Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CAMTA1	23261	broad.mit.edu	37	1	7792638	7792638	+	Silent	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:7792638G>T	uc001aoi.2	+	12	3252	c.3045G>T	c.(3043-3045)GGG>GGT	p.G1015G	CAMTA1_uc010nzv.1_Silent_p.G102G|CAMTA1_uc001aok.3_Silent_p.G58G	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1015					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GCGGGAGCGGGAATGGAGGGA	0.632			NA											3	10					1.23904e-05	1.5366e-05	0.000602	1	0
UTS2	10911	broad.mit.edu	37	1	7913047	7913047	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:7913047G>A	uc001aor.2	-	1	58	c.17C>T	c.(16-18)TCC>TTC	p.S6F	UTS2_uc001aoq.2_Missense_Mutation_p.S6F|UTS2_uc001aos.2_Intron	NM_006786	NP_006777	O95399	UTS2_HUMAN	urotensin 2 isoform b preproprotein	6					muscle contraction|regulation of blood pressure|synaptic transmission	extracellular space	hormone activity				0	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;1.38e-20)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.26e-71)|GBM - Glioblastoma multiforme(8;5.15e-36)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000386)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|STAD - Stomach adenocarcinoma(132;0.000951)|READ - Rectum adenocarcinoma(331;0.0642)		CAAACAGCAGGAGGCCAGCTT	0.423			NA											6	35					0	0	0.001168	0	0
UBE4B	10277	broad.mit.edu	37	1	10238772	10238772	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:10238772T>C	uc001aqs.3	+	26	4309	c.3596T>C	c.(3595-3597)ATA>ACA	p.I1199T	UBE4B_uc001aqr.3_Missense_Mutation_p.I1070T|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Missense_Mutation_p.I654T|UBE4B_uc001aqu.2_Missense_Mutation_p.I80T	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	1199					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		AAATCCACAATAGCAATAGAA	0.458			NA											8	22					0	0	0.004482	0	0
PADI3	51702	broad.mit.edu	37	1	17593303	17593303	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:17593303T>G	uc001bai.2	+	5	538	c.498T>G	c.(496-498)AAT>AAG	p.N166K		NM_016233	NP_057317	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	166					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(1)|breast(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	TCCAGGACAATTGTGACCAGC	0.617			NA											22	90					0	0	0.005443	0	0
KIF17	57576	broad.mit.edu	37	1	20992805	20992805	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:20992805A>T	uc001bdr.3	-	14	2931	c.2813T>A	c.(2812-2814)CTC>CAC	p.L938H	KIF17_uc001bdp.3_Missense_Mutation_p.L215H|KIF17_uc001bdq.3_Missense_Mutation_p.L216H|KIF17_uc009vpx.2_Missense_Mutation_p.L308H|KIF17_uc001bds.3_Missense_Mutation_p.L937H	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	938					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		ACTGAGCATGAGCCTGTAGCG	0.597			NA											33	101					0	0	0.002522	0	0
C1orf109	54955	broad.mit.edu	37	1	38155304	38155304	+	Silent	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:38155304G>T	uc001cbp.2	-	2	439	c.249C>A	c.(247-249)ATC>ATA	p.I83I	C1orf109_uc010oig.1_Silent_p.I146I|C1orf109_uc001cbo.2_Silent_p.I145I|C1orf109_uc001cbq.1_Intron|CDCA8_uc001cbr.2_5'Flank|CDCA8_uc001cbs.2_5'Flank	NM_017850	NP_060320	Q9NX04	CA109_HUMAN	hypothetical protein LOC54955	83											0		Myeloproliferative disorder(586;0.0393)				TGTCCAGGACGATGTCACCAG	0.532			NA											4	79					0.00116845	0.00132874	0.001168	1	0
ELTD1	64123	broad.mit.edu	37	1	79387384	79387384	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:79387384G>T	uc001diq.3	-	9	1327	c.1171C>A	c.(1171-1173)CTG>ATG	p.L391M		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	391	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		GAGTATGTCAGCTCACAGCCC	0.423			NA											17	61					6.49762e-13	9.79306e-13	0.006122	1	0
OLFM3	118427	broad.mit.edu	37	1	102270424	102270424	+	Silent	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:102270424G>A	uc001duf.2	-	6	878	c.807C>T	c.(805-807)TAC>TAT	p.Y269Y	OLFM3_uc001dug.2_Silent_p.Y249Y|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Silent_p.Y174Y|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	269	Olfactomedin-like.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		CAATTGATTTGTATTCACGAA	0.378			NA											3	53					0	0	0.004672	0	0
CEPT1	10390	broad.mit.edu	37	1	111724837	111724837	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:111724837T>C	uc001eah.1	+	6	951	c.743T>C	c.(742-744)ATT>ACT	p.I248T	CEPT1_uc001eai.1_Missense_Mutation_p.I248T|CEPT1_uc001eaj.1_Missense_Mutation_p.I248T|CEPT1_uc009wfz.1_Intron	NM_001007794	NP_001007795	Q9Y6K0	CEPT1_HUMAN	choline/ethanolaminephosphotransferase	248	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	diacylglycerol cholinephosphotransferase activity|ethanolaminephosphotransferase activity|metal ion binding				0		all_cancers(81;2.27e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0173)|Colorectal(144;0.0375)|all cancers(265;0.0701)|LUSC - Lung squamous cell carcinoma(189;0.0888)|Epithelial(280;0.103)|COAD - Colon adenocarcinoma(174;0.141)	Choline(DB00122)	CAAATGAAAATTTTTCCTGCA	0.318			NA											2	29					0	0	0.004672	0	0
FLG2	388698	broad.mit.edu	37	1	152328222	152328222	+	Silent	SNP	A	A	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:152328222A>G	uc001ezw.3	-	3	2113	c.2040T>C	c.(2038-2040)GGT>GGC	p.G680G	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	680	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTTGTCCAAAACCAGAGGATT	0.478			NA											4	354					0	0	0.001368	0	0
NES	10763	broad.mit.edu	37	1	156646857	156646857	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:156646857A>T	uc001fpq.2	-	1	333	c.200T>A	c.(199-201)GTT>GAT	p.V67D		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	67	Coil 1B.|Rod.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCGTTGGTCAACGAGGGCCCG	0.736			NA											4	4					0	0	0.000602	0	0
INSRR	3645	broad.mit.edu	37	1	156814505	156814505	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:156814505C>A	uc010pht.1	-	13	2822	c.2568G>T	c.(2566-2568)TTG>TTT	p.L856F	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	856	Fibronectin type-III 3.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTACCTCTCCCAAGCGGCGGT	0.617			NA											34	45					1.59361e-14	2.48508e-14	0.006999	1	0
CD1E	913	broad.mit.edu	37	1	158324263	158324263	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:158324263A>T	uc001fse.2	+	2	394	c.155A>T	c.(154-156)CAC>CTC	p.H52L	CD1E_uc010pid.1_Missense_Mutation_p.H50L|CD1E_uc010pie.1_Intron|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Missense_Mutation_p.H52L|CD1E_uc001fsk.2_Missense_Mutation_p.H52L|CD1E_uc001fsj.2_Missense_Mutation_p.H52L|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.H52L|CD1E_uc001fry.2_Missense_Mutation_p.H52L|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Missense_Mutation_p.H52L|CD1E_uc009wsv.2_Intron|CD1E_uc001frz.2_Missense_Mutation_p.H52L|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	52					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					AGCTGGGCACACAGTGAGGGC	0.572			NA											30	49					0	0	0.007291	0	0
OR10K2	391107	broad.mit.edu	37	1	158390131	158390131	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:158390131G>C	uc010pii.1	-	1	526	c.526C>G	c.(526-528)CAC>GAC	p.H176D		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					CAGAAGAAGTGATGTAGTTGA	0.468			NA											10	113					0	0	0.001368	0	0
OR6N2	81442	broad.mit.edu	37	1	158747012	158747012	+	Silent	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:158747012G>A	uc010pir.1	-	1	414	c.414C>T	c.(412-414)ACC>ACT	p.T138T		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	138	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					CACAGAGTGTGGTGGTCATAA	0.512			NA											21	44					0	0	0.00333	0	0
RGS8	85397	broad.mit.edu	37	1	182636035	182636035	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:182636035G>C	uc010pnw.1	-	4	358	c.100C>G	c.(100-102)CTT>GTT	p.L34V	RGS8_uc001gpn.1_Missense_Mutation_p.L34V|RGS8_uc001gpm.1_Missense_Mutation_p.L52V	NM_001102450	NP_001095920	P57771	RGS8_HUMAN	regulator of G-protein signalling 8 isoform 2	34					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)	1						TTGTCTGGAAGAATAGCTGTG	0.502	Ovarian(189;1262 3804 41973)		NA											6	105					0	0	0.00308	0	0
NMNAT2	23057	broad.mit.edu	37	1	183221856	183221856	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:183221856C>T	uc001gqc.1	-	11	1179	c.844G>A	c.(844-846)GGC>AGC	p.G282S	NMNAT2_uc009wye.1_RNA|NMNAT2_uc001gqb.1_Missense_Mutation_p.G277S	NM_015039	NP_055854	Q9BZQ4	NMNA2_HUMAN	nicotinamide mononucleotide adenylyltransferase	282					water-soluble vitamin metabolic process	Golgi membrane|nucleus	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity			skin(1)	1						ACAACATGGCCGTCCCCATGC	0.582			NA											32	53					0	0	0.003271	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202418211	202418211	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:202418211C>T	uc001gya.1	+	13	1906	c.1762C>T	c.(1762-1764)CTT>TTT	p.L588F	PPP1R12B_uc001gxz.1_Missense_Mutation_p.L588F	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	588					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			CAATCGCCCTCTTCCTAGCAC	0.512			NA											6	56					0	0	0.001168	0	0
KLHDC8A	55220	broad.mit.edu	37	1	205312401	205312401	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:205312401C>T	uc001hcf.1	-	2	900	c.332G>A	c.(331-333)AGC>AAC	p.S111N	KLHDC8A_uc010prg.1_Intron|KLHDC8A_uc001hcg.1_Missense_Mutation_p.S111N	NM_018203	NP_060673	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	111	Kelch 3.									ovary(1)	1	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			ACGCAGCATGCTCCTCTTCTT	0.622			NA											13	190					0	0	0.003163	0	0
IRF6	3664	broad.mit.edu	37	1	209965758	209965758	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:209965758G>C	uc001hhq.1	-	6	786	c.523C>G	c.(523-525)CCA>GCA	p.P175A	IRF6_uc010psm.1_Missense_Mutation_p.P80A|IRF6_uc009xct.1_Missense_Mutation_p.P175A	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	175					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		ACACTGGCTGGCGCCATGGGA	0.547			NA								HNSCC(57;0.16)			3	40					0	0	0.000602	0	0
USH2A	7399	broad.mit.edu	37	1	215972392	215972392	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:215972392G>T	uc001hku.1	-	50	10202	c.9815C>A	c.(9814-9816)CCG>CAG	p.P3272Q		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3272	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGTGGAGTACGGCATTCTGCC	0.483			NA								HNSCC(13;0.011)			18	31					1.67942e-08	2.30007e-08	0.006122	1	0
MIA3	375056	broad.mit.edu	37	1	222828121	222828121	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:222828121G>T	uc001hnl.2	+	18	4602	c.4593G>T	c.(4591-4593)GAG>GAT	p.E1531D	MIA3_uc001hnm.2_Missense_Mutation_p.E409D	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1531	Cytoplasmic (Potential).|Potential.				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		AGCAGAAGGAGATGGCTTTGC	0.373			NA											22	38					4.26978e-12	6.31446e-12	0.00333	1	0
TRIM67	440730	broad.mit.edu	37	1	231298752	231298752	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:231298752C>G	uc009xfn.1	+	1	79	c.37C>G	c.(37-39)CTG>GTG	p.L13V		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	tripartite motif-containing 67	13	RING-type; degenerate.					cytoplasm|cytoskeleton	zinc ion binding			ovary(2)|breast(1)|kidney(1)	4	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				GTGCGGCTCTCTGTTTCGGGA	0.667			NA											3	23					0	0	0.000602	0	0
OR2T2	401992	broad.mit.edu	37	1	248616171	248616171	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:248616171C>A	uc001iek.1	+	1	73	c.73C>A	c.(73-75)CCC>ACC	p.P25T		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	25	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCCTGCCTTCCCCGGGCTTCT	0.532			NA											4	149					2.17888e-05	2.68104e-05	0.006214	1	0
OR2T3	343173	broad.mit.edu	37	1	248637204	248637204	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr1:248637204G>T	uc001iel.1	+	1	553	c.553G>T	c.(553-555)GAG>TAG	p.E185*		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	185	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTTTTTCTGTGAGACTCCTGC	0.517			NA											7	45					3.09899e-07	4.06742e-07	0.004482	1	0
GAD2	2572	broad.mit.edu	37	10	26589834	26589834	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr10:26589834C>A	uc001isp.2	+	16	2205	c.1702C>A	c.(1702-1704)CAC>AAC	p.H568N	GAD2_uc001isq.2_Missense_Mutation_p.H568N	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	568					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	AGCGGCAACTCACCAAGACAT	0.448			NA											21	76					1.55469e-16	2.49862e-16	0.00333	1	0
ANKRD30A	91074	broad.mit.edu	37	10	37430773	37430773	+	Silent	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr10:37430773G>A	uc001iza.1	+	7	879	c.780G>A	c.(778-780)ACG>ACA	p.T260T		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	316						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CACCTGACACGGCTGAAAGCT	0.493			NA											3	37					0	0	0.004672	0	0
SGMS1	259230	broad.mit.edu	37	10	52103589	52103589	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr10:52103589C>A	uc001jje.2	-	7	1240	c.286G>T	c.(286-288)GGC>TGC	p.G96C	SGMS1_uc010qhk.1_Intron|SGMS1_uc009xot.1_Intron|SGMS1_uc009xou.1_Missense_Mutation_p.G96C|SGMS1_uc010qhl.1_RNA	NM_147156	NP_671512	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	102					apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			ovary(1)|kidney(1)	2						CTGAAGCTGCCGTCGGGGGTG	0.512			NA											8	56					0.00448238	0.00500691	0.004482	1	0
HK1	3098	broad.mit.edu	37	10	71158462	71158462	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr10:71158462G>C	uc001jpl.3	+	17	2588	c.2487G>C	c.(2485-2487)AGG>AGC	p.R829S	HK1_uc001jpg.3_Missense_Mutation_p.R817S|HK1_uc001jph.3_Missense_Mutation_p.R833S|HK1_uc001jpi.3_Missense_Mutation_p.R833S|HK1_uc001jpj.3_Missense_Mutation_p.R864S|HK1_uc001jpk.3_Missense_Mutation_p.R828S	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	829	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						TGTCCAGGAGGGCCGCACAGC	0.602			NA											8	45					0	0	0.000978	0	0
TRIM8	81603	broad.mit.edu	37	10	104416839	104416839	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr10:104416839G>T	uc001kvz.2	+	6	1507	c.1384G>T	c.(1384-1386)GGC>TGC	p.G462C		NM_030912	NP_112174	Q9BZR9	TRIM8_HUMAN	tripartite motif-containing 8	462						cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CCAGTATGGCGGCCGCAAGAT	0.657			NA											9	53					0.000673444	0.000768605	0.008291	1	0
PDCD11	22984	broad.mit.edu	37	10	105205183	105205183	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr10:105205183G>T	uc001kwy.1	+	36	5580	c.5493G>T	c.(5491-5493)ATG>ATT	p.M1831I		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1831	HAT 4.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		CCAAGAGAATGAAGTTCTTCT	0.542			NA											15	78					2.35188e-11	3.44578e-11	0.006122	1	0
SORCS3	22986	broad.mit.edu	37	10	106401672	106401672	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr10:106401672A>C	uc001kyi.1	+	1	814	c.587A>C	c.(586-588)CAC>CCC	p.H196P		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	196	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GACTCGGCCCACAACCAAGCC	0.706	NSCLC(116;1497 1690 7108 13108 14106)		NA											3	20					0	0	0.000602	0	0
TUBGCP2	10844	broad.mit.edu	37	10	135097385	135097385	+	Splice_Site	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr10:135097385C>T	uc001lmg.1	-	14	2502	c.2145_splice	c.e14+1	p.S715_splice	TUBGCP2_uc001lmf.1_Splice_Site_p.S308_splice|TUBGCP2_uc010qvc.1_Splice_Site_p.S743_splice|TUBGCP2_uc009ybk.1_Splice_Site_p.S738_splice|TUBGCP2_uc010qvd.1_Splice_Site_p.S585_splice|TUBGCP2_uc001lmh.1_Splice_Site	NM_006659	NP_006650	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2						G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		CTAAAACTCACGGATTTCAGG	0.378			NA											3	73					0	0	0.000602	0	0
EPS8L2	64787	broad.mit.edu	37	11	721571	721571	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:721571C>G	uc001lqt.2	+	10	1022	c.775C>G	c.(775-777)CTC>GTC	p.L259V	EPS8L2_uc010qwj.1_Missense_Mutation_p.L275V|EPS8L2_uc001lqu.2_Missense_Mutation_p.L259V|EPS8L2_uc010qwk.1_Missense_Mutation_p.L275V|EPS8L2_uc001lqv.2_Missense_Mutation_p.L214V|EPS8L2_uc001lqw.2_5'UTR|EPS8L2_uc001lqx.2_5'Flank|EPS8L2_uc001lqy.2_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	259						cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCAGCAAATCCTCAACTGCGC	0.632			NA											3	15					0	0	0.004672	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1643028	1643028	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:1643028C>A	uc009ycy.1	-	3	521	c.434G>T	c.(433-435)GGG>GTG	p.G145V		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	159	9 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GCCACAGCCCCCCTTGGAACC	0.682			NA											10	79					2.48551e-13	3.81919e-13	0.00499	1	0
CALCA	796	broad.mit.edu	37	11	14992652	14992652	+	Splice_Site	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:14992652C>G	uc001mlt.1	-	2	161	c.86_splice	c.e2+1	p.R29_splice	CALCA_uc001mlu.1_Splice_Site|CALCA_uc001mlv.1_Splice_Site_p.R29_splice|CALCA_uc001mlw.1_Splice_Site_p.R29_splice	NM_001033953	NP_001029125	P06881	CALCA_HUMAN	calcitonin isoform CGRP preproprotein						activation of adenylate cyclase activity|cell-cell signaling|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|endothelial cell migration|endothelial cell proliferation|leukocyte cell-cell adhesion|negative regulation of blood pressure|negative regulation of bone resorption|negative regulation of calcium ion transport into cytosol|negative regulation of osteoclast differentiation|neurological system process involved in regulation of systemic arterial blood pressure|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-8 production|positive regulation of macrophage differentiation|positive regulation of vasodilation|regulation of blood pressure|vasculature development|vasodilation	cytosol|extracellular space	hormone activity			central_nervous_system(1)	1					Phentolamine(DB00692)	GGCTGTCTTACCTGAATGGTG	0.418			NA											7	58					0	0	0.00308	0	0
SLC17A6	57084	broad.mit.edu	37	11	22399021	22399021	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:22399021C>A	uc001mqk.2	+	12	1897	c.1484C>A	c.(1483-1485)GCA>GAA	p.A495E		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	495	Helical; (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						ATATTTTATGCAATATTTGCC	0.438			NA											7	39					5.18039e-06	6.55351e-06	0.00308	1	0
C11orf41	25758	broad.mit.edu	37	11	33566850	33566850	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:33566850C>T	uc001mup.3	+	2	2562	c.2438C>T	c.(2437-2439)GCT>GTT	p.A813V	C11orf41_uc001mun.1_Missense_Mutation_p.A813V	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	807						integral to membrane				ovary(2)	2						GCTGCATCGGCTGCAGTGGTC	0.547			NA											3	27					0	0	0.004672	0	0
CREB3L1	90993	broad.mit.edu	37	11	46342033	46342033	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:46342033G>A	uc001ncf.2	+	11	1912	c.1477G>A	c.(1477-1479)GGC>AGC	p.G493S	CREB3L1_uc001ncg.2_Missense_Mutation_p.G127S	NM_052854	NP_443086	Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like	493	Lumenal (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	soft_tissue(6)|ovary(2)	8				GBM - Glioblastoma multiforme(35;0.0285)		CGGTGGAAACGGCACCAGCCC	0.637	Pancreas(3;159 194 19597 26278 47995)		NA	T	FUS	myxofibrosarcoma								3	11					0	0	0.000248	0	0
OR4C6	219432	broad.mit.edu	37	11	55433333	55433333	+	Missense_Mutation	SNP	C	C	T	rs140747151	byFrequency	TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:55433333C>T	uc001nht.3	+	3	956	c.691C>T	c.(691-693)CGG>TGG	p.R231W	OR4C6_uc010rik.1_Missense_Mutation_p.R231W	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						CTCTAAAGGGCGGCACAAAGC	0.502			NA											3	94					0	0	0.000248	0	0
OR5L1	219437	broad.mit.edu	37	11	55579671	55579672	+	Missense_Mutation	DNP	CC	CC	TA			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:55579671_55579672CC>TA	uc001nhw.1	+	1	729_730	c.729_730CC>TA	c.(727-732)TCCCAC>TCTAAC	p.H244N		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	244	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				CCTGTGCTTCCCACCTCACAGC	0.52			NA											11	75					0	0	0.004672	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798471	55798471	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:55798471C>A	uc010riw.1	+	1	577	c.577C>A	c.(577-579)CAG>AAG	p.Q193K		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	193	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					TACAGACACTCAGATCAACCA	0.418			NA											28	206					3.76114e-14	5.83625e-14	0.004289	1	0
OR5AS1	219447	broad.mit.edu	37	11	55798836	55798836	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:55798836G>T	uc010riw.1	+	1	942	c.942G>T	c.(940-942)TGG>TGT	p.W314C		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	314	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					CAAATGAATGGTATTTAAATC	0.269			NA											5	26					0.000157383	0.000184984	0.00308	1	0
OR5T2	219464	broad.mit.edu	37	11	55999767	55999767	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:55999767C>A	uc010rjc.1	-	1	895	c.895G>T	c.(895-897)GTG>TTG	p.V299L		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	299	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					CTTGGTCTCACATACATGAAG	0.428			NA											22	116					1.22574e-08	1.70091e-08	0.002299	1	0
OR5M1	390168	broad.mit.edu	37	11	56380698	56380698	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:56380698T>A	uc001nja.1	-	1	281	c.281A>T	c.(280-282)TAC>TTC	p.Y94F		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						GCATCCAGCGTAGGAGATGGT	0.448			NA											12	56					0	0	0.00499	0	0
CLP1	10978	broad.mit.edu	37	11	57427353	57427353	+	Silent	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:57427353C>T	uc001nkw.2	+	2	544	c.405C>T	c.(403-405)CTC>CTT	p.L135L	CLP1_uc010rjw.1_Silent_p.L135L|CLP1_uc009yml.2_Silent_p.L135L	NM_006831	NP_006822	Q92989	CLP1_HUMAN	ATP/GTP-binding protein isoform 1	135					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			ovary(1)	1						GCCTTCTGCTCAACTACGCAG	0.597			NA											4	23					0	0	0.000602	0	0
TCN1	6947	broad.mit.edu	37	11	59622172	59622172	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:59622172G>T	uc001noj.2	-	7	1172	c.1074C>A	c.(1072-1074)TTC>TTA	p.F358L		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	358					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TCACACTGAGGAAGACAGAAC	0.383			NA											16	66					1.37522e-17	2.23297e-17	0.007413	1	0
AHNAK	79026	broad.mit.edu	37	11	62303495	62303495	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:62303495C>A	uc001ntl.2	-	3	376	c.76G>T	c.(76-78)GCC>TCC	p.A26S	AHNAK_uc001ntk.1_Missense_Mutation_p.A26S	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	26	PDZ.				nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCCCTCTGGGCGATGGTCAGC	0.637			NA											8	54					7.48243e-07	9.58116e-07	0.006214	1	0
SLC22A12	116085	broad.mit.edu	37	11	64359055	64359055	+	Silent	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:64359055C>T	uc001oam.1	+	1	774	c.27C>T	c.(25-27)CTC>CTT	p.L9L	SLC22A12_uc009ypr.1_Silent_p.L9L|SLC22A12_uc001oal.1_Intron|SLC22A12_uc009yps.1_Silent_p.L9L|SLC22A12_uc001oan.1_Silent_p.L9L|SLC22A12_uc009ypt.2_5'Flank	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	9	Helical; (Potential).				cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						TCCTGGACCTCGTGGGTGGCC	0.597			NA											12	75					0	0	0.00245	0	0
SUV420H1	51111	broad.mit.edu	37	11	67953299	67953299	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:67953299C>G	uc001onm.1	-	3	513	c.257G>C	c.(256-258)AGT>ACT	p.S86T	SUV420H1_uc009yse.1_5'UTR|SUV420H1_uc001onn.1_5'UTR|SUV420H1_uc009ysf.2_5'UTR|SUV420H1_uc001ono.1_Missense_Mutation_p.S86T|SUV420H1_uc001onp.2_Missense_Mutation_p.S86T|SUV420H1_uc010rqa.1_Missense_Mutation_p.S86T|SUV420H1_uc001onq.2_Missense_Mutation_p.S86T	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	86					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						AAGAACCAAACTGGTTGCTAG	0.393			NA											12	50					0	0	0.003163	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73078683	73078683	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:73078683C>T	uc001otu.2	+	21	6071	c.6050C>T	c.(6049-6051)CCC>CTC	p.P2017L		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	2017					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						CACCGAGGCCCCGCCCCTGCC	0.647			NA											15	72					0	0	0.003163	0	0
ME3	10873	broad.mit.edu	37	11	86209163	86209163	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:86209163C>A	uc001pbz.2	-	5	801	c.547G>T	c.(547-549)GTG>TTG	p.V183L	ME3_uc001pca.2_Missense_Mutation_p.V183L|ME3_uc009yvk.2_Missense_Mutation_p.V183L|ME3_uc010rtr.1_RNA	NM_001014811	NP_001014811	Q16798	MAON_HUMAN	mitochondrial malic enzyme 3 precursor	183					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			ovary(1)	1		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	GTCACCACCACGGCCTGAAAA	0.622			NA											10	69					2.27111e-07	3.00588e-07	0.001368	1	0
FOLH1B	219595	broad.mit.edu	37	11	89405081	89405081	+	Silent	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:89405081C>A	uc001pda.2	+	5	734	c.208C>A	c.(208-210)CGG>AGG	p.R70R		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	70					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GGGAGGTCACCGGGACTCATG	0.418			NA											5	44					3.59834e-05	4.39332e-05	0.001168	1	0
FAT3	120114	broad.mit.edu	37	11	92086148	92086148	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:92086148A>T	uc001pdj.3	+	1	887	c.870A>T	c.(868-870)TTA>TTT	p.L290F		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	290	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTGATGACTTAGATGATGGAG	0.443			NA								TCGA Ovarian(4;0.039)			3	37					0	0	0.000248	0	0
CARD16	114769	broad.mit.edu	37	11	104915304	104915304	+	Nonsense_Mutation	SNP	A	A	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:104915304A>C	uc001pip.1	-	2	116	c.89T>G	c.(88-90)TTA>TGA	p.L30*	CASP1_uc010rve.1_Intron|CASP1_uc010rvf.1_Intron|CASP1_uc010rvg.1_Intron|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron|CARD16_uc001pio.1_Nonsense_Mutation_p.L30*	NM_001017534	NP_001017534	Q5EG05	CAR16_HUMAN	caspase-1 dominant-negative inhibitor pseudo-ICE	30	CARD.				regulation of apoptosis	intracellular	cysteine-type endopeptidase inhibitor activity			skin(1)	1						CCTTGTCTGTAATAATTCATC	0.423			NA											50	178					0	0	0.00361	0	0
RAB39	54734	broad.mit.edu	37	11	107832694	107832694	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:107832694C>T	uc001pjt.2	+	2	268	c.250C>T	c.(250-252)CGC>TGC	p.R84C		NM_017516	NP_059986	Q14964	RB39A_HUMAN	RAB39, member RAS oncogene family	84					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0				BRCA - Breast invasive adenocarcinoma(274;3.04e-05)|Epithelial(105;8.56e-05)|all cancers(92;0.00179)		ATCTTATTACCGCAACTCAGT	0.353			NA											4	23					0	0	0.000602	0	0
OR10G8	219869	broad.mit.edu	37	11	123900657	123900657	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:123900657G>A	uc001pzp.1	+	1	328	c.328G>A	c.(328-330)GAG>AAG	p.E110K		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	110	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		AGGGGGCACCGAGTGTTTCCT	0.537			NA											11	96					0	0	0.008291	0	0
CCDC15	80071	broad.mit.edu	37	11	124857495	124857495	+	Missense_Mutation	SNP	A	A	C	rs113451248		TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr11:124857495A>C	uc001qbm.3	+	8	1632	c.1373A>C	c.(1372-1374)CAC>CCC	p.H458P		NM_025004	NP_079280	Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	458						centrosome				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		CATGTTCTCCACAAAGACCAA	0.418			NA											3	74					0	0	0.000248	0	0
GALNT8	26290	broad.mit.edu	37	12	4881637	4881637	+	Silent	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:4881637C>G	uc001qne.1	+	11	1880	c.1788C>G	c.(1786-1788)ACC>ACG	p.T596T		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	596	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						ACAGAGATACCAAGCGGTGTC	0.517	Colon(108;631 1558 7270 20097 39846)		NA											8	65					0	0	0.006214	0	0
CLEC4A	50856	broad.mit.edu	37	12	8276539	8276539	+	Missense_Mutation	SNP	A	A	G	rs36113649		TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:8276539A>G	uc001qtz.1	+	1	312	c.65A>G	c.(64-66)AAC>AGC	p.N22S	CLEC4A_uc009zga.1_Missense_Mutation_p.N22S|CLEC4A_uc001qub.1_Missense_Mutation_p.N22S|CLEC4A_uc001quc.1_Missense_Mutation_p.N22S|CLEC4A_uc009zgb.1_Missense_Mutation_p.N22S	NM_016184	NP_057268	Q9UMR7	CLC4A_HUMAN	C-type lectin domain family 4, member A isoform	22	Cytoplasmic (Potential).				cell adhesion|cell surface receptor linked signaling pathway|innate immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity				0				Kidney(36;0.0915)		TCAGGCATCAACACAGCCTCT	0.418			NA											28	45					0	0	0.003271	0	0
CD69	969	broad.mit.edu	37	12	9907713	9907713	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:9907713T>A	uc001qwk.2	-	3	413	c.332A>T	c.(331-333)AAT>ATT	p.N111I	CD69_uc010sgu.1_Missense_Mutation_p.N111I|CD69_uc010sgv.1_Missense_Mutation_p.N111I	NM_001781	NP_001772	Q07108	CD69_HUMAN	CD69 molecule	111	C-type lectin.|Extracellular (Potential).					integral to plasma membrane	sugar binding|transmembrane receptor activity				0						AGAACAAGCATTTTGGGCTGA	0.383			NA											29	53					0	0	0.006999	0	0
CLEC1A	51267	broad.mit.edu	37	12	10228148	10228148	+	Silent	SNP	A	A	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:10228148A>C	uc001qxb.2	-	4	582	c.498T>G	c.(496-498)CTT>CTG	p.L166L	CLEC1A_uc009zhf.2_Silent_p.L78L|CLEC1A_uc001qxc.2_Silent_p.L78L|CLEC1A_uc001qxd.2_Silent_p.L123L|CLEC1A_uc010sgx.1_Silent_p.L64L	NM_016511	NP_057595	Q8NC01	CLC1A_HUMAN	C-type lectin-like receptor-1	166	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane|intracellular	sugar binding|transmembrane receptor activity			ovary(1)|central_nervous_system(1)	2						AGTTTTCACTAAGGCAGAAAT	0.393			NA											26	47					0	0	0.00632	0	0
TAS2R42	353164	broad.mit.edu	37	12	11338798	11338798	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:11338798G>A	uc001qzr.1	-	1	746	c.746C>T	c.(745-747)TCC>TTC	p.S249F	PRB4_uc001qzf.1_Intron	NM_181429	NP_852094	Q7RTR8	T2R42_HUMAN	taste receptor, type 2, member 42	249	Helical; Name=6; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.0455)			CACTTGTAAGGAAAAAAAATG	0.418	Melanoma(15;352 722 10077 19546 48810)		NA											8	32					0	0	0.00308	0	0
PRB2	653247	broad.mit.edu	37	12	11546771	11546771	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:11546771G>C	uc010shk.1	-	3	276	c.241C>G	c.(241-243)CCA>GCA	p.P81A		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGTGGGGGTGGTCCTTGTGGC	0.612			NA											7	372					0	0	0.001984	0	0
KRAS	3845	broad.mit.edu	37	12	25380196	25380196	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:25380196T>A	uc001rgp.1	-	3	443	c.262A>T	c.(262-264)AAA>TAA	p.K88*	KRAS_uc001rgq.1_Nonsense_Mutation_p.K88*	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	88					activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding			large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			TCAAATGATTTAGTATTATTT	0.333	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)		119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			12	39					0	0	0.001855	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:25398284C>A	uc001rgp.1	-	2	216	c.35G>T	c.(34-36)GGT>GTT	p.G12V	KRAS_uc001rgq.1_Missense_Mutation_p.G12V|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			9	16					4.3838e-07	5.6827e-07	0.001855	1	0
DDX11	1663	broad.mit.edu	37	12	31236747	31236747	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:31236747G>T	uc001rjt.1	+	3	396	c.145G>T	c.(145-147)GGG>TGG	p.G49W	DDX11_uc010sjw.1_Missense_Mutation_p.G49W|DDX11_uc010sjx.1_RNA|DDX11_uc001rjr.1_Missense_Mutation_p.G49W|DDX11_uc001rjs.1_Missense_Mutation_p.G49W|DDX11_uc001rju.1_5'UTR|DDX11_uc001rjv.1_Missense_Mutation_p.G49W|DDX11_uc001rjw.1_Missense_Mutation_p.G23W	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	49	ATP (By similarity).|Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					CTTCCTGCAGGGGAAGTCCTT	0.443			NA								Multiple Myeloma(12;0.14)			4	42					8.12818e-05	9.80988e-05	0.001984	1	0
SYT10	341359	broad.mit.edu	37	12	33592396	33592396	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:33592396G>T	uc001rll.1	-	1	359	c.62C>A	c.(61-63)ACC>AAC	p.T21N	SYT10_uc009zju.1_5'UTR	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	21	Vesicular (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					GCACAGCTCGGTGACGATGTG	0.572			NA											76	170					2.02624e-56	3.48778e-56	0.00361	1	0
WIF1	11197	broad.mit.edu	37	12	65445163	65445163	+	Missense_Mutation	SNP	C	C	G	rs138241385		TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:65445163C>G	uc001ssk.2	-	10	1251	c.1106G>C	c.(1105-1107)CGG>CCG	p.R369P		NM_007191	NP_009122	Q9Y5W5	WIF1_HUMAN	WNT inhibitory factor 1 precursor	369					multicellular organismal development|Wnt receptor signaling pathway	extracellular region	protein tyrosine kinase activity			ovary(2)|lung(1)|skin(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0231)		TGGATCCCGCCGCTCCTCGGC	0.498	Esophageal Squamous(148;1595 1816 48559 49439 49664)		NA	T	HMGA2	pleomorphic salivary gland adenoma								12	34					0	0	0.001855	0	0
BEST3	144453	broad.mit.edu	37	12	70065291	70065291	+	Silent	SNP	G	G	A	rs113525790	by1000genomes	TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:70065291G>A	uc001svg.2	-	9	1244	c.1017C>T	c.(1015-1017)GAC>GAT	p.D339D	BEST3_uc001svd.1_Silent_p.D339D|BEST3_uc001sve.1_RNA|BEST3_uc001svf.2_Silent_p.D126D|BEST3_uc010stm.1_Silent_p.D233D|BEST3_uc001svh.2_Silent_p.D126D	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	339	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			CAGCAGAATCGTCCCAGTAAA	0.433			NA											5	49					0	0	0.001984	0	0
PPFIA2	8499	broad.mit.edu	37	12	81768487	81768487	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:81768487G>T	uc001szo.1	-	11	1353	c.1192C>A	c.(1192-1194)CAG>AAG	p.Q398K	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	324										ovary(3)|lung(2)|pancreas(1)	6						CTCATGGTCTGCTGCAACTTT	0.458			NA											5	27					0.000602214	0.000694863	0.000602	1	0
PLXNC1	10154	broad.mit.edu	37	12	94634438	94634438	+	Silent	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:94634438C>A	uc001tdc.2	+	11	2547	c.2298C>A	c.(2296-2298)ATC>ATA	p.I766I		NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	766	Extracellular (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						CCACCTGGATCAGGTACTTTC	0.388			NA											15	68					6.31663e-08	8.43109e-08	0.003163	1	0
GAS2L3	283431	broad.mit.edu	37	12	101012237	101012237	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:101012237G>C	uc001thu.2	+	8	746	c.520G>C	c.(520-522)GAG>CAG	p.E174Q	GAS2L3_uc009zty.2_Missense_Mutation_p.E174Q|GAS2L3_uc001thv.2_Missense_Mutation_p.E70Q	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	174					cell cycle arrest					skin(1)	1						ATACGGGGTTGAGCCACCAGT	0.393			NA											7	38					0	0	0.00308	0	0
STAB2	55576	broad.mit.edu	37	12	104089428	104089428	+	Splice_Site	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:104089428C>T	uc001tjw.2	+	32	3660	c.3474_splice	c.e32+2	p.I1158_splice		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor						angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						TACATCATTGCAAGTACCACA	0.512			NA											4	47					0	0	0.001168	0	0
TCP11L2	255394	broad.mit.edu	37	12	106729479	106729479	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:106729479T>G	uc001tln.2	+	7	1009	c.835T>G	c.(835-837)TCT>GCT	p.S279A		NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	t-complex 11 (mouse) like 2	279										ovary(3)	3						ATTTTCTCTTTCTGAGAGTGC	0.398			NA											4	35					0	0	0.000248	0	0
KNTC1	9735	broad.mit.edu	37	12	123082445	123082445	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:123082445C>A	uc001ucv.2	+	44	4686	c.4523C>A	c.(4522-4524)ACA>AAA	p.T1508K	KNTC1_uc010taf.1_Intron	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1508					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		CTGACGAGCACAAAAGATTTG	0.498			NA											7	58					0.000157383	0.000184984	0.00308	1	0
POLE	5426	broad.mit.edu	37	12	133220029	133220029	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr12:133220029T>A	uc001uks.1	-	34	4452	c.4408A>T	c.(4408-4410)ATG>TTG	p.M1470L	POLE_uc001ukq.1_5'Flank|POLE_uc001ukr.1_Missense_Mutation_p.M274L|POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Missense_Mutation_p.M1443L	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1470					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		AGAGAGCGCATCTCCAGGTGC	0.597			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					7	93					0	0	0.00308	0	0
RNF17	56163	broad.mit.edu	37	13	25370318	25370319	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr13:25370318_25370319CC>AA	uc001upr.2	+	11	1325_1326	c.1284_1285CC>AA	c.(1282-1287)TGCCAT>TGAAAT	p.428_429CH>*N	RNF17_uc010tdd.1_Nonsense_Mutation_p.287_288CH>*N|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Nonsense_Mutation_p.428_429CH>*N|RNF17_uc001ups.2_Nonsense_Mutation_p.367_368CH>*N|RNF17_uc001upq.1_3'UTR	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	428_429					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TAGATCCTTGCCATTTCTACAT	0.347			NA											3	56					0	0	0.004672	0	0
RXFP2	122042	broad.mit.edu	37	13	32356828	32356828	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr13:32356828T>G	uc001utt.2	+	11	944	c.873T>G	c.(871-873)AAT>AAG	p.N291K	RXFP2_uc010aba.2_Intron	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	291	LRR 7.|Extracellular (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		TGCCTAGAAATCAAATTGGTT	0.408			NA											6	39					0	0	0.00308	0	0
DIS3	22894	broad.mit.edu	37	13	73352425	73352425	+	Silent	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr13:73352425C>T	uc001vix.3	-	3	854	c.480G>A	c.(478-480)TTG>TTA	p.L160L	DIS3_uc001viy.3_Silent_p.L130L|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	160	PINc.				CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		ACATTTTTTTCAAATGTTCAT	0.373			NA								Multiple Myeloma(4;0.011)			4	27					0	0	0.000248	0	0
ZIC5	85416	broad.mit.edu	37	13	100617983	100617983	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr13:100617983C>A	uc001vom.1	-	2	1889	c.1640G>T	c.(1639-1641)AGT>ATT	p.S547I		NM_033132	NP_149123	Q96T25	ZIC5_HUMAN	zinc finger protein of the cerebellum 5	547					cell differentiation	nucleus	DNA binding|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GGGCTTGTCACTGGTGTGGAC	0.488			NA											9	67					0.00829132	0.00916409	0.008291	1	0
OR4M1	441670	broad.mit.edu	37	14	20248765	20248765	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr14:20248765G>T	uc010tku.1	+	1	284	c.284G>T	c.(283-285)GGT>GTT	p.G95V		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATTTCCTTTGGTGGATGCATT	0.463			NA											26	128					1.77063e-15	2.80276e-15	0.005443	1	0
RABGGTA	5875	broad.mit.edu	37	14	24738889	24738889	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr14:24738889C>A	uc001wof.2	-	5	861	c.439G>T	c.(439-441)GAC>TAC	p.D147Y	RABGGTA_uc001woe.2_RNA|RABGGTA_uc001wog.2_Missense_Mutation_p.D147Y|RABGGTA_uc001woh.2_RNA|RABGGTA_uc001woi.2_RNA	NM_004581	NP_004572	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase alpha	147	PFTA 3.				visual perception		Rab geranylgeranyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(265;0.0184)		CGCCGATAGTCCCAGCAGTGA	0.587			NA											9	26					0.000442599	0.000514461	0.006214	1	0
CTSG	1511	broad.mit.edu	37	14	25044576	25044576	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr14:25044576G>T	uc001wpq.2	-	2	135	c.98C>A	c.(97-99)CCC>CAC	p.P33H		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	33	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		CGCCATGTAGGGGCGGGAGTG	0.572			NA											17	141					5.45727e-16	8.72609e-16	0.008361	1	0
RTN1	6252	broad.mit.edu	37	14	60074098	60074098	+	Silent	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr14:60074098G>A	uc001xen.1	-	4	2087	c.1878C>T	c.(1876-1878)TAC>TAT	p.Y626Y	RTN1_uc001xem.1_Silent_p.Y206Y|RTN1_uc001xek.1_Silent_p.Y58Y|RTN1_uc001xel.1_RNA|RTN1_uc010apl.1_Silent_p.Y43Y	NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	626	Reticulon.				neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		CCAGGGCCAGGTAGGCCACGA	0.562			NA											6	43					0	0	0.001168	0	0
SMOC1	64093	broad.mit.edu	37	14	70442456	70442456	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr14:70442456T>A	uc001xls.1	+	4	656	c.403T>A	c.(403-405)TAC>AAC	p.Y135N	SMOC1_uc001xlt.1_Missense_Mutation_p.Y135N	NM_022137	NP_071420	Q9H4F8	SMOC1_HUMAN	secreted modular calcium-binding protein 1	135	Thyroglobulin type-1 1.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			upper_aerodigestive_tract(1)|pancreas(1)	2				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		TTACACTGGGTACTGCTGGTG	0.502			NA											11	55					0	0	0.00245	0	0
TMED10	10972	broad.mit.edu	37	14	75614413	75614413	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr14:75614413A>T	uc001xrm.1	-	3	432	c.365T>A	c.(364-366)GTG>GAG	p.V122E	TMED10_uc010ash.1_RNA|TMED10_uc010asg.1_RNA|TMED10_uc010tuz.1_5'UTR	NM_006827	NP_006818	P49755	TMEDA_HUMAN	transmembrane emp24 domain-containing protein 10	122	Lumenal (Potential).|GOLD.				protein transport|regulated secretory pathway|vesicle targeting, to, from or within Golgi	cis-Golgi network|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|melanosome|microsome|zymogen granule membrane	protein binding				0				BRCA - Breast invasive adenocarcinoma(234;0.0126)		GTCTAGGATCACGAGTTGGTC	0.483			NA											48	172					0	0	0.00361	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102483598	102483598	+	Silent	SNP	T	T	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr14:102483598T>C	uc001yks.2	+	39	8186	c.8022T>C	c.(8020-8022)TAT>TAC	p.Y2674Y	DYNC1H1_uc001ykt.1_Silent_p.Y165Y	NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	2674	AAA 3 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						TGGATAAATATGGGACCCAGA	0.453			NA											17	59					0	0	0.008871	0	0
PACS2	23241	broad.mit.edu	37	14	105833558	105833558	+	Silent	SNP	A	A	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr14:105833558A>G	uc001yqt.2	+	5	607	c.432A>G	c.(430-432)CAA>CAG	p.Q144Q	PACS2_uc001yqs.2_Silent_p.Q77Q|PACS2_uc001yqv.2_Silent_p.Q144Q|PACS2_uc001yqu.2_Silent_p.Q144Q	NM_015197	NP_056012	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	144					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				pancreas(1)	1		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		AGGTGATGCAACACCCGTCTG	0.642			NA											6	29					0	0	0.001168	0	0
C14orf80	283643	broad.mit.edu	37	14	105960174	105960174	+	Silent	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr14:105960174C>T	uc001yrm.2	+	5	715	c.588C>T	c.(586-588)ATC>ATT	p.I196I	C14orf80_uc001yrj.2_Intron|C14orf80_uc001yrk.2_Intron|C14orf80_uc001yrn.2_Silent_p.I196I|C14orf80_uc001yro.2_Intron|C14orf80_uc010tys.1_Silent_p.I18I	NM_001134875	NP_001128347	Q86SX3	CN080_HUMAN	hypothetical protein LOC283643 isoform 1	196											0		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0188)	Epithelial(152;0.239)		TGTTTTAGATCCACCTGTACA	0.602			NA											5	32					0	0	0.001984	0	0
GABRG3	2567	broad.mit.edu	37	15	27222209	27222209	+	Silent	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr15:27222209G>A	uc001zbg.1	+	2	280	c.114G>A	c.(112-114)TTG>TTA	p.L38L	GABRG3_uc001zbf.2_Silent_p.L38L	NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	38	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		AGTGGGTCTTGGCTCCAAAAT	0.418	NSCLC(114;800 1656 7410 37729 45293)		NA											9	28					0	0	0.004482	0	0
GABRG3	2567	broad.mit.edu	37	15	27777771	27777771	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr15:27777771C>A	uc001zbg.1	+	10	1314	c.1148C>A	c.(1147-1149)CCA>CAA	p.P383Q		NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	383	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		GACATGAGGCCACCACCAACT	0.433	NSCLC(114;800 1656 7410 37729 45293)		NA											7	27					8.12818e-05	9.80988e-05	0.001984	1	0
MTMR10	54893	broad.mit.edu	37	15	31233850	31233850	+	Silent	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr15:31233850G>A	uc001zfh.1	-	16	2255	c.2157C>T	c.(2155-2157)AAC>AAT	p.N719N	MTMR15_uc001zff.2_3'UTR|MTMR15_uc001zfe.2_3'UTR|MTMR10_uc010ubk.1_Silent_p.N133N|MTMR10_uc001zfg.1_Silent_p.N300N|MTMR10_uc010azx.1_Silent_p.N471N|MTMR10_uc001zfi.1_3'UTR	NM_017762	NP_060232	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	719							phosphatase activity			ovary(1)	1		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		GGCCGCTGGCGTTGAAGTACA	0.587			NA											3	6					0	0	0.004672	0	0
SEMA6D	80031	broad.mit.edu	37	15	48063809	48063809	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr15:48063809G>A	uc010bek.2	+	19	3409	c.3049G>A	c.(3049-3051)GTG>ATG	p.V1017M	SEMA6D_uc001zvw.2_Missense_Mutation_p.V955M|SEMA6D_uc001zvy.2_Missense_Mutation_p.V1017M|SEMA6D_uc001zvz.2_Missense_Mutation_p.V961M|SEMA6D_uc001zwa.2_3'UTR|SEMA6D_uc001zwb.2_Missense_Mutation_p.V955M|SEMA6D_uc001zwc.2_Missense_Mutation_p.V942M	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	1017	Cytoplasmic (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		GGGAACACCAGTGAGTGTTCA	0.517			NA											24	100					0	0	0.007291	0	0
CEP152	22995	broad.mit.edu	37	15	49059641	49059641	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr15:49059641G>A	uc001zwy.2	-	16	2072	c.2038C>T	c.(2038-2040)CAG>TAG	p.Q680*	CEP152_uc001zwz.2_Nonsense_Mutation_p.Q680*|CEP152_uc001zxa.1_Nonsense_Mutation_p.Q587*	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	680					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		TCATGGTGCTGCTGATAAGTC	0.443			NA											7	54					0	0	0.004482	0	0
THSD4	79875	broad.mit.edu	37	15	72040905	72040905	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr15:72040905G>T	uc002atb.1	+	13	2466	c.2387G>T	c.(2386-2388)AGC>ATC	p.S796I	THSD4_uc002ate.2_Missense_Mutation_p.S436I	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	796	TSP type-1 4.					proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						TGTGCCAAGAGCTGGTTCCTC	0.572			NA											7	37					7.48243e-07	9.58116e-07	0.006214	1	0
ACSBG1	23205	broad.mit.edu	37	15	78474874	78474874	+	Silent	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr15:78474874G>A	uc002bdh.2	-	7	884	c.828C>T	c.(826-828)TGC>TGT	p.C276C	ACSBG1_uc010umw.1_Silent_p.C272C|ACSBG1_uc010umx.1_Silent_p.C34C|ACSBG1_uc010umy.1_Silent_p.C169C	NM_015162	NP_055977	Q96GR2	ACBG1_HUMAN	lipidosin	276					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1						CTAGCACACAGCACTGGTTGG	0.592			NA											3	32					0	0	0.000248	0	0
NTRK3	4916	broad.mit.edu	37	15	88678344	88678344	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr15:88678344C>G	uc002bme.1	-	9	1354	c.1192G>C	c.(1192-1194)GAG>CAG	p.E398Q	NTRK3_uc002bmh.2_Missense_Mutation_p.E398Q|NTRK3_uc002bmf.1_Missense_Mutation_p.E398Q|NTRK3_uc010upl.1_Missense_Mutation_p.E300Q|NTRK3_uc010bnh.1_Missense_Mutation_p.E398Q|NTRK3_uc002bmg.2_Missense_Mutation_p.E398Q	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	398	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGAAAGGGCTCCTTGAGGAAG	0.532			NA	T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			15	78					0	0	0.00499	0	0
Unknown	0	broad.mit.edu	37	15	102292767	102292767	+	Nonsense_Mutation	SNP	C	C	T	rs113047734	by1000genomes	TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr15:102292767C>T	uc010usj.1	+	4	414	c.355C>T	c.(355-357)CGA>TGA	p.R119*	uc002bxp.3_5'Flank|uc002bxt.2_5'Flank|uc002bxz.3_5'Flank|uc002byd.2_5'Flank|uc002bye.2_5'Flank|uc002byf.1_5'Flank|uc002byg.2_5'Flank|uc002byi.2_5'Flank|uc002byk.2_5'Flank|uc002bym.2_5'Flank|uc002byn.2_5'Flank|uc010usm.1_5'Flank					RecName: Full=Uncharacterized protein C15orf51.; Flags: Fragment;												NA						CACAGCGGCGCGACGAGATGC	0.597			NA											6	23					0	0	0.00245	0	0
Unknown	0	broad.mit.edu	37	15	102292785	102292785	+	Missense_Mutation	SNP	C	C	G	rs143389223		TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr15:102292785C>G	uc010usj.1	+	4	432	c.373C>G	c.(373-375)CAG>GAG	p.Q125E	uc002bxp.3_5'Flank|uc002bxt.2_5'Flank|uc002bxz.3_5'Flank|uc002byd.2_5'Flank|uc002bye.2_5'Flank|uc002byf.1_5'Flank|uc002byg.2_5'Flank|uc002byi.2_5'Flank|uc002byk.2_5'Flank|uc002bym.2_5'Flank|uc002byn.2_5'Flank|uc010usm.1_5'Flank					RecName: Full=Uncharacterized protein C15orf51.; Flags: Fragment;												NA						TGCTGCTTCTCAGAGCTGCTG	0.602			NA											3	28					0	0	0.00308	0	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr15:102515299G>A	uc002cdi.2	+	9	1943	c.523G>A	c.(523-525)GGC>AGC	p.G175S	WASH3P_uc002cdl.2_Missense_Mutation_p.G175S|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.G175S|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						TGGGGGCATCGGCAAGGCCAA	0.652			NA											2	13					0	0	0.004672	0	0
ABAT	18	broad.mit.edu	37	16	8868846	8868846	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr16:8868846G>T	uc002czc.3	+	13	1220	c.1054G>T	c.(1054-1056)GTG>TTG	p.V352L	ABAT_uc002czd.3_Missense_Mutation_p.V352L|ABAT_uc010buh.2_Missense_Mutation_p.V294L|ABAT_uc010bui.2_Missense_Mutation_p.V352L	NM_020686	NP_065737	P80404	GABT_HUMAN	4-aminobutyrate aminotransferase precursor	352					behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			upper_aerodigestive_tract(1)	1					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	CCCAGCAGACGTGATGACCTT	0.582			NA											11	48					2.61681e-11	3.81619e-11	0.00245	1	0
SLC6A2	6530	broad.mit.edu	37	16	55729223	55729223	+	Silent	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr16:55729223C>T	uc002eif.2	+	8	1167	c.1056C>T	c.(1054-1056)ATC>ATT	p.I352I	SLC6A2_uc010ccd.2_Silent_p.I352I|SLC6A2_uc002eig.2_Silent_p.I352I|SLC6A2_uc002eih.2_Silent_p.I352I|SLC6A2_uc002eii.2_Silent_p.I247I|SLC6A2_uc002eij.2_Silent_p.I66I	NM_001043	NP_001034	P23975	SC6A2_HUMAN	solute carrier family 6 member 2	352	Helical; Name=7; (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			lung(4)|ovary(2)|pancreas(2)	8				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	TCAACTGTATCACCAGCTTCG	0.547			NA											10	86					0	0	0.00245	0	0
RSPRY1	89970	broad.mit.edu	37	16	57265200	57265200	+	Silent	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr16:57265200C>T	uc002elb.2	+	13	1776	c.1498C>T	c.(1498-1500)CTA>TTA	p.L500L	RSPRY1_uc002elc.2_Silent_p.L500L|RSPRY1_uc002eld.2_Silent_p.L500L	NM_133368	NP_588609	Q96DX4	RSPRY_HUMAN	ring finger and SPRY domain containing 1	500						extracellular region	zinc ion binding			ovary(1)	1						CTACGCCTTCCTAACAGCTGA	0.338			NA											6	55					0	0	0.001984	0	0
CSNK2A2	1459	broad.mit.edu	37	16	58220711	58220711	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr16:58220711A>C	uc002enc.2	-	3	408	c.266T>G	c.(265-267)CTT>CGT	p.L89R		NM_001896	NP_001887	P19784	CSK22_HUMAN	casein kinase 2, alpha prime polypeptide	89	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|nucleus	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						TCCACCACGAAGGTTCTCCAG	0.413	Melanoma(54;119 1219 18349 35700 39738)		NA											18	88					0	0	0.001523	0	0
ZNF19	7567	broad.mit.edu	37	16	71509851	71509851	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr16:71509851C>A	uc010cgc.1	-	6	1105	c.599G>T	c.(598-600)GGT>GTT	p.G200V	ZNF23_uc002fai.2_Intron|ZNF19_uc002fak.1_Missense_Mutation_p.G188V|ZNF19_uc002fal.1_Missense_Mutation_p.G188V|ZNF19_uc002fam.1_Missense_Mutation_p.G200V	NM_006961	NP_008892	P17023	ZNF19_HUMAN	zinc finger protein 19	200	C2H2-type 2.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(137;0.00965)		BRCA - Breast invasive adenocarcinoma(221;0.0161)|Kidney(780;0.0598)		CGAAGAATTACCATTAAAGGC	0.443			NA											5	30					1.6384e-10	2.3566e-10	0.001984	1	0
CHST5	23563	broad.mit.edu	37	16	75563351	75563351	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr16:75563351G>A	uc002fei.2	-	3	2327	c.932C>T	c.(931-933)GCC>GTC	p.A311V	CHST5_uc002fej.1_Missense_Mutation_p.A317V	NM_024533	NP_078809	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	311	Lumenal (Potential).				N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						GCCGGTGAAGGCGTAGAGTGC	0.677			NA											19	96					0	0	0.002299	0	0
TP53	7157	broad.mit.edu	37	17	7578498	7578498	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr17:7578498C>A	uc002gim.2	-	5	626	c.432G>T	c.(430-432)CAG>CAT	p.Q144H	TP53_uc002gig.1_Missense_Mutation_p.Q144H|TP53_uc002gih.2_Missense_Mutation_p.Q144H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Q12H|TP53_uc010cng.1_Missense_Mutation_p.Q12H|TP53_uc002gii.1_Missense_Mutation_p.Q12H|TP53_uc010cnh.1_Missense_Mutation_p.Q144H|TP53_uc010cni.1_Missense_Mutation_p.Q144H|TP53_uc002gij.2_Missense_Mutation_p.Q144H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Q51H|TP53_uc002gio.2_Missense_Mutation_p.Q12H|TP53_uc010vug.1_Missense_Mutation_p.Q105H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	144	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> P (in sporadic cancers; somatic mutation).|Q -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q144*(29)|p.Q144L(8)|p.0?(7)|p.Q144H(4)|p.Q144P(4)|p.Q144R(4)|p.Q144fs*26(3)|p.Q144K(2)|p.Q144del(2)|p.Q144Q(2)|p.Q144_G154del11(1)|p.L137_W146del10(1)|p.Q144fs*32(1)|p.Q144fs*16(1)|p.Q144fs*4(1)|p.P142_Q144delPVQ(1)|p.V143_S149del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAACCCACAGCTGCACAGGGC	0.602	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	45					0.00400662	0.00449141	0.004007	1	0
MYH2	4620	broad.mit.edu	37	17	10447064	10447064	+	Silent	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr17:10447064G>A	uc010coi.2	-	8	833	c.705C>T	c.(703-705)AAC>AAT	p.N235N	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.N235N|MYH2_uc010coj.2_Silent_p.N235N	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	235	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CGGTCTTGGCGTTGCCAAAGG	0.478			NA											11	39					0	0	0.00245	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319335	21319335	+	Silent	SNP	T	T	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr17:21319335T>C	uc002gyv.1	+	3	1386	c.681T>C	c.(679-681)CAT>CAC	p.H227H		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	227	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	TGGAGGCCCATGTGCGCGCGC	0.642			NA								Prostate(3;0.18)			17	46					0	0	0.007413	0	0
PIGS	94005	broad.mit.edu	37	17	26888618	26888618	+	Silent	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr17:26888618C>T	uc002hbo.2	-	6	871	c.498G>A	c.(496-498)AGG>AGA	p.R166R	PIGS_uc002hbn.2_Silent_p.R158R|PIGS_uc010wap.1_Silent_p.R105R	NM_033198	NP_149975	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	166	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(2)|urinary_tract(1)|kidney(1)	4	Lung NSC(42;0.00431)					CCACTGCTGTCCTCTTGGGCC	0.562			NA											3	22					0	0	0.000248	0	0
KRT33A	3883	broad.mit.edu	37	17	39502461	39502461	+	Silent	SNP	G	G	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr17:39502461G>C	uc002hwk.1	-	7	1162	c.1125C>G	c.(1123-1125)ACC>ACG	p.T375T		NM_004138	NP_004129	O76009	KT33A_HUMAN	keratin 33A	375	Tail.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				CACATGCATTGGTTGTGGCGC	0.512			NA											3	82					0	0	0.004672	0	0
CDC27	996	broad.mit.edu	37	17	45219643	45219643	+	Missense_Mutation	SNP	T	T	C	rs77510601		TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr17:45219643T>C	uc002ild.3	-	11	1457	c.1330A>G	c.(1330-1332)ACA>GCA	p.T444A	CDC27_uc002ile.3_Missense_Mutation_p.T450A|CDC27_uc002ilf.3_Missense_Mutation_p.T444A|CDC27_uc010wkp.1_Missense_Mutation_p.T383A|CDC27_uc010wkq.1_Intron	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	444					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						GGTGTGATTGTGGATATTTTC	0.308			NA											4	30					0	0	0.000248	0	0
PPP1R9B	84687	broad.mit.edu	37	17	48216665	48216665	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr17:48216665G>A	uc002iqh.3	-	9	2039	c.2036C>T	c.(2035-2037)GCG>GTG	p.A679V		NM_032595	NP_115984	Q96SB3	NEB2_HUMAN	protein phosphatase 1, regulatory subunit 9B	677	Potential.|Interacts with TGN38 (By similarity).				cell cycle arrest|cell differentiation|cell migration|filopodium assembly|negative regulation of cell growth|nervous system development|regulation of cell growth by extracellular stimulus|regulation of cell proliferation|regulation of exit from mitosis|RNA splicing	adherens junction|cytoskeleton|dendritic spine|filopodium|lamellipodium|nucleoplasm|protein phosphatase type 1 complex|ruffle membrane|synapse	actin binding|protein phosphatase 1 binding|protein phosphatase inhibitor activity				0						CTCAGTGACCGCATGCTTGAT	0.498			NA											4	202					0	0	0.000602	0	0
TOB1	10140	broad.mit.edu	37	17	48940956	48940956	+	Silent	SNP	G	G	A	rs142180537		TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr17:48940956G>A	uc002isw.2	-	1	458	c.423C>T	c.(421-423)CCC>CCT	p.P141P	TOB1_uc010wmy.1_Silent_p.P141P|TOB1_uc010wmz.1_Silent_p.P141P	NM_005749	NP_005740	P50616	TOB1_HUMAN	transducer of ERBB2, 1	141					negative regulation of cell proliferation		SH3/SH2 adaptor activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GGTCACTTATGGGCATAAAAA	0.488	NSCLC(144;643 1919 24513 29423 40686)		NA									OREG0024576	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	45					0	0	0.001368	0	0
SFRS1	6426	broad.mit.edu	37	17	56082810	56082810	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr17:56082810G>A	uc002ivi.2	-	4	913	c.704C>T	c.(703-705)CCA>CTA	p.P235L	SFRS1_uc002ivj.2_3'UTR	NM_006924	NP_008855	Q07955	SRSF1_HUMAN	splicing factor, arginine/serine-rich 1 isoform	235	Arg/Ser-rich (RS domain).|Interacts with SAFB1.			Missing: In RS-C; loss of ability to activate splicing but retains splice site switching.|Missing: In MR-A; loss of ability to activate splicing.|Missing: In MR-B; strongly inhibits splicing.|Missing: In RS-B; retains both splice activation and splice site switching activity.	mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA 5'-splice site recognition|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytoplasm|nuclear speck	nucleotide binding|RNA binding				0		Colorectal(1115;0.0691)		LUAD - Lung adenocarcinoma(1115;0.247)		AGAATAGCGTGGTGATCCTCT	0.473			NA											68	191					0	0	0.00361	0	0
CDC42EP4	23580	broad.mit.edu	37	17	71281643	71281643	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr17:71281643C>A	uc002jjn.2	-	2	1144	c.997G>T	c.(997-999)GCT>TCT	p.A333S	CDC42EP4_uc002jjo.2_Missense_Mutation_p.A333S|CDC42EP4_uc002jjp.1_Missense_Mutation_p.A263S	NM_012121	NP_036253	Q9H3Q1	BORG4_HUMAN	Cdc42 effector protein 4	333					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|cytoplasm|endomembrane system|membrane|microtubule cytoskeleton	GTP-Rho binding				0			LUSC - Lung squamous cell carcinoma(166;0.0352)|Lung(188;0.0711)			GAGACAGCAGCCCGGGCCCTG	0.657			NA											28	81					3.73148e-12	5.54441e-12	0.007291	1	0
FOXK2	3607	broad.mit.edu	37	17	80543836	80543836	+	Missense_Mutation	SNP	G	G	T	rs139089969		TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr17:80543836G>T	uc002kfn.2	+	7	1507	c.1336G>T	c.(1336-1338)GCC>TCC	p.A446S	FOXK2_uc002kfm.1_Missense_Mutation_p.A446S|FOXK2_uc010diu.2_Intron	NM_004514	NP_004505	Q01167	FOXK2_HUMAN	forkhead box K2	446					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			GCTACCACAGGCCATCAAGCC	0.587			NA											31	77					1.36615e-20	2.26493e-20	0.002836	1	0
ZNF521	25925	broad.mit.edu	37	18	22804575	22804575	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr18:22804575C>A	uc002kvk.2	-	4	3554	c.3307G>T	c.(3307-3309)GCC>TCC	p.A1103S	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.A1103S|ZNF521_uc002kvl.2_Missense_Mutation_p.A883S	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	1103					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					CCTGGGCTGGCGCTCTTACTG	0.537			NA	T	PAX5	ALL								17	61					2.94398e-08	3.96305e-08	0.007413	1	0
CDH2	1000	broad.mit.edu	37	18	25572690	25572690	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr18:25572690C>G	uc002kwg.2	-	9	1732	c.1273G>C	c.(1273-1275)GGA>CGA	p.G425R	CDH2_uc010xbn.1_Missense_Mutation_p.G394R	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	425	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						GTAGGATCTCCGCCACTGATT	0.522			NA											12	75					0	0	0.001855	0	0
CD209	30835	broad.mit.edu	37	19	7810766	7810766	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr19:7810766C>T	uc002mht.2	-	4	453	c.386G>A	c.(385-387)CGG>CAG	p.R129Q	CD209_uc010xju.1_Intron|CD209_uc010dvp.2_Missense_Mutation_p.R105Q|CD209_uc002mhr.2_Missense_Mutation_p.R105Q|CD209_uc002mhs.2_Missense_Mutation_p.R105Q|CD209_uc002mhu.2_Missense_Mutation_p.R129Q|CD209_uc010dvq.2_Missense_Mutation_p.R129Q|CD209_uc002mhq.2_Missense_Mutation_p.R129Q|CD209_uc002mhv.2_Missense_Mutation_p.R105Q|CD209_uc002mhx.2_Missense_Mutation_p.R85Q|CD209_uc002mhw.2_Missense_Mutation_p.R85Q|CD209_uc010dvr.2_Intron	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	129	Extracellular (Probable).|2.|7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						AGCCTTCAGCCGGGTCAGCTC	0.567			NA											4	141					0	0	0.000602	0	0
CPAMD8	27151	broad.mit.edu	37	19	17100505	17100505	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr19:17100505T>A	uc002nfb.2	-	13	1516	c.1484A>T	c.(1483-1485)TAC>TTC	p.Y495F		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	448						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						GCTGGGGGAGTACCAGCTGCC	0.587			NA											14	51					0	0	0.00245	0	0
ZNF382	84911	broad.mit.edu	37	19	37117917	37117917	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr19:37117917C>A	uc002oek.2	+	5	1231	c.1118C>A	c.(1117-1119)ACA>AAA	p.T373K	ZNF382_uc010efa.2_Missense_Mutation_p.T324K|ZNF382_uc010efb.2_Missense_Mutation_p.T372K|ZNF382_uc002oel.2_Missense_Mutation_p.T372K	NM_032825	NP_116214	Q96SR6	ZN382_HUMAN	zinc finger protein 382	373	Required for transcriptional repression activity; probably mediates sequence- specific DNA-binding (By similarity).|C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CATCACAAAACACATACGGGG	0.458			NA											9	61					0.000673444	0.000768605	0.008291	1	0
HNRNPUL1	11100	broad.mit.edu	37	19	41779913	41779913	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr19:41779913A>C	uc002oqb.3	+	4	888	c.599A>C	c.(598-600)GAA>GCA	p.E200A	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Missense_Mutation_p.E100A|HNRNPUL1_uc002oqa.3_Missense_Mutation_p.E100A|HNRNPUL1_uc010ehm.2_Missense_Mutation_p.E200A|HNRNPUL1_uc002oqc.3_Missense_Mutation_p.E157A|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Missense_Mutation_p.E100A|HNRNPUL1_uc010ehn.2_Missense_Mutation_p.E100A|HNRNPUL1_uc010eho.2_Missense_Mutation_p.E100A|HNRNPUL1_uc010xvy.1_Missense_Mutation_p.E100A|HNRNPUL1_uc010ehp.2_Missense_Mutation_p.E56A|HNRNPUL1_uc010ehl.1_Missense_Mutation_p.E100A	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	200	B30.2/SPRY.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						CCTCCTGCTGAAGAGGATGAA	0.433			NA											12	59					0	0	0.004007	0	0
ZNF221	7638	broad.mit.edu	37	19	44470922	44470922	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr19:44470922A>T	uc002oxx.2	+	6	1596	c.1268A>T	c.(1267-1269)AAA>ATA	p.K423I	ZNF221_uc010ejb.1_Missense_Mutation_p.K423I|ZNF221_uc010xws.1_Missense_Mutation_p.K423I	NM_013359	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	423	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Prostate(69;0.0352)				AAATCCTTCAAATGTGAAGAA	0.413			NA											10	36					0	0	0.000978	0	0
PTPRH	5794	broad.mit.edu	37	19	55713588	55713588	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr19:55713588T>A	uc002qjq.2	-	6	1062	c.989A>T	c.(988-990)TAC>TTC	p.Y330F	PTPRH_uc010esv.2_Missense_Mutation_p.Y152F|PTPRH_uc002qjs.2_Missense_Mutation_p.Y337F	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	330	Extracellular (Potential).|Fibronectin type-III 4.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		CTCAACCCCGTAGGTGGAGTT	0.582			NA											17	85					0	0	0.006122	0	0
AURKC	6795	broad.mit.edu	37	19	57746650	57746650	+	Silent	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr19:57746650G>T	uc002qoe.2	+	7	984	c.795G>T	c.(793-795)GGG>GGT	p.G265G	AURKC_uc002qoc.2_Silent_p.G246G|AURKC_uc002qod.2_Silent_p.G231G|AURKC_uc010etv.2_Silent_p.G262G	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	265	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		TGCCTCTGGGGGCCCGGGACT	0.532			NA											9	22					2.17888e-05	2.68104e-05	0.006214	1	0
ZIK1	284307	broad.mit.edu	37	19	58102405	58102405	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr19:58102405G>T	uc002qpg.2	+	4	1323	c.1226G>T	c.(1225-1227)TGT>TTT	p.C409F	ZNF547_uc002qpm.3_Intron|ZIK1_uc002qph.2_Missense_Mutation_p.C354F|ZIK1_uc002qpi.2_Missense_Mutation_p.C396F|ZIK1_uc002qpj.2_Missense_Mutation_p.C306F	NM_001010879	NP_001010879	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein	409	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CCTTATAAGTGTGGTGACTGT	0.458			NA											5	32					1.23904e-05	1.5366e-05	0.000602	1	0
ZIK1	284307	broad.mit.edu	37	19	58102412	58102412	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr19:58102412C>A	uc002qpg.2	+	4	1330	c.1233C>A	c.(1231-1233)GAC>GAA	p.D411E	ZNF547_uc002qpm.3_Intron|ZIK1_uc002qph.2_Missense_Mutation_p.D356E|ZIK1_uc002qpi.2_Missense_Mutation_p.D398E|ZIK1_uc002qpj.2_Missense_Mutation_p.D308E	NM_001010879	NP_001010879	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein	411	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AGTGTGGTGACTGTGGGAAAT	0.448			NA											3	31					0.004672	0.00518197	0.004672	1	0
DDX1	1653	broad.mit.edu	37	2	15760486	15760486	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:15760486G>T	uc002rce.2	+	17	1649	c.1361G>T	c.(1360-1362)AGA>ATA	p.R454I	DDX1_uc010yjq.1_Missense_Mutation_p.R362I	NM_004939	NP_004930	Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	454	Necessary for interaction with RELA.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		AAAACTGACAGACTCTGGGAA	0.373			NA											7	25					0.000157383	0.000184984	0.00308	1	0
OTOF	9381	broad.mit.edu	37	2	26712109	26712109	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:26712109T>C	uc002rhk.2	-	11	1142	c.1015A>G	c.(1015-1017)ATG>GTG	p.M339V		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	339	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCACGTCCATTTTGAAGGAG	0.622	GBM(102;732 1451 20652 24062 31372)		NA											5	20					0	0	0.001984	0	0
EML4	27436	broad.mit.edu	37	2	42488428	42488428	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:42488428C>T	uc002rsi.2	+	4	768	c.506C>T	c.(505-507)ACC>ATC	p.T169I	EML4_uc002rsh.3_Missense_Mutation_p.T169I|EML4_uc010fap.2_Intron	NM_019063	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	169					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250						GCTACTCCCACCAAAAGGTTT	0.433			NA	T	ALK	NSCLC								12	108					0	0	0.003163	0	0
LRPPRC	10128	broad.mit.edu	37	2	44204415	44204415	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:44204415C>A	uc002rtr.2	-	4	528	c.470G>T	c.(469-471)GGT>GTT	p.G157V	LRPPRC_uc010yob.1_Missense_Mutation_p.G57V|LRPPRC_uc010faw.1_Missense_Mutation_p.G131V	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	157	PPR 1.				mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				ATACACAGCACCTACAAATGA	0.289			NA											12	35					4.3838e-07	5.6827e-07	0.001855	1	0
USP34	9736	broad.mit.edu	37	2	61516014	61516014	+	Splice_Site	SNP	T	T	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:61516014T>G	uc002sbe.2	-	34	4571	c.4549_splice	c.e34-1	p.W1517_splice		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34						positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			TAGCTGCCACTGTAAATGAGA	0.338			NA											13	52					0	0	0.004007	0	0
SPRED2	200734	broad.mit.edu	37	2	65571931	65571931	+	Silent	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:65571931C>A	uc002sdr.3	-	2	661	c.126G>T	c.(124-126)GGG>GGT	p.G42G	SPRED2_uc010fcw.2_Silent_p.G39G|SPRED2_uc010fcx.1_RNA	NM_181784	NP_861449	Q7Z698	SPRE2_HUMAN	sprouty-related protein with EVH-1 domain 2	42	WH1.				inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			ovary(1)|lung(1)|central_nervous_system(1)	3						CCTTACAGACCCCGACGCGAC	0.542			NA											13	29					4.3838e-07	5.6827e-07	0.001855	1	0
REG1B	5968	broad.mit.edu	37	2	79313983	79313983	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:79313983G>T	uc002sny.2	-	3	250	c.138C>A	c.(136-138)TAC>TAA	p.Y46*	REG1B_uc010ffv.1_Nonsense_Mutation_p.Y46*|REG1B_uc010ffw.2_Nonsense_Mutation_p.Y46*	NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	46	C-type lectin.				cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|skin(1)	2						AGTAGTAGCAGTAGGAGCGAT	0.517			NA											37	107					3.61848e-18	5.96765e-18	0.007835	1	0
LRRTM1	347730	broad.mit.edu	37	2	80530209	80530209	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:80530209C>A	uc002sok.1	-	2	1006	c.736G>T	c.(736-738)GCC>TCC	p.A246S	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	246	LRR 7.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						ACCACAATGGCCACCTTGTTC	0.587			NA								HNSCC(69;0.2)			16	80					6.49762e-13	9.79306e-13	0.006122	1	0
POLR1A	25885	broad.mit.edu	37	2	86258460	86258460	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:86258460C>A	uc002sqs.2	-	30	4950	c.4571G>T	c.(4570-4572)TGG>TTG	p.W1524L	POLR1A_uc010ytb.1_Missense_Mutation_p.W890L	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	1524					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						GACCTGGCACCACAGGCTCTC	0.657			NA											33	78					1.07637e-12	1.61455e-12	0.004878	1	0
GPR148	344561	broad.mit.edu	37	2	131487520	131487520	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:131487520C>T	uc002trv.1	+	1	798	c.796C>T	c.(796-798)CAC>TAC	p.H266Y		NM_207364	NP_997247	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	266	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1	Colorectal(110;0.1)					CCTGCTGATCCACTCAGTGCT	0.567			NA											24	92					0	0	0.00632	0	0
POTEE	445582	broad.mit.edu	37	2	132021446	132021446	+	Silent	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:132021446C>T	uc002tsn.2	+	15	2470	c.2418C>T	c.(2416-2418)ACC>ACT	p.T806T	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Silent_p.T406T|POTEE_uc002tsl.2_Silent_p.T388T|POTEE_uc010fmy.1_Silent_p.T270T	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	806	Actin-like.						ATP binding				0						TCCTGCTGACCGAGGCCCCCC	0.597			NA											34	116					0	0	0.003214	0	0
NCKAP5	344148	broad.mit.edu	37	2	133539542	133539542	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:133539542T>A	uc002ttp.2	-	14	5216	c.4842A>T	c.(4840-4842)AAA>AAT	p.K1614N	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1614							protein binding				0						TGAAGGTGTCTTTCGTTGAAC	0.428			NA											23	59					0	0	0.001786	0	0
MGAT5	4249	broad.mit.edu	37	2	135107399	135107399	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:135107399C>T	uc002ttv.1	+	9	1281	c.1136C>T	c.(1135-1137)TCA>TTA	p.S379L		NM_002410	NP_002401	Q09328	MGT5A_HUMAN	N-acetylglucosaminyltransferase V	379	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0964)		GTCCTTGATTCATTTGGTACT	0.423			NA											11	77					0	0	0.000978	0	0
ACVR1C	130399	broad.mit.edu	37	2	158412698	158412698	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:158412698C>T	uc002tzk.3	-	3	694	c.451G>A	c.(451-453)GTG>ATG	p.V151M	ACVR1C_uc002tzl.3_Intron|ACVR1C_uc010fof.2_Intron|ACVR1C_uc010foe.2_Missense_Mutation_p.V101M	NM_145259	NP_660302	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC isoform 1	151	Cytoplasmic (Potential).				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			lung(3)|ovary(2)|skin(2)	7						GGTTCCTCCACATTTGGTCTC	0.478			NA											7	25					0	0	0.00308	0	0
SCN3A	6328	broad.mit.edu	37	2	165947802	165947802	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:165947802G>C	uc002ucx.2	-	28	5353	c.4861C>G	c.(4861-4863)CGA>GGA	p.R1621G	SCN3A_uc010zcy.1_Missense_Mutation_p.R104G|SCN3A_uc002ucy.2_Missense_Mutation_p.R1572G|SCN3A_uc002ucz.2_Missense_Mutation_p.R1572G	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1621	Helical; Voltage-sensor; Name=S4 of repeat IV; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.R1621*(1)		ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CGGATCACTCGGAACAAGGTA	0.448			NA											26	95					0	0	0.001786	0	0
CHRNA1	1134	broad.mit.edu	37	2	175614782	175614782	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:175614782C>G	uc002ujd.2	-	8	1047	c.969G>C	c.(967-969)ATG>ATC	p.M323I	uc002uiw.2_Intron|CHRNA1_uc002uje.2_Missense_Mutation_p.M298I	NM_001039523	NP_001034612	P02708	ACHA_HUMAN	nicotinic cholinergic receptor alpha 1 isoform a	323	Helical.				muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(2)|central_nervous_system(1)|skin(1)	4						TGGTGAACAGCATGTATTTTC	0.517			NA											14	94					0	0	0.003163	0	0
HOXD13	3239	broad.mit.edu	37	2	176957919	176957919	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:176957919G>C	uc002ukf.1	+	1	388	c.301G>C	c.(301-303)GCT>CCT	p.A101P		NM_000523	NP_000514	P35453	HXD13_HUMAN	homeobox D13	101					skeletal system development|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0526)|READ - Rectum adenocarcinoma(9;0.0678)		GCGCCCGGAGGCTCCCCCAGC	0.672			NA	T	NUP98	AML*								9	17					0	0	0.001855	0	0
HNRNPA3	220988	broad.mit.edu	37	2	178081586	178081586	+	Splice_Site	SNP	A	A	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:178081586A>T	uc002ulb.1	+	7	846	c.740_splice	c.e7-2	p.G247_splice	HNRNPA3_uc002ulc.1_Splice_Site_p.G247_splice|HNRNPA3_uc002uld.2_Splice_Site_p.G225_splice|HNRNPA3_uc002ule.2_Splice_Site_p.G24_splice	NM_194247	NP_919223	P51991	ROA3_HUMAN	heterogeneous nuclear ribonucleoprotein A3							catalytic step 2 spliceosome|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding			ovary(2)	2						GTTTTTCCTCAGGAGGCTAtg	0.194			NA											9	31					0	0	0.004482	0	0
ANKRD44	91526	broad.mit.edu	37	2	197863664	197863664	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:197863664T>G	uc002uua.1	-	24	2634	c.2557A>C	c.(2557-2559)ATG>CTG	p.M853L	ANKRD44_uc002utz.3_Missense_Mutation_p.M585L	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	878	ANK 26.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TCAGCAGCCATCATCAGTGCT	0.478			NA											16	40					0	0	0.006122	0	0
FAM126B	285172	broad.mit.edu	37	2	201857028	201857028	+	Silent	SNP	T	T	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:201857028T>A	uc002uws.3	-	10	995	c.807A>T	c.(805-807)CTA>CTT	p.L269L	FAM126B_uc002uwu.2_Silent_p.L187L|FAM126B_uc002uwv.2_Silent_p.L269L	NM_173822	NP_776183	Q8IXS8	F126B_HUMAN	hypothetical protein LOC285172	269						intracellular				ovary(1)	1						AAAAAAGCTCTAGCTGGGCTC	0.338			NA											15	66					0	0	0.004007	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	A	rs121913500		TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:209113112C>A	uc002vcs.2	-	4	641	c.395G>T	c.(394-396)CGT>CTT	p.R132L	IDH1_uc002vct.2_Missense_Mutation_p.R132L|IDH1_uc002vcu.2_Missense_Mutation_p.R132L	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393	Pancreas(158;264 1958 3300 35450 36047)		NA	Mis		gliobastoma 								11	54					1.15088e-07	1.52965e-07	0.004007	1	0
ABCA12	26154	broad.mit.edu	37	2	215851332	215851332	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:215851332A>C	uc002vew.2	-	28	4317	c.4097T>G	c.(4096-4098)CTG>CGG	p.L1366R	ABCA12_uc002vev.2_Missense_Mutation_p.L1048R|ABCA12_uc010zjn.1_Missense_Mutation_p.L293R	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1366	ABC transporter 1.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		ATAAAAGTTCAGATTGAGGTT	0.428	Ovarian(66;664 1488 5121 34295)		NA											7	54					0	0	0.006214	0	0
CXCR2	3579	broad.mit.edu	37	2	218999803	218999803	+	Silent	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:218999803C>A	uc002vgz.1	+	4	504	c.279C>A	c.(277-279)GCC>GCA	p.A93A	CXCR2_uc002vha.1_Silent_p.A93A|CXCR2_uc002vhb.1_Silent_p.A93A	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	93	Helical; Name=2; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						TAGCCTTGGCCGACCTACTCT	0.572			NA											26	107					8.58068e-18	1.40777e-17	0.007291	1	0
COL4A4	1286	broad.mit.edu	37	2	227945211	227945211	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:227945211C>A	uc010zlt.1	-	24	2405	c.1751G>T	c.(1750-1752)GGA>GTA	p.G584V		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	584	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		ACCATGTGATCCTGGCTGCCC	0.473			NA											29	101					0.000339439	0.000396012	0.002096	1	0
KIF1A	547	broad.mit.edu	37	2	241685265	241685265	+	Silent	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:241685265C>A	uc002vzy.2	-	29	3107	c.2961G>T	c.(2959-2961)CTG>CTT	p.L987L	KIF1A_uc010fzk.2_Silent_p.L1088L|KIF1A_uc002vzz.1_Silent_p.L1088L	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	987					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GGGCAGCATCCAGGGGCCCAT	0.622			NA											5	11					1.6384e-10	2.3566e-10	0.001984	1	0
FRG1B	284802	broad.mit.edu	37	20	29628283	29628283	+	Silent	SNP	G	G	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr20:29628283G>C	uc010ztl.1	+	3	227	c.195G>C	c.(193-195)GGG>GGC	p.G65G	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Silent_p.G17G					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						ATGAAGCAGGGGACATAGAAG	0.378			NA											4	73					0	0	0.004482	0	0
C20orf185	359710	broad.mit.edu	37	20	31644416	31644416	+	Silent	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr20:31644416C>A	uc002wym.1	+	2	193	c.193C>A	c.(193-195)CGG>AGG	p.R65R		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	65	Leu-rich.				innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						AGCTGTGAACCGGGGCCTCTT	0.607			NA											18	50					1.01871e-10	1.47878e-10	0.008871	1	0
DHX35	60625	broad.mit.edu	37	20	37597733	37597733	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr20:37597733G>A	uc002xjh.2	+	2	61	c.50G>A	c.(49-51)GGG>GAG	p.G17E	DHX35_uc010zwa.1_5'UTR|DHX35_uc010zwb.1_5'UTR|DHX35_uc010zwc.1_Missense_Mutation_p.G17E	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	17						catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				GGTACAGAGGGGCCAGGTGTA	0.403			NA											4	25					0	0	0.000248	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19698813	19698813	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr21:19698813G>T	uc002ykw.2	-	16	1888	c.1857C>A	c.(1855-1857)AAC>AAA	p.N619K		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	619	Extracellular (Potential).|CUB 2.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						CCAACACATCGTTAGTGATGA	0.448			NA											31	81					1.22384e-17	1.99745e-17	0.002836	1	0
APP	351	broad.mit.edu	37	21	27327992	27327992	+	Silent	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr21:27327992G>A	uc002ylz.2	-	12	1736	c.1536C>T	c.(1534-1536)TTC>TTT	p.F512F	APP_uc011acg.1_Silent_p.F20F|APP_uc010glk.2_Silent_p.F488F|APP_uc002yma.2_Silent_p.F493F|APP_uc011ach.1_Silent_p.F456F|APP_uc002ymb.2_Silent_p.F437F|APP_uc010glj.2_Silent_p.F381F|APP_uc011aci.1_Silent_p.F402F	NM_000484	NP_000475	P05067	A4_HUMAN	amyloid beta A4 protein isoform a precursor	512	Heparin-binding.|Extracellular (Potential).				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)				GCACATGCTCGAAATGCTTTA	0.493			NA											26	40					0	0	0.00632	0	0
KCNJ6	3763	broad.mit.edu	37	21	39086663	39086663	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr21:39086663G>T	uc011aej.1	-	3	850	c.797C>A	c.(796-798)ACG>AAG	p.T266K	KCNJ6_uc002ywo.2_Missense_Mutation_p.T266K	NM_002240	NP_002231	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel J6	266	Cytoplasmic (By similarity).				synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1					Halothane(DB01159)	GTCATCCCCCGTGTAATACCC	0.507	Pancreas(48;379 1118 2936 19024 28214)		NA											29	70					1.06647e-15	1.69666e-15	0.003755	1	0
SERPIND1	3053	broad.mit.edu	37	22	21140420	21140420	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr22:21140420G>T	uc002ztb.1	+	4	1359	c.1292G>T	c.(1291-1293)AGG>ATG	p.R431M	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Missense_Mutation_p.R459M	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	431					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	TCAGACCAAAGGATCGCCATC	0.562			NA											9	111					0.000673444	0.000768605	0.008291	1	0
MYO18B	84700	broad.mit.edu	37	22	26294422	26294422	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr22:26294422A>G	uc003abz.1	+	29	5067	c.4817A>G	c.(4816-4818)CAG>CGG	p.Q1606R	MYO18B_uc003aca.1_Missense_Mutation_p.Q1487R|MYO18B_uc010guy.1_Missense_Mutation_p.Q1488R|MYO18B_uc010guz.1_Missense_Mutation_p.Q1486R|MYO18B_uc011aka.1_Missense_Mutation_p.Q760R|MYO18B_uc011akb.1_Missense_Mutation_p.Q1119R	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1606	Potential.|Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GAGAAGAAGCAGAAGAAGTGA	0.522			NA											8	80					0	0	0.006214	0	0
MCM5	4174	broad.mit.edu	37	22	35817363	35817363	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr22:35817363C>T	uc003anu.3	+	15	1979	c.1885C>T	c.(1885-1887)CAG>TAG	p.Q629*	MCM5_uc010gwr.2_Nonsense_Mutation_p.Q438*|MCM5_uc003anv.3_Nonsense_Mutation_p.Q586*|MCM5_uc003anw.1_Nonsense_Mutation_p.Q413*	NM_006739	NP_006730	P33992	MCM5_HUMAN	minichromosome maintenance complex component 5	629					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)	1						GATGAAGCTGCAGCCCTTCGC	0.622			NA											16	67					0	0	0.00499	0	0
ATP2B2	491	broad.mit.edu	37	3	10381930	10381930	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr3:10381930C>A	uc003bvt.2	-	21	3672	c.3233G>T	c.(3232-3234)GGC>GTC	p.G1078V	ATP2B2_uc003bvv.2_Missense_Mutation_p.G1033V|ATP2B2_uc003bvw.2_Missense_Mutation_p.G1033V|ATP2B2_uc010hdo.2_Missense_Mutation_p.G783V	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	1078	Helical; (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						ACTTACCTGGCCCCAAACGAG	0.572	Ovarian(125;1619 1709 15675 19819 38835)		NA											6	42					1.76689e-08	2.39901e-08	0.006214	1	0
ANKRD28	23243	broad.mit.edu	37	3	15762612	15762612	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr3:15762612C>T	uc003caj.1	-	8	859	c.716G>A	c.(715-717)GGA>GAA	p.G239E	ANKRD28_uc003cai.1_Missense_Mutation_p.G85E|ANKRD28_uc011avz.1_Missense_Mutation_p.G85E|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011awa.1_RNA|ANKRD28_uc003cal.1_Missense_Mutation_p.G269E|ANKRD28_uc003cam.2_Missense_Mutation_p.G272E	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	239	ANK 7.					nucleoplasm	protein binding			breast(1)	1						AGGTGTATTTCCATAGGCATT	0.338			NA											17	195					0	0	0.007413	0	0
CYP8B1	1582	broad.mit.edu	37	3	42917206	42917206	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr3:42917206G>T	uc003cmh.2	-	1	428	c.103C>A	c.(103-105)CTG>ATG	p.L35M	CCBP2_uc003cmd.1_Intron|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Missense_Mutation_p.L35M	NM_004391	NP_004382	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B,	35					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		CCCTTGTCCAGAGGGGGCTCC	0.582			NA											8	38					1.12685e-05	1.40856e-05	0.004482	1	0
SEMA3B	7869	broad.mit.edu	37	3	50313211	50313211	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr3:50313211C>T	uc003cyu.2	+	18	2023	c.1781C>T	c.(1780-1782)CCC>CTC	p.P594L	SEMA3B_uc003cyt.2_Missense_Mutation_p.P593L|SEMA3B_uc003cyv.2_Missense_Mutation_p.P481L|SEMA3B_uc003cyw.2_Missense_Mutation_p.P317L|SEMA3B_uc010hli.2_Missense_Mutation_p.P486L|SEMA3B_uc003cyx.2_Missense_Mutation_p.P480L|SEMA3B_uc003cyy.2_Missense_Mutation_p.P251L|SEMA3B_uc011bdo.1_Missense_Mutation_p.P251L	NM_004636	NP_004627	Q13214	SEM3B_HUMAN	semaphorin 3B isoform 1 precursor	594	Ig-like C2-type.				axon guidance|cell-cell signaling	endoplasmic reticulum|extracellular region|membrane	receptor activity			lung(2)|central_nervous_system(2)|kidney(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		GAGTGTGAGCCCCGCTCGCTG	0.657			NA											4	23					0	0	0.001168	0	0
EAF2	55840	broad.mit.edu	37	3	121591442	121591442	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr3:121591442T>A	uc003een.2	+	5	642	c.543T>A	c.(541-543)GAT>GAA	p.D181E	EAF2_uc003eeo.2_Missense_Mutation_p.D51E	NM_018456	NP_060926	Q96CJ1	EAF2_HUMAN	ELL associated factor 2	181	Ser-rich.|Necessary for transactivation activity.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	protein binding				0				GBM - Glioblastoma multiforme(114;0.0972)		GTTCATCAGATTCCAAAAGTT	0.358	Esophageal Squamous(194;1942 2097 24663 29345 31866)		NA											21	106					0	0	0.004656	0	0
ALG1L	200810	broad.mit.edu	37	3	125652457	125652457	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr3:125652457C>T	uc003eig.1	-	2	225	c.61G>A	c.(61-63)GAG>AAG	p.E21K		NM_001015050	NP_001015050	Q6GMV1	ALG1L_HUMAN	asparagine-linked glycosylation 1-like	21							transferase activity, transferring glycosyl groups				0						GCTGGCCACTCGCGGAGATGC	0.622			NA											4	25					0	0	0.000602	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125854472	125854472	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr3:125854472C>A	uc003eim.1	-	12	1568	c.1378G>T	c.(1378-1380)GAC>TAC	p.D460Y	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Missense_Mutation_p.D359Y|ALDH1L1_uc003eio.2_Missense_Mutation_p.D162Y|ALDH1L1_uc010hsf.1_Missense_Mutation_p.D486Y	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	460	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	TTGTCGACGTCGGTGACTTGG	0.597			NA											6	50					0.00198382	0.00223979	0.001984	1	0
PLSCR4	57088	broad.mit.edu	37	3	145938688	145938688	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr3:145938688T>A	uc010huy.2	-	3	361	c.32A>T	c.(31-33)CAG>CTG	p.Q11L	PLSCR4_uc010huz.2_Missense_Mutation_p.Q11L|PLSCR4_uc003evt.3_Missense_Mutation_p.Q11L|PLSCR4_uc010hva.2_Missense_Mutation_p.Q11L|PLSCR4_uc003evu.3_5'UTR	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	11	Cytoplasmic (By similarity).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						ACCTGCAGGCTGTTCAGGGGC	0.403			NA											6	20					0	0	0.001984	0	0
ZIC1	7545	broad.mit.edu	37	3	147128206	147128206	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr3:147128206C>T	uc003ewe.2	+	1	1026	c.307C>T	c.(307-309)CGC>TGC	p.R103C		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	103					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CTTTCTGTTCCGCAACCGGGG	0.697			NA											4	28					0	0	0.000248	0	0
GPR171	29909	broad.mit.edu	37	3	150917131	150917131	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr3:150917131C>G	uc003eyq.3	-	3	283	c.43G>C	c.(43-45)GAG>CAG	p.E15Q	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_013308	NP_037440	O14626	GP171_HUMAN	G protein-coupled receptor 171	15	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTGAATGGCTCCAGATCTTTA	0.348			NA											7	31					0	0	0.00308	0	0
SI	6476	broad.mit.edu	37	3	164754207	164754207	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr3:164754207C>A	uc003fei.2	-	22	2547	c.2485G>T	c.(2485-2487)GAC>TAC	p.D829Y		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	829	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CAGAAAAAGTCTCCTTTGGCT	0.348			NA								HNSCC(35;0.089)			9	38					2.80697e-09	3.94731e-09	0.000978	1	0
WDR49	151790	broad.mit.edu	37	3	167240120	167240120	+	Silent	SNP	T	T	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr3:167240120T>C	uc003fev.1	-	12	2007	c.1701A>G	c.(1699-1701)AAA>AAG	p.K567K	WDR49_uc003feu.1_Silent_p.K392K|WDR49_uc011bpd.1_Silent_p.K532K|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	567										large_intestine(1)|ovary(1)|skin(1)	3						TTGAGTCATCTTTGTTTTTCT	0.199			NA											3	31					0	0	0.000602	0	0
ADIPOQ	9370	broad.mit.edu	37	3	186572221	186572221	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr3:186572221C>T	uc003fra.2	+	3	547	c.463C>T	c.(463-465)CCT>TCT	p.P155S	ADIPOQ_uc010hyy.2_Missense_Mutation_p.P155S	NM_004797	NP_004788	Q15848	ADIPO_HUMAN	adiponectin precursor	155	C1q.				brown fat cell differentiation|cellular response to drug|cellular response to insulin stimulus|detection of oxidative stress|fatty acid beta-oxidation|generation of precursor metabolites and energy|glucose homeostasis|glucose metabolic process|low-density lipoprotein particle clearance|negative regulation of blood pressure|negative regulation of DNA biosynthetic process|negative regulation of ERK1 and ERK2 cascade|negative regulation of eukaryotic cell surface binding|negative regulation of fat cell differentiation|negative regulation of gluconeogenesis|negative regulation of granulocyte differentiation|negative regulation of heterotypic cell-cell adhesion|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of intracellular protein transport|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|negative regulation of macrophage differentiation|negative regulation of MAP kinase activity|negative regulation of phagocytosis|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein autophosphorylation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of synaptic transmission|negative regulation of transcription, DNA-dependent|negative regulation of tumor necrosis factor production|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cAMP-dependent protein kinase activity|positive regulation of cholesterol efflux|positive regulation of fatty acid metabolic process|positive regulation of glucose import|positive regulation of glycogen (starch) synthase activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of metanephric glomerular visceral epithelial cell development|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myeloid cell apoptosis|positive regulation of protein kinase A signaling cascade|positive regulation of renal albumin absorption|protein homooligomerization|protein localization in plasma membrane|response to glucose stimulus|response to tumor necrosis factor	collagen|endoplasmic reticulum|extracellular space	cytokine activity|eukaryotic cell surface binding|hormone activity|protein homodimerization activity			ovary(1)	1	all_cancers(143;1.2e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.47e-19)	GBM - Glioblastoma multiforme(93;0.0776)		CTGCAACATTCCTGGGCTGTA	0.443			NA											8	66					0	0	0.008291	0	0
SLIT2	9353	broad.mit.edu	37	4	20469408	20469408	+	Silent	SNP	A	A	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr4:20469408A>T	uc003gpr.1	+	5	633	c.429A>T	c.(427-429)CCA>CCT	p.P143P	SLIT2_uc003gps.1_Silent_p.P143P	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	143	LRR 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						AGGCAATCCCAAGGAAAGCTT	0.274			NA											5	21					0	0	0.001168	0	0
AASDH	132949	broad.mit.edu	37	4	57215650	57215650	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr4:57215650T>A	uc003hbn.2	-	11	2420	c.2267A>T	c.(2266-2268)CAT>CTT	p.H756L	AASDH_uc010ihb.2_Missense_Mutation_p.H271L|AASDH_uc011caa.1_Missense_Mutation_p.H603L|AASDH_uc003hbo.2_Missense_Mutation_p.H656L|AASDH_uc011cab.1_Missense_Mutation_p.H271L|AASDH_uc010ihc.2_Missense_Mutation_p.H756L|AASDH_uc003hbp.2_Missense_Mutation_p.H756L	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	756					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				CCACCTCACATGTAACTCCAT	0.433			NA											14	81					0	0	0.003163	0	0
EPHA5	2044	broad.mit.edu	37	4	66242723	66242724	+	Missense_Mutation	DNP	GG	GG	CT			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr4:66242723_66242724GG>CT	uc003hcy.2	-	9	2041_2042	c.1848_1849CC>AG	c.(1846-1851)AGCCTA>AGAGTA	p.616_617SL>RV	EPHA5_uc003hcx.2_Missense_Mutation_p.548_549SL>RV|EPHA5_uc003hcz.2_Intron|EPHA5_uc011cah.1_Missense_Mutation_p.617_618SL>RV|EPHA5_uc011cai.1_Intron|EPHA5_uc003hda.2_Missense_Mutation_p.617_618SL>RV	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	616_617	Cytoplasmic (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						AACCATATTAGGCTTGGATGGG	0.47			NA								TSP Lung(17;0.13)			3	23					0	0	0.004672	0	0
ARHGAP24	83478	broad.mit.edu	37	4	86491764	86491764	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr4:86491764G>T	uc003hpk.2	+	2	519	c.70G>T	c.(70-72)GGG>TGG	p.G24W	ARHGAP24_uc003hpi.1_Missense_Mutation_p.G24W|ARHGAP24_uc003hpj.2_Missense_Mutation_p.G24W	NM_001025616	NP_001020787	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24 isoform 1	24	PH.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		CATCAAGTGTGGGTGGCTGAG	0.488			NA											7	44					0.00307968	0.00346464	0.00308	1	0
Unknown	0	broad.mit.edu	37	4	88815044	88815044	+	Silent	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr4:88815044C>A	uc010iko.1	+	4	1671	c.1671C>A	c.(1669-1671)ATC>ATA	p.I557I						SubName: Full=Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a; SubName: Full=cDNA, FLJ92550, Homo sapiens heat shock 90kDa protein 1, beta (HSPCB), mRNA;												NA						ACCACATGATCAAGCTAGGTC	0.527			NA											40	160					1.22674e-20	2.04457e-20	0.00874	1	0
KIAA1109	84162	broad.mit.edu	37	4	123175486	123175486	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr4:123175486C>G	uc003ieh.2	+	36	6104	c.6059C>G	c.(6058-6060)ACA>AGA	p.T2020R	KIAA1109_uc003iel.1_5'Flank|KIAA1109_uc003iek.2_Missense_Mutation_p.T639R	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	2020					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AGATCTCACACACATGCATTT	0.323			NA											8	34					0	0	0.006214	0	0
ADAD1	132612	broad.mit.edu	37	4	123329128	123329128	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr4:123329128G>T	uc003ieo.2	+	8	1022	c.790G>T	c.(790-792)GAT>TAT	p.D264Y	ADAD1_uc003iep.2_Missense_Mutation_p.D264Y|ADAD1_uc003ieq.2_Missense_Mutation_p.D246Y	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	264	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						CATTAAGCCAGATGGAAGAGT	0.378			NA											12	65					9.31168e-06	1.17327e-05	0.001855	1	0
PCDH10	57575	broad.mit.edu	37	4	134073431	134073431	+	Silent	SNP	A	A	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr4:134073431A>G	uc003iha.2	+	1	2962	c.2136A>G	c.(2134-2136)CTA>CTG	p.L712L	PCDH10_uc003igz.2_Silent_p.L712L	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	712	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		AAACCTCGCTAGACCTCACCC	0.542			NA											10	64					0	0	0.001368	0	0
NPY2R	4887	broad.mit.edu	37	4	156135716	156135716	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr4:156135716G>T	uc003ioq.2	+	2	1120	c.625G>T	c.(625-627)GGC>TGC	p.G209C	NPY2R_uc003ior.2_Missense_Mutation_p.G209C	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	209	Extracellular (Potential).			G -> A (in Ref. 4; AAB07760).	cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				AAAGTGGCCTGGCGAGGAGAA	0.488			NA											25	110					2.08457e-15	3.28319e-15	0.002096	1	0
ANP32C	23520	broad.mit.edu	37	4	165118535	165118535	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr4:165118535T>G	uc011cjk.1	-	1	329	c.329A>C	c.(328-330)AAC>ACC	p.N110T	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	110											0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		GCTCTTGAGGTTTTCTAACTG	0.423			NA											18	60					0	0	0.008871	0	0
MED10	84246	broad.mit.edu	37	5	6374488	6374488	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr5:6374488C>A	uc003jdo.2	-	3	301	c.258G>T	c.(256-258)GAG>GAT	p.E86D		NM_032286	NP_115662	Q9BTT4	MED10_HUMAN	mediator complex subunit 10	86					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(1)	1						CTAGAGCCCTCTCCAGGCACT	0.423			NA											60	72					2.84776e-26	4.84888e-26	0.00361	1	0
PRDM9	56979	broad.mit.edu	37	5	23522423	23522423	+	Silent	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr5:23522423G>A	uc003jgo.2	+	7	701	c.519G>A	c.(517-519)AAG>AAA	p.K173K		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	173					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AACTCAGGAAGAAGGAGACTG	0.428			NA								HNSCC(3;0.000094)			39	80					0	0	0.003214	0	0
CDH6	1004	broad.mit.edu	37	5	31267710	31267710	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr5:31267710A>C	uc003jhe.1	+	2	456	c.130A>C	c.(130-132)AGC>CGC	p.S44R	CDH6_uc003jhd.1_Missense_Mutation_p.S44R	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	44					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						CTCTGGAAACAGCAAAAATGA	0.488			NA											29	36					0	0	0.002096	0	0
PAIP1	10605	broad.mit.edu	37	5	43535667	43535667	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr5:43535667C>G	uc003job.2	-	7	1295	c.1048G>C	c.(1048-1050)GAA>CAA	p.E350Q	PAIP1_uc003joa.2_Missense_Mutation_p.E271Q|PAIP1_uc010ivp.2_Missense_Mutation_p.E271Q|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Missense_Mutation_p.E238Q	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	350	MIF4G.				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					ACAACGTTTTCAATTCTCTGA	0.348			NA											11	18					0	0	0.001855	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54649077	54649077	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr5:54649077G>T	uc003jpy.3	+	14	1779	c.1513G>T	c.(1513-1515)GAT>TAT	p.D505Y	SKIV2L2_uc011cqi.1_Missense_Mutation_p.D404Y	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	505	Helicase C-terminal.				maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				CCGCAAATTTGATGGGAAGGA	0.338	Melanoma(2;92 134 23744 29976 33782)		NA											22	42					6.44725e-10	9.1071e-10	0.002299	1	0
IL13	3596	broad.mit.edu	37	5	131995902	131995902	+	Silent	SNP	C	C	A	rs78628956	by1000genomes	TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr5:131995902C>A	uc003kxj.1	+	4	383	c.369C>A	c.(367-369)ATC>ATA	p.I123I		NM_002188	NP_002179	P35225	IL13_HUMAN	interleukin 13 precursor	123					cellular component movement|immune response|inflammatory response|signal transduction	extracellular space|soluble fraction	cytokine activity			ovary(1)|skin(1)	2		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACACCAAAATCGAGGTGGCCC	0.468			NA											3	37					0.004672	0.00518197	0.004672	1	0
SPOCK1	6695	broad.mit.edu	37	5	136324183	136324183	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr5:136324183T>A	uc003lbo.2	-	7	1047	c.856A>T	c.(856-858)AAC>TAC	p.N286Y	SPOCK1_uc003lbp.2_Missense_Mutation_p.N286Y	NM_004598	NP_004589	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains	286					cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCACACGAGTTGAAAAGAGGC	0.498			NA											6	93					0	0	0.001984	0	0
TMCO6	55374	broad.mit.edu	37	5	140023455	140023455	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr5:140023455C>A	uc003lgl.2	+	9	1110	c.1009C>A	c.(1009-1011)CGT>AGT	p.R337S	TMCO6_uc003lgm.2_Missense_Mutation_p.R343S|TMCO6_uc010jft.2_Missense_Mutation_p.R97S|TMCO6_uc003lgn.2_Missense_Mutation_p.R228S|TMCO6_uc003lgo.2_Missense_Mutation_p.R97S	NM_018502	NP_060972	Q96DC7	TMCO6_HUMAN	transmembrane and coiled-coil domains 6	337					protein import into nucleus	cytoplasm|nuclear pore	binding|protein transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGAGATGAGCGTGTTGTGGC	0.537			NA											23	32					1.66031e-10	2.37726e-10	0.003954	1	0
PCDHA8	56140	broad.mit.edu	37	5	140222139	140222139	+	Silent	SNP	C	C	T	rs147149527	byFrequency	TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr5:140222139C>T	uc003lhs.2	+	1	1233	c.1233C>T	c.(1231-1233)AGC>AGT	p.S411S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.S411S	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	411	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCTGGACAGCGCCCTGGACC	0.627			NA											6	216					0	0	0.007291	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140752183	140752183	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr5:140752183C>A	uc003ljw.1	+	1	2222	c.2222C>A	c.(2221-2223)CCC>CAC	p.P741H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.P741H|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	741	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGTTCTCCCCACCTACAGC	0.498			NA											13	40					3.27435e-08	4.38903e-08	0.00245	1	0
GALNT10	55568	broad.mit.edu	37	5	153783767	153783767	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr5:153783767C>G	uc003lvh.2	+	8	1292	c.1160C>G	c.(1159-1161)GCC>GGC	p.A387G	GALNT10_uc010jic.2_RNA|GALNT10_uc010jid.2_Missense_Mutation_p.A228G|uc003lvi.2_Intron|GALNT10_uc003lvj.2_Missense_Mutation_p.A58G	NM_198321	NP_938080	Q86SR1	GLT10_HUMAN	GalNAc transferase 10 isoform a	387	Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			GTCAGCCTGGCCCGGGTAAGG	0.617			NA											9	7					0	0	0.006214	0	0
SLIT3	6586	broad.mit.edu	37	5	168233578	168233578	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr5:168233578G>T	uc003mab.2	-	9	1228	c.808C>A	c.(808-810)CCC>ACC	p.P270T	SLIT3_uc010jjg.2_Missense_Mutation_p.P270T|SLIT3_uc010jji.2_Missense_Mutation_p.P270T|SLIT3_uc003mac.1_Missense_Mutation_p.P67T	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	270					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGGATGGGGGCTCCGAGTGG	0.572	Ovarian(29;311 847 10864 17279 24903)		NA											6	75					0.000157383	0.000184984	0.00308	1	0
RIPK1	8737	broad.mit.edu	37	6	3083425	3083425	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr6:3083425C>T	uc010jni.2	+	5	798	c.566C>T	c.(565-567)ACC>ATC	p.T189I	RIPK1_uc003muv.3_Missense_Mutation_p.T26I|RIPK1_uc003muw.3_Missense_Mutation_p.T124I|RIPK1_uc011dhs.1_Missense_Mutation_p.T143I|RIPK1_uc003mux.2_Missense_Mutation_p.T189I	NM_003804	NP_003795	Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine	189	Protein kinase.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			large_intestine(3)|lung(1)|skin(1)	5	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				AATGGCGGCACCCTCTACTAC	0.522			NA											10	56					0	0	0.008291	0	0
PRPF4B	8899	broad.mit.edu	37	6	4037669	4037669	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr6:4037669G>C	uc003mvv.2	+	3	1368	c.1277G>C	c.(1276-1278)AGA>ACA	p.R426T	PRPF4B_uc003mvw.2_RNA|PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	426	Arg/Lys-rich (basic).					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				AGACGTGAAAGATCAAAAGAT	0.408			NA											3	48					0	0	0.001984	0	0
PGBD1	84547	broad.mit.edu	37	6	28269741	28269741	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr6:28269741A>T	uc003nky.2	+	7	2480	c.2110A>T	c.(2110-2112)ATA>TTA	p.I704L	PGBD1_uc003nkz.2_Missense_Mutation_p.I704L	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	704					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						TGCTGTGGGCATAGAACCAGT	0.403			NA											19	132					0	0	0.002299	0	0
EHMT2	10919	broad.mit.edu	37	6	31848493	31848493	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr6:31848493C>T	uc003nxz.1	-	27	3419	c.3409G>A	c.(3409-3411)GCC>ACC	p.A1137T	EHMT2_uc003nxv.1_Missense_Mutation_p.A176T|EHMT2_uc003nxw.1_Missense_Mutation_p.A176T|EHMT2_uc003nxx.1_Missense_Mutation_p.A335T|EHMT2_uc003nxy.1_Missense_Mutation_p.A935T|EHMT2_uc011don.1_Missense_Mutation_p.A1160T|EHMT2_uc003nya.1_Missense_Mutation_p.A1103T|SLC44A4_uc010jti.2_5'Flank|SLC44A4_uc011dom.1_5'Flank	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	1137	SET.				DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						CTGAAGAAGGCGATGCGTGGA	0.582			NA											4	56					0	0	0.000602	0	0
C6orf106	64771	broad.mit.edu	37	6	34614502	34614502	+	Silent	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr6:34614502C>G	uc003ojr.2	-	3	632	c.387G>C	c.(385-387)GTG>GTC	p.V129V	C6orf106_uc003ojs.2_Intron	NM_024294	NP_077270	Q9H6K1	CF106_HUMAN	chromosome 6 open reading frame 106 isoform a	129										skin(2)|ovary(1)	3						ATCTCACCATCACCATGTTCA	0.517			NA											38	156					0	0	0.002222	0	0
FBXL4	26235	broad.mit.edu	37	6	99374724	99374724	+	Silent	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr6:99374724G>A	uc003ppf.1	-	3	499	c.141C>T	c.(139-141)CTC>CTT	p.L47L	FBXL4_uc003ppg.1_Silent_p.L47L|FBXL4_uc003pph.1_5'UTR	NM_012160	NP_036292	Q9UKA2	FBXL4_HUMAN	F-box and leucine-rich repeat protein 4	47					ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex				skin(2)	2		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0413)		CCTCTGCATTGAGAGGGGAAG	0.438			NA											27	99					0	0	0.002096	0	0
SYNE1	23345	broad.mit.edu	37	6	152685991	152685991	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr6:152685991C>A	uc010kiw.2	-	63	10738	c.10136G>T	c.(10135-10137)CGT>CTT	p.R3379L	SYNE1_uc003qot.3_Missense_Mutation_p.R3386L|SYNE1_uc003qou.3_Missense_Mutation_p.R3379L|SYNE1_uc010kja.1_Missense_Mutation_p.R84L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3379	Spectrin 7.|HAT 6.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCTTTTACAACGAATCCCTGC	0.448			NA								HNSCC(10;0.0054)			12	32					0.00010058	0.000120466	0.001368	1	0
C6orf118	168090	broad.mit.edu	37	6	165715076	165715076	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr6:165715076G>T	uc003qum.3	-	2	771	c.735C>A	c.(733-735)CAC>CAA	p.H245Q	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	245											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		GCTTTCTCTCGTGGCCCGCGG	0.602			NA											10	49					6.40141e-05	7.7855e-05	0.000978	1	0
CARD11	84433	broad.mit.edu	37	7	2985479	2985479	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr7:2985479G>T	uc003smv.2	-	4	736	c.332C>A	c.(331-333)CCC>CAC	p.P111H		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	111					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TCTCCGAGTGGGCTCTTTCCC	0.423			NA	Mis		DLBCL								27	170					3.1745e-13	4.85421e-13	0.008361	1	0
CCDC129	223075	broad.mit.edu	37	7	31682641	31682641	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr7:31682641G>T	uc003tcj.1	+	11	2650	c.1657G>T	c.(1657-1659)GTC>TTC	p.V553F	CCDC129_uc011kad.1_Missense_Mutation_p.V563F|CCDC129_uc003tci.1_Missense_Mutation_p.V404F|CCDC129_uc011kae.1_Missense_Mutation_p.V579F|CCDC129_uc003tck.1_Missense_Mutation_p.V461F	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	553											0						TGAGTATGAGGTCACCAGACC	0.547			NA											32	118					4.62619e-21	7.79278e-21	0.004289	1	0
SEMA3A	10371	broad.mit.edu	37	7	83739879	83739879	+	Silent	SNP	T	T	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr7:83739879T>A	uc003uhz.2	-	4	675	c.360A>T	c.(358-360)GTA>GTT	p.V120V		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	120	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						ATGCCTTAAGTACCTTGATGA	0.428			NA											13	58					0	0	0.004007	0	0
DLX6	1750	broad.mit.edu	37	7	96639143	96639143	+	Silent	SNP	T	T	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr7:96639143T>C	uc003uom.2	+	4	582	c.582T>C	c.(580-582)TTT>TTC	p.F194F	DLX6AS_uc003uol.2_Intron|DLX6AS_uc010lfo.1_Intron	NM_005222	NP_005213	P56179	DLX6_HUMAN	distal-less homeobox 6	104	Homeobox.				nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					GCTCTAAGTTTAAGAAACTGC	0.542			NA											8	43					0	0	0.004482	0	0
SRRT	51593	broad.mit.edu	37	7	100481745	100481745	+	Silent	SNP	G	G	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr7:100481745G>C	uc003uwy.2	+	7	910	c.642G>C	c.(640-642)CGG>CGC	p.R214R	SRRT_uc010lhl.1_Silent_p.R214R|SRRT_uc003uxa.2_Silent_p.R214R|SRRT_uc003uwz.2_Silent_p.R214R	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	214					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						AGGAGGCCCGGGGGGCCCTGC	0.557			NA											11	49					0	0	0.001368	0	0
GCC1	79571	broad.mit.edu	37	7	127222755	127222755	+	Silent	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr7:127222755C>T	uc003vma.2	-	2	2059	c.1641G>A	c.(1639-1641)CAG>CAA	p.Q547Q		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	547	Potential.					Golgi membrane|plasma membrane	protein binding			ovary(2)	2						CATCAGCCTCCTGCTGGTGTT	0.622			NA											9	54					0	0	0.008291	0	0
C7orf45	136263	broad.mit.edu	37	7	129855958	129855958	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr7:129855958G>T	uc003vpp.2	+	3	430	c.383G>T	c.(382-384)CGA>CTA	p.R128L		NM_145268	NP_660311	Q8WWF3	CG045_HUMAN	hypothetical protein LOC136263	128						integral to membrane					0	Melanoma(18;0.0435)					GAACAAAGACGAGCCAGGCGC	0.483			NA											6	31					5.18039e-06	6.55351e-06	0.00308	1	0
PLXNA4	91584	broad.mit.edu	37	7	131887528	131887528	+	Silent	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr7:131887528G>A	uc003vra.3	-	12	2692	c.2463C>T	c.(2461-2463)TTC>TTT	p.F821F		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	821	PSI 3.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						AGCCACATGCGAAGTCTGGGT	0.637			NA											6	17					0	0	0.001168	0	0
TRY6	154754	broad.mit.edu	37	7	142480037	142480037	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr7:142480037T>A	uc011ksq.1	+	2	252	c.169T>A	c.(169-171)TGG>AGG	p.W57R	uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_RNA|uc003wan.1_Intron|TRY6_uc011kso.1_RNA|TRY6_uc011ksr.1_RNA	NR_001296				SubName: Full=Protease, serine, 3; Flags: Fragment;												0						CAGCGAACAGTGGGTGGTGTC	0.587			NA											14	77					0	0	0.00499	0	0
Unknown	0	broad.mit.edu	37	7	142510289	142510289	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr7:142510289T>C	uc003wbp.2	-	2	429	c.317A>G	c.(316-318)TAT>TGT	p.Y106C						SubName: Full=V_segment translation product; Flags: Fragment;												NA						GGCACAGAGATAGAAGCCAGA	0.567			NA											3	19					0	0	0.001984	0	0
RHOBTB2	23221	broad.mit.edu	37	8	22865579	22865579	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr8:22865579G>A	uc003xcq.2	+	6	2112	c.1575G>A	c.(1573-1575)ATG>ATA	p.M525I	RHOBTB2_uc003xcp.2_Missense_Mutation_p.M547I|RHOBTB2_uc011kzp.1_Missense_Mutation_p.M532I|uc003xcr.2_RNA	NM_015178	NP_055993	Q9BYZ6	RHBT2_HUMAN	Rho-related BTB domain containing 2 isoform 3	525	BTB 2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			ovary(1)|lung(1)	2		Prostate(55;0.0513)|Breast(100;0.214)		Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		GTGACTGGATGGCTGCCATGT	0.557			NA											8	53					0	0	0.00308	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70744391	70744391	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr8:70744391C>A	uc003xyl.2	-	2	1225	c.518G>T	c.(517-519)TGC>TTC	p.C173F	SLCO5A1_uc010lzb.2_Missense_Mutation_p.C173F|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Missense_Mutation_p.C173F|SLCO5A1_uc010lzc.2_Missense_Mutation_p.C173F	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	173	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			GATGTCAAAGCAGCTGACCAG	0.612			NA											8	41					1.12685e-05	1.40856e-05	0.004482	1	0
TRPA1	8989	broad.mit.edu	37	8	72975766	72975766	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr8:72975766C>G	uc003xza.2	-	5	768	c.593G>C	c.(592-594)GGA>GCA	p.G198A		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	198	ANK 5.|Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	AGGGAAACATCCCCATTTATT	0.363			NA											15	34					0	0	0.008871	0	0
ZFHX4	79776	broad.mit.edu	37	8	77761908	77761908	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr8:77761908A>G	uc003yav.2	+	8	4058	c.3671A>G	c.(3670-3672)CAC>CGC	p.H1224R	ZFHX4_uc003yau.1_Missense_Mutation_p.H1269R|ZFHX4_uc003yaw.1_Missense_Mutation_p.H1224R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1224	C2H2-type 9.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACGCATTTGCACAGTGTGTCT	0.463			NA								HNSCC(33;0.089)			6	27					0	0	0.00308	0	0
ZFAND1	79752	broad.mit.edu	37	8	82626195	82626195	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr8:82626195C>T	uc003ycj.1	-	6	452	c.438G>A	c.(436-438)ATG>ATA	p.M146I	ZFAND1_uc010lzx.1_Missense_Mutation_p.M146I|ZFAND1_uc003yck.1_Missense_Mutation_p.M39I	NM_024699	NP_078975	Q8TCF1	ZFAN1_HUMAN	zinc finger, AN1-type domain 1	146							zinc ion binding			ovary(1)	1						TCTTTAATTTCATCAATGCAA	0.308			NA											3	51					0	0	0.000248	0	0
GLDC	2731	broad.mit.edu	37	9	6587243	6587243	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr9:6587243A>C	uc003zkc.2	-	15	1941	c.1748T>G	c.(1747-1749)GTG>GGG	p.V583G		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	583					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	ATCCAGAGGCACAAAGGGGTG	0.363			NA											11	53					0	0	0.00245	0	0
KIAA1797	54914	broad.mit.edu	37	9	20929593	20929593	+	Silent	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr9:20929593C>G	uc003zog.1	+	29	3678	c.3315C>G	c.(3313-3315)CTC>CTG	p.L1105L	KIAA1797_uc003zoh.1_Silent_p.L541L	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	1105						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		AAGAGAAACTCAGGTACAGTT	0.403			NA											5	51					0	0	0.001984	0	0
SMU1	55234	broad.mit.edu	37	9	33053211	33053211	+	Silent	SNP	G	G	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr9:33053211G>C	uc003zsf.1	-	10	1308	c.1200C>G	c.(1198-1200)GTC>GTG	p.V400V	SMU1_uc010mjo.1_Silent_p.V400V|SMU1_uc010mjp.1_Intron|SMU1_uc011lnu.1_Silent_p.V239V	NM_018225	NP_060695	Q2TAY7	SMU1_HUMAN	smu-1 suppressor of mec-8 and unc-52 homolog	400	WD 5.					cytoplasm|nucleus				ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.11)		TCACACTGTTGACGGTAATAT	0.443			NA											14	70					0	0	0.00245	0	0
FRMPD1	22844	broad.mit.edu	37	9	37735585	37735585	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr9:37735585G>A	uc004aag.1	+	13	1299	c.1255G>A	c.(1255-1257)GGA>AGA	p.G419R	FRMPD1_uc004aah.1_Missense_Mutation_p.G419R|FRMPD1_uc011lqm.1_Missense_Mutation_p.G241R|FRMPD1_uc011lqn.1_Missense_Mutation_p.G288R	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	419	FERM.					cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		CCTTCTAGTTGGAGCCAAGTA	0.443			NA											12	65					0	0	0.00245	0	0
TLE1	7088	broad.mit.edu	37	9	84208062	84208062	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr9:84208062C>T	uc004aly.2	-	15	1900	c.1459G>A	c.(1459-1461)GTG>ATG	p.V487M	TLE1_uc004alz.2_Missense_Mutation_p.V497M|TLE1_uc011lsr.1_Missense_Mutation_p.V472M|TLE1_uc004ama.1_Missense_Mutation_p.V486M	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	487	WD 1.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						ACAGCGCACACCACCTCCCCG	0.637	NSCLC(155;1437 1995 30668 39354 45875)|Melanoma(16;266 781 14000 47728 51870)		NA											44	129					0	0	0.00361	0	0
C9orf79	286234	broad.mit.edu	37	9	90501513	90501513	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr9:90501513A>G	uc004app.3	+	4	2146	c.2111A>G	c.(2110-2112)GAC>GGC	p.D704G	C9orf79_uc004apo.1_Missense_Mutation_p.D516G	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	704						integral to membrane				ovary(3)	3						AGGTTCTCTGACAAGGGGTGC	0.597			NA											19	44					0	0	0.001882	0	0
SPTAN1	6709	broad.mit.edu	37	9	131390214	131390214	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr9:131390214C>G	uc004bvl.3	+	50	6798	c.6685C>G	c.(6685-6687)CTC>GTC	p.L2229V	SPTAN1_uc004bvm.3_Missense_Mutation_p.L2234V|SPTAN1_uc004bvn.3_Missense_Mutation_p.L2209V|SPTAN1_uc010mye.1_3'UTR|SPTAN1_uc010myf.1_Missense_Mutation_p.L58V|SPTAN1_uc004bvo.3_5'Flank	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2229	Spectrin 23.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GACATACCTCCTCGATGGGTT	0.567	NSCLC(120;833 1744 2558 35612 37579)		NA											37	453					0	0	0.00623	0	0
ZDHHC12	84885	broad.mit.edu	37	9	131484063	131484063	+	Missense_Mutation	SNP	G	G	T	rs113339803		TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr9:131484063G>T	uc004bvy.2	-	4	385	c.349C>A	c.(349-351)CGC>AGC	p.R117S	ZDHHC12_uc004bvz.2_Missense_Mutation_p.R172S	NM_032799	NP_116188	Q96GR4	ZDH12_HUMAN	zinc finger, DHHC domain containing 12	117	DHHC-type.					integral to membrane	acyltransferase activity|zinc ion binding				0						ACGCAACGGCGGCACTCACGG	0.662			NA											19	75					2.27731e-05	2.79125e-05	0.001882	1	0
BAT2L1	84726	broad.mit.edu	37	9	134308112	134308112	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr9:134308112C>G	uc004can.3	+	2	279	c.224C>G	c.(223-225)CCC>CGC	p.P75R	BAT2L1_uc004cam.1_Missense_Mutation_p.P75R	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	75							protein binding				0						GGAAACGACCCCAACATCGTG	0.557			NA											4	56					0	0	0.000248	0	0
KCNT1	57582	broad.mit.edu	37	9	138651666	138651666	+	Silent	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr9:138651666C>G	uc011mdq.1	+	11	1070	c.996C>G	c.(994-996)GTC>GTG	p.V332V	KCNT1_uc011mdr.1_Silent_p.V159V|KCNT1_uc010nbf.2_Silent_p.V287V|KCNT1_uc004cgo.1_Silent_p.V81V	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	332						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		TGCTGGTGGTCATCATGATCT	0.632			NA											5	27					0	0	0.001984	0	0
ARSH	347527	broad.mit.edu	37	X	2947329	2947329	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:2947329G>T	uc011mhj.1	+	8	1241	c.1241G>T	c.(1240-1242)AGG>ATG	p.R414M		NM_001011719	NP_001011719	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	414						integral to membrane	arylsulfatase activity|metal ion binding			lung(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CTGGAAGGAAGGGCGTCCCAC	0.547			NA											15	96					1.02788e-11	1.51301e-11	0.00499	1	0
ATXN3L	92552	broad.mit.edu	37	X	13337344	13337344	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:13337344C>A	uc010ned.2	-	1	1175	c.710G>T	c.(709-711)CGC>CTC	p.R237L		NM_001135995	NP_001129467	Q9H3M9	ATX3L_HUMAN	ataxin 3-like	237	UIM 1.				protein deubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ubiquitin-specific protease activity	p.R237H(1)		lung(2)|ovary(2)|large_intestine(1)|skin(1)	6						GGTTTCTTGGCGGCTTAGTTC	0.423			NA											37	208					1.59361e-14	2.48508e-14	0.006999	1	0
RAI2	10742	broad.mit.edu	37	X	17818601	17818601	+	Silent	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:17818601G>T	uc004cyf.2	-	3	2100	c.1530C>A	c.(1528-1530)TCC>TCA	p.S510S	RAI2_uc004cyg.2_Silent_p.S510S|RAI2_uc010nfa.2_Silent_p.S510S|RAI2_uc004cyh.3_Silent_p.S510S|RAI2_uc011miy.1_Silent_p.S460S	NM_021785	NP_068557	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	510					embryo development					ovary(1)|breast(1)	2	Hepatocellular(33;0.183)					GTATTTCCTGGGAGTTCACTT	0.403			NA											54	277					1.07796e-43	1.84541e-43	0.00361	1	0
PDHA1	5160	broad.mit.edu	37	X	19377734	19377734	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:19377734G>T	uc004czg.3	+	11	1281	c.1136G>T	c.(1135-1137)GGT>GTT	p.G379V	PDHA1_uc004czh.3_Missense_Mutation_p.G414V|PDHA1_uc011mjc.1_Missense_Mutation_p.G383V|PDHA1_uc011mjd.1_Missense_Mutation_p.G345V|PDHA1_uc010nfk.2_Missense_Mutation_p.G317V|PDHA1_uc010nfl.2_Missense_Mutation_p.G170V	NM_000284	NP_000275	P08559	ODPA_HUMAN	pyruvate dehydrogenase E1 alpha 1 precursor	379					glycolysis|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	protein binding|pyruvate dehydrogenase (acetyl-transferring) activity			ovary(1)	1	Hepatocellular(33;0.183)				NADH(DB00157)	GAAGTTCGTGGTGCCAATCAG	0.512			NA											10	61					1.5842e-08	2.1887e-08	0.001855	1	0
PHEX	5251	broad.mit.edu	37	X	22244559	22244559	+	Splice_Site	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:22244559G>A	uc004dah.2	+	19	2103	c.1900_splice	c.e19-1	p.V634_splice	PHEX_uc011mjr.1_Splice_Site_p.V634_splice|PHEX_uc011mjs.1_Splice_Site_p.V537_splice	NM_000444	NP_000435	P78562	PHEX_HUMAN	phosphate-regulating neutral endopeptidase						biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3						CTTTCTGTTAGGTCAAGGGGA	0.393			NA											9	66					0	0	0.004482	0	0
MAGEB4	4115	broad.mit.edu	37	X	30260717	30260717	+	Silent	SNP	T	T	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:30260717T>A	uc004dcb.2	+	1	549	c.465T>A	c.(463-465)TCT>TCA	p.S155S	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	155	MAGE.									ovary(1)	1						GGAAAGTCTCTCAGCGCACGG	0.498			NA											7	23					0	0	0.001984	0	0
FAM47C	442444	broad.mit.edu	37	X	37026574	37026574	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:37026574G>A	uc004ddl.1	+	1	105	c.91G>A	c.(91-93)GCG>ACG	p.A31T		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	31										ovary(3)	3						CAAGTACTTCGCGAAGCGCAA	0.642			NA											5	23					0	0	0.000602	0	0
FAM47C	442444	broad.mit.edu	37	X	37027156	37027156	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:37027156C>G	uc004ddl.1	+	1	687	c.673C>G	c.(673-675)CAG>GAG	p.Q225E		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	225										ovary(3)	3						TCTCCGCCCACAGCCTCCCAA	0.647			NA											6	62					0	0	0.001168	0	0
USP9X	8239	broad.mit.edu	37	X	41089775	41089775	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:41089775C>A	uc004dfb.2	+	44	8134	c.7501C>A	c.(7501-7503)CCA>ACA	p.P2501T	USP9X_uc004dfc.2_Missense_Mutation_p.P2485T	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	2501					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						CCAAGATGCTCCAGATGAACA	0.373	Ovarian(172;1807 2695 35459 49286)		NA											10	62					1.11149e-13	1.71627e-13	0.008291	1	0
WDR13	64743	broad.mit.edu	37	X	48457261	48457261	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:48457261C>A	uc004dkh.1	+	3	345	c.198C>A	c.(196-198)TAC>TAA	p.Y66*	WDR13_uc010nif.1_Intron|WDR13_uc004dki.1_5'UTR|WDR13_uc004dkj.1_Nonsense_Mutation_p.Y66*|WDR13_uc004dkk.1_5'UTR|WDR13_uc004dkl.3_5'UTR|WDR13_uc011mme.1_5'Flank	NM_017883	NP_060353	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13 protein	66						cytoplasm|nucleus				ovary(2)	2						GCCAGCGCTACGGGCCCCTCT	0.677			NA											7	28					0.000157383	0.000184984	0.00308	1	0
WDR13	64743	broad.mit.edu	37	X	48460174	48460174	+	Silent	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:48460174G>T	uc004dkh.1	+	7	981	c.834G>T	c.(832-834)GTG>GTT	p.V278V	WDR13_uc010nif.1_Silent_p.V156V|WDR13_uc004dki.1_Silent_p.V186V|WDR13_uc004dkj.1_Silent_p.V278V|WDR13_uc004dkk.1_Silent_p.V186V|WDR13_uc004dkl.3_Silent_p.V186V	NM_017883	NP_060353	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13 protein	278						cytoplasm|nucleus				ovary(2)	2						CCCCACAGGTGGGGAACGCCA	0.587			NA											7	24					2.52707e-12	3.77264e-12	0.006214	1	0
AKAP4	8852	broad.mit.edu	37	X	49955642	49955642	+	Silent	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:49955642G>T	uc004dow.1	-	6	2650	c.2526C>A	c.(2524-2526)GCC>GCA	p.A842A	AKAP4_uc004dov.1_Silent_p.A459A|AKAP4_uc010njp.1_Silent_p.A664A|AKAP4_uc004dou.1_Silent_p.A833A	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	842					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					ACTGTTTCCTGGCCACCTTTC	0.532			NA											22	44					3.62473e-10	5.1432e-10	0.001882	1	0
DGKK	139189	broad.mit.edu	37	X	50213148	50213148	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:50213148G>T	uc010njr.1	-	1	590	c.530C>A	c.(529-531)CCA>CAA	p.P177Q		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	177	33 X 4 AA approximate tandem repeats of E-P-A-P.|33.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					ACATGGTGCTGGACTTGGACG	0.383			NA											4	21					0.000602214	0.000694863	0.000602	1	0
ITIH5L	347365	broad.mit.edu	37	X	54814955	54814955	+	Silent	SNP	A	A	G			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:54814955A>G	uc004dtj.2	-	5	774	c.744T>C	c.(742-744)GTT>GTC	p.V248V		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	248					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						CATCGTACTGAACCAGGAAGT	0.582			NA											9	50					0	0	0.006214	0	0
ATRX	546	broad.mit.edu	37	X	76938069	76938069	+	Silent	SNP	G	G	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:76938069G>C	uc004ecp.3	-	9	2911	c.2679C>G	c.(2677-2679)GGC>GGG	p.G893G	ATRX_uc004ecq.3_Silent_p.G855G|ATRX_uc004eco.3_Silent_p.G678G|ATRX_uc004ecr.2_Silent_p.G825G|ATRX_uc010nlx.1_Silent_p.G864G|ATRX_uc010nly.1_Silent_p.G838G	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	893					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TATCAACTGTGCCTTCTGCTG	0.423			NA	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						38	173					0	0	0.003214	0	0
ATP7A	538	broad.mit.edu	37	X	77244097	77244097	+	Silent	SNP	T	T	C			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:77244097T>C	uc004ecx.3	+	3	640	c.480T>C	c.(478-480)TGT>TGC	p.C160C	ATP7A_uc004ecw.2_Silent_p.C160C	NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	160	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						CAGGAGCTTGTGAAGATCATA	0.418			NA											17	99					0	0	0.008871	0	0
BRWD3	254065	broad.mit.edu	37	X	79951432	79951433	+	Missense_Mutation	DNP	TT	TT	AA			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	TT	TT	-	-	TT	TT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:79951432_79951433TT>AA	uc004edt.2	-	27	3388_3389	c.3125_3126AA>TT	c.(3124-3126)GAA>GTT	p.E1042V	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.E638V|BRWD3_uc004edp.2_Missense_Mutation_p.E871V|BRWD3_uc004edq.2_Missense_Mutation_p.E638V|BRWD3_uc010nmj.1_Missense_Mutation_p.E638V|BRWD3_uc004edr.2_Missense_Mutation_p.E712V|BRWD3_uc004eds.2_Missense_Mutation_p.E638V|BRWD3_uc004edu.2_Missense_Mutation_p.E712V|BRWD3_uc004edv.2_Missense_Mutation_p.E638V|BRWD3_uc004edw.2_Missense_Mutation_p.E638V|BRWD3_uc004edx.2_Missense_Mutation_p.E638V|BRWD3_uc004edy.2_Missense_Mutation_p.E638V|BRWD3_uc004edz.2_Missense_Mutation_p.E712V|BRWD3_uc004eea.2_Missense_Mutation_p.E712V|BRWD3_uc004eeb.2_Missense_Mutation_p.E638V	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1042										ovary(4)	4						TTTCTTTGGCTTCATTATAAAA	0.302			NA											8	26					0	0	0.004672	0	0
KLHL4	56062	broad.mit.edu	37	X	86868949	86868949	+	Missense_Mutation	SNP	C	C	A	rs146051966	byFrequency	TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:86868949C>A	uc004efb.2	+	2	674	c.492C>A	c.(490-492)CAC>CAA	p.H164Q	KLHL4_uc004efa.2_Missense_Mutation_p.H164Q	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	164						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						TTATAAACCACGCAGAGCAAA	0.423			NA											15	64					0.000308642	0.000361421	0.003163	1	0
ARMCX2	9823	broad.mit.edu	37	X	100911668	100911668	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:100911668C>A	uc004eid.2	-	3	1262	c.907G>T	c.(907-909)GAA>TAA	p.E303*	ARMCX2_uc004eie.3_Nonsense_Mutation_p.E303*|ARMCX2_uc004eif.3_Nonsense_Mutation_p.E303*|ARMCX2_uc004eig.3_Nonsense_Mutation_p.E303*|ARMCX2_uc010nnt.2_Nonsense_Mutation_p.E303*	NM_177949	NP_808818	Q7L311	ARMX2_HUMAN	ALEX2 protein	303						integral to membrane	binding			ovary(6)	6						TCGTCTACTTCAACTTTGCTT	0.597			NA											24	100					9.22233e-05	0.000110879	0.004656	1	0
BHLHB9	80823	broad.mit.edu	37	X	102005252	102005252	+	Silent	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:102005252C>A	uc010nog.2	+	4	1900	c.1329C>A	c.(1327-1329)GCC>GCA	p.A443A	BHLHB9_uc011mrq.1_Silent_p.A443A|BHLHB9_uc011mrr.1_Silent_p.A443A|BHLHB9_uc011mrs.1_Silent_p.A443A|BHLHB9_uc011mrt.1_Silent_p.A443A|BHLHB9_uc004ejo.2_Silent_p.A443A|BHLHB9_uc011mru.1_Silent_p.A443A|BHLHB9_uc011mrv.1_Silent_p.A443A	NM_001142526	NP_001135998	Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class	443						cytoplasm|nucleus	binding			ovary(2)	2						ACATTGTTGCCAATTACTTTT	0.363			NA											7	59					2.0095e-06	2.56272e-06	0.001984	1	0
TMEM31	203562	broad.mit.edu	37	X	102968776	102968776	+	Silent	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:102968776C>A	uc004elh.2	+	3	548	c.357C>A	c.(355-357)ATC>ATA	p.I119I	GLRA4_uc011mse.1_Intron	NM_182541	NP_872347	Q5JXX7	TMM31_HUMAN	transmembrane protein 31	119	Helical; (Potential).					integral to membrane					0						TGGAAAAGATCGGACTGCCCA	0.373			NA											14	80					4.63292e-17	7.48395e-17	0.008871	1	0
ZCCHC16	340595	broad.mit.edu	37	X	111698533	111698533	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:111698533C>T	uc004epo.1	+	3	1018	c.577C>T	c.(577-579)CAG>TAG	p.Q193*		NM_001004308	NP_001004308	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	193							nucleic acid binding|zinc ion binding			ovary(1)	1						TGATCCCAACCAGGATGAAGA	0.473			NA											19	76					0	0	0.001523	0	0
IGSF1	3547	broad.mit.edu	37	X	130412049	130412049	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:130412049G>T	uc004ewd.2	-	13	2339	c.2101C>A	c.(2101-2103)CTC>ATC	p.L701I	IGSF1_uc004ewe.3_Missense_Mutation_p.L695I|IGSF1_uc004ewf.2_Missense_Mutation_p.L681I	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	701	Extracellular (Potential).|Ig-like C2-type 7.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						TTGCACCGGAGTTGTAGTTCC	0.522			NA											27	109					5.91797e-21	9.91574e-21	0.002445	1	0
FAM127C	441518	broad.mit.edu	37	X	134156229	134156229	+	Silent	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:134156229C>T	uc004eyc.1	-	1	338	c.261G>A	c.(259-261)GAG>GAA	p.E87E		NM_001078173	NP_001071641	Q17RB0	F127C_HUMAN	family with sequence similarity 127, member C	87											0	Acute lymphoblastic leukemia(192;0.000127)					GGAGGGGGCTCTCCTTCTTGA	0.627			NA											11	40					0	0	0.000978	0	0
FAM127A	8933	broad.mit.edu	37	X	134166554	134166554	+	Silent	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:134166554G>T	uc004eyd.2	+	1	222	c.141G>T	c.(139-141)ACG>ACT	p.T47T	uc004eye.1_RNA	NM_001078171	NP_001071639	A6ZKI3	F127A_HUMAN	family with sequence similarity 127, member A	47											0	Acute lymphoblastic leukemia(192;0.000127)					TCGTGCAGACGGGCTCCTACA	0.637			NA											16	71					1.96292e-10	2.79783e-10	0.001523	1	0
BGN	633	broad.mit.edu	37	X	152772061	152772061	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:152772061C>T	uc004fhr.1	+	5	812	c.640C>T	c.(640-642)CGC>TGC	p.R214C	BGN_uc004fhq.1_RNA	NM_001711	NP_001702	P21810	PGS1_HUMAN	biglycan preproprotein	214	LRR 6.					proteinaceous extracellular matrix|transport vesicle	extracellular matrix structural constituent			breast(2)	2	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAACTACCTGCGCATCTCAGA	0.602			NA											7	62					0	0	0.004482	0	0
NAA10	8260	broad.mit.edu	37	X	153197846	153197846	+	Silent	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:153197846C>T	uc004fjm.1	-	5	375	c.264G>A	c.(262-264)CAG>CAA	p.Q88Q	NAA10_uc004fjn.1_Silent_p.Q88Q|NAA10_uc011mzg.1_Silent_p.Q88Q	NM_003491	NP_003482	P41227	NAA10_HUMAN	alpha-N-acetyltransferase 1A	88	N-acetyltransferase.				DNA packaging|internal protein amino acid acetylation|N-terminal protein amino acid acetylation	cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			ovary(1)	1						CCATCAGTTTCTGAGCCAGAC	0.587	Ovarian(94;1099 1433 38814 45882 51063)		NA											3	41					0	0	0.000602	0	0
HCFC1	3054	broad.mit.edu	37	X	153220568	153220568	+	Silent	SNP	G	G	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:153220568G>A	uc004fjp.2	-	17	3810	c.3282C>T	c.(3280-3282)GCC>GCT	p.A1094A		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	1094	HCF repeat 2.				cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGTtggaggtggcggtggtgg	0.547			NA											15	53					0	0	0.001882	0	0
TKTL1	8277	broad.mit.edu	37	X	153551630	153551630	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:153551630C>A	uc004fkg.2	+	9	1450	c.1264C>A	c.(1264-1266)CCA>ACA	p.P422T	TKTL1_uc011mzl.1_Missense_Mutation_p.P416T|TKTL1_uc011mzm.1_Missense_Mutation_p.P218T|TKTL1_uc004fkh.2_Missense_Mutation_p.P366T	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	422					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GATCTTCTACCCAACTGATGC	0.517			NA											21	81					3.28513e-13	4.99911e-13	0.003954	1	0
F8	2157	broad.mit.edu	37	X	154158272	154158272	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:154158272G>T	uc004fmt.2	-	14	3964	c.3793C>A	c.(3793-3795)CCA>ACA	p.P1265T		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	1265	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TGAAGTACTGGAGCATATGCC	0.373			NA											9	44					1.76689e-08	2.39901e-08	0.006214	1	0
Unknown	0	broad.mit.edu	37	X	155254961	155254961	+	Silent	SNP	C	C	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chrX:155254961C>T	uc004fnx.3	+	9	1171	c.717C>T	c.(715-717)CGC>CGT	p.R239R		NM_182905	NP_878908			WAS protein family homolog 1												NA						CCTTTGCCCGCGTGTCAGACT	0.642			NA											7	12					0	0	0.00308	0	0
NOL4	8715	broad.mit.edu	37	18	31709851	31709851	+	Frame_Shift_Del	DEL	T	T	-			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr18:31709851delT	uc010dmi.2	-	2	627	c.398delA	c.(397-399)AAGfs	p.K133fs	NOL4_uc002kxr.3_5'UTR|NOL4_uc010xbt.1_Frame_Shift_Del_p.K59fs|NOL4_uc010dmh.2_Frame_Shift_Del_p.K59fs|NOL4_uc010xbu.1_Frame_Shift_Del_p.K133fs|NOL4_uc002kxt.3_Frame_Shift_Del_p.K133fs|NOL4_uc010xbw.1_Frame_Shift_Del_p.K19fs	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	133						nucleolus	RNA binding			ovary(3)	3						GTAAGTTCTCTTTTGTCCAGC	0.358			NA											16	62	---	---	---	---	NA	NA	NA	NA	NA
FHOD3	80206	broad.mit.edu	37	18	34289064	34289064	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr18:34289064delC	uc002kzt.1	+	14	1764	c.1667delC	c.(1666-1668)GCCfs	p.A556fs	FHOD3_uc002kzr.1_Frame_Shift_Del_p.A556fs|FHOD3_uc002kzs.1_Frame_Shift_Del_p.A573fs|FHOD3_uc010dmz.1_Frame_Shift_Del_p.A288fs|FHOD3_uc010dna.1_5'UTR	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	556					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CCAGCAAGTGCCGGGGATCCT	0.522			NA											48	213	---	---	---	---	NA	NA	NA	NA	NA
ZNF761	388561	broad.mit.edu	37	19	53959847	53959847	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr19:53959847delG	uc010eqp.2	+	7	2544	c.2086delG	c.(2086-2088)GGCfs	p.G696fs	ZNF761_uc010ydy.1_Frame_Shift_Del_p.G642fs|ZNF761_uc002qbt.1_Frame_Shift_Del_p.G642fs	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	696	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		TAATGAGTGTGGCAAGAACTT	0.393			NA											14	99	---	---	---	---	NA	NA	NA	NA	NA
NPHP1	4867	broad.mit.edu	37	2	110881617	110881625	+	In_Frame_Del	DEL	GGACTTCAG	GGACTTCAG	-			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	GGACTTCAG	GGACTTCAG	-	-	GGACTTCAG	GGACTTCAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr2:110881617_110881625delGGACTTCAG	uc002tfn.3	-	20	2036_2044	c.1942_1950delCTGAAGTCC	c.(1942-1950)CTGAAGTCCdel	p.LKS648del	NPHP1_uc002tfm.3_In_Frame_Del_p.LKS593del|NPHP1_uc002tfl.3_In_Frame_Del_p.LKS649del|NPHP1_uc002tfo.3_In_Frame_Del_p.LKS530del|NPHP1_uc010ywx.1_In_Frame_Del_p.LKS592del	NM_207181	NP_997064	O15259	NPHP1_HUMAN	nephrocystin 1 isoform 2	648_650					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			ovary(2)	2						GGAGAAACGTGGACTTCAGGAACTCTTTG	0.459			NA											15	63	---	---	---	---	NA	NA	NA	NA	NA
CNTN6	27255	broad.mit.edu	37	3	1339578	1339579	+	Frame_Shift_Ins	INS	-	-	T			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr3:1339578_1339579insT	uc003boz.2	+	7	931_932	c.664_665insT	c.(664-666)ATGfs	p.M222fs	CNTN6_uc010hbo.2_Frame_Shift_Ins_p.M217fs|CNTN6_uc011asj.1_Frame_Shift_Ins_p.M150fs|CNTN6_uc003bpa.2_Frame_Shift_Ins_p.M222fs	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	222					axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AACAGGTGTGATGGGGGAATAT	0.351			NA											19	69	---	---	---	---	NA	NA	NA	NA	NA
MKRN2	23609	broad.mit.edu	37	3	12623307	12623308	+	Frame_Shift_Ins	INS	-	-	A			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr3:12623307_12623308insA	uc003bxd.2	+	7	1025_1026	c.969_970insA	c.(967-972)GGGAAAfs	p.G323fs	MKRN2_uc003bxe.2_Frame_Shift_Ins_p.G321fs|MKRN2_uc011aus.1_Frame_Shift_Ins_p.G280fs	NM_014160	NP_054879	Q9H000	MKRN2_HUMAN	makorin ring finger protein 2	323_324	C3H1-type 4.					intracellular	ligase activity|nucleic acid binding|zinc ion binding				0						TGCTTTTCAGGAAAAAAGCCTG	0.45			NA											7	49	---	---	---	---	NA	NA	NA	NA	NA
IGF2R	3482	broad.mit.edu	37	6	160464274	160464277	+	Frame_Shift_Del	DEL	AGGC	AGGC	-			TCGA-55-7911-01A-11D-2167-08	TCGA-55-7911-10A-01D-2167-08	AGGC	AGGC	-	-	AGGC	AGGC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	de6ded5a-1646-40fa-80a8-c916cef5dd94	c3cdccd4-e903-42d8-ac96-0a11e8fb9be4	g.chr6:160464274_160464277delAGGC	uc003qta.2	+	12	1723_1726	c.1575_1578delAGGC	c.(1573-1578)GAAGGCfs	p.E525fs		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	525_526	4.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		TGCTGCAGGAAGGCAAGGCACGAG	0.505			NA											11	109	---	---	---	---	NA	NA	NA	NA	NA
