Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CCDC27	148870	broad.mit.edu	37	1	3677924	3677924	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr1:3677924C>T	uc001akv.2	+	5	872	c.791C>T	c.(790-792)GCC>GTC	p.A264V		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	264	Potential.									skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		GAGAGGGAGGCCCTGAAGATG	0.587			NA											39	149					0	0	0.004878	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12855612	12855612	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr1:12855612T>A	uc001auj.1	+	4	995	c.892T>A	c.(892-894)TTG>ATG	p.L298M		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	298											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTTGGAGAACTTGGAATTAAC	0.463			NA											36	139					0	0	0.01441	0	0
CCDC21	64793	broad.mit.edu	37	1	26603225	26603225	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr1:26603225A>G	uc001bls.1	+	13	2233	c.2102A>G	c.(2101-2103)AAT>AGT	p.N701S	SH3BGRL3_uc001blu.2_5'Flank|CCDC21_uc001blr.2_Missense_Mutation_p.N701S|CCDC21_uc010ofa.1_Missense_Mutation_p.N650S|CCDC21_uc001blt.1_Missense_Mutation_p.N133S	NM_022778	NP_073615	Q6P2H3	CEP85_HUMAN	coiled-coil domain containing 21	701						centrosome|nucleolus|spindle pole					0		all_cancers(24;7e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.6e-26)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;9.48e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00155)|GBM - Glioblastoma multiforme(114;0.00917)|READ - Rectum adenocarcinoma(331;0.0649)		CATGACCCCAATCTCTCCCTG	0.592			NA											13	62					0	0	0.013537	0	0
ERMAP	114625	broad.mit.edu	37	1	43296552	43296552	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr1:43296552C>T	uc001cic.1	+	4	469	c.199C>T	c.(199-201)CGG>TGG	p.R67W	ERMAP_uc010ojw.1_Missense_Mutation_p.R128W|ERMAP_uc001cid.1_Intron|ERMAP_uc001cie.1_Missense_Mutation_p.R67W|ERMAP_uc001cif.1_5'UTR	NM_001017922	NP_001017922	Q96PL5	ERMAP_HUMAN	erythroblast membrane-associated protein	67	Ig-like V-type.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GAGGTGGCTGCGGTCCCCATT	0.632			NA											9	38					0	0	0.006214	0	0
ST6GALNAC3	256435	broad.mit.edu	37	1	77093218	77093218	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr1:77093218C>A	uc001dhh.2	+	4	868	c.705C>A	c.(703-705)TAC>TAA	p.Y235*	ST6GALNAC3_uc010orh.1_Intron	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	235	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						TTCACGTCTACGGGATGATAA	0.408			NA											3	77					0.004672	0.00495688	0.004672	1	0
HRNR	388697	broad.mit.edu	37	1	152187481	152187481	+	Silent	SNP	A	A	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr1:152187481A>C	uc001ezt.1	-	3	6700	c.6624T>G	c.(6622-6624)TCT>TCG	p.S2208S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2208	24.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACGGCTGGAAGAACGACCTG	0.592			NA											6	446					0	0	0.004007	0	0
OR10J1	26476	broad.mit.edu	37	1	159410483	159410483	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr1:159410483G>A	uc010piv.1	+	1	935	c.935G>A	c.(934-936)TGC>TAC	p.C312Y	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	312	Cytoplasmic (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					GATGCTCTGTGCAGGGCTGTT	0.483			NA											19	77					0	0	0.007413	0	0
TNN	63923	broad.mit.edu	37	1	175097855	175097855	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr1:175097855C>G	uc001gkl.1	+	15	3416	c.3303C>G	c.(3301-3303)GAC>GAG	p.D1101E		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	1101	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TGTACTGTGACATGGAAACGG	0.602			NA											34	187					0	0	0.003271	0	0
PARP1	142	broad.mit.edu	37	1	226549183	226549183	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr1:226549183T>C	uc001hqd.3	-	23	3194	c.3023A>G	c.(3022-3024)AAT>AGT	p.N1008S		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	1008	PARP catalytic.				cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		GGTCTTAAAATTGAATTTCAG	0.478			NA						Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					16	44					0	0	0.00499	0	0
RYR2	6262	broad.mit.edu	37	1	237819148	237819148	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr1:237819148G>C	uc001hyl.1	+	53	8113	c.7993G>C	c.(7993-7995)GCA>CCA	p.A2665P		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2665	Modulator (Potential).|Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTTCAAACTGGCACTGCCTTG	0.408			NA											5	8					0	0	0.000602	0	0
GAD2	2572	broad.mit.edu	37	10	26570005	26570005	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr10:26570005G>C	uc001isp.2	+	12	1728	c.1225G>C	c.(1225-1227)GTT>CTT	p.V409L	GAD2_uc001isq.2_Missense_Mutation_p.V409L	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	409					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	TGCTCTCCTGGTTAGAGAAGA	0.463			NA											28	132					0	0	0.008361	0	0
COL17A1	1308	broad.mit.edu	37	10	105833976	105833976	+	Silent	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr10:105833976G>A	uc001kxr.2	-	6	514	c.345C>T	c.(343-345)GGC>GGT	p.G115G	COL17A1_uc010qqv.1_Intron|COL17A1_uc009xxp.1_Silent_p.G115G	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	115	Cytoplasmic (Potential).|Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GAGAAGAGTTGCCACTGGAGC	0.478			NA											36	177					0	0	0.00874	0	0
CHST1	8534	broad.mit.edu	37	11	45671907	45671907	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr11:45671907G>T	uc001mys.1	-	4	1238	c.567C>A	c.(565-567)AAC>AAA	p.N189K		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	189	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		CCACGGTCAGGTTGAGTAGCC	0.721			NA											13	62					7.93312e-07	9.39022e-07	0.00245	1	0
OR5D14	219436	broad.mit.edu	37	11	55563901	55563901	+	Silent	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr11:55563901G>T	uc010rim.1	+	1	870	c.870G>T	c.(868-870)CTG>CTT	p.L290L		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	290	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				TGAACCCTCTGATCTACAGCC	0.408			NA											8	25					0.000442599	0.000478337	0.006214	1	0
AHNAK	79026	broad.mit.edu	37	11	62293403	62293403	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr11:62293403T>A	uc001ntl.2	-	5	8786	c.8486A>T	c.(8485-8487)CAT>CTT	p.H2829L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2829					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AGTCTTAAAATGCATCTCTGG	0.428			NA											70	169					0	0	0.01441	0	0
C11orf2	738	broad.mit.edu	37	11	64879032	64879032	+	Silent	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr11:64879032G>A	uc001ocr.1	+	10	2362	c.2322G>A	c.(2320-2322)GTG>GTA	p.V774V	TM7SF2_uc001oct.2_5'Flank|TM7SF2_uc010rny.1_5'Flank|TM7SF2_uc001ocu.2_5'Flank|TM7SF2_uc001ocv.2_5'Flank|C11orf2_uc001ocs.1_Silent_p.V650V	NM_013265	NP_037397	Q9UID3	FFR_HUMAN	chromosome 11 open reading frame 2	774					lipid transport|protein transport	Golgi apparatus|integral to membrane					0						AGCCCAGTGTGGTTGAGGTCA	0.652			NA											19	52					0	0	0.008871	0	0
TM7SF2	7108	broad.mit.edu	37	11	64882511	64882512	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr11:64882511_64882512CC>AA	uc001oct.2	+	7	997_998	c.850_851CC>AA	c.(850-852)CCC>AAC	p.P284N	TM7SF2_uc010rny.1_Missense_Mutation_p.P168N|TM7SF2_uc001ocu.2_Missense_Mutation_p.P284N|TM7SF2_uc001ocv.2_Missense_Mutation_p.P305N|uc009yqb.1_5'Flank	NM_003273	NP_003264	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	284					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			ovary(1)	1						CCACCCGCAGCCCCTGGGGTTG	0.614			NA											19	208					0	0	0.004672	0	0
TM7SF2	7108	broad.mit.edu	37	11	64882533	64882533	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr11:64882533C>T	uc001oct.2	+	7	1019	c.872C>T	c.(871-873)TCT>TTT	p.S291F	TM7SF2_uc010rny.1_Missense_Mutation_p.S175F|TM7SF2_uc001ocu.2_Missense_Mutation_p.S291F|TM7SF2_uc001ocv.2_Missense_Mutation_p.S312F|uc009yqb.1_5'Flank	NM_003273	NP_003264	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	291	Helical; (Potential).				cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			ovary(1)	1						CCCATGGCCTCTGTCATCTGC	0.612			NA											40	177					0	0	0.009718	0	0
MAP3K11	4296	broad.mit.edu	37	11	65375459	65375459	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr11:65375459C>T	uc001oew.2	-	3	1496	c.1003G>A	c.(1003-1005)GCT>ACT	p.A335T	MAP3K11_uc001oev.2_5'Flank|MAP3K11_uc010rol.1_Missense_Mutation_p.A78T|MAP3K11_uc001oex.1_5'UTR	NM_002419	NP_002410	Q16584	M3K11_HUMAN	mitogen-activated protein kinase kinase kinase	335	Protein kinase.				activation of JUN kinase activity|cell proliferation|G1 phase of mitotic cell cycle|microtubule-based process|positive regulation of JNK cascade|protein autophosphorylation	centrosome|microtubule	ATP binding|JUN kinase kinase kinase activity|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity			breast(3)|lung(1)|central_nervous_system(1)|skin(1)	6						TTGTTAACAGCTACGCCATAG	0.607			NA											31	114					0	0	0.009535	0	0
LRRC32	2615	broad.mit.edu	37	11	76371718	76371718	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr11:76371718C>T	uc001oxq.3	-	3	1162	c.919G>A	c.(919-921)GGG>AGG	p.G307R	LRRC32_uc001oxr.3_Missense_Mutation_p.G307R|LRRC32_uc010rsf.1_Missense_Mutation_p.G307R	NM_005512	NP_005503	Q14392	LRC32_HUMAN	leucine rich repeat containing 32 precursor	307	Extracellular (Potential).					integral to plasma membrane					0						CTGGCATTCCCGCTGGGGGCT	0.622			NA											21	52					0	0	0.014323	0	0
CAPN5	726	broad.mit.edu	37	11	76825355	76825355	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr11:76825355G>A	uc001oxx.2	+	5	759	c.574G>A	c.(574-576)GGT>AGT	p.G192S	CAPN5_uc009yup.2_Missense_Mutation_p.G232S|CAPN5_uc009yuq.2_Missense_Mutation_p.G228S|CAPN5_uc001oxy.2_Missense_Mutation_p.G232S	NM_004055	NP_004046	O15484	CAN5_HUMAN	calpain 5	192	Calpain catalytic.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity				0						CTTCACGGGTGGTGTTTCTGA	0.567			NA									OREG0021255	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	161	527					0	0	0.01441	0	0
CAPN5	726	broad.mit.edu	37	11	76826513	76826513	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr11:76826513G>A	uc001oxx.2	+	6	957	c.772G>A	c.(772-774)GAT>AAT	p.D258N	CAPN5_uc009yup.2_Missense_Mutation_p.D298N|CAPN5_uc009yuq.2_Missense_Mutation_p.D294N|CAPN5_uc001oxy.2_Missense_Mutation_p.D298N	NM_004055	NP_004046	O15484	CAN5_HUMAN	calpain 5	258	Calpain catalytic.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity				0						CGCCGTCACTGATGTGCGCAA	0.642			NA											19	53					0	0	0.007413	0	0
CAPN5	726	broad.mit.edu	37	11	76826613	76826613	+	Nonsense_Mutation	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr11:76826613G>A	uc001oxx.2	+	6	1057	c.872G>A	c.(871-873)TGG>TAG	p.W291*	CAPN5_uc009yup.2_Nonsense_Mutation_p.W331*|CAPN5_uc009yuq.2_Nonsense_Mutation_p.W327*|CAPN5_uc001oxy.2_Nonsense_Mutation_p.W331*	NM_004055	NP_004046	O15484	CAN5_HUMAN	calpain 5	291	Calpain catalytic.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity				0						GAGCGGGAGTGGAACGGGCCC	0.652			NA											7	30					0	0	0.004482	0	0
CAPN5	726	broad.mit.edu	37	11	76826625	76826625	+	Nonsense_Mutation	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr11:76826625G>A	uc001oxx.2	+	6	1069	c.884G>A	c.(883-885)TGG>TAG	p.W295*	CAPN5_uc009yup.2_Nonsense_Mutation_p.W335*|CAPN5_uc009yuq.2_Nonsense_Mutation_p.W331*|CAPN5_uc001oxy.2_Nonsense_Mutation_p.W335*	NM_004055	NP_004046	O15484	CAN5_HUMAN	calpain 5	295	Calpain catalytic.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity				0						AACGGGCCCTGGAGTGACACG	0.662			NA											5	26					0	0	0.001168	0	0
CAPN5	726	broad.mit.edu	37	11	76829344	76829344	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr11:76829344G>C	uc001oxx.2	+	8	1298	c.1113G>C	c.(1111-1113)CAG>CAC	p.Q371H	CAPN5_uc009yup.2_Missense_Mutation_p.Q411H|CAPN5_uc009yuq.2_Missense_Mutation_p.Q407H|CAPN5_uc001oxy.2_Missense_Mutation_p.Q411H|CAPN5_uc001oya.2_5'Flank	NM_004055	NP_004046	O15484	CAN5_HUMAN	calpain 5	371	Domain III.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity				0						ACCCGCGACAGAACCGCGGTG	0.632			NA											13	51					0	0	0.00245	0	0
CAPN5	726	broad.mit.edu	37	11	76830106	76830106	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr11:76830106G>A	uc001oxx.2	+	9	1383	c.1198G>A	c.(1198-1200)GAA>AAA	p.E400K	CAPN5_uc009yup.2_Missense_Mutation_p.E440K|CAPN5_uc009yuq.2_Missense_Mutation_p.E436K|CAPN5_uc001oxy.2_Missense_Mutation_p.E440K|CAPN5_uc001oya.2_5'Flank	NM_004055	NP_004046	O15484	CAN5_HUMAN	calpain 5	400	Domain III.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity				0						GCCAGAAGATGAAGTCCTGAT	0.368			NA											14	36					0	0	0.006122	0	0
SLC36A4	120103	broad.mit.edu	37	11	92918921	92918921	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr11:92918921C>A	uc001pdn.2	-	2	212	c.115G>T	c.(115-117)GAA>TAA	p.E39*	SLC36A4_uc001pdm.2_5'UTR	NM_152313	NP_689526	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid	39					L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TGCTCATGTTCTTCATCTGAT	0.348			NA											8	17					0.000157383	0.000172231	0.00308	1	0
PCSK7	9159	broad.mit.edu	37	11	117098010	117098010	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr11:117098010G>C	uc001pqr.2	-	5	833	c.632C>G	c.(631-633)TCT>TGT	p.S211C		NM_004716	NP_004707	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	211	Catalytic.|Extracellular (Potential).				peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		AGGGTCATTAGAGTTGAGGTC	0.557			NA	T	IGH@	MLCLS								45	201					0	0	0.01441	0	0
IGSF9B	22997	broad.mit.edu	37	11	133789732	133789732	+	Silent	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr11:133789732G>A	uc001qgx.3	-	18	4119	c.3888C>T	c.(3886-3888)GAC>GAT	p.D1296D		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1296	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CGTCCAAGCTGTCCCCAGGCC	0.677			NA											10	45					0	0	0.013537	0	0
PZP	5858	broad.mit.edu	37	12	9303303	9303303	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr12:9303303G>T	uc001qvl.2	-	34	4350	c.4321C>A	c.(4321-4323)CAA>AAA	p.Q1441K	PZP_uc009zgl.2_Missense_Mutation_p.Q1227K	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						GGGATGTCTTGCAGAACCATG	0.403	Melanoma(125;1402 1695 4685 34487 38571)		NA											7	30					0.000274275	0.000298274	0.004482	1	0
DDX12	440081	broad.mit.edu	37	12	9583286	9583286	+	Silent	SNP	A	A	G	rs2429895	by1000genomes	TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr12:9583286A>G	uc010sgs.1	-	10	1335	c.1140T>C	c.(1138-1140)GCT>GCC	p.A380A		NM_004400	NP_004391			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12												0						GGATGCCCGCAGCCTGCCGAG	0.672			NA											3	14					0	0	0.001168	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398285	+	Missense_Mutation	DNP	CC	CC	AA	rs121913529		TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr12:25398284_25398285CC>AA	uc001rgp.1	-	2	215_216	c.34_35GG>TT	c.(34-36)GGT>TTT	p.G12F	KRAS_uc001rgq.1_Missense_Mutation_p.G12F|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAACT	0.347	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(CALU1_LUNG)|G12V(PATU8988S_PANCREAS)|G12C(NCIH1792_LUNG)|G12D(SU8686_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12D(LS513_LARGE_INTESTINE)|G12D(PANC0203_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12C(HCC44_LUNG)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEC50B_ENDOMETRIUM)|G12V(NCIH2444_LUNG)|G12D(MCAS_OVARY)|G12D(ASPC1_PANCREAS)|G12V(SHP77_LUNG)|G12R(CAL62_THYROID)|G12D(HPAFII_PANCREAS)|G12A(NCIH2009_LUNG)|G12D(PANC0403_PANCREAS)|G12C(NCIH2030_LUNG)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(PANC0327_PANCREAS)|G12D(PANC0813_PANCREAS)|G12V(COLO668_LUNG)|G12V(NCIH441_LUNG)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12V(CAPAN2_PANCREAS)|G12R(HUPT3_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12R(HS274T_BREAST)|G12V(SW480_LARGE_INTESTINE)|G12V(QGP1_PANCREAS)|G12S(LS123_LARGE_INTESTINE)|G12C(SW837_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(RKN_OVARY)|G12C(IALM_LUNG)|G12C(UMUC3_URINARY_TRACT)|G12V(RERFLCAD2_LUNG)|G12C(LU99_LUNG)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12V(SH10TC_STOMACH)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12D(COLO678_LARGE_INTESTINE)|G12S(A549_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(RERFLCAD1_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH1373_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12C(MIAPACA2_PANCREAS)|G12V(DANG_PANCREAS)|G12D(L33_PANCREAS)|G12C(OV56_OVARY)|G12V(PATU8902_PANCREAS)|G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12R(KP2_PANCREAS)|G12D(SUIT2_PANCREAS)|G12C(NCIH2122_LUNG)|G12D(KP4_PANCREAS)|G12C(NCIH358_LUNG)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12C(SW1463_LARGE_INTESTINE)|G12V(RCM1_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12D(PANC1_PANCREAS)|G12C(SW1573_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			12	20					0	0	0.004672	0	0
PTPRB	5787	broad.mit.edu	37	12	70946696	70946696	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr12:70946696T>C	uc001swb.3	-	19	4624	c.4594A>G	c.(4594-4596)AAA>GAA	p.K1532E	PTPRB_uc010sto.1_Missense_Mutation_p.K1442E|PTPRB_uc010stp.1_Missense_Mutation_p.K1442E|PTPRB_uc001swc.3_Missense_Mutation_p.K1750E|PTPRB_uc001swa.3_Missense_Mutation_p.K1662E	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1532	Fibronectin type-III 17.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TCGGCACATTTGCTGGCAAAA	0.473			NA											4	250					0	0	0.009096	0	0
IFT81	28981	broad.mit.edu	37	12	110570411	110570411	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr12:110570411A>G	uc001tqi.2	+	5	619	c.489A>G	c.(487-489)ATA>ATG	p.I163M	IFT81_uc001tqh.2_Missense_Mutation_p.I163M|IFT81_uc001tqj.2_RNA|IFT81_uc001tqg.2_Missense_Mutation_p.I163M	NM_001143779	NP_001137251	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81-like isoform 1	163	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				ovary(1)	1						AGCTCAAGATATCTGGATTTT	0.259			NA											9	14					0	0	0.008291	0	0
MED13L	23389	broad.mit.edu	37	12	116421330	116421330	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr12:116421330G>C	uc001tvw.2	-	21	4602	c.4547C>G	c.(4546-4548)ACT>AGT	p.T1516S		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1516					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		AAGCTGCAGAGTGGCTAAATA	0.473			NA									OREG0022156	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	45					0	0	0.013537	0	0
PCDH8	5100	broad.mit.edu	37	13	53418997	53418997	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr13:53418997C>A	uc001vhi.2	-	3	3114	c.2911G>T	c.(2911-2913)GGG>TGG	p.G971W	PCDH8_uc001vhj.2_Missense_Mutation_p.G874W	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	971	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		GCGTTGGGCCCGCTGCAGGAT	0.577	GBM(36;25 841 9273 49207)		NA											26	121					9.86323e-18	1.30015e-17	0.003954	1	0
NALCN	259232	broad.mit.edu	37	13	101712232	101712232	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr13:101712232C>T	uc001vox.1	-	42	5032	c.4843G>A	c.(4843-4845)GAG>AAG	p.E1615K		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1615	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGGGTGGTCTCGATGCTGGGC	0.572			NA											29	122					0	0	0.009535	0	0
TNFSF13B	10673	broad.mit.edu	37	13	108922448	108922448	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr13:108922448G>C	uc001vqr.2	+	1	472	c.205G>C	c.(205-207)GTG>CTG	p.V69L	TNFSF13B_uc010agj.2_Missense_Mutation_p.V69L	NM_006573	NP_006564	Q9Y275	TN13B_HUMAN	tumor necrosis factor superfamily, member 13b	69	Extracellular (Potential).				cell proliferation|immune response|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity|tumor necrosis factor receptor binding				0	all_lung(23;0.000396)|all_neural(89;0.00256)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00902)|Lung SC(71;0.104)		all cancers(43;0.184)|BRCA - Breast invasive adenocarcinoma(86;0.19)			TTTCTACCAGGTGGCCGCCCT	0.662			NA											79	192					0	0	0.01441	0	0
COL4A1	1282	broad.mit.edu	37	13	110827061	110827061	+	Silent	SNP	A	A	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr13:110827061A>T	uc001vqw.3	-	38	3356	c.3234T>A	c.(3232-3234)CCT>CCA	p.P1078P	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1078	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCTTCTCTCCAGGGCTTCCTG	0.517			NA											109	352					0	0	0.01441	0	0
OR4K1	79544	broad.mit.edu	37	14	20404500	20404500	+	Silent	SNP	C	C	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr14:20404500C>A	uc001vwj.1	+	1	675	c.675C>A	c.(673-675)GTC>GTA	p.V225V		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		TGATCGGTGTCCGATGCAGGT	0.418			NA											12	58					3.07112e-06	3.5625e-06	0.010729	1	0
ACIN1	22985	broad.mit.edu	37	14	23547389	23547389	+	Silent	SNP	C	C	G			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr14:23547389C>G	uc001wit.3	-	8	2596	c.2268G>C	c.(2266-2268)CTG>CTC	p.L756L	ACIN1_uc001wis.3_Silent_p.L438L|ACIN1_uc010akg.2_Silent_p.L756L	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	756					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		CTGATTCTGGCAGATGAGAGG	0.507			NA											53	140					0	0	0.01441	0	0
SPG11	80208	broad.mit.edu	37	15	44891010	44891010	+	Silent	SNP	G	G	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr15:44891010G>C	uc001ztx.2	-	22	3742	c.3711C>G	c.(3709-3711)GCC>GCG	p.A1237A	SPG11_uc010ueh.1_Silent_p.A1237A|SPG11_uc010uei.1_Silent_p.A1237A|SPG11_uc001zty.1_5'UTR	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1237	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CTATAACATAGGCTTCATTGC	0.408			NA											18	49					0	0	0.00499	0	0
LOC653786	653786	broad.mit.edu	37	16	22587979	22587979	+	Silent	SNP	T	T	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr16:22587979T>A	uc002dlh.3	+	9	2454	c.972T>A	c.(970-972)GTT>GTA	p.V324V		NR_003676				RecName: Full=Otoancorin; Flags: Precursor;												0						CCCTGCTGGTTCTAATGGCCA	0.527			NA											14	143					0	0	0.008871	0	0
BBS2	583	broad.mit.edu	37	16	56536674	56536674	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr16:56536674T>A	uc002ejd.2	-	8	1085	c.851A>T	c.(850-852)AAT>ATT	p.N284I	BBS2_uc010ccg.2_Missense_Mutation_p.N284I	NM_031885	NP_114091	Q9BXC9	BBS2_HUMAN	Bardet-Biedl syndrome 2 protein	284					adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			ovary(1)	1						AGAAGAAAAATTGTCCTTAAA	0.418			NA							Bardet-Biedl_syndrome				5	120					0	0	0.000602	0	0
FAM83G	644815	broad.mit.edu	37	17	18906919	18906919	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr17:18906919G>A	uc002guw.2	-	2	603	c.436C>T	c.(436-438)CGG>TGG	p.R146W	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	146										ovary(1)|central_nervous_system(1)	2						ACGCTAGCCCGGGTCACGCCG	0.677			NA											16	48					0	0	0.012319	0	0
Unknown	0	broad.mit.edu	37	17	21731313	21731313	+	Silent	SNP	G	G	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr17:21731313G>C	uc002gyy.3	+	2	740	c.615G>C	c.(613-615)GCG>GCC	p.A205A						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;												NA						GGAAGATGGCGGTACTCTTTC	0.517			NA											37	97					0	0	0.007835	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274150	39274150	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr17:39274150T>A	uc002hvz.2	-	1	457	c.418A>T	c.(418-420)AGC>TGC	p.S140C		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	140	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ctggagatgctgcagctgggg	0.129			NA											3	22					0	0	0.00245	0	0
HOXB1	3211	broad.mit.edu	37	17	46608145	46608146	+	Missense_Mutation	DNP	CT	CT	AA			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr17:46608145_46608146CT>AA	uc002ink.1	-	1	127_128	c.121_122AG>TT	c.(121-123)AGC>TTC	p.S41F		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	41						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCTTGCATAGCTGTCAACCGCC	0.663			NA											50	172					0	0	0.004672	0	0
TLK2	11011	broad.mit.edu	37	17	60637432	60637432	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr17:60637432A>T	uc010ddp.2	+	10	1044	c.776A>T	c.(775-777)TAC>TTC	p.Y259F	TLK2_uc002izx.3_Missense_Mutation_p.Y107F|TLK2_uc002izz.3_Missense_Mutation_p.Y259F|TLK2_uc002jaa.3_Missense_Mutation_p.Y227F|TLK2_uc010wpd.1_Missense_Mutation_p.Y227F	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	259	Potential.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						CTAGAGAAATACAAGGAACGA	0.348			NA											8	52					0	0	0.008291	0	0
ABCA8	10351	broad.mit.edu	37	17	66880001	66880001	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr17:66880001A>G	uc002jhp.2	-	27	3697	c.3518T>C	c.(3517-3519)TTT>TCT	p.F1173S	ABCA8_uc002jhq.2_Missense_Mutation_p.F1213S|ABCA8_uc010wqq.1_Missense_Mutation_p.F1213S	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	1173	Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					AGTAAAAAGAAAAATGATAAA	0.289			NA											3	8					0	0	0.004672	0	0
KCNJ2	3759	broad.mit.edu	37	17	68171422	68171422	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr17:68171422G>C	uc010dfg.2	+	2	643	c.242G>C	c.(241-243)TGG>TCG	p.W81S	KCNJ2_uc002jir.2_Missense_Mutation_p.W81S	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	81	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					GACATTCGCTGGCGGTGGATG	0.512			NA											3	156					0	0	0.004672	0	0
GRB2	2885	broad.mit.edu	37	17	73328799	73328799	+	Missense_Mutation	SNP	A	A	C	rs150762903		TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr17:73328799A>C	uc002jnx.3	-	3	515	c.158T>G	c.(157-159)ATA>AGA	p.I53R	GRB2_uc002jny.3_Missense_Mutation_p.I53R	NM_002086	NP_002077	P62993	GRB2_HUMAN	growth factor receptor-bound protein 2 isoform	53	SH3 1.				axon guidance|blood coagulation|cell junction assembly|cell-cell signaling|cellular response to ionizing radiation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|receptor internalization|signal transduction in response to DNA damage|T cell costimulation	cytosol|Golgi apparatus	epidermal growth factor receptor binding|insulin receptor substrate binding|SH3/SH2 adaptor activity			ovary(3)	3	all_cancers(13;5.44e-09)|all_epithelial(9;1.1e-09)|Breast(9;1.85e-09)|all_lung(278;0.222)		all cancers(21;1.09e-07)|Epithelial(20;1.23e-06)|Lung(188;0.185)		Pegademase bovine(DB00061)	TTTCATTTCTATGTAGTTCTT	0.398			NA											13	62					0	0	0.013537	0	0
FASN	2194	broad.mit.edu	37	17	80037127	80037127	+	Silent	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr17:80037127G>A	uc002kdu.2	-	43	7545	c.7428C>T	c.(7426-7428)GTC>GTT	p.V2476V	FASN_uc002kdv.1_RNA	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	2476	Thioesterase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	CACCCTCGATGACGTGGACGG	0.662	Colon(59;314 1043 11189 28578 32273)		NA											39	151					0	0	0.006999	0	0
DSG1	1828	broad.mit.edu	37	18	28908187	28908187	+	Silent	SNP	A	A	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr18:28908187A>T	uc002kwp.2	+	4	464	c.252A>T	c.(250-252)ACA>ACT	p.T84T		NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	84	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			AGCAAGTTACATACCGCATCT	0.373			NA											8	34					0	0	0.00308	0	0
ASXL3	80816	broad.mit.edu	37	18	31323436	31323436	+	Silent	SNP	T	T	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr18:31323436T>A	uc010dmg.1	+	12	3679	c.3624T>A	c.(3622-3624)CCT>CCA	p.P1208P	ASXL3_uc002kxq.2_Silent_p.P915P	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1208	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AAAACATACCTGTGTCACATT	0.398			NA											12	59					0	0	0.013537	0	0
BCL2	596	broad.mit.edu	37	18	60985890	60985890	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr18:60985890C>G	uc002lit.1	-	2	503	c.10G>C	c.(10-12)GCT>CCT	p.A4P	BCL2_uc002liu.1_Missense_Mutation_p.A4P|BCL2_uc002liv.1_Missense_Mutation_p.A4P	NM_000633	NP_000624	P10415	BCL2_HUMAN	B-cell lymphoma protein 2 alpha isoform	4					activation of pro-apoptotic gene products|anti-apoptosis|apoptosis in response to endoplasmic reticulum stress|B cell proliferation|B cell receptor signaling pathway|defense response to virus|female pregnancy|humoral immune response|induction of apoptosis by intracellular signals|negative regulation of cellular pH reduction|negative regulation of mitochondrial depolarization|negative regulation of neuron apoptosis|neuron apoptosis|positive regulation of B cell proliferation|positive regulation of cell growth|protein polyubiquitination|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|regulation of transmembrane transporter activity|release of cytochrome c from mitochondria|response to cytokine stimulus|response to DNA damage stimulus|response to drug|response to iron ion|response to nicotine|response to toxin	endoplasmic reticulum membrane|mitochondrial outer membrane|nuclear membrane|pore complex	BH3 domain binding|channel activity|protease binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)	1		all_hematologic(56;1.18e-20)|Prostate(75;0.0872)		Lung(128;0.0234)|READ - Rectum adenocarcinoma(59;0.0935)	Docetaxel(DB01248)|Fludarabine(DB01073)|Melatonin(DB01065)|Paclitaxel(DB01229)|Rasagiline(DB01367)	GTTCTCCCAGCGTGCGCCATC	0.557			NA	T	IGH@	NHL|CLL								25	124					0	0	0.005443	0	0
ZNF43	7594	broad.mit.edu	37	19	21991282	21991282	+	Silent	SNP	A	A	G			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr19:21991282A>G	uc002nqj.2	-	4	1687	c.1557T>C	c.(1555-1557)TTT>TTC	p.F519F	ZNF43_uc010ecv.2_Silent_p.F513F|ZNF43_uc002nql.2_Silent_p.F513F|ZNF43_uc002nqm.2_Silent_p.F513F|ZNF43_uc002nqk.2_Silent_p.F449F	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	519	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		AGGACCACTTAAAAGCTTTGC	0.368			NA											25	51					0	0	0.004656	0	0
RPSAP58	388524	broad.mit.edu	37	19	24010294	24010294	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr19:24010294C>G	uc002nrn.2	+	4	754	c.331C>G	c.(331-333)CAG>GAG	p.Q111E		NM_002295	NP_002286			ribosomal protein SA												0						CTTCACTAACCAGATCCAGGC	0.567			NA											4	52					0	0	0.000602	0	0
ZNF536	9745	broad.mit.edu	37	19	30935217	30935217	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr19:30935217G>T	uc002nsu.1	+	2	886	c.748G>T	c.(748-750)GAC>TAC	p.D250Y	ZNF536_uc010edd.1_Missense_Mutation_p.D250Y	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	250					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CAGCGTTCCCGACGTGGCCCA	0.746			NA											6	24					8.12818e-05	9.00831e-05	0.001984	1	0
ZNF536	9745	broad.mit.edu	37	19	31039011	31039011	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr19:31039011G>T	uc002nsu.1	+	4	2623	c.2485G>T	c.(2485-2487)GCT>TCT	p.A829S	ZNF536_uc010edd.1_Missense_Mutation_p.A829S	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	829					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GTCAAGCAAAGCTTCTCTGTT	0.577			NA											50	192					4.29476e-34	6.12531e-34	0.01441	1	0
ZNF829	374899	broad.mit.edu	37	19	37383369	37383369	+	Silent	SNP	C	C	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr19:37383369C>A	uc002ofa.1	-	6	686	c.324G>T	c.(322-324)CTG>CTT	p.L108L	ZNF345_uc002oez.2_Intron	NM_001037232	NP_001032309	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	108					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACATTGATTCCAGATCTGAAA	0.313			NA											5	38					3.59834e-05	4.03942e-05	0.001168	1	0
HNRNPL	3191	broad.mit.edu	37	19	39330766	39330766	+	Silent	SNP	A	A	G			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr19:39330766A>G	uc010xul.1	-	8	1214	c.1203T>C	c.(1201-1203)AAT>AAC	p.N401N	HNRNPL_uc010ege.1_Silent_p.N57N|HNRNPL_uc002ojj.1_Silent_p.N57N|HNRNPL_uc002ojo.1_5'Flank|HNRNPL_uc002ojk.2_Silent_p.N57N|HNRNPL_uc002ojl.2_Silent_p.N57N|HNRNPL_uc010xum.1_Silent_p.N268N|HNRNPL_uc002ojp.1_Silent_p.N57N|HNRNPL_uc010xun.1_3'UTR	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	401	RRM 3.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			AGCAGAAGACATTGAAGACTC	0.572			NA											44	156					0	0	0.01441	0	0
RELB	5971	broad.mit.edu	37	19	45515272	45515272	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr19:45515272G>C	uc002paj.1	+	5	368	c.242G>C	c.(241-243)CGC>CCC	p.R81P		NM_006509	NP_006500	Q01201	RELB_HUMAN	reticuloendotheliosis viral oncogene homolog B	81						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		GGGCTGCCACGCCTGGTGTCT	0.711			NA											5	13					0	0	0.001984	0	0
KLK3	354	broad.mit.edu	37	19	51359612	51359612	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr19:51359612G>A	uc002pts.1	+	2	204	c.163G>A	c.(163-165)GTG>ATG	p.V55M	KLK3_uc002ptp.1_Missense_Mutation_p.V55M|KLK3_uc010ycj.1_Missense_Mutation_p.V55M|KLK3_uc002ptr.1_Missense_Mutation_p.V55M|KLK3_uc010eof.1_RNA	NM_001030047	NP_001025218	P07288	KLK3_HUMAN	prostate specific antigen isoform 3	55	Peptidase S1.				negative regulation of angiogenesis|proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00763)|GBM - Glioblastoma multiforme(134;0.0144)		CGGTGTTCTGGTGCACCCCCA	0.632	Colon(185;1767 2023 13025 30120 37630)		NA											63	218					0	0	0.01441	0	0
LILRB1	10859	broad.mit.edu	37	19	55143640	55143640	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr19:55143640C>A	uc002qgj.2	+	6	953	c.613C>A	c.(613-615)CCC>ACC	p.P205T	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.P205T|LILRB1_uc002qgk.2_Missense_Mutation_p.P205T|LILRB1_uc002qgm.2_Missense_Mutation_p.P205T|LILRB1_uc010erq.2_Missense_Mutation_p.P205T|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	205	Ig-like C2-type 2.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CTCGAACTCTCCCTATGAGTG	0.607			NA								HNSCC(37;0.09)			51	203					5.82388e-19	7.79504e-19	0.01441	1	0
ZNF835	90485	broad.mit.edu	37	19	57175617	57175617	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr19:57175617T>C	uc010ygo.1	-	2	1016	c.1016A>G	c.(1015-1017)CAG>CGG	p.Q339R	ZNF835_uc010ygn.1_Missense_Mutation_p.Q317R	NM_001005850	NP_001005850			zinc finger protein 835									p.G334fs*26(1)		pancreas(3)|skin(1)	4						AGAGGCGCTCTGGCTGAAGAG	0.701			NA											6	19					0	0	0.00308	0	0
GALNT14	79623	broad.mit.edu	37	2	31178571	31178571	+	Silent	SNP	G	G	T	rs145356432		TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr2:31178571G>T	uc002rnr.2	-	6	1186	c.567C>A	c.(565-567)ATC>ATA	p.I189I	GALNT14_uc002rnq.2_Silent_p.I169I|GALNT14_uc002rns.2_Silent_p.I194I|GALNT14_uc010ymr.1_Silent_p.I154I|GALNT14_uc010ezo.1_Silent_p.I156I|GALNT14_uc010ezp.1_Silent_p.I160I	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	189	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					TGCCCTGGGCGATGTCAGCGC	0.602			NA											33	134					6.00712e-18	7.97893e-18	0.012213	1	0
ORC2L	4999	broad.mit.edu	37	2	201814323	201814323	+	Silent	SNP	A	A	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr2:201814323A>C	uc002uwr.2	-	5	539	c.282T>G	c.(280-282)GTT>GTG	p.V94V	ORC2L_uc010zhj.1_Silent_p.V94V	NM_006190	NP_006181	Q13416	ORC2_HUMAN	origin recognition complex, subunit 2	94					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0						GAAAAGAATAAACTTTATTTC	0.284			NA											8	37					0	0	0.008291	0	0
WDR69	164781	broad.mit.edu	37	2	228750068	228750068	+	Silent	SNP	A	A	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr2:228750068A>T	uc002vpn.1	+	2	121	c.42A>T	c.(40-42)GGA>GGT	p.G14G	WDR69_uc010zlw.1_5'UTR|WDR69_uc002vpo.1_RNA	NM_178821	NP_849143	Q8N136	WDR69_HUMAN	WD repeat domain 69	14										breast(1)	1		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;1.22e-10)|all cancers(144;8.11e-08)|Lung(261;0.011)|LUSC - Lung squamous cell carcinoma(224;0.0148)		TTTCTATAGGAATTATGTTGG	0.303			NA											12	38					0	0	0.001855	0	0
NGEF	25791	broad.mit.edu	37	2	233839373	233839373	+	Silent	SNP	C	C	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr2:233839373C>T	uc002vts.2	-	2	476	c.228G>A	c.(226-228)AAG>AAA	p.K76K		NM_019850	NP_062824	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	76	Regulatory region; modulates activity toward RHOA, RAC1 and CDC42 (By similarity).				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)|skin(1)	7		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		TGTCTCTGGCCTTGGCTTTGC	0.512			NA											86	369					0	0	0.01441	0	0
PER2	8864	broad.mit.edu	37	2	239186473	239186473	+	Silent	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr2:239186473G>A	uc002vyc.2	-	2	342	c.105C>T	c.(103-105)AGC>AGT	p.S35S	PER2_uc010znv.1_Silent_p.S35S|PER2_uc010znw.1_Silent_p.S35S|PER2_uc010fyx.1_Silent_p.S35S	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	35					circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		TGGAGCCACTGCTCATGTCCA	0.627			NA											27	138					0	0	0.004289	0	0
SIRPG	55423	broad.mit.edu	37	20	1629958	1629958	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr20:1629958G>A	uc002wfm.1	-	2	235	c.170C>T	c.(169-171)TCC>TTC	p.S57F	SIRPG_uc002wfn.1_Missense_Mutation_p.S57F|SIRPG_uc002wfo.1_Missense_Mutation_p.S57F	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	57	Extracellular (Potential).|Ig-like V-type.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						GGGAAGCAGGGAGGTCACAGT	0.537			NA											23	126					0	0	0.012319	0	0
PTPRA	5786	broad.mit.edu	37	20	3002719	3002719	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr20:3002719G>T	uc010zqd.1	+	14	1531	c.1214G>T	c.(1213-1215)AGA>ATA	p.R405I	PTPRA_uc002whj.2_Missense_Mutation_p.R394I|PTPRA_uc002whk.2_Missense_Mutation_p.R385I|PTPRA_uc002whl.2_Missense_Mutation_p.R385I|PTPRA_uc002whm.2_Missense_Mutation_p.R161I|PTPRA_uc002whn.2_Missense_Mutation_p.R385I|PTPRA_uc002who.2_Missense_Mutation_p.R57I	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	394	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1						ATGACCAACAGAAAGCCACAG	0.567			NA											7	138					8.12818e-05	9.00831e-05	0.001984	1	0
CHD6	84181	broad.mit.edu	37	20	40054003	40054003	+	Silent	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr20:40054003G>T	uc002xka.1	-	29	4339	c.4161C>A	c.(4159-4161)CCC>CCA	p.P1387P		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1387					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				AAACTGGCCAGGGCGATTTGT	0.512			NA											14	36					4.7546e-09	5.78532e-09	0.004007	1	0
TMEM189-UBE2V1	387522	broad.mit.edu	37	20	48700726	48700726	+	Silent	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr20:48700726G>A	uc002xvf.2	-	7	1067	c.906C>T	c.(904-906)CCC>CCT	p.P302P	UBE2V1_uc002xvb.2_RNA|UBE2V1_uc002xva.2_Silent_p.P79P|UBE2V1_uc002xvc.2_Silent_p.P35P|UBE2V1_uc002xvd.2_Silent_p.P102P|UBE2V1_uc002xve.2_Silent_p.P102P	NM_199203	NP_954673	Q13404	UB2V1_HUMAN	TMEM189-UBE2V1 readthrough transcript	79					cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein K63-linked ubiquitination|regulation of DNA repair|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus|UBC13-UEV1A complex|ubiquitin ligase complex	acid-amino acid ligase activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(9;8.29e-07)			TTACAAAGGGGGGTGCTTCTG	0.358			NA											47	117					0	0	0.01441	0	0
LAMA5	3911	broad.mit.edu	37	20	60897373	60897373	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr20:60897373G>A	uc002ycq.2	-	47	6365	c.6298C>T	c.(6298-6300)CGC>TGC	p.R2100C		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2100	Laminin EGF-like 21.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCACACTCGCGGCACTGGGGT	0.711			NA											3	25					0	0	0.000602	0	0
DSCAM	1826	broad.mit.edu	37	21	41465695	41465695	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr21:41465695C>T	uc002yyq.1	-	21	4255	c.3803G>A	c.(3802-3804)GGA>GAA	p.G1268E	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1268	Fibronectin type-III 4.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GTTGCCTCTTCCGGCTGAAGT	0.488	Melanoma(134;970 1778 1785 21664 32388)		NA											11	30					0	0	0.008291	0	0
KRTAP10-9	386676	broad.mit.edu	37	21	46047658	46047658	+	Silent	SNP	T	T	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr21:46047658T>A	uc002zfp.3	+	1	619	c.570T>A	c.(568-570)CCT>CCA	p.P190P	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198690	NP_941963	P60411	KR109_HUMAN	keratin associated protein 10-9	190	18.|25 X 5 AA repeats of C-C-X(3).					keratin filament					0						GCTGTAAGCCTGTCTGCTGCA	0.592			NA											178	687					0	0	0.01441	0	0
APOBEC3G	60489	broad.mit.edu	37	22	39479863	39479863	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr22:39479863C>A	uc003awx.2	+	5	1051	c.709C>A	c.(709-711)CAG>AAG	p.Q237K	APOBEC3G_uc003awy.2_Missense_Mutation_p.Q170K	NM_021822	NP_068594	Q9HC16	ABC3G_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	237					base conversion or substitution editing|DNA cytosine deamination|innate immune response|interspecies interaction between organisms|negative regulation of retroviral genome replication|negative regulation of transposition|positive regulation of defense response to virus by host|response to virus|viral reproduction	apolipoprotein B mRNA editing enzyme complex|cytosol|mitochondrion	cytidine deaminase activity|dCTP deaminase activity|protein homodimerization activity|RNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2	Melanoma(58;0.04)					CCTGCTGAACCAGCGCAGGGG	0.572			NA											31	114					4.31634e-10	5.32654e-10	0.012213	1	0
SULT4A1	25830	broad.mit.edu	37	22	44221917	44221917	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr22:44221917C>T	uc003bee.1	-	7	935	c.819G>A	c.(817-819)ATG>ATA	p.M273I	SULT4A1_uc003bed.1_Missense_Mutation_p.M194I|SULT4A1_uc003bef.1_RNA|SULT4A1_uc011aqb.1_Missense_Mutation_p.M160I	NM_014351	NP_055166	Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	273					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity				0		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		CACACTTTCCCATCTTCTGTT	0.418			NA											31	168					0	0	0.010818	0	0
EFHB	151651	broad.mit.edu	37	3	19961381	19961381	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr3:19961381C>A	uc003cbl.3	-	3	1136	c.940G>T	c.(940-942)GAT>TAT	p.D314Y	EFHB_uc003cbm.2_Missense_Mutation_p.D184Y	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	314					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						ATCTGGGGATCATTTGCTCTT	0.333			NA											14	77					0.00121646	0.00130657	0.008871	1	0
EXOG	9941	broad.mit.edu	37	3	38565414	38565414	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr3:38565414C>T	uc003cih.2	+	6	764	c.668C>T	c.(667-669)GCA>GTA	p.A223V	EXOG_uc010hhg.2_RNA|EXOG_uc011ayq.1_Missense_Mutation_p.A173V|EXOG_uc003cij.2_Missense_Mutation_p.A83V|EXOG_uc010hhd.2_Missense_Mutation_p.A83V|EXOG_uc010hhe.2_Missense_Mutation_p.A83V|EXOG_uc003cik.2_Missense_Mutation_p.A83V|EXOG_uc010hhf.2_Missense_Mutation_p.A83V|EXOG_uc003cii.2_Missense_Mutation_p.A83V	NM_005107	NP_005098	Q9Y2C4	EXOG_HUMAN	endo/exonuclease (5'-3'), endonuclease G-like	223						mitochondrial inner membrane	endonuclease activity|metal ion binding|nucleic acid binding				0						GACAACGTGGCAGTCCCCTCA	0.453			NA											20	82					0	0	0.008871	0	0
TRAK1	22906	broad.mit.edu	37	3	42244104	42244104	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr3:42244104G>T	uc003cky.2	+	13	1820	c.1604G>T	c.(1603-1605)AGC>ATC	p.S535I	TRAK1_uc011azh.1_Missense_Mutation_p.S535I|TRAK1_uc011azi.1_Missense_Mutation_p.S535I|TRAK1_uc003ckz.3_Missense_Mutation_p.S461I|TRAK1_uc011azj.1_Missense_Mutation_p.S461I|TRAK1_uc003cla.2_Missense_Mutation_p.S477I	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	535					endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						GAGCTGCGCAGCGGCTCCCTC	0.637	GBM(44;195 884 22595 31865 41850)		NA											18	103					9.95505e-16	1.2831e-15	0.014323	1	0
NME6	10201	broad.mit.edu	37	3	48339978	48339978	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr3:48339978G>T	uc003csp.3	-	2	80	c.29C>A	c.(28-30)GCT>GAT	p.A10D	NME6_uc003cso.2_Missense_Mutation_p.A18D|NME6_uc011bbh.1_Missense_Mutation_p.A10D|NME6_uc010hju.2_Intron|NME6_uc011bbi.1_Missense_Mutation_p.A10D	NM_005793	NP_005784	O75414	NDK6_HUMAN	nucleoside diphosphate kinase type 6	10					anti-apoptosis|apoptosis|CTP biosynthetic process|GTP biosynthetic process|negative regulation of cell growth|negative regulation of mitosis|UTP biosynthetic process	mitochondrion	ATP binding|metal ion binding|nucleoside diphosphate kinase activity				0				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00609)		GAGCTGGAGAGCCTGAGGGCT	0.547			NA											3	43					0.004672	0.00495688	0.004672	1	0
CACNA1D	776	broad.mit.edu	37	3	53810712	53810712	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr3:53810712T>C	uc003dgv.3	+	36	4608	c.4445T>C	c.(4444-4446)TTA>TCA	p.L1482S	CACNA1D_uc003dgu.3_Missense_Mutation_p.L1502S|CACNA1D_uc003dgy.3_Missense_Mutation_p.L1467S|CACNA1D_uc003dgw.3_Missense_Mutation_p.L1149S|CACNA1D_uc003dgx.1_Missense_Mutation_p.L658S	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1482	Dihydropyridine binding (By similarity).|Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CCTCACCATTTAGATGAATTC	0.403			NA											43	166					0	0	0.00874	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54919343	54919343	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr3:54919343G>T	uc003dhf.2	+	22	1996	c.1948G>T	c.(1948-1950)GCA>TCA	p.A650S	CACNA2D3_uc011beu.1_RNA|CACNA2D3_uc003dhg.1_Missense_Mutation_p.A556S|CACNA2D3_uc003dhh.1_RNA|CACNA2D3_uc010hmv.1_Missense_Mutation_p.A384S|uc003dhk.1_Intron	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	650	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TGTGTCCTTGGCAGATGAATG	0.493			NA											17	83					1.87028e-06	2.19884e-06	0.012319	1	0
ROBO2	6092	broad.mit.edu	37	3	77147419	77147419	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr3:77147419G>A	uc003dpy.3	+	2	959	c.316G>A	c.(316-318)GGA>AGA	p.G106R	ROBO2_uc003dpz.2_Missense_Mutation_p.G106R|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.G106R	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	106	Ig-like C2-type 1.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		ACCTGATGAAGGAAGCTACGT	0.517			NA											27	92					0	0	0.003954	0	0
CASR	846	broad.mit.edu	37	3	122003109	122003109	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr3:122003109C>A	uc003eev.3	+	7	2680	c.2308C>A	c.(2308-2310)CTC>ATC	p.L770I	CASR_uc003eew.3_Missense_Mutation_p.L780I	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	770	Helical; Name=5; (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CGAGGGCTCCCTCATGGCCCT	0.582			NA											20	82					2.21704e-12	2.75546e-12	0.00278	1	0
ALDH1L1	10840	broad.mit.edu	37	3	125877379	125877379	+	Silent	SNP	C	C	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr3:125877379C>A	uc003eim.1	-	3	421	c.231G>T	c.(229-231)GGG>GGT	p.G77G	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Silent_p.G77G|ALDH1L1_uc003eio.2_5'Flank|ALDH1L1_uc010hsf.1_Silent_p.G103G|ALDH1L1_uc003eip.1_5'UTR|ALDH1L1_uc011bkj.1_Intron	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	77	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	TGAGCTCGGCCCCCAAAGCCT	0.567			NA											33	142					9.21846e-06	1.06226e-05	0.013726	1	0
MME	4311	broad.mit.edu	37	3	154858045	154858045	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr3:154858045G>T	uc010hvr.1	+	10	1132	c.921G>T	c.(919-921)CAG>CAT	p.Q307H	MME_uc003fab.1_Missense_Mutation_p.Q307H|MME_uc003fac.1_Missense_Mutation_p.Q307H|MME_uc003fad.1_Missense_Mutation_p.Q307H|MME_uc003fae.1_Missense_Mutation_p.Q307H	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	307	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CATTGGCCCAGATCCAAAATA	0.323			NA											3	18					1.024e-07	1.23733e-07	0.000602	1	0
SDHAP2	727956	broad.mit.edu	37	3	195410689	195410689	+	Missense_Mutation	SNP	C	C	T	rs6583275	by1000genomes	TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr3:195410689C>T	uc003fuw.2	+	13	1780	c.586C>T	c.(586-588)CAC>TAC	p.H196Y	SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						CTTTGAGGTGCACTGGAGGAA	0.567			NA											4	35					0	0	0.001168	0	0
KIAA0232	9778	broad.mit.edu	37	4	6865249	6865249	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr4:6865249C>G	uc003gjr.3	+	7	3603	c.3140C>G	c.(3139-3141)CCA>CGA	p.P1047R	KIAA0232_uc003gjq.3_Missense_Mutation_p.P1047R	NM_014743	NP_055558	Q92628	K0232_HUMAN	hypothetical protein LOC9778	1047							ATP binding			ovary(2)	2						TTAAGCAATCCATTTTCACAA	0.383			NA											23	70					0	0	0.00278	0	0
PDS5A	23244	broad.mit.edu	37	4	39868522	39868522	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr4:39868522C>T	uc003guv.3	-	23	3141	c.2601G>A	c.(2599-2601)ATG>ATA	p.M867I	PDS5A_uc010ifo.2_Missense_Mutation_p.M827I	NM_001100399	NP_001093869	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog	867					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0						CACTAACCAACATCGCTGATA	0.393			NA											7	37					0	0	0.001984	0	0
RASL11B	65997	broad.mit.edu	37	4	53731759	53731759	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr4:53731759C>A	uc003gzt.2	+	4	714	c.534C>A	c.(532-534)TTC>TTA	p.F178L		NM_023940	NP_076429	Q9BPW5	RSLBB_HUMAN	RAS-like family 11 member B	178	Small GTPase-like.				small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(32;0.0302)			GCTGCTCATTCTATGAAGTGT	0.507			NA											109	419					6.64951e-56	9.56211e-56	0.01441	1	0
UGT2B7	7364	broad.mit.edu	37	4	69962330	69962330	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr4:69962330C>T	uc003heg.3	+	1	138	c.92C>T	c.(91-93)GCA>GTA	p.A31V	UGT2B7_uc010ihq.2_Missense_Mutation_p.A31V	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	31					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						GTGTGGGCAGCAGAATACAGC	0.428			NA											15	56					0	0	0.004007	0	0
NPFFR2	10886	broad.mit.edu	37	4	72994591	72994591	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr4:72994591G>A	uc003hgg.2	+	2	687	c.589G>A	c.(589-591)GGC>AGC	p.G197S	NPFFR2_uc010iig.1_Intron|NPFFR2_uc003hgi.2_Missense_Mutation_p.G98S|NPFFR2_uc003hgh.2_Missense_Mutation_p.G95S	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	197	Helical; Name=2; (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TTTACTAGTTGGCATATTCTG	0.358			NA											29	121					0	0	0.012213	0	0
STBD1	8987	broad.mit.edu	37	4	77230372	77230372	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr4:77230372G>T	uc003hka.2	+	2	542	c.296G>T	c.(295-297)AGA>ATA	p.R99I	STBD1_uc003hjy.2_3'UTR|STBD1_uc011cbv.1_3'UTR|STBD1_uc011cbw.1_5'UTR	NM_003943	NP_003934	O95210	STBD1_HUMAN	starch binding domain 1	99	Cytoplasmic (Potential).				carbohydrate metabolic process|muscle contraction	integral to plasma membrane|membrane fraction	carbohydrate binding|catalytic activity|protein binding			ovary(1)	1			Lung(101;0.196)			GCATCATGGAGATTGCAGAAT	0.418			NA											30	85					1.75199e-13	2.20902e-13	0.007291	1	0
PPM1K	152926	broad.mit.edu	37	4	89183867	89183867	+	Nonsense_Mutation	SNP	G	G	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr4:89183867G>C	uc003hrm.3	-	7	1389	c.999C>G	c.(997-999)TAC>TAG	p.Y333*		NM_152542	NP_689755	Q8N3J5	PPM1K_HUMAN	protein phosphatase 1K (PP2C domain containing)	333	PP2C-like.				protein dephosphorylation	mitochondrial matrix|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000192)		CCTCAGTACCGTACTGTATTG	0.418			NA											12	42					0	0	0.00245	0	0
RASGRF2	5924	broad.mit.edu	37	5	80388726	80388726	+	Silent	SNP	A	A	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr5:80388726A>C	uc003kha.1	+	10	1497	c.1497A>C	c.(1495-1497)ACA>ACC	p.T499T	RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	499	PH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TCTTATTTACAAAACACTTTT	0.388			NA											20	62					0	0	0.008871	0	0
GPR98	84059	broad.mit.edu	37	5	89931018	89931018	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr5:89931018G>A	uc003kju.2	+	10	2023	c.1927G>A	c.(1927-1929)GTT>ATT	p.V643I	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	643	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTCTTTACTGGTTACTCCAGC	0.378			NA											13	40					0	0	0.013537	0	0
PCDHA13	56136	broad.mit.edu	37	5	140261961	140261961	+	Silent	SNP	C	C	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr5:140261961C>T	uc003lif.2	+	1	108	c.108C>T	c.(106-108)CCC>CCT	p.P36P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.P36P|PCDHA13_uc003lid.2_Silent_p.P36P	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	36	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTCCGTCCCCGAGGAAGCAA	0.657	Melanoma(147;1739 1852 5500 27947 37288)		NA											103	314					0	0	0.01441	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34802159	34802159	+	Silent	SNP	C	C	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr6:34802159C>T	uc003oju.3	+	5	738	c.504C>T	c.(502-504)CGC>CGT	p.R168R	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	168										ovary(3)	3						GCCTTACCCGCATCACTGACC	0.502			NA											29	79					0	0	0.010818	0	0
SLC26A8	116369	broad.mit.edu	37	6	35922941	35922941	+	Silent	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr6:35922941G>T	uc003olm.2	-	17	2331	c.2220C>A	c.(2218-2220)GTC>GTA	p.V740V	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Silent_p.V322V|SLC26A8_uc003oln.2_Silent_p.V740V|SLC26A8_uc003oll.2_Silent_p.V635V	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	740	Interaction with RACGAP1.|STAS.|Cytoplasmic (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						GTCTTAATACGACTAACCCCC	0.512			NA											45	228					9.9998e-32	1.41461e-31	0.011902	1	0
FAM83B	222584	broad.mit.edu	37	6	54805391	54805391	+	Missense_Mutation	SNP	G	G	T	rs146327371		TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr6:54805391G>T	uc003pck.2	+	5	1738	c.1622G>T	c.(1621-1623)CGT>CTT	p.R541L		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	541				R -> S (in Ref. 4; BAB70873).						ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					TCTCGGCTTCGTTCCTCTTTA	0.418			NA											8	44					7.48243e-07	8.91742e-07	0.006214	1	0
ME1	4199	broad.mit.edu	37	6	84025069	84025069	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr6:84025069C>T	uc003pjy.2	-	6	770	c.664G>A	c.(664-666)GAT>AAT	p.D222N	ME1_uc011dzb.1_Missense_Mutation_p.D147N|ME1_uc011dzc.1_Missense_Mutation_p.D56N	NM_002395	NP_002386	P48163	MAOX_HUMAN	cytosolic malic enzyme 1	222					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	AAAAAATCATCATATTCAGAA	0.299			NA											5	27					0	0	0.00308	0	0
TBX18	9096	broad.mit.edu	37	6	85473649	85473649	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr6:85473649C>A	uc003pkl.1	-	1	251	c.251G>T	c.(250-252)GGG>GTG	p.G84V	TBX18_uc010kbq.1_5'Flank	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	84					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		CCGAGCCGGCCCAGACGTCGC	0.557			NA											3	7					3.59834e-05	4.03942e-05	0.001168	1	0
MOXD1	26002	broad.mit.edu	37	6	132641792	132641792	+	Silent	SNP	C	C	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr6:132641792C>T	uc003qdf.2	-	9	1440	c.1341G>A	c.(1339-1341)ACG>ACA	p.T447T	MOXD1_uc003qde.2_Silent_p.T379T	NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1 isoform 2	447	Lumenal (Potential).				catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			ovary(1)	1	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		CTCTATCTTTCGTGTTGTAGC	0.299			NA											3	20					0	0	0.009096	0	0
UNC93A	54346	broad.mit.edu	37	6	167717596	167717596	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr6:167717596G>T	uc003qvq.2	+	5	990	c.815G>T	c.(814-816)GGA>GTA	p.G272V	UNC93A_uc003qvr.2_Missense_Mutation_p.G230V	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	272	Helical; (Potential).					integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		TTGCAGCAAGGATTCCTCTCC	0.368			NA											54	222					1.44317e-28	2.00889e-28	0.01441	1	0
PDE1C	5137	broad.mit.edu	37	7	31876897	31876897	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr7:31876897G>T	uc003tcm.1	-	11	1569	c.1100C>A	c.(1099-1101)GCC>GAC	p.A367D	PDE1C_uc003tcn.1_Missense_Mutation_p.A367D|PDE1C_uc003tco.1_Missense_Mutation_p.A427D|PDE1C_uc003tcr.2_Missense_Mutation_p.A367D|PDE1C_uc003tcs.2_Missense_Mutation_p.A367D	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	367	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			AAGGGATAAGGCTTTTGGCTT	0.408			NA											9	33					9.70103e-10	1.18872e-09	0.008291	1	0
TYW1B	441250	broad.mit.edu	37	7	72178676	72178676	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr7:72178676T>C	uc011kej.1	-	13	1432	c.1273A>G	c.(1273-1275)ATA>GTA	p.I425V	TYW1B_uc011keh.1_Missense_Mutation_p.I263V|TYW1B_uc011kei.1_Missense_Mutation_p.I51V	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	425					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						GGGTACATTATTGGTTCTCCC	0.473			NA											16	32					0	0	0.008871	0	0
CSMD1	64478	broad.mit.edu	37	8	2975964	2975964	+	Silent	SNP	A	A	G			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr8:2975964A>G	uc011kwk.1	-	42	6780	c.6390T>C	c.(6388-6390)CAT>CAC	p.H2130H	CSMD1_uc011kwj.1_Silent_p.H1522H|CSMD1_uc010lrg.2_Silent_p.H198H	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2130	Extracellular (Potential).|Sushi 12.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGTTGATCCCATGCTGACAAG	0.443			NA											19	75					0	0	0.006122	0	0
ENTPD4	9583	broad.mit.edu	37	8	23305214	23305214	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr8:23305214C>A	uc003xdl.2	-	4	555	c.391G>T	c.(391-393)GTG>TTG	p.V131L	ENTPD4_uc011kzu.1_Missense_Mutation_p.V131L|ENTPD4_uc003xdm.2_Missense_Mutation_p.V131L|ENTPD4_uc011kzv.1_Missense_Mutation_p.V131L|ENTPD4_uc011kzw.1_Missense_Mutation_p.V97L	NM_004901	NP_004892	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	131	Lumenal (Potential).				UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			ovary(1)|kidney(1)	2		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		TTCATGACCACTGGCTTTCGG	0.448			NA											33	165					2.42023e-17	3.16632e-17	0.003271	1	0
ANK1	286	broad.mit.edu	37	8	41554286	41554286	+	Silent	SNP	A	A	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr8:41554286A>T	uc003xok.2	-	25	2727	c.2643T>A	c.(2641-2643)TCT>TCA	p.S881S	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Silent_p.S197S|ANK1_uc003xoi.2_Silent_p.S881S|ANK1_uc003xoj.2_Silent_p.S881S|ANK1_uc003xol.2_Silent_p.S881S|ANK1_uc003xom.2_Silent_p.S922S	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	881					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CATACTCTTTAGATGCCTGAG	0.632			NA											18	61					0	0	0.007413	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885786	88885786	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr8:88885786C>A	uc003ydz.2	-	1	511	c.414G>T	c.(412-414)TTG>TTT	p.L138F		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	138										ovary(1)	1						GGTGGGAATCCAAGTGATTCA	0.562			NA											46	170					6.68952e-21	9.16517e-21	0.013114	1	0
ADCY8	114	broad.mit.edu	37	8	131792844	131792844	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr8:131792844G>A	uc003ytd.3	-	18	3804	c.3548C>T	c.(3547-3549)CCA>CTA	p.P1183L	ADCY8_uc010mds.2_Missense_Mutation_p.P1052L	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	1183	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CAGTCTTCTTGGGGGCAAGAT	0.512			NA								HNSCC(32;0.087)			38	137					0	0	0.004289	0	0
GALT	2592	broad.mit.edu	37	9	34648858	34648858	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr9:34648858C>T	uc003zve.2	+	8	854	c.787C>T	c.(787-789)CGG>TGG	p.R263W	GALT_uc003zvf.2_Missense_Mutation_p.R154W|GALT_uc003zvg.2_Missense_Mutation_p.R135W|GALT_uc003zvh.2_Missense_Mutation_p.R215W|GALT_uc011lop.1_Missense_Mutation_p.R215W|IL11RA_uc003zvi.2_5'Flank	NM_000155	NP_000146	P07902	GALT_HUMAN	galactose-1-phosphate uridylyltransferase	263			Missing (in GALCT).		galactose catabolic process	cytosol	UDP-glucose:hexose-1-phosphate uridylyltransferase activity|zinc ion binding				0	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.173)		GCATGTGCGGCGGCTACCTGA	0.607			NA							Galactosemia				7	108					0	0	0.001984	0	0
CTSL3	392360	broad.mit.edu	37	9	90388511	90388511	+	Missense_Mutation	SNP	C	C	T	rs138191329	byFrequency	TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr9:90388511C>T	uc004apm.1	+	3	377	c.371C>T	c.(370-372)CCG>CTG	p.P124L		NR_027917				RecName: Full=Putative cathepsin L-like protein 3;          Short=Cathepsin L-like protein; AltName: Full=HCTSL-s;											ovary(1)	1						AGTATGTTGCCGACAATGGAG	0.458			NA											33	57					0	0	0.013726	0	0
SCAI	286205	broad.mit.edu	37	9	127818229	127818229	+	Silent	SNP	T	T	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr9:127818229T>A	uc004bpe.2	-	3	237	c.156A>T	c.(154-156)CCA>CCT	p.P52P	SCAI_uc004bpd.2_Silent_p.P75P|SCAI_uc010mwu.2_RNA	NM_001144877	NP_001138349	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion isoform 2	52	Necessary to inhibit MKL1-induced SRF transcriptional activity (By similarity).				negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			ovary(2)|breast(2)|central_nervous_system(1)	5						TCTCTCCCTGTGGGATATCAT	0.378			NA											16	28					0	0	0.004007	0	0
KCNT1	57582	broad.mit.edu	37	9	138675891	138675891	+	Missense_Mutation	SNP	A	A	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr9:138675891A>C	uc011mdq.1	+	25	2937	c.2863A>C	c.(2863-2865)AAC>CAC	p.N955H	KCNT1_uc011mdr.1_Missense_Mutation_p.N782H|KCNT1_uc010nbf.2_Missense_Mutation_p.N910H|KCNT1_uc004cgo.1_Missense_Mutation_p.N704H	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	955						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		GAATGGCTCCAACCTGGCCTT	0.662			NA											5	112					0	0	0.001984	0	0
NOTCH1	4851	broad.mit.edu	37	9	139407481	139407481	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr9:139407481G>A	uc004chz.2	-	15	2459	c.2459C>T	c.(2458-2460)CCC>CTC	p.P820L	NOTCH1_uc004cia.1_Missense_Mutation_p.P50L	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	820	Extracellular (Potential).|EGF-like 21; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ACCTGTGTAGGGCAGCAGGCA	0.637			NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			38	74					0	0	0.00623	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29973554	29973554	+	Nonsense_Mutation	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chrX:29973554G>T	uc004dby.2	+	11	2216	c.1708G>T	c.(1708-1710)GAG>TAG	p.E570*		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	570	Cytoplasmic (Potential).|Interaction with NCS1.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						CATTACACATGAGCAGGCTTT	0.488			NA											15	52					6.81908e-15	8.72441e-15	0.00245	1	0
ITIH5L	347365	broad.mit.edu	37	X	54784148	54784148	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chrX:54784148C>A	uc004dtj.2	-	8	2389	c.2359G>T	c.(2359-2361)GGT>TGT	p.G787C		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	787	Pro-rich.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						GATGGAGCACCAGGTTTGGAA	0.547			NA											58	195					7.10663e-31	9.9722e-31	0.01441	1	0
ZCCHC13	389874	broad.mit.edu	37	X	73524453	73524453	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chrX:73524453C>A	uc004ebs.3	+	1	429	c.352C>A	c.(352-354)CTT>ATT	p.L118I		NM_203303	NP_976048	Q8WW36	ZCH13_HUMAN	zinc finger, CCHC domain containing 13	118	CCHC-type 5.						nucleic acid binding|zinc ion binding				0						TTGCGGCAAACTTGGGCACAT	0.542			NA											39	100					1.60099e-16	2.07889e-16	0.004878	1	0
PCDH19	57526	broad.mit.edu	37	X	99663203	99663203	+	Silent	SNP	T	T	A			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chrX:99663203T>A	uc010nmz.2	-	1	2069	c.393A>T	c.(391-393)GCA>GCT	p.A131A	PCDH19_uc004efw.3_Silent_p.A131A|PCDH19_uc004efx.3_Silent_p.A131A	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	131	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						CGATCTGTGCTGCCGGGAAAC	0.577			NA											74	333					0	0	0.01441	0	0
COL4A6	1288	broad.mit.edu	37	X	107408255	107408255	+	Silent	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chrX:107408255G>T	uc004enw.3	-	39	3928	c.3825C>A	c.(3823-3825)CCC>CCA	p.P1275P	COL4A6_uc004env.3_Silent_p.P1274P|COL4A6_uc011msn.1_Silent_p.P1250P|COL4A6_uc010npk.2_Silent_p.P1250P|COL4A6_uc010npj.2_5'Flank	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	1275	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						GGGGTCCAGCGGGGCCTGGGC	0.632	Melanoma(87;1895 1945 2589 7165)		NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				18	111					8.81451e-21	1.19822e-20	0.008871	1	0
CT47B1	643311	broad.mit.edu	37	X	120008919	120008919	+	Silent	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chrX:120008919G>T	uc011muc.1	-	1	861	c.606C>A	c.(604-606)GTC>GTA	p.V202V		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	202											0						CAGGCTCTGGGACCGACGCGG	0.627			NA											48	175					5.57489e-27	7.69866e-27	0.01441	1	0
ACTRT1	139741	broad.mit.edu	37	X	127185520	127185520	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chrX:127185520G>C	uc004eum.2	-	1	863	c.666C>G	c.(664-666)ATC>ATG	p.I222M		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	222						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						GCTCCAAGGCGATGTAGCACA	0.527			NA											48	219					0	0	0.01441	0	0
BCORL1	63035	broad.mit.edu	37	X	129154963	129154963	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chrX:129154963C>T	uc004evb.1	+	5	3559	c.3445C>T	c.(3445-3447)CGG>TGG	p.R1149W	BCORL1_uc010nrd.1_Missense_Mutation_p.R1051W	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	1149					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						TCCACAGTGCCGGAAGCTGCC	0.547			NA											15	110					0	0	0.00499	0	0
F8	2157	broad.mit.edu	37	X	154157209	154157209	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chrX:154157209G>T	uc004fmt.2	-	14	5027	c.4856C>A	c.(4855-4857)TCC>TAC	p.S1619Y		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	1619	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	AGCGTTCAGGGACAAAATGGT	0.408			NA											51	191					5.82388e-19	7.79504e-19	0.01441	1	0
AHNAK	79026	broad.mit.edu	37	11	62293357	62293358	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr11:62293357_62293358delGA	uc001ntl.2	-	5	8831_8832	c.8531_8532delTC	c.(8530-8532)CTCfs	p.L2844fs	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2844					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TTGGACCTGTGAGATTCAGGTC	0.436			NA											12	307	---	---	---	---	NA	NA	NA	NA	NA
TKT	7086	broad.mit.edu	37	3	53264635	53264635	+	Frame_Shift_Del	DEL	T	T	-			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr3:53264635delT	uc003dgo.2	-	8	1055	c.945delA	c.(943-945)ATAfs	p.I315fs	TKT_uc003dgp.2_Translation_Start_Site|TKT_uc011beo.1_Frame_Shift_Del_p.I268fs|TKT_uc003dgq.2_Frame_Shift_Del_p.I315fs|TKT_uc011beq.1_Frame_Shift_Del_p.I323fs|TKT_uc011ber.1_Frame_Shift_Del_p.I117fs|TKT_uc011bep.1_Frame_Shift_Del_p.I232fs	NM_001135055	NP_001128527	P29401	TKT_HUMAN	transketolase isoform 1	315					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|transketolase activity			ovary(2)	2		Prostate(884;0.0959)		BRCA - Breast invasive adenocarcinoma(193;0.000159)|OV - Ovarian serous cystadenocarcinoma(275;0.000314)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)	Thiamine(DB00152)	TGCGGGTGGCTATCTGTGAGG	0.607	Colon(133;1506 2347 35238 42177)		NA											27	65	---	---	---	---	NA	NA	NA	NA	NA
MTTP	4547	broad.mit.edu	37	4	100540140	100540140	+	Frame_Shift_Del	DEL	T	T	-			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr4:100540140delT	uc003hvc.3	+	17	2483	c.2227delT	c.(2227-2229)TTAfs	p.L743fs	MTTP_uc011cej.1_Frame_Shift_Del_p.L770fs	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	743					lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	GGAACTTCAGTTACAATCTGG	0.363			NA											10	55	---	---	---	---	NA	NA	NA	NA	NA
GPR151	134391	broad.mit.edu	37	5	145895330	145895333	+	Frame_Shift_Del	DEL	CAGT	CAGT	-			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	CAGT	CAGT	-	-	CAGT	CAGT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chr5:145895330_145895333delCAGT	uc003lod.1	-	1	344_347	c.344_347delACTG	c.(343-348)GACTGGfs	p.D115fs		NM_194251	NP_919227	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	115_116	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTGGATAAACCAGTCAGAGGACTT	0.51	Pancreas(78;420 1386 18535 37114 49710)		NA											7	194	---	---	---	---	NA	NA	NA	NA	NA
POF1B	79983	broad.mit.edu	37	X	84561281	84561284	+	Frame_Shift_Del	DEL	AGAG	AGAG	-			TCGA-67-3774-01A-01D-1040-01	TCGA-67-3774-10A-01D-1489-08	AGAG	AGAG	-	-	AGAG	AGAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8074cbbf-acd2-45b3-9aa4-119711cf9855	bae1345a-b4bf-41a9-aa39-7c1b0844d4a3	g.chrX:84561281_84561284delAGAG	uc004eer.2	-	12	1366_1369	c.1220_1223delCTCT	c.(1219-1224)TCTCTTfs	p.S407fs	POF1B_uc004ees.2_Frame_Shift_Del_p.S407fs	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	407_408	Potential.						actin binding				0						TGTATGTCGAAGAGAGAGATTGTT	0.343			NA											11	42	---	---	---	---	NA	NA	NA	NA	NA
