Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HSPG2	3339	broad.mit.edu	37	1	22179193	22179193	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr1:22179193C>A	uc001bfj.2	-	52	6764	c.6724G>T	c.(6724-6726)GGA>TGA	p.G2242*	HSPG2_uc009vqd.2_Nonsense_Mutation_p.G2243*	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2242	Ig-like C2-type 7.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	AGTCACTCACCAGGGATGACA	0.637			NA											27	161					1.88708e-17	2.96823e-17	0.008361	1	0
DAB1	1600	broad.mit.edu	37	1	57480716	57480716	+	Silent	SNP	G	G	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr1:57480716G>A	uc001cys.1	-	14	1958	c.1284C>T	c.(1282-1284)TCC>TCT	p.S428S	DAB1_uc001cyt.1_Silent_p.S426S|DAB1_uc001cyq.1_Silent_p.S426S|DAB1_uc001cyr.1_Silent_p.S342S|DAB1_uc009vzw.1_Silent_p.S410S|DAB1_uc009vzx.1_Silent_p.S428S	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	461					cell differentiation|nervous system development					skin(2)|ovary(1)	3						CGGGTTTGCGGGAGGGCACGG	0.567			NA											3	81					0	0	0.009096	0	0
TTLL7	79739	broad.mit.edu	37	1	84373239	84373239	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr1:84373239C>T	uc001djc.2	-	16	2288	c.1892G>A	c.(1891-1893)CGG>CAG	p.R631Q	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_RNA|TTLL7_uc001djf.2_RNA|TTLL7_uc001djg.2_RNA	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	631					cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		AGAAGTTGGCCGTGACACAGA	0.507			NA											4	105					0	0	0.009096	0	0
CLCA1	1179	broad.mit.edu	37	1	86951243	86951243	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr1:86951243C>T	uc001dlt.2	+	6	1082	c.953C>T	c.(952-954)GCG>GTG	p.A318V	CLCA1_uc001dls.1_Missense_Mutation_p.A257V	NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	318	VWFA.				calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		GGAAGCATGGCGGTATGTTCA	0.468			NA											11	138					0	0	0.00245	0	0
KCNA3	3738	broad.mit.edu	37	1	111216622	111216622	+	Silent	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr1:111216622C>A	uc001dzv.1	-	1	1034	c.810G>T	c.(808-810)TCG>TCT	p.S270S		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	270						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATGAGTCCTGCGACGTCGAGG	0.622			NA											17	76					1.99824e-07	2.49367e-07	0.00499	1	0
TRIM33	51592	broad.mit.edu	37	1	114940316	114940316	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr1:114940316C>T	uc001eew.2	-	20	3422	c.3338G>A	c.(3337-3339)CGC>CAC	p.R1113H	TRIM33_uc010owr.1_Missense_Mutation_p.R727H|TRIM33_uc010ows.1_Missense_Mutation_p.R745H|TRIM33_uc001eex.2_Missense_Mutation_p.R1096H	NM_015906	NP_056990	Q9UPN9	TRI33_HUMAN	tripartite motif-containing 33 protein isoform	1113					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			lung(4)|central_nervous_system(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	11	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCGTTTTCTGCGGGGCTGTAT	0.363			NA	T	RET	papillary thyroid								4	141					0	0	0.000602	0	0
NBPF10	100132406	broad.mit.edu	37	1	145295453	145295453	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr1:145295453T>G	uc001end.3	+	2	241	c.206T>G	c.(205-207)TTT>TGT	p.F69C	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.F69C|NOTCH2NL_uc010oyh.1_RNA|NBPF10_uc001emq.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	69											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CTCATAAAATTTATGCTGAGG	0.532			NA											3	112					0	0	0.004672	0	0
BCL9	607	broad.mit.edu	37	1	147084715	147084715	+	Silent	SNP	T	T	C			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr1:147084715T>C	uc001epq.2	+	5	827	c.87T>C	c.(85-87)CGT>CGC	p.R29R	BCL9_uc010ozr.1_Silent_p.R29R	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	29					Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					TGATGGTCCGTCCCCCTACAG	0.502			NA	T	IGH@|IGL@	B-ALL								3	141					0	0	0.009096	0	0
ARNT	405	broad.mit.edu	37	1	150807080	150807080	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr1:150807080T>C	uc001evr.1	-	8	880	c.737A>G	c.(736-738)AAG>AGG	p.K246R	ARNT_uc001evs.1_Missense_Mutation_p.K231R|ARNT_uc009wmb.1_Missense_Mutation_p.K237R|ARNT_uc009wmc.1_Missense_Mutation_p.K246R|ARNT_uc009wmd.1_Missense_Mutation_p.K231R|ARNT_uc009wme.1_Missense_Mutation_p.K246R|ARNT_uc010pcl.1_Missense_Mutation_p.K230R	NM_001668	NP_001659	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	246					positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			skin(4)|lung(3)|central_nervous_system(1)|kidney(1)	9	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTGACCTTCCTTTTTCACTGT	0.463			NA	T	ETV6	AML								3	174					0	0	0.009096	0	0
FLG	2312	broad.mit.edu	37	1	152275555	152275555	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr1:152275555T>A	uc001ezu.1	-	3	11843	c.11807A>T	c.(11806-11808)CAA>CTA	p.Q3936L		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3936	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGCAGAATCTTGTGAAAGACT	0.453			NA							Ichthyosis				19	84					0	0	0.010504	0	0
TNN	63923	broad.mit.edu	37	1	175054540	175054540	+	Splice_Site	SNP	G	G	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr1:175054540G>T	uc001gkl.1	+	6	1348	c.1235_splice	c.e6-1	p.G412_splice	TNN_uc010pmx.1_Splice_Site_p.G412_splice	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor						cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CTTGTTTCCAGGTCTGCACCC	0.597			NA											3	27					0.004672	0.00507534	0.004672	1	0
DISP1	84976	broad.mit.edu	37	1	223178305	223178305	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr1:223178305A>C	uc001hnu.1	+	8	3713	c.3566A>C	c.(3565-3567)CAT>CCT	p.H1189P		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1189					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		GAACTGGAGCATGAGTTTTAT	0.453			NA											11	55					0	0	0.013537	0	0
ITPKB	3707	broad.mit.edu	37	1	226923355	226923355	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr1:226923355G>A	uc010pvo.1	-	2	2145	c.1805C>T	c.(1804-1806)TCG>TTG	p.S602L	ITPKB_uc001hqh.2_Missense_Mutation_p.S602L	NM_002221	NP_002212	P27987	IP3KB_HUMAN	1D-myo-inositol-trisphosphate 3-kinase B	602	Poly-Ser.						ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			ovary(4)|central_nervous_system(1)	5		Prostate(94;0.0773)				GGAGGAGGCCGAGGAAGAGGA	0.612	Colon(84;110 1851 5306 33547)		NA											3	58					0	0	0.004672	0	0
FMN2	56776	broad.mit.edu	37	1	240635673	240635673	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr1:240635673G>C	uc010pyd.1	+	17	5287	c.5062G>C	c.(5062-5064)GTA>CTA	p.V1688L	FMN2_uc010pye.1_Missense_Mutation_p.V1692L|FMN2_uc010pyg.1_Missense_Mutation_p.V284L|FMN2_uc001hyr.2_RNA	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1688	Potential.|FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCCCATCAGAGTAAAAGAAGC	0.333			NA											3	83					0	0	0.009096	0	0
KMO	8564	broad.mit.edu	37	1	241714278	241714278	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr1:241714278G>T	uc009xgp.2	+	4	311	c.246G>T	c.(244-246)ATG>ATT	p.M82I	KMO_uc001hyy.2_Missense_Mutation_p.M82I|KMO_uc009xgo.1_Missense_Mutation_p.M82I	NM_003679	NP_003670	O15229	KMO_HUMAN	kynurenine 3-monooxygenase	82					pyridine nucleotide biosynthetic process|response to salt stress	cytosol|integral to membrane|mitochondrial outer membrane	electron carrier activity|flavin adenine dinucleotide binding|kynurenine 3-monooxygenase activity|NAD(P)H oxidase activity			ovary(2)	2	Ovarian(103;0.103)|all_lung(81;0.23)		OV - Ovarian serous cystadenocarcinoma(106;0.0176)			GTATTCCCATGAGAGCAAGAA	0.378			NA											52	193					1.55088e-19	2.54547e-19	0.01441	1	0
PRKCQ	5588	broad.mit.edu	37	10	6540402	6540402	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr10:6540402G>C	uc001ijj.1	-	5	573	c.498C>G	c.(496-498)TTC>TTG	p.F166L	PRKCQ_uc009xim.1_Missense_Mutation_p.F166L|PRKCQ_uc001iji.1_Missense_Mutation_p.F199L|PRKCQ_uc009xin.1_Missense_Mutation_p.F130L|PRKCQ_uc010qax.1_Missense_Mutation_p.F41L	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	166	Phorbol-ester/DAG-type 1.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						GCTGTGGGAAGAAGGTGGCAG	0.522	Ovarian(50;572 1126 10530 25349 30594)		NA											23	127					0	0	0.010818	0	0
CUBN	8029	broad.mit.edu	37	10	16990602	16990602	+	Missense_Mutation	SNP	C	C	T	rs145880377		TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr10:16990602C>T	uc001ioo.2	-	35	5136	c.5084G>A	c.(5083-5085)CGT>CAT	p.R1695H		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1695	CUB 11.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GCCACAGTAACGGCCTAAATA	0.473			NA											3	28					0	0	0.009096	0	0
ARHGAP12	94134	broad.mit.edu	37	10	32099639	32099639	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr10:32099639T>A	uc001ivz.1	-	16	2258	c.1988A>T	c.(1987-1989)CAG>CTG	p.Q663L	ARHGAP12_uc001ivy.1_Missense_Mutation_p.Q609L|ARHGAP12_uc009xls.2_Missense_Mutation_p.Q614L|ARHGAP12_uc001iwb.1_Missense_Mutation_p.Q656L|ARHGAP12_uc001iwc.1_Missense_Mutation_p.Q631L|ARHGAP12_uc009xlq.1_Missense_Mutation_p.Q584L|ARHGAP12_uc001ivw.1_5'Flank|ARHGAP12_uc001ivx.1_5'Flank	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	663	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				ATTCTCTCTCTGACACAGATT	0.318			NA											32	124					0	0	0.01441	0	0
B4GALNT4	338707	broad.mit.edu	37	11	381703	381703	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr11:381703C>T	uc001lpb.2	+	20	3040	c.3031C>T	c.(3031-3033)CGA>TGA	p.R1011*		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	1011	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGAGCGGCTCCGACTGCGGAA	0.682			NA											7	89					0	0	0.004482	0	0
NELL1	4745	broad.mit.edu	37	11	21250897	21250897	+	Silent	SNP	C	C	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr11:21250897C>T	uc001mqe.2	+	14	1599	c.1446C>T	c.(1444-1446)AGC>AGT	p.S482S	NELL1_uc001mqf.2_Silent_p.S482S|NELL1_uc009yid.2_Silent_p.S510S|NELL1_uc010rdo.1_Silent_p.S425S|NELL1_uc010rdp.1_Silent_p.S242S	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	482	EGF-like 3.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						AATGTGGCAGCGGCCAGCACA	0.488			NA											17	71					0	0	0.00278	0	0
OR4C16	219428	broad.mit.edu	37	11	55339695	55339695	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr11:55339695G>A	uc010rih.1	+	1	92	c.92G>A	c.(91-93)CGT>CAT	p.R31H		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				ATTTTTTTGCGTCTCTACTTG	0.368			NA											5	111					0	0	0.008291	0	0
FADS1	3992	broad.mit.edu	37	11	61580035	61580035	+	Silent	SNP	G	G	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr11:61580035G>A	uc010rlm.1	-	3	720	c.592C>T	c.(592-594)CTG>TTG	p.L198L	FADS1_uc001nsh.2_Silent_p.L57L|FADS1_uc010rln.1_Silent_p.L57L	NM_013402	NP_037534	O60427	FADS1_HUMAN	fatty acid desaturase 1	141	Helical; (Potential).				cell-cell signaling|cellular response to starvation|electron transport chain|icosanoid biosynthetic process|phospholipid biosynthetic process|regulation of cell differentiation|regulation of transcription, DNA-dependent|transport	endoplasmic reticulum membrane|integral to membrane|microsome	C-5 sterol desaturase activity|heme binding|protein binding			central_nervous_system(1)	1					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CCATCCAGCAGCAAGATGTGC	0.592			NA											3	68					0	0	0.000602	0	0
PPP2R5B	5526	broad.mit.edu	37	11	64695896	64695896	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr11:64695896C>T	uc001oby.2	+	6	1306	c.721C>T	c.(721-723)CGG>TGG	p.R241W	PPP2R5B_uc001obz.2_Missense_Mutation_p.R241W	NM_006244	NP_006235	Q15173	2A5B_HUMAN	beta isoform of regulatory subunit B56, protein	241					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(2)	2						CATCTTCCTCCGGTGAGTGGC	0.517			NA											4	126					0	0	0.000602	0	0
DPP3	10072	broad.mit.edu	37	11	66258810	66258810	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr11:66258810G>C	uc001oig.1	+	7	816	c.754G>C	c.(754-756)GCG>CCG	p.A252P	DPP3_uc001oif.1_Missense_Mutation_p.A252P|DPP3_uc010rpe.1_Missense_Mutation_p.A241P	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	252					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						GGGGGACTACGCGCCCATCCT	0.627			NA									OREG0021109	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	93					0	0	0.008871	0	0
CTTN	2017	broad.mit.edu	37	11	70279299	70279299	+	Silent	SNP	C	C	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr11:70279299C>T	uc001opv.3	+	16	1565	c.1359C>T	c.(1357-1359)TAC>TAT	p.Y453Y	CTTN_uc001opu.2_Silent_p.Y416Y|CTTN_uc001opw.3_Silent_p.Y416Y|CTTN_uc010rqm.1_Silent_p.Y137Y|CTTN_uc001opx.2_Silent_p.Y137Y	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	453						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		CCGCTGACTACCGAGAGGCCA	0.657			NA											7	44					0	0	0.006214	0	0
FAT3	120114	broad.mit.edu	37	11	92533638	92533638	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr11:92533638C>T	uc001pdj.3	+	9	7476	c.7459C>T	c.(7459-7461)CTT>TTT	p.L2487F		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2487	Cadherin 22.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TATTAGGGTACTTGGGGCTAA	0.507			NA								TCGA Ovarian(4;0.039)			17	51					0	0	0.006122	0	0
LRP6	4040	broad.mit.edu	37	12	12279682	12279682	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr12:12279682C>A	uc001rah.3	-	20	4397	c.4255G>T	c.(4255-4257)GCT>TCT	p.A1419S	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.A1374S	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	1419	Cytoplasmic (Potential).				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				GGCACAGAAGCTGGTCCATGA	0.458			NA											27	107					7.11191e-15	1.08475e-14	0.013726	1	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr12:25398284C>A	uc001rgp.1	-	2	216	c.35G>T	c.(34-36)GGT>GTT	p.G12V	KRAS_uc001rgq.1_Missense_Mutation_p.G12V|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			21	28					3.73148e-12	5.36622e-12	0.007291	1	0
MLL2	8085	broad.mit.edu	37	12	49434727	49434727	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr12:49434727G>A	uc001rta.3	-	31	6826	c.6826C>T	c.(6826-6828)CCA>TCA	p.P2276S		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2276	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCAAAAGGTGGGGGCGAGAGC	0.622			NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			34	46					0	0	0.004878	0	0
KCNH3	23416	broad.mit.edu	37	12	49951615	49951615	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr12:49951615C>A	uc001ruh.1	+	15	3391	c.3131C>A	c.(3130-3132)CCC>CAC	p.P1044H	KCNH3_uc010smj.1_Missense_Mutation_p.P984H	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	1044	Pro-rich.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						ACTGGAGAGCCCCCACCAGGG	0.677			NA											8	48					0.000274275	0.000311395	0.004482	1	0
PLA2G1B	5319	broad.mit.edu	37	12	120765547	120765547	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr12:120765547G>T	uc001tyd.2	-	1	46	c.10C>A	c.(10-12)CTT>ATT	p.L4I	PLA2G1B_uc009zwx.2_Missense_Mutation_p.L4I	NM_000928	NP_000919	P04054	PA21B_HUMAN	phospholipase A2 group IB precursor	4					actin filament organization|activation of MAPK activity|activation of phospholipase A2 activity|arachidonic acid secretion|cellular response to insulin stimulus|glucose transport|interleukin-8 production|leukotriene biosynthetic process|multicellular organismal lipid catabolic process|neutrophil chemotaxis|neutrophil mediated immunity|phosphatidylcholine metabolic process|positive regulation of calcium ion transport into cytosol|positive regulation of DNA replication|positive regulation of immune response|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein secretion|positive regulation of transcription from RNA polymerase II promoter	extracellular space	bile acid binding|calcium ion binding|calcium-dependent phospholipase A2 activity|cell surface binding|receptor binding			skin(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCTAGCACAAGGAGTTTCATC	0.527	NSCLC(64;1781 1795 22266 42732)|Esophageal Squamous(30;459 829 25326 35148)		NA											23	91					5.77227e-19	9.37218e-19	0.008361	1	0
GOLGA3	2802	broad.mit.edu	37	12	133384781	133384781	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr12:133384781C>A	uc001ukz.1	-	5	1433	c.874G>T	c.(874-876)GAC>TAC	p.D292Y	GOLGA3_uc001ula.1_Missense_Mutation_p.D292Y|GOLGA3_uc001ulb.2_Missense_Mutation_p.D292Y	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	292					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		TCGTCAGTGTCGGGGGACAGG	0.592			NA											32	116					8.4185e-14	1.24627e-13	0.012213	1	0
PARP4	143	broad.mit.edu	37	13	25023877	25023877	+	Silent	SNP	G	G	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr13:25023877G>A	uc001upl.2	-	25	3199	c.3093C>T	c.(3091-3093)TCC>TCT	p.S1031S		NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1031	VWFA.				cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		AACTATGCTTGGATTTTGCAT	0.333			NA											17	82					0	0	0.008871	0	0
OR4K1	79544	broad.mit.edu	37	14	20404299	20404299	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr14:20404299C>A	uc001vwj.1	+	1	474	c.474C>A	c.(472-474)AGC>AGA	p.S158R		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		ATTCTGTGAGCCACTTGGCTT	0.478			NA											26	63					4.59853e-10	6.25566e-10	0.005443	1	0
LTBP2	4053	broad.mit.edu	37	14	74973502	74973502	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr14:74973502G>C	uc001xqa.2	-	27	4319	c.3932C>G	c.(3931-3933)ACC>AGC	p.T1311S		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1311	Cys-rich.|EGF-like 15; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GCCACACATGGTGTCGTTGGC	0.463			NA											9	50					0	0	0.013537	0	0
NRXN3	9369	broad.mit.edu	37	14	79270063	79270063	+	Silent	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr14:79270063C>A	uc001xun.2	+	6	1517	c.1026C>A	c.(1024-1026)TCC>TCA	p.S342S	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Silent_p.S476S	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	715	Laminin G-like 4.|Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GCTTCATGTCCCAGCGAGCTT	0.557			NA											27	84					8.58068e-18	1.36388e-17	0.007291	1	0
KIAA1409	57578	broad.mit.edu	37	14	94139798	94139798	+	Silent	SNP	T	T	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr14:94139798T>A	uc001ybv.1	+	40	6473	c.6390T>A	c.(6388-6390)GTT>GTA	p.V2130V	KIAA1409_uc001ybs.1_Silent_p.V2108V	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2285						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TTCTGCTTGTTCAGGTAAGCT	0.373			NA											17	81					0	0	0.00499	0	0
C15orf2	23742	broad.mit.edu	37	15	24924367	24924367	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr15:24924367C>A	uc001ywo.2	+	1	3827	c.3353C>A	c.(3352-3354)GCT>GAT	p.A1118D		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	1118					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TGTGTTCCTGCTTTTCAACAG	0.488			NA											25	143					8.58068e-18	1.36388e-17	0.007291	1	0
SLC12A6	9990	broad.mit.edu	37	15	34529746	34529746	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr15:34529746C>A	uc001zhw.2	-	21	2972	c.2808G>T	c.(2806-2808)TGG>TGT	p.W936C	SLC12A6_uc001zhv.2_Missense_Mutation_p.W885C|SLC12A6_uc001zhx.2_Missense_Mutation_p.W921C|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Missense_Mutation_p.W877C|SLC12A6_uc001zib.2_Missense_Mutation_p.W927C|SLC12A6_uc001zic.2_Missense_Mutation_p.W936C|SLC12A6_uc010bau.2_Missense_Mutation_p.W936C|SLC12A6_uc001zid.2_Missense_Mutation_p.W877C|SLC12A6_uc001zht.2_RNA|SLC12A6_uc001zhu.2_Missense_Mutation_p.W748C	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	936	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	TGCACTTTCGCCACACCTGAG	0.418			NA											12	77					0.00316338	0.00348664	0.003163	1	0
PAQR5	54852	broad.mit.edu	37	15	69696075	69696075	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr15:69696075A>T	uc002arz.2	+	9	1285	c.907A>T	c.(907-909)ATC>TTC	p.I303F	PAQR5_uc002asa.2_Missense_Mutation_p.I303F	NM_017705	NP_060175	Q9NXK6	MPRG_HUMAN	progestin and adipoQ receptor family member V	303	Helical; Name=7; (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane	receptor activity|steroid binding			ovary(2)	2						ACTTCTGTGCATCATCTTCAG	0.458			NA											15	69					0	0	0.00499	0	0
SEPT12	124404	broad.mit.edu	37	16	4833675	4833675	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr16:4833675T>A	uc002cxq.2	-	6	746	c.605A>T	c.(604-606)GAG>GTG	p.E202V	SEPT12_uc002cxr.2_Missense_Mutation_p.E156V|SEPT12_uc010bty.2_RNA	NM_144605	NP_653206	Q8IYM1	SEP12_HUMAN	septin 12 isoform 2	202	GTP (By similarity).				cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			skin(1)	1						CTCTCGCTCCTCCATGGTCAG	0.687			NA											18	61					0	0	0.010504	0	0
COQ7	10229	broad.mit.edu	37	16	19088645	19088645	+	Silent	SNP	G	G	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr16:19088645G>A	uc002dfr.2	+	5	585	c.525G>A	c.(523-525)CGG>CGA	p.R175R	COQ7_uc002dfs.2_Silent_p.R161R	NM_016138	NP_057222	Q99807	COQ7_HUMAN	COQ7 protein	175	2.|2 X approximate tandem repeats.				ubiquinone biosynthetic process	mitochondrial inner membrane|nucleus	oxidoreductase activity|transition metal ion binding			skin(1)	1						AGAAATTTCGGGATGAAGAGC	0.448			NA											12	32					0	0	0.004007	0	0
SULT1A1	6817	broad.mit.edu	37	16	28619895	28619895	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr16:28619895T>A	uc002dqi.2	-	2	651	c.178A>T	c.(178-180)ATG>TTG	p.M60L	uc010vct.1_Intron|SULT1A1_uc002dqj.2_Missense_Mutation_p.M60L|SULT1A1_uc002dqk.2_Missense_Mutation_p.M60L|SULT1A1_uc002dql.2_Missense_Mutation_p.M60L|SULT1A1_uc002dqm.2_Intron|SULT1A1_uc002dqn.2_Missense_Mutation_p.M151L|SULT1A1_uc002dqo.2_Missense_Mutation_p.M60L|SULT1A1_uc002dqp.2_Missense_Mutation_p.M60L	NM_177534	NP_803878	P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A,	60					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity				0						TGGTAGATCATGTCCAGAATC	0.602			NA											4	41					0	0	0.00499	0	0
ITGAL	3683	broad.mit.edu	37	16	30532924	30532924	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr16:30532924G>C	uc002dyi.3	+	31	3627	c.3451G>C	c.(3451-3453)GAT>CAT	p.D1151H	ITGAL_uc002dyj.3_Missense_Mutation_p.D1067H|ITGAL_uc010vev.1_Missense_Mutation_p.D385H	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	1151	Cytoplasmic (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	AGAGGCTGGGGATCCCGGCTG	0.512	NSCLC(110;1462 1641 3311 33990 49495)		NA											18	87					0	0	0.00333	0	0
RFFL	117584	broad.mit.edu	37	17	33348651	33348651	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr17:33348651C>A	uc002hin.1	-	3	503	c.330G>T	c.(328-330)AGG>AGT	p.R110S	RFFL_uc002hiq.2_Intron|RFFL_uc002him.1_Missense_Mutation_p.R110S|RFFL_uc010cti.1_Missense_Mutation_p.R116S|RFFL_uc002hip.1_Missense_Mutation_p.R110S|RFFL_uc002hio.1_Missense_Mutation_p.R110S	NM_001017368	NP_001017368	Q8WZ73	RFFL_HUMAN	rififylin	110	SAP 1.				apoptosis	membrane	ligase activity|zinc ion binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		TGAGATAGTCCCTCAAGTCCT	0.552			NA											18	84					8.10497e-08	1.03716e-07	0.010504	1	0
KLHL11	55175	broad.mit.edu	37	17	40021265	40021265	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr17:40021265T>A	uc002hyf.1	-	1	365	c.359A>T	c.(358-360)GAG>GTG	p.E120V		NM_018143	NP_060613	Q9NVR0	KLH11_HUMAN	kelch-like 11 precursor	120	BTB.					extracellular region					0		Breast(137;0.00156)				CGTGAAGTACTCGGTGGCGGC	0.701			NA											6	34					0	0	0.001168	0	0
BZRAP1	9256	broad.mit.edu	37	17	56387946	56387946	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr17:56387946C>G	uc002ivx.3	-	20	4497	c.3626G>C	c.(3625-3627)CGG>CCG	p.R1209P	BZRAP1_uc010dcs.2_Missense_Mutation_p.R1149P|BZRAP1_uc010wnt.1_Missense_Mutation_p.R1209P	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1209						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGCTGGGCCCGTGCTCCCTG	0.672			NA											8	43					0	0	0.00308	0	0
CACNG1	786	broad.mit.edu	37	17	65040854	65040854	+	Silent	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr17:65040854C>A	uc002jfu.2	+	1	149	c.78C>A	c.(76-78)GCC>GCA	p.A26A		NM_000727	NP_000718	Q06432	CCG1_HUMAN	voltage-dependent calcium channel gamma-1	26	Helical; (Potential).				muscle contraction	voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(12;1.04e-10)|Breast(2;1.45e-16)|all_epithelial(3;4.81e-12)				Amlodipine(DB00381)|Diltiazem(DB00343)|Ibutilide(DB00308)|Lercanidipine(DB00528)|Magnesium Sulfate(DB00653)|Nimodipine(DB00393)|Nitrendipine(DB01054)|Verapamil(DB00661)	CCATGACAGCCGTGGTAACCG	0.632			NA											24	106					1.7881e-09	2.38941e-09	0.008361	1	0
DNAH17	8632	broad.mit.edu	37	17	76566359	76566359	+	Silent	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr17:76566359C>A	uc002jvv.1	-	3	226	c.120G>T	c.(118-120)CTG>CTT	p.L40L						RecName: Full=Dynein heavy chain 17, axonemal; AltName: Full=Axonemal beta dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain-like protein 1; AltName: Full=Axonemal dynein heavy chain-like protein 1; AltName: Full=Dynein light chain 2, axonemal;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			AGAACTCCTGCAGGATGACGA	0.587			NA											3	9					0.004672	0.00507534	0.004672	1	0
TUBB6	84617	broad.mit.edu	37	18	12325517	12325517	+	Silent	SNP	G	G	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr18:12325517G>A	uc002kqw.2	+	4	774	c.729G>A	c.(727-729)CCG>CCA	p.P243P	TUBB6_uc002kqv.2_Silent_p.P171P|TUBB6_uc010dld.2_RNA|TUBB6_uc002kqx.2_Silent_p.P206P|TUBB6_uc002kqy.2_Intron	NM_032525	NP_115914	Q9BUF5	TBB6_HUMAN	tubulin, beta 6	243					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0				READ - Rectum adenocarcinoma(1;0.0649)		TGCGCTTCCCGGGCCAGCTCA	0.657			NA											12	80					0	0	0.00245	0	0
GATA6	2627	broad.mit.edu	37	18	19751291	19751291	+	Silent	SNP	G	G	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr18:19751291G>T	uc002ktt.1	+	2	451	c.186G>T	c.(184-186)ACG>ACT	p.T62T	GATA6_uc002ktu.1_Silent_p.T62T	NM_005257	NP_005248	Q92908	GATA6_HUMAN	GATA binding protein 6	62					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(3)	3	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			ACTGCGGGACGCCTCAGCTCG	0.751	Colon(8;48 282 46199 46856)|Melanoma(177;170 2725 12489 26999)		NA											18	15					1.10513e-12	1.62015e-12	0.014323	1	0
CNDP2	55748	broad.mit.edu	37	18	72176088	72176088	+	Silent	SNP	G	G	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr18:72176088G>A	uc002llm.1	+	5	543	c.381G>A	c.(379-381)GGG>GGA	p.G127G	CNDP2_uc002lln.1_Intron|CNDP2_uc002llo.2_Silent_p.G127G|CNDP2_uc002llp.1_RNA|CNDP2_uc010dqs.2_5'Flank	NM_018235	NP_060705	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2	127						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			ovary(2)|skin(1)	3		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		AGCTGTATGGGAGAGGTTCGA	0.522			NA											7	34					0	0	0.008291	0	0
ADNP2	22850	broad.mit.edu	37	18	77894355	77894355	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr18:77894355G>T	uc002lnw.2	+	4	1514	c.1059G>T	c.(1057-1059)CAG>CAT	p.Q353H		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	353	Pro-rich.				cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		CAGCACCTCAGCCCGTCTTTC	0.582			NA											13	60					2.23348e-06	2.63481e-06	0.004007	1	0
HNRNPM	4670	broad.mit.edu	37	19	8528531	8528531	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr19:8528531C>A	uc010dwe.2	+	5	479	c.399C>A	c.(397-399)AAC>AAA	p.N133K	HNRNPM_uc010dwc.1_Missense_Mutation_p.N133K|HNRNPM_uc010xke.1_Missense_Mutation_p.N133K|HNRNPM_uc010dwd.2_Missense_Mutation_p.N133K|HNRNPM_uc002mka.2_Missense_Mutation_p.N13K	NM_005968	NP_005959	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	133	RRM 1.				alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding				0						AAGTCCTAAACAAGCATAGTC	0.418			NA											9	44					9.05144e-12	1.27735e-11	0.001855	1	0
ZNF699	374879	broad.mit.edu	37	19	9407173	9407173	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr19:9407173C>T	uc002mlc.1	-	5	907	c.907G>A	c.(907-909)GGA>AGA	p.G303R		NM_198535	NP_940937	Q32M78	ZN699_HUMAN	zinc finger protein 699	303					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGCTTATCTCCACTGTGAATT	0.393			NA											25	121					0	0	0.00632	0	0
FDX1L	112812	broad.mit.edu	37	19	10421212	10421212	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr19:10421212T>A	uc002mny.1	-	5	521	c.502A>T	c.(502-504)AAG>TAG	p.K168*	ZGLP1_uc002mnw.3_5'Flank|FDX1L_uc002mnx.1_RNA	NM_001031734	NP_001026904	Q6P4F2	ADXL_HUMAN	ferredoxin 1-like precursor	168	2Fe-2S ferredoxin-type.				electron transport chain|transport	mitochondrial matrix	2 iron, 2 sulfur cluster binding|electron carrier activity|metal ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(20;9.5e-10)|Epithelial(33;2.11e-06)|all cancers(31;5.06e-06)			CTGGTGATCTTGGGCAGGGTG	0.602			NA											7	67					0	0	0.001984	0	0
ZNF99	7652	broad.mit.edu	37	19	22939472	22939472	+	Missense_Mutation	SNP	A	A	G	rs55891931		TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr19:22939472A>G	uc010xrh.1	-	7	2699	c.2699T>C	c.(2698-2700)TTC>TCC	p.F900S		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AAGGGTCGAGAAATTGTTAAA	0.353			NA											3	88					0	0	0.004672	0	0
AXL	558	broad.mit.edu	37	19	41748808	41748808	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr19:41748808G>T	uc010ehj.2	+	11	1523	c.1333G>T	c.(1333-1335)GCC>TCC	p.A445S	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehi.1_Missense_Mutation_p.A445S|AXL_uc010ehk.2_Missense_Mutation_p.A436S	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	445	Extracellular (Potential).					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						TTCAACTCCTGCCTTCTCGTG	0.567			NA											17	81					4.96729e-08	6.46604e-08	0.008871	1	0
GRIK5	2901	broad.mit.edu	37	19	42509946	42509946	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr19:42509946C>T	uc002osj.1	-	16	2227	c.2192G>A	c.(2191-2193)CGC>CAC	p.R731H	GRIK5_uc002osi.1_Missense_Mutation_p.R303H	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	731	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	GCAGTTGAGGCGCCGGTGGTA	0.622			NA											8	42					0	0	0.008291	0	0
ZNF526	116115	broad.mit.edu	37	19	42730535	42730535	+	Silent	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr19:42730535C>A	uc002osz.1	+	3	2136	c.1980C>A	c.(1978-1980)GGC>GGA	p.G660G		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	660					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				GTGAAGCAGGCGGGCTCTTGC	0.597			NA											4	167					0.000602214	0.000673588	0.000602	1	0
ZNF404	342908	broad.mit.edu	37	19	44376838	44376838	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr19:44376838G>T	uc002oxs.3	-	2	1528	c.1519C>A	c.(1519-1521)CTT>ATT	p.L507I		NM_001033719	NP_001028891	Q494X3	ZN404_HUMAN	zinc finger protein 404	510	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				TGTTGAGTAAGTCGATCACTG	0.373			NA											6	33					2.0095e-06	2.40821e-06	0.001984	1	0
PRRG2	5639	broad.mit.edu	37	19	50093639	50093639	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr19:50093639C>T	uc002pon.3	+	7	767	c.602C>T	c.(601-603)CCT>CTT	p.P201L	PRRG2_uc010yaz.1_Missense_Mutation_p.P178L|PRR12_uc002poo.3_5'Flank	NM_000951	NP_000942	O14669	TMG2_HUMAN	proline rich Gla (G-carboxyglutamic acid) 2	201	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	calcium ion binding			skin(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0121)		CTCAGGAGGCCTCACTGAAGA	0.597			NA											43	186					0	0	0.01441	0	0
ZNF677	342926	broad.mit.edu	37	19	53740556	53740556	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr19:53740556C>T	uc002qbf.1	-	5	1609	c.1424G>A	c.(1423-1425)TGG>TAG	p.W475*	ZNF677_uc002qbg.1_Nonsense_Mutation_p.W475*	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	475	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)		CTGATGACCCCAAAGGTGTGA	0.363			NA											15	66					0	0	0.004007	0	0
PTPRH	5794	broad.mit.edu	37	19	55697831	55697831	+	Splice_Site	SNP	C	C	A	rs74901631	by1000genomes	TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr19:55697831C>A	uc002qjq.2	-	15	2716	c.2643_splice	c.e15+1	p.P881_splice	PTPRH_uc010esv.2_Splice_Site_p.P703_splice	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H						apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		CACGACCTTACGGGCATGAAG	0.587			NA											26	80					5.45727e-16	8.40865e-16	0.008361	1	0
OTOF	9381	broad.mit.edu	37	2	26686972	26686972	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr2:26686972G>T	uc002rhk.2	-	40	5090	c.4963C>A	c.(4963-4965)CAG>AAG	p.Q1655K	OTOF_uc010yla.1_Missense_Mutation_p.Q385K|OTOF_uc002rhh.2_Missense_Mutation_p.Q888K|OTOF_uc002rhi.2_Missense_Mutation_p.Q965K|OTOF_uc002rhj.2_Missense_Mutation_p.Q888K	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	1655	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCTTCCTCTGACCTGTGGGT	0.567	GBM(102;732 1451 20652 24062 31372)		NA											12	81					0.00316338	0.00348664	0.003163	1	0
ALK	238	broad.mit.edu	37	2	29455179	29455179	+	Missense_Mutation	SNP	C	C	T	rs148001139		TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr2:29455179C>T	uc002rmy.2	-	15	3530	c.2623G>A	c.(2623-2625)GGA>AGA	p.G875R		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	875	Gly-rich.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CCTGCGGCTCCGGAATTGCCG	0.617			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				34	123					0	0	0.004878	0	0
ALK	238	broad.mit.edu	37	2	29606679	29606679	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr2:29606679G>A	uc002rmy.2	-	5	2108	c.1201C>T	c.(1201-1203)CGA>TGA	p.R401*		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	401	MAM 1.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity	p.R401Q(1)|p.R401*(1)	NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	AGGGCCACTCGAAATGGGTTG	0.483			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				16	92					0	0	0.00499	0	0
SRD5A2	6716	broad.mit.edu	37	2	31805946	31805946	+	Silent	SNP	G	G	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr2:31805946G>A	uc002rnw.1	-	1	95	c.24C>T	c.(22-24)AGC>AGT	p.S8S		NM_000348	NP_000339	P31213	S5A2_HUMAN	3-oxo-5 alpha-steroid 4-dehydrogenase 2	8	Helical; (Potential).				androgen biosynthetic process|cell differentiation|cell-cell signaling|male gonad development	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|sterol 5-alpha reductase activity				0	Acute lymphoblastic leukemia(172;0.155)				Azelaic Acid(DB00548)|Dutasteride(DB01126)	CCAGCACTGGGCTCTGCTGGC	0.682			NA											8	29					0	0	0.013537	0	0
C2orf78	388960	broad.mit.edu	37	2	74043183	74043183	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr2:74043183A>T	uc002sjr.1	+	3	1954	c.1833A>T	c.(1831-1833)CAA>CAT	p.Q611H		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	611	Lys-rich.									ovary(2)	2						AGAAAAATCAACCTGAGCTTA	0.448			NA											9	49					0	0	0.006214	0	0
POU3F3	5455	broad.mit.edu	37	2	105472206	105472206	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr2:105472206G>T	uc010ywg.1	+	1	238	c.238G>T	c.(238-240)GGG>TGG	p.G80W		NM_006236	NP_006227	P20264	PO3F3_HUMAN	POU class 3 homeobox 3	80	Gly-rich.				metanephric ascending thin limb development|metanephric DCT cell differentiation|metanephric macula densa development|metanephric thick ascending limb development|negative regulation of apoptosis|positive regulation of cell proliferation	nucleus	sequence-specific DNA binding			ovary(1)	1						CTTCATGCAGGGGGCCATGGC	0.552			NA											5	17					0.000157383	0.000180037	0.00308	1	0
ACTR3	10096	broad.mit.edu	37	2	114685027	114685027	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr2:114685027C>G	uc002tkx.1	+	4	651	c.331C>G	c.(331-333)CTT>GTT	p.L111V	ACTR3_uc010yyc.1_Missense_Mutation_p.L49V|ACTR3_uc010yyd.1_Missense_Mutation_p.L60V	NM_005721	NP_005712	P61158	ARP3_HUMAN	ARP3 actin-related protein 3 homolog	111					cellular component movement|cilium morphogenesis	Arp2/3 protein complex	actin binding|ATP binding			skin(1)	1						CCATTATTTTCTTTTGGTAAG	0.308			NA											13	50					0	0	0.001855	0	0
TTN	7273	broad.mit.edu	37	2	179439161	179439161	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr2:179439161G>A	uc010zfg.1	-	275	64218	c.63994C>T	c.(63994-63996)CGG>TGG	p.R21332W	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R15027W|TTN_uc010zfi.1_Missense_Mutation_p.R14960W|TTN_uc010zfj.1_Missense_Mutation_p.R14835W	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22259							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAATCACCCGGAACTCATAA	0.453			NA											35	339					0	0	0.006999	0	0
CCDC150	284992	broad.mit.edu	37	2	197597246	197597246	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr2:197597246C>T	uc002utp.1	+	28	3401	c.3266C>T	c.(3265-3267)CCC>CTC	p.P1089L	CCDC150_uc010zgs.1_Missense_Mutation_p.P736L	NM_001080539	NP_001074008	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	1089											0						AATCTTAGGCCCATGCCCAAG	0.443			NA											34	160					0	0	0.010771	0	0
ERBB4	2066	broad.mit.edu	37	2	212295790	212295790	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr2:212295790A>T	uc002veg.1	-	21	2621	c.2523T>A	c.(2521-2523)CAT>CAA	p.H841Q	ERBB4_uc002veh.1_Missense_Mutation_p.H841Q|ERBB4_uc010zji.1_Missense_Mutation_p.H831Q|ERBB4_uc010zjj.1_Missense_Mutation_p.H831Q	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	841	Protein kinase.|Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CCAAATCCCGATGAACGAGTC	0.398			NA								TSP Lung(8;0.080)			10	127					0	0	0.001855	0	0
SLC11A1	6556	broad.mit.edu	37	2	219259426	219259426	+	Missense_Mutation	SNP	A	A	G	rs139317500	by1000genomes	TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr2:219259426A>G	uc002vhv.2	+	14	1800	c.1460A>G	c.(1459-1461)TAT>TGT	p.Y487C	SLC11A1_uc010zkc.1_Missense_Mutation_p.Y420C|SLC11A1_uc002vhu.1_Missense_Mutation_p.Y282C|SLC11A1_uc002vhw.2_Missense_Mutation_p.Y369C|SLC11A1_uc010fvr.2_Missense_Mutation_p.Y282C	NM_000578	NP_000569	P49279	NRAM1_HUMAN	natural resistance-associated macrophage protein	487	Helical; (Potential).				activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			ovary(3)|central_nervous_system(1)	4		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTGGTCAGCTATCTGCCCAGC	0.622			NA											28	135					0	0	0.012213	0	0
MSL3L2	151507	broad.mit.edu	37	2	234775527	234775527	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr2:234775527C>A	uc010znf.1	-	2	553	c.315G>T	c.(313-315)TTG>TTT	p.L105F		NR_024322				SubName: Full=cDNA FLJ52683, highly similar to Male-specific lethal 3-like 1; SubName: Full=cDNA, FLJ79271, highly similar to Male-specific lethal 3-like 1; SubName: Full=HCG1642047;												0						AGAGTAAAACCAACGGGAGAG	0.393			NA											7	47					7.48243e-07	9.11167e-07	0.006214	1	0
CHGB	1114	broad.mit.edu	37	20	5897563	5897563	+	Missense_Mutation	SNP	C	C	T	rs143107119		TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr20:5897563C>T	uc002wmg.2	+	3	494	c.188C>T	c.(187-189)ACG>ATG	p.T63M	CHGB_uc010zqz.1_Intron	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	63						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						GTCCTGAAGACGAGTAAGTGT	0.547			NA											24	84					0	0	0.005443	0	0
PAK7	57144	broad.mit.edu	37	20	9546720	9546720	+	Silent	SNP	C	C	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr20:9546720C>T	uc002wnl.2	-	6	1847	c.1302G>A	c.(1300-1302)GCG>GCA	p.A434A	PAK7_uc002wnk.2_Silent_p.A434A|PAK7_uc002wnj.2_Silent_p.A434A|PAK7_uc010gby.1_Silent_p.A434A	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	434	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			GCTGCAGGGCCGCCCGAAACT	0.632			NA											26	87					0	0	0.00333	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37547102	37547102	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr20:37547102C>G	uc002xje.2	+	11	1686	c.1497C>G	c.(1495-1497)AGC>AGG	p.S499R	PPP1R16B_uc010ggc.2_Missense_Mutation_p.S457R	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	499					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CCTTCCTTAGCACACACCTGG	0.632			NA											13	45					0	0	0.001855	0	0
PRIC285	85441	broad.mit.edu	37	20	62191918	62191918	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr20:62191918C>A	uc002yfm.2	-	17	8306	c.7414G>T	c.(7414-7416)GTG>TTG	p.V2472L	PRIC285_uc002yfl.1_Missense_Mutation_p.V1903L	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	2472					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			TGGCCCTGCACGTGGCCAAAG	0.632			NA											23	103					1.33986e-20	2.22329e-20	0.004656	1	0
ITPR1	3708	broad.mit.edu	37	3	4712560	4712560	+	Silent	SNP	G	G	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr3:4712560G>A	uc003bqa.2	+	20	2502	c.2154G>A	c.(2152-2154)CAG>CAA	p.Q718Q	ITPR1_uc010hca.1_Silent_p.Q703Q|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Silent_p.Q703Q	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	718	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AATTGGCTCAGGATGCTAAAG	0.552			NA											4	15					0	0	0.009096	0	0
SCAP	22937	broad.mit.edu	37	3	47476594	47476594	+	Silent	SNP	T	T	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr3:47476594T>A	uc003crh.1	-	3	411	c.156A>T	c.(154-156)ACA>ACT	p.T52T	SCAP_uc011baz.1_5'UTR|SCAP_uc003crg.2_5'UTR	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	52	Lumenal (By similarity).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		CCACAGGTCCTGTTCCTGGCA	0.537	Pancreas(149;978 1908 29304 37806 46700)		NA											19	63					0	0	0.010504	0	0
TMEM89	440955	broad.mit.edu	37	3	48659116	48659116	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr3:48659116C>A	uc011bbo.1	-	1	74	c.74G>T	c.(73-75)AGA>ATA	p.R25I		NM_001008269	NP_001008270	A2RUT3	TMM89_HUMAN	transmembrane protein 89 precursor	25	Extracellular (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;0.000286)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CCAGAGGGGTCTCGACCAGGC	0.662			NA											18	55					8.10497e-08	1.03716e-07	0.010504	1	0
FAM3D	131177	broad.mit.edu	37	3	58639474	58639474	+	Silent	SNP	T	T	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr3:58639474T>A	uc003dkq.2	-	3	345	c.48A>T	c.(46-48)ATA>ATT	p.I16I		NM_138805	NP_620160	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D	16					negative regulation of insulin secretion	extracellular region	cytokine activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)		ATGTCGTGACTATGGCAAAGA	0.567			NA											27	102					0	0	0.005443	0	0
ROBO2	6092	broad.mit.edu	37	3	77651370	77651370	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr3:77651370C>A	uc003dpy.3	+	20	3507	c.2864C>A	c.(2863-2865)CCA>CAA	p.P955Q	ROBO2_uc003dpz.2_Missense_Mutation_p.P959Q|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.P959Q|ROBO2_uc003dqa.2_Missense_Mutation_p.P82Q	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	955	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GATGTGCTGCCACCAGTTCCA	0.438			NA											14	80					6.94344e-10	9.36125e-10	0.006122	1	0
FBXO40	51725	broad.mit.edu	37	3	121341659	121341659	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr3:121341659C>A	uc003eeg.2	+	3	1593	c.1383C>A	c.(1381-1383)AGC>AGA	p.S461R		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	F-box protein 40	461					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(114;0.189)		AGCTCCACAGCGAGTGTGTGA	0.527			NA											9	33					3.09899e-07	3.83563e-07	0.004482	1	0
CCRL1	51554	broad.mit.edu	37	3	132320031	132320031	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr3:132320031G>T	uc003eow.2	+	2	873	c.790G>T	c.(790-792)GCC>TCC	p.A264S	ACAD11_uc003eov.3_Intron|ACAD11_uc011blr.1_Intron|CCRL1_uc003eox.2_Missense_Mutation_p.A264S	NM_016557	NP_057641	Q9NPB9	CCRL1_HUMAN	chemokine (C-C motif) receptor-like 1	264	Extracellular (Potential).				chemotaxis|immune response	integral to plasma membrane	C-C chemokine receptor activity				0						GTTCTGCCGAGCCATAGACAT	0.448	Pancreas(96;1505 1524 4501 17831 18121)		NA											20	155					1.13719e-10	1.57537e-10	0.008361	1	0
BCHE	590	broad.mit.edu	37	3	165548821	165548821	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr3:165548821T>G	uc003fem.3	-	2	161	c.1A>C	c.(1-3)ATG>CTG	p.M1L	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	1					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	TTGCTATGCATATTGATTTCT	0.308			NA											5	25					0	0	0.000602	0	0
ATP11B	23200	broad.mit.edu	37	3	182584182	182584182	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr3:182584182T>C	uc003flb.2	+	14	1827	c.1570T>C	c.(1570-1572)TAC>CAC	p.Y524H	ATP11B_uc003flc.2_Missense_Mutation_p.Y108H	NM_014616	NP_055431	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	524	Cytoplasmic (Potential).				aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			GCAGTTGGAGTACTATGCATC	0.433			NA											11	127					0	0	0.013537	0	0
WDFY3	23001	broad.mit.edu	37	4	85748131	85748131	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr4:85748131C>A	uc003hpd.2	-	10	1368	c.960G>T	c.(958-960)TTG>TTT	p.L320F	WDFY3_uc003hpf.2_Missense_Mutation_p.L320F	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	320						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TTGCTTGTTCCAATCTAGAAA	0.313			NA											17	86					4.96729e-08	6.46604e-08	0.008871	1	0
SH3D19	152503	broad.mit.edu	37	4	152048799	152048799	+	Missense_Mutation	SNP	C	C	A	rs146787893		TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr4:152048799C>A	uc010ipl.1	-	20	3317	c.2227G>T	c.(2227-2229)GGG>TGG	p.G743W	SH3D19_uc003imb.2_Missense_Mutation_p.G498W|SH3D19_uc003imc.2_Missense_Mutation_p.G684W|SH3D19_uc003ime.2_Missense_Mutation_p.G720W|SH3D19_uc010ipm.2_Missense_Mutation_p.G720W	NM_001009555	NP_001009555	Q5HYK7	SH319_HUMAN	SH3 domain containing 19 isoform a	743	SH3 5.				cellular membrane organization|positive regulation of membrane protein ectodomain proteolysis|post-Golgi vesicle-mediated transport	cytosol|Golgi apparatus|nucleus|plasma membrane	proline-rich region binding			ovary(1)|skin(1)	2	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				TCATTCTCCCCTCGGAAATCA	0.363			NA											7	41					1.08611e-07	1.37817e-07	0.010729	1	0
TRIML1	339976	broad.mit.edu	37	4	189068081	189068081	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr4:189068081C>T	uc003izm.1	+	6	1077	c.962C>T	c.(961-963)CCG>CTG	p.P321L	TRIML1_uc003izn.1_Missense_Mutation_p.P45L	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	321	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		CCCGACAACCCGGAAAGATTT	0.537	Melanoma(31;213 1036 16579 23968 32372)		NA											31	80					0	0	0.013726	0	0
CCDC127	133957	broad.mit.edu	37	5	205868	205868	+	Missense_Mutation	SNP	C	C	A	rs147467162		TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr5:205868C>A	uc003jam.1	-	3	427	c.327G>T	c.(325-327)CAG>CAT	p.Q109H		NM_145265	NP_660308	Q96BQ5	CC127_HUMAN	coiled-coil domain containing 127	109	Potential.										0			all cancers(22;0.0236)|Lung(60;0.113)			ACTTGCGTCCCTGAGAGATAA	0.478			NA											15	41					2.23348e-06	2.63481e-06	0.004007	1	0
WDR36	134430	broad.mit.edu	37	5	110441783	110441783	+	Missense_Mutation	SNP	G	G	A	rs145743089		TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr5:110441783G>A	uc003kpd.2	+	11	1406	c.1289G>A	c.(1288-1290)CGT>CAT	p.R430H	WDR36_uc010jbu.2_RNA	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36	430					response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		AGAGTTAAACGTAAAGGACTT	0.353			NA											6	110					0	0	0.001984	0	0
SNCAIP	9627	broad.mit.edu	37	5	121786347	121786347	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr5:121786347C>A	uc003ksw.1	+	10	2011	c.1805C>A	c.(1804-1806)TCA>TAA	p.S602*	SNCAIP_uc011cwl.1_Nonsense_Mutation_p.S160*|SNCAIP_uc003ksx.1_Nonsense_Mutation_p.S649*|SNCAIP_uc003ksy.1_Nonsense_Mutation_p.S236*|SNCAIP_uc003ksz.1_Nonsense_Mutation_p.S236*|SNCAIP_uc010jcu.2_Nonsense_Mutation_p.S198*|SNCAIP_uc011cwm.1_Nonsense_Mutation_p.S236*|SNCAIP_uc003kta.1_Nonsense_Mutation_p.S234*|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Nonsense_Mutation_p.S296*|SNCAIP_uc010jcx.1_Nonsense_Mutation_p.S542*|uc003ktb.1_RNA|SNCAIP_uc003ktc.1_Nonsense_Mutation_p.S118*	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	602					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		GGAAGCCTGTCAGCCTCCAGC	0.473			NA											21	61					3.51602e-12	5.10499e-12	0.008871	1	0
PCDHB7	56129	broad.mit.edu	37	5	140553136	140553136	+	Silent	SNP	T	T	C			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr5:140553136T>C	uc003lit.2	+	1	894	c.720T>C	c.(718-720)CCT>CCC	p.P240P		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	240	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACAACGCCCCTGATTTTGTGC	0.537			NA											3	75					0	0	0.004672	0	0
PCDHB12	56124	broad.mit.edu	37	5	140590121	140590121	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr5:140590121C>A	uc003liz.2	+	1	1831	c.1642C>A	c.(1642-1644)CGC>AGC	p.R548S	PCDHB12_uc011dak.1_Missense_Mutation_p.R211S	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	548	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCGCTGGTGCGCGTGCTGGT	0.706			NA											15	59					3.32936e-07	4.08726e-07	0.006122	1	0
PCDHB15	56121	broad.mit.edu	37	5	140625391	140625391	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr5:140625391G>A	uc003lje.2	+	1	245	c.245G>A	c.(244-246)GGG>GAG	p.G82E		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	82	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGCAGACCGGGCAGTTGATA	0.527			NA											11	70					0	0	0.001855	0	0
HIST1H2AA	221613	broad.mit.edu	37	6	25726547	25726547	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr6:25726547G>T	uc003nfc.2	-	1	244	c.209C>A	c.(208-210)GCG>GAG	p.A70E	HIST1H2BA_uc003nfd.2_5'Flank	NM_170745	NP_734466	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa	70					nucleosome assembly	nucleosome|nucleus	DNA binding				0						ATCGCGAGACGCATTGCCTGC	0.517			NA											14	74					9.31168e-06	1.08159e-05	0.001855	1	0
CUL9	23113	broad.mit.edu	37	6	43154806	43154806	+	Missense_Mutation	SNP	G	G	T	rs145250491	by1000genomes	TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr6:43154806G>T	uc003ouk.2	+	5	1435	c.1360G>T	c.(1360-1362)GGG>TGG	p.G454W	CUL9_uc003ouj.1_Intron|CUL9_uc003oul.2_Missense_Mutation_p.G454W|CUL9_uc010jyk.2_5'UTR|CUL9_uc003oum.1_5'UTR	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	454					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						TGTGGAGAAGGGGGCAGGGGC	0.572			NA											12	26					3.07112e-06	3.59487e-06	0.010729	1	0
IMPG1	3617	broad.mit.edu	37	6	76713658	76713658	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr6:76713658C>T	uc003pik.1	-	11	1275	c.1145G>A	c.(1144-1146)GGA>GAA	p.G382E		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	382					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TGGCAGTGATCCAGCAATTTC	0.393	Pancreas(37;839 1141 2599 26037)		NA											13	47					0	0	0.00499	0	0
ENPP1	5167	broad.mit.edu	37	6	132211538	132211538	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr6:132211538A>G	uc011ecf.1	+	25	2685	c.2665A>G	c.(2665-2667)ATC>GTC	p.I889V		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	889	Nuclease.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	CAGAGCACGGATCACAGATGT	0.383	Colon(104;336 1535 5856 11019 33782)		NA											12	105					0	0	0.003163	0	0
TIAM2	26230	broad.mit.edu	37	6	155458593	155458593	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr6:155458593C>A	uc003qqb.2	+	7	2750	c.1477C>A	c.(1477-1479)CTG>ATG	p.L493M	TIAM2_uc003qqe.2_Missense_Mutation_p.L493M|TIAM2_uc010kjj.2_Missense_Mutation_p.L26M	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	493					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		ACTCAGCTCTCTGGAACAGCT	0.527			NA											26	123					2.61193e-14	3.90497e-14	0.009535	1	0
NOX3	50508	broad.mit.edu	37	6	155776234	155776235	+	Missense_Mutation	DNP	CA	CA	AG			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr6:155776234_155776235CA>AG	uc003qqm.2	-	2	180_181	c.77_78TG>CT	c.(76-78)CTG>CCT	p.L26P		NM_015718	NP_056533	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	26	Helical; (Potential).						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		TGTCAATAAACAGATAAAAATT	0.347			NA											12	42					0	0	0.004672	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31123774	31123774	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr7:31123774G>T	uc003tca.1	+	7	570	c.347G>T	c.(346-348)CGG>CTG	p.R116L	ADCYAP1R1_uc003tcb.1_Missense_Mutation_p.R95L|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.R116L|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.R116L|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.R116L|ADCYAP1R1_uc003tcf.1_5'Flank	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	116	Extracellular (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						GTGGTGAGCCGGAACTGCACG	0.483	Ovarian(44;225 1186 2158 11092)		NA											11	68					6.72482e-11	9.4023e-11	0.003163	1	0
ZNF479	90827	broad.mit.edu	37	7	57187809	57187809	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr7:57187809T>G	uc010kzo.2	-	5	1584	c.1313A>C	c.(1312-1314)AAA>ACA	p.K438T		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	438	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TTCTTCACATTTGTAGGGTCT	0.453			NA											5	103					0	0	0.006214	0	0
BHLHA15	168620	broad.mit.edu	37	7	97841993	97841993	+	Silent	SNP	C	C	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr7:97841993C>T	uc003upe.1	+	2	459	c.372C>T	c.(370-372)ATC>ATT	p.I124I	BHLHA15_uc003upf.1_Silent_p.I124I	NM_177455	NP_803238	Q7RTS1	BHA15_HUMAN	basic helix-loop-helix family, member a15	124	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						AGAACTACATCAAATCGCTGA	0.622			NA											3	2					0	0	0.004672	0	0
ADAM18	8749	broad.mit.edu	37	8	39467017	39467017	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr8:39467017A>T	uc003xni.2	+	5	281	c.281A>T	c.(280-282)TAC>TTC	p.Y94F	ADAM18_uc003xnh.2_Missense_Mutation_p.Y94F|ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Missense_Mutation_p.Y94F	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	94					cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			CATTGCCATTACCAAGGATAT	0.323			NA											16	62					0	0	0.008871	0	0
TM7SF4	81501	broad.mit.edu	37	8	105361635	105361635	+	Silent	SNP	G	G	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr8:105361635G>A	uc003ylx.1	+	2	904	c.855G>A	c.(853-855)CCG>CCA	p.P285P		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	285					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTTTCTGGCCGACTCCTAAAG	0.478			NA											4	87					0	0	0.009096	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110498976	110498976	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr8:110498976C>A	uc003yne.2	+	59	9910	c.9806C>A	c.(9805-9807)CCC>CAC	p.P3269H		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3269	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GAAGATTACCCCGGTTGGTCT	0.423			NA								HNSCC(38;0.096)			41	244					1.6237e-14	2.45178e-14	0.013114	1	0
PLEC	5339	broad.mit.edu	37	8	144991090	144991090	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr8:144991090C>T	uc003zaf.1	-	32	13480	c.13310G>A	c.(13309-13311)CGG>CAG	p.R4437Q	PLEC_uc003zab.1_Missense_Mutation_p.R4300Q|PLEC_uc003zac.1_Missense_Mutation_p.R4304Q|PLEC_uc003zad.2_Missense_Mutation_p.R4300Q|PLEC_uc003zae.1_Missense_Mutation_p.R4268Q|PLEC_uc003zag.1_Missense_Mutation_p.R4278Q|PLEC_uc003zah.2_Missense_Mutation_p.R4286Q|PLEC_uc003zaj.2_Missense_Mutation_p.R4327Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4437	Globular 2.|Plectin 29.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CACCAGGTTCCGGTGCATGGC	0.677			NA											5	57					0	0	0.000602	0	0
TTC39B	158219	broad.mit.edu	37	9	15185366	15185366	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr9:15185366G>A	uc003zlr.1	-	16	1449	c.1328C>T	c.(1327-1329)TCT>TTT	p.S443F	TTC39B_uc003zlq.1_Missense_Mutation_p.S412F|TTC39B_uc011lmp.1_Missense_Mutation_p.S344F|TTC39B_uc010mie.1_Missense_Mutation_p.S441F|TTC39B_uc011lmq.1_Missense_Mutation_p.S430F|TTC39B_uc011lmr.1_Missense_Mutation_p.S374F|TTC39B_uc003zlp.1_Missense_Mutation_p.S26F	NM_152574	NP_689787	Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B	443							binding			ovary(1)	1						AGTAGGGATAGATTTCCCGGC	0.512			NA											25	130					0	0	0.010818	0	0
PPEF1	5475	broad.mit.edu	37	X	18775846	18775846	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chrX:18775846G>T	uc004cyq.2	+	8	979	c.498G>T	c.(496-498)GAG>GAT	p.E166D	PPEF1_uc004cyp.2_Missense_Mutation_p.E166D|PPEF1_uc004cyr.2_Missense_Mutation_p.E166D|PPEF1_uc004cys.2_Missense_Mutation_p.E166D|PPEF1_uc011mja.1_Missense_Mutation_p.E101D|PPEF1_uc011mjb.1_Missense_Mutation_p.E110D	NM_006240	NP_006231	O14829	PPE1_HUMAN	protein phosphatase with EF hand calcium-binding	166	Catalytic.				detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity				0	Hepatocellular(33;0.183)					CCTCCAAAGAGGTAACAATCT	0.393			NA											32	128					1.61788e-16	2.51855e-16	0.012213	1	0
PFKFB1	5207	broad.mit.edu	37	X	54989698	54989698	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chrX:54989698G>T	uc004dty.1	-	2	286	c.215C>A	c.(214-216)CCA>CAA	p.P72Q	PFKFB1_uc010nkd.1_Missense_Mutation_p.P80Q|PFKFB1_uc011mol.1_Intron	NM_002625	NP_002616	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,	72	6-phosphofructo-2-kinase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(1)	1						ACCTTTAGTTGGTGTTCCTAT	0.448			NA											57	238					1.37693e-34	2.31019e-34	0.01441	1	0
NHSL2	340527	broad.mit.edu	37	X	71360515	71360515	+	Silent	SNP	G	G	A	rs147793067		TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chrX:71360515G>A	uc011mqa.1	+	6	3117	c.3117G>A	c.(3115-3117)CTG>CTA	p.L1039L	NHSL2_uc004eak.1_Silent_p.L673L|NHSL2_uc010nli.2_Silent_p.L808L	NM_001013627	NP_001013649	Q5HYW2	NHSL2_HUMAN	NHS-like 2	1039											0	Renal(35;0.156)					TCATCACCCTGGAGGAAGACA	0.567			NA											7	50					0	0	0.001984	0	0
SATL1	340562	broad.mit.edu	37	X	84362763	84362763	+	Silent	SNP	T	T	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chrX:84362763T>A	uc011mqx.1	-	1	1212	c.1212A>T	c.(1210-1212)TCA>TCT	p.S404S	SATL1_uc004een.2_Silent_p.S404S	NM_001163541	NP_001157013	Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	217	Gln-rich.						N-acetyltransferase activity			breast(2)	2						GGCTTGTGCCTGATTGGCTGG	0.537			NA											39	95					0	0	0.007835	0	0
GPR50	9248	broad.mit.edu	37	X	150349245	150349245	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chrX:150349245G>A	uc010ntg.1	+	2	1325	c.1190G>A	c.(1189-1191)CGC>CAC	p.R397H	uc004fes.1_5'Flank	NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	397	Cytoplasmic (Potential).|Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCTGCCTATCGCAAATCTGCC	0.582			NA											48	166					0	0	0.01441	0	0
PLXNA3	55558	broad.mit.edu	37	X	153696202	153696202	+	Silent	SNP	G	G	T			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chrX:153696202G>T	uc004flm.2	+	21	3851	c.3678G>T	c.(3676-3678)GCG>GCT	p.A1226A		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1226	Helical; (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGCTGGCGGCGGGGGGTGGGC	0.687			NA											14	52					1.99824e-07	2.49367e-07	0.00499	1	0
OR2M2	391194	broad.mit.edu	37	1	248343596	248343597	+	Frame_Shift_Ins	INS	-	-	TA			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr1:248343596_248343597insTA	uc010pzf.1	+	1	309_310	c.309_310insTA	c.(307-312)TTCTATfs	p.F103fs		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	103_104	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AAATTTTCTTCTATATATCACT	0.431			NA											11	434	---	---	---	---	NA	NA	NA	NA	NA
FAR2	55711	broad.mit.edu	37	12	29450110	29450110	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr12:29450110delA	uc001ris.3	+	4	669	c.522delA	c.(520-522)CCAfs	p.P174fs	FAR2_uc001rit.2_Frame_Shift_Del_p.P174fs|FAR2_uc009zjm.2_Frame_Shift_Del_p.P77fs|uc001riu.1_Intron	NM_018099	NP_060569	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	174					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor				0						CTGTGGAGCCAAAAAAAATCA	0.388			NA											7	294	---	---	---	---	NA	NA	NA	NA	NA
FDXR	2232	broad.mit.edu	37	17	72862664	72862665	+	Frame_Shift_Del	DEL	CG	CG	-	rs141174234		TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr17:72862664_72862665delCG	uc002jly.2	-	4	383_384	c.296_297delCG	c.(295-297)ACGfs	p.T99fs	FDXR_uc010wri.1_Frame_Shift_Del_p.T47fs|FDXR_uc010wrj.1_Frame_Shift_Del_p.T97fs|FDXR_uc002jlw.2_5'UTR|FDXR_uc002jlx.2_Frame_Shift_Del_p.T99fs|FDXR_uc002jmc.2_Frame_Shift_Del_p.T100fs|FDXR_uc010wrk.1_Frame_Shift_Del_p.T130fs|FDXR_uc010wrl.1_Frame_Shift_Del_p.T142fs|FDXR_uc002jma.2_Frame_Shift_Del_p.T100fs|FDXR_uc010wrm.1_Intron|FDXR_uc002jlz.2_Frame_Shift_Del_p.T91fs|FDXR_uc002jmb.2_RNA	NM_024417	NP_077728	P22570	ADRO_HUMAN	ferredoxin reductase isoform 1 precursor	99					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding				0	all_lung(278;0.172)|Lung NSC(278;0.207)					CAGAATGGGCCGTCTGGGTAAA	0.639			NA											7	71	---	---	---	---	NA	NA	NA	NA	NA
TMEM90B	79953	broad.mit.edu	37	20	24524183	24524185	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	GGA	GGA	-	-	GGA	GGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr20:24524183_24524185delGGA	uc002wtw.1	+	2	1083_1085	c.450_452delGGA	c.(448-453)GTGGAG>GTG	p.E155del		NM_024893	NP_079169	Q9H7V2	SYNG1_HUMAN	transmembrane protein 90B	155	Poly-Glu.|Cytoplasmic (Potential).				response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane					0						CCTACGATGTGGAGGAGGAGGAG	0.547			NA											7	310	---	---	---	---	NA	NA	NA	NA	NA
EGF	1950	broad.mit.edu	37	4	110883117	110883120	+	Frame_Shift_Del	DEL	GAGA	GAGA	-			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	GAGA	GAGA	-	-	GAGA	GAGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr4:110883117_110883120delGAGA	uc003hzy.3	+	8	1740_1743	c.1288_1291delGAGA	c.(1288-1293)GAGAGAfs	p.E430fs	EGF_uc011cfu.1_Frame_Shift_Del_p.E388fs|EGF_uc011cfv.1_Frame_Shift_Del_p.E430fs	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	430_431	EGF-like 3.|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	CTCAGTGCTTGAGAGAGATGGGAA	0.397			NA											9	232	---	---	---	---	NA	NA	NA	NA	NA
BHLHA15	168620	broad.mit.edu	37	7	97842081	97842083	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-55-7728-01A-11D-2184-08	TCGA-55-7728-10A-01D-2184-08	CAG	CAG	-	-	CAG	CAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	be345756-62d1-4c2f-a2f2-fceb95f13364	d97318e0-a7ec-44e9-a46d-ef62081afc05	g.chr7:97842081_97842083delCAG	uc003upe.1	+	2	547_549	c.460_462delCAG	c.(460-462)CAGdel	p.Q158del	BHLHA15_uc003upf.1_In_Frame_Del_p.Q158del	NM_177455	NP_803238	Q7RTS1	BHA15_HUMAN	basic helix-loop-helix family, member a15	158					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						CCAGCACTACCAGCAGCAGCAGC	0.665			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
