Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CASZ1	54897	broad.mit.edu	37	1	10725565	10725565	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:10725565C>T	uc001aro.2	-	5	400	c.80G>A	c.(79-81)GGT>GAT	p.G27D	CASZ1_uc001arp.1_Missense_Mutation_p.G27D|CASZ1_uc009vmx.2_Missense_Mutation_p.G51D	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	27					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CTTCAGGCCACCCTTGCGTTT	0.692			NA											2	1					0	0	0.004672	0	0
AKR7A3	22977	broad.mit.edu	37	1	19610596	19610596	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:19610596T>A	uc001bbv.1	-	6	805	c.728A>T	c.(727-729)GAG>GTG	p.E243V		NM_012067	NP_036199	O95154	ARK73_HUMAN	aldo-keto reductase family 7, member A3	243					cellular aldehyde metabolic process	cytosol	aldo-keto reductase (NADP) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;1.78e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00276)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GGCAATGCCCTCAAAGTGGTG	0.647			NA											12	6					0	0	0.00245	0	0
ARID1A	8289	broad.mit.edu	37	1	27106171	27106171	+	Nonsense_Mutation	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:27106171A>T	uc001bmv.1	+	20	6155	c.5782A>T	c.(5782-5784)AAG>TAG	p.K1928*	ARID1A_uc001bmu.1_Nonsense_Mutation_p.K1711*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.K774*|ARID1A_uc009vsm.1_Nonsense_Mutation_p.K256*|ARID1A_uc009vsn.1_Nonsense_Mutation_p.K170*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1928					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GGATGGAGCTAAGAGTTCAGA	0.542			NA	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								174	157					0	0	0.00361	0	0
TMEM222	84065	broad.mit.edu	37	1	27658583	27658583	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:27658583A>T	uc001bnr.3	+	3	355	c.302A>T	c.(301-303)AAG>ATG	p.K101M	TMEM222_uc001bns.3_RNA|TMEM222_uc001bnt.3_RNA|TMEM222_uc001bnu.3_RNA	NM_032125	NP_115501	Q9H0R3	TM222_HUMAN	transmembrane protein 222	101	Cytoplasmic (Potential).			K -> E (in Ref. 5; BAD96362).		integral to membrane	protein binding				0						GCCTTTGGAAAGCCTGCCAAG	0.577			NA											82	72					0	0	0.00361	0	0
PHACTR4	65979	broad.mit.edu	37	1	28807101	28807101	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:28807101G>A	uc001bpw.2	+	9	2027	c.1745G>A	c.(1744-1746)GGA>GAA	p.G582E	PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Missense_Mutation_p.G566E|PHACTR4_uc001bpy.2_Missense_Mutation_p.G592E	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	582							actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		CACCAGATTGGAAACACACTG	0.403			NA											69	258					0	0	0.00361	0	0
DCDC2B	149069	broad.mit.edu	37	1	32678391	32678391	+	Silent	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:32678391G>A	uc001bun.2	+	6	711	c.711G>A	c.(709-711)CAG>CAA	p.Q237Q		NM_001099434	NP_001092904	A2VCK2	DCD2B_HUMAN	doublecortin domain containing 2B	237					intracellular signal transduction						0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CCCACAGGCAGGGGGTAGGTG	0.552			NA											12	44					0	0	0.004007	0	0
AK2	204	broad.mit.edu	37	1	33478994	33478994	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:33478994C>T	uc001bwp.1	-	6	550	c.508G>A	c.(508-510)GAA>AAA	p.E170K	uc001bwn.2_Intron|AK2_uc001bwo.1_Missense_Mutation_p.E170K|AK2_uc010ohq.1_Missense_Mutation_p.E162K|AK2_uc009vud.1_Missense_Mutation_p.E128K|AK2_uc010ohr.1_Missense_Mutation_p.E122K|AK2_uc001bwq.1_Missense_Mutation_p.E122K	NM_001625	NP_001616	P54819	KAD2_HUMAN	adenylate kinase 2 isoform a	170					nucleobase, nucleoside and nucleotide interconversion	mitochondrial intermembrane space	adenylate kinase activity|ATP binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				ATCAAGGGTTCCCCGGTGATC	0.473			NA											8	18					0	0	0.006214	0	0
SPATA6	54558	broad.mit.edu	37	1	48850997	48850997	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:48850997C>A	uc001crr.1	-	9	1058	c.893G>T	c.(892-894)CGA>CTA	p.R298L	SPATA6_uc001crs.1_Missense_Mutation_p.R298L|SPATA6_uc010omv.1_Missense_Mutation_p.R284L	NM_019073	NP_061946	Q9NWH7	SPAT6_HUMAN	spermatogenesis associated 6 precursor	298					cell differentiation|multicellular organismal development|spermatogenesis	extracellular region				ovary(1)	1						ATCCTTGGGTCGGCAGCAGCC	0.299			NA											9	40					0.006122	0.00632127	0.006122	1	0
CC2D1B	200014	broad.mit.edu	37	1	52821917	52821917	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:52821917C>A	uc001ctq.1	-	18	2151	c.2013G>T	c.(2011-2013)CAG>CAT	p.Q671H	CC2D1B_uc001ctr.2_Missense_Mutation_p.Q211H|CC2D1B_uc001cts.2_Missense_Mutation_p.Q356H	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	671										ovary(2)	2						GGCCCTGAGCCTGGGCCAGCT	0.567			NA											26	92					5.60225e-13	6.89415e-13	0.009535	1	0
LRRC40	55631	broad.mit.edu	37	1	70652948	70652948	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:70652948C>A	uc001der.1	-	3	459	c.407G>T	c.(406-408)AGC>ATC	p.S136I		NM_017768	NP_060238	Q9H9A6	LRC40_HUMAN	leucine rich repeat containing 40	136	LRR 3.									ovary(1)	1						TAATTTTTACCTGACATTAAG	0.249			NA											15	9					5.03518e-11	5.98977e-11	0.007413	1	0
MCOLN2	255231	broad.mit.edu	37	1	85418191	85418191	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:85418191C>A	uc001dkm.2	-	5	829	c.588G>T	c.(586-588)CAG>CAT	p.Q196H	MCOLN2_uc001dkn.2_RNA	NM_153259	NP_694991	Q8IZK6	MCLN2_HUMAN	mucolipin 2	196						integral to membrane	ion channel activity			ovary(3)|upper_aerodigestive_tract(1)	4				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		TGGAGAGGTCCTGAAGGTCTA	0.279			NA											59	35					3.41413e-29	4.9105e-29	0.00361	1	0
HSP90B3P	343477	broad.mit.edu	37	1	92109180	92109180	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:92109180G>T	uc010osx.1	+	3	1207	c.1207G>T	c.(1207-1209)GTG>TTG	p.V403L		NR_003130				SubName: Full=cDNA FLJ58812, highly similar to Endoplasmin (Heat shock protein 90kDa beta member 1);												0						GTGTGCTTTGGTGGCCAGCCA	0.473			NA											33	17					4.67007e-22	6.42556e-22	0.00874	1	0
COL11A1	1301	broad.mit.edu	37	1	103471410	103471410	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:103471410C>A	uc001dul.2	-	18	2147	c.1829G>T	c.(1828-1830)GGT>GTT	p.G610V	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.G622V|COL11A1_uc001dun.2_Missense_Mutation_p.G571V|COL11A1_uc009weh.2_Missense_Mutation_p.G494V	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	610	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ACCTTTGTCACCTGGCAGACC	0.308			NA											74	58					8.2166e-39	1.29247e-38	0.00361	1	0
VAV3	10451	broad.mit.edu	37	1	108315358	108315358	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:108315358G>T	uc001dvk.1	-	5	608	c.554C>A	c.(553-555)CCC>CAC	p.P185H	VAV3_uc010ouw.1_Missense_Mutation_p.P185H|VAV3_uc001dvl.1_Missense_Mutation_p.P9H|VAV3_uc010oux.1_Missense_Mutation_p.P185H	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	185					angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		AAGTCCTACGGGCTGATGTGC	0.348			NA											62	23					6.20203e-27	8.76575e-27	0.00361	1	0
NBPF7	343505	broad.mit.edu	37	1	120381810	120381810	+	Silent	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:120381810G>A	uc010oxk.1	-	5	1456	c.835C>T	c.(835-837)CTG>TTG	p.L279L		NM_001047980	NP_001041445	P0C2Y1	NBPF7_HUMAN	hypothetical protein LOC343505	279	NBPF 1.					cytoplasm				ovary(1)|skin(1)	2	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;3.66e-05)|Lung NSC(69;0.000192)|all_epithelial(167;0.0347)		Lung(183;0.0103)|LUSC - Lung squamous cell carcinoma(189;0.0544)		AGGTTACCCAGAAGAATGTTT	0.388			NA											6	205					0	0	0.001984	0	0
NBPF7	343505	broad.mit.edu	37	1	120381813	120381813	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:120381813G>A	uc010oxk.1	-	5	1453	c.832C>T	c.(832-834)CTT>TTT	p.L278F		NM_001047980	NP_001041445	P0C2Y1	NBPF7_HUMAN	hypothetical protein LOC343505	278	NBPF 1.					cytoplasm				ovary(1)|skin(1)	2	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;3.66e-05)|Lung NSC(69;0.000192)|all_epithelial(167;0.0347)		Lung(183;0.0103)|LUSC - Lung squamous cell carcinoma(189;0.0544)		TTACCCAGAAGAATGTTTAGA	0.388			NA											7	227					0	0	0.004482	0	0
PIP5K1A	8394	broad.mit.edu	37	1	151171540	151171540	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:151171540C>T	uc001exj.2	+	1	520	c.68C>T	c.(67-69)TCC>TTC	p.S23F	PIP5K1A_uc001exi.2_Missense_Mutation_p.S23F|PIP5K1A_uc010pcu.1_Missense_Mutation_p.S23F|PIP5K1A_uc001exk.2_Missense_Mutation_p.S23F	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	23					phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			GCGGTCCCTTCCTGTACCTTG	0.627	Pancreas(80;36 1443 2325 16095 21302)		NA											24	17					0	0	0.004656	0	0
FLG	2312	broad.mit.edu	37	1	152285860	152285860	+	Missense_Mutation	SNP	C	C	T	rs145828067		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:152285860C>T	uc001ezu.1	-	3	1538	c.1502G>A	c.(1501-1503)CGA>CAA	p.R501Q	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	501	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGAGCTGTCTCGTGCCTGCTC	0.612			NA							Ichthyosis				10	300					0	0	0.000978	0	0
FLG2	388698	broad.mit.edu	37	1	152329021	152329021	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:152329021G>A	uc001ezw.3	-	3	1314	c.1241C>T	c.(1240-1242)TCC>TTC	p.S414F	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	414	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATCACATTTGGAAAATTCATT	0.423			NA											45	158					0	0	0.00361	0	0
LCE2C	353140	broad.mit.edu	37	1	152648744	152648744	+	Silent	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:152648744C>A	uc001fah.2	+	2	308	c.253C>A	c.(253-255)CGG>AGG	p.R85R		NM_178429	NP_848516	Q5TA81	LCE2C_HUMAN	late cornified envelope 2C	85	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCACCGGCGCCGGCACCAGAG	0.682			NA											11	12					4.96729e-08	5.62762e-08	0.008871	1	0
ILF2	3608	broad.mit.edu	37	1	153640105	153640105	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:153640105G>A	uc001fcr.2	-	6	401	c.320C>T	c.(319-321)TCC>TTC	p.S107F	ILF2_uc010pdy.1_Missense_Mutation_p.S69F|ILF2_uc009wok.2_Missense_Mutation_p.S107F|ILF2_uc009wol.1_Missense_Mutation_p.S69F	NM_004515	NP_004506	Q12905	ILF2_HUMAN	interleukin enhancer binding factor 2	107	DZF.				immune response|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|ribonucleoprotein complex	ATP binding|DNA binding|double-stranded RNA binding|protein binding|transferase activity				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTTTTTATAGGATCCCACCTG	0.448			NA											31	384					0	0	0.002522	0	0
INSRR	3645	broad.mit.edu	37	1	156812834	156812834	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:156812834C>A	uc010pht.1	-	17	3342	c.3088G>T	c.(3088-3090)GAA>TAA	p.E1030*	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	1030	Cytoplasmic (Potential).|Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					ACAGAAGCTTCCTTGAGGAAC	0.527			NA											42	48					1.0096e-33	1.51308e-33	0.00361	1	0
FCRL5	83416	broad.mit.edu	37	1	157516811	157516811	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:157516811C>A	uc001fqu.2	-	3	387	c.229G>T	c.(229-231)GTT>TTT	p.V77F	FCRL5_uc009wsm.2_Missense_Mutation_p.V77F|FCRL5_uc010phv.1_Missense_Mutation_p.V77F|FCRL5_uc010phw.1_Intron|FCRL5_uc001fqv.1_Missense_Mutation_p.V77F|FCRL5_uc010phx.1_5'UTR	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	77	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GATTCCTGAACCTCAAGGATA	0.483			NA											21	34					0.000229342	0.000242508	0.001882	1	0
OR6N1	128372	broad.mit.edu	37	1	158736093	158736093	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:158736093C>T	uc010piq.1	-	1	380	c.380G>A	c.(379-381)TGC>TAC	p.C127Y		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	127	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GAGGGGCCGGCAGATGGCTAA	0.522			NA											47	46					0	0	0.00361	0	0
IFI16	3428	broad.mit.edu	37	1	159021844	159021844	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:159021844C>A	uc001ftg.2	+	9	2163	c.1873C>A	c.(1873-1875)CAA>AAA	p.Q625K	IFI16_uc010pis.1_Missense_Mutation_p.Q625K|IFI16_uc001fth.2_Missense_Mutation_p.Q168K|IFI16_uc010pit.1_Missense_Mutation_p.Q224K	NM_005531	NP_005522	Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	681	HIN-200 2.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)					GCTTTGCTCACAAACTAAAGG	0.398			NA											4	28					1.23904e-05	1.34249e-05	0.000602	1	0
CADM3	57863	broad.mit.edu	37	1	159163301	159163301	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:159163301C>A	uc001ftl.2	+	4	613	c.471C>A	c.(469-471)AGC>AGA	p.S157R	CADM3_uc009wsx.1_Missense_Mutation_p.S191R|CADM3_uc009wsy.1_Missense_Mutation_p.S157R|CADM3_uc001ftk.2_Missense_Mutation_p.S191R	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	157	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					CTTCTGGGAGCAAGCCTGCAG	0.512			NA											26	37					4.4194e-11	5.26822e-11	0.002836	1	0
ATP1A2	477	broad.mit.edu	37	1	160100252	160100252	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:160100252G>T	uc001fvc.2	+	13	1824	c.1692G>T	c.(1690-1692)CGG>CGT	p.R564R	ATP1A2_uc001fvb.2_Silent_p.R564R|ATP1A2_uc001fvd.2_Silent_p.R300R|ATP1A2_uc009wtg.1_Silent_p.R252R	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	564	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			AGTTTCCTCGGGGCTTCAAAT	0.552			NA											36	37					2.01872e-29	2.91082e-29	0.00361	1	0
F5	2153	broad.mit.edu	37	1	169513566	169513566	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:169513566C>T	uc001ggg.1	-	12	2088	c.1943G>A	c.(1942-1944)GGA>GAA	p.G648E		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	648	Plastocyanin-like 4.|F5/8 type A 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CACAGATTCTCCACGCATGGG	0.478			NA											54	229					0	0	0.00361	0	0
C1orf156	92342	broad.mit.edu	37	1	169762027	169762027	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:169762027C>A	uc001ggn.2	-	2	1088	c.810G>T	c.(808-810)TGG>TGT	p.W270C	C1orf112_uc001ggj.2_Intron|C1orf112_uc001ggo.2_5'Flank|uc010plt.1_5'Flank|C1orf112_uc001ggp.2_5'Flank|C1orf112_uc001ggq.2_5'Flank|C1orf112_uc009wvt.2_5'Flank	NM_033418	NP_219486	O95568	MET18_HUMAN	hypothetical protein MGC9084	270						cytoplasm	protein methyltransferase activity				0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AAAACTCAGACCACTCACCAG	0.328			NA											41	45					8.69298e-16	1.09574e-15	0.006999	1	0
TNN	63923	broad.mit.edu	37	1	175086125	175086125	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:175086125G>T	uc001gkl.1	+	10	2283	c.2170G>T	c.(2170-2172)GCC>TCC	p.A724S		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	724	Fibronectin type-III 6.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGAGAATATGGCCACTGTCTC	0.537			NA											54	65					7.92265e-33	1.17808e-32	0.00361	1	0
SEC16B	89866	broad.mit.edu	37	1	177901902	177901902	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:177901902C>A	uc001gli.1	-	23	2953	c.2863G>T	c.(2863-2865)GGC>TGC	p.G955C	SEC16B_uc001glk.1_Missense_Mutation_p.G632C|SEC16B_uc009wwy.1_Intron|SEC16B_uc001glh.1_Missense_Mutation_p.G615C|SEC16B_uc009wwz.1_Missense_Mutation_p.G614C|SEC16B_uc001glj.1_Missense_Mutation_p.G956C	NM_033127	NP_149118	Q96JE7	SC16B_HUMAN	leucine zipper transcription regulator 2	955					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				ovary(3)|central_nervous_system(1)	4						AGTGAGAGGCCCAGGCCAGCC	0.587			NA											19	13					2.52088e-20	3.37892e-20	0.00278	1	0
ABL2	27	broad.mit.edu	37	1	179076967	179076967	+	Silent	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:179076967G>A	uc001gmj.3	-	12	3722	c.3435C>T	c.(3433-3435)CTC>CTT	p.L1145L	ABL2_uc010pnf.1_Silent_p.L1042L|ABL2_uc010png.1_Silent_p.L1021L|ABL2_uc010pnh.1_Silent_p.L1124L|ABL2_uc001gmg.3_Silent_p.L1027L|ABL2_uc001gmi.3_Silent_p.L1130L|ABL2_uc001gmh.3_Silent_p.L1109L|ABL2_uc010pne.1_Silent_p.L1006L	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	1145	F-actin-binding (By similarity).				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	CCTGCAGGCTGAGTTCCAGTT	0.507			NA	T	ETV6	AML								4	46					0	0	0.009096	0	0
ABL2	27	broad.mit.edu	37	1	179079508	179079508	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:179079508C>A	uc001gmj.3	-	11	2021	c.1734G>T	c.(1732-1734)AAG>AAT	p.K578N	ABL2_uc010pnf.1_Missense_Mutation_p.K578N|ABL2_uc010png.1_Missense_Mutation_p.K557N|ABL2_uc010pnh.1_Missense_Mutation_p.K557N|ABL2_uc001gmg.3_Missense_Mutation_p.K563N|ABL2_uc001gmi.3_Missense_Mutation_p.K563N|ABL2_uc001gmh.3_Missense_Mutation_p.K542N|ABL2_uc010pne.1_Missense_Mutation_p.K542N	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	578					axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	GTGTCCGAGTCTTGGAAGGAA	0.522			NA	T	ETV6	AML								69	164					4.8811e-34	7.3733e-34	0.00361	1	0
CACNA1E	777	broad.mit.edu	37	1	181684527	181684527	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:181684527G>T	uc001gow.2	+	9	1390	c.1225G>T	c.(1225-1227)GTG>TTG	p.V409L	CACNA1E_uc009wxs.2_Missense_Mutation_p.V316L	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	409	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CGCCTTAGAAGGTAAGGAAAT	0.383			NA											6	28					0.000157383	0.000167037	0.00308	1	0
GLRX2	51022	broad.mit.edu	37	1	193066850	193066850	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:193066850G>T	uc001gsz.1	-	3	268	c.224C>A	c.(223-225)ACA>AAA	p.T75K	GLRX2_uc001gta.1_Missense_Mutation_p.T76K	NM_197962	NP_932066	Q9NS18	GLRX2_HUMAN	glutaredoxin 2 isoform 2	75	Glutaredoxin.				apoptosis|cell differentiation|cell redox homeostasis|DNA protection|electron transport chain|glutathione metabolic process|protein thiol-disulfide exchange|regulation of signal transduction|regulation of transcription, DNA-dependent|response to hydrogen peroxide|response to organic substance|response to redox state|response to temperature stimulus|transport	mitochondrion|nucleus	2 iron, 2 sulfur cluster binding|arsenate reductase (glutaredoxin) activity|electron carrier activity|glutathione disulfide oxidoreductase activity|metal ion binding|protein disulfide oxidoreductase activity				0					Glutathione(DB00143)	AGAACAGGATGTTTTTGAGAA	0.313			NA											5	16					6.5536e-12	7.92819e-12	0.00308	1	0
PIK3C2B	5287	broad.mit.edu	37	1	204394057	204394057	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:204394057G>A	uc001haw.2	-	34	5307	c.4828C>T	c.(4828-4830)CGC>TGC	p.R1610C	PIK3C2B_uc010pqv.1_Missense_Mutation_p.R1582C	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	1610					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			TCTCGCAGGCGGATGTTCACC	0.637			NA											30	33					0	0	0.005524	0	0
LGTN	1939	broad.mit.edu	37	1	206784620	206784620	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:206784620G>A	uc001heh.2	-	2	373	c.164C>T	c.(163-165)GCT>GTT	p.A55V	LGTN_uc009xbw.2_Missense_Mutation_p.A55V|LGTN_uc010prw.1_Missense_Mutation_p.A55V	NM_006893	NP_008824	P41214	EIF2D_HUMAN	ligatin	55					intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			CCCTTTGTGAGCATACAACTT	0.473			NA											38	149					0	0	0.005524	0	0
PROX1	5629	broad.mit.edu	37	1	214170382	214170382	+	Silent	SNP	G	G	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:214170382G>C	uc001hkh.2	+	2	776	c.504G>C	c.(502-504)CGG>CGC	p.R168R	PROX1_uc001hkg.1_Silent_p.R168R	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	168					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		AGCGCGCCCGGGTTGAGAATA	0.532			NA											14	58					0	0	0.010504	0	0
KCNK2	3776	broad.mit.edu	37	1	215345403	215345403	+	Missense_Mutation	SNP	T	T	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:215345403T>G	uc001hkq.2	+	5	869	c.700T>G	c.(700-702)TGT>GGT	p.C234G	KCNK2_uc001hko.2_Missense_Mutation_p.C230G|KCNK2_uc009xdm.2_Intron|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Missense_Mutation_p.C219G	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	234	Helical; (Potential).						outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	ACTATTTGGCTGTGTACTCTT	0.393			NA											94	140					0	0	0.00361	0	0
KCTD3	51133	broad.mit.edu	37	1	215792515	215792515	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:215792515G>T	uc001hks.2	+	17	2062	c.1768G>T	c.(1768-1770)GAA>TAA	p.E590*	KCTD3_uc001hkt.2_Nonsense_Mutation_p.E588*|KCTD3_uc010pub.1_Nonsense_Mutation_p.E488*|KCTD3_uc009xdn.2_Nonsense_Mutation_p.E314*	NM_016121	NP_057205	Q9Y597	KCTD3_HUMAN	potassium channel tetramerisation domain	590						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		TCCAACCGAAGAAGAGCTACT	0.403			NA											51	157					2.5401e-28	3.64421e-28	0.00361	1	0
DISP1	84976	broad.mit.edu	37	1	223177391	223177391	+	Silent	SNP	G	G	A	rs138904556	by1000genomes	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:223177391G>A	uc001hnu.1	+	8	2799	c.2652G>A	c.(2650-2652)GAG>GAA	p.E884E		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	884					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		ACAAGCAAGAGATTTTTGAAC	0.488			NA											13	51					0	0	0.00499	0	0
DISP1	84976	broad.mit.edu	37	1	223177398	223177398	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:223177398G>A	uc001hnu.1	+	8	2806	c.2659G>A	c.(2659-2661)GAA>AAA	p.E887K		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	887					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		AGAGATTTTTGAACTGTGCAT	0.478			NA											12	50					0	0	0.004007	0	0
GNPAT	8443	broad.mit.edu	37	1	231403468	231403468	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:231403468C>T	uc001hup.3	+	9	1304	c.1098C>T	c.(1096-1098)GTC>GTT	p.V366V	GNPAT_uc009xfp.2_Silent_p.V305V	NM_014236	NP_055051	O15228	GNPAT_HUMAN	glyceronephosphate O-acyltransferase	366					ether lipid biosynthetic process|fatty acid metabolic process|organ morphogenesis	peroxisomal matrix|peroxisomal membrane	glycerone-phosphate O-acyltransferase activity			ovary(3)|breast(1)	4	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				ATGCCTTTGTCACTGAAGTTG	0.433			NA											15	172					0	0	0.008871	0	0
LYST	1130	broad.mit.edu	37	1	235909776	235909776	+	Missense_Mutation	SNP	C	C	T	rs147536126	byFrequency	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:235909776C>T	uc001hxj.2	-	29	8007	c.7832G>A	c.(7831-7833)CGT>CAT	p.R2611H	LYST_uc009xga.1_Missense_Mutation_p.R247H	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2611					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TGCCACTGAACGCATTTTCAT	0.408			NA							Chediak-Higashsyndrome				35	42					0	0	0.00623	0	0
ACTN2	88	broad.mit.edu	37	1	236882306	236882306	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:236882306C>T	uc001hyf.2	+	3	558	c.354C>T	c.(352-354)GGC>GGT	p.G118G	ACTN2_uc001hyg.2_5'UTR|ACTN2_uc009xgi.1_Silent_p.G118G	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	118	CH 1.|Actin-binding.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			TGTCCATTGGCGCTGAAGGTG	0.512			NA											14	22					0	0	0.001882	0	0
RYR2	6262	broad.mit.edu	37	1	237664075	237664075	+	Silent	SNP	T	T	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:237664075T>C	uc001hyl.1	+	21	2388	c.2268T>C	c.(2266-2268)AGT>AGC	p.S756S		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	756	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATGTCATCAGTTGCTGTTTAG	0.413			NA											172	484					0	0	0.00361	0	0
NLRP3	114548	broad.mit.edu	37	1	247597423	247597423	+	Silent	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:247597423C>A	uc001icr.2	+	7	2484	c.2346C>A	c.(2344-2346)CTC>CTA	p.L782L	NLRP3_uc001ics.2_Silent_p.L782L|NLRP3_uc001icu.2_Silent_p.L782L|NLRP3_uc001icw.2_Silent_p.L725L|NLRP3_uc001icv.2_Silent_p.L725L|NLRP3_uc010pyw.1_Intron	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	782	LRR 2.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GCTGTGGCCTCTCGCATGAGT	0.562			NA											73	200					6.79372e-55	1.1477e-54	0.00361	1	0
OR2G2	81470	broad.mit.edu	37	1	247752207	247752207	+	Silent	SNP	C	C	T	rs146695930	byFrequency	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:247752207C>T	uc010pyy.1	+	1	546	c.546C>T	c.(544-546)TGC>TGT	p.C182C		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ATTTCATCTGCGAGGTCCCTG	0.537			NA											92	273					0	0	0.00361	0	0
OR2M4	26245	broad.mit.edu	37	1	248402554	248402554	+	Silent	SNP	T	T	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:248402554T>C	uc010pzh.1	+	1	324	c.324T>C	c.(322-324)CTT>CTC	p.L108L		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	108	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGTCCCTGCTTGGAGCTGAAT	0.463			NA											56	88					0	0	0.00361	0	0
ITIH5	80760	broad.mit.edu	37	10	7659106	7659106	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:7659106G>T	uc001ijq.2	-	6	871	c.792C>A	c.(790-792)GTC>GTA	p.V264V	ITIH5_uc001ijp.2_Silent_p.V50V|ITIH5_uc001ijr.1_Silent_p.V264V	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	264					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						GTTCTCTATTGACGTCATATC	0.403			NA											131	331					8.9487e-115	1.60683e-114	0.00361	1	0
OLAH	55301	broad.mit.edu	37	10	15106469	15106469	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:15106469C>A	uc001inu.2	+	5	624	c.370C>A	c.(370-372)CAT>AAT	p.H124N	ACBD7_uc010qby.1_Intron|OLAH_uc001int.2_Missense_Mutation_p.H177N	NM_001039702	NP_001034791	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase isoform 2	124					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity				0						AGAACCATTGCATTTATTTTT	0.373			NA											24	79					1.13719e-10	1.3416e-10	0.008361	1	0
ARMC3	219681	broad.mit.edu	37	10	23257283	23257283	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:23257283C>A	uc001irm.3	+	8	864	c.781C>A	c.(781-783)CTT>ATT	p.L261I	ARMC3_uc010qcv.1_Missense_Mutation_p.L261I|ARMC3_uc010qcw.1_5'UTR	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	261	ARM 6.						binding				0						AGCCAATTGCCTTGAAGACAT	0.358			NA											109	225					4.30233e-46	6.99895e-46	0.00361	1	0
ARHGAP12	94134	broad.mit.edu	37	10	32197269	32197269	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:32197269T>A	uc001ivz.1	-	3	785	c.515A>T	c.(514-516)AAT>ATT	p.N172I	ARHGAP12_uc001ivy.1_Missense_Mutation_p.N170I|ARHGAP12_uc009xls.2_Missense_Mutation_p.N170I|ARHGAP12_uc001iwb.1_Missense_Mutation_p.N170I|ARHGAP12_uc001iwc.1_Missense_Mutation_p.N170I|ARHGAP12_uc009xlq.1_Missense_Mutation_p.N170I|ARHGAP12_uc001iwd.1_Missense_Mutation_p.N170I|ARHGAP12_uc009xlr.1_Missense_Mutation_p.N170I	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	172					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				GCGTGTCCTATTCTGGCTGGA	0.443			NA											133	247					0	0	0.00361	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430752	37430752	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:37430752G>T	uc001iza.1	+	7	858	c.759G>T	c.(757-759)TTG>TTT	p.L253F		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	309						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CTGCACCCTTGGTGGAAAGAA	0.502			NA											22	27					6.12954e-19	8.02744e-19	0.004656	1	0
GDF2	2658	broad.mit.edu	37	10	48413794	48413794	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:48413794G>T	uc001jfa.1	-	2	1237	c.1074C>A	c.(1072-1074)GGC>GGA	p.G358G		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	358					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						AGAAGCAGCCGCCCTTACACT	0.572			NA											17	11					5.26018e-13	6.48717e-13	0.001882	1	0
FRMPD2	143162	broad.mit.edu	37	10	49393636	49393636	+	Silent	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:49393636A>T	uc001jgi.2	-	18	2426	c.2319T>A	c.(2317-2319)ATT>ATA	p.I773I	FRMPD2_uc001jgh.2_Silent_p.I741I|FRMPD2_uc001jgj.2_Silent_p.I751I	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	773					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		TCACACGTACAATTTCTCGGC	0.498			NA											40	70					0	0	0.003214	0	0
CHAT	1103	broad.mit.edu	37	10	50870742	50870742	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:50870742G>C	uc001jhz.2	+	14	2044	c.1891G>C	c.(1891-1893)GCC>CCC	p.A631P	CHAT_uc001jhv.1_Missense_Mutation_p.A513P|CHAT_uc001jhx.1_Missense_Mutation_p.A513P|CHAT_uc001jhy.1_Missense_Mutation_p.A513P|CHAT_uc001jia.2_Missense_Mutation_p.A513P|CHAT_uc010qgs.1_Missense_Mutation_p.A513P	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	631					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	GCGGGAGCTGGCCCGGGCCAT	0.587			NA											76	95					0	0	0.00361	0	0
PCDH15	65217	broad.mit.edu	37	10	55721550	55721550	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:55721550G>T	uc001jju.1	-	22	3366	c.2971C>A	c.(2971-2973)CGA>AGA	p.R991R	PCDH15_uc010qhq.1_Silent_p.R996R|PCDH15_uc010qhr.1_Silent_p.R991R|PCDH15_uc010qhs.1_Silent_p.R1003R|PCDH15_uc010qht.1_Silent_p.R998R|PCDH15_uc010qhu.1_Silent_p.R991R|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Silent_p.R991R|PCDH15_uc010qhw.1_Silent_p.R954R|PCDH15_uc010qhx.1_Silent_p.R920R|PCDH15_uc010qhy.1_Silent_p.R996R|PCDH15_uc010qhz.1_Silent_p.R991R|PCDH15_uc010qia.1_Silent_p.R969R|PCDH15_uc010qib.1_Silent_p.R969R	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	991	Extracellular (Potential).|Cadherin 9.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				AGATTGACTCGTGTTATTACT	0.348			NA								HNSCC(58;0.16)			22	110					6.12954e-19	8.02744e-19	0.004656	1	0
LRRTM3	347731	broad.mit.edu	37	10	68857382	68857382	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:68857382A>T	uc001jmz.1	+	3	2124	c.1574A>T	c.(1573-1575)TAC>TTC	p.Y525F	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	525	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						TTTCTGGCATACGACCAGCCC	0.398			NA											42	226					0	0	0.00361	0	0
MYPN	84665	broad.mit.edu	37	10	69909858	69909858	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:69909858T>C	uc001jnm.3	+	7	1492	c.1307T>C	c.(1306-1308)GTG>GCG	p.V436A	MYPN_uc001jnl.1_Missense_Mutation_p.V436A|MYPN_uc001jnn.3_Missense_Mutation_p.V161A|MYPN_uc001jno.3_Missense_Mutation_p.V436A|MYPN_uc001jnp.1_Missense_Mutation_p.V436A|MYPN_uc009xps.2_Missense_Mutation_p.V436A|MYPN_uc009xpt.2_Missense_Mutation_p.V436A|MYPN_uc010qit.1_Missense_Mutation_p.V142A|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	436	Interaction with CARP.|Ig-like 2.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						GCAGCTCCTGTGTTTACAAAG	0.363			NA											31	97					0	0	0.003271	0	0
NODAL	4838	broad.mit.edu	37	10	72195389	72195389	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:72195389G>T	uc001jrc.2	-	2	586	c.544C>A	c.(544-546)CCG>ACG	p.P182T		NM_018055	NP_060525	Q96S42	NODAL_HUMAN	nodal precursor	182					growth	extracellular space	cytokine activity|growth factor activity			large_intestine(1)|kidney(1)	2						GGGGGCCGCGGCCAGCACTCT	0.637			NA											7	3					5.68852e-11	6.75291e-11	0.004482	1	0
CDH23	64072	broad.mit.edu	37	10	73544838	73544838	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:73544838C>T	uc001jrx.3	+	41	6070	c.5693C>T	c.(5692-5694)GCC>GTC	p.A1898V		NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	1898	Cadherin 18.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						CGCGAGCGGGCCTTCTTCATC	0.597			NA											17	26					0	0	0.00278	0	0
CDH23	64072	broad.mit.edu	37	10	73550900	73550900	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:73550900G>T	uc001jrx.3	+	45	6438	c.6061G>T	c.(6061-6063)GTG>TTG	p.V2021L		NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	2021	Cadherin 19.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						TGTGGTGACCGTGAGGTCAGG	0.622			NA											3	3					6.4e-05	6.85629e-05	0.004672	1	0
LDB3	11155	broad.mit.edu	37	10	88478508	88478508	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:88478508A>T	uc001kdv.2	+	11	1905	c.1882A>T	c.(1882-1884)ACA>TCA	p.T628S	LDB3_uc010qmm.1_Missense_Mutation_p.T633S|LDB3_uc001kdu.2_Missense_Mutation_p.T518S|LDB3_uc009xsz.2_Missense_Mutation_p.T257S|LDB3_uc009xta.1_Missense_Mutation_p.T7S	NM_007078	NP_009009	O75112	LDB3_HUMAN	LIM domain binding 3 isoform 1	628	LIM zinc-binding 2.					cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			ovary(1)	1						CTTGAGACAGACATGGCACAC	0.577			NA											34	53					0	0	0.009718	0	0
SLC16A12	387700	broad.mit.edu	37	10	91198784	91198784	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:91198784G>A	uc001kgm.2	-	6	906	c.515C>T	c.(514-516)TCC>TTC	p.S172F	SLC16A12_uc001kgl.2_5'Flank	NM_213606	NP_998771	Q6ZSM3	MOT12_HUMAN	solute carrier family 16 (monocarboxylic acid	172	Cytoplasmic (Potential).					integral to membrane|plasma membrane	symporter activity			skin(1)	1						TCCCCGCCAGGAAAACTGTTC	0.498			NA											15	177					0	0	0.006122	0	0
PPP1R3C	5507	broad.mit.edu	37	10	93390364	93390364	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:93390364C>A	uc001kho.2	-	2	406	c.274G>T	c.(274-276)GGC>TGC	p.G92C		NM_005398	NP_005389	Q9UQK1	PPR3C_HUMAN	protein phosphatase 1, regulatory (inhibitor)	92							protein serine/threonine phosphatase activity			breast(1)	1		Colorectal(252;0.235)				AGAGAGAGGCCCTTGGAGTCA	0.478			NA											21	85					3.83957e-06	4.20805e-06	0.00278	1	0
PDCD11	22984	broad.mit.edu	37	10	105198552	105198552	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:105198552G>T	uc001kwy.1	+	27	4099	c.4012G>T	c.(4012-4014)GGT>TGT	p.G1338C		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1338	S1 motif 12.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		CCAGCCACACGGTGTGTTCTT	0.552			NA											13	47					1.3612e-06	1.51215e-06	0.003163	1	0
ADD3	120	broad.mit.edu	37	10	111872586	111872586	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:111872586C>T	uc001kyt.3	+	4	561	c.247C>T	c.(247-249)CAC>TAC	p.H83Y	ADD3_uc001kys.3_Missense_Mutation_p.H83Y|ADD3_uc001kyu.2_Missense_Mutation_p.H83Y|ADD3_uc001kyv.2_Missense_Mutation_p.H83Y|ADD3_uc001kyw.2_Missense_Mutation_p.H83Y	NM_016824	NP_058432	Q9UEY8	ADDG_HUMAN	adducin 3 (gamma) isoform a	83						cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			ovary(2)|skin(2)|large_intestine(1)	5		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)		GAAGAAAGGCCACAACCCAAC	0.418			NA											70	69					0	0	0.00361	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116100464	116100464	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:116100464C>T	uc001lbn.2	-	2	344	c.43G>A	c.(43-45)GAT>AAT	p.D15N	AFAP1L2_uc001lbo.2_Missense_Mutation_p.D15N|AFAP1L2_uc010qse.1_Missense_Mutation_p.D15N|AFAP1L2_uc001lbp.2_Missense_Mutation_p.D15N|AFAP1L2_uc001lbr.1_Missense_Mutation_p.D15N	NM_001001936	NP_001001936	Q8N4X5	AF1L2_HUMAN	KIAA1914 protein isoform 1	15					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			ovary(1)|breast(1)	2		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		AGGAAGTCATCCAACTCTGTC	0.547			NA											5	60					0	0	0.000602	0	0
GPR26	2849	broad.mit.edu	37	10	125447575	125447575	+	Missense_Mutation	SNP	T	T	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:125447575T>G	uc001lhh.2	+	3	966	c.913T>G	c.(913-915)TGC>GGC	p.C305G		NM_153442	NP_703143	Q8NDV2	GPR26_HUMAN	G protein-coupled receptor 26	305	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1		Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)				CCGCAAAAGCTGCAAGGAGAT	0.592			NA											4	32					0	0	0.006214	0	0
EBF3	253738	broad.mit.edu	37	10	131671816	131671816	+	Silent	SNP	G	G	T	rs150383257		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:131671816G>T	uc001lki.1	-	8	740	c.681C>A	c.(679-681)GCC>GCA	p.A227A		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	227					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		TGTCTGACACGGCCAGCACGT	0.522			NA											14	24					2.35188e-11	2.81535e-11	0.006122	1	0
FRG2B	441581	broad.mit.edu	37	10	135440087	135440087	+	Nonsense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:135440087T>A	uc010qvg.1	-	1	213	c.160A>T	c.(160-162)AAG>TAG	p.K54*		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	54						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		TGTATGTGCTTCTCACTGGAA	0.488			NA											15	21					0	0	0.001882	0	0
SLC25A22	79751	broad.mit.edu	37	11	792399	792399	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:792399C>A	uc001lri.2	-	8	989	c.647G>T	c.(646-648)CGC>CTC	p.R216L	CEND1_uc001lrh.1_5'Flank|SLC25A22_uc009yci.2_Missense_Mutation_p.R216L|SLC25A22_uc001lrj.2_Missense_Mutation_p.R216L	NM_024698	NP_078974	Q9H936	GHC1_HUMAN	mitochondrial glutamate carrier 1	216						integral to membrane|mitochondrial inner membrane|nucleus	L-glutamate transmembrane transporter activity|protein binding|symporter activity				0		all_cancers(49;4.75e-06)|all_epithelial(84;0.00204)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;6.27e-26)|Epithelial(43;4.84e-25)|OV - Ovarian serous cystadenocarcinoma(40;2.72e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	L-Glutamic Acid(DB00142)	GGACGCCGGGCGGCCCAGCTG	0.662	Colon(93;848 1468 3270 23355 49636)		NA											6	6					2.0095e-06	2.22369e-06	0.001984	1	0
OR52A5	390054	broad.mit.edu	37	11	5153664	5153664	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:5153664G>T	uc010qyx.1	-	1	209	c.209C>A	c.(208-210)GCC>GAC	p.A70D		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		AATGTCTGTGGCTGCCAACAT	0.363			NA											35	87					1.02591e-13	1.27346e-13	0.002522	1	0
OR52E4	390081	broad.mit.edu	37	11	5905527	5905527	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:5905527C>A	uc010qzs.1	+	1	5	c.5C>A	c.(4-6)CCT>CAT	p.P2H	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	2	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P2S(1)		ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGAGAATGCCTTCTATCAAT	0.423			NA											58	194					4.66136e-34	7.06005e-34	0.00361	1	0
OR56A4	120793	broad.mit.edu	37	11	6023494	6023494	+	Silent	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:6023494C>A	uc010qzv.1	-	1	885	c.885G>T	c.(883-885)ACG>ACT	p.T295T		NM_001005179	NP_001005179	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGAACCACACGTGCTCAAGG	0.488			NA											34	54					1.62957e-23	2.25299e-23	0.00874	1	0
OR2AG1	144125	broad.mit.edu	37	11	6807144	6807144	+	Silent	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:6807144G>A	uc001mer.1	+	1	876	c.876G>A	c.(874-876)CTG>CTA	p.L292L		NM_001004489	NP_001004489	Q9H205	O2AG1_HUMAN	olfactory receptor, family 2, subfamily AG,	292	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.19e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TCTACAGCCTGAGGAATAAGG	0.512			NA											5	109					0	0	0.00308	0	0
OR5P3	120066	broad.mit.edu	37	11	7846682	7846682	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:7846682C>A	uc010rbg.1	-	1	838	c.838G>T	c.(838-840)GTG>TTG	p.V280L		NM_153445	NP_703146	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GGAATCACCACGGTGTAGAAC	0.453			NA											27	119					8.88839e-20	1.18305e-19	0.002096	1	0
TEAD1	7003	broad.mit.edu	37	11	12785743	12785743	+	Translation_Start_Site	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:12785743G>T	uc001mkj.3	+	3	584	c.-81G>T	c.(-83--79)AAGGC>AATGC			NM_021961	NP_068780	P28347	TEAD1_HUMAN	TEA domain family member 1						hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0				Epithelial(150;0.00223)|BRCA - Breast invasive adenocarcinoma(625;0.236)		TTCTTGAAAAGGCTCCAGGCT	0.463			NA											25	29					2.70662e-09	3.1285e-09	0.009535	1	0
COPB1	1315	broad.mit.edu	37	11	14496111	14496111	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:14496111G>A	uc001mli.2	-	14	1974	c.1667C>T	c.(1666-1668)TCC>TTC	p.S556F	COPB1_uc001mlg.2_Missense_Mutation_p.S556F|COPB1_uc001mlh.2_Missense_Mutation_p.S556F	NM_016451	NP_057535	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	556					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			ovary(1)|central_nervous_system(1)	2						TGTGGCAAGGGAGGCAGCAAC	0.403			NA											47	213					0	0	0.00361	0	0
GTF2H1	2965	broad.mit.edu	37	11	18380137	18380137	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:18380137C>T	uc001moi.2	+	14	2111	c.1417C>T	c.(1417-1419)CGA>TGA	p.R473*	GTF2H1_uc001moh.2_Nonsense_Mutation_p.R473*|GTF2H1_uc009yhm.2_Nonsense_Mutation_p.R357*|GTF2H1_uc001moj.2_Nonsense_Mutation_p.R161*	NM_001142307	NP_001135779	P32780	TF2H1_HUMAN	general transcription factor IIH, polypeptide 1,	473					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding				0						AGAACTTCTACGACATTTCTG	0.398			NA						NER					45	140					0	0	0.00361	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18956125	18956125	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:18956125G>T	uc001mpg.2	-	1	425	c.207C>A	c.(205-207)GCC>GCA	p.A69A		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	69	Helical; Name=2; (Potential).				acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						AGTCTGCTGCGGCCAAGTTGA	0.532			NA											71	300					6.03386e-27	8.54921e-27	0.00361	1	0
TCP11L1	55346	broad.mit.edu	37	11	33076262	33076262	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:33076262C>T	uc001mud.2	+	3	687	c.287C>T	c.(286-288)CCA>CTA	p.P96L	TCP11L1_uc009yju.2_5'UTR|TCP11L1_uc010rei.1_Missense_Mutation_p.P96L|TCP11L1_uc001mue.2_Missense_Mutation_p.P96L	NM_018393	NP_060863	Q9NUJ3	T11L1_HUMAN	t-complex 11 (mouse) like 1	96											0						GTTGAATTACCAGAAAACAGG	0.373			NA											20	114					0	0	0.00333	0	0
F2	2147	broad.mit.edu	37	11	46760614	46760614	+	Silent	SNP	A	A	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:46760614A>G	uc001ndf.3	+	13	1714	c.1671A>G	c.(1669-1671)GAA>GAG	p.E557E	F2_uc001ndg.3_RNA	NM_000506	NP_000497	P00734	THRB_HUMAN	coagulation factor II preproprotein	557	High affinity receptor-binding region which is also known as the TP508 peptide.|Peptidase S1.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity			ovary(3)	3		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	AGCCTGATGAAGGGAAACGAG	0.552	Esophageal Squamous(147;1147 1808 2148 38609 51144)		NA											6	148					0	0	0.001984	0	0
LOC440040	440040	broad.mit.edu	37	11	49830150	49830150	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:49830150C>T	uc010rhy.1	+	6	1468	c.990C>T	c.(988-990)CCC>CCT	p.P330P	LOC440040_uc009ymb.2_Silent_p.P330P	NR_027044				SubName: Full=cDNA FLJ60249, highly similar to Metabotropic glutamate receptor 5;												0						GTGCAGGGCCCATCACTGGAC	0.483			NA											10	16					0	0	0.00245	0	0
OR4C13	283092	broad.mit.edu	37	11	49974394	49974394	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:49974394C>T	uc010rhz.1	+	1	420	c.420C>T	c.(418-420)AGC>AGT	p.S140S		NM_001001955	NP_001001955	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C,	140	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						ATGTTTGTAGCCTGCTAGTGG	0.468			NA											136	144					0	0	0.00361	0	0
OR4C13	283092	broad.mit.edu	37	11	49974893	49974893	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:49974893A>T	uc010rhz.1	+	1	919	c.919A>T	c.(919-921)AGT>TGT	p.S307C		NM_001001955	NP_001001955	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C,	307	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						AGCTATTTCAAGTGTCAAATA	0.368			NA											12	52					0	0	0.003163	0	0
OR4C46	119749	broad.mit.edu	37	11	51515672	51515672	+	Missense_Mutation	SNP	A	A	G	rs140334906		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:51515672A>G	uc010ric.1	+	1	391	c.391A>G	c.(391-393)ATG>GTG	p.M131V		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTTGCACTATATGACTATCAT	0.478			NA											180	192					0	0	0.00361	0	0
TRIM48	79097	broad.mit.edu	37	11	55032517	55032517	+	Silent	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:55032517C>A	uc010rid.1	+	2	272	c.186C>A	c.(184-186)ATC>ATA	p.I62I		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	46	RING-type.					intracellular	zinc ion binding				0						GGCAAGACATCCCAATTCTTA	0.458			NA											21	77					3.83957e-06	4.20805e-06	0.00278	1	0
OR4C15	81309	broad.mit.edu	37	11	55322592	55322592	+	Silent	SNP	C	C	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:55322592C>G	uc010rig.1	+	1	810	c.810C>G	c.(808-810)TCC>TCG	p.S270S		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGCTTGTCTCCTATGCTGTCA	0.468			NA								HNSCC(20;0.049)			271	398					0	0	0.00361	0	0
OR5W2	390148	broad.mit.edu	37	11	55681287	55681287	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:55681287T>A	uc010rir.1	-	1	772	c.772A>T	c.(772-774)ATG>TTG	p.M258L		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	258	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CGGAAATACATAAAGAGCAGA	0.438	Melanoma(48;171 1190 15239 43886 49348)		NA											23	81					0	0	0.007291	0	0
OR5F1	338674	broad.mit.edu	37	11	55761338	55761338	+	Missense_Mutation	SNP	C	C	G	rs58625186	byFrequency	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:55761338C>G	uc010riv.1	-	1	764	c.764G>C	c.(763-765)TGC>TCC	p.C255S		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	255	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					AGTATAGATGCAGGTGGCATA	0.488			NA											85	127					0	0	0.00361	0	0
OR8J1	219477	broad.mit.edu	37	11	56128658	56128658	+	Silent	SNP	C	C	T	rs148720229		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:56128658C>T	uc010rjh.1	+	1	936	c.936C>T	c.(934-936)TCC>TCT	p.S312S		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	312	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TGTGCTATTCCTTTAAAACAA	0.353			NA											41	54					0	0	0.002852	0	0
OR5AP2	338675	broad.mit.edu	37	11	56409890	56409890	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:56409890C>A	uc001njb.1	-	1	26	c.26G>T	c.(25-27)GGC>GTC	p.G9V		NM_001002925	NP_001002925	Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4						TTGATTTCTGCCTCGAACCTC	0.368			NA											34	67					4.14481e-20	5.54259e-20	0.00623	1	0
OR10W1	81341	broad.mit.edu	37	11	58034994	58034994	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:58034994G>T	uc001nmq.1	-	1	739	c.337C>A	c.(337-339)CGC>AGC	p.R113S		NM_207374	NP_997257	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W,	113	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				GCCACATAGCGGTCATAGGCC	0.532			NA											69	90					7.79919e-48	1.2797e-47	0.00361	1	0
MS4A10	341116	broad.mit.edu	37	11	60558557	60558557	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:60558557G>T	uc001npz.1	+	3	390	c.294G>T	c.(292-294)GGG>GGT	p.G98G		NM_206893	NP_996776	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member	98	Helical; (Potential).					integral to membrane	receptor activity			ovary(1)|skin(1)	2						CATTCTGGGGGGCTGCCTCTG	0.582			NA											31	56					1.68508e-10	1.98388e-10	0.009718	1	0
PRPF19	27339	broad.mit.edu	37	11	60666746	60666746	+	Missense_Mutation	SNP	T	T	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:60666746T>G	uc001nqf.2	-	11	1066	c.859A>C	c.(859-861)ACT>CCT	p.T287P		NM_014502	NP_055317	Q9UMS4	PRP19_HUMAN	PRP19/PSO4 pre-mRNA processing factor 19	287	WD 2.				DNA repair|protein polyubiquitination|spliceosome assembly	catalytic step 2 spliceosome|nuclear speck|spindle|ubiquitin ligase complex	DNA binding|identical protein binding|ubiquitin-ubiquitin ligase activity			ovary(1)	1						ATCCTGATAGTGGCATCGGGG	0.488			NA									OREG0020994	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	56					0	0	0.001984	0	0
DAGLA	747	broad.mit.edu	37	11	61504654	61504654	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:61504654G>T	uc001nsa.2	+	14	1483	c.1372G>T	c.(1372-1374)GGC>TGC	p.G458C		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	458	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		CGGTCTCCAGGGCCGCGGAAC	0.637			NA											10	20					2.27111e-07	2.54775e-07	0.001368	1	0
PPP2R5B	5526	broad.mit.edu	37	11	64699039	64699039	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:64699039G>T	uc001oby.2	+	10	1539	c.954G>T	c.(952-954)CGG>CGT	p.R318R	PPP2R5B_uc001obz.2_Silent_p.R318R	NM_006244	NP_006235	Q15173	2A5B_HUMAN	beta isoform of regulatory subunit B56, protein	318					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(2)	2						AGGTGATCCGGGGGCTGCTCA	0.597			NA											8	12					0.000978159	0.00102108	0.000978	1	0
ODZ4	26011	broad.mit.edu	37	11	78412653	78412653	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:78412653C>A	uc001ozl.3	-	28	5468	c.5005G>T	c.(5005-5007)GAG>TAG	p.E1669*	ODZ4_uc009yvb.1_Nonsense_Mutation_p.E253*	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1669	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						ATGGCCAACTCGTGTCCTTGT	0.507			NA											14	65					9.16793e-09	1.04908e-08	0.00499	1	0
FAM181B	220382	broad.mit.edu	37	11	82444630	82444630	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:82444630C>T	uc001ozp.2	-	1	277	c.142G>A	c.(142-144)GGT>AGT	p.G48S		NM_175885	NP_787081	A6NEQ2	F181B_HUMAN	hypothetical protein LOC220382	48										large_intestine(1)	1						AGCAGCGCACCCGCCGGAGCC	0.692			NA											3	6					0	0	0.001984	0	0
GRM5	2915	broad.mit.edu	37	11	88780774	88780774	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:88780774G>T	uc001pcq.2	-	1	467	c.267C>A	c.(265-267)ATC>ATA	p.I89I	GRM5_uc009yvm.2_Silent_p.I89I|GRM5_uc009yvn.1_Silent_p.I89I	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	89	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AGCCCAGTGTGATGTTGGGCA	0.527			NA											15	16					0.000132079	0.000140441	0.008871	1	0
CHORDC1	26973	broad.mit.edu	37	11	89947211	89947211	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:89947211G>T	uc001pdg.2	-	4	714	c.304C>A	c.(304-306)CCA>ACA	p.P102T	CHORDC1_uc009yvz.2_Missense_Mutation_p.P83T	NM_012124	NP_036256	Q9UHD1	CHRD1_HUMAN	cysteine and histidine-rich domain-containing	102	Interaction with HSP90AA1 and HSP90AB1 (By similarity).				chaperone-mediated protein folding|regulation of response to stress|response to stress		Hsp90 protein binding|identical protein binding				0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.00915)				GCTTCTACTGGCTTAGGGGCT	0.383			NA											24	67					1.17739e-12	1.44269e-12	0.005443	1	0
PANX1	24145	broad.mit.edu	37	11	93862607	93862607	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:93862607G>T	uc001per.2	+	1	514	c.129G>T	c.(127-129)GTG>GTT	p.V43V	uc001pen.1_5'Flank|PANX1_uc001peq.2_Silent_p.V43V	NM_015368	NP_056183	Q96RD7	PANX1_HUMAN	pannexin 1	43	Helical; (Potential).				positive regulation of interleukin-1 beta secretion|protein hexamerization|synaptic transmission	bleb|endoplasmic reticulum membrane|gap junction|integral to membrane	calcium channel activity|gap junction hemi-channel activity|leak channel activity|receptor binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GCATTGCGGTGGGGCTGCCCC	0.647			NA											5	13					0.00621372	0.00640439	0.006214	1	0
MAML2	84441	broad.mit.edu	37	11	95825768	95825768	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:95825768C>A	uc001pfw.1	-	2	2712	c.1427G>T	c.(1426-1428)GGG>GTG	p.G476V		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	476					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				TTTCTCCTGCCCAAATGGACC	0.517			NA	T	MECT1|CRTC3	salivary gland mucoepidermoid								37	62					1.32136e-16	1.68414e-16	0.00874	1	0
TRPC6	7225	broad.mit.edu	37	11	101359765	101359765	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:101359765C>T	uc001pgk.3	-	4	1621	c.1196G>A	c.(1195-1197)CGA>CAA	p.R399Q	TRPC6_uc009ywy.2_Intron|TRPC6_uc009ywz.1_Intron	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	399	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TGTCTGCTGTCGTAAACCAGA	0.448	Colon(166;1315 1927 11094 12848 34731)		NA											9	34					0	0	0.003163	0	0
KIAA1377	57562	broad.mit.edu	37	11	101793446	101793446	+	Missense_Mutation	SNP	G	G	T	rs142032267		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:101793446G>T	uc001pgm.2	+	2	473	c.203G>T	c.(202-204)CGA>CTA	p.R68L	KIAA1377_uc001pgn.2_Missense_Mutation_p.R24L	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	68	Potential.						protein binding	p.R68*(1)		breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		AAAATATGTCGAAATCGAGCA	0.303			NA											6	11					0.00116845	0.00121527	0.001168	1	0
MMP1	4312	broad.mit.edu	37	11	102666324	102666324	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:102666324G>T	uc001phi.2	-	5	783	c.640C>A	c.(640-642)CGT>AGT	p.R214S	uc001phh.1_Intron|MMP1_uc010ruv.1_Missense_Mutation_p.R148S	NM_002421	NP_002412	P03956	MMP1_HUMAN	matrix metalloproteinase 1 isoform 1	214	Metalloprotease.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)|lung(1)	4	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		GCTGCAACACGATGTAAGTTG	0.368			NA											11	45					6.31663e-08	7.14217e-08	0.003163	1	0
DDI1	414301	broad.mit.edu	37	11	103908205	103908205	+	Silent	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:103908205C>A	uc001phr.2	+	1	898	c.655C>A	c.(655-657)CGG>AGG	p.R219R	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	219					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		AGAGGAAATCCGGCAGCAAAA	0.483			NA											20	32					7.33628e-21	9.90311e-21	0.002299	1	0
FAM55B	120406	broad.mit.edu	37	11	114568908	114568908	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:114568908G>C	uc009yyy.2	+	3	372	c.274G>C	c.(274-276)GAC>CAC	p.D92H		NM_182495	NP_872301	Q96DL1	FA55B_HUMAN	hypothetical protein LOC120406	92						integral to membrane				ovary(1)	1						GGAGAAACTAGACCAGCAGAT	0.458			NA											48	160					0	0	0.00361	0	0
SIK3	23387	broad.mit.edu	37	11	116728895	116728895	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:116728895G>A	uc001ppy.2	-	20	3004	c.2968C>T	c.(2968-2970)CAA>TAA	p.Q990*	SIK3_uc001ppz.2_Nonsense_Mutation_p.Q829*|SIK3_uc001pqa.2_Nonsense_Mutation_p.Q930*|SIK3_uc001ppw.2_Nonsense_Mutation_p.Q347*|SIK3_uc001ppx.2_Nonsense_Mutation_p.Q368*|SIK3_uc001pqb.2_Nonsense_Mutation_p.Q293*	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	990						cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						TCAGCATTTTGATAAGATAAA	0.552			NA											9	37					0	0	0.008291	0	0
ROBO4	54538	broad.mit.edu	37	11	124754802	124754802	+	Silent	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:124754802A>T	uc001qbg.2	-	18	3149	c.3009T>A	c.(3007-3009)CCT>CCA	p.P1003P	ROBO4_uc010sas.1_Silent_p.P858P	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	1003					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		AGTAATCTACAGGAGAAGCTG	0.557			NA											18	58					0	0	0.00278	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128839021	128839021	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:128839021G>T	uc009zcp.2	-	22	6045	c.6045C>A	c.(6043-6045)AGC>AGA	p.S2015R	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Missense_Mutation_p.S974R|ARHGAP32_uc001qez.2_Missense_Mutation_p.S1666R	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	2015	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						CAGTCACACTGCTCTGGCGCT	0.562			NA											18	34					8.34094e-07	9.3021e-07	0.008871	1	0
CACNA2D4	93589	broad.mit.edu	37	12	1953620	1953620	+	Silent	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:1953620T>A	uc001qjp.2	-	25	2649	c.2418A>T	c.(2416-2418)TCA>TCT	p.S806S	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Silent_p.S670S|CACNA2D4_uc009zdr.1_RNA	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	806	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CAGGATGCTCTGAGGCCTGGC	0.632	Colon(2;101 179 21030 23310 28141)		NA											14	22					0	0	0.007413	0	0
SCNN1A	6337	broad.mit.edu	37	12	6463650	6463650	+	Silent	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:6463650C>A	uc001qnx.2	-	8	1603	c.1314G>T	c.(1312-1314)CGG>CGT	p.R438R	SCNN1A_uc001qnv.2_Silent_p.R138R|SCNN1A_uc001qnw.2_Silent_p.R497R|SCNN1A_uc010sfb.1_Silent_p.R461R	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	438	Extracellular (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	CGTTCTGGGGCCGCGGATAGA	0.587			NA											21	16					1.16021e-09	1.34924e-09	0.007291	1	0
TAS2R9	50835	broad.mit.edu	37	12	10962482	10962482	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:10962482C>G	uc001qyx.2	-	1	286	c.193G>C	c.(193-195)GAT>CAT	p.D65H	TAS2R8_uc010shh.1_5'Flank	NM_023917	NP_076406	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	65	Helical; Name=2; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						AAGAAGCCATCTAATGATATT	0.413			NA											145	210					0	0	0.00361	0	0
SOX5	6660	broad.mit.edu	37	12	23689448	23689448	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:23689448C>T	uc001rfw.2	-	14	2029	c.1927G>A	c.(1927-1929)GGT>AGT	p.G643S	SOX5_uc001rfx.2_Missense_Mutation_p.G630S|SOX5_uc001rfy.2_Missense_Mutation_p.G522S|SOX5_uc001rfv.2_Missense_Mutation_p.G257S|SOX5_uc010siv.1_Missense_Mutation_p.G630S|SOX5_uc010siw.1_RNA	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	643					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						TTGTATTCACCAATGCGCAGC	0.507			NA											39	80					0	0	0.002522	0	0
OVCH1	341350	broad.mit.edu	37	12	29624753	29624753	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:29624753G>A	uc001rix.1	-	16	1838	c.1838C>T	c.(1837-1839)GCA>GTA	p.A613V		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	613	Peptidase S1 2.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					ACAGTGGGCTGCGGTCAGAAT	0.488			NA											37	53					0	0	0.009718	0	0
IPO8	10526	broad.mit.edu	37	12	30837254	30837254	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:30837254G>T	uc001rjd.2	-	3	474	c.304C>A	c.(304-306)CGG>AGG	p.R102R		NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	102	Importin N-terminal.				intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					TCTGGAGACCGAATTATTCCT	0.418			NA											97	195					8.73416e-63	1.50671e-62	0.00361	1	0
IPO8	10526	broad.mit.edu	37	12	30843467	30843467	+	Silent	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:30843467T>A	uc001rjd.2	-	2	299	c.129A>T	c.(127-129)ATA>ATT	p.I43I		NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	43	Importin N-terminal.				intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					GGTCAGAGACTATAATCCGAA	0.328			NA											63	65					0	0	0.00361	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43895977	43895977	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:43895977T>C	uc010skx.1	-	4	845	c.845A>G	c.(844-846)TAT>TGT	p.Y282C		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	282	Peptidase M12B.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AGTCAGTATATAGTTTTGCAA	0.279			NA											10	15					0	0	0.000978	0	0
MLL2	8085	broad.mit.edu	37	12	49448739	49448739	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:49448739C>A	uc001rta.3	-	2	120	c.120G>T	c.(118-120)GAG>GAT	p.E40D		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	40					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGACAGAGACCTCTCCCACAT	0.532			NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			163	232					1.02705e-64	1.7825e-64	0.00361	1	0
XPOT	11260	broad.mit.edu	37	12	64819617	64819617	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:64819617G>T	uc001ssb.2	+	15	2021	c.1595G>T	c.(1594-1596)GGT>GTT	p.G532V		NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	532	Necessary for tRNA-binding, cytoplasmic localization and nuclear export.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		GATCACAGAGGTCTGCGGCAT	0.373			NA											62	169					1.10345e-40	1.75998e-40	0.00361	1	0
MSRB3	253827	broad.mit.edu	37	12	65857034	65857034	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:65857034A>T	uc001ssn.2	+	6	572	c.511A>T	c.(511-513)AGC>TGC	p.S171C	MSRB3_uc001ssm.2_Missense_Mutation_p.S164C|MSRB3_uc009zqp.2_Missense_Mutation_p.S164C	NM_198080	NP_932346	Q8IXL7	MSRB3_HUMAN	methionine sulfoxide reductase B3 isoform 1	171					protein repair	endoplasmic reticulum|mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.131)		ACCTGCGGATAGCAGTGGCAC	0.547			NA											29	60					0	0	0.002852	0	0
TRHDE	29953	broad.mit.edu	37	12	72680664	72680664	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:72680664C>T	uc001sxa.2	+	2	1013	c.983C>T	c.(982-984)TCC>TTC	p.S328F		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	328	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CCTCTCATGTCCACATATTAT	0.398			NA											46	94					0	0	0.00361	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85546113	85546113	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:85546113C>T	uc001tac.2	+	20	4496	c.4385C>T	c.(4384-4386)ACA>ATA	p.T1462I		NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1462										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		CCTTCACAAACACTGCTTCTT	0.393			NA											40	95					0	0	0.00361	0	0
UHRF1BP1L	23074	broad.mit.edu	37	12	100444041	100444041	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:100444041C>A	uc001tgq.2	-	17	3852	c.3623G>T	c.(3622-3624)GGG>GTG	p.G1208V	UHRF1BP1L_uc001tgp.2_Missense_Mutation_p.G858V	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	1208										ovary(2)	2						TGTATCTTCCCCTCGGATGTC	0.388			NA											17	49					4.7796e-09	5.51344e-09	0.004656	1	0
NR1H4	9971	broad.mit.edu	37	12	100926360	100926360	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:100926360G>A	uc001tht.1	+	3	628	c.600G>A	c.(598-600)ATG>ATA	p.M200I	NR1H4_uc001thp.1_Missense_Mutation_p.M190I|NR1H4_uc001thq.1_Missense_Mutation_p.M190I|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Missense_Mutation_p.M190I|NR1H4_uc010svk.1_Intron|NR1H4_uc001ths.1_Missense_Mutation_p.M200I	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	200	Nuclear receptor.				bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						GCAAAGAGATGGGAATGTTGG	0.403			NA											9	279					0	0	0.008291	0	0
NR1H4	9971	broad.mit.edu	37	12	100926373	100926373	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:100926373G>A	uc001tht.1	+	3	641	c.613G>A	c.(613-615)GAA>AAA	p.E205K	NR1H4_uc001thp.1_Missense_Mutation_p.E195K|NR1H4_uc001thq.1_Missense_Mutation_p.E195K|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Missense_Mutation_p.E195K|NR1H4_uc010svk.1_Intron|NR1H4_uc001ths.1_Missense_Mutation_p.E205K	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	205	Nuclear receptor.				bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						AATGTTGGCTGAATGTATGTA	0.408			NA											7	259					0	0	0.004482	0	0
SLC5A8	160728	broad.mit.edu	37	12	101573854	101573854	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:101573854A>T	uc001thz.3	-	10	1576	c.1186T>A	c.(1186-1188)TGT>AGT	p.C396S		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	396	Helical; (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						ATTCCAATACACAGGGCTCCA	0.433	GBM(60;420 1056 13605 22380 47675)		NA											157	289					0	0	0.00361	0	0
GNPTAB	79158	broad.mit.edu	37	12	102183810	102183810	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:102183810C>T	uc001tit.2	-	3	408	c.229G>A	c.(229-231)GTT>ATT	p.V77I	GNPTAB_uc001tiu.1_Missense_Mutation_p.V77I	NM_024312	NP_077288	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase	77					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			ovary(1)|skin(1)	2						GTGTAAACAACGTCAATCGGC	0.428			NA											178	386					0	0	0.00361	0	0
CKAP4	10970	broad.mit.edu	37	12	106633077	106633077	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:106633077T>A	uc001tlk.2	-	2	1618	c.1534A>T	c.(1534-1536)ACG>TCG	p.T512S		NM_006825	NP_006816	Q07065	CKAP4_HUMAN	cytoskeleton-associated protein 4	512						ER-Golgi intermediate compartment membrane|integral to membrane|membrane fraction					0						CTGAGCAGCGTGTGCACCTGC	0.607			NA											19	27					0	0	0.002299	0	0
SELPLG	6404	broad.mit.edu	37	12	109017819	109017819	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:109017819G>C	uc001tni.2	-	2	425	c.265C>G	c.(265-267)CGT>GGT	p.R89G	SELPLG_uc001tnh.2_Missense_Mutation_p.R89G|SELPLG_uc010sxe.1_Missense_Mutation_p.R105G	NM_003006	NP_002997	Q14242	SELPL_HUMAN	selectin P ligand	89	Extracellular (Potential).				blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding				0						CCAGTAGAACGCCTTGCAGCA	0.582			NA											20	48					0	0	0.003954	0	0
CCDC63	160762	broad.mit.edu	37	12	111321993	111321993	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:111321993C>A	uc001trv.1	+	8	1208	c.1013C>A	c.(1012-1014)ACG>AAG	p.T338K	CCDC63_uc010sye.1_Missense_Mutation_p.T298K|CCDC63_uc001trw.1_Missense_Mutation_p.T253K	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	338										skin(6)|ovary(1)|pancreas(1)	8						GCTCGGTTCACGTATGTCACG	0.562			NA											49	114					5.47352e-35	8.42421e-35	0.00361	1	0
C12orf51	283450	broad.mit.edu	37	12	112744003	112744003	+	Silent	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:112744003G>A	uc009zwc.2	-	1	36	c.18C>T	c.(16-18)CTC>CTT	p.L6L		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						TGCCAATGGGGAGGTGATTGG	0.498			NA											28	30					0	0	0.006999	0	0
SRRM4	84530	broad.mit.edu	37	12	119554754	119554754	+	Nonsense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:119554754T>A	uc001txa.1	+	4	670	c.378T>A	c.(376-378)TAT>TAA	p.Y126*		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	126	Ser-rich.|Lys-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						CCTCATCCTATAGCCCATCGC	0.473			NA											11	45					0	0	0.003163	0	0
PRKAB1	5564	broad.mit.edu	37	12	120112183	120112183	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:120112183C>T	uc009zwu.2	+	5	559	c.456C>T	c.(454-456)ATC>ATT	p.I152I	PRKAB1_uc001txg.2_Silent_p.I152I	NM_006253	NP_006244	Q9Y478	AAKB1_HUMAN	AMP-activated protein kinase beta 1	152					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol					0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.166)	Adenosine monophosphate(DB00131)|Metformin(DB00331)	TTAACAACATCATTCAAGTGA	0.418			NA											5	88					0	0	0.006214	0	0
PRKAB1	5564	broad.mit.edu	37	12	120112187	120112187	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:120112187C>T	uc009zwu.2	+	5	563	c.460C>T	c.(460-462)CAA>TAA	p.Q154*	PRKAB1_uc001txg.2_Nonsense_Mutation_p.Q154*	NM_006253	NP_006244	Q9Y478	AAKB1_HUMAN	AMP-activated protein kinase beta 1	154					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol					0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.166)	Adenosine monophosphate(DB00131)|Metformin(DB00331)	CAACATCATTCAAGTGAAGAA	0.413			NA											7	92					0	0	0.008291	0	0
DNAH10	196385	broad.mit.edu	37	12	124297768	124297768	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:124297768G>T	uc001uft.3	+	19	2873	c.2848G>T	c.(2848-2850)GAA>TAA	p.E950*	DNAH10_uc010tav.1_Nonsense_Mutation_p.E492*|DNAH10_uc010taw.1_Nonsense_Mutation_p.E435*	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	950	Stem (By similarity).|Poly-Glu.				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GAAGGGGGAGGAAGAGGAAGT	0.393			NA											49	85					7.34454e-26	1.0304e-25	0.00361	1	0
TMEM132D	121256	broad.mit.edu	37	12	130185209	130185209	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:130185209C>A	uc009zyl.1	-	2	442	c.114G>T	c.(112-114)CAG>CAT	p.Q38H		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	38	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		AGGAAAACCTCTGGATGCTCT	0.502			NA											36	26					3.4597e-24	4.81827e-24	0.00361	1	0
PIWIL1	9271	broad.mit.edu	37	12	130839524	130839524	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:130839524G>T	uc001uik.2	+	11	1353	c.1263G>T	c.(1261-1263)GTG>GTT	p.V421V	PIWIL1_uc001uij.1_Silent_p.V421V	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	421					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		AGCGTGAAGTGGGACGACTCA	0.378			NA											156	275					9.2415e-74	1.61868e-73	0.00361	1	0
SACS	26278	broad.mit.edu	37	13	23909782	23909782	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr13:23909782C>A	uc001uon.2	-	10	8822	c.8233G>T	c.(8233-8235)GAA>TAA	p.E2745*	SACS_uc001uoo.2_Nonsense_Mutation_p.E2598*|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	2745					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GAAATTTTTTCCATGTGATTA	0.383			NA											26	44					8.24728e-16	1.04186e-15	0.004656	1	0
ATP12A	479	broad.mit.edu	37	13	25264583	25264583	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr13:25264583C>T	uc001upp.2	+	6	841	c.654C>T	c.(652-654)ATC>ATT	p.I218I	ATP12A_uc010aaa.2_Silent_p.I218I	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	218	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CTGCAGACATCAGGGTGCTGT	0.572	Pancreas(156;1582 1935 18898 22665 26498)		NA											15	132					0	0	0.003954	0	0
AKAP11	11215	broad.mit.edu	37	13	42891710	42891710	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr13:42891710G>A	uc001uys.1	+	12	5626	c.5451G>A	c.(5449-5451)ATG>ATA	p.M1817I		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1817					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		ATATTGACATGGAGCCATGCA	0.373			NA											8	155					0	0	0.006214	0	0
DACH1	1602	broad.mit.edu	37	13	72255996	72255996	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr13:72255996G>C	uc010thn.1	-	3	1318	c.895C>G	c.(895-897)CCA>GCA	p.P299A	DACH1_uc010tho.1_Missense_Mutation_p.P299A|DACH1_uc010thp.1_Missense_Mutation_p.P299A	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	299	Interaction with SIX6 and HDAC3 (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		GAGTTCTCTGGGGAGGTGACA	0.418			NA											57	41					0	0	0.00361	0	0
ITGBL1	9358	broad.mit.edu	37	13	102367973	102367973	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr13:102367973G>T	uc001vpb.2	+	11	1673	c.1454G>T	c.(1453-1455)TGT>TTT	p.C485F	ITGBL1_uc010agb.2_Missense_Mutation_p.C436F|ITGBL1_uc001vpc.3_Missense_Mutation_p.C344F	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat	485	X.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GGAAATGCATGTGAAATCTGG	0.373			NA											180	141					3.54448e-97	6.32468e-97	0.00361	1	0
OR4E2	26686	broad.mit.edu	37	14	22133768	22133768	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:22133768G>T	uc010tmd.1	+	1	472	c.472G>T	c.(472-474)GGG>TGG	p.G158W		NM_001001912	NP_001001912	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		TCACTCACTAGGGCAGACCTT	0.488			NA											204	210					5.12032e-141	9.40097e-141	0.00361	1	0
CMA1	1215	broad.mit.edu	37	14	24974789	24974789	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:24974789G>T	uc001wpp.1	-	5	707	c.677C>A	c.(676-678)CCC>CAC	p.P226H	CMA1_uc010alx.1_Missense_Mutation_p.P115H	NM_001836	NP_001827	P23946	CMA1_HUMAN	chymase 1, mast cell preproprotein	226	Peptidase S1.				interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.0271)		GACAGCAGGGGGCTTTGCATC	0.587			NA											56	47					1.41257e-51	2.3379e-51	0.00361	1	0
ARHGAP5	394	broad.mit.edu	37	14	32562466	32562466	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:32562466G>T	uc001wrl.2	+	2	2830	c.2591G>T	c.(2590-2592)GGA>GTA	p.G864V	ARHGAP5_uc001wrm.2_Missense_Mutation_p.G864V|ARHGAP5_uc001wrn.2_Missense_Mutation_p.G864V|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	864					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		GCTTCGATGGGAATGCTTCGA	0.383	NSCLC(9;77 350 3443 29227 41353)		NA											15	109					3.51602e-12	4.27159e-12	0.008871	1	0
KIAA0391	9692	broad.mit.edu	37	14	35596743	35596743	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:35596743T>A	uc001wsy.1	+	4	1453	c.1093T>A	c.(1093-1095)TAT>AAT	p.Y365N	KIAA0391_uc010tps.1_Missense_Mutation_p.Y270N|KIAA0391_uc001wsz.1_Missense_Mutation_p.Y349N|KIAA0391_uc001wta.2_RNA|KIAA0391_uc001wtb.1_Missense_Mutation_p.Y349N|KIAA0391_uc001wtc.1_5'UTR	NM_014672	NP_055487	O15091	MRRP3_HUMAN	mitochondrial RNase P protein 3 precursor	365					tRNA processing	mitochondrion					0	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		TCCAGAAGAATATGAATGTCT	0.358			NA											41	187					0	0	0.002852	0	0
FAM179B	23116	broad.mit.edu	37	14	45513851	45513851	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:45513851G>T	uc001wvv.2	+	13	4141	c.3932G>T	c.(3931-3933)CGT>CTT	p.R1311L	FAM179B_uc001wvw.2_Missense_Mutation_p.R1311L|FAM179B_uc010anc.2_RNA	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	1311							binding			skin(2)|upper_aerodigestive_tract(1)	3						AAAAATTTACGTTCTGGAGTT	0.308			NA											15	26					3.41278e-10	3.99324e-10	0.00499	1	0
BMP4	652	broad.mit.edu	37	14	54417449	54417449	+	Silent	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:54417449G>A	uc001xal.3	-	3	715	c.528C>T	c.(526-528)CAC>CAT	p.H176H	BMP4_uc010aoh.2_Silent_p.H176H|BMP4_uc001xao.3_Silent_p.H176H|BMP4_uc001xan.3_Silent_p.H176H	NM_130851	NP_570912	P12644	BMP4_HUMAN	bone morphogenetic protein 4 preproprotein	176					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity				0						TGTTTATACGGTGGAAGCCCC	0.562			NA											5	25					0	0	0.001168	0	0
KTN1	3895	broad.mit.edu	37	14	56122831	56122831	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:56122831G>C	uc001xcb.2	+	30	3175	c.2873G>C	c.(2872-2874)AGC>ACC	p.S958T	KTN1_uc001xce.2_Missense_Mutation_p.S958T|KTN1_uc001xcc.2_Missense_Mutation_p.S958T|KTN1_uc001xcd.2_Missense_Mutation_p.S935T|KTN1_uc010trb.1_Missense_Mutation_p.S958T|KTN1_uc001xcf.1_Missense_Mutation_p.S935T|KTN1_uc010aoq.2_Missense_Mutation_p.S253T	NM_182926	NP_891556	Q86UP2	KTN1_HUMAN	kinectin 1 isoform a	958	Lumenal (Potential).|Potential.				microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7						GATCTTTCTAGCAAAACACAG	0.303			NA	T	RET	papillary thryoid								14	45					0	0	0.004007	0	0
PLEKHH1	57475	broad.mit.edu	37	14	68029127	68029127	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:68029127G>T	uc001xjl.1	+	7	921	c.779G>T	c.(778-780)GGA>GTA	p.G260V		NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	260						cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		CCTCATCTGGGAAGAGAGAGC	0.542			NA											24	37					1.71298e-08	1.95232e-08	0.003755	1	0
STON2	85439	broad.mit.edu	37	14	81837395	81837395	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:81837395C>G	uc010tvu.1	-	3	709	c.508G>C	c.(508-510)GAT>CAT	p.D170H	STON2_uc001xvk.1_Missense_Mutation_p.D170H	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	170					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		AGCTGCAGATCTGTATACGAA	0.532			NA											58	182					0	0	0.00361	0	0
SLC24A4	123041	broad.mit.edu	37	14	92959901	92959901	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:92959901T>A	uc001yak.2	+	17	1771	c.1747T>A	c.(1747-1749)TGC>AGC	p.C583S	SLC24A4_uc001yai.2_Missense_Mutation_p.C536S|SLC24A4_uc010twm.1_Missense_Mutation_p.C581S|SLC24A4_uc001yaj.2_Missense_Mutation_p.C564S|SLC24A4_uc010auj.2_3'UTR|SLC24A4_uc010twn.1_Missense_Mutation_p.C356S|SLC24A4_uc001yan.2_Missense_Mutation_p.C294S	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	600	Helical; (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		CATCTTCTTGTGCTTCTCCAT	0.552	NSCLC(10;315 435 10383 28450 38798)		NA											12	34					0	0	0.001855	0	0
C14orf177	283598	broad.mit.edu	37	14	99182659	99182659	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:99182659C>T	uc001yfz.1	+	3	550	c.131C>T	c.(130-132)TCT>TTT	p.S44F		NM_182560	NP_872366	Q52M58	CN177_HUMAN	hypothetical protein LOC283598	44											0		Melanoma(154;0.128)				TGCCCAAGTTCTCAGCACCTG	0.532			NA											48	81					0	0	0.00361	0	0
C14orf177	283598	broad.mit.edu	37	14	99182700	99182700	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:99182700C>A	uc001yfz.1	+	3	591	c.172C>A	c.(172-174)CTG>ATG	p.L58M		NM_182560	NP_872366	Q52M58	CN177_HUMAN	hypothetical protein LOC283598	58											0		Melanoma(154;0.128)				GCAGCATGCCCTGACGCTCAC	0.473			NA											18	93					7.45023e-12	8.97485e-12	0.010504	1	0
SLC12A1	6557	broad.mit.edu	37	15	48500154	48500154	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:48500154G>T	uc001zwn.3	+	2	454	c.238G>T	c.(238-240)GCT>TCT	p.A80S	SLC12A1_uc010uew.1_Intron|SLC12A1_uc010bem.2_Missense_Mutation_p.A80S|SLC12A1_uc010uex.1_Missense_Mutation_p.A80S	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	80	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	TGGAGAAACTGCTAAAACAGA	0.428			NA											21	57					3.7963e-18	4.93779e-18	0.00333	1	0
DMXL2	23312	broad.mit.edu	37	15	51829946	51829946	+	Silent	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:51829946C>A	uc002abf.2	-	11	1581	c.1356G>T	c.(1354-1356)CTG>CTT	p.L452L	DMXL2_uc010ufy.1_Silent_p.L452L|DMXL2_uc010bfa.2_Silent_p.L452L	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	452						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		ATTCTCTATCCAGGGATAAAT	0.338			NA											47	94					3.57465e-26	5.0274e-26	0.00361	1	0
KIAA1370	56204	broad.mit.edu	37	15	52902041	52902041	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:52902041C>A	uc002acg.3	-	6	1223	c.1070G>T	c.(1069-1071)GGT>GTT	p.G357V	KIAA1370_uc002ach.3_RNA|KIAA1370_uc010bfg.1_Missense_Mutation_p.G269V|KIAA1370_uc010ugf.1_Missense_Mutation_p.G364V	NM_019600	NP_062546	Q32MH5	K1370_HUMAN	hypothetical protein LOC56204	357											0				all cancers(107;0.0803)		GTTAGTCTCACCAGCTGACTG	0.388			NA											11	15					1.3612e-06	1.51215e-06	0.003163	1	0
MAP2K1	5604	broad.mit.edu	37	15	66727455	66727455	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:66727455G>T	uc010bhq.2	+	2	646	c.171G>T	c.(169-171)AAG>AAT	p.K57N	MAP2K1_uc010ujp.1_Missense_Mutation_p.K35N	NM_002755	NP_002746	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	57					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						TTACCCAGAAGCAGAAGGTGG	0.542			NA							Cardiofaciocutaneous_syndrome				133	428					1.13329e-80	1.99724e-80	0.00361	1	0
ITGA11	22801	broad.mit.edu	37	15	68596108	68596108	+	Splice_Site	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:68596108A>T	uc002ari.2	-	29	3582	c.3495_splice	c.e29+1	p.K1165_splice	ITGA11_uc010bib.2_Splice_Site_p.K1166_splice	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor						cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	CAGGGCCCTCACCTTCCACAG	0.662			NA											16	35					0	0	0.010504	0	0
NOX5	79400	broad.mit.edu	37	15	69335109	69335109	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:69335109G>C	uc002ars.1	+	10	1631	c.1611G>C	c.(1609-1611)AGG>AGC	p.R537S	NOX5_uc002arp.1_Missense_Mutation_p.R519S|NOX5_uc002arq.1_Missense_Mutation_p.R491S|NOX5_uc010bid.1_Missense_Mutation_p.R502S|NOX5_uc002arr.1_Missense_Mutation_p.R509S|NOX5_uc010bie.1_Missense_Mutation_p.R337S|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	537	FAD-binding FR-type.|Cytoplasmic (Potential).|C-terminal catalytic region.				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						GGCTGTCGAGGAGTGTGACAA	0.557			NA											24	271					0	0	0.002096	0	0
MYO9A	4649	broad.mit.edu	37	15	72197314	72197314	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:72197314G>A	uc002atl.3	-	20	3192	c.2719C>T	c.(2719-2721)CAA>TAA	p.Q907*	MYO9A_uc010biq.2_Nonsense_Mutation_p.Q527*|MYO9A_uc002atn.1_Nonsense_Mutation_p.Q888*	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	907	Actin-binding (By similarity).|Myosin head-like 2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						GGTTCTGCTTGACCAAGTGTT	0.328			NA											27	607					0	0	0.005524	0	0
LOC645752	645752	broad.mit.edu	37	15	78211427	78211427	+	Missense_Mutation	SNP	G	G	T	rs71145882		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:78211427G>T	uc010bky.2	-	11	1104	c.340C>A	c.(340-342)CTC>ATC	p.L114I		NR_027024				SubName: Full=GOLGA6 protein; Flags: Fragment;												0						TGCTCTCGGAGCATCTCCTCC	0.587			NA											14	26					3.51602e-12	4.27159e-12	0.008871	1	0
AP3B2	8120	broad.mit.edu	37	15	83349659	83349659	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:83349659C>T	uc010uoh.1	-	7	878	c.701G>A	c.(700-702)TGG>TAG	p.W234*	AP3B2_uc010uoi.1_Nonsense_Mutation_p.W234*|AP3B2_uc010uoj.1_Nonsense_Mutation_p.W202*|AP3B2_uc010uog.1_5'Flank	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	234					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			CACCTGGCCCCACTCCTCCAC	0.612			NA											5	28					0	0	0.001168	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84651595	84651595	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:84651595C>A	uc002bjz.3	+	21	3439	c.3215C>A	c.(3214-3216)TCC>TAC	p.S1072Y	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.S1072Y|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.S1072Y	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1072						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGCACCAACTCCTGGGAGTTG	0.433			NA											82	123					7.22319e-40	1.14568e-39	0.00361	1	0
WDR93	56964	broad.mit.edu	37	15	90245192	90245192	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:90245192G>T	uc002boj.2	+	2	316	c.215G>T	c.(214-216)TGG>TTG	p.W72L	WDR93_uc002bok.3_Missense_Mutation_p.W72L|WDR93_uc010bnr.2_Missense_Mutation_p.W72L	NM_020212	NP_064597	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	72					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			ovary(2)	2	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			GACCAGTCTTGGGAAATTATT	0.502			NA											42	59					9.39024e-22	1.28273e-21	0.009718	1	0
ARRDC4	91947	broad.mit.edu	37	15	98512352	98512352	+	Splice_Site	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:98512352G>T	uc010bom.2	+	5	785	c.626_splice	c.e5-1	p.G209_splice	ARRDC4_uc002bui.3_Splice_Site_p.G122_splice	NM_183376	NP_899232	Q8NCT1	ARRD4_HUMAN	arrestin domain containing 4						signal transduction						0	Melanoma(26;0.00539)|Lung NSC(78;0.0125)|all_lung(78;0.0222)		OV - Ovarian serous cystadenocarcinoma(32;0.0417)			TTTCTTTTTAGGAGAAGCTAT	0.393			NA											9	18					5.50884e-06	6.00295e-06	0.001368	1	0
LRRK1	79705	broad.mit.edu	37	15	101597252	101597252	+	Silent	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:101597252G>A	uc002bwr.2	+	28	4843	c.4524G>A	c.(4522-4524)GAG>GAA	p.E1508E	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bws.2_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1508	Protein kinase.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CTAAGCCAGAGAAGGTACTTG	0.647			NA											10	20					0	0	0.008291	0	0
OR4F6	390648	broad.mit.edu	37	15	102346241	102346241	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:102346241G>T	uc010utr.1	+	1	319	c.319G>T	c.(319-321)GTT>TTT	p.V107F		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	107	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TATCCATGCAGTTGGGGGAAC	0.473			NA											147	659					3.69633e-99	6.61632e-99	0.00361	1	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:102515299G>A	uc002cdi.2	+	9	1943	c.523G>A	c.(523-525)GGC>AGC	p.G175S	WASH3P_uc002cdl.2_Missense_Mutation_p.G175S|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.G175S|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						TGGGGGCATCGGCAAGGCCAA	0.652			NA											2	3					0	0	0.009096	0	0
ZG16B	124220	broad.mit.edu	37	16	2881957	2881957	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:2881957T>A	uc002cru.2	+	4	500	c.424T>A	c.(424-426)TAT>AAT	p.Y142N		NM_145252	NP_660295	Q96DA0	ZG16B_HUMAN	zymogen granule protein 16 homolog B precursor	142						extracellular region	sugar binding			ovary(1)	1						CAAGGACCGCTATTTCTATTT	0.542			NA											8	13					0	0	0.008291	0	0
UBN1	29855	broad.mit.edu	37	16	4924652	4924652	+	Silent	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:4924652G>A	uc002cyb.2	+	15	2580	c.2241G>A	c.(2239-2241)GGG>GGA	p.G747G	UBN1_uc010uxw.1_Silent_p.G747G|UBN1_uc002cyc.2_Silent_p.G747G	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	747					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						TGGCACTGGGGCAGTCCTCTC	0.527			NA											35	98					0	0	0.009718	0	0
GRIN2A	2903	broad.mit.edu	37	16	9943739	9943739	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:9943739G>T	uc002czo.3	-	5	1750	c.1202C>A	c.(1201-1203)CCG>CAG	p.P401Q	GRIN2A_uc010uym.1_Missense_Mutation_p.P401Q|GRIN2A_uc010uyn.1_Missense_Mutation_p.P244Q|GRIN2A_uc002czr.3_Missense_Mutation_p.P401Q	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	401	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GTTGTCATCCGGCTCACAGTC	0.587			NA											73	154					2.9056e-39	4.59584e-39	0.00361	1	0
CLEC16A	23274	broad.mit.edu	37	16	11219945	11219945	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:11219945G>T	uc002dao.2	+	22	2813	c.2583G>T	c.(2581-2583)CGG>CGT	p.R861R	CLEC16A_uc002dan.3_Silent_p.R843R|CLEC16A_uc002dap.2_5'UTR	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	861										ovary(1)|central_nervous_system(1)	2						AGGGGCGCCGGGGCAGCAGCG	0.657			NA											10	25					5.01169e-05	5.37909e-05	0.00499	1	0
XYLT1	64131	broad.mit.edu	37	16	17221646	17221646	+	Silent	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:17221646G>A	uc002dfa.2	-	10	2185	c.2100C>T	c.(2098-2100)ATC>ATT	p.I700I		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	700	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						CATGATGCTTGATCAGAAAGC	0.517			NA											60	195					0	0	0.00361	0	0
XYLT1	64131	broad.mit.edu	37	16	17221699	17221699	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:17221699G>T	uc002dfa.2	-	10	2132	c.2047C>A	c.(2047-2049)CCA>ACA	p.P683T		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	683	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						ACAGATGCTGGGTGGCCCATT	0.527			NA											82	81					1.63847e-34	2.49484e-34	0.00361	1	0
XYLT1	64131	broad.mit.edu	37	16	17228362	17228362	+	Silent	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:17228362C>A	uc002dfa.2	-	9	2080	c.1995G>T	c.(1993-1995)ACG>ACT	p.T665T		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	665	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						TGTGCAGGGACGTCTCGGCCC	0.607			NA											13	52					5.26018e-13	6.48717e-13	0.001882	1	0
POLR3E	55718	broad.mit.edu	37	16	22325425	22325425	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:22325425G>T	uc002dkk.2	+	8	654	c.498G>T	c.(496-498)GCG>GCT	p.A166A	POLR3E_uc002dkj.1_Silent_p.A166A|POLR3E_uc002dkm.2_Silent_p.A130A|POLR3E_uc010vbr.1_Silent_p.A166A|POLR3E_uc002dkl.2_Silent_p.A166A|POLR3E_uc010vbs.1_Silent_p.A130A|POLR3E_uc010vbt.1_Silent_p.A110A	NM_018119	NP_060589	Q9NVU0	RPC5_HUMAN	RNA polymerase III polypeptide E	166					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.012)		AGGATGAGGCGGAAGACGATG	0.637			NA											8	17					0.00010058	0.000107148	0.001368	1	0
CLN3	1201	broad.mit.edu	37	16	28498827	28498827	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:28498827C>T	uc002dpo.2	-	6	733	c.410G>A	c.(409-411)GGA>GAA	p.G137E	uc010vct.1_Intron|CLN3_uc002dpl.2_Missense_Mutation_p.G59E|CLN3_uc010vcu.1_Missense_Mutation_p.G37E|CLN3_uc002dpn.2_Nonsense_Mutation_p.W110*|CLN3_uc002dpm.2_Missense_Mutation_p.G83E|CLN3_uc010vcv.1_Missense_Mutation_p.G113E|CLN3_uc010byd.2_Missense_Mutation_p.G137E|CLN3_uc002dpp.2_Missense_Mutation_p.G137E|CLN3_uc002dpt.1_Missense_Mutation_p.G37E|CLN3_uc002dpq.1_Missense_Mutation_p.G137E|CLN3_uc010bye.1_Missense_Mutation_p.G137E|CLN3_uc002dpr.1_RNA|CLN3_uc010byf.1_RNA|CLN3_uc002dps.1_Nonsense_Mutation_p.W82*|CLN3_uc002dpu.1_Missense_Mutation_p.G83E|CLN3_uc002dpw.1_Nonsense_Mutation_p.W56*|CLN3_uc010vcw.1_Missense_Mutation_p.G83E|CLN3_uc002dqa.2_Missense_Mutation_p.G188E|CLN3_uc010vcx.1_Missense_Mutation_p.G37E|CLN3_uc002dpx.1_Nonsense_Mutation_p.W86*|CLN3_uc002dpy.1_Nonsense_Mutation_p.W53*|CLN3_uc002dpz.1_RNA	NM_000086	NP_000077	Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	137	Helical; (Potential).				amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0						GACGAAGCTTCCAGCAGCACA	0.592			NA											8	33					0	0	0.008291	0	0
ATXN2L	11273	broad.mit.edu	37	16	28844674	28844674	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:28844674G>C	uc002drc.2	+	14	2122	c.1954G>C	c.(1954-1956)GAA>CAA	p.E652Q	uc010vct.1_Intron|ATXN2L_uc010byl.1_3'UTR|ATXN2L_uc002drb.2_Missense_Mutation_p.E652Q|ATXN2L_uc002dqy.2_Missense_Mutation_p.E652Q|ATXN2L_uc002dra.2_Missense_Mutation_p.E652Q|ATXN2L_uc002dqz.2_Missense_Mutation_p.E652Q|ATXN2L_uc010vdb.1_Missense_Mutation_p.E658Q|ATXN2L_uc002dre.2_Missense_Mutation_p.E652Q|ATXN2L_uc002drf.2_Missense_Mutation_p.E61Q|ATXN2L_uc002drg.2_5'Flank	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	652						membrane				upper_aerodigestive_tract(1)|ovary(1)	2						CCCTGTTGCTGAGTGAGTGGA	0.577			NA											12	19					0	0	0.004007	0	0
SALL1	6299	broad.mit.edu	37	16	51172949	51172949	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:51172949C>T	uc010vgs.1	-	2	3215	c.3184G>A	c.(3184-3186)GAG>AAG	p.E1062K	SALL1_uc010vgr.1_Missense_Mutation_p.E965K|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	1062					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GAACTGGGCTCAAAGAGCTGG	0.488	GBM(103;1352 1446 1855 4775 8890)		NA											3	44					0	0	0.009096	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53726179	53726179	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:53726179C>G	uc002ehp.2	-	4	392	c.328G>C	c.(328-330)GAA>CAA	p.E110Q	RPGRIP1L_uc002eho.3_Missense_Mutation_p.E110Q|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.E110Q|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.E110Q|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.E110Q|RPGRIP1L_uc002ehq.1_Missense_Mutation_p.E110Q	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	110	Potential.				negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				TCAATCATTTCTTCCATTTCC	0.448			NA											15	106					0	0	0.007413	0	0
MLKL	197259	broad.mit.edu	37	16	74708939	74708939	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:74708939C>A	uc002fdb.2	-	10	1741	c.1300G>T	c.(1300-1302)GGT>TGT	p.G434C	MLKL_uc002fdc.2_Missense_Mutation_p.G226C	NM_152649	NP_689862	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like isoform 1	434	Protein kinase.						ATP binding|protein binding|protein kinase activity			stomach(2)	2						CAGTCTTCACCCAGTGGCTCC	0.552			NA											9	40					1.15919e-05	1.25836e-05	0.008871	1	0
PLCG2	5336	broad.mit.edu	37	16	81957157	81957157	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:81957157G>T	uc002fgt.2	+	22	2527	c.2375G>T	c.(2374-2376)CGT>CTT	p.R792L		NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	792	SH3.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						AGCTTCTGCCGTGGTGCCCTC	0.567			NA											21	24					3.73988e-18	4.87551e-18	0.00632	1	0
MTHFSD	64779	broad.mit.edu	37	16	86582165	86582165	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:86582165C>A	uc002fjn.2	-	4	307	c.256G>T	c.(256-258)GTT>TTT	p.V86F	MTHFSD_uc010voo.1_Missense_Mutation_p.V66F|MTHFSD_uc002fjo.2_5'UTR|MTHFSD_uc002fjm.2_Missense_Mutation_p.V85F|MTHFSD_uc010vop.1_5'UTR|MTHFSD_uc010voq.1_Missense_Mutation_p.V85F|MTHFSD_uc010vor.1_Missense_Mutation_p.V86F|MTHFSD_uc002fjp.2_Missense_Mutation_p.V66F	NM_001159377	NP_001152849	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain	86					folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding				0						GGTGTTGGAACCAACAATGTT	0.358			NA											9	34					0.00829132	0.008515	0.008291	1	0
OR1A1	8383	broad.mit.edu	37	17	3119135	3119135	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:3119135C>A	uc010vrc.1	+	1	221	c.221C>A	c.(220-222)TCA>TAA	p.S74*		NM_014565	NP_055380	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A,	74	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATCTTCTTCTCATCGGTAACC	0.483			NA											300	413					1.11038e-139	2.02564e-139	0.00361	1	0
SHPK	23729	broad.mit.edu	37	17	3514090	3514090	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:3514090C>A	uc002fvz.1	-	7	1304	c.1201G>T	c.(1201-1203)GCT>TCT	p.A401S	TRPV1_uc010vru.1_5'Flank	NM_013276	NP_037408	Q9UHJ6	SHPK_HUMAN	carbohydrate kinase-like	401					carbohydrate metabolic process	cytoplasm	ATP binding|sedoheptulokinase activity			ovary(1)	1				COAD - Colon adenocarcinoma(5;0.0828)		CGGCACAGAGCCCGGGTCACG	0.647			NA											8	44					0.00829132	0.008515	0.008291	1	0
C17orf81	23587	broad.mit.edu	37	17	7160226	7160226	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:7160226G>A	uc002gfg.1	+	6	615	c.508G>A	c.(508-510)GAG>AAG	p.E170K	C17orf81_uc002gfj.2_Missense_Mutation_p.E170K|C17orf81_uc010cmb.2_Missense_Mutation_p.E170K|C17orf81_uc002gfh.1_Missense_Mutation_p.E170K|C17orf81_uc002gfi.1_Missense_Mutation_p.E170K|C17orf81_uc002gfl.1_Missense_Mutation_p.E170K	NM_203415	NP_981960	Q8TE02	DERP6_HUMAN	S-phase 2 protein isoform 4	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding				0						GCTACATGAAGAGCTTCATGG	0.582			NA											6	50					0	0	0.006214	0	0
TP53	7157	broad.mit.edu	37	17	7578177	7578177	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:7578177C>A	uc002gim.2	-	6	866	c.672G>T	c.(670-672)GAG>GAT	p.E224D	TP53_uc002gig.1_Missense_Mutation_p.E224D|TP53_uc002gih.2_Missense_Mutation_p.E224D|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E92D|TP53_uc010cng.1_Missense_Mutation_p.E92D|TP53_uc002gii.1_Missense_Mutation_p.E92D|TP53_uc010cnh.1_Missense_Mutation_p.E224D|TP53_uc010cni.1_Missense_Mutation_p.E224D|TP53_uc002gij.2_Missense_Mutation_p.E224D|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.E131D|TP53_uc002gio.2_Missense_Mutation_p.E92D|TP53_uc010vug.1_Missense_Mutation_p.E185D	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	224	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> V (in a sporadic cancer; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E224D(11)|p.0?(7)|p.E224E(6)|p.E224K(5)|p.E224*(4)|p.?(3)|p.E224G(2)|p.E224fs*4(1)|p.E224fs*5(1)|p.V218_E224delVPYEPPE(1)|p.E224fs*23(1)|p.V225fs*24(1)|p.E224fs*24(1)|p.E224_V225insXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAAACCAGACCTCAGGCGGCT	0.522	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			31	31					6.29468e-14	7.83064e-14	0.004878	1	0
WDR16	146845	broad.mit.edu	37	17	9546400	9546400	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:9546400G>A	uc002gly.2	+	14	1817	c.1748G>A	c.(1747-1749)GGG>GAG	p.G583E	USP43_uc002gma.3_5'Flank|USP43_uc010cod.2_5'Flank|USP43_uc010vva.1_5'Flank|WDR16_uc002glz.2_Missense_Mutation_p.G515E|WDR16_uc010coc.2_Missense_Mutation_p.G593E	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	583						cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						ACTCACGTTGGGGTGGGACAC	0.443			NA											5	57					0	0	0.000602	0	0
SLFN13	146857	broad.mit.edu	37	17	33767735	33767735	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:33767735G>A	uc002hjk.1	-	4	2903	c.2573C>T	c.(2572-2574)TCA>TTA	p.S858L	SLFN13_uc010wch.1_Missense_Mutation_p.S858L|SLFN13_uc002hjl.2_Missense_Mutation_p.S858L|SLFN13_uc010ctt.2_Missense_Mutation_p.S540L|SLFN13_uc002hjm.2_Missense_Mutation_p.S527L	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	858						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TTCCAGGCCTGAGAATCGCCG	0.488			NA											8	232					0	0	0.00308	0	0
ZPBP2	124626	broad.mit.edu	37	17	38033026	38033026	+	Silent	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:38033026A>T	uc002hte.2	+	8	1134	c.981A>T	c.(979-981)CCA>CCT	p.P327P	ZPBP2_uc002htf.2_Silent_p.P305P	NM_199321	NP_955353	Q6X784	ZPBP2_HUMAN	zona pellucida binding protein 2 isoform 2	327					binding of sperm to zona pellucida	extracellular region				ovary(1)	1	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)			AATCTTGCCCACAAACTTCAA	0.418			NA											47	156					0	0	0.00361	0	0
KRTAP4-4	84616	broad.mit.edu	37	17	39316831	39316831	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:39316831G>T	uc002hwc.2	-	1	153	c.113C>A	c.(112-114)CCC>CAC	p.P38H		NM_032524	NP_115913	Q9BYR3	KRA44_HUMAN	keratin associated protein 4.4	38	26 X 5 AA repeats of C-C-[GRQVCH]-[SPT]- [VSTQR].|4.					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			ACAGCAGCTGGGGCGGCAGCA	0.652			NA											40	59					3.76287e-55	6.37566e-55	0.00361	1	0
STAT3	6774	broad.mit.edu	37	17	40483494	40483494	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:40483494C>T	uc002hzl.1	-	11	1345	c.1105G>A	c.(1105-1107)GAC>AAC	p.D369N	STAT3_uc002hzk.1_Missense_Mutation_p.D369N|STAT3_uc002hzm.1_Missense_Mutation_p.D369N|STAT3_uc010wgh.1_Missense_Mutation_p.D271N|STAT3_uc002hzn.1_Missense_Mutation_p.D369N	NM_139276	NP_644805	P40763	STAT3_HUMAN	signal transducer and activator of transcription	369					cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		ACTTACTTGTCAATGCACACT	0.323			NA							Hyperimmunoglobulin_E_Recurrent_Infection_Syndrome				4	22					0	0	0.009096	0	0
MYL4	4635	broad.mit.edu	37	17	45299121	45299121	+	Silent	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:45299121G>A	uc002ilg.2	+	5	515	c.387G>A	c.(385-387)CAG>CAA	p.Q129Q	MYL4_uc002ilh.2_Silent_p.Q129Q	NM_001002841	NP_001002841	P12829	MYL4_HUMAN	atrial/embryonic alkali myosin light chain	129					cardiac muscle contraction|muscle filament sliding|muscle organ development|positive regulation of ATPase activity|regulation of the force of heart contraction	A band|cytosol|muscle myosin complex	actin filament binding|actin monomer binding|calcium ion binding|myosin II heavy chain binding|structural constituent of muscle			ovary(2)	2						ACAAGGAGCAGGGCACCTATG	0.557			NA											5	126					0	0	0.001168	0	0
SCRN2	90507	broad.mit.edu	37	17	45915657	45915657	+	Silent	SNP	C	C	T	rs147761976	byFrequency	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:45915657C>T	uc002imd.2	-	7	1224	c.1098G>A	c.(1096-1098)CTG>CTA	p.L366L	SCRN2_uc002imc.2_Silent_p.L374L|SCRN2_uc002imf.2_Silent_p.L366L|SCRN2_uc002ime.2_RNA	NM_138355	NP_612364	Q96FV2	SCRN2_HUMAN	secernin 2 isoform 1	366					proteolysis		dipeptidase activity			ovary(1)	1						CCATCAGCCCCAGGGCTGCCT	0.592			NA											3	29					0	0	0.009096	0	0
OR4D2	124538	broad.mit.edu	37	17	56247349	56247349	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:56247349G>C	uc010wnp.1	+	1	333	c.333G>C	c.(331-333)ATG>ATC	p.M111I		NM_001004707	NP_001004707	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D,	111	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						GAGGTGCCATGGTCTTCTTCC	0.547			NA											85	51					0	0	0.00361	0	0
BCAS3	54828	broad.mit.edu	37	17	59161869	59161869	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:59161869C>T	uc002iyv.3	+	23	2523	c.2414C>T	c.(2413-2415)TCA>TTA	p.S805L	BCAS3_uc002iyu.3_Missense_Mutation_p.S790L|BCAS3_uc002iyw.3_Missense_Mutation_p.S786L|BCAS3_uc002iyy.3_Missense_Mutation_p.S561L|BCAS3_uc002iyz.3_Missense_Mutation_p.S359L|BCAS3_uc002iza.3_Missense_Mutation_p.S344L	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	805						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			ATGCCAGGGTCATCCCGTCCA	0.473			NA											21	82					0	0	0.002096	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62856639	62856639	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:62856639G>T	uc002jey.2	-	11	4156	c.3625C>A	c.(3625-3627)CCA>ACA	p.P1209T	LRRC37A3_uc010wqg.1_Missense_Mutation_p.P327T|LRRC37A3_uc002jex.1_Missense_Mutation_p.P186T|LRRC37A3_uc010wqf.1_Missense_Mutation_p.P247T|LRRC37A3_uc010dek.1_Missense_Mutation_p.P215T	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1209	Extracellular (Potential).					integral to membrane					0						CTTGGGGCTGGACTTCCGAGC	0.552			NA											26	14					3.76114e-14	4.6891e-14	0.004289	1	0
OTOP3	347741	broad.mit.edu	37	17	72938029	72938029	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:72938029G>T	uc010wrr.1	+	3	524	c.524G>T	c.(523-525)TGC>TTC	p.C175F	OTOP3_uc010wrq.1_Missense_Mutation_p.C157F	NM_178233	NP_839947	Q7RTS5	OTOP3_HUMAN	otopetrin 3	175	Helical; (Potential).					integral to membrane|intracellular	zinc ion binding			ovary(1)	1	all_lung(278;0.151)|Lung NSC(278;0.185)					TGCACCTTCTGCCTCAACATC	0.622			NA											24	14					8.88839e-20	1.18305e-19	0.002096	1	0
TNRC6C	57690	broad.mit.edu	37	17	76045357	76045357	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:76045357G>A	uc002jud.2	+	4	814	c.214G>A	c.(214-216)GGA>AGA	p.G72R	TNRC6C_uc002juf.2_Missense_Mutation_p.G72R|TNRC6C_uc002jue.2_Missense_Mutation_p.G72R	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	72	Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			TGGTGGGGATGGAAAAATGGA	0.522			NA											13	116					0	0	0.003163	0	0
TNRC6C	57690	broad.mit.edu	37	17	76061008	76061008	+	Silent	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:76061008G>A	uc002jud.2	+	5	3201	c.2601G>A	c.(2599-2601)CTG>CTA	p.L867L	TNRC6C_uc002juf.2_Silent_p.L864L|TNRC6C_uc002jue.2_Silent_p.L864L	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	867	Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			CCTCAGCCCTGTGCAAACCAG	0.532			NA											6	3					0	0	0.001168	0	0
CBX2	84733	broad.mit.edu	37	17	77757733	77757733	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:77757733G>T	uc002jxc.2	+	5	533	c.491G>T	c.(490-492)CGG>CTG	p.R164L		NM_005189	NP_005180	Q14781	CBX2_HUMAN	chromobox homolog 2 isoform 1	164	Nuclear localization signal (Potential).				cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CGGAAGAAGCGGGGACGAAAG	0.677			NA											4	1					1.06961e-07	1.20463e-07	0.00308	1	0
RNF213	57674	broad.mit.edu	37	17	78343442	78343442	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:78343442A>G	uc002jyh.1	+	20	6738	c.6515A>G	c.(6514-6516)CAA>CGA	p.Q2172R	uc002jyi.1_Intron|RNF213_uc010dhw.1_Missense_Mutation_p.Q554R	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CTCTTCGTCCAAAAGGGGCGC	0.502			NA											3	47					0	0	0.004672	0	0
SECTM1	6398	broad.mit.edu	37	17	80280050	80280050	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:80280050G>C	uc002keo.2	-	5	1132	c.734C>G	c.(733-735)GCC>GGC	p.A245G	SECTM1_uc002ken.2_Missense_Mutation_p.A243G|SECTM1_uc002kep.2_3'UTR	NM_003004	NP_002995	Q8WVN6	SCTM1_HUMAN	secreted and transmembrane 1 precursor	245	Cytoplasmic (Potential).				immune response|mesoderm development|positive regulation of I-kappaB kinase/NF-kappaB cascade	extracellular space|Golgi apparatus|integral to membrane|plasma membrane	cytokine activity|signal transducer activity				0	Breast(20;0.000675)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.249)		OV - Ovarian serous cystadenocarcinoma(97;0.00928)|BRCA - Breast invasive adenocarcinoma(99;0.0833)			TGGGTCTGCGGCATATGGAAA	0.657			NA											6	2					0	0	0.006214	0	0
DLGAP1	9229	broad.mit.edu	37	18	3742422	3742422	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr18:3742422G>T	uc002kmf.2	-	3	1330	c.1263C>A	c.(1261-1263)GAC>GAA	p.D421E	DLGAP1_uc010wyz.1_Missense_Mutation_p.D421E|DLGAP1_uc002kme.1_Missense_Mutation_p.D119E|DLGAP1_uc010dkn.2_Missense_Mutation_p.D119E|DLGAP1_uc010wyw.1_Missense_Mutation_p.D127E|DLGAP1_uc010wyx.1_Missense_Mutation_p.D133E|DLGAP1_uc010wyy.1_Missense_Mutation_p.D133E|DLGAP1_uc002kmg.2_Missense_Mutation_p.D119E|DLGAP1_uc002kmk.2_Missense_Mutation_p.D421E	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	421					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				GGTCCAGGCTGTCCAGGCTCC	0.557			NA											4	8					5.18039e-06	5.66667e-06	0.00308	1	0
FAM38B	63895	broad.mit.edu	37	18	10671622	10671622	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr18:10671622C>A	uc002kor.3	-	14	2172	c.2032G>T	c.(2032-2034)GGA>TGA	p.G678*	FAM38B_uc002koq.2_Nonsense_Mutation_p.G513*	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2721						integral to membrane	ion channel activity			ovary(1)	1						TCCAGTTCTCCTGTCTCTCGA	0.363			NA											19	51					7.41877e-09	8.52338e-09	0.001882	1	0
FAM38B	63895	broad.mit.edu	37	18	10672688	10672688	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr18:10672688C>T	uc002kor.3	-	13	2016	c.1876G>A	c.(1876-1878)GGT>AGT	p.G626S	FAM38B_uc002koq.2_Missense_Mutation_p.G461S	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2669	Helical; (Potential).					integral to membrane	ion channel activity			ovary(1)	1						AGTCCTTACCCATAGCCAGCC	0.438			NA											6	127					0	0	0.00308	0	0
FAM38B	63895	broad.mit.edu	37	18	10672706	10672706	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr18:10672706C>T	uc002kor.3	-	13	1998	c.1858G>A	c.(1858-1860)GGG>AGG	p.G620R	FAM38B_uc002koq.2_Missense_Mutation_p.G455R	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2663	Helical; (Potential).					integral to membrane	ion channel activity			ovary(1)	1						GCCAGGAACCCCAGACTTGGG	0.463			NA											8	139					0	0	0.006214	0	0
ZNF519	162655	broad.mit.edu	37	18	14105896	14105896	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr18:14105896C>A	uc002kst.1	-	3	796	c.643G>T	c.(643-645)GGT>TGT	p.G215C	ZNF519_uc002ksq.1_Intron|ZNF519_uc002ksr.1_Intron|ZNF519_uc010dlm.1_Intron	NM_145287	NP_660330	Q8TB69	ZN519_HUMAN	zinc finger protein 519	215					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAAGTTTCACCACATTCATTA	0.299			NA											38	86					3.37043e-27	4.78735e-27	0.00361	1	0
CDH2	1000	broad.mit.edu	37	18	25562988	25562988	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr18:25562988G>A	uc002kwg.2	-	14	2728	c.2269C>T	c.(2269-2271)CAA>TAA	p.Q757*	CDH2_uc010xbn.1_Nonsense_Mutation_p.Q726*	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	757	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						ATTAAAAGTTGTTTGGCCTGG	0.353			NA											42	143					0	0	0.00361	0	0
ASXL3	80816	broad.mit.edu	37	18	31325156	31325156	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr18:31325156C>A	uc010dmg.1	+	12	5399	c.5344C>A	c.(5344-5346)CTT>ATT	p.L1782I	ASXL3_uc002kxq.2_Missense_Mutation_p.L1489I	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1782					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TCCATTGCCTCTTCAAACTAC	0.507			NA											25	71					3.17567e-06	3.49385e-06	0.008361	1	0
CXXC1	30827	broad.mit.edu	37	18	47810186	47810186	+	Splice_Site	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr18:47810186C>T	uc002leq.3	-	11	2147	c.1414_splice	c.e11-1	p.S472_splice	MBD1_uc002leg.2_5'Flank|MBD1_uc010dow.1_5'Flank|MBD1_uc010xdi.1_5'Flank|MBD1_uc002leh.3_5'Flank|MBD1_uc002len.2_5'Flank|MBD1_uc002lei.3_5'Flank|MBD1_uc002lej.3_5'Flank|MBD1_uc002lek.3_5'Flank|MBD1_uc002lel.3_5'Flank|MBD1_uc002lem.3_5'Flank|MBD1_uc010xdj.1_5'Flank|MBD1_uc010xdk.1_5'Flank|MBD1_uc002leo.2_5'Flank|CXXC1_uc002lep.3_Splice_Site_p.S329_splice|CXXC1_uc002ler.3_Splice_Site_p.S476_splice|CXXC1_uc010doy.2_Splice_Site_p.S472_splice	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2						histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CCTCGTTGCTCTGCATGGAAT	0.577			NA											27	429					0	0	0.00361	0	0
TCF4	6925	broad.mit.edu	37	18	52896212	52896212	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr18:52896212C>A	uc002lfz.2	-	18	2345	c.1733G>T	c.(1732-1734)CGT>CTT	p.R578L	TCF4_uc002lfw.3_Missense_Mutation_p.R422L|TCF4_uc010xdu.1_Missense_Mutation_p.R448L|TCF4_uc010xdv.1_Missense_Mutation_p.R448L|TCF4_uc002lfx.2_Missense_Mutation_p.R511L|TCF4_uc010xdw.1_Missense_Mutation_p.R448L|TCF4_uc002lfy.2_Missense_Mutation_p.R536L|TCF4_uc010xdx.1_Missense_Mutation_p.R554L|TCF4_uc010dph.1_Missense_Mutation_p.R582L|TCF4_uc010xdy.1_Missense_Mutation_p.R558L|TCF4_uc002lga.2_Missense_Mutation_p.R684L|TCF4_uc002lgb.1_Missense_Mutation_p.R418L|TCF4_uc010dpi.2_Missense_Mutation_p.R588L|TCF4_uc002lfv.2_Missense_Mutation_p.R361L	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	578	Helix-loop-helix motif.				positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		GTTGATGTCACGGACCCGCAG	0.592			NA											109	168					1.95696e-54	3.28654e-54	0.00361	1	0
NEDD4L	23327	broad.mit.edu	37	18	56024480	56024480	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr18:56024480G>T	uc002lgy.2	+	19	2037	c.1763G>T	c.(1762-1764)GGT>GTT	p.G588V	NEDD4L_uc002lgz.2_Missense_Mutation_p.G524V|NEDD4L_uc002lgx.2_Missense_Mutation_p.G568V|NEDD4L_uc010xee.1_Missense_Mutation_p.G467V|NEDD4L_uc002lhc.2_Missense_Mutation_p.G580V|NEDD4L_uc002lhd.2_Missense_Mutation_p.G467V|NEDD4L_uc002lhb.2_Missense_Mutation_p.G447V|NEDD4L_uc002lhe.2_Missense_Mutation_p.G560V|NEDD4L_uc002lhf.2_Missense_Mutation_p.G447V|NEDD4L_uc002lhg.2_Missense_Mutation_p.G467V|NEDD4L_uc002lhh.2_Missense_Mutation_p.G363V|NEDD4L_uc010dpm.1_Missense_Mutation_p.G269V	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally	588					cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4						GCTATTACTGGTCCGGTCAGT	0.353			NA											68	174					1.91123e-38	2.99811e-38	0.00361	1	0
PIGN	23556	broad.mit.edu	37	18	59749964	59749964	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr18:59749964C>G	uc002lii.3	-	29	2966	c.2518G>C	c.(2518-2520)GTT>CTT	p.V840L	PIGN_uc002lij.3_Missense_Mutation_p.V840L	NM_176787	NP_789744	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	840	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5		Colorectal(73;0.187)				ATAACAAGAACAAAGGGGATT	0.299			NA											10	13					0	0	0.001855	0	0
PHLPP1	23239	broad.mit.edu	37	18	60646229	60646229	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr18:60646229G>T	uc002lis.2	+	18	3361	c.3183G>T	c.(3181-3183)CGG>CGT	p.R1061R		NM_194449	NP_919431	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein	1573					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity				0						ACTGCAGCCGGGCCAAGGAGA	0.617			NA											27	27					1.15183e-24	1.60806e-24	0.009718	1	0
SERPINB11	89778	broad.mit.edu	37	18	61387285	61387285	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr18:61387285C>T	uc002ljk.3	+	7	576	c.514C>T	c.(514-516)CCT>TCT	p.P172S	SERPINB11_uc010xes.1_5'UTR|SERPINB11_uc010dqd.2_Missense_Mutation_p.P58S|SERPINB11_uc002ljj.3_Missense_Mutation_p.P58S|SERPINB11_uc010dqe.2_Intron|SERPINB11_uc010dqf.2_Intron	NM_080475	NP_536723	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B, member 11	172					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)	1		Esophageal squamous(42;0.129)				CACAATTGACCCTTCATCTGT	0.333	Ovarian(27;496 784 5942 8975 23930)		NA											64	72					0	0	0.00361	0	0
ZADH2	284273	broad.mit.edu	37	18	72920923	72920923	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr18:72920923G>T	uc002llx.2	-	1	359	c.91C>A	c.(91-93)CAA>AAA	p.Q31K	TSHZ1_uc002lly.2_5'Flank	NM_175907	NP_787103	Q8N4Q0	ZADH2_HUMAN	zinc binding alcohol dehydrogenase domain	31						peroxisome	oxidoreductase activity|zinc ion binding				0		Esophageal squamous(42;0.131)|Prostate(75;0.155)		READ - Rectum adenocarcinoma(2;0.0276)|BRCA - Breast invasive adenocarcinoma(31;0.216)		TGCATGGCTTGGGGAATGGCG	0.716			NA											3	5					0.00024832	0.000261606	0.009096	1	0
SHC2	25759	broad.mit.edu	37	19	436212	436212	+	Silent	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:436212G>A	uc002loq.3	-	7	906	c.906C>T	c.(904-906)TTC>TTT	p.F302F	SHC2_uc002lop.3_Silent_p.F43F	NM_012435	NP_036567	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing)	302	PID.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol					0		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTACTGCTTGAAGCGCAGCT	0.657			NA											4	4					0	0	0.009096	0	0
FEM1A	55527	broad.mit.edu	37	19	4793326	4793326	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:4793326A>T	uc002mbf.2	+	1	1599	c.1460A>T	c.(1459-1461)GAC>GTC	p.D487V	uc002mbg.1_RNA	NM_018708	NP_061178	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a	487					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GAGCCCGGAGACTCAGCCCAG	0.642			NA											13	6					0	0	0.00245	0	0
MUC16	94025	broad.mit.edu	37	19	9074611	9074611	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:9074611G>T	uc002mkp.2	-	3	13039	c.12835C>A	c.(12835-12837)CAC>AAC	p.H4279N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4281	Thr-rich.|Extracellular (Potential).|Ser-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCCATGATGTGGGAGGTAACC	0.498			NA											214	80					1.3228e-122	2.38271e-122	0.00361	1	0
ZNF560	147741	broad.mit.edu	37	19	9578658	9578658	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:9578658C>A	uc002mlp.1	-	10	1175	c.965G>T	c.(964-966)TGG>TTG	p.W322L	ZNF560_uc010dwr.1_Missense_Mutation_p.W216L	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	322					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						ACATTGCTTCCATTCATTGAG	0.388			NA											80	33					6.64032e-35	1.0138e-34	0.00361	1	0
BRD4	23476	broad.mit.edu	37	19	15365073	15365073	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:15365073G>A	uc002nar.2	-	11	2270	c.2048C>T	c.(2047-2049)GCT>GTT	p.A683V	BRD4_uc002nas.2_Missense_Mutation_p.A683V|BRD4_uc002nat.3_Missense_Mutation_p.A683V	NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	683					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			AACTTTCTCAGCTGCAATCCA	0.582			NA	T	NUT|C15orf55	lethal midline carcinoma of young people								23	9					0	0	0.00632	0	0
LOC284441	284441	broad.mit.edu	37	19	20370088	20370088	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:20370088G>T	uc002nov.2	+	1	1632	c.881G>T	c.(880-882)CGC>CTC	p.R294L		NR_003128				SubName: Full=cDNA FLJ51655, highly similar to Actin-like protein 2;												0						GACCCATCCCGCAGAAAGCAC	0.413			NA											5	35					0.000602214	0.000629788	0.000602	1	0
ZNF208	7757	broad.mit.edu	37	19	22155657	22155657	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:22155657C>G	uc002nqp.2	-	5	2028	c.1879G>C	c.(1879-1881)GGC>CGC	p.G627R	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				AAGCTTTTGCCACATTCTTCA	0.378			NA											45	124					0	0	0.00361	0	0
ZNF208	7757	broad.mit.edu	37	19	22157153	22157153	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:22157153G>T	uc002nqp.2	-	4	832	c.683C>A	c.(682-684)CCC>CAC	p.P228H	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACATCTGTAGGGTTTCTCTCC	0.363			NA											62	67					9.12251e-31	1.32543e-30	0.00361	1	0
ZNF254	9534	broad.mit.edu	37	19	24309689	24309689	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:24309689G>T	uc002nru.2	+	4	1021	c.887G>T	c.(886-888)TGT>TTT	p.C296F	ZNF254_uc010xrk.1_Missense_Mutation_p.C211F	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	296	C2H2-type 4.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				CCTTACAAGTGTGAAGAATGT	0.363			NA											37	86					5.20006e-24	7.22442e-24	0.002852	1	0
LSM14A	26065	broad.mit.edu	37	19	34710724	34710724	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:34710724A>T	uc002nvb.3	+	8	1274	c.1078A>T	c.(1078-1080)AAT>TAT	p.N360Y	LSM14A_uc002nva.3_Missense_Mutation_p.N360Y|LSM14A_uc010xru.1_Missense_Mutation_p.N319Y|LSM14A_uc002nvc.3_Missense_Mutation_p.N166Y	NM_001114093	NP_001107565	Q8ND56	LS14A_HUMAN	LSM14 homolog A isoform a	360					cytoplasmic mRNA processing body assembly|multicellular organismal development|regulation of translation	cytoplasmic mRNA processing body|intracellular membrane-bounded organelle|stress granule				skin(1)	1	Esophageal squamous(110;0.162)					ACTTGGACCTAATTGCTATTA	0.348			NA											36	41					0	0	0.00874	0	0
RBM42	79171	broad.mit.edu	37	19	36120510	36120510	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:36120510G>A	uc002oan.2	+	2	293	c.217G>A	c.(217-219)GAA>AAA	p.E73K	RBM42_uc010xsx.1_Missense_Mutation_p.E73K|RBM42_uc010eef.2_Missense_Mutation_p.E73K|RBM42_uc002oao.2_Missense_Mutation_p.E73K|RBM42_uc002oap.2_Missense_Mutation_p.E73K|RBM42_uc002oaq.2_Missense_Mutation_p.E73K|RBM42_uc010eeg.2_Missense_Mutation_p.E73K	NM_024321	NP_077297	Q9BTD8	RBM42_HUMAN	RNA binding motif protein 42	73						cytoplasm|nucleus	nucleotide binding|RNA binding				0	all_lung(56;1.58e-07)|Lung NSC(56;2.43e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CCCCACAGTAGAAGCGATGCA	0.587			NA											7	89					0	0	0.004482	0	0
ZNF585B	92285	broad.mit.edu	37	19	37676497	37676497	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:37676497T>A	uc002ofq.2	-	5	2196	c.1942A>T	c.(1942-1944)AAT>TAT	p.N648Y	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Missense_Mutation_p.N462Y	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	648	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTACTGAGATTTGACCTGCCA	0.473	Melanoma(93;882 1454 18863 28917 48427)		NA											18	25					0	0	0.002096	0	0
PSMD8	5714	broad.mit.edu	37	19	38873891	38873891	+	Splice_Site	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:38873891A>T	uc002oii.3	+	7	968	c.916_splice	c.e7-2	p.R306_splice		NM_002812	NP_002803	P48556	PSMD8_HUMAN	proteasome 26S non-ATPase subunit 8						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome regulatory particle	protein binding			central_nervous_system(1)	1	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CCTTTCCTGCAGCGAGGGTGG	0.562			NA											7	11					0	0	0.006214	0	0
FAM98C	147965	broad.mit.edu	37	19	38896205	38896205	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:38896205G>T	uc002oin.1	+	6	699	c.680G>T	c.(679-681)TGC>TTC	p.C227F	FAM98C_uc002oio.1_Missense_Mutation_p.C201F|FAM98C_uc010xtz.1_Intron	NM_174905	NP_777565	Q17RN3	FA98C_HUMAN	hypothetical protein LOC147965	227										skin(1)	1	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CAGTACCGCTGCCGCCGCTGC	0.597			NA											10	14					1.58986e-06	1.76274e-06	0.008291	1	0
RYR1	6261	broad.mit.edu	37	19	38983214	38983214	+	Missense_Mutation	SNP	G	G	T	rs139775280		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:38983214G>T	uc002oit.2	+	38	6342	c.6212G>T	c.(6211-6213)CGG>CTG	p.R2071L	RYR1_uc002oiu.2_Missense_Mutation_p.R2071L	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2071	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GAGAAAGTGCGGCTGGTGAAG	0.592			NA											8	10					6.72482e-11	7.96654e-11	0.003163	1	0
ZNF526	116115	broad.mit.edu	37	19	42729117	42729117	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:42729117C>T	uc002osz.1	+	3	718	c.562C>T	c.(562-564)CCC>TCC	p.P188S		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				TCCACCTTCTCCCCCATCCGA	0.597			NA											63	96					0	0	0.00361	0	0
CLPTM1	1209	broad.mit.edu	37	19	45495879	45495879	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:45495879C>T	uc002pai.2	+	14	1749	c.1734C>T	c.(1732-1734)TTC>TTT	p.F578F	CLPTM1_uc010xxf.1_Silent_p.F476F|CLPTM1_uc010xxg.1_Silent_p.F564F	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	578	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		ATGTGGTTTTCTTCATCTACC	0.647			NA											11	36					0	0	0.00245	0	0
EML2	24139	broad.mit.edu	37	19	46116800	46116800	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:46116800C>A	uc002pcn.2	-	18	1858	c.1823G>T	c.(1822-1824)CGA>CTA	p.R608L	EML2_uc002pco.2_RNA|EML2_uc002pcp.2_Missense_Mutation_p.R492L|EML2_uc010xxl.1_Missense_Mutation_p.R755L|EML2_uc010xxm.1_Missense_Mutation_p.R809L	NM_012155	NP_036287	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like	608	WD 10.				sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		GGGACTCACTCGAGGCTGACA	0.473			NA											46	68					5.86059e-21	7.94868e-21	0.00361	1	0
TRPM4	54795	broad.mit.edu	37	19	49691969	49691969	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:49691969C>T	uc002pmw.2	+	13	1887	c.1815C>T	c.(1813-1815)GAC>GAT	p.D605D	TRPM4_uc010emu.2_Silent_p.D605D|TRPM4_uc010yak.1_Silent_p.D69D|TRPM4_uc002pmx.2_Silent_p.D431D|TRPM4_uc010emv.2_Silent_p.D490D|TRPM4_uc010yal.1_Silent_p.D251D|TRPM4_uc002pmy.2_Translation_Start_Site	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	605	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		TGGAGCCTGACGCTGAGGAGG	0.642			NA											14	38					0	0	0.001882	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50462124	50462124	+	Missense_Mutation	SNP	G	G	C	rs149136670	byFrequency	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:50462124G>C	uc010ybh.1	-	7	1230	c.1139C>G	c.(1138-1140)CCG>CGG	p.P380R	SIGLEC11_uc010ybi.1_Missense_Mutation_p.P380R	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	380	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		CTCCAGGACCGGGAGGGATGT	0.672			NA											11	21					0	0	0.00499	0	0
NR1H2	7376	broad.mit.edu	37	19	50885781	50885781	+	Silent	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:50885781G>A	uc010enw.2	+	11	1584	c.1308G>A	c.(1306-1308)TCG>TCA	p.S436S	NR1H2_uc002prv.3_RNA|NR1H2_uc002prz.3_Silent_p.S391S|NR1H2_uc002psa.3_Silent_p.S338S|POLD1_uc002psb.3_5'Flank|POLD1_uc002psc.3_5'Flank|POLD1_uc010enx.2_5'Flank	NM_007121	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	435	Ligand-binding (Potential).				negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		CTGTGCACTCGGAGCAGGTCT	0.672			NA											3	5					0	0	0.000602	0	0
MYBPC2	4606	broad.mit.edu	37	19	50957609	50957609	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:50957609G>A	uc002psf.2	+	18	2048	c.1997G>A	c.(1996-1998)GGG>GAG	p.G666E		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	666	Fibronectin type-III 1.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		ATGTACGATGGGGGGAAGCCA	0.507			NA											40	58					0	0	0.00361	0	0
C19orf75	284369	broad.mit.edu	37	19	51770634	51770634	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:51770634C>A	uc002pwb.1	+	5	799	c.418C>A	c.(418-420)CAT>AAT	p.H140N	C19orf75_uc010eov.1_RNA|C19orf75_uc010ycw.1_Missense_Mutation_p.H46N	NM_173635	NP_775906	Q8N7X8	CS075_HUMAN	hypothetical protein LOC284369	140						integral to membrane				ovary(1)|pancreas(1)	2						TAGAGTGAAACATATCAGAAA	0.453			NA											81	244					1.36798e-35	2.12259e-35	0.00361	1	0
ZNF610	162963	broad.mit.edu	37	19	52869019	52869019	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:52869019G>T	uc002pyx.3	+	6	794	c.388G>T	c.(388-390)GAG>TAG	p.E130*	ZNF610_uc002pyy.3_Nonsense_Mutation_p.E130*|ZNF610_uc002pyz.3_Nonsense_Mutation_p.E87*|ZNF610_uc002pza.2_Nonsense_Mutation_p.E130*	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	130					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		ATTAACCCTTGAGGCACATCT	0.398			NA											77	134					3.11363e-52	5.16826e-52	0.00361	1	0
NLRP12	91662	broad.mit.edu	37	19	54314478	54314478	+	Silent	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:54314478C>A	uc002qch.3	-	3	655	c.435G>T	c.(433-435)GCG>GCT	p.A145A	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Silent_p.A145A|NLRP12_uc002qcj.3_Silent_p.A145A|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Silent_p.A145A	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	145					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CCCCTAGGCGCGCATTGCGGT	0.567			NA											30	67					2.6416e-12	3.22298e-12	0.00623	1	0
KIR3DL1	3811	broad.mit.edu	37	19	55378056	55378056	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:55378056G>T	uc002qhl.3	+	9	1301	c.1238G>T	c.(1237-1239)CGC>CTC	p.R413L	KIR3DL2_uc010esh.2_Missense_Mutation_p.R396L|KIR3DL2_uc002qho.3_Missense_Mutation_p.R413L			P43629	KI3L1_HUMAN	SubName: Full=KIR3DS1;	413	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		AAAATCAGTCGCCCTTCTCAG	0.517			NA											312	499					7.70712e-192	1.4242e-191	0.00361	1	0
NLRP4	147945	broad.mit.edu	37	19	56392837	56392837	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:56392837C>A	uc002qmd.3	+	10	3291	c.2869C>A	c.(2869-2871)CTG>ATG	p.L957M	NLRP4_uc002qmf.2_Missense_Mutation_p.L882M|NLRP4_uc010etf.2_Missense_Mutation_p.L732M	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	957	LRR 8.			L -> P (in Ref. 4; AAL88672).			ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TTTTACCAGGCTGAGAAAAAC	0.418			NA											13	18					1.67942e-08	1.91789e-08	0.006122	1	0
SNTG2	54221	broad.mit.edu	37	2	1168851	1168851	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:1168851C>A	uc002qwq.2	+	8	701	c.573C>A	c.(571-573)AAC>AAA	p.N191K	SNTG2_uc010ewi.2_Intron	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	191					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding	p.N191K(1)		ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		TGCATCTGAACGGAAACTCCA	0.448			NA											161	338					4.95515e-46	8.01526e-46	0.00361	1	0
PXDN	7837	broad.mit.edu	37	2	1652268	1652268	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:1652268T>A	uc002qxa.2	-	17	3348	c.3284A>T	c.(3283-3285)CAC>CTC	p.H1095L		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1095					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		AAGGGGGAGGTGATCTTGTGC	0.582			NA											6	10					0	0	0.00308	0	0
TTC15	51112	broad.mit.edu	37	2	3405596	3405596	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:3405596G>T	uc002qxm.1	+	3	1302	c.1096G>T	c.(1096-1098)GCA>TCA	p.A366S	TTC15_uc002qxn.1_Missense_Mutation_p.A366S|TTC15_uc010ewm.1_Missense_Mutation_p.A366S	NM_016030	NP_057114	Q8WVT3	TTC15_HUMAN	tetratricopeptide repeat domain 15	366							binding			ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.214)		OV - Ovarian serous cystadenocarcinoma(76;0.0402)|Epithelial(75;0.0986)|all cancers(51;0.149)		TGAAAAAGCTGCAGCAAAGAG	0.378			NA											67	125					3.20846e-33	4.78338e-33	0.00361	1	0
ASAP2	8853	broad.mit.edu	37	2	9525405	9525405	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:9525405C>T	uc002qzh.2	+	21	2388	c.2048C>T	c.(2047-2049)TCT>TTT	p.S683F	ASAP2_uc002qzi.2_Missense_Mutation_p.S683F	NM_003887	NP_003878	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	683					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0						AGATTTAATTCTCACGTTCAC	0.483			NA											8	174					0	0	0.008291	0	0
APOB	338	broad.mit.edu	37	2	21224784	21224784	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:21224784C>T	uc002red.2	-	29	13638	c.13510G>A	c.(13510-13512)GAC>AAC	p.D4504N		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4504					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GAGAGTTGGTCTGAAAAATCT	0.358			NA											18	49					0	0	0.007413	0	0
TMEM214	54867	broad.mit.edu	37	2	27262916	27262916	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:27262916G>T	uc002ria.3	+	15	1751	c.1641G>T	c.(1639-1641)CTG>CTT	p.L547L	TMEM214_uc010yle.1_RNA|TMEM214_uc002rib.3_Silent_p.L502L	NM_017727	NP_060197	Q6NUQ4	TM214_HUMAN	transmembrane protein 214 isoform 1	547						integral to membrane	protein binding				0						GGGAGACACTGCCGCTCTGGG	0.627			NA											6	13					5.50884e-06	6.00295e-06	0.001368	1	0
XDH	7498	broad.mit.edu	37	2	31570447	31570447	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:31570447G>C	uc002rnv.1	-	29	3296	c.3217C>G	c.(3217-3219)CCC>GCC	p.P1073A		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	1073					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GAGGTGTTGGGCACAGTGTTA	0.562	Colon(66;682 1445 30109 40147)		NA											34	58					0	0	0.00361	0	0
THUMPD2	80745	broad.mit.edu	37	2	39997215	39997215	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:39997215C>A	uc002rru.2	-	3	344	c.307G>T	c.(307-309)GGA>TGA	p.G103*	THUMPD2_uc002rrv.2_RNA|THUMPD2_uc010ynt.1_Nonsense_Mutation_p.G10*|THUMPD2_uc010ynu.1_Nonsense_Mutation_p.G103*	NM_025264	NP_079540	Q9BTF0	THUM2_HUMAN	THUMP domain containing 2	103							methyltransferase activity			skin(1)	1		all_hematologic(82;0.248)				AACCAACTTCCTGGATCTTCA	0.289			NA											6	18					0.00448238	0.00463667	0.004482	1	0
SLC8A1	6546	broad.mit.edu	37	2	40656621	40656621	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:40656621C>A	uc002rrx.2	-	1	824	c.800G>T	c.(799-801)CGA>CTA	p.R267L	SLC8A1_uc002rry.2_Missense_Mutation_p.R267L|SLC8A1_uc002rrz.2_Missense_Mutation_p.R267L|SLC8A1_uc002rsa.2_Missense_Mutation_p.R267L|SLC8A1_uc002rsd.3_Missense_Mutation_p.R267L|SLC8A1_uc002rsb.1_Missense_Mutation_p.R267L|SLC8A1_uc010fan.1_Missense_Mutation_p.R267L|SLC8A1_uc002rsc.1_Missense_Mutation_p.R267L	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	267	Calmodulin-binding (Potential).|Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding	p.R267L(1)		ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CTTGCCAGCTCGATACCTCTT	0.433			NA											76	181					8.92586e-32	1.31357e-31	0.00361	1	0
FSHR	2492	broad.mit.edu	37	2	49190064	49190064	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:49190064G>T	uc002rww.2	-	10	1970	c.1896C>A	c.(1894-1896)AAC>AAA	p.N632K	FSHR_uc002rwx.2_Missense_Mutation_p.N570K|FSHR_uc010fbn.2_Missense_Mutation_p.N606K	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	632	Cytoplasmic (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding	p.N632K(1)		ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	CTCTGCGAAAGTTTTTGGTAA	0.463			NA							Gonadal_Dysgenesis_46_XX				34	76					2.32173e-10	2.7278e-10	0.004878	1	0
VRK2	7444	broad.mit.edu	37	2	58350345	58350345	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:58350345G>T	uc002rzo.2	+	11	1398	c.653G>T	c.(652-654)AGC>ATC	p.S218I	VRK2_uc010fcb.2_Missense_Mutation_p.S218I|VRK2_uc002rzs.2_Missense_Mutation_p.S218I|VRK2_uc002rzr.2_Missense_Mutation_p.S218I|VRK2_uc010fcc.2_Missense_Mutation_p.S100I|VRK2_uc002rzv.2_Missense_Mutation_p.S218I|VRK2_uc010fcd.2_Missense_Mutation_p.S195I|VRK2_uc002rzp.2_Missense_Mutation_p.S218I|VRK2_uc010ypg.1_Missense_Mutation_p.S218I|VRK2_uc002rzq.2_Missense_Mutation_p.S218I|VRK2_uc002rzu.2_Missense_Mutation_p.S218I|VRK2_uc002rzt.2_Missense_Mutation_p.S100I|VRK2_uc010yph.1_Missense_Mutation_p.S100I	NM_001130482	NP_001123954	Q86Y07	VRK2_HUMAN	vaccinia related kinase 2 isoform 2	218	Protein kinase.					integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1						GAGTTTACCAGCTTGGATGCC	0.388			NA											66	124					3.83446e-41	6.13298e-41	0.00361	1	0
ETAA1	54465	broad.mit.edu	37	2	67630052	67630052	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:67630052C>T	uc002sdz.1	+	4	627	c.488C>T	c.(487-489)CCT>CTT	p.P163L		NM_019002	NP_061875	Q9NY74	ETAA1_HUMAN	ETAA16 protein	163						cytoplasm|nucleus				ovary(3)|large_intestine(1)	4						ACTGCTATTCCTTGTACTCCC	0.368			NA											40	69					0	0	0.00361	0	0
HTRA2	27429	broad.mit.edu	37	2	74759976	74759976	+	Nonsense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:74759976T>A	uc002smi.1	+	8	1843	c.1241T>A	c.(1240-1242)TTG>TAG	p.L414*	HTRA2_uc002smj.1_Nonsense_Mutation_p.L317*|HTRA2_uc002smk.1_Nonsense_Mutation_p.L392*|HTRA2_uc002sml.1_Nonsense_Mutation_p.L382*|HTRA2_uc002smm.1_Nonsense_Mutation_p.L155*|HTRA2_uc002smn.1_Nonsense_Mutation_p.L155*|LOXL3_uc002smo.1_3'UTR|LOXL3_uc010ffm.1_3'UTR|LOXL3_uc002smp.1_3'UTR|LOXL3_uc002smq.1_3'UTR	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	414	PDZ.				apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1						GATGTGATTTTGGCCATTGGG	0.498			NA											101	156					0	0	0.00361	0	0
CREG2	200407	broad.mit.edu	37	2	101967438	101967438	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:101967438C>A	uc002tba.2	-	4	866	c.820G>T	c.(820-822)GCA>TCA	p.A274S		NM_153836	NP_722578	Q8IUH2	CREG2_HUMAN	cellular repressor of E1A-stimulated genes 2	274						extracellular region	FMN binding			ovary(1)	1						ATACTGGATGCGCCTCCATAC	0.443			NA											41	83					1.06522e-23	1.47631e-23	0.003214	1	0
PROC	5624	broad.mit.edu	37	2	128186390	128186390	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:128186390C>T	uc002tok.2	+	9	1327	c.1254C>T	c.(1252-1254)GGC>GGT	p.G418G	PROC_uc002tol.2_Silent_p.G439G|PROC_uc010yzi.1_Silent_p.G474G|PROC_uc010yzj.1_Silent_p.G313G|PROC_uc010yzk.1_Silent_p.G473G|PROC_uc002tom.2_Silent_p.G452G	NM_000312	NP_000303	P04070	PROC_HUMAN	protein C	418	Peptidase S1.		G -> D (in ARPROCD; Hong Kong-2).		blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	TCCTGGTGGGCCTGGTGAGCT	0.647			NA											13	18					0	0	0.004007	0	0
POTEF	728378	broad.mit.edu	37	2	130832708	130832708	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:130832708C>A	uc010fmh.2	-	17	2737	c.2337G>T	c.(2335-2337)TGG>TGT	p.W779C		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	779	Actin-like.					cell cortex	ATP binding			skin(3)|ovary(2)	5						CCATGTCATCCCAGTTGGTGA	0.577			NA											42	77					1.22102e-19	1.6214e-19	0.00361	1	0
NCKAP5	344148	broad.mit.edu	37	2	133541594	133541594	+	Silent	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:133541594C>A	uc002ttp.2	-	14	3164	c.2790G>T	c.(2788-2790)CCG>CCT	p.P930P	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	930	Poly-Pro.						protein binding				0						CTGGAGGGGGCGGAGGGGAAG	0.622			NA											6	9					3.09899e-07	3.46965e-07	0.004482	1	0
LRP1B	53353	broad.mit.edu	37	2	141116451	141116451	+	Silent	SNP	C	C	T	rs138052993	byFrequency	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:141116451C>T	uc002tvj.1	-	73	12168	c.11196G>A	c.(11194-11196)TCG>TCA	p.S3732S		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3732	Extracellular (Potential).|LDL-receptor class A 31.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACATTTGCTCCGACTGTAGGC	0.383	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			13	406					0	0	0.003163	0	0
PLA2R1	22925	broad.mit.edu	37	2	160901382	160901382	+	Silent	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:160901382C>A	uc002ube.1	-	2	603	c.396G>T	c.(394-396)GTG>GTT	p.V132V	PLA2R1_uc010zcp.1_Silent_p.V132V|PLA2R1_uc002ubf.2_Silent_p.V132V	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	132	Extracellular (Potential).|Ricin B-type lectin.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						TGTCATGCGCCACCTGGACAG	0.478			NA											108	153					2.93447e-47	4.78738e-47	0.00361	1	0
FAP	2191	broad.mit.edu	37	2	163082062	163082062	+	Silent	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:163082062T>A	uc002ucd.2	-	4	424	c.216A>T	c.(214-216)GCA>GCT	p.A72A	FAP_uc010zct.1_Silent_p.A72A|FAP_uc010fpd.2_Intron|FAP_uc010fpe.1_Silent_p.A39A	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	72	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						TATTGTTATCTGCAGATTGAT	0.303			NA											29	49					0	0	0.003755	0	0
FIGN	55137	broad.mit.edu	37	2	164468190	164468190	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:164468190T>A	uc002uck.1	-	3	463	c.152A>T	c.(151-153)CAG>CTG	p.Q51L		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	51						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						CCAGGCGTACTGATAGGTGCG	0.502			NA											181	342					0	0	0.00361	0	0
XIRP2	129446	broad.mit.edu	37	2	168101224	168101224	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:168101224G>T	uc002udx.2	+	8	3340	c.3322G>T	c.(3322-3324)GAA>TAA	p.E1108*	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Nonsense_Mutation_p.E933*|XIRP2_uc010fpq.2_Nonsense_Mutation_p.E886*|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	933					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GTCTCTTTATGAAAAAGTTTC	0.363			NA											16	39					4.63292e-17	5.97156e-17	0.008871	1	0
C2orf77	129881	broad.mit.edu	37	2	170518803	170518803	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:170518803C>A	uc002ufe.2	-	5	900	c.806G>T	c.(805-807)AGG>ATG	p.R269M		NM_001085447	NP_001078916	Q0VFZ6	CB077_HUMAN	hypothetical protein LOC129881	269	Potential.										0						AAACCGTCTCCTGCTTTCATG	0.289			NA											251	372					1.68934e-126	3.05257e-126	0.00361	1	0
HOXD11	3237	broad.mit.edu	37	2	176973838	176973838	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:176973838C>A	uc002uki.2	+	2	985	c.985C>A	c.(985-987)CTG>ATG	p.L329M	HOXD11_uc010fqx.2_RNA	NM_021192	NP_067015	P31277	HXD11_HUMAN	homeobox D11	329						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0521)|READ - Rectum adenocarcinoma(9;0.0678)		CAGAGACCGTCTGCAGTATTT	0.532			NA	T	NUP98	AML								54	71					1.55088e-19	2.0499e-19	0.00361	1	0
PTH2R	5746	broad.mit.edu	37	2	209302298	209302298	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:209302298G>T	uc002vdb.2	+	3	428	c.215G>T	c.(214-216)TGT>TTT	p.C72F	PTH2R_uc010zjb.1_Missense_Mutation_p.C83F	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	72	Extracellular (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		GGACTCATTTGTTGGCCCAGA	0.333			NA											24	42					3.90053e-15	4.90573e-15	0.002445	1	0
SPHKAP	80309	broad.mit.edu	37	2	228884540	228884540	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:228884540C>G	uc002vpq.2	-	7	1077	c.1030G>C	c.(1030-1032)GCT>CCT	p.A344P	SPHKAP_uc002vpp.2_Missense_Mutation_p.A344P|SPHKAP_uc010zlx.1_Missense_Mutation_p.A344P	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	344						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GAGAAATAAGCATCTTTTGGA	0.423			NA											30	105					0	0	0.002096	0	0
PER2	8864	broad.mit.edu	37	2	239157728	239157729	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:239157728_239157729CC>AA	uc002vyc.2	-	22	3829_3830	c.3592_3593GG>TT	c.(3592-3594)GGC>TTC	p.G1198F	PER2_uc010znv.1_Missense_Mutation_p.G1198F	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	1198	CRY binding domain (By similarity).				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		TGCGGGCAGGCCGCCCGTCTGC	0.515			NA											18	57					0	0	0.004672	0	0
CPXM1	56265	broad.mit.edu	37	20	2775235	2775235	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr20:2775235C>T	uc002wgu.2	-	13	1975	c.1911G>A	c.(1909-1911)GGG>GGA	p.G637G	CPXM1_uc010gas.2_Silent_p.G563G	NM_019609	NP_062555	Q96SM3	CPXM1_HUMAN	carboxypeptidase X, member 1 precursor	637					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding	p.G637E(1)		ovary(2)|skin(2)	4						CGTCAGCAATCCCAAGCTCCG	0.468			NA											9	104					0	0	0.000978	0	0
PAX1	5075	broad.mit.edu	37	20	21695388	21695388	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr20:21695388C>T	uc002wsj.2	+	5	1606	c.1552C>T	c.(1552-1554)CCA>TCA	p.P518S	PAX1_uc010zsl.1_3'UTR|PAX1_uc010zsm.1_3'UTR	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	518					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						GCCGGACCCACCACACTTCCT	0.637			NA											7	14					0	0	0.001984	0	0
GZF1	64412	broad.mit.edu	37	20	23345114	23345114	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr20:23345114G>A	uc010gdb.2	+	3	268	c.94G>A	c.(94-96)GAC>AAC	p.D32N	GZF1_uc002wsy.2_Missense_Mutation_p.D32N|GZF1_uc010zsq.1_Intron|GZF1_uc010zsr.1_Intron|GZF1_uc002wsz.2_Missense_Mutation_p.D32N	NM_022482	NP_071927	Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	32	BTB.			D->N: Decreased repression activity.	transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			kidney(1)	1	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					TCACCTGTGTGACGTGACAGT	0.517			NA											4	39					0	0	0.001168	0	0
C20orf191	149934	broad.mit.edu	37	20	26084304	26084304	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr20:26084304G>T	uc002wvj.3	-	2	167	c.112C>A	c.(112-114)CCA>ACA	p.P38T		NR_003678				SubName: Full=Putative uncharacterized protein ENSP00000323172;												0						CCAAATGCTGGATCCTTTAGA	0.393			NA											15	100					2.48551e-13	3.07858e-13	0.00499	1	0
CASS4	57091	broad.mit.edu	37	20	55012236	55012236	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr20:55012236C>A	uc002xxp.2	+	3	278	c.53C>A	c.(52-54)GCA>GAA	p.A18E	CASS4_uc002xxq.3_Missense_Mutation_p.A18E|CASS4_uc002xxr.2_Missense_Mutation_p.A18E|CASS4_uc010zze.1_Missense_Mutation_p.A18E|CASS4_uc010gio.2_Missense_Mutation_p.A18E	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	18	SH3.				cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						CTGGCCAGGGCACTTTATGAC	0.557			NA											83	130					7.4264e-54	1.23629e-53	0.00361	1	0
Unknown	0	broad.mit.edu	37	20	56063476	56063476	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr20:56063476T>A	uc010zzl.1	-	1	608	c.608A>T	c.(607-609)GAA>GTA	p.E203V		NM_001008735	NP_001008735			high-mobility group box 1-like 1												NA						ttcttcatcttcttcatcttc	0.219			NA											20	33					0	0	0.001882	0	0
TPTE	7179	broad.mit.edu	37	21	10920156	10920156	+	Silent	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr21:10920156C>A	uc002yip.1	-	19	1466	c.1098G>T	c.(1096-1098)CTG>CTT	p.L366L	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Silent_p.L348L|TPTE_uc002yir.1_Silent_p.L328L|TPTE_uc010gkv.1_Silent_p.L228L	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	366	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAAAATAATACAGGCTTTCCT	0.383			NA											12	259					2.23348e-06	2.46201e-06	0.004007	1	0
TMPRSS15	5651	broad.mit.edu	37	21	19687505	19687505	+	Missense_Mutation	SNP	C	C	A	rs139992374		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr21:19687505C>A	uc002ykw.2	-	17	2021	c.1990G>T	c.(1990-1992)GGT>TGT	p.G664C		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	664	Extracellular (Potential).|LDL-receptor class A 2.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						TGCAGATGACCGTCACAGAGA	0.398			NA											128	232					6.32167e-57	1.07751e-56	0.00361	1	0
ADAMTS1	9510	broad.mit.edu	37	21	28212677	28212677	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr21:28212677C>T	uc002ymf.2	-	5	2038	c.1583G>A	c.(1582-1584)TGG>TAG	p.W528*		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1	528	Disintegrin.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)		GCCATCCGCCCACGGGAAGTG	0.522			NA											58	53					0	0	0.00361	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28302275	28302275	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr21:28302275C>A	uc002ymg.2	-	7	2884	c.2155G>T	c.(2155-2157)GAC>TAC	p.D719Y		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	719	Cys-rich.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						CCGCACTTGTCATACTGCAGC	0.458	Esophageal Squamous(53;683 1080 10100 14424 45938)		NA											78	443					2.70612e-23	3.73235e-23	0.00361	1	0
ADAMTS5	11096	broad.mit.edu	37	21	28304454	28304454	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr21:28304454G>T	uc002ymg.2	-	6	2647	c.1918C>A	c.(1918-1920)CAG>AAG	p.Q640K		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	640	Cys-rich.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						GCATCAGACTGATAGCCATTT	0.418	Esophageal Squamous(53;683 1080 10100 14424 45938)		NA											20	189					6.21321e-17	7.97246e-17	0.00278	1	0
N6AMT1	29104	broad.mit.edu	37	21	30252218	30252218	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr21:30252218G>T	uc002ymo.1	-	4	396	c.370C>A	c.(370-372)CCC>ACC	p.P124T	N6AMT1_uc002ymp.1_Intron|N6AMT1_uc002ymq.1_RNA	NM_013240	NP_037372	Q9Y5N5	HEMK2_HUMAN	N-6 adenine-specific DNA methyltransferase 1	124	Substrate binding (By similarity).				positive regulation of cell growth	protein complex	nucleic acid binding|protein binding|protein methyltransferase activity				0						ACTACATAGGGGGGATTAAAC	0.303			NA											37	202					6.08268e-21	8.23036e-21	0.00361	1	0
CLDN8	9073	broad.mit.edu	37	21	31588059	31588059	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr21:31588059A>T	uc002ynu.1	-	1	260	c.185T>A	c.(184-186)ATG>AAG	p.M62K		NM_199328	NP_955360	P56748	CLD8_HUMAN	claudin 8	62	Extracellular (Potential).				calcium-independent cell-cell adhesion	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity				0						TTTGCACTGCATCCTGATGTT	0.498			NA											33	186					0	0	0.00361	0	0
ITSN1	6453	broad.mit.edu	37	21	35124178	35124178	+	Missense_Mutation	SNP	A	A	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr21:35124178A>C	uc002yta.1	+	7	858	c.590A>C	c.(589-591)AAA>ACA	p.K197T	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.K197T|ITSN1_uc010gmg.2_Missense_Mutation_p.K160T|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.K197T|ITSN1_uc010gmi.2_Missense_Mutation_p.K160T|ITSN1_uc010gmj.2_Missense_Mutation_p.K81T|ITSN1_uc002ysy.2_Missense_Mutation_p.K197T|ITSN1_uc002ysx.2_Missense_Mutation_p.K160T|ITSN1_uc002ytb.1_Missense_Mutation_p.K197T|ITSN1_uc002ytc.1_Missense_Mutation_p.K197T|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.K160T|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.K197T|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.K131T	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	197					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						CTAAACACTAAATTACAAAAG	0.338			NA											104	76					0	0	0.00361	0	0
KRTAP10-9	386676	broad.mit.edu	37	21	46047579	46047579	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr21:46047579A>T	uc002zfp.3	+	1	540	c.491A>T	c.(490-492)CAA>CTA	p.Q164L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198690	NP_941963	P60411	KR109_HUMAN	keratin associated protein 10-9	164	15.|25 X 5 AA repeats of C-C-X(3).					keratin filament					0						TCATGCTGCCAACAGTCTAGC	0.448			NA											57	245					0	0	0.00361	0	0
DIP2A	23181	broad.mit.edu	37	21	47978160	47978160	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr21:47978160G>T	uc002zjo.2	+	32	4006	c.3823G>T	c.(3823-3825)GTG>TTG	p.V1275L	DIP2A_uc011afz.1_Missense_Mutation_p.V1271L|DIP2A_uc002zjr.2_Missense_Mutation_p.V242L	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	1275					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CCTGTCATGTGTGCGCACGTG	0.657			NA											6	12					8.12818e-05	8.67513e-05	0.001984	1	0
RTDR1	27156	broad.mit.edu	37	22	23401723	23401723	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr22:23401723C>A	uc002zwt.2	-	7	1122	c.964G>T	c.(964-966)GAG>TAG	p.E322*		NM_014433	NP_055248	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region protein 1	322							binding			ovary(1)	1	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		TCGTAAGTCTCCACCTCCATG	0.617			NA											30	38					1.36161e-19	1.8039e-19	0.004289	1	0
CRYBA4	1413	broad.mit.edu	37	22	27019232	27019232	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr22:27019232G>T	uc003acz.3	+	3	109	c.74G>T	c.(73-75)CGG>CTG	p.R25L		NM_001886	NP_001877	P53673	CRBA4_HUMAN	crystallin, beta A4	25	Beta/gamma crystallin 'Greek key' 1.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens				0						TTCCAGGGCCGGCGGCACGAG	0.602			NA											14	69					2.21704e-12	2.71076e-12	0.00278	1	0
SLC5A4	6527	broad.mit.edu	37	22	32620393	32620393	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr22:32620393C>A	uc003ami.2	-	13	1528	c.1526G>T	c.(1525-1527)GGG>GTG	p.G509V		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	509	Extracellular (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						CAAGCAACTCCCTGTTCCATA	0.458			NA											9	88					3.45872e-05	3.72628e-05	0.004007	1	0
CSF2RB	1439	broad.mit.edu	37	22	37329915	37329915	+	Silent	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr22:37329915C>A	uc003aqa.3	+	10	1411	c.1194C>A	c.(1192-1194)GCC>GCA	p.A398A	CSF2RB_uc003aqc.3_Silent_p.A404A	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	398	Extracellular (Potential).|Fibronectin type-III 2.				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	ACAGCATGGCCCTGCCAGCCC	0.677			NA											13	2					1.10513e-12	1.35706e-12	0.002299	1	0
IL2RB	3560	broad.mit.edu	37	22	37532295	37532295	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr22:37532295G>T	uc003aqv.1	-	7	807	c.676C>A	c.(676-678)CCC>ACC	p.P226T		NM_000878	NP_000869	P14784	IL2RB_HUMAN	interleukin 2 receptor beta precursor	226	Extracellular (Potential).|Fibronectin type-III.				interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity				0					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	AAGGCCAGGGGCTGGCTCCAG	0.647			NA											19	34					4.54149e-19	5.98889e-19	0.002299	1	0
IL17REL	400935	broad.mit.edu	37	22	50438923	50438923	+	Missense_Mutation	SNP	C	C	A	rs137904241		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr22:50438923C>A	uc003bje.1	-	6	550	c.318G>T	c.(316-318)CAG>CAT	p.Q106H		NM_001001694	NP_001001694	Q6ZVW7	I17EL_HUMAN	interleukin 17 receptor E-like	106										pancreas(1)	1		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		CGAGGTGCCTCTGGTCCAGCT	0.652			NA											4	5					0.00909568	0.00927435	0.009096	1	0
KLHDC7B	113730	broad.mit.edu	37	22	50987690	50987690	+	Silent	SNP	C	C	T	rs147168342	byFrequency	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr22:50987690C>T	uc003bmi.2	+	1	1229	c.1095C>T	c.(1093-1095)TCC>TCT	p.S365S		NM_138433	NP_612442	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	365	Kelch 2.									central_nervous_system(1)	1		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TCCGTGGCTCCGGTGCCAAGG	0.672			NA											2	1					0	0	0.004672	0	0
CHL1	10752	broad.mit.edu	37	3	433422	433422	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr3:433422G>T	uc003bou.2	+	22	3079	c.2808G>T	c.(2806-2808)TGG>TGT	p.W936C	CHL1_uc003bot.2_Missense_Mutation_p.W952C|CHL1_uc003bow.1_Missense_Mutation_p.W936C|CHL1_uc011asi.1_Missense_Mutation_p.W952C	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	936	Fibronectin type-III 4.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CTTTATCTTGGGGACTACCTA	0.323			NA											40	21					6.07928e-31	8.87792e-31	0.009718	1	0
DLEC1	9940	broad.mit.edu	37	3	38104226	38104226	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr3:38104226C>T	uc003cho.1	+	5	1049	c.1028C>T	c.(1027-1029)TCT>TTT	p.S343F	DLEC1_uc003chp.1_Missense_Mutation_p.S343F|DLEC1_uc010hgv.1_Missense_Mutation_p.S343F|DLEC1_uc010hgw.1_Missense_Mutation_p.S42F|DLEC1_uc003chq.1_RNA	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	343					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		GGAGGCAAGTCTCTTGTTTTT	0.458			NA											18	12					0	0	0.002299	0	0
XIRP1	165904	broad.mit.edu	37	3	39229235	39229235	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr3:39229235G>T	uc003cjk.1	-	2	1923	c.1702C>A	c.(1702-1704)CAG>AAG	p.Q568K	XIRP1_uc003cji.2_Missense_Mutation_p.Q568K|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	568	Interaction with CTNNB1 (By similarity).						actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TGTCGTTCCTGCTGCTCCCGT	0.617			NA											17	4					2.41591e-17	3.12101e-17	0.004656	1	0
ZNF35	7584	broad.mit.edu	37	3	44700712	44700713	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr3:44700712_44700713CC>AA	uc003cnq.2	+	4	1078_1079	c.857_858CC>AA	c.(856-858)GCC>GAA	p.A286E	ZNF35_uc003cnr.2_Missense_Mutation_p.A126E	NM_003420	NP_003411	P13682	ZNF35_HUMAN	zinc finger protein 35	286	C2H2-type 3.				cellular response to retinoic acid|spermatogenesis	nucleus|perinuclear region of cytoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(412;0.0228)		OV - Ovarian serous cystadenocarcinoma(275;2.49e-27)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)		TGTGGGAAAGCCTTCACTCAGA	0.411			NA											43	26					0	0	0.004672	0	0
PRSS42	339906	broad.mit.edu	37	3	46873408	46873408	+	Silent	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr3:46873408C>A	uc011bap.1	-	4	750	c.750G>T	c.(748-750)GGG>GGT	p.G250G	PRSS42_uc003cqj.2_Intron	NM_182702	NP_874361	Q7Z5A4	PRS42_HUMAN	testis serine protease 2 precursor	250	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			pancreas(1)	1						CACAGACCATCCCTTTTATTA	0.383			NA											43	26					1.47857e-17	1.91879e-17	0.00361	1	0
KIF9	64147	broad.mit.edu	37	3	47286357	47286357	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr3:47286357C>T	uc010hjp.2	-	16	2042	c.1438G>A	c.(1438-1440)GGA>AGA	p.G480R	KIF9_uc003cqx.2_Missense_Mutation_p.G480R|KIF9_uc003cqy.2_Missense_Mutation_p.G480R|KIF9_uc011bat.1_RNA	NM_001134878	NP_001128350	Q9HAQ2	KIF9_HUMAN	kinesin family member 9 isoform 2	480					blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		ACTCCGAGTCCAAAGTTTTGT	0.527	Colon(44;962 1147 15977 24541)		NA											3	39					0	0	0.009096	0	0
EPHA3	2042	broad.mit.edu	37	3	89456501	89456501	+	Silent	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr3:89456501C>A	uc003dqy.2	+	8	1902	c.1677C>A	c.(1675-1677)GTC>GTA	p.V559V	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	559	Helical; (Potential).					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TCACTGTTGTCATCTATGTTT	0.423			NA								TSP Lung(6;0.00050)			65	68					1.15062e-32	1.7065e-32	0.00361	1	0
PLCXD2	257068	broad.mit.edu	37	3	111427042	111427042	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr3:111427042G>T	uc003dya.2	+	2	1019	c.433G>T	c.(433-435)GAA>TAA	p.E145*	PLCXD2_uc003dyb.2_Nonsense_Mutation_p.E145*|PLCXD2_uc003dxz.2_Nonsense_Mutation_p.E145*	NM_001134478	NP_001127950	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X	145	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(1)	1						TGGGCTGATGGAAATTGACTC	0.493			NA											39	100					4.64027e-19	6.10505e-19	0.00361	1	0
ATP1B3	483	broad.mit.edu	37	3	141632604	141632604	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr3:141632604G>T	uc003eug.1	+	4	631	c.457G>T	c.(457-459)GCA>TCA	p.A153S	ATP1B3_uc011bne.1_RNA|ATP1B3_uc003euh.1_Missense_Mutation_p.A139S	NM_001679	NP_001670	P54709	AT1B3_HUMAN	Na+/K+ -ATPase beta 3 subunit	153	Extracellular (Potential).				ATP biosynthetic process|blood coagulation|leukocyte migration	melanosome|sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity				0						ATTACTTCAAGCATGCAGTGG	0.398			NA											134	69					1.47408e-88	2.60589e-88	0.00361	1	0
B3GNT5	84002	broad.mit.edu	37	3	182988136	182988136	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr3:182988136C>T	uc003flk.2	+	2	1080	c.550C>T	c.(550-552)CCA>TCA	p.P184S	MCF2L2_uc003fli.1_Intron|MCF2L2_uc003flj.1_Intron|MCF2L2_uc011bqr.1_Intron|B3GNT5_uc003fll.2_Missense_Mutation_p.P184S|B3GNT5_uc003flm.2_Missense_Mutation_p.P184S	NM_032047	NP_114436	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal	184	Lumenal (Potential).				central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			ovary(1)	1	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TACCTATTGTCCACATGCCAA	0.333			NA											7	151					0	0	0.004482	0	0
MUC4	4585	broad.mit.edu	37	3	195516223	195516223	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr3:195516223G>C	uc011bto.1	-	2	2688	c.2228C>G	c.(2227-2229)TCT>TGT	p.S743C	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.S625C	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	748					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGACACTACAGAGTTGGCCAG	0.602			NA											13	8					0	0	0.00245	0	0
NOP14	8602	broad.mit.edu	37	4	2954074	2954074	+	Silent	SNP	C	C	T	rs149472162	byFrequency	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:2954074C>T	uc003ggj.1	-	6	870	c.798G>A	c.(796-798)GCG>GCA	p.A266A	C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Silent_p.A12A|NOP14_uc003ggk.3_Silent_p.A266A|NOP14_uc003ggl.2_Silent_p.A266A|NOP14_uc010icq.1_RNA	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	266					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						TAGAGGGCTGCGCCTTCATTT	0.463			NA											3	35					0	0	0.000602	0	0
HS3ST1	9957	broad.mit.edu	37	4	11401489	11401489	+	Silent	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:11401489T>A	uc003gmq.2	-	2	464	c.141A>T	c.(139-141)CCA>CCT	p.P47P		NM_005114	NP_005105	O14792	HS3S1_HUMAN	heparan sulfate D-glucosaminyl	47						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			skin(1)	1						CAGAGCCGTTTGGGGCCACGC	0.692			NA											11	16					0	0	0.001368	0	0
GPR125	166647	broad.mit.edu	37	4	22422541	22422541	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:22422541C>A	uc003gqm.1	-	12	2042	c.1777G>T	c.(1777-1779)GTT>TTT	p.V593F	GPR125_uc010ieo.1_Missense_Mutation_p.V467F|GPR125_uc003gqn.1_Missense_Mutation_p.V367F|GPR125_uc003gqo.2_Missense_Mutation_p.V593F	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	593	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)				GTATTTGAAACATTGCACTTA	0.413			NA											93	420					8.58103e-55	1.44536e-54	0.00361	1	0
CCKAR	886	broad.mit.edu	37	4	26487314	26487314	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:26487314G>T	uc003gse.1	-	3	724	c.571C>A	c.(571-573)CAG>AAG	p.Q191K		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	191	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	TTCGCGGTCTGGTTGTTATTT	0.408			NA											42	132					9.22156e-22	1.26271e-21	0.00361	1	0
PGM2	55276	broad.mit.edu	37	4	37841740	37841740	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:37841740C>T	uc011byb.1	+	6	651	c.578C>T	c.(577-579)TCT>TTT	p.S193F	PGM2_uc011bya.1_Missense_Mutation_p.S54F|PGM2_uc011byc.1_Missense_Mutation_p.S33F	NM_018290	NP_060760	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	193					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			ovary(1)	1						AAAGGGATTTCTCAAGCTATT	0.418			NA											7	212					0	0	0.00308	0	0
EPHA5	2044	broad.mit.edu	37	4	66217258	66217258	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:66217258G>T	uc003hcy.2	-	14	2550	c.2357C>A	c.(2356-2358)GCA>GAA	p.A786E	EPHA5_uc003hcx.2_Missense_Mutation_p.A718E|EPHA5_uc003hcz.2_Missense_Mutation_p.A764E|EPHA5_uc011cah.1_Missense_Mutation_p.A787E|EPHA5_uc011cai.1_Missense_Mutation_p.A765E|EPHA5_uc003hda.2_Missense_Mutation_p.A787E	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	786	Cytoplasmic (Potential).|Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CTTCATTCCTGCAGAGATACC	0.413			NA								TSP Lung(17;0.13)			79	77					1.0627e-70	1.85567e-70	0.00361	1	0
UGT2B28	54490	broad.mit.edu	37	4	70152489	70152489	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:70152489A>T	uc003hej.2	+	3	892	c.890A>T	c.(889-891)CAG>CTG	p.Q297L	UGT2B28_uc010ihr.2_Missense_Mutation_p.Q297L	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	297					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	GAATTTGTACAGAGCTCTGGT	0.403			NA											77	224					0	0	0.00361	0	0
UTP3	57050	broad.mit.edu	37	4	71555768	71555768	+	Silent	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:71555768G>A	uc003hfo.2	+	1	1573	c.1374G>A	c.(1372-1374)GAG>GAA	p.E458E		NM_020368	NP_065101	Q9NQZ2	SAS10_HUMAN	UTP3, small subunit processome component	458					brain development|chromatin modification|gene silencing	nucleolus					0			Lung(101;0.235)			GTAAAGAAGAGCAACGTTATA	0.388			NA											71	127					0	0	0.00361	0	0
AFP	174	broad.mit.edu	37	4	74313324	74313324	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:74313324T>A	uc003hgz.1	+	8	1036	c.989T>A	c.(988-990)CTA>CAA	p.L330Q	AFP_uc003hha.1_Missense_Mutation_p.L330Q|AFP_uc011cbg.1_Missense_Mutation_p.L104Q	NM_001134	NP_001125	P02771	FETA_HUMAN	alpha-fetoprotein precursor	330	Albumin 2.				transport		metal ion binding			ovary(1)	1	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TCTCCAAATCTAAACAGGTTT	0.358			NA							Alpha-Fetoprotein_Hereditary_Persistence_of				32	18					0	0	0.002836	0	0
PRKG2	5593	broad.mit.edu	37	4	82126159	82126159	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:82126159C>A	uc003hmh.2	-	1	57	c.43G>T	c.(43-45)GAT>TAT	p.D15Y	PRKG2_uc011cch.1_Missense_Mutation_p.D15Y	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	15					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						GAGTGTCCATCTGGGTGCTTA	0.502			NA											3	38					0.00909568	0.00927435	0.009096	1	0
SLC10A6	345274	broad.mit.edu	37	4	87770264	87770264	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:87770264C>T	uc003hqd.2	-	1	153	c.5G>A	c.(4-6)AGA>AAA	p.R2K		NM_197965	NP_932069	Q3KNW5	SOAT_HUMAN	sodium-dependent organic anion transporter	2	Extracellular (Potential).					integral to membrane|plasma membrane	bile acid:sodium symporter activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.00099)		ACAATTGGCTCTCATCTCCTC	0.512			NA											6	125					0	0	0.001984	0	0
SPARCL1	8404	broad.mit.edu	37	4	88416205	88416205	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:88416205G>T	uc010ikm.2	-	4	701	c.129C>A	c.(127-129)CCC>CCA	p.P43P	SPARCL1_uc011cdc.1_Intron|SPARCL1_uc003hqs.3_Silent_p.P43P|SPARCL1_uc011cdd.1_5'UTR|SPARCL1_uc003hqt.2_Silent_p.P43P	NM_001128310	NP_001121782	Q14515	SPRL1_HUMAN	SPARC-like 1 precursor	43	O-glycosylated at two sites.				signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		CCCTTAAACTGGGGATTGCAG	0.358			NA											57	108					6.83469e-46	1.10243e-45	0.00361	1	0
BANK1	55024	broad.mit.edu	37	4	102751288	102751288	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:102751288C>T	uc003hvy.3	+	2	668	c.394C>T	c.(394-396)CAA>TAA	p.Q132*	BANK1_uc003hvx.3_Nonsense_Mutation_p.Q117*|BANK1_uc010ill.2_Intron|BANK1_uc003hvz.3_Nonsense_Mutation_p.Q102*	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	132	Interaction with ITPR2.				B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		AAATATCTCTCAAAGCAGATG	0.373			NA											44	85					0	0	0.00361	0	0
SEC24B	10427	broad.mit.edu	37	4	110448546	110448546	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:110448546G>T	uc003hzk.2	+	18	3089	c.3034G>T	c.(3034-3036)GGA>TGA	p.G1012*	SEC24B_uc003hzl.2_Nonsense_Mutation_p.G977*|SEC24B_uc011cfp.1_Nonsense_Mutation_p.G1042*|SEC24B_uc011cfq.1_Nonsense_Mutation_p.G1011*|SEC24B_uc011cfr.1_Nonsense_Mutation_p.G976*	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	1012					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		TGTATATGCGGGAGTGGATGT	0.368			NA											55	58					1.38705e-31	2.03601e-31	0.00361	1	0
ANK2	287	broad.mit.edu	37	4	114158753	114158754	+	Splice_Site	DNP	AG	AG	TA			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	AG	AG	-	-	AG	AG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:114158753_114158754AG>TA	uc003ibe.3	+	7	770	c.670_splice	c.e7-1	p.M224_splice	ANK2_uc003ibd.3_Splice_Site_p.M203_splice|ANK2_uc003ibf.3_Splice_Site_p.M224_splice|ANK2_uc003ibc.2_Splice_Site_p.M200_splice|ANK2_uc011cgb.1_Splice_Site_p.M239_splice	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1						axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ACACTGCTTCAGATGATGGTGA	0.361			NA											41	62					0	0	0.004672	0	0
ANK2	287	broad.mit.edu	37	4	114276963	114276963	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:114276963T>C	uc003ibe.3	+	38	7289	c.7189T>C	c.(7189-7191)TCA>CCA	p.S2397P	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Intron|ANK2_uc011cgb.1_Missense_Mutation_p.S2412P	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2364					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGGAACTGAATCAAAACCTCA	0.502			NA											60	76					0	0	0.00361	0	0
MFSD8	256471	broad.mit.edu	37	4	128863280	128863281	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:128863280_128863281CC>AA	uc003ifp.2	-	6	635_636	c.472_473GG>TT	c.(472-474)GGT>TTT	p.G158F	MFSD8_uc011cgu.1_Missense_Mutation_p.G113F|MFSD8_uc011cgv.1_Intron|MFSD8_uc011cgw.1_Intron|MFSD8_uc011cgx.1_Missense_Mutation_p.G113F	NM_152778	NP_689991	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing	158	Cytoplasmic (Potential).				cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2						GGAAGTAGCACCAGCAGTATAT	0.356			NA											54	96					0	0	0.004672	0	0
INPP4B	8821	broad.mit.edu	37	4	143129683	143129683	+	Splice_Site	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:143129683C>A	uc003iix.3	-	15	1563	c.968_splice	c.e15-1	p.G323_splice	INPP4B_uc003iiw.3_Splice_Site_p.G323_splice|INPP4B_uc011chm.1_Splice_Site|INPP4B_uc011chn.1_Splice_Site_p.G138_splice|INPP4B_uc011cho.1_Splice_Site|INPP4B_uc011chp.1_Splice_Site_p.G194_splice	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,						signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					AAAGAGGACCCTGATGGAAAC	0.303			NA											11	26					0.00136819	0.00142043	0.001368	1	0
ARHGAP10	79658	broad.mit.edu	37	4	148876486	148876486	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:148876486A>G	uc003ilf.2	+	16	1411	c.1411A>G	c.(1411-1413)ATG>GTG	p.M471V	ARHGAP10_uc003ilg.2_Missense_Mutation_p.M120V|ARHGAP10_uc003ilh.2_Missense_Mutation_p.M52V	NM_024605	NP_078881	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	471	Rho-GAP.				apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			skin(2)|pancreas(1)|lung(1)	4	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		AGAGCCTCTCATGACCTATGA	0.348			NA											71	256					0	0	0.00361	0	0
LRBA	987	broad.mit.edu	37	4	151223840	151223840	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:151223840C>A	uc010ipj.2	-	54	8461	c.7987G>T	c.(7987-7989)GAT>TAT	p.D2663Y	LRBA_uc010ipi.2_Missense_Mutation_p.D185Y|LRBA_uc003ils.3_Missense_Mutation_p.D558Y|LRBA_uc003ilt.3_Missense_Mutation_p.D1311Y|LRBA_uc003ilu.3_Missense_Mutation_p.D2652Y|LRBA_uc003ilr.3_Missense_Mutation_p.D83Y	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2663	WD 3.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					AGAGTTGCATCACGTGACCCT	0.423			NA											69	124					3.58576e-35	5.5487e-35	0.00361	1	0
DCHS2	54798	broad.mit.edu	37	4	155156960	155156960	+	Silent	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:155156960G>A	uc003inw.2	-	25	7479	c.7479C>T	c.(7477-7479)CTC>CTT	p.L2493L		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2493	Cadherin 22.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CTTCTTTGTTGAGTTGACTTT	0.353			NA											4	90					0	0	0.009096	0	0
NPY2R	4887	broad.mit.edu	37	4	156135190	156135191	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:156135190_156135191CC>AA	uc003ioq.2	+	2	594_595	c.99_100CC>AA	c.(97-102)GTCCCT>GTAACT	p.P34T	NPY2R_uc003ior.2_Missense_Mutation_p.P34T	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	34	Extracellular (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				GTGAACTGGTCCCTGACCCTGA	0.475			NA											32	71					0	0	0.004672	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156631723	156631723	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:156631723C>G	uc003iov.2	+	7	942	c.406C>G	c.(406-408)CTT>GTT	p.L136V	GUCY1A3_uc003iou.2_Missense_Mutation_p.L136V|GUCY1A3_uc010iqc.2_Missense_Mutation_p.L136V|GUCY1A3_uc003iow.2_Missense_Mutation_p.L136V|GUCY1A3_uc010iqd.2_Missense_Mutation_p.L135V|GUCY1A3_uc003iox.2_Missense_Mutation_p.L136V|GUCY1A3_uc003ioz.2_5'UTR|GUCY1A3_uc003ioy.2_Missense_Mutation_p.L136V|GUCY1A3_uc010iqe.2_Intron|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Missense_Mutation_p.L136V	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	136				VIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLK QSSHCQEAGKRGR -> LSKNLLVKRFLKYVTRKMKTSLGW LEAPLKIFKQLQYPSETEQPLPRSRKKGQ (in Ref. 1).	blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CAAAGAATCTCTTGGTGAAGA	0.388			NA											4	83					0	0	0.001168	0	0
SLC6A18	348932	broad.mit.edu	37	5	1240646	1240646	+	Silent	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:1240646G>A	uc003jby.1	+	7	969	c.846G>A	c.(844-846)AGG>AGA	p.R282R		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	282	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TTGTGCCCAGGAATGACTGCC	0.587			NA											6	38					0	0	0.006214	0	0
KIAA0947	23379	broad.mit.edu	37	5	5473809	5473809	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:5473809G>T	uc003jdm.3	+	16	6583	c.6361G>T	c.(6361-6363)GAT>TAT	p.D2121Y		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	2121										ovary(1)|central_nervous_system(1)	2						ATTTGCCATTGATCTGCTCTG	0.333			NA											11	27					2.32078e-09	2.68797e-09	0.003163	1	0
SEMA5A	9037	broad.mit.edu	37	5	9190417	9190417	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:9190417C>G	uc003jek.2	-	11	1947	c.1235G>C	c.(1234-1236)GGC>GCC	p.G412A		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	412	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						CGCTTCTCTGCCCTGCACCAC	0.522			NA											11	47					0	0	0.003163	0	0
CTNND2	1501	broad.mit.edu	37	5	11098777	11098777	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:11098777G>T	uc003jfa.1	-	15	2692	c.2547C>A	c.(2545-2547)CCC>CCA	p.P849P	CTNND2_uc010itt.2_Silent_p.P758P|CTNND2_uc011cmy.1_Silent_p.P512P|CTNND2_uc011cmz.1_Silent_p.P416P|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.P416P	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	849	ARM 7.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GTGTGAGGTAGGGTTTGACTA	0.562			NA											43	48					7.22619e-39	1.13982e-38	0.00361	1	0
RNASEN	29102	broad.mit.edu	37	5	31406967	31406967	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:31406967C>G	uc003jhg.2	-	33	4299	c.3940G>C	c.(3940-3942)GGA>CGA	p.G1314R	RNASEN_uc003jhh.2_Missense_Mutation_p.G1277R	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	1314	Necessary for interaction with DGCR8 and pri-miRNA processing activity.|DRBM.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						TACCTTGGTCCTTTCCCACAG	0.463			NA											31	82					0	0	0.004878	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33576861	33576861	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:33576861G>T	uc003jia.1	-	19	3433	c.3270C>A	c.(3268-3270)CCC>CCA	p.P1090P	ADAMTS12_uc010iuq.1_Silent_p.P1005P	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1090	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						AAGTGAGGATGGGCTGGGAAG	0.512			NA								HNSCC(64;0.19)			110	198					2.31934e-59	3.9651e-59	0.00361	1	0
IL7R	3575	broad.mit.edu	37	5	35876346	35876346	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:35876346C>A	uc003jjs.2	+	8	1227	c.1138C>A	c.(1138-1140)CCT>ACT	p.P380T	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	380	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			ATGTGACGCCCCTATTCTCTC	0.537			NA											31	69					3.78316e-11	4.51921e-11	0.00623	1	0
HCN1	348980	broad.mit.edu	37	5	45262807	45262807	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:45262807C>A	uc003jok.2	-	8	1914	c.1889G>T	c.(1888-1890)AGG>ATG	p.R630M		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	630	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						CACCATCTCCCTGTCATGTTT	0.448			NA											80	131					2.76863e-45	4.45321e-45	0.00361	1	0
RASGRF2	5924	broad.mit.edu	37	5	80369234	80369234	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:80369234A>G	uc003kha.1	+	5	850	c.850A>G	c.(850-852)ATC>GTC	p.I284V	RASGRF2_uc011ctn.1_RNA|RASGRF2_uc003khb.1_Missense_Mutation_p.I112V	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	284	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		GAAGCCCCCCATCAGCCACGA	0.483			NA											4	29					0	0	0.000978	0	0
EDIL3	10085	broad.mit.edu	37	5	83402547	83402547	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:83402547G>T	uc003kio.1	-	6	990	c.571C>A	c.(571-573)CCC>ACC	p.P191T	EDIL3_uc003kip.1_Missense_Mutation_p.P181T	NM_005711	NP_005702	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like	191	F5/8 type C 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			skin(2)	2		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		GCATAGTAGGGATACCATTTT	0.458			NA											48	139					1.00776e-21	1.37334e-21	0.00361	1	0
PAM	5066	broad.mit.edu	37	5	102343170	102343170	+	Missense_Mutation	SNP	G	G	T	rs148652099		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:102343170G>T	uc003knw.2	+	19	2397	c.2024G>T	c.(2023-2025)GGG>GTG	p.G675V	PAM_uc003kns.2_Missense_Mutation_p.G568V|PAM_uc003knt.2_Missense_Mutation_p.G675V|PAM_uc003knu.2_Missense_Mutation_p.G675V|PAM_uc003knv.2_Missense_Mutation_p.G675V|PAM_uc011cuz.1_Missense_Mutation_p.G578V|PAM_uc003knz.2_5'UTR	NM_000919	NP_000910	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	675	Peptidyl-alpha-hydroxyglycine alpha- amidating lyase (By similarity).|NHL 4.|Intragranular (Potential).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	GAGTCTTCAGGGAGCAGTCCT	0.438			NA											28	66					2.05212e-20	2.75708e-20	0.005524	1	0
FBN2	2201	broad.mit.edu	37	5	127597560	127597560	+	Nonsense_Mutation	SNP	G	G	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:127597560G>C	uc003kuu.2	-	64	8671	c.8232C>G	c.(8230-8232)TAC>TAG	p.Y2744*		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2744					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CCAGTGACAGGTACTGCCCCT	0.438			NA											53	81					0	0	0.00361	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188720	140188720	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:140188720C>A	uc003lhi.2	+	1	2049	c.1948C>A	c.(1948-1950)CTG>ATG	p.L650M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.L650M|PCDHA4_uc011daa.1_Missense_Mutation_p.L650M	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	650	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTACTGGTACTGGTGAAGGA	0.677			NA											43	36					5.73332e-34	8.63779e-34	0.00361	1	0
PCDHA10	56139	broad.mit.edu	37	5	140237084	140237084	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:140237084A>T	uc003lhx.2	+	1	1451	c.1451A>T	c.(1450-1452)CAG>CTG	p.Q484L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.Q484L|PCDHA10_uc011dad.1_Missense_Mutation_p.Q484L	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	484	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGGACGCGCAGGAGAACGCC	0.662			NA											11	30					0	0	0.007413	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502607	140502607	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:140502607C>A	uc003lip.1	+	1	1027	c.1027C>A	c.(1027-1029)CCC>ACC	p.P343T		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	343	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAATGACAATCCCCCAGAACT	0.443			NA											71	212					6.44082e-31	9.38191e-31	0.00361	1	0
PCDHB6	56130	broad.mit.edu	37	5	140531538	140531538	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:140531538C>A	uc003lir.2	+	1	1700	c.1700C>A	c.(1699-1701)TCC>TAC	p.S567Y	PCDHB6_uc011dah.1_Missense_Mutation_p.S431Y	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	567	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGAACGGCTCCGCGCCCTGC	0.721			NA											4	6					0.000602214	0.000629788	0.000602	1	0
PCDHB16	57717	broad.mit.edu	37	5	140563163	140563163	+	Silent	SNP	T	T	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:140563163T>C	uc003liv.2	+	1	2184	c.1029T>C	c.(1027-1029)AAT>AAC	p.N343N	PCDHB16_uc010jfw.1_Silent_p.N15N	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	343	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGAATGACAATCCCCCACAGG	0.517			NA											24	72					0	0	0.008361	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736507	140736507	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:140736507C>T	uc003ljq.1	+	1	1740	c.1740C>T	c.(1738-1740)CGC>CGT	p.R580R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Silent_p.R580R	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	580	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCACCCCGCTCCGCAGATT	0.587			NA											30	103					0	0	0.00361	0	0
PCDH1	5097	broad.mit.edu	37	5	141244523	141244523	+	Missense_Mutation	SNP	A	A	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:141244523A>C	uc003llq.2	-	3	1490	c.1373T>G	c.(1372-1374)CTG>CGG	p.L458R	PCDH1_uc003llp.2_Missense_Mutation_p.L458R|PCDH1_uc011dbf.1_Missense_Mutation_p.L436R	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	458	Extracellular (Potential).|Cadherin 4.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		GGTAGTCTGCAGGAAATACTT	0.557	Ovarian(132;1609 1739 4190 14731 45037)		NA											68	293					0	0	0.00361	0	0
SH3RF2	153769	broad.mit.edu	37	5	145393468	145393468	+	Silent	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:145393468C>A	uc003lnt.2	+	5	1141	c.903C>A	c.(901-903)ATC>ATA	p.I301I	SH3RF2_uc011dbl.1_Silent_p.I301I	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	301							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGTTTTCCATCACAACAGCCT	0.577			NA											108	430					5.01931e-35	7.74601e-35	0.00361	1	0
GRIA1	2890	broad.mit.edu	37	5	153030061	153030061	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:153030061C>G	uc003lva.3	+	4	997	c.632C>G	c.(631-633)GCT>GGT	p.A211G	GRIA1_uc003luy.3_Missense_Mutation_p.A211G|GRIA1_uc003luz.3_Missense_Mutation_p.A116G|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.A131G|GRIA1_uc011dcx.1_Missense_Mutation_p.A142G|GRIA1_uc011dcy.1_Missense_Mutation_p.A221G|GRIA1_uc011dcz.1_Missense_Mutation_p.A221G|GRIA1_uc010jia.1_Missense_Mutation_p.A191G	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	211	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CGCCTCAATGCTATCTTGGGC	0.512			NA											48	56					0	0	0.00361	0	0
GRIA1	2890	broad.mit.edu	37	5	153085295	153085295	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:153085295G>T	uc003lva.3	+	11	1856	c.1491G>T	c.(1489-1491)TTG>TTT	p.L497F	GRIA1_uc003luy.3_Missense_Mutation_p.L497F|GRIA1_uc003luz.3_Missense_Mutation_p.L402F|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.L417F|GRIA1_uc011dcx.1_Missense_Mutation_p.L428F|GRIA1_uc011dcy.1_Missense_Mutation_p.L507F|GRIA1_uc011dcz.1_Missense_Mutation_p.L507F|GRIA1_uc010jia.1_Missense_Mutation_p.L477F	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	497	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CTATCACTTTGGTCCGGGAAG	0.388			NA											4	12					0.00024832	0.000261606	0.009096	1	0
ITK	3702	broad.mit.edu	37	5	156638359	156638359	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:156638359G>T	uc003lwo.1	+	3	387	c.305G>T	c.(304-306)TGG>TTG	p.W102L		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	102	PH.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CGGCAGCGCTGGGTGCTGGCC	0.488	Esophageal Squamous(70;1378 1469 8785 19883)		NA	T	SYK	peripheral T-cell lymphoma								28	95					1.22674e-20	1.65205e-20	0.00874	1	0
ATP10B	23120	broad.mit.edu	37	5	160076224	160076224	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:160076224C>T	uc003lym.1	-	8	1562	c.715G>A	c.(715-717)GTG>ATG	p.V239M	ATP10B_uc003lyp.2_Missense_Mutation_p.V239M|ATP10B_uc011deg.1_Missense_Mutation_p.V283M|ATP10B_uc003lyo.2_Missense_Mutation_p.V211M	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	239	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTCTCACACACGATGGTATTG	0.408			NA											17	81					0	0	0.00333	0	0
ODZ2	57451	broad.mit.edu	37	5	167645863	167645863	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:167645863T>A	uc010jjd.2	+	23	4940	c.4940T>A	c.(4939-4941)ATC>AAC	p.I1647N	ODZ2_uc003lzr.3_Missense_Mutation_p.I1417N|ODZ2_uc003lzt.3_Missense_Mutation_p.I1020N|ODZ2_uc010jje.2_Missense_Mutation_p.I911N	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		GACAACCAGATCATCACCCTC	0.532			NA											153	496					0	0	0.00361	0	0
CCDC99	54908	broad.mit.edu	37	5	169023609	169023609	+	Silent	SNP	A	A	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:169023609A>G	uc003mae.3	+	8	1215	c.936A>G	c.(934-936)GAA>GAG	p.E312E	CCDC99_uc010jjj.2_Silent_p.E241E|CCDC99_uc011deq.1_Silent_p.E129E|CCDC99_uc010jjk.2_Silent_p.E38E	NM_017785	NP_060255	Q96EA4	SPDLY_HUMAN	coiled-coil domain containing 99	312	Potential.				cell division|establishment of mitotic spindle orientation|mitotic metaphase plate congression|mitotic prometaphase|protein localization to kinetochore	condensed chromosome outer kinetochore|cytosol|microtubule organizing center|nucleus|spindle pole	kinetochore binding|protein binding			ovary(1)|liver(1)	2	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTCAAACTGAATTTGAGCAGC	0.348			NA											26	89					0	0	0.003755	0	0
F13A1	2162	broad.mit.edu	37	6	6197479	6197479	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:6197479C>A	uc003mwv.2	-	9	1316	c.1193G>T	c.(1192-1194)AGC>ATC	p.S398I	F13A1_uc011dib.1_Missense_Mutation_p.S335I	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	398					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CTGGGGGGTGCTGTCCACAGC	0.478			NA											40	98					4.75955e-12	5.77007e-12	0.00361	1	0
CAGE1	285782	broad.mit.edu	37	6	7355286	7355286	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:7355286G>T	uc003mxi.2	-	8	2484	c.1763C>A	c.(1762-1764)TCC>TAC	p.S588Y	CAGE1_uc003mxh.2_RNA|CAGE1_uc003mxj.2_Missense_Mutation_p.S541Y|CAGE1_uc003mxk.1_Missense_Mutation_p.S506Y	NM_205864	NP_995586	Q8TC20	CAGE1_HUMAN	cancer antigen 1	724											0	Ovarian(93;0.0418)					TGCAATCTGGGAGTGGGATAT	0.308			NA											47	57					2.92391e-54	4.89604e-54	0.00361	1	0
TDP2	51567	broad.mit.edu	37	6	24666767	24666767	+	Missense_Mutation	SNP	C	C	T	rs143844222	by1000genomes	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:24666767C>T	uc003nej.2	-	2	263	c.238G>A	c.(238-240)GAG>AAG	p.E80K	TDP2_uc003nei.2_5'UTR|TDP2_uc010jpu.1_Missense_Mutation_p.E80K|ACOT13_uc010jpv.2_5'Flank|ACOT13_uc003nek.2_5'Flank	NM_016614	NP_057698	O95551	TYDP2_HUMAN	TRAF and TNF receptor-associated protein	80					cell surface receptor linked signaling pathway|double-strand break repair	PML body	5'-tyrosyl-DNA phosphodiesterase activity|magnesium ion binding|nuclease activity|protein binding|transcription corepressor activity			ovary(1)|lung(1)	2						GTCTTGGGCTCAGAGATGGTT	0.602			NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					22	235					0	0	0.009535	0	0
HIST1H2AJ	8331	broad.mit.edu	37	6	27782248	27782248	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:27782248C>T	uc003njn.1	-	1	271	c.271G>A	c.(271-273)GAT>AAT	p.D91N	HIST1H2BM_uc003njo.2_5'Flank	NM_021066	NP_066544	Q99878	H2A1J_HUMAN	histone cluster 1, H2aj	91					nucleosome assembly	nucleosome|nucleus	DNA binding				0						AGCTCCTCATCGTTGCGGATG	0.612			NA											13	23					0	0	0.00278	0	0
SLC26A8	116369	broad.mit.edu	37	6	35918953	35918953	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:35918953G>T	uc003olm.2	-	19	2570	c.2459C>A	c.(2458-2460)TCA>TAA	p.S820*	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Nonsense_Mutation_p.S402*|SLC26A8_uc003oln.2_Nonsense_Mutation_p.S820*|SLC26A8_uc003oll.2_Nonsense_Mutation_p.S715*	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	820	Interaction with RACGAP1.|Cytoplasmic (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						GTCTGTTTCTGAGTAGGTTTC	0.552			NA											92	97					1.9643e-79	3.45112e-79	0.00361	1	0
LRFN2	57497	broad.mit.edu	37	6	40360626	40360626	+	Missense_Mutation	SNP	A	A	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:40360626A>C	uc003oph.1	-	3	1891	c.1426T>G	c.(1426-1428)TTC>GTC	p.F476V		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	476	Fibronectin type-III.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					TTGACCACGAAGGCCTTGTTG	0.547			NA											16	24					0	0	0.007413	0	0
LRFN2	57497	broad.mit.edu	37	6	40399650	40399650	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:40399650G>T	uc003oph.1	-	2	1668	c.1203C>A	c.(1201-1203)GGC>GGA	p.G401G		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	401	Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					TCTTGCTGGAGCCAGTGATGT	0.657			NA											7	5					9.31168e-06	1.01276e-05	0.001855	1	0
TREML2	79865	broad.mit.edu	37	6	41162245	41162245	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:41162245G>A	uc010jxm.1	-	3	882	c.703C>T	c.(703-705)CTC>TTC	p.L235F		NM_024807	NP_079083	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid	235	Extracellular (Potential).				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					CTGGTGCTGAGGTCCCCAGAC	0.622			NA											8	9					0	0	0.00308	0	0
TCTE1	202500	broad.mit.edu	37	6	44253930	44253930	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:44253930A>T	uc003oxi.2	-	3	773	c.617T>A	c.(616-618)CTC>CAC	p.L206H	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	206										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GCCCGGCCGGAGCTGGGCCGG	0.672			NA											5	6					0	0	0.004482	0	0
COL21A1	81578	broad.mit.edu	37	6	55922481	55922481	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:55922481G>A	uc003pcs.2	-	30	3080	c.2848C>T	c.(2848-2850)CCG>TCG	p.P950S	COL21A1_uc010jzz.2_Missense_Mutation_p.P335S|COL21A1_uc011dxg.1_Missense_Mutation_p.P323S|COL21A1_uc011dxh.1_Missense_Mutation_p.P301S|COL21A1_uc003pcr.2_Missense_Mutation_p.P307S	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	950					cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TTTCTGAACGGATCTCTTCTG	0.473			NA											33	45					0	0	0.00623	0	0
RFPL4B	442247	broad.mit.edu	37	6	112671067	112671067	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:112671067C>T	uc003pvx.1	+	3	469	c.157C>T	c.(157-159)CGA>TGA	p.R53*		NM_001013734	NP_001013756	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	53	RING-type.						zinc ion binding				0		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		CCCCTTGTGTCGAGACGTGGT	0.463			NA											3	38					0	0	0.009096	0	0
NCOA7	135112	broad.mit.edu	37	6	126210971	126210971	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:126210971G>T	uc010kes.2	+	11	2220	c.1771G>T	c.(1771-1773)GTA>TTA	p.V591L	NCOA7_uc003qae.3_Missense_Mutation_p.V591L|NCOA7_uc003qah.2_Missense_Mutation_p.V580L|NCOA7_uc003qai.2_Missense_Mutation_p.V591L|NCOA7_uc010ket.2_Missense_Mutation_p.V476L	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	591					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		GCCCCTCCCGGTAAAACTGAA	0.468			NA											20	34					3.5997e-14	4.49765e-14	0.002299	1	0
PDE10A	10846	broad.mit.edu	37	6	165806140	165806140	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:165806140G>A	uc003qun.2	-	17	1862	c.1621C>T	c.(1621-1623)CTT>TTT	p.L541F	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.L471F|PDE10A_uc003quo.2_Missense_Mutation_p.L551F	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	541					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	CCCACCTCAAGGTCTGTGAAA	0.458	Esophageal Squamous(22;308 615 5753 12038 40624)		NA											109	312					0	0	0.00361	0	0
CARD11	84433	broad.mit.edu	37	7	2976689	2976689	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:2976689G>T	uc003smv.2	-	9	1727	c.1323C>A	c.(1321-1323)GAC>GAA	p.D441E		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	441	Potential.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GGTTGTTGCTGTCCTTGGAGA	0.672			NA	Mis		DLBCL								14	12					7.05477e-17	9.032e-17	0.00499	1	0
MEOX2	4223	broad.mit.edu	37	7	15652213	15652213	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:15652213C>A	uc003stc.2	-	3	995	c.714G>T	c.(712-714)AGG>AGT	p.R238S	MEOX2_uc011jxw.1_Missense_Mutation_p.R238S	NM_005924	NP_005915	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	238	Homeobox.				blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		ACTTCATCCGCCTGTTTTGGA	0.438	Esophageal Squamous(140;197 1769 16409 18257 29929)		NA											19	93					7.45023e-12	8.97485e-12	0.010504	1	0
ABCB5	340273	broad.mit.edu	37	7	20698196	20698196	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:20698196T>A	uc003suw.3	+	5	815	c.269T>A	c.(268-270)ATT>AAT	p.I90N	ABCB5_uc010kuh.2_Missense_Mutation_p.I535N|ABCB5_uc003suv.3_Missense_Mutation_p.I90N|ABCB5_uc011jyi.1_Missense_Mutation_p.I90N	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	90	ABC transporter 1.|Extracellular (Potential).				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						AGGATCGCAATTGCTCGTGCC	0.438			NA											33	145					0	0	0.00874	0	0
GPNMB	10457	broad.mit.edu	37	7	23286420	23286420	+	Translation_Start_Site	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:23286420C>T	uc003swc.2	+	1	105	c.-56C>T	c.(-58--54)GACGG>GATGG		GPNMB_uc003swa.2_Translation_Start_Site|GPNMB_uc003swb.2_Translation_Start_Site|GPNMB_uc011jyy.1_Translation_Start_Site|GPNMB_uc011jyz.1_Translation_Start_Site	NM_001005340	NP_001005340	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb isoform a						negative regulation of cell proliferation	melanosome				ovary(3)|breast(2)	5			GBM - Glioblastoma multiforme(13;0.154)			TCTTGGTGGACGGGCCCAGAG	0.493			NA											19	22					0	0	0.008871	0	0
ANLN	54443	broad.mit.edu	37	7	36462361	36462361	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:36462361T>A	uc003tff.2	+	14	2623	c.2419T>A	c.(2419-2421)TCA>ACA	p.S807T	ANLN_uc011kaz.1_Missense_Mutation_p.S719T|ANLN_uc003tfg.2_Missense_Mutation_p.S770T|ANLN_uc010kxe.2_Missense_Mutation_p.S769T	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	807	Localization to the cleavage furrow.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						AGTTACTTTGTCAGAAATCCG	0.388			NA											30	153					0	0	0.003271	0	0
POU6F2	11281	broad.mit.edu	37	7	39379247	39379247	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:39379247C>T	uc003thb.1	+	5	560	c.518C>T	c.(517-519)TCA>TTA	p.S173L	POU6F2_uc010kxo.2_Missense_Mutation_p.S165L	NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	173	Gln-rich.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						GTAGCTACCTCATCCCTGAAC	0.393			NA											13	22					0	0	0.003163	0	0
GLI3	2737	broad.mit.edu	37	7	42063147	42063147	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:42063147C>A	uc011kbh.1	-	10	1508	c.1417G>T	c.(1417-1419)GAG>TAG	p.E473*	GLI3_uc011kbg.1_Nonsense_Mutation_p.E414*	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	473					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						ACTTCAGGCTCCTGTTTGCTT	0.547			NA							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				41	51					6.17242e-35	9.44893e-35	0.00361	1	0
CDC14C	168448	broad.mit.edu	37	7	48965406	48965406	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:48965406C>T	uc010kyv.1	+	1	1250	c.1138C>T	c.(1138-1140)CAG>TAG	p.Q380*		NR_003595				SubName: Full=Putative uncharacterized protein MGC26484;												0						GAATCAAGACCAGCAAGAACC	0.458			NA											9	22					0	0	0.001855	0	0
DDC	1644	broad.mit.edu	37	7	50563117	50563117	+	Splice_Site	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:50563117T>A	uc003tpf.3	-	9	963	c.877_splice	c.e9-1	p.F293_splice	DDC_uc010kza.2_Splice_Site_p.F208_splice|DDC_uc003tpg.3_Splice_Site_p.F293_splice	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid						cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	ATCTGCAAACTGCCAAAGAAC	0.313			NA											12	37					0	0	0.00245	0	0
ZNF735	730291	broad.mit.edu	37	7	63674397	63674397	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:63674397C>A	uc011kdn.1	+	3	173	c.173C>A	c.(172-174)ACT>AAT	p.T58N		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	58	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACAGGTATGACTGTCTCTAAG	0.279			NA											9	40					0.000274275	0.000288418	0.004482	1	0
MAGI2	9863	broad.mit.edu	37	7	78131003	78131003	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:78131003G>T	uc003ugx.2	-	5	1110	c.856C>A	c.(856-858)CAG>AAG	p.Q286K	MAGI2_uc003ugy.2_Missense_Mutation_p.Q286K|MAGI2_uc011kgr.1_Missense_Mutation_p.Q118K|MAGI2_uc011kgs.1_Missense_Mutation_p.Q123K	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	286						cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TCATCCATCTGCTCCTTCAGC	0.507			NA											25	101					1.88708e-17	2.44337e-17	0.008361	1	0
CACNA2D1	781	broad.mit.edu	37	7	81964549	81964549	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:81964549C>A	uc003uhr.1	-	3	452	c.196G>T	c.(196-198)GAT>TAT	p.D66Y		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	66	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	GTATACAAATCTTGATATTTC	0.353			NA											16	97					0.000229342	0.000242508	0.001882	1	0
PCLO	27445	broad.mit.edu	37	7	82585203	82585203	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:82585203G>T	uc003uhx.2	-	5	5355	c.5066C>A	c.(5065-5067)ACA>AAA	p.T1689K	PCLO_uc003uhv.2_Missense_Mutation_p.T1689K	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1620					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ATACAAACTTGTTTTTTTCTG	0.428			NA											15	22					2.5808e-16	3.28204e-16	0.006122	1	0
SAMD9	54809	broad.mit.edu	37	7	92734038	92734038	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:92734038C>A	uc003umf.2	-	3	1629	c.1373G>T	c.(1372-1374)AGC>ATC	p.S458I	SAMD9_uc003umg.2_Missense_Mutation_p.S458I	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	458						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TGCTACTCGGCTTTCTTTGTA	0.383			NA											9	42					1.08611e-07	1.2208e-07	0.000978	1	0
PPP1R9A	55607	broad.mit.edu	37	7	94540239	94540239	+	Missense_Mutation	SNP	C	C	T	rs140508899		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:94540239C>T	uc003unp.2	+	2	1096	c.814C>T	c.(814-816)CAC>TAC	p.H272Y	PPP1R9A_uc010lfj.2_Missense_Mutation_p.H272Y|PPP1R9A_uc011kif.1_Missense_Mutation_p.H272Y|PPP1R9A_uc003unq.2_Missense_Mutation_p.H272Y|PPP1R9A_uc011kig.1_Missense_Mutation_p.H272Y	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	272						cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AGAGGATGCTCACAAGAGTAA	0.458			NA								HNSCC(28;0.073)			32	38					0	0	0.009718	0	0
MUC17	140453	broad.mit.edu	37	7	100682038	100682038	+	Silent	SNP	A	A	G	rs142442389	byFrequency	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:100682038A>G	uc003uxp.1	+	3	7394	c.7341A>G	c.(7339-7341)CCA>CCG	p.P2447P	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2447	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|39.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCAGCATACCAACCTCACCTC	0.537			NA											14	505					0	0	0.003163	0	0
PIK3CG	5294	broad.mit.edu	37	7	106509787	106509787	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:106509787G>A	uc003vdv.3	+	2	1866	c.1781G>A	c.(1780-1782)AGT>AAT	p.S594N	PIK3CG_uc003vdu.2_Missense_Mutation_p.S594N|PIK3CG_uc003vdw.2_Missense_Mutation_p.S594N	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	594					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						AAGCTATTTAGTTCAGTGAAA	0.428			NA											32	80					0	0	0.005524	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518041	113518041	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:113518041G>A	uc010ljy.1	-	4	3137	c.3106C>T	c.(3106-3108)CAA>TAA	p.Q1036*		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	1036					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						TATAGTGATTGCCCAGAGCTT	0.398			NA											215	310					0	0	0.00361	0	0
HYAL4	23553	broad.mit.edu	37	7	123509169	123509169	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:123509169G>T	uc003vlc.2	+	3	1480	c.842G>T	c.(841-843)CGG>CTG	p.R281L	HYAL4_uc011knz.1_Missense_Mutation_p.R281L	NM_012269	NP_036401	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	281	Extracellular (Potential).				fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			skin(1)	1						TCCAAATTTCGGGTGCATGAA	0.443			NA											19	67					6.21321e-17	7.97246e-17	0.00278	1	0
GRM8	2918	broad.mit.edu	37	7	126173844	126173844	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:126173844C>T	uc003vlr.2	-	8	1903	c.1592G>A	c.(1591-1593)GGG>GAG	p.G531E	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.G531E|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	531	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GCAAGGGACCCCTTTCACCGT	0.552			NA								HNSCC(24;0.065)			16	86					0	0	0.001882	0	0
KEL	3792	broad.mit.edu	37	7	142639572	142639572	+	Silent	SNP	C	C	A	rs140592001	byFrequency	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:142639572C>A	uc003wcb.2	-	18	2196	c.1986G>T	c.(1984-1986)CTG>CTT	p.L662L		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	662	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					CCAGGCTGGGCAGGACAGTCT	0.587			NA											12	35					9.16793e-09	1.04908e-08	0.00499	1	0
OR2F2	135948	broad.mit.edu	37	7	143633237	143633237	+	Silent	SNP	A	A	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:143633237A>G	uc011ktv.1	+	1	912	c.912A>G	c.(910-912)CTA>CTG	p.L304L		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	304	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					GGCATAAACTATTAGAGAAAT	0.418			NA											16	63					0	0	0.001882	0	0
ZNF398	57541	broad.mit.edu	37	7	148876178	148876178	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:148876178G>T	uc003wfl.2	+	6	1489	c.1214G>T	c.(1213-1215)AGG>ATG	p.R405M	ZNF398_uc011kul.1_Missense_Mutation_p.R234M|ZNF398_uc011kum.1_Missense_Mutation_p.R410M	NM_170686	NP_733787	Q8TD17	ZN398_HUMAN	zinc finger 398 isoform a	405	C2H2-type 3.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00143)			CACTGTGCCAGGACTTTTACT	0.582			NA											59	54					4.83248e-46	7.83906e-46	0.00361	1	0
MLL3	58508	broad.mit.edu	37	7	151919678	151919678	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:151919678G>T	uc003wla.2	-	21	3632	c.3413C>A	c.(3412-3414)CCC>CAC	p.P1138H	MLL3_uc003wkz.2_Missense_Mutation_p.P199H	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1138	PHD-type 6.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AGGCATATAGGGTCTGCACAT	0.398	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								16	62					3.41278e-10	3.99324e-10	0.00499	1	0
ESYT2	57488	broad.mit.edu	37	7	158529746	158529746	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:158529746C>A	uc003wob.1	-	19	2539	c.2473G>T	c.(2473-2475)GAT>TAT	p.D825Y	ESYT2_uc003wny.1_RNA|ESYT2_uc003wnz.1_Missense_Mutation_p.D264Y|ESYT2_uc003woa.1_Missense_Mutation_p.D402Y	NM_020728	NP_065779	A0FGR8	ESYT2_HUMAN	family with sequence similarity 62 (C2 domain	853	C2 3.					integral to membrane|plasma membrane				central_nervous_system(2)|kidney(1)	3						TACCTTTGATCAAACACTGGA	0.463			NA											65	315					3.25985e-27	4.64183e-27	0.00361	1	0
TMEM66	51669	broad.mit.edu	37	8	29927564	29927564	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:29927564C>T	uc003xhs.2	-	3	478	c.294G>A	c.(292-294)AAG>AAA	p.K98K	TMEM66_uc003xht.2_Silent_p.K98K|TMEM66_uc003xhu.2_Silent_p.K62K|TMEM66_uc003xhv.2_5'UTR	NM_016127	NP_057211	Q96BY9	TMM66_HUMAN	transmembrane protein 66 precursor	98						integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(542;0.0993)|Kidney(114;0.119)		CTAAGTCCGTCTTACATTCCC	0.318			NA											11	163					0	0	0.000978	0	0
ADAM32	203102	broad.mit.edu	37	8	39027483	39027483	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:39027483G>T	uc003xmt.3	+	10	1127	c.882G>T	c.(880-882)ATG>ATT	p.M294I	ADAM32_uc011lch.1_Missense_Mutation_p.M301I|ADAM32_uc003xmu.3_Missense_Mutation_p.M294I	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	294	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			CTGGAACAATGTGTATTACTC	0.234			NA											64	38					1.11883e-47	1.83052e-47	0.00361	1	0
ANK1	286	broad.mit.edu	37	8	41552150	41552150	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:41552150G>C	uc003xok.2	-	28	3371	c.3287C>G	c.(3286-3288)CCG>CGG	p.P1096R	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.P412R|ANK1_uc003xoi.2_Missense_Mutation_p.P1096R|ANK1_uc003xoj.2_Missense_Mutation_p.P1096R|ANK1_uc003xol.2_Missense_Mutation_p.P1096R|ANK1_uc003xom.2_Missense_Mutation_p.P1137R	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1096					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GGCATTCTCCGGGAACGTTGC	0.632			NA											7	4					0	0	0.008291	0	0
PRKDC	5591	broad.mit.edu	37	8	48855770	48855770	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:48855770T>A	uc003xqi.2	-	10	1022	c.965A>T	c.(964-966)CAG>CTG	p.Q322L	PRKDC_uc003xqj.2_Missense_Mutation_p.Q322L|PRKDC_uc011ldh.1_Missense_Mutation_p.Q322L	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	322	HEAT 1.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TTGTGGTACCTGTTTCAGAAA	0.353	Esophageal Squamous(79;1091 1253 12329 31680 40677)		NA						NHEJ					22	8					0	0	0.009535	0	0
PXDNL	137902	broad.mit.edu	37	8	52370158	52370158	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:52370158G>T	uc003xqu.3	-	9	983	c.882C>A	c.(880-882)AAC>AAA	p.N294K		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	294	Ig-like C2-type 1.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				ACTCTCTGGTGTTTCGGATCA	0.443			NA											204	134					5.58888e-140	1.02284e-139	0.00361	1	0
XKR4	114786	broad.mit.edu	37	8	56436303	56436303	+	Silent	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:56436303A>T	uc003xsf.2	+	3	1502	c.1470A>T	c.(1468-1470)CCA>CCT	p.P490P		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	490	Helical; (Potential).					integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			TTGCCATTCCAGCGCTGTGTG	0.453			NA											38	22					0	0	0.00361	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68208800	68208800	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:68208800C>A	uc003xxo.1	-	5	895	c.505G>T	c.(505-507)GGG>TGG	p.G169W		NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	169					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			AGTACAGTCCCTTCATGAATT	0.318			NA											38	78					5.04308e-16	6.39911e-16	0.00623	1	0
C8orf84	157869	broad.mit.edu	37	8	73993266	73993266	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:73993266C>G	uc003xzf.2	-	2	602	c.397G>C	c.(397-399)GGG>CGG	p.G133R		NM_153225	NP_694957	Q8IVN8	RPESP_HUMAN	RPE-spondin precursor	133					immune response	extracellular region	polysaccharide binding|scavenger receptor activity				0						TAGGTGTGCCCGCAGTCCTGG	0.582			NA											18	260					0	0	0.005443	0	0
PI15	51050	broad.mit.edu	37	8	75737519	75737519	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:75737519T>C	uc003yal.2	+	2	214	c.35T>C	c.(34-36)CTG>CCG	p.L12P	uc003yak.1_Intron|PI15_uc003yam.2_Missense_Mutation_p.L12P	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	12						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			AGTGCACTCCTGTTCTCCCTT	0.468			NA											157	262					0	0	0.00361	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767417	77767417	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:77767417A>G	uc003yav.2	+	10	8512	c.8125A>G	c.(8125-8127)ACA>GCA	p.T2709A	ZFHX4_uc003yau.1_Missense_Mutation_p.T2754A|ZFHX4_uc003yaw.1_Missense_Mutation_p.T2709A	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2709						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TACAGTGTCAACACCTGTTAG	0.383			NA								HNSCC(33;0.089)			28	43					0	0	0.005524	0	0
CNGB3	54714	broad.mit.edu	37	8	87738759	87738759	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:87738759C>T	uc003ydx.2	-	3	384	c.338G>A	c.(337-339)AGC>AAC	p.S113N		NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	113	Cytoplasmic (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						AAATGCTCACCTGTTTGGACC	0.458			NA											68	122					0	0	0.00361	0	0
NBN	4683	broad.mit.edu	37	8	90982638	90982638	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:90982638C>G	uc003yej.1	-	7	960	c.850G>C	c.(850-852)GAC>CAC	p.D284H	NBN_uc003yei.1_Missense_Mutation_p.D202H|NBN_uc011lgb.1_Missense_Mutation_p.D284H	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	284					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			TTCTGACAGTCAGGAATTAAG	0.333			NA						Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				44	99					0	0	0.00361	0	0
KIAA1429	25962	broad.mit.edu	37	8	95522735	95522735	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:95522735C>A	uc003ygo.1	-	14	3549	c.3536G>T	c.(3535-3537)CGT>CTT	p.R1179L	KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1179					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			AACACAAATACGCCGTAACAT	0.423			NA											73	133					1.32003e-40	2.09955e-40	0.00361	1	0
CSMD3	114788	broad.mit.edu	37	8	113392679	113392679	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:113392679G>T	uc003ynu.2	-	38	6197	c.6038C>A	c.(6037-6039)ACA>AAA	p.T2013K	CSMD3_uc003yns.2_Missense_Mutation_p.T1215K|CSMD3_uc003ynt.2_Missense_Mutation_p.T1973K|CSMD3_uc011lhx.1_Missense_Mutation_p.T1909K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2013	Extracellular (Potential).|CUB 11.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATGGGGTATTGTTGTTCCTGA	0.318			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			46	101					7.91745e-34	1.1897e-33	0.00361	1	0
TRPS1	7227	broad.mit.edu	37	8	116617221	116617221	+	Silent	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:116617221T>A	uc003ynz.2	-	3	1395	c.936A>T	c.(934-936)TCA>TCT	p.S312S	TRPS1_uc011lhy.1_Silent_p.S316S|TRPS1_uc003yny.2_Silent_p.S325S|TRPS1_uc010mcy.2_Silent_p.S312S	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	312					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			ATGTTCCACCTGAAGTCACCT	0.463			NA							Langer-Giedion_syndrome				53	92					0	0	0.00361	0	0
ENPP2	5168	broad.mit.edu	37	8	120580440	120580440	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:120580440C>A	uc003yot.1	-	22	2192	c.2106G>T	c.(2104-2106)ATG>ATT	p.M702I	ENPP2_uc011lic.1_Missense_Mutation_p.M240I|ENPP2_uc003yor.1_Missense_Mutation_p.M337I|ENPP2_uc003yos.1_Missense_Mutation_p.M754I|ENPP2_uc010mdd.1_Missense_Mutation_p.M727I	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	702					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			ACATTGGAACCATATTGGTTA	0.313	Melanoma(20;305 879 2501 4818 31020)		NA											151	209					8.31651e-93	1.47935e-92	0.00361	1	0
FER1L6	654463	broad.mit.edu	37	8	125015557	125015557	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:125015557C>A	uc003yqw.2	+	13	1876	c.1670C>A	c.(1669-1671)CCG>CAG	p.P557Q	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	557	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ACCACTCACCCGGAGAAGCCA	0.522			NA											50	87					3.69863e-55	6.28548e-55	0.00361	1	0
KIAA0196	9897	broad.mit.edu	37	8	126061389	126061389	+	Silent	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:126061389C>A	uc003yrt.2	-	19	2567	c.2238G>T	c.(2236-2238)GCG>GCT	p.A746A	KIAA0196_uc011lir.1_Silent_p.A598A|KIAA0196_uc003yru.1_Silent_p.A320A	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	746					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CATCCATGGTCGCTCCCAACT	0.398			NA											59	112					2.47556e-37	3.87273e-37	0.00361	1	0
ADCY8	114	broad.mit.edu	37	8	131795974	131795974	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:131795974G>T	uc003ytd.3	-	17	3487	c.3231C>A	c.(3229-3231)ATC>ATA	p.I1077I	ADCY8_uc010mds.2_Silent_p.I946I	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	1077	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AATGCTTGTTGATCTCCTGTA	0.502			NA								HNSCC(32;0.087)			90	168					5.30932e-60	9.10397e-60	0.00361	1	0
KCNK9	51305	broad.mit.edu	37	8	140631035	140631035	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:140631035C>A	uc003yvf.1	-	2	655	c.591G>T	c.(589-591)TTG>TTT	p.L197F	KCNK9_uc003yvg.1_Missense_Mutation_p.L197F|KCNK9_uc003yve.1_RNA	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	197						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			CAATGGTAGTCAACGTGATGA	0.577			NA											29	72					1.8613e-05	2.01288e-05	0.004289	1	0
CNTLN	54875	broad.mit.edu	37	9	17298192	17298192	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:17298192G>C	uc003zmz.2	+	7	1014	c.988G>C	c.(988-990)GAA>CAA	p.E330Q	CNTLN_uc003zmx.3_Missense_Mutation_p.E330Q|CNTLN_uc003zmy.2_Missense_Mutation_p.E330Q|CNTLN_uc010mio.2_Missense_Mutation_p.E9Q	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	330						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		GCACAGGAAGGAACTGCAGGA	0.408			NA											37	41					0	0	0.00623	0	0
GNE	10020	broad.mit.edu	37	9	36246104	36246104	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:36246104C>T	uc010mlh.2	-	3	755	c.540G>A	c.(538-540)TTG>TTA	p.L180L	CLTA_uc003zzf.1_Intron|GNE_uc010mlg.2_Silent_p.L180L|GNE_uc011lpl.1_Silent_p.L121L|GNE_uc010mli.2_Silent_p.L211L|GNE_uc010mlj.2_Silent_p.L175L	NM_005476	NP_005467	Q9Y223	GLCNE_HUMAN	UDP-N-acetylglucosamine-2-epimerase/N-	180	UDP-N-acetylglucosamine 2-epimerase.				cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity				0			STAD - Stomach adenocarcinoma(86;0.228)			GGCAGCCTGCCAAAAGGATGC	0.483	GBM(184;106 2118 20004 35750 50727)		NA											5	136					0	0	0.001984	0	0
TRPM3	80036	broad.mit.edu	37	9	73235267	73235267	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:73235267C>T	uc004aid.2	-	15	2062	c.1818G>A	c.(1816-1818)TTG>TTA	p.L606L	TRPM3_uc004ahu.2_Silent_p.L436L|TRPM3_uc004ahv.2_Silent_p.L408L|TRPM3_uc004ahw.2_Silent_p.L478L|TRPM3_uc004ahx.2_Silent_p.L465L|TRPM3_uc004ahy.2_Silent_p.L468L|TRPM3_uc004ahz.2_Silent_p.L455L|TRPM3_uc004aia.2_Silent_p.L453L|TRPM3_uc004aib.2_Silent_p.L443L|TRPM3_uc004aic.2_Silent_p.L606L	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	631	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						TTCCTCGCCTCAAGGGAATAT	0.348			NA											70	322					0	0	0.00361	0	0
TRPM3	80036	broad.mit.edu	37	9	73235278	73235278	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:73235278C>T	uc004aid.2	-	15	2051	c.1807G>A	c.(1807-1809)GAT>AAT	p.D603N	TRPM3_uc004ahu.2_Missense_Mutation_p.D433N|TRPM3_uc004ahv.2_Missense_Mutation_p.D405N|TRPM3_uc004ahw.2_Missense_Mutation_p.D475N|TRPM3_uc004ahx.2_Missense_Mutation_p.D462N|TRPM3_uc004ahy.2_Missense_Mutation_p.D465N|TRPM3_uc004ahz.2_Missense_Mutation_p.D452N|TRPM3_uc004aia.2_Missense_Mutation_p.D450N|TRPM3_uc004aib.2_Missense_Mutation_p.D440N|TRPM3_uc004aic.2_Missense_Mutation_p.D603N	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	628	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						AAGGGAATATCATCCTGTAAT	0.318			NA											59	316					0	0	0.00361	0	0
OSTF1	26578	broad.mit.edu	37	9	77752469	77752469	+	Missense_Mutation	SNP	A	A	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:77752469A>C	uc004ajv.3	+	8	635	c.424A>C	c.(424-426)ACA>CCA	p.T142P	OSTF1_uc004ajw.3_Missense_Mutation_p.T99P|OSTF1_uc004ajx.3_Missense_Mutation_p.T145P	NM_012383	NP_036515	Q92882	OSTF1_HUMAN	osteoclast stimulating factor 1	142	ANK 3.				ossification|signal transduction	cytoplasm	identical protein binding			skin(1)	1						GTTGGGAGATACAGCTTTGCA	0.393			NA											14	67					0	0	0.006122	0	0
TLE4	7091	broad.mit.edu	37	9	82242321	82242321	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:82242321G>T	uc004ald.2	+	6	1176	c.327G>T	c.(325-327)CGG>CGT	p.R109R	TLE4_uc004alc.2_Silent_p.R116R|TLE4_uc010mpr.2_5'UTR|TLE4_uc004ale.2_5'UTR|TLE4_uc011lsq.1_Intron|TLE4_uc010mps.2_Silent_p.R109R|TLE4_uc004alf.2_Silent_p.R54R	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						CTGTGGAACGGGCCAAGCAGG	0.453			NA											226	240					4.96009e-127	8.99115e-127	0.00361	1	0
TLE4	7091	broad.mit.edu	37	9	82336678	82336678	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:82336678G>T	uc004ald.2	+	18	2785	c.1936G>T	c.(1936-1938)GGA>TGA	p.G646*	TLE4_uc004alc.2_Nonsense_Mutation_p.G621*|TLE4_uc010mpr.2_Nonsense_Mutation_p.G500*|TLE4_uc004ale.2_Nonsense_Mutation_p.G258*|TLE4_uc011lsq.1_Nonsense_Mutation_p.G589*|TLE4_uc010mps.2_Nonsense_Mutation_p.G545*|TLE4_uc004alf.2_Nonsense_Mutation_p.G560*	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						CCACACAGATGGAGCCAGCTG	0.473			NA											52	58					5.80444e-35	8.9095e-35	0.00361	1	0
C9orf79	286234	broad.mit.edu	37	9	90501607	90501607	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:90501607G>T	uc004app.3	+	4	2240	c.2205G>T	c.(2203-2205)GAG>GAT	p.E735D	C9orf79_uc004apo.1_Missense_Mutation_p.E547D	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	735						integral to membrane				ovary(3)	3						AAGACAAGGAGGCAGAAGGTG	0.547			NA											41	41					4.49093e-37	7.00635e-37	0.00361	1	0
Unknown	0	broad.mit.edu	37	9	90746326	90746326	+	Silent	SNP	C	C	G	rs149069834	by1000genomes	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:90746326C>G	uc011lti.1	-	4	1655	c.1626G>C	c.(1624-1626)GCG>GCC	p.A542A						SubName: Full=cDNA FLJ59639;												NA						CCTCAGAGGTCGCCCCCAGAA	0.517			NA											17	66					0	0	0.00278	0	0
NOL8	55035	broad.mit.edu	37	9	95072852	95072852	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:95072852C>A	uc004arv.2	-	9	2915	c.2578G>T	c.(2578-2580)GGC>TGC	p.G860C	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Missense_Mutation_p.G92C|NOL8_uc011ltw.1_Missense_Mutation_p.G792C	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	860					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						CCAGCTCTGCCCTCAAACTGA	0.388			NA											123	456					1.9257e-63	3.33204e-63	0.00361	1	0
C9orf102	375748	broad.mit.edu	37	9	98678647	98678647	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:98678647G>T	uc004avt.3	+	6	1510	c.1122G>T	c.(1120-1122)AAG>AAT	p.K374N	C9orf102_uc010mrx.1_RNA|C9orf102_uc011lum.1_Missense_Mutation_p.K76N|C9orf102_uc010mry.1_Missense_Mutation_p.K76N|C9orf102_uc010mrz.2_Missense_Mutation_p.K185N	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	374					DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				TTGCCAAAAAGATGTCTGGCT	0.453			NA											40	49					2.68985e-26	3.79236e-26	0.00361	1	0
CDC14B	8555	broad.mit.edu	37	9	99285924	99285924	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:99285924C>G	uc004awj.2	-	10	1482	c.1030G>C	c.(1030-1032)GTC>CTC	p.V344L	CDC14B_uc004awk.2_Missense_Mutation_p.V344L|CDC14B_uc004awl.2_RNA|CDC14B_uc004awi.2_Missense_Mutation_p.V307L	NM_033331	NP_201588	O60729	CC14B_HUMAN	CDC14 homolog B isoform 2	344	B.				activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				CAGATCCTGACCCACGCAATG	0.527			NA											20	63					0	0	0.003954	0	0
ZNF510	22869	broad.mit.edu	37	9	99521121	99521121	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:99521121A>G	uc004awn.1	-	6	2180	c.1991T>C	c.(1990-1992)TTA>TCA	p.L664S	ZNF510_uc004awo.1_Missense_Mutation_p.L664S	NM_014930	NP_055745	Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	664					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				CTTCTTACATAATTTCCCATA	0.363			NA											38	88					0	0	0.00361	0	0
TEX10	54881	broad.mit.edu	37	9	103088600	103088600	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:103088600C>A	uc004bas.2	-	9	2178	c.1963G>T	c.(1963-1965)GGG>TGG	p.G655W	TEX10_uc011lvf.1_Missense_Mutation_p.G494W|TEX10_uc011lvg.1_Missense_Mutation_p.G658W	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	655						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		TGCAGTATCCCGATAAGCATG	0.418			NA											38	137					5.34276e-22	7.33344e-22	0.00361	1	0
TMEFF1	8577	broad.mit.edu	37	9	103204311	103204311	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:103204311G>C	uc004bay.1	+	1	124	c.91G>C	c.(91-93)GTG>CTG	p.V31L	C9orf30_uc004baw.2_Missense_Mutation_p.V31L|C9orf30_uc004bax.2_RNA	NM_003692	NP_003683	Q8IYR6	TEFF1_HUMAN	transmembrane protein with EGF-like and two	Error:Variant_position_missing_in_Q8IYR6_after_alignment					multicellular organismal development	integral to membrane|plasma membrane					0		Acute lymphoblastic leukemia(62;0.0452)				GTATAAATATGTGCTGGAATG	0.448			NA											12	37					0	0	0.001855	0	0
GRIN3A	116443	broad.mit.edu	37	9	104448937	104448937	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:104448937G>T	uc004bbp.1	-	2	1846	c.1245C>A	c.(1243-1245)AGC>AGA	p.S415R	GRIN3A_uc004bbq.1_Missense_Mutation_p.S415R	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	415	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	AGTTCATCGTGCTGGGAATGA	0.478			NA											62	240					8.07507e-42	1.29519e-41	0.00361	1	0
KLF4	9314	broad.mit.edu	37	9	110248160	110248160	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:110248160C>A	uc004bdh.2	-	4	2008	c.1387G>T	c.(1387-1389)GCC>TCC	p.A463S	KLF4_uc004bdf.1_Missense_Mutation_p.A388S|KLF4_uc004bdg.2_Missense_Mutation_p.A438S	NM_004235	NP_004226	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	472	C2H2-type 2.				fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(2)|lung(1)	3						TCTGAGCGGGCGAATTTCCAT	0.493			NA											7	40					3.86212e-05	4.15305e-05	0.008291	1	0
RABGAP1	23637	broad.mit.edu	37	9	125748687	125748687	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:125748687A>T	uc011lzh.1	+	4	713	c.579A>T	c.(577-579)GAA>GAT	p.E193D	RABGAP1_uc004bnl.3_RNA|RABGAP1_uc004bnm.1_Missense_Mutation_p.E193D	NM_012197	NP_036329	Q9Y3P9	RBGP1_HUMAN	RAB GTPase activating protein 1	193	PID.				cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			ovary(3)|kidney(2)	5						ATGTGTCTGAAGGAATTGTGA	0.403			NA											183	214					0	0	0.00361	0	0
NR6A1	2649	broad.mit.edu	37	9	127300525	127300525	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:127300525G>A	uc004bor.1	-	6	848	c.670C>T	c.(670-672)CAA>TAA	p.Q224*	NR6A1_uc004boq.1_Nonsense_Mutation_p.Q219*|NR6A1_uc010mwq.1_Nonsense_Mutation_p.Q220*	NM_033334	NP_201591	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	224	Sufficient for interaction with UIMC1 (By similarity).				cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						GGTATATATTGGTAATGTGGA	0.488	Esophageal Squamous(192;272 2884 6208 20560)		NA											74	69					0	0	0.00361	0	0
COQ4	51117	broad.mit.edu	37	9	131087468	131087468	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:131087468G>T	uc004bur.3	+	3	596	c.249G>T	c.(247-249)AAG>AAT	p.K83N	TRUB2_uc004buq.1_5'Flank|COQ4_uc011max.1_Missense_Mutation_p.K83N|COQ4_uc004bus.2_Missense_Mutation_p.K59N|COQ4_uc010mxy.2_Missense_Mutation_p.K59N	NM_016035	NP_057119	Q9Y3A0	COQ4_HUMAN	coenzyme Q4 homolog precursor	83					ubiquinone biosynthetic process	mitochondrial inner membrane					0						GCACCCTGAAGGTCCTCAGGG	0.527			NA											17	26					6.94344e-10	8.10778e-10	0.006122	1	0
NUP188	23511	broad.mit.edu	37	9	131731775	131731775	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:131731775G>T	uc004bws.1	+	10	916	c.894G>T	c.(892-894)CAG>CAT	p.Q298H		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	298					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						AGTTTGCGCAGGATGGGCTTA	0.423			NA											48	162					2.76378e-25	3.86794e-25	0.00361	1	0
QSOX2	169714	broad.mit.edu	37	9	139115927	139115927	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:139115927C>T	uc010nbi.2	-	4	548	c.510G>A	c.(508-510)CAG>CAA	p.Q170Q		NM_181701	NP_859052	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2 precursor	170	Thioredoxin.				cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			ovary(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		CAATCATCGTCTGTCTGACTG	0.627			NA											16	25					0	0	0.007413	0	0
QSOX2	169714	broad.mit.edu	37	9	139115958	139115958	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:139115958C>T	uc010nbi.2	-	4	517	c.479G>A	c.(478-480)GGA>GAA	p.G160E		NM_181701	NP_859052	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2 precursor	160	Thioredoxin.				cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			ovary(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		TCGGTCAGGTCCTGCCGGAAG	0.657			NA											11	21					0	0	0.00245	0	0
PPP2R3B	28227	broad.mit.edu	37	X	308043	308043	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:308043C>A	uc004cpg.2	-	4	844	c.643G>T	c.(643-645)GCC>TCC	p.A215S	PPP2R3B_uc011mha.1_Missense_Mutation_p.A54S	NM_013239	NP_037371	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'',	215					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ACGAACTTGGCCGCGTCGTCG	0.617			NA											5	29					0.00116845	0.00121527	0.001168	1	0
MXRA5	25878	broad.mit.edu	37	X	3235270	3235270	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:3235270G>T	uc004crg.3	-	6	6609	c.6452C>A	c.(6451-6453)ACC>AAC	p.T2151N		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2151	Ig-like C2-type 6.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CCGCGGGGAGGTGCCCGTGAT	0.711			NA											18	4					8.24728e-16	1.04186e-15	0.004656	1	0
FRMPD4	9758	broad.mit.edu	37	X	12735148	12735148	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:12735148C>A	uc004cuz.1	+	15	3076	c.2570C>A	c.(2569-2571)GCC>GAC	p.A857D	FRMPD4_uc011mij.1_Missense_Mutation_p.A849D	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	857					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						CCCACCAGCGCCGAAGGCAAG	0.572			NA											76	63					5.64992e-62	9.71718e-62	0.00361	1	0
TLR8	51311	broad.mit.edu	37	X	12940213	12940213	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:12940213G>T	uc004cve.2	+	2	3122	c.3054G>T	c.(3052-3054)CTG>CTT	p.L1018L	TLR8_uc004cvd.2_Silent_p.L1036L	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	1018	Cytoplasmic (Potential).|TIR.				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						GGCAAACTCTGAGAAATGTGG	0.443			NA											8	242					2.17888e-05	2.35187e-05	0.006214	1	0
NHS	4810	broad.mit.edu	37	X	17746185	17746185	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:17746185T>A	uc004cxx.2	+	6	4234	c.3896T>A	c.(3895-3897)GTG>GAG	p.V1299E	NHS_uc011mix.1_Missense_Mutation_p.V1320E|NHS_uc004cxy.2_Missense_Mutation_p.V1143E|NHS_uc004cxz.2_Missense_Mutation_p.V1122E|NHS_uc004cya.2_Missense_Mutation_p.V1022E	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	1299						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					CCTGAATCTGTGGATGTAATC	0.438			NA											67	89					0	0	0.00361	0	0
FAM48B1	100130302	broad.mit.edu	37	X	24381889	24381889	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:24381889G>A	uc011mjx.1	+	1	1012	c.1012G>A	c.(1012-1014)GGA>AGA	p.G338R		NM_001136234	NP_001129706			hypothetical protein LOC100130302											kidney(1)	1						AGACCCTTTTGGATTTGCGTT	0.527			NA											90	59					0	0	0.00361	0	0
MAGEB2	4113	broad.mit.edu	37	X	30237624	30237624	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:30237624A>T	uc004dbz.2	+	2	1030	c.927A>T	c.(925-927)GAA>GAT	p.E309D		NM_002364	NP_002355	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	309	MAGE.						protein binding			ovary(1)	1						ATTACGAAGAAGCTTTGAAAG	0.498			NA											38	12					0	0	0.007835	0	0
FAM47A	158724	broad.mit.edu	37	X	34148608	34148608	+	Silent	SNP	A	A	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:34148608A>T	uc004ddg.2	-	1	1821	c.1788T>A	c.(1786-1788)TCT>TCA	p.S596S		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	596										ovary(4)|central_nervous_system(1)	5						GAAGAGAGTCAGAAACGCACT	0.453			NA											7	75					0	0	0.00308	0	0
TSPAN7	7102	broad.mit.edu	37	X	38525426	38525426	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:38525426G>T	uc004deg.3	+	2	202	c.133G>T	c.(133-135)GGC>TGC	p.G45C	TSPAN7_uc011mkj.1_Missense_Mutation_p.G71C|TSPAN7_uc011mkk.1_Missense_Mutation_p.G62C|TSPAN7_uc004deh.2_5'UTR	NM_004615	NP_004606	P41732	TSN7_HUMAN	tetraspanin 7	45	Extracellular (Potential).				interspecies interaction between organisms	integral to plasma membrane				ovary(1)	1						ACTTACTCTGGGCACCTATAT	0.502			NA											47	37					1.67211e-32	2.46712e-32	0.00361	1	0
ZNF157	7712	broad.mit.edu	37	X	47271905	47271905	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:47271905G>T	uc004dhr.1	+	4	502	c.433G>T	c.(433-435)GAG>TAG	p.E145*		NM_003446	NP_003437	P51786	ZN157_HUMAN	zinc finger protein 157	145					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGCCTTCCATGAGAAAACAGG	0.388			NA											109	75					6.95862e-65	1.21139e-64	0.00361	1	0
FTSJ1	24140	broad.mit.edu	37	X	48340805	48340805	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:48340805C>A	uc004djo.1	+	10	993	c.670C>A	c.(670-672)CAG>AAG	p.Q224K	FTSJ1_uc004djl.2_Missense_Mutation_p.Q222K|FTSJ1_uc004djm.2_Missense_Mutation_p.Q224K|FTSJ1_uc004djn.1_Missense_Mutation_p.Q222K|FTSJ1_uc004djp.1_Missense_Mutation_p.Q222K|FTSJ1_uc011mlw.1_Missense_Mutation_p.Q87K	NM_012280	NP_036412	Q9UET6	RRMJ1_HUMAN	FtsJ homolog 1 isoform a	224					RNA methylation|rRNA processing		methyltransferase activity|nucleic acid binding				0						AGATTTCAACCAGCTGGATGG	0.582			NA											6	45					8.12818e-05	8.67513e-05	0.001984	1	0
ZXDB	158586	broad.mit.edu	37	X	57620678	57620678	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:57620678G>T	uc004dvd.2	+	1	2410	c.2197G>T	c.(2197-2199)GAC>TAC	p.D733Y		NM_007157	NP_009088	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	733					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						GCTAACAGTGGACACAGATGC	0.502			NA											22	17					7.38237e-10	8.60272e-10	0.00632	1	0
ZXDA	7789	broad.mit.edu	37	X	57935364	57935364	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:57935364C>T	uc004dve.2	-	1	1704	c.1491G>A	c.(1489-1491)CTG>CTA	p.L497L		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	497	C2H2-type 8.|Required for interaction with ZXDC.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TGTGGCCTTTCAGATGTTCGG	0.542			NA											24	20					0	0	0.00632	0	0
FAM123B	139285	broad.mit.edu	37	X	63411404	63411404	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:63411404G>T	uc004dvo.2	-	2	2036	c.1763C>A	c.(1762-1764)GCT>GAT	p.A588D		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	588					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CCTGGCATGAGCTTCTCGGGC	0.607			NA											4	100					0.000602214	0.000629788	0.000602	1	0
TEX11	56159	broad.mit.edu	37	X	69964040	69964040	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:69964040T>A	uc004dyl.2	-	11	929	c.767A>T	c.(766-768)AAG>ATG	p.K256M	TEX11_uc004dym.2_Missense_Mutation_p.K241M	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	256							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					AGTAGATTTCTTATCCATCTT	0.229			NA											15	10					0	0	0.002299	0	0
NLGN3	54413	broad.mit.edu	37	X	70375176	70375176	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:70375176C>T	uc004dzd.1	+	4	890	c.690C>T	c.(688-690)GTC>GTT	p.V230V	NLGN3_uc010nlb.1_Silent_p.V190V|NLGN3_uc004dzb.2_Silent_p.V210V|NLGN3_uc004dzc.2_Silent_p.V93V|NLGN3_uc011mps.1_Silent_p.V190V|NLGN3_uc004dze.2_Silent_p.V28V|NLGN3_uc011mpr.1_Silent_p.V190V	NM_018977	NP_061850	Q9NZ94	NLGN3_HUMAN	neuroligin 3	230	Extracellular (Potential).				neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			ovary(1)	1	Renal(35;0.156)					ATGGCAATGTCATCGTCATCA	0.542	Esophageal Squamous(103;760 1488 16849 22250 40351)		NA											36	199					0	0	0.00361	0	0
NLGN3	54413	broad.mit.edu	37	X	70375182	70375182	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:70375182C>T	uc004dzd.1	+	4	896	c.696C>T	c.(694-696)GTC>GTT	p.V232V	NLGN3_uc010nlb.1_Silent_p.V192V|NLGN3_uc004dzb.2_Silent_p.V212V|NLGN3_uc004dzc.2_Silent_p.V95V|NLGN3_uc011mps.1_Silent_p.V192V|NLGN3_uc004dze.2_Silent_p.V30V|NLGN3_uc011mpr.1_Silent_p.V192V	NM_018977	NP_061850	Q9NZ94	NLGN3_HUMAN	neuroligin 3	232	Extracellular (Potential).				neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			ovary(1)	1	Renal(35;0.156)					ATGTCATCGTCATCACCCTCA	0.537	Esophageal Squamous(103;760 1488 16849 22250 40351)		NA											41	198					0	0	0.00361	0	0
NLGN3	54413	broad.mit.edu	37	X	70375185	70375185	+	Silent	SNP	C	C	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:70375185C>T	uc004dzd.1	+	4	899	c.699C>T	c.(697-699)ATC>ATT	p.I233I	NLGN3_uc010nlb.1_Silent_p.I193I|NLGN3_uc004dzb.2_Silent_p.I213I|NLGN3_uc004dzc.2_Silent_p.I96I|NLGN3_uc011mps.1_Silent_p.I193I|NLGN3_uc004dze.2_Silent_p.I31I|NLGN3_uc011mpr.1_Silent_p.I193I	NM_018977	NP_061850	Q9NZ94	NLGN3_HUMAN	neuroligin 3	233	Extracellular (Potential).				neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			ovary(1)	1	Renal(35;0.156)					TCATCGTCATCACCCTCAACT	0.532	Esophageal Squamous(103;760 1488 16849 22250 40351)		NA											44	196					0	0	0.00361	0	0
MAGEE2	139599	broad.mit.edu	37	X	75003586	75003586	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:75003586A>G	uc004ecj.1	-	1	1486	c.1301T>C	c.(1300-1302)GTA>GCA	p.V434A		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	434	MAGE 2.									ovary(1)|skin(1)	2						CTTTCTCCCTACATCCACACT	0.453			NA											11	231					0	0	0.001855	0	0
TAF9B	51616	broad.mit.edu	37	X	77388927	77388927	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:77388927G>A	uc004eda.2	-	6	571	c.500C>T	c.(499-501)TCT>TTT	p.S167F		NM_015975	NP_057059	Q9HBM6	TAF9B_HUMAN	transcription associated factor 9B	167					negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell growth|transcription initiation, DNA-dependent	transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding				0						ATTTGGGACAGACACCGTTTG	0.418			NA											15	534					0	0	0.008871	0	0
CYLC1	1538	broad.mit.edu	37	X	83129105	83129105	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:83129105G>T	uc004eei.1	+	4	1410	c.1389G>T	c.(1387-1389)AAG>AAT	p.K463N	CYLC1_uc004eeh.1_Missense_Mutation_p.K462N	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	463	6.				cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						ATGAAAAGAAGGGGAAGAAAG	0.353			NA											37	37					2.61675e-31	3.8312e-31	0.003214	1	0
CPXCR1	53336	broad.mit.edu	37	X	88009116	88009117	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:88009116_88009117GG>TT	uc004efd.3	+	3	960_961	c.701_702GG>TT	c.(700-702)AGG>ATT	p.R234I	CPXCR1_uc004efc.3_Missense_Mutation_p.R234I	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	234						intracellular	zinc ion binding			ovary(3)	3						GCTATTGTGAGGTCTGTGCTCT	0.361			NA											22	28					0	0	0.004672	0	0
TCEAL6	158931	broad.mit.edu	37	X	101395859	101395859	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:101395859C>A	uc004eiq.2	-	3	606	c.445G>T	c.(445-447)GCT>TCT	p.A149S		NM_001006938	NP_001006939	Q6IPX3	TCAL6_HUMAN	transcription elongation factor A (SII)-like 6	149					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						TCCTCCTGAGCCCTTGACACA	0.517			NA											127	84					2.48536e-91	4.40728e-91	0.00361	1	0
CT47B1	643311	broad.mit.edu	37	X	120008777	120008777	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:120008777T>A	uc011muc.1	-	1	1003	c.748A>T	c.(748-750)ACC>TCC	p.T250S		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	250											0						TCCTCTGAGGTCGGTTCCTCT	0.552			NA											17	8					0	0	0.00278	0	0
ODZ1	10178	broad.mit.edu	37	X	123518364	123518364	+	Silent	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:123518364G>T	uc004euj.2	-	29	6460	c.6396C>A	c.(6394-6396)CGC>CGA	p.R2132R	ODZ1_uc011muj.1_Silent_p.R2138R|ODZ1_uc010nqy.2_Silent_p.R2139R	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2132	Extracellular (Potential).|YD 16.				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						ATATTACCATGCGGCCCACAT	0.398			NA											178	129					9.38108e-128	1.70592e-127	0.00361	1	0
RAP2C	57826	broad.mit.edu	37	X	131351048	131351048	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:131351048G>T	uc004ewp.2	-	2	1033	c.249C>A	c.(247-249)AGC>AGA	p.S83R	uc004ewr.1_5'Flank|RAP2C_uc004ewo.2_Missense_Mutation_p.S17R|RAP2C_uc010nrk.2_RNA|RAP2C_uc004ewq.3_Missense_Mutation_p.S83R	NM_021183	NP_067006	Q9Y3L5	RAP2C_HUMAN	RAP2C, member of RAS oncogene family precursor	83					negative regulation of cell migration|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of protein tyrosine kinase activity	recycling endosome membrane	GTP binding|GTPase activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GATTAACCAGGCTATAAACCA	0.468			NA											3	52					0.00909568	0.00927435	0.009096	1	0
SPANXC	64663	broad.mit.edu	37	X	140335779	140335779	+	Silent	SNP	G	G	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:140335779G>A	uc004fbk.2	-	2	221	c.165C>T	c.(163-165)TAC>TAT	p.Y55Y	SPANXC_uc004fbl.2_RNA	NM_022661	NP_073152	Q9NY87	SPNXC_HUMAN	sperm protein associated with the nucleus, X	55						cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)					CGTTCCTCCTGTAGCGAACCA	0.507			NA											5	144					0	0	0.004482	0	0
TMLHE	55217	broad.mit.edu	37	X	154774874	154774874	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:154774874T>A	uc004fnn.2	-	2	230	c.64A>T	c.(64-66)ATA>TTA	p.I22L	TMLHE_uc004fno.2_Missense_Mutation_p.I22L|TMLHE_uc004fnp.3_Missense_Mutation_p.I22L	NM_018196	NP_060666	Q9NVH6	TMLH_HUMAN	trimethyllysine hydroxylase, epsilon	22					carnitine biosynthetic process	mitochondrial matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|trimethyllysine dioxygenase activity			ovary(1)	1	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Succinic acid(DB00139)|Vitamin C(DB00126)	GCCGGATATATGACTCCTCCC	0.468			NA											126	508					0	0	0.00361	0	0
VPS13D	55187	broad.mit.edu	37	1	12422832	12422833	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:12422832_12422833insC	uc001atv.2	+	51	10339_10340	c.10198_10199insC	c.(10198-10200)GCCfs	p.A3400fs	VPS13D_uc001atw.2_Frame_Shift_Ins_p.A3375fs|VPS13D_uc001atx.2_Frame_Shift_Ins_p.A2587fs	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3399				A -> T (in Ref. 6; CAE46021).	protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GGTCATCTTTGCCCCCCGTTAC	0.426			NA											14	849	---	---	---	---	NA	NA	NA	NA	NA
CSF3R	1441	broad.mit.edu	37	1	36935322	36935323	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:36935322_36935323insG	uc001caw.1	-	11	1582_1583	c.1404_1405insC	c.(1402-1407)CCCAGCfs	p.P468fs	CSF3R_uc001cat.1_Frame_Shift_Ins_p.P31fs|CSF3R_uc009vvc.1_Frame_Shift_Ins_p.P31fs|CSF3R_uc001cau.1_5'UTR|CSF3R_uc001cav.1_Frame_Shift_Ins_p.P468fs|CSF3R_uc001cax.1_Frame_Shift_Ins_p.P468fs|CSF3R_uc001cay.1_Frame_Shift_Ins_p.P468fs	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	468_469	Extracellular (Potential).|Fibronectin type-III 4.				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TTGCTCGCGCTGGGGGGGCCCA	0.634			NA											8	205	---	---	---	---	NA	NA	NA	NA	NA
FOXJ3	22887	broad.mit.edu	37	1	42657204	42657205	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:42657204_42657205insG	uc001che.2	-	11	1432_1433	c.1120_1121insC	c.(1120-1122)CAGfs	p.Q374fs	FOXJ3_uc001chf.2_Frame_Shift_Ins_p.Q374fs|FOXJ3_uc001chg.2_Frame_Shift_Ins_p.Q374fs|FOXJ3_uc001chh.1_Frame_Shift_Ins_p.Q340fs	NM_014947	NP_055762	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	374					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)	2	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TGTGTGCATCTGGGGGTGAGAC	0.584			NA											7	906	---	---	---	---	NA	NA	NA	NA	NA
FAM151A	338094	broad.mit.edu	37	1	55081756	55081757	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:55081756_55081757insG	uc001cxn.2	-	3	483_484	c.351_352insC	c.(349-354)CCCACTfs	p.P117fs	ACOT11_uc001cxm.1_Intron	NM_176782	NP_788954	Q8WW52	F151A_HUMAN	hypothetical protein LOC338094	117_118						integral to membrane					0						CTGTAGATAGTGGGGGGGTGTG	0.594			NA											13	248	---	---	---	---	NA	NA	NA	NA	NA
FGGY	55277	broad.mit.edu	37	1	59812016	59812017	+	Frame_Shift_Ins	INS	-	-	G	rs145440779	by1000genomes	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:59812016_59812017insG	uc001czi.3	+	4	623_624	c.411_412insG	c.(409-414)GTCGGGfs	p.V137fs	FGGY_uc001czg.2_Frame_Shift_Ins_p.V25fs|FGGY_uc001czh.2_RNA|FGGY_uc009wac.2_Frame_Shift_Ins_p.V137fs|FGGY_uc001czj.3_Frame_Shift_Ins_p.V137fs|FGGY_uc001czk.3_Frame_Shift_Ins_p.V25fs|FGGY_uc001czl.3_Intron	NM_018291	NP_060761	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	137_138					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(1)	1	all_cancers(7;7.36e-05)					TCCAGTACGTCGGGGGGGTGAT	0.5			NA											14	215	---	---	---	---	NA	NA	NA	NA	NA
EPHX4	253152	broad.mit.edu	37	1	92511121	92511122	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:92511121_92511122insG	uc001don.2	+	4	612_613	c.508_509insG	c.(508-510)TGGfs	p.W170fs		NM_173567	NP_775838	Q8IUS5	EPHX4_HUMAN	abhydrolase domain containing 7	170						integral to membrane	hydrolase activity			central_nervous_system(1)	1						TGGCCATGACTGGGGGGGCATG	0.386	GBM(140;473 1857 5172 22066 49719)		NA											10	350	---	---	---	---	NA	NA	NA	NA	NA
F3	2152	broad.mit.edu	37	1	95001694	95001695	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:95001694_95001695insC	uc001dqr.2	-	3	417_418	c.238_239insG	c.(238-240)AAAfs	p.K80fs	F3_uc001dqp.2_RNA|F3_uc001dqq.2_RNA|F3_uc001dqs.2_Frame_Shift_Ins_p.K80fs	NM_001993	NP_001984	P13726	TF_HUMAN	coagulation factor III precursor	80	Extracellular (Potential).				activation of caspase activity|activation of plasma proteins involved in acute inflammatory response|anti-apoptosis|blood coagulation, extrinsic pathway|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of protein kinase B signaling cascade	extracellular matrix|extracellular space|integral to membrane	cell surface binding|phospholipid binding|protease binding			central_nervous_system(1)	1		all_lung(203;0.00106)|Lung NSC(277;0.00475)		all cancers(265;0.0232)|Epithelial(280;0.121)	Coagulation factor VIIa(DB00036)	GTAAAAGCATTTGCTTTTCCAA	0.446	Melanoma(40;358 1339 15970 39161)		NA											13	340	---	---	---	---	NA	NA	NA	NA	NA
ITGA10	8515	broad.mit.edu	37	1	145534121	145534122	+	Frame_Shift_Ins	INS	-	-	C	rs147270843		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:145534121_145534122insC	uc001eoa.2	+	14	1702_1703	c.1626_1627insC	c.(1624-1629)GAACCCfs	p.E542fs	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Frame_Shift_Ins_p.E411fs|ITGA10_uc009wiw.2_Frame_Shift_Ins_p.E399fs|ITGA10_uc010oyw.1_Frame_Shift_Ins_p.E487fs	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	542_543	Extracellular (Potential).|FG-GAP 6.				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTCAGCCAGAACCCCCCCAGGA	0.554			NA											8	244	---	---	---	---	NA	NA	NA	NA	NA
TDRD10	126668	broad.mit.edu	37	1	154493907	154493908	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:154493907_154493908insC	uc009wow.2	+	6	1159_1160	c.321_322insC	c.(319-324)AGGCCCfs	p.R107fs	TDRD10_uc001ffd.2_Frame_Shift_Ins_p.R107fs|TDRD10_uc001ffe.2_Frame_Shift_Ins_p.R28fs	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	107_108							nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CAAGCAAAAGGCCCCCCAAGAG	0.52			NA											8	301	---	---	---	---	NA	NA	NA	NA	NA
ASH1L	55870	broad.mit.edu	37	1	155491185	155491186	+	Frame_Shift_Ins	INS	-	-	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:155491185_155491186insT	uc009wqq.2	-	2	605_606	c.125_126insA	c.(124-126)AACfs	p.N42fs	ASH1L_uc001fkt.2_Frame_Shift_Ins_p.N42fs|ASH1L_uc009wqr.1_Frame_Shift_Ins_p.N42fs	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	42					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CCTCCTTTGTGTTTTTTTCTAG	0.431			NA											9	1277	---	---	---	---	NA	NA	NA	NA	NA
KIRREL	55243	broad.mit.edu	37	1	158058202	158058203	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:158058202_158058203insC	uc001frn.3	+	8	1406_1407	c.1002_1003insC	c.(1000-1005)AATCCCfs	p.N334fs	KIRREL_uc010pib.1_Frame_Shift_Ins_p.N234fs|KIRREL_uc009wsq.2_Frame_Shift_Ins_p.N170fs|KIRREL_uc001fro.3_Frame_Shift_Ins_p.N132fs	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	334_335	Extracellular (Potential).|Ig-like C2-type 4.					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					GGGTTGGGAATCCCCCCCTCAC	0.416			NA											8	270	---	---	---	---	NA	NA	NA	NA	NA
CD1C	911	broad.mit.edu	37	1	158262099	158262100	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:158262099_158262100insC	uc001fru.2	+	3	846_847	c.554_555insC	c.(553-555)TGCfs	p.C185fs	CD1C_uc001frv.2_5'UTR	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	185	Extracellular (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					AGAAGCACTTGCCCCCGATTTC	0.45			NA											7	2000	---	---	---	---	NA	NA	NA	NA	NA
OR10Z1	128368	broad.mit.edu	37	1	158576486	158576487	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:158576486_158576487insG	uc010pio.1	+	1	258_259	c.258_259insG	c.(256-261)GCTGGGfs	p.A86fs		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	86_87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					CTGGCCTGGCTGGGGGGGACCA	0.554			NA											23	867	---	---	---	---	NA	NA	NA	NA	NA
OR10Z1	128368	broad.mit.edu	37	1	158577072	158577073	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:158577072_158577073insC	uc010pio.1	+	1	844_845	c.844_845insC	c.(844-846)ACCfs	p.T282fs		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					TACTGTAGTGACCCCCCTCCTT	0.46			NA											10	1276	---	---	---	---	NA	NA	NA	NA	NA
XCL2	6846	broad.mit.edu	37	1	168510352	168510352	+	Frame_Shift_Del	DEL	A	A	-			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:168510352delA	uc001gfn.3	-	3	216	c.183delT	c.(181-183)ATTfs	p.I61fs		NM_003175	NP_003166	Q9UBD3	XCL2_HUMAN	chemokine (C motif) ligand 2 precursor	61					blood circulation|chemotaxis|immune response|signal transduction	extracellular space	chemokine activity			ovary(1)	1	all_hematologic(923;0.215)					CACGTTTGGTAATAAAACTGT	0.468			NA											22	406	---	---	---	---	NA	NA	NA	NA	NA
XCL1	6375	broad.mit.edu	37	1	168550290	168550290	+	Frame_Shift_Del	DEL	T	T	-			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:168550290delT	uc001gfo.1	+	3	197	c.177delT	c.(175-177)ATTfs	p.I59fs		NM_002995	NP_002986	P47992	XCL1_HUMAN	chemokine (C motif) ligand 1	59					CD4-positive, alpha-beta T cell proliferation|CD8-positive, alpha-beta T cell proliferation|cell-cell signaling|cellular response to interleukin-4|cellular response to transforming growth factor beta stimulus|immunoglobulin production in mucosal tissue|lymphocyte chemotaxis|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell cytokine production|negative regulation of T-helper 1 cell activation|negative regulation of transcription, DNA-dependent|neutrophil chemotaxis|positive regulation of activated T cell proliferation|positive regulation of B cell chemotaxis|positive regulation of granzyme A production|positive regulation of granzyme B production|positive regulation of interleukin-10 production|positive regulation of natural killer cell chemotaxis|positive regulation of neutrophil chemotaxis|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell chemotaxis|positive regulation of T cell cytokine production|positive regulation of T cell mediated cytotoxicity|positive regulation of thymocyte migration|positive regulation of transforming growth factor-beta production|regulation of inflammatory response|release of sequestered calcium ion into cytosol|response to virus|T-helper 1 cell cytokine production|T-helper 2 cell cytokine production	extracellular space	chemokine activity|protein homodimerization activity				0	all_hematologic(923;0.208)					TGCGTTACAGTTTTATTACCA	0.463			NA											10	97	---	---	---	---	NA	NA	NA	NA	NA
PAPPA2	60676	broad.mit.edu	37	1	176762723	176762724	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:176762723_176762724insC	uc001gkz.2	+	20	6212_6213	c.5048_5049insC	c.(5047-5049)ATCfs	p.I1683fs	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1683	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TTGTGTGTAATCCCCCCCAGTG	0.47			NA											19	469	---	---	---	---	NA	NA	NA	NA	NA
ATP2B4	493	broad.mit.edu	37	1	203667345	203667346	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:203667345_203667346insC	uc001gzw.2	+	3	1138_1139	c.254_255insC	c.(253-255)ATCfs	p.I85fs	ATP2B4_uc001gzv.2_Frame_Shift_Ins_p.I85fs|ATP2B4_uc009xaq.2_Frame_Shift_Ins_p.I85fs	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	85	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CACAACGTGATCCCCCCCAAAA	0.48			NA											9	181	---	---	---	---	NA	NA	NA	NA	NA
GOLT1A	127845	broad.mit.edu	37	1	204170835	204170836	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:204170835_204170836insC	uc001has.1	-	3	407_408	c.221_222insG	c.(220-222)GGTfs	p.G74fs	GOLT1A_uc001hat.1_Frame_Shift_Ins_p.G74fs	NM_198447	NP_940849	Q6ZVE7	GOT1A_HUMAN	golgi transport 1 homolog A	74	Helical; Name=3; (Potential).				protein transport|vesicle-mediated transport	Golgi membrane|integral to membrane					0	all_cancers(21;0.0165)|Breast(84;0.179)|all_epithelial(62;0.242)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.244)			CGATAACCACACCCCCCAGGAG	0.545			NA											8	571	---	---	---	---	NA	NA	NA	NA	NA
CR2	1380	broad.mit.edu	37	1	207642043	207642044	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:207642043_207642044insC	uc001hfw.2	+	3	711_712	c.617_618insC	c.(616-618)GTCfs	p.V206fs	CR2_uc001hfv.2_Frame_Shift_Ins_p.V206fs|CR2_uc009xch.2_Frame_Shift_Ins_p.V206fs|CR2_uc009xci.1_5'Flank	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	206	Sushi 3.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						TGGAGTGCTGTCCCCCCCACAT	0.396			NA											13	335	---	---	---	---	NA	NA	NA	NA	NA
C1orf107	27042	broad.mit.edu	37	1	210014266	210014267	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:210014266_210014267insC	uc001hhr.1	+	8	1427_1428	c.1351_1352insC	c.(1351-1353)TCCfs	p.S451fs	C1orf107_uc009xcu.1_Frame_Shift_Ins_p.S166fs	NM_014388	NP_055203	Q68CQ4	DIEXF_HUMAN	digestive-organ expansion factor homolog	451					multicellular organismal development	nucleus					0				OV - Ovarian serous cystadenocarcinoma(81;0.0367)		CCTCATTGCTTCCCCCCTGGGC	0.465			NA											7	324	---	---	---	---	NA	NA	NA	NA	NA
SIPA1L2	57568	broad.mit.edu	37	1	232650637	232650638	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr1:232650637_232650638insG	uc001hvg.2	-	1	606_607	c.448_449insC	c.(448-450)CAAfs	p.Q150fs		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	150					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				AAGTCCTCTTTGGGGGGAATGG	0.49			NA											7	525	---	---	---	---	NA	NA	NA	NA	NA
ZEB1	6935	broad.mit.edu	37	10	31809832	31809833	+	Frame_Shift_Ins	INS	-	-	G	rs35708848		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:31809832_31809833insG	uc001ivs.3	+	7	1632_1633	c.1569_1570insG	c.(1567-1572)GAAGGGfs	p.E523fs	ZEB1_uc001ivr.3_Frame_Shift_Ins_p.E305fs|ZEB1_uc010qee.1_Frame_Shift_Ins_p.E305fs|ZEB1_uc010qef.1_Frame_Shift_Ins_p.E305fs|ZEB1_uc009xlj.1_Frame_Shift_Ins_p.E449fs|ZEB1_uc010qeg.1_Frame_Shift_Ins_p.E382fs|ZEB1_uc009xlk.1_Frame_Shift_Ins_p.E305fs|ZEB1_uc001ivt.3_Frame_Shift_Ins_p.E305fs|ZEB1_uc001ivu.3_Frame_Shift_Ins_p.E524fs|ZEB1_uc001ivv.3_Frame_Shift_Ins_p.E503fs|ZEB1_uc010qeh.1_Frame_Shift_Ins_p.E456fs|ZEB1_uc009xlo.1_Frame_Shift_Ins_p.E506fs|ZEB1_uc009xlp.2_Frame_Shift_Ins_p.E507fs	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	523_524					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				AAAGCTTTGAAGGGGGGGTGAA	0.371	Ovarian(40;423 959 14296 36701 49589)		NA											11	256	---	---	---	---	NA	NA	NA	NA	NA
PARD3	56288	broad.mit.edu	37	10	34666941	34666942	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:34666941_34666942insC	uc010qej.1	-	10	1492_1493	c.1492_1493insG	c.(1492-1494)GCGfs	p.A498fs	PARD3_uc010qek.1_Frame_Shift_Ins_p.A498fs|PARD3_uc010qel.1_Frame_Shift_Ins_p.A498fs|PARD3_uc010qem.1_Frame_Shift_Ins_p.A498fs|PARD3_uc010qen.1_Frame_Shift_Ins_p.A498fs|PARD3_uc010qeo.1_Frame_Shift_Ins_p.A498fs|PARD3_uc010qep.1_Frame_Shift_Ins_p.A454fs|PARD3_uc010qeq.1_Frame_Shift_Ins_p.A454fs|PARD3_uc001ixo.1_Frame_Shift_Ins_p.A228fs|PARD3_uc001ixp.1_Frame_Shift_Ins_p.A363fs|PARD3_uc001ixq.1_Frame_Shift_Ins_p.A498fs|PARD3_uc001ixr.1_Frame_Shift_Ins_p.A498fs|PARD3_uc001ixt.1_Frame_Shift_Ins_p.A319fs|PARD3_uc001ixu.1_Frame_Shift_Ins_p.A454fs|PARD3_uc001ixs.1_Frame_Shift_Ins_p.A151fs	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	498	PDZ 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				CTGAATGGCCGCCCCCCGGGGG	0.48			NA											7	154	---	---	---	---	NA	NA	NA	NA	NA
AGAP7	653268	broad.mit.edu	37	10	51465345	51465346	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:51465345_51465346insG	uc001jio.2	-	7	1236_1237	c.1110_1111insC	c.(1108-1113)CCCTCTfs	p.P370fs	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron	NM_001077685	NP_001071153	Q5VUJ5	AGAP7_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	370_371	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						GCATGAGGAGAGGGGGGCGGGT	0.53			NA											15	74	---	---	---	---	NA	NA	NA	NA	NA
SEC24C	9632	broad.mit.edu	37	10	75525559	75525560	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:75525559_75525560insC	uc001juw.2	+	11	1547_1548	c.1368_1369insC	c.(1366-1371)GTTCCCfs	p.V456fs	SEC24C_uc010qkn.1_Intron|SEC24C_uc009xrj.1_Frame_Shift_Ins_p.V314fs|SEC24C_uc001jux.2_Frame_Shift_Ins_p.V456fs|SEC24C_uc010qko.1_Frame_Shift_Ins_p.V337fs|SEC24C_uc010qkp.1_Intron|SEC24C_uc010qkq.1_Intron	NM_004922	NP_004913	P53992	SC24C_HUMAN	SEC24-related protein C	456_457					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			skin(2)|central_nervous_system(1)	3	Prostate(51;0.0112)					TTCCCACAGTTCCCCCCCAGTA	0.51			NA											18	371	---	---	---	---	NA	NA	NA	NA	NA
MYST4	23522	broad.mit.edu	37	10	76790222	76790223	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:76790222_76790223insC	uc001jwn.1	+	18	6133_6134	c.5640_5641insC	c.(5638-5643)CCACCCfs	p.P1880fs	MYST4_uc001jwo.1_Frame_Shift_Ins_p.P1588fs|MYST4_uc001jwp.1_Frame_Shift_Ins_p.P1697fs	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1880_1881	Interaction with RUNX1 and RUNX2.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					CCATGACCCCACCCCCCAACCT	0.535			NA	T	CREBBP	AML								10	243	---	---	---	---	NA	NA	NA	NA	NA
HECTD2	143279	broad.mit.edu	37	10	93272060	93272061	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:93272060_93272061insC	uc001khl.2	+	21	2350_2351	c.2250_2251insC	c.(2248-2253)CTTCCCfs	p.L750fs	LOC100188947_uc010qnl.1_Intron|HECTD2_uc010qnm.1_Frame_Shift_Ins_p.L754fs|HECTD2_uc001khm.2_RNA|HECTD2_uc009xty.1_Frame_Shift_Ins_p.L339fs|HECTD2_uc001khn.1_Frame_Shift_Ins_p.L400fs	NM_182765	NP_877497	Q5U5R9	HECD2_HUMAN	HECT domain containing 2 isoform a	750_751	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			skin(1)	1						AACTTTGCCTTCCCCCCTACAA	0.356	NSCLC(12;376 469 1699 39910 41417)		NA											8	451	---	---	---	---	NA	NA	NA	NA	NA
TLL2	7093	broad.mit.edu	37	10	98164994	98164995	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:98164994_98164995insG	uc001kml.1	-	10	1487_1488	c.1261_1262insC	c.(1261-1263)CTTfs	p.L421fs	TLL2_uc009xvf.1_Frame_Shift_Ins_p.L399fs	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	421	CUB 1.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CTTACCCAAAAGGGGGGCTTTT	0.48			NA											7	494	---	---	---	---	NA	NA	NA	NA	NA
BTRC	8945	broad.mit.edu	37	10	103310572	103310573	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:103310572_103310573insC	uc001kta.2	+	14	1886_1887	c.1773_1774insC	c.(1771-1776)GAACCCfs	p.E591fs	BTRC_uc001ktb.2_Frame_Shift_Ins_p.E555fs|BTRC_uc001ktc.2_Frame_Shift_Ins_p.E565fs	NM_033637	NP_378663	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing protein	591_592					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		CCCAAGCTGAACCCCCCCGTTC	0.431			NA											9	352	---	---	---	---	NA	NA	NA	NA	NA
TRUB1	142940	broad.mit.edu	37	10	116730191	116730192	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr10:116730191_116730192insC	uc001lcd.2	+	5	649_650	c.588_589insC	c.(586-591)GTGCCCfs	p.V196fs	TRUB1_uc010qsl.1_Frame_Shift_Ins_p.V98fs	NM_139169	NP_631908	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase homolog 1	196_197					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding				0		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		TAATGCAAGTGCCCCCCCTGTA	0.317			NA											12	183	---	---	---	---	NA	NA	NA	NA	NA
OR51E1	143503	broad.mit.edu	37	11	4674216	4674217	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:4674216_4674217insG	uc001lzi.3	+	2	604_605	c.460_461insG	c.(460-462)CGGfs	p.R154fs		NM_152430	NP_689643	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|pancreas(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCTGTGGTGCGGGGGGCTGCA	0.559			NA											29	926	---	---	---	---	NA	NA	NA	NA	NA
OR52B6	340980	broad.mit.edu	37	11	5602545	5602546	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:5602545_5602546insC	uc010qzi.1	+	1	439_440	c.439_440insC	c.(439-441)TCCfs	p.S147fs	HBG2_uc001mak.1_Intron	NM_001005162	NP_001005162	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B,	147	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCCATCTGCTCCCCCCTGCGA	0.51			NA											9	842	---	---	---	---	NA	NA	NA	NA	NA
DCHS1	8642	broad.mit.edu	37	11	6662141	6662142	+	Frame_Shift_Ins	INS	-	-	G	rs143767864	byFrequency	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:6662141_6662142insG	uc001mem.1	-	2	1113_1114	c.703_704insC	c.(703-705)CGGfs	p.R235fs		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	235	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGGGCCCTCCGGGGGGGTGAA	0.589			NA											8	86	---	---	---	---	NA	NA	NA	NA	NA
DDB1	1642	broad.mit.edu	37	11	61093159	61093160	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:61093159_61093160insC	uc001nrc.3	-	6	911_912	c.685_686insG	c.(685-687)GCCfs	p.A229fs	DDB1_uc010rle.1_Intron|DDB1_uc010rlf.1_Frame_Shift_Ins_p.A229fs|DDB1_uc010rlg.1_RNA|DDB1_uc001nrd.2_Frame_Shift_Ins_p.A229fs|DDB1_uc009ynl.1_Frame_Shift_Ins_p.A116fs	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	229	Interaction with CDT1.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						AATGATGATGGCCCCCCCAAAG	0.49			NA						NER					7	82	---	---	---	---	NA	NA	NA	NA	NA
CPSF7	79869	broad.mit.edu	37	11	61183884	61183885	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:61183884_61183885insG	uc001nrq.2	-	6	791_792	c.657_658insC	c.(655-660)CCCAGTfs	p.P219fs	CPSF7_uc001nro.2_Frame_Shift_Ins_p.P210fs|CPSF7_uc001nrp.2_Frame_Shift_Ins_p.P262fs|CPSF7_uc001nrr.2_Frame_Shift_Ins_p.P210fs|CPSF7_uc001nrs.1_Frame_Shift_Ins_p.P120fs	NM_001136040	NP_001129512	Q8N684	CPSF7_HUMAN	pre-mRNA cleavage factor I, 59 kDa subunit	219_220	Pro-rich.				mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						GGCAGCACACTGGGGGGCTTAT	0.594			NA											10	532	---	---	---	---	NA	NA	NA	NA	NA
BSCL2	26580	broad.mit.edu	37	11	62458782	62458783	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:62458782_62458783insC	uc001nuo.1	-	7	1206_1207	c.782_783insG	c.(781-783)GGCfs	p.G261fs	LRRN4CL_uc001nun.2_5'Flank|BSCL2_uc009yoc.1_Intron|BSCL2_uc001nup.2_Frame_Shift_Ins_p.G261fs|BSCL2_uc001nuq.1_Frame_Shift_Ins_p.G261fs|BSCL2_uc001nur.3_Frame_Shift_Ins_p.G325fs|BSCL2_uc009yod.2_Frame_Shift_Ins_p.G325fs|BSCL2_uc001nut.3_Frame_Shift_Ins_p.G325fs|HNRNPUL2_uc001nuu.1_RNA	NM_032667	NP_116056	Q96G97	BSCL2_HUMAN	seipin isoform 2	261	Helical; (Potential).				cell death	integral to endoplasmic reticulum membrane					0						GGGGCCAGATGCCCCCCCACAC	0.559			NA											7	140	---	---	---	---	NA	NA	NA	NA	NA
NCAM1	4684	broad.mit.edu	37	11	113076860	113076861	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:113076860_113076861insG	uc009yyq.1	+	5	926_927	c.232_233insG	c.(232-234)CGGfs	p.R78fs	NCAM1_uc001pno.2_Frame_Shift_Ins_p.R78fs	NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	196	Ig-like C2-type 2.|Extracellular (Potential).				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		AATCCTGGCACGGGGGGAGATC	0.495			NA											11	752	---	---	---	---	NA	NA	NA	NA	NA
MLL	4297	broad.mit.edu	37	11	118344185	118344186	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:118344185_118344186insC	uc001pta.2	+	3	2334_2335	c.2311_2312insC	c.(2311-2313)ACCfs	p.T771fs	MLL_uc001ptb.2_Frame_Shift_Ins_p.T771fs|MLL_uc001psz.1_Frame_Shift_Ins_p.T804fs|MLL_uc001ptd.1_Intron	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	771					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CTCACCTCTCACCCCCCCGTCT	0.45			NA	T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								9	196	---	---	---	---	NA	NA	NA	NA	NA
JAM3	83700	broad.mit.edu	37	11	134018467	134018468	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr11:134018467_134018468insG	uc001qhb.1	+	7	897_898	c.873_874insG	c.(871-876)ATTGGGfs	p.I291fs	JAM3_uc009zcz.1_Frame_Shift_Ins_p.I240fs	NM_032801	NP_116190	Q9BX67	JAM3_HUMAN	junctional adhesion molecule 3 precursor	246_247	Helical; (Potential).				angiogenesis|blood coagulation|regulation of neutrophil chemotaxis	cell-cell contact zone|desmosome|extracellular space|integral to membrane	integrin binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.06e-21)|all_epithelial(12;3.37e-16)|all_lung(97;7.03e-06)|Lung NSC(97;1.67e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0506)|Esophageal squamous(93;0.0566)		Epithelial(10;1.55e-09)|BRCA - Breast invasive adenocarcinoma(10;1.35e-08)|all cancers(11;2.81e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00402)|Lung(977;0.245)		GCGGAATTATTGGGGGGGTTCT	0.485			NA											9	205	---	---	---	---	NA	NA	NA	NA	NA
C1S	716	broad.mit.edu	37	12	7177938	7177939	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:7177938_7177939insC	uc001qsj.2	+	15	2769_2770	c.2050_2051insC	c.(2050-2052)ACCfs	p.T684fs	C1S_uc001qsk.2_Frame_Shift_Ins_p.T684fs|C1S_uc001qsl.2_Frame_Shift_Ins_p.T684fs|C1S_uc009zfr.2_Frame_Shift_Ins_p.T517fs|C1S_uc009zfs.2_RNA	NM_201442	NP_958850	P09871	C1S_HUMAN	complement component 1, s subcomponent	684					complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			skin(1)	1					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	GGAAAATAGCACCCCCCGTGAG	0.49	GBM(156;750 1943 12971 24779 31015)		NA											11	655	---	---	---	---	NA	NA	NA	NA	NA
CLSTN3	9746	broad.mit.edu	37	12	7288059	7288060	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:7288059_7288060insC	uc001qsr.2	+	4	798_799	c.520_521insC	c.(520-522)TCCfs	p.S174fs	CLSTN3_uc001qss.2_Frame_Shift_Ins_p.S186fs	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	174	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						CGGTGACTGCTCCCCCCAGTAC	0.574			NA											10	1253	---	---	---	---	NA	NA	NA	NA	NA
HEBP1	50865	broad.mit.edu	37	12	13142224	13142225	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:13142224_13142225insC	uc001rbd.2	-	2	376_377	c.203_204insG	c.(202-204)GGCfs	p.G68fs	HEBP1_uc001rbf.2_Frame_Shift_Ins_p.G68fs	NM_015987	NP_057071	Q9NRV9	HEBP1_HUMAN	heme binding protein 1	68					circadian rhythm	extracellular region				breast(1)	1		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.153)		TGTCATTGGTGCCCCCCGCATA	0.554			NA											10	958	---	---	---	---	NA	NA	NA	NA	NA
GRIN2B	2904	broad.mit.edu	37	12	14019043	14019044	+	Frame_Shift_Ins	INS	-	-	G	rs77738206		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:14019043_14019044insG	uc001rbt.2	-	2	278_279	c.99_100insC	c.(97-102)CCCAGCfs	p.P33fs		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	33_34	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATGCCAATGCTGGGGGGGCTCT	0.589			NA											9	163	---	---	---	---	NA	NA	NA	NA	NA
H3F3C	440093	broad.mit.edu	37	12	31945092	31945093	+	Frame_Shift_Ins	INS	-	-	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:31945092_31945093insA	uc001rkr.2	-	1	83_84	c.8_9insT	c.(7-9)CGAfs	p.R3fs		NM_001013699	NP_001013721	Q6NXT2	H3C_HUMAN	histone H3-like	3					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TCTGCTTGGTTCGGGCCATTTT	0.609			NA								HNSCC(67;0.2)			19	40	---	---	---	---	NA	NA	NA	NA	NA
PDE1B	5153	broad.mit.edu	37	12	54971059	54971060	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:54971059_54971060insC	uc001sgd.1	+	15	1724_1725	c.1558_1559insC	c.(1558-1560)GCCfs	p.A520fs	PDE1B_uc010soz.1_Frame_Shift_Ins_p.A383fs|PDE1B_uc010spa.1_Frame_Shift_Ins_p.A479fs|PDE1B_uc001sgf.2_Frame_Shift_Ins_p.A383fs|PDE1B_uc001sge.2_Frame_Shift_Ins_p.A500fs|PDE1B_uc009znq.2_Frame_Shift_Ins_p.A316fs	NM_000924	NP_000915	Q01064	PDE1B_HUMAN	phosphodiesterase 1B isoform 1	520					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						TGAAGAAGAGGCCCCCCCATCC	0.559			NA											10	338	---	---	---	---	NA	NA	NA	NA	NA
DGKA	1606	broad.mit.edu	37	12	56347513	56347514	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:56347513_56347514insC	uc001sij.2	+	24	2433_2434	c.2169_2170insC	c.(2167-2172)CCACCCfs	p.P723fs	DGKA_uc001sik.2_Frame_Shift_Ins_p.P723fs|DGKA_uc001sil.2_Frame_Shift_Ins_p.P723fs|DGKA_uc001sim.2_Frame_Shift_Ins_p.P723fs|DGKA_uc001sin.2_Frame_Shift_Ins_p.P723fs|DGKA_uc009zof.2_Frame_Shift_Ins_p.P369fs|DGKA_uc001sio.2_Frame_Shift_Ins_p.P465fs	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	723_724					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	TCATGGGCCCACCCCCCCGCTC	0.579			NA											9	308	---	---	---	---	NA	NA	NA	NA	NA
DCTN2	10540	broad.mit.edu	37	12	57927805	57927806	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:57927805_57927806insG	uc001som.1	-	7	731_732	c.599_600insC	c.(598-600)CCAfs	p.P200fs	DCTN2_uc009zpu.1_Frame_Shift_Ins_p.P205fs|DCTN2_uc009zpv.1_Frame_Shift_Ins_p.P113fs|DCTN2_uc009zpw.1_Frame_Shift_Ins_p.P113fs|DCTN2_uc001soo.1_RNA|DCTN2_uc001son.1_Frame_Shift_Ins_p.P113fs|DCTN2_uc001sop.1_Frame_Shift_Ins_p.P113fs|DCTN2_uc001soq.1_RNA|DCTN2_uc009zpx.1_Frame_Shift_Ins_p.P200fs	NM_006400	NP_006391	Q13561	DCTN2_HUMAN	dynactin 2	200					cell proliferation|G2/M transition of mitotic cell cycle|mitosis	centrosome|cytosol|dynactin complex|dynein complex|kinetochore|membrane|microtubule|vesicle	motor activity|protein binding			ovary(1)	1						GGCTGCTATCTGGGGGGGTCCC	0.5			NA											7	99	---	---	---	---	NA	NA	NA	NA	NA
TMTC3	160418	broad.mit.edu	37	12	88553910	88553910	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:88553910delG	uc001tau.2	+	5	748	c.528delG	c.(526-528)TTGfs	p.L176fs	TMTC3_uc009zsm.2_RNA	NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	176	Helical; (Potential).					integral to membrane	binding			skin(1)	1						CAATTGCCTTGACAGTGTTTT	0.308			NA											155	321	---	---	---	---	NA	NA	NA	NA	NA
PLA2G1B	5319	broad.mit.edu	37	12	120763693	120763694	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:120763693_120763694insC	uc001tyd.2	-	2	200_201	c.164_165insG	c.(163-165)GGCfs	p.G55fs	PLA2G1B_uc009zwx.2_Frame_Shift_Ins_p.G55fs	NM_000928	NP_000919	P04054	PA21B_HUMAN	phospholipase A2 group IB precursor	55					actin filament organization|activation of MAPK activity|activation of phospholipase A2 activity|arachidonic acid secretion|cellular response to insulin stimulus|glucose transport|interleukin-8 production|leukotriene biosynthetic process|multicellular organismal lipid catabolic process|neutrophil chemotaxis|neutrophil mediated immunity|phosphatidylcholine metabolic process|positive regulation of calcium ion transport into cytosol|positive regulation of DNA replication|positive regulation of immune response|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein secretion|positive regulation of transcription from RNA polymerase II promoter	extracellular space	bile acid binding|calcium ion binding|calcium-dependent phospholipase A2 activity|cell surface binding|receptor binding			skin(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGGTGCCTGAGCCCCCCAAGCC	0.604	NSCLC(64;1781 1795 22266 42732)|Esophageal Squamous(30;459 829 25326 35148)		NA									OREG0022189	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	195	---	---	---	---	NA	NA	NA	NA	NA
MSI1	4440	broad.mit.edu	37	12	120800902	120800903	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:120800902_120800903insC	uc001tye.1	-	6	409_410	c.345_346insG	c.(343-348)GGGCTGfs	p.G115fs		NM_002442	NP_002433	O43347	MSI1H_HUMAN	musashi 1	115_116	RRM 2.				nervous system development	cytoplasm|nucleus	nucleotide binding			central_nervous_system(2)|breast(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTCACCGACAGCCCCCCCACAA	0.564			NA											7	151	---	---	---	---	NA	NA	NA	NA	NA
PGAM5	192111	broad.mit.edu	37	12	133294121	133294121	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr12:133294121delC	uc009zyv.2	+	3	494	c.467delC	c.(466-468)ACCfs	p.T156fs	PGAM5_uc010tbr.1_RNA|PGAM5_uc001uku.2_Frame_Shift_Del_p.T156fs	NM_138575	NP_612642	Q96HS1	PGAM5_HUMAN	phosphoglycerate mutase family member 5	156						integral to membrane|mitochondrial outer membrane	phosphoprotein phosphatase activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.89e-08)|Epithelial(86;1.14e-07)|all cancers(50;3.57e-06)		GCCATAGAGACCACCGATATC	0.632			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
ATP12A	479	broad.mit.edu	37	13	25262563	25262564	+	Frame_Shift_Ins	INS	-	-	G	rs35191129		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr13:25262563_25262564insG	uc001upp.2	+	4	522_523	c.335_336insG	c.(334-336)GTGfs	p.V112fs	ATP12A_uc010aaa.2_Frame_Shift_Ins_p.V112fs	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	112	Helical; (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	AAGCAGATGGTGGGGGGGTTCT	0.584	Pancreas(156;1582 1935 18898 22665 26498)		NA											21	697	---	---	---	---	NA	NA	NA	NA	NA
KBTBD6	89890	broad.mit.edu	37	13	41705321	41705322	+	Frame_Shift_Ins	INS	-	-	C	rs147771080		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr13:41705321_41705322insC	uc001uxu.1	-	1	1615_1616	c.1326_1327insG	c.(1324-1329)GGGCGAfs	p.G442fs	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Frame_Shift_Ins_p.G376fs|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	442_443	Kelch 2.						protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		ATAGGGTCTCGCCCCCCCAAAA	0.47			NA											8	235	---	---	---	---	NA	NA	NA	NA	NA
TEP1	7011	broad.mit.edu	37	14	20852646	20852647	+	Frame_Shift_Ins	INS	-	-	C	rs144584331		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:20852646_20852647insC	uc001vxe.2	-	23	3282_3283	c.3242_3243insG	c.(3241-3243)GGTfs	p.G1081fs	TEP1_uc010ahk.2_Frame_Shift_Ins_p.G431fs|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Frame_Shift_Ins_p.G973fs|TEP1_uc010tlh.1_5'Flank	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1081					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CAGCTGCCACACCCCCCCACTC	0.584			NA											14	245	---	---	---	---	NA	NA	NA	NA	NA
FLJ10357	55701	broad.mit.edu	37	14	21546603	21546604	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:21546603_21546604insG	uc001vzp.2	+	10	2231_2232	c.2202_2203insG	c.(2200-2205)GATGGGfs	p.D734fs	FLJ10357_uc001vzo.1_Intron|FLJ10357_uc010aij.2_RNA|FLJ10357_uc010tln.1_Frame_Shift_Ins_p.D20fs	NM_018071	NP_060541	Q8TER5	ARH40_HUMAN	hypothetical protein LOC55701	734_735					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;5.79e-11)|Epithelial(56;8.35e-09)|all cancers(55;4.23e-08)	GBM - Glioblastoma multiforme(265;0.0197)		TGCAGAGGGATGGGGGGGCCAT	0.629			NA											13	259	---	---	---	---	NA	NA	NA	NA	NA
CHD8	57680	broad.mit.edu	37	14	21896303	21896304	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:21896303_21896304insC	uc001was.1	-	4	582_583	c.488_489insG	c.(487-489)GGAfs	p.G163fs	CHD8_uc001war.1_Frame_Shift_Ins_p.G59fs	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	442					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TTCCTGTCTTTCCCCCCGAATG	0.54			NA											8	532	---	---	---	---	NA	NA	NA	NA	NA
SALL2	6297	broad.mit.edu	37	14	21992275	21992276	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:21992275_21992276insG	uc001wbe.2	-	2	1868_1869	c.1586_1587insC	c.(1585-1587)CCAfs	p.P529fs	SALL2_uc010tly.1_Frame_Shift_Ins_p.P527fs|SALL2_uc010tlz.1_Frame_Shift_Ins_p.P392fs|SALL2_uc001wbf.3_Intron|SALL2_uc010tma.1_Frame_Shift_Ins_p.P394fs|SALL2_uc001wbg.1_Intron	NM_005407	NP_005398	Q9Y467	SALL2_HUMAN	sal-like 2	529							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|large_intestine(1)	3	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		CCTCACTCCCTGGGGGGGTGTT	0.53			NA											14	258	---	---	---	---	NA	NA	NA	NA	NA
OR10G2	26534	broad.mit.edu	37	14	22102924	22102925	+	Frame_Shift_Ins	INS	-	-	G	rs150140072		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:22102924_22102925insG	uc010tmc.1	-	1	74_75	c.74_75insC	c.(73-75)CCAfs	p.P25fs		NM_001005466	NP_001005466	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G,	25	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		TTCTTAGATTTGGGGGGTGAGA	0.48			NA											9	414	---	---	---	---	NA	NA	NA	NA	NA
AKAP6	9472	broad.mit.edu	37	14	32902724	32902725	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:32902724_32902725insC	uc001wrq.2	+	2	195_196	c.25_26insC	c.(25-27)TCCfs	p.S9fs	AKAP6_uc010aml.2_Frame_Shift_Ins_p.S6fs	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	9					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CGTGACACTTTCCCCCCTGAGG	0.505	Melanoma(49;821 1200 7288 13647 42351)		NA											8	971	---	---	---	---	NA	NA	NA	NA	NA
KCNH5	27133	broad.mit.edu	37	14	63174302	63174303	+	Frame_Shift_Ins	INS	-	-	G	rs35940222		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:63174302_63174303insG	uc001xfx.2	-	11	2941_2942	c.2890_2891insC	c.(2890-2892)CAGfs	p.Q964fs	KCNH5_uc001xfy.2_3'UTR	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	964	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		ACATGGTATCTGGGGGGGTACT	0.381			NA											10	210	---	---	---	---	NA	NA	NA	NA	NA
YLPM1	56252	broad.mit.edu	37	14	75248518	75248519	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr14:75248518_75248519insC	uc001xqj.3	+	4	1896_1897	c.1772_1773insC	c.(1771-1773)CTCfs	p.L591fs	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CCACCAGTTCTCCCCCCACCTT	0.599			NA											7	341	---	---	---	---	NA	NA	NA	NA	NA
OR4M2	390538	broad.mit.edu	37	15	22369023	22369024	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:22369023_22369024insG	uc010tzu.1	+	1	448_449	c.448_449insG	c.(448-450)AGGfs	p.R150fs	LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TCTCTCCTGGAGGGGGGGCTTC	0.5			NA											15	406	---	---	---	---	NA	NA	NA	NA	NA
MAPKBP1	23005	broad.mit.edu	37	15	42092080	42092080	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:42092080delC	uc001zok.3	+	3	460	c.174delC	c.(172-174)GACfs	p.D58fs	MAPKBP1_uc001zoj.3_Frame_Shift_Del_p.D58fs|MAPKBP1_uc010bcj.2_5'UTR|MAPKBP1_uc010bci.2_Frame_Shift_Del_p.D58fs|MAPKBP1_uc010udb.1_Intron|MAPKBP1_uc010bck.2_5'UTR	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	58										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		TTGCCTGTGACCCCCGATCAG	0.502			NA											80	227	---	---	---	---	NA	NA	NA	NA	NA
PRTG	283659	broad.mit.edu	37	15	55912218	55912219	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:55912218_55912219insG	uc002adg.2	-	20	3492_3493	c.3444_3445insC	c.(3442-3447)CCCAACfs	p.P1148fs		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	1148_1149					multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		AATCAGAGGTTGGGGGGTGTGG	0.49			NA											7	246	---	---	---	---	NA	NA	NA	NA	NA
UACA	55075	broad.mit.edu	37	15	70991941	70991942	+	Frame_Shift_Ins	INS	-	-	C	rs139520381		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr15:70991941_70991942insC	uc002asr.2	-	2	240_241	c.136_137insG	c.(136-138)GATfs	p.D46fs	UACA_uc010uke.1_Frame_Shift_Ins_p.D46fs|UACA_uc002asq.2_Frame_Shift_Ins_p.D33fs|UACA_uc010bin.1_Frame_Shift_Ins_p.D32fs	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	46	ANK 1.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						TTTTTCTACATCCCCCCTTTCT	0.371			NA											7	903	---	---	---	---	NA	NA	NA	NA	NA
GRIN2A	2903	broad.mit.edu	37	16	10273964	10273964	+	Frame_Shift_Del	DEL	T	T	-			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:10273964delT	uc002czo.3	-	2	853	c.305delA	c.(304-306)GACfs	p.D102fs	GRIN2A_uc010uym.1_Frame_Shift_Del_p.D102fs|GRIN2A_uc002czr.3_Frame_Shift_Del_p.D102fs|GRIN2A_uc010buk.2_Frame_Shift_Del_p.D102fs	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	102	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GTCCGTGTCGTCCCCAAACAC	0.602			NA											31	142	---	---	---	---	NA	NA	NA	NA	NA
NOMO1	23420	broad.mit.edu	37	16	14980694	14980695	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:14980694_14980695insC	uc002dcv.2	+	28	3365_3366	c.3299_3300insC	c.(3298-3300)TTCfs	p.F1100fs		NM_014287	NP_055102	Q15155	NOMO1_HUMAN	nodal modulator 1 precursor	1100	Extracellular (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			ovary(1)	1						TTCTTCCATTTCCCCCCACTGC	0.475			NA											9	453	---	---	---	---	NA	NA	NA	NA	NA
POLR3E	55718	broad.mit.edu	37	16	22339833	22339834	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:22339833_22339834insC	uc002dkk.2	+	19	2025_2026	c.1869_1870insC	c.(1867-1872)TTTCCCfs	p.F623fs	POLR3E_uc002dkj.1_3'UTR|POLR3E_uc002dkm.2_Frame_Shift_Ins_p.F587fs|POLR3E_uc010vbr.1_Frame_Shift_Ins_p.F623fs|POLR3E_uc002dkl.2_Frame_Shift_Ins_p.F623fs|POLR3E_uc010vbs.1_Frame_Shift_Ins_p.F587fs|POLR3E_uc010vbt.1_Frame_Shift_Ins_p.F567fs	NM_018119	NP_060589	Q9NVU0	RPC5_HUMAN	RNA polymerase III polypeptide E	623_624					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.012)		TTGGTCAGTTTCCCCCCCAGAC	0.559			NA											7	122	---	---	---	---	NA	NA	NA	NA	NA
MT4	84560	broad.mit.edu	37	16	56602768	56602769	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr16:56602768_56602769insC	uc002eje.1	+	3	193_194	c.113_114insC	c.(112-114)TGCfs	p.C38fs		NM_032935	NP_116324	P47944	MT4_HUMAN	metallothionein 4	38		Divalent metal cation; cluster A (By similarity).				cytoplasm	copper ion binding|zinc ion binding			ovary(1)	1						TGTCCCTGCTGCCCCCCGGGCT	0.599			NA											7	510	---	---	---	---	NA	NA	NA	NA	NA
PLSCR3	57048	broad.mit.edu	37	17	7294058	7294059	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:7294058_7294059insC	uc002ggm.1	-	7	934_935	c.725_726insG	c.(724-726)GGCfs	p.G242fs	PLSCR3_uc002ggl.2_Frame_Shift_Ins_p.G218fs|PLSCR3_uc002ggq.1_Frame_Shift_Ins_p.G73fs|PLSCR3_uc002ggn.1_Frame_Shift_Ins_p.G242fs|PLSCR3_uc002ggo.1_Frame_Shift_Ins_p.G242fs|PLSCR3_uc002ggp.1_Frame_Shift_Ins_p.G73fs|PLSCR3_uc002ggr.1_Frame_Shift_Ins_p.G242fs|PLSCR3_uc010cmg.1_Frame_Shift_Ins_p.G242fs	NM_020360	NP_065093	Q9NRY6	PLS3_HUMAN	phospholipid scramblase 3	242	Cytoplasmic (By similarity).				phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|calcium-dependent protein binding|phospholipid scramblase activity|SH3 domain binding				0		Prostate(122;0.173)				CTCGGACCAGGCCCCCCCACTG	0.614			NA											7	137	---	---	---	---	NA	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7578463	7578502	+	Frame_Shift_Del	DEL	CGGGTGCCGGGCGGGGGTGTGGAATCAACCCACAGCTGCA	CGGGTGCCGGGCGGGGGTGTGGAATCAACCCACAGCTGCA	-	rs137852793		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	CGGGTGCCGGGCGGGGGTGTGGAATCAACCCACAGCTGCA	CGGGTGCCGGGCGGGGGTGTGGAATCAACCCACAGCTGCA	-	-	CGGGTGCCGGGCGGGGGTGTGGAATCAACCCACAGCTGCA	CGGGTGCCGGGCGGGGGTGTGGAATCAACCCACAGCTGCA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:7578463_7578502delCGGGTGCCGGGCGGGGGTGTGGAATCAACCCACAGCTGCA	uc002gim.2	-	5	622_661	c.428_467delTGCAGCTGTGGGTTGATTCCACACCCCCGCCCGGCACCCG	c.(427-468)GTGCAGCTGTGGGTTGATTCCACACCCCCGCCCGGCACCCGCfs	p.V143fs	TP53_uc002gig.1_Frame_Shift_Del_p.V143fs|TP53_uc002gih.2_Frame_Shift_Del_p.V143fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.V11fs|TP53_uc010cng.1_Frame_Shift_Del_p.V11fs|TP53_uc002gii.1_Frame_Shift_Del_p.V11fs|TP53_uc010cnh.1_Frame_Shift_Del_p.V143fs|TP53_uc010cni.1_Frame_Shift_Del_p.V143fs|TP53_uc002gij.2_Frame_Shift_Del_p.V143fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.V50fs|TP53_uc002gio.2_Frame_Shift_Del_p.V11fs|TP53_uc010vug.1_Frame_Shift_Del_p.V104fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	143_156	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P151S(61)|p.W146*(61)|p.P152L(57)|p.G154V(36)|p.Q144*(29)|p.P151H(25)|p.R156P(24)|p.P152S(21)|p.T155N(19)|p.L145Q(17)|p.L145P(17)|p.P152fs*18(17)|p.V143M(16)|p.V143A(15)|p.T155P(14)|p.P151T(13)|p.G154G(12)|p.P151P(12)|p.R156H(10)|p.T155I(10)|p.P151A(10)|p.P153fs*28(10)|p.G154S(9)|p.R156fs*14(8)|p.L145L(8)|p.Q144L(8)|p.P153S(8)|p.L145R(7)|p.P151fs*30(7)|p.T155A(7)|p.0?(7)|p.P152T(7)|p.P153P(7)|p.G154D(6)|p.V147G(6)|p.P151L(6)|p.P151R(6)|p.S149S(6)|p.S149F(6)|p.V147I(6)|p.P153L(6)|p.P152fs*29(5)|p.V147fs*23(5)|p.W146R(5)|p.T155T(5)|p.S149fs*32(5)|p.P152P(5)|p.V147D(4)|p.V143E(4)|p.P152fs*14(4)|p.V143L(4)|p.P152Q(4)|p.T150I(4)|p.Q144H(4)|p.D148E(4)|p.D148N(4)|p.Q144R(4)|p.Q144P(4)|p.S149P(4)|p.P152fs*28(3)|p.R156S(3)|p.R156fs*25(3)|p.R156G(3)|p.R156L(3)|p.Q144fs*26(3)|p.G154I(3)|p.T150fs*16(3)|p.P152R(3)|p.S149fs*21(3)|p.P153T(3)|p.G154fs*27(3)|p.V147V(3)|p.V143fs*27(2)|p.D148fs*33(2)|p.T155fs*23(2)|p.L145V(2)|p.R156C(2)|p.G154fs*16(2)|p.G154fs*14(2)|p.R156_I162delRVRAMAI(2)|p.V143V(2)|p.T155S(2)|p.Q144del(2)|p.Q144K(2)|p.P152A(2)|p.V147A(2)|p.D148V(2)|p.Q144Q(2)|p.P153fs*26(2)|p.S149T(2)|p.P153fs*22(2)|p.D148fs*23(2)|p.D148fs*22(2)|p.W146C(2)|p.L137_W146del10(1)|p.V143fs*29(1)|p.T150R(1)|p.D148fs*34(1)|p.D148fs*32(1)|p.L145del(1)|p.G154_R156delGTR(1)|p.T155fs*26(1)|p.T155fs*25(1)|p.W146fs*25(1)|p.W146fs*22(1)|p.W146fs*23(1)|p.T155_A161delTRVRAMA(1)|p.P58A(1)|p.Q144_G154del11(1)|p.W146_V147insXXXXXXX(1)|p.T150fs*31(1)|p.Q144fs*32(1)|p.D148_T155delDSTPPPGT(1)|p.R156_A161delRVRAMA(1)|p.R156del(1)|p.R156fs*12(1)|p.R156fs*18(1)|p.T150fs*23(1)|p.T150_P153delTPPP(1)|p.G154A(1)|p.G154C(1)|p.P152del(1)|p.V143G(1)|p.S149fs*72(1)|p.Q144fs*16(1)|p.P153_G154insX(1)|p.K139fs*4(1)|p.V11A(1)|p.C141fs*5(1)|p.P152_P153del(1)|p.R156_R158delRVR(1)|p.V50A(1)|p.P151del(1)|p.W146_S149>C(1)|p.D148del(1)|p.T150K(1)|p.S149fs*17(1)|p.V143_S149del(1)|p.P152_P153insXXX(1)|p.T155_R156delTR(1)|p.T150_P151delTP(1)|p.Q144fs*4(1)|p.P142_Q144delPVQ(1)|p.P153fs*16(1)|p.D148Y(1)|p.P151_V173del23(1)|p.D148D(1)|p.D148H(1)|p.A138_V143delAKTCPV(1)|p.R156_A161del(1)|p.P153fs*20(1)|p.W146S(1)|p.W146fs*1(1)|p.S149fs*31(1)|p.W146G(1)|p.V147E(1)|p.G154fs*22(1)|p.V147F(1)|p.L145M(1)|p.P153F(1)|p.P153A(1)|p.D148*(1)|p.P19A(1)|p.P153H(1)|p.T155fs*15(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCGCGGACGCGGGTGCCGGGCGGGGGTGTGGAATCAACCCACAGCTGCACAGGGCAGGT	0.592	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			7	156	---	---	---	---	NA	NA	NA	NA	NA
SSH2	85464	broad.mit.edu	37	17	27959374	27959375	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:27959374_27959375insG	uc002heo.1	-	15	2756_2757	c.2756_2757insC	c.(2755-2757)CCAfs	p.P919fs	SSH2_uc010wbh.1_Frame_Shift_Ins_p.P946fs	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	919					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						ATGAATGTTCTGGGGGGGCTTC	0.48			NA											26	516	---	---	---	---	NA	NA	NA	NA	NA
ACACA	31	broad.mit.edu	37	17	35600370	35600371	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:35600370_35600371insG	uc002hnm.2	-	22	2927_2928	c.2736_2737insC	c.(2734-2739)CCCAATfs	p.P912fs	ACACA_uc002hnk.2_Frame_Shift_Ins_p.P834fs|ACACA_uc002hnl.2_Frame_Shift_Ins_p.P854fs|ACACA_uc002hnn.2_Frame_Shift_Ins_p.P912fs|ACACA_uc002hno.2_Frame_Shift_Ins_p.P949fs|ACACA_uc010cuz.2_Frame_Shift_Ins_p.P912fs	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	912_913					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TTCTCCACATTGGGGGGAATGC	0.47	Colon(23;82 258 739 2117 10493 24037 27661 34815 35438 36249)		NA											7	702	---	---	---	---	NA	NA	NA	NA	NA
CA10	56934	broad.mit.edu	37	17	50008356	50008357	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:50008356_50008357insC	uc002itw.3	-	3	1258_1259	c.272_273insG	c.(271-273)GGCfs	p.G91fs	CA10_uc002itv.3_Frame_Shift_Ins_p.G97fs|CA10_uc002itx.3_Frame_Shift_Ins_p.G91fs|CA10_uc002ity.3_Frame_Shift_Ins_p.G91fs|CA10_uc002itz.2_Frame_Shift_Ins_p.G91fs	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	91					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TTACCTTCCTGCCCCCCGTGTT	0.49			NA											11	694	---	---	---	---	NA	NA	NA	NA	NA
MARCH10	162333	broad.mit.edu	37	17	60814265	60814266	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:60814265_60814266insC	uc010ddr.2	-	6	1201_1202	c.963_964insG	c.(961-966)GGGACAfs	p.G321fs	MARCH10_uc002jag.3_Frame_Shift_Ins_p.G321fs|MARCH10_uc010dds.2_Frame_Shift_Ins_p.G359fs|MARCH10_uc002jah.2_Frame_Shift_Ins_p.G320fs|uc002jaj.1_RNA|uc002jak.2_RNA	NM_001100875	NP_001094345	Q8NA82	MARHA_HUMAN	ring finger protein 190	321_322							ligase activity|zinc ion binding				0						GGGGTCGATGTCCCCCCAAATC	0.46			NA											8	620	---	---	---	---	NA	NA	NA	NA	NA
FAM104A	84923	broad.mit.edu	37	17	71223356	71223357	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr17:71223356_71223357insG	uc002jji.3	-	2	356_357	c.268_269insC	c.(268-270)CAGfs	p.Q90fs	FAM104A_uc002jjj.3_Frame_Shift_Ins_p.Q90fs	NM_032837	NP_116226	Q969W3	F104A_HUMAN	hypothetical protein LOC84923 isoform 2	90											0			LUSC - Lung squamous cell carcinoma(166;0.197)			TCTTTTGGTCTGGGGGGGAAGA	0.416			NA											7	168	---	---	---	---	NA	NA	NA	NA	NA
ALPK2	115701	broad.mit.edu	37	18	56246441	56246442	+	Frame_Shift_Ins	INS	-	-	C	rs12606191	byFrequency	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr18:56246441_56246442insC	uc002lhj.3	-	4	1780_1781	c.1566_1567insG	c.(1564-1569)GGAAAGfs	p.G522fs		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	522_523							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						CATAAGTCCTTTCCCCCCACTC	0.52			NA									OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	487	---	---	---	---	NA	NA	NA	NA	NA
SERPINB7	8710	broad.mit.edu	37	18	61449757	61449758	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr18:61449757_61449758delCT	uc002ljl.2	+	2	247_248	c.151_152delCT	c.(151-153)CTCfs	p.L51fs	SERPINB7_uc002ljm.2_Frame_Shift_Del_p.L51fs|SERPINB7_uc010xet.1_Frame_Shift_Del_p.L51fs|SERPINB7_uc010dqg.2_Frame_Shift_Del_p.L51fs	NM_001040147	NP_001035237	O75635	SPB7_HUMAN	serine (or cysteine) proteinase inhibitor, clade	51					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			lung(2)|central_nervous_system(1)	3		Esophageal squamous(42;0.129)				AGATGACTCCCTCTCTCAGATT	0.47			NA											82	345	---	---	---	---	NA	NA	NA	NA	NA
CNDP2	55748	broad.mit.edu	37	18	72168667	72168668	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr18:72168667_72168668insG	uc002llm.1	+	3	326_327	c.164_165insG	c.(163-165)TTGfs	p.L55fs	CNDP2_uc002lln.1_Frame_Shift_Ins_p.L55fs|CNDP2_uc002llo.2_Frame_Shift_Ins_p.L55fs	NM_018235	NP_060705	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2	55						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			ovary(2)|skin(1)	3		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		GTTAAGCAGTTGGGGGGCTCTG	0.52			NA											7	326	---	---	---	---	NA	NA	NA	NA	NA
C3	718	broad.mit.edu	37	19	6697480	6697481	+	Frame_Shift_Ins	INS	-	-	G	rs137956083		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:6697480_6697481insG	uc002mfm.2	-	21	2732_2733	c.2670_2671insC	c.(2668-2673)CCCAAGfs	p.P890fs		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	890_891					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		AACGAGGACTTGGGGGGGATGG	0.574			NA											9	296	---	---	---	---	NA	NA	NA	NA	NA
ZNF878	729747	broad.mit.edu	37	19	12155624	12155625	+	Frame_Shift_Ins	INS	-	-	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:12155624_12155625insT	uc002mta.1	-	5	732_733	c.732_733insA	c.(730-735)AAACCCfs	p.K244fs		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	197_198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						CATTCATAGGGTTTTTTTGCAG	0.396			NA											8	362	---	---	---	---	NA	NA	NA	NA	NA
C19orf40	91442	broad.mit.edu	37	19	33464113	33464114	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:33464113_33464114insC	uc002nud.3	+	2	129_130	c.11_12insC	c.(10-12)AACfs	p.N4fs	CCDC123_uc002nty.2_5'Flank|CCDC123_uc010edg.2_5'Flank|CCDC123_uc002ntz.1_5'Flank|CCDC123_uc002nua.2_5'Flank|CCDC123_uc002nuc.1_5'Flank	NM_152266	NP_689479	Q9BTP7	FAP24_HUMAN	Fanconi anemia-associated protein, 24 kDa	4					DNA repair	Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding				0	Esophageal squamous(110;0.137)					ATGGAAAAGAACCCCCCTGATG	0.609			NA						Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks					8	1451	---	---	---	---	NA	NA	NA	NA	NA
AXL	558	broad.mit.edu	37	19	41743932	41743933	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:41743932_41743933insC	uc010ehj.2	+	7	1057_1058	c.867_868insC	c.(865-870)GTGCCCfs	p.V289fs	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehi.1_Frame_Shift_Ins_p.V289fs|AXL_uc010ehk.2_Frame_Shift_Ins_p.V289fs	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	289_290	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.V289M(1)		lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						AAGCATCCGTGCCCCCCCATCA	0.649			NA											8	219	---	---	---	---	NA	NA	NA	NA	NA
MARK4	57787	broad.mit.edu	37	19	45805663	45805664	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:45805663_45805664insC	uc002pbb.1	+	17	1959_1960	c.1954_1955insC	c.(1954-1956)GCCfs	p.A652fs	MARK4_uc002pba.1_Frame_Shift_Ins_p.P678fs			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	652					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		AACGGAAACCGCCCCCCGGCTG	0.639			NA											7	182	---	---	---	---	NA	NA	NA	NA	NA
CARD8	22900	broad.mit.edu	37	19	48737669	48737670	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:48737669_48737670insC	uc002pie.3	-	3	379_380	c.66_67insG	c.(64-69)GGGACAfs	p.G22fs	CARD8_uc002pii.3_Frame_Shift_Ins_p.D114fs|CARD8_uc010xzi.1_Frame_Shift_Ins_p.G22fs|CARD8_uc010els.2_5'Flank|CARD8_uc010xzj.1_Frame_Shift_Ins_p.D114fs|CARD8_uc010xzk.1_Frame_Shift_Ins_p.G46fs|CARD8_uc002pif.3_Frame_Shift_Ins_p.G22fs|CARD8_uc002pig.3_5'UTR|CARD8_uc002pih.3_Frame_Shift_Ins_p.D64fs|CARD8_uc010xzl.1_Frame_Shift_Ins_p.D64fs|CARD8_uc010xzm.1_Frame_Shift_Ins_p.D114fs	NM_014959	NP_055774	Q9Y2G2	CARD8_HUMAN	caspase recruitment domain family, member 8	22_23					negative regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion	cytoplasm|nucleus	caspase activator activity|NACHT domain binding|protein homodimerization activity				0		all_lung(116;0.000112)|Lung NSC(112;0.000192)|all_epithelial(76;0.000349)|all_neural(266;0.0228)|Ovarian(192;0.113)|Prostate(7;0.184)		OV - Ovarian serous cystadenocarcinoma(262;0.000112)|all cancers(93;0.000293)|Epithelial(262;0.0129)|GBM - Glioblastoma multiforme(486;0.0336)		CCTGGGAATGTCCCCCCCAGAT	0.436			NA											8	269	---	---	---	---	NA	NA	NA	NA	NA
HRC	3270	broad.mit.edu	37	19	49657097	49657098	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:49657097_49657098insG	uc002pmv.2	-	1	1584_1585	c.1397_1398insC	c.(1396-1398)CCAfs	p.P466fs		NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	466					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		CTGTGTGTCCTGGGGGGTGATG	0.55	Melanoma(37;75 1097 24567 25669 30645)		NA											7	303	---	---	---	---	NA	NA	NA	NA	NA
ZNF160	90338	broad.mit.edu	37	19	53571731	53571732	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	AG	AG	-	-	AG	AG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr19:53571731_53571732delAG	uc010eqk.2	-	7	2471_2472	c.2055_2056delCT	c.(2053-2058)GTCTTCfs	p.V685fs	ZNF160_uc002qaq.3_Frame_Shift_Del_p.V685fs|ZNF160_uc002qar.3_Frame_Shift_Del_p.V685fs	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	685_686	C2H2-type 16.				hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)		TTCTGAGTGAAGACCTTGCCAC	0.441			NA											32	375	---	---	---	---	NA	NA	NA	NA	NA
NFU1	27247	broad.mit.edu	37	2	69659083	69659084	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:69659083_69659084delCT	uc002sfk.2	-	2	315_316	c.116_117delAG	c.(115-117)CAGfs	p.Q39fs	NFU1_uc002sfj.2_Frame_Shift_Del_p.Q15fs|NFU1_uc002sfl.2_5'UTR|NFU1_uc002sfm.2_5'UTR|NFU1_uc010fdi.2_RNA|NFU1_uc002sfn.1_Frame_Shift_Del_p.Q39fs	NM_001002755	NP_001002755	Q9UMS0	NFU1_HUMAN	HIRA interacting protein 5 isoform 2	39					iron-sulfur cluster assembly	cytosol|mitochondrion|nucleus	4 iron, 4 sulfur cluster binding|iron ion binding|protein binding				0						TTTGTACAAACTGATGCAGAGG	0.371			NA											23	77	---	---	---	---	NA	NA	NA	NA	NA
ALMS1	7840	broad.mit.edu	37	2	73678333	73678333	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:73678333delC	uc002sje.1	+	10	4793	c.4682delC	c.(4681-4683)ACAfs	p.T1561fs	ALMS1_uc002sjf.1_Frame_Shift_Del_p.T1517fs|ALMS1_uc002sjg.2_Frame_Shift_Del_p.T947fs|ALMS1_uc002sjh.1_Frame_Shift_Del_p.T947fs	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1559	22.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						GCTGACCAGACAACTGGCATA	0.468			NA											47	233	---	---	---	---	NA	NA	NA	NA	NA
IL1R2	7850	broad.mit.edu	37	2	102638681	102638682	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:102638681_102638682insC	uc002tbm.2	+	6	950_951	c.721_722insC	c.(721-723)TCCfs	p.S241fs	IL1R2_uc002tbn.2_Frame_Shift_Ins_p.S241fs|IL1R2_uc002tbo.1_Frame_Shift_Ins_p.S241fs	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	241	Extracellular (Potential).|Ig-like C2-type 3.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)	TGTGATCATTTCCCCCCTCAAG	0.49	Pancreas(106;189 1628 2302 5133 12295)		NA											7	442	---	---	---	---	NA	NA	NA	NA	NA
SLC9A2	6549	broad.mit.edu	37	2	103324745	103324746	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:103324745_103324746insC	uc002tca.2	+	12	2378_2379	c.2236_2237insC	c.(2236-2238)ACCfs	p.T746fs		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	746	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						TATGCCCAGCACCCCCCCAACA	0.53			NA											14	288	---	---	---	---	NA	NA	NA	NA	NA
R3HDM1	23518	broad.mit.edu	37	2	136389448	136389449	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:136389448_136389449insC	uc002tuo.2	+	9	945_946	c.575_576insC	c.(574-576)TTCfs	p.F192fs	R3HDM1_uc010fni.2_Frame_Shift_Ins_p.F190fs|R3HDM1_uc002tup.2_Frame_Shift_Ins_p.F136fs|R3HDM1_uc010zbh.1_Frame_Shift_Ins_p.F24fs	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	192	R3H.						nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		CGTAAAAAATTCCCCCCAATGA	0.396			NA											8	326	---	---	---	---	NA	NA	NA	NA	NA
XIRP2	129446	broad.mit.edu	37	2	168099957	168099958	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:168099957_168099958insG	uc002udx.2	+	8	2073_2074	c.2055_2056insG	c.(2053-2058)ACTGGGfs	p.T685fs	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Frame_Shift_Ins_p.T510fs|XIRP2_uc010fpq.2_Frame_Shift_Ins_p.T463fs|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	510_511					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGGACATAACTGGGGGGGATGT	0.421			NA											11	321	---	---	---	---	NA	NA	NA	NA	NA
MYO3B	140469	broad.mit.edu	37	2	171240258	171240259	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:171240258_171240259insC	uc002ufy.2	+	12	1367_1368	c.1224_1225insC	c.(1222-1227)AATCCCfs	p.N408fs	MYO3B_uc002ufv.2_Frame_Shift_Ins_p.N395fs|MYO3B_uc010fqb.1_Frame_Shift_Ins_p.N395fs|MYO3B_uc002ufz.2_Frame_Shift_Ins_p.N408fs|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	408_409	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						GCGCCTCCAATCCCCCCCACAT	0.465			NA											7	387	---	---	---	---	NA	NA	NA	NA	NA
NEUROD1	4760	broad.mit.edu	37	2	182542971	182542972	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr2:182542971_182542972insG	uc002uof.2	-	2	852_853	c.616_617insC	c.(616-618)CACfs	p.H206fs	CERKL_uc002uod.1_Intron	NM_002500	NP_002491	Q13562	NDF1_HUMAN	neurogenic differentiation 1	206					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CGTCGGCAGGTGGGGGGGCATG	0.619			NA											10	173	---	---	---	---	NA	NA	NA	NA	NA
CST1	1469	broad.mit.edu	37	20	23729753	23729754	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr20:23729753_23729754insC	uc002wtp.2	-	2	312_313	c.241_242insG	c.(241-243)GTGfs	p.V81fs		NM_001898	NP_001889	P01037	CYTN_HUMAN	cystatin SN precursor	81						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Lung NSC(19;0.0676)|all_lung(19;0.148)					GAAGTAATTCACCCCCCCAACG	0.554			NA											13	378	---	---	---	---	NA	NA	NA	NA	NA
RALGAPB	57148	broad.mit.edu	37	20	37146232	37146233	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr20:37146232_37146233insC	uc002xiw.2	+	8	1392_1393	c.1135_1136insC	c.(1135-1137)ACCfs	p.T379fs	RALGAPB_uc010zvz.1_Frame_Shift_Ins_p.T379fs|RALGAPB_uc002xix.2_Frame_Shift_Ins_p.T379fs|RALGAPB_uc002xiy.1_Frame_Shift_Ins_p.T379fs|RALGAPB_uc002xiz.2_Frame_Shift_Ins_p.T157fs|RALGAPB_uc002xja.1_Frame_Shift_Ins_p.T106fs	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	379					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						TGTCAGTACCACCCCCCCACAT	0.446			NA											7	123	---	---	---	---	NA	NA	NA	NA	NA
SLPI	6590	broad.mit.edu	37	20	43881730	43881731	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr20:43881730_43881731insG	uc002xnm.1	-	3	328_329	c.306_307insC	c.(304-309)CCCAATfs	p.P102fs		NM_003064	NP_003055	P03973	SLPI_HUMAN	secretory leukocyte peptidase inhibitor	102_103	Elastase inhibitory domain.|WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				TCACAGAAATTGGGGGGGTTAA	0.535	GBM(64;162 1089 31780 33427 34538)		NA											11	318	---	---	---	---	NA	NA	NA	NA	NA
OSBPL2	9885	broad.mit.edu	37	20	60854257	60854258	+	Frame_Shift_Ins	INS	-	-	C	rs79735057		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr20:60854257_60854258insC	uc002yck.1	+	7	738_739	c.536_537insC	c.(535-537)CACfs	p.H179fs	OSBPL2_uc002ycl.1_Frame_Shift_Ins_p.H167fs|OSBPL2_uc011aah.1_Frame_Shift_Ins_p.H87fs|OSBPL2_uc002ycm.1_5'UTR	NM_144498	NP_653081	Q9H1P3	OSBL2_HUMAN	oxysterol-binding protein-like protein 2 isoform	179					lipid transport		lipid binding			ovary(1)|central_nervous_system(1)	2	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			GTCAGTCACCACCCCCCCATCA	0.465			NA											9	176	---	---	---	---	NA	NA	NA	NA	NA
GRIK1	2897	broad.mit.edu	37	21	30959772	30959772	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr21:30959772delG	uc002yno.1	-	12	2171	c.1707delC	c.(1705-1707)TCCfs	p.S569fs	GRIK1_uc002ynn.2_Frame_Shift_Del_p.S554fs|GRIK1_uc011acs.1_Frame_Shift_Del_p.S569fs|GRIK1_uc011act.1_Frame_Shift_Del_p.S430fs|GRIK1_uc010glq.1_Frame_Shift_Del_p.S412fs	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	569	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GGTTGAGGAAGGAGAAAACGC	0.483			NA											44	84	---	---	---	---	NA	NA	NA	NA	NA
SH3BGR	6450	broad.mit.edu	37	21	40823994	40823995	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr21:40823994_40823995insG	uc002yya.2	+	1	215_216	c.161_162insG	c.(160-162)TTGfs	p.L54fs	SH3BGR_uc002yxz.2_Intron	NM_007341	NP_031367	P55822	SH3BG_HUMAN	SH3-binding domain and glutamic acid-rich	54					protein complex assembly	cytosol	SH3 domain binding|SH3/SH2 adaptor activity				0		all_cancers(19;1.16e-23)|all_epithelial(19;1.22e-20)|Prostate(19;2.55e-06)|Breast(209;0.0133)		STAD - Stomach adenocarcinoma(101;0.00151)		AGGGGTGTGTTGGGGGGAGTCC	0.554			NA											7	582	---	---	---	---	NA	NA	NA	NA	NA
DSCAM	1826	broad.mit.edu	37	21	41514614	41514615	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr21:41514614_41514615insG	uc002yyq.1	-	18	3728_3729	c.3276_3277insC	c.(3274-3279)CCCGAAfs	p.P1092fs	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1092_1093	Extracellular (Potential).|Fibronectin type-III 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGGACATTTTCGGGGGGGTAAC	0.406	Melanoma(134;970 1778 1785 21664 32388)		NA											12	826	---	---	---	---	NA	NA	NA	NA	NA
CECR2	27443	broad.mit.edu	37	22	18022285	18022286	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr22:18022285_18022286insC	uc010gqw.1	+	15	2513_2514	c.2387_2388insC	c.(2386-2388)GTCfs	p.V796fs	CECR2_uc010gqv.1_Frame_Shift_Ins_p.V655fs|CECR2_uc002zml.2_Frame_Shift_Ins_p.V655fs	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	838					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		AGACCACCTGTCCCCCCCAACC	0.609			NA											8	171	---	---	---	---	NA	NA	NA	NA	NA
MTMR3	8897	broad.mit.edu	37	22	30408493	30408494	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr22:30408493_30408494insC	uc003agv.3	+	13	1586_1587	c.1258_1259insC	c.(1258-1260)ACCfs	p.T420fs	MTMR3_uc003agu.3_Frame_Shift_Ins_p.T420fs|MTMR3_uc003agw.3_Frame_Shift_Ins_p.T420fs	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	420	Myotubularin phosphatase.				phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			CTGGGACCGCACCCCCCAGATT	0.545			NA											9	1197	---	---	---	---	NA	NA	NA	NA	NA
DDX17	10521	broad.mit.edu	37	22	38895454	38895455	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr22:38895454_38895455insC	uc003avy.3	-	3	591_592	c.488_489insG	c.(487-489)GGAfs	p.G163fs	DDX17_uc003avx.3_Frame_Shift_Ins_p.G163fs|DDX17_uc011anu.1_Frame_Shift_Ins_p.G76fs	NM_001098504	NP_001091974	Q92841	DDX17_HUMAN	DEAD box polypeptide 17 isoform 3	84					RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity			skin(3)|upper_aerodigestive_tract(1)	4	Melanoma(58;0.0286)					GACAAACATCTCCCCCCCTCAC	0.381	Ovarian(55;1085 1454 6392 21425)		NA											8	152	---	---	---	---	NA	NA	NA	NA	NA
TCF20	6942	broad.mit.edu	37	22	42610947	42610948	+	Frame_Shift_Ins	INS	-	-	G	rs138734341		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr22:42610947_42610948insG	uc003bcj.1	-	1	498_499	c.364_365insC	c.(364-366)CAGfs	p.Q122fs	TCF20_uc003bck.1_Frame_Shift_Ins_p.Q122fs|TCF20_uc003bnt.2_Frame_Shift_Ins_p.Q122fs	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	122				Q -> R (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						GCTGCTCCCCTGGGGGGGTCCA	0.564			NA											11	299	---	---	---	---	NA	NA	NA	NA	NA
SETD5	55209	broad.mit.edu	37	3	9517294	9517295	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr3:9517294_9517295insC	uc003brt.2	+	23	4283_4284	c.3848_3849insC	c.(3847-3849)AACfs	p.N1283fs	SETD5_uc003bru.2_Frame_Shift_Ins_p.N1185fs|SETD5_uc003brv.2_Frame_Shift_Ins_p.N1172fs|SETD5_uc010hck.2_Frame_Shift_Ins_p.N765fs|SETD5_uc003brx.2_Frame_Shift_Ins_p.N952fs	NM_001080517	NP_001073986	Q9C0A6	SETD5_HUMAN	SET domain containing 5	1283	Ser-rich.									ovary(2)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		AGACCTGGAAACCCCCCCTCTC	0.55			NA											7	184	---	---	---	---	NA	NA	NA	NA	NA
MLH1	4292	broad.mit.edu	37	3	37070348	37070349	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr3:37070348_37070349insC	uc003cgl.2	+	13	1543_1544	c.1483_1484insC	c.(1483-1485)ACCfs	p.T495fs	MLH1_uc011aye.1_Frame_Shift_Ins_p.T254fs|MLH1_uc011ayb.1_Frame_Shift_Ins_p.T254fs|MLH1_uc010hge.2_Frame_Shift_Ins_p.T495fs|MLH1_uc003cgn.3_Frame_Shift_Ins_p.T254fs|MLH1_uc011ayc.1_Frame_Shift_Ins_p.T397fs|MLH1_uc011ayd.1_Frame_Shift_Ins_p.T254fs|MLH1_uc003cgo.2_Frame_Shift_Ins_p.T254fs|MLH1_uc010hgi.1_Frame_Shift_Ins_p.T137fs|MLH1_uc010hgj.1_Frame_Shift_Ins_p.T137fs|MLH1_uc010hgk.2_Frame_Shift_Ins_p.T137fs|MLH1_uc010hgl.1_Frame_Shift_Ins_p.T70fs|MLH1_uc010hgn.2_Frame_Shift_Ins_p.T137fs|MLH1_uc010hgm.2_RNA|MLH1_uc010hgo.2_Frame_Shift_Ins_p.T137fs	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	495	Interaction with EXO1.				mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.T495A(1)|p.0?(1)		large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						TGCAGCTTGTACCCCCCGGAGA	0.47			1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				7	374	---	---	---	---	NA	NA	NA	NA	NA
MUC13	56667	broad.mit.edu	37	3	124646628	124646629	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr3:124646628_124646629insG	uc003ehq.1	-	2	285_286	c.261_262insC	c.(259-264)CCCATAfs	p.P87fs		NM_033049	NP_149038	Q9H3R2	MUC13_HUMAN	mucin 13, epithelial transmembrane	87_88	Thr-rich.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane					0						GTACTAATTATGGGGGGAGCAG	0.441			NA											7	713	---	---	---	---	NA	NA	NA	NA	NA
ATP13A3	79572	broad.mit.edu	37	3	194169249	194169250	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr3:194169249_194169250delTC	uc003fty.3	-	11	1488_1489	c.1086_1087delGA	c.(1084-1089)GGGACAfs	p.G362fs	ATP13A3_uc003ftz.1_Frame_Shift_Del_p.G68fs	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	362_363					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		ATAACAGTTGTCCCACAAAACA	0.351			NA											370	461	---	---	---	---	NA	NA	NA	NA	NA
FAM193A	8603	broad.mit.edu	37	4	2661592	2661593	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:2661592_2661593insC	uc010icl.2	+	8	1034_1035	c.683_684insC	c.(682-684)GACfs	p.D228fs	FAM193A_uc010ick.2_Frame_Shift_Ins_p.D428fs|FAM193A_uc003gfd.2_Frame_Shift_Ins_p.D228fs|FAM193A_uc011bvm.1_Frame_Shift_Ins_p.D252fs|FAM193A_uc011bvn.1_Frame_Shift_Ins_p.D228fs|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Frame_Shift_Ins_p.D82fs	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	228										ovary(3)	3						GGTATCATGGACCCCCCCGTCA	0.525			NA											18	584	---	---	---	---	NA	NA	NA	NA	NA
LGI2	55203	broad.mit.edu	37	4	25005320	25005321	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:25005320_25005321insC	uc003grf.2	-	8	1489_1490	c.1390_1391insG	c.(1390-1392)GCCfs	p.A464fs		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	464	EAR 6.					extracellular region					0		Breast(46;0.173)				CAGGGTCATGGCCCCCCGGGAT	0.515			NA											7	212	---	---	---	---	NA	NA	NA	NA	NA
ABCG2	9429	broad.mit.edu	37	4	89052270	89052271	+	Frame_Shift_Ins	INS	-	-	T	rs150450599	byFrequency	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:89052270_89052271insT	uc003hrg.2	-	5	966_967	c.473_474insA	c.(472-474)AACfs	p.N158fs	ABCG2_uc003hrh.2_Frame_Shift_Ins_p.N158fs|ABCG2_uc003hrf.2_Frame_Shift_Ins_p.N28fs	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G, member 2	158	ABC transporter.|Cytoplasmic (Potential).				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	TAATCCGTTCGTTTTTTTCATG	0.426			NA											8	699	---	---	---	---	NA	NA	NA	NA	NA
UNC5C	8633	broad.mit.edu	37	4	96140293	96140294	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:96140293_96140294insG	uc003htp.1	-	9	1625_1626	c.1471_1472insC	c.(1471-1473)CAAfs	p.Q491fs	UNC5C_uc010ilc.1_Frame_Shift_Ins_p.Q510fs|UNC5C_uc003htq.2_Frame_Shift_Ins_p.Q510fs	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	491	Cytoplasmic (Potential).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GAGGTCATCTTGGGGGGTGACA	0.505			NA											7	378	---	---	---	---	NA	NA	NA	NA	NA
CFI	3426	broad.mit.edu	37	4	110662158	110662159	+	Frame_Shift_Ins	INS	-	-	C	rs7437875	byFrequency	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:110662158_110662159insC	uc003hzr.3	-	13	1850_1851	c.1642_1643insG	c.(1642-1644)GAAfs	p.E548fs	CFI_uc003hzq.2_Frame_Shift_Ins_p.E345fs|CFI_uc011cft.1_Frame_Shift_Ins_p.E556fs|CFI_uc003hzs.3_Frame_Shift_Ins_p.E541fs	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	548	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		TCCACAGTTTTCCCCCCAACTC	0.465			NA											8	429	---	---	---	---	NA	NA	NA	NA	NA
EGF	1950	broad.mit.edu	37	4	110909773	110909774	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr4:110909773_110909774insC	uc003hzy.3	+	18	3094_3095	c.2642_2643insC	c.(2641-2643)TGCfs	p.C881fs	EGF_uc011cfu.1_Frame_Shift_Ins_p.C839fs|EGF_uc011cfv.1_Frame_Shift_Ins_p.C881fs|EGF_uc010imk.2_Intron	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	881	EGF-like 7; calcium-binding (Potential).|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	GTCCCAGTGTGCCCCCCTGCCT	0.47			NA											7	551	---	---	---	---	NA	NA	NA	NA	NA
FYB	2533	broad.mit.edu	37	5	39202090	39202091	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:39202090_39202091insC	uc003jls.2	-	1	1039_1040	c.972_973insG	c.(970-975)GGGCCAfs	p.G324fs	FYB_uc003jlt.2_Frame_Shift_Ins_p.G324fs|FYB_uc003jlu.2_Frame_Shift_Ins_p.G324fs|FYB_uc011cpl.1_Frame_Shift_Ins_p.G334fs	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	324_325					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			TGGCCCCATGGCCCCCCCACTG	0.54			NA											9	166	---	---	---	---	NA	NA	NA	NA	NA
C6	729	broad.mit.edu	37	5	41181559	41181560	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:41181559_41181560insC	uc003jmk.2	-	7	1038_1039	c.828_829insG	c.(826-831)GGGAGCfs	p.G276fs	C6_uc003jml.1_Frame_Shift_Ins_p.G276fs	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	276_277	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CTGAAAGAGCTCCCCCCCTGAC	0.376			NA											11	181	---	---	---	---	NA	NA	NA	NA	NA
MAP1B	4131	broad.mit.edu	37	5	71495076	71495077	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:71495076_71495077insC	uc003kbw.3	+	5	6135_6136	c.5894_5895insC	c.(5893-5895)AGCfs	p.S1965fs	MAP1B_uc010iyw.1_Frame_Shift_Ins_p.S1982fs|MAP1B_uc010iyx.1_Frame_Shift_Ins_p.S1839fs|MAP1B_uc010iyy.1_Frame_Shift_Ins_p.S1839fs	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1965	MAP1B 6.					microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AAGACCACCAGCCCCCCCGAAG	0.485	Melanoma(17;367 822 11631 31730 47712)		NA											9	241	---	---	---	---	NA	NA	NA	NA	NA
RASGRF2	5924	broad.mit.edu	37	5	80369227	80369228	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr5:80369227_80369228insC	uc003kha.1	+	5	843_844	c.843_844insC	c.(841-846)AAGCCCfs	p.K281fs	RASGRF2_uc011ctn.1_RNA|RASGRF2_uc003khb.1_Frame_Shift_Ins_p.K109fs	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	281_282	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		GCTCCAAGAAGCCCCCCATCAG	0.49			NA											13	68	---	---	---	---	NA	NA	NA	NA	NA
EXOC2	55770	broad.mit.edu	37	6	637793	637794	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:637793_637794insG	uc003mtd.2	-	2	159_160	c.25_26insC	c.(25-27)CTTfs	p.L9fs	EXOC2_uc003mte.2_Frame_Shift_Ins_p.L9fs|EXOC2_uc011dho.1_Intron	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	9	IPT/TIG.				exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		GCCGGTCACAAGGGGGGGTTGT	0.485			NA											10	305	---	---	---	---	NA	NA	NA	NA	NA
PHACTR1	221692	broad.mit.edu	37	6	13206134	13206135	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:13206134_13206135insG	uc010jpc.2	+	8	1084_1085	c.752_753insG	c.(751-753)GTGfs	p.V251fs	PHACTR1_uc011dir.1_Frame_Shift_Ins_p.V320fs|PHACTR1_uc003nag.1_Frame_Shift_Ins_p.V251fs|PHACTR1_uc003nah.1_Frame_Shift_Ins_p.V251fs	NM_030948	NP_112210	Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	251						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			TGTATGCCCGTGGGGGGGCCAG	0.599			NA											7	206	---	---	---	---	NA	NA	NA	NA	NA
DCDC2	51473	broad.mit.edu	37	6	24205282	24205283	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:24205282_24205283insC	uc003ndx.2	-	8	1272_1273	c.970_971insG	c.(970-972)GCAfs	p.A324fs	DCDC2_uc003ndy.2_Frame_Shift_Ins_p.A324fs|DCDC2_uc003ndw.2_Frame_Shift_Ins_p.A75fs	NM_016356	NP_057440	Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	324					cellular defense response|intracellular signal transduction|neuron migration					ovary(1)	1		Ovarian(999;0.101)				GACTTCTGCTGCCCCCCGTGTT	0.411			NA											14	1246	---	---	---	---	NA	NA	NA	NA	NA
OR5V1	81696	broad.mit.edu	37	6	29323407	29323407	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:29323407delC	uc011dlo.1	-	1	648	c.566delG	c.(565-567)TGTfs	p.C189fs		NM_030876	NP_110503	Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|kidney(1)	4						AGTGTTTCCACAAGACAAGAT	0.443	Ovarian(32;43 883 21137 32120 42650)		NA											138	496	---	---	---	---	NA	NA	NA	NA	NA
MOG	4340	broad.mit.edu	37	6	29627216	29627217	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:29627216_29627217insC	uc003nnf.2	+	2	387_388	c.209_210insC	c.(208-210)CGCfs	p.R70fs	MOG_uc003qzk.1_Frame_Shift_Ins_p.R70fs|MOG_uc010kle.1_Intron|MOG_uc010klf.1_Intron|MOG_uc003nmy.1_Frame_Shift_Ins_p.R70fs|MOG_uc003nmz.2_Frame_Shift_Ins_p.R70fs|MOG_uc011dlt.1_Intron|MOG_uc003nna.2_Intron|MOG_uc011dlu.1_Intron|MOG_uc011dlv.1_Intron|MOG_uc003nnd.2_Frame_Shift_Ins_p.R70fs|MOG_uc003nne.2_Frame_Shift_Ins_p.R70fs|MOG_uc003nng.2_Frame_Shift_Ins_p.R70fs|MOG_uc003nnh.2_Frame_Shift_Ins_p.R70fs|MOG_uc003nni.2_Frame_Shift_Ins_p.R70fs|MOG_uc003nnj.2_Frame_Shift_Ins_p.R70fs|MOG_uc003nnk.2_Frame_Shift_Ins_p.R70fs	NM_206809	NP_996532	Q16653	MOG_HUMAN	myelin oligodendrocyte glycoprotein isoform	70	Ig-like V-type.|Extracellular (Potential).				cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)	1						GGGTGGTACCGCCCCCCCTTCT	0.569			NA											9	209	---	---	---	---	NA	NA	NA	NA	NA
UHRF1BP1	54887	broad.mit.edu	37	6	34791081	34791082	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:34791081_34791082insC	uc003oju.3	+	4	528_529	c.294_295insC	c.(292-297)CGGCCCfs	p.R98fs	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	98_99										ovary(3)	3						AGGATCCTCGGCCCCCCAATGG	0.446			NA											18	886	---	---	---	---	NA	NA	NA	NA	NA
MAPK14	1432	broad.mit.edu	37	6	36068005	36068006	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:36068005_36068006insC	uc003olp.2	+	9	1204_1205	c.723_724insC	c.(721-726)ACACCCfs	p.T241fs	MAPK14_uc003olo.2_Intron|MAPK14_uc003olq.2_Intron|MAPK14_uc003olr.2_Intron|MAPK14_uc011dti.1_Intron	NM_001315	NP_001306	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14 isoform 1	241_242	Protein kinase.				activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			ovary(2)|stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	6						TGACAGGAACACCCCCCGCTTA	0.426	Pancreas(20;8 363 26997 32430 36377 43317 49243 50560 51947)|Colon(176;951 1093 20177 30266 32328 34418 35271 44052 51610)		NA											13	368	---	---	---	---	NA	NA	NA	NA	NA
RUNX2	860	broad.mit.edu	37	6	45514855	45514856	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:45514855_45514856insG	uc011dvx.1	+	9	1589_1590	c.1379_1380insG	c.(1378-1380)CCGfs	p.P460fs	RUNX2_uc011dvy.1_Frame_Shift_Ins_p.P438fs|RUNX2_uc003oxt.2_Frame_Shift_Ins_p.P446fs	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	460	Pro/Ser/Thr-rich.|Interaction with MYST4.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						CCCATGGTGCCGGGGGGAGACC	0.545			NA											8	208	---	---	---	---	NA	NA	NA	NA	NA
REV3L	5980	broad.mit.edu	37	6	111693903	111693904	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr6:111693903_111693904insG	uc003puy.3	-	13	5977_5978	c.5654_5655insC	c.(5653-5655)CCAfs	p.P1885fs	REV3L_uc003pux.3_Frame_Shift_Ins_p.P1807fs|REV3L_uc003puz.3_Frame_Shift_Ins_p.P1807fs	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	1885	Mediates interaction with MAD2L2.				DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CTTCCCTACTTGGGGGGGACAT	0.431			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					8	317	---	---	---	---	NA	NA	NA	NA	NA
GRM3	2913	broad.mit.edu	37	7	86415681	86415682	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:86415681_86415682insC	uc003uid.2	+	3	1672_1673	c.573_574insC	c.(571-576)GTGCCCfs	p.V191fs	GRM3_uc010lef.2_Frame_Shift_Ins_p.V189fs|GRM3_uc010leg.2_Frame_Shift_Ins_p.V63fs|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	191_192	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	CCAGGACCGTGCCCCCCGACTT	0.564	GBM(52;969 1098 3139 52280)		NA											7	211	---	---	---	---	NA	NA	NA	NA	NA
ZCWPW1	55063	broad.mit.edu	37	7	100000150	100000151	+	Frame_Shift_Ins	INS	-	-	T			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:100000150_100000151insT	uc003uut.2	-	16	1707_1708	c.1459_1460insA	c.(1459-1461)ACCfs	p.T487fs	ZCWPW1_uc011kjq.1_Frame_Shift_Ins_p.T367fs|ZCWPW1_uc003uur.2_Intron|ZCWPW1_uc003uus.2_Frame_Shift_Ins_p.T367fs|ZCWPW1_uc011kjr.1_Intron|ZCWPW1_uc011kjp.1_Intron	NM_017984	NP_060454	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	487							zinc ion binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCTTGGCTTGGTTTTTTGGGTC	0.48			NA											7	2142	---	---	---	---	NA	NA	NA	NA	NA
SRRT	51593	broad.mit.edu	37	7	100479331	100479332	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:100479331_100479332insG	uc003uwy.2	+	5	571_572	c.303_304insG	c.(301-306)GCTGGGfs	p.A101fs	SRRT_uc010lhl.1_Frame_Shift_Ins_p.A101fs|SRRT_uc003uxa.2_Frame_Shift_Ins_p.A101fs|SRRT_uc003uwz.2_Frame_Shift_Ins_p.A101fs	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	101_102					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						TGCCCTATGCTGGGGGGGGTGG	0.609			NA											8	83	---	---	---	---	NA	NA	NA	NA	NA
AP1S1	1174	broad.mit.edu	37	7	100802404	100802405	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:100802404_100802405insG	uc003uxv.3	+	4	466_467	c.356_357insG	c.(355-357)ATGfs	p.M119fs		NM_001283	NP_001274	P61966	AP1S1_HUMAN	adaptor-related protein complex 1, sigma 1	119					intracellular protein transport|post-Golgi vesicle-mediated transport|receptor-mediated endocytosis|regulation of defense response to virus by virus|response to virus|viral reproduction	AP-1 adaptor complex|coated pit|cytosol|lysosomal membrane	protein binding|protein transporter activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					GAGTTTTTGATGGGGGGGGATG	0.564			NA											7	49	---	---	---	---	NA	NA	NA	NA	NA
C7orf58	79974	broad.mit.edu	37	7	120911387	120911388	+	Frame_Shift_Ins	INS	-	-	A	rs141494536	byFrequency	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:120911387_120911388insA	uc003vjq.3	+	22	3218_3219	c.2771_2772insA	c.(2770-2772)GCAfs	p.A924fs		NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	924						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					CTGGATACTGCAAAAAAACATG	0.351			NA											8	259	---	---	---	---	NA	NA	NA	NA	NA
EXOC4	60412	broad.mit.edu	37	7	133682284	133682285	+	Frame_Shift_Ins	INS	-	-	C	rs34608222	byFrequency	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:133682284_133682285insC	uc003vrk.2	+	15	2281_2282	c.2246_2247insC	c.(2245-2247)CTCfs	p.L749fs	EXOC4_uc011kpo.1_Frame_Shift_Ins_p.L648fs|EXOC4_uc003vrl.2_Frame_Shift_Ins_p.L359fs|EXOC4_uc011kpp.1_Frame_Shift_Ins_p.L281fs|EXOC4_uc011kpq.1_Frame_Shift_Ins_p.L37fs	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	749					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				AACACGGATCTCCCCCCAGTGT	0.46			NA											8	355	---	---	---	---	NA	NA	NA	NA	NA
UBN2	254048	broad.mit.edu	37	7	138946363	138946364	+	Frame_Shift_Ins	INS	-	-	G	rs140343844	by1000genomes	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:138946363_138946364insG	uc011kqr.1	+	6	1271_1272	c.1271_1272insG	c.(1270-1272)TCGfs	p.S424fs	UBN2_uc003vuv.2_Frame_Shift_Ins_p.S147fs	NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	424										ovary(1)|skin(1)	2						CTATCTGAGTCGGGGGGTGAAA	0.49			NA											7	208	---	---	---	---	NA	NA	NA	NA	NA
TRPV5	56302	broad.mit.edu	37	7	142612493	142612494	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr7:142612493_142612494insC	uc003wby.1	-	10	1533_1534	c.1269_1270insG	c.(1267-1272)GGGCCAfs	p.G423fs		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	423_424	Helical; (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					ACATGGAATGGCCCCCCAAGAA	0.505			NA											8	420	---	---	---	---	NA	NA	NA	NA	NA
ENTPD4	9583	broad.mit.edu	37	8	23294483	23294484	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:23294483_23294484insC	uc003xdl.2	-	10	1501_1502	c.1337_1338insG	c.(1336-1338)GGAfs	p.G446fs	ENTPD4_uc011kzu.1_Frame_Shift_Ins_p.G438fs|ENTPD4_uc003xdm.2_Frame_Shift_Ins_p.G438fs|ENTPD4_uc011kzv.1_Frame_Shift_Ins_p.G446fs	NM_004901	NP_004892	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	446	Lumenal (Potential).				UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			ovary(1)|kidney(1)	2		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		CATTGTAGTCTCCCCCCATTCG	0.5			NA											14	441	---	---	---	---	NA	NA	NA	NA	NA
ARFGEF1	10565	broad.mit.edu	37	8	68128855	68128856	+	Frame_Shift_Ins	INS	-	-	G	rs142098461		TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:68128855_68128856insG	uc003xxo.1	-	33	5045_5046	c.4655_4656insC	c.(4654-4656)CCAfs	p.P1552fs	ARFGEF1_uc003xxl.1_Frame_Shift_Ins_p.P1006fs|ARFGEF1_uc003xxn.1_Frame_Shift_Ins_p.P535fs	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1552					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GAGATGGAGGTGGGGGGGCAGT	0.421			NA											23	267	---	---	---	---	NA	NA	NA	NA	NA
KCNB2	9312	broad.mit.edu	37	8	73480396	73480397	+	Frame_Shift_Ins	INS	-	-	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr8:73480396_73480397insA	uc003xzb.2	+	2	1015_1016	c.427_428insA	c.(427-429)CAAfs	p.Q143fs		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	143	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CAGATATCATCAAAAAAAAGAA	0.446			NA											7	614	---	---	---	---	NA	NA	NA	NA	NA
ABCA1	19	broad.mit.edu	37	9	107593322	107593323	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:107593322_107593323insC	uc004bcl.2	-	14	2088_2089	c.1775_1776insG	c.(1774-1776)GGCfs	p.G592fs		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	592	Extracellular.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGTAGGCGAAGCCCCCCCAGAC	0.54			NA											10	227	---	---	---	---	NA	NA	NA	NA	NA
BAT2L1	84726	broad.mit.edu	37	9	134349850	134349851	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chr9:134349850_134349851delCT	uc004can.3	+	15	2389_2390	c.2334_2335delCT	c.(2332-2337)AGCTCTfs	p.S778fs	BAT2L1_uc010mzj.1_Frame_Shift_Del_p.S361fs|BAT2L1_uc004cao.3_Frame_Shift_Del_p.S136fs	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	778_779							protein binding				0						GGAATGAAAGCTCTTTCTCTGC	0.475			NA											21	87	---	---	---	---	NA	NA	NA	NA	NA
PRRG1	5638	broad.mit.edu	37	X	37312610	37312611	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:37312610_37312611insC	uc004ddn.2	+	5	646_647	c.393_394insC	c.(391-396)CCACCCfs	p.P131fs	PRRG1_uc004ddo.2_Frame_Shift_Ins_p.P131fs	NM_000950	NP_000941	O14668	TMG1_HUMAN	proline rich Gla (G-carboxyglutamic acid) 1	131_132	Cytoplasmic (Potential).|Poly-Pro.					extracellular region|integral to plasma membrane	calcium ion binding			ovary(1)|breast(1)	2						TTATCACCCCACCCCCCCCACC	0.485			NA											8	105	---	---	---	---	NA	NA	NA	NA	NA
USP9X	8239	broad.mit.edu	37	X	40982956	40982957	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:40982956_40982957insC	uc004dfb.2	+	2	708_709	c.75_76insC	c.(73-78)CAGCCCfs	p.Q25fs	USP9X_uc004dfc.2_Frame_Shift_Ins_p.Q25fs	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	25_26					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						GACAGTCTCAGCCCCCCCTCCA	0.426	Ovarian(172;1807 2695 35459 49286)		NA											9	138	---	---	---	---	NA	NA	NA	NA	NA
Unknown	0	broad.mit.edu	37	X	48159107	48159108	+	Frame_Shift_Ins	INS	-	-	G	rs41305745	by1000genomes	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:48159107_48159108insG	uc010nib.1	-	6	512_513	c.425_426insC	c.(424-426)CCGfs	p.P142fs		NM_174962	NP_777622			synovial sarcoma, X breakpoint 9												NA						TTGGTTTTCCCGGGGGGCACAG	0.49			NA											9	344	---	---	---	---	NA	NA	NA	NA	NA
SSX3	10214	broad.mit.edu	37	X	48209462	48209463	+	Frame_Shift_Ins	INS	-	-	G	rs6651589	byFrequency	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:48209462_48209463insG	uc004djd.1	-	6	519_520	c.425_426insC	c.(424-426)CCGfs	p.P142fs	SSX3_uc004dje.2_Frame_Shift_Ins_p.P142fs	NM_021014	NP_066294	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3 isoform a	142					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding				0						TTGGTTTTCCCGGGGGGCACAG	0.495	Colon(37;227 826 19399 40970 48007)		NA											8	462	---	---	---	---	NA	NA	NA	NA	NA
KIAA2022	340533	broad.mit.edu	37	X	73963268	73963269	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:73963268_73963269insC	uc004eby.2	-	3	1740_1741	c.1123_1124insG	c.(1123-1125)GAGfs	p.E375fs		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	375					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TTTATCTTCCTCCCCCCAGATG	0.475			NA											13	642	---	---	---	---	NA	NA	NA	NA	NA
BCORL1	63035	broad.mit.edu	37	X	129146962	129146963	+	Frame_Shift_Ins	INS	-	-	G	rs141901231	byFrequency	TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:129146962_129146963insG	uc004evb.1	+	4	328_329	c.214_215insG	c.(214-216)CGGfs	p.R72fs	BCORL1_uc010nrd.1_5'UTR	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	72					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						CAGCAATGCCCGGGGGGCAGAC	0.569			NA											10	297	---	---	---	---	NA	NA	NA	NA	NA
GPR112	139378	broad.mit.edu	37	X	135426885	135426886	+	Frame_Shift_Ins	INS	-	-	A			TCGA-64-1678-01A-01W-0928-08	TCGA-64-1678-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	42e3b592-b57f-4b18-8f62-e7b0a9c0f1db	c705e3ce-3e8c-497a-8091-04fd4d369afd	g.chrX:135426885_135426886insA	uc004ezu.1	+	6	1311_1312	c.1020_1021insA	c.(1018-1023)ATGAAAfs	p.M340fs	GPR112_uc010nsb.1_Frame_Shift_Ins_p.M135fs|GPR112_uc010nsc.1_Frame_Shift_Ins_p.M107fs	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	340_341	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CCAATTCCATGAAAAAAACGAA	0.386			NA											8	641	---	---	---	---	NA	NA	NA	NA	NA
