA1324_uc009wey.2_Missense_Mutation_p.S855F|KIAA1324_uc010ovg.1_Missense_Mutation_p.S840F|KIAA1324_uc001dwr.2_Missense_Mutation_p.S592F	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	942	Cytoplasmic (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		TACAAGTACTCCAAGCTGGTG	0.483			NA									OREG0013630	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	41					0	0	0.004482	0	0
KCNA2	3737	broad.mit.edu	37	1	111146070	111146070	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:111146070C>G	uc001dzu.2	-	2	1831	c.1335G>C	c.(1333-1335)AAG>AAC	p.K445N	KCNA2_uc009wfv.1_Intron|KCNA2_uc009wfw.2_Missense_Mutation_p.K445N	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	445						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		TTCTACTTTTCTTTAGGTCAG	0.438	Pancreas(18;568 735 10587 23710 36357)		NA											20	134					0	0	0.002299	0	0
KCNA2	3737	broad.mit.edu	37	1	111147160	111147160	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:111147160C>A	uc001dzu.2	-	2	741	c.245G>T	c.(244-246)CGC>CTC	p.R82L	KCNA2_uc009wfv.1_Missense_Mutation_p.R82L|KCNA2_uc009wfw.2_Missense_Mutation_p.R82L	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	82						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		AAAGCTAGGGCGGTTCCGATC	0.478	Pancreas(18;568 735 10587 23710 36357)		NA											11	70					6.40141e-05	8.01272e-05	0.000978	1	0
KCND3	3752	broad.mit.edu	37	1	112524479	112524479	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:112524479C>A	uc001ebu.1	-	2	1350	c.870G>T	c.(868-870)CGG>CGT	p.R290R	KCND3_uc001ebv.1_Silent_p.R290R	NM_004980	NP_004971	Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related	290	Helical; Voltage-sensor; Name=Segment S4; (Potential).					sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			ovary(2)|large_intestine(1)	3		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		CGCGGAAGACCCGGAGCGTGA	0.597			NA											5	54					0.000602214	0.000706611	0.000602	1	0
HSD3B2	3284	broad.mit.edu	37	1	119962113	119962113	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:119962113G>T	uc001ehs.2	+	2	988	c.215G>T	c.(214-216)TGC>TTC	p.C72F	HSD3B2_uc001eht.2_Missense_Mutation_p.C72F|HSD3B2_uc001ehu.2_Missense_Mutation_p.C72F	NM_000198	NP_000189	P26439	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase 2	72					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	AAAAGAGCCTGCCAGGACGTC	0.488			NA											15	43					2.61681e-11	4.18576e-11	0.00245	1	0
FLG	2312	broad.mit.edu	37	1	152285620	152285620	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:152285620G>T	uc001ezu.1	-	3	1778	c.1742C>A	c.(1741-1743)ACC>AAC	p.T581N	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	581	Filaggrin 3.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAGTGCCTGGTGCCGTCTCC	0.562			NA							Ichthyosis				83	328					1.72036e-36	3.16772e-36	0.00361	1	0
FLG	2312	broad.mit.edu	37	1	152285768	152285768	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:152285768G>T	uc001ezu.1	-	3	1630	c.1594C>A	c.(1594-1596)CAC>AAC	p.H532N	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	532	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATTGCTCGTGGTGGGATCCC	0.597			NA							Ichthyosis				56	513					1.93748e-29	3.54962e-29	0.00361	1	0
FLG2	388698	broad.mit.edu	37	1	152329306	152329306	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:152329306G>T	uc001ezw.3	-	3	1029	c.956C>A	c.(955-957)TCA>TAA	p.S319*	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	319	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTAATTCCTGACTGACAGCC	0.483			NA											32	252					2.81731e-10	4.38182e-10	0.002096	1	0
KPRP	448834	broad.mit.edu	37	1	152733428	152733428	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:152733428G>A	uc001fal.1	+	2	1422	c.1364G>A	c.(1363-1365)TGT>TAT	p.C455Y		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	455	Pro-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAGGGCAGTGTGAGATTCCA	0.612			NA											31	96					0	0	0.002096	0	0
SPRR2B	6701	broad.mit.edu	37	1	153043164	153043164	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:153043164T>A	uc001fbg.2	-	2	215	c.152A>T	c.(151-153)CAG>CTG	p.Q51L	SPRR2D_uc009wnz.2_Intron|SPRR2A_uc001fbf.2_Intron|SPRR2A_uc009woa.2_Intron	NM_001017418	NP_001017418	P35325	SPR2B_HUMAN	small proline-rich protein 2B	51					keratinization	cornified envelope|cytoplasm					0	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ATATTTCTGCTGGCACTGCTG	0.587			NA											40	116					0	0	0.00361	0	0
SLC27A3	11000	broad.mit.edu	37	1	153747848	153747848	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:153747848C>A	uc001fcz.2	+	1	81	c.16C>A	c.(16-18)CGC>AGC	p.R6S	SLC27A3_uc009won.2_RNA	NM_024330	NP_077306	Q5K4L6	S27A3_HUMAN	solute carrier family 27 member 3	6					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			ovary(1)	1	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CGTGTGCCAGCGCACGCGCGC	0.672			NA											6	58					0.00116845	0.00134087	0.001168	1	0
TTC24	164118	broad.mit.edu	37	1	156554984	156554984	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:156554984G>C	uc009wsc.1	+	6	717	c.577G>C	c.(577-579)GCA>CCA	p.A193P		NM_001105669	NP_001099139	A2A3L6	TTC24_HUMAN	tetratricopeptide repeat domain 24	473							binding			pancreas(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGAGAGGTCGGCAAACGTTCC	0.562			NA											3	43					0	0	0.009096	0	0
NES	10763	broad.mit.edu	37	1	156642540	156642540	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:156642540C>T	uc001fpq.2	-	4	1573	c.1440G>A	c.(1438-1440)AAG>AAA	p.K480K		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	480	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ATTCTCCATCCTTAGCCTCTA	0.587			NA											28	175					0	0	0.009535	0	0
CD5L	922	broad.mit.edu	37	1	157803102	157803102	+	Missense_Mutation	SNP	G	G	T	rs74121552	byFrequency	TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:157803102G>T	uc001frk.3	-	5	1062	c.919C>A	c.(919-921)CGC>AGC	p.R307S		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	307	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			AGCCAGATGCGGCCAACCCCA	0.582			NA											47	47					2.54085e-39	4.70218e-39	0.00361	1	0
KIRREL	55243	broad.mit.edu	37	1	158064446	158064446	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:158064446G>T	uc001frn.3	+	15	2214	c.1810G>T	c.(1810-1812)GGC>TGC	p.G604C	KIRREL_uc010pib.1_Missense_Mutation_p.G504C|KIRREL_uc009wsq.2_Missense_Mutation_p.G440C|KIRREL_uc001fro.3_Missense_Mutation_p.G418C|uc001frp.2_5'Flank	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	604	Cytoplasmic (Potential).			DTREEYEMKDPTNGY -> ERPRIRGRLNTSYSD (in Ref. 1).		integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					CCCCACCAATGGCTACTACAA	0.627			NA											4	52					0.00024832	0.000299541	0.009096	1	0
CD1E	913	broad.mit.edu	37	1	158325207	158325207	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:158325207C>A	uc001fse.2	+	3	712	c.473C>A	c.(472-474)TCT>TAT	p.S158Y	CD1E_uc010pid.1_Missense_Mutation_p.S156Y|CD1E_uc010pie.1_Missense_Mutation_p.S59Y|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Missense_Mutation_p.S158Y|CD1E_uc001fsk.2_Intron|CD1E_uc001fsj.2_Intron|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.S158Y|CD1E_uc001fry.2_Missense_Mutation_p.S158Y|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Missense_Mutation_p.S158Y|CD1E_uc009wsv.2_Missense_Mutation_p.S59Y|CD1E_uc001frz.2_Intron|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	158					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					TGGGAGCCATCTCCAGGAGCA	0.458			NA											37	120					1.66425e-11	2.69152e-11	0.004878	1	0
SPTA1	6708	broad.mit.edu	37	1	158592861	158592861	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:158592861G>A	uc001fst.1	-	43	6231	c.6032C>T	c.(6031-6033)GCC>GTC	p.A2011V		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2011	Spectrin 19.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CAGCAGAGCGGCATAACGCTC	0.483			NA											6	468					0	0	0.001168	0	0
OR6N1	128372	broad.mit.edu	37	1	158736362	158736362	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:158736362C>A	uc010piq.1	-	1	111	c.111G>T	c.(109-111)ATG>ATT	p.M37I		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	37	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					CCAACACAGTCATGAGGTAAA	0.507			NA											5	42					3.59834e-05	4.59055e-05	0.001168	1	0
CD48	962	broad.mit.edu	37	1	160654959	160654959	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:160654959C>T	uc001fwn.2	-	2	135	c.103G>A	c.(103-105)GTG>ATG	p.V35M	CD48_uc001fwo.1_Missense_Mutation_p.V35M|CD48_uc001fwp.2_Missense_Mutation_p.V35M	NM_001778	NP_001769	P09326	CD48_HUMAN	CD48 molecule precursor	35	Ig-like C2-type 1.				blood coagulation|defense response|leukocyte migration	integral to plasma membrane|membrane raft	protein binding				0	all_cancers(52;2.18e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CCGGAGACCACGGTCATATGT	0.512			NA											6	42					0	0	0.00308	0	0
HSPA7	3311	broad.mit.edu	37	1	161576686	161576686	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:161576686G>T	uc010pkp.1	+	1	838	c.606G>T	c.(604-606)CTG>CTT	p.L202L		NR_024151				RecName: Full=Putative heat shock 70 kDa protein 7; AltName: Full=Heat shock 70 kDa protein B;												0						TTTTTGACCTGGGTGGGGGCA	0.607			NA											11	72					1.49906e-05	1.95681e-05	0.00245	1	0
FCRLA	84824	broad.mit.edu	37	1	161681852	161681852	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:161681852T>A	uc001gbe.2	+	5	939	c.697T>A	c.(697-699)TAC>AAC	p.Y233N	FCRLA_uc001gbd.2_Missense_Mutation_p.Y227N|FCRLA_uc001gbf.2_Missense_Mutation_p.Y138N|FCRLA_uc001gbg.2_Missense_Mutation_p.Y87N|FCRLA_uc009wuo.2_Missense_Mutation_p.Y93N|FCRLA_uc009wup.2_Intron|FCRLA_uc009wuq.2_Intron	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	210	Ig-like C2-type 2.				cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			CTTCTCCTTCTACAAGGATGG	0.562			NA											16	112					0	0	0.006122	0	0
DDR2	4921	broad.mit.edu	37	1	162724645	162724645	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:162724645G>T	uc001gcf.2	+	6	882	c.417G>T	c.(415-417)CAG>CAT	p.Q139H	DDR2_uc001gcg.2_Missense_Mutation_p.Q139H	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	139	Extracellular (Potential).|F5/8 type C.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			ATGGGAAACAGGTAGGAAGAA	0.493	NSCLC(161;314 2006 8283 19651 23192)		NA											10	35					4.68919e-08	6.66887e-08	0.008291	1	0
DDR2	4921	broad.mit.edu	37	1	162724952	162724952	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:162724952G>A	uc001gcf.2	+	7	889	c.424G>A	c.(424-426)GAT>AAT	p.D142N	DDR2_uc001gcg.2_Missense_Mutation_p.D142N	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	142	Extracellular (Potential).|F5/8 type C.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			TCAGGTGCTGGATGGAAATAG	0.458	NSCLC(161;314 2006 8283 19651 23192)		NA											13	121					0	0	0.00245	0	0
LMX1A	4009	broad.mit.edu	37	1	165182967	165182967	+	Missense_Mutation	SNP	G	G	T	rs149908681		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:165182967G>T	uc001gcy.1	-	4	801	c.580C>A	c.(580-582)CGC>AGC	p.R194S	LMX1A_uc001gcz.1_Missense_Mutation_p.R194S|LMX1A_uc001gcw.1_5'Flank|LMX1A_uc001gcx.1_5'Flank	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	194						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					CGTTTGGGGCGCTTATGGTCC	0.502			NA											28	262					1.08312e-15	1.86736e-15	0.009535	1	0
ALDH9A1	223	broad.mit.edu	37	1	165638193	165638193	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:165638193C>T	uc001gdh.1	-	8	1282	c.1177G>A	c.(1177-1179)GAT>AAT	p.D393N	ALDH9A1_uc010pky.1_Missense_Mutation_p.D299N|ALDH9A1_uc010pkz.1_Missense_Mutation_p.D383N|ALDH9A1_uc010pla.1_Missense_Mutation_p.D299N	NM_000696	NP_000687	P49189	AL9A1_HUMAN	aldehyde dehydrogenase 9A1	369					carnitine biosynthetic process|cellular aldehyde metabolic process|hormone metabolic process|neurotransmitter biosynthetic process	cytosol|plasma membrane	3-chloroallyl aldehyde dehydrogenase activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aminobutyraldehyde dehydrogenase activity				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				NADH(DB00157)	TAATATCCATCCTTTAATTTG	0.279	Ovarian(179;1583 2014 18106 33801 42447)		NA											9	88					0	0	0.008291	0	0
GPR161	23432	broad.mit.edu	37	1	168065747	168065747	+	Silent	SNP	T	T	A	rs28679686		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:168065747T>A	uc001gfc.2	-	5	1412	c.1098A>T	c.(1096-1098)ACA>ACT	p.T366T	GPR161_uc001gfb.2_Silent_p.T234T|GPR161_uc010pll.1_Silent_p.T276T|GPR161_uc010plm.1_Silent_p.T252T|GPR161_uc009wvo.2_Silent_p.T383T|GPR161_uc001gfd.2_Silent_p.T366T|GPR161_uc010pln.1_Silent_p.T386T|GPR161_uc001gfe.1_Silent_p.T366T	NM_153832	NP_722561	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161 isoform 2	366	Cytoplasmic (Potential).				multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_hematologic(923;0.215)					CCAAGTTACCTGTGATCCTGT	0.517			NA											5	52					0	0	0.001168	0	0
PAPPA2	60676	broad.mit.edu	37	1	176668531	176668531	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:176668531T>G	uc001gkz.2	+	8	4206	c.3042T>G	c.(3040-3042)GAT>GAG	p.D1014E	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1014					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TGCACGTGGATGGGAAGGTGT	0.517			NA											27	152					0	0	0.004656	0	0
RGS8	85397	broad.mit.edu	37	1	182635138	182635138	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:182635138C>A	uc010pnw.1	-	5	417	c.159G>T	c.(157-159)TGG>TGT	p.W53C	RGS8_uc001gpn.1_Missense_Mutation_p.W53C|RGS8_uc001gpm.1_Missense_Mutation_p.W71C	NM_001102450	NP_001095920	P57771	RGS8_HUMAN	regulator of G-protein signalling 8 isoform 2	53					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)	1						AGGAATCTGCCCACCTCGTAG	0.398	Ovarian(189;1262 3804 41973)		NA											36	101					5.8336e-16	1.01051e-15	0.003271	1	0
HMCN1	83872	broad.mit.edu	37	1	186077635	186077635	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:186077635C>T	uc001grq.1	+	71	11124	c.10895C>T	c.(10894-10896)ACT>ATT	p.T3632I		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3632	Ig-like C2-type 35.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CGGGATATCACTGTGTTACGG	0.423			NA											32	79					0	0	0.002836	0	0
TPR	7175	broad.mit.edu	37	1	186322924	186322925	+	Missense_Mutation	DNP	CA	CA	TT			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:186322924_186322925CA>TT	uc001grv.2	-	18	2526_2527	c.2229_2230TG>AA	c.(2227-2232)CATGAG>CAAAAG	p.743_744HE>QK		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	743_744	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TGATTTCTCTCATGAAGTGATG	0.361			NA	T	NTRK1	papillary thyroid								4	121					0	0	0.004672	0	0
CHIT1	1118	broad.mit.edu	37	1	203186156	203186156	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:203186156T>A	uc001gzn.2	-	11	1358	c.1262A>T	c.(1261-1263)CAG>CTG	p.Q421L	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_Intron|CHIT1_uc009xal.1_Missense_Mutation_p.Q183L|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Missense_Mutation_p.Q412L	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	421	Chitin-binding type-2.				chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						AGCTTTGCCCTGGCAGAACGT	0.602			NA									OREG0014113	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	81					0	0	0.006122	0	0
NEK2	4751	broad.mit.edu	37	1	211848791	211848791	+	Silent	SNP	A	A	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:211848791A>G	uc001hir.1	-	1	177	c.31T>C	c.(31-33)TTG>CTG	p.L11L	NEK2_uc001hiq.1_Silent_p.L11L|NEK2_uc001his.3_Silent_p.L11L|NEK2_uc001hit.1_RNA	NM_002497	NP_002488	P51955	NEK2_HUMAN	NIMA-related kinase 2	11	Protein kinase.				cell division|centrosome separation|G2/M transition of mitotic cell cycle|meiosis|protein autophosphorylation|regulation of mitosis	centrosome|condensed chromosome kinetochore|cytosol|nucleolus	ATP binding|metal ion binding|protein binding|protein phosphatase binding|protein serine/threonine kinase activity			breast(2)|stomach(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.00203)|all cancers(67;0.0339)|Epithelial(68;0.0546)		ATGGTGTACAACACTTCATAG	0.652			NA											21	72					0	0	0.001882	0	0
USH2A	7399	broad.mit.edu	37	1	215802171	215802171	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:215802171G>T	uc001hku.1	-	71	15891	c.15504C>A	c.(15502-15504)GGC>GGA	p.G5168G		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	5168	Cytoplasmic (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CACTGTTGTGGCCCATGATGG	0.493			NA								HNSCC(13;0.011)			36	71					6.70999e-13	1.10722e-12	0.004289	1	0
USH2A	7399	broad.mit.edu	37	1	216173810	216173810	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:216173810C>A	uc001hku.1	-	33	6807	c.6420G>T	c.(6418-6420)CAG>CAT	p.Q2140H		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2140	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTGGTGGCAGCTGTGCTGTGT	0.463			NA								HNSCC(13;0.011)			11	59					0.000673444	0.000783897	0.008291	1	0
USH2A	7399	broad.mit.edu	37	1	216405371	216405371	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:216405371G>C	uc001hku.1	-	14	3304	c.2917C>G	c.(2917-2919)CAA>GAA	p.Q973E	USH2A_uc001hkv.2_Missense_Mutation_p.Q973E	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	973	Extracellular (Potential).|Laminin EGF-like 9.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GAAGCATCTTGGCAAACACAC	0.443			NA								HNSCC(13;0.011)			12	122					0	0	0.001855	0	0
USH2A	7399	broad.mit.edu	37	1	216420237	216420237	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:216420237G>T	uc001hku.1	-	13	2886	c.2499C>A	c.(2497-2499)AAC>AAA	p.N833K	USH2A_uc001hkv.2_Missense_Mutation_p.N833K	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	833	Extracellular (Potential).|Laminin EGF-like 6.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTAGGTAGAAGTTTCCCTCCA	0.463			NA								HNSCC(13;0.011)			16	116					4.7546e-09	7.04993e-09	0.004007	1	0
EXOC8	149371	broad.mit.edu	37	1	231472329	231472329	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:231472329C>T	uc001huq.2	-	1	1250	c.1163G>A	c.(1162-1164)CGA>CAA	p.R388Q		NM_175876	NP_787072	Q8IYI6	EXOC8_HUMAN	exocyst complex 84-kDa subunit	388					exocytosis|protein transport	growth cone|nucleus	protein binding			skin(1)	1	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				AGTGAGCTGTCGAACTCGCTC	0.532			NA											6	54					0	0	0.001168	0	0
ACTN2	88	broad.mit.edu	37	1	236881160	236881160	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:236881160C>A	uc001hyf.2	+	2	333	c.129C>A	c.(127-129)ACC>ACA	p.T43T	ACTN2_uc001hyg.2_5'UTR|ACTN2_uc009xgi.1_Silent_p.T43T	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	43	CH 1.|Actin-binding.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CTTTGCAGACCTTCACTGCCT	0.493			NA											6	16					0.00198382	0.00223792	0.001984	1	0
RYR2	6262	broad.mit.edu	37	1	237620007	237620007	+	Silent	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:237620007C>G	uc001hyl.1	+	16	1704	c.1584C>G	c.(1582-1584)TCC>TCG	p.S528S		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	528	Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTTGGAAATCCATTCTGAATT	0.413			NA											15	87					0	0	0.00245	0	0
RYR2	6262	broad.mit.edu	37	1	237664013	237664013	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:237664013T>A	uc001hyl.1	+	21	2326	c.2206T>A	c.(2206-2208)TGT>AGT	p.C736S		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	736	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CCCAATAGGTTGTATTGCTCG	0.398			NA											69	274					0	0	0.00361	0	0
RYR2	6262	broad.mit.edu	37	1	237806676	237806676	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:237806676G>C	uc001hyl.1	+	48	7391	c.7271G>C	c.(7270-7272)AGA>ACA	p.R2424T		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2424	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCCATTTTGAGATCCCTCATT	0.423			NA											18	141					0	0	0.001882	0	0
RYR2	6262	broad.mit.edu	37	1	237817625	237817625	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:237817625G>T	uc001hyl.1	+	52	7996	c.7876G>T	c.(7876-7878)GGG>TGG	p.G2626W		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2626	Modulator (Potential).|Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CCTGCCTGGAGGGTGGGGAAA	0.383			NA											12	66					4.36969e-10	6.7106e-10	0.001855	1	0
CHRM3	1131	broad.mit.edu	37	1	240072465	240072465	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:240072465C>A	uc001hyp.2	+	5	2493	c.1714C>A	c.(1714-1716)CAG>AAG	p.Q572K		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	572	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GCGCAAGCAGCAGTACCAGCA	0.493			NA											8	50					2.17888e-05	2.81406e-05	0.006214	1	0
AKT3	10000	broad.mit.edu	37	1	243736348	243736348	+	Silent	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:243736348C>G	uc001iab.1	-	8	780	c.699G>C	c.(697-699)CTG>CTC	p.L233L	AKT3_uc001hzz.1_Silent_p.L233L	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	233	Protein kinase.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			AATGGAAAAACAGCTGCAGGG	0.433			NA											3	51					0	0	0.004672	0	0
OR2L2	26246	broad.mit.edu	37	1	248202135	248202135	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:248202135C>A	uc001idw.2	+	1	662	c.566C>A	c.(565-567)ACA>AAA	p.T189K	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CTAGCCTGCACAGACACTTGG	0.458			NA											34	216					3.62531e-18	6.37043e-18	0.004289	1	0
OR2L13	284521	broad.mit.edu	37	1	248263100	248263100	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:248263100G>T	uc001ids.2	+	3	760	c.423G>T	c.(421-423)GTG>GTT	p.V141V		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	141	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TGATGTGTGTGAAGATGATTG	0.493			NA											45	185					7.88023e-25	1.42585e-24	0.00361	1	0
OR2M1P	388762	broad.mit.edu	37	1	248285550	248285550	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:248285550C>T	uc001idy.1	+	1	113	c.113C>T	c.(112-114)TCA>TTA	p.S38L		NR_002141				RecName: Full=Olfactory receptor 2M5;												0						TTCTGTGTATCACTGCTTGGC	0.463			NA											23	216					0	0	0.00333	0	0
OR2M3	127062	broad.mit.edu	37	1	248367167	248367167	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:248367167C>A	uc010pzg.1	+	1	798	c.798C>A	c.(796-798)CGC>CGA	p.R266R		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CATCTGATCGCTCCCCAACAC	0.502			NA											17	154					5.35267e-07	7.3966e-07	0.007413	1	0
DIP2C	22982	broad.mit.edu	37	10	465069	465069	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:465069C>G	uc001ifp.2	-	6	765	c.675G>C	c.(673-675)CAG>CAC	p.Q225H		NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	225						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		CCGTGGAACCCTGCGGTCTCT	0.532			NA											10	77					0	0	0.001368	0	0
CAMK1D	57118	broad.mit.edu	37	10	12870807	12870807	+	Missense_Mutation	SNP	C	C	T	rs148446769		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:12870807C>T	uc001ilo.2	+	11	1314	c.1079C>T	c.(1078-1080)TCG>TTG	p.S360L		NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	360	Ser-rich.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		ATTTCTTCTTCGTCGGGGGTC	0.592			NA											6	53					0	0	0.004482	0	0
ARMC4	55130	broad.mit.edu	37	10	28228927	28228927	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:28228927G>A	uc009xky.2	-	14	2094	c.1996C>T	c.(1996-1998)CGG>TGG	p.R666W	ARMC4_uc010qds.1_Missense_Mutation_p.R191W|ARMC4_uc010qdt.1_Missense_Mutation_p.R358W|ARMC4_uc001itz.2_Missense_Mutation_p.R666W	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	666	ARM 4.						binding			ovary(4)|skin(2)	6						ATTGCAGCCCGGTAGTTTTCC	0.373			NA											5	38					0	0	0.000602	0	0
BAMBI	25805	broad.mit.edu	37	10	28970327	28970327	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:28970327C>T	uc001iuj.1	+	2	620	c.217C>T	c.(217-219)CTT>TTT	p.L73F	BAMBI_uc001iui.2_Missense_Mutation_p.L73F	NM_012342	NP_036474	Q13145	BAMBI_HUMAN	BMP and activin membrane-bound inhibitor	73	Extracellular (Potential).				cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|positive regulation of protein binding|positive regulation of transcription, DNA-dependent|regulation of cell shape	cytoplasm|integral to membrane|plasma membrane	frizzled binding|type II transforming growth factor beta receptor binding			central_nervous_system(4)	4						CCTGGACTCTCTTGCAAGCAC	0.498			NA											14	55					0	0	0.004007	0	0
BMS1	9790	broad.mit.edu	37	10	43318582	43318582	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:43318582C>T	uc001jaj.2	+	20	3507	c.3149C>T	c.(3148-3150)GCC>GTC	p.A1050V		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	1050					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						TTTAATTCTGCCTTGGAAGTG	0.413			NA											17	119					0	0	0.006122	0	0
ZNF22	7570	broad.mit.edu	37	10	45498928	45498928	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:45498928C>T	uc001jbw.2	+	2	355	c.112C>T	c.(112-114)CGA>TGA	p.R38*	C10orf25_uc010qff.1_5'Flank|C10orf25_uc001jbv.1_5'Flank|uc001jbx.1_RNA	NM_006963	NP_008894	P17026	ZNF22_HUMAN	zinc finger protein 22 (KOX 15)	38					odontogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|plasma membrane	DNA binding|zinc ion binding			breast(1)|kidney(1)	2		Prostate(175;0.0352)|all_neural(218;0.202)				CATGACTATTCGATTTGACTC	0.453			NA											8	61					0	0	0.00308	0	0
OGDHL	55753	broad.mit.edu	37	10	50944420	50944420	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:50944420T>C	uc001jie.2	-	21	2879	c.2737A>G	c.(2737-2739)ATC>GTC	p.I913V	OGDHL_uc009xog.2_Missense_Mutation_p.I940V|OGDHL_uc010qgt.1_Missense_Mutation_p.I856V|OGDHL_uc010qgu.1_Missense_Mutation_p.I704V	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	913					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						AGGCGCGTGATGGCCACTTTC	0.632			NA											14	74					0	0	0.003163	0	0
PCDH15	65217	broad.mit.edu	37	10	55569195	55569195	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:55569195T>A	uc010qhs.1	-	37	5025	c.4630A>T	c.(4630-4632)ACA>TCA	p.T1544S	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qht.1_Missense_Mutation_p.T1537S|PCDH15_uc010qhu.1_3'UTR	NM_001142769	NP_001136241	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD2-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CTCTTCCATGTTGTGTATGTA	0.403			NA								HNSCC(58;0.16)			20	146					0	0	0.008871	0	0
PCDH15	65217	broad.mit.edu	37	10	55600099	55600099	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:55600099C>T	uc001jju.1	-	29	4359	c.3964G>A	c.(3964-3966)GAT>AAT	p.D1322N	PCDH15_uc010qhq.1_Missense_Mutation_p.D1327N|PCDH15_uc010qhr.1_Missense_Mutation_p.D1322N|PCDH15_uc010qhs.1_Missense_Mutation_p.D1334N|PCDH15_uc010qht.1_Missense_Mutation_p.D1329N|PCDH15_uc010qhu.1_Missense_Mutation_p.D1322N|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.D1322N|PCDH15_uc010qhw.1_Missense_Mutation_p.D1285N|PCDH15_uc010qhx.1_Missense_Mutation_p.D1251N|PCDH15_uc010qhy.1_Missense_Mutation_p.D1327N|PCDH15_uc010qhz.1_Missense_Mutation_p.D1322N|PCDH15_uc010qia.1_Missense_Mutation_p.D1300N|PCDH15_uc010qib.1_Missense_Mutation_p.D1300N	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1322	Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TCATTTCTATCGATGGCTCTG	0.413			NA								HNSCC(58;0.16)			40	116					0	0	0.00874	0	0
PCDH15	65217	broad.mit.edu	37	10	55782676	55782676	+	Silent	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:55782676A>T	uc001jju.1	-	19	2897	c.2502T>A	c.(2500-2502)GCT>GCA	p.A834A	PCDH15_uc010qhq.1_Silent_p.A839A|PCDH15_uc010qhr.1_Silent_p.A834A|PCDH15_uc010qhs.1_Silent_p.A846A|PCDH15_uc010qht.1_Silent_p.A841A|PCDH15_uc010qhu.1_Silent_p.A834A|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Silent_p.A834A|PCDH15_uc010qhw.1_Silent_p.A797A|PCDH15_uc010qhx.1_Silent_p.A763A|PCDH15_uc010qhy.1_Silent_p.A839A|PCDH15_uc010qhz.1_Silent_p.A834A|PCDH15_uc010qia.1_Silent_p.A812A|PCDH15_uc010qib.1_Silent_p.A812A|PCDH15_uc001jjw.2_Silent_p.A834A	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	834	Extracellular (Potential).|Cadherin 8.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TGGTAGTCCCAGCTGGCAAAT	0.353			NA								HNSCC(58;0.16)			37	95					0	0	0.003214	0	0
IPMK	253430	broad.mit.edu	37	10	59956367	59956367	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:59956367C>G	uc001jkb.2	-	6	1044	c.721G>C	c.(721-723)GAA>CAA	p.E241Q		NM_152230	NP_689416	Q8NFU5	IPMK_HUMAN	inositol polyphosphate multikinase	241						nucleus	ATP binding|inositol trisphosphate 6-kinase activity			ovary(1)	1						TTCTGGTTTTCAAACCACTGC	0.363			NA											15	42					0	0	0.00245	0	0
PBLD	64081	broad.mit.edu	37	10	70048269	70048269	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:70048269C>A	uc001jns.1	-	8	865	c.662G>T	c.(661-663)TGG>TTG	p.W221L	PBLD_uc001jnr.1_Missense_Mutation_p.W188L|PBLD_uc001jnt.1_Missense_Mutation_p.W221L|PBLD_uc001jnu.1_Missense_Mutation_p.W221L|PBLD_uc001jnv.1_3'UTR	NM_022129	NP_071412	P30039	PBLD_HUMAN	MAWD binding protein isoform a	221					biosynthetic process		isomerase activity			skin(2)|ovary(1)	3						CACACCAACCCACGGTGCAAA	0.458			NA											7	47					0.00198382	0.00223792	0.001984	1	0
CDH23	64072	broad.mit.edu	37	10	73498295	73498295	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:73498295G>A	uc001jrx.3	+	33	4627	c.4250G>A	c.(4249-4251)CGG>CAG	p.R1417Q	C10orf105_uc001jsb.1_5'Flank|CDH23_uc001jsc.1_Missense_Mutation_p.R224Q	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	1417	Cadherin 13.|Extracellular (Potential).		R -> W.		calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						AACAGCCCCCGGTTTGACTTC	0.612			NA											7	33					0	0	0.004482	0	0
DLG5	9231	broad.mit.edu	37	10	79601669	79601669	+	Silent	SNP	C	C	A	rs138228867		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:79601669C>A	uc001jzk.2	-	7	1477	c.1407G>T	c.(1405-1407)GCG>GCT	p.A469A	DLG5_uc001jzj.2_Silent_p.A224A|DLG5_uc009xru.1_RNA|DLG5_uc001jzl.3_Silent_p.A73A	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	469					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CCTCATTGGCCGCCTTCTTCT	0.617			NA											6	46					0.00307968	0.00345283	0.00308	1	0
PLCE1	51196	broad.mit.edu	37	10	95993841	95993841	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:95993841C>A	uc001kjk.2	+	6	2620	c.1986C>A	c.(1984-1986)TTC>TTA	p.F662L	PLCE1_uc010qnx.1_Missense_Mutation_p.F662L|PLCE1_uc001kjm.2_Missense_Mutation_p.F354L	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	662	Ras-GEF.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				TGTGGCAGTTCATGGACCAGT	0.423			NA											9	43					7.48243e-07	1.02813e-06	0.006214	1	0
SORBS1	10580	broad.mit.edu	37	10	97144023	97144023	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:97144023G>A	uc001kkp.2	-	14	1425	c.1380C>T	c.(1378-1380)TAC>TAT	p.Y460Y	SORBS1_uc001kkk.2_Silent_p.Y38Y|SORBS1_uc001kkl.2_Silent_p.Y62Y|SORBS1_uc001kkn.2_Silent_p.Y247Y|SORBS1_uc001kkm.2_Silent_p.Y316Y|SORBS1_uc001kko.2_Silent_p.Y482Y|SORBS1_uc001kkq.2_Silent_p.Y345Y|SORBS1_uc001kkr.2_Silent_p.Y250Y|SORBS1_uc001kks.2_Silent_p.Y250Y|SORBS1_uc001kkt.2_RNA|SORBS1_uc001kku.2_Silent_p.Y291Y|SORBS1_uc001kkv.2_Silent_p.Y382Y|SORBS1_uc001kkw.2_Silent_p.Y414Y|SORBS1_uc010qoe.1_Silent_p.Y259Y|SORBS1_uc010qof.1_Silent_p.Y612Y	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	460	SoHo.				focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		ATCTGGGAGAGTACAGATCTG	0.428			NA											23	90					0	0	0.004656	0	0
HPSE2	60495	broad.mit.edu	37	10	100995424	100995424	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:100995424G>C	uc001kpn.1	-	1	196	c.136C>G	c.(136-138)CCC>GCC	p.P46A	HPSE2_uc009xwc.1_Missense_Mutation_p.P36A|HPSE2_uc001kpo.1_Missense_Mutation_p.P36A|HPSE2_uc009xwd.1_Missense_Mutation_p.P36A	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	46					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		ACAGGCAAGGGTCTCCTGTCT	0.572			NA											21	161					0	0	0.001882	0	0
SEC31B	25956	broad.mit.edu	37	10	102249088	102249088	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:102249088T>A	uc001krc.1	-	23	3194	c.3092A>T	c.(3091-3093)CAA>CTA	p.Q1031L	SEC31B_uc010qpo.1_Missense_Mutation_p.Q1030L|SEC31B_uc001krd.1_Missense_Mutation_p.Q568L|SEC31B_uc001krf.1_Missense_Mutation_p.Q463L|SEC31B_uc001kre.1_Missense_Mutation_p.Q463L	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	1031	Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		AAGAATCCCTTGTAGCTCAGG	0.522			NA											5	28					0	0	0.000602	0	0
SORCS1	114815	broad.mit.edu	37	10	108489838	108489838	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:108489838C>A	uc001kym.2	-	6	1002	c.994G>T	c.(994-996)GTG>TTG	p.V332L	SORCS1_uc001kyl.2_Missense_Mutation_p.V332L|SORCS1_uc009xxs.2_Missense_Mutation_p.V332L|SORCS1_uc001kyn.1_Missense_Mutation_p.V332L|SORCS1_uc001kyo.2_Missense_Mutation_p.V332L	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	332	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TCAAGATGCACAAGGTCTGGT	0.388			NA											4	52					4.096e-09	6.09812e-09	0.001168	1	0
NRAP	4892	broad.mit.edu	37	10	115374006	115374006	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:115374006G>T	uc001laj.2	-	29	3400	c.3236C>A	c.(3235-3237)TCC>TAC	p.S1079Y	NRAP_uc009xyb.2_Intron|NRAP_uc001lak.2_Missense_Mutation_p.S1044Y|NRAP_uc001lal.3_Missense_Mutation_p.S1079Y	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	1079	Nebulin 28.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CAAGCTCCGGGAACCAAGCAT	0.507			NA											18	187					1.00905e-13	1.70744e-13	0.008871	1	0
C10orf81	79949	broad.mit.edu	37	10	115531801	115531801	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:115531801G>A	uc001lat.1	+	7	1169	c.607G>A	c.(607-609)GTG>ATG	p.V203M	C10orf81_uc001lar.1_Missense_Mutation_p.V209M|C10orf81_uc009xyc.1_Missense_Mutation_p.V121M|C10orf81_uc001las.1_Missense_Mutation_p.V121M|C10orf81_uc001lau.1_Missense_Mutation_p.V23M	NM_024889	NP_079165	Q5SXH7	CJ081_HUMAN	hypothetical protein LOC79949	203										central_nervous_system(1)	1		Colorectal(252;0.175)		Epithelial(162;0.0181)|all cancers(201;0.0204)		CACTCAAGATGTGAAGGAAGA	0.323			NA											40	101					0	0	0.00874	0	0
C10orf118	55088	broad.mit.edu	37	10	115922587	115922587	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:115922587C>A	uc001lbb.1	-	2	1093	c.441G>T	c.(439-441)AAG>AAT	p.K147N	C10orf118_uc001lbc.1_Missense_Mutation_p.K147N|C10orf118_uc009xye.1_RNA|C10orf118_uc001lbd.2_Missense_Mutation_p.K147N|C10orf118_uc001lbe.2_Missense_Mutation_p.K147N	NM_018017	NP_060487	Q7Z3E2	CJ118_HUMAN	CTCL tumor antigen L14-2	147										ovary(2)	2		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0161)|all cancers(201;0.0397)		AAATAAATTTCTTGGTGCAGT	0.358			NA											18	134					8.28177e-16	1.4312e-15	0.007413	1	0
PNLIPRP3	119548	broad.mit.edu	37	10	118196236	118196236	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:118196236C>T	uc001lcl.3	+	2	164	c.63C>T	c.(61-63)TGC>TGT	p.C21C		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	21					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		AAGAAGTTTGCTATGAAAGGT	0.423			NA											13	104					0	0	0.00245	0	0
TACC2	10579	broad.mit.edu	37	10	123844295	123844295	+	Silent	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:123844295T>C	uc001lfv.2	+	4	2640	c.2280T>C	c.(2278-2280)GAT>GAC	p.D760D	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Silent_p.D760D|TACC2_uc010qtv.1_Silent_p.D760D	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	760						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CGTCCCCAGATCAACCCCGCG	0.607			NA											12	82					0	0	0.001855	0	0
CUZD1	50624	broad.mit.edu	37	10	124598650	124598650	+	Missense_Mutation	SNP	C	C	T	rs143659470		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:124598650C>T	uc001lgq.2	-	3	663	c.331G>A	c.(331-333)GAC>AAC	p.D111N	CUZD1_uc001lgp.2_5'Flank|CUZD1_uc009yad.2_5'Flank|CUZD1_uc009yaf.2_Intron|CUZD1_uc001lgr.2_5'UTR|CUZD1_uc010qty.1_5'UTR|CUZD1_uc009yae.2_5'UTR|CUZD1_uc001lgs.2_Missense_Mutation_p.D111N|CUZD1_uc010qtz.1_Missense_Mutation_p.D111N	NM_022034	NP_071317	Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1 precursor	111	CUB 1.|Extracellular (Potential).				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				ovary(1)|skin(1)	2		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		GGAACATAGTCGTTTTTACTG	0.408			NA											70	190					0	0	0.00361	0	0
FAM196A	642938	broad.mit.edu	37	10	128974033	128974033	+	Silent	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:128974033G>C	uc001lju.1	-	1	668	c.627C>G	c.(625-627)CTC>CTG	p.L209L	DOCK1_uc001ljt.2_Intron|DOCK1_uc010qun.1_Intron|FAM196A_uc010quo.1_Silent_p.L209L|FAM196A_uc001ljv.1_Silent_p.L209L|FAM196A_uc009yap.1_Silent_p.L209L	NM_001039762	NP_001034851	Q6ZSG2	F196A_HUMAN	hypothetical protein LOC642938	209										ovary(2)	2						TGGAGTTTTGGAGCGCAGCTT	0.612			NA											11	22					0	0	0.00245	0	0
DPYSL4	10570	broad.mit.edu	37	10	134013942	134013942	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr10:134013942C>A	uc009ybb.2	+	9	1048	c.894C>A	c.(892-894)GCC>GCA	p.A298A		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	298					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		GGGCCAAGGCCGCAGCCTTCG	0.652			NA											18	28					5.03518e-11	8.019e-11	0.007413	1	0
MUC5B	727897	broad.mit.edu	37	11	1271325	1271325	+	Silent	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:1271325T>A	uc009ycr.1	+	51	14760	c.14634T>A	c.(14632-14634)ACT>ACA	p.T4878T	MUC5B_uc001ltb.2_Silent_p.T4408T	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4405	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTGCAGCCACTGGCCCCACGG	0.652			NA											19	71					0	0	0.002299	0	0
OR52K2	119774	broad.mit.edu	37	11	4470602	4470602	+	Silent	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:4470602A>T	uc001lyz.1	+	1	33	c.33A>T	c.(31-33)CCA>CCT	p.P11P		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		TAACACATCCAACTGCCTTCT	0.493			NA											7	44					0	0	0.00308	0	0
OR51A7	119687	broad.mit.edu	37	11	4929527	4929527	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:4929527T>A	uc010qyq.1	+	1	928	c.928T>A	c.(928-930)TGT>AGT	p.C310S		NM_001004749	NP_001004749	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A,	310	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCTTAATGTATGTGGGAGATA	0.388			NA											7	50					0	0	0.00308	0	0
OR51L1	119682	broad.mit.edu	37	11	5021145	5021145	+	Silent	SNP	A	A	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:5021145A>G	uc010qyu.1	+	1	933	c.933A>G	c.(931-933)CTA>CTG	p.L311L		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	311	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGTTTGTCCTAAGGAGGAGGT	0.408			NA											12	52					0	0	0.000978	0	0
OR52A5	390054	broad.mit.edu	37	11	5152927	5152927	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:5152927T>A	uc010qyx.1	-	1	946	c.946A>T	c.(946-948)ACT>TCT	p.T316S		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	316	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		AACGATCAAGTTACTTTTTTG	0.348			NA											6	49					0	0	0.001168	0	0
OR51I1	390063	broad.mit.edu	37	11	5462206	5462206	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:5462206T>A	uc010qze.1	-	1	539	c.539A>T	c.(538-540)TAC>TTC	p.Y180F	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005288	NP_001005288	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGGAGACAGTAGGAGTGATG	0.448			NA											6	34					0	0	0.00308	0	0
OR56A3	390083	broad.mit.edu	37	11	5969356	5969356	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:5969356G>A	uc010qzt.1	+	1	780	c.780G>A	c.(778-780)CTG>CTA	p.L260L		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	260	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCATCCTTCTGGTTTTTGTCC	0.527			NA											25	124					0	0	0.004656	0	0
ZNF214	7761	broad.mit.edu	37	11	7021692	7021692	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:7021692G>A	uc001mfa.2	-	3	1525	c.1222C>T	c.(1222-1224)CAC>TAC	p.H408Y	ZNF214_uc010ray.1_Missense_Mutation_p.H408Y|ZNF214_uc009yfh.1_Missense_Mutation_p.H408Y	NM_013249	NP_037381	Q9UL59	ZN214_HUMAN	zinc finger protein 214	408	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		TCTCCTGTGTGTACTAACTGA	0.418	Ovarian(22;251 657 736 21522 46864)		NA											20	83					0	0	0.008871	0	0
IGSF22	283284	broad.mit.edu	37	11	18738526	18738526	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:18738526C>T	uc009yht.2	-	10	1185	c.995G>A	c.(994-996)GGA>GAA	p.G332E	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	332										ovary(4)|large_intestine(2)|kidney(1)	7						CTTCATCTCTCCCAGGAACTT	0.537			NA											4	49					0	0	0.009096	0	0
F2	2147	broad.mit.edu	37	11	46740807	46740807	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:46740807C>A	uc001ndf.3	+	1	65	c.22C>A	c.(22-24)CAG>AAG	p.Q8K	F2_uc001ndg.3_RNA	NM_000506	NP_000497	P00734	THRB_HUMAN	coagulation factor II preproprotein	8					activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity			ovary(3)	3		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	CCGAGGCTTGCAGCTGCCTGG	0.582	Esophageal Squamous(147;1147 1808 2148 38609 51144)		NA											3	22					1.024e-07	1.44228e-07	0.000602	1	0
OR4C6	219432	broad.mit.edu	37	11	55433224	55433224	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:55433224C>A	uc001nht.3	+	3	847	c.582C>A	c.(580-582)GGC>GGA	p.G194G	OR4C6_uc010rik.1_Silent_p.G194G	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	194	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						ACATCCTGGGCCTCTTAGTTA	0.443			NA											31	84					1.06801e-11	1.73493e-11	0.009535	1	0
OR5D13	390142	broad.mit.edu	37	11	55541472	55541472	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:55541472G>T	uc010ril.1	+	1	559	c.559G>T	c.(559-561)GTT>TTT	p.V187F		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				CTCTGTAATTGTTTCTGCCTC	0.383			NA											34	101					2.42023e-17	4.20235e-17	0.003271	1	0
OR5I1	10798	broad.mit.edu	37	11	55703126	55703126	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:55703126T>A	uc010ris.1	-	1	751	c.751A>T	c.(751-753)ACG>TCG	p.T251S		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGGTAGATCGTCACTGAAGTC	0.428			NA											3	30					0	0	0.009096	0	0
OR8H3	390152	broad.mit.edu	37	11	55890084	55890084	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:55890084C>G	uc001nii.1	+	1	236	c.236C>G	c.(235-237)ACA>AGA	p.T79R		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	79	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					ACTGTCGTCACACCTAAAACC	0.433			NA											47	413					0	0	0.00361	0	0
OR5J2	282775	broad.mit.edu	37	11	55944722	55944722	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:55944722C>G	uc010rjb.1	+	1	629	c.629C>G	c.(628-630)ACC>AGC	p.T210S		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					GCCATGGCCACCTTCTTGACT	0.473			NA											11	68					0	0	0.000978	0	0
OR5T1	390155	broad.mit.edu	37	11	56043396	56043397	+	Missense_Mutation	DNP	GG	GG	TT	rs113612396	byFrequency	TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:56043396_56043397GG>TT	uc001nio.1	+	1	282_283	c.282_283GG>TT	c.(280-285)TTGGTC>TTTTTC	p.94_95LV>FF		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	94_95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					CAAAAATGTTGGTCAATTTCCT	0.376			NA											32	101					0	0	0.004672	0	0
OR1S2	219958	broad.mit.edu	37	11	57970951	57970951	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:57970951T>C	uc010rkb.1	-	1	703	c.703A>G	c.(703-705)ATC>GTC	p.I235V		NM_001004459	NP_001004459	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				ACAGCTCTGATGATGCAGACA	0.438			NA											13	39					0	0	0.001368	0	0
OR10V1	390201	broad.mit.edu	37	11	59481191	59481191	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:59481191G>T	uc001nof.1	-	1	128	c.128C>A	c.(127-129)GCT>GAT	p.A43D		NM_001005324	NP_001005324	Q8NGI7	O10V1_HUMAN	olfactory receptor, family 10, subfamily V,	43	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGCAATTGTAGCATTTCCACC	0.443			NA											11	31					6.40141e-05	8.01272e-05	0.000978	1	0
TUT1	64852	broad.mit.edu	37	11	62358944	62358944	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:62358944T>C	uc001nto.2	-	1	166	c.128A>G	c.(127-129)GAT>GGT	p.D43G		NM_022830	NP_073741	Q9H6E5	STPAP_HUMAN	terminal uridylyl transferase 1, U6	5					mRNA cleavage|mRNA polyadenylation|snRNA processing	nuclear speck|nucleolus	ATP binding|enzyme binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|RNA uridylyltransferase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2						GACATCCGAATCCACCGCCGC	0.622			NA											7	34					0	0	0.00308	0	0
CHRM1	1128	broad.mit.edu	37	11	62677634	62677634	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:62677634G>A	uc001nwi.2	-	2	1340	c.939C>T	c.(937-939)GCC>GCT	p.A313A		NM_000738	NP_000729	P11229	ACM1_HUMAN	cholinergic receptor, muscarinic 1	313	Cytoplasmic (Potential).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell proliferation|nervous system development|positive regulation of cell proliferation|protein modification process	cell junction|integral to plasma membrane|membrane fraction|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity|protein binding				0					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Benztropine(DB00245)|Bethanechol(DB01019)|Biperiden(DB00810)|Buclizine(DB00354)|Carbachol(DB00411)|Carbinoxamine(DB00748)|Cevimeline(DB00185)|Clidinium(DB00771)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Cyclopentolate(DB00979)|Cycrimine(DB00942)|Desipramine(DB01151)|Dicyclomine(DB00804)|Diphenidol(DB01231)|Doxylamine(DB00366)|Ethopropazine(DB00392)|Flavoxate(DB01148)|Glycopyrrolate(DB00986)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methantheline(DB00940)|Methotrimeprazine(DB01403)|Methylscopolamine(DB00462)|Metixene(DB00340)|Metoclopramide(DB01233)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Oxyphenonium(DB00219)|Pilocarpine(DB01085)|Pirenzepine(DB00670)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propantheline(DB00782)|Propiomazine(DB00777)|Quinacrine(DB01103)|Scopolamine(DB00747)|Solifenacin(DB01591)|Succinylcholine(DB00202)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)|Trihexyphenidyl(DB00376)|Trospium(DB00209)	GCTTGGTGGGGGCCTGTGCCT	0.617			NA											6	76					0	0	0.001168	0	0
SPDYC	387778	broad.mit.edu	37	11	64940419	64940419	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:64940419G>A	uc010rnz.1	+	6	781	c.781G>A	c.(781-783)GGT>AGT	p.G261S		NM_001008778	NP_001008778	Q5MJ68	SPDYC_HUMAN	speedy C	261					cell cycle	nucleus	protein kinase binding				0						AAACGCCTGGGGTGGGGACTT	0.567			NA											11	75					0	0	0.000978	0	0
LRP5	4041	broad.mit.edu	37	11	68183797	68183797	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:68183797G>A	uc001ont.2	+	13	2904	c.2829G>A	c.(2827-2829)CCG>CCA	p.P943P	LRP5_uc009ysg.2_Silent_p.P353P	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	943	Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						CTCCTCTAGCGCCCACCACCT	0.602			NA											32	27					0	0	0.005524	0	0
PCF11	51585	broad.mit.edu	37	11	82893518	82893518	+	Silent	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:82893518T>C	uc001ozx.3	+	14	4746	c.4401T>C	c.(4399-4401)ATT>ATC	p.I1467I		NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	1467					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						AAAATGCTATTAGAGTAGATG	0.313			NA											11	30					0	0	0.008291	0	0
FAT3	120114	broad.mit.edu	37	11	92532295	92532295	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:92532295G>A	uc001pdj.3	+	9	6133	c.6116G>A	c.(6115-6117)GGA>GAA	p.G2039E		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2039	Extracellular (Potential).|Cadherin 18.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAGACGACTGGAGTCCCCTTT	0.483			NA								TCGA Ovarian(4;0.039)			9	40					0	0	0.004482	0	0
TMPRSS13	84000	broad.mit.edu	37	11	117787940	117787940	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:117787940C>A	uc001prs.1	-	3	594	c.501G>T	c.(499-501)CCG>CCT	p.P167P	TMPRSS13_uc009yzr.1_Intron|TMPRSS13_uc001prt.1_5'UTR|TMPRSS13_uc001pru.1_Silent_p.P167P	NM_001077263	NP_001070731	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	162	Helical; Signal-anchor for type II membrane protein; (Potential).				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			pancreas(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		ACCCGATGAGCGGTAGCTGCT	0.627			NA											12	16					0.00185496	0.00211871	0.001855	1	0
HMBS	3145	broad.mit.edu	37	11	118960402	118960402	+	Silent	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:118960402G>C	uc001puz.1	+	6	433	c.276G>C	c.(274-276)CTG>CTC	p.L92L	HMBS_uc009zao.1_Silent_p.L37L|HMBS_uc001pvc.1_Silent_p.L37L|HMBS_uc009zap.1_Silent_p.L75L|HMBS_uc001pva.1_Silent_p.L92L|HMBS_uc001pvb.1_Silent_p.L74L|HMBS_uc001pvd.1_Silent_p.L75L|HMBS_uc001pve.1_Silent_p.L75L|HMBS_uc001pvf.1_Silent_p.L75L	NM_000190	NP_000181	P08397	HEM3_HUMAN	hydroxymethylbilane synthase isoform 1	92			L -> P (in AIP).		peptidyl-pyrromethane cofactor linkage	cytosol	hydroxymethylbilane synthase activity				0	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.72e-05)		GAGTGGACCTGGTTGTTCACT	0.562			NA							Porphyria_Acute_Intermittent				15	15					0	0	0.004007	0	0
GRIK4	2900	broad.mit.edu	37	11	120776196	120776196	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:120776196C>T	uc001pxn.2	+	13	1757	c.1470C>T	c.(1468-1470)ATC>ATT	p.I490I	GRIK4_uc009zav.1_Silent_p.I490I|GRIK4_uc009zaw.1_Silent_p.I490I|GRIK4_uc009zax.1_Silent_p.I490I	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	490	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	GGGAGCTGATCGCTAGGGTAA	0.577			NA											27	83					0	0	0.004656	0	0
GRAMD1B	57476	broad.mit.edu	37	11	123471196	123471196	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:123471196G>T	uc001pyx.2	+	7	890	c.561G>T	c.(559-561)GGG>GGT	p.G187G	GRAMD1B_uc001pyw.2_Silent_p.G194G|GRAMD1B_uc010rzw.1_Silent_p.G147G|GRAMD1B_uc010rzx.1_Silent_p.G147G|GRAMD1B_uc009zbe.1_Silent_p.G183G	NM_020716	NP_065767	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	187						integral to membrane				ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		CTTCGTTTGGGGCCCGGGATA	0.418			NA											14	24					0.00074312	0.000863626	0.006122	1	0
OR8G2	26492	broad.mit.edu	37	11	124095992	124095992	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:124095992G>T	uc010saf.1	+	1	595	c.595G>T	c.(595-597)GGG>TGG	p.G199W		NM_001007249	NP_001007250	Q15614	OR8G2_HUMAN	olfactory receptor, family 8, subfamily G,	199						integral to membrane	olfactory receptor activity				0		Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.91e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		CCCTCTCTTGGGGCTCTCCTG	0.428			NA											5	249					0.000602214	0.000706611	0.000602	1	0
PTPN6	5777	broad.mit.edu	37	12	7064898	7064898	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:7064898C>T	uc001qsb.2	+	7	1065	c.823C>T	c.(823-825)CGC>TGC	p.R275C	PTPN6_uc001qsa.1_Missense_Mutation_p.R277C|PTPN6_uc010sfr.1_Missense_Mutation_p.R236C|PTPN6_uc009zfl.1_Missense_Mutation_p.R275C|PTPN6_uc010sfs.1_Missense_Mutation_p.R263C	NM_002831	NP_002822	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type	275	Tyrosine-protein phosphatase.				apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity			breast(1)	1						GGGCAAGAACCGCTACAAGAA	0.597			NA											7	20					0	0	0.001984	0	0
ATF7IP	55729	broad.mit.edu	37	12	14577856	14577856	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:14577856A>T	uc001rbw.2	+	2	1165	c.1007A>T	c.(1006-1008)GAT>GTT	p.D336V	ATF7IP_uc010shs.1_Missense_Mutation_p.D336V|ATF7IP_uc001rbu.2_Missense_Mutation_p.D336V|ATF7IP_uc001rbv.1_Missense_Mutation_p.D336V|ATF7IP_uc001rbx.2_Missense_Mutation_p.D336V|ATF7IP_uc010sht.1_Missense_Mutation_p.D336V|ATF7IP_uc001rby.3_Missense_Mutation_p.D336V|ATF7IP_uc001rbz.1_Missense_Mutation_p.D336V|ATF7IP_uc001rca.2_Missense_Mutation_p.D336V|ATF7IP_uc001rcb.2_5'Flank	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	336					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						GACTCATTGGATGAGAAAAAT	0.299			NA											26	42					0	0	0.003954	0	0
OVCH1	341350	broad.mit.edu	37	12	29648274	29648274	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:29648274C>A	uc001rix.1	-	4	398	c.398G>T	c.(397-399)CGT>CTT	p.R133L		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	133	Peptidase S1 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					CATATATTCACGGCTGTTGTA	0.373			NA											10	165					3.07112e-06	4.13441e-06	0.000978	1	0
AMN1	196394	broad.mit.edu	37	12	31862270	31862270	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:31862270A>C	uc001rkq.3	-	2	294	c.128T>G	c.(127-129)ATA>AGA	p.I43R	AMN1_uc001rko.3_Missense_Mutation_p.I25R|AMN1_uc010skc.1_Missense_Mutation_p.I25R|AMN1_uc001rkp.3_Missense_Mutation_p.I25R|AMN1_uc009zjs.2_Intron|AMN1_uc009zjt.1_Intron	NM_001113402	NP_001106873	Q8IY45	AMN1_HUMAN	antagonist of mitotic exit network 1 homolog	43											0	all_cancers(9;7.41e-12)|all_epithelial(9;1.18e-11)|all_lung(12;1.14e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.162)		OV - Ovarian serous cystadenocarcinoma(6;0.0014)			CATACTCATTATTTTAATCAG	0.328			NA											6	56					0	0	0.001984	0	0
C12orf35	55196	broad.mit.edu	37	12	32135455	32135455	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:32135455G>A	uc001rks.2	+	4	1980	c.1566G>A	c.(1564-1566)GTG>GTA	p.V522V		NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	522										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			CTCATGATGTGAAAGTTCTCA	0.393			NA											3	54					0	0	0.004672	0	0
ADCY6	112	broad.mit.edu	37	12	49172026	49172026	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:49172026C>A	uc001rsh.3	-	2	1539	c.879G>T	c.(877-879)GTG>GTT	p.V293V	ADCY6_uc001rsj.3_Silent_p.V293V|ADCY6_uc001rsi.3_Silent_p.V293V	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	293	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						GGAACAGCAGCACATTGGCAC	0.572			NA											6	42					0.00198382	0.00223792	0.001984	1	0
LARP4	113251	broad.mit.edu	37	12	50829370	50829370	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:50829370G>T	uc001rwp.1	+	5	642	c.498G>T	c.(496-498)TTG>TTT	p.L166F	LARP4_uc001rwo.1_Missense_Mutation_p.L172F|LARP4_uc001rwq.1_Missense_Mutation_p.L166F|LARP4_uc001rwr.1_Missense_Mutation_p.L166F|LARP4_uc001rws.1_Missense_Mutation_p.L165F|LARP4_uc009zlr.1_5'Flank|LARP4_uc001rwm.2_Missense_Mutation_p.L166F|LARP4_uc001rwn.2_Missense_Mutation_p.L96F	NM_052879	NP_443111	Q71RC2	LARP4_HUMAN	c-Mpl binding protein isoform a	166	HTH La-type RNA-binding.						nucleotide binding|RNA binding			ovary(1)	1						TAAAAAAGTTGACTACAGACC	0.299			NA											13	64					6.81908e-15	1.16739e-14	0.00245	1	0
KRT82	3888	broad.mit.edu	37	12	52799698	52799698	+	Nonsense_Mutation	SNP	C	C	A	rs145722634		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:52799698C>A	uc001sai.1	-	1	479	c.364G>T	c.(364-366)GAG>TAG	p.E122*		NM_033033	NP_149022	Q9NSB4	KRT82_HUMAN	keratin 82	122	Coil 1A.|Rod.					keratin filament	protein binding|structural constituent of epidermis			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.193)		TTGATCTGCTCCTTCTCATCC	0.567			NA											18	208					3.41278e-10	5.2743e-10	0.00499	1	0
KRT6A	3853	broad.mit.edu	37	12	52883764	52883764	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:52883764T>C	uc001sam.2	-	6	1375	c.1166A>G	c.(1165-1167)CAG>CGG	p.Q389R		NM_005554	NP_005545	P02538	K2C6A_HUMAN	keratin 6A	389	Rod.|Coil 2.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			ovary(4)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.189)		TCTCAGCCTCTGGATCATGCG	0.557			NA											10	27					0	0	0.004007	0	0
KRT73	319101	broad.mit.edu	37	12	53002076	53002077	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:53002076_53002077CC>AA	uc001sas.2	-	9	1561_1562	c.1526_1527GG>TT	c.(1525-1527)GGG>GTT	p.G509V		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	509	Tail.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		TCCTGGCTTCCCCACGGGGGCT	0.579			NA											7	73					0	0	0.004672	0	0
ZBTB39	9880	broad.mit.edu	37	12	57398575	57398575	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:57398575C>T	uc001sml.1	-	2	213	c.127G>A	c.(127-129)GCC>ACC	p.A43T	RDH16_uc010sqx.1_5'Flank	NM_014830	NP_055645	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	43	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1						GCCTTGTGGGCCGGGAAGGAG	0.582			NA											36	94					0	0	0.005524	0	0
LRIG3	121227	broad.mit.edu	37	12	59274658	59274658	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:59274658C>T	uc001sqr.2	-	13	1752	c.1506G>A	c.(1504-1506)ACG>ACA	p.T502T	LRIG3_uc009zqh.2_Silent_p.T442T|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	502	Ig-like C2-type 1.					integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			CTGGCTGAACCGTGATCTGGG	0.423			NA											17	142					0	0	0.008871	0	0
SRGAP1	57522	broad.mit.edu	37	12	64502733	64502733	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:64502733G>A	uc010ssp.1	+	16	1891	c.1835G>A	c.(1834-1836)AGG>AAG	p.R612K	SRGAP1_uc001srv.2_Missense_Mutation_p.R549K	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	612	Rho-GAP.				axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		CTCTATGAGAGGGCGCTTCAC	0.453			NA											4	87					0	0	0.009096	0	0
RAB3IP	117177	broad.mit.edu	37	12	70209151	70209151	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:70209151G>T	uc001svp.2	+	11	1803	c.1356G>T	c.(1354-1356)CAG>CAT	p.Q452H	RAB3IP_uc001svm.2_Missense_Mutation_p.Q436H|RAB3IP_uc001svn.2_3'UTR|RAB3IP_uc001svo.2_RNA|RAB3IP_uc001svq.2_3'UTR|RAB3IP_uc001svr.2_RNA|RAB3IP_uc001svs.2_RNA|RAB3IP_uc001svt.2_Missense_Mutation_p.Q230H	NM_175623	NP_783322	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein isoform alpha 2	452					cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			TAGTTGATCAGATGTTTTGGG	0.358			NA											25	68					2.44723e-14	4.15064e-14	0.004656	1	0
PTPRB	5787	broad.mit.edu	37	12	70954551	70954551	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:70954551C>A	uc001swb.3	-	15	3708	c.3678G>T	c.(3676-3678)GAG>GAT	p.E1226D	PTPRB_uc010sto.1_Missense_Mutation_p.E1136D|PTPRB_uc010stp.1_Missense_Mutation_p.E1136D|PTPRB_uc001swc.3_Missense_Mutation_p.E1444D|PTPRB_uc001swa.3_Missense_Mutation_p.E1356D|PTPRB_uc001swd.3_Missense_Mutation_p.E1443D|PTPRB_uc009zrr.1_Missense_Mutation_p.E1323D	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1226	Fibronectin type-III 14.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GAAACCGCCACTCCGTCAGGT	0.493			NA											17	34					1.02788e-11	1.67346e-11	0.00499	1	0
PTPRB	5787	broad.mit.edu	37	12	70960398	70960398	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:70960398C>A	uc001swb.3	-	13	3097	c.3067G>T	c.(3067-3069)GCA>TCA	p.A1023S	PTPRB_uc010sto.1_Intron|PTPRB_uc010stp.1_Missense_Mutation_p.A933S|PTPRB_uc001swc.3_Missense_Mutation_p.A1241S|PTPRB_uc001swa.3_Missense_Mutation_p.A1153S|PTPRB_uc001swd.3_Missense_Mutation_p.A1240S|PTPRB_uc009zrr.1_Missense_Mutation_p.A1120S	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1023	Fibronectin type-III 12.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TATCTTTCTGCCACACCAGCA	0.423			NA											22	66					5.35356e-11	8.47067e-11	0.00278	1	0
PTPRB	5787	broad.mit.edu	37	12	71029809	71029809	+	Silent	SNP	A	A	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:71029809A>G	uc001swc.3	-	2	137	c.93T>C	c.(91-93)TGT>TGC	p.C31C	PTPRB_uc001swa.3_Silent_p.C31C|PTPRB_uc001swd.3_Silent_p.C30C|PTPRB_uc009zrr.1_Silent_p.C31C|PTPRB_uc001swe.2_Silent_p.C31C	NM_001109754	NP_001103224	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	Error:Variant_position_missing_in_P23467_after_alignment					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TTTTGAAAAGACACTGTTGTT	0.423			NA											4	20					0	0	0.009096	0	0
SLC6A15	55117	broad.mit.edu	37	12	85285811	85285811	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:85285811G>T	uc001szv.2	-	2	582	c.89C>A	c.(88-90)GCT>GAT	p.A30D	SLC6A15_uc010sul.1_Intron|SLC6A15_uc001szy.2_Missense_Mutation_p.A30D	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	30	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity	p.A30T(1)		pancreas(2)|ovary(1)	3						AGCATCATCAGCTGCGTCTTC	0.398			NA											22	190					5.26018e-13	8.69953e-13	0.001882	1	0
LUM	4060	broad.mit.edu	37	12	91497992	91497992	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:91497992G>T	uc001tbm.2	-	3	1356	c.967C>A	c.(967-969)CCG>ACG	p.P323T	LUM_uc001tbn.2_RNA	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	323	LRR 11.				collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)	2						TACATATCCGGTGGAAGACTG	0.403			NA											15	53					0.00400662	0.00447152	0.004007	1	0
SCYL2	55681	broad.mit.edu	37	12	100732925	100732925	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:100732925A>T	uc001thn.2	+	18	2815	c.2765A>T	c.(2764-2766)AAT>ATT	p.N922I		NM_017988	NP_060458	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 protein	922	Necessary for interaction with AP2 complex and clathrin, interaction with clathrin is necessary for its targeting to the TGN and endosomal membranes.				endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			lung(3)|ovary(2)|skin(1)	6						TCAGCTAGCAATGATTTAAAA	0.368			NA											15	100					0	0	0.003163	0	0
TXNRD1	7296	broad.mit.edu	37	12	104705135	104705135	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:104705135A>G	uc010swk.1	+	5	504	c.482A>G	c.(481-483)TAT>TGT	p.Y161C	TXNRD1_uc010swl.1_Missense_Mutation_p.Y11C|TXNRD1_uc010swm.1_Missense_Mutation_p.Y63C|TXNRD1_uc010swn.1_Missense_Mutation_p.Y11C|TXNRD1_uc010swo.1_Missense_Mutation_p.Y11C|TXNRD1_uc010swp.1_Intron|TXNRD1_uc010swq.1_Missense_Mutation_p.Y61C|TXNRD1_uc001tku.2_RNA|TXNRD1_uc009zun.2_Missense_Mutation_p.Y77C|TXNRD1_uc001tko.1_RNA|TXNRD1_uc001tkp.1_RNA|TXNRD1_uc001tkv.1_RNA	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	161					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						CCCAAGTCCTATGACTATGAC	0.438	Ovarian(139;555 1836 9186 9946 10884)		NA											5	11					0	0	0.000602	0	0
ALDH1L2	160428	broad.mit.edu	37	12	105428127	105428127	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:105428127C>G	uc001tlc.2	-	19	2322	c.2195G>C	c.(2194-2196)GGG>GCG	p.G732A	ALDH1L2_uc009zuo.2_Missense_Mutation_p.G187A|ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	732	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						GAACAACCGCCCAGCAGCAAT	0.418			NA											5	20					0	0	0.001984	0	0
CCDC63	160762	broad.mit.edu	37	12	111318979	111318979	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:111318979G>A	uc001trv.1	+	7	927	c.732G>A	c.(730-732)CAG>CAA	p.Q244Q	CCDC63_uc009zvt.1_Missense_Mutation_p.V99I|CCDC63_uc010sye.1_Silent_p.Q204Q|CCDC63_uc001trw.1_Silent_p.Q159Q	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	244	Potential.									skin(6)|ovary(1)|pancreas(1)	8						ACACCTCTCAGTACAACCTGG	0.557			NA											10	25					0	0	0.006214	0	0
TBX5	6910	broad.mit.edu	37	12	114803991	114803991	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:114803991A>C	uc001tvo.2	-	8	1456	c.961T>G	c.(961-963)TAC>GAC	p.Y321D	TBX5_uc001tvp.2_Missense_Mutation_p.Y321D|TBX5_uc001tvq.2_Missense_Mutation_p.Y271D|TBX5_uc010syv.1_Missense_Mutation_p.Y321D	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	321					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		GTACAATGGTAAATTTGGCTA	0.542	NSCLC(152;1358 1980 4050 23898 40356)		NA											13	34					0	0	0.00245	0	0
TAOK3	51347	broad.mit.edu	37	12	118671547	118671547	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:118671547G>C	uc001twx.2	-	9	870	c.575C>G	c.(574-576)GCT>GGT	p.A192G	TAOK3_uc001tww.2_Missense_Mutation_p.A22G|TAOK3_uc001twy.3_Missense_Mutation_p.A192G	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	192	Protein kinase.				MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTCATCCATAGCTAAGATCAC	0.353			NA											12	109					0	0	0.001855	0	0
NCOR2	9612	broad.mit.edu	37	12	124817745	124817745	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:124817745G>A	uc010tay.1	-	44	6872	c.6716C>T	c.(6715-6717)ACG>ATG	p.T2239M	NCOR2_uc010taz.1_Missense_Mutation_p.T2223M|NCOR2_uc010tax.1_Missense_Mutation_p.T350M	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 1	2240					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CCCTGGCTCCGTCATGCCCTC	0.642			NA											8	24					0	0	0.00308	0	0
RIMBP2	23504	broad.mit.edu	37	12	130963548	130963548	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:130963548G>T	uc001uil.2	-	3	175	c.11C>A	c.(10-12)GCG>GAG	p.A4E	RIMBP2_uc001uim.2_5'UTR	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	4						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CCGTTCAGCCGCCTCTCGCAT	0.617			NA											9	25					3.86212e-05	4.90993e-05	0.008291	1	0
RNF17	56163	broad.mit.edu	37	13	25341431	25341431	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr13:25341431G>A	uc001upr.2	+	2	193	c.152G>A	c.(151-153)TGT>TAT	p.C51Y	RNF17_uc010tdd.1_Translation_Start_Site|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.C51Y|RNF17_uc001ups.2_Translation_Start_Site|RNF17_uc001upq.1_Missense_Mutation_p.C51Y	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	51	RING-type.				multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		GAACTTCAATGTGGACATGCT	0.259			NA											8	91					0	0	0.00308	0	0
FLT3	2322	broad.mit.edu	37	13	28626770	28626770	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr13:28626770T>C	uc001urw.2	-	5	608	c.526A>G	c.(526-528)ATG>GTG	p.M176V	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.M176V	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	176	Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGGTTTTCCATTTTTCTAAAG	0.408			NA	Mis|O		AML|ALL								12	58					0	0	0.00245	0	0
MTUS2	23281	broad.mit.edu	37	13	29599371	29599371	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr13:29599371G>A	uc001usl.3	+	1	624	c.566G>A	c.(565-567)AGA>AAA	p.R189K		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	179						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						TCTTTGGAAAGAGCAAGCAGC	0.547			NA											6	55					0	0	0.001168	0	0
STARD13	90627	broad.mit.edu	37	13	33739517	33739517	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr13:33739517C>T	uc001uuw.2	-	3	406	c.280G>A	c.(280-282)GAT>AAT	p.D94N	STARD13_uc001uuu.2_Missense_Mutation_p.D86N|STARD13_uc001uuv.2_5'UTR|STARD13_uc001uux.2_Missense_Mutation_p.D59N|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Missense_Mutation_p.D79N	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	94	SAM.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		AAATCATGATCATTCTTGACA	0.368			NA											8	56					0	0	0.004482	0	0
FAM48A	55578	broad.mit.edu	37	13	37593535	37593535	+	Splice_Site	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr13:37593535C>A	uc001uwg.2	-	22	2065	c.1817_splice	c.e22-1	p.G606_splice	FAM48A_uc010abt.2_Splice_Site_p.G607_splice|FAM48A_uc001uwh.2_Splice_Site_p.G607_splice|FAM48A_uc001uwi.2_Splice_Site_p.G606_splice|FAM48A_uc001uwj.2_Splice_Site_p.G607_splice|FAM48A_uc001uwk.2_Splice_Site_p.G685_splice|FAM48A_uc001uwd.2_Splice_Site_p.G93_splice|FAM48A_uc001uwe.2_Splice_Site_p.G90_splice|FAM48A_uc001uwf.2_Splice_Site_p.G184_splice	NM_001014286	NP_001014308	Q8NEM7	FA48A_HUMAN	family with sequence similarity 48, member A						autophagy|gastrulation	SAGA-type complex	protein binding				0		Lung NSC(96;2.09e-06)|Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.0959)		all cancers(112;6.06e-07)|Epithelial(112;1.87e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00794)|BRCA - Breast invasive adenocarcinoma(63;0.0128)|GBM - Glioblastoma multiforme(144;0.0477)		AATGGAACACCTGTTAAATAA	0.254			NA											15	89					0.00400662	0.00447152	0.004007	1	0
NHLRC3	387921	broad.mit.edu	37	13	39616394	39616394	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr13:39616394G>A	uc001uxc.2	+	4	860	c.538G>A	c.(538-540)GTG>ATG	p.V180M	NHLRC3_uc001uxb.1_Missense_Mutation_p.V180M|NHLRC3_uc001uxd.2_Intron|NHLRC3_uc001uxe.2_Translation_Start_Site	NM_001012754	NP_001012772	Q5JS37	NHLC3_HUMAN	NHL repeat containing 3 isoform a	180	NHL 2.					extracellular region				skin(1)	1		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;2.37e-08)|Epithelial(112;3.14e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00101)|BRCA - Breast invasive adenocarcinoma(63;0.00335)|GBM - Glioblastoma multiforme(144;0.0128)		TATTTACATTGTGGATGGAGA	0.328			NA											14	83					0	0	0.004007	0	0
FNDC3A	22862	broad.mit.edu	37	13	49771970	49771970	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr13:49771970A>T	uc001vcm.2	+	21	2755	c.2450A>T	c.(2449-2451)AAA>ATA	p.K817I	FNDC3A_uc001vcn.2_Missense_Mutation_p.K817I|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcq.2_Missense_Mutation_p.K761I	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	817	Fibronectin type-III 6.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		TATGAAATAAAAGGACTTTCA	0.408			NA											17	47					0	0	0.00499	0	0
TDRD3	81550	broad.mit.edu	37	13	61059946	61059946	+	Missense_Mutation	SNP	A	A	G	rs17855091		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr13:61059946A>G	uc001via.2	+	7	1090	c.302A>G	c.(301-303)CAT>CGT	p.H101R	TDRD3_uc010aef.2_5'UTR|TDRD3_uc001vhz.3_Missense_Mutation_p.H101R|TDRD3_uc010aeg.2_Missense_Mutation_p.H194R|TDRD3_uc001vib.3_Missense_Mutation_p.H100R	NM_030794	NP_110421	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3 isoform 2	101				H -> R (in Ref. 6; AAH60876).	chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		TGTGTATCTCATGTCCAAGTG	0.323	Colon(36;164 906 35820 50723)		NA											8	23					0	0	0.006214	0	0
KLHL1	57626	broad.mit.edu	37	13	70370930	70370930	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr13:70370930T>A	uc001vip.2	-	7	2373	c.1579A>T	c.(1579-1581)AAT>TAT	p.N527Y	KLHL1_uc010thm.1_Missense_Mutation_p.N466Y	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	527	Kelch 2.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		GTTTTGGGATTGTAACATTCA	0.388			NA											10	66					0	0	0.006214	0	0
SLITRK5	26050	broad.mit.edu	37	13	88327942	88327943	+	Missense_Mutation	DNP	AG	AG	TA			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	AG	AG	-	-	AG	AG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr13:88327942_88327943AG>TA	uc001vln.2	+	2	518_519	c.299_300AG>TA	c.(298-300)GAG>GTA	p.E100V	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	100	LRR 1.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					TATCCCAATGAGTTTGTCAATT	0.485			NA											29	159					0	0	0.004672	0	0
MCF2L	23263	broad.mit.edu	37	13	113718714	113718714	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr13:113718714C>T	uc001vsu.2	+	6	779	c.757C>T	c.(757-759)CGG>TGG	p.R253W	MCF2L_uc001vsq.2_Missense_Mutation_p.R253W|MCF2L_uc010tjr.1_Missense_Mutation_p.R196W|MCF2L_uc001vsr.2_Missense_Mutation_p.R200W|MCF2L_uc001vss.3_Missense_Mutation_p.R194W|MCF2L_uc010tjs.1_Missense_Mutation_p.R194W|MCF2L_uc001vst.1_Missense_Mutation_p.R158W	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	226					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				CTGCCACTCCCGGTGGCTGTG	0.607			NA											4	32					0	0	0.009096	0	0
POTEG	404785	broad.mit.edu	37	14	19553587	19553587	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:19553587C>A	uc001vuz.1	+	1	223	c.171C>A	c.(169-171)CTC>CTA	p.L57L	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	57										ovary(1)	1						TGAAGACACTCAGGAGCAAGA	0.617			NA											16	343					3.01185e-09	4.49319e-09	0.003954	1	0
P704P	641455	broad.mit.edu	37	14	20020050	20020050	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:20020050G>T	uc001vwc.3	-	1	223	c.171C>A	c.(169-171)CTC>CTA	p.L57L	P704P_uc001vwb.3_RNA	NM_001145442	NP_001138914	A6NI47	POTEM_HUMAN	prostate-specific P704P	57											0						TCTTGCTCCTGAGTGTCTTCA	0.617			NA											14	178					0.000308642	0.000369864	0.003163	1	0
OR4N2	390429	broad.mit.edu	37	14	20295661	20295661	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:20295661C>A	uc010tkv.1	+	1	54	c.54C>A	c.(52-54)ACC>ACA	p.T18T		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTGGTCTGACCCAGTCTCAAG	0.383			NA											16	178					2.48551e-13	4.16721e-13	0.00499	1	0
OR4K14	122740	broad.mit.edu	37	14	20482705	20482705	+	Silent	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:20482705C>G	uc010tky.1	-	1	648	c.648G>C	c.(646-648)CTG>CTC	p.L216L		NM_001004712	NP_001004712	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		TGTAGGAGATCAGGAGGAGCA	0.502			NA											3	11					0	0	0.004672	0	0
OR4K17	390436	broad.mit.edu	37	14	20586056	20586056	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:20586056T>A	uc001vwo.1	+	1	491	c.491T>A	c.(490-492)ATG>AAG	p.M164K		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CTACACTACATGACCATCATG	0.448			NA											19	81					0	0	0.007413	0	0
OR4N5	390437	broad.mit.edu	37	14	20612048	20612048	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:20612048G>T	uc010tla.1	+	1	154	c.154G>T	c.(154-156)GAC>TAC	p.D52Y		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		CATAAAGTCAGACCCTGGGCT	0.463			NA											44	256					2.64894e-19	4.67724e-19	0.00361	1	0
OR11H4	390442	broad.mit.edu	37	14	20711524	20711524	+	Missense_Mutation	SNP	G	G	T	rs142588807	by1000genomes	TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:20711524G>T	uc010tld.1	+	1	574	c.574G>T	c.(574-576)GAC>TAC	p.D192Y		NM_001004479	NP_001004479	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H,	192	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		GTGTGACATGGACCCATTGAT	0.433			NA											23	132					2.32416e-17	4.0548e-17	0.002299	1	0
PARP2	10038	broad.mit.edu	37	14	20820432	20820432	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:20820432G>A	uc001vxc.2	+	7	593	c.565G>A	c.(565-567)GAA>AAA	p.E189K	PARP2_uc001vxd.2_Missense_Mutation_p.E176K|PARP2_uc001vxb.1_Missense_Mutation_p.E189K|PARP2_uc010tle.1_5'Flank	NM_005484	NP_005475	Q9UGN5	PARP2_HUMAN	poly (ADP-ribose) polymerase family, member 2	189					protein ADP-ribosylation	nucleolus|nucleoplasm	DNA binding|NAD+ ADP-ribosyltransferase activity			ovary(1)|pancreas(1)	2	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;5.34e-07)|all cancers(55;3.7e-06)	GBM - Glioblastoma multiforme(265;0.00888)|READ - Rectum adenocarcinoma(17;0.0649)		AAACAATTGGGAAGATCGAGA	0.368			NA						Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					9	58					0	0	0.004482	0	0
CBLN3	643866	broad.mit.edu	37	14	24897532	24897532	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:24897532C>T	uc001wpg.3	-	2	851	c.380G>A	c.(379-381)CGG>CAG	p.R127Q	KHNYN_uc010tpc.1_5'Flank|KHNYN_uc001wph.3_5'Flank|KHNYN_uc010alw.2_5'Flank	NM_001039771	NP_001034860	Q6UW01	CBLN3_HUMAN	cerebellin 3 precursor	127	Necessary for interaction with CBLN3, and homotrimerization (By similarity).|C1q.					cell junction|extracellular region|synapse				central_nervous_system(1)	1				GBM - Glioblastoma multiforme(265;0.00159)		CACATGGAACCGGAAGCTGTA	0.647			NA											31	108					0	0	0.008361	0	0
NOVA1	4857	broad.mit.edu	37	14	26917372	26917372	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:26917372T>A	uc001wpy.2	-	5	1635	c.1317A>T	c.(1315-1317)AAA>AAT	p.K439N	NOVA1_uc001wpz.2_Missense_Mutation_p.K415N|NOVA1_uc001wqa.2_Missense_Mutation_p.K317N	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	442	KH 3.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		TTTTCCCTCCTTTGCCAAGTA	0.443			NA											3	38					0	0	0.009096	0	0
FOXG1	2290	broad.mit.edu	37	14	29237307	29237307	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:29237307G>T	uc001wqe.2	+	1	1021	c.822G>T	c.(820-822)CGG>CGT	p.R274R		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	274	Fork-head.			Missing (in Ref. 1; CAA52240 and 2; CAA55038).	axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		GCAAGCTGCGGCGCCGCTCCA	0.701			NA											4	19					3.59834e-05	4.59055e-05	0.001168	1	0
FOXG1	2290	broad.mit.edu	37	14	29237327	29237327	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:29237327G>C	uc001wqe.2	+	1	1041	c.842G>C	c.(841-843)CGG>CCG	p.R281P		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	281				R -> P (in Ref. 1; CAA52239/CAA52240 and 2; CAA55038).	axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		ACCACCTCGCGGGCCAAGCTG	0.701			NA											5	22					0	0	0.000602	0	0
FRMD6	122786	broad.mit.edu	37	14	52188791	52188791	+	Silent	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:52188791A>T	uc001wzd.2	+	12	1770	c.1485A>T	c.(1483-1485)GGA>GGT	p.G495G	FRMD6_uc001wzb.2_Silent_p.G487G|FRMD6_uc001wzc.2_Silent_p.G487G|FRMD6_uc001wze.2_Silent_p.G418G|FRMD6_uc001wzf.2_Silent_p.G188G|FRMD6_uc001wzg.2_Silent_p.G137G	NM_152330	NP_689543	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	495						cytoskeleton|mitochondrion|plasma membrane	binding			ovary(1)|breast(1)|central_nervous_system(1)	3	all_epithelial(31;0.0163)|Breast(41;0.089)					AGCTGAATGGACACTCTGGTG	0.507			NA											10	35					0	0	0.000978	0	0
NID2	22795	broad.mit.edu	37	14	52505683	52505683	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:52505683G>C	uc001wzo.2	-	9	2273	c.2039C>G	c.(2038-2040)ACA>AGA	p.T680R	NID2_uc010tqs.1_Missense_Mutation_p.T680R|NID2_uc010tqt.1_Missense_Mutation_p.T680R|NID2_uc001wzp.2_Missense_Mutation_p.T680R	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	680	Nidogen G2 beta-barrel.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					TCTGGAACTTGTAGAGGTCAC	0.418			NA											7	38					0	0	0.001984	0	0
HIF1A	3091	broad.mit.edu	37	14	62199167	62199167	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:62199167G>T	uc001xfq.2	+	7	1209	c.805G>T	c.(805-807)GAA>TAA	p.E269*	HIF1A_uc001xfr.2_Nonsense_Mutation_p.E269*|HIF1A_uc001xfs.2_Nonsense_Mutation_p.E270*	NM_001530	NP_001521	Q16665	HIF1A_HUMAN	hypoxia-inducible factor 1, alpha subunit	269	PAS 2.|Interaction with TSGA10 (By similarity).				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			kidney(3)|lung(1)	4				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)		TGAGCCAGAAGAACTTTTAGG	0.338			NA											16	135					1.33834e-09	2.02552e-09	0.007413	1	0
TDP1	55775	broad.mit.edu	37	14	90429941	90429942	+	Missense_Mutation	DNP	GA	GA	TT			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:90429941_90429942GA>TT	uc001xxy.2	+	3	782_783	c.483_484GA>TT	c.(481-486)GGGAAC>GGTTAC	p.N162Y	TDP1_uc010atm.2_RNA|TDP1_uc001xxz.2_Missense_Mutation_p.N162Y|TDP1_uc010atn.2_Missense_Mutation_p.N162Y|TDP1_uc001xya.2_5'UTR|TDP1_uc001xyb.2_RNA|TDP1_uc010ato.2_Missense_Mutation_p.N162Y|TDP1_uc001xyc.1_Missense_Mutation_p.N162Y	NM_018319	NP_060789	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	162					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		TGGATAAAGGGAACCCCTTCCA	0.52			NA						Repair_of_DNA-protein_crosslinks					9	43					0	0	0.004672	0	0
TRIP11	9321	broad.mit.edu	37	14	92491728	92491728	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:92491728C>T	uc001xzy.2	-	3	1026	c.238G>A	c.(238-240)GAG>AAG	p.E80K		NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	80	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TCATGTTTCTCTTCTAGATCA	0.303	Ovarian(84;609 1888 9852 42686)		NA	T	PDGFRB	AML								5	41					0	0	0.000602	0	0
KIAA1409	57578	broad.mit.edu	37	14	94088672	94088672	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:94088672C>A	uc001ybv.1	+	28	4711	c.4628C>A	c.(4627-4629)TCT>TAT	p.S1543Y	KIAA1409_uc001ybs.1_Missense_Mutation_p.S1521Y	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1698						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GACTTTTCTTCTAAGGACTCA	0.537			NA											15	63					7.93312e-07	1.08598e-06	0.00245	1	0
DICER1	23405	broad.mit.edu	37	14	95562968	95562968	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:95562968C>A	uc001ydw.2	-	24	4471	c.4289G>T	c.(4288-4290)AGG>ATG	p.R1430M	DICER1_uc010avh.1_Missense_Mutation_p.R328M|DICER1_uc001ydv.2_Missense_Mutation_p.R1420M|DICER1_uc001ydx.2_Missense_Mutation_p.R1430M|DICER1_uc001ydy.1_Missense_Mutation_p.R282M	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1430					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		CTTCGGAGCCCTCCACATCAG	0.393			NA	Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				4	28					0.00909568	0.00987956	0.009096	1	0
TDRD9	122402	broad.mit.edu	37	14	104508469	104508469	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:104508469C>A	uc001yom.3	+	34	3949	c.3919C>A	c.(3919-3921)CTT>ATT	p.L1307I	TDRD9_uc001yon.3_Missense_Mutation_p.L854I	NM_153046	NP_694591	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	1307					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				ATGCAAGTGTCTTGGGCCAGA	0.458			NA											13	42					0.00185496	0.00211871	0.001855	1	0
AHNAK2	113146	broad.mit.edu	37	14	105411259	105411259	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:105411259G>T	uc010axc.1	-	7	10649	c.10529C>A	c.(10528-10530)TCC>TAC	p.S3510Y	AHNAK2_uc001ypx.2_Missense_Mutation_p.S3410Y	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3510						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTGCATGGAGGAGAGGCTCAC	0.637			NA											12	116					3.27435e-08	4.68405e-08	0.00245	1	0
C15orf2	23742	broad.mit.edu	37	15	24922632	24922632	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr15:24922632A>C	uc001ywo.2	+	1	2092	c.1618A>C	c.(1618-1620)ACC>CCC	p.T540P		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	540					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TTCCACCGGGACCTCAGTTAT	0.527			NA											28	140					0	0	0.002096	0	0
CHRNA7	1139	broad.mit.edu	37	15	32393544	32393544	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr15:32393544G>T	uc001zft.2	+	3	306	c.234G>T	c.(232-234)CTG>CTT	p.L78L	CHRNA7_uc010bab.1_Silent_p.L78L|CHRNA7_uc010bac.1_Silent_p.L78L|CHRNA7_uc010bad.1_RNA|CHRNA7_uc010bae.1_RNA|CHRNA7_uc010baf.2_5'UTR|CHRNA7_uc010bag.1_RNA|CHRNA7_uc010bah.1_RNA	NM_000746	NP_000737	P36544	ACHA7_HUMAN	cholinergic receptor, nicotinic, alpha 7	78	Extracellular (Potential).				activation of MAPK activity|calcium ion transport|cellular calcium ion homeostasis|memory|negative regulation of tumor necrosis factor production|positive regulation of angiogenesis|positive regulation of cell proliferation|response to hypoxia|response to nicotine	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|beta-amyloid binding|chloride channel regulator activity|nicotinic acetylcholine-activated cation-selective channel activity|protein homodimerization activity|toxin binding			ovary(1)	1		all_lung(180;6.35e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)	Nicotine(DB00184)|Varenicline(DB01273)	ACATTTGGCTGCAAATGGTAA	0.378	Esophageal Squamous(193;529 2900 40232 43193)		NA											20	105					1.2644e-06	1.7244e-06	0.010504	1	0
ZNF770	54989	broad.mit.edu	37	15	35275448	35275448	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr15:35275448G>A	uc001ziw.2	-	3	499	c.188C>T	c.(187-189)ACC>ATC	p.T63I		NM_014106	NP_054825	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	63	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)		TTGTCTAAAGGTTTTATGACA	0.338			NA											8	74					0	0	0.006214	0	0
TYRO3	7301	broad.mit.edu	37	15	41865602	41865602	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr15:41865602G>T	uc001zof.1	+	17	2306	c.2082G>T	c.(2080-2082)CTG>CTT	p.L694L		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	694	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		CCTCCAAACTGCCTGTCAAGT	0.592			NA											27	168					2.27525e-19	4.03692e-19	0.003954	1	0
STRC	161497	broad.mit.edu	37	15	43901484	43901484	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr15:43901484T>A	uc001zsf.2	-	16	3625	c.3547A>T	c.(3547-3549)AGG>TGG	p.R1183W	STRC_uc010bdl.2_Missense_Mutation_p.R410W|STRC_uc001zse.2_5'UTR	NM_153700	NP_714544	Q7RTU9	STRC_HUMAN	stereocilin precursor	1183					sensory perception of sound	cell surface					0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		TGCAGATTCCTGAGGGTAAGG	0.348			NA											14	80					0	0	0.003163	0	0
MFAP1	4236	broad.mit.edu	37	15	44097385	44097385	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr15:44097385C>T	uc001zth.1	-	9	1411	c.1227G>A	c.(1225-1227)GAG>GAA	p.E409E		NM_005926	NP_005917	P55081	MFAP1_HUMAN	microfibrillar-associated protein 1	409						microfibril				skin(1)	1		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.33e-07)		TCTGGGCACTCTCTTGGCCCC	0.443			NA											8	71					0	0	0.00308	0	0
NOX5	79400	broad.mit.edu	37	15	69328113	69328113	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr15:69328113C>G	uc002ars.1	+	7	1045	c.1025C>G	c.(1024-1026)GCG>GGG	p.A342G	NOX5_uc002arp.1_Missense_Mutation_p.A324G|NOX5_uc002arq.1_Missense_Mutation_p.A296G|NOX5_uc010bid.1_Missense_Mutation_p.A307G|NOX5_uc002arr.1_Missense_Mutation_p.A314G|NOX5_uc010bie.1_Missense_Mutation_p.A142G|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	342	Extracellular (Potential).|Ferric oxidoreductase.				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						CAGGCTCAGGCGGAGGCCAGC	0.612			NA											4	50					0	0	0.00308	0	0
NEO1	4756	broad.mit.edu	37	15	73552647	73552647	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr15:73552647G>T	uc002avm.3	+	15	2381	c.2239G>T	c.(2239-2241)GTA>TTA	p.V747L	NEO1_uc010ukx.1_Missense_Mutation_p.V747L|NEO1_uc010uky.1_Missense_Mutation_p.V747L|NEO1_uc010ukz.1_Missense_Mutation_p.V171L|NEO1_uc002avn.3_Missense_Mutation_p.V412L	NM_002499	NP_002490	Q92859	NEO1_HUMAN	neogenin homolog 1 precursor	747	Extracellular (Potential).|Fibronectin type-III 4.				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				pancreas(1)	1						CTCTCTTCACGTACGCCCGCT	0.478			NA											10	50					2.80697e-09	4.19611e-09	0.000978	1	0
HCN4	10021	broad.mit.edu	37	15	73617434	73617434	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr15:73617434C>G	uc002avp.2	-	6	2834	c.1840G>C	c.(1840-1842)GAG>CAG	p.E614Q		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	614	Cytoplasmic (Potential).|cAMP.				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		TGGAAGACCTCGAAACGCAGC	0.552			NA											7	68					0	0	0.00308	0	0
GOLGA6A	342096	broad.mit.edu	37	15	74373006	74373006	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr15:74373006T>G	uc002axa.1	-	2	196	c.155A>C	c.(154-156)GAC>GCC	p.D52A		NM_001038640	NP_001033729	Q9NYA3	GOG6A_HUMAN	golgi autoantigen, golgin subfamily a, 6	52	Potential.										0						AGGGCTACTGTCAGTTTTTTT	0.507			NA											4	63					0	0	0.001984	0	0
SEMA7A	8482	broad.mit.edu	37	15	74709697	74709697	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr15:74709697T>G	uc002axv.2	-	6	680	c.640A>C	c.(640-642)ACC>CCC	p.T214P	SEMA7A_uc010ulk.1_Missense_Mutation_p.T49P|SEMA7A_uc010ull.1_Missense_Mutation_p.T200P	NM_003612	NP_003603	O75326	SEM7A_HUMAN	semaphorin 7A isoform 1 preproprotein	214	Sema.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(1)|central_nervous_system(1)	2						GTATCACTGGTGTACAGCTCA	0.587			NA											17	77					0	0	0.007413	0	0
SEMA7A	8482	broad.mit.edu	37	15	74709982	74709982	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr15:74709982C>A	uc002axv.2	-	5	540	c.500G>T	c.(499-501)AGA>ATA	p.R167I	SEMA7A_uc010ulk.1_Missense_Mutation_p.R2I|SEMA7A_uc010ull.1_Missense_Mutation_p.R153I	NM_003612	NP_003603	O75326	SEM7A_HUMAN	semaphorin 7A isoform 1 preproprotein	167	Sema.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(1)|central_nervous_system(1)	2						GGCGTAGCCTCTCATCTCGCC	0.617			NA											7	26					1.12685e-05	1.47621e-05	0.004482	1	0
GOLGA6D	653643	broad.mit.edu	37	15	75586718	75586718	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr15:75586718G>A	uc010uma.1	+	18	2019	c.1984G>A	c.(1984-1986)GTG>ATG	p.V662M	uc010umd.1_5'Flank	NM_001145224	NP_001138696	P0CG33	GOG6D_HUMAN	golgi autoantigen, golgin subfamily a, 6D	662											0						GGACAACAACGTGGAGCCTGC	0.612			NA											4	39					0	0	0.009096	0	0
UBE2Q2	92912	broad.mit.edu	37	15	76168549	76168549	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr15:76168549C>T	uc002bbg.2	+	6	996	c.610C>T	c.(610-612)CAA>TAA	p.Q204*	UBE2Q2_uc002bbh.2_Nonsense_Mutation_p.Q169*|UBE2Q2_uc010umn.1_Nonsense_Mutation_p.Q188*|UBE2Q2_uc002bbi.2_Nonsense_Mutation_p.Q85*	NM_173469	NP_775740	Q8WVN8	UB2Q2_HUMAN	ubiquitin-conjugating enzyme E2Q 2 isoform 1	204					protein K48-linked ubiquitination	cytoplasm	ATP binding|ubiquitin-protein ligase activity			ovary(2)	2						TGGGTCAGTGCAAGCTTCAGA	0.408			NA											55	230					0	0	0.00361	0	0
SV2B	9899	broad.mit.edu	37	15	91835638	91835638	+	Silent	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr15:91835638T>C	uc002bqv.2	+	12	2299	c.1908T>C	c.(1906-1908)TTT>TTC	p.F636F	SV2B_uc010uqv.1_Silent_p.F485F|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	636	Helical; (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			TATGCAAATTTGGCGCCATCC	0.468			NA											13	94					0	0	0.001855	0	0
WDR24	84219	broad.mit.edu	37	16	739444	739444	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr16:739444C>T	uc002ciz.1	-	1	957	c.197G>A	c.(196-198)CGT>CAT	p.R66H		NM_032259	NP_115635	Q96S15	WDR24_HUMAN	WD repeat domain 24	128										ovary(1)|central_nervous_system(1)	2		Hepatocellular(780;0.0218)				GCGCCCCACACGCAGGTTCAG	0.597			NA											5	19					0	0	0.000602	0	0
TMC5	79838	broad.mit.edu	37	16	19475097	19475097	+	Splice_Site	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr16:19475097G>T	uc002dgc.3	+	8	1986	c.1237_splice	c.e8-1	p.A413_splice	TMC5_uc010vaq.1_Splice_Site_p.A413_splice|TMC5_uc002dgb.3_Splice_Site_p.A413_splice|TMC5_uc010var.1_Splice_Site_p.A413_splice|TMC5_uc002dgd.1_Splice_Site_p.A167_splice|TMC5_uc002dge.3_Splice_Site_p.A167_splice|TMC5_uc002dgf.3_Splice_Site_p.A96_splice|TMC5_uc002dgg.3_Splice_Site_p.A54_splice	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a							integral to membrane				skin(1)	1						CCTGATTCCAGGCTTATCGGA	0.413			NA											10	95					3.07112e-06	4.13441e-06	0.000978	1	0
PDILT	204474	broad.mit.edu	37	16	20380924	20380924	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr16:20380924C>A	uc002dhc.1	-	8	1229	c.1006G>T	c.(1006-1008)GTC>TTC	p.V336F		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	336					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						AGGATTTGGACGGATGGGATA	0.468			NA											19	140					2.4624e-09	3.69612e-09	0.008871	1	0
ACSM2B	348158	broad.mit.edu	37	16	20554527	20554527	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr16:20554527G>A	uc002dhj.3	-	12	1549	c.1339C>T	c.(1339-1341)CGG>TGG	p.R447W	ACSM2B_uc002dhk.3_Missense_Mutation_p.R447W|ACSM2B_uc010bwf.1_Missense_Mutation_p.R447W	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	447					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						TTGATTCCCCGGTCTCCAAGG	0.498			NA											27	169					0	0	0.005443	0	0
ACSM2B	348158	broad.mit.edu	37	16	20566759	20566759	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr16:20566759G>T	uc002dhj.3	-	5	638	c.428C>A	c.(427-429)ACT>AAT	p.T143N	ACSM2B_uc002dhk.3_Missense_Mutation_p.T143N|ACSM2B_uc010bwf.1_Missense_Mutation_p.T143N	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	143				T -> A (in Ref. 1; AAO17576).	fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						CAGTATGTCAGTGGATTTCAT	0.438			NA											7	79					6.40141e-05	8.01272e-05	0.000978	1	0
ERN2	10595	broad.mit.edu	37	16	23718184	23718184	+	Splice_Site	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr16:23718184T>A	uc002dma.3	-	6	693	c.524_splice	c.e6-1	p.G175_splice	ERN2_uc010bxp.2_Splice_Site_p.G175_splice|ERN2_uc010bxq.1_Splice_Site	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2						apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GCTTCCGGCCTGTGGAGGTGG	0.587			NA											6	23					0	0	0.001168	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29907150	29907150	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr16:29907150T>A	uc002duq.3	-	4	783	c.543A>T	c.(541-543)GAA>GAT	p.E181D	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.E111D|SEZ6L2_uc002dur.3_Missense_Mutation_p.E111D|SEZ6L2_uc002dus.3_Intron|SEZ6L2_uc010vec.1_Missense_Mutation_p.E181D|SEZ6L2_uc010ved.1_Missense_Mutation_p.E137D	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	181	CUB 1.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						CCACATACCCTTCGCCCTCGG	0.562			NA											11	68					0	0	0.001368	0	0
TRIM72	493829	broad.mit.edu	37	16	31234185	31234185	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr16:31234185C>A	uc002ebn.1	+	6	1007	c.778C>A	c.(778-780)CGT>AGT	p.R260S		NM_001008274	NP_001008275	Q6ZMU5	TRI72_HUMAN	tripartite motif-containing 72	260					exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding				0						CCCACCCGCCCGTCTGGACAT	0.617			NA											8	92					4.36969e-10	6.7106e-10	0.001855	1	0
ZNF267	10308	broad.mit.edu	37	16	31927756	31927756	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr16:31927756C>T	uc002ecs.3	+	4	2395	c.2186C>T	c.(2185-2187)TCA>TTA	p.S729L		NM_003414	NP_003405	Q14586	ZN267_HUMAN	zinc finger protein 267	729	C2H2-type 15.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						AACTCTAGGTCATACCTCATT	0.388			NA											13	89					0	0	0.003163	0	0
C16orf78	123970	broad.mit.edu	37	16	49433159	49433159	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr16:49433159G>T	uc002efr.2	+	5	811	c.768G>T	c.(766-768)GTG>GTT	p.V256V		NM_144602	NP_653203	Q8WTQ4	CP078_HUMAN	hypothetical protein LOC123970	256										central_nervous_system(1)	1						CTAAAAAGGTGTTCACCGGAA	0.517			NA											8	37					5.18039e-06	6.91034e-06	0.00308	1	0
SLC6A2	6530	broad.mit.edu	37	16	55730144	55730144	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr16:55730144C>A	uc002eif.2	+	9	1266	c.1155C>A	c.(1153-1155)GGC>GGA	p.G385G	SLC6A2_uc010ccd.2_Silent_p.G385G|SLC6A2_uc002eig.2_Silent_p.G385G|SLC6A2_uc002eih.2_Silent_p.G385G|SLC6A2_uc002eii.2_Silent_p.G280G|SLC6A2_uc002eij.2_Silent_p.G99G	NM_001043	NP_001034	P23975	SC6A2_HUMAN	solute carrier family 6 member 2	385					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			lung(4)|ovary(2)|pancreas(2)	8				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	CAGGAGCTGGCCTAGTGTTCA	0.512			NA											13	89					7.03913e-09	1.03118e-08	0.001368	1	0
CES1	1066	broad.mit.edu	37	16	55844547	55844547	+	Silent	SNP	G	G	T	rs145477234		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr16:55844547G>T	uc002eim.2	-	11	1305	c.1197C>A	c.(1195-1197)GCC>GCA	p.A399A	CES1_uc010ccf.2_Silent_p.A74A|CES1_uc002eil.2_Silent_p.A400A|CES1_uc002ein.2_Silent_p.A398A	NM_001025194	NP_001020365	P23141	EST1_HUMAN	carboxylesterase 1 isoform b precursor	399					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	ATTTCTCAGTGGCTTCTGGAA	0.478	NSCLC(162;1801 2756 42904 52896)		NA											18	158					2.94398e-08	4.21971e-08	0.007413	1	0
CPNE2	221184	broad.mit.edu	37	16	57144694	57144694	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr16:57144694G>T	uc002eks.1	+	2	269	c.40G>T	c.(40-42)GCA>TCA	p.A14S	CPNE2_uc010cct.1_Missense_Mutation_p.A40S|CPNE2_uc010ccu.1_Missense_Mutation_p.A14S	NM_152727	NP_689940	Q96FN4	CPNE2_HUMAN	copine II	14	C2 1.									central_nervous_system(1)|skin(1)	2		all_neural(199;0.224)				AGCAGCGGGGGCAGCCCCCAT	0.642			NA											8	64					5.18039e-06	6.91034e-06	0.00308	1	0
CDH11	1009	broad.mit.edu	37	16	65016031	65016031	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr16:65016031T>A	uc002eoi.2	-	8	1607	c.1173A>T	c.(1171-1173)GAA>GAT	p.E391D	CDH11_uc010cdn.2_Intron|CDH11_uc002eoj.2_Missense_Mutation_p.E391D|CDH11_uc010vin.1_Missense_Mutation_p.E265D|CDH11_uc002eok.1_RNA	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	391	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TTTCTTGGACTTCGTGGATGT	0.498			NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			23	86					0	0	0.00333	0	0
CDH5	1003	broad.mit.edu	37	16	66429973	66429973	+	Missense_Mutation	SNP	G	G	A	rs139755397	byFrequency	TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr16:66429973G>A	uc002eom.3	+	8	1385	c.1229G>A	c.(1228-1230)CGC>CAC	p.R410H		NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	410	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		TACTCCATCCGCAGGACCAGT	0.498			NA											6	46					0	0	0.00308	0	0
TMED6	146456	broad.mit.edu	37	16	69377433	69377433	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr16:69377433G>A	uc002exc.1	-	4	633	c.600C>T	c.(598-600)TAC>TAT	p.Y200Y		NM_144676	NP_653277	Q8WW62	TMED6_HUMAN	transmembrane emp24 protein transport domain	200	Lumenal (Potential).				transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1						ACCAGTTCACGTAGTTATAGT	0.418			NA											22	98					0	0	0.00333	0	0
CDH13	1012	broad.mit.edu	37	16	83711897	83711897	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr16:83711897G>T	uc002fgx.2	+	10	1489	c.1369G>T	c.(1369-1371)GGC>TGC	p.G457C	CDH13_uc010vns.1_Missense_Mutation_p.G504C|CDH13_uc010vnt.1_Missense_Mutation_p.G203C|CDH13_uc010vnu.1_Missense_Mutation_p.G418C	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	457	Cadherin 3.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		CGTCTCCTACGGCCCCAGCTC	0.557			NA											8	32					1.06961e-07	1.49787e-07	0.00308	1	0
SPNS3	201305	broad.mit.edu	37	17	4349456	4349456	+	Silent	SNP	C	C	T	rs146044768		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:4349456C>T	uc002fxt.2	+	4	560	c.516C>T	c.(514-516)CGC>CGT	p.R172R	SPNS3_uc002fxu.2_Silent_p.R45R	NM_182538	NP_872344	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3	172					lipid transport|transmembrane transport	integral to membrane				large_intestine(1)	1						AGCGCACCCGCGTGCTGGCTG	0.617			NA											8	51					0	0	0.008291	0	0
CLDN7	1366	broad.mit.edu	37	17	7164150	7164150	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:7164150G>A	uc002gfm.3	-	2	811	c.378C>T	c.(376-378)TTC>TTT	p.F126F	CLDN7_uc010cmc.2_Silent_p.F126F|CLDN7_uc002gfn.3_Silent_p.F126F	NM_001307	NP_001298	O95471	CLD7_HUMAN	claudin 7	126	Helical; (Potential).				calcium-independent cell-cell adhesion	integral to membrane|lateral plasma membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1						CTGCCACGATGAAAATTATGC	0.577			NA											11	60					0	0	0.00245	0	0
SPEM1	374768	broad.mit.edu	37	17	7324723	7324723	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:7324723G>T	uc002ggv.2	+	3	754	c.729G>T	c.(727-729)CTG>CTT	p.L243L	FGF11_uc010vtw.1_Intron	NM_199339	NP_955371	Q8N4L4	SPEM1_HUMAN	spermatid maturation 1	243					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|integral to membrane					0		Prostate(122;0.173)				CTCCCACCCTGGGCCCAGCAG	0.662			NA											11	27					6.40141e-05	8.01272e-05	0.000978	1	0
TP53	7157	broad.mit.edu	37	17	7578290	7578290	+	Splice_Site	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:7578290C>A	uc002gim.2	-	6	754	c.560_splice	c.e6-1	p.G187_splice	TP53_uc002gig.1_Splice_Site_p.G187_splice|TP53_uc002gih.2_Splice_Site_p.G187_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Splice_Site_p.G55_splice|TP53_uc010cng.1_Splice_Site_p.G55_splice|TP53_uc002gii.1_Splice_Site_p.G55_splice|TP53_uc010cnh.1_Splice_Site_p.G187_splice|TP53_uc010cni.1_Splice_Site_p.G187_splice|TP53_uc002gij.2_Splice_Site_p.G187_splice|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Splice_Site_p.G94_splice|TP53_uc002gio.2_Splice_Site_p.G55_splice|TP53_uc010vug.1_Intron	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(24)|p.0?(7)|p.G187fs*16(2)|p.D186_P191delDGLAPP(1)|p.L188fs*19(1)|p.G187_L188delGL(1)|p.G187fs*22(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGGCCAGACCTAAGAGCAAT	0.552	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	23					1.12685e-05	1.47621e-05	0.004482	1	0
TP53	7157	broad.mit.edu	37	17	7578457	7578457	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:7578457C>A	uc002gim.2	-	5	667	c.473G>T	c.(472-474)CGC>CTC	p.R158L	TP53_uc002gig.1_Missense_Mutation_p.R158L|TP53_uc002gih.2_Missense_Mutation_p.R158L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R26L|TP53_uc010cng.1_Missense_Mutation_p.R26L|TP53_uc002gii.1_Missense_Mutation_p.R26L|TP53_uc010cnh.1_Missense_Mutation_p.R158L|TP53_uc010cni.1_Missense_Mutation_p.R158L|TP53_uc002gij.2_Missense_Mutation_p.R158L|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R65L|TP53_uc002gio.2_Missense_Mutation_p.R26L|TP53_uc010vug.1_Missense_Mutation_p.R119L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	158	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158H(58)|p.R158L(55)|p.R158C(17)|p.R158G(10)|p.R158P(9)|p.0?(7)|p.R158R(6)|p.R158fs*12(5)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R158fs*11(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R158fs*24(1)|p.R65L(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.R26L(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCATGGCGCGGACGCGGGT	0.627	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			4	48					0.00909568	0.00987956	0.009096	1	0
DNAH2	146754	broad.mit.edu	37	17	7673701	7673701	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:7673701C>T	uc002giu.1	+	24	4087	c.4073C>T	c.(4072-4074)GCA>GTA	p.A1358V		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1358	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TCTGCTTCAGCAACTAAAGAG	0.527			NA											7	45					0	0	0.001984	0	0
PER1	5187	broad.mit.edu	37	17	8047130	8047130	+	Silent	SNP	T	T	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:8047130T>G	uc002gkd.2	-	19	2764	c.2526A>C	c.(2524-2526)TCA>TCC	p.S842S	PER1_uc010cns.2_5'Flank|PER1_uc010vuq.1_Intron	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	842	Nuclear localization signal (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						GGTGGTGGCGTGAGCGCTTGG	0.677			NA	T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					4	56					0	0	0.001168	0	0
MYH8	4626	broad.mit.edu	37	17	10303865	10303865	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:10303865C>A	uc002gmm.2	-	27	3672	c.3577G>T	c.(3577-3579)GCT>TCT	p.A1193S	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1193	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						CGAAGAGCAGCCACCATAGCT	0.542			NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				14	77					1.05317e-09	1.60056e-09	0.00245	1	0
MEIS3P1	4213	broad.mit.edu	37	17	15690727	15690727	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:15690727C>A	uc002gpc.2	+	1	564	c.543C>A	c.(541-543)TTC>TTA	p.F181L		NR_002211				RecName: Full=Homeobox protein Meis3; AltName: Full=Meis1-related protein 2;												0						CCTGGTTGTTCCAGCACCTCT	0.567			NA											12	47					7.03913e-09	1.03118e-08	0.001368	1	0
Unknown	0	broad.mit.edu	37	17	21731274	21731274	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:21731274C>A	uc002gyy.3	+	2	701	c.576C>A	c.(574-576)AGC>AGA	p.S192R						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;												NA						CCCCGATCAGCAGAGGCTCAT	0.552			NA											6	37					8.12818e-05	0.000100707	0.001984	1	0
Unknown	0	broad.mit.edu	37	17	21731278	21731278	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:21731278G>A	uc002gyy.3	+	2	705	c.580G>A	c.(580-582)GGC>AGC	p.G194S						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;												NA						GATCAGCAGAGGCTCATCTTT	0.547			NA											4	42					0	0	0.009096	0	0
SUPT6H	6830	broad.mit.edu	37	17	27000440	27000440	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:27000440C>T	uc002hby.2	+	2	111	c.21C>T	c.(19-21)AGC>AGT	p.S7S	SUPT6H_uc010crt.2_Silent_p.S7S	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	7	Asp/Glu-rich.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					TTGTGGAAAGCGAGGCTGAGG	0.468			NA											5	26					0	0	0.000602	0	0
EVI2B	2124	broad.mit.edu	37	17	29631504	29631504	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:29631504G>T	uc002hgk.2	-	2	1279	c.1124C>A	c.(1123-1125)CCA>CAA	p.P375Q	NF1_uc002hgg.2_Intron|NF1_uc002hgh.2_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.2_Intron|EVI2B_uc010csq.2_Missense_Mutation_p.P390Q	NM_006495	NP_006486	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B precursor	375	Cytoplasmic (Potential).					cytoplasm|integral to plasma membrane				ovary(2)	2		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		GTCCAGAGATGGAGGGAGACT	0.438			NA											13	127					9.05144e-12	1.47692e-11	0.001855	1	0
C17orf102	400591	broad.mit.edu	37	17	32905960	32905960	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:32905960C>G	uc002hie.1	-	1	429	c.340G>C	c.(340-342)GTG>CTG	p.V114L	TMEM132E_uc002hif.2_5'Flank	NM_207454	NP_997337	A2RUQ5	CQ102_HUMAN	hypothetical protein LOC400591	114										ovary(1)	1						AGGTTTCCCACAGCTGCGCCC	0.602			NA											23	148					0	0	0.001882	0	0
ACACA	31	broad.mit.edu	37	17	35486404	35486404	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:35486404T>A	uc002hnm.2	-	47	5911	c.5720A>T	c.(5719-5721)CAC>CTC	p.H1907L	ACACA_uc002hnk.2_Missense_Mutation_p.H1829L|ACACA_uc002hnl.2_Missense_Mutation_p.H1849L|ACACA_uc002hnn.2_Missense_Mutation_p.H1907L|ACACA_uc002hno.2_Missense_Mutation_p.H1944L|ACACA_uc010cuy.2_Missense_Mutation_p.H552L|ACACA_uc010wdc.1_Missense_Mutation_p.H33L	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1907	Carboxyltransferase.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	AACTGAACTGTGCACGCTCTA	0.478	Colon(23;82 258 739 2117 10493 24037 27661 34815 35438 36249)		NA											6	32					0	0	0.001984	0	0
KRTAP4-4	84616	broad.mit.edu	37	17	39316534	39316534	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:39316534T>G	uc002hwc.2	-	1	450	c.410A>C	c.(409-411)CAG>CCG	p.Q137P		NM_032524	NP_115913	Q9BYR3	KRA44_HUMAN	keratin associated protein 4.4	137	23.|26 X 5 AA repeats of C-C-[GRQVCH]-[SPT]- [VSTQR].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			GCAGGTGGTCTGGCAGCACTG	0.647			NA											5	42					0	0	0.00308	0	0
KRTAP4-3	85290	broad.mit.edu	37	17	39324300	39324300	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:39324300G>T	uc010cxl.2	-	1	125	c.125C>A	c.(124-126)CCC>CAC	p.P42H		NM_033187	NP_149443	Q9BYR4	KRA43_HUMAN	keratin associated protein 4-3	42	29 X 5 AA repeats of C-C-[GIKRQVH]-[SPT]- [STA].|2.					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			gcagcagctggggcggcagca	0.294			NA											4	23					0.00024832	0.000299541	0.009096	1	0
KRT38	8687	broad.mit.edu	37	17	39594374	39594374	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:39594374G>T	uc002hwq.1	-	6	1635	c.1212C>A	c.(1210-1212)TAC>TAA	p.Y404*		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	404	Coil 2.|Rod.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				GAAGGTTCCGGTACGTGGCAA	0.547			NA											9	39					4.68919e-08	6.66887e-08	0.008291	1	0
STAT5B	6777	broad.mit.edu	37	17	40359680	40359680	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:40359680T>C	uc002hzh.2	-	16	2142	c.1973A>G	c.(1972-1974)GAC>GGC	p.D658G		NM_012448	NP_036580	P51692	STA5B_HUMAN	signal transducer and activator of transcription	658	SH2.				2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			ovary(3)|lung(2)|skin(1)	6		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	TCCCAAGCGGTCGGCTAGGGA	0.433			NA											9	77					0	0	0.004482	0	0
COASY	80347	broad.mit.edu	37	17	40716788	40716788	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:40716788G>A	uc002hzz.2	+	5	1266	c.1109G>A	c.(1108-1110)GGG>GAG	p.G370E	COASY_uc010cyj.2_Missense_Mutation_p.G399E|COASY_uc002iab.2_Missense_Mutation_p.G75E|COASY_uc002iad.2_Missense_Mutation_p.G370E|COASY_uc002iac.2_Missense_Mutation_p.G370E|COASY_uc002iae.2_Missense_Mutation_p.G165E|MLX_uc002iaf.2_5'Flank|MLX_uc002iag.2_5'Flank|MLX_uc002iah.2_5'Flank	NM_001042529	NP_001035994	Q13057	COASY_HUMAN	coenzyme A synthase isoform a	370	DPCK.|ATP (Potential).				coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial outer membrane	ATP binding|dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity				0		all_cancers(22;1.06e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)		AGTGGCTCTGGGAAGAGCTCA	0.587			NA											22	116					0	0	0.001882	0	0
CNTNAP1	8506	broad.mit.edu	37	17	40835871	40835871	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:40835871T>C	uc002iay.2	+	2	316	c.100T>C	c.(100-102)TAT>CAT	p.Y34H	CCR10_uc002iax.3_5'Flank|CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	34	Extracellular (Potential).|F5/8 type C.				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		GGGTCCCCTGTATGCACGCTC	0.642			NA											8	31					0	0	0.006214	0	0
DHX8	1659	broad.mit.edu	37	17	41561531	41561531	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:41561531G>T	uc002idu.1	+	1	199	c.126G>T	c.(124-126)TTG>TTT	p.L42F	DHX8_uc010wif.1_5'UTR|DHX8_uc010wig.1_Missense_Mutation_p.L42F	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	42						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		ACAATCACTTGGGGATCAACG	0.567	NSCLC(56;1548 1661 49258 49987)		NA									OREG0024434	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	79					9.8876e-21	1.76289e-20	0.004878	1	0
HOXB3	3213	broad.mit.edu	37	17	46628225	46628225	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:46628225G>T	uc002inn.2	-	2	1167	c.767C>A	c.(766-768)TCG>TAG	p.S256*	HOXB3_uc010wlm.1_Nonsense_Mutation_p.S183*|HOXB3_uc010dbf.2_Nonsense_Mutation_p.S256*|HOXB3_uc010dbg.2_Nonsense_Mutation_p.S256*|HOXB3_uc002ino.2_Nonsense_Mutation_p.S256*|HOXB3_uc010wlk.1_Nonsense_Mutation_p.S124*|HOXB3_uc010wll.1_Nonsense_Mutation_p.S183*	NM_002146	NP_002137	P14651	HXB3_HUMAN	homeobox B3	256					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TGGGCCCCCCGACGACGAGGC	0.632			NA									OREG0024516	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	88					3.93418e-24	7.10095e-24	0.004289	1	0
CLTC	1213	broad.mit.edu	37	17	57762458	57762458	+	Silent	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:57762458T>C	uc002ixq.1	+	29	4919	c.4476T>C	c.(4474-4476)AAT>AAC	p.N1492N	CLTC_uc002ixp.2_Silent_p.N1492N|CLTC_uc002ixr.1_Silent_p.N1496N	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	1492	Heavy chain arm.|Proximal segment.|Involved in binding clathrin light chain (By similarity).				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					ACTTTGACAATATCTCGCTTG	0.378			NA	T	ALK|TFE3	ALCL|renal 								4	170					0	0	0.009096	0	0
TMEM49	81671	broad.mit.edu	37	17	57917156	57917156	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:57917156G>C	uc002ixu.3	+	12	1378	c.1105G>C	c.(1105-1107)GAA>CAA	p.E369Q	TMEM49_uc010wog.1_Missense_Mutation_p.E177Q|TMEM49_uc010woh.1_Missense_Mutation_p.E313Q|TMEM49_uc010woi.1_Missense_Mutation_p.E272Q|TMEM49_uc010woj.1_Missense_Mutation_p.E235Q|TMEM49_uc002ixv.2_RNA|MIR21_hsa-mir-21|MI0000077_5'Flank	NM_030938	NP_112200	Q96GC9	VMP1_HUMAN	transmembrane protein 49	369	Helical; (Potential).				autophagy|cell adhesion	endoplasmic reticulum|ER-Golgi intermediate compartment membrane|integral to membrane|plasma membrane|vacuolar membrane					0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;1.15e-09)|all cancers(12;1.15e-08)			CTGGATGTTTGAAAAGTTGGT	0.388			NA											39	382					0	0	0.00874	0	0
BCAS3	54828	broad.mit.edu	37	17	58786659	58786659	+	Silent	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:58786659T>C	uc002iyv.3	+	5	403	c.294T>C	c.(292-294)AGT>AGC	p.S98S	BCAS3_uc010wow.1_Intron|BCAS3_uc002iyu.3_Silent_p.S98S|BCAS3_uc002iyw.3_Silent_p.S94S	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	98	WD 1.					nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			TTGGCTACAGTGATGGAATGC	0.373			NA											30	57					0	0	0.008361	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62796792	62796792	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:62796792G>A	uc002jew.3	-	6	1159	c.248C>T	c.(247-249)TCC>TTC	p.S83F	PLEKHM1P_uc002jev.3_RNA|PLEKHM1P_uc010wqe.1_Missense_Mutation_p.S83F	NR_024386				RecName: Full=Putative pleckstrin homology domain-containing family M member 1P;												0						GTCCTGGGAGGAGGCGCGCAG	0.642			NA											6	26					0	0	0.001168	0	0
WIPI1	55062	broad.mit.edu	37	17	66440705	66440705	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:66440705G>A	uc010dey.2	-	4	450	c.359C>T	c.(358-360)TCC>TTC	p.S120F	WIPI1_uc002jhd.3_RNA|WIPI1_uc010wqo.1_Missense_Mutation_p.S38F|WIPI1_uc002jhe.3_RNA	NM_017983	NP_060453	Q5MNZ9	WIPI1_HUMAN	WD repeat domain, phosphoinositide interacting	120					macroautophagy|vesicle targeting, trans-Golgi to endosome	autophagic vacuole membrane|clathrin-coated vesicle|cytosol|endosome membrane|PAS complex|pre-autophagosomal structure membrane|trans-Golgi network	androgen receptor binding|estrogen receptor binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding				0						AATATAAATGGACTCTTCTAG	0.428			NA											7	68					0	0	0.00308	0	0
C17orf28	283987	broad.mit.edu	37	17	72954520	72954520	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:72954520C>T	uc002jmj.3	-	11	1443	c.1294G>A	c.(1294-1296)GAG>AAG	p.E432K	C17orf28_uc010wrs.1_Missense_Mutation_p.E231K	NM_030630	NP_085133	Q8IV36	CQ028_HUMAN	hypothetical protein LOC283987	432	Helical; (Potential).					integral to membrane|plasma membrane	protein binding				0	all_lung(278;0.151)|Lung NSC(278;0.185)					AAGTTCCGCTCCCCGCTCAGA	0.632			NA									OREG0024721	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	12					0	0	0.009096	0	0
NUP85	79902	broad.mit.edu	37	17	73229160	73229160	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:73229160A>G	uc002jng.1	+	16	1782	c.1522A>G	c.(1522-1524)AGG>GGG	p.R508G	NUP85_uc010dgd.1_Missense_Mutation_p.R463G|NUP85_uc010wrv.1_Missense_Mutation_p.R462G|NUP85_uc002jnh.1_Missense_Mutation_p.R111G	NM_024844	NP_079120	Q9BW27	NUP85_HUMAN	nucleoporin 85	508					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			ovary(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			CAGGTTCCTCAGGGATTACTG	0.587			NA											3	114					0	0	0.004672	0	0
RHBDF2	79651	broad.mit.edu	37	17	74473863	74473863	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:74473863C>T	uc002jrq.1	-	7	1057	c.764G>A	c.(763-765)CGC>CAC	p.R255H	RHBDF2_uc002jrp.1_Missense_Mutation_p.R226H|RHBDF2_uc002jrr.1_Missense_Mutation_p.R107H|RHBDF2_uc010wtf.1_Missense_Mutation_p.R226H|RHBDF2_uc002jrs.1_Missense_Mutation_p.R250H	NM_024599	NP_078875	Q6PJF5	RHDF2_HUMAN	rhomboid, veinlet-like 6 isoform 1	255	Cytoplasmic (Potential).				negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity				0						CAGCACCGAGCGCCCCTGTGC	0.667			NA											11	63					0	0	0.008291	0	0
NARF	26502	broad.mit.edu	37	17	80436675	80436675	+	Splice_Site	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:80436675G>T	uc002kfg.3	+	6	661	c.521_splice	c.e6-1	p.G174_splice	NARF_uc002kff.3_Splice_Site_p.G115_splice|NARF_uc010wvo.1_Splice_Site_p.G129_splice|NARF_uc010wvp.1_Splice_Site_p.G46_splice|NARF_uc010dit.2_Splice_Site_p.G174_splice|NARF_uc002kfj.3_Splice_Site_p.G126_splice|NARF_uc002kfi.3_Splice_Site|NARF_uc002kfh.3_Splice_Site_p.G174_splice|NARF_uc002kfk.2_Splice_Site	NM_012336	NP_036468	Q9UHQ1	NARF_HUMAN	nuclear prelamin A recognition factor isoform a							lamin filament	lamin binding			skin(1)	1	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			TCTCTCCCCAGGCTGGGTCCG	0.642			NA											7	32					0.00448238	0.00496458	0.004482	1	0
USP14	9097	broad.mit.edu	37	18	196747	196747	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr18:196747C>A	uc002kkf.1	+	7	790	c.574C>A	c.(574-576)CAA>AAA	p.Q192K	USP14_uc002kkg.1_Missense_Mutation_p.Q157K|USP14_uc010wyr.1_Missense_Mutation_p.Q181K	NM_005151	NP_005142	P54578	UBP14_HUMAN	ubiquitin specific protease 14 isoform a	192					regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)	2		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				GAAAGGTGAACAAGGACAGTA	0.368			NA											20	126					2.27731e-05	2.936e-05	0.001882	1	0
EMILIN2	84034	broad.mit.edu	37	18	2913094	2913094	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr18:2913094T>A	uc002kln.2	+	8	3013	c.2854T>A	c.(2854-2856)TAC>AAC	p.Y952N		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	952	C1q.				cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		TGATGGGCGCTACCTGATCAC	0.627			NA											5	47					0	0	0.001168	0	0
DLGAP1	9229	broad.mit.edu	37	18	3534268	3534268	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr18:3534268C>T	uc002kmf.2	-	7	2470	c.2403G>A	c.(2401-2403)CAG>CAA	p.Q801Q	DLGAP1_uc010wyz.1_Silent_p.Q801Q|DLGAP1_uc002kme.1_Silent_p.Q499Q|DLGAP1_uc010dkn.2_Silent_p.Q509Q|DLGAP1_uc010wyw.1_Silent_p.Q507Q|DLGAP1_uc010wyx.1_Silent_p.Q523Q|DLGAP1_uc010wyy.1_Silent_p.Q485Q|DLGAP1_uc002kmg.2_Silent_p.Q499Q	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	801					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				CTCGCTCTGCCTGGAGAAGCT	0.587			NA											10	26					0	0	0.000978	0	0
EPB41L3	23136	broad.mit.edu	37	18	5434024	5434024	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr18:5434024C>T	uc002kmt.1	-	7	788	c.702G>A	c.(700-702)CAG>CAA	p.Q234Q	EPB41L3_uc010wzh.1_Silent_p.Q234Q|EPB41L3_uc002kmu.1_Silent_p.Q234Q|EPB41L3_uc010dkq.1_Silent_p.Q125Q|EPB41L3_uc010dks.1_Silent_p.Q256Q|EPB41L3_uc002kmv.1_Silent_p.Q125Q	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	234	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						CGAGCTCTGACTGGACAGTGT	0.517			NA											7	70					0	0	0.001984	0	0
CIDEA	1149	broad.mit.edu	37	18	12262964	12262964	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr18:12262964G>T	uc002kqt.3	+	2	244	c.179G>T	c.(178-180)AGC>ATC	p.S60I	CIDEA_uc002kqu.3_Missense_Mutation_p.S94I|CIDEA_uc010dlc.2_RNA	NM_001279	NP_001270	O60543	CIDEA_HUMAN	cell death-inducing DFFA-like effector a isoform	60	CIDE-N.				DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change|lipid metabolic process|lipid storage|negative regulation of apoptosis|negative regulation of cytokine secretion|negative regulation of lipid catabolic process|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of sequestering of triglyceride|temperature homeostasis	mitochondrial envelope|nucleus	protein homodimerization activity			ovary(1)|central_nervous_system(1)	2						GAGCTCATCAGCAAGGTGCCC	0.642			NA											3	14					0.004672	0.00512029	0.004672	1	0
RNMT	8731	broad.mit.edu	37	18	13731883	13731883	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr18:13731883A>T	uc002ksk.1	+	2	434	c.367A>T	c.(367-369)ACT>TCT	p.T123S	RNMT_uc002ksl.1_Missense_Mutation_p.T123S|RNMT_uc002ksm.1_Missense_Mutation_p.T123S|RNMT_uc010dlk.2_Missense_Mutation_p.T123S|RNMT_uc010xae.1_Intron	NM_003799	NP_003790	O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	123					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding				0						TGGAGATGGCACTCAAAATAA	0.333	GBM(29;474 594 19092 36647 41529)		NA											12	73					0	0	0.001855	0	0
ZNF396	252884	broad.mit.edu	37	18	32954025	32954025	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr18:32954025G>A	uc010xcf.1	-	2	364	c.232C>T	c.(232-234)CAT>TAT	p.H78Y		NM_145756	NP_665699	Q96N95	ZN396_HUMAN	zinc finger protein 396	78	SCAN box.				viral reproduction	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGCCAGAGATGACAAAGTTCC	0.597			NA											6	38					0	0	0.001984	0	0
ELP2	55250	broad.mit.edu	37	18	33751061	33751061	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr18:33751061G>C	uc002kzk.1	+	21	2272	c.2262G>C	c.(2260-2262)TGG>TGC	p.W754C	ELP2_uc010xcg.1_Missense_Mutation_p.W819C|ELP2_uc002kzl.1_RNA|ELP2_uc002kzm.1_Missense_Mutation_p.W728C|ELP2_uc010xch.1_Missense_Mutation_p.W749C|ELP2_uc002kzn.1_Missense_Mutation_p.W684C|ELP2_uc002kzo.1_Missense_Mutation_p.W684C	NM_018255	NP_060725	Q6IA86	ELP2_HUMAN	elongator protein 2	754					regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4						TATATACCTGGAAAAAGACTG	0.368			NA											4	39					0	0	0.009096	0	0
PIK3C3	5289	broad.mit.edu	37	18	39570474	39570474	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr18:39570474G>T	uc002lap.2	+	6	728	c.670G>T	c.(670-672)GTC>TTC	p.V224F	PIK3C3_uc010xcl.1_Missense_Mutation_p.V161F	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	224					cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						ATTTCGATGTGTCAAGTGTGA	0.308	NSCLC(37;552 1060 2683 16430 37914)		NA								TSP Lung(28;0.18)			6	43					1.76689e-08	2.55257e-08	0.006214	1	0
SLC14A1	6563	broad.mit.edu	37	18	43310394	43310395	+	Missense_Mutation	DNP	TA	TA	CT			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	TA	TA	-	-	TA	TA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr18:43310394_43310395TA>CT	uc010xcn.1	+	4	428_429	c.109_110TA>CT	c.(109-111)TAT>CTT	p.Y37L	SLC14A1_uc010dnk.2_Missense_Mutation_p.Y93L|SLC14A1_uc002lbf.3_Missense_Mutation_p.Y37L|SLC14A1_uc002lbg.3_RNA|SLC14A1_uc010xco.1_Intron|SLC14A1_uc002lbh.3_Intron|SLC14A1_uc002lbi.3_Intron|SLC14A1_uc002lbj.3_Missense_Mutation_p.Y93L|SLC14A1_uc002lbk.3_Missense_Mutation_p.Y37L	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	37						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2						AGCTCTTGGCTATGTCACCGGT	0.485			NA											11	62					0	0	0.004672	0	0
TCEB3B	51224	broad.mit.edu	37	18	44561625	44561625	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr18:44561625C>T	uc002lcr.1	-	1	364	c.11G>A	c.(10-12)GGG>GAG	p.G4E	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	4					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CGTAGTGGACCCTGCCGCCAT	0.617			NA											4	29					0	0	0.009096	0	0
NEDD4L	23327	broad.mit.edu	37	18	56033381	56033381	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr18:56033381G>T	uc002lgy.2	+	21	2258	c.1984G>T	c.(1984-1986)GGT>TGT	p.G662C	NEDD4L_uc002lgz.2_Missense_Mutation_p.G598C|NEDD4L_uc002lgx.2_Missense_Mutation_p.G642C|NEDD4L_uc010xee.1_Missense_Mutation_p.G541C|NEDD4L_uc002lhc.2_Missense_Mutation_p.G654C|NEDD4L_uc002lhd.2_Missense_Mutation_p.G541C|NEDD4L_uc002lhb.2_Missense_Mutation_p.G521C|NEDD4L_uc002lhe.2_Missense_Mutation_p.G634C|NEDD4L_uc002lhf.2_Missense_Mutation_p.G521C|NEDD4L_uc002lhg.2_Missense_Mutation_p.G541C|NEDD4L_uc002lhh.2_Missense_Mutation_p.G437C|NEDD4L_uc010dpn.2_5'UTR	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally	662	HECT.				cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4						TGACTATGGGGGTGTGGCCAG	0.458			NA											4	29					0.00909568	0.00987956	0.009096	1	0
KIAA1468	57614	broad.mit.edu	37	18	59855222	59855222	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr18:59855222G>T	uc002lil.2	+	1	699	c.484G>T	c.(484-486)GGA>TGA	p.G162*	PIGN_uc002lii.3_5'Flank|PIGN_uc002lij.3_5'Flank|KIAA1468_uc002lik.1_Nonsense_Mutation_p.G162*|KIAA1468_uc010xel.1_Nonsense_Mutation_p.G162*	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	162							binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				TGGGGGCGCTGGAGGTCGGGA	0.642			NA									OREG0025032	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	8					5.9392e-07	8.17619e-07	0.001168	1	0
KIAA1468	57614	broad.mit.edu	37	18	59888679	59888679	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr18:59888679G>T	uc002lil.2	+	5	1022	c.807G>T	c.(805-807)AAG>AAT	p.K269N	KIAA1468_uc002lik.1_Missense_Mutation_p.K269N|KIAA1468_uc010xel.1_Missense_Mutation_p.K269N|KIAA1468_uc002lim.2_5'UTR	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	269	LisH.						binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				TTTTATTGAAGAATAACTATA	0.299			NA											8	61					0.000157383	0.000192065	0.00308	1	0
SERPINB8	5271	broad.mit.edu	37	18	61645624	61645624	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr18:61645624G>A	uc002ljv.2	+	2	251	c.82G>A	c.(82-84)GTA>ATA	p.V28I	SERPINB8_uc002ljs.1_Missense_Mutation_p.V28I|SERPINB8_uc002ljt.2_Missense_Mutation_p.V28I|SERPINB8_uc002lju.2_Missense_Mutation_p.V28I|SERPINB8_uc010xex.1_Intron	NM_198833	NP_942130	P50452	SPB8_HUMAN	serine (or cysteine) proteinase inhibitor, clade	28					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			skin(1)	1		Esophageal squamous(42;0.129)				CTCAAGAAACGTATTCTTCTC	0.488			NA											18	55					0	0	0.00499	0	0
CTDP1	9150	broad.mit.edu	37	18	77464788	77464788	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr18:77464788G>T	uc002lnh.1	+	5	790	c.643G>T	c.(643-645)GGC>TGC	p.G215C	CTDP1_uc002lni.1_Missense_Mutation_p.G215C|CTDP1_uc010drd.1_Missense_Mutation_p.G215C	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	215	FCP1 homology.				positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		CTTCCAGCTGGGCCGGGGTGA	0.607			NA											5	55					2.7689e-08	3.97655e-08	0.001984	1	0
ABCA7	10347	broad.mit.edu	37	19	1055931	1055931	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:1055931G>A	uc002lqw.3	+	31	4462	c.4231G>A	c.(4231-4233)GAG>AAG	p.E1411K	ABCA7_uc010dsb.1_Missense_Mutation_p.E1273K|ABCA7_uc002lqy.2_5'Flank|ABCA7_uc010dsc.2_5'Flank	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	1411	Extracellular (By similarity).				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGGTGAATGAGGTCAGGTG	0.632			NA											9	30					0	0	0.008291	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2410317	2410317	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:2410317C>T	uc010xgx.1	+	8	1077	c.1077C>T	c.(1075-1077)GCC>GCT	p.A359A	TMPRSS9_uc002lvv.1_Silent_p.A393A	NM_182973	NP_892018	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	359	Extracellular (Potential).|Peptidase S1 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACTGTGTGCCAGCTTGTACG	0.627			NA											8	44					0	0	0.00308	0	0
NFIC	4782	broad.mit.edu	37	19	3433537	3433537	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:3433537G>C	uc010xhi.1	+	4	718	c.656G>C	c.(655-657)AGC>ACC	p.S219T	NFIC_uc002lxo.2_Missense_Mutation_p.S210T|NFIC_uc010xhh.1_Missense_Mutation_p.S210T|NFIC_uc002lxp.2_Missense_Mutation_p.S219T|NFIC_uc010xhj.1_Missense_Mutation_p.S219T|NFIC_uc002lxq.1_Missense_Mutation_p.S171T	NM_205843	NP_995315	P08651	NFIC_HUMAN	nuclear factor I/C isoform 2	219					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		TTCCAGGAGAGCTTTGTCACC	0.622			NA											4	34					0	0	0.000602	0	0
EBI3	10148	broad.mit.edu	37	19	4231316	4231316	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:4231316T>A	uc002lzu.2	+	2	204	c.196T>A	c.(196-198)TAC>AAC	p.Y66N		NM_005755	NP_005746	Q14213	IL27B_HUMAN	Epstein-Barr virus induced 3 precursor	66	Fibronectin type-III 1.				humoral immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of interferon-gamma biosynthetic process|T-helper 1 type immune response	extracellular space|plasma membrane	cytokine activity|cytokine receptor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0336)|STAD - Stomach adenocarcinoma(1328;0.18)		CATTGCCACGTACAGGTCGGA	0.637			NA											3	15					0	0	0.009096	0	0
FBN3	84467	broad.mit.edu	37	19	8160275	8160275	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:8160275A>T	uc002mjf.2	-	45	5790	c.5769T>A	c.(5767-5769)GAT>GAA	p.D1923E		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1923	EGF-like 30; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						AGTTCTTCCCATCAGCTGTGA	0.517			NA											4	33					0	0	0.000602	0	0
MUC16	94025	broad.mit.edu	37	19	9064859	9064859	+	Silent	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:9064859A>T	uc002mkp.2	-	3	22791	c.22587T>A	c.(22585-22587)ACT>ACA	p.T7529T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7531	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAATTTTCCTAGTGTTAGATA	0.478			NA											12	55					0	0	0.001368	0	0
MUC16	94025	broad.mit.edu	37	19	9065531	9065531	+	Silent	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:9065531G>C	uc002mkp.2	-	3	22119	c.21915C>G	c.(21913-21915)ACC>ACG	p.T7305T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7307	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTTTTCTTGTGGTGGATATTT	0.463			NA											8	38					0	0	0.00308	0	0
MUC16	94025	broad.mit.edu	37	19	9088103	9088103	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:9088103T>C	uc002mkp.2	-	1	3916	c.3712A>G	c.(3712-3714)ACC>GCC	p.T1238A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1238	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGCTGAGGGTTGGAAGTCCC	0.507			NA											60	293					0	0	0.00361	0	0
CYP4F22	126410	broad.mit.edu	37	19	15648395	15648395	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:15648395C>A	uc002nbh.3	+	6	638	c.471C>A	c.(469-471)CGC>CGA	p.R157R		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	157						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2						GGCACCGTCGCCTGCTGACAC	0.547			NA											12	55					6.40141e-05	8.01272e-05	0.000978	1	0
MYO9B	4650	broad.mit.edu	37	19	17212808	17212808	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:17212808G>T	uc010eak.2	+	2	433	c.281G>T	c.(280-282)CGG>CTG	p.R94L	MYO9B_uc002nfi.2_Missense_Mutation_p.R94L|MYO9B_uc002nfj.1_Missense_Mutation_p.R94L	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	94	Ras-associating.|Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						TGGCCCCGGCGGGCACAGGAC	0.607			NA											3	20					0.004672	0.00512029	0.004672	1	0
UNC13A	23025	broad.mit.edu	37	19	17756920	17756920	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:17756920A>T	uc002nhd.2	-	18	2309	c.2309T>A	c.(2308-2310)GTG>GAG	p.V770E		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	682	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						GGCGCAGACCACTGGAAGACA	0.567			NA											3	18					0	0	0.009096	0	0
GDF15	9518	broad.mit.edu	37	19	18499157	18499157	+	Silent	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:18499157G>C	uc002niv.2	+	2	371	c.339G>C	c.(337-339)GGG>GGC	p.G113G		NM_004864	NP_004855	Q99988	GDF15_HUMAN	growth differentiation factor 15	113					cell-cell signaling|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)	1						TTCCCGAGGGGCTCCCCGAGG	0.701			NA									OREG0025363	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	21					0	0	0.004672	0	0
TMEM59L	25789	broad.mit.edu	37	19	18729267	18729267	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:18729267C>T	uc002njy.3	+	7	952	c.865C>T	c.(865-867)CTG>TTG	p.L289L		NM_012109	NP_036241	Q9UK28	TM59L_HUMAN	brain-specific membrane-anchored protein	289	Helical; (Potential).					Golgi membrane|integral to membrane|membrane fraction				ovary(2)|skin(2)	4						CTGCTCCACCCTGGTGACCGC	0.677			NA											3	12					0	0	0.004672	0	0
ZNF90	7643	broad.mit.edu	37	19	20215049	20215049	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:20215049G>C	uc002nor.2	+	2	144	c.5G>C	c.(4-6)GGA>GCA	p.G2A	ZNF90_uc002nos.1_RNA|ZNF90_uc002not.1_Intron	NM_007138	NP_009069	Q03938	ZNF90_HUMAN	zinc finger protein 90	2						Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GTTTTTCAGGGACCATTGGAA	0.403			NA											7	72					0	0	0.001984	0	0
ZNF676	163223	broad.mit.edu	37	19	22363427	22363427	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:22363427G>T	uc002nqs.1	-	3	1410	c.1092C>A	c.(1090-1092)CCC>CCA	p.P364P		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	364					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CACATTTGTAGGGTTTCTCTC	0.388			NA											9	53					3.09899e-07	4.29859e-07	0.004482	1	0
ZNF99	7652	broad.mit.edu	37	19	22940689	22940689	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:22940689C>G	uc010xrh.1	-	5	1749	c.1749G>C	c.(1747-1749)GAG>GAC	p.E583D		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TGTAGGGTTTCTCTTCAGTAT	0.363			NA											6	24					0	0	0.001168	0	0
ZNF536	9745	broad.mit.edu	37	19	30935819	30935819	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:30935819C>A	uc002nsu.1	+	2	1488	c.1350C>A	c.(1348-1350)AGC>AGA	p.S450R	ZNF536_uc010edd.1_Missense_Mutation_p.S450R	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	450					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCGAGCCCAGCCAGCTCTATG	0.657			NA											7	19					0.000157383	0.000192065	0.00308	1	0
ZNF536	9745	broad.mit.edu	37	19	30936301	30936301	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:30936301G>T	uc002nsu.1	+	2	1970	c.1832G>T	c.(1831-1833)GGG>GTG	p.G611V	ZNF536_uc010edd.1_Missense_Mutation_p.G611V	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	611					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TTGTCACACGGGCTGAACCAG	0.557			NA											12	94					1.61879e-10	2.53391e-10	0.001368	1	0
TSHZ3	57616	broad.mit.edu	37	19	31767930	31767930	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:31767930G>T	uc002nsy.3	-	2	2834	c.2769C>A	c.(2767-2769)ATC>ATA	p.I923I		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	923	Homeobox; atypical.				negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					GGTCTGACATGATGTACTTCC	0.607			NA											3	27					0.00909568	0.00987956	0.009096	1	0
TSHZ3	57616	broad.mit.edu	37	19	31768285	31768285	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:31768285G>T	uc002nsy.3	-	2	2479	c.2414C>A	c.(2413-2415)TCA>TAA	p.S805*		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	805					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CAGAAGCACTGAACCCAAGGA	0.542			NA											9	34					1.12685e-05	1.47621e-05	0.004482	1	0
USF2	7392	broad.mit.edu	37	19	35769860	35769860	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:35769860G>T	uc002nyq.1	+	9	943	c.834G>T	c.(832-834)GGG>GGT	p.G278G	USF2_uc010xss.1_Silent_p.G278G|USF2_uc002nyr.1_Silent_p.G211G|USF2_uc002nys.1_Silent_p.G80G|USF2_uc002nyt.1_Silent_p.G147G|USF2_uc002nyu.1_Silent_p.G80G|USF2_uc002nyv.1_Intron	NM_003367	NP_003358	Q15853	USF2_HUMAN	upstream stimulatory factor 2 isoform 1	278	Helix-loop-helix motif.				lipid homeostasis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by glucose	nucleus	bHLH transcription factor binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity				0	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)		Epithelial(14;7.4e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.47e-19)|all cancers(14;4.17e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GTAAAGGAGGGATCCTGTCCA	0.652	NSCLC(103;173 2832 8890)		NA											12	36					2.80697e-09	4.19611e-09	0.000978	1	0
FFAR3	2865	broad.mit.edu	37	19	35850521	35850521	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:35850521G>T	uc002nzd.2	+	2	804	c.729G>T	c.(727-729)GTG>GTT	p.V243V	FFAR3_uc010xsu.1_Intron	NM_005304	NP_005295	O14843	FFAR3_HUMAN	free fatty acid receptor 3	243	Helical; Name=6; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding				0	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			CCTACAACGTGTCCCATGTCG	0.627	Esophageal Squamous(185;1742 2042 21963 24215 27871)		NA											13	178					9.05144e-12	1.47692e-11	0.001855	1	0
TMEM149	79713	broad.mit.edu	37	19	36230816	36230816	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:36230816G>A	uc002obc.2	-	4	617	c.516C>T	c.(514-516)ACC>ACT	p.T172T	TMEM149_uc002obb.2_Intron|TMEM149_uc002obd.3_Silent_p.T172T|TMEM149_uc010xsy.1_RNA|TMEM149_uc010eej.2_Silent_p.T252T	NM_024660	NP_078936	Q9H665	IGFR1_HUMAN	transmembrane protein 149 precursor	172	Helical; (Potential).					integral to membrane|plasma membrane	protein binding|receptor activity				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCACCGCCAAGGTCAGGAGCA	0.602			NA											16	59					0	0	0.003163	0	0
ZNF585B	92285	broad.mit.edu	37	19	37676140	37676140	+	Missense_Mutation	SNP	T	T	A	rs149106602		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:37676140T>A	uc002ofq.2	-	5	2553	c.2299A>T	c.(2299-2301)AGC>TGC	p.S767C	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Missense_Mutation_p.S581C	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	767	C2H2-type 21.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CAAGCGTGGCTGCTCTGATGA	0.448	Melanoma(93;882 1454 18863 28917 48427)		NA											17	80					0	0	0.006122	0	0
CYP2B7P1	1556	broad.mit.edu	37	19	41447305	41447306	+	Missense_Mutation	DNP	GA	GA	TG			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:41447305_41447306GA>TG	uc010ehh.1	+	5	758_759	c.750_751GA>TG	c.(748-753)GAGAAG>GATGAG	p.250_251EK>DE	CYP2A7_uc002opo.2_Intron|CYP2B7P1_uc002opq.2_RNA					SubName: Full=Cytochrome P450, family 2, subfamily B, polypeptide 6;											ovary(1)|skin(1)	2						ACAGTGTGGAGAAGCACCGTGA	0.465			NA											10	88					0	0	0.004672	0	0
CYP2F1	1572	broad.mit.edu	37	19	41622111	41622111	+	Silent	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:41622111A>T	uc002opu.1	+	2	74	c.18A>T	c.(16-18)ACA>ACT	p.T6T	CYP2F1_uc010xvw.1_Intron|CYP2F1_uc010xvv.1_Silent_p.T6T|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F,	6					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0						GCATAAGCACAGCCATCTTAC	0.577			NA											18	85					0	0	0.006122	0	0
PSG5	5673	broad.mit.edu	37	19	43679578	43679578	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:43679578G>A	uc002ovu.2	-	4	884	c.753C>T	c.(751-753)TAC>TAT	p.Y251Y	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Silent_p.Y126Y|PSG5_uc002ovx.2_Silent_p.Y251Y|PSG5_uc002ovv.2_Silent_p.Y344Y|PSG5_uc002ovw.2_Intron	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	251	Ig-like C2-type 2.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				CTCCTGAACGGTAATAGGTGA	0.478			NA											22	170					0	0	0.010504	0	0
SIX5	147912	broad.mit.edu	37	19	46270388	46270388	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:46270388C>G	uc002pdb.2	-	2	1224	c.829G>C	c.(829-831)GAG>CAG	p.E277Q	SIX5_uc002pdc.2_Intron	NM_175875	NP_787071	Q8N196	SIX5_HUMAN	SIX homeobox 5	277						cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00783)|GBM - Glioblastoma multiforme(486;0.0802)|Epithelial(262;0.235)		GACTCGTCCTCAGTCGTGGGA	0.677			NA											3	19					0	0	0.004672	0	0
TPRX1	284355	broad.mit.edu	37	19	48305217	48305217	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:48305217G>A	uc002php.1	-	2	1122	c.1051C>T	c.(1051-1053)CCT>TCT	p.P351S		NM_198479	NP_940881	Q8N7U7	TPRX1_HUMAN	tetra-peptide repeat homeobox	351						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;3.02e-09)|all_epithelial(76;7e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000241)|all cancers(93;0.00036)|Epithelial(262;0.0127)|GBM - Glioblastoma multiforme(486;0.048)		GTGAAGTGAGGGAATAACTGG	0.433	Esophageal Squamous(123;175 2281 3051 32395)		NA											15	52					0	0	0.003163	0	0
NUP62	23636	broad.mit.edu	37	19	50411625	50411625	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:50411625C>A	uc002pqx.2	-	2	1544	c.1440G>T	c.(1438-1440)GCG>GCT	p.A480A	IL4I1_uc002pqv.1_Intron|IL4I1_uc010eno.1_Intron|IL4I1_uc002pqw.1_Intron|IL4I1_uc002pqu.1_Intron|NUP62_uc002pqy.2_Silent_p.A480A|NUP62_uc002pqz.2_Silent_p.A480A|NUP62_uc002pra.2_Silent_p.A480A|NUP62_uc002prb.2_Silent_p.A480A|NUP62_uc002prc.2_Silent_p.A404A	NM_153719	NP_714941	P37198	NUP62_HUMAN	nucleoporin 62kDa	480					carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding				0		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		AGTCCATGTGCGCATTGAGGA	0.627			NA											15	110					3.41278e-10	5.2743e-10	0.00499	1	0
KLK13	26085	broad.mit.edu	37	19	51560016	51560016	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:51560016G>A	uc002pvn.2	-	5	705	c.662C>T	c.(661-663)CCC>CTC	p.P221L	KLK13_uc002pvl.2_RNA|KLK13_uc002pvm.2_RNA|KLK13_uc002pvo.2_RNA|KLK13_uc002pvp.2_RNA|KLK13_uc010eon.2_Missense_Mutation_p.P148L|KLK13_uc002pvq.2_RNA|KLK13_uc010eoo.2_Missense_Mutation_p.P69L	NM_015596	NP_056411	Q9UKR3	KLK13_HUMAN	kallikrein 13 precursor	221	Peptidase S1.				proteolysis		protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00432)		ACAGACCAGGGGGCCCCCAGA	0.582			NA											8	42					0	0	0.00308	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52132731	52132731	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:52132731G>T	uc002pxe.2	-	3	719	c.580C>A	c.(580-582)CGC>AGC	p.R194S		NM_003830	NP_003821	O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5 precursor	194	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion	integral to membrane	sugar binding			skin(2)|breast(1)|central_nervous_system(1)	4		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		TCCGAGGAGCGGGTGGTCTCG	0.637			NA											5	25					0.000602214	0.000706611	0.000602	1	0
ZNF432	9668	broad.mit.edu	37	19	52538203	52538203	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:52538203G>T	uc002pyk.2	-	5	1047	c.729C>A	c.(727-729)TCC>TCA	p.S243S		NM_014650	NP_055465	O94892	ZN432_HUMAN	zinc finger protein 432	243	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|pancreas(1)	3		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.0054)|OV - Ovarian serous cystadenocarcinoma(262;0.0182)		TGGACTTTCTGGAGAACACTT	0.388			NA											24	135					4.59853e-10	7.03248e-10	0.005443	1	0
ZNF841	284371	broad.mit.edu	37	19	52569171	52569171	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:52569171C>G	uc002pyl.1	-	5	2168	c.1616G>C	c.(1615-1617)TGT>TCT	p.C539S	ZNF841_uc010ydh.1_Missense_Mutation_p.C655S|ZNF841_uc010epk.1_Intron	NM_001136499	NP_001129971	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	539	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACAATCATTACATTTATAAGG	0.423			NA											14	87					0	0	0.001855	0	0
ZNF836	162962	broad.mit.edu	37	19	52663757	52663757	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:52663757C>T	uc010ydi.1	-	4	477	c.103G>A	c.(103-105)GAT>AAT	p.D35N	ZNF836_uc010ydj.1_Missense_Mutation_p.D35N	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	35	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AACATCACATCCCAGTACAAA	0.433			NA											16	84					0	0	0.004007	0	0
ZNF534	147658	broad.mit.edu	37	19	52941164	52941164	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:52941164A>C	uc002pzk.2	+	4	551	c.490A>C	c.(490-492)AGT>CGT	p.S164R	ZNF534_uc002pzj.1_Intron|ZNF534_uc010epo.1_Intron|ZNF534_uc002pzl.2_Missense_Mutation_p.S151R	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	164					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGTTCAAATAAGTTTTTTCAG	0.323			NA											9	42					0	0	0.004482	0	0
ZNF813	126017	broad.mit.edu	37	19	53995126	53995126	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:53995126G>C	uc002qbu.2	+	4	1768	c.1640G>C	c.(1639-1641)GGA>GCA	p.G547A	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	547					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		CTTCATACTGGAGATAAACCT	0.378			NA											9	20					0	0	0.004482	0	0
U2AF2	11338	broad.mit.edu	37	19	56173908	56173908	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:56173908G>T	uc002qlu.2	+	6	1582	c.527G>T	c.(526-528)GGG>GTG	p.G176V	U2AF2_uc002qlt.2_Missense_Mutation_p.G176V	NM_007279	NP_009210	P26368	U2AF2_HUMAN	U2 (RNU2) small nuclear RNA auxiliary factor 2	176	RRM 1.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			ovary(1)	1		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		ATGCGCCTGGGGGGGCTGACC	0.458			NA											5	53					0.00116845	0.00134087	0.001168	1	0
NLRP13	126204	broad.mit.edu	37	19	56424218	56424218	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:56424218C>G	uc010ygg.1	-	5	990	c.965G>C	c.(964-966)CGC>CCC	p.R322P		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	322	NACHT.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GCTCTCAGAGCGTGACTCAGA	0.463			NA											13	53					0	0	0.001368	0	0
ZNF470	388566	broad.mit.edu	37	19	57089368	57089368	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr19:57089368T>A	uc002qnl.3	+	6	2247	c.1571T>A	c.(1570-1572)CTC>CAC	p.L524H	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	524	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		AATGCACACCTCGCGCAACAT	0.463			NA											11	40					0	0	0.008291	0	0
TMEM18	129787	broad.mit.edu	37	2	675509	675509	+	Splice_Site	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:675509C>A	uc002qwl.2	-	2	272	c.178_splice	c.e2+1	p.V60_splice	TMEM18_uc002qwk.2_Splice_Site|uc002qwm.1_5'Flank	NM_152834	NP_690047	Q96B42	TMM18_HUMAN	transmembrane protein 18						cell migration	integral to membrane|nuclear membrane				ovary(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;5.27e-05)|all_epithelial(98;2.11e-06)|Ovarian(717;0.0253)		all cancers(51;1.95e-21)|Epithelial(75;9.47e-21)|OV - Ovarian serous cystadenocarcinoma(76;8.15e-18)|GBM - Glioblastoma multiforme(21;0.0285)		GTTTTACTCACCTAGACACAG	0.468			NA											12	59					2.61681e-11	4.18576e-11	0.00245	1	0
PXDN	7837	broad.mit.edu	37	2	1653320	1653320	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:1653320G>T	uc002qxa.2	-	17	2296	c.2232C>A	c.(2230-2232)CAC>CAA	p.H744Q		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	744					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		AGGTGCCGTCGTGCGTCCGGT	0.612			NA											14	93					1.5739e-10	2.46892e-10	0.004007	1	0
GRHL1	29841	broad.mit.edu	37	2	10136041	10136041	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:10136041G>T	uc002raa.2	+	13	1705	c.1534G>T	c.(1534-1536)GAT>TAT	p.D512Y	GRHL1_uc002rab.2_RNA|GRHL1_uc002rad.2_Missense_Mutation_p.D323Y|GRHL1_uc010yjb.1_Missense_Mutation_p.D361Y	NM_198182	NP_937825	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1	512					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		CGGCACAGAAGATGACTTTGC	0.453			NA											25	185					1.1804e-14	2.01135e-14	0.003954	1	0
NCOA1	8648	broad.mit.edu	37	2	24929509	24929509	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:24929509C>T	uc002rfk.2	+	11	1428	c.1170C>T	c.(1168-1170)GTC>GTT	p.V390V	NCOA1_uc010eye.2_Silent_p.V390V|NCOA1_uc002rfi.2_Silent_p.V239V|NCOA1_uc002rfj.2_Silent_p.V390V|NCOA1_uc002rfl.2_Silent_p.V390V	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	390	Interaction with STAT3.|Ser-rich.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATCCCTCGGTCAATCCTAGTA	0.473			NA	T	PAX3	alveolar rhadomyosarcoma								4	38					0	0	0.001168	0	0
C2orf53	339779	broad.mit.edu	37	2	27360020	27360020	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:27360020G>T	uc002rjb.2	-	3	1758	c.1178C>A	c.(1177-1179)CCT>CAT	p.P393H	PREB_uc002rix.1_5'Flank|PREB_uc002riy.1_5'Flank|PREB_uc002riz.1_5'Flank|PREB_uc002rja.1_5'Flank	NM_178553	NP_848648	Q53SZ7	CB053_HUMAN	hypothetical protein LOC339779	393											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCAGGGCAAGGCCTGGGCTT	0.582			NA											12	66					4.3838e-07	6.06924e-07	0.001855	1	0
DNAJC5G	285126	broad.mit.edu	37	2	27501140	27501140	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:27501140C>T	uc002rjl.1	+	5	878	c.460C>T	c.(460-462)CCT>TCT	p.P154S	SLC30A3_uc010ylh.1_5'Flank|DNAJC5G_uc010yli.1_Silent_p.H66H|DNAJC5G_uc002rjm.1_Missense_Mutation_p.P154S	NM_173650	NP_775921	Q8N7S2	DNJ5G_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	154					protein folding	membrane	heat shock protein binding|unfolded protein binding			skin(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TAAACCACCACCTGAGCAGGA	0.403			NA											5	23					0	0	0.000602	0	0
XDH	7498	broad.mit.edu	37	2	31573033	31573033	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:31573033C>T	uc002rnv.1	-	25	2767	c.2688G>A	c.(2686-2688)CGG>CGA	p.R896R		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	896					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GCCCAGTGCCCCGGATGTTGG	0.532	Colon(66;682 1445 30109 40147)		NA											11	84					0	0	0.000978	0	0
FSHR	2492	broad.mit.edu	37	2	49190968	49190968	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:49190968G>T	uc002rww.2	-	10	1066	c.992C>A	c.(991-993)ACT>AAT	p.T331N	FSHR_uc002rwx.2_Missense_Mutation_p.T269N|FSHR_uc010fbn.2_Missense_Mutation_p.T305N	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	331	Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GTCAAACTCAGTGTACGTCAT	0.463			NA							Gonadal_Dysgenesis_46_XX				11	142					5.16669e-11	8.19273e-11	0.000978	1	0
NRXN1	9378	broad.mit.edu	37	2	50149280	50149280	+	Silent	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:50149280G>C	uc010fbp.2	-	6	1938	c.1131C>G	c.(1129-1131)GCC>GCG	p.A377A	NRXN1_uc002rxb.3_Silent_p.A1111A|NRXN1_uc010fbq.2_Silent_p.A1482A|NRXN1_uc002rxe.3_Silent_p.A1412A|NRXN1_uc010yon.1_Silent_p.A77A|NRXN1_uc002rxa.3_Silent_p.A74A	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	377	Poly-Ala.|Helical; (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GGATGCACAGGGCGGCAGCGG	0.562			NA											6	45					0	0	0.001984	0	0
MPHOSPH10	10199	broad.mit.edu	37	2	71361141	71361141	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:71361141G>T	uc002sht.1	+	3	1184	c.832G>T	c.(832-834)GAC>TAC	p.D278Y	MPHOSPH10_uc010feb.1_Missense_Mutation_p.D278Y	NM_005791	NP_005782	O00566	MPP10_HUMAN	M-phase phosphoprotein 10	278					RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			skin(2)|ovary(1)	3						AAGTGATGAAGACATAACAAA	0.303			NA											7	38					8.12818e-05	0.000100707	0.001984	1	0
IL1RL2	8808	broad.mit.edu	37	2	102818106	102818106	+	Missense_Mutation	SNP	G	G	T	rs142080534		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:102818106G>T	uc002tbs.2	+	5	706	c.580G>T	c.(580-582)GCG>TCG	p.A194S	IL1RL2_uc002tbt.2_Missense_Mutation_p.A77S	NM_003854	NP_003845	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2 precursor	194	Extracellular (Potential).|Ig-like C2-type 2.				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			ovary(2)	2						AGGGAACTACGCGTGTCAAGC	0.473			NA											8	51					5.18039e-06	6.91034e-06	0.00308	1	0
SLC9A4	389015	broad.mit.edu	37	2	103120017	103120017	+	Silent	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:103120017G>C	uc002tbz.3	+	3	1288	c.831G>C	c.(829-831)GGG>GGC	p.G277G		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	277	Helical; Name=H/M6; (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						GGCTTGGAGGGGTATTGTTTG	0.398			NA											6	64					0	0	0.001168	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459724	107459724	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:107459724C>A	uc002tdq.2	-	2	829	c.710G>T	c.(709-711)CGC>CTC	p.R237L	ST6GAL2_uc002tdr.2_Missense_Mutation_p.R237L|ST6GAL2_uc002tds.3_Missense_Mutation_p.R237L	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	237	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						CCCGCGGAAGCGCACCCCGTG	0.687			NA											3	6					0.004672	0.00512029	0.004672	1	0
PTPN4	5775	broad.mit.edu	37	2	120714508	120714508	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:120714508C>T	uc002tmf.1	+	21	2840	c.2069C>T	c.(2068-2070)CCT>CTT	p.P690L	PTPN4_uc010flj.1_Missense_Mutation_p.P403L|PTPN4_uc010yyr.1_Missense_Mutation_p.P323L	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	690	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	GATATTTCGCCTTGTAAGTAT	0.289			NA											15	105					0	0	0.00245	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125204494	125204494	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:125204494G>T	uc002tno.2	+	6	1262	c.898G>T	c.(898-900)GCC>TCC	p.A300S	CNTNAP5_uc010flu.2_Missense_Mutation_p.A300S	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	300	Laminin G-like 1.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CGAGACGGATGCCTTAGACAT	0.557			NA											8	40					5.18039e-06	6.91034e-06	0.00308	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125530543	125530543	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:125530543A>T	uc002tno.2	+	17	3062	c.2698A>T	c.(2698-2700)ACG>TCG	p.T900S	CNTNAP5_uc010flu.2_Missense_Mutation_p.T901S	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	900	Laminin G-like 3.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CACCAGGGAGACGTCGGAGGA	0.527			NA											6	113					0	0	0.001168	0	0
NCKAP5	344148	broad.mit.edu	37	2	133541158	133541158	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:133541158G>T	uc002ttp.2	-	14	3600	c.3226C>A	c.(3226-3228)CTG>ATG	p.L1076M	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1076							protein binding				0						GTCATTTCCAGTGGCTCATGG	0.512			NA											21	199					1.96895e-08	2.83886e-08	0.00278	1	0
THSD7B	80731	broad.mit.edu	37	2	137928454	137928454	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:137928454G>A	uc002tva.1	+	6	1576	c.1576G>A	c.(1576-1578)GGA>AGA	p.G526R	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Missense_Mutation_p.G416R	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CCCTGATCATGGAAAATGTGG	0.522			NA											10	39					0	0	0.006214	0	0
LRP1B	53353	broad.mit.edu	37	2	141083415	141083415	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:141083415A>G	uc002tvj.1	-	80	13228	c.12256T>C	c.(12256-12258)TAT>CAT	p.Y4086H		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4086	Extracellular (Potential).|LDL-receptor class B 36.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCAGCCCAATATATGCGTTCA	0.378	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			7	42					0	0	0.001984	0	0
ZEB2	9839	broad.mit.edu	37	2	145157460	145157460	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:145157460C>A	uc002tvu.2	-	8	1774	c.1294G>T	c.(1294-1296)GCT>TCT	p.A432S	ZEB2_uc002tvv.2_Missense_Mutation_p.A426S|ZEB2_uc010zbm.1_Missense_Mutation_p.A403S|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Missense_Mutation_p.A461S	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	432						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		GGACTCTGAGCAGATGGATGA	0.458	Melanoma(33;1235 1264 5755 16332)		NA											13	58					7.03913e-09	1.03118e-08	0.001368	1	0
RIF1	55183	broad.mit.edu	37	2	152301885	152301885	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:152301885C>A	uc002txm.2	+	19	2150	c.2020C>A	c.(2020-2022)CAT>AAT	p.H674N	RIF1_uc002txl.2_Missense_Mutation_p.H674N|RIF1_uc010fnv.1_Missense_Mutation_p.H638N|RIF1_uc002txn.2_Missense_Mutation_p.H674N|RIF1_uc002txo.2_Missense_Mutation_p.H674N	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	674					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TGCCTTAGAACATAATTTTAG	0.318			NA											9	87					2.17888e-05	2.81406e-05	0.006214	1	0
GALNT13	114805	broad.mit.edu	37	2	155099310	155099310	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:155099310T>G	uc002tyr.3	+	6	1145	c.578T>G	c.(577-579)CTT>CGT	p.L193R	GALNT13_uc002tyt.3_Missense_Mutation_p.L193R|GALNT13_uc010foc.1_Missense_Mutation_p.L12R	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	193	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CGTGCCCGTCTTCGAGGAGCA	0.423			NA											5	46					0	0	0.000602	0	0
GALNT13	114805	broad.mit.edu	37	2	155099313	155099313	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:155099313G>A	uc002tyr.3	+	6	1148	c.581G>A	c.(580-582)CGA>CAA	p.R194Q	GALNT13_uc002tyt.3_Missense_Mutation_p.R194Q|GALNT13_uc010foc.1_Missense_Mutation_p.R13Q	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	194	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						GCCCGTCTTCGAGGAGCAGCT	0.423			NA											5	43					0	0	0.000602	0	0
GALNT13	114805	broad.mit.edu	37	2	155158101	155158101	+	Silent	SNP	A	A	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:155158101A>C	uc002tyr.3	+	9	1722	c.1155A>C	c.(1153-1155)CCA>CCC	p.P385P	GALNT13_uc002tyt.3_Silent_p.P385P|GALNT13_uc010foc.1_Silent_p.P204P|GALNT13_uc010fod.2_Silent_p.P138P	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	385	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TCATATCCCCAGGTACACAAT	0.343			NA											9	109					0	0	0.008291	0	0
KCNJ3	3760	broad.mit.edu	37	2	155555778	155555778	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:155555778T>A	uc002tyv.1	+	1	686	c.491T>A	c.(490-492)TTC>TAC	p.F164Y	KCNJ3_uc010zce.1_Missense_Mutation_p.F164Y	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	164	Helical; Name=M2; (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	CTCTTCCTCTTCCAGTCCATC	0.577			NA											5	47					0	0	0.001168	0	0
SLC4A10	57282	broad.mit.edu	37	2	162751275	162751275	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:162751275C>T	uc002ubx.3	+	11	1465	c.1281C>T	c.(1279-1281)CTC>CTT	p.L427L	SLC4A10_uc010fpa.1_Silent_p.L439L|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Silent_p.L397L|SLC4A10_uc010zcs.1_Silent_p.L408L	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	427	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						TTACTGTTCTCCCTCCTGGAG	0.363			NA											11	68					0	0	0.001855	0	0
GRB14	2888	broad.mit.edu	37	2	165365354	165365354	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:165365354C>A	uc002ucl.2	-	7	1366	c.825G>T	c.(823-825)CGG>CGT	p.R275R	GRB14_uc010zcv.1_Silent_p.R188R|GRB14_uc002ucm.2_RNA	NM_004490	NP_004481	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	275	PH.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			ovary(5)|upper_aerodigestive_tract(1)|lung(1)	7						ACTGCAAATGCCGCGGTTCCT	0.323			NA											7	75					0.00198382	0.00223792	0.001984	1	0
SCN3A	6328	broad.mit.edu	37	2	165987815	165987815	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:165987815C>T	uc002ucx.2	-	16	2996	c.2504G>A	c.(2503-2505)AGT>AAT	p.S835N	SCN3A_uc002ucy.2_Missense_Mutation_p.S786N|SCN3A_uc002ucz.2_Missense_Mutation_p.S786N|SCN3A_uc002uda.1_Missense_Mutation_p.S655N|SCN3A_uc002udb.1_Missense_Mutation_p.S655N	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	835	Helical; Name=S3 of repeat II; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CTCCATTAAACTGAGGCTGAC	0.393			NA											11	97					0	0	0.008291	0	0
CSRNP3	80034	broad.mit.edu	37	2	166451702	166451702	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:166451702T>C	uc002udf.2	+	4	503	c.127T>C	c.(127-129)TCC>CCC	p.S43P	CSRNP3_uc002udg.2_Missense_Mutation_p.S43P	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	43	Ser-rich.				apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						TGTCAATCCATCCACTTCTAG	0.428			NA											13	82					0	0	0.003163	0	0
ABCB11	8647	broad.mit.edu	37	2	169780148	169780148	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:169780148C>G	uc002ueo.1	-	28	4076	c.3950G>C	c.(3949-3951)GGA>GCA	p.G1317A	ABCB11_uc010zda.1_Missense_Mutation_p.G735A|ABCB11_uc010zdb.1_Missense_Mutation_p.G793A	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	1317	Cytoplasmic (Potential).				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	GATGGGGGATCCAGTGGTGAC	0.473			NA											5	34					0	0	0.000602	0	0
LRP2	4036	broad.mit.edu	37	2	170097559	170097559	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:170097559C>A	uc002ues.2	-	25	4197	c.3984G>T	c.(3982-3984)CTG>CTT	p.L1328L	LRP2_uc010zdf.1_Silent_p.L1191L	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1328	LDL-receptor class A 15.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACACTACACTCAGATTCACAC	0.493			NA											8	61					0.000157383	0.000192065	0.00308	1	0
OSBPL6	114880	broad.mit.edu	37	2	179255873	179255873	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:179255873G>A	uc002ulx.2	+	22	2753	c.2375G>A	c.(2374-2376)CGG>CAG	p.R792Q	OSBPL6_uc002uly.2_Missense_Mutation_p.R817Q|OSBPL6_uc010zfe.1_Missense_Mutation_p.R761Q|OSBPL6_uc002ulz.2_Missense_Mutation_p.R756Q|OSBPL6_uc002uma.2_Missense_Mutation_p.R796Q	NM_032523	NP_115912	Q9BZF3	OSBL6_HUMAN	oxysterol-binding protein-like protein 6 isoform	792					lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			GCGGTGTACCGGCTGTTTGGA	0.507			NA											21	85					0	0	0.001882	0	0
TTN	7273	broad.mit.edu	37	2	179395788	179395788	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:179395788G>T	uc010zfg.1	-	307	98074	c.97850C>A	c.(97849-97851)ACC>AAC	p.T32617N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.T26312N|TTN_uc010zfi.1_Missense_Mutation_p.T26245N|TTN_uc010zfj.1_Missense_Mutation_p.T26120N|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33544							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATCTCAAAGGTTGATTTGTA	0.493			NA											30	240					3.1745e-13	5.29808e-13	0.008361	1	0
TTN	7273	broad.mit.edu	37	2	179424097	179424097	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:179424097C>A	uc010zfg.1	-	275	79282	c.79058G>T	c.(79057-79059)GGA>GTA	p.G26353V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G20048V|TTN_uc010zfi.1_Missense_Mutation_p.G19981V|TTN_uc010zfj.1_Missense_Mutation_p.G19856V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27280							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCATTTTCTCCAGAGACTCT	0.378			NA											11	186					1.5842e-08	2.29772e-08	0.001855	1	0
TTN	7273	broad.mit.edu	37	2	179427802	179427802	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:179427802A>G	uc010zfg.1	-	275	75577	c.75353T>C	c.(75352-75354)GTT>GCT	p.V25118A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V18813A|TTN_uc010zfi.1_Missense_Mutation_p.V18746A|TTN_uc010zfj.1_Missense_Mutation_p.V18621A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26045							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCACGCAGAACGACCACCTT	0.488			NA											20	173					0	0	0.001882	0	0
TTN	7273	broad.mit.edu	37	2	179640673	179640673	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:179640673G>C	uc010zfg.1	-	28	6142	c.5918C>G	c.(5917-5919)ACC>AGC	p.T1973S	TTN_uc010zfh.1_Missense_Mutation_p.T1927S|TTN_uc010zfi.1_Missense_Mutation_p.T1927S|TTN_uc010zfj.1_Missense_Mutation_p.T1927S|TTN_uc002unb.2_Missense_Mutation_p.T1973S|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1973							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACTTCTTTGGTTTCAGTGGT	0.443			NA											20	210					0	0	0.002299	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187698752	187698752	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:187698752G>C	uc002upu.1	-	6	789	c.749C>G	c.(748-750)ACC>AGC	p.T250S		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	250	ZZ-type.				apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			TATGCATTCGGTACACCTAAA	0.368			NA											4	32					0	0	0.009096	0	0
TMEFF2	23671	broad.mit.edu	37	2	192863879	192863879	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:192863879C>A	uc002utc.2	-	6	986	c.592G>T	c.(592-594)GAT>TAT	p.D198Y		NM_016192	NP_057276	Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two	198	Kazal-like 2.|Extracellular (Potential).					extracellular region|integral to membrane				lung(2)|pancreas(1)|breast(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			GATTTCCCATCAGAAGCGCAG	0.368	Pancreas(50;1277 1381 28487 47072)		NA											5	115					0.000602214	0.000706611	0.000602	1	0
SGOL2	151246	broad.mit.edu	37	2	201436413	201436413	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:201436413C>T	uc002uvw.2	+	7	1457	c.1344C>T	c.(1342-1344)CCC>CCT	p.P448P	SGOL2_uc010zhd.1_Silent_p.P448P|SGOL2_uc010zhe.1_Silent_p.P448P	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	448					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						CAGAAGATCCCGGTTTTATTT	0.403			NA											15	141					0	0	0.003163	0	0
MDH1B	130752	broad.mit.edu	37	2	207619756	207619756	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:207619756C>A	uc002vbs.2	-	5	942	c.887G>T	c.(886-888)AGA>ATA	p.R296I	MDH1B_uc010ziw.1_Intron|MDH1B_uc010fui.2_Missense_Mutation_p.R296I|MDH1B_uc010fuj.2_Missense_Mutation_p.R198I|MDH1B_uc002vbt.2_Intron	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	296					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		CTTCAGTTTTCTGGCCAGTAT	0.428	Pancreas(76;29 1355 28675 37177 51207)		NA											9	75					1.76689e-08	2.55257e-08	0.006214	1	0
CRYGA	1418	broad.mit.edu	37	2	209025704	209025704	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:209025704G>C	uc002vcq.3	-	3	366	c.349C>G	c.(349-351)CGT>GGT	p.R117G		NM_014617	NP_055432	P11844	CRGA_HUMAN	crystallin, gamma A	117	Beta/gamma crystallin 'Greek key' 3.				visual perception		structural constituent of eye lens				0				Epithelial(149;0.067)|LUSC - Lung squamous cell carcinoma(261;0.0708)|Lung(261;0.135)		TCAGGGAGACGGAACAGTTCT	0.562			NA											6	48					0	0	0.001168	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209169637	209169637	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:209169637C>T	uc002vcz.2	+	12	1694	c.1536C>T	c.(1534-1536)GCC>GCT	p.A512A	PIKFYVE_uc010fun.1_Silent_p.A193A|PIKFYVE_uc002vcy.1_Intron|PIKFYVE_uc002vcv.2_Silent_p.A415A|PIKFYVE_uc002vcw.2_Silent_p.A512A|PIKFYVE_uc002vcx.2_Silent_p.A426A	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	512					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						GTGACTCAGCCGCTTCTATCA	0.512			NA											8	80					0	0	0.004482	0	0
PTH2R	5746	broad.mit.edu	37	2	209315480	209315480	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:209315480C>A	uc002vdb.2	+	8	1073	c.860C>A	c.(859-861)CCA>CAA	p.P287Q	PTH2R_uc010zjb.1_Missense_Mutation_p.P298Q	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	287	Helical; Name=4; (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		TCAGGGTTTCCAGCAGCATTT	0.408			NA											13	78					0.00010058	0.000124406	0.001368	1	0
NHEJ1	79840	broad.mit.edu	37	2	219942058	219942058	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:219942058G>T	uc002vjp.3	-	7	881	c.735C>A	c.(733-735)TCC>TCA	p.S245S	NHEJ1_uc002vjq.3_RNA	NM_024782	NP_079058	Q9H9Q4	NHEJ1_HUMAN	nonhomologous end-joining factor 1	245					B cell differentiation|central nervous system development|DNA recombination|double-strand break repair via nonhomologous end joining|positive regulation of ligase activity|response to ionizing radiation|T cell differentiation	nonhomologous end joining complex|nucleus	DNA binding|identical protein binding			lung(1)	1		Renal(207;0.0915)		Epithelial(149;2.15e-06)|all cancers(144;0.000339)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0112)		TTCCTTGCAGGGAAGCACTGT	0.463			NA						Direct_reversal_of_damage|NHEJ					6	70					0.00198382	0.00223792	0.001984	1	0
COL6A3	1293	broad.mit.edu	37	2	238285757	238285757	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:238285757T>C	uc002vwl.2	-	7	3013	c.2728A>G	c.(2728-2730)ACG>GCG	p.T910A	COL6A3_uc002vwo.2_Missense_Mutation_p.T704A|COL6A3_uc010znj.1_Missense_Mutation_p.T303A|COL6A3_uc002vwq.2_Missense_Mutation_p.T704A|COL6A3_uc002vwr.2_Missense_Mutation_p.T503A|COL6A3_uc010znk.1_Missense_Mutation_p.T710A	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	910	Nonhelical region.|VWFA 5.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GCTTTGCCCGTCTTGATCTTC	0.517			NA											8	53					0	0	0.00308	0	0
HDAC4	9759	broad.mit.edu	37	2	240085557	240085557	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:240085557C>A	uc002vyk.3	-	6	1345	c.553G>T	c.(553-555)GCG>TCG	p.A185S	HDAC4_uc010fyz.1_Missense_Mutation_p.A180S|HDAC4_uc010zoa.1_Missense_Mutation_p.A180S|HDAC4_uc010fza.2_Missense_Mutation_p.A185S|HDAC4_uc010fyy.2_Missense_Mutation_p.A137S|HDAC4_uc010znz.1_Missense_Mutation_p.A68S	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	185	Interaction with MEF2A.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		TGGGCCAGCGCCTTCTTTTTA	0.572			NA											22	86					1.28384e-07	1.78759e-07	0.001882	1	0
PLCB4	5332	broad.mit.edu	37	20	9459604	9459604	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr20:9459604G>C	uc002wnf.2	+	37	3632	c.3496G>C	c.(3496-3498)GAG>CAG	p.E1166Q	PLCB4_uc010gbx.2_Missense_Mutation_p.E1178Q|PLCB4_uc002wne.2_Missense_Mutation_p.R1178P|PLCB4_uc002wnh.2_Missense_Mutation_p.E1013Q	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	1166					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						ATTGGAAGCCGAGATGGACCG	0.443			NA											5	19					0	0	0.001168	0	0
PAK7	57144	broad.mit.edu	37	20	9624939	9624939	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr20:9624939C>A	uc002wnl.2	-	4	583	c.38G>T	c.(37-39)GGC>GTC	p.G13V	PAK7_uc002wnk.2_Missense_Mutation_p.G13V|PAK7_uc002wnj.2_Missense_Mutation_p.G13V|PAK7_uc010gby.1_Missense_Mutation_p.G13V	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	13	CRIB.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			GTTGGACGGGCCAGATATTTC	0.448			NA											12	59					9.31168e-06	1.23089e-05	0.001855	1	0
TPX2	22974	broad.mit.edu	37	20	30366632	30366632	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr20:30366632G>T	uc002wwp.1	+	10	1597	c.899G>T	c.(898-900)GGA>GTA	p.G300V	TPX2_uc010gdv.1_Missense_Mutation_p.G300V	NM_012112	NP_036244	Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated protein homolog	300					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			large_intestine(1)|ovary(1)	2			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			GTGACTAAGGGATGTACCATT	0.433			NA											15	148					2.35188e-11	3.7952e-11	0.006122	1	0
CBFA2T2	9139	broad.mit.edu	37	20	32162056	32162056	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr20:32162056G>T	uc002wzg.1	+	2	587	c.50G>T	c.(49-51)AGG>ATG	p.R17M	CBFA2T2_uc010zug.1_Intron|CBFA2T2_uc002wze.1_Intron|CBFA2T2_uc002wzf.1_RNA|CBFA2T2_uc002wzh.1_Intron|CBFA2T2_uc002wzi.1_RNA	NM_005093	NP_005084	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit	17						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)|skin(1)	2						GTCCTGGCAAGGCAATGGAAA	0.338	Esophageal Squamous(174;142 1955 14837 21276 28041)		NA											24	75					3.28513e-13	5.44541e-13	0.003954	1	0
CBFA2T2	9139	broad.mit.edu	37	20	32210932	32210932	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr20:32210932C>T	uc002wzg.1	+	6	1086	c.549C>T	c.(547-549)CCC>CCT	p.P183P	CBFA2T2_uc010zug.1_5'UTR|CBFA2T2_uc002wze.1_Silent_p.P174P|CBFA2T2_uc002wzf.1_RNA|CBFA2T2_uc002wzh.1_Silent_p.P154P|CBFA2T2_uc002wzi.1_RNA|CBFA2T2_uc002wzj.1_RNA	NM_005093	NP_005084	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit	183	TAFH.					nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)|skin(1)	2						CCAACCTGCCCCTGCTGCAGC	0.557	Esophageal Squamous(174;142 1955 14837 21276 28041)		NA											4	33					0	0	0.000602	0	0
RPN2	6185	broad.mit.edu	37	20	35826893	35826893	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr20:35826893G>T	uc002xgp.2	+	3	605	c.301G>T	c.(301-303)GAG>TAG	p.E101*	RPN2_uc002xgo.3_Nonsense_Mutation_p.E101*|RPN2_uc010gfw.2_Intron|RPN2_uc002xgq.2_Intron	NM_002951	NP_002942	P04844	RPN2_HUMAN	ribophorin II isoform 1 precursor	101	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CTCAGGATGTGAGGTGAGTCC	0.443			NA											5	63					0.000157383	0.000192065	0.00308	1	0
CHD6	84181	broad.mit.edu	37	20	40045883	40045883	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr20:40045883C>G	uc002xka.1	-	32	6412	c.6234G>C	c.(6232-6234)CAG>CAC	p.Q2078H	CHD6_uc002xjz.1_5'Flank	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2078					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				CCTGTAGCAGCTGAGCAATAG	0.527			NA											8	91					0	0	0.00308	0	0
STK4	6789	broad.mit.edu	37	20	43623806	43623806	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr20:43623806T>C	uc002xnb.2	+	6	691	c.601T>C	c.(601-603)TAC>CAC	p.Y201H	STK4_uc010ggx.2_Missense_Mutation_p.Y201H|STK4_uc010ggy.2_Missense_Mutation_p.Y146H|STK4_uc010ggw.1_Missense_Mutation_p.Y201H	NM_006282	NP_006273	Q13043	STK4_HUMAN	serine/threonine kinase 4	201	Protein kinase.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)				GGAAATTGGATACAACTGTGT	0.448	GBM(187;1039 2137 11798 21916 33213)		NA											10	110					0	0	0.006214	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47604875	47604875	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr20:47604875G>T	uc002xtx.3	+	17	2463	c.2311G>T	c.(2311-2313)GTC>TTC	p.V771F	ARFGEF2_uc010zyf.1_Missense_Mutation_p.V64F	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	771	SEC7.				exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			CACTGCTTATGTCCTAGCGTA	0.383	Esophageal Squamous(176;1738 1974 26285 33069 35354)		NA											7	45					1.12685e-05	1.47621e-05	0.004482	1	0
TPTE	7179	broad.mit.edu	37	21	10969090	10969090	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr21:10969090G>T	uc002yip.1	-	7	526	c.158C>A	c.(157-159)TCA>TAA	p.S53*	TPTE_uc002yis.1_Intron|TPTE_uc002yiq.1_Intron|TPTE_uc002yir.1_Intron|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	53					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACTGATAGGTGACACCCGGGC	0.338			NA											12	233					2.61681e-11	4.18576e-11	0.00245	1	0
BAGE2	85319	broad.mit.edu	37	21	11098714	11098714	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr21:11098714C>A	uc002yit.1	-	1	212	c.4G>T	c.(4-6)GCG>TCG	p.A2S	BAGE_uc002yix.2_RNA	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		actccagccgccatcttactg	0			NA											8	60					0.000274275	0.00032922	0.004482	1	0
KRTAP13-2	337959	broad.mit.edu	37	21	31744512	31744512	+	Missense_Mutation	SNP	G	G	T	rs143324515	byFrequency	TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr21:31744512G>T	uc002ynz.3	-	1	46	c.20C>A	c.(19-21)TCT>TAT	p.S7Y		NM_181621	NP_853652	Q52LG2	KR132_HUMAN	keratin associated protein 13-2	7						intermediate filament					0						GAAGTTTCCAGAGCAGCAGTT	0.502			NA											14	87					1.99824e-07	2.77702e-07	0.00499	1	0
SON	6651	broad.mit.edu	37	21	34923232	34923232	+	Silent	SNP	G	G	T	rs146602176		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr21:34923232G>T	uc002yse.1	+	3	1744	c.1695G>T	c.(1693-1695)TCG>TCT	p.S565S	SON_uc002ysb.1_Silent_p.S565S|SON_uc002ysc.2_Silent_p.S565S|SON_uc002ysd.2_5'UTR|SON_uc002ysf.1_Intron|SON_uc002ysg.2_5'Flank	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	565					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						GGCAGCCTTCGGTGACTGGGG	0.657			NA											9	30					0.00448238	0.00496458	0.004482	1	0
PATZ1	23598	broad.mit.edu	37	22	31740992	31740992	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr22:31740992G>A	uc003akq.2	-	1	1258	c.597C>T	c.(595-597)AGC>AGT	p.S199S	PATZ1_uc003akp.2_Silent_p.S199S|PATZ1_uc003akr.2_Silent_p.S199S|PATZ1_uc003aks.2_Silent_p.S199S|uc003akt.2_5'Flank	NM_014323	NP_055138	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	199					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	soft_tissue(2)	2						CGATGCCATTGCTGTTGGCTG	0.647			NA											17	27					0	0	0.004007	0	0
SOX10	6663	broad.mit.edu	37	22	38369875	38369876	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr22:38369875_38369876GG>TT	uc003aun.1	-	4	1305_1306	c.1027_1028CC>AA	c.(1027-1029)CCC>AAC	p.P343N	POLR2F_uc003aum.2_Intron|SOX10_uc003auo.1_Missense_Mutation_p.P343N	NM_006941	NP_008872	P56693	SOX10_HUMAN	SRY (sex determining region Y)-box 10	343						cytoplasm|nucleus	DNA binding|identical protein binding|transcription coactivator activity				0	Melanoma(58;0.045)					TGAGACCGTGGGCAGAGCCACG	0.668	Melanoma(39;342 1098 6220 32775 40068)|GBM(21;140 497 5227 16059 19275)		NA											7	25					0	0	0.004672	0	0
SBF1	6305	broad.mit.edu	37	22	50902833	50902833	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr22:50902833G>A	uc003blh.2	-	15	1869	c.1674C>T	c.(1672-1674)AAC>AAT	p.N558N	SBF1_uc011arx.1_Silent_p.N222N|SBF1_uc003bli.2_Silent_p.N559N	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	558					protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		GCCGGGCGCTGTTGACATGCA	0.637			NA											9	22					0	0	0.004482	0	0
CNTN4	152330	broad.mit.edu	37	3	2924927	2924927	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:2924927G>T	uc003bpc.2	+	8	972	c.751G>T	c.(751-753)GGA>TGA	p.G251*	CNTN4_uc003bpb.1_Intron|CNTN4_uc003bpd.1_Nonsense_Mutation_p.G251*	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	251	Ig-like C2-type 3.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		CTTTGCTTTAGGAAAGTAAGT	0.463			NA											4	26					0.00024832	0.000299541	0.009096	1	0
IL17RE	132014	broad.mit.edu	37	3	9952837	9952838	+	Missense_Mutation	DNP	GC	GC	AT			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:9952837_9952838GC>AT	uc003btu.2	+	11	1122_1123	c.1005_1006GC>AT	c.(1003-1008)CTGCAC>CTATAC	p.H336Y	CIDEC_uc003bto.2_Intron|IL17RE_uc011atn.1_RNA|IL17RE_uc003btw.2_Missense_Mutation_p.H336Y|IL17RE_uc003btx.2_Missense_Mutation_p.H220Y|IL17RE_uc010hcq.2_Missense_Mutation_p.H336Y|IL17RE_uc003bty.2_RNA	NM_153483	NP_705616	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E isoform 1	336	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane	receptor activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		AGGTGGACCTGCACCCCCAGCT	0.54			NA											16	141					0	0	0.004672	0	0
SH3BP5	9467	broad.mit.edu	37	3	15311335	15311335	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:15311335T>A	uc003bzp.1	-	4	569	c.380A>T	c.(379-381)GAG>GTG	p.E127V	SH3BP5_uc010hem.1_Intron|SH3BP5_uc003bzq.1_5'UTR|SH3BP5_uc003bzr.1_5'UTR	NM_004844	NP_004835	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	127					intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding				0						ACGGAGCACCTCTGTGGCCCT	0.612			NA											27	123					0	0	0.003271	0	0
GADL1	339896	broad.mit.edu	37	3	30880603	30880603	+	Silent	SNP	C	C	A	rs148436135		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:30880603C>A	uc003cep.2	-	9	836	c.789G>T	c.(787-789)GGG>GGT	p.G263G	GADL1_uc003ceq.1_Silent_p.G263G	NM_207359	NP_997242	Q6ZQY3	GADL1_HUMAN	glutamate decarboxylase-like 1	263					carboxylic acid metabolic process		carboxy-lyase activity|pyridoxal phosphate binding				0					Pyridoxal Phosphate(DB00114)	ACGGTGCTGCCCCCTGTAAGA	0.448			NA											13	54					1.5842e-08	2.29772e-08	0.001855	1	0
MLH1	4292	broad.mit.edu	37	3	37038135	37038135	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:37038135C>G	uc003cgl.2	+	2	202	c.142C>G	c.(142-144)CAA>GAA	p.Q48E	MLH1_uc011aye.1_5'UTR|MLH1_uc011ayb.1_Intron|MLH1_uc010hge.2_Missense_Mutation_p.Q48E|MLH1_uc003cgn.3_5'UTR|MLH1_uc011ayc.1_5'UTR|MLH1_uc011ayd.1_5'UTR|MLH1_uc003cgo.2_5'UTR	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	48					mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding			large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						CACAAGTATTCAAGTGATTGT	0.378			1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				8	55					0	0	0.00308	0	0
SCN10A	6336	broad.mit.edu	37	3	38760296	38760296	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:38760296C>A	uc003ciq.2	-	20	3529	c.3529G>T	c.(3529-3531)GAC>TAC	p.D1177Y		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1177	III.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGCTTCTGGTCCAGGTAATAG	0.532			NA											10	25					2.17888e-05	2.81406e-05	0.006214	1	0
SCN11A	11280	broad.mit.edu	37	3	38936142	38936142	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:38936142G>T	uc011ays.1	-	15	2916	c.2717C>A	c.(2716-2718)ACC>AAC	p.T906N	SCN11A_uc010hhn.1_Missense_Mutation_p.T22N	NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	906					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GACGCCCAGGGTCTTTGGTAC	0.502			NA											15	107					6.31663e-08	8.93125e-08	0.003163	1	0
RPL14	9045	broad.mit.edu	37	3	40503438	40503438	+	Silent	SNP	A	A	G	rs145518013		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:40503438A>G	uc003ckg.2	+	6	414	c.363A>G	c.(361-363)AGA>AGG	p.R121R	RPL14_uc003ckh.2_Silent_p.R121R|RPL14_uc003cki.2_Silent_p.R72R	NM_003973	NP_003964	P50914	RL14_HUMAN	ribosomal protein L14	121					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		AGAGGAACAGAATAATCAAGA	0.318			NA											3	32					0	0	0.004672	0	0
MST1R	4486	broad.mit.edu	37	3	49928939	49928939	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:49928939C>T	uc003cxy.3	-	16	3691	c.3427G>A	c.(3427-3429)GTG>ATG	p.V1143M	MST1R_uc011bdc.1_Missense_Mutation_p.V22M	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1143	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		AGAGCCAGCACATTCGGGTGG	0.607			NA											16	51					0	0	0.007413	0	0
NEK4	6787	broad.mit.edu	37	3	52802407	52802407	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:52802407G>A	uc003dfq.3	-	2	496	c.307C>T	c.(307-309)CTG>TTG	p.L103L	NEK4_uc011bej.1_Intron|NEK4_uc003dfr.2_Silent_p.L103L	NM_003157	NP_003148	P51957	NEK4_HUMAN	NIMA-related kinase 4	103	Protein kinase.				cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		TTCTCAGGCAGAAGCTGCCCT	0.498			NA											18	212					0	0	0.007413	0	0
FAM86D	692099	broad.mit.edu	37	3	75476723	75476723	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:75476723C>A	uc003dpp.3	-	6	701	c.342G>T	c.(340-342)GGG>GGT	p.G114G	FAM86D_uc003dpo.3_Intron|FAM86D_uc003dps.3_Intron|FAM86D_uc003dpq.3_Silent_p.G22G|FAM86D_uc003dpr.3_Intron	NR_024241				RecName: Full=Protein FAM86B1;												0						GAAGGACATTCCCTCGGAGCT	0.612			NA											5	39					1.12685e-05	1.47621e-05	0.004482	1	0
EPHA3	2042	broad.mit.edu	37	3	89390204	89390204	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:89390204C>A	uc003dqy.2	+	4	1178	c.953C>A	c.(952-954)CCA>CAA	p.P318Q	EPHA3_uc003dqx.1_Missense_Mutation_p.P318Q|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	318	Extracellular (Potential).|Cys-rich.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		AAAGACCCTCCATCCATGGCT	0.443			NA								TSP Lung(6;0.00050)			18	137					5.03518e-11	8.019e-11	0.007413	1	0
EPHA3	2042	broad.mit.edu	37	3	89391113	89391113	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:89391113G>T	uc003dqy.2	+	5	1404	c.1179G>T	c.(1177-1179)ACG>ACT	p.T393T	EPHA3_uc003dqx.1_Silent_p.T393T|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	393	Extracellular (Potential).|Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding	p.T393K(1)		lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CCAACACCACGGTGACAGTGA	0.483			NA								TSP Lung(6;0.00050)			16	46					6.31663e-08	8.93125e-08	0.003163	1	0
CPOX	1371	broad.mit.edu	37	3	98299562	98299563	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:98299562_98299563CC>AA	uc003dsx.2	-	7	1422_1423	c.1329_1330GG>TT	c.(1327-1332)CTGGAA>CTTTAA	p.E444*		NM_000097	NP_000088	P36551	HEM6_HUMAN	coproporphyrinogen oxidase precursor	444						mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity				0						CGTAGAACTTCCAGAATTTCAG	0.485	Esophageal Squamous(75;7 1223 22300 43648 48951)		NA											3	43					0	0	0.004672	0	0
POLQ	10721	broad.mit.edu	37	3	121208671	121208671	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:121208671C>T	uc003eee.3	-	16	3236	c.3107G>A	c.(3106-3108)AGC>AAC	p.S1036N	POLQ_uc003eed.2_Missense_Mutation_p.S208N	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1036					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		AAAACTTCTGCTCATCTTTTC	0.408	Pancreas(152;907 1925 26081 31236 36904)		NA						DNA_polymerases_(catalytic_subunits)					5	77					0	0	0.000602	0	0
GOLGB1	2804	broad.mit.edu	37	3	121411320	121411320	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:121411320C>A	uc003eei.3	-	14	7002	c.6876G>T	c.(6874-6876)CAG>CAT	p.Q2292H	GOLGB1_uc010hrc.2_Missense_Mutation_p.Q2297H|GOLGB1_uc003eej.3_Missense_Mutation_p.Q2258H	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2292	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TCTCTTCTAGCTGGGACAAAA	0.443			NA											15	88					1.15088e-07	1.60552e-07	0.004007	1	0
CASR	846	broad.mit.edu	37	3	121980463	121980463	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:121980463C>T	uc003eev.3	+	4	953	c.581C>T	c.(580-582)GCC>GTC	p.A194V	CASR_uc003eew.3_Missense_Mutation_p.A194V	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	194	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GAGCACCAGGCCACTGCCATG	0.532			NA											51	109					0	0	0.00361	0	0
PARP14	54625	broad.mit.edu	37	3	122432421	122432421	+	Splice_Site	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:122432421G>T	uc003efq.3	+	10	3828	c.3769_splice	c.e10+1	p.G1257_splice	PARP14_uc010hrk.2_Splice_Site|PARP14_uc003efr.2_Splice_Site_p.G974_splice|PARP14_uc003efs.1_Splice_Site_p.G974_splice	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		CTCAAAGCAGGTACTTGTACA	0.373			NA											17	40					7.21436e-19	1.27077e-18	0.008871	1	0
KALRN	8997	broad.mit.edu	37	3	124066000	124066000	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:124066000G>A	uc003ehg.2	+	10	1779	c.1652G>A	c.(1651-1653)TGG>TAG	p.W551*	KALRN_uc010hrv.1_Nonsense_Mutation_p.W551*|KALRN_uc003ehf.1_Nonsense_Mutation_p.W551*|KALRN_uc011bjy.1_Nonsense_Mutation_p.W551*	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	551	Spectrin 3.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GTGTTGGACTGGATTGAAAAC	0.488			NA											45	142					0	0	0.00361	0	0
ACPP	55	broad.mit.edu	37	3	132063770	132063770	+	Splice_Site	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:132063770G>C	uc010htp.2	+	7	739	c.649_splice	c.e7-1	p.S217_splice	ACPP_uc003eon.3_Splice_Site_p.S184_splice|ACPP_uc003eop.3_Splice_Site_p.S217_splice	NM_001099	NP_001090	P15309	PPAP_HUMAN	acid phosphatase, prostate short isoform							extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			ovary(1)	1						CTTTGCTACAGAGTGTTCACA	0.413			NA											5	75					0	0	0.001168	0	0
COPB2	9276	broad.mit.edu	37	3	139096978	139096978	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:139096978C>G	uc003etf.3	-	5	539	c.409G>C	c.(409-411)GTG>CTG	p.V137L	COPB2_uc011bmv.1_Missense_Mutation_p.V108L|COPB2_uc010hui.2_Missense_Mutation_p.V108L|COPB2_uc011bmw.1_Missense_Mutation_p.V137L	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	137					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						CCTTCAAACACTTGTGAGCAA	0.398			NA											61	177					0	0	0.00361	0	0
TRIM42	287015	broad.mit.edu	37	3	140406835	140406835	+	Silent	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:140406835T>C	uc003eto.1	+	3	1502	c.1311T>C	c.(1309-1311)ACT>ACC	p.T437T		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	437	COS.					intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						TGAAGGAGACTGGCCAGGTGG	0.537			NA											11	25					0	0	0.008291	0	0
P2RY12	64805	broad.mit.edu	37	3	151055929	151055929	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:151055929G>A	uc003eyw.1	-	2	921	c.705C>T	c.(703-705)AAC>AAT	p.N235N	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron|P2RY12_uc011boa.1_3'UTR|P2RY12_uc003eyx.1_Silent_p.N235N	NM_176876	NP_795345	Q9H244	P2Y12_HUMAN	purinergic receptor P2Y12	235	Helical; Name=6; (Potential).				platelet activation	integral to membrane|plasma membrane	guanyl-nucleotide exchange factor activity			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)		Clopidogrel(DB00758)|Epoprostenol(DB01240)|Ticlopidine(DB00208)|Treprostinil(DB00374)	AAACTTTGACGTTCACCTTTT	0.388			NA											12	55					0	0	0.001368	0	0
MED12L	116931	broad.mit.edu	37	3	151102898	151102898	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:151102898C>T	uc003eyp.2	+	34	4940	c.4902C>T	c.(4900-4902)GTC>GTT	p.V1634V	MED12L_uc011bnz.1_Silent_p.V1494V|P2RY12_uc011boa.1_5'Flank|P2RY12_uc003eyx.1_5'Flank|MED12L_uc003eyy.1_Silent_p.V797V	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1634					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CATGTGATGTCATCACTTGTG	0.368			NA											19	158					0	0	0.010504	0	0
GPR149	344758	broad.mit.edu	37	3	154055989	154055989	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:154055989C>T	uc003faa.2	-	4	1795	c.1695G>A	c.(1693-1695)GGG>GGA	p.G565G		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	565	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			ATAGGGTTTTCCCTGTAGGTG	0.453			NA											29	181					0	0	0.009535	0	0
EIF4A2	1974	broad.mit.edu	37	3	186504993	186504993	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:186504993G>T	uc003fqs.2	+	8	888	c.849G>T	c.(847-849)AGG>AGT	p.R283S	EIF4A2_uc003fqt.2_RNA|EIF4A2_uc003fqu.2_Missense_Mutation_p.R284S|EIF4A2_uc003fqv.2_Missense_Mutation_p.R188S|EIF4A2_uc003fqw.2_Missense_Mutation_p.R188S|EIF4A2_uc011bsb.1_Missense_Mutation_p.R156S|SNORA63_uc010hyw.1_5'Flank|SNORA4_uc010hyx.1_5'Flank	NM_001967	NP_001958	Q14240	IF4A2_HUMAN	eukaryotic translation initiation factor 4A2	283	Helicase C-terminal.				interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|protein binding|translation initiation factor activity			ovary(2)|breast(2)	4	all_cancers(143;2.68e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.07e-20)	GBM - Glioblastoma multiforme(93;0.0704)		TCAATACGAGGCGCAAGGTGG	0.423			NA	T	BCL6	NHL								39	99					3.66082e-28	6.67346e-28	0.005524	1	0
CRIPAK	285464	broad.mit.edu	37	4	1389358	1389358	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:1389358G>T	uc003gdf.2	+	1	4019	c.1059G>T	c.(1057-1059)CTG>CTT	p.L353L		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	353					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			GTGCCCGCCTGCTCACACGTG	0.662			NA											26	151					1.39806e-14	2.37669e-14	0.008361	1	0
SLIT2	9353	broad.mit.edu	37	4	20619120	20619120	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:20619120G>A	uc003gpr.1	+	36	4399	c.4195G>A	c.(4195-4197)GAG>AAG	p.E1399K	SLIT2_uc003gps.1_Missense_Mutation_p.E1391K	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1399					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						TAAGTGCTTGGAGGGCCATGG	0.537			NA											7	35					0	0	0.004482	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23816048	23816048	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:23816048T>A	uc003gqs.2	-	8	1178	c.1058A>T	c.(1057-1059)GAG>GTG	p.E353V	PPARGC1A_uc003gqt.2_RNA|PPARGC1A_uc011bxp.1_RNA|PPARGC1A_uc010ier.1_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	353					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				TGCATACAACTCGGATTGCTC	0.532	Esophageal Squamous(29;694 744 13796 34866 44181)		NA											21	139					0	0	0.001882	0	0
STIM2	57620	broad.mit.edu	37	4	27019384	27019384	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:27019384G>T	uc003gsh.3	+	12	2042	c.1826G>T	c.(1825-1827)CGT>CTT	p.R609L	STIM2_uc003gsg.3_Missense_Mutation_p.R601L|STIM2_uc010iex.2_Missense_Mutation_p.R601L|STIM2_uc010iey.2_Missense_Mutation_p.R225L	NM_020860	NP_065911	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	514	Cytoplasmic (Potential).				activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			central_nervous_system(1)|skin(1)	2		Breast(46;0.0503)				AGCCTGTGCCGTTCACGCCGC	0.597			NA											26	147					4.59853e-10	7.03248e-10	0.005443	1	0
TLR10	81793	broad.mit.edu	37	4	38777210	38777210	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:38777210A>G	uc003gti.2	-	2	381	c.2T>C	c.(1-3)ATG>ACG	p.M1T	TLR10_uc003gtj.2_Missense_Mutation_p.M1T|TLR10_uc003gtk.2_Missense_Mutation_p.M1T	NM_030956	NP_112218	Q9BXR5	TLR10_HUMAN	toll-like receptor 10 precursor	1					inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			lung(1)|breast(1)	2						GATGAGTCTCATTGTATTTCC	0.343			NA											10	33					0	0	0.006214	0	0
FRYL	285527	broad.mit.edu	37	4	48512111	48512111	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:48512111C>T	uc003gyh.1	-	59	8964	c.8359G>A	c.(8359-8361)GAT>AAT	p.D2787N	FRYL_uc003gyf.1_Missense_Mutation_p.D183N|FRYL_uc003gyg.1_Missense_Mutation_p.D1483N	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2787					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						TTGTATGTATCCAGGTGTTCT	0.438			NA											7	49					0	0	0.00308	0	0
LPHN3	23284	broad.mit.edu	37	4	62862036	62862036	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:62862036C>T	uc010ihh.2	+	17	3233	c.3060C>T	c.(3058-3060)TTC>TTT	p.F1020F	LPHN3_uc003hcq.3_Silent_p.F1020F|LPHN3_uc003hct.2_Silent_p.F413F	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	1007	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						ACACCTACTTCATTTGGAGTT	0.393			NA											16	129					0	0	0.00499	0	0
LPHN3	23284	broad.mit.edu	37	4	62894601	62894601	+	Splice_Site	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:62894601T>A	uc010ihh.2	+	19	3391	c.3218_splice	c.e19+2	p.K1073_splice	LPHN3_uc003hcq.3_Splice_Site_p.K1073_splice|LPHN3_uc003hct.2_Intron	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						CTTCATCAAGTAAGAATGACC	0.358			NA											3	17					0	0	0.004672	0	0
UGT2A3	79799	broad.mit.edu	37	4	69795752	69795752	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:69795752G>T	uc003hef.2	-	6	1394	c.1363C>A	c.(1363-1365)CTA>ATA	p.L455I	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	455	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						GCTCGATCTAGGGGCTTTACA	0.453			NA											16	94					2.48551e-13	4.16721e-13	0.00499	1	0
UGT2A3	79799	broad.mit.edu	37	4	69817245	69817245	+	Silent	SNP	A	A	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:69817245A>G	uc003hef.2	-	1	265	c.234T>C	c.(232-234)CAT>CAC	p.H78H	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	78	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						CCTGTGGCATATGGACCACCT	0.403			NA											10	76					0	0	0.006214	0	0
UGT2B28	54490	broad.mit.edu	37	4	70152549	70152549	+	Missense_Mutation	SNP	C	C	A	rs144043239		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:70152549C>A	uc003hej.2	+	3	952	c.950C>A	c.(949-951)ACA>AAA	p.T317K	UGT2B28_uc010ihr.2_Missense_Mutation_p.T317K	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	317					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	AGTAACATGACAGCAGAAAGG	0.418			NA											12	101					9.31168e-06	1.23089e-05	0.001855	1	0
PROL1	58503	broad.mit.edu	37	4	71275358	71275358	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:71275358C>A	uc003hfi.2	+	3	487	c.313C>A	c.(313-315)CTA>ATA	p.L105I		NM_021225	NP_067048	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	105	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			large_intestine(1)	1		all_hematologic(202;0.196)				TTATCCAAACCTACATTTCCC	0.388			NA											35	206					4.10981e-09	6.10625e-09	0.005524	1	0
ANKRD17	26057	broad.mit.edu	37	4	73984548	73984548	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:73984548G>A	uc003hgp.2	-	22	4162	c.4045C>T	c.(4045-4047)CGT>TGT	p.R1349C	ANKRD17_uc003hgo.2_Missense_Mutation_p.R1236C|ANKRD17_uc003hgq.2_Missense_Mutation_p.R1098C|ANKRD17_uc003hgr.2_Missense_Mutation_p.R1348C|ANKRD17_uc011cbd.1_Missense_Mutation_p.R914C	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1349					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TTCTTGTTACGTACATCAATA	0.358			NA											17	114					0	0	0.007413	0	0
STBD1	8987	broad.mit.edu	37	4	77231140	77231140	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:77231140G>T	uc003hka.2	+	2	1310	c.1064G>T	c.(1063-1065)TGG>TTG	p.W355L	STBD1_uc003hjy.2_3'UTR|STBD1_uc011cbv.1_3'UTR|STBD1_uc011cbw.1_Missense_Mutation_p.W206L	NM_003943	NP_003934	O95210	STBD1_HUMAN	starch binding domain 1	355	CBM20.|Cytoplasmic (Potential).				carbohydrate metabolic process|muscle contraction	integral to plasma membrane|membrane fraction	carbohydrate binding|catalytic activity|protein binding			ovary(1)	1			Lung(101;0.196)			CACGCATGGTGGGGGATTCAC	0.448			NA											17	81					1.33834e-09	2.02552e-09	0.007413	1	0
HELQ	113510	broad.mit.edu	37	4	84374799	84374799	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:84374799C>A	uc003hom.2	-	2	776	c.597G>T	c.(595-597)CAG>CAT	p.Q199H	HELQ_uc010ikb.2_Missense_Mutation_p.Q199H|HELQ_uc003hol.3_RNA|HELQ_uc010ikc.2_RNA|HELQ_uc003hon.1_Missense_Mutation_p.Q93H|HELQ_uc003hoo.1_Missense_Mutation_p.Q162H|HELQ_uc003hop.1_Missense_Mutation_p.Q93H|HELQ_uc003hoq.1_Missense_Mutation_p.Q199H|MRPS18C_uc003hor.3_5'Flank|MRPS18C_uc011ccu.1_5'Flank	NM_133636	NP_598375	Q8TDG4	HELQ_HUMAN	DNA helicase HEL308	199							ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|breast(1)|skin(1)	3						AGTATATAGCCTGTGAGGAAG	0.388			NA						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					41	130					7.53189e-24	1.35611e-23	0.007835	1	0
ABCG2	9429	broad.mit.edu	37	4	89018658	89018658	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:89018658T>A	uc003hrg.2	-	13	2087	c.1594A>T	c.(1594-1596)AGT>TGT	p.S532C	ABCG2_uc003hrh.2_Missense_Mutation_p.S532C|ABCG2_uc003hrf.2_Missense_Mutation_p.S400C	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G, member 2	532	ABC transmembrane type-2.|Cytoplasmic (Potential).				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	GAAACCACACTCTGACCTGCT	0.428			NA											15	48					0	0	0.00499	0	0
ADH6	130	broad.mit.edu	37	4	100131611	100131611	+	Missense_Mutation	SNP	G	G	T	rs148378840	byFrequency	TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:100131611G>T	uc003hup.3	-	4	405	c.311C>A	c.(310-312)TCT>TAT	p.S104Y	uc003hum.1_Intron|ADH6_uc003huo.2_Missense_Mutation_p.S104Y|ADH6_uc011cef.1_5'UTR|ADH6_uc010ile.2_Missense_Mutation_p.S104Y	NM_000672	NP_000663	P28332	ADH6_HUMAN	class V alcohol dehydrogenase isoform 2	104					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	ATTCAGGCAAGAGGTACATTC	0.299			NA											14	110					2.23348e-06	3.02909e-06	0.004007	1	0
AGXT2L1	64850	broad.mit.edu	37	4	109664984	109664984	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:109664984G>T	uc003hzc.2	-	12	1513	c.1332C>A	c.(1330-1332)ACC>ACA	p.T444T	AGXT2L1_uc010imc.2_Silent_p.T438T|AGXT2L1_uc011cfm.1_Silent_p.T404T|AGXT2L1_uc011cfn.1_Silent_p.T371T|AGXT2L1_uc011cfo.1_Silent_p.T386T	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1	444					cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		TCACACTTTCGGTTTTGGTTC	0.328			NA											18	73					3.62473e-10	5.59004e-10	0.001882	1	0
NEUROG2	63973	broad.mit.edu	37	4	113436287	113436287	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:113436287C>A	uc003ias.2	-	2	672	c.345G>T	c.(343-345)CTG>CTT	p.L115L		NM_024019	NP_076924	Q9H2A3	NGN2_HUMAN	neurogenin 2	115	Helix-loop-helix motif.				positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent	nucleus	E-box binding			skin(2)|central_nervous_system(1)	3		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.00168)		TGTTGGCCTTCAGTCTACGGG	0.667			NA											13	26					7.03913e-09	1.03118e-08	0.001368	1	0
ANK2	287	broad.mit.edu	37	4	114275674	114275674	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:114275674G>C	uc003ibe.3	+	38	6000	c.5900G>C	c.(5899-5901)GGC>GCC	p.G1967A	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.G1982A	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1934	Repeat-rich region.|Repeat A.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TCACCTTCTGGCAAAACAGAA	0.498			NA											19	101					0	0	0.006122	0	0
TMEM155	132332	broad.mit.edu	37	4	122682991	122682991	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:122682991G>T	uc003idx.1	-	4	607	c.48C>A	c.(46-48)TCC>TCA	p.S16S	TMEM155_uc003idy.1_Silent_p.S16S	NM_152399	NP_689612	Q4W5P6	TM155_HUMAN	transmembrane protein 155 precursor	16						extracellular region					0						TTACAAGTTTGGAAATTAGTG	0.333			NA											15	34					9.16793e-09	1.33768e-08	0.00499	1	0
PCDH18	54510	broad.mit.edu	37	4	138451195	138451195	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:138451195A>T	uc003ihe.3	-	1	2435	c.2048T>A	c.(2047-2049)GTG>GAG	p.V683E	PCDH18_uc003ihf.3_Missense_Mutation_p.V676E|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.V463E|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	683	Cadherin 6.|Extracellular (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					TGTACTTGTCACCGACTCTGC	0.418			NA											61	146					0	0	0.00361	0	0
INPP4B	8821	broad.mit.edu	37	4	143081565	143081565	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:143081565C>T	uc003iix.3	-	18	2104	c.1509G>A	c.(1507-1509)GTG>GTA	p.V503V	INPP4B_uc003iiw.3_Silent_p.V503V|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_Silent_p.V318V|INPP4B_uc011cho.1_RNA|INPP4B_uc011chp.1_Silent_p.V374V	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	503					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					GCCCTCTCATCACTGGGGGTT	0.498			NA											20	121					0	0	0.010504	0	0
FBXW7	55294	broad.mit.edu	37	4	153253847	153253847	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:153253847G>A	uc003ims.2	-	6	1035	c.886C>T	c.(886-888)CTG>TTG	p.L296L	FBXW7_uc011cii.1_Silent_p.L296L|FBXW7_uc003imt.2_Silent_p.L296L|FBXW7_uc011cih.1_Silent_p.L120L|FBXW7_uc003imq.2_Silent_p.L216L|FBXW7_uc003imr.2_Silent_p.L178L	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	296	F-box.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TTGGGTTCCAGGAATGAAAGC	0.348			NA	Mis|N|D|F		colorectal|endometrial|T-ALL								6	57					0	0	0.001168	0	0
GRIA2	2891	broad.mit.edu	37	4	158142240	158142240	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:158142240T>A	uc003ipm.3	+	1	505	c.46T>A	c.(46-48)TGG>AGG	p.W16R	GRIA2_uc011cit.1_Intron|GRIA2_uc003ipl.3_Missense_Mutation_p.W16R|GRIA2_uc003ipk.3_Intron|GRIA2_uc010iqh.1_5'Flank	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	16					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	TCCTGTTTTATGGGGACTGAT	0.368			NA											25	194					0	0	0.005443	0	0
NPY5R	4889	broad.mit.edu	37	4	164271912	164271912	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:164271912G>T	uc003iqn.2	+	4	669	c.487G>T	c.(487-489)GTC>TTC	p.V163F		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	163	Helical; Name=4; (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				GATAGCTACTGTCTGGACACT	0.378	Melanoma(139;1287 1774 9781 19750 25599)		NA											78	220					6.16549e-39	1.13812e-38	0.00361	1	0
TKTL2	84076	broad.mit.edu	37	4	164394505	164394505	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:164394505G>C	uc003iqp.3	-	1	543	c.382C>G	c.(382-384)CAG>GAG	p.Q128E		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	128						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CCTAATCCCTGACCTAGGGAC	0.527			NA											9	53					0	0	0.004482	0	0
ANP32C	23520	broad.mit.edu	37	4	165118545	165118545	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:165118545G>A	uc011cjk.1	-	1	319	c.319C>T	c.(319-321)CAG>TAG	p.Q107*	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	107	LRR 3.										0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		TTTTCTAACTGTTTCAGTGGC	0.433			NA											22	146					0	0	0.00278	0	0
ODZ3	55714	broad.mit.edu	37	4	183522218	183522218	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:183522218C>A	uc003ivd.1	+	3	690	c.653C>A	c.(652-654)CCG>CAG	p.P218Q		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	218	Cytoplasmic (Potential).|Teneurin N-terminal.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		AGTCCGGCCCCGCCGGCTGCT	0.572			NA											13	84					1.5842e-08	2.29772e-08	0.001855	1	0
FAT1	2195	broad.mit.edu	37	4	187558005	187558005	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:187558005G>A	uc003izf.2	-	5	3894	c.3706C>T	c.(3706-3708)CTT>TTT	p.L1236F		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1236	Extracellular (Potential).|Cadherin 10.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TTTTCATCAAGGATTTTCACA	0.398	Colon(197;1040 2055 4143 4984 49344)		NA								HNSCC(5;0.00058)			33	253					0	0	0.002445	0	0
TRIML2	205860	broad.mit.edu	37	4	189026059	189026059	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:189026059A>C	uc003izl.2	-	2	103	c.67T>G	c.(67-69)TCG>GCG	p.S23A	TRIML2_uc011cle.1_Missense_Mutation_p.S73A|TRIML2_uc011clf.1_Missense_Mutation_p.S73A	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	23	Potential.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		TTCTCCCTCGATGTGTTCAAT	0.408			NA											10	98					0	0	0.008291	0	0
ADCY2	108	broad.mit.edu	37	5	7773210	7773210	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:7773210G>A	uc003jdz.1	+	18	2447	c.2380G>A	c.(2380-2382)GAG>AAG	p.E794K	ADCY2_uc011cmo.1_Missense_Mutation_p.E614K	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	794					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GGTCTTATTTGAGAGGTGAGC	0.507			NA											4	72					0	0	0.000602	0	0
FAM173B	134145	broad.mit.edu	37	5	10239183	10239183	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:10239183C>A	uc003jeo.2	-	2	331	c.302G>T	c.(301-303)CGC>CTC	p.R101L	FAM173B_uc003jep.2_RNA|FAM173B_uc010itr.2_Missense_Mutation_p.R101L	NM_199133	NP_954584	Q6P4H8	F173B_HUMAN	hypothetical protein LOC134145	101						integral to membrane				kidney(1)|central_nervous_system(1)	2						ACTCACAATGCGTCCGTCCCC	0.398			NA											14	97					1.5739e-10	2.46892e-10	0.004007	1	0
CTNND2	1501	broad.mit.edu	37	5	11411693	11411693	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:11411693G>T	uc003jfa.1	-	5	539	c.394C>A	c.(394-396)CAG>AAG	p.Q132K	CTNND2_uc010itt.2_Missense_Mutation_p.Q41K|CTNND2_uc011cmy.1_Missense_Mutation_p.Q41K|CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	132					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CCTGATTCCTGTAGTGACCTA	0.383			NA											17	114					2.48551e-13	4.16721e-13	0.00499	1	0
FBXL7	23194	broad.mit.edu	37	5	15928432	15928432	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:15928432G>T	uc003jfn.1	+	3	1042	c.561G>T	c.(559-561)ATG>ATT	p.M187I		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	187	LRR 1.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						TGTGTCTCATGCTGGAAACCG	0.632			NA											3	19					0.00909568	0.00987956	0.009096	1	0
CDH18	1016	broad.mit.edu	37	5	19520818	19520818	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:19520818T>G	uc003jgc.2	-	9	1837	c.1460A>C	c.(1459-1461)GAA>GCA	p.E487A	CDH18_uc003jgd.2_Missense_Mutation_p.E487A|CDH18_uc011cnm.1_Missense_Mutation_p.E487A	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	487	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CCTGGCAAGTTCGGGTGGATT	0.378			NA											8	104					0	0	0.008291	0	0
PRDM9	56979	broad.mit.edu	37	5	23526942	23526942	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:23526942G>T	uc003jgo.2	+	11	1927	c.1745G>T	c.(1744-1746)TGC>TTC	p.C582F		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	582	C2H2-type 4.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CCCTATGTCTGCAGGGAGTGT	0.597			NA								HNSCC(3;0.000094)			23	54					3.73988e-18	6.55601e-18	0.00632	1	0
PDZD2	23037	broad.mit.edu	37	5	32073957	32073957	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:32073957A>T	uc003jhl.2	+	18	3133	c.2745A>T	c.(2743-2745)AAA>AAT	p.K915N	PDZD2_uc003jhm.2_Missense_Mutation_p.K915N|PDZD2_uc011cnx.1_Missense_Mutation_p.K741N	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	915					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						AGCCTGGAAAACCCAGAGCCA	0.557			NA											4	91					0	0	0.001168	0	0
RXFP3	51289	broad.mit.edu	37	5	33937275	33937275	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:33937275C>G	uc003jic.1	+	1	787	c.430C>G	c.(430-432)CTT>GTT	p.L144V		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	144	Extracellular (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						GGAGAACGCTCTTGACTTCAA	0.562			NA											3	105					0	0	0.009096	0	0
RXFP3	51289	broad.mit.edu	37	5	33938220	33938220	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:33938220C>T	uc003jic.1	+	1	1732	c.1375C>T	c.(1375-1377)CGC>TGC	p.R459C		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	459	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						CAGCGGGGGGCGCTACGACCT	0.597			NA											4	20					0	0	0.000602	0	0
FYB	2533	broad.mit.edu	37	5	39134992	39134992	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:39134992T>A	uc003jls.2	-	7	1707	c.1640A>T	c.(1639-1641)GAA>GTA	p.E547V	FYB_uc003jlt.2_Missense_Mutation_p.E547V|FYB_uc003jlu.2_Missense_Mutation_p.E547V|FYB_uc011cpl.1_Missense_Mutation_p.E557V	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	547	SH3.				cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			CCATTTTCCTTCTGGGTTGTC	0.413			NA											25	43					0	0	0.004656	0	0
ZNF131	7690	broad.mit.edu	37	5	43174960	43174960	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:43174960G>A	uc011cpw.1	+	7	1633	c.1597G>A	c.(1597-1599)GAA>AAA	p.E533K	ZNF131_uc003jnj.3_Missense_Mutation_p.E254K|ZNF131_uc003jnk.2_Missense_Mutation_p.E499K|ZNF131_uc003jnn.3_Missense_Mutation_p.E254K|ZNF131_uc003jnl.1_Intron|ZNF131_uc010ivm.1_Intron	NM_003432	NP_003423	P52739	ZN131_HUMAN	zinc finger protein 131	533						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AATTCAGACTGAAGAAGGTAC	0.478			NA											6	44					0	0	0.001168	0	0
ITGA2	3673	broad.mit.edu	37	5	52377468	52377468	+	Missense_Mutation	SNP	G	G	T	rs139705254		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:52377468G>T	uc003joy.2	+	26	3229	c.3086G>T	c.(3085-3087)GGA>GTA	p.G1029V	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.G953V|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	1029	Extracellular (Potential).				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				CTGAAAATAGGACAAACATCT	0.373			NA											8	28					5.68852e-11	8.98123e-11	0.004482	1	0
PDE4D	5144	broad.mit.edu	37	5	58271612	58271612	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:58271612G>A	uc003jsa.2	-	14	2057	c.1885C>T	c.(1885-1887)CAG>TAG	p.Q629*	PDE4D_uc003jrx.2_Nonsense_Mutation_p.Q493*|PDE4D_uc003jry.2_Nonsense_Mutation_p.Q327*|PDE4D_uc003jrz.2_Nonsense_Mutation_p.Q565*|PDE4D_uc003jsb.2_Nonsense_Mutation_p.Q568*|PDE4D_uc003jrt.2_Nonsense_Mutation_p.Q327*|PDE4D_uc003jru.2_Nonsense_Mutation_p.Q405*|PDE4D_uc003jrv.2_Nonsense_Mutation_p.Q499*|PDE4D_uc003jrw.2_Nonsense_Mutation_p.Q507*|PDE4D_uc003jrs.2_Nonsense_Mutation_p.Q338*	NM_001104631	NP_001098101	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 1	629					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	CGGTACAGCTGGAGAGGCTTT	0.493			NA											8	59					0	0	0.004482	0	0
HTR1A	3350	broad.mit.edu	37	5	63256706	63256706	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:63256706C>T	uc011cqt.1	-	1	841	c.841G>A	c.(841-843)GTG>ATG	p.V281M		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	281	Cytoplasmic (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	CCTTGCCTCACCGCGCCATTG	0.652			NA											11	39					0	0	0.000978	0	0
HTR1A	3350	broad.mit.edu	37	5	63256880	63256880	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:63256880G>A	uc011cqt.1	-	1	667	c.667C>T	c.(667-669)CGC>TGC	p.R223C		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	223	Cytoplasmic (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	ATGCGGAAGCGCGCAGCTCGG	0.567			NA											37	86					0	0	0.004289	0	0
HTR1A	3350	broad.mit.edu	37	5	63256927	63256927	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:63256927G>A	uc011cqt.1	-	1	620	c.620C>T	c.(619-621)CCG>CTG	p.P207L		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	207	Helical; Name=5; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GAGCAGCAGCGGGATGTAGAA	0.587			NA											5	186					0	0	0.000602	0	0
TNPO1	3842	broad.mit.edu	37	5	72201204	72201204	+	Silent	SNP	A	A	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:72201204A>G	uc003kck.3	+	24	2811	c.2664A>G	c.(2662-2664)TTA>TTG	p.L888L	TNPO1_uc011csj.1_Silent_p.L838L|TNPO1_uc003kch.2_Silent_p.L880L|TNPO1_uc003kci.3_Silent_p.L880L|TNPO1_uc003kcg.3_Silent_p.L880L	NM_002270	NP_002261	Q92973	TNPO1_HUMAN	transportin 1 isoform 1	888					interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			skin(3)|urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)	7		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		CTCTTCCCTTAAAAGAGCGTC	0.358			NA											21	127					0	0	0.010504	0	0
SERINC5	256987	broad.mit.edu	37	5	79473158	79473158	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:79473158C>A	uc003kgj.2	-	4	565	c.436G>T	c.(436-438)GAT>TAT	p.D146Y	SERINC5_uc003kgk.2_Missense_Mutation_p.D146Y|SERINC5_uc003kgl.2_RNA|SERINC5_uc003kgm.2_Missense_Mutation_p.D146Y|SERINC5_uc011ctj.1_Missense_Mutation_p.D146Y	NM_178276	NP_840060	Q86VE9	SERC5_HUMAN	developmentally regulated protein TPO1	146	Cytoplasmic (Potential).				phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		GTGTCCTGATCTGGAATGAAG	0.403			NA											13	46					2.32078e-09	3.49073e-09	0.003163	1	0
FER	2241	broad.mit.edu	37	5	108516501	108516501	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:108516501G>A	uc003kop.1	+	18	2486	c.2102G>A	c.(2101-2103)AGT>AAT	p.S701N	FER_uc011cvg.1_Missense_Mutation_p.S526N	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	701	Protein kinase.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		CTGAAAATCAGTGACTTTGGA	0.398	Colon(146;1051 1799 9836 27344 47401)		NA											25	88					0	0	0.00333	0	0
DMXL1	1657	broad.mit.edu	37	5	118500202	118500202	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:118500202G>T	uc003ksd.2	+	20	4884	c.4703G>T	c.(4702-4704)GGC>GTC	p.G1568V	DMXL1_uc010jcl.1_Missense_Mutation_p.G1568V	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1568										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		ATTTCTTCAGGCCTGTCTACA	0.333			NA											12	45					6.40141e-05	8.01272e-05	0.000978	1	0
MEGF10	84466	broad.mit.edu	37	5	126769092	126769092	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:126769092G>A	uc003kuh.3	+	15	2093	c.1731G>A	c.(1729-1731)TGG>TGA	p.W577*	MEGF10_uc003kui.3_Nonsense_Mutation_p.W577*	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	577	Extracellular (Potential).|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.|EGF-like 11.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		AGGGACGCTGGGGCCCCAACT	0.577			NA											13	60					0	0	0.001855	0	0
SEPT8	23176	broad.mit.edu	37	5	132097248	132097248	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:132097248G>A	uc003kxr.2	-	7	1102	c.864C>T	c.(862-864)CTC>CTT	p.L288L	SEPT8_uc003kxs.1_Silent_p.L288L|SEPT8_uc003kxu.2_Silent_p.L288L|SEPT8_uc011cxi.1_Silent_p.L286L|SEPT8_uc003kxv.2_Silent_p.L286L|SEPT8_uc003kxt.2_Silent_p.L228L	NM_001098811	NP_001092281	Q92599	SEPT8_HUMAN	septin 8 isoform a	288					cell cycle	septin complex	GTP binding|protein binding			ovary(2)	2		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCTGCTCGCGGAGGTCTTCCA	0.592			NA											8	33					0	0	0.004482	0	0
TGFBI	7045	broad.mit.edu	37	5	135390519	135390519	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:135390519G>A	uc003lbf.3	+	10	1540	c.1379G>A	c.(1378-1380)GGC>GAC	p.G460D	TGFBI_uc003lbg.3_Missense_Mutation_p.G193D|TGFBI_uc003lbh.3_Missense_Mutation_p.G286D|TGFBI_uc011cyb.1_Missense_Mutation_p.G286D|TGFBI_uc010jed.2_Missense_Mutation_p.G193D	NM_000358	NP_000349	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	460	FAS1 3.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(3)|ovary(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ACTCTGGGCGGCAAAAAACTG	0.423			NA											5	223					0	0	0.000602	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167035	140167035	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:140167035G>T	uc003lhb.2	+	1	1160	c.1160G>T	c.(1159-1161)TGC>TTC	p.C387F	PCDHA1_uc003lha.2_Missense_Mutation_p.C387F|PCDHA1_uc003lgz.2_Missense_Mutation_p.C387F	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	387	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGTGACTTGCTCCTTAATG	0.567			NA											24	61					1.37878e-21	2.47638e-21	0.00333	1	0
PCDHA4	56144	broad.mit.edu	37	5	140188946	140188946	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:140188946C>T	uc003lhi.2	+	1	2275	c.2174C>T	c.(2173-2175)GCG>GTG	p.A725V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.A725V|PCDHA4_uc011daa.1_Missense_Mutation_p.A725V	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	725	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGTGCTCTGCGCTGCCCACC	0.662			NA											16	44					0	0	0.00499	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250613	140250613	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:140250613C>G	uc003lia.2	+	1	2783	c.1925C>G	c.(1924-1926)CCG>CGG	p.P642R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.P642R	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	642	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGACTCGCCGCGCCACCGA	0.687			NA											13	29					0	0	0.003163	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515678	140515678	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:140515678C>A	uc003liq.2	+	1	879	c.662C>A	c.(661-663)CCC>CAC	p.P221H		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	221	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGGCTCCGCCCAGGTCCGGG	0.557			NA											18	102					5.3912e-06	7.17845e-06	0.006122	1	0
PCDHB5	26167	broad.mit.edu	37	5	140515852	140515852	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:140515852A>G	uc003liq.2	+	1	1053	c.836A>G	c.(835-837)TAT>TGT	p.Y279C		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	279	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGTGTAGCCTATGCTCTATTC	0.468			NA											49	146					0	0	0.00361	0	0
PCDHB6	56130	broad.mit.edu	37	5	140531098	140531098	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:140531098G>A	uc003lir.2	+	1	1260	c.1260G>A	c.(1258-1260)ACG>ACA	p.T420T	PCDHB6_uc011dah.1_Silent_p.T284T	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	420	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCACTATCACGGTCACTGATT	0.532			NA											9	70					0	0	0.004482	0	0
YIPF5	81555	broad.mit.edu	37	5	143545042	143545042	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:143545042C>A	uc003lnk.3	-	3	678	c.237G>T	c.(235-237)CAG>CAT	p.Q79H	YIPF5_uc003lnl.3_Missense_Mutation_p.Q79H|YIPF5_uc010jgl.2_Missense_Mutation_p.Q25H	NM_001024947	NP_001020118	Q969M3	YIPF5_HUMAN	Yip1 domain family, member 5	79	Cytoplasmic (Potential).|Interaction with Sec23.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi cisterna membrane|integral to membrane				ovary(1)|skin(1)	2		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			CATAGAAAGGCTGAGGTGAAG	0.448			NA											13	81					0.00400662	0.00447152	0.004007	1	0
PPARGC1B	133522	broad.mit.edu	37	5	149216164	149216164	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:149216164G>T	uc003lrc.2	+	8	2188	c.2146G>T	c.(2146-2148)GGG>TGG	p.G716W	PPARGC1B_uc003lrb.1_Missense_Mutation_p.G716W|PPARGC1B_uc003lrd.2_Missense_Mutation_p.G677W|PPARGC1B_uc003lrf.2_Missense_Mutation_p.G695W|PPARGC1B_uc003lre.1_Missense_Mutation_p.G695W	NM_133263	NP_573570	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor	716					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			GGAGCCGTCTGGGGTTCACCT	0.642			NA											10	32					2.17888e-05	2.81406e-05	0.006214	1	0
FAT2	2196	broad.mit.edu	37	5	150945458	150945458	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:150945458G>T	uc003lue.3	-	1	3048	c.3035C>A	c.(3034-3036)ACT>AAT	p.T1012N	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.T1012N	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1012	Extracellular (Potential).|Cadherin 8.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATGGCAGAGAGTCCTGCGGGC	0.607			NA											6	27					5.9392e-07	8.17619e-07	0.001168	1	0
DOCK2	1794	broad.mit.edu	37	5	169129310	169129310	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:169129310A>T	uc003maf.2	+	14	1342	c.1262A>T	c.(1261-1263)GAT>GTT	p.D421V	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_5'Flank|DOCK2_uc010jjl.1_5'UTR	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	421	DHR-1.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCCTCAGGGGATGTCAGGAAC	0.498			NA									OREG0017017	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	76					0	0	0.006214	0	0
FLT4	2324	broad.mit.edu	37	5	180046339	180046339	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr5:180046339G>A	uc003mma.3	-	19	2754	c.2675C>T	c.(2674-2676)GCG>GTG	p.A892V	FLT4_uc003mlz.3_Missense_Mutation_p.A892V	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	892	Cytoplasmic (Potential).|Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CGACATCAGCGCGCGGTGCTC	0.701	Colon(97;1075 1466 27033 27547 35871)		NA							Congenital_Hereditary_Lymphedema				4	16					0	0	0.000602	0	0
KDM1B	221656	broad.mit.edu	37	6	18207730	18207730	+	Silent	SNP	A	A	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:18207730A>G	uc003nco.1	+	9	1227	c.1152A>G	c.(1150-1152)GCA>GCG	p.A384A	KDM1B_uc003ncn.1_Silent_p.A355A	NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	587					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						AAAAACTGGCAGAAGGGCTTG	0.517			NA											14	43					0	0	0.00245	0	0
KIAA0319	9856	broad.mit.edu	37	6	24566863	24566863	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:24566863A>T	uc011djo.1	-	14	2491	c.2254T>A	c.(2254-2256)TAT>AAT	p.Y752N	KIAA0319_uc011djp.1_Missense_Mutation_p.Y707N|KIAA0319_uc003neh.1_Missense_Mutation_p.Y752N|KIAA0319_uc011djq.1_Missense_Mutation_p.Y743N|KIAA0319_uc011djr.1_Missense_Mutation_p.Y752N|KIAA0319_uc010jpt.1_Missense_Mutation_p.Y163N	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	752	PKD 5.|Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						ATCCACAGATAGGACACAATT	0.483			NA											10	108					0	0	0.006214	0	0
ZNF192	7745	broad.mit.edu	37	6	28121316	28121316	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:28121316G>A	uc003nkn.1	+	6	1442	c.1258G>A	c.(1258-1260)GGC>AGC	p.G420S	ZNF192_uc010jqx.1_Missense_Mutation_p.G420S|ZNF192_uc010jqy.1_Missense_Mutation_p.G233S|ZNF192_uc011dkz.1_Missense_Mutation_p.G233S	NM_006298	NP_006289	Q15776	ZN192_HUMAN	zinc finger protein 192	420	C2H2-type 4.				viral reproduction	cytoplasm|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TCAGAGTGCGGGCCTTATTCT	0.493			NA											36	41					0	0	0.003271	0	0
OR2B3	442184	broad.mit.edu	37	6	29054770	29054770	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:29054770C>A	uc003nlx.2	-	1	321	c.256G>T	c.(256-258)GGT>TGT	p.G86C		NM_001005226	NP_001005226			olfactory receptor, family 2, subfamily B,											skin(1)	1						TTGTTGCAACCAATATTTACC	0.448			NA											43	60					2.66277e-13	4.45419e-13	0.006999	1	0
OR2J2	26707	broad.mit.edu	37	6	29142069	29142069	+	Nonsense_Mutation	SNP	T	T	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:29142069T>G	uc011dlm.1	+	1	759	c.657T>G	c.(655-657)TAT>TAG	p.Y219*		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	219	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCACTACCTATGGTGCCATTG	0.458			NA											16	105					0	0	0.00499	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34835154	34835154	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:34835154C>T	uc003oju.3	+	16	3799	c.3565C>T	c.(3565-3567)CCG>TCG	p.P1189S	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	1189										ovary(3)	3						CATCTTTCACCCGGTCAGCAG	0.502			NA											16	114					0	0	0.003163	0	0
PNPLA1	285848	broad.mit.edu	37	6	36269754	36269754	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:36269754C>G	uc010jwf.2	+	6	892	c.892C>G	c.(892-894)CGA>GGA	p.R298G	PNPLA1_uc003olw.1_Missense_Mutation_p.R203G|PNPLA1_uc010jwe.1_Missense_Mutation_p.R212G	NM_001145717	NP_001139189	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	298					lipid catabolic process		hydrolase activity			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4						ACCAAGCCTTCGAGCACGGCA	0.582			NA									OREG0017382	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	36					0	0	0.001168	0	0
TREM2	54209	broad.mit.edu	37	6	41127558	41127558	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:41127558C>A	uc003opy.2	-	3	556	c.454G>T	c.(454-456)GAT>TAT	p.D152Y	TREM2_uc003opz.2_Missense_Mutation_p.D182Y|TREM2_uc010jxl.1_Missense_Mutation_p.D182Y	NM_018965	NP_061838	Q9NZC2	TREM2_HUMAN	triggering receptor expressed on myeloid cells 2	152	Extracellular (Potential).				axon guidance|humoral immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			ovary(1)	1	Ovarian(28;0.0418)|Colorectal(47;0.196)					ACATGGGCATCCTCGAAGCTC	0.627			NA											5	33					3.59834e-05	4.59055e-05	0.001168	1	0
USP49	25862	broad.mit.edu	37	6	41774568	41774568	+	Missense_Mutation	SNP	C	C	T	rs148441118	byFrequency	TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:41774568C>T	uc003ori.2	-	4	376	c.154G>A	c.(154-156)GAC>AAC	p.D52N		NM_018561	NP_061031	Q70CQ1	UBP49_HUMAN	ubiquitin thioesterase 49	52	UBP-type.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0919)|Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000309)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AGGGCGTGGTCCTCAATATAG	0.587			NA											7	97					0	0	0.00308	0	0
SLC22A7	10864	broad.mit.edu	37	6	43267156	43267156	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:43267156T>A	uc003out.2	+	3	527	c.428T>A	c.(427-429)CTG>CAG	p.L143Q	SLC22A7_uc010jyl.1_Missense_Mutation_p.L141Q|SLC22A7_uc003ous.2_Missense_Mutation_p.L141Q	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	143						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			CAGAAAGGTCTGAACAGAGCT	0.582			NA											4	63					0	0	0.000602	0	0
ZNF318	24149	broad.mit.edu	37	6	43322931	43322931	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:43322931T>A	uc003oux.2	-	4	2219	c.2141A>T	c.(2140-2142)AAG>ATG	p.K714M	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	714					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			ATGGTCAGACTTTAGGAATGG	0.512			NA											9	35					0	0	0.006214	0	0
XPO5	57510	broad.mit.edu	37	6	43498531	43498531	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:43498531T>A	uc003ovp.2	-	23	2783	c.2572A>T	c.(2572-2574)ATG>TTG	p.M858L		NM_020750	NP_065801	Q9HAV4	XPO5_HUMAN	exportin 5	858					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			skin(2)|breast(1)|kidney(1)	4	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			TCTTGCTGCATGGAAGGGCCT	0.463			NA											10	44					0	0	0.006214	0	0
MUT	4594	broad.mit.edu	37	6	49412407	49412407	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:49412407C>A	uc003ozg.3	-	9	1876	c.1621G>T	c.(1621-1623)GCT>TCT	p.A541S		NM_000255	NP_000246	P22033	MUTA_HUMAN	methylmalonyl Coenzyme A mutase precursor	541					fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity				0	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CCGCTAGCAGCACATTCGGTT	0.438			NA											25	223					1.04121e-07	1.4637e-07	0.005443	1	0
RHAG	6005	broad.mit.edu	37	6	49582494	49582494	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:49582494C>A	uc003ozk.3	-	5	775	c.713G>T	c.(712-714)AGG>ATG	p.R238M	RHAG_uc010jzl.2_Missense_Mutation_p.R238M|RHAG_uc010jzm.2_Missense_Mutation_p.R238M	NM_000324	NP_000315	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	238	Extracellular (Potential).				carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|skin(1)	2	Lung NSC(77;0.0255)					TACAATGGCCCTGCACTGTTT	0.507	Ovarian(176;476 2003 7720 43408 44749)		NA											11	67					3.07112e-06	4.13441e-06	0.000978	1	0
PKHD1	5314	broad.mit.edu	37	6	51907900	51907900	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:51907900C>A	uc003pah.1	-	27	3130	c.2854G>T	c.(2854-2856)GGA>TGA	p.G952*	PKHD1_uc003pai.2_Nonsense_Mutation_p.G952*	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	952	IPT/TIG 4.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					AAACCAGTTCCGGTAATGTAA	0.353			NA											7	41					8.12818e-05	0.000100707	0.001984	1	0
DST	667	broad.mit.edu	37	6	56373386	56373386	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:56373386C>A	uc003pdf.2	-	69	12851	c.12823G>T	c.(12823-12825)GAC>TAC	p.D4275Y	DST_uc003pcz.3_Missense_Mutation_p.D4097Y|DST_uc011dxj.1_Missense_Mutation_p.D4126Y|DST_uc011dxk.1_Missense_Mutation_p.D4137Y|DST_uc003pcy.3_Missense_Mutation_p.D3771Y	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	6183					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCTTCCAGGTCCCGGATGAAA	0.388			NA											35	105					5.71845e-15	9.81265e-15	0.005524	1	0
COL12A1	1303	broad.mit.edu	37	6	75839938	75839938	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:75839938C>A	uc003phs.2	-	37	6245	c.6079G>T	c.(6079-6081)GGA>TGA	p.G2027*	COL12A1_uc003pht.2_Nonsense_Mutation_p.G863*	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2027	Fibronectin type-III 16.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						TTCCTTGGTCCACTGCGTGGT	0.443			NA											15	39					6.72482e-11	1.05945e-10	0.003163	1	0
ZNF292	23036	broad.mit.edu	37	6	87970078	87970078	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:87970078G>T	uc003plm.3	+	8	6772	c.6731G>T	c.(6730-6732)GGA>GTA	p.G2244V		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	2244					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		CACGGGATTGGACTAAGGGCA	0.418			NA											11	63					0.000673444	0.000783897	0.008291	1	0
C6orf167	253714	broad.mit.edu	37	6	97677061	97677061	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:97677061T>A	uc003ppb.2	-	14	2014	c.1748A>T	c.(1747-1749)CAG>CTG	p.Q583L	C6orf167_uc011eaf.1_Missense_Mutation_p.Q543L	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	583					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		CAGATTTTTCTGGGCATACAT	0.438			NA											10	52					0	0	0.008291	0	0
SOBP	55084	broad.mit.edu	37	6	107955303	107955303	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:107955303G>A	uc003prx.2	+	6	1759	c.1255G>A	c.(1255-1257)GCC>ACC	p.A419T		NM_018013	NP_060483	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog	419	Pro-rich.						metal ion binding			ovary(1)	1		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		TCCGCACCATGCCTCCAACCC	0.692			NA											8	58					0	0	0.004482	0	0
SCML4	256380	broad.mit.edu	37	6	108042097	108042097	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:108042097C>A	uc010kdf.2	-	6	1034	c.783G>T	c.(781-783)TTG>TTT	p.L261F	SCML4_uc003prz.3_Missense_Mutation_p.L203F|SCML4_uc011eam.1_Missense_Mutation_p.L261F|SCML4_uc003pry.3_Missense_Mutation_p.L19F|SCML4_uc003psa.3_Missense_Mutation_p.L232F	NM_198081	NP_932347	Q8N228	SCML4_HUMAN	sex comb on midleg-like 4	261					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		all_cancers(87;3.26e-06)|Acute lymphoblastic leukemia(125;3.08e-08)|all_hematologic(75;1.15e-06)|all_epithelial(87;0.00142)|Colorectal(196;0.0316)		BRCA - Breast invasive adenocarcinoma(108;0.01)|Epithelial(106;0.0509)|all cancers(137;0.0586)|OV - Ovarian serous cystadenocarcinoma(136;0.0758)		AGGAGGGGTGCAAGGAGCCCC	0.622			NA											5	49					0.000602214	0.000706611	0.000602	1	0
SLC22A16	85413	broad.mit.edu	37	6	110746219	110746219	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:110746219G>T	uc003puf.2	-	8	1658	c.1591C>A	c.(1591-1593)CGG>AGG	p.R531R	SLC22A16_uc003pue.2_Silent_p.R512R	NM_033125	NP_149116	Q86VW1	S22AG_HUMAN	solute carrier family 22, member 16	531					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			ovary(1)	1		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		GTTGCTAGCCGTTTCCCAAGG	0.418			NA											19	74					0.000132079	0.000163091	0.008871	1	0
HINT3	135114	broad.mit.edu	37	6	126298798	126298798	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:126298798C>T	uc003qal.3	+	5	788	c.525C>T	c.(523-525)CAC>CAT	p.H175H	HINT3_uc010keu.2_Silent_p.H66H	NM_138571	NP_612638	Q9NQE9	HINT3_HUMAN	histidine triad nucleotide binding protein 3	175						mitochondrion|nucleolus	hydrolase activity				0				UCEC - Uterine corpus endometrioid carcinoma (4;0.153)|GBM - Glioblastoma multiforme(226;0.0321)		AGGCTGATCACTTGATTGAAA	0.299			NA											10	74					0	0	0.006214	0	0
EPB41L2	2037	broad.mit.edu	37	6	131216229	131216229	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:131216229C>A	uc003qch.2	-	9	1449	c.1267G>T	c.(1267-1269)GTG>TTG	p.V423L	EPB41L2_uc003qcg.1_Missense_Mutation_p.V423L|EPB41L2_uc011eby.1_Missense_Mutation_p.V423L|EPB41L2_uc003qci.2_Missense_Mutation_p.V423L|EPB41L2_uc010kfk.2_Missense_Mutation_p.V423L|EPB41L2_uc010kfl.1_Missense_Mutation_p.V423L	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	423	FERM.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TTAGCACACACGCCCAGCTTG	0.403			NA											9	65					0.000673444	0.000783897	0.008291	1	0
EYA4	2070	broad.mit.edu	37	6	133849880	133849880	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:133849880G>T	uc003qec.3	+	20	2315	c.1857G>T	c.(1855-1857)TGG>TGT	p.W619C	EYA4_uc011ecq.1_Missense_Mutation_p.W565C|EYA4_uc011ecr.1_Intron|EYA4_uc003qed.3_Missense_Mutation_p.W619C|EYA4_uc003qee.3_Missense_Mutation_p.W596C|EYA4_uc011ecs.1_Missense_Mutation_p.W625C|uc003qeg.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	619					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		TGCCCTTCTGGAGGATATCCA	0.328	Melanoma(57;398 1237 3528 4702 7415)		NA											23	159					3.28513e-13	5.44541e-13	0.003954	1	0
KIAA1244	57221	broad.mit.edu	37	6	138629992	138629992	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:138629992G>T	uc003qhu.2	+	24	4090	c.4090G>T	c.(4090-4092)GGA>TGA	p.G1364*		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	1364					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		GTTTGTCAAAGGACTGGGTAA	0.473			NA											14	145					1.05317e-09	1.60056e-09	0.00245	1	0
GPR126	57211	broad.mit.edu	37	6	142736158	142736158	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:142736158C>G	uc010khc.2	+	19	3005	c.2594C>G	c.(2593-2595)ACT>AGT	p.T865S	GPR126_uc010khd.2_Missense_Mutation_p.T837S|GPR126_uc010khe.2_Missense_Mutation_p.T865S|GPR126_uc010khf.2_Missense_Mutation_p.T837S	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	865	Helical; Name=1; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		AAAGTCCTCACTTTCATCAGC	0.388			NA											11	54					0	0	0.008291	0	0
UTRN	7402	broad.mit.edu	37	6	144745141	144745141	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:144745141G>T	uc003qkt.2	+	5	424	c.332G>T	c.(331-333)GGG>GTG	p.G111V	UTRN_uc010khq.1_Missense_Mutation_p.G111V	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	111	CH 1.|Actin-binding.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GTGAATATAGGGGGAACTGAC	0.353			NA											16	130					6.94344e-10	1.05964e-09	0.006122	1	0
KATNA1	11104	broad.mit.edu	37	6	149959680	149959680	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:149959680T>C	uc003qmr.1	-	1	49	c.4A>G	c.(4-6)AGT>GGT	p.S2G	KATNA1_uc003qms.2_Missense_Mutation_p.S2G|KATNA1_uc003qmt.2_Missense_Mutation_p.S2G|KATNA1_uc011eed.1_Missense_Mutation_p.S2G	NM_007044	NP_008975	O75449	KTNA1_HUMAN	katanin p60 subunit A 1	2	Interaction with microtubule.|Interaction with KATNB1.				cell division|interphase of mitotic cell cycle|mitosis	microtubule|microtubule organizing center|spindle pole	ATP binding|microtubule binding|microtubule-severing ATPase activity|protein heterodimerization activity			skin(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;2.95e-12)|GBM - Glioblastoma multiforme(68;0.173)		ATAAGAAGACTCATGTTCAAC	0.328			NA											19	115					0	0	0.007413	0	0
SYNE1	23345	broad.mit.edu	37	6	152527394	152527394	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:152527394A>C	uc010kiw.2	-	126	23530	c.22928T>G	c.(22927-22929)TTG>TGG	p.L7643W	SYNE1_uc010kiv.2_Missense_Mutation_p.L2167W|SYNE1_uc003qos.3_Missense_Mutation_p.L2167W|SYNE1_uc003qot.3_Missense_Mutation_p.L7572W|SYNE1_uc003qou.3_Missense_Mutation_p.L7643W|SYNE1_uc003qor.3_Missense_Mutation_p.L543W	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7643	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCGGCCTGCAAGGCGGCCTC	0.507			NA								HNSCC(10;0.0054)			8	40					0	0	0.004482	0	0
SYNE1	23345	broad.mit.edu	37	6	152748945	152748945	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:152748945C>G	uc010kiw.2	-	38	5585	c.4983G>C	c.(4981-4983)GAG>GAC	p.E1661D	SYNE1_uc003qot.3_Missense_Mutation_p.E1668D|SYNE1_uc003qou.3_Missense_Mutation_p.E1661D|SYNE1_uc010kjb.1_Missense_Mutation_p.E1644D|SYNE1_uc003qow.2_Missense_Mutation_p.E956D	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1661	Spectrin 2.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATAGTTCTTTCTCTAGCCTAA	0.418			NA								HNSCC(10;0.0054)			19	59					0	0	0.008871	0	0
LPA	4018	broad.mit.edu	37	6	161012107	161012107	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:161012107T>A	uc003qtl.2	-	24	3776	c.3656A>T	c.(3655-3657)AAT>ATT	p.N1219I		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3727	Kringle 33.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	AGCATCTGGATTCCTGCAGTA	0.453			NA											3	32					0	0	0.000602	0	0
PLG	5340	broad.mit.edu	37	6	161135904	161135904	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:161135904G>T	uc003qtm.3	+	6	689	c.626G>T	c.(625-627)TGG>TTG	p.W209L		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	209	Kringle 2.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	TGCCAGGCCTGGGACTCTCAG	0.473			NA											5	35					0.00116845	0.00134087	0.001168	1	0
THBS2	7058	broad.mit.edu	37	6	169637732	169637732	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:169637732A>C	uc003qwt.2	-	9	1536	c.1288T>G	c.(1288-1290)TGT>GGT	p.C430G		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	430	TSP type-1 1.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CGGGTGTCACACTTGCTCAGA	0.642	Esophageal Squamous(91;219 1934 18562 44706)		NA											5	45					0	0	0.000602	0	0
C7orf26	79034	broad.mit.edu	37	7	6631427	6631427	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:6631427G>T	uc003sqo.1	+	2	343	c.343G>T	c.(343-345)GGA>TGA	p.G115*	C7orf26_uc003sqp.1_Nonsense_Mutation_p.G96*|C7orf26_uc003sqq.1_5'UTR	NM_024067	NP_076972	Q96N11	CG026_HUMAN	hypothetical protein LOC79034	115										ovary(1)	1		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)		GAGCTTGTTGGGAAAACTGGT	0.512			NA											29	155					2.4375e-19	4.31431e-19	0.007291	1	0
ANKMY2	57037	broad.mit.edu	37	7	16666776	16666776	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:16666776C>A	uc003sti.2	-	3	360	c.160G>T	c.(160-162)GCA>TCA	p.A54S	ANKMY2_uc010ktz.2_RNA	NM_020319	NP_064715	Q8IV38	ANKY2_HUMAN	ankyrin repeat and MYND domain containing 2	54	ANK 1.					cilium	zinc ion binding			central_nervous_system(1)	1	Lung NSC(10;0.103)|all_lung(11;0.204)			UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		CCTTTATATGCTGCATGCATT	0.353			NA											10	37					9.16793e-09	1.33768e-08	0.00499	1	0
FERD3L	222894	broad.mit.edu	37	7	19184913	19184913	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:19184913G>T	uc003suo.1	-	1	132	c.73C>A	c.(73-75)CCG>ACG	p.P25T	uc003sun.1_RNA	NM_152898	NP_690862	Q96RJ6	FER3L_HUMAN	nephew of atonal 3	25					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			large_intestine(1)	1						GGGCGTCTCGGGGAGGCCAGG	0.667			NA											7	90					1.06961e-07	1.49787e-07	0.00308	1	0
IGF2BP3	10643	broad.mit.edu	37	7	23383458	23383458	+	Missense_Mutation	SNP	G	G	T	rs149351958		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:23383458G>T	uc003swg.2	-	9	1222	c.956C>A	c.(955-957)ACG>AAG	p.T319K	IGF2BP3_uc003swf.2_Intron	NM_006547	NP_006538	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding	319	KH 2.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			ovary(2)	2						ATTATACAGCGTCAATTCCTG	0.388			NA											27	96					1.77063e-15	3.04549e-15	0.005443	1	0
CPVL	54504	broad.mit.edu	37	7	29111439	29111439	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:29111439G>T	uc003szv.2	-	9	933	c.814C>A	c.(814-816)CAT>AAT	p.H272N	CPVL_uc003szw.2_Missense_Mutation_p.H272N|CPVL_uc003szx.2_Missense_Mutation_p.H272N	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	272					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2						ATGCATTCATGGCACTGCTTC	0.458			NA											55	88					2.01807e-28	3.68802e-28	0.00361	1	0
CCDC129	223075	broad.mit.edu	37	7	31683245	31683245	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:31683245C>A	uc003tcj.1	+	11	3254	c.2261C>A	c.(2260-2262)GCA>GAA	p.A754E	CCDC129_uc011kad.1_Missense_Mutation_p.A764E|CCDC129_uc003tci.1_Missense_Mutation_p.A605E|CCDC129_uc011kae.1_Missense_Mutation_p.A780E|CCDC129_uc003tck.1_Missense_Mutation_p.A662E	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	754											0						GGGACAAAAGCAAGACAGTTA	0.502			NA											8	108					0.00307968	0.00345283	0.00308	1	0
NPSR1	387129	broad.mit.edu	37	7	34888198	34888198	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:34888198G>T	uc003teg.1	+	8	1076	c.948G>T	c.(946-948)CAG>CAT	p.Q316H	AAA1_uc010kwq.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Missense_Mutation_p.Q316H|NPSR1_uc010kwt.1_Missense_Mutation_p.Q163H|NPSR1_uc010kwu.1_Missense_Mutation_p.Q106H|NPSR1_uc010kwv.1_Missense_Mutation_p.Q250H|NPSR1_uc003tei.1_Missense_Mutation_p.Q316H|NPSR1_uc010kww.1_Missense_Mutation_p.Q305H|NPSR1_uc011kar.1_Missense_Mutation_p.Q250H	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	316	Helical; Name=7; (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	TGATCATTCAGAACCTGCCAG	0.493			NA											111	169					2.18537e-64	4.0649e-64	0.00361	1	0
POM121L12	285877	broad.mit.edu	37	7	53103646	53103646	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:53103646C>T	uc003tpz.2	+	1	298	c.282C>T	c.(280-282)TCC>TCT	p.S94S		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	94											0						GGGTGGTCTCCGAGGGCTGGA	0.701			NA											11	25					0	0	0.00245	0	0
EGFR	1956	broad.mit.edu	37	7	55242489	55242489	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:55242489G>T	uc003tqk.2	+	19	2505	c.2259G>T	c.(2257-2259)CCG>CCT	p.P753P	EGFR_uc010kzg.1_Silent_p.P708P|EGFR_uc011kco.1_Silent_p.P700P	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	753	Cytoplasmic (Potential).|Protein kinase.		Missing (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L747_P753>S(166)|p.L747_P753del(21)|p.L747_P753>Q(19)|p.S752_I759del(15)|p.T751_I759>N(8)|p.E746_P753>VS(6)|p.P753S(4)|p.T751_I759>S(3)|p.A750_E758>P(3)|p.A750_K757del(2)|p.A750_E758del(2)|p.E746_P753del(2)|p.T751_I759>NKA(2)|p.E749_E758>QP(2)|p.T751_E758del(2)|p.L747_K754>ST(1)|p.T751_E758>A(1)|p.E746_P753>VQ(1)|p.T751_I759>REA(1)|p.L747_A755del(1)|p.P753_I759del(1)|p.P753F(1)|p.L747_A755>SKS(1)|p.L747_K754>N(1)|p.A750_K754del(1)|p.L747_K754del(1)|p.L747_K754>GC(1)|p.L747_N756>SKDD(1)|p.E749_P753>Q(1)|p.L747_P753>CG(1)|p.S752_V769del(1)|p.P753P(1)|p.R748_P753del(1)|p.E746_P753>LS(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAACATCTCCGAAAGCCAACA	0.493			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			30	56					5.91797e-21	1.05771e-20	0.002445	1	0
CLIP2	7461	broad.mit.edu	37	7	73811540	73811540	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:73811540C>A	uc003uam.2	+	14	3184	c.2857C>A	c.(2857-2859)CTG>ATG	p.L953M	CLIP2_uc003uan.2_Missense_Mutation_p.L918M	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	953	Potential.					microtubule associated complex				skin(3)	3						CATCCGGGGCCTGCGTGAAAA	0.637			NA											8	33					0.000442599	0.000527798	0.006214	1	0
PCLO	27445	broad.mit.edu	37	7	82785355	82785355	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:82785355C>A	uc003uhx.2	-	2	891	c.602G>T	c.(601-603)GGA>GTA	p.G201V	PCLO_uc003uhv.2_Missense_Mutation_p.G201V	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	201	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTCAGGTTTTCCTTGCTCCTT	0.448			NA											6	36					0.00116845	0.00134087	0.001168	1	0
ABCB4	5244	broad.mit.edu	37	7	87074240	87074240	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:87074240A>T	uc003uiv.1	-	10	1133	c.1057T>A	c.(1057-1059)TGT>AGT	p.C353S	ABCB4_uc003uiw.1_Missense_Mutation_p.C353S|ABCB4_uc003uix.1_Missense_Mutation_p.C353S	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	353	Helical; (By similarity).|ABC transmembrane type-1 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GCATCAATACATGGGGCAGCC	0.353			NA											6	17					0	0	0.001168	0	0
AKAP9	10142	broad.mit.edu	37	7	91708554	91708554	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:91708554G>A	uc003ulg.2	+	31	7332	c.7107G>A	c.(7105-7107)AAG>AAA	p.K2369K	AKAP9_uc003ulf.2_Silent_p.K2361K|AKAP9_uc003uli.2_Silent_p.K1992K|AKAP9_uc003ulj.2_Silent_p.K139K	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2381	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TTGGACAGAAGACATCAATGA	0.383			NA	T	BRAF	papillary thyroid								12	86					0	0	0.00245	0	0
SAMD9	54809	broad.mit.edu	37	7	92731109	92731109	+	Silent	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:92731109T>C	uc003umf.2	-	3	4558	c.4302A>G	c.(4300-4302)CTA>CTG	p.L1434L	SAMD9_uc003umg.2_Silent_p.L1434L	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1434						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			AGAGGGAAGCTAGAAAATACG	0.373			NA											24	155					0	0	0.00333	0	0
MUC17	140453	broad.mit.edu	37	7	100676084	100676084	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:100676084C>A	uc003uxp.1	+	3	1440	c.1387C>A	c.(1387-1389)CCA>ACA	p.P463T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	463	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|5.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGCACCACTCCAGTGGCCAG	0.498			NA											47	229					5.73435e-26	1.04015e-25	0.00361	1	0
MUC17	140453	broad.mit.edu	37	7	100684682	100684682	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:100684682A>T	uc003uxp.1	+	3	10038	c.9985A>T	c.(9985-9987)AGC>TGC	p.S3329C	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3329	Extracellular (Potential).|54.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TGACGGTACTAGCATGCCAAC	0.488			NA											36	240					0	0	0.003755	0	0
MUC17	140453	broad.mit.edu	37	7	100684721	100684721	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:100684721C>G	uc003uxp.1	+	3	10077	c.10024C>G	c.(10024-10026)CTA>GTA	p.L3342V	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3342	Extracellular (Potential).|54.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AAGCACTCCACTAACAAATAT	0.493			NA											4	305					0	0	0.009096	0	0
ORC5L	5001	broad.mit.edu	37	7	103767298	103767298	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:103767298C>A	uc003vcb.2	-	14	1416	c.1305G>T	c.(1303-1305)TTG>TTT	p.L435F	ORC5L_uc011klp.1_Missense_Mutation_p.L303F	NM_002553	NP_002544	O43913	ORC5_HUMAN	origin recognition complex subunit 5 isoform 1	435					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	cytoplasm|nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|identical protein binding				0						CTTGTTTTCACAAGAAATCAT	0.393			NA											9	39					2.17888e-05	2.81406e-05	0.006214	1	0
MET	4233	broad.mit.edu	37	7	116339431	116339431	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:116339431G>T	uc003vij.2	+	2	480	c.293G>T	c.(292-294)TGT>TTT	p.C98F	MET_uc010lkh.2_Missense_Mutation_p.C98F|MET_uc011knc.1_Missense_Mutation_p.C98F|MET_uc011knd.1_Missense_Mutation_p.C98F|MET_uc011kne.1_Missense_Mutation_p.C98F|MET_uc011knf.1_Missense_Mutation_p.C98F|MET_uc011kng.1_Missense_Mutation_p.C98F|MET_uc011knh.1_Missense_Mutation_p.C98F|MET_uc011kni.1_Missense_Mutation_p.C98F|MET_uc003vii.1_Missense_Mutation_p.C117F|MET_uc010lkg.2_Missense_Mutation_p.C98F|MET_uc011kmz.1_Missense_Mutation_p.C98F|MET_uc011kna.1_Missense_Mutation_p.C98F|MET_uc011knb.1_Missense_Mutation_p.C98F	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	98	Extracellular (Potential).|Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TGTTTCCCATGTCAGGACTGC	0.438			NA	Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				8	64					0.000157383	0.000192065	0.00308	1	0
ASZ1	136991	broad.mit.edu	37	7	117024854	117024854	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:117024854C>T	uc003vjb.2	-	6	676	c.613G>A	c.(613-615)GGA>AGA	p.G205R	ASZ1_uc011kno.1_Missense_Mutation_p.G205R|ASZ1_uc011knp.1_5'UTR	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	205	ANK 5.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			TTATTAGCTCCAAGTTCAAGC	0.363			NA											28	72					0	0	0.004656	0	0
C7orf58	79974	broad.mit.edu	37	7	120906829	120906829	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:120906829A>G	uc003vjq.3	+	20	3047	c.2600A>G	c.(2599-2601)AAT>AGT	p.N867S		NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	867						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					CTTAATTCCAATCACCTGCAA	0.363			NA											16	117					0	0	0.008871	0	0
HYAL4	23553	broad.mit.edu	37	7	123516883	123516883	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:123516883G>A	uc003vlc.2	+	5	1758	c.1120G>A	c.(1120-1122)GAG>AAG	p.E374K	HYAL4_uc011knz.1_3'UTR	NM_012269	NP_036401	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	374	Extracellular (Potential).				fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			skin(1)	1						CAGAGCTGCTGAGGTATGCAG	0.468			NA											14	106					0	0	0.004007	0	0
GRM8	2918	broad.mit.edu	37	7	126746619	126746619	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:126746619T>A	uc003vlr.2	-	2	969	c.658A>T	c.(658-660)ACA>TCA	p.T220S	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.T220S|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_5'UTR	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	220	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GAAGCCAGTGTCGAAACATAA	0.493			NA								HNSCC(24;0.065)			4	44					0	0	0.000602	0	0
FAM180A	389558	broad.mit.edu	37	7	135418761	135418761	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:135418761C>T	uc003vtd.2	-	3	750	c.484G>A	c.(484-486)GAC>AAC	p.D162N	FAM180A_uc010lmt.2_RNA|FAM180A_uc010lmu.2_Missense_Mutation_p.D162N	NM_205855	NP_995327	Q6UWF9	F180A_HUMAN	hypothetical protein LOC389558 precursor	162						extracellular region				ovary(2)	2						CGCATCAAGTCGTGCCTCAGG	0.612			NA											3	22					0	0	0.004672	0	0
CHRM2	1129	broad.mit.edu	37	7	136700873	136700873	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:136700873G>T	uc003vtf.1	+	4	1884	c.1261G>T	c.(1261-1263)GTG>TTG	p.V421L	CHRM2_uc003vtg.1_Missense_Mutation_p.V421L|CHRM2_uc003vtj.1_Missense_Mutation_p.V421L|CHRM2_uc003vtk.1_Missense_Mutation_p.V421L|CHRM2_uc003vtl.1_Missense_Mutation_p.V421L|CHRM2_uc003vtm.1_Missense_Mutation_p.V421L|CHRM2_uc003vti.1_Missense_Mutation_p.V421L|CHRM2_uc003vto.1_Missense_Mutation_p.V421L|CHRM2_uc003vtn.1_Missense_Mutation_p.V421L|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	421	Extracellular (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	CCCCAACACTGTGTGGACAAT	0.453			NA											40	133					7.66079e-34	1.40704e-33	0.002522	1	0
PRSS1	5644	broad.mit.edu	37	7	142459766	142459766	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:142459766C>A	uc003wak.2	+	3	359	c.342C>A	c.(340-342)TCC>TCA	p.S114S	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_3'UTR|PRSS1_uc003wam.2_Silent_p.S54S	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	114	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			TCAAGCTCTCCTCACGTGCAG	0.557			NA							Hereditary_Pancreatitis				19	127					1.15919e-05	1.51586e-05	0.008871	1	0
EPHB6	2051	broad.mit.edu	37	7	142564038	142564038	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:142564038G>T	uc011kst.1	+	9	2213	c.1426G>T	c.(1426-1428)GCT>TCT	p.A476S	EPHB6_uc011ksu.1_Missense_Mutation_p.A476S|EPHB6_uc003wbs.2_Missense_Mutation_p.A184S|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_Missense_Mutation_p.A184S|EPHB6_uc003wbv.2_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	476	Extracellular (Potential).|Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					CCCTCCTCAGGCTGCAGCCAT	0.592			NA											4	25					2.56e-06	3.46548e-06	0.009096	1	0
TAS2R41	259287	broad.mit.edu	37	7	143175790	143175790	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:143175790C>A	uc003wdc.1	+	1	825	c.825C>A	c.(823-825)TGC>TGA	p.C275*	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	275	Helical; Name=7; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					TCTACCTGTGCATATCTGTCC	0.488			NA											4	70					0.000602214	0.000706611	0.000602	1	0
OR2A5	393046	broad.mit.edu	37	7	143748389	143748389	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:143748389G>C	uc011ktw.1	+	1	895	c.895G>C	c.(895-897)GGT>CGT	p.G299R		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	299	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					AGAGGTCAAGGGTGCCCTGAA	0.498			NA											7	67					0	0	0.00308	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146997243	146997243	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:146997243G>C	uc003weu.1	+	9	1875	c.1359G>C	c.(1357-1359)TTG>TTC	p.L453F		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	453	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GTTCTGGGTTGAATGATGGAC	0.378			NA								HNSCC(39;0.1)			9	95					0	0	0.008291	0	0
CUL1	8454	broad.mit.edu	37	7	148484115	148484115	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:148484115T>G	uc010lpg.2	+	13	1908	c.1382T>G	c.(1381-1383)GTA>GGA	p.V461G	CUL1_uc003wey.2_Missense_Mutation_p.V461G|CUL1_uc003wez.2_Missense_Mutation_p.V351G|CUL1_uc003wfa.2_Missense_Mutation_p.V122G	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	461					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GACAAAGACGTATTTCAGAAG	0.488			NA											13	87					0	0	0.001368	0	0
SSPO	23145	broad.mit.edu	37	7	149483226	149483226	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:149483226C>A	uc010lpk.2	+	23	3294	c.3294C>A	c.(3292-3294)TAC>TAA	p.Y1098*	SSPO_uc010lpl.1_Nonsense_Mutation_p.Y348*	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1098	VWFD 3.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCAAGGTCTACACAGGCCCTG	0.657			NA											3	15					0.00024832	0.000299541	0.009096	1	0
PPP1R3B	79660	broad.mit.edu	37	8	8998956	8998956	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:8998956T>C	uc003wsn.3	-	2	371	c.206A>G	c.(205-207)CAG>CGG	p.Q69R	PPP1R3B_uc003wso.3_Missense_Mutation_p.Q68R	NM_024607	NP_078883	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory (inhibitor)	69					glycogen metabolic process					ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		GGCCAGCCCCTGGTTGTCTGC	0.527			NA											9	60					0	0	0.008291	0	0
RP1L1	94137	broad.mit.edu	37	8	10465553	10465553	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:10465553C>A	uc003wtc.2	-	4	6284	c.6055G>T	c.(6055-6057)GAG>TAG	p.E2019*		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	2019					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CCGTCTGACTCTGGCTGGGCC	0.612			NA											26	151					3.28513e-13	5.44541e-13	0.003954	1	0
GATA4	2626	broad.mit.edu	37	8	11606472	11606472	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:11606472G>T	uc003wuc.2	+	3	1215	c.661G>T	c.(661-663)GGG>TGG	p.G221W	GATA4_uc003wub.1_Missense_Mutation_p.G15W|GATA4_uc011kxc.1_Missense_Mutation_p.G222W	NM_002052	NP_002043	P43694	GATA4_HUMAN	GATA binding protein 4	221	GATA-type 1.				atrial septum primum morphogenesis|atrial septum secundum morphogenesis|blood coagulation|cardiac right ventricle morphogenesis|cell-cell signaling|embryonic foregut morphogenesis|embryonic heart tube anterior/posterior pattern formation|endocardial cushion development|endoderm development|heart looping|intestinal epithelial cell differentiation|male gonad development|positive regulation of angiogenesis|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|response to drug|transcription from RNA polymerase II promoter|ventricular septum development	nucleoplasm	activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(15;0.0839)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.199)		TGTCAACTGTGGGGCTATGTC	0.522			NA											16	55					3.41278e-10	5.2743e-10	0.00499	1	0
ADAM28	10863	broad.mit.edu	37	8	24168942	24168942	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:24168942G>C	uc003xdy.2	+	5	458	c.375G>C	c.(373-375)AGG>AGC	p.R125S	ADAM28_uc003xdx.2_Missense_Mutation_p.R125S|ADAM28_uc011kzz.1_5'UTR|ADAM28_uc011laa.1_RNA	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	125					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		GCACATGTAGGGGTCTAAGGT	0.348	NSCLC(193;488 2149 22258 34798 40734)		NA											5	37					0	0	0.001168	0	0
TEX15	56154	broad.mit.edu	37	8	30701025	30701025	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:30701025T>C	uc003xil.2	-	1	5509	c.5509A>G	c.(5509-5511)AAT>GAT	p.N1837D		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1837										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CCACATACATTGATCAACTTT	0.338			NA											16	64					0	0	0.007413	0	0
DDHD2	23259	broad.mit.edu	37	8	38110569	38110569	+	Silent	SNP	A	A	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:38110569A>G	uc003xlb.2	+	15	2192	c.1815A>G	c.(1813-1815)CCA>CCG	p.P605P	DDHD2_uc003xlc.2_Silent_p.P605P|DDHD2_uc003xld.2_Silent_p.P224P	NM_015214	NP_056029	O94830	DDHD2_HUMAN	DDHD domain containing 2 isoform 1	605	DDHD.				lipid catabolic process	centrosome	hydrolase activity|metal ion binding			large_intestine(1)|ovary(1)	2	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			CCAGAGCTCCATACCCTGCCT	0.473			NA											6	32					0	0	0.001168	0	0
AGPAT6	137964	broad.mit.edu	37	8	41469728	41469728	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:41469728G>C	uc003xnz.2	+	7	1670	c.731G>C	c.(730-732)TGT>TCT	p.C244S		NM_178819	NP_848934	Q86UL3	GPAT4_HUMAN	lysophosphatidic acid acyltransferase zeta	244					acyl-CoA metabolic process|lactation|phosphatidylcholine biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	glycerol-3-phosphate O-acyltransferase activity				0	Ovarian(28;0.00769)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.0131)|Lung NSC(58;0.0363)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	OV - Ovarian serous cystadenocarcinoma(14;0.00126)|Colorectal(10;0.0014)|Lung(22;0.00177)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0147)			GGTGGCATCTGTGTGGCCAAT	0.458			NA											5	151					0	0	0.001168	0	0
SNAI2	6591	broad.mit.edu	37	8	49832731	49832731	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:49832731G>T	uc003xqp.2	-	2	513	c.349C>A	c.(349-351)CTT>ATT	p.L117I		NM_003068	NP_003059	O43623	SNAI2_HUMAN	snail 2	117					canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				GGGTCTGAAAGCTTGGACTGT	0.493			NA											71	225					1.91593e-42	3.55468e-42	0.00361	1	0
PXDNL	137902	broad.mit.edu	37	8	52366151	52366151	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:52366151G>A	uc003xqu.3	-	10	1278	c.1177C>T	c.(1177-1179)CAT>TAT	p.H393Y		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	393	Ig-like C2-type 2.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AATCGACCATGATCCCGTTGT	0.473			NA											11	59					0	0	0.000978	0	0
NPBWR1	2831	broad.mit.edu	37	8	53853210	53853210	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:53853210G>T	uc011ldu.1	+	1	743	c.743G>T	c.(742-744)CGG>CTG	p.R248L		NM_005285	NP_005276	P48145	NPBW1_HUMAN	G protein-coupled receptor 7	248	Cytoplasmic (Potential).				synaptic transmission	plasma membrane	opioid receptor activity|protein binding			ovary(2)|breast(1)	3		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)				GCCAAGAAGCGGGTGACCTTC	0.672			NA											3	16					0.004672	0.00512029	0.004672	1	0
RP1	6101	broad.mit.edu	37	8	55541388	55541388	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:55541388G>T	uc003xsd.1	+	4	5094	c.4946G>T	c.(4945-4947)GGG>GTG	p.G1649V	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1649					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTTTTTCCTGGGTCTACCCGC	0.373	Colon(91;1014 1389 7634 14542 40420)		NA											35	167					2.42023e-17	4.20235e-17	0.003271	1	0
TRPA1	8989	broad.mit.edu	37	8	72948636	72948636	+	Silent	SNP	C	C	A	rs146434598	byFrequency	TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:72948636C>A	uc003xza.2	-	21	2617	c.2442G>T	c.(2440-2442)ACG>ACT	p.T814T	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	814	Helical; Name=3; (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	AAATGATGCCCGTCGTGTAGA	0.353			NA											8	59					0.000157383	0.000192065	0.00308	1	0
KCNB2	9312	broad.mit.edu	37	8	73849102	73849102	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:73849102C>A	uc003xzb.2	+	3	2100	c.1512C>A	c.(1510-1512)TCC>TCA	p.S504S		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	504	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			AAACAAGCTCCAACAAGTCTT	0.562			NA											6	114					0.00307968	0.00345283	0.00308	1	0
HEY1	23462	broad.mit.edu	37	8	80679499	80679499	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:80679499G>A	uc003ybm.2	-	2	320	c.120C>T	c.(118-120)TCC>TCT	p.S40S	HEY1_uc010lzq.2_5'Flank|HEY1_uc003ybl.2_Silent_p.S40S	NM_012258	NP_036390	Q9Y5J3	HEY1_HUMAN	hairy/enhancer-of-split related with YRPW motif	40					angiogenesis|negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|transcription, DNA-dependent	nucleus	DNA binding|protein binding			lung(3)	3	all_lung(9;5.1e-05)		Epithelial(68;0.076)|all cancers(69;0.179)			ATGTAGTTGGGGACATGGAAC	0.408			NA											89	289					0	0	0.00361	0	0
ZNF704	619279	broad.mit.edu	37	8	81577099	81577099	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:81577099C>A	uc003yby.1	-	6	1110	c.878G>T	c.(877-879)CGC>CTC	p.R293L		NM_001033723	NP_001028895	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	293						intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			GGGAGCTGAGCGGCTCAACGG	0.537			NA											5	112					0.000602214	0.000706611	0.000602	1	0
SLC26A7	115111	broad.mit.edu	37	8	92346639	92346639	+	Silent	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:92346639G>A	uc003yex.2	+	7	1037	c.759G>A	c.(757-759)AGG>AGA	p.R253R	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Silent_p.R253R|SLC26A7_uc003yfa.2_Silent_p.R253R	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	253	Extracellular (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			AGTTTAAAAGGAAAATTAAAG	0.363			NA											17	65					0	0	0.00499	0	0
KCNS2	3788	broad.mit.edu	37	8	99440308	99440308	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:99440308C>A	uc003yin.2	+	2	451	c.101C>A	c.(100-102)ACG>AAG	p.T34K		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	34	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			CGCTCGCACACGCTGCTGCGC	0.667	Pancreas(138;844 2489 9202 24627)		NA											13	23					1.15088e-07	1.60552e-07	0.004007	1	0
TM7SF4	81501	broad.mit.edu	37	8	105361289	105361289	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:105361289C>A	uc003ylx.1	+	2	558	c.509C>A	c.(508-510)ACC>AAC	p.T170N		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	170					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TGGAACCAGACCCTGGCAGTC	0.458			NA											21	127					4.26978e-12	6.99822e-12	0.00333	1	0
CSMD3	114788	broad.mit.edu	37	8	113241022	113241022	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:113241022T>G	uc003ynu.2	-	70	11086	c.10927A>C	c.(10927-10929)ATA>CTA	p.I3643L	CSMD3_uc003yns.2_Missense_Mutation_p.I2845L|CSMD3_uc003ynt.2_Missense_Mutation_p.I3603L|CSMD3_uc011lhx.1_Missense_Mutation_p.I3474L	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3643	Helical; (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCTGCAAATATAAGTGCAAAA	0.308			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			23	84					0	0	0.00333	0	0
KLHL38	340359	broad.mit.edu	37	8	124664263	124664263	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:124664263C>A	uc003yqs.1	-	1	928	c.904G>T	c.(904-906)GTC>TTC	p.V302F		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	302	Kelch 1.										0						TACAGTAGGACGTCCCTGGTG	0.552			NA											22	61					4.16121e-05	5.28098e-05	0.00278	1	0
FER1L6	654463	broad.mit.edu	37	8	124975546	124975546	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:124975546G>T	uc003yqw.2	+	3	311	c.105G>T	c.(103-105)CAG>CAT	p.Q35H		NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	35	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AAGCACTGCAGGAGGAGCCTT	0.478			NA											12	92					0.000978159	0.00113497	0.000978	1	0
WISP1	8840	broad.mit.edu	37	8	134225226	134225226	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:134225226G>T	uc003yub.2	+	2	265	c.189G>T	c.(187-189)CCG>CCT	p.P63P	WISP1_uc003yuc.2_Silent_p.P63P|WISP1_uc010meb.2_Intron|WISP1_uc010mec.2_Silent_p.P63P|WISP1_uc010med.2_Intron|WISP1_uc003yud.2_5'Flank	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	63	IGFBP N-terminal.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			CCCGCTGCCCGCTGGGGGTCA	0.632			NA											10	44					6.40141e-05	8.01272e-05	0.000978	1	0
FAM135B	51059	broad.mit.edu	37	8	139163668	139163668	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:139163668G>T	uc003yuy.2	-	13	3221	c.3050C>A	c.(3049-3051)GCA>GAA	p.A1017E	FAM135B_uc003yux.2_Missense_Mutation_p.A918E|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.A579E|FAM135B_uc003yvb.2_Missense_Mutation_p.A579E	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1017										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AAAGGTCTCTGCAGAAGTCAG	0.522			NA								HNSCC(54;0.14)			15	61					2.32078e-09	3.49073e-09	0.003163	1	0
EXOSC4	54512	broad.mit.edu	37	8	145135259	145135259	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:145135259G>A	uc003zau.2	+	3	603	c.493G>A	c.(493-495)GTG>ATG	p.V165M	GPAA1_uc003zav.1_5'Flank|GPAA1_uc003zaw.1_5'Flank|GPAA1_uc003zax.2_5'Flank	NM_019037	NP_061910	Q9NPD3	EXOS4_HUMAN	exosome component 4	165					DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear mRNA surveillance|positive regulation of cell growth	cytosol|exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.48e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGCTGGCTTCGTGGACGGCAC	0.637			NA											7	56					0	0	0.001984	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145773606	145773606	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:145773606C>T	uc003zdt.1	-	6	1419	c.864G>A	c.(862-864)CTG>CTA	p.L288L	ARHGAP39_uc011llk.1_Silent_p.L288L|ARHGAP39_uc003zds.1_Silent_p.L288L	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	288	Pro-rich.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						GCTGGGCCAGCAGCGGGGAGC	0.687			NA											6	21					0	0	0.001984	0	0
IL33	90865	broad.mit.edu	37	9	6252962	6252962	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr9:6252962T>A	uc003zjt.2	+	5	497	c.440T>A	c.(439-441)GTT>GAT	p.V147D	IL33_uc011lmg.1_Intron|IL33_uc011lmh.1_Intron|IL33_uc003zju.1_Missense_Mutation_p.V147D	NM_033439	NP_254274	O95760	IL33_HUMAN	interleukin 33 precursor	147					positive regulation of chemokine secretion|positive regulation of inflammatory response|positive regulation of macrophage activation|positive regulation of transcription from RNA polymerase II promoter	extracellular space	cytokine activity				0		Acute lymphoblastic leukemia(23;0.158)|Prostate(43;0.167)		GBM - Glioblastoma multiforme(50;0.0161)|Lung(218;0.105)		GAGATATATGTTGAAGACTTG	0.269			NA											12	41					0	0	0.001855	0	0
TPD52L3	89882	broad.mit.edu	37	9	6328769	6328769	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr9:6328769G>T	uc003zjw.2	+	1	395	c.174G>T	c.(172-174)GGG>GGT	p.G58G	TPD52L3_uc003zjv.2_Silent_p.G58G|TPD52L3_uc003zjx.1_Silent_p.G58G	NM_033516	NP_277051	Q96J77	TPD55_HUMAN	protein kinase NYD-SP25 isoform 1	58							protein binding				0		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0198)|Lung(218;0.1)		GACGCTGTGGGGAACTCAAGA	0.507			NA											9	42					5.4927e-09	8.11145e-09	0.004482	1	0
BNC2	54796	broad.mit.edu	37	9	16552658	16552658	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr9:16552658T>A	uc003zml.2	-	5	679	c.539A>T	c.(538-540)CAA>CTA	p.Q180L	BNC2_uc011lmw.1_Missense_Mutation_p.Q85L|BNC2_uc003zmm.2_Missense_Mutation_p.Q138L|BNC2_uc003zmq.1_Missense_Mutation_p.Q194L|BNC2_uc003zmr.1_Missense_Mutation_p.Q217L|BNC2_uc003zmp.1_Missense_Mutation_p.Q208L|BNC2_uc010mij.1_Missense_Mutation_p.Q102L|BNC2_uc011lmv.1_Missense_Mutation_p.Q6L|BNC2_uc003zmo.1_Missense_Mutation_p.Q102L	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	180					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		AGGCACTGCTTGTGTCCCATA	0.562			NA											10	45					0	0	0.008291	0	0
IFNA14	3448	broad.mit.edu	37	9	21239471	21239471	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr9:21239471A>G	uc010mis.2	-	1	508	c.464T>C	c.(463-465)ATG>ACG	p.M155T	IFNA14_uc003zoo.1_RNA	NM_002172	NP_002163	P01570	IFN14_HUMAN	interferon, alpha 14 precursor	155					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		TTTCTTCTCCATCAGATAAAG	0.443			NA											8	350					0	0	0.007291	0	0
IFNA14	3448	broad.mit.edu	37	9	21239473	21239473	+	Silent	SNP	C	C	T	rs150969341	byFrequency	TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr9:21239473C>T	uc010mis.2	-	1	506	c.462G>A	c.(460-462)CTG>CTA	p.L154L	IFNA14_uc003zoo.1_RNA	NM_002172	NP_002163	P01570	IFN14_HUMAN	interferon, alpha 14 precursor	154					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		TCTTCTCCATCAGATAAAGAG	0.448			NA											8	355					0	0	0.007291	0	0
FAM75A6	389730	broad.mit.edu	37	9	43625106	43625106	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr9:43625106C>T	uc011lrb.1	-	4	3610	c.3581G>A	c.(3580-3582)TGT>TAT	p.C1194Y		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	1194						integral to membrane					0						GCTGTACACACATGATCTGTT	0.438			NA											18	112					0	0	0.007413	0	0
FOXB2	442425	broad.mit.edu	37	9	79634849	79634849	+	Silent	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr9:79634849C>T	uc004ako.1	+	1	279	c.279C>T	c.(277-279)TGC>TGT	p.C93C		NM_001013735	NP_001013757	Q5VYV0	FOXB2_HUMAN	forkhead box B2	93	Fork-head.				brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						ACCCCGACTGCGGGGACATGT	0.642			NA											6	23					0	0	0.00308	0	0
UBQLN1	29979	broad.mit.edu	37	9	86293365	86293365	+	Silent	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr9:86293365T>A	uc004amv.2	-	5	1435	c.861A>T	c.(859-861)GCA>GCT	p.A287A	UBQLN1_uc004amw.2_Silent_p.A287A	NM_013438	NP_038466	Q9UMX0	UBQL1_HUMAN	ubiquilin 1 isoform 1	287					apoptosis|regulation of protein ubiquitination|response to hypoxia	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm|proteasome complex	kinase binding				0						CCTGCTCTTGTGCAGCACTCA	0.458	Melanoma(186;1284 2073 12755 14558 18426)		NA											25	212					0	0	0.003954	0	0
SECISBP2	79048	broad.mit.edu	37	9	91940394	91940394	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr9:91940394C>T	uc004aqj.1	+	3	315	c.235C>T	c.(235-237)CAG>TAG	p.Q79*	SECISBP2_uc010mqn.1_Nonsense_Mutation_p.Q79*|SECISBP2_uc004aqi.1_Intron|SECISBP2_uc011ltk.1_Nonsense_Mutation_p.Q79*|SECISBP2_uc004aqk.1_Intron|SECISBP2_uc010mqo.1_5'UTR|SECISBP2_uc011ltl.1_Nonsense_Mutation_p.Q11*	NM_024077	NP_076982	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	79					translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3						TTTTCCACCTCAGTATTTATC	0.388			NA											28	136					0	0	0.004656	0	0
TLR4	7099	broad.mit.edu	37	9	120475175	120475175	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr9:120475175C>T	uc004bjz.2	+	3	1060	c.769C>T	c.(769-771)CGT>TGT	p.R257C	TLR4_uc004bka.2_Missense_Mutation_p.R217C|TLR4_uc004bkb.2_Missense_Mutation_p.R57C	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	257	Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						AGAAGTCCATCGTTTGGTTCT	0.343			NA											24	96					0	0	0.00333	0	0
TLR4	7099	broad.mit.edu	37	9	120476002	120476002	+	Missense_Mutation	SNP	C	C	A	rs34953464		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr9:120476002C>A	uc004bjz.2	+	3	1887	c.1596C>A	c.(1594-1596)TTC>TTA	p.F532L	TLR4_uc004bka.2_Missense_Mutation_p.F492L|TLR4_uc004bkb.2_Missense_Mutation_p.F332L	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	532	LRR 17.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						ACAACAACTTCTTTTCATTGG	0.423			NA											8	46					0.000157383	0.000192065	0.00308	1	0
NUP214	8021	broad.mit.edu	37	9	134103703	134103703	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr9:134103703G>T	uc004cag.2	+	33	6170	c.6059G>T	c.(6058-6060)AGC>ATC	p.S2020I	NUP214_uc004cah.2_Missense_Mutation_p.S2010I|NUP214_uc004cai.2_Missense_Mutation_p.S1450I|NUP214_uc010mzg.2_RNA|NUP214_uc011mcg.1_Missense_Mutation_p.S846I	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	2020	Pro/Ser/Thr-rich.|11 X 3 AA approximate repeats.|11 X 5 AA approximate repeats.|18 X 4 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		GCAGCTGCCAGCGCAGGAGGA	0.607	Pancreas(4;24 48 25510 30394 32571)		NA	T	DEK|SET|ABL1	AML|T-ALL								8	38					0.000274275	0.00032922	0.004482	1	0
TMEM8C	389827	broad.mit.edu	37	9	136384029	136384029	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr9:136384029G>T	uc011mdk.1	-	3	366	c.366C>A	c.(364-366)ATC>ATA	p.I122I		NM_001080483	NP_001073952	A6NI61	TMM8C_HUMAN	transmembrane protein 8C	122	Helical; (Potential).					integral to membrane					0						TGGCTGTGCCGATGGGGCCCG	0.612			NA											11	48					5.50884e-06	7.30846e-06	0.001368	1	0
COL5A1	1289	broad.mit.edu	37	9	137630626	137630626	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr9:137630626C>A	uc004cfe.2	+	11	1848	c.1466C>A	c.(1465-1467)ACT>AAT	p.T489N		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	489	Interrupted collagenous region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		ATGGGTCCCACTGGCCAAGTC	0.557			NA											13	55					2.61681e-11	4.18576e-11	0.00245	1	0
ARSF	416	broad.mit.edu	37	X	3002690	3002690	+	Silent	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:3002690G>T	uc004cre.1	+	6	1034	c.813G>T	c.(811-813)GCG>GCT	p.A271A	ARSF_uc004crf.1_Silent_p.A271A	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	271						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGAAGGAAGCGATTTCCTTTT	0.393			NA											9	18					5.16669e-11	8.19273e-11	0.000978	1	0
DMD	1756	broad.mit.edu	37	X	32398634	32398634	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:32398634C>G	uc004dda.1	-	34	5082	c.4838G>C	c.(4837-4839)TGG>TCG	p.W1613S	DMD_uc004dcw.2_Missense_Mutation_p.W269S|DMD_uc004dcx.2_Missense_Mutation_p.W272S|DMD_uc004dcz.2_Missense_Mutation_p.W1490S|DMD_uc004dcy.1_Missense_Mutation_p.W1609S|DMD_uc004ddb.1_Missense_Mutation_p.W1605S|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1613	Spectrin 11.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TACCTTTCCCCAGGCAACTTC	0.358			NA											15	52					0	0	0.003163	0	0
DDX3X	1654	broad.mit.edu	37	X	41203341	41203341	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:41203341C>T	uc004dfe.2	+	9	1679	c.824C>T	c.(823-825)ACG>ATG	p.T275M	DDX3X_uc010nhf.1_Missense_Mutation_p.T259M|DDX3X_uc004dff.2_Missense_Mutation_p.T275M|DDX3X_uc011mkq.1_Missense_Mutation_p.T259M|DDX3X_uc011mkr.1_Missense_Mutation_p.T275M|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA|DDX3X_uc011mkt.1_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	275	Necessary for interaction with XPO1.|Helicase ATP-binding.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						TTAGCACCAACGAGAGAGTTG	0.368			NA								HNSCC(61;0.18)			7	14					0	0	0.00308	0	0
ITIH5L	347365	broad.mit.edu	37	X	54783745	54783745	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:54783745G>T	uc004dtj.2	-	8	2792	c.2762C>A	c.(2761-2763)TCT>TAT	p.S921Y		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	921	Pro-rich.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						TCCAAGGACAGAGGTGGTTGT	0.577			NA											7	20					2.0095e-06	2.73038e-06	0.001984	1	0
USP51	158880	broad.mit.edu	37	X	55513497	55513497	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:55513497C>A	uc004dun.1	-	2	1955	c.1876G>T	c.(1876-1878)GCC>TCC	p.A626S	USP51_uc011moo.1_Missense_Mutation_p.A330S	NM_201286	NP_958443	Q70EK9	UBP51_HUMAN	ubiquitin specific protease 51	626					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						TTAGTAGAGGCCAAAAACGGA	0.433			NA											8	13					0.000442599	0.000527798	0.006214	1	0
MTMR8	55613	broad.mit.edu	37	X	63444307	63444307	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:63444307G>C	uc011mou.1	-	11	2058	c.1990C>G	c.(1990-1992)CGC>GGC	p.R664G	ASB12_uc004dvp.1_Missense_Mutation_p.R280G|ASB12_uc004dvq.1_Missense_Mutation_p.R289G|ASB12_uc004dvr.1_Missense_Mutation_p.R289G	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	Error:Variant_position_missing_in_Q96EF0_after_alignment						nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						AAGGCTCTGCGGACGACTAAA	0.493			NA											4	15					0	0	0.009096	0	0
TEX11	56159	broad.mit.edu	37	X	69828958	69828958	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:69828958T>G	uc004dyl.2	-	23	2069	c.1907A>C	c.(1906-1908)CAG>CCG	p.Q636P	TEX11_uc004dyk.2_Missense_Mutation_p.Q311P|TEX11_uc004dym.2_Missense_Mutation_p.Q621P	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	636							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					TCGAAACCACTGAGCTTCATT	0.289			NA											7	14					0	0	0.004482	0	0
P2RY10	27334	broad.mit.edu	37	X	78216858	78216859	+	Missense_Mutation	DNP	CG	CG	GA			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:78216858_78216859CG>GA	uc004ede.2	+	4	1210_1211	c.841_842CG>GA	c.(841-843)CGA>GAA	p.R281E	P2RY10_uc004edf.2_Missense_Mutation_p.R281E	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	281	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						TCCCGTTGTCCGAATCGCACTG	0.421			NA											26	96					0	0	0.004672	0	0
BRWD3	254065	broad.mit.edu	37	X	80001181	80001181	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:80001181G>T	uc004edt.2	-	7	741	c.478C>A	c.(478-480)CAT>AAT	p.H160N	BRWD3_uc004edo.2_5'UTR|BRWD3_uc004edp.2_5'UTR|BRWD3_uc004edq.2_5'UTR|BRWD3_uc010nmj.1_Intron|BRWD3_uc004edr.2_5'UTR|BRWD3_uc004eds.2_5'UTR|BRWD3_uc004edu.2_5'UTR|BRWD3_uc004edv.2_5'UTR|BRWD3_uc004edw.2_5'UTR|BRWD3_uc004edx.2_5'UTR|BRWD3_uc004edy.2_5'UTR|BRWD3_uc004edz.2_5'UTR|BRWD3_uc004eea.2_5'UTR|BRWD3_uc004eeb.2_Intron	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	160										ovary(4)	4						GGGAAAATATGACCAAAGCGA	0.398			NA											7	27					5.18039e-06	6.91034e-06	0.00308	1	0
CYLC1	1538	broad.mit.edu	37	X	83128653	83128653	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:83128653G>T	uc004eei.1	+	4	958	c.937G>T	c.(937-939)GTT>TTT	p.V313F	CYLC1_uc004eeh.1_Missense_Mutation_p.V312F	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	313	2.				cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						TTCAAAGAAAGTTAAGAAAAA	0.318			NA											3	18					0.00909568	0.00987956	0.009096	1	0
CYLC1	1538	broad.mit.edu	37	X	83129210	83129211	+	Missense_Mutation	DNP	CT	CT	AC			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:83129210_83129211CT>AC	uc004eei.1	+	4	1515_1516	c.1494_1495CT>AC	c.(1492-1497)CACTCA>CAACCA	p.498_499HS>QP	CYLC1_uc004eeh.1_Missense_Mutation_p.497_498HS>QP	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	498_499	7.				cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						ACAAGAAACACTCAAAGGAAAA	0.351			NA											6	6					0	0	0.004672	0	0
PCDH11X	27328	broad.mit.edu	37	X	91133849	91133849	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:91133849G>T	uc004efk.1	+	2	3455	c.2610G>T	c.(2608-2610)AAG>AAT	p.K870N	PCDH11X_uc004efl.1_Missense_Mutation_p.K870N|PCDH11X_uc004efo.1_Missense_Mutation_p.K870N|PCDH11X_uc010nmv.1_Missense_Mutation_p.K870N|PCDH11X_uc004efm.1_Missense_Mutation_p.K870N|PCDH11X_uc004efn.1_Missense_Mutation_p.K870N|PCDH11X_uc004efh.1_Missense_Mutation_p.K870N|PCDH11X_uc004efj.1_Missense_Mutation_p.K870N	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	870	Cytoplasmic (Potential).|Poly-Lys.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						Tgaagaaaaagaaaaagaaga	0.378	NSCLC(38;925 1092 2571 38200 45895)		NA											24	21					1.1804e-14	2.01135e-14	0.003954	1	0
PCDH11X	27328	broad.mit.edu	37	X	91134054	91134054	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:91134054T>C	uc004efk.1	+	2	3660	c.2815T>C	c.(2815-2817)TAC>CAC	p.Y939H	PCDH11X_uc004efl.1_Missense_Mutation_p.Y939H|PCDH11X_uc004efo.1_Missense_Mutation_p.Y939H|PCDH11X_uc010nmv.1_Missense_Mutation_p.Y939H|PCDH11X_uc004efm.1_Missense_Mutation_p.Y939H|PCDH11X_uc004efn.1_Missense_Mutation_p.Y939H|PCDH11X_uc004efh.1_Missense_Mutation_p.Y939H|PCDH11X_uc004efj.1_Missense_Mutation_p.Y939H	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	939	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						GGCCCGACACTACAAATCTGC	0.473	NSCLC(38;925 1092 2571 38200 45895)		NA											49	47					0	0	0.00361	0	0
TCEAL6	158931	broad.mit.edu	37	X	101395808	101395808	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:101395808G>T	uc004eiq.2	-	3	657	c.496C>A	c.(496-498)CAA>AAA	p.Q166K		NM_001006938	NP_001006939	Q6IPX3	TCAL6_HUMAN	transcription elongation factor A (SII)-like 6	166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						ACATCTCTTTGCATCCAATGA	0.512			NA											12	40					4.14922e-12	6.81591e-12	0.004007	1	0
TCEAL3	85012	broad.mit.edu	37	X	102864488	102864488	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:102864488C>A	uc004ekq.2	+	3	758	c.496C>A	c.(496-498)CAA>AAA	p.Q166K	TCEAL3_uc004ekr.2_Missense_Mutation_p.Q166K	NM_001006933	NP_001006934	Q969E4	TCAL3_HUMAN	transcription elongation factor A (SII)-like 3	166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						TCATTGGATGCAAAGAGATGT	0.517			NA											5	121					8.12818e-05	0.000100707	0.001984	1	0
CAPN6	827	broad.mit.edu	37	X	110497517	110497517	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:110497517C>T	uc004epc.1	-	3	448	c.280G>A	c.(280-282)GAG>AAG	p.E94K	CAPN6_uc011msu.1_5'UTR	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	94	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						CAATGAGACTCCTGAACAGCC	0.458			NA											23	62					0	0	0.003954	0	0
RHOXF2B	727940	broad.mit.edu	37	X	119293138	119293138	+	Silent	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:119293138C>A	uc004esl.3	+	2	487	c.297C>A	c.(295-297)GGC>GGA	p.G99G		NM_001099685	NP_001093155	P0C7M4	RHF2B_HUMAN	Rhox homeobox family, member 2B	99						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCACCAGCGGCAGCGATGGCA	0.647			NA											6	16					3.59834e-05	4.59055e-05	0.001168	1	0
ACTRT1	139741	broad.mit.edu	37	X	127185254	127185254	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:127185254T>A	uc004eum.2	-	1	1129	c.932A>T	c.(931-933)GAG>GTG	p.E311V		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	311						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						GAGCCTTTCCTCCAGCCCAGG	0.502			NA											16	42					0	0	0.007413	0	0
SLITRK4	139065	broad.mit.edu	37	X	142716539	142716539	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:142716539C>A	uc004fbx.2	-	2	2762	c.2386G>T	c.(2386-2388)GGT>TGT	p.G796C	SLITRK4_uc004fby.2_Missense_Mutation_p.G796C	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	796	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TGGTTGCCACCTATCAGTGAC	0.413			NA											21	78					2.37509e-13	4.00968e-13	0.010504	1	0
SLITRK2	84631	broad.mit.edu	37	X	144905684	144905684	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:144905684A>T	uc004fcd.2	+	5	2731	c.1741A>T	c.(1741-1743)AGC>TGC	p.S581C	SLITRK2_uc010nsp.2_Missense_Mutation_p.S581C|SLITRK2_uc010nso.2_Missense_Mutation_p.S581C|SLITRK2_uc011mwq.1_Missense_Mutation_p.S581C|SLITRK2_uc011mwr.1_Missense_Mutation_p.S581C|SLITRK2_uc011mws.1_Missense_Mutation_p.S581C|SLITRK2_uc004fcg.2_Missense_Mutation_p.S581C|SLITRK2_uc011mwt.1_Missense_Mutation_p.S581C	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	581	Extracellular (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					CTGTCCAGACAGCCCAAACTT	0.473			NA											8	22					0	0	0.00308	0	0
MAGEA11	4110	broad.mit.edu	37	X	148798362	148798362	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:148798362G>A	uc004fdq.2	+	5	1318	c.1216G>A	c.(1216-1218)GCC>ACC	p.A406T	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Missense_Mutation_p.A377T	NM_005366	NP_005357	P43364	MAGAB_HUMAN	melanoma antigen family A, 11 isoform a	406	MAGE.					cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					CATAGCCAATGCCAATGGGAG	0.557			NA											24	97					0	0	0.004656	0	0
GPR50	9248	broad.mit.edu	37	X	150349228	150349228	+	Silent	SNP	A	A	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:150349228A>G	uc010ntg.1	+	2	1308	c.1173A>G	c.(1171-1173)AGA>AGG	p.R391R	uc004fes.1_5'Flank	NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	391	Cytoplasmic (Potential).|Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CCCATTCCAGATCCTCCTCTG	0.577			NA											15	49					0	0	0.003163	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900601	151900601	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:151900601C>A	uc010ntp.2	-	3	554	c.200G>T	c.(199-201)GGA>GTA	p.G67V	MAGEA12_uc004fgb.2_Intron|MAGEA12_uc004fgc.2_Missense_Mutation_p.G67V|CSAG1_uc004fge.2_5'Flank|CSAG1_uc004fgf.2_5'Flank|CSAG1_uc004fgd.2_5'Flank	NM_005367	NP_005358	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	67										skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GGTGGAGGCTCCCTGAGGACT	0.592			NA											25	42					9.86323e-18	1.72489e-17	0.003954	1	0
MTCP1NB	100272147	broad.mit.edu	37	X	154290188	154290188	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:154290188C>G	uc004fmy.2	-	3	726	c.137G>C	c.(136-138)AGA>ACA	p.R46T		NM_001018024	NP_001018024	P56277	MTCNB_HUMAN	mature T-cell proliferation 1 neighbor	46					cell proliferation	mitochondrion				lung(1)	1						GACGACAGATCTTCCCTTGGG	0.438			NA											3	80					0	0	0.004672	0	0
RERE	473	broad.mit.edu	37	1	8424286	8424286	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:8424286delC	uc001ape.2	-	16	2380	c.1570delG	c.(1570-1572)GAGfs	p.E524fs	RERE_uc001apf.2_Frame_Shift_Del_p.E524fs|RERE_uc010nzx.1_Frame_Shift_Del_p.E256fs|RERE_uc001apd.2_5'UTR	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	524	GATA-type.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		AGGATGTTCTCCCGGCCTCCG	0.592			NA											22	59	---	---	---	---	NA	NA	NA	NA	NA
COL16A1	1307	broad.mit.edu	37	1	32155450	32155450	+	Frame_Shift_Del	DEL	A	A	-			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:32155450delA	uc001btk.1	-	23	1877	c.1512delT	c.(1510-1512)GGTfs	p.G504fs	COL16A1_uc001btj.1_Frame_Shift_Del_p.G333fs|COL16A1_uc001btl.3_Frame_Shift_Del_p.G504fs	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	504	Triple-helical region 9 (COL9) with 3 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		CACAGGGGTCACCCTAGCAGA	0.597	Colon(143;498 1786 21362 25193 36625)		NA											8	42	---	---	---	---	NA	NA	NA	NA	NA
LCE2B	26239	broad.mit.edu	37	1	152659518	152659518	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:152659518delG	uc001fai.2	+	2	253	c.199delG	c.(199-201)GGGfs	p.G67fs		NM_014357	NP_055172	O14633	LCE2B_HUMAN	late cornified envelope 2B	67	Cys-rich.				keratinization					ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGCAACTCTGGGGCTGGTGG	0.672			NA											20	238	---	---	---	---	NA	NA	NA	NA	NA
RNASEL	6041	broad.mit.edu	37	1	182554909	182554909	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:182554909delC	uc001gpj.1	-	1	1200	c.1033delG	c.(1033-1035)GCAfs	p.A345fs	RNASEL_uc009wxz.1_Frame_Shift_Del_p.A345fs|RNASEL_uc001gpk.2_Frame_Shift_Del_p.A345fs|RNASEL_uc009wya.1_Frame_Shift_Del_p.A345fs	NM_021133	NP_066956	Q05823	RN5A_HUMAN	ribonuclease L	345					mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			ovary(4)|stomach(1)	5						TTCAGGGCTGCCCCCCAGTGT	0.453			NA							Hereditary_Prostate_Cancer				7	65	---	---	---	---	NA	NA	NA	NA	NA
PSEN2	5664	broad.mit.edu	37	1	227081775	227081775	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr1:227081775delG	uc009xeo.1	+	12	1567	c.1140delG	c.(1138-1140)ACGfs	p.T380fs	CABC1_uc001hqm.1_5'Flank|PSEN2_uc009xep.1_Frame_Shift_Del_p.T379fs|PSEN2_uc001hqk.2_RNA|uc001hql.1_5'Flank	NM_000447	NP_000438	P49810	PSN2_HUMAN	presenilin 2 isoform 1	380	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|apoptosis|beta-amyloid metabolic process|calcium ion transport|induction of apoptosis by extracellular signals|intracellular signal transduction|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear inner membrane|perinuclear region of cytoplasm|Z disc	aspartic-type endopeptidase activity|protein binding			lung(2)	2		Prostate(94;0.0771)				CGGCTGCCACGGGCAGCGGGG	0.642			NA											12	58	---	---	---	---	NA	NA	NA	NA	NA
TPH1	7166	broad.mit.edu	37	11	18050811	18050811	+	Frame_Shift_Del	DEL	A	A	-			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:18050811delA	uc001mnp.2	-	5	594	c.568delT	c.(568-570)TGCfs	p.C190fs	TPH1_uc009yhe.2_Intron	NM_004179	NP_004170	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	190					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity				0					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	TACTCTCTGCAAGCATGGGTT	0.413			NA											47	370	---	---	---	---	NA	NA	NA	NA	NA
OR10G8	219869	broad.mit.edu	37	11	123900397	123900397	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr11:123900397delC	uc001pzp.1	+	1	68	c.68delC	c.(67-69)GCCfs	p.A23fs		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	23	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		GCGCTGGACGCCCCCCTCTTT	0.592			NA											49	155	---	---	---	---	NA	NA	NA	NA	NA
SYNE2	23224	broad.mit.edu	37	14	64516501	64516501	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr14:64516501delG	uc001xgm.2	+	47	7780	c.7550delG	c.(7549-7551)AGCfs	p.S2517fs	SYNE2_uc001xgl.2_Frame_Shift_Del_p.S2517fs	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2517	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AACAAAGAAAGCCAATATTGT	0.393			NA											7	67	---	---	---	---	NA	NA	NA	NA	NA
KIF2B	84643	broad.mit.edu	37	17	51902186	51902187	+	Frame_Shift_Ins	INS	-	-	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr17:51902186_51902187insT	uc002iua.2	+	1	1948_1949	c.1792_1793insT	c.(1792-1794)GTTfs	p.V598fs	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	598					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						GATTGAAGAGGTTGAAACATTA	0.421			NA											48	103	---	---	---	---	NA	NA	NA	NA	NA
ANO7	50636	broad.mit.edu	37	2	242128053	242128053	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr2:242128053delG	uc002wax.2	+	1	130	c.27delG	c.(25-27)GCGfs	p.A9fs	ANO7_uc002waw.2_Frame_Shift_Del_p.A9fs	NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	9	Cytoplasmic (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						CTGCCTGGGCGGGGCTCCAAG	0.687			NA											24	39	---	---	---	---	NA	NA	NA	NA	NA
CNTN4	152330	broad.mit.edu	37	3	2777972	2777973	+	Frame_Shift_Ins	INS	-	-	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr3:2777972_2777973insA	uc003bpc.2	+	4	350_351	c.129_130insA	c.(127-132)GAGAAAfs	p.E43fs	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Frame_Shift_Ins_p.E43fs	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	43_44	Ig-like C2-type 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		ATTCTGAGGAGAAAAAAGTGAA	0.361			NA											37	157	---	---	---	---	NA	NA	NA	NA	NA
CSN1S1	1446	broad.mit.edu	37	4	70810648	70810648	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:70810648delC	uc003hep.1	+	15	532	c.483delC	c.(481-483)TTCfs	p.F161fs	CSN1S1_uc003heq.1_Frame_Shift_Del_p.F152fs|CSN1S1_uc003her.1_Frame_Shift_Del_p.F153fs	NM_001890	NP_001881	P47710	CASA1_HUMAN	casein alpha s1 isoform 1	161						extracellular region	protein binding|transporter activity				0						ATGTTCCTTTCCCACCGTTTT	0.408			NA											39	261	---	---	---	---	NA	NA	NA	NA	NA
NDST3	9348	broad.mit.edu	37	4	119145679	119145679	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr4:119145679delG	uc003ibx.2	+	7	1976	c.1573delG	c.(1573-1575)GGGfs	p.G525fs	NDST3_uc011cgf.1_Frame_Shift_Del_p.G444fs	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	525	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						GTCCAACTATGGGAATGACCG	0.408			NA											11	158	---	---	---	---	NA	NA	NA	NA	NA
DNAH8	1769	broad.mit.edu	37	6	38820518	38820518	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:38820518delG	uc003ooe.1	+	38	5464	c.4864delG	c.(4864-4866)GCAfs	p.A1622fs		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GACATTTCATGCAAAAGACTA	0.383			NA											30	88	---	---	---	---	NA	NA	NA	NA	NA
MAD2L1BP	9587	broad.mit.edu	37	6	43604373	43604375	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	CTT	CTT	-	-	CTT	CTT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr6:43604373_43604375delCTT	uc003ovv.2	+	2	338_340	c.302_304delCTT	c.(301-306)CCTTCT>CCT	p.S102del	MAD2L1BP_uc003ovu.2_In_Frame_Del_p.S134del	NM_014628	NP_055443	Q15013	MD2BP_HUMAN	MAD2L1 binding protein isoform 2	102					mitotic cell cycle checkpoint|regulation of exit from mitosis	cytoplasm|nucleus|spindle	protein binding				0	all_cancers(18;9.36e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000351)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			TACCGAAAACCTTCTCCCCAGGT	0.483			NA											13	97	---	---	---	---	NA	NA	NA	NA	NA
ZNF479	90827	broad.mit.edu	37	7	57188660	57188661	+	Frame_Shift_Ins	INS	-	-	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:57188660_57188661insT	uc010kzo.2	-	5	732_733	c.461_462insA	c.(460-462)AACfs	p.N154fs		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	154					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			GAAATATTTTGTTTTGGGTAGT	0.292			NA											10	119	---	---	---	---	NA	NA	NA	NA	NA
ZNF735	730291	broad.mit.edu	37	7	63679724	63679724	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr7:63679724delC	uc011kdn.1	+	4	295	c.295delC	c.(295-297)CCAfs	p.P99fs		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	99					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGACCTTCAGCCAGAGCAGAG	0.313			NA											17	229	---	---	---	---	NA	NA	NA	NA	NA
RIMS2	9699	broad.mit.edu	37	8	104987714	104987715	+	Frame_Shift_Ins	INS	-	-	A			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr8:104987714_104987715insA	uc003yls.2	+	14	2482_2483	c.2241_2242insA	c.(2239-2244)CCCAGTfs	p.P747fs	RIMS2_uc003ylp.2_Frame_Shift_Ins_p.P969fs|RIMS2_uc003ylw.2_Frame_Shift_Ins_p.P761fs|RIMS2_uc003ylq.2_Frame_Shift_Ins_p.P761fs|RIMS2_uc003ylr.2_Frame_Shift_Ins_p.P808fs|RIMS2_uc003ylt.2_Frame_Shift_Ins_p.P354fs	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1031_1032					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CATGGTCACCCAGTGTCCCTCC	0.337			NA								HNSCC(12;0.0054)			12	51	---	---	---	---	NA	NA	NA	NA	NA
KLHL4	56062	broad.mit.edu	37	X	86890577	86890578	+	Frame_Shift_Ins	INS	-	-	T			TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chrX:86890577_86890578insT	uc004efb.2	+	9	1909_1910	c.1727_1728insT	c.(1726-1728)GGTfs	p.G576fs	KLHL4_uc004efa.2_Frame_Shift_Ins_p.G576fs	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	576	Kelch 4.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						TATGCTATTGGTGGACGTGATG	0.391			NA											13	18	---	---	---	---	NA	NA	NA	NA	NA
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-50-5933-01A-11D-1753-08	TCGA-50-5933-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cc3a9cfe-8a14-4fb4-a60f-3ec795c5d7a1	90712f33-34db-4346-ab22-59c1a11ebe99	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			6	23	NA	NA	NA	NA	1	1	0.00308	1	1
