Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
USP48	84196	broad.mit.edu	37	1	22033296	22033296	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:22033296G>A	uc001bfb.2	-	16	2267	c.2029C>T	c.(2029-2031)CAG>TAG	p.Q677*	USP48_uc001bfa.2_Nonsense_Mutation_p.Q215*|USP48_uc010odq.1_Nonsense_Mutation_p.Q689*|USP48_uc009vqc.2_Nonsense_Mutation_p.Q611*|USP48_uc001bfc.2_Nonsense_Mutation_p.Q677*|USP48_uc001bfd.1_5'Flank	NM_032236	NP_115612	Q86UV5	UBP48_HUMAN	ubiquitin specific protease 48 isoform a	677	DUSP 2.				ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)	2		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		GGAAAGTACTGCTGCAGTTTG	0.398			NA											11	89					0	0	0.013537	0	0
IQCC	55721	broad.mit.edu	37	1	32672631	32672631	+	Silent	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:32672631C>T	uc001bum.2	+	4	515	c.468C>T	c.(466-468)AGC>AGT	p.S156S	IQCC_uc009vua.2_Silent_p.S236S|IQCC_uc010ogz.1_Silent_p.S56S|DCDC2B_uc001bun.2_5'Flank	NM_018134	NP_060604	Q4KMZ1	IQCC_HUMAN	IQ motif containing C isoform 2	156								p.S156S(1)		ovary(4)	4		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TGCCCCACAGCCAACCTCAGC	0.527			NA											13	99					0	0	0.001855	0	0
STK40	83931	broad.mit.edu	37	1	36826829	36826829	+	Silent	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:36826829G>A	uc001cak.1	-	3	512	c.105C>T	c.(103-105)TTC>TTT	p.F35F	STK40_uc001cal.1_Silent_p.F35F|STK40_uc001cam.1_Silent_p.F35F|STK40_uc009vva.1_Silent_p.F35F|STK40_uc001can.1_Silent_p.F35F	NM_032017	NP_114406	Q8N2I9	STK40_HUMAN	serine/threonine kinase 40	35	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1		Myeloproliferative disorder(586;0.0393)				TACCAAGGATGAATGGTCCAG	0.547			NA											11	81					0	0	0.008291	0	0
SLC44A3	126969	broad.mit.edu	37	1	95357975	95357975	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:95357975G>C	uc001dqv.3	+	14	1866	c.1759G>C	c.(1759-1761)GAA>CAA	p.E587Q	SLC44A3_uc001dqx.3_Missense_Mutation_p.E586Q|SLC44A3_uc010otq.1_Missense_Mutation_p.E519Q|SLC44A3_uc010otr.1_Missense_Mutation_p.E551Q|SLC44A3_uc001dqw.3_Missense_Mutation_p.E539Q|SLC44A3_uc010ots.1_Missense_Mutation_p.E507Q|SLC44A3_uc009wds.2_Missense_Mutation_p.E490Q|SLC44A3_uc010ott.1_Missense_Mutation_p.E506Q	NM_001114106	NP_001107578	Q8N4M1	CTL3_HUMAN	solute carrier family 44, member 3 isoform 1	587						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)	1		all_lung(203;0.000712)|Lung NSC(277;0.00316)		all cancers(265;0.039)|Epithelial(280;0.124)	Choline(DB00122)	ATCTGTGTTTGAAACTGTGCT	0.413			NA											16	123					0	0	0.003163	0	0
GPR61	83873	broad.mit.edu	37	1	110086231	110086231	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:110086231C>T	uc001dxy.2	+	2	1270	c.587C>T	c.(586-588)TCA>TTA	p.S196L		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	196	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		CCAGGCTGTTCACTCCAGTGG	0.577			NA											5	61					0	0	0.000602	0	0
TCHH	7062	broad.mit.edu	37	1	152082861	152082861	+	Silent	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:152082861C>T	uc001ezp.2	-	2	2832	c.2832G>A	c.(2830-2832)CTG>CTA	p.L944L	TCHH_uc009wne.1_Silent_p.L944L	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	944	4-2.|10 X 30 AA tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTTCCTCTCTCAGCAGCTGCT	0.428			NA											15	484					0	0	0.00499	0	0
OR10J3	441911	broad.mit.edu	37	1	159284287	159284287	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:159284287G>A	uc010piu.1	-	1	163	c.163C>T	c.(163-165)CAT>TAT	p.H55Y		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	55	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					GTGTGAAGATGATGGTCCAGG	0.468			NA											13	266					0	0	0.003163	0	0
CDC73	79577	broad.mit.edu	37	1	193218933	193218933	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:193218933A>T	uc001gtb.2	+	16	1734	c.1491A>T	c.(1489-1491)TTA>TTT	p.L497F		NM_024529	NP_078805	Q6P1J9	CDC73_HUMAN	parafibromin	497					cell cycle|histone H2B ubiquitination|histone monoubiquitination|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			parathyroid(46)|ovary(1)|breast(1)|pancreas(1)	49						TAACAGTATTAGAACTCAGCT	0.393			NA							Hyperparathyroidism_Familial_Isolated|Hyperparathyroidism-Jaw_Tumor_Syndrome				11	144					0	0	0.010729	0	0
ASPM	259266	broad.mit.edu	37	1	197111590	197111590	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:197111590C>G	uc001gtu.2	-	3	2049	c.1792G>C	c.(1792-1794)GAA>CAA	p.E598Q	ASPM_uc001gtv.2_Missense_Mutation_p.E598Q|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	598					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						CTTTTGATTTCTCGCACTTCT	0.398			NA											19	385					0	0	0.00278	0	0
FMOD	2331	broad.mit.edu	37	1	203317286	203317286	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:203317286T>A	uc001gzr.2	-	2	249	c.113A>T	c.(112-114)TAC>TTC	p.Y38F	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	38					transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)			GGGATCGTAGTAGGTGGACTG	0.592			NA											9	96					0	0	0.006214	0	0
NFASC	23114	broad.mit.edu	37	1	204923376	204923376	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:204923376G>A	uc001hbj.2	+	6	604	c.276G>A	c.(274-276)ATG>ATA	p.M92I	NFASC_uc001hbh.2_Missense_Mutation_p.M92I|NFASC_uc010pqz.1_Missense_Mutation_p.M86I|NFASC_uc010pra.1_Missense_Mutation_p.M86I|NFASC_uc001hbi.2_Missense_Mutation_p.M86I|NFASC_uc009xbg.1_Missense_Mutation_p.M159I|NFASC_uc010prb.1_Missense_Mutation_p.M86I|NFASC_uc010prc.1_5'UTR	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	92	Ig-like C2-type 1.|Extracellular (Potential).				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GGGTGTCCATGAGGAGGAGGT	0.582			NA											4	101					0	0	0.009096	0	0
IKBKE	9641	broad.mit.edu	37	1	206649522	206649522	+	Splice_Site	SNP	A	A	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:206649522A>G	uc001hdz.1	+	6	727	c.359_splice	c.e6-2	p.V120_splice	IKBKE_uc009xbu.1_Splice_Site_p.V120_splice|IKBKE_uc009xbv.1_Splice_Site_p.V120_splice|IKBKE_uc001hea.1_Splice_Site_p.V35_splice	NM_014002	NP_054721	Q14164	IKKE_HUMAN	IKK-related kinase epsilon						DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			ovary(3)|lung(3)|central_nervous_system(1)|skin(1)	8	Breast(84;0.137)					GTCTGTCCCCAGTGGCCGGCA	0.617			NA											20	18					0	0	0.010504	0	0
LAMB3	3914	broad.mit.edu	37	1	209789861	209789861	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:209789861C>T	uc001hhg.2	-	21	3727	c.3337G>A	c.(3337-3339)GAG>AAG	p.E1113K	LAMB3_uc009xco.2_Missense_Mutation_p.E1113K|LAMB3_uc001hhh.2_Missense_Mutation_p.E1113K	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	1113	Domain I.|Potential.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		AACAGCTCCTCTGCCTCTGTC	0.522			NA											17	261					0	0	0.006122	0	0
RPS6KC1	26750	broad.mit.edu	37	1	213415373	213415373	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:213415373G>A	uc010ptr.1	+	11	2713	c.2554G>A	c.(2554-2556)GAT>AAT	p.D852N	RPS6KC1_uc001hkd.2_Missense_Mutation_p.D840N|RPS6KC1_uc010pts.1_Missense_Mutation_p.D640N|RPS6KC1_uc010ptt.1_Missense_Mutation_p.D640N|RPS6KC1_uc010ptu.1_Missense_Mutation_p.D671N|RPS6KC1_uc010ptv.1_Missense_Mutation_p.D387N|RPS6KC1_uc001hke.2_Missense_Mutation_p.D671N	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	852	Protein kinase 2.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		TCAGACTGATGATTTGGCTAA	0.383			NA											12	299					0	0	0.003163	0	0
SMYD2	56950	broad.mit.edu	37	1	214510074	214510074	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:214510074G>A	uc010ptx.1	+	12	1282	c.1249G>A	c.(1249-1251)GGC>AGC	p.G417S	SMYD2_uc009xdl.1_RNA	NM_020197	NP_064582	Q9NRG4	SMYD2_HUMAN	SET and MYND domain containing 2	417					negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	cytosol|nucleus	histone methyltransferase activity (H3-K36 specific)|p53 binding|RNA polymerase II core binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0122)|all cancers(67;0.0209)|GBM - Glioblastoma multiforme(131;0.106)|Epithelial(68;0.144)		AGTAGCTCACGGCAAAGATCA	0.403			NA											13	145					0	0	0.003163	0	0
CENPF	1063	broad.mit.edu	37	1	214813604	214813604	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:214813604G>C	uc001hkm.2	+	12	2097	c.1923G>C	c.(1921-1923)CAG>CAC	p.Q641H		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	641	Potential.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AAAACTTGCAGAGTAAAATTA	0.338	Colon(80;575 1284 11000 14801 43496)		NA											5	91					0	0	0.000602	0	0
RRP15	51018	broad.mit.edu	37	1	218504419	218504419	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:218504419G>A	uc001hlj.2	+	5	865	c.835G>A	c.(835-837)GAC>AAC	p.D279N	RRP15_uc001hlk.2_RNA	NM_016052	NP_057136	Q9Y3B9	RRP15_HUMAN	ribosomal RNA processing 15 homolog	279						mitochondrion|nucleolus	protein binding				0				all cancers(67;0.0315)|OV - Ovarian serous cystadenocarcinoma(81;0.0411)|GBM - Glioblastoma multiforme(131;0.06)|Epithelial(68;0.248)		ATCTGCAAGTGACTCTGATAC	0.393			NA											5	91					0	0	0.001168	0	0
ZNF678	339500	broad.mit.edu	37	1	227843344	227843344	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:227843344G>A	uc001hqw.1	+	4	1738	c.1393G>A	c.(1393-1395)GAA>AAA	p.E465K	ZNF678_uc009xet.1_Intron|ZNF678_uc009xeu.1_Intron	NM_178549	NP_848644	F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	520					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			pancreas(1)	1		Prostate(94;0.0885)				CAAATGTGAAGAATGTGGCAA	0.363			NA											6	66					0	0	0.001984	0	0
OR2W5	441932	broad.mit.edu	37	1	247655031	247655031	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:247655031G>T	uc001icz.1	+	1	602	c.602G>T	c.(601-603)TGC>TTC	p.C201F		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	201					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			ATTCACCTTTGCCCTGGGGGT	0.592			NA											9	259					4.68919e-08	5.44871e-08	0.008291	1	0
OR2T34	127068	broad.mit.edu	37	1	248737470	248737470	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:248737470C>T	uc001iep.1	-	1	589	c.589G>A	c.(589-591)GTC>ATC	p.V197I		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	197	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TAGAGGGAGACGTCAGAGCAG	0.517			NA											7	246					0	0	0.004482	0	0
PGBD2	267002	broad.mit.edu	37	1	249211155	249211155	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr1:249211155G>C	uc001ifh.2	+	3	519	c.372G>C	c.(370-372)TGG>TGC	p.W124C	PGBD2_uc001ifg.2_Intron|PGBD2_uc009xhd.2_Missense_Mutation_p.W121C	NM_170725	NP_733843	Q6P3X8	PGBD2_HUMAN	hypothetical protein LOC267002 isoform a	124										ovary(1)	1	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TTGGCAGTTGGACTGCATCAG	0.458			NA											6	123					0	0	0.001168	0	0
ACBD5	91452	broad.mit.edu	37	10	27506908	27506908	+	Splice_Site	SNP	C	C	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr10:27506908C>A	uc010qdp.1	-	7	1020	c.829_splice	c.e7+1	p.D277_splice	ACBD5_uc010qdm.1_Splice_Site_p.D275_splice|ACBD5_uc010qdn.1_Splice_Site_p.D168_splice|ACBD5_uc010qdo.1_Intron|ACBD5_uc001ito.2_Splice_Site_p.D242_splice|ACBD5_uc001itp.2_Splice_Site_p.D168_splice|ACBD5_uc001itq.2_Splice_Site_p.D168_splice|ACBD5_uc001itr.1_Splice_Site_p.D66_splice	NM_145698	NP_663736	Q5T8D3	ACBD5_HUMAN	acyl-Coenzyme A binding domain containing 5						transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding				0						GGGGACAATACCTTGGTGAAT	0.373			NA											4	90					0.00909568	0.00955915	0.009096	1	0
EPC1	80314	broad.mit.edu	37	10	32561036	32561036	+	Silent	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr10:32561036C>T	uc001iwg.1	-	13	2262	c.1992G>A	c.(1990-1992)GTG>GTA	p.V664V	EPC1_uc001iwi.3_Silent_p.V591V|EPC1_uc001iwh.1_Silent_p.V641V	NM_025209	NP_079485	Q9H2F5	EPC1_HUMAN	enhancer of polycomb 1	664					histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				ovary(3)|central_nervous_system(1)	4		Prostate(175;0.0199)				GTTCTGATGTCACCAAAGCAG	0.398			NA											10	64					0	0	0.008291	0	0
NRG3	10718	broad.mit.edu	37	10	84744853	84744853	+	Splice_Site	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr10:84744853G>C	uc001kco.2	+	9	1611	c.1584_splice	c.e9-1	p.G528_splice	NRG3_uc010qlz.1_Splice_Site_p.G527_splice|NRG3_uc001kcp.2_Splice_Site_p.K331_splice|NRG3_uc001kcq.2_Splice_Site_p.G178_splice|NRG3_uc001kcr.2_Splice_Site_p.K202_splice	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1						regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		TTCTTTTTCAGGTATTCATCC	0.274			NA											47	220					0	0	0.01441	0	0
COL17A1	1308	broad.mit.edu	37	10	105798252	105798252	+	Silent	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr10:105798252C>T	uc001kxr.2	-	45	3151	c.2982G>A	c.(2980-2982)CCG>CCA	p.P994P		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	994	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GGGGCCCTGGCGGGCCTGACA	0.602			NA											4	153					0	0	0.009096	0	0
ATHL1	80162	broad.mit.edu	37	11	293450	293450	+	Silent	SNP	A	A	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr11:293450A>G	uc010qvu.1	+	9	1543	c.1428A>G	c.(1426-1428)GTA>GTG	p.V476V	ATHL1_uc001lor.3_Intron|ATHL1_uc001los.1_Silent_p.V503V|ATHL1_uc001lou.3_Silent_p.V51V|ATHL1_uc001lov.3_5'Flank	NM_025092	NP_079368	Q32M88	ATHL1_HUMAN	ATH1, acid trehalase-like 1	476					carbohydrate metabolic process		hydrolase activity, acting on glycosyl bonds			liver(1)|central_nervous_system(1)|skin(1)	3		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.38e-28)|Epithelial(43;3.25e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		AGATCAAGGTACCCTTTGACG	0.632			NA											3	35					0	0	0.004672	0	0
NUP98	4928	broad.mit.edu	37	11	3714470	3714470	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr11:3714470C>T	uc001lyh.2	-	27	4594	c.4303G>A	c.(4303-4305)GCA>ACA	p.A1435T	NUP98_uc001lyi.2_Missense_Mutation_p.A1435T|NUP98_uc001lyg.2_Missense_Mutation_p.A400T	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	1452					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		ACCTGAAATGCTTCTTCATAC	0.458			NA	T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								17	175					0	0	0.008871	0	0
OR56A3	390083	broad.mit.edu	37	11	5969263	5969263	+	Silent	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr11:5969263G>C	uc010qzt.1	+	1	687	c.687G>C	c.(685-687)GTG>GTC	p.V229V		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCGAGCTGTGCTGAGACTCA	0.512			NA											3	162					0	0	0.009096	0	0
PDE3B	5140	broad.mit.edu	37	11	14880641	14880641	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr11:14880641C>T	uc001mln.2	+	13	2926	c.2573C>T	c.(2572-2574)GCT>GTT	p.A858V	PDE3B_uc010rcr.1_Missense_Mutation_p.A807V	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	858	Catalytic (By similarity).				cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						GCTGCGTCAGCTTGGAATCTA	0.358			NA											15	113					0	0	0.008871	0	0
OR5J2	282775	broad.mit.edu	37	11	55944458	55944458	+	Missense_Mutation	SNP	G	G	A	rs151315491		TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr11:55944458G>A	uc010rjb.1	+	1	365	c.365G>A	c.(364-366)CGC>CAC	p.R122H		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					GCCTATGACCGCTATGTGGCC	0.453			NA											17	76					0	0	0.00499	0	0
SCGB1D1	10648	broad.mit.edu	37	11	61957768	61957768	+	Silent	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr11:61957768G>A	uc001nsz.1	+	1	59	c.12G>A	c.(10-12)TCG>TCA	p.S4S		NM_006552	NP_006543	O95968	SG1D1_HUMAN	lipophilin A precursor	4						extracellular space	binding			skin(1)	1						TGAGGCTGTCGGTGTGTCTCC	0.587			NA											3	34					0	0	0.004672	0	0
AHNAK	79026	broad.mit.edu	37	11	62284242	62284242	+	Silent	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr11:62284242G>A	uc001ntl.2	-	5	17947	c.17647C>T	c.(17647-17649)CTG>TTG	p.L5883L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5883					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GAAACTGACAGCTCCACCTCG	0.468			NA											45	180					0	0	0.01441	0	0
SIK2	23235	broad.mit.edu	37	11	111590634	111590634	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr11:111590634C>T	uc001plt.2	+	10	1520	c.1402C>T	c.(1402-1404)CAT>TAT	p.H468Y		NM_015191	NP_056006	Q9H0K1	SIK2_HUMAN	SNF1-like kinase 2	468					intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|skin(1)	3						AGACCCCGCTCATGCCTTTGA	0.592			NA											7	45					0	0	0.001984	0	0
RBM7	10179	broad.mit.edu	37	11	114272522	114272522	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr11:114272522A>G	uc001pov.2	+	2	209	c.199A>G	c.(199-201)ATG>GTG	p.M67V	C11orf71_uc001pot.1_5'Flank|C11orf71_uc001pou.3_5'Flank|RBM7_uc001pow.2_Missense_Mutation_p.M67V|RBM7_uc001pox.2_5'UTR	NM_016090	NP_057174	Q9Y580	RBM7_HUMAN	RNA binding motif protein 7	67	RRM.				meiosis		nucleotide binding|protein binding|RNA binding			ovary(2)	2		all_cancers(61;5.06e-12)|all_epithelial(67;5.3e-06)|all_hematologic(158;7.68e-05)|Acute lymphoblastic leukemia(157;0.000966)|Melanoma(852;0.00153)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.0818)|Prostate(24;0.104)		BRCA - Breast invasive adenocarcinoma(274;2.56e-06)|Epithelial(105;4.17e-05)|all cancers(92;0.000348)		TCCTTATGCAATGAATCTACT	0.383			NA											8	80					0	0	0.00308	0	0
OAF	220323	broad.mit.edu	37	11	120096462	120096462	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr11:120096462C>A	uc001pxb.2	+	2	565	c.324C>A	c.(322-324)CAC>CAA	p.H108Q		NM_178507	NP_848602	Q86UD1	OAF_HUMAN	OAF homolog precursor	108											0		Breast(109;0.00663)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)		AGCTGCAGCACAATGAGATCA	0.637			NA											8	130					0.00307968	0.00334307	0.00308	1	0
WNK1	65125	broad.mit.edu	37	12	970206	970206	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr12:970206G>C	uc001qio.3	+	7	2155	c.1648G>C	c.(1648-1650)GAT>CAT	p.D550H	WNK1_uc001qip.3_Missense_Mutation_p.D550H|WNK1_uc001qir.3_5'UTR	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	550					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CTGTGAAGGTGATCACAAGAC	0.438	Colon(19;451 567 6672 12618 28860)		NA											21	293					0	0	0.00333	0	0
CLSTN3	9746	broad.mit.edu	37	12	7295905	7295905	+	Silent	SNP	C	C	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr12:7295905C>A	uc001qsr.2	+	12	2123	c.1845C>A	c.(1843-1845)GTC>GTA	p.V615V	CLSTN3_uc001qss.2_Silent_p.V627V	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	615	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						CCACTGCTGTCAAGTGAGTGT	0.413			NA											5	24					0.000602214	0.000666882	0.000602	1	0
PRB4	5545	broad.mit.edu	37	12	11461564	11461564	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr12:11461564C>T	uc001qzf.1	-	3	387	c.353G>A	c.(352-354)GGA>GAA	p.G118E	PRB4_uc001qzt.2_Missense_Mutation_p.G118E	NM_002723	NP_002714	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	181	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.|7.		Missing (in allele S).			extracellular region				ovary(1)	1						TTCTGGCTTTCCTGGAGGAGG	0.607			NA								HNSCC(22;0.051)			29	253					0	0	0.01441	0	0
PRB4	5545	broad.mit.edu	37	12	11461628	11461628	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr12:11461628C>T	uc001qzf.1	-	3	323	c.289G>A	c.(289-291)GGA>AGA	p.G97R	PRB4_uc001qzt.2_Missense_Mutation_p.G97R	NM_002723	NP_002714	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	118	4.|9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.		Missing (in allele M and allele S).			extracellular region				ovary(1)	1						TCTGGCTTTCCTGGATGAGGT	0.602			NA								HNSCC(22;0.051)			85	378					0	0	0.01441	0	0
PRB4	5545	broad.mit.edu	37	12	11461690	11461690	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr12:11461690C>T	uc001qzf.1	-	3	261	c.227G>A	c.(226-228)GGA>GAA	p.G76E	PRB4_uc001qzt.2_Missense_Mutation_p.G76E	NM_002723	NP_002714	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	76	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.|2.			Missing (in Ref. 7; CAA30542).		extracellular region				ovary(1)	1						TTCTGGCTTTCCTGGAGGAGG	0.617			NA								HNSCC(22;0.051)			36	342					0	0	0.010771	0	0
IGF1	3479	broad.mit.edu	37	12	102811743	102811743	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr12:102811743C>G	uc001tjp.3	-	4	660	c.441G>C	c.(439-441)CAG>CAC	p.Q147H	IGF1_uc001tjn.2_Intron|IGF1_uc001tjm.2_Missense_Mutation_p.Q147H|IGF1_uc001tjo.2_Intron	NM_001111285	NP_001104755	P05019	IGF1_HUMAN	insulin-like growth factor 1 isoform 3	147					anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding			central_nervous_system(1)|pancreas(1)	2						CTTTCCTTCTCTGAGACTTCG	0.468			NA											20	229					0	0	0.007413	0	0
NOS1	4842	broad.mit.edu	37	12	117723102	117723102	+	Silent	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr12:117723102C>T	uc001twm.1	-	7	2012	c.1326G>A	c.(1324-1326)GGG>GGA	p.G442G		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	442					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	AGTTGAACATCCCGTGGGCCG	0.572	Esophageal Squamous(162;1748 2599 51982 52956)		NA											3	33					0	0	0.004672	0	0
MYO16	23026	broad.mit.edu	37	13	109610094	109610094	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr13:109610094G>A	uc001vqt.1	+	17	2044	c.1918G>A	c.(1918-1920)GAG>AAG	p.E640K	MYO16_uc010agk.1_Missense_Mutation_p.E662K|MYO16_uc001vqu.1_Missense_Mutation_p.E440K|MYO16_uc010tjh.1_Missense_Mutation_p.E152K	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	640	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TCTGAACAGGGAGAAATTGGC	0.458			NA											6	23					0	0	0.00308	0	0
MYH6	4624	broad.mit.edu	37	14	23861783	23861783	+	Silent	SNP	C	C	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr14:23861783C>G	uc001wjv.2	-	25	3397	c.3330G>C	c.(3328-3330)CTG>CTC	p.L1110L		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	1110	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GGTTTTCCTTCAGTTTCTTCT	0.488			NA											19	202					0	0	0.010504	0	0
BAZ1A	11177	broad.mit.edu	37	14	35227951	35227951	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr14:35227951C>T	uc001wsk.2	-	25	4913	c.4345G>A	c.(4345-4347)GAT>AAT	p.D1449N	BAZ1A_uc001wsl.2_Missense_Mutation_p.D1417N	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1449	Bromo.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		CAGCTGTCATCATGTCGTACC	0.408			NA											7	122					0	0	0.00308	0	0
LRFN5	145581	broad.mit.edu	37	14	42360699	42360699	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr14:42360699C>G	uc001wvm.2	+	4	2830	c.1632C>G	c.(1630-1632)TTC>TTG	p.F544L	LRFN5_uc010ana.2_Intron	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	544	Helical; (Potential).			F -> L (in Ref. 1; BAG53340).		integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TGCTGGTATTCATCATTATTC	0.403			NA								HNSCC(30;0.082)			11	275					0	0	0.010729	0	0
ZFP36L1	677	broad.mit.edu	37	14	69259641	69259641	+	Silent	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr14:69259641G>C	uc001xkh.1	-	1	145	c.15C>G	c.(13-15)CTC>CTG	p.L5L	ZFP36L1_uc001xki.1_Silent_p.L5L	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	5					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		TGGCAGACACGAGGGTGGTGG	0.557			NA											5	125					0	0	0.000602	0	0
SLC39A9	55334	broad.mit.edu	37	14	69908920	69908920	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr14:69908920C>G	uc001xle.2	+	3	1020	c.340C>G	c.(340-342)CTG>GTG	p.L114V	SLC39A9_uc010aqx.2_Missense_Mutation_p.L114V|SLC39A9_uc001xlf.3_Missense_Mutation_p.L114V|SLC39A9_uc001xlg.3_RNA	NM_018375	NP_060845	Q9NUM3	S39A9_HUMAN	solute carrier family 39 (zinc transporter),	114	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity				0				all cancers(60;0.00299)|BRCA - Breast invasive adenocarcinoma(234;0.0145)|OV - Ovarian serous cystadenocarcinoma(108;0.0373)		TTCCCTCGTTCTGGGCTTCGT	0.493			NA											9	152					0	0	0.008291	0	0
ASB2	51676	broad.mit.edu	37	14	94413798	94413798	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr14:94413798C>G	uc001ycc.1	-	5	1294	c.805G>C	c.(805-807)GAG>CAG	p.E269Q	ASB2_uc001ycd.2_Missense_Mutation_p.E317Q|ASB2_uc001yce.1_Missense_Mutation_p.E215Q	NM_016150	NP_057234	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box-containing protein	269	ANK 7.				intracellular signal transduction					ovary(1)|pancreas(1)	2		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		ACCACCTCCTCATGCTCATTC	0.587			NA											6	64					0	0	0.001984	0	0
TCF12	6938	broad.mit.edu	37	15	57383997	57383997	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr15:57383997A>G	uc002aec.2	+	5	517	c.233A>G	c.(232-234)GAC>GGC	p.D78G	TCF12_uc010ugm.1_Missense_Mutation_p.D130G|TCF12_uc010ugn.1_Missense_Mutation_p.D74G|TCF12_uc002aea.2_Missense_Mutation_p.D78G|TCF12_uc010bfs.2_Intron|TCF12_uc002aeb.2_Missense_Mutation_p.D78G|TCF12_uc002aed.2_Missense_Mutation_p.D78G	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b	78					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		GGTTTTACAGACAGCCCTCAT	0.413			NA	T	TEC	extraskeletal myxoid chondrosarcoma								6	67					0	0	0.001984	0	0
SV2B	9899	broad.mit.edu	37	15	91810797	91810797	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr15:91810797G>T	uc002bqv.2	+	7	1523	c.1132G>T	c.(1132-1134)GCC>TCC	p.A378S	SV2B_uc002bqt.2_Missense_Mutation_p.A378S|SV2B_uc010uqv.1_Missense_Mutation_p.A227S|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	378	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			CTGGGATAATGCCCTGTACTG	0.423			NA											3	21					0.00024832	0.000276843	0.009096	1	0
TMC7	79905	broad.mit.edu	37	16	19056263	19056263	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr16:19056263G>C	uc002dfq.2	+	10	1525	c.1395G>C	c.(1393-1395)AAG>AAC	p.K465N	TMC7_uc010vao.1_3'UTR|TMC7_uc002dfp.2_Missense_Mutation_p.K465N|TMC7_uc010vap.1_Missense_Mutation_p.K355N	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a	465	Cytoplasmic (Potential).					integral to membrane				skin(2)|ovary(1)	3						TGGGCTCCAAGATCACATCCT	0.577			NA											9	132					0	0	0.006214	0	0
RRN3P1	730092	broad.mit.edu	37	16	21817457	21817457	+	Silent	SNP	G	G	A	rs150520281	by1000genomes	TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr16:21817457G>A	uc010vbl.1	-	7	603	c.106C>T	c.(106-108)CTG>TTG	p.L36L	uc002diq.3_Intron	NR_003370				SubName: Full=Putative uncharacterized protein ENSP00000219758;												0						CTTACATCCAGCTTGAGTAGT	0.254			NA											3	25					0	0	0.000602	0	0
CD2BP2	10421	broad.mit.edu	37	16	30364598	30364598	+	Silent	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr16:30364598C>T	uc002dxr.2	-	5	1072	c.819G>A	c.(817-819)TCG>TCA	p.S273S	CD2BP2_uc002dxs.2_Silent_p.S273S	NM_006110	NP_006101	O95400	CD2B2_HUMAN	CD2 antigen (cytoplasmic tail) binding protein	273					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			ovary(1)	1						CATCTCCCCGCGACTCTGCTT	0.567			NA											11	70					0	0	0.008291	0	0
FBRS	64319	broad.mit.edu	37	16	30676242	30676242	+	Splice_Site	SNP	G	G	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr16:30676242G>T	uc002dzd.3	+	2	266	c.3_splice	c.e2+1	p.M1_splice	FBRS_uc002dzc.3_Intron	NM_001105079	NP_001098549	Q9HAH7	FBRS_HUMAN	fibrosin											ovary(1)	1			Colorectal(24;0.103)			CCCCCACATGGTGAGCTCCTC	0.507			NA											4	11					0.00909568	0.00955915	0.009096	1	0
CNOT1	23019	broad.mit.edu	37	16	58555102	58555102	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr16:58555102G>A	uc002env.2	-	48	7330	c.7037C>T	c.(7036-7038)GCC>GTC	p.A2346V	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.A2341V|CNOT1_uc002ent.2_Missense_Mutation_p.A284V|CNOT1_uc010vik.1_Missense_Mutation_p.A1303V	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	2346					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GATTTCTGGGGCACAGTGTAC	0.398			NA											4	143					0	0	0.009096	0	0
ADAD2	161931	broad.mit.edu	37	16	84229882	84229882	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr16:84229882A>C	uc002fhr.2	+	8	1546	c.1432A>C	c.(1432-1434)ACC>CCC	p.T478P	ADAD2_uc002fhq.2_Missense_Mutation_p.T560P|uc002fhs.1_Intron	NM_001145400	NP_001138872	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2 isoform	478	A to I editase.				RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding				0						TTCCGAACCCACCCCTGACAC	0.687			NA											6	86					0	0	0.004007	0	0
TUBB3	10381	broad.mit.edu	37	16	89986023	89986023	+	Silent	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr16:89986023C>T	uc002fpf.2	+	1	765	c.357C>T	c.(355-357)GTC>GTT	p.V119V	MC1R_uc002fpe.3_Silent_p.V119V|TUBB3_uc010ciz.1_5'Flank	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	116					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		TGGACAATGTCATTGACGTGA	0.642			NA											5	51					0	0	0.001168	0	0
P2RX5	5026	broad.mit.edu	37	17	3593383	3593383	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr17:3593383G>C	uc002fwi.2	-	6	879	c.595C>G	c.(595-597)CCC>GCC	p.P199A	P2RX5_uc002fwd.2_RNA|P2RX5_uc002fwh.1_Missense_Mutation_p.P199A|P2RX5_uc010vrx.1_Missense_Mutation_p.P139A|P2RX5_uc002fwj.2_Missense_Mutation_p.P175A|P2RX5_uc002fwk.2_Missense_Mutation_p.P199A|P2RX5_uc002fwl.2_Missense_Mutation_p.P175A	NM_002561	NP_002552	Q93086	P2RX5_HUMAN	purinergic receptor P2X5 isoform A	199	Extracellular (Potential).				nervous system development|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						TTGAATTTGGGGAAACGGATG	0.582			NA											94	212					0	0	0.01441	0	0
SLFN13	146857	broad.mit.edu	37	17	33770904	33770904	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr17:33770904G>A	uc002hjk.1	-	2	1432	c.1102C>T	c.(1102-1104)CAG>TAG	p.Q368*	SLFN13_uc010wch.1_Nonsense_Mutation_p.Q368*|SLFN13_uc002hjl.2_Nonsense_Mutation_p.Q368*|SLFN13_uc010ctt.2_Nonsense_Mutation_p.Q50*|SLFN13_uc002hjm.2_Nonsense_Mutation_p.Q37*	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	368						intracellular	ATP binding	p.Q368*(1)		ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		AGACTCAACTGAGACTCAAAG	0.388			NA											8	62					0	0	0.004482	0	0
KRT27	342574	broad.mit.edu	37	17	38935859	38935859	+	Silent	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr17:38935859C>T	uc002hvg.2	-	5	908	c.867G>A	c.(865-867)CAG>CAA	p.Q289Q		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	289	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)				CGTCAGAGATCTGCTGCTGCA	0.607			NA											4	33					0	0	0.009096	0	0
KRT36	8689	broad.mit.edu	37	17	39645783	39645783	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr17:39645783G>T	uc002hwt.2	-	1	334	c.334C>A	c.(334-336)CGT>AGT	p.R112S		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	112	Rod.|Coil 1A.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				TCCAGCTGACGCACCTTCTCC	0.602			NA											5	119					0.00307968	0.00334307	0.00308	1	0
FZD2	2535	broad.mit.edu	37	17	42635739	42635739	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr17:42635739C>T	uc002igx.1	+	1	815	c.683C>T	c.(682-684)GCG>GTG	p.A228V		NM_001466	NP_001457	Q14332	FZD2_HUMAN	frizzled 2 precursor	228	Extracellular (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TGCGAACCTGCGCGGCCCGAT	0.622			NA											10	32					0	0	0.008291	0	0
ZNF652	22834	broad.mit.edu	37	17	47388720	47388720	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr17:47388720A>C	uc002iov.3	-	5	1727	c.1263T>G	c.(1261-1263)GAT>GAG	p.D421E	ZNF652_uc002iow.2_Missense_Mutation_p.D421E|ZNF652_uc002iou.3_RNA	NM_001145365	NP_001138837	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	421	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			TCATGTTGAAATCCTTGCCAC	0.433			NA											47	142					0	0	0.01441	0	0
MED13	9969	broad.mit.edu	37	17	60024297	60024297	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr17:60024297G>A	uc002izo.2	-	29	6450	c.6373C>T	c.(6373-6375)CAG>TAG	p.Q2125*		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	2125					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TCTGAAGTCTGATTTGAGTCA	0.393			NA											9	164					0	0	0.008291	0	0
OTOP3	347741	broad.mit.edu	37	17	72942967	72942967	+	Silent	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr17:72942967C>T	uc010wrr.1	+	6	1017	c.1017C>T	c.(1015-1017)TTC>TTT	p.F339F	OTOP3_uc010wrq.1_Silent_p.F321F	NM_178233	NP_839947	Q7RTS5	OTOP3_HUMAN	otopetrin 3	339	Helical; (Potential).					integral to membrane|intracellular	zinc ion binding			ovary(1)	1	all_lung(278;0.151)|Lung NSC(278;0.185)					GGGCCATCTTCGGGCCGCTGC	0.637			NA											18	138					0	0	0.007413	0	0
OTOP3	347741	broad.mit.edu	37	17	72943371	72943371	+	Missense_Mutation	SNP	G	G	A	rs149666474	byFrequency	TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr17:72943371G>A	uc010wrr.1	+	6	1421	c.1421G>A	c.(1420-1422)CGG>CAG	p.R474Q	OTOP3_uc010wrq.1_Missense_Mutation_p.R456Q	NM_178233	NP_839947	Q7RTS5	OTOP3_HUMAN	otopetrin 3	474						integral to membrane|intracellular	zinc ion binding			ovary(1)	1	all_lung(278;0.151)|Lung NSC(278;0.185)					GGCCTGCACCGGCGCCCACTC	0.662			NA											5	31					0	0	0.000602	0	0
EVPL	2125	broad.mit.edu	37	17	74004735	74004735	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr17:74004735C>G	uc002jqi.2	-	22	4779	c.4551G>C	c.(4549-4551)AAG>AAC	p.K1517N	EVPL_uc010wss.1_Missense_Mutation_p.K1539N|EVPL_uc010wst.1_Missense_Mutation_p.K987N	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1517	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						TGTAGATGGTCTTCTCCTGCG	0.602			NA											6	111					0	0	0.001984	0	0
C17orf70	80233	broad.mit.edu	37	17	79517327	79517327	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr17:79517327C>A	uc002kaq.2	-	3	1248	c.1193G>T	c.(1192-1194)AGC>ATC	p.S398I	C17orf70_uc002kao.1_5'Flank|C17orf70_uc010wuq.1_RNA|C17orf70_uc002kap.2_Missense_Mutation_p.S247I	NM_001109760	NP_001103230	Q0VG06	FP100_HUMAN	Fanconi anemia core complex 100 kDa subunit	398					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			ovary(1)|skin(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			GATGTTCAGGCTGGCTGGGCA	0.632			NA											10	155					0.00136819	0.00150501	0.013537	1	0
ANKRD30B	374860	broad.mit.edu	37	18	14803745	14803745	+	Missense_Mutation	SNP	A	A	G	rs144665862	by1000genomes	TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr18:14803745A>G	uc010dlo.2	+	24	2386	c.2206A>G	c.(2206-2208)ACT>GCT	p.T736A	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment										ovary(1)|skin(1)	2						TTTCCTTGAGACTCTCTTACA	0.289			NA											3	16					0	0	0.001168	0	0
C18orf8	29919	broad.mit.edu	37	18	21086937	21086937	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr18:21086937G>A	uc010xax.1	+	3	304	c.183G>A	c.(181-183)ATG>ATA	p.M61I	C18orf8_uc010xau.1_Intron|C18orf8_uc010xav.1_Missense_Mutation_p.M61I|C18orf8_uc010xaw.1_Intron|C18orf8_uc002kul.2_RNA	NM_013326	NP_037458	Q96DM3	MIC1_HUMAN	colon cancer-associated protein Mic1	61										ovary(1)	1	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CTTAAAGAATGGATGACAAAG	0.333			NA											37	106					0	0	0.005524	0	0
SETBP1	26040	broad.mit.edu	37	18	42643129	42643129	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr18:42643129G>C	uc010dni.2	+	6	4553	c.4257G>C	c.(4255-4257)AAG>AAC	p.K1419N		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	1419						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		ACTACACCAAGATCCTGTCCA	0.542			NA							Schinzel-Giedion_syndrome				3	20					0	0	0.004672	0	0
TNFRSF11A	8792	broad.mit.edu	37	18	60036591	60036591	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr18:60036591G>A	uc002lin.2	+	9	1479	c.1441G>A	c.(1441-1443)GAA>AAA	p.E481K	TNFRSF11A_uc010dpv.2_Intron	NM_003839	NP_003830	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily,	481	Cytoplasmic (Potential).				adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(2)|lung(1)	3		Colorectal(73;0.188)				CCTTCCCCCTGAAGAAGAAGC	0.662			NA							Paget_Disease_of_Bone				9	69					0	0	0.008291	0	0
CD226	10666	broad.mit.edu	37	18	67531647	67531647	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr18:67531647G>C	uc010dqo.2	-	6	1361	c.914C>G	c.(913-915)TCT>TGT	p.S305C	CD226_uc002lkm.3_Missense_Mutation_p.S305C	NM_006566	NP_006557	Q15762	CD226_HUMAN	CD226 molecule precursor	305	Cytoplasmic (Potential).				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity				0		Esophageal squamous(42;0.129)				TTGACTGGTAGAGATGGGACT	0.383	NSCLC(184;838 2130 8673 21498 50749)		NA											4	113					0	0	0.009096	0	0
ZNF699	374879	broad.mit.edu	37	19	9407326	9407326	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr19:9407326C>T	uc002mlc.1	-	5	754	c.754G>A	c.(754-756)GAA>AAA	p.E252K		NM_198535	NP_940937	Q32M78	ZN699_HUMAN	zinc finger protein 699	252	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCCTTACATTCATAGGGCTTC	0.418			NA											4	159					0	0	0.001984	0	0
OR10H3	26532	broad.mit.edu	37	19	15852411	15852411	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr19:15852411C>G	uc010xoq.1	+	1	209	c.209C>G	c.(208-210)TCT>TGT	p.S70C		NM_013938	NP_039226	O60404	O10H3_HUMAN	olfactory receptor, family 10, subfamily H,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTCTCCATCTCTGAGATTCTG	0.502			NA											20	230					0	0	0.008871	0	0
MYO9B	4650	broad.mit.edu	37	19	17264843	17264843	+	Silent	SNP	C	C	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr19:17264843C>G	uc010eak.2	+	5	1217	c.1065C>G	c.(1063-1065)CTC>CTG	p.L355L	MYO9B_uc002nfi.2_Silent_p.L355L|MYO9B_uc002nfj.1_Silent_p.L355L	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	355	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						AATTTCAGCTCAAGCAGCCTG	0.453			NA											4	69					0	0	0.000602	0	0
RYR1	6261	broad.mit.edu	37	19	39018359	39018359	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr19:39018359G>A	uc002oit.2	+	73	10889	c.10759G>A	c.(10759-10761)GAT>AAT	p.D3587N	RYR1_uc002oiu.2_Missense_Mutation_p.D3582N|RYR1_uc002oiv.1_Missense_Mutation_p.D502N|RYR1_uc010xuf.1_Missense_Mutation_p.D507N	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3587					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGAGGACGCCGATGACCCCGA	0.652			NA											5	59					0	0	0.000602	0	0
EIF3K	27335	broad.mit.edu	37	19	39123104	39123104	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr19:39123104G>C	uc002oiz.1	+	5	576	c.389G>C	c.(388-390)GGT>GCT	p.G130A	EIF3K_uc010xuh.1_Missense_Mutation_p.G130A|EIF3K_uc010xui.1_Missense_Mutation_p.G43A	NM_013234	NP_037366	Q9UBQ5	EIF3K_HUMAN	eukaryotic translation initiation factor 3,	130					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex|nucleus	protein binding|ribosome binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CTCTTGGAAGGTATAACTGGC	0.458			NA											12	162					0	0	0.00245	0	0
ZC3H4	23211	broad.mit.edu	37	19	47597768	47597768	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr19:47597768C>T	uc002pga.3	-	3	297	c.259G>A	c.(259-261)GGG>AGG	p.G87R	ZC3H4_uc002pgb.1_RNA	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	87							nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		TGCTTCTCCCCCTTTTCTTTC	0.522			NA											23	246					0	0	0.012319	0	0
KLK1	3816	broad.mit.edu	37	19	51323577	51323577	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr19:51323577G>A	uc002ptk.1	-	3	368	c.329C>T	c.(328-330)ACC>ATC	p.T110I	KLK1_uc010ycg.1_RNA	NM_002257	NP_002248	P06870	KLK1_HUMAN	kallikrein 1 preproprotein	110	Peptidase S1.				proteolysis	nucleus	serine-type endopeptidase activity				0		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00399)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGCTTGGCGGGTGTGGTTCTC	0.562			NA											15	91					0	0	0.003163	0	0
ZNF582	147948	broad.mit.edu	37	19	56895542	56895542	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr19:56895542C>G	uc002qmz.1	-	5	1403	c.1244G>C	c.(1243-1245)AGA>ACA	p.R415T	ZNF582_uc002qmy.2_Missense_Mutation_p.R446T	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	415	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		TGTATGAATTCTGTAATGTAC	0.403	Ovarian(183;1887 2032 4349 30507 51343)		NA											8	84					0	0	0.004482	0	0
NBAS	51594	broad.mit.edu	37	2	15629148	15629148	+	Splice_Site	SNP	T	T	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr2:15629148T>A	uc002rcc.1	-	12	981	c.955_splice	c.e12-1	p.D319_splice	NBAS_uc002rcd.1_Splice_Site	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein											ovary(2)|liver(1)|skin(1)	4						AATTCCATCCTAAATAAGAAT	0.408			NA											7	57					0	0	0.004482	0	0
C2orf16	84226	broad.mit.edu	37	2	27802858	27802858	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr2:27802858C>T	uc002rkz.3	+	1	3470	c.3419C>T	c.(3418-3420)TCG>TTG	p.S1140L		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1140										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					CAGACCACTTCGGGGCCTTAT	0.488			NA											9	146					0	0	0.006214	0	0
LRP1B	53353	broad.mit.edu	37	2	141092095	141092095	+	Silent	SNP	G	G	A	rs145423213	by1000genomes	TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr2:141092095G>A	uc002tvj.1	-	79	13122	c.12150C>T	c.(12148-12150)TCC>TCT	p.S4050S		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4050	Extracellular (Potential).|LDL-receptor class B 35.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTTCTATATGGGAATGATCCC	0.428	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			17	121					0	0	0.007413	0	0
TTN	7273	broad.mit.edu	37	2	179418768	179418768	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr2:179418768G>T	uc010zfg.1	-	282	81590	c.81366C>A	c.(81364-81366)GAC>GAA	p.D27122E	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D20817E|TTN_uc010zfi.1_Missense_Mutation_p.D20750E|TTN_uc010zfj.1_Missense_Mutation_p.D20625E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28049							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGTCTGGTGTCACGGATAG	0.418			NA											43	107					5.2432e-18	6.17949e-18	0.01441	1	0
TTN	7273	broad.mit.edu	37	2	179429186	179429186	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr2:179429186C>T	uc010zfg.1	-	275	74193	c.73969G>A	c.(73969-73971)GTA>ATA	p.V24657I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V18352I|TTN_uc010zfi.1_Missense_Mutation_p.V18285I|TTN_uc010zfj.1_Missense_Mutation_p.V18160I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25584							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTTCTAATACGTTGGTAAAG	0.383			NA											4	15					0	0	0.009096	0	0
TNS1	7145	broad.mit.edu	37	2	218712545	218712545	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr2:218712545C>T	uc002vgt.2	-	17	2718	c.2320G>A	c.(2320-2322)GGA>AGA	p.G774R	TNS1_uc002vgr.2_Missense_Mutation_p.G774R|TNS1_uc002vgs.2_Missense_Mutation_p.G774R|TNS1_uc010zjv.1_Missense_Mutation_p.G774R|TNS1_uc010fvj.1_Missense_Mutation_p.G842R|TNS1_uc010fvk.1_Missense_Mutation_p.G899R|TNS1_uc010fvi.1_Missense_Mutation_p.G461R	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	774						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TCAGGGGTTCCCAACGAATGC	0.597			NA											7	36					0	0	0.001984	0	0
DNPEP	23549	broad.mit.edu	37	2	220239731	220239731	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr2:220239731C>T	uc010zlg.1	-	14	1359	c.1277G>A	c.(1276-1278)CGG>CAG	p.R426Q	DNPEP_uc010zlf.1_RNA|DNPEP_uc002vle.2_Missense_Mutation_p.R418Q|DNPEP_uc002vlf.1_Missense_Mutation_p.R404Q|DNPEP_uc002vlh.2_Missense_Mutation_p.R365Q|DNPEP_uc002vli.1_Missense_Mutation_p.R365Q	NM_012100	NP_036232	Q9ULA0	DNPEP_HUMAN	aspartyl aminopeptidase	408					peptide metabolic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;1.09e-06)|all cancers(144;0.000179)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	L-Glutamic Acid(DB00142)	GGTGTCATTCCGGACCATGAG	0.572			NA											3	43					0	0	0.004672	0	0
PAX1	5075	broad.mit.edu	37	20	21689309	21689309	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr20:21689309G>T	uc002wsj.2	+	3	1084	c.1030G>T	c.(1030-1032)GCC>TCC	p.A344S	PAX1_uc010zsl.1_Missense_Mutation_p.A344S|PAX1_uc010zsm.1_Missense_Mutation_p.A320S	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	344					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						AGAGAAACCTGCCTTAGAGGC	0.572			NA											11	38					3.07112e-06	3.51899e-06	0.010729	1	0
CST5	1473	broad.mit.edu	37	20	23858166	23858166	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr20:23858166G>T	uc002wtr.1	-	2	388	c.321C>A	c.(319-321)TTC>TTA	p.F107L		NM_001900	NP_001891	P28325	CYTD_HUMAN	cystatin D precursor	107						extracellular region	cysteine-type endopeptidase inhibitor activity|protein binding				0						GCTGGTCATTGAAGGGACAGT	0.443			NA											10	84					1.5842e-08	1.85385e-08	0.001855	1	0
ZGPAT	84619	broad.mit.edu	37	20	62365055	62365055	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr20:62365055G>C	uc002ygk.2	+	4	1013	c.835G>C	c.(835-837)GAC>CAC	p.D279H	ZGPAT_uc002ygi.2_Missense_Mutation_p.D279H|ZGPAT_uc002ygj.2_Missense_Mutation_p.D279H|ZGPAT_uc010gkk.1_Intron|ZGPAT_uc010gkl.1_Missense_Mutation_p.D279H|ZGPAT_uc002ygm.2_Missense_Mutation_p.D279H|ZGPAT_uc002ygn.3_RNA|LIME1_uc011abi.1_5'Flank|LIME1_uc002ygp.3_5'Flank	NM_032527	NP_115916	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	279					negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					GTCCGACTCAGACAGCGACGG	0.652			NA											7	123					0	0	0.00308	0	0
PCMTD2	55251	broad.mit.edu	37	20	62891579	62891579	+	Silent	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr20:62891579G>A	uc002yil.3	+	2	461	c.261G>A	c.(259-261)CTG>CTA	p.L87L	PCMTD2_uc002yim.3_Silent_p.L87L	NM_018257	NP_060727	Q9NV79	PCMD2_HUMAN	protein-L-isoaspartate (D-aspartate)	87						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					TTCTGAACCTGGGCAGTGGCA	0.537			NA											12	134					0	0	0.001855	0	0
CYYR1	116159	broad.mit.edu	37	21	27945234	27945234	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr21:27945234C>T	uc002ymd.2	-	1	348	c.26G>A	c.(25-27)CGT>CAT	p.R9H	CYYR1_uc011ack.1_RNA|CYYR1_uc002yme.2_Missense_Mutation_p.R9H	NM_052954	NP_443186	Q96J86	CYYR1_HUMAN	cysteine and tyrosine-rich 1 protein precursor	9						integral to membrane					0						GACCCCTGGACGCACGGGTAG	0.662			NA											4	36					0	0	0.000602	0	0
DLEC1	9940	broad.mit.edu	37	3	38136442	38136442	+	Silent	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr3:38136442C>T	uc003cho.1	+	13	2013	c.1992C>T	c.(1990-1992)TTC>TTT	p.F664F	DLEC1_uc003chp.1_Silent_p.F664F|DLEC1_uc010hgv.1_Silent_p.F664F|DLEC1_uc003chr.1_5'UTR|DLEC1_uc010hgx.1_5'Flank|DLEC1_uc003chq.1_Intron	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	664					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		GAGAAACCTTCAGCATGGACA	0.582			NA											6	36					0	0	0.001168	0	0
SCN10A	6336	broad.mit.edu	37	3	38760174	38760174	+	Silent	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr3:38760174G>A	uc003ciq.2	-	20	3651	c.3651C>T	c.(3649-3651)GCC>GCT	p.A1217A		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1217	III.|Helical; Name=S3 of repeat III; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GCCAGCACCAGGCATTGGTGA	0.522			NA											9	61					0	0	0.006214	0	0
DVL3	1857	broad.mit.edu	37	3	183883995	183883995	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr3:183883995T>C	uc003fms.2	+	8	985	c.845T>C	c.(844-846)ATG>ACG	p.M282T	DVL3_uc011bqw.1_Missense_Mutation_p.M282T|DVL3_uc003fmt.2_5'UTR|DVL3_uc003fmu.2_Missense_Mutation_p.M114T	NM_004423	NP_004414	Q92997	DVL3_HUMAN	dishevelled 3	282	PDZ.				canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			ovary(1)|lung(1)|breast(1)	3	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			GGCTCTATCATGAAGGGTGGG	0.512			NA											6	57					0	0	0.001168	0	0
SENP5	205564	broad.mit.edu	37	3	196612594	196612594	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr3:196612594G>C	uc003fwz.3	+	2	791	c.542G>C	c.(541-543)GGC>GCC	p.G181A	SENP5_uc011bty.1_Missense_Mutation_p.G181A	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	181					cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		GGTGAGAGTGGCACGATTGTG	0.532	Ovarian(47;891 1095 11174 13858 51271)		NA											4	26					0	0	0.009096	0	0
LDB2	9079	broad.mit.edu	37	4	16597424	16597424	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr4:16597424G>T	uc003goz.2	-	3	626	c.310C>A	c.(310-312)CTC>ATC	p.L104I	LDB2_uc003gpa.2_Missense_Mutation_p.L104I|LDB2_uc003gpb.2_Missense_Mutation_p.L104I|LDB2_uc011bxh.1_Missense_Mutation_p.L104I|LDB2_uc010iee.2_Missense_Mutation_p.L104I|LDB2_uc003goy.2_5'UTR|LDB2_uc011bxi.1_5'UTR	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	104							LIM domain binding|transcription cofactor activity				0						GAGTGTTTGAGAATGTAATAC	0.507			NA											4	56					0.00909568	0.00955915	0.009096	1	0
GRSF1	2926	broad.mit.edu	37	4	71698055	71698055	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr4:71698055G>C	uc010iia.1	-	4	866	c.783C>G	c.(781-783)TGC>TGG	p.C261W	GRSF1_uc011caz.1_Missense_Mutation_p.C143W|GRSF1_uc003hfs.2_Missense_Mutation_p.C99W	NM_002092	NP_002083	Q12849	GRSF1_HUMAN	G-rich RNA sequence binding factor 1 isoform 1	261	RRM 2.				mRNA polyadenylation		mRNA binding|nucleotide binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			CTTTCTCATTGCAACTATAAG	0.398			NA											3	71					0	0	0.004672	0	0
KIAA1109	84162	broad.mit.edu	37	4	123268929	123268929	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr4:123268929G>A	uc003ieh.2	+	74	13169	c.13124G>A	c.(13123-13125)CGA>CAA	p.R4375Q	KIAA1109_uc003iem.2_Missense_Mutation_p.R731Q	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4375					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TCAGTTCCTCGAAGAGGTAAC	0.413			NA											5	83					0	0	0.000602	0	0
ELMOD2	255520	broad.mit.edu	37	4	141458637	141458637	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr4:141458637G>A	uc003iik.2	+	5	433	c.341G>A	c.(340-342)AGT>AAT	p.S114N		NM_153702	NP_714913	Q8IZ81	ELMD2_HUMAN	ELMO/CED-12 domain containing 2	114					phagocytosis|regulation of defense response to virus|response to virus	cytoskeleton	GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)					GATGTAGAAAGTGTGAGGAAA	0.308			NA											8	69					0	0	0.004482	0	0
FBN2	2201	broad.mit.edu	37	5	127648361	127648361	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr5:127648361C>T	uc003kuu.2	-	37	5283	c.4844G>A	c.(4843-4845)GGA>GAA	p.G1615E		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1615	TB 6.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		ACAGGGGTTTCCCCAGGCCTT	0.502			NA											26	347					0	0	0.005443	0	0
SH3TC2	79628	broad.mit.edu	37	5	148427473	148427473	+	Silent	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr5:148427473C>T	uc003lpu.2	-	3	383	c.231G>A	c.(229-231)CGG>CGA	p.R77R	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc003lpt.2_5'UTR|SH3TC2_uc010jgx.2_Silent_p.R77R|SH3TC2_uc003lpv.1_5'UTR|SH3TC2_uc011dbz.1_5'UTR|SH3TC2_uc003lpw.1_Silent_p.R77R	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	77							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGCCCAGAGCCGCCTCCGAG	0.403			NA											4	172					0	0	0.009096	0	0
OR12D2	26529	broad.mit.edu	37	6	29364564	29364564	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr6:29364564C>T	uc003nmf.3	+	1	149	c.88C>T	c.(88-90)CTC>TTC	p.L30F		NM_013936	NP_039224	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CGTGGTTTTCCTCACCATCTA	0.448			NA											19	190					0	0	0.007413	0	0
PHF3	23469	broad.mit.edu	37	6	64422504	64422504	+	Missense_Mutation	SNP	C	C	T	rs147627550		TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr6:64422504C>T	uc003pep.1	+	15	5046	c.5020C>T	c.(5020-5022)CGG>TGG	p.R1674W	PHF3_uc003pen.2_Missense_Mutation_p.R1586W|PHF3_uc011dxs.1_Missense_Mutation_p.R943W	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1674					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AGATAGTTGCCGGAATGGAGA	0.448	GBM(135;136 1820 29512 34071 46235)		NA											3	48					0	0	0.004672	0	0
MLLT4	4301	broad.mit.edu	37	6	168344625	168344625	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr6:168344625G>A	uc003qwd.2	+	25	3362	c.3220G>A	c.(3220-3222)GCA>ACA	p.A1074T	MLLT4_uc003qwb.1_Missense_Mutation_p.A1059T|MLLT4_uc003qwc.1_Missense_Mutation_p.A1075T|MLLT4_uc003qwg.1_Missense_Mutation_p.A384T	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1075	PDZ.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		TCCTAGGGCGGCAGAACTCAT	0.478			NA	T	MLL	AL								3	65					0	0	0.001168	0	0
NXPH1	30010	broad.mit.edu	37	7	8790640	8790640	+	Silent	SNP	C	C	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr7:8790640C>G	uc003srv.2	+	3	968	c.57C>G	c.(55-57)GTC>GTG	p.V19V	NXPH1_uc011jxh.1_5'UTR	NM_152745	NP_689958	P58417	NXPH1_HUMAN	neurexophilin 1 precursor	19						extracellular region				ovary(1)|central_nervous_system(1)	2		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		GTTTTCAGGTCACATGTGCCA	0.398			NA											14	101					0	0	0.003163	0	0
TMEM195	392636	broad.mit.edu	37	7	15601385	15601385	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr7:15601385G>A	uc003stb.1	-	1	256	c.86C>T	c.(85-87)TCA>TTA	p.S29L		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	29					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						TGTTTGGAATGAAGTTTCACT	0.408			NA											9	109					0	0	0.006214	0	0
MUC17	140453	broad.mit.edu	37	7	100684569	100684569	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr7:100684569C>T	uc003uxp.1	+	3	9925	c.9872C>T	c.(9871-9873)ACA>ATA	p.T3291I	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3291	Extracellular (Potential).|Ser-rich.|53.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GTCAGCACCACAACGGTGGCC	0.507			NA											36	361					0	0	0.003755	0	0
TBXAS1	6916	broad.mit.edu	37	7	139575437	139575437	+	Splice_Site	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr7:139575437G>A	uc011kqv.1	+	3	403	c.239_splice	c.e3+1	p.G80_splice	TBXAS1_uc003vvh.2_Splice_Site_p.G80_splice|TBXAS1_uc010lne.2_Splice_Site_p.G12_splice|TBXAS1_uc011kqu.1_Intron|TBXAS1_uc003vvi.2_Splice_Site_p.G80_splice|TBXAS1_uc003vvj.2_Splice_Site_p.G80_splice|TBXAS1_uc011kqw.1_Missense_Mutation_p.V51I|TBXAS1_uc011kqx.1_Splice_Site_p.G80_splice	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform						hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					CTCTGTGTGGGTAAGAAGGAA	0.353			NA											12	80					0	0	0.013537	0	0
TRY6	154754	broad.mit.edu	37	7	142480063	142480063	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr7:142480063C>A	uc011ksq.1	+	2	278	c.195C>A	c.(193-195)TAC>TAA	p.Y65*	uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_RNA|uc003wan.1_Intron|TRY6_uc011kso.1_RNA|TRY6_uc011ksr.1_RNA	NR_001296				SubName: Full=Protease, serine, 3; Flags: Fragment;												0						GTCACTGCTACAAGCCGTAAG	0.567			NA											5	72					3.10358e-05	3.50747e-05	0.014323	1	0
KRBA1	84626	broad.mit.edu	37	7	149419892	149419892	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr7:149419892G>A	uc003wfz.2	+	7	1016	c.617G>A	c.(616-618)AGC>AAC	p.S206N	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_5'Flank	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	206										ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCTGGGAACAGCCCCTTGCAA	0.622			NA											3	74					0	0	0.004672	0	0
SSPO	23145	broad.mit.edu	37	7	149523250	149523250	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr7:149523250C>T	uc010lpk.2	+	103	14333	c.14333C>T	c.(14332-14334)CCC>CTC	p.P4778L	SSPO_uc010lpm.1_RNA|SSPO_uc003wgg.2_Intron|SSPO_uc003wgh.2_RNA|SSPO_uc003wgi.1_RNA	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	4778	TSP type-1 24.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGCTCGGCCCCCTGTGGTGGG	0.642			NA											12	58					0	0	0.010729	0	0
PCM1	5108	broad.mit.edu	37	8	17804748	17804748	+	Silent	SNP	A	A	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr8:17804748A>G	uc003wyi.3	+	7	1259	c.837A>G	c.(835-837)CAA>CAG	p.Q279Q	PCM1_uc011kyh.1_Silent_p.Q279Q|PCM1_uc003wyj.3_Silent_p.Q279Q|PCM1_uc003wyg.2_Silent_p.Q279Q|PCM1_uc003wyh.2_Silent_p.Q318Q|PCM1_uc010lta.1_Silent_p.Q318Q	NM_006197	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	279	Potential.				centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)		TGAAGAAACAACATGATTTAT	0.403			NA	T	RET|JAK2	papillary thyroid|CML|MPD								11	61					0	0	0.008291	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68111195	68111195	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr8:68111195G>C	uc003xxo.1	-	39	5914	c.5524C>G	c.(5524-5526)CAG>GAG	p.Q1842E	ARFGEF1_uc003xxl.1_Intron|ARFGEF1_uc003xxm.1_Missense_Mutation_p.Q245E|ARFGEF1_uc003xxn.1_Missense_Mutation_p.Q787E|ARFGEF1_uc003xxp.1_3'UTR	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1842					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			CCAAGTTCCTGTTCAGGTGGT	0.383			NA											10	66					0	0	0.008291	0	0
PREX2	80243	broad.mit.edu	37	8	68995474	68995474	+	Splice_Site	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr8:68995474G>C	uc003xxv.1	+	18	1906	c.1879_splice	c.e18-1	p.M627_splice	PREX2_uc003xxu.1_Splice_Site_p.M627_splice|PREX2_uc011lez.1_Splice_Site_p.M562_splice	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a						G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						TTCTCTCTTAGATGGCTGGCA	0.303			NA											3	94					0	0	0.004672	0	0
VPS13B	157680	broad.mit.edu	37	8	100866417	100866417	+	Silent	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr8:100866417C>T	uc003yiv.2	+	56	10986	c.10875C>T	c.(10873-10875)TTC>TTT	p.F3625F	VPS13B_uc003yiw.2_Silent_p.F3600F	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3625					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GACCCATCTTCACCACTGCGA	0.537	Colon(161;2205 2542 7338 31318)		NA											8	36					0	0	0.010729	0	0
GPAA1	8733	broad.mit.edu	37	8	145140569	145140569	+	Silent	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr8:145140569C>T	uc003zax.2	+	11	1655	c.1545C>T	c.(1543-1545)CTC>CTT	p.L515L		NM_003801	NP_003792	O43292	GPAA1_HUMAN	glycosylphosphatidylinositol anchor attachment	515	Helical; (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein complex assembly|protein retention in ER lumen	GPI-anchor transamidase complex	tubulin binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.02e-40)|all cancers(56;2.11e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCATCGCCCTCACCAACTTCT	0.612			NA											6	65					0	0	0.001168	0	0
SHARPIN	81858	broad.mit.edu	37	8	145158011	145158011	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr8:145158011G>C	uc003zba.2	-	2	803	c.319C>G	c.(319-321)CAG>GAG	p.Q107E	SHARPIN_uc003zbb.2_RNA|MAF1_uc003zbc.1_5'Flank	NM_030974	NP_112236	Q9H0F6	SHRPN_HUMAN	shank-interacting protein-like 1	107	Self-association (By similarity).				negative regulation of inflammatory response|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein linear polyubiquitination|regulation of CD40 signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway	cytosol|LUBAC complex	polyubiquitin binding|zinc ion binding			ovary(1)	1	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.1e-42)|Epithelial(56;1.58e-40)|all cancers(56;6.12e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGAGCTTCCTGAGGGTTGAGG	0.577			NA											5	98					0	0	0.000602	0	0
KANK1	23189	broad.mit.edu	37	9	713067	713067	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr9:713067C>A	uc003zgl.1	+	7	2950	c.2301C>A	c.(2299-2301)AAC>AAA	p.N767K	KANK1_uc003zgm.2_Missense_Mutation_p.N767K|KANK1_uc003zgn.1_Missense_Mutation_p.N767K|KANK1_uc003zgo.1_Missense_Mutation_p.N767K|KANK1_uc003zgp.1_Missense_Mutation_p.N767K|KANK1_uc003zgq.2_Missense_Mutation_p.N609K|KANK1_uc003zgr.1_Missense_Mutation_p.N609K|KANK1_uc003zgs.1_Missense_Mutation_p.N609K	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	767					negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		TAAATATTAACGACAACTATC	0.522			NA											3	57					0.004672	0.00500571	0.004672	1	0
SMARCA2	6595	broad.mit.edu	37	9	2182201	2182201	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr9:2182201C>G	uc003zhc.2	+	31	4519	c.4420C>G	c.(4420-4422)CTC>GTC	p.L1474V	SMARCA2_uc003zhd.2_Missense_Mutation_p.L1456V|SMARCA2_uc010mha.2_Missense_Mutation_p.L1389V|SMARCA2_uc011llw.1_Missense_Mutation_p.L160V|SMARCA2_uc003zhf.2_Missense_Mutation_p.L138V|SMARCA2_uc011llx.1_Missense_Mutation_p.L120V|SMARCA2_uc003zhe.2_Missense_Mutation_p.L162V|SMARCA2_uc003zhg.2_Missense_Mutation_p.L120V|SMARCA2_uc010mhb.2_Missense_Mutation_p.L144V	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1474	Bromo.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		TGTCATGCTTCTCTGTCACAA	0.433			NA											13	133					0	0	0.00245	0	0
KIAA2026	158358	broad.mit.edu	37	9	5920916	5920916	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr9:5920916T>C	uc003zjq.3	-	8	5296	c.5080A>G	c.(5080-5082)ATT>GTT	p.I1694V	KIAA2026_uc010mht.2_Missense_Mutation_p.I869V	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	1694										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TTTGACAAAATAGGCATAATT	0.428			NA											11	88					0	0	0.010729	0	0
LOC442421	442421	broad.mit.edu	37	9	66499680	66499680	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr9:66499680C>A	uc004aee.1	+	1	490	c.490C>A	c.(490-492)CCC>ACC	p.P164T	LOC442421_uc004aed.1_RNA					Homo sapiens hypothetical LOC442421, mRNA (cDNA clone IMAGE:40031134).												0						TCATGTTAACCCCTTCCCAGG	0.582			NA											7	31					2.0095e-06	2.31865e-06	0.001984	1	0
FAM166A	401565	broad.mit.edu	37	9	140138730	140138730	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr9:140138730C>T	uc004cmi.1	-	6	813	c.758G>A	c.(757-759)AGA>AAA	p.R253K		NM_001001710	NP_001001710	Q6J272	F166A_HUMAN	hypothetical protein LOC401565	253										ovary(1)	1						GTGGGGGTTTCTAAACAGGAA	0.602			NA											5	34					0	0	0.000602	0	0
TLR7	51284	broad.mit.edu	37	X	12905921	12905921	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chrX:12905921C>T	uc004cvc.2	+	3	2433	c.2294C>T	c.(2293-2295)ACC>ATC	p.T765I		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	765	Extracellular (Potential).|LRR 26.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	ATCCAAAAGACCAGCTTCCCA	0.413			NA											9	164					0	0	0.006214	0	0
RS1	6247	broad.mit.edu	37	X	18660249	18660249	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chrX:18660249A>T	uc004cyo.2	-	6	585	c.550T>A	c.(550-552)TCC>ACC	p.S184T	CDKL5_uc004cym.2_Intron|CDKL5_uc004cyn.2_Intron	NM_000330	NP_000321	O15537	XLRS1_HUMAN	X-linked juvenile retinoschisis protein	184	F5/8 type C.				cell adhesion|multicellular organismal development|response to stimulus|visual perception	extracellular space				ovary(2)	2	Hepatocellular(33;0.183)					TGAACCGTGGAGGTGCGGTCC	0.587			NA											5	106					0	0	0.001168	0	0
FAM47A	158724	broad.mit.edu	37	X	34149208	34149208	+	Silent	SNP	C	C	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chrX:34149208C>A	uc004ddg.2	-	1	1221	c.1188G>T	c.(1186-1188)GTG>GTT	p.V396V		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	396										ovary(4)|central_nervous_system(1)	5						GGAGATGAGACACTTCAGTCT	0.592			NA											4	54					0.00024832	0.000276843	0.009096	1	0
USP9X	8239	broad.mit.edu	37	X	41007726	41007726	+	Silent	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chrX:41007726G>A	uc004dfb.2	+	12	2157	c.1524G>A	c.(1522-1524)TTG>TTA	p.L508L	USP9X_uc004dfc.2_Silent_p.L508L	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	508					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						ACAAAGTGTTGAACCTTCTGT	0.443	Ovarian(172;1807 2695 35459 49286)		NA											4	140					0	0	0.009096	0	0
ARAF	369	broad.mit.edu	37	X	47430737	47430737	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chrX:47430737G>C	uc011mlq.1	+	16	1835	c.1702G>C	c.(1702-1704)GAG>CAG	p.E568Q		NM_001654	NP_001645	P10398	ARAF_HUMAN	v-raf murine sarcoma 3611 viral oncogene	568	Protein kinase.				intracellular signal transduction|negative regulation of apoptosis|positive regulation of peptidyl-serine phosphorylation		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity			large_intestine(3)|lung(2)|ovary(1)|skin(1)	7					Adenosine triphosphate(DB00171)	GGCCACAATTGAGCTGCTGCA	0.607			NA											3	42					0	0	0.009096	0	0
HUWE1	10075	broad.mit.edu	37	X	53610529	53610529	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chrX:53610529T>C	uc004dsp.2	-	42	5911	c.5509A>G	c.(5509-5511)ACC>GCC	p.T1837A	HUWE1_uc004dsn.2_Missense_Mutation_p.T662A	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1837					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TTTTCCATGGTATGACGAAGG	0.438			NA											10	154					0	0	0.010729	0	0
ITIH5L	347365	broad.mit.edu	37	X	54823428	54823428	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chrX:54823428T>G	uc004dtj.2	-	2	234	c.204A>C	c.(202-204)GAA>GAC	p.E68D		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	68	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						CAAAGATGGCTTCATGGGCTT	0.448			NA											4	159					0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	X	80185205	80185205	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chrX:80185205C>T	uc004eec.1	+	1	278	c.104C>T	c.(103-105)ACG>ATG	p.T35M						SubName: Full=cDNA FLJ16670 fis, clone THYMU3001133, highly similar to Voltage-dependent anion-selective channel protein 1; SubName: Full=Voltage-dependent anion channel 1, isoform CRA_a;												NA						TACGGCCTCACGTTTACAGAG	0.473			NA											6	57					0	0	0.001168	0	0
CXorf56	63932	broad.mit.edu	37	X	118678319	118678319	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chrX:118678319C>G	uc004erk.1	-	4	466	c.420G>C	c.(418-420)AAG>AAC	p.K140N	CXorf56_uc004erj.1_Missense_Mutation_p.K91N|CXorf56_uc011mtu.1_Missense_Mutation_p.K126N	NM_022101	NP_071384	Q9H5V9	CX056_HUMAN	hypothetical protein LOC63932	140							protein binding				0						TAATTACCTTCTTAGGAGGCT	0.383			NA											18	236					0	0	0.008871	0	0
HTATSF1	27336	broad.mit.edu	37	X	135586542	135586542	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chrX:135586542G>A	uc004ezw.2	+	7	1176	c.754G>A	c.(754-756)GAG>AAG	p.E252K	HTATSF1_uc004ezx.2_Missense_Mutation_p.E252K	NM_001163280	NP_001156752	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	252					regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					TTGGAGACCTGAGAGGCGAGC	0.453			NA											4	63					0	0	0.000602	0	0
SLITRK4	139065	broad.mit.edu	37	X	142716664	142716664	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chrX:142716664T>C	uc004fbx.2	-	2	2637	c.2261A>G	c.(2260-2262)GAT>GGT	p.D754G	SLITRK4_uc004fby.2_Missense_Mutation_p.D754G	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	754	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CACATTGGAATCCCTGCTAGG	0.393			NA											74	201					0	0	0.01441	0	0
MAGEA8	4107	broad.mit.edu	37	X	149013830	149013830	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chrX:149013830C>T	uc004fdw.1	+	3	999	c.784C>T	c.(784-786)CGC>TGC	p.R262C		NM_005364	NP_005355	P43361	MAGA8_HUMAN	melanoma antigen family A, 8	262	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					CCTGGAGTACCGCCAGGCGCC	0.582			NA											15	181					0	0	0.003163	0	0
ARHGAP4	393	broad.mit.edu	37	X	153186252	153186252	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chrX:153186252G>A	uc004fjk.1	-	5	551	c.509C>T	c.(508-510)ACG>ATG	p.T170M	ARHGAP4_uc011mzf.1_Missense_Mutation_p.T147M|ARHGAP4_uc004fjl.1_Missense_Mutation_p.T170M|ARHGAP4_uc010nup.1_RNA	NM_001666	NP_001657	P98171	RHG04_HUMAN	Rho GTPase activating protein 4 isoform 2	170	Potential.				apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGCCTGGTACGTCTTCTTGGC	0.662			NA											6	116					0	0	0.001168	0	0
RBM12B	389677	broad.mit.edu	37	8	94746054	94746054	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5935-01A-11D-1753-08	TCGA-50-5935-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9570cd02-3339-4805-855a-74ebe429df96	cdef3797-3c5d-461f-92c8-1392cdd1781d	g.chr8:94746054delG	uc003yfz.2	-	3	2778	c.2585delC	c.(2584-2586)CCTfs	p.P862fs		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	862							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			AAAATTGTCAGGAAGTCTAGG	0.522			NA											19	158	---	---	---	---	NA	NA	NA	NA	NA
