Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PLEKHG5	57449	broad.mit.edu	37	1	6528641	6528641	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:6528641G>C	uc001ano.1	-	21	2524	c.2423C>G	c.(2422-2424)TCA>TGA	p.S808*	PLEKHG5_uc001ann.1_Nonsense_Mutation_p.S789*|PLEKHG5_uc001anq.1_Intron|PLEKHG5_uc001anp.1_Nonsense_Mutation_p.S829*|TNFRSF25_uc001ana.2_5'Flank|TNFRSF25_uc001anb.2_5'Flank|TNFRSF25_uc001anc.2_5'Flank|TNFRSF25_uc001and.2_5'Flank|TNFRSF25_uc009vlz.2_5'Flank|TNFRSF25_uc001ane.2_5'Flank|TNFRSF25_uc001anf.2_5'Flank|TNFRSF25_uc001ang.2_5'Flank|TNFRSF25_uc001anh.2_5'Flank|TNFRSF25_uc001ani.1_5'Flank|PLEKHG5_uc001anj.1_Nonsense_Mutation_p.S313*|PLEKHG5_uc009vma.1_Nonsense_Mutation_p.S592*|PLEKHG5_uc010nzr.1_Nonsense_Mutation_p.S821*|PLEKHG5_uc001ank.1_Nonsense_Mutation_p.S752*|PLEKHG5_uc009vmb.1_Nonsense_Mutation_p.S752*|PLEKHG5_uc001anl.1_Nonsense_Mutation_p.S752*|PLEKHG5_uc001anm.1_Nonsense_Mutation_p.S752*|PLEKHG5_uc001anr.1_Nonsense_Mutation_p.S15*	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	808					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		GGAGCCATCTGAGGCACTGTG	0.622			NA											3	36					0	0	0.004672	0	0
MTOR	2475	broad.mit.edu	37	1	11227550	11227550	+	Silent	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:11227550C>G	uc001asd.2	-	29	4399	c.4278G>C	c.(4276-4278)CCG>CCC	p.P1426P		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	1426	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						CCGCTGCCTCCGGCTGCTGTA	0.478			NA											7	177					0	0	0.004482	0	0
MST1P9	11223	broad.mit.edu	37	1	17085014	17085014	+	Silent	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:17085014G>A	uc010ock.1	-	11	1461	c.1461C>T	c.(1459-1461)CGC>CGT	p.R487R	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_Silent_p.R61R	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						CCCCAGCCACGCGCAGCTTGG	0.602			NA											6	80					0	0	0.001168	0	0
ALDH4A1	8659	broad.mit.edu	37	1	19209814	19209814	+	Missense_Mutation	SNP	C	C	A	rs138334153		TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:19209814C>A	uc001bbb.2	-	6	838	c.562G>T	c.(562-564)GTG>TTG	p.V188L	ALDH4A1_uc010ocu.1_Missense_Mutation_p.V128L|ALDH4A1_uc001bbc.2_Missense_Mutation_p.V188L	NM_170726	NP_733844	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4A1 isoform a precursor	188					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	CTCGGGGGCACGCTGATGGGC	0.637			NA											11	33					3.07112e-06	4.74378e-06	0.000978	1	0
SDC3	9672	broad.mit.edu	37	1	31351584	31351584	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:31351584G>A	uc001bse.2	-	2	189	c.142C>T	c.(142-144)CAG>TAG	p.Q48*	SDC3_uc001bsd.2_5'UTR	NM_014654	NP_055469	O75056	SDC3_HUMAN	syndecan 3	48	Extracellular (Potential).					integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)|Colorectal(325;0.0466)|all_neural(195;0.0966)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0197)|READ - Rectum adenocarcinoma(331;0.0649)		CGCCAGCGCTGGGCCTAGGGA	0.627			NA											4	59					0	0	0.000248	0	0
INADL	10207	broad.mit.edu	37	1	62237198	62237198	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:62237198A>G	uc001dab.2	+	6	734	c.620A>G	c.(619-621)CAA>CGA	p.Q207R	INADL_uc009waf.1_Missense_Mutation_p.Q207R|INADL_uc001daa.2_Missense_Mutation_p.Q207R|INADL_uc001dad.3_5'UTR	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	207	PDZ 1.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						GCATTATTACAACAAACCACT	0.398			NA											14	66					0	0	0.004007	0	0
PRRX1	5396	broad.mit.edu	37	1	170695400	170695400	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:170695400G>C	uc001ghf.2	+	3	504	c.457G>C	c.(457-459)GAG>CAG	p.E153Q	PRRX1_uc001ghe.2_Missense_Mutation_p.E153Q	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b	153	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CCGCAGGAATGAGAGAGCCAT	0.512			NA											5	25					0	0	0.001168	0	0
FMO3	2328	broad.mit.edu	37	1	171077331	171077331	+	Missense_Mutation	SNP	T	T	C	rs72549327		TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:171077331T>C	uc001ghi.2	+	5	707	c.596T>C	c.(595-597)ATT>ACT	p.I199T	FMO3_uc001ghh.2_Missense_Mutation_p.I199T|FMO3_uc010pmb.1_Missense_Mutation_p.I179T|FMO3_uc010pmc.1_Missense_Mutation_p.I136T	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	199					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGCTGTGATATTGCCACAGAA	0.493			NA											6	60					0	0	0.001984	0	0
TNFSF4	7292	broad.mit.edu	37	1	173155820	173155820	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:173155820C>T	uc001giw.2	-	3	543	c.387G>A	c.(385-387)CTG>CTA	p.L129L	TNFSF4_uc001giv.2_Silent_p.L79L	NM_003326	NP_003317	P23510	TNFL4_HUMAN	tumor necrosis factor (ligand) superfamily,	129	Extracellular (Potential).				acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T-helper 1 cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell proliferation|positive regulation of B cell activation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction|T-helper 2 cell activation	cell surface|extracellular space|integral to plasma membrane	cytokine activity			central_nervous_system(1)	1						TGACCTTCTTCAGTTGGAAGA	0.473			NA											11	42					0	0	0.000978	0	0
TNR	7143	broad.mit.edu	37	1	175355363	175355363	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:175355363G>A	uc001gkp.1	-	6	1663	c.1582C>T	c.(1582-1584)CGA>TGA	p.R528*	TNR_uc009wwu.1_Nonsense_Mutation_p.R528*	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	528	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					ACTTTGGCTCGAGGGGGAATC	0.552			NA											5	20					0	0	0.000602	0	0
C1orf49	84066	broad.mit.edu	37	1	178489911	178489911	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:178489911G>C	uc001glt.1	+	7	557	c.445G>C	c.(445-447)GTC>CTC	p.V149L	C1orf49_uc001glu.1_Missense_Mutation_p.V149L|C1orf49_uc001glv.1_RNA|C1orf49_uc001glw.1_Missense_Mutation_p.V157L	NM_032126	NP_115502	Q5T0J7	CA049_HUMAN	hypothetical protein LOC84066	149						microtubule cytoskeleton					0						AGCCAGTGGAGTCAATGGAGC	0.527			NA											3	44					0	0	0.000248	0	0
RGS8	85397	broad.mit.edu	37	1	182615944	182615944	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:182615944C>G	uc010pnw.1	-	7	727	c.469G>C	c.(469-471)GAC>CAC	p.D157H	RGS8_uc001gpn.1_Missense_Mutation_p.D157H|RGS8_uc001gpm.1_Missense_Mutation_p.D175H	NM_001102450	NP_001095920	P57771	RGS8_HUMAN	regulator of G-protein signalling 8 isoform 2	157	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)	1						GGGTAAGAGTCTTTCTCCATG	0.517	Ovarian(189;1262 3804 41973)		NA											40	133					0	0	0.00623	0	0
SMG7	9887	broad.mit.edu	37	1	183502430	183502430	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:183502430G>T	uc001gqg.2	+	9	1097	c.975G>T	c.(973-975)CAG>CAT	p.Q325H	SMG7_uc010pob.1_Missense_Mutation_p.Q354H|SMG7_uc001gqf.2_Missense_Mutation_p.Q325H|SMG7_uc001gqh.2_Missense_Mutation_p.Q325H|SMG7_uc001gqi.2_Missense_Mutation_p.Q283H|SMG7_uc010poc.1_Missense_Mutation_p.Q283H	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	325					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						AAGATGAGCAGCTATGTTGGA	0.398			NA											26	125					2.65835e-16	4.48677e-16	0.007291	1	0
CAMSAP1L1	23271	broad.mit.edu	37	1	200817734	200817734	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:200817734C>G	uc001gvl.2	+	12	2140	c.1870C>G	c.(1870-1872)CAC>GAC	p.H624D	CAMSAP1L1_uc001gvk.2_Missense_Mutation_p.H613D|CAMSAP1L1_uc001gvm.2_Missense_Mutation_p.H597D	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	624						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CACTGGAATTCACGTTCCTTC	0.368			NA											10	83					0	0	0.000978	0	0
NAV1	89796	broad.mit.edu	37	1	201781101	201781101	+	Missense_Mutation	SNP	A	A	G	rs148645972		TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:201781101A>G	uc001gwu.2	+	25	5361	c.5014A>G	c.(5014-5016)AGG>GGG	p.R1672G	NAV1_uc001gwx.2_Missense_Mutation_p.R1281G	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1675					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						CTTGAGCTTCAGGTAAGACCT	0.473			NA											4	109					0	0	0.000602	0	0
USH2A	7399	broad.mit.edu	37	1	216062258	216062258	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:216062258G>A	uc001hku.1	-	41	8120	c.7733C>T	c.(7732-7734)ACT>ATT	p.T2578I		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2578	Fibronectin type-III 12.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATTTCCAGGAGTTCTCAAGTA	0.408			NA								HNSCC(13;0.011)			14	104					0	0	0.004007	0	0
USH2A	7399	broad.mit.edu	37	1	216348701	216348701	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:216348701G>T	uc001hku.1	-	21	4907	c.4520C>A	c.(4519-4521)TCA>TAA	p.S1507*	USH2A_uc001hkv.2_Nonsense_Mutation_p.S1507*	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1507	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGGTAGAGATGACTCTCTCCT	0.443			NA								HNSCC(13;0.011)			12	34					3.07112e-06	4.74378e-06	0.000978	1	0
NVL	4931	broad.mit.edu	37	1	224495875	224495875	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:224495875C>T	uc001hok.2	-	6	476	c.433G>A	c.(433-435)GAA>AAA	p.E145K	NVL_uc001hol.2_Missense_Mutation_p.E39K|NVL_uc010pvd.1_Intron|NVL_uc010pve.1_Intron|NVL_uc010pvf.1_RNA	NM_002533	NP_002524	O15381	NVL_HUMAN	nuclear VCP-like isoform 1	145						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			skin(2)	2				GBM - Glioblastoma multiforme(131;0.00501)		GAGGTGGTTTCTCTTTGCTCC	0.433			NA											7	110					0	0	0.001984	0	0
TARBP1	6894	broad.mit.edu	37	1	234529176	234529176	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:234529176G>A	uc001hwd.2	-	28	4492	c.4492C>T	c.(4492-4494)CAG>TAG	p.Q1498*		NM_005646	NP_005637	Q13395	TARB1_HUMAN	TAR RNA binding protein 1	1498					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			CTGATACACTGAAGGCTGCCA	0.473			NA											4	46					0	0	0.000602	0	0
RYR2	6262	broad.mit.edu	37	1	237617733	237617733	+	Silent	SNP	C	C	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:237617733C>A	uc001hyl.1	+	15	1455	c.1335C>A	c.(1333-1335)GTC>GTA	p.V445V		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	445	Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTTCCACAGTCGATTTGCCTA	0.423			NA											12	50					7.93312e-07	1.25911e-06	0.00245	1	0
OR2L3	391192	broad.mit.edu	37	1	248224188	248224188	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:248224188G>C	uc001idx.1	+	1	205	c.205G>C	c.(205-207)GAC>CAC	p.D69H	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CTCCCTCATTGACCTAAATTA	0.423			NA											43	353					0	0	0.003214	0	0
NEBL	10529	broad.mit.edu	37	10	21108395	21108395	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr10:21108395C>T	uc001iqi.2	-	20	2410	c.2013G>A	c.(2011-2013)CCG>CCA	p.P671P	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron|NEBL_uc001iql.1_RNA	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	671	Nebulin 19.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						TCTCTATCTCCGGGGTCATGC	0.413			NA											43	122					0	0	0.003214	0	0
MLLT10	8028	broad.mit.edu	37	10	22015199	22015199	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr10:22015199C>T	uc001iqs.2	+	16	2301	c.1953C>T	c.(1951-1953)CTC>CTT	p.L651L	MLLT10_uc001iqt.2_Silent_p.L635L|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Silent_p.L635L|MLLT10_uc001ira.2_Silent_p.L92L|MLLT10_uc001irb.2_RNA	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	651	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						GATCTTCTCTCAGTCAGGCAC	0.313			NA	T	MLL|PICALM|CDK6	AL								24	231					0	0	0.005443	0	0
SLC18A3	6572	broad.mit.edu	37	10	50819573	50819573	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr10:50819573G>A	uc001jhw.2	+	1	1227	c.787G>A	c.(787-789)GCC>ACC	p.A263T	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank|CHAT_uc010qgs.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	263	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						GCTGGCAGTGGCCAAACCCTT	0.662			NA											3	16					0	0	0.004672	0	0
SLC18A3	6572	broad.mit.edu	37	10	50819935	50819935	+	Silent	SNP	A	A	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr10:50819935A>T	uc001jhw.2	+	1	1589	c.1149A>T	c.(1147-1149)CTA>CTT	p.L383L	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank|CHAT_uc010qgs.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	383	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						TCGCGCCGCTAGTGGTCTCAC	0.657			NA											8	26					0	0	0.000673	0	0
CLRN3	119467	broad.mit.edu	37	10	129676623	129676623	+	Silent	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr10:129676623G>A	uc001lka.1	-	3	634	c.471C>T	c.(469-471)TCC>TCT	p.S157S	CLRN3_uc001ljz.1_Silent_p.S89S	NM_152311	NP_689524	Q8NCR9	CLRN3_HUMAN	clarin 3	157						integral to membrane				skin(1)	1		all_epithelial(44;0.00168)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)|Colorectal(57;0.235)				ACAACTCTTCGGAGAGTTGGT	0.468			NA											11	45					0	0	0.000673	0	0
ZNF195	7748	broad.mit.edu	37	11	3380601	3380601	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr11:3380601C>G	uc001lxt.2	-	6	1815	c.1637G>C	c.(1636-1638)GGA>GCA	p.G546A	uc001lxr.2_5'Flank|ZNF195_uc001lxv.2_Missense_Mutation_p.G523A|ZNF195_uc001lxs.2_Missense_Mutation_p.G474A|ZNF195_uc010qxr.1_Missense_Mutation_p.G527A|ZNF195_uc009ydz.2_Missense_Mutation_p.G501A|ZNF195_uc001lxu.2_Missense_Mutation_p.G478A	NM_001130520	NP_001123992	O14628	ZN195_HUMAN	zinc finger protein 195 isoform 1	546					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		GGGTTTCTCTCCAGTATGAAT	0.403			NA											14	109					0	0	0.006122	0	0
OVCH2	341277	broad.mit.edu	37	11	7722003	7722003	+	Silent	SNP	C	C	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr11:7722003C>A	uc010rbf.1	-	7	741	c.741G>T	c.(739-741)CGG>CGT	p.R247R		NM_198185	NP_937828			ovochymase 2 precursor												0				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		CTTTCTTATTCCGGCACATGA	0.512			NA											6	11					2.0095e-06	3.14609e-06	0.001984	1	0
LIN7C	55327	broad.mit.edu	37	11	27520959	27520959	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr11:27520959C>T	uc001mrl.2	-	4	412	c.385G>A	c.(385-387)GAT>AAT	p.D129N	LIN7C_uc009yii.2_Missense_Mutation_p.D105N	NM_018362	NP_060832	Q9NUP9	LIN7C_HUMAN	lin-7 homolog C	129	PDZ.				exocytosis|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction					0						CCATGTCTATCAGCAATTCCA	0.413			NA											20	95					0	0	0.001882	0	0
SYT13	57586	broad.mit.edu	37	11	45274044	45274044	+	Silent	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr11:45274044G>A	uc001myq.2	-	4	900	c.774C>T	c.(772-774)CTC>CTT	p.L258L	SYT13_uc009yku.1_Silent_p.L114L	NM_020826	NP_065877	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	258	Cytoplasmic (Potential).|C2 1.					transport vesicle				ovary(1)	1						GGCCCAGGCGGAGCTCCCCGG	0.662			NA									OREG0020928	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	57					0	0	0.000602	0	0
OR4C15	81309	broad.mit.edu	37	11	55321870	55321870	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr11:55321870A>C	uc010rig.1	+	1	88	c.88A>C	c.(88-90)AAG>CAG	p.K30Q		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	Error:Variant_position_missing_in_Q8NGM1_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AATTGATCTGAAGCAAATTTT	0.343			NA								HNSCC(20;0.049)			4	168					0	0	0.000248	0	0
MYO7A	4647	broad.mit.edu	37	11	76885842	76885842	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr11:76885842C>A	uc001oyb.2	+	17	2248	c.1976C>A	c.(1975-1977)TCA>TAA	p.S659*	MYO7A_uc010rsl.1_Nonsense_Mutation_p.S659*|MYO7A_uc010rsm.1_Nonsense_Mutation_p.S648*|MYO7A_uc001oyc.2_Nonsense_Mutation_p.S659*|MYO7A_uc001oyd.2_5'UTR	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	659	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						CTGCGGTACTCAGGAATGATG	0.637			NA											3	11					0.004672	0.00690817	0.004672	1	0
C11orf82	220042	broad.mit.edu	37	11	82645329	82645329	+	Silent	SNP	T	T	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr11:82645329T>G	uc001ozt.2	+	6	3193	c.2949T>G	c.(2947-2949)CCT>CCG	p.P983P	C11orf82_uc010rsr.1_Silent_p.P682P|C11orf82_uc010rss.1_Silent_p.P682P|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	983					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						AAGGCCCACCTTCAGTGTGTG	0.408			NA											14	86					0	0	0.00245	0	0
RAB30	27314	broad.mit.edu	37	11	82693228	82693228	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr11:82693228C>G	uc001ozu.2	-	6	852	c.591G>C	c.(589-591)TTG>TTC	p.L197F	RAB30_uc009yve.2_Missense_Mutation_p.L195F|RAB30_uc010rst.1_Missense_Mutation_p.L195F|RAB30_uc001ozv.2_3'UTR	NM_014488	NP_055303	Q15771	RAB30_HUMAN	RAB30, member RAS oncogene family	197					protein transport|small GTPase mediated signal transduction	Golgi stack|plasma membrane	GTP binding|GTPase activity				0						TACAACAAGTCAAATAGCTGA	0.473			NA											3	127					0	0	0.004672	0	0
TAF1D	79101	broad.mit.edu	37	11	93469869	93469869	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr11:93469869G>C	uc001ped.2	-	5	886	c.684C>G	c.(682-684)ATC>ATG	p.I228M	SNORA8_uc001pec.2_5'Flank|TAF1D_uc001pdz.2_RNA|TAF1D_uc001pea.1_Intron|MIR1304_hsa-mir-1304|MI0006371_5'Flank|SNORA40_uc009ywh.2_5'Flank	NM_024116	NP_077021	Q9H5J8	TAF1D_HUMAN	TATA box binding protein (TBP)-associated	228					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding				0						CTGCCAATTTGATATCACATT	0.338			NA											4	74					0	0	0.000248	0	0
GRIA4	2893	broad.mit.edu	37	11	105795124	105795124	+	Splice_Site	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr11:105795124G>C	uc001pix.2	+	12	1923	c.1477_splice	c.e12-1	p.K493_splice	GRIA4_uc001piw.2_Splice_Site_p.K493_splice	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform						glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	TTCTCTTATAGAAAGCAGAGA	0.368			NA											11	100					0	0	0.001368	0	0
SDHD	6392	broad.mit.edu	37	11	111958662	111958662	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr11:111958662G>A	uc001pmz.2	+	2	195	c.134G>A	c.(133-135)GGA>GAA	p.G45E	TIMM8B_uc001pmx.2_5'Flank|TIMM8B_uc001pmy.2_5'Flank	NM_003002	NP_002993	O14521	DHSD_HUMAN	succinate dehydrogenase complex, subunit D	45					respiratory electron transport chain|transport|tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain complex II	electron carrier activity|heme binding|succinate dehydrogenase activity|ubiquinone binding				0		all_cancers(61;5.7e-14)|all_epithelial(67;3.4e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.13e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;1.05e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0515)	Succinic acid(DB00139)	GAATGGTGTGGAGTGCAGCAC	0.493			NA	Mis|N|F|S			paraganglioma|pheochromocytoma			Familial_Paragangliomas|Carney-Stratakis_syndrome|Cowden_syndrome				12	185					0	0	0.001368	0	0
GRIK4	2900	broad.mit.edu	37	11	120833308	120833308	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr11:120833308G>T	uc001pxn.2	+	18	2471	c.2184G>T	c.(2182-2184)GAG>GAT	p.E728D	GRIK4_uc009zav.1_Missense_Mutation_p.E728D|GRIK4_uc009zaw.1_Missense_Mutation_p.E728D|GRIK4_uc009zax.1_Missense_Mutation_p.E728D	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	728	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	CCATGAACGAGTACTATCGGC	0.557			NA											11	57					3.07112e-06	4.74378e-06	0.000978	1	0
OR8D2	283160	broad.mit.edu	37	11	124189796	124189796	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr11:124189796G>C	uc010sah.1	-	1	298	c.298C>G	c.(298-300)CAA>GAA	p.Q100E		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	100	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		AAATAAAGTTGAGTAATGCAT	0.408			NA											3	48					0	0	0.004672	0	0
CACNA1C	775	broad.mit.edu	37	12	2566832	2566832	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr12:2566832C>T	uc009zdu.1	+	5	1030	c.717C>T	c.(715-717)TTC>TTT	p.F239F	CACNA1C_uc009zdv.1_Silent_p.F239F|CACNA1C_uc001qkb.2_Silent_p.F239F|CACNA1C_uc001qkc.2_Silent_p.F239F|CACNA1C_uc001qke.2_Silent_p.F239F|CACNA1C_uc001qkf.2_Silent_p.F239F|CACNA1C_uc001qjz.2_Silent_p.F239F|CACNA1C_uc001qkd.2_Silent_p.F239F|CACNA1C_uc001qkg.2_Silent_p.F239F|CACNA1C_uc009zdw.1_Silent_p.F239F|CACNA1C_uc001qkh.2_Silent_p.F239F|CACNA1C_uc001qkl.2_Silent_p.F239F|CACNA1C_uc001qkn.2_Silent_p.F239F|CACNA1C_uc001qko.2_Silent_p.F239F|CACNA1C_uc001qkp.2_Silent_p.F239F|CACNA1C_uc001qkr.2_Silent_p.F239F|CACNA1C_uc001qku.2_Silent_p.F239F|CACNA1C_uc001qkq.2_Silent_p.F239F|CACNA1C_uc001qks.2_Silent_p.F239F|CACNA1C_uc001qkt.2_Silent_p.F239F|CACNA1C_uc001qka.1_5'UTR|CACNA1C_uc001qki.1_5'UTR|CACNA1C_uc001qkj.1_5'UTR|CACNA1C_uc001qkk.1_5'UTR|CACNA1C_uc001qkm.1_5'UTR	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	239	I.|Helical; Name=S4 of repeat I; (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TGAGGGCCTTCCGCGTGCTGC	0.557			NA											18	283					0	0	0.001216	0	0
NELL2	4753	broad.mit.edu	37	12	45173775	45173775	+	Silent	SNP	C	C	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr12:45173775C>A	uc001rog.2	-	4	961	c.366G>T	c.(364-366)CGG>CGT	p.R122R	NELL2_uc001rof.3_Silent_p.R121R|NELL2_uc001roh.2_Silent_p.R122R|NELL2_uc009zkd.2_Silent_p.R121R|NELL2_uc010skz.1_Silent_p.R172R|NELL2_uc010sla.1_Silent_p.R145R|NELL2_uc001roi.1_Silent_p.R122R|NELL2_uc010slb.1_Silent_p.R121R|NELL2_uc001roj.2_Silent_p.R122R	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	122	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TGACTTCATTCCGATGGCCAC	0.438			NA											10	74					2.17888e-05	3.32111e-05	0.006214	1	0
ACVRL1	94	broad.mit.edu	37	12	52310003	52310003	+	Missense_Mutation	SNP	G	G	A	rs121909284		TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr12:52310003G>A	uc001rzj.2	+	8	1515	c.1232G>A	c.(1231-1233)CGG>CAG	p.R411Q	ACVRL1_uc001rzk.2_Missense_Mutation_p.R411Q|ACVRL1_uc010snm.1_Missense_Mutation_p.R237Q	NM_000020	NP_000011	P37023	ACVL1_HUMAN	activin A receptor type II-like 1 precursor	411	Cytoplasmic (Potential).|Protein kinase.		R -> P (in HHT2).|R -> W (in HHT2).		blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	ATTGCCCGCCGGACCATCGTG	0.627			NA							Hereditary_Hemorrhagic_Telangiectasia				4	28					0	0	0.000248	0	0
KRT79	338785	broad.mit.edu	37	12	53227843	53227843	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr12:53227843G>T	uc001sbb.2	-	1	235	c.202C>A	c.(202-204)CAC>AAC	p.H68N		NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	68	Head.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						ATACTCTTGTGGCCCCCCAAG	0.652			NA											8	44					6.5536e-12	1.09543e-11	0.00308	1	0
TSPAN8	7103	broad.mit.edu	37	12	71531774	71531774	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr12:71531774C>T	uc009zrt.1	-	5	565	c.403G>A	c.(403-405)GAA>AAA	p.E135K	TSPAN8_uc001swk.1_Missense_Mutation_p.E135K|TSPAN8_uc001swj.1_Missense_Mutation_p.E135K	NM_004616	NP_004607	P19075	TSN8_HUMAN	transmembrane 4 superfamily member 3	135	Extracellular (Potential).				protein glycosylation	integral to membrane|lysosome	signal transducer activity			skin(2)|lung(1)|central_nervous_system(1)	4			LUSC - Lung squamous cell carcinoma(43;0.24)|OV - Ovarian serous cystadenocarcinoma(12;0.244)			AATTGTTTTTCACTTTCCCCT	0.338			NA											10	134					0	0	0.001368	0	0
RFX4	5992	broad.mit.edu	37	12	107080752	107080752	+	Silent	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr12:107080752G>A	uc001tlr.2	+	6	534	c.468G>A	c.(466-468)ACG>ACA	p.T156T	RFX4_uc010swv.1_RNA|RFX4_uc001tls.2_Silent_p.T165T|RFX4_uc001tlt.2_Silent_p.T165T|RFX4_uc001tlv.2_Silent_p.T62T|uc001tlu.3_5'Flank	NM_213594	NP_998759	Q33E94	RFX4_HUMAN	regulatory factor X4 isoform c	156					transcription, DNA-dependent	nucleus	DNA binding			upper_aerodigestive_tract(1)	1						TGAGTGAGACGGGCAAGAAAG	0.468			NA											14	172					0	0	0.00245	0	0
SVOP	55530	broad.mit.edu	37	12	109313526	109313526	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr12:109313526C>A	uc010sxh.1	-	12	1365	c.1193G>T	c.(1192-1194)GGG>GTG	p.G398V		NM_018711	NP_061181	Q8N4V2	SVOP_HUMAN	SV2 related protein	398	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity				0						CTTCTTGCGCCCCAGGCGGTC	0.418			NA											3	11					6.4e-05	9.71228e-05	0.004672	1	0
NAA25	80018	broad.mit.edu	37	12	112485592	112485592	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr12:112485592G>A	uc001ttm.2	-	17	1903	c.1883C>T	c.(1882-1884)TCA>TTA	p.S628L	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Missense_Mutation_p.S600L|NAA25_uc009zwa.1_Missense_Mutation_p.S628L	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	628						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						TAAACTGGTTGATCTGTGATA	0.333			NA											57	151					0	0	0.00361	0	0
POLE	5426	broad.mit.edu	37	12	133209087	133209087	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr12:133209087G>C	uc001uks.1	-	45	6188	c.6144C>G	c.(6142-6144)ATC>ATG	p.I2048M	POLE_uc001ukq.1_Missense_Mutation_p.I258M|POLE_uc001ukr.1_Missense_Mutation_p.I852M|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	2048					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GAGAGAAGGTGATCATTCCTG	0.552			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					40	134					0	0	0.001951	0	0
NALCN	259232	broad.mit.edu	37	13	101797225	101797225	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr13:101797225G>A	uc001vox.1	-	16	2051	c.1862C>T	c.(1861-1863)GCG>GTG	p.A621V	NALCN_uc001voy.2_Missense_Mutation_p.A336V	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	621	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTTGGTGTCCGCATTTGCTTC	0.333			NA											21	170					0	0	0.00278	0	0
CPNE6	9362	broad.mit.edu	37	14	24545604	24545604	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr14:24545604G>C	uc001wll.2	+	12	1193	c.1094G>C	c.(1093-1095)CGA>CCA	p.R365P	CPNE6_uc010tnv.1_Missense_Mutation_p.R420P|CPNE6_uc001wlm.2_Missense_Mutation_p.R190P|CPNE6_uc001wln.2_5'UTR	NM_006032	NP_006023	O95741	CPNE6_HUMAN	copine 6	365	VWFA.				lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0184)		TTTGGGGCTCGAATCCCCCCC	0.602			NA											32	106					0	0	0.002445	0	0
ZFP36L1	677	broad.mit.edu	37	14	69256498	69256498	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr14:69256498C>A	uc001xkh.1	-	2	899	c.769G>T	c.(769-771)GAG>TAG	p.E257*	ZFP36L1_uc001xki.1_Nonsense_Mutation_p.E257*	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	257					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CTTGCCAGCTCCTGGCTGGAG	0.632			NA									OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	151					1.3612e-06	2.1408e-06	0.003163	1	0
SNRPN	6638	broad.mit.edu	37	15	25221561	25221561	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr15:25221561G>T	uc001ywp.1	+	9	1155	c.265G>T	c.(265-267)GAT>TAT	p.D89Y	SNRPN_uc001ywq.1_Missense_Mutation_p.D89Y|SNRPN_uc001ywr.1_Missense_Mutation_p.D89Y|SNRPN_uc001yws.1_Missense_Mutation_p.D89Y|SNRPN_uc001ywt.1_Missense_Mutation_p.D89Y|SNRPN_uc001ywv.1_Missense_Mutation_p.D92Y|SNRPN_uc001yww.1_Missense_Mutation_p.D89Y|SNRPN_uc001ywx.1_Missense_Mutation_p.D89Y|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_Intron|SNRPN_uc001ywy.1_3'UTR	NM_022807	NP_073718	P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	89					RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			ovary(1)	1		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		ACCCCCCAAAGATGTAAGGAA	0.493			NA							Prader-Willsyndrome				9	43					1.12685e-05	1.73285e-05	0.004482	1	0
MGA	23269	broad.mit.edu	37	15	42052655	42052655	+	Silent	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr15:42052655C>G	uc010ucy.1	+	20	7507	c.7326C>G	c.(7324-7326)CTC>CTG	p.L2442L	MGA_uc010ucz.1_Silent_p.L2233L|MGA_uc010uda.1_Silent_p.L1058L	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2403	Helix-loop-helix motif.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TGAGGGATCTCTTTGAGAAAT	0.433			NA											4	91					0	0	0.000248	0	0
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42127270	42127270	+	Silent	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr15:42127270G>A	uc001zoo.3	+	3	361	c.321G>A	c.(319-321)CTG>CTA	p.L107L	JMJD7-PLA2G4B_uc001zom.2_Silent_p.L7L|JMJD7-PLA2G4B_uc001zon.2_Silent_p.L107L|JMJD7-PLA2G4B_uc010bcn.2_Silent_p.L107L|JMJD7-PLA2G4B_uc001zop.1_Silent_p.L7L|JMJD7-PLA2G4B_uc001zoq.3_5'Flank	NM_005090	NP_005081	P0C869	PA24B_HUMAN	JMJD7-PLA2G4B protein	Error:Variant_position_missing_in_P0C869_after_alignment					arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1						AGCGCCGCCTGCCCCTGAGCT	0.657			NA											24	71					0	0	0.00333	0	0
SGK269	79834	broad.mit.edu	37	15	77406519	77406519	+	Silent	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr15:77406519C>G	uc002bcm.2	-	6	5528	c.5220G>C	c.(5218-5220)GTG>GTC	p.V1740V		NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	1740					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		GCAGAATTTTCACAATACAAC	0.483			NA											5	113					0	0	0.000602	0	0
KIAA1199	57214	broad.mit.edu	37	15	81171078	81171078	+	Silent	SNP	T	T	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr15:81171078T>G	uc002bfw.1	+	3	371	c.111T>G	c.(109-111)CCT>CCG	p.P37P	KIAA1199_uc010unn.1_Silent_p.P37P	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	37										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						CTGGGTGCCCTGACCAGAGCC	0.587			NA											4	42					0	0	0.000248	0	0
PRC1	9055	broad.mit.edu	37	15	91512758	91512758	+	Silent	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr15:91512758C>G	uc002bqm.2	-	13	1825	c.1668G>C	c.(1666-1668)CTG>CTC	p.L556L	PRC1_uc002bqn.2_Silent_p.L556L|PRC1_uc002bqo.2_Silent_p.L556L|PRC1_uc010uqs.1_Silent_p.L515L	NM_003981	NP_003972	O43663	PRC1_HUMAN	protein regulator of cytokinesis 1 isoform 1	556	Unstructured, Arg/Lys rich.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			ovary(1)|skin(1)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					ACCCACCACTCAGGATGCTGC	0.547			NA											7	96					0	0	0.004482	0	0
SV2B	9899	broad.mit.edu	37	15	91769556	91769556	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr15:91769556C>T	uc002bqv.2	+	1	454	c.63C>T	c.(61-63)CGC>CGT	p.R21R	SV2B_uc002bqt.2_Silent_p.R21R|SV2B_uc010uqv.1_Intron|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	21	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GCTATTACCGCGGCAATGAGT	0.522			NA											7	31					0	0	0.00308	0	0
TARSL2	123283	broad.mit.edu	37	15	102241329	102241329	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr15:102241329C>G	uc002bxm.2	-	10	1335	c.1280G>C	c.(1279-1281)AGA>ACA	p.R427T	TARSL2_uc002bxl.2_5'UTR|TARSL2_uc010usi.1_RNA	NM_152334	NP_689547	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	427					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GAAGGCTCCTCTGGGAAGGAA	0.303			NA											3	60					0	0	0.004672	0	0
TBC1D24	57465	broad.mit.edu	37	16	2569287	2569287	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr16:2569287G>A	uc002cqm.2	+	2	1149	c.1034G>A	c.(1033-1035)GGA>GAA	p.G345E	ATP6V0C_uc002cqn.2_Missense_Mutation_p.E50K|ATP6V0C_uc002cqo.2_Missense_Mutation_p.E7K|AMDHD2_uc002cqp.2_5'Flank|AMDHD2_uc002cqq.2_5'Flank|AMDHD2_uc010uwc.1_5'Flank|AMDHD2_uc010uwd.1_5'Flank	NM_020705	NP_065756	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	Error:Variant_position_missing_in_Q9ULP9_after_alignment					neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity				0						CATGCGGCCGGAGCAGATCAT	0.622			NA											3	30					0	0	0.000248	0	0
ZNF434	54925	broad.mit.edu	37	16	3433615	3433615	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr16:3433615C>T	uc002cuz.2	-	6	1497	c.695G>A	c.(694-696)GGA>GAA	p.G232E	ZNF434_uc002cux.3_Missense_Mutation_p.G443E|ZNF434_uc010uwx.1_Missense_Mutation_p.G155E|ZNF434_uc002cuy.3_Missense_Mutation_p.G155E	NM_017810	NP_060280	Q9NX65	ZN434_HUMAN	zinc finger protein 434	232					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CCAATAAACTCCTCTGGACTT	0.403			NA											6	82					0	0	0.001168	0	0
ACSM1	116285	broad.mit.edu	37	16	20648732	20648732	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr16:20648732C>T	uc002dhm.1	-	8	1226	c.1158G>A	c.(1156-1158)CCG>CCA	p.P386P	ACSM1_uc002dhn.1_RNA|ACSM1_uc010bwg.1_Silent_p.P386P	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	386					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						CCATGAAACCCGGCTTGATCT	0.527			NA											30	124					0	0	0.002096	0	0
ITGAD	3681	broad.mit.edu	37	16	31408920	31408920	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr16:31408920G>A	uc002ebv.1	+	4	294	c.245G>A	c.(244-246)CGC>CAC	p.R82H	ITGAD_uc010vfl.1_Missense_Mutation_p.R82H|ITGAD_uc010cap.1_Missense_Mutation_p.R82H|ITGAD_uc002ebw.1_5'UTR	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	82	FG-GAP 2.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						CTTGCAGTCCGCCCTGAGGCC	0.617			NA											7	33					0	0	0.004482	0	0
SALL1	6299	broad.mit.edu	37	16	51174513	51174513	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr16:51174513G>T	uc010vgs.1	-	2	1651	c.1620C>A	c.(1618-1620)AGC>AGA	p.S540R	SALL1_uc010vgr.1_Missense_Mutation_p.S443R|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	540					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGTCTAGCCAGCTGGTGACTG	0.557	GBM(103;1352 1446 1855 4775 8890)		NA											16	63					1.3612e-06	2.1408e-06	0.003163	1	0
CHD9	80205	broad.mit.edu	37	16	53348933	53348933	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr16:53348933G>A	uc002ehb.2	+	35	7725	c.7561G>A	c.(7561-7563)GAA>AAA	p.E2521K	CHD9_uc002egy.2_Missense_Mutation_p.E2505K|CHD9_uc002ehc.2_Missense_Mutation_p.E2506K|CHD9_uc002ehf.2_Missense_Mutation_p.E1619K|CHD9_uc010cbw.2_Missense_Mutation_p.E587K	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2521					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				GGGTTATGTGGAAGATTTGGG	0.358			NA											4	56					0	0	0.000248	0	0
IRX6	79190	broad.mit.edu	37	16	55361654	55361654	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr16:55361654C>T	uc002ehy.2	+	4	1103	c.570C>T	c.(568-570)CTC>CTT	p.L190L	IRX6_uc002ehx.2_Silent_p.L190L|IRX6_uc010ccb.1_RNA	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	190	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						AGATGACCCTCACCCAGGTGT	0.572			NA											7	76					0	0	0.004482	0	0
CIRH1A	84916	broad.mit.edu	37	16	69189791	69189791	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr16:69189791C>G	uc002ews.3	+	11	1278	c.1182C>G	c.(1180-1182)ATC>ATG	p.I394M	CIRH1A_uc002ewr.2_Missense_Mutation_p.I394M|CIRH1A_uc002ewt.3_Missense_Mutation_p.I311M|CIRH1A_uc010cfi.2_Intron	NM_032830	NP_116219	Q969X6	CIR1A_HUMAN	cirhin	394						nucleolus	protein binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.125)		AGAACATTATCTGTAGCTGTA	0.423	Melanoma(69;1156 1278 4951 8715 52012)		NA											5	107					0	0	0.000602	0	0
DNAH2	146754	broad.mit.edu	37	17	7637925	7637925	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr17:7637925A>G	uc002giu.1	+	6	891	c.877A>G	c.(877-879)AAG>GAG	p.K293E	DNAH2_uc002git.2_Missense_Mutation_p.K293E|DNAH2_uc010vuk.1_Missense_Mutation_p.K293E	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	293	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGGCATCAGTAAGCAGCTGGT	0.532			NA											7	43					0	0	0.000978	0	0
MYH4	4622	broad.mit.edu	37	17	10354166	10354166	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr17:10354166C>T	uc002gmn.2	-	29	4023	c.3912G>A	c.(3910-3912)CAG>CAA	p.Q1304Q	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1304	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CTCGGGATAGCTGAGAAACCA	0.383			NA											17	53					0	0	0.006122	0	0
ZNF286A	57335	broad.mit.edu	37	17	15619791	15619791	+	Silent	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr17:15619791C>G	uc010cot.2	+	6	1149	c.753C>G	c.(751-753)CTC>CTG	p.L251L	ZNF286A_uc002goz.3_Silent_p.L139L|ZNF286A_uc010vwa.1_Silent_p.L251L|ZNF286A_uc002gpa.2_Silent_p.L251L	NM_001130842	NP_001124314	Q9HBT8	Z286A_HUMAN	zinc finger protein 286	251	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.0781)		GTGGTGAACTCTTCACCTACC	0.358			NA											6	52					0	0	0.001168	0	0
MPP3	4356	broad.mit.edu	37	17	41905172	41905172	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr17:41905172G>A	uc002iei.3	-	8	636	c.470C>T	c.(469-471)TCA>TTA	p.S157L	MPP3_uc002ieh.2_Missense_Mutation_p.S182L|MPP3_uc002iej.2_RNA|MPP3_uc010czi.1_Missense_Mutation_p.S157L|MPP3_uc010wik.1_Missense_Mutation_p.S182L	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	157	PDZ.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		AACAGCCCCTGAGTGCTCGTC	0.622			NA											15	95					0	0	0.007413	0	0
HOXB2	3212	broad.mit.edu	37	17	46620496	46620496	+	Silent	SNP	A	A	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr17:46620496A>G	uc002inm.2	-	2	1125	c.1005T>C	c.(1003-1005)CCT>CCC	p.P335P		NM_002145	NP_002136	P14652	HXB2_HUMAN	homeobox B2	335					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCTCGGAAAAAGGGACCGGGC	0.587			NA											3	133					0	0	0.004672	0	0
HELZ	9931	broad.mit.edu	37	17	65144729	65144729	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr17:65144729C>G	uc010wqk.1	-	20	2767	c.2580G>C	c.(2578-2580)AGG>AGC	p.R860S	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.R859S	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					ACAGGAGAATCCTACATGGGA	0.483			NA											23	322					0	0	0.002299	0	0
ABCA6	23460	broad.mit.edu	37	17	67079099	67079099	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr17:67079099C>G	uc002jhw.1	-	36	4706	c.4531G>C	c.(4531-4533)GAG>CAG	p.E1511Q		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1511	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					ACTTTTAGCTCTAGAATGTAA	0.433			NA											25	321					0	0	0.005443	0	0
BAIAP2	10458	broad.mit.edu	37	17	79060372	79060372	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr17:79060372G>A	uc002jzg.2	+	6	589	c.481G>A	c.(481-483)GAG>AAG	p.E161K	BAIAP2_uc002jyz.3_Missense_Mutation_p.E161K|BAIAP2_uc002jza.2_Missense_Mutation_p.E161K|BAIAP2_uc002jzc.2_Missense_Mutation_p.E161K|BAIAP2_uc002jzb.2_5'UTR|BAIAP2_uc002jzd.2_Missense_Mutation_p.E161K|BAIAP2_uc002jzf.2_Missense_Mutation_p.E161K|BAIAP2_uc002jze.2_Missense_Mutation_p.E194K|BAIAP2_uc010wuh.1_Missense_Mutation_p.E83K|BAIAP2_uc002jzh.2_Missense_Mutation_p.E162K	NM_017451	NP_059345	Q9UQB8	BAIP2_HUMAN	BAI1-associated protein 2 isoform 2	161	IMD.				axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding				0	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CTCGGACAAGGAGCTGCAGGT	0.632			NA											6	90					0	0	0.001984	0	0
CLUL1	27098	broad.mit.edu	37	18	641487	641487	+	Silent	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr18:641487G>A	uc002kkp.2	+	7	1300	c.1155G>A	c.(1153-1155)GTG>GTA	p.V385V	CLUL1_uc010wys.1_Silent_p.V437V|CLUL1_uc002kkq.2_Silent_p.V385V	NM_014410	NP_055225	Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal) precursor	385					cell death	extracellular region				ovary(2)	2						TTGGCTGGGTGTCTGAACTGG	0.493			NA											10	53					0	0	0.000978	0	0
KIAA0802	23255	broad.mit.edu	37	18	8813163	8813163	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr18:8813163G>A	uc002knr.2	+	12	2933	c.2791G>A	c.(2791-2793)GAC>AAC	p.D931N	KIAA0802_uc002knq.2_Missense_Mutation_p.D890N|KIAA0802_uc002kns.2_Missense_Mutation_p.D299N	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	1241	Potential.										0						GGAACTTCTCGACCGCCTGGA	0.597			NA											3	10					0	0	0.004672	0	0
DSC3	1825	broad.mit.edu	37	18	28588282	28588282	+	Silent	SNP	G	G	A	rs138254140		TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr18:28588282G>A	uc002kwj.3	-	10	1628	c.1473C>T	c.(1471-1473)AAC>AAT	p.N491N	DSC3_uc002kwi.3_Silent_p.N491N	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	491	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CCTTATAGCCGTTGATCTTTG	0.388			NA											5	46					0	0	0.000602	0	0
ZNF397OS	100101467	broad.mit.edu	37	18	32834195	32834195	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr18:32834195G>C	uc002kym.2	-	4	932	c.704C>G	c.(703-705)TCT>TGT	p.S235C	ZNF397_uc010dmq.2_Splice_Site_p.E186_splice|ZNF397_uc010dmr.2_Splice_Site|ZNF397_uc002kyj.2_Splice_Site_p.K216_splice|ZNF397OS_uc002kyl.2_5'Flank|ZNF397OS_uc010xce.1_Missense_Mutation_p.S235C	NM_001112734	NP_001106205	Q86W11	ZSC30_HUMAN	zinc finger protein 397 opposite strand	235					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TTGCTTCTTAGAGTTGTCCAG	0.478			NA											5	166					0	0	0.001984	0	0
SETBP1	26040	broad.mit.edu	37	18	42281614	42281614	+	Silent	SNP	A	A	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr18:42281614A>T	uc010dni.2	+	2	599	c.303A>T	c.(301-303)GGA>GGT	p.G101G	SETBP1_uc002lay.2_Silent_p.G101G	NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	101						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		TCACAGAGGGAAGTCTGAAGC	0.458			NA							Schinzel-Giedion_syndrome				15	75					0	0	0.003163	0	0
SLC14A1	6563	broad.mit.edu	37	18	43329823	43329823	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr18:43329823C>G	uc010xcn.1	+	11	1396	c.1077C>G	c.(1075-1077)ATC>ATG	p.I359M	SLC14A1_uc010dnk.2_Missense_Mutation_p.I415M|SLC14A1_uc002lbf.3_Missense_Mutation_p.I359M|SLC14A1_uc002lbg.3_RNA|SLC14A1_uc010xco.1_Missense_Mutation_p.I254M|SLC14A1_uc002lbh.3_Missense_Mutation_p.I251M|SLC14A1_uc002lbi.3_Missense_Mutation_p.I227M|SLC14A1_uc002lbj.3_Missense_Mutation_p.I415M|SLC14A1_uc002lbk.3_Missense_Mutation_p.I359M	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	359						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2						ATTCCAACATCTACAAGATGC	0.458			NA											3	113					0	0	0.004672	0	0
DOK6	220164	broad.mit.edu	37	18	67365639	67365639	+	Splice_Site	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr18:67365639G>C	uc002lkl.2	+	5	600	c.410_splice	c.e5-1	p.E137_splice		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6								insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				TCTCTTCACAGAGAGATTCAA	0.388			NA											9	46					0	0	0.000673	0	0
C19orf28	126321	broad.mit.edu	37	19	3546137	3546137	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr19:3546137C>G	uc002lxz.2	-	8	1394	c.1224G>C	c.(1222-1224)ATG>ATC	p.M408I	C19orf28_uc002lxw.2_Missense_Mutation_p.M408I|C19orf28_uc002lxx.2_Missense_Mutation_p.M408I|C19orf28_uc002lxy.2_Missense_Mutation_p.M399I	NM_174983	NP_778148	Q6NUT3	CS028_HUMAN	hypothetical protein LOC126321 isoform c	408	Helical; (Potential).				transmembrane transport	integral to membrane				breast(1)|pancreas(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00251)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAAGAAGCTCATGGAGCCGT	0.592			NA											9	45					0	0	0.006214	0	0
MUC16	94025	broad.mit.edu	37	19	9048000	9048000	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr19:9048000G>C	uc002mkp.2	-	5	33835	c.33631C>G	c.(33631-33633)CTG>GTG	p.L11211V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11213	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTAGTGACCAGTGAAGTCACC	0.488			NA											6	21					0	0	0.001168	0	0
MUC16	94025	broad.mit.edu	37	19	9071029	9071029	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr19:9071029G>A	uc002mkp.2	-	3	16621	c.16417C>T	c.(16417-16419)CAG>TAG	p.Q5473*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5475	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGTTAGTCTGAGAGATATTA	0.498			NA											9	78					0	0	0.006214	0	0
MUC16	94025	broad.mit.edu	37	19	9071370	9071370	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr19:9071370G>A	uc002mkp.2	-	3	16280	c.16076C>T	c.(16075-16077)CCC>CTC	p.P5359L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5361	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGAGAGGAGGGGATGCTCTG	0.527			NA											10	86					0	0	0.006214	0	0
NACC1	112939	broad.mit.edu	37	19	13249157	13249158	+	Missense_Mutation	DNP	GC	GC	TT			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr19:13249157_13249158GC>TT	uc002mwm.2	+	6	1689_1690	c.1521_1522GC>TT	c.(1519-1524)GAGCAT>GATTAT	p.507_508EH>DY		NM_052876	NP_443108	Q96RE7	NACC1_HUMAN	transcriptional repressor NAC1	507_508					negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization|transcription, DNA-dependent	cytoplasm|nuclear body					0						TGGGTGTGGAGCATGGCTTCGA	0.649			NA											12	80					0	0	0.004672	0	0
CYP4F2	8529	broad.mit.edu	37	19	15997064	15997064	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr19:15997064A>G	uc002nbs.1	-	8	1023	c.973T>C	c.(973-975)TTT>CTT	p.F325L	CYP4F2_uc010xot.1_Missense_Mutation_p.F176L|CYP4F2_uc010xou.1_Intron	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	325					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						TCAAACATAAAGGTGTCAGCT	0.562			NA											50	236					0	0	0.00361	0	0
TSHZ3	57616	broad.mit.edu	37	19	31770030	31770030	+	Silent	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr19:31770030G>A	uc002nsy.3	-	2	734	c.669C>T	c.(667-669)TAC>TAT	p.Y223Y		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	223	C2H2-type 1.				negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CCAGGGTGTCGTAGGCAGCGC	0.592			NA											33	131					0	0	0.003271	0	0
ZNF566	84924	broad.mit.edu	37	19	36940775	36940775	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr19:36940775C>T	uc002oea.3	-	5	443	c.361G>A	c.(361-363)GAT>AAT	p.D121N	ZNF566_uc010xte.1_Missense_Mutation_p.D121N|ZNF566_uc010xtf.1_Missense_Mutation_p.D122N|ZNF566_uc002oeb.3_Missense_Mutation_p.D121N|ZNF566_uc002oec.3_Missense_Mutation_p.D17N|ZNF566_uc010xtg.1_Missense_Mutation_p.D17N	NM_032838	NP_116227	Q969W8	ZN566_HUMAN	zinc finger protein 566 isoform 1	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					CATTCCCAATCATCTCTGAAA	0.383			NA											11	176					0	0	0.001368	0	0
SPTBN4	57731	broad.mit.edu	37	19	41078030	41078030	+	Silent	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr19:41078030C>G	uc002ony.2	+	34	7511	c.7425C>G	c.(7423-7425)CTC>CTG	p.L2475L	SPTBN4_uc002onz.2_Silent_p.L2475L|SPTBN4_uc010egx.2_Silent_p.L1218L	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	2475	PH.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AACCGCTGCTCAGCCTGCACA	0.597			NA											11	146					0	0	0.000673	0	0
PRKCG	5582	broad.mit.edu	37	19	54403973	54403973	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr19:54403973C>T	uc002qcq.1	+	14	1827	c.1545C>T	c.(1543-1545)TTC>TTT	p.F515F	PRKCG_uc010yeg.1_Silent_p.F515F|PRKCG_uc010yeh.1_Silent_p.F402F	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	515	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		CCCGCACCTTCTGCGGGACCC	0.557			NA											6	298					0	0	0.001984	0	0
ZSCAN22	342945	broad.mit.edu	37	19	58850179	58850179	+	Silent	SNP	G	G	A	rs139283341	byFrequency	TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr19:58850179G>A	uc002qsc.2	+	3	1110	c.963G>A	c.(961-963)GCG>GCA	p.A321A	ZSCAN22_uc010yhz.1_Missense_Mutation_p.R316Q	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	321					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		ACACAGGGGCGAAGCCCCATG	0.567			NA											8	89					0	0	0.004482	0	0
TPO	7173	broad.mit.edu	37	2	1418189	1418189	+	Silent	SNP	G	G	A	rs61758084		TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr2:1418189G>A	uc002qww.2	+	2	100	c.9G>A	c.(7-9)GCG>GCA	p.A3A	TPO_uc010ewj.2_Intron|TPO_uc010yin.1_Silent_p.A3A|TPO_uc002qwu.2_Silent_p.A3A|TPO_uc002qwr.2_Silent_p.A3A|TPO_uc002qwx.2_Silent_p.A3A|TPO_uc010yio.1_Silent_p.A3A|TPO_uc010yip.1_Silent_p.A3A	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	3					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GAATGAGAGCGCTCGCTGTGC	0.522			NA											4	18					0	0	0.000602	0	0
ADCY3	109	broad.mit.edu	37	2	25044432	25044432	+	Silent	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr2:25044432G>C	uc002rfs.3	-	19	3280	c.3081C>G	c.(3079-3081)CTC>CTG	p.L1027L	ADCY3_uc002rfr.3_Silent_p.L614L|ADCY3_uc010ykm.1_Silent_p.L1028L	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	1027	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					TGATGTTGGTGAGCGTATCCT	0.617			NA											3	163					0	0	0.004672	0	0
HEATR5B	54497	broad.mit.edu	37	2	37217795	37217795	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr2:37217795G>C	uc002rpp.1	-	34	5789	c.5693C>G	c.(5692-5694)CCA>CGA	p.P1898R	HEATR5B_uc002rpo.1_Missense_Mutation_p.P210R|HEATR5B_uc010ezy.1_Missense_Mutation_p.P393R	NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1898							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				ACTTACCCATGGGTCGCATGA	0.343			NA											8	51					0	0	0.00308	0	0
THADA	63892	broad.mit.edu	37	2	43779386	43779386	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr2:43779386G>A	uc002rsw.3	-	18	3119	c.2767C>T	c.(2767-2769)CGA>TGA	p.R923*	THADA_uc010far.2_Nonsense_Mutation_p.R192*|THADA_uc002rsx.3_Nonsense_Mutation_p.R923*|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_RNA|THADA_uc002rsz.2_Nonsense_Mutation_p.R633*|THADA_uc010fat.1_Nonsense_Mutation_p.R71*|THADA_uc002rta.2_Nonsense_Mutation_p.R633*|THADA_uc002rtb.1_Nonsense_Mutation_p.R923*	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	923							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				CAGTGGACTCGCCCATACATT	0.408			NA											4	18					0	0	0.000248	0	0
SMYD5	10322	broad.mit.edu	37	2	73448960	73448960	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr2:73448960G>C	uc002siw.2	+	6	573	c.544G>C	c.(544-546)GAC>CAC	p.D182H	SMYD5_uc010yre.1_Missense_Mutation_p.D66H|SMYD5_uc002six.1_5'Flank	NM_006062	NP_006053	Q6GMV2	SMYD5_HUMAN	SMYD family member 5	182							metal ion binding				0						GCAGGCGAAGGACAAGGACCG	0.453			NA											9	104					0	0	0.006214	0	0
PCGF1	84759	broad.mit.edu	37	2	74733992	74733992	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr2:74733992C>T	uc002slz.2	-	3	245	c.219G>A	c.(217-219)GTG>GTA	p.V73V	PCGF1_uc002sly.2_5'UTR	NM_032673	NP_116062	Q9BSM1	PCGF1_HUMAN	polycomb group ring finger 1	73	No repressor activity.|RING-type.				histone H2A monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PcG protein complex	protein C-terminus binding|zinc ion binding			ovary(1)	1						GGAGGTACTTCACAATACAAC	0.522			NA											10	75					0	0	0.001855	0	0
KCNJ3	3760	broad.mit.edu	37	2	155555493	155555493	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr2:155555493C>G	uc002tyv.1	+	1	401	c.206C>G	c.(205-207)TCG>TGG	p.S69W	KCNJ3_uc010zce.1_Missense_Mutation_p.S69W	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	69	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	CGCTACCTCTCGGACCTCTTC	0.592			NA											13	39					0	0	0.00245	0	0
TTN	7273	broad.mit.edu	37	2	179468736	179468736	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr2:179468736C>T	uc010zfg.1	-	231	47198	c.46974G>A	c.(46972-46974)TTG>TTA	p.L15658L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.L9353L|TTN_uc010zfi.1_Silent_p.L9286L|TTN_uc010zfj.1_Silent_p.L9161L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16585							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCACGCCTTTCAATCCCACTT	0.468			NA											26	358					0	0	0.007291	0	0
FAM126B	285172	broad.mit.edu	37	2	201873785	201873785	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr2:201873785C>G	uc002uws.3	-	7	629	c.441G>C	c.(439-441)TTG>TTC	p.L147F	FAM126B_uc002uwu.2_Missense_Mutation_p.L65F|FAM126B_uc002uwv.2_Missense_Mutation_p.L147F|FAM126B_uc002uww.1_Missense_Mutation_p.L147F	NM_173822	NP_776183	Q8IXS8	F126B_HUMAN	hypothetical protein LOC285172	147						intracellular				ovary(1)	1						CCCCTTCTGTCAAAGCCATGG	0.378			NA											8	83					0	0	0.004482	0	0
ABI2	10152	broad.mit.edu	37	2	204267336	204267336	+	Silent	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr2:204267336C>G	uc002vaa.2	+	9	1306	c.1071C>G	c.(1069-1071)GCC>GCG	p.A357A	ABI2_uc002uzz.2_Silent_p.A290A|ABI2_uc010zih.1_Silent_p.A5A|ABI2_uc010zii.1_Silent_p.A351A|ABI2_uc010zij.1_Silent_p.A234A|ABI2_uc002vab.2_Silent_p.A245A|ABI2_uc010zik.1_Silent_p.A82A|ABI2_uc010zil.1_Silent_p.A192A|ABI2_uc010zim.1_Silent_p.A143A|ABI2_uc002vac.2_Silent_p.A143A|ABI2_uc010zin.1_Silent_p.A5A	NM_005759	NP_005750	Q9NYB9	ABI2_HUMAN	abl interactor 2	357	Pro-rich.				actin polymerization or depolymerization|cell migration|peptidyl-tyrosine phosphorylation	cytoskeleton|cytosol|filopodium|lamellipodium	cytoskeletal adaptor activity|DNA binding|kinase binding|proline-rich region binding|SH3 domain binding|ubiquitin protein ligase binding				0						ATAGGCCTGCCTCTCGCCATA	0.423			NA											10	39					0	0	0.000673	0	0
NOP56	10528	broad.mit.edu	37	20	2636241	2636241	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr20:2636241G>T	uc002wgh.2	+	7	811	c.758G>T	c.(757-759)GGC>GTC	p.G253V	NOP56_uc010zpy.1_RNA|NOP56_uc002wgi.2_Missense_Mutation_p.G87V|NOP56_uc002wgm.1_5'UTR|SNORD86_uc010gaq.1_5'Flank|SNORD56_uc010gar.2_5'Flank|SNORD57_uc002wgo.1_5'Flank	NM_006392	NP_006383	O00567	NOP56_HUMAN	nucleolar protein 5A	253					rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			ovary(1)|pancreas(1)	2						TTTTTCCTAGGCATGGACATA	0.507			NA											11	86					2.27111e-07	3.6549e-07	0.001368	1	0
POFUT1	23509	broad.mit.edu	37	20	30804435	30804435	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr20:30804435C>T	uc002wxp.2	+	4	502	c.453C>T	c.(451-453)TTC>TTT	p.F151F	POFUT1_uc002wxo.2_Silent_p.F151F|POFUT1_uc010ztt.1_Silent_p.F43F|POFUT1_uc010ztu.1_Intron	NM_015352	NP_056167	Q9H488	OFUT1_HUMAN	protein O-fucosyltransferase 1 isoform 1	151					fucose metabolic process|Notch signaling pathway|O-glycan processing|regulation of transcription, DNA-dependent	endoplasmic reticulum|membrane	peptide-O-fucosyltransferase activity			breast(1)	1			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TTGGCCCATTCTGGGATCAGT	0.507			NA											11	100					0	0	0.001368	0	0
KCNB1	3745	broad.mit.edu	37	20	47990222	47990222	+	Silent	SNP	G	G	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr20:47990222G>T	uc002xur.1	-	2	2039	c.1875C>A	c.(1873-1875)GGC>GGA	p.G625G	KCNB1_uc002xus.1_Silent_p.G625G	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	625	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CTCCCCGCCAGCCCACTTCTG	0.607			NA											8	52					1.06961e-07	1.73749e-07	0.00308	1	0
ZFP64	55734	broad.mit.edu	37	20	50701362	50701362	+	Silent	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr20:50701362G>A	uc002xwk.2	-	9	2021	c.1672C>T	c.(1672-1674)CTG>TTG	p.L558L	ZFP64_uc002xwj.2_Silent_p.L339L	NM_199427	NP_955459	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform d	403					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						TCCTTGCCCAGAGGGGCCCGG	0.657			NA											4	38					0	0	0.000248	0	0
KRTAP20-2	337976	broad.mit.edu	37	21	32007755	32007755	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr21:32007755G>C	uc011adg.1	+	1	173	c.173G>C	c.(172-174)AGA>ACA	p.R58T		NM_181616	NP_853647	Q3LI61	KR202_HUMAN	keratin associated protein 20-2	58						intermediate filament				central_nervous_system(1)	1						TGCTATGGAAGATACTGGTCC	0.507			NA											12	163					0	0	0.000978	0	0
DOPEY2	9980	broad.mit.edu	37	21	37617525	37617525	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr21:37617525G>A	uc002yvg.2	+	19	3326	c.3247G>A	c.(3247-3249)GAG>AAG	p.E1083K	DOPEY2_uc011aeb.1_Missense_Mutation_p.E1032K|DOPEY2_uc002yvh.2_5'UTR	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1083					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						GCTGCGAGGCGAGCTGAGCGA	0.627			NA											6	42					0	0	0.001984	0	0
KRTAP10-10	353333	broad.mit.edu	37	21	46057941	46057941	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr21:46057941T>A	uc002zfq.2	+	1	669	c.607T>A	c.(607-609)TGC>AGC	p.C203S	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_181688	NP_859016	P60014	KR10A_HUMAN	keratin associated protein 10-10	203	14.|15 X 5 AA repeats of C-C-X(3).					keratin filament					0						GTCCACCTGCTGCGTGCCCGT	0.692			NA											35	75					0	0	0.00623	0	0
C21orf57	54059	broad.mit.edu	37	21	47706941	47706941	+	Silent	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr21:47706941G>C	uc002ziv.2	+	2	543	c.114G>C	c.(112-114)GGG>GGC	p.G38G	C21orf57_uc002zit.1_Silent_p.G38G|C21orf57_uc002ziu.1_Silent_p.G38G|C21orf57_uc002ziw.2_Intron|C21orf57_uc002zix.2_Silent_p.G38G|C21orf57_uc010gqh.2_Intron|C21orf57_uc002ziy.2_Silent_p.G38G|MCM3AP_uc002zir.1_5'Flank	NM_058181	NP_478061	P58557	YBEY_HUMAN	hypothetical protein LOC54059 isoform 1	38							metal ion binding|metalloendopeptidase activity				0	Breast(49;0.112)			Colorectal(79;0.236)		TTGACCTGGGGATCATCTGTG	0.418			NA											4	48					0	0	0.000248	0	0
TXNRD2	10587	broad.mit.edu	37	22	19865699	19865699	+	Silent	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr22:19865699C>G	uc011ahc.1	-	16	1392	c.1359G>C	c.(1357-1359)CTG>CTC	p.L453L	TXNRD2_uc002zql.1_Silent_p.L207L|TXNRD2_uc002zqm.1_RNA|TXNRD2_uc002zqn.1_RNA|TXNRD2_uc002zqo.1_RNA|TXNRD2_uc002zqp.1_RNA|TXNRD2_uc002zqr.1_Silent_p.L452L|TXNRD2_uc002zqj.1_RNA|TXNRD2_uc002zqq.1_Silent_p.L103L	NM_006440	NP_006431	Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2 precursor	453					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			ovary(2)	2	Colorectal(54;0.0993)					GGGGCTCCCTCAGGCACACCA	0.627			NA											3	28					0	0	0.004672	0	0
IL5RA	3568	broad.mit.edu	37	3	3139822	3139822	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr3:3139822T>C	uc011ask.1	-	7	1164	c.520A>G	c.(520-522)AGG>GGG	p.R174G	IL5RA_uc010hbq.2_Missense_Mutation_p.R174G|IL5RA_uc010hbr.2_Intron|IL5RA_uc010hbs.2_Missense_Mutation_p.R174G|IL5RA_uc011asl.1_Missense_Mutation_p.R174G|IL5RA_uc011asm.1_Missense_Mutation_p.R174G|IL5RA_uc010hbt.2_Missense_Mutation_p.R174G|IL5RA_uc011asn.1_Missense_Mutation_p.R174G|IL5RA_uc010hbu.2_Missense_Mutation_p.R174G	NM_000564	NP_000555	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha isoform 1	174	Extracellular (Potential).				cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			ovary(1)	1				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		AGTACTAACCTATAGTAGAGA	0.418	GBM(169;430 2801 24955 28528)		NA											15	58					0	0	0.004007	0	0
SLC6A6	6533	broad.mit.edu	37	3	14508105	14508105	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr3:14508105G>T	uc010heg.2	+	14	1105	c.814G>T	c.(814-816)GCA>TCA	p.A272S	SLC6A6_uc003byq.2_Missense_Mutation_p.A272S|SLC6A6_uc003byr.2_RNA	NM_001134367	NP_001127839	P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter	272				A -> R (in Ref. 1; CAA79481).	cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			ovary(1)	1						GGGCGCGGGCGCAGGCATCAA	0.622			NA											17	50					2.5808e-16	4.37723e-16	0.006122	1	0
KCNH8	131096	broad.mit.edu	37	3	19479731	19479731	+	Missense_Mutation	SNP	G	G	A	rs138531032	byFrequency	TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr3:19479731G>A	uc003cbk.1	+	8	1448	c.1253G>A	c.(1252-1254)CGA>CAA	p.R418Q	KCNH8_uc011awe.1_Missense_Mutation_p.R418Q|KCNH8_uc010hex.1_5'UTR|KCNH8_uc011awf.1_Missense_Mutation_p.R49Q	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	418	Extracellular (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						CCGTCGATCCGAAGTGCCTAT	0.493	NSCLC(124;1625 1765 8018 24930 42026)		NA											5	163					0	0	0.000602	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64507906	64507906	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr3:64507906C>T	uc003dmg.2	-	39	5781	c.5749G>A	c.(5749-5751)GGT>AGT	p.G1917S	ADAMTS9_uc011bfo.1_Missense_Mutation_p.G1889S|ADAMTS9_uc011bfp.1_Missense_Mutation_p.G828S	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1917	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CCACAGTAACCACCGCATTTC	0.493			NA											8	33					0	0	0.004482	0	0
C3orf26	84319	broad.mit.edu	37	3	99890704	99890704	+	Silent	SNP	A	A	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr3:99890704A>G	uc003dtl.2	+	7	683	c.540A>G	c.(538-540)GGA>GGG	p.G180G		NM_032359	NP_115735	Q9BQ75	CC026_HUMAN	hypothetical protein LOC84319	180							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(1)	1						CATTCAGAGGAGACGGCAAAG	0.413			NA											11	45					0	0	0.000978	0	0
ATP13A5	344905	broad.mit.edu	37	3	193081170	193081170	+	Missense_Mutation	SNP	T	T	A	rs150024258		TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr3:193081170T>A	uc011bsq.1	-	3	239	c.239A>T	c.(238-240)GAC>GTC	p.D80V		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	80					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		TTGAAATTCGTCCTGGAAAAG	0.388			NA											9	39					0	0	0.000673	0	0
SDHAP2	727956	broad.mit.edu	37	3	195404612	195404612	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr3:195404612C>T	uc003fuw.2	+	10	1363	c.169C>T	c.(169-171)CCA>TCA	p.P57S	SDHAP2_uc011btc.1_RNA|SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						TAAAGTCCCTCCAATTAAACC	0.348			NA											8	22					0	0	0.006214	0	0
TXK	7294	broad.mit.edu	37	4	48081936	48081936	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr4:48081936C>G	uc003gxx.3	-	11	1252	c.1166G>C	c.(1165-1167)AGG>ACG	p.R389T	TXK_uc010igj.2_RNA|TXK_uc011bzj.1_Missense_Mutation_p.R76T	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	389	Protein kinase.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TACCAAATCCCTATGAATATA	0.343			NA											4	120					0	0	0.000248	0	0
PDGFRA	5156	broad.mit.edu	37	4	55146502	55146502	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr4:55146502G>C	uc003han.3	+	16	2507	c.2176G>C	c.(2176-2178)GAA>CAA	p.E726Q	PDGFRA_uc003haa.2_Missense_Mutation_p.E486Q|PDGFRA_uc010igq.1_Missense_Mutation_p.E620Q|PDGFRA_uc003ham.2_RNA|PDGFRA_uc003hao.1_Missense_Mutation_p.E105Q	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	726	Protein kinase.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TTTATCTTTTGAAAACAATGG	0.393	Pancreas(151;208 1913 7310 23853 37092)		NA	Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			4	45					0	0	0.000602	0	0
ODAM	54959	broad.mit.edu	37	4	71066318	71066318	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr4:71066318G>T	uc003hfc.2	+	6	545	c.528G>T	c.(526-528)CAG>CAT	p.Q176H		NM_017855	NP_060325	A1E959	ODAM_HUMAN	odontogenic ameloblast-associated protein	176	Gln-rich.				biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				ovary(3)|large_intestine(1)	4						ATGAGGAGCAGGTACTGCAAA	0.358			NA											10	38					0.000978159	0.00145881	0.000978	1	0
WDFY3	23001	broad.mit.edu	37	4	85687162	85687162	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr4:85687162C>T	uc003hpd.2	-	32	5397	c.4989G>A	c.(4987-4989)GTG>GTA	p.V1663V		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1663						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CCAGTGTCTTCACCAGTTCTT	0.343			NA											5	72					0	0	0.001168	0	0
ARHGAP24	83478	broad.mit.edu	37	4	86893267	86893267	+	Silent	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr4:86893267G>C	uc003hpk.2	+	6	1127	c.678G>C	c.(676-678)GCG>GCC	p.A226A	ARHGAP24_uc003hpj.2_Silent_p.A226A|ARHGAP24_uc003hpl.2_Silent_p.A131A|ARHGAP24_uc010ikf.2_Silent_p.A141A|ARHGAP24_uc003hpm.2_Silent_p.A133A	NM_001025616	NP_001020787	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24 isoform 1	226	Rho-GAP.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		TTCCTTATGCGAAGTATGAAG	0.408			NA											7	85					0	0	0.004482	0	0
DAPP1	27071	broad.mit.edu	37	4	100774382	100774382	+	Silent	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr4:100774382G>A	uc003hvf.3	+	4	456	c.366G>A	c.(364-366)CTG>CTA	p.L122L	DAPP1_uc011cek.1_Intron|DAPP1_uc010ilh.2_Silent_p.L122L	NM_014395	NP_055210	Q9UN19	DAPP1_HUMAN	dual adaptor of phosphotyrosine and	122	SH2.				signal transduction	cytoplasm|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein tyrosine phosphatase activity				0				OV - Ovarian serous cystadenocarcinoma(123;7.04e-09)		CAGGCACTCTGATGGTTCTAA	0.423			NA											4	38					0	0	0.000248	0	0
CENPE	1062	broad.mit.edu	37	4	104064548	104064548	+	Missense_Mutation	SNP	C	C	G	rs146277781	byFrequency	TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr4:104064548C>G	uc003hxb.1	-	34	5251	c.5161G>C	c.(5161-5163)GAG>CAG	p.E1721Q	CENPE_uc003hxc.1_Missense_Mutation_p.E1696Q|CENPE_uc003hxd.1_5'Flank	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	1721	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTTAGCTCCTCTTGTTTTTCT	0.318			NA											5	173					0	0	0.001168	0	0
FAT4	79633	broad.mit.edu	37	4	126372722	126372722	+	Silent	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr4:126372722C>G	uc003ifj.3	+	9	10551	c.10551C>G	c.(10549-10551)GTC>GTG	p.V3517V	FAT4_uc011cgp.1_Silent_p.V1815V|FAT4_uc003ifi.1_Silent_p.V995V	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3517	Cadherin 34.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AAGGAGAAGTCATGGAAAACA	0.483			NA											9	178					0	0	0.006214	0	0
NPY2R	4887	broad.mit.edu	37	4	156135229	156135229	+	Silent	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr4:156135229G>A	uc003ioq.2	+	2	633	c.138G>A	c.(136-138)CTG>CTA	p.L46L	NPY2R_uc003ior.2_Silent_p.L46L	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	46	Extracellular (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				GTACCAAGCTGATTGAGGTAC	0.463			NA											10	59					0	0	0.000978	0	0
CYP4V2	285440	broad.mit.edu	37	4	187122497	187122497	+	Splice_Site	SNP	G	G	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr4:187122497G>T	uc003iyw.3	+	7	1291	c.987_splice	c.e7+1	p.E329_splice	CYP4V2_uc010ism.2_5'Flank	NM_207352	NP_997235	Q6ZWL3	CP4V2_HUMAN	cytochrome P450, family 4, subfamily v,						response to stimulus|visual perception	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.33e-10)|BRCA - Breast invasive adenocarcinoma(30;3.84e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000293)|LUSC - Lung squamous cell carcinoma(40;0.00242)|READ - Rectum adenocarcinoma(43;0.17)		CATGTTTGAGGTATTGTATAT	0.313			NA											9	72					9.70103e-10	1.58328e-09	0.000673	1	0
C6	729	broad.mit.edu	37	5	41160464	41160464	+	Silent	SNP	G	G	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr5:41160464G>T	uc003jmk.2	-	11	1674	c.1464C>A	c.(1462-1464)GCC>GCA	p.A488A	C6_uc003jml.1_Silent_p.A488A	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	488	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CCACGATGGGGGCAAGCTAGG	0.502			NA											14	59					2.61681e-11	4.35297e-11	0.00245	1	0
DEPDC1B	55789	broad.mit.edu	37	5	59901643	59901643	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr5:59901643C>G	uc003jsh.2	-	8	1012	c.939G>C	c.(937-939)CAG>CAC	p.Q313H	DEPDC1B_uc011cqm.1_Missense_Mutation_p.Q313H|DEPDC1B_uc011cqn.1_Missense_Mutation_p.Q286H	NM_018369	NP_060839	Q8WUY9	DEP1B_HUMAN	DEP domain containing 1B isoform 1	313	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)	1		Lung NSC(810;0.000214)|Prostate(74;0.0147)|Breast(144;0.0991)|Ovarian(174;0.17)				GGCAGCAAATCTGAAATGCTT	0.378			NA											9	141					0	0	0.004482	0	0
CMYA5	202333	broad.mit.edu	37	5	79026143	79026143	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr5:79026143C>A	uc003kgc.2	+	2	1627	c.1555C>A	c.(1555-1557)CCT>ACT	p.P519T		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	519	Glu-rich.					perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AGCTATTACCCCTGAACCTGA	0.413			NA											35	121					4.4194e-11	7.31633e-11	0.002836	1	0
DCP2	167227	broad.mit.edu	37	5	112337369	112337369	+	Silent	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr5:112337369G>A	uc003kqh.2	+	7	1002	c.804G>A	c.(802-804)TTG>TTA	p.L268L	DCP2_uc011cwa.1_Silent_p.L57L|DCP2_uc010jcc.2_Silent_p.L174L	NM_152624	NP_689837	Q8IU60	DCP2_HUMAN	DCP2 decapping enzyme	268					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus|RNA-induced silencing complex	exoribonuclease activity, producing 5'-phosphomonoesters|manganese ion binding|protein binding|protein binding|RNA binding				0		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		OV - Ovarian serous cystadenocarcinoma(64;6.98e-08)|Epithelial(69;7.87e-08)|all cancers(49;1.06e-05)|COAD - Colon adenocarcinoma(37;0.0123)|Colorectal(14;0.0171)		TGGAAAAATTGAGGTAAAGAA	0.373			NA											9	97					0	0	0.004482	0	0
IRF1	3659	broad.mit.edu	37	5	131822793	131822793	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr5:131822793C>G	uc003kxa.2	-	4	451	c.217G>C	c.(217-219)GAT>CAT	p.D73H	IRF1_uc003kxd.2_RNA|IRF1_uc003kxb.2_Missense_Mutation_p.D73H|IRF1_uc010jdt.1_Missense_Mutation_p.D73H	NM_002198	NP_002189	P10914	IRF1_HUMAN	interferon regulatory factor 1	73	IRF tryptophan pentad repeat.				blood coagulation|cellular response to mechanical stimulus|interferon-gamma-mediated signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleoplasm					0		all_cancers(142;0.026)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	LUAD - Lung adenocarcinoma(142;0.247)		GTCTTGGGATCTGGCTCCTTT	0.567			NA											5	324					0	0	0.000602	0	0
MATR3	9782	broad.mit.edu	37	5	138661298	138661298	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr5:138661298A>G	uc003ldu.2	+	16	2745	c.2318A>G	c.(2317-2319)TAT>TGT	p.Y773C	MATR3_uc003ldt.2_Missense_Mutation_p.Y435C|MATR3_uc003ldw.2_Missense_Mutation_p.Y821C|MATR3_uc003ldx.2_Missense_Mutation_p.Y773C|MATR3_uc010jfc.2_Missense_Mutation_p.Y773C|MATR3_uc011czb.1_Missense_Mutation_p.Y485C|MATR3_uc003ldz.2_Missense_Mutation_p.Y773C|MATR3_uc003lea.2_Missense_Mutation_p.Y773C|MATR3_uc003leb.2_Missense_Mutation_p.Y435C|MATR3_uc003lec.2_Missense_Mutation_p.Y450C	NM_199189	NP_954659	P43243	MATR3_HUMAN	matrin 3	773						nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			AAGGACGACTATACAATCCCA	0.423			NA											6	73					0	0	0.001168	0	0
PCDHB2	56133	broad.mit.edu	37	5	140476411	140476411	+	Silent	SNP	A	A	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr5:140476411A>C	uc003lil.2	+	1	2175	c.2037A>C	c.(2035-2037)GCA>GCC	p.A679A	PCDHB2_uc003lim.1_Silent_p.A340A	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	679	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGAGGCGGCACCGGCCCAGG	0.687			NA											11	144					0	0	0.001368	0	0
PCDHB4	56131	broad.mit.edu	37	5	140501869	140501869	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr5:140501869C>G	uc003lip.1	+	1	289	c.289C>G	c.(289-291)CCT>GCT	p.P97A		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	97	Cadherin 1.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTCTGTGGTCCTATTGAACC	0.483			NA											20	58					0	0	0.00278	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736874	140736874	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr5:140736874G>A	uc003ljq.1	+	1	2107	c.2107G>A	c.(2107-2109)GTC>ATC	p.V703I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGB2_uc003ljs.1_5'Flank|PCDHGA4_uc003ljp.1_Missense_Mutation_p.V703I|PCDHGB2_uc011dar.1_5'Flank	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	703	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTCTCCTGCGTCTTCCTGGC	0.607			NA											12	20					0	0	0.003163	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140740398	140740398	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr5:140740398C>T	uc003ljs.1	+	1	696	c.696C>T	c.(694-696)GTC>GTT	p.V232V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc011dar.1_Silent_p.V232V	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	232	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAATCAAAGTCACGGATGCCA	0.552			NA											4	26					0	0	0.000248	0	0
CCDC69	26112	broad.mit.edu	37	5	150584997	150584997	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr5:150584997C>G	uc003ltq.2	-	2	211	c.88G>C	c.(88-90)GAG>CAG	p.E30Q	CCDC69_uc010jhu.2_Intron|CCDC69_uc011dcq.1_RNA	NM_015621	NP_056436	A6NI79	CCD69_HUMAN	coiled-coil domain containing 69	30										ovary(2)	2		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCATGGGGCTCTGGTCTGGGT	0.552			NA											5	139					0	0	0.000602	0	0
ODZ2	57451	broad.mit.edu	37	5	167673884	167673884	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr5:167673884C>T	uc010jjd.2	+	27	5913	c.5913C>T	c.(5911-5913)ATC>ATT	p.I1971I	ODZ2_uc003lzr.3_Silent_p.I1741I|ODZ2_uc003lzt.3_Silent_p.I1344I|ODZ2_uc010jje.2_Silent_p.I1235I	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		ACACCTCCATCGGCTACATCC	0.532			NA											32	110					0	0	0.001786	0	0
OR2H2	7932	broad.mit.edu	37	6	29556336	29556336	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr6:29556336G>C	uc003nmr.1	+	1	654	c.615G>C	c.(613-615)TTG>TTC	p.L205F	GABBR1_uc003nmp.3_Intron	NM_007160	NP_009091	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H,	205	Helical; Name=5; (Potential).				defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCTTCATCTTGGTTGTGCCTC	0.507			NA											13	121					0	0	0.001855	0	0
EYS	346007	broad.mit.edu	37	6	66204732	66204732	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr6:66204732C>A	uc011dxu.1	-	4	1110	c.572G>T	c.(571-573)AGT>ATT	p.S191I	EYS_uc003peq.2_Missense_Mutation_p.S191I|EYS_uc003per.1_Missense_Mutation_p.S191I|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	191	EGF-like 1.				response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						CCAAGCTTCACTAAGACATTT	0.423			NA											7	28					0.00198382	0.00294593	0.001984	1	0
COL9A1	1297	broad.mit.edu	37	6	70944631	70944631	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr6:70944631C>G	uc003pfg.3	-	34	2284	c.2125G>C	c.(2125-2127)GGG>CGG	p.G709R	COL9A1_uc003pfe.3_Missense_Mutation_p.G258R|COL9A1_uc003pff.3_Missense_Mutation_p.G466R	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	709	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						CCAGGTTCCCCAGGATTACCT	0.522			NA											8	29					0	0	0.006214	0	0
ELOVL4	6785	broad.mit.edu	37	6	80636031	80636031	+	Nonsense_Mutation	SNP	A	A	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr6:80636031A>C	uc003pja.3	-	2	487	c.168T>G	c.(166-168)TAT>TAG	p.Y56*	ELOVL4_uc011dyt.1_Intron	NM_022726	NP_073563	Q9GZR5	ELOV4_HUMAN	elongation of very long chain fatty acids-like	56	Helical; (Potential).				fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	G-protein coupled photoreceptor activity|protein binding|transferase activity, transferring acyl groups other than amino-acyl groups			ovary(1)|skin(1)	2		all_cancers(76;1.83e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.011)		BRCA - Breast invasive adenocarcinoma(397;0.0168)	Alpha-Linolenic Acid(DB00132)	CAAACAGGAGATAAAGAGTGC	0.398			NA											4	40					0	0	0.000248	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90578701	90578701	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr6:90578701C>G	uc003pnr.2	+	8	5888	c.5692C>G	c.(5692-5694)CCA>GCA	p.P1898A	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.P1898A|CASP8AP2_uc011dzz.1_Missense_Mutation_p.P1898A	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1898	NCOA2-binding.				cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		AAAGGCAACCCCAGGGATTAA	0.398	Colon(187;1656 2025 17045 31481 39901)		NA											4	18					0	0	0.000248	0	0
FHL5	9457	broad.mit.edu	37	6	97053872	97053872	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr6:97053872C>T	uc003pos.1	+	5	834	c.429C>T	c.(427-429)ATC>ATT	p.I143I	FHL5_uc003pot.1_Silent_p.I143I	NM_020482	NP_065228	Q5TD97	FHL5_HUMAN	activator of cAMP-responsive element modulator	143	LIM zinc-binding 2.					nucleus	zinc ion binding			ovary(2)	2		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		AGCCTTTGATCTCCAAAGAGA	0.413			NA											5	68					0	0	0.000602	0	0
ROS1	6098	broad.mit.edu	37	6	117647511	117647511	+	Silent	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr6:117647511G>A	uc003pxp.1	-	33	5632	c.5433C>T	c.(5431-5433)TGC>TGT	p.C1811C	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1811	Fibronectin type-III 9.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		AAACACTACTGCAGGATCCAT	0.333			NA	T	GOPC|ROS1	glioblastoma|NSCLC								7	47					0	0	0.00308	0	0
NKAIN2	154215	broad.mit.edu	37	6	125139557	125139557	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr6:125139557C>G	uc003pzo.2	+	6	837	c.560C>G	c.(559-561)TCT>TGT	p.S187C	NKAIN2_uc003pzp.2_Missense_Mutation_p.S186C|NKAIN2_uc010keq.2_Missense_Mutation_p.S120C|NKAIN2_uc010ker.2_Missense_Mutation_p.S97C	NM_001040214	NP_001035304	Q5VXU1	NKAI2_HUMAN	T-cell lymphoma breakpoint-associated target 1	187						integral to membrane|plasma membrane					0				GBM - Glioblastoma multiforme(226;0.104)		GGCTTTGACTCTTATGGCTAT	0.378			NA											11	65					0	0	0.00245	0	0
ENPP3	5169	broad.mit.edu	37	6	131973770	131973770	+	Silent	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr6:131973770G>A	uc003qcu.3	+	5	713	c.366G>A	c.(364-366)AGG>AGA	p.R122R	ENPP3_uc010kfn.1_RNA|ENPP3_uc011ecc.1_Silent_p.R88R|ENPP3_uc010kfo.1_RNA|ENPP3_uc010kfp.1_RNA|ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Silent_p.R122R	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	122	Extracellular (Potential).|SMB 2.			R -> K (in Ref. 1; AAC51813).	immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		GTTTGCAGAGGAAAGATTGCT	0.448			NA											10	82					0	0	0.001368	0	0
ENPP3	5169	broad.mit.edu	37	6	131973774	131973774	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr6:131973774G>A	uc003qcu.3	+	5	717	c.370G>A	c.(370-372)GAT>AAT	p.D124N	ENPP3_uc010kfn.1_RNA|ENPP3_uc011ecc.1_Missense_Mutation_p.D90N|ENPP3_uc010kfo.1_RNA|ENPP3_uc010kfp.1_RNA|ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Missense_Mutation_p.D124N	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	124	Extracellular (Potential).|SMB 2.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		GCAGAGGAAAGATTGCTGTGC	0.453			NA											10	82					0	0	0.000978	0	0
UTRN	7402	broad.mit.edu	37	6	145156988	145156988	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr6:145156988G>C	uc003qkt.2	+	69	9830	c.9738G>C	c.(9736-9738)CAG>CAC	p.Q3246H		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	3246					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GCCAGCCGCAGAGCCCAGCTC	0.552			NA											9	117					0	0	0.004482	0	0
C6orf211	79624	broad.mit.edu	37	6	151789867	151789867	+	Silent	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr6:151789867G>A	uc003qok.1	+	5	1207	c.948G>A	c.(946-948)GGG>GGA	p.G316G	C6orf211_uc011ees.1_Silent_p.G197G	NM_024573	NP_078849	Q9H993	CF211_HUMAN	hypothetical protein LOC79624	316							protein binding				0			BRCA - Breast invasive adenocarcinoma(37;0.183)	OV - Ovarian serous cystadenocarcinoma(155;5.27e-11)		CCAAGTGTGGGGCTGACTGGG	0.373			NA											9	76					0	0	0.006214	0	0
TTYH3	80727	broad.mit.edu	37	7	2697955	2697955	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:2697955C>T	uc003smp.2	+	12	1473	c.1286C>T	c.(1285-1287)CCA>CTA	p.P429L	TTYH3_uc010ksn.2_Missense_Mutation_p.P149L|TTYH3_uc003smq.2_Missense_Mutation_p.P258L	NM_025250	NP_079526	Q9C0H2	TTYH3_HUMAN	tweety 3	429	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)		GAGGCCGCTCCAGGGCCGCGG	0.697			NA											3	26					0	0	0.004672	0	0
SDK1	221935	broad.mit.edu	37	7	4273011	4273011	+	Silent	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:4273011G>A	uc003smx.2	+	41	6091	c.5952G>A	c.(5950-5952)GCG>GCA	p.A1984A	SDK1_uc010kso.2_Silent_p.A1240A|SDK1_uc003smy.2_Silent_p.A471A|SDK1_uc003smz.2_Silent_p.A44A	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1984	Fibronectin type-III 13.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TGAATGAGGCGGGCTACGGGG	0.617			NA											8	108					0	0	0.004482	0	0
GLCCI1	113263	broad.mit.edu	37	7	8062112	8062112	+	Splice_Site	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:8062112G>A	uc003srk.2	+	3	1169	c.610_splice	c.e3-1	p.T204_splice		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1												0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		attttttaaaGACACCTAGCT	0.343			NA											4	43					0	0	0.000602	0	0
BZW2	28969	broad.mit.edu	37	7	16736596	16736596	+	Silent	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:16736596G>A	uc003stl.2	+	9	1057	c.879G>A	c.(877-879)GTG>GTA	p.V293V	BZW2_uc011jxx.1_Silent_p.V99V|BZW2_uc003stm.2_Silent_p.V99V|BZW2_uc003stj.2_Silent_p.V293V|BZW2_uc003stk.2_Silent_p.V217V|BZW2_uc003sto.1_Silent_p.V141V|BZW2_uc003stp.2_Silent_p.V141V|BZW2_uc010kua.2_Silent_p.V293V	NM_001159767	NP_001153239	Q9Y6E2	BZW2_HUMAN	basic leucine zipper and W2 domains 2	293	W2.				cell differentiation|nervous system development|RNA metabolic process		protein binding			ovary(2)	2	Lung NSC(10;0.0367)|all_lung(11;0.0837)			UCEC - Uterine corpus endometrioid carcinoma (126;0.199)		AAACAGCAGTGATTGGTCTTC	0.443			NA											4	84					0	0	0.000248	0	0
AGR2	10551	broad.mit.edu	37	7	16841359	16841359	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:16841359C>G	uc003str.2	-	2	249	c.62G>C	c.(61-63)AGA>ACA	p.R21T	AGR2_uc011jxy.1_Missense_Mutation_p.R21T	NM_006408	NP_006399	O95994	AGR2_HUMAN	anterior gradient 2 homolog precursor	21					mucus secretion	endoplasmic reticulum|extracellular region	protein binding				0	Lung NSC(10;0.0376)|all_lung(11;0.0855)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		TGTGGTATCTCTGGCCAGAGT	0.498			NA											17	68					0	0	0.006122	0	0
CREB5	9586	broad.mit.edu	37	7	28858876	28858876	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:28858876G>T	uc003szq.2	+	11	1897	c.1507G>T	c.(1507-1509)GAC>TAC	p.D503Y	CREB5_uc003szo.2_Missense_Mutation_p.D470Y|CREB5_uc003szr.2_Missense_Mutation_p.D496Y|CREB5_uc003szs.2_Missense_Mutation_p.D364Y	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	503					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						TCACAGAACAGACCTGAATCC	0.478			NA											13	135					0.000151284	0.000228578	0.001855	1	0
PKD1L1	168507	broad.mit.edu	37	7	47870862	47870862	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:47870862C>T	uc003tny.1	-	42	6426	c.6426G>A	c.(6424-6426)GGG>GGA	p.G2142G	C7orf69_uc003toa.1_RNA	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2142	Helical; (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						AAGAAGCGGTCCCACAAATGG	0.552			NA											32	66					0	0	0.001512	0	0
ZNF479	90827	broad.mit.edu	37	7	57188673	57188673	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:57188673G>C	uc010kzo.2	-	5	720	c.449C>G	c.(448-450)TCA>TGA	p.S150*		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TTGGGTAGTTGACAAACATTG	0.299			NA											9	118					0	0	0.000673	0	0
CYP51A1	1595	broad.mit.edu	37	7	91752461	91752461	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:91752461C>G	uc003ulm.3	-	7	1221	c.1059G>C	c.(1057-1059)GAG>GAC	p.E353D	CYP51A1_uc011khn.1_Missense_Mutation_p.E248D|CYP51A1_uc003uln.3_Missense_Mutation_p.E290D	NM_000786	NP_000777	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A,	347					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity				0	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	GAGGCAGATTCTCTCCACAGA	0.373	GBM(70;1100 1190 11592 25836 51397)		NA											4	102					0	0	0.000248	0	0
COL1A2	1278	broad.mit.edu	37	7	94038733	94038733	+	Splice_Site	SNP	G	G	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:94038733G>T	uc003ung.1	+	17	1362	c.891_splice	c.e17+1	p.P297_splice	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor						axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TGGACCTCCTGTAAGTAGCCA	0.507			NA								HNSCC(75;0.22)			27	74					4.87955e-14	8.19576e-14	0.005443	1	0
PON3	5446	broad.mit.edu	37	7	94989416	94989416	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:94989416C>T	uc003unt.2	-	9	959	c.934G>A	c.(934-936)GAG>AAG	p.E312K	PON1_uc011kih.1_Intron	NM_000940	NP_000931	Q15166	PON3_HUMAN	paraoxonase 3	312					aromatic compound catabolic process|carboxylic acid catabolic process|response to external stimulus	extracellular space	aryldialkylphosphatase activity|arylesterase activity|metal ion binding|protein homodimerization activity			ovary(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			CTGGGCTTCTCAGACAAAACA	0.453			NA											11	121					0	0	0.001368	0	0
PILRB	29990	broad.mit.edu	37	7	99956586	99956586	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:99956586C>G	uc003uuk.2	+	16	2834	c.338C>G	c.(337-339)TCA>TGA	p.S113*	PILRB_uc003uul.2_Silent_p.L43L|PILRB_uc003uum.1_RNA|PILRB_uc003uun.2_Nonsense_Mutation_p.S113*	NM_013440	NP_038468	Q9UKJ0	PILRB_HUMAN	paired immunoglobulin-like type 2 receptor beta	113	Extracellular (Potential).|Ig-like V-type.				activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTCAGGATCTCAAACCTGCGG	0.552			NA											11	131					0	0	0.000978	0	0
GNB2	2783	broad.mit.edu	37	7	100275742	100275742	+	Silent	SNP	A	A	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:100275742A>T	uc003uwb.2	+	8	792	c.519A>T	c.(517-519)ACA>ACT	p.T173T	GNB2_uc003uwc.2_Silent_p.T129T|GNB2_uc010lhd.2_Silent_p.T129T|GNB2_uc010lhe.2_Silent_p.T129T|GNB2_uc003uwd.2_Silent_p.T73T|GNB2_uc010lhf.2_Silent_p.T73T|GNB2_uc003uwe.2_Silent_p.T173T|GNB2_uc003uwf.2_Silent_p.T73T	NM_005273	NP_005264	P62879	GBB2_HUMAN	guanine nucleotide-binding protein, beta-2	173					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	perinuclear region of cytoplasm|plasma membrane	GTPase activity|GTPase binding|signal transducer activity			ovary(2)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)	Ovarian(593;0.238)				ACATTGAGACAGGCCAGCAGA	0.587			NA											15	48					0	0	0.003163	0	0
ZAN	7455	broad.mit.edu	37	7	100345986	100345986	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:100345986C>A	uc003uwj.2	+	11	1307	c.1142C>A	c.(1141-1143)CCC>CAC	p.P381H	ZAN_uc003uwk.2_Missense_Mutation_p.P381H|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	381	MAM 3.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AACGCCCATCCCTTCTGTGAC	0.567			NA											18	63					1.15919e-05	1.77468e-05	0.001216	1	0
MET	4233	broad.mit.edu	37	7	116435946	116435946	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:116435946A>G	uc003vij.2	+	21	4128	c.3941A>G	c.(3940-3942)GAA>GGA	p.E1314G	MET_uc010lkh.2_Missense_Mutation_p.E1332G|MET_uc011knj.1_Missense_Mutation_p.E884G	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	1314	Protein kinase.|Interaction with RANBP9.|Cytoplasmic (Potential).				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			AACAGATATGAAGTAATGCTA	0.428			NA	Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				20	89					0	0	0.001523	0	0
CFTR	1080	broad.mit.edu	37	7	117282538	117282538	+	Nonsense_Mutation	SNP	C	C	G	rs76649725		TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:117282538C>G	uc003vjd.2	+	23	3896	c.3764C>G	c.(3763-3765)TCA>TGA	p.S1255*	CFTR_uc011knq.1_Nonsense_Mutation_p.S661*	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	1255	Cytoplasmic (Potential).|ABC transporter 2.		S -> P (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	ACTTTGTTATCAGCTTTTTTG	0.433			NA							Cystic_Fibrosis				6	67					0	0	0.001984	0	0
FSCN3	29999	broad.mit.edu	37	7	127240303	127240303	+	Silent	SNP	C	C	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:127240303C>A	uc003vmd.1	+	6	1566	c.1347C>A	c.(1345-1347)GGC>GGA	p.G449G	FSCN3_uc011koh.1_Missense_Mutation_p.Q314K|FSCN3_uc010llc.1_Missense_Mutation_p.Q448K	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	449						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1						GCCCTTGGGGCAAGTTTGCCC	0.557			NA											9	43					7.48243e-07	1.19305e-06	0.006214	1	0
DENND2A	27147	broad.mit.edu	37	7	140301553	140301553	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:140301553C>G	uc010lnj.2	-	1	790	c.645G>C	c.(643-645)CAG>CAC	p.Q215H	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.Q215H|DENND2A_uc003vvw.2_Missense_Mutation_p.Q215H|DENND2A_uc003vvx.2_Missense_Mutation_p.Q215H	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	215										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					GGTGGACCCTCTGGCTGACTT	0.632			NA											5	128					0	0	0.000602	0	0
PAXIP1	22976	broad.mit.edu	37	7	154738478	154738478	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:154738478T>C	uc003wlp.2	-	18	3011	c.2968A>G	c.(2968-2970)ACT>GCT	p.T990A	LOC100132707_uc011kvr.1_RNA|LOC100132707_uc003wlo.2_RNA|PAXIP1_uc003wlq.1_Missense_Mutation_p.T956A|PAXIP1_uc011kvs.1_Missense_Mutation_p.T954A	NM_007349	NP_031375	Q6ZW49	PAXI1_HUMAN	PAX interacting protein 1	990	Interaction with TP53BP1.|BRCT 6.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		GCCTTCATAGTGGAAAGACTT	0.383			NA											4	17					0	0	0.000602	0	0
RP1L1	94137	broad.mit.edu	37	8	10464923	10464923	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr8:10464923C>T	uc003wtc.2	-	4	6914	c.6685G>A	c.(6685-6687)GAG>AAG	p.E2229K		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	2229					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TCCGGGGTCTCTACGCCTTCT	0.602			NA											15	147					0	0	0.004007	0	0
TEX15	56154	broad.mit.edu	37	8	30704595	30704595	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr8:30704595C>T	uc003xil.2	-	1	1939	c.1939G>A	c.(1939-1941)GAA>AAA	p.E647K		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	647										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GTATCAATTTCACAATCAGAA	0.299			NA											15	28					0	0	0.00245	0	0
DDHD2	23259	broad.mit.edu	37	8	38105235	38105235	+	Missense_Mutation	SNP	C	C	T	rs145943165	byFrequency	TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr8:38105235C>T	uc003xlb.2	+	10	1507	c.1130C>T	c.(1129-1131)TCG>TTG	p.S377L	DDHD2_uc003xlc.2_Missense_Mutation_p.S377L|DDHD2_uc011lbl.1_Missense_Mutation_p.S189L|DDHD2_uc003xld.2_5'UTR	NM_015214	NP_056029	O94830	DDHD2_HUMAN	DDHD domain containing 2 isoform 1	377					lipid catabolic process	centrosome	hydrolase activity|metal ion binding			large_intestine(1)|ovary(1)	2	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			TTTTAGGATTCGCTAAATATT	0.294			NA											6	76					0	0	0.001168	0	0
CHRNA6	8973	broad.mit.edu	37	8	42611669	42611669	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr8:42611669C>G	uc003xpj.2	-	5	719	c.673G>C	c.(673-675)GAG>CAG	p.E225Q	CHRNA6_uc011lcw.1_Missense_Mutation_p.E210Q	NM_004198	NP_004189	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6	225	Extracellular.					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GTGTATATCTCTTCACAACAG	0.338			NA											7	87					0	0	0.001984	0	0
RB1CC1	9821	broad.mit.edu	37	8	53569134	53569134	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr8:53569134C>T	uc003xre.3	-	15	3813	c.3255G>A	c.(3253-3255)CAG>CAA	p.Q1085Q	RB1CC1_uc003xrf.3_Silent_p.Q1085Q	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	1085	Potential.				autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				AGGTCTCCTTCTGCTGGGCTC	0.358	GBM(180;1701 2102 13475 42023 52570)		NA											15	69					0	0	0.003163	0	0
JPH1	56704	broad.mit.edu	37	8	75227253	75227253	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr8:75227253C>T	uc003yae.2	-	2	1022	c.982G>A	c.(982-984)GAG>AAG	p.E328K	JPH1_uc003yaf.2_Missense_Mutation_p.E328K|JPH1_uc003yag.1_Missense_Mutation_p.E192K	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	328	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			TATTTTCCCTCTTCTTTGGAG	0.448			NA											10	151					0	0	0.006214	0	0
CRISPLD1	83690	broad.mit.edu	37	8	75924672	75924672	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr8:75924672G>A	uc003yan.2	+	3	638	c.263G>A	c.(262-264)TGG>TAG	p.W88*	CRISPLD1_uc011lfk.1_5'UTR|CRISPLD1_uc011lfl.1_5'UTR	NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	88						extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			CTGTAGACATGGGATGTAGAG	0.418			NA											7	66					0	0	0.00308	0	0
PSKH2	85481	broad.mit.edu	37	8	87076709	87076709	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr8:87076709G>A	uc011lfy.1	-	2	337	c.337C>T	c.(337-339)CGG>TGG	p.R113W		NM_033126	NP_149117	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	113	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|lung(2)|ovary(1)	5			STAD - Stomach adenocarcinoma(118;0.129)			CTAACCCGCCGCAGGACGCTC	0.507			NA											13	90					0	0	0.001216	0	0
CPNE3	8895	broad.mit.edu	37	8	87544779	87544779	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr8:87544779G>C	uc003ydv.2	+	6	592	c.430G>C	c.(430-432)GAA>CAA	p.E144Q		NM_003909	NP_003900	O75131	CPNE3_HUMAN	copine III	144	C2 2.				lipid metabolic process|vesicle-mediated transport	cytosol	calcium-dependent phospholipid binding|protein serine/threonine kinase activity|transporter activity			ovary(1)|skin(1)	2						GGTCTTGTTTGAAATGGAAGC	0.318			NA											4	273					0	0	0.000248	0	0
RGS22	26166	broad.mit.edu	37	8	100994288	100994288	+	Silent	SNP	A	A	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr8:100994288A>G	uc003yjb.1	-	22	3432	c.3237T>C	c.(3235-3237)ATT>ATC	p.I1079I	RGS22_uc003yja.1_Silent_p.I898I|RGS22_uc003yjc.1_Silent_p.I1067I	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	1079	RGS 2.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			AGCAGTTGATAATAGTTGTAA	0.373			NA											30	87					0	0	0.007291	0	0
UBR5	51366	broad.mit.edu	37	8	103289239	103289239	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr8:103289239C>T	uc003ykr.1	-	45	6503	c.6470G>A	c.(6469-6471)GGA>GAA	p.G2157E	UBR5_uc003yks.1_Missense_Mutation_p.G2157E	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2157					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TTCAGTAAGTCCTATTTCTGC	0.408	Ovarian(131;96 1741 5634 7352 27489)		NA											11	96					0	0	0.000673	0	0
RSPO2	340419	broad.mit.edu	37	8	108970419	108970419	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr8:108970419G>C	uc003yms.2	-	5	1163	c.505C>G	c.(505-507)CTG>GTG	p.L169V	RSPO2_uc003ymq.2_Missense_Mutation_p.L102V|RSPO2_uc003ymr.2_Missense_Mutation_p.L105V	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	R-spondin family, member 2 precursor	169	TSP type-1.				Wnt receptor signaling pathway	extracellular region	heparin binding			skin(3)|ovary(2)|pancreas(1)|lung(1)	7			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			CTGGTTTCCAGACCCCATTTA	0.408			NA											4	159					0	0	0.000248	0	0
EFR3A	23167	broad.mit.edu	37	8	132958769	132958769	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr8:132958769C>T	uc003yte.2	+	4	456	c.255C>T	c.(253-255)CTC>CTT	p.L85L		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	85						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			ACCAACTTCTCATGGCTTGCC	0.418			NA											5	36					0	0	0.000602	0	0
FAM135B	51059	broad.mit.edu	37	8	139144882	139144882	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr8:139144882A>G	uc003yuy.2	-	20	4346	c.4175T>C	c.(4174-4176)TTC>TCC	p.F1392S	FAM135B_uc003yux.2_Missense_Mutation_p.F1293S|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1392								p.F1392S(2)		ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CTTCTCCAGGAAGAGTTCTGA	0.522			NA								HNSCC(54;0.14)			5	265					0	0	0.001168	0	0
ZNF623	9831	broad.mit.edu	37	8	144733502	144733502	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr8:144733502A>G	uc003yzd.2	+	1	1549	c.1460A>G	c.(1459-1461)TAT>TGT	p.Y487C	ZNF623_uc011lkp.1_Missense_Mutation_p.Y447C|ZNF623_uc003yzc.2_Missense_Mutation_p.Y447C	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	487					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GAGAAGCTCTATGAATGTAGT	0.403			NA											27	65					0	0	0.004656	0	0
PPP1R16A	84988	broad.mit.edu	37	8	145724389	145724389	+	Silent	SNP	C	C	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr8:145724389C>T	uc003zdd.2	+	4	1334	c.421C>T	c.(421-423)CTG>TTG	p.L141L	uc003zde.1_5'Flank|PPP1R16A_uc003zdf.2_Silent_p.L141L	NM_032902	NP_116291	Q96I34	PP16A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	141	ANK 3.					plasma membrane	protein binding				0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CTGGACGCCTCTGCATGCTGC	0.622			NA											6	51					0	0	0.001168	0	0
SLC28A3	64078	broad.mit.edu	37	9	86903009	86903009	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr9:86903009C>G	uc010mpz.2	-	12	1359	c.1234G>C	c.(1234-1236)GAA>CAA	p.E412Q	SLC28A3_uc011lsy.1_Missense_Mutation_p.E343Q|SLC28A3_uc004anu.1_Missense_Mutation_p.E412Q	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	412	Extracellular (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						TTAGGTTTTTCTGTCTCAGGC	0.463	Ovarian(106;425 1539 34835 42413 43572)		NA											5	130					0	0	0.000602	0	0
SH3KBP1	30011	broad.mit.edu	37	X	19560190	19560190	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chrX:19560190C>G	uc004czm.2	-	16	2061	c.1745G>C	c.(1744-1746)GGA>GCA	p.G582A	SH3KBP1_uc011mje.1_Missense_Mutation_p.G321A|SH3KBP1_uc011mjf.1_Missense_Mutation_p.G344A|SH3KBP1_uc004czl.2_Missense_Mutation_p.G545A|SH3KBP1_uc010nfm.2_Missense_Mutation_p.G27A	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	582					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						GGCTCTGTGTCCAGCTGTTCC	0.667			NA											14	32					0	0	0.00245	0	0
FAM104B	90736	broad.mit.edu	37	X	55170248	55170248	+	Silent	SNP	G	G	C			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chrX:55170248G>C	uc004duh.1	-	4	332	c.312C>G	c.(310-312)CTC>CTG	p.L104L	FAM104B_uc004dug.1_Silent_p.L105L	NM_138362	NP_612371	Q5XKR9	F104B_HUMAN	hypothetical protein LOC90736	104											0						GTGAAGTATTGAGTTTTATTT	0.348			NA											24	75					0	0	0.004656	0	0
MAGEE1	57692	broad.mit.edu	37	X	75648398	75648398	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chrX:75648398G>T	uc004ecm.1	+	1	282	c.75G>T	c.(73-75)TGG>TGT	p.W25C		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	25						dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						ACAGCAGCTGGGGCGAAATGC	0.562			NA											7	2					1.6384e-10	2.68667e-10	0.001984	1	0
KLHL4	56062	broad.mit.edu	37	X	86921487	86921487	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chrX:86921487A>G	uc004efb.2	+	11	2292	c.2110A>G	c.(2110-2112)AAC>GAC	p.N704D	KLHL4_uc004efa.2_Intron	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	704	Kelch 6.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						AGTTCCTGTTAACATTGGAAG	0.318			NA											3	39					0	0	0.004672	0	0
KLHL13	90293	broad.mit.edu	37	X	117079539	117079539	+	Splice_Site	SNP	C	C	G			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chrX:117079539C>G	uc004eql.2	-	2	161	c.99_splice	c.e2-1	p.I33_splice	KLHL13_uc004eqk.2_5'UTR|KLHL13_uc011mtn.1_Splice_Site|KLHL13_uc011mto.1_Splice_Site_p.R27_splice|KLHL13_uc011mtp.1_Splice_Site_p.G35_splice|KLHL13_uc004eqm.2_Splice_Site|KLHL13_uc011mtq.1_Splice_Site_p.R17_splice	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13						cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						CACGAGAGATCTGAAAGTTTT	0.378			NA											5	13					0	0	0.001168	0	0
IGSF1	3547	broad.mit.edu	37	X	130420592	130420592	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chrX:130420592C>A	uc004ewd.2	-	2	295	c.57G>T	c.(55-57)TTG>TTT	p.L19F	IGSF1_uc004ewe.3_Missense_Mutation_p.L8F|IGSF1_uc004ewf.2_Missense_Mutation_p.L8F|IGSF1_uc004ewg.2_Missense_Mutation_p.L19F	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	19					regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						TGCAAAAGAGCAAAACAGTGA	0.527			NA											5	41					0.000602214	0.000902018	0.000602	1	0
PCDH11Y	83259	broad.mit.edu	37	Y	4968620	4968620	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chrY:4968620G>A	uc004fqo.2	+	2	3735	c.3001G>A	c.(3001-3003)GAT>AAT	p.D1001N	PCDH11Y_uc010nwg.1_Missense_Mutation_p.D990N|PCDH11Y_uc004fql.1_Missense_Mutation_p.D990N|PCDH11Y_uc004fqm.1_Missense_Mutation_p.D990N|PCDH11Y_uc004fqn.1_Missense_Mutation_p.D1001N|PCDH11Y_uc004fqp.1_Missense_Mutation_p.D772N	NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	1001	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						ACTGCCTCTCGATAACACCTT	0.498			NA											6	128					0	0	0.001984	0	0
OR10Z1	128368	broad.mit.edu	37	1	158577073	158577073	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr1:158577073delC	uc010pio.1	+	1	845	c.845delC	c.(844-846)ACCfs	p.T282fs		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					ACTGTAGTGACCCCCCTCCTT	0.458			NA											21	284	---	---	---	---	NA	NA	NA	NA	NA
WAPAL	23063	broad.mit.edu	37	10	88213425	88213442	+	In_Frame_Del	DEL	TTAAATTAAGCAACACCC	TTAAATTAAGCAACACCC	-			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	TTAAATTAAGCAACACCC	TTAAATTAAGCAACACCC	-	-	TTAAATTAAGCAACACCC	TTAAATTAAGCAACACCC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr10:88213425_88213442delTTAAATTAAGCAACACCC	uc001kdo.2	-	13	3246_3263	c.2804_2821delGGGTGTTGCTTAATTTAA	c.(2803-2823)GGGGTGTTGCTTAATTTAACT>GCT	p.935_941GVLLNLT>A	WAPAL_uc009xsv.2_In_Frame_Del_p.249_255GVLLNLT>A|WAPAL_uc001kdn.2_In_Frame_Del_p.972_978GVLLNLT>A|WAPAL_uc009xsw.2_In_Frame_Del_p.929_935GVLLNLT>A	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	935_941	WAPL.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						TTATCATTAGTTAAATTAAGCAACACCCCGATGATGGC	0.394			NA											9	96	---	---	---	---	NA	NA	NA	NA	NA
NCOR2	9612	broad.mit.edu	37	12	124957515	124957516	+	Frame_Shift_Ins	INS	-	-	A			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr12:124957515_124957516insA	uc010tba.1	-	4	690_691	c.573_574insT	c.(571-576)TCTAAGfs	p.S191fs	NCOR2_uc010tay.1_Frame_Shift_Ins_p.S191fs|NCOR2_uc010taz.1_Frame_Shift_Ins_p.S191fs|NCOR2_uc010tbb.1_Frame_Shift_Ins_p.S191fs|NCOR2_uc010tbc.1_Frame_Shift_Ins_p.S191fs|NCOR2_uc001ugj.1_Frame_Shift_Ins_p.S191fs|NCOR2_uc001ugk.1_Frame_Shift_Ins_p.S191fs	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	191_192	Potential.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TTCTTCAGCTTAGAGATCTGCT	0.574			NA											22	186	---	---	---	---	NA	NA	NA	NA	NA
MGA	23269	broad.mit.edu	37	15	42042623	42042629	+	Frame_Shift_Del	DEL	ACTTACT	ACTTACT	-			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	ACTTACT	ACTTACT	-	-	ACTTACT	ACTTACT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr15:42042623_42042629delACTTACT	uc010ucy.1	+	17	6999_7005	c.6818_6824delACTTACT	c.(6817-6825)CACTTACTGfs	p.H2273fs	MGA_uc010ucz.1_Frame_Shift_Del_p.H2064fs|MGA_uc010uda.1_Frame_Shift_Del_p.H889fs|MGA_uc001zoi.2_Frame_Shift_Del_p.H487fs	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2234_2236	Basic motif.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TTTCAGGGTCACTTACTGCTACCTGGA	0.44			NA											12	42	---	---	---	---	NA	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7574012	7574012	+	Frame_Shift_Del	DEL	C	C	-	rs17882252		TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr17:7574012delC	uc002gim.2	-	10	1209	c.1015delG	c.(1015-1017)GAGfs	p.E339fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Frame_Shift_Del_p.E207fs|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Frame_Shift_Del_p.E339fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	339	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Nuclear export signal.|Interaction with HIPK2.		E -> Q (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E339*(10)|p.0?(7)|p.E339fs*8(2)|p.E339Q(1)|p.?(1)|p.F338fs*6(1)|p.F338_E339>L(1)|p.E339fs*13(1)|p.I332fs*5(1)|p.E339K(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGAACATCTCGAAGCGCTCA	0.468	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	33	---	---	---	---	NA	NA	NA	NA	NA
TPTE	7179	broad.mit.edu	37	21	10944697	10944697	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr21:10944697delA	uc002yip.1	-	11	905	c.537delT	c.(535-537)TTTfs	p.F179fs	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Frame_Shift_Del_p.F161fs|TPTE_uc002yir.1_Frame_Shift_Del_p.F141fs|TPTE_uc010gkv.1_Frame_Shift_Del_p.F41fs	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	179	Helical; (Potential).				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACTTAATGTCAAAAAAAATGT	0.299			NA											8	310	---	---	---	---	NA	NA	NA	NA	NA
WBSCR28	135886	broad.mit.edu	37	7	73280192	73280193	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:73280192_73280193delCC	uc003tzk.2	+	3	823_824	c.787_788delCC	c.(787-789)CCCfs	p.P263fs	RFC2_uc011kfa.1_Intron|WBSCR28_uc003tzl.2_Frame_Shift_Del_p.P162fs	NM_182504	NP_872310	Q6UE05	WBS28_HUMAN	hypothetical protein LOC135886	263						integral to membrane				breast(1)	1		Lung NSC(55;0.159)				GCAAGAAACTCCCAGAGAATAA	0.54			NA											21	147	---	---	---	---	NA	NA	NA	NA	NA
PCLO	27445	broad.mit.edu	37	7	82544361	82544361	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr7:82544361delA	uc003uhx.2	-	7	13230	c.12941delT	c.(12940-12942)CTAfs	p.L4314fs	PCLO_uc003uhv.2_Frame_Shift_Del_p.L4314fs|PCLO_uc010lec.2_Frame_Shift_Del_p.L1279fs	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4245	Ser-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTTCAGTCTTAGGGAAGAGCT	0.378			NA											7	38	---	---	---	---	NA	NA	NA	NA	NA
DAPK1	1612	broad.mit.edu	37	9	90315030	90315037	+	Splice_Site	DEL	AGGTTTGG	AGGTTTGG	-			TCGA-55-6712-01A-11D-1855-08	TCGA-55-6712-10A-01D-1855-08	AGGTTTGG	AGGTTTGG	-	-	AGGTTTGG	AGGTTTGG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bc6eaf2b-9ccc-4ac7-9b19-204b0ff420a3	46dd81ba-62e9-42bb-8a84-461d79531d24	g.chr9:90315030_90315037delAGGTTTGG	uc004apc.2	+	24	2889	c.2751_splice	c.e24-1	p.R917_splice	DAPK1_uc004apd.2_Splice_Site_p.R917_splice|DAPK1_uc011ltg.1_Splice_Site_p.R851_splice|DAPK1_uc011lth.1_Splice_Site_p.R654_splice	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1						apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						CTCTTCCCTTAGGTTTGGAAATGATCTT	0.49			NA							Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				11	82	---	---	---	---	NA	NA	NA	NA	NA
