Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AKR7A3	22977	broad.mit.edu	37	1	19612764	19612764	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr1:19612764C>T	uc001bbv.1	-	2	394	c.317G>A	c.(316-318)CGA>CAA	p.R106Q		NM_012067	NP_036199	O95154	ARK73_HUMAN	aldo-keto reductase family 7, member A3	106					cellular aldehyde metabolic process	cytosol	aldo-keto reductase (NADP) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;1.78e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00276)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GAGGTCCACTCGGGGACACTG	0.592			NA											15	77					0	0	0.020292	0	0
SPOCD1	90853	broad.mit.edu	37	1	32263879	32263879	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr1:32263879G>T	uc001bts.1	-	9	2132	c.2074C>A	c.(2074-2076)CTG>ATG	p.L692M	SPOCD1_uc001btt.2_Translation_Start_Site|SPOCD1_uc001btu.2_Missense_Mutation_p.L692M|SPOCD1_uc001btv.2_Missense_Mutation_p.L185M|SPOCD1_uc001btw.1_Missense_Mutation_p.L36M	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	692	TFIIS central.				transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		ATCCGCACCAGGTCGTAGGGG	0.612			NA											16	80					2.31682e-05	2.6916e-05	0.003163	1	0
MCOLN3	55283	broad.mit.edu	37	1	85487776	85487776	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr1:85487776C>T	uc001dkp.2	-	11	1390	c.1297G>A	c.(1297-1299)GTG>ATG	p.V433M	MCOLN3_uc001dko.2_Missense_Mutation_p.V52M|MCOLN3_uc001dkq.2_Missense_Mutation_p.V377M	NM_018298	NP_060768	Q8TDD5	MCLN3_HUMAN	mucolipin 3	433	Helical; (Potential).					integral to membrane	ion channel activity			skin(1)	1				all cancers(265;0.00957)|Epithelial(280;0.0254)		GGCCCCAGCACGATCCATCCA	0.448			NA											6	76					0	0	0.001984	0	0
HIST2H2AB	317772	broad.mit.edu	37	1	149859288	149859288	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr1:149859288G>C	uc001ete.2	-	1	179	c.179C>G	c.(178-180)ACC>AGC	p.T60S	HIST2H2BE_uc001etc.2_5'Flank	NM_175065	NP_778235	Q8IUE6	H2A2B_HUMAN	histone cluster 2, H2ab	60					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|breast(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			AATTTCCGCGGTCAGGTACTC	0.662			NA											12	83					0	0	0.013537	0	0
KLHL20	27252	broad.mit.edu	37	1	173735414	173735414	+	Silent	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr1:173735414C>T	uc001gjc.2	+	8	1460	c.1281C>T	c.(1279-1281)CTC>CTT	p.L427L	KLHL20_uc010pmr.1_Silent_p.L238L|KLHL20_uc009wwf.2_Silent_p.L409L	NM_014458	NP_055273	Q9Y2M5	KLH20_HUMAN	kelch-like 20	427	Kelch 3.				cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			ovary(1)	1						TGTCTTGCCTCAACATTGTTG	0.383	GBM(159;862 2695 6559 23041)		NA											9	145					0	0	0.004482	0	0
GPR52	9293	broad.mit.edu	37	1	174417353	174417353	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr1:174417353G>C	uc001gka.1	+	1	142	c.104G>C	c.(103-105)AGT>ACT	p.S35T	RABGAP1L_uc001gjw.2_Intron|RABGAP1L_uc001gjx.2_Intron|RABGAP1L_uc001gjy.2_Intron|RABGAP1L_uc001gjz.2_Intron	NM_005684	NP_005675	Q9Y2T5	GPR52_HUMAN	G protein-coupled receptor 52	35	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			skin(1)	1						GGCCACTACAGTGTGGTGGAT	0.463	Ovarian(92;924 1390 1930 16467 40583)		NA											10	57					0	0	0.006214	0	0
FAM5C	339479	broad.mit.edu	37	1	190068056	190068056	+	Missense_Mutation	SNP	T	T	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr1:190068056T>A	uc001gse.1	-	8	1625	c.1393A>T	c.(1393-1395)ACC>TCC	p.T465S	FAM5C_uc010pot.1_Missense_Mutation_p.T363S	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	465						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					ATGTAGCCGGTGTTGCAGGTG	0.607			NA											9	124					0	0	0.008291	0	0
FAIM3	9214	broad.mit.edu	37	1	207085276	207085276	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr1:207085276C>T	uc001hey.2	-	4	688	c.509G>A	c.(508-510)GGC>GAC	p.G170D	FAIM3_uc010prz.1_Missense_Mutation_p.G58D|FAIM3_uc010psa.1_Missense_Mutation_p.G79D|FAIM3_uc010psb.1_Missense_Mutation_p.G170D	NM_005449	NP_005440	O60667	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3 isoform a	170	Extracellular (Potential).				anti-apoptosis|cellular defense response	integral to membrane				central_nervous_system(1)	1	Breast(84;0.201)					AGGGACCTTGCCCCTTTGAGC	0.438			NA									OREG0014185	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	51					0	0	0.009096	0	0
PPP2R5A	5525	broad.mit.edu	37	1	212521742	212521742	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr1:212521742G>C	uc001hjb.2	+	7	1350	c.776G>C	c.(775-777)GGC>GCC	p.G259A	PPP2R5A_uc010ptd.1_Missense_Mutation_p.G200A	NM_006243	NP_006234	Q15172	2A5A_HUMAN	protein phosphatase 2, regulatory subunit B	259					negative regulation of establishment of protein localization in plasma membrane|negative regulation of lipid kinase activity|positive regulation of protein dephosphorylation|signal transduction	chromosome, centromeric region|cytoplasm|nucleus|protein phosphatase type 2A complex	kinase binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0125)|all cancers(67;0.029)|Epithelial(68;0.154)|GBM - Glioblastoma multiforme(131;0.155)		ATTATCAATGGCTTTGCATTG	0.373			NA											3	70					0	0	0.009096	0	0
NLRP3	114548	broad.mit.edu	37	1	247588806	247588806	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr1:247588806G>C	uc001icr.2	+	5	2199	c.2061G>C	c.(2059-2061)ATG>ATC	p.M687I	NLRP3_uc001ics.2_Missense_Mutation_p.M687I|NLRP3_uc001icu.2_Missense_Mutation_p.M687I|NLRP3_uc001icw.2_Missense_Mutation_p.M687I|NLRP3_uc001icv.2_Missense_Mutation_p.M687I|NLRP3_uc010pyw.1_Missense_Mutation_p.M685I|NLRP3_uc001ict.1_Missense_Mutation_p.M685I	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	687					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TCCATAACATGCCCAAGGAGG	0.512			NA											6	70					0	0	0.001168	0	0
OR2M7	391196	broad.mit.edu	37	1	248487204	248487204	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr1:248487204G>C	uc010pzk.1	-	1	667	c.667C>G	c.(667-669)CTG>GTG	p.L223V		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	223	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATGACAGCCAGAATAACTCGA	0.423			NA											5	409					0	0	0.001168	0	0
OR2T11	127077	broad.mit.edu	37	1	248790051	248790051	+	Silent	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr1:248790051G>A	uc001ier.1	-	1	379	c.379C>T	c.(379-381)CTG>TTG	p.L127L		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	127	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGGTATCTCAGAGGGTTACAG	0.547			NA											5	83					0	0	0.014758	0	0
MYST4	23522	broad.mit.edu	37	10	76788256	76788256	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr10:76788256A>G	uc001jwn.1	+	18	4167	c.3674A>G	c.(3673-3675)AAT>AGT	p.N1225S	MYST4_uc001jwo.1_Missense_Mutation_p.N933S|MYST4_uc001jwp.1_Missense_Mutation_p.N1042S	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1225					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					GACAATATGAATGATGATTCA	0.373			NA	T	CREBBP	AML								7	122					0	0	0.006214	0	0
KCNMA1	3778	broad.mit.edu	37	10	78674704	78674704	+	Silent	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr10:78674704G>A	uc001jxn.2	-	24	3183	c.3006C>T	c.(3004-3006)ATC>ATT	p.I1002I	KCNMA1_uc001jxj.2_Silent_p.I948I|KCNMA1_uc001jxk.1_Silent_p.I620I|KCNMA1_uc009xrt.1_Silent_p.I793I|KCNMA1_uc001jxl.1_Silent_p.I627I|KCNMA1_uc001jxo.2_Silent_p.I985I|KCNMA1_uc001jxm.2_Silent_p.I944I|KCNMA1_uc001jxq.2_Silent_p.I947I	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	1002	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CTAGTTCAGTGATGATGGGGA	0.473			NA											10	233					0	0	0.020292	0	0
SORCS1	114815	broad.mit.edu	37	10	108366980	108366980	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr10:108366980G>T	uc001kym.2	-	23	3117	c.3109C>A	c.(3109-3111)CTA>ATA	p.L1037I	SORCS1_uc001kyl.2_Missense_Mutation_p.L1037I|SORCS1_uc009xxs.2_Missense_Mutation_p.L1037I|SORCS1_uc001kyn.1_Missense_Mutation_p.L1037I|SORCS1_uc001kyo.2_Missense_Mutation_p.L1037I	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	1037	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TGATAGGGTAGGACAAAGAGT	0.562			NA											10	70					4.3838e-07	5.24728e-07	0.016723	1	0
PNLIP	5406	broad.mit.edu	37	10	118306827	118306827	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr10:118306827G>A	uc001lcm.2	+	3	111	c.68G>A	c.(67-69)AGA>AAA	p.R23K		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	23					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TGCTACGAAAGACTCGGCTGC	0.428			NA											7	82					0	0	0.00308	0	0
BAG3	9531	broad.mit.edu	37	10	121431869	121431869	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr10:121431869G>T	uc001lem.2	+	3	916	c.610G>T	c.(610-612)GGG>TGG	p.G204W	BAG3_uc001lel.2_Missense_Mutation_p.G204W	NM_004281	NP_004272	O95817	BAG3_HUMAN	BCL2-associated athanogene 3	204					anti-apoptosis|apoptosis|protein folding	cytosol				ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00187)|BRCA - Breast invasive adenocarcinoma(275;0.148)		GCTCCCGCGGGGGTACATCTC	0.647			NA											13	68					4.36969e-10	5.39384e-10	0.016723	1	0
DPYSL4	10570	broad.mit.edu	37	10	134006229	134006229	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr10:134006229C>G	uc009ybb.2	+	3	350	c.196C>G	c.(196-198)CTT>GTT	p.L66V		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	66					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		CCTGATGGTCCTTCCTGGTGG	0.582			NA											3	64					0	0	0.004672	0	0
ADAM8	101	broad.mit.edu	37	10	135084565	135084565	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr10:135084565C>A	uc010qva.1	-	13	1318	c.1267G>T	c.(1267-1269)GCT>TCT	p.A423S	ADAM8_uc010quz.1_Missense_Mutation_p.A462S|ADAM8_uc009ybi.2_Missense_Mutation_p.A462S			P78325	ADAM8_HUMAN	SubName: Full=cDNA FLJ50704, highly similar to ADAM 8 (EC 3.4.24.-) (A disintegrinand metalloproteinase domain 8);	423					integrin-mediated signaling pathway|proteolysis		metalloendopeptidase activity			large_intestine(2)|central_nervous_system(1)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;7.72e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.23e-06)|Epithelial(32;1.02e-05)		AGCTCACCAGCCGGCTTCACC	0.657			NA											7	33					8.12818e-05	9.23923e-05	0.001984	1	0
RAG1	5896	broad.mit.edu	37	11	36597424	36597424	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr11:36597424C>T	uc001mwu.3	+	2	2694	c.2570C>T	c.(2569-2571)GCC>GTC	p.A857V	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	857					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				GGCAACTTTGCCAGGAAGCTC	0.498	Pancreas(43;321 1249 3212 48200)|Esophageal Squamous(38;49 1003 17530 24363)		NA							Familial_Hemophagocytic_Lymphohistiocytosis				4	84					0	0	0.009096	0	0
CD5	921	broad.mit.edu	37	11	60885646	60885646	+	Splice_Site	SNP	G	G	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr11:60885646G>C	uc009ynk.2	+	3	198	c.95_splice	c.e3-1	p.D32_splice		NM_014207	NP_055022	P06127	CD5_HUMAN	CD5 molecule precursor						cell proliferation|cell recognition	integral to plasma membrane	scavenger receptor activity			ovary(1)	1		all_lung(304;5.94e-05)|Lung NSC(402;7.26e-05)		BRCA - Breast invasive adenocarcinoma(625;0.000946)|Lung(977;0.0086)|LUSC - Lung squamous cell carcinoma(625;0.0528)		CTGACCCCCAGATTTCCAGGC	0.637			NA											5	94					0	0	0.001168	0	0
PLCB3	5331	broad.mit.edu	37	11	64021894	64021894	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr11:64021894C>T	uc001nzb.2	+	2	107	c.107C>T	c.(106-108)TCC>TTC	p.S36F	PLCB3_uc009ypg.1_Missense_Mutation_p.S36F|PLCB3_uc009yph.1_Intron|PLCB3_uc009ypi.2_Missense_Mutation_p.S36F	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	36					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						CAGGAGACCTCCAGTCGGAAC	0.652			NA											14	157					0	0	0.00499	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64603314	64603314	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr11:64603314G>C	uc001obs.3	-	14	1678	c.1678C>G	c.(1678-1680)CAG>GAG	p.Q560E		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	560	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						GAGGACACCTGGGCCTCCAGC	0.657			NA											4	7					0	0	0.014758	0	0
ODZ4	26011	broad.mit.edu	37	11	78413335	78413335	+	Silent	SNP	G	G	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr11:78413335G>T	uc001ozl.3	-	28	4786	c.4323C>A	c.(4321-4323)GTC>GTA	p.V1441V	ODZ4_uc009yvb.1_Silent_p.V25V	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1441	Extracellular (Potential).|NHL 4.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GCCTCCCGGCGACAATGCGCA	0.567			NA											11	90					4.68919e-08	5.69917e-08	0.008291	1	0
NAALAD2	10003	broad.mit.edu	37	11	89883707	89883707	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr11:89883707G>C	uc001pdf.3	+	5	650	c.541G>C	c.(541-543)GAG>CAG	p.E181Q	NAALAD2_uc009yvx.2_Missense_Mutation_p.E181Q|NAALAD2_uc009yvy.2_Missense_Mutation_p.E181Q|NAALAD2_uc001pdd.2_Missense_Mutation_p.E181Q|NAALAD2_uc001pde.2_Missense_Mutation_p.E181Q	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	181	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				ACTAGAAAGAGAGATGGGCAT	0.318			NA											4	72					0	0	0.014758	0	0
C11orf1	64776	broad.mit.edu	37	11	111750308	111750308	+	Silent	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr11:111750308C>T	uc001pmd.2	+	1	361	c.24C>T	c.(22-24)TGC>TGT	p.C8C	ALG9_uc010rwo.1_5'Flank|FDXACB1_uc009yyi.2_5'Flank|FDXACB1_uc001pmc.3_5'Flank|C11orf1_uc001pme.2_5'Flank	NM_022761	NP_073598	Q9H5F2	CK001_HUMAN	hypothetical protein LOC64776	8						nucleus					0		all_cancers(61;1.26e-15)|all_epithelial(67;9.52e-10)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|Medulloblastoma(222;0.0228)|all_neural(223;0.0281)		all cancers(92;6.28e-09)|Epithelial(105;4.11e-08)|OV - Ovarian serous cystadenocarcinoma(223;1.52e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)		AGTGTCTCTGCTGCTCAAAAT	0.348			NA											47	348					0	0	0.01441	0	0
C2CD2L	9854	broad.mit.edu	37	11	118984675	118984675	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr11:118984675C>T	uc001pvo.2	+	12	1959	c.1600C>T	c.(1600-1602)CTC>TTC	p.L534F	C2CD2L_uc001pvn.2_Missense_Mutation_p.L535F	NM_014807	NP_055622	O14523	C2C2L_HUMAN	transmembrane protein 24	534						integral to membrane					0						GCGCAGCACTCTCATCATCTC	0.587			NA											3	47					0	0	0.004672	0	0
A2ML1	144568	broad.mit.edu	37	12	9013866	9013866	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr12:9013866C>A	uc001quz.3	+	28	3573	c.3475C>A	c.(3475-3477)CAG>AAG	p.Q1159K	A2ML1_uc001qva.1_Missense_Mutation_p.Q739K|A2ML1_uc010sgm.1_Missense_Mutation_p.Q659K	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	1003						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						TCTCCTTAAACAGTTAGATCA	0.438			NA											14	129					1.52009e-12	1.90615e-12	0.003163	1	0
RPL13AP20	387841	broad.mit.edu	37	12	13028751	13028751	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr12:13028751G>C	uc010sho.1	+	1	341	c.319G>C	c.(319-321)GGC>CGC	p.G107R		NR_003932				SubName: Full=Ribosomal protein L13a variant; Flags: Fragment;												0						GGTGTTTGACGGCATCCCACC	0.612			NA											3	21					0	0	0.004672	0	0
KRT3	3850	broad.mit.edu	37	12	53185017	53185017	+	Missense_Mutation	SNP	C	C	T	rs60410063		TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr12:53185017C>T	uc001say.2	-	7	1574	c.1508G>A	c.(1507-1509)CGC>CAC	p.R503H		NM_057088	NP_476429	P12035	K2C3_HUMAN	keratin 3	503	Rod.|Coil 2.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity				0						CAGCAGCTTGCGGTAGGTGGC	0.607			NA											4	118					0	0	0.014758	0	0
PDE1B	5153	broad.mit.edu	37	12	54968993	54968993	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr12:54968993C>G	uc001sgd.1	+	11	1342	c.1176C>G	c.(1174-1176)TTC>TTG	p.F392L	PDE1B_uc010soz.1_Missense_Mutation_p.F255L|PDE1B_uc010spa.1_Missense_Mutation_p.F351L|PDE1B_uc001sgf.2_Missense_Mutation_p.F255L|PDE1B_uc001sge.2_Missense_Mutation_p.F372L|PDE1B_uc009znq.2_Missense_Mutation_p.F188L	NM_000924	NP_000915	Q01064	PDE1B_HUMAN	phosphodiesterase 1B isoform 1	392	Catalytic (By similarity).				activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						TGGAGGAATTCTTCCGTCAGG	0.577			NA											3	102					0	0	0.009096	0	0
SRGAP1	57522	broad.mit.edu	37	12	64472704	64472704	+	Silent	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr12:64472704G>A	uc010ssp.1	+	9	1187	c.1131G>A	c.(1129-1131)AAG>AAA	p.K377K	SRGAP1_uc001srt.2_Silent_p.K377K|SRGAP1_uc001srv.2_Silent_p.K337K	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	377	Potential.				axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		CCCAGGTTAAGAAAACGACTG	0.299			NA											3	44					0	0	0.004672	0	0
WIF1	11197	broad.mit.edu	37	12	65445189	65445189	+	Silent	SNP	C	C	T	rs148339341		TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr12:65445189C>T	uc001ssk.2	-	10	1225	c.1080G>A	c.(1078-1080)ACG>ACA	p.T360T		NM_007191	NP_009122	Q9Y5W5	WIF1_HUMAN	WNT inhibitory factor 1 precursor	360					multicellular organismal development|Wnt receptor signaling pathway	extracellular region	protein tyrosine kinase activity			ovary(2)|lung(1)|skin(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0231)		TAAGTGAAGGCGTGTGCTGCC	0.493	Esophageal Squamous(148;1595 1816 48559 49439 49664)		NA	T	HMGA2	pleomorphic salivary gland adenoma								10	52					0	0	0.008291	0	0
UHRF1BP1L	23074	broad.mit.edu	37	12	100453666	100453666	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr12:100453666C>A	uc001tgq.2	-	13	1934	c.1705G>T	c.(1705-1707)GAG>TAG	p.E569*	UHRF1BP1L_uc001tgp.2_Nonsense_Mutation_p.E219*	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	569										ovary(2)	2						TCAACATGCTCGTCAGATTTT	0.308			NA											4	63					1.23904e-05	1.45014e-05	0.014758	1	0
ANAPC7	51434	broad.mit.edu	37	12	110813919	110813919	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr12:110813919G>A	uc001tqo.2	-	10	1563	c.1562C>T	c.(1561-1563)GCT>GTT	p.A521V	ANAPC7_uc001tqp.3_Missense_Mutation_p.A521V	NM_016238	NP_057322	Q9UJX3	APC7_HUMAN	anaphase-promoting complex subunit 7 isoform a	521	TPR 7.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding				0						CTCATTGACAGCTACAAGGAA	0.493			NA											3	68					0	0	0.004672	0	0
RNF6	6049	broad.mit.edu	37	13	26789520	26789520	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr13:26789520C>G	uc001uqo.2	-	5	790	c.499G>C	c.(499-501)GAA>CAA	p.E167Q	RNF6_uc001uqn.1_Intron|RNF6_uc010aak.2_Missense_Mutation_p.E167Q|RNF6_uc001uqp.2_Missense_Mutation_p.E167Q|RNF6_uc001uqq.2_Missense_Mutation_p.E167Q|RNF6_uc010tdk.1_Intron	NM_183044	NP_898865	Q9Y252	RNF6_HUMAN	ring finger protein 6	167					negative regulation of axon extension|positive regulation of transcription, DNA-dependent|protein K27-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|regulation of androgen receptor signaling pathway|ubiquitin-dependent protein catabolic process	axon|cytoplasm|PML body	androgen receptor binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.00893)|Epithelial(112;0.0481)|OV - Ovarian serous cystadenocarcinoma(117;0.148)|GBM - Glioblastoma multiforme(144;0.23)|Lung(94;0.245)		GTATAATCTTCTCCATGAATT	0.403			NA											14	110					0	0	0.016723	0	0
MYO16	23026	broad.mit.edu	37	13	109707855	109707855	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr13:109707855C>T	uc001vqt.1	+	27	3307	c.3181C>T	c.(3181-3183)CAG>TAG	p.Q1061*	MYO16_uc010agk.1_Nonsense_Mutation_p.Q1083*|MYO16_uc001vqu.1_Nonsense_Mutation_p.Q861*|MYO16_uc010tjh.1_Nonsense_Mutation_p.Q573*	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1061	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CGTGTCTGCTCAGCTACAATA	0.418			NA											8	121					0	0	0.006214	0	0
MTHFD1	4522	broad.mit.edu	37	14	64911421	64911421	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr14:64911421G>A	uc001xhb.2	+	22	2534	c.2147G>A	c.(2146-2148)GGA>GAA	p.G716E	MTHFD1_uc010aqf.2_Missense_Mutation_p.G772E	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1	716	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	GTCACTGCTGGACTGCCTCTT	0.443	Colon(18;220 581 13419 18191 31512)|GBM(126;343 1658 28700 44425 52519)		NA											4	88					0	0	0.014758	0	0
C14orf145	145508	broad.mit.edu	37	14	81251329	81251329	+	Silent	SNP	C	C	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr14:81251329C>A	uc001xux.2	-	14	2292	c.2121G>T	c.(2119-2121)GTG>GTT	p.V707V	C14orf145_uc010asz.1_RNA	NM_152446	NP_689659	Q6ZU80	CE128_HUMAN	hypothetical protein LOC145508	707	Potential.					centriole|spindle pole					0				BRCA - Breast invasive adenocarcinoma(234;0.0586)		GTTTTGTTTTCACACTCTGCA	0.433			NA											44	173					2.59497e-14	3.30649e-14	0.007835	1	0
GABRG3	2567	broad.mit.edu	37	15	27772717	27772717	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr15:27772717C>T	uc001zbg.1	+	8	1170	c.1004C>T	c.(1003-1005)GCC>GTC	p.A335V		NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	335	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		ATGGAGTATGCCACCCTCAAC	0.547	NSCLC(114;800 1656 7410 37729 45293)		NA											3	25					0	0	0.004672	0	0
FMN1	342184	broad.mit.edu	37	15	33359007	33359007	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr15:33359007C>T	uc001zhf.3	-	1	1079	c.1079G>A	c.(1078-1080)GGA>GAA	p.G360E	FMN1_uc001zhg.2_Missense_Mutation_p.G360E	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		AGGGTCTGCTCCCTTCGGTTC	0.567			NA											9	118					0	0	0.006214	0	0
SLTM	79811	broad.mit.edu	37	15	59192058	59192058	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr15:59192058T>C	uc002afp.2	-	7	756	c.668A>G	c.(667-669)CAC>CGC	p.H223R	SLTM_uc002afo.2_Missense_Mutation_p.H205R|SLTM_uc002afq.2_Intron|SLTM_uc010bgd.2_Intron|SLTM_uc002afr.1_Missense_Mutation_p.H122R	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	223	Glu-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						ATGAGCTGTGTGATCAGCCTC	0.453			NA											4	88					0	0	0.009096	0	0
PKD1	5310	broad.mit.edu	37	16	2160594	2160594	+	Missense_Mutation	SNP	A	A	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr16:2160594A>C	uc002cos.1	-	15	4783	c.4574T>G	c.(4573-4575)GTT>GGT	p.V1525G	PKD1_uc002cot.1_Missense_Mutation_p.V1525G	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	1525	Extracellular (Potential).|PKD 10.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						GGCCACCCTAACGGTGAAGTC	0.677			NA											14	33					0	0	0.020292	0	0
RRN3P1	730092	broad.mit.edu	37	16	21817457	21817457	+	Silent	SNP	G	G	A	rs150520281	by1000genomes	TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr16:21817457G>A	uc010vbl.1	-	7	603	c.106C>T	c.(106-108)CTG>TTG	p.L36L	uc002diq.3_Intron	NR_003370				SubName: Full=Putative uncharacterized protein ENSP00000219758;												0						CTTACATCCAGCTTGAGTAGT	0.254			NA											3	18					0	0	0.009096	0	0
IL21R	50615	broad.mit.edu	37	16	27454340	27454340	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr16:27454340C>A	uc002doq.1	+	5	643	c.410C>A	c.(409-411)TCC>TAC	p.S137Y	IL21R_uc002dor.1_Missense_Mutation_p.S137Y|IL21R_uc002dos.1_Missense_Mutation_p.S137Y	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	137	Extracellular (Potential).|Fibronectin type-III.				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						TATAATATCTCCTGGCGCTCA	0.522			NA	T	BCL6	NHL								13	128					0.000219431	0.000245888	0.020292	1	0
TP53	7157	broad.mit.edu	37	17	7578382	7578382	+	Nonsense_Mutation	SNP	G	G	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr17:7578382G>C	uc002gim.2	-	5	742	c.548C>G	c.(547-549)TCA>TGA	p.S183*	TP53_uc002gig.1_Nonsense_Mutation_p.S183*|TP53_uc002gih.2_Nonsense_Mutation_p.S183*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.S51*|TP53_uc010cng.1_Nonsense_Mutation_p.S51*|TP53_uc002gii.1_Nonsense_Mutation_p.S51*|TP53_uc010cnh.1_Nonsense_Mutation_p.S183*|TP53_uc010cni.1_Nonsense_Mutation_p.S183*|TP53_uc002gij.2_Nonsense_Mutation_p.S183*|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Nonsense_Mutation_p.S90*|TP53_uc002gio.2_Nonsense_Mutation_p.S51*|TP53_uc010vug.1_Nonsense_Mutation_p.S144*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	183	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		S -> P (in sporadic cancers; somatic mutation).|S -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S183*(21)|p.0?(7)|p.R174fs*24(3)|p.S183P(3)|p.?(2)|p.S183L(2)|p.V173fs*59(2)|p.K164_P219del(1)|p.E180_S183del(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R81fs*24(1)|p.R42fs*24(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATCGCTATCTGAGCAGCGCTC	0.647	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			4	49					0	0	0.009096	0	0
TP53	7157	broad.mit.edu	37	17	7578406	7578406	+	Missense_Mutation	SNP	C	C	T	rs28934578		TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	Pancreas(47;798 1329 9957 10801)	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			7	69					0	0	0.004482	0	0
TEKT3	64518	broad.mit.edu	37	17	15207417	15207417	+	Missense_Mutation	SNP	G	G	A	rs148345040	byFrequency	TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr17:15207417G>A	uc002gon.2	-	9	1496	c.1309C>T	c.(1309-1311)CGC>TGC	p.R437C		NM_031898	NP_114104	Q9BXF9	TEKT3_HUMAN	tektin 3	437	Potential.				microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		TCCCTCAGGCGCTGCTGCAGG	0.542			NA											6	53					0	0	0.00308	0	0
SMCR8	140775	broad.mit.edu	37	17	18219416	18219416	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr17:18219416G>A	uc002gsy.3	+	1	823	c.313G>A	c.(313-315)GGC>AGC	p.G105S		NM_144775	NP_658988	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region,	105										central_nervous_system(1)	1						TTCCTTCGTGGGCCATCCTCC	0.517			NA											28	171					0	0	0.00632	0	0
KRT23	25984	broad.mit.edu	37	17	39092763	39092763	+	Silent	SNP	A	A	G			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr17:39092763A>G	uc002hvm.1	-	2	682	c.93T>C	c.(91-93)GCT>GCC	p.A31A	KRT23_uc010wfl.1_Intron|KRT23_uc010cxf.1_Intron|KRT23_uc010cxg.2_Silent_p.A31A|KRT23_uc002hvn.1_Silent_p.A31A	NM_015515	NP_056330	Q9C075	K1C23_HUMAN	keratin 23	31	Head.					intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)|Ovarian(249;0.15)				GGACGGTGGGAGCCCTGGGGA	0.692			NA											5	43					0	0	0.014758	0	0
MED13	9969	broad.mit.edu	37	17	60039133	60039133	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr17:60039133G>A	uc002izo.2	-	22	5149	c.5072C>T	c.(5071-5073)CCT>CTT	p.P1691L		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1691					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						GTACTGACAAGGAATAATCTA	0.373			NA											9	122					0	0	0.004482	0	0
ACE	1636	broad.mit.edu	37	17	61559918	61559918	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr17:61559918C>G	uc002jau.1	+	8	1232	c.1210C>G	c.(1210-1212)CTG>GTG	p.L404V	ACE_uc010wpi.1_Missense_Mutation_p.L404V|ACE_uc010ddu.1_Missense_Mutation_p.L221V|ACE_uc002jav.1_5'Flank|ACE_uc010ddv.1_5'Flank|ACE_uc010wpj.1_5'Flank|ACE_uc002jaw.1_5'Flank|ACE_uc010wpk.1_5'Flank	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	404	Extracellular (Potential).|Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GTACAAGGATCTGCCCGTCTC	0.597			NA											7	97					0	0	0.00308	0	0
DSG2	1829	broad.mit.edu	37	18	29104409	29104409	+	Splice_Site	SNP	A	A	G			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr18:29104409A>G	uc002kwu.3	+	7	879	c.691_splice	c.e7-2	p.E231_splice		NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein						cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			ATTGCTCTGCAGGAACACAGC	0.398			NA											8	31					0	0	0.00308	0	0
TNPO2	30000	broad.mit.edu	37	19	12813730	12813730	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr19:12813730C>T	uc002muo.2	-	20	2397	c.2212G>A	c.(2212-2214)GCA>ACA	p.A738T	TNPO2_uc002mup.2_Missense_Mutation_p.A830T|TNPO2_uc002muq.2_Missense_Mutation_p.A738T|TNPO2_uc002mur.2_Missense_Mutation_p.A738T	NM_001136196	NP_001129668	O14787	TNPO2_HUMAN	transportin 2 (importin 3, karyopherin beta 2b)	738	HEAT 12.				intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			ovary(1)	1						TGCATCTCTGCCCCTGGGGGA	0.612			NA											27	140					0	0	0.005443	0	0
LPHN1	22859	broad.mit.edu	37	19	14262269	14262269	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr19:14262269C>T	uc010xnn.1	-	24	4137	c.3841G>A	c.(3841-3843)GAG>AAG	p.E1281K	LPHN1_uc010xno.1_Missense_Mutation_p.E1276K|uc002myf.2_Intron	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	1281	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5						ATCATCTTCTCAAAGGCCGCC	0.652			NA											5	36					0	0	0.014758	0	0
RFXANK	8625	broad.mit.edu	37	19	19312474	19312474	+	Silent	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr19:19312474G>A	uc002nls.2	+	10	1234	c.729G>A	c.(727-729)GAG>GAA	p.E243E	RFXANK_uc002nlt.2_Silent_p.E220E|RFXANK_uc002nlu.2_Silent_p.E221E|RFXANK_uc002nlv.2_Silent_p.E243E|RFXANK_uc002nlw.2_Silent_p.E242E|NR2C2AP_uc010xqq.1_Intron|NR2C2AP_uc002nlx.2_3'UTR|NR2C2AP_uc002nly.2_3'UTR	NM_003721	NP_003712	O14593	RFXK_HUMAN	regulatory factor X-associated	243	ANK 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(2)	2			Epithelial(12;0.00228)			AGGTGATCGAGAACCACATCC	0.597			NA											6	111					0	0	0.001168	0	0
IL29	282618	broad.mit.edu	37	19	39789087	39789087	+	Silent	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr19:39789087G>A	uc002okv.2	+	5	631	c.534G>A	c.(532-534)ACG>ACA	p.T178T		NM_172140	NP_742152	Q8IU54	IL29_HUMAN	interleukin 29 precursor	178					defense response to virus|negative regulation of cell proliferation|negative regulation of interleukin-13 production|negative regulation of interleukin-5 production|negative regulation of memory T cell differentiation|negative regulation of transcription, DNA-dependent|negative regulation of type 2 immune response|positive regulation of immune response|positive regulation of interferon-gamma production|positive regulation of MHC class I biosynthetic process|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of STAT protein	extracellular space|interleukin-28 receptor complex	cytokine activity|interleukin-28 receptor binding				0	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GCCTCCTCACGCGAGACCTCA	0.602			NA											5	121					0	0	0.014758	0	0
ZNF428	126299	broad.mit.edu	37	19	44112203	44112203	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr19:44112203C>T	uc002oxa.2	-	3	568	c.133G>A	c.(133-135)GAA>AAA	p.E45K	SRRM5_uc002oxb.2_Intron	NM_182498	NP_872304	Q96B54	ZN428_HUMAN	zinc finger protein 428	45	Glu-rich.					intracellular	zinc ion binding				0		Prostate(69;0.0153)				tcatcttcttcctcttcGGAG	0.483			NA											13	39					0	0	0.016723	0	0
ZNF226	7769	broad.mit.edu	37	19	44681620	44681620	+	Silent	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr19:44681620C>T	uc002oyp.2	+	6	2349	c.2205C>T	c.(2203-2205)GTC>GTT	p.V735V	ZNF226_uc002oyq.2_Silent_p.V618V|ZNF226_uc002oyr.2_Silent_p.V618V|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Silent_p.V735V|ZNF226_uc002oyt.2_Silent_p.V735V	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	735	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				GTGGTAAAGTCTTCAGTCGGT	0.448	Pancreas(115;581 1665 13228 19278 50070)		NA											13	142					0	0	0.016723	0	0
KCNA7	3743	broad.mit.edu	37	19	49575293	49575293	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr19:49575293C>T	uc002pmg.2	-	1	906	c.550G>A	c.(550-552)GGC>AGC	p.G184S		NM_031886	NP_114092	Q96RP8	KCNA7_HUMAN	potassium voltage-gated channel, shaker-related	184						voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)	1		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_epithelial(76;3.83e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000397)|OV - Ovarian serous cystadenocarcinoma(262;0.000519)|GBM - Glioblastoma multiforme(486;0.00541)|Epithelial(262;0.0441)		CTCACCGGGCCGGCTGCGGCT	0.706	Colon(74;686 1235 3793 23366 48562)		NA											7	5					0	0	0.00308	0	0
ZNF473	25888	broad.mit.edu	37	19	50548237	50548237	+	Silent	SNP	A	A	T	rs142027756		TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr19:50548237A>T	uc002prn.2	+	5	774	c.537A>T	c.(535-537)ACA>ACT	p.T179T	ZNF473_uc002prm.2_Silent_p.T179T|ZNF473_uc010ybo.1_Silent_p.T167T	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	179					histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		AGACCCTCACACCAGCTAAGT	0.458			NA											13	69					0	0	0.003163	0	0
NLRP5	126206	broad.mit.edu	37	19	56539579	56539579	+	Silent	SNP	G	G	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr19:56539579G>C	uc002qmj.2	+	7	1980	c.1980G>C	c.(1978-1980)GGG>GGC	p.G660G	NLRP5_uc002qmi.2_Silent_p.G641G	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	660						mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TTCCCCTGGGGGTGAAGCAGA	0.577			NA											11	89					0	0	0.013537	0	0
ZNF304	57343	broad.mit.edu	37	19	57869098	57869098	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr19:57869098G>C	uc010ygw.1	+	3	2249	c.1861G>C	c.(1861-1863)GGG>CGG	p.G621R	ZNF304_uc010etw.2_Missense_Mutation_p.G668R|ZNF304_uc010etx.2_Missense_Mutation_p.G579R	NM_020657	NP_065708	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	621	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		CAGCGAATGTGGGAAAGCCTA	0.502			NA											23	114					0	0	0.012319	0	0
DNMT3A	1788	broad.mit.edu	37	2	25470495	25470495	+	Missense_Mutation	SNP	A	A	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr2:25470495A>C	uc002rgc.2	-	8	1236	c.979T>G	c.(979-981)TGG>GGG	p.W327G	DNMT3A_uc002rgd.2_Missense_Mutation_p.W327G|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.W138G	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	327	Interaction with DNMT1 and DNMT3B.|PWWP.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACATGACCCAGCGGGTGCCT	0.622			NA	Mis|F|N|S		AML								16	53					0	0	0.00499	0	0
DNAH6	1768	broad.mit.edu	37	2	84804447	84804447	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr2:84804447G>C	uc010fgb.2	+	13	2128	c.1991G>C	c.(1990-1992)AGA>ACA	p.R664T	DNAH6_uc002soo.2_Missense_Mutation_p.R243T|DNAH6_uc002sop.2_Missense_Mutation_p.R243T	NM_001370	NP_001361	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy polypeptide 6	664	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			central_nervous_system(1)	1						GTAGCGCTCAGACCCACCAGA	0.343			NA											12	40					0	0	0.016723	0	0
DDX11L2	84771	broad.mit.edu	37	2	114357557	114357557	+	Nonstop_Mutation	SNP	A	A	G	rs115341812	by1000genomes	TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr2:114357557A>G	uc010yxx.1	-	3	709	c.382T>C	c.(382-384)TAG>CAG	p.*128Q						SubName: Full=DEAD/H box polypeptide 11 like 2;												0						GCCTACTTCTAGTGAAACTGG	0.567			NA											3	25					0	0	0.004672	0	0
GLI2	2736	broad.mit.edu	37	2	121708991	121708991	+	Missense_Mutation	SNP	T	T	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr2:121708991T>A	uc010flp.2	+	3	457	c.427T>A	c.(427-429)TCT>ACT	p.S143T	GLI2_uc010yyu.1_Missense_Mutation_p.S143T|GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Intron|GLI2_uc002tmu.3_Intron|GLI2_uc002tmv.1_Intron|GLI2_uc010flo.1_Missense_Mutation_p.S18T|GLI2_uc002tmw.1_Missense_Mutation_p.S143T	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	143					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				CTCCATGATCTCTGCAGCCAG	0.677			NA											11	42					0	0	0.008291	0	0
LRP1B	53353	broad.mit.edu	37	2	141526893	141526893	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr2:141526893A>G	uc002tvj.1	-	35	6619	c.5647T>C	c.(5647-5649)TAC>CAC	p.Y1883H		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1883	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGAACAGAGTACATAAGAAAT	0.383	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			11	32					0	0	0.016723	0	0
CDCA7	83879	broad.mit.edu	37	2	174229553	174229553	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr2:174229553C>T	uc002uid.1	+	5	624	c.493C>T	c.(493-495)CCG>TCG	p.P165S	CDCA7_uc002uic.1_Missense_Mutation_p.P244S|CDCA7_uc010zej.1_Missense_Mutation_p.P200S|CDCA7_uc010zek.1_Missense_Mutation_p.P123S	NM_145810	NP_665809	Q9BWT1	CDCA7_HUMAN	cell division cycle associated 7 isoform 2	165	Arg-rich.				regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.116)			GCGTACATTCCCGGGTGTTGC	0.498			NA											16	65					0	0	0.007413	0	0
TTN	7273	broad.mit.edu	37	2	179446303	179446303	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr2:179446303C>G	uc010zfg.1	-	265	59212	c.58988G>C	c.(58987-58989)CGT>CCT	p.R19663P	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R13358P|TTN_uc010zfi.1_Missense_Mutation_p.R13291P|TTN_uc010zfj.1_Missense_Mutation_p.R13166P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20590							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCATACACACGGAATTGATA	0.453			NA											13	52					0	0	0.016723	0	0
ABCA12	26154	broad.mit.edu	37	2	215884116	215884116	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr2:215884116G>C	uc002vew.2	-	13	1821	c.1601C>G	c.(1600-1602)CCG>CGG	p.P534R	ABCA12_uc002vev.2_Missense_Mutation_p.P216R|ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	534					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TTCTATGATCGGTATTAACTG	0.358	Ovarian(66;664 1488 5121 34295)		NA											12	59					0	0	0.013537	0	0
GMEB2	26205	broad.mit.edu	37	20	62234350	62234350	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr20:62234350C>G	uc002yfp.1	-	3	804	c.325G>C	c.(325-327)GTG>CTG	p.V109L	GMEB2_uc002yfo.1_Missense_Mutation_p.V31L|GMEB2_uc002yfq.1_Missense_Mutation_p.V109L	NM_012384	NP_036516	Q9UKD1	GMEB2_HUMAN	glucocorticoid modulatory element binding	109	SAND.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|metal ion binding				0	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;4.79e-09)|all cancers(9;2.76e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.0114)			CCGGGACACACAAACTTCCTC	0.547			NA											4	116					0	0	0.014758	0	0
ZGPAT	84619	broad.mit.edu	37	20	62364617	62364617	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr20:62364617C>T	uc002ygk.2	+	3	809	c.631C>T	c.(631-633)CAG>TAG	p.Q211*	ZGPAT_uc002ygi.2_Nonsense_Mutation_p.Q211*|ZGPAT_uc002ygj.2_Nonsense_Mutation_p.Q211*|ZGPAT_uc010gkk.1_Intron|ZGPAT_uc010gkl.1_Nonsense_Mutation_p.Q211*|ZGPAT_uc002ygm.2_Nonsense_Mutation_p.Q211*|ZGPAT_uc002ygn.3_RNA|LIME1_uc011abi.1_5'Flank	NM_032527	NP_115916	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	211					negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					GCGCCCCTTCCAGGACCCAGA	0.667			NA											4	45					0	0	0.014758	0	0
NRIP1	8204	broad.mit.edu	37	21	16338607	16338607	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr21:16338607T>C	uc002yjx.2	-	4	2505	c.1907A>G	c.(1906-1908)CAA>CGA	p.Q636R		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	636	Repression domain 2.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		CATTCCACATTGTGCTAAATT	0.428			NA											8	130					0	0	0.004482	0	0
GTPBP1	9567	broad.mit.edu	37	22	39112766	39112766	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr22:39112766C>T	uc003awg.2	+	4	749	c.595C>T	c.(595-597)CAC>TAC	p.H199Y		NM_004286	NP_004277	O00178	GTPB1_HUMAN	GTP binding protein 1	199					immune response|positive regulation of mRNA catabolic process|signal transduction	cytoplasmic exosome (RNase complex)|cytosol	GTP binding|GTPase activity			ovary(1)	1	Melanoma(58;0.04)					ACTCTTCCGCCACAAACATGA	0.562			NA											12	58					0	0	0.016723	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50660468	50660468	+	Missense_Mutation	SNP	C	C	A	rs143355923		TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr22:50660468C>A	uc003bkb.1	-	15	2985	c.2473G>T	c.(2473-2475)GTG>TTG	p.V825L	TUBGCP6_uc003bka.1_5'Flank|TUBGCP6_uc010har.1_Missense_Mutation_p.V817L|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hat.1_Missense_Mutation_p.V21L	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	825					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TGGGGGTGCACGCTCAAGAGG	0.607			NA											10	63					3.27435e-08	4.01045e-08	0.020292	1	0
LIMD1	8994	broad.mit.edu	37	3	45637520	45637520	+	Silent	SNP	C	C	G			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr3:45637520C>G	uc003coq.2	+	1	1198	c.1149C>G	c.(1147-1149)CTC>CTG	p.L383L		NM_014240	NP_055055	Q9UGP4	LIMD1_HUMAN	LIM domains containing 1	383					cytoplasmic mRNA processing body assembly|gene silencing by miRNA|multicellular organismal development|negative regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasmic mRNA processing body|nucleus|RNA-induced silencing complex	protein binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.011)|KIRC - Kidney renal clear cell carcinoma(197;0.0264)|Kidney(197;0.0315)		GTCCCAAGCTCAGCCCCACCA	0.617			NA											4	27					0	0	0.009096	0	0
ROBO1	6091	broad.mit.edu	37	3	78649390	78649390	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr3:78649390C>T	uc003dqe.2	-	30	5022	c.4814G>A	c.(4813-4815)AGC>AAC	p.S1605N	ROBO1_uc003dqb.2_Missense_Mutation_p.S1566N|ROBO1_uc003dqc.2_Missense_Mutation_p.S1505N|ROBO1_uc003dqd.2_Missense_Mutation_p.S1560N|ROBO1_uc010hoh.2_Missense_Mutation_p.S797N	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1605	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TGACATTGAGCTTGAGGAACT	0.378			NA											8	81					0	0	0.004482	0	0
TOMM70A	9868	broad.mit.edu	37	3	100093992	100093992	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr3:100093992C>T	uc003dtw.2	-	7	1529	c.1097G>A	c.(1096-1098)CGA>CAA	p.R366Q		NM_014820	NP_055635	O94826	TOM70_HUMAN	translocase of outer mitochondrial membrane 70	366	Cytoplasmic (Potential).				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			ovary(1)	1						AGCATTTGCTCGAAGCTATAT	0.353			NA											7	142					0	0	0.001984	0	0
PLSCR2	57047	broad.mit.edu	37	3	146166994	146166994	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr3:146166994A>G	uc003evv.1	-	7	977	c.644T>C	c.(643-645)ATT>ACT	p.I215T	PLSCR2_uc003evw.1_Missense_Mutation_p.I284T	NM_020359	NP_065092	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	215	Helical; (Potential).				phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity				0						TAGACTTACAATGAGGAAACA	0.353			NA											8	93					0	0	0.004482	0	0
PLSCR2	57047	broad.mit.edu	37	3	146167007	146167007	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr3:146167007C>G	uc003evv.1	-	7	964	c.631G>C	c.(631-633)GCC>CCC	p.A211P	PLSCR2_uc003evw.1_Missense_Mutation_p.A280P	NM_020359	NP_065092	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	211	Helical; (Potential).				phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity				0						AGGAAACAGGCACCAATCATC	0.368			NA											11	106					0	0	0.008291	0	0
PHC3	80012	broad.mit.edu	37	3	169840403	169840403	+	Missense_Mutation	SNP	A	A	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr3:169840403A>C	uc010hws.1	-	9	1946	c.1882T>G	c.(1882-1884)TTG>GTG	p.L628V	PHC3_uc003fgl.2_Missense_Mutation_p.L640V|PHC3_uc011bpq.1_Missense_Mutation_p.L587V	NM_024947	NP_079223	Q8NDX5	PHC3_HUMAN	polyhomeotic like 3	628	Pro-rich.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			TCAGAAGTCAAATCTTCTCCT	0.388			NA											15	80					0	0	0.006122	0	0
TTC14	151613	broad.mit.edu	37	3	180327734	180327734	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr3:180327734G>A	uc003fkk.2	+	12	1849	c.1717G>A	c.(1717-1719)GAG>AAG	p.E573K	TTC14_uc003fkl.2_3'UTR|TTC14_uc003fkm.2_Missense_Mutation_p.E573K	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	573							RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			ACAGATAAAAGAGAAAGATAG	0.373			NA											31	265					0	0	0.015359	0	0
POLR2H	5437	broad.mit.edu	37	3	184081293	184081293	+	Silent	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr3:184081293C>T	uc003fok.1	+	1	100	c.13C>T	c.(13-15)CTG>TTG	p.L5L	CLCN2_uc003foi.2_5'Flank|CLCN2_uc010hya.1_5'Flank|CLCN2_uc011brl.1_5'Flank|CLCN2_uc011brm.1_5'Flank|CLCN2_uc011brn.1_5'Flank|POLR2H_uc003foj.1_RNA	NM_006232	NP_006223	P52434	RPAB3_HUMAN	RNA polymerase II, polypeptide H	5					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex|nucleolus	DNA-directed RNA polymerase activity|protein binding|zinc ion binding				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGCGGGCATCCTGTTTGAGGA	0.572			NA									OREG0015950	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	91					0	0	0.003163	0	0
ACOX3	8310	broad.mit.edu	37	4	8407736	8407736	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr4:8407736C>T	uc010idk.2	-	7	867	c.722G>A	c.(721-723)GGA>GAA	p.G241E	ACOX3_uc003glc.3_Missense_Mutation_p.G241E|ACOX3_uc003gld.3_Missense_Mutation_p.G241E|ACOX3_uc003gle.1_Missense_Mutation_p.G146E	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	241					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						AACCATCACTCCAGGCATGGG	0.498			NA											32	280					0	0	0.019004	0	0
GRXCR1	389207	broad.mit.edu	37	4	42895466	42895466	+	Silent	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr4:42895466G>A	uc003gwt.2	+	1	183	c.183G>A	c.(181-183)CAG>CAA	p.Q61Q		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	61					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						CCGATGGACAGCAGAATGGCC	0.483			NA											5	284					0	0	0.014758	0	0
LRRC66	339977	broad.mit.edu	37	4	52860582	52860582	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr4:52860582G>T	uc003gzi.2	-	4	2619	c.2606C>A	c.(2605-2607)GCT>GAT	p.A869D		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	869						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						ATGGAAGGCAGCCTTATCAGG	0.373			NA											4	57					1.23904e-05	1.45014e-05	0.014758	1	0
TMPRSS11D	9407	broad.mit.edu	37	4	68691511	68691511	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr4:68691511C>T	uc003hdq.2	-	9	1099	c.1034G>A	c.(1033-1035)GGA>GAA	p.G345E	LOC550112_uc003hdl.3_Intron|TMPRSS11D_uc003hdp.2_Missense_Mutation_p.G126E|TMPRSS11D_uc011caj.1_Missense_Mutation_p.G228E	NM_004262	NP_004253	O60235	TM11D_HUMAN	transmembrane protease, serine 11D	345	Peptidase S1.|Extracellular (Potential).				proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						CAAGATGGCTCCATTATAACT	0.438			NA											4	70					0	0	0.009096	0	0
AGXT2L1	64850	broad.mit.edu	37	4	109665008	109665008	+	Missense_Mutation	SNP	T	T	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr4:109665008T>A	uc003hzc.2	-	12	1489	c.1308A>T	c.(1306-1308)TTA>TTT	p.L436F	AGXT2L1_uc010imc.2_Missense_Mutation_p.L430F|AGXT2L1_uc011cfm.1_Missense_Mutation_p.L396F|AGXT2L1_uc011cfn.1_Missense_Mutation_p.L363F|AGXT2L1_uc011cfo.1_Missense_Mutation_p.L378F	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1	436					cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		TAGCTTCTTCTAAAACTGAAT	0.338			NA											6	57					0	0	0.001984	0	0
ZNF827	152485	broad.mit.edu	37	4	146791527	146791527	+	Silent	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr4:146791527G>A	uc003ikn.2	-	5	1899	c.1851C>T	c.(1849-1851)TTC>TTT	p.F617F	ZNF827_uc003ikm.2_Silent_p.F617F|ZNF827_uc010iox.2_Silent_p.F267F	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	617					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					ATTCCGGGCTGAACACATAGC	0.522			NA											7	104					0	0	0.004482	0	0
ARHGAP10	79658	broad.mit.edu	37	4	148796218	148796218	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr4:148796218T>C	uc003ilf.2	+	8	749	c.749T>C	c.(748-750)ATG>ACG	p.M250T		NM_024605	NP_078881	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	250	BAR.				apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			skin(2)|pancreas(1)|lung(1)	4	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		GAAGAGCTCATGAACAAAATC	0.418			NA											3	31					0	0	0.004672	0	0
FRG1	2483	broad.mit.edu	37	4	190878596	190878596	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr4:190878596G>A	uc003izs.2	+	6	667	c.476G>A	c.(475-477)TGC>TAC	p.C159Y		NM_004477	NP_004468	Q14331	FRG1_HUMAN	FSHD region gene 1	159					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus					0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		TTTATTAGATGCAATGAAGCA	0.368			NA											3	21					0	0	0.014758	0	0
PARP8	79668	broad.mit.edu	37	5	50111358	50111358	+	Silent	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr5:50111358G>A	uc003jon.3	+	16	1850	c.1668G>A	c.(1666-1668)CAG>CAA	p.Q556Q	PARP8_uc011cpz.1_Silent_p.Q448Q|PARP8_uc003joo.2_Silent_p.Q556Q|PARP8_uc003jop.2_Silent_p.Q556Q	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	556						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				CTGGAGCTCAGGTAGTAACAC	0.378			NA											3	37					0	0	0.004672	0	0
ACSL6	23305	broad.mit.edu	37	5	131309043	131309043	+	Silent	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr5:131309043G>A	uc010jdo.1	-	12	1127	c.1044C>T	c.(1042-1044)ATC>ATT	p.I348I	ACSL6_uc003kvv.1_RNA|ACSL6_uc003kvx.1_Silent_p.I373I|ACSL6_uc003kvy.1_Silent_p.I373I|ACSL6_uc003kwb.2_Silent_p.I338I|ACSL6_uc003kvz.1_Silent_p.I273I|ACSL6_uc003kwa.1_Silent_p.I359I|ACSL6_uc003kvw.1_5'UTR|ACSL6_uc010jdn.1_Silent_p.I363I|ACSL6_uc010jdp.1_RNA	NM_015256	NP_056071	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	348	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGAGAAGGCGGATATCTCCCT	0.547			NA											6	35					0	0	0.001984	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208743	140208743	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr5:140208743C>T	uc003lho.2	+	1	1094	c.1067C>T	c.(1066-1068)TCC>TTC	p.S356F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Missense_Mutation_p.S356F|PCDHA6_uc011dab.1_Missense_Mutation_p.S356F	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	356	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTTCCTTATCCTTGCCTGTA	0.498			NA											9	150					0	0	0.020292	0	0
HIST1H1E	3008	broad.mit.edu	37	6	26156807	26156807	+	Silent	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr6:26156807G>A	uc003ngq.2	+	1	249	c.189G>A	c.(187-189)AAG>AAA	p.K63K	HIST1H2BD_uc003ngr.2_5'Flank|HIST1H2BD_uc003ngs.2_5'Flank	NM_005321	NP_005312	P10412	H14_HUMAN	histone cluster 1, H1e	63	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			large_intestine(1)|ovary(1)	2						CCGCTCTCAAGAAAGCGCTGG	0.617			NA											7	59					0	0	0.001984	0	0
C6orf136	221545	broad.mit.edu	37	6	30619243	30619243	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr6:30619243G>A	uc003nqw.3	+	4	957	c.764G>A	c.(763-765)CGG>CAG	p.R255Q	C6orf136_uc003nqx.3_Missense_Mutation_p.R436Q|C6orf136_uc011dmn.1_Missense_Mutation_p.R121Q	NM_001109938	NP_001103408	Q5SQH8	CF136_HUMAN	hypothetical protein LOC221545 isoform 1	255											0						GAGCATTACCGGTAAGAGAGA	0.368			NA											4	198					0	0	0.009096	0	0
GSTA1	2938	broad.mit.edu	37	6	52657701	52657701	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr6:52657701C>T	uc003paz.2	-	6	611	c.499G>A	c.(499-501)GTC>ATC	p.V167I		NM_145740	NP_665683	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1	167	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	AGCTCCTCGACGTAGTAGAGA	0.532			NA											13	211					0	0	0.013537	0	0
C6orf204	387119	broad.mit.edu	37	6	118887202	118887202	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr6:118887202C>A	uc003pxz.1	-	3	1098	c.510G>T	c.(508-510)CAG>CAT	p.Q170H	C6orf204_uc003pya.1_Missense_Mutation_p.Q173H|C6orf204_uc003pyb.2_Missense_Mutation_p.Q170H|C6orf204_uc011ebj.1_Missense_Mutation_p.Q68H|C6orf204_uc003pyc.2_Missense_Mutation_p.Q173H|C6orf204_uc011ebl.1_Missense_Mutation_p.Q68H	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	170						centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		CAGTGCCACCCTGGCCACAGT	0.507			NA											10	77					3.86212e-05	4.42185e-05	0.008291	1	0
NCOA7	135112	broad.mit.edu	37	6	126249904	126249904	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr6:126249904G>C	uc010kes.2	+	18	3265	c.2816G>C	c.(2815-2817)TGG>TCG	p.W939S	NCOA7_uc003qae.3_Missense_Mutation_p.W939S|NCOA7_uc003qah.2_Missense_Mutation_p.W928S|NCOA7_uc003qai.2_Missense_Mutation_p.W939S|NCOA7_uc010ket.2_Missense_Mutation_p.W824S|NCOA7_uc003qak.2_Missense_Mutation_p.W216S	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	939	TLD.				cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		CTGGAGGTGTGGGCATTTGAT	0.418			NA											17	64					0	0	0.006122	0	0
GRM1	2911	broad.mit.edu	37	6	146755808	146755808	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr6:146755808C>T	uc010khw.1	+	9	3931	c.3461C>T	c.(3460-3462)TCG>TTG	p.S1154L	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	1154	Ser-rich.|Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TTCCGCGACTCGGTGGCCTCG	0.657			NA											8	61					0	0	0.004482	0	0
AKAP12	9590	broad.mit.edu	37	6	151670666	151670666	+	Silent	SNP	C	C	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr6:151670666C>A	uc011eep.1	+	4	1380	c.1140C>A	c.(1138-1140)CCC>CCA	p.P380P	AKAP12_uc003qoe.2_Silent_p.P380P|AKAP12_uc003qof.2_Silent_p.P282P|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Silent_p.P275P	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	380	Involved in PKC-binding (Probable).				G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		TTGAGCTGCCCTCAGAGGAGC	0.552	Melanoma(141;1616 1805 10049 24534 51979)		NA											4	57					0.000602214	0.000660763	0.014758	1	0
CCR6	1235	broad.mit.edu	37	6	167550481	167550481	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr6:167550481G>C	uc003qvl.2	+	13	3239	c.763G>C	c.(763-765)GTA>CTA	p.V255L	CCR6_uc010kkm.2_Missense_Mutation_p.V255L|CCR6_uc003qvn.3_Missense_Mutation_p.V255L|CCR6_uc003qvm.3_Missense_Mutation_p.V255L	NM_031409	NP_113597	P51684	CCR6_HUMAN	chemokine (C-C motif) receptor 6	255	Helical; Name=6; (Potential).				cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|humoral immune response	integral to plasma membrane	C-C chemokine receptor activity			ovary(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;8.21e-20)|BRCA - Breast invasive adenocarcinoma(81;4.55e-06)|GBM - Glioblastoma multiforme(31;0.00507)		AGCCATCCGTGTAATCATAGC	0.418			NA											5	71					0	0	0.014758	0	0
TXNDC3	51314	broad.mit.edu	37	7	37916489	37916489	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr7:37916489G>A	uc003tfn.2	+	12	1246	c.874G>A	c.(874-876)GAT>AAT	p.D292N		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	292					cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						CATTGAAGAGGATGCAGCTAA	0.323	Ovarian(108;903 1537 27096 29907 47400)		NA							Kartagener_syndrome				3	36					0	0	0.004672	0	0
EGFR	1956	broad.mit.edu	37	7	55241708	55241708	+	Missense_Mutation	SNP	G	G	C	rs121913428		TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr7:55241708G>C	uc003tqk.2	+	18	2402	c.2156G>C	c.(2155-2157)GGC>GCC	p.G719A	EGFR_uc010kzg.1_Missense_Mutation_p.G674A|EGFR_uc011kco.1_Missense_Mutation_p.G666A	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	719	Cytoplasmic (Potential).|Protein kinase.|ATP.		G -> A (found in a lung cancer sample).|G -> D (found in a lung cancer sample).|G -> S (found in a lung cancer sample; somatic mutation; strongly increased kinase activity).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.G719S(61)|p.G719A(52)|p.G719C(31)|p.G719?(9)|p.G719D(6)|p.G719V(1)|p.G719fs*29(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AAAGTGCTGGGCTCCGGTGCG	0.582			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			25	60					0	0	0.01892	0	0
EGFR	1956	broad.mit.edu	37	7	55249005	55249005	+	Missense_Mutation	SNP	G	G	T	rs146024686		TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr7:55249005G>T	uc003tqk.2	+	20	2549	c.2303G>T	c.(2302-2304)AGC>ATC	p.S768I	EGFR_uc010kzg.1_Missense_Mutation_p.S723I|EGFR_uc011kco.1_Missense_Mutation_p.S715I|uc003tqo.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	768	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.S768I(53)|p.S768_V769insAWT(1)|p.S768N(1)|p.S752_V769del(1)|p.S768_V769insVAS(1)|p.S768C(1)|p.S768_V769>IL(1)|p.A767_S768insTLA(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GTGATGGCCAGCGTGGACAAC	0.637			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			36	105					1.58521e-26	2.03628e-26	0.005524	1	0
GTF2IRD1	9569	broad.mit.edu	37	7	73973268	73973268	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr7:73973268G>A	uc003uaq.2	+	21	2623	c.2230G>A	c.(2230-2232)GAG>AAG	p.E744K	GTF2IRD1_uc010lbq.2_Missense_Mutation_p.E761K|GTF2IRD1_uc003uap.2_Missense_Mutation_p.E729K|GTF2IRD1_uc003uar.1_Missense_Mutation_p.E729K	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	744	GTF2I-like 4.					nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						CGTGATCATCGAGGGGCTGCC	0.597			NA											4	60					0	0	0.009096	0	0
ABCB4	5244	broad.mit.edu	37	7	87041236	87041236	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr7:87041236C>G	uc003uiv.1	-	23	2973	c.2897G>C	c.(2896-2898)GGA>GCA	p.G966A	ABCB4_uc003uiw.1_Missense_Mutation_p.G966A|ABCB4_uc003uix.1_Intron	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	966	Extracellular (By similarity).|ABC transmembrane type-1 2.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GCGCATATGTCCATTCACAAT	0.318			NA											3	32					0	0	0.004672	0	0
PRSS1	5644	broad.mit.edu	37	7	142459867	142459867	+	Missense_Mutation	SNP	C	C	A	rs149770610		TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr7:142459867C>A	uc003wak.2	+	3	460	c.443C>A	c.(442-444)GCG>GAG	p.A148E	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc003wam.2_Missense_Mutation_p.A88E	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	148	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			GGCAACACTGCGAGCTCTGGC	0.577			NA							Hereditary_Pancreatitis				4	106					0.00024832	0.0002763	0.009096	1	0
SLC7A2	6542	broad.mit.edu	37	8	17421114	17421114	+	Silent	SNP	T	T	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr8:17421114T>C	uc011kyc.1	+	11	1843	c.1674T>C	c.(1672-1674)GTT>GTC	p.V558V	SLC7A2_uc011kyd.1_Silent_p.V597V|SLC7A2_uc011kye.1_Silent_p.V598V|SLC7A2_uc011kyf.1_Silent_p.V558V	NM_001008539	NP_001008539	P52569	CTR2_HUMAN	solute carrier family 7, member 2 isoform 2	558	Helical; (Potential).				cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			ovary(2)|skin(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	CCCCTCAGGTTCCATTCTTAC	0.393			NA											6	117					0	0	0.001168	0	0
ZBTB10	65986	broad.mit.edu	37	8	81426206	81426206	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr8:81426206G>T	uc003ybx.3	+	3	2521	c.1923G>T	c.(1921-1923)TTG>TTT	p.L641F	ZBTB10_uc003ybv.3_Missense_Mutation_p.L349F|ZBTB10_uc003ybw.3_Missense_Mutation_p.L641F|ZBTB10_uc010lzt.2_Missense_Mutation_p.L639F	NM_001105539	NP_001099009	Q96DT7	ZBT10_HUMAN	zinc finger and BTB domain containing 10 isoform	641					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)	1	all_cancers(3;1.68e-09)|all_epithelial(4;5.13e-11)|Lung NSC(7;1.75e-07)|all_lung(9;7.38e-07)|Breast(3;2.96e-06)		BRCA - Breast invasive adenocarcinoma(6;0.000434)|Epithelial(68;0.00486)|all cancers(69;0.0296)			CAAATTTATTGGCTGAAGCTG	0.398			NA											7	37					0.000157383	0.000177618	0.00308	1	0
CA1	759	broad.mit.edu	37	8	86242016	86242016	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr8:86242016C>G	uc003ydh.2	-	8	771	c.571G>C	c.(571-573)GAT>CAT	p.D191H	CA13_uc003ydf.1_Intron|CA1_uc010mae.1_Missense_Mutation_p.D191H|CA1_uc003ydi.2_Missense_Mutation_p.D191H	NM_001738	NP_001729	P00915	CAH1_HUMAN	carbonic anhydrase I	191					one-carbon metabolic process	Golgi apparatus	carbonate dehydratase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(136;4.89e-06)			Acetazolamide(DB00819)|Amlodipine(DB00381)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dichlorphenamide(DB01144)|Ethinamate(DB01031)|Ethoxzolamide(DB00311)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Levetiracetam(DB01202)|Methazolamide(DB00703)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)|Verapamil(DB00661)|Zonisamide(DB00909)	GTCCAGAAATCCAGGGATGAA	0.448			NA											3	14					0	0	0.004672	0	0
SLC26A7	115111	broad.mit.edu	37	8	92374658	92374658	+	Silent	SNP	C	C	T	rs144974209		TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr8:92374658C>T	uc003yex.2	+	13	1670	c.1392C>T	c.(1390-1392)ACC>ACT	p.T464T	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Silent_p.T464T|SLC26A7_uc003yfa.2_Silent_p.T464T	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	464	Helical; (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			TTGTTTGTACCATAGCTATAG	0.393			NA											6	148					0	0	0.001984	0	0
TG	7038	broad.mit.edu	37	8	134042186	134042186	+	Missense_Mutation	SNP	G	G	A	rs144905796	byFrequency	TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr8:134042186G>A	uc003ytw.2	+	41	7198	c.7157G>A	c.(7156-7158)CGT>CAT	p.R2386H	TG_uc010mdw.2_Missense_Mutation_p.R1145H|TG_uc011ljb.1_Missense_Mutation_p.R755H|TG_uc011ljc.1_Missense_Mutation_p.R519H	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2386					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GCAGCAGACCGTGGCGGGGCT	0.642			NA											5	60					0	0	0.001168	0	0
TEX10	54881	broad.mit.edu	37	9	103108428	103108428	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr9:103108428C>T	uc004bas.2	-	4	1278	c.1063G>A	c.(1063-1065)GTT>ATT	p.V355I	TEX10_uc011lvf.1_Missense_Mutation_p.V194I|TEX10_uc011lvg.1_Missense_Mutation_p.V358I|TEX10_uc011lvh.1_Missense_Mutation_p.V290I|TEX10_uc004bat.2_Missense_Mutation_p.V355I	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	355						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		TGCTGCATAACCTGTAGAGGT	0.378			NA											19	39					0	0	0.007413	0	0
C9orf125	84302	broad.mit.edu	37	9	104238192	104238192	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr9:104238192G>A	uc004bbm.2	-	2	1505	c.1183C>T	c.(1183-1185)CGG>TGG	p.R395W	uc004bbl.1_5'Flank	NM_032342	NP_115718	Q9BRR3	CI125_HUMAN	hypothetical protein LOC84302	395						integral to membrane					0		Acute lymphoblastic leukemia(62;0.0527)				AAGTTGTACCGGAGACTGGAG	0.488			NA											28	114					0	0	0.015359	0	0
TLR4	7099	broad.mit.edu	37	9	120476638	120476638	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr9:120476638C>A	uc004bjz.2	+	3	2523	c.2232C>A	c.(2230-2232)AGC>AGA	p.S744R	TLR4_uc004bka.2_Missense_Mutation_p.S704R|TLR4_uc004bkb.2_Missense_Mutation_p.S544R	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	744	Cytoplasmic (Potential).|TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TCATCCAGAGCCGCTGGTGTA	0.488			NA											29	45					5.60225e-13	7.08124e-13	0.009535	1	0
ODF2	4957	broad.mit.edu	37	9	131219701	131219701	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr9:131219701C>T	uc011mbd.1	+	2	328	c.17C>T	c.(16-18)TCA>TTA	p.S6L	ODF2_uc011maz.1_Intron|ODF2_uc011mba.1_Intron|ODF2_uc010myb.2_Intron|ODF2_uc011mbb.1_Intron|ODF2_uc011mbc.1_Intron|ODF2_uc004bva.2_Intron|ODF2_uc004bvb.2_5'UTR|ODF2_uc011mbe.1_Intron|ODF2_uc004bvc.2_Intron|ODF2_uc010myc.2_Intron|ODF2_uc011mbf.1_Intron|ODF2_uc004bvd.3_Missense_Mutation_p.S6L|ODF2_uc004bve.2_Missense_Mutation_p.S6L	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	6					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						GCCTCATCCTCAGGCGGCTCC	0.657			NA											6	117					0	0	0.004482	0	0
ODF2	4957	broad.mit.edu	37	9	131223324	131223324	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr9:131223324G>T	uc011mbd.1	+	4	538	c.227G>T	c.(226-228)CGG>CTG	p.R76L	ODF2_uc011maz.1_Missense_Mutation_p.R76L|ODF2_uc011mba.1_5'UTR|ODF2_uc010myb.2_Intron|ODF2_uc011mbb.1_Intron|ODF2_uc011mbc.1_Intron|ODF2_uc004bva.2_Missense_Mutation_p.R29L|ODF2_uc004bvb.2_Intron|ODF2_uc011mbe.1_Missense_Mutation_p.R71L|ODF2_uc004bvc.2_Intron|ODF2_uc010myc.2_Missense_Mutation_p.R76L|ODF2_uc011mbf.1_Intron|ODF2_uc004bvd.3_Missense_Mutation_p.R76L|ODF2_uc004bve.2_Intron	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	76					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						TCATCTGCCCGGCCTGTGGGA	0.572			NA											16	28					6.31663e-08	7.61853e-08	0.003163	1	0
GPR34	2857	broad.mit.edu	37	X	41555240	41555240	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chrX:41555240C>G	uc004dfp.3	+	3	638	c.354C>G	c.(352-354)AAC>AAG	p.N118K	CASK_uc004dfl.3_Intron|CASK_uc004dfm.3_Intron|CASK_uc004dfn.3_Intron|GPR34_uc004dfq.3_Missense_Mutation_p.N118K|GPR34_uc010nhg.2_Missense_Mutation_p.N118K|GPR34_uc004dfr.3_Missense_Mutation_p.N118K	NM_001097579	NP_001091048	Q9UPC5	GPR34_HUMAN	G protein-coupled receptor 34	118	Extracellular (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1						TTAACCAAAACAAGTGGACAC	0.368			NA											9	212					0	0	0.006214	0	0
RP2	6102	broad.mit.edu	37	X	46713257	46713257	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chrX:46713257G>A	uc004dgw.3	+	2	638	c.449G>A	c.(448-450)TGG>TAG	p.W150*		NM_006915	NP_008846	O75695	XRP2_HUMAN	XRP2 protein	150	C-CAP/cofactor C-like.				cell morphogenesis|CTP biosynthetic process|GTP biosynthetic process|protein folding|UTP biosynthetic process|visual perception	cytoplasm|plasma membrane	ATP binding|GTP binding|GTPase activator activity|nucleoside diphosphate kinase activity|unfolded protein binding				0						TGTTTTCAATGGTACTATCCT	0.388			NA											6	76					0	0	0.001168	0	0
HUWE1	10075	broad.mit.edu	37	X	53672299	53672299	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chrX:53672299C>G	uc004dsp.2	-	7	870	c.468G>C	c.(466-468)AGG>AGC	p.R156S		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	156					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GCAGCGGGGTCCTCTTGTCAG	0.473			NA											4	82					0	0	0.009096	0	0
TEX11	56159	broad.mit.edu	37	X	69960640	69960640	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chrX:69960640C>T	uc004dyl.2	-	12	961	c.799G>A	c.(799-801)GTT>ATT	p.V267I	TEX11_uc004dym.2_Missense_Mutation_p.V252I	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	267							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					AGCCGTAGAACTTTAGCCTGT	0.383			NA											3	30					0	0	0.004672	0	0
ATRX	546	broad.mit.edu	37	X	76937732	76937732	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chrX:76937732C>T	uc004ecp.3	-	9	3248	c.3016G>A	c.(3016-3018)GAA>AAA	p.E1006K	ATRX_uc004ecq.3_Missense_Mutation_p.E968K|ATRX_uc004eco.3_Missense_Mutation_p.E791K|ATRX_uc004ecr.2_Missense_Mutation_p.E938K|ATRX_uc010nlx.1_Missense_Mutation_p.E977K|ATRX_uc010nly.1_Missense_Mutation_p.E951K	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1006					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TACTGTTGTTCCATTTTAATT	0.338			NA	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						5	154					0	0	0.001984	0	0
DACH2	117154	broad.mit.edu	37	X	86067912	86067912	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chrX:86067912C>A	uc004eew.2	+	8	1464	c.1294C>A	c.(1294-1296)CTG>ATG	p.L432M	DACH2_uc004eex.2_Missense_Mutation_p.L419M|DACH2_uc010nmq.2_Missense_Mutation_p.L298M|DACH2_uc011mra.1_Missense_Mutation_p.L265M|DACH2_uc010nmr.2_Missense_Mutation_p.L213M|DACH2_uc004eey.2_Missense_Mutation_p.L115M|DACH2_uc004eez.2_Missense_Mutation_p.L115M	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	432					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						CAAGATACAGCTGACTCCTGG	0.448			NA											3	26					0.000602214	0.000660763	0.014758	1	0
DACH2	117154	broad.mit.edu	37	X	86069769	86069769	+	Missense_Mutation	SNP	G	G	T	rs143491219		TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chrX:86069769G>T	uc004eew.2	+	10	1786	c.1616G>T	c.(1615-1617)CGC>CTC	p.R539L	DACH2_uc004eex.2_Missense_Mutation_p.R526L|DACH2_uc010nmq.2_Missense_Mutation_p.R405L|DACH2_uc011mra.1_Missense_Mutation_p.R372L|DACH2_uc010nmr.2_Missense_Mutation_p.R320L|DACH2_uc004eey.2_Missense_Mutation_p.R232L|DACH2_uc004eez.2_Missense_Mutation_p.R222L	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	539	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						GAATCAAAGCGCCGGGAGCAA	0.438			NA											5	56					5.9392e-07	7.05559e-07	0.001168	1	0
COL4A5	1287	broad.mit.edu	37	X	107802324	107802324	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chrX:107802324C>T	uc004enz.1	+	3	374	c.172C>T	c.(172-174)CAC>TAC	p.H58Y	COL4A5_uc011mso.1_Missense_Mutation_p.H58Y	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	58	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						TTTGGAAGGACACCCAGGATT	0.468			NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				5	164					0	0	0.014758	0	0
NKAP	79576	broad.mit.edu	37	X	119064115	119064115	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chrX:119064115G>C	uc004esh.2	-	8	1104	c.937C>G	c.(937-939)CTG>GTG	p.L313V	NKAP_uc004esg.2_Missense_Mutation_p.L200V	NM_024528	NP_078804	Q8N5F7	NKAP_HUMAN	NFKB activating protein	313	Necessary for interaction with HDAC3 and transcriptional repression.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			ovary(2)	2						CCAGGTAACAGAGCATGGCCA	0.378			NA											4	100					0	0	0.009096	0	0
CT47B1	643311	broad.mit.edu	37	X	120008753	120008753	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chrX:120008753C>T	uc011muc.1	-	1	1027	c.772G>A	c.(772-774)GAG>AAG	p.E258K		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	258											0						CCCTTACCCTCGGGGGCCACG	0.542			NA											9	252					0	0	0.004482	0	0
SLITRK4	139065	broad.mit.edu	37	X	142717050	142717050	+	Missense_Mutation	SNP	T	T	A			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chrX:142717050T>A	uc004fbx.2	-	2	2251	c.1875A>T	c.(1873-1875)TTA>TTT	p.L625F	SLITRK4_uc004fby.2_Missense_Mutation_p.L625F	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	625	Helical; (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TGAGGACCACTAAGATACTTA	0.483			NA											15	95					0	0	0.020292	0	0
LDHA	3939	broad.mit.edu	37	11	18427087	18427087	+	Frame_Shift_Del	DEL	A	A	-			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr11:18427087delA	uc001mok.3	+	7	1074	c.802delA	c.(802-804)AGGfs	p.R268fs	LDHA_uc010rdc.1_Frame_Shift_Del_p.R210fs|LDHA_uc009yhn.2_Frame_Shift_Del_p.R267fs|LDHA_uc009yho.2_Frame_Shift_Del_p.R95fs|LDHA_uc001mol.3_Intron|LDHA_uc010rdd.1_Frame_Shift_Del_p.R297fs	NM_005566	NP_005557	P00338	LDHA_HUMAN	lactate dehydrogenase A isoform 1	268					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity|protein binding			central_nervous_system(3)	3					NADH(DB00157)	GAAGAATCTTAGGCGGGTGCA	0.413			NA											11	127	---	---	---	---	NA	NA	NA	NA	NA
CDKN2A	1029	broad.mit.edu	37	9	21974763	21974763	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-6595-01A-12D-1855-08	TCGA-50-6595-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9913e506-fc98-467d-8601-89595d0475e8	fd324b71-23d4-4083-ae48-1d4151970714	g.chr9:21974763delG	uc003zpk.2	-	1	276	c.64delC	c.(64-66)CGGfs	p.R22fs	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Frame_Shift_Del_p.R22fs|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Intron	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	22	ANK 1.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(23)|p.R22P(1)|p.R22fs*14(1)|p.S12fs*20(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		ACCCGACCCCGGGCCGCGGCC	0.736			17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			12	56	---	---	---	---	NA	NA	NA	NA	NA
