Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CHD5	26038	broad.mit.edu	37	1	6188908	6188908	+	Silent	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:6188908G>A	uc001amb.1	-	23	3709	c.3609C>T	c.(3607-3609)GAC>GAT	p.D1203D	CHD5_uc001alz.1_Silent_p.D60D|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1203					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CCTCCACGTCGTCCTTGAAGA	0.672			NA											16	28					0	0	0.006122	0	0
BAI2	576	broad.mit.edu	37	1	32198202	32198202	+	Silent	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:32198202C>T	uc001btn.2	-	27	3990	c.3636G>A	c.(3634-3636)GTG>GTA	p.V1212V	BAI2_uc001btm.2_Silent_p.V206V|BAI2_uc001btp.1_Silent_p.V206V|BAI2_uc010ogn.1_Silent_p.V182V|BAI2_uc010ogo.1_Silent_p.V821V|BAI2_uc010ogp.1_Silent_p.V1145V|BAI2_uc010ogq.1_Silent_p.V1179V|BAI2_uc001bto.2_Silent_p.V1212V	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	1212	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		GGCACTTCACCACATCCTGGA	0.652			NA											5	29					0	0	0.000602	0	0
RNF19B	127544	broad.mit.edu	37	1	33402700	33402700	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:33402700G>T	uc010oho.1	-	9	1906	c.1906C>A	c.(1906-1908)CCC>ACC	p.P636T	RNF19B_uc001bwm.3_3'UTR|RNF19B_uc010ohp.1_Missense_Mutation_p.P635T	NM_153341	NP_699172	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B isoform a	636						integral to membrane	ligase activity|protein binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TGTCTGCAGGGGGGATCCTCT	0.567			NA											17	145					4.35082e-09	5.57517e-09	0.010504	1	0
RAB3B	5865	broad.mit.edu	37	1	52442781	52442781	+	Silent	SNP	T	T	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:52442781T>C	uc001cth.2	-	2	134	c.9A>G	c.(7-9)TCA>TCG	p.S3S		NM_002867	NP_002858	P20337	RAB3B_HUMAN	RAB3B, member RAS oncogene family	3					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(1)	1						CATCTGTCACTGAAGCCATCT	0.468			NA											22	58					0	0	0.012319	0	0
WLS	79971	broad.mit.edu	37	1	68620819	68620819	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:68620819T>C	uc001def.1	-	4	900	c.629A>G	c.(628-630)AAT>AGT	p.N210S	uc001deb.1_Intron|uc001dec.1_Intron|WLS_uc001dee.2_Missense_Mutation_p.N208S|WLS_uc001deg.1_Missense_Mutation_p.N119S|WLS_uc009wbf.1_Missense_Mutation_p.N165S	NM_024911	NP_079187	Q5T9L3	WLS_HUMAN	G protein-coupled receptor 177 isoform 1	210	Lumenal (Potential).|Interacts with Wnt proteins (By similarity).				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity				0						AATTCCCACATTGATTTTCTT	0.398			NA											81	182					0	0	0.01441	0	0
SLC44A5	204962	broad.mit.edu	37	1	75805301	75805301	+	Missense_Mutation	SNP	A	A	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:75805301A>T	uc001dgu.2	-	4	211	c.67T>A	c.(67-69)TAT>AAT	p.Y23N	SLC44A5_uc001dgt.2_Missense_Mutation_p.Y23N|SLC44A5_uc001dgs.2_5'UTR|SLC44A5_uc001dgr.2_5'UTR|SLC44A5_uc010oqz.1_Missense_Mutation_p.Y62N|SLC44A5_uc010ora.1_Missense_Mutation_p.Y17N|SLC44A5_uc010orb.1_5'UTR	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	23	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						TCTGGGTCATATGTCCTTGGA	0.343			NA											165	306					0	0	0.01441	0	0
ST6GALNAC3	256435	broad.mit.edu	37	1	77093235	77093235	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:77093235C>T	uc001dhh.2	+	4	885	c.722C>T	c.(721-723)ACC>ATC	p.T241I	ST6GALNAC3_uc010orh.1_Intron	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	241	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						ATAAATGACACCTACTGCAAG	0.403			NA											29	117					0	0	0.010818	0	0
GBP5	115362	broad.mit.edu	37	1	89732742	89732742	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:89732742C>A	uc001dnc.2	-	6	1060	c.523G>T	c.(523-525)GAC>TAC	p.D175Y	GBP5_uc001dnd.2_Missense_Mutation_p.D175Y|GBP5_uc001dne.1_Missense_Mutation_p.D175Y	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	175						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		CACACTAAGTCTGGGAAGAAG	0.488			NA											44	140					1.7489e-18	2.62336e-18	0.011902	1	0
S100A13	6284	broad.mit.edu	37	1	153591462	153591462	+	Missense_Mutation	SNP	G	G	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:153591462G>C	uc001fcf.3	-	3	365	c.206C>G	c.(205-207)TCG>TGG	p.S69W	S100A14_uc001fce.2_5'Flank|S100A13_uc001fcg.2_Missense_Mutation_p.S69W|S100A13_uc009woh.2_Missense_Mutation_p.S69W|S100A13_uc001fch.2_Missense_Mutation_p.S69W|S100A13_uc001fci.2_Missense_Mutation_p.S69W|S100A13_uc001fcj.2_Missense_Mutation_p.S69W	NM_001024213	NP_001019384	Q99584	S10AD_HUMAN	S100 calcium binding protein A13	69	2.				interleukin-1 alpha secretion|mast cell degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|extracellular space|nucleus|perinuclear region of cytoplasm	calcium ion binding|copper ion binding|fibroblast growth factor 1 binding|lipid binding|protein homodimerization activity|RAGE receptor binding|zinc ion binding				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)		Amlexanox(DB01025)	CTTGAGCTCCGAGTCCTGATT	0.483	NSCLC(156;1296 1989 17590 30930 49554)		NA											15	407					0	0	0.007413	0	0
GATAD2B	57459	broad.mit.edu	37	1	153790562	153790562	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:153790562C>A	uc001fdb.3	-	5	927	c.683G>T	c.(682-684)CGG>CTG	p.R228L		NM_020699	NP_065750	Q8WXI9	P66B_HUMAN	GATA zinc finger domain containing 2B	228						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGCCCCAGGCCGAGAGGGAAG	0.517			NA											42	170					3.61848e-18	5.39598e-18	0.007835	1	0
NUP210L	91181	broad.mit.edu	37	1	153998192	153998192	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:153998192C>A	uc001fdw.2	-	30	4020	c.3948G>T	c.(3946-3948)AGG>AGT	p.R1316S	NUP210L_uc009woq.2_Missense_Mutation_p.R225S|NUP210L_uc010peh.1_Missense_Mutation_p.R1316S	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1316						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			CAGCTCCTTCCCTAGGGAACA	0.473			NA											14	280					0.00316338	0.00344727	0.003163	1	0
SPTA1	6708	broad.mit.edu	37	1	158656297	158656297	+	Missense_Mutation	SNP	A	A	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:158656297A>G	uc001fst.1	-	1	210	c.11T>C	c.(10-12)TTT>TCT	p.F4S		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	4					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TTCCTTTGGAAATTGCTCCAT	0.333			NA											4	98					0	0	0.009096	0	0
RASAL2	9462	broad.mit.edu	37	1	178421741	178421741	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:178421741C>G	uc001glr.2	+	9	1644	c.1519C>G	c.(1519-1521)CTA>GTA	p.L507V	RASAL2_uc001glq.2_Missense_Mutation_p.L655V|RASAL2_uc009wxc.2_Missense_Mutation_p.L21V	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	507	Ras-GAP.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						ATCTCGGACTCTAACTCTTAT	0.423			NA											7	178					0	0	0.004482	0	0
CACNA1E	777	broad.mit.edu	37	1	181726250	181726250	+	Silent	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:181726250G>T	uc001gow.2	+	30	4482	c.4317G>T	c.(4315-4317)CTG>CTT	p.L1439L	CACNA1E_uc009wxs.2_Silent_p.L1327L|CACNA1E_uc001gox.1_Silent_p.L665L|CACNA1E_uc009wxt.2_Silent_p.L665L	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1439	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						AGTGCAGCCTGGAGAAGAATG	0.468			NA											6	43					0.00116845	0.00128428	0.001168	1	0
CNTN2	6900	broad.mit.edu	37	1	205035635	205035635	+	Nonsense_Mutation	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:205035635G>A	uc001hbr.2	+	15	2152	c.1883G>A	c.(1882-1884)TGG>TAG	p.W628*	CNTN2_uc001hbq.1_Nonsense_Mutation_p.W519*|CNTN2_uc001hbs.2_Nonsense_Mutation_p.W416*	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	628	Fibronectin type-III 1.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CAGCTCAGCTGGAGCCGTGGC	0.607	Melanoma(183;2548 2817 37099 41192)		NA											19	30					0	0	0.008871	0	0
ELK4	2005	broad.mit.edu	37	1	205588203	205588203	+	Splice_Site	SNP	T	T	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:205588203T>A	uc001hcy.1	-	4	2331	c.1081_splice	c.e4-1	p.T361_splice		NM_001973	NP_001964	P28324	ELK4_HUMAN	ELK4 protein isoform a							cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity				0	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			GATGGGTGTCTGCAATACACA	0.453			NA	T	SLC45A3	prostate								36	43					0	0	0.004289	0	0
CR1	1378	broad.mit.edu	37	1	207741262	207741262	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:207741262C>A	uc001hfy.2	+	17	2836	c.2696C>A	c.(2695-2697)ACA>AAA	p.T899K	CR1_uc009xcl.1_Missense_Mutation_p.T449K|CR1_uc001hfx.2_Missense_Mutation_p.T1349K|CR1_uc009xck.1_Missense_Mutation_p.T449K	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	899	Extracellular (Potential).|Sushi 14.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						GTAAATTACACATGCGACCCC	0.498			NA											73	159					2.40041e-21	3.75525e-21	0.01441	1	0
KCNH1	3756	broad.mit.edu	37	1	211192451	211192451	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:211192451G>T	uc001hib.2	-	6	876	c.706C>A	c.(706-708)CCT>ACT	p.P236T	KCNH1_uc001hic.2_Missense_Mutation_p.P236T	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	236	Helical; Name=Segment S1; (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		ACATTATAAGGGACCAAGATG	0.418			NA											44	58					2.47872e-24	3.92593e-24	0.010771	1	0
USH2A	7399	broad.mit.edu	37	1	216108066	216108066	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:216108066G>A	uc001hku.1	-	38	7579	c.7192C>T	c.(7192-7194)CTC>TTC	p.L2398F		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2398	Extracellular (Potential).|Fibronectin type-III 10.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCATCGATGAGCACCCAAAGG	0.358			NA								HNSCC(13;0.011)			73	92					0	0	0.01441	0	0
HLX	3142	broad.mit.edu	37	1	221053723	221053723	+	Missense_Mutation	SNP	A	A	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:221053723A>G	uc001hmv.3	+	1	981	c.524A>G	c.(523-525)AAA>AGA	p.K175R		NM_021958	NP_068777	Q14774	HLX_HUMAN	H2.0-like homeobox	175					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				GBM - Glioblastoma multiforme(131;0.00914)		AAAGACCTCAAATTTGGAATT	0.622			NA											12	51					0	0	0.010729	0	0
OR2M3	127062	broad.mit.edu	37	1	248366562	248366562	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:248366562C>A	uc010pzg.1	+	1	193	c.193C>A	c.(193-195)CAA>AAA	p.Q65K		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCTCCTCAGCCAACTGTCCCT	0.547			NA											75	331					9.35569e-46	1.55928e-45	0.01441	1	0
OR2T10	127069	broad.mit.edu	37	1	248756148	248756148	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:248756148G>T	uc010pzn.1	-	1	922	c.922C>A	c.(922-924)CAG>AAG	p.Q308K		NM_001004693	NP_001004693	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T,	308	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGAGGTTTCTGCACGCTCAGC	0.383			NA											42	19					3.54909e-21	5.45191e-21	0.011902	1	0
TUBB8	347688	broad.mit.edu	37	10	93905	93905	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr10:93905T>C	uc001ifi.2	-	4	427	c.427A>G	c.(427-429)ACT>GCT	p.T143A	TUBB8_uc009xhe.2_Missense_Mutation_p.T106A|TUBB8_uc010pzs.1_Missense_Mutation_p.T71A	NM_177987	NP_817124	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 isoform 1	143	GTP (Potential).				microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		CCAGACCCAGTCCCCCCACCC	0.587	Pancreas(192;2041 3010 9013 18103)		NA											3	60					0	0	0.004672	0	0
SFMBT2	57713	broad.mit.edu	37	10	7423846	7423846	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr10:7423846C>A	uc009xio.1	-	2	106	c.15G>T	c.(13-15)TTG>TTT	p.L5F	SFMBT2_uc001ijn.1_Missense_Mutation_p.L5F|SFMBT2_uc010qay.1_Missense_Mutation_p.L5F|SFMBT2_uc001ijo.1_Missense_Mutation_p.L5F	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	5					regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						TGGAAGCTGACAAAGTGCTCT	0.398			NA											12	45					0.000151284	0.000170697	0.001855	1	0
ITGA8	8516	broad.mit.edu	37	10	15646211	15646211	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr10:15646211T>C	uc001ioc.1	-	20	2114	c.2114A>G	c.(2113-2115)AAC>AGC	p.N705S	ITGA8_uc010qcb.1_Missense_Mutation_p.N690S	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	705	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						CATTACCTTGTTGTTGCGTTC	0.378			NA											24	111					0	0	0.00333	0	0
C10orf68	79741	broad.mit.edu	37	10	33137562	33137562	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr10:33137562C>T	uc001iwn.3	+	19	2013	c.1540C>T	c.(1540-1542)CGT>TGT	p.R514C	C10orf68_uc001iwl.1_Missense_Mutation_p.R473C|C10orf68_uc001iwm.1_Missense_Mutation_p.R518C|C10orf68_uc010qei.1_Missense_Mutation_p.R490C|C10orf68_uc001iwo.3_RNA	NM_024688	NP_078964	Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	514										skin(2)|ovary(1)	3						GTCCGTACAACGTCAAGAAGG	0.294			NA											10	80					0	0	0.010729	0	0
MSMB	4477	broad.mit.edu	37	10	51562320	51562320	+	Nonsense_Mutation	SNP	A	A	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr10:51562320A>T	uc001jiq.2	+	4	297	c.265A>T	c.(265-267)AAG>TAG	p.K89*	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron|MSMB_uc001jir.2_Silent_p.S53S|NCOA4_uc009xon.2_5'Flank|NCOA4_uc010qhd.1_5'Flank|NCOA4_uc001jis.3_5'Flank|NCOA4_uc010qhe.1_5'Flank|NCOA4_uc010qhf.1_5'Flank	NM_002443	NP_002434	P08118	MSMB_HUMAN	beta-microseminoprotein isoform a precursor	89						extracellular space|nucleus				ovary(2)	2						AAGAATCTTCAAGAAGGAGGA	0.448			NA							Hereditary_Prostate_Cancer				25	148					0	0	0.00333	0	0
KIF20B	9585	broad.mit.edu	37	10	91469165	91469165	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr10:91469165C>T	uc001kgs.1	+	4	370	c.298C>T	c.(298-300)CGG>TGG	p.R100W	KIF20B_uc001kgr.1_Missense_Mutation_p.R100W	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	100	Kinesin-motor.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						CATCCTTGGTCGGTTAAGTGA	0.368			NA											16	147					0	0	0.004007	0	0
CPN1	1369	broad.mit.edu	37	10	101814132	101814132	+	Silent	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr10:101814132G>T	uc001kql.2	-	7	1343	c.1083C>A	c.(1081-1083)GTC>GTA	p.V361V		NM_001308	NP_001299	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1 precursor	361					proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(3)|pancreas(1)	4		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		TAATCCCACTGACAGAAATGA	0.448			NA											15	73					1.15088e-07	1.41093e-07	0.004007	1	0
CCDC147	159686	broad.mit.edu	37	10	106125670	106125670	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr10:106125670G>T	uc001kyh.2	+	5	830	c.696G>T	c.(694-696)ATG>ATT	p.M232I		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	232	Potential.									ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		AGGCAGACATGGACAGCAGGC	0.502			NA											7	28					8.12818e-05	9.21194e-05	0.001984	1	0
PNLIPRP2	5408	broad.mit.edu	37	10	118383478	118383478	+	Missense_Mutation	SNP	A	A	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr10:118383478A>T	uc001lcq.2	+	5	98	c.75A>T	c.(73-75)CAA>CAT	p.Q25H	PNLIPRP2_uc009xyu.1_RNA|PNLIPRP2_uc009xyv.1_RNA	NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2	24					galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)		GCTACGGACAACTTGGCTGCT	0.488			NA											13	41					0	0	0.004007	0	0
OR51A7	119687	broad.mit.edu	37	11	4929304	4929304	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr11:4929304G>T	uc010qyq.1	+	1	705	c.705G>T	c.(703-705)AAG>AAT	p.K235N		NM_001004749	NP_001004749	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGAGGCTTAAGGCCCTAAATA	0.478			NA											35	124					9.78485e-24	1.54021e-23	0.013726	1	0
OR52H1	390067	broad.mit.edu	37	11	5565818	5565818	+	Silent	SNP	T	T	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr11:5565818T>A	uc010qzh.1	-	1	936	c.936A>T	c.(934-936)ATA>ATT	p.I312I	HBG2_uc001mak.1_Intron	NM_001005289	NP_001005289	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H,	312	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAAACAAAAGTATAACCTTAT	0.358			NA											16	50					0	0	0.00499	0	0
NELL1	4745	broad.mit.edu	37	11	21594952	21594952	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr11:21594952C>A	uc001mqe.2	+	19	2532	c.2379C>A	c.(2377-2379)TGC>TGA	p.C793*	NELL1_uc001mqf.2_Nonsense_Mutation_p.C746*|NELL1_uc009yid.2_Nonsense_Mutation_p.C821*|NELL1_uc010rdo.1_Nonsense_Mutation_p.C736*|NELL1_uc010rdp.1_Nonsense_Mutation_p.C506*|NELL1_uc001mqh.2_Nonsense_Mutation_p.C338*	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	793	VWFC 5.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						CCTGTAAATGCAAGGTAATTG	0.468			NA											21	78					2.98393e-07	3.60617e-07	0.00278	1	0
MUC15	143662	broad.mit.edu	37	11	26582625	26582625	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr11:26582625C>T	uc001mqx.2	-	4	1258	c.992G>A	c.(991-993)CGT>CAT	p.R331H	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Missense_Mutation_p.R358H|MUC15_uc001mqy.2_Missense_Mutation_p.R308H	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b	331	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						TACAGAAGTACGAAGTGGAGG	0.378			NA											8	106					0	0	0.00308	0	0
OR5D13	390142	broad.mit.edu	37	11	55541680	55541680	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr11:55541680C>A	uc010ril.1	+	1	767	c.767C>A	c.(766-768)ACT>AAT	p.T256N		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	256	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				TTCCATGGAACTATCCTTTTC	0.448			NA											17	77					0.000566183	0.000630466	0.00499	1	0
OR5T3	390154	broad.mit.edu	37	11	56020310	56020310	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr11:56020310C>A	uc010rjd.1	+	1	635	c.635C>A	c.(634-636)CCT>CAT	p.P212H		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	212	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					TGTGATATGCCTCCTCTCCTT	0.408			NA											91	187					3.60193e-44	5.88776e-44	0.01441	1	0
OR8K3	219473	broad.mit.edu	37	11	56086612	56086612	+	Missense_Mutation	SNP	A	A	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr11:56086612A>T	uc010rjf.1	+	1	830	c.830A>T	c.(829-831)TAC>TTC	p.Y277F		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	277	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					TCCATATTTTACACCCTGGTT	0.393			NA											25	53					0	0	0.004656	0	0
OR5M8	219484	broad.mit.edu	37	11	56258623	56258623	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr11:56258623T>C	uc001nix.1	-	1	224	c.224A>G	c.(223-225)AAT>AGT	p.N75S		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	75	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					TGGAGTCACATTGGAAGAGAA	0.473			NA											32	59					0	0	0.009535	0	0
OR5A1	219982	broad.mit.edu	37	11	59211538	59211538	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr11:59211538G>T	uc001nnx.1	+	1	897	c.897G>T	c.(895-897)GAG>GAT	p.E299D		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	299	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						GGAACAAAGAGATCAAGGATG	0.433			NA											61	124					1.79293e-35	2.91209e-35	0.01441	1	0
KCTD14	65987	broad.mit.edu	37	11	77728273	77728273	+	Missense_Mutation	SNP	G	G	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr11:77728273G>C	uc001oyw.3	-	2	159	c.134C>G	c.(133-135)ACC>AGC	p.T45S		NM_023930	NP_076419	Q9BQ13	KCD14_HUMAN	potassium channel tetramerisation domain	45	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1e-24)			CAGGGTGGTGGTGTGGAACTC	0.582	NSCLC(86;414 1416 18100 32729 49271)|Esophageal Squamous(156;1132 1858 11406 36132 46748)		NA											20	34					0	0	0.010504	0	0
GRM5	2915	broad.mit.edu	37	11	88780748	88780748	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr11:88780748G>T	uc001pcq.2	-	1	493	c.293C>A	c.(292-294)TCC>TAC	p.S98Y	GRM5_uc009yvm.2_Missense_Mutation_p.S98Y|GRM5_uc009yvn.1_Missense_Mutation_p.S98Y	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	98	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	ATGCCAGCAGGAGTCCCTTAT	0.517			NA											18	20					1.33834e-09	1.73236e-09	0.007413	1	0
AMOTL1	154810	broad.mit.edu	37	11	94532826	94532826	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr11:94532826G>A	uc001pfb.2	+	3	640	c.470G>A	c.(469-471)CGC>CAC	p.R157H	AMOTL1_uc001pfc.2_Missense_Mutation_p.R107H	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	157						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				CAGTCAGCACGCCAAGAACCG	0.547			NA											5	18					0	0	0.000602	0	0
LAYN	143903	broad.mit.edu	37	11	111425981	111425981	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr11:111425981A>C	uc001plr.1	+	6	984	c.648A>C	c.(646-648)GAA>GAC	p.E216D	LAYN_uc001plp.1_Missense_Mutation_p.E208D|LAYN_uc001plq.1_Missense_Mutation_p.E216D|LAYN_uc001pls.1_Missense_Mutation_p.E208D|LAYN_uc010rwg.1_Missense_Mutation_p.E63D|LAYN_uc010rwh.1_Missense_Mutation_p.E64D	NM_178834	NP_849156	Q6UX15	LAYN_HUMAN	layilin	216	Extracellular (Potential).					cell surface|integral to membrane|ruffle	hyaluronic acid binding|sugar binding				0		all_cancers(61;9.06e-10)|all_epithelial(67;1.34e-05)|Melanoma(852;1.74e-05)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.086)		Epithelial(105;1.5e-06)|BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|all cancers(92;2.45e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0476)		AAACACAGGAAGAAGATGCCA	0.403	Ovarian(17;551 586 12136 22082 22900)		NA											6	58					0	0	0.00308	0	0
HYOU1	10525	broad.mit.edu	37	11	118922237	118922237	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr11:118922237T>C	uc001puu.2	-	13	1632	c.1439A>G	c.(1438-1440)AAA>AGA	p.K480R	HYOU1_uc001put.2_Missense_Mutation_p.K445R|HYOU1_uc010ryu.1_Missense_Mutation_p.K500R|HYOU1_uc010ryv.1_Missense_Mutation_p.K369R|HYOU1_uc001pux.3_Missense_Mutation_p.K480R|HYOU1_uc010ryw.1_RNA|HYOU1_uc001puw.1_Missense_Mutation_p.K480R	NM_006389	NP_006380	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1 precursor	480						endoplasmic reticulum lumen	ATP binding|protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		GGTGATGACTTTGCGTTGAGG	0.562			NA											21	49					0	0	0.010504	0	0
GRIK4	2900	broad.mit.edu	37	11	120690598	120690598	+	Silent	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr11:120690598C>T	uc001pxn.2	+	6	767	c.480C>T	c.(478-480)ACC>ACT	p.T160T	GRIK4_uc009zav.1_Silent_p.T160T|GRIK4_uc009zaw.1_Silent_p.T160T|GRIK4_uc009zax.1_Silent_p.T160T	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	160	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	TCAACTGCACCACCGCCTGCC	0.537			NA											8	198					0	0	0.008291	0	0
SLC6A13	6540	broad.mit.edu	37	12	330154	330154	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr12:330154G>T	uc001qic.1	-	15	1822	c.1769C>A	c.(1768-1770)ACC>AAC	p.T590N	SLC6A13_uc009zdj.1_Missense_Mutation_p.T580N|SLC6A13_uc010sdl.1_Missense_Mutation_p.T498N	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	590	Cytoplasmic (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			GAGCAGTGAGGTCCTGGGGGT	0.657			NA											6	26					0.00116845	0.00128428	0.001168	1	0
C12orf5	57103	broad.mit.edu	37	12	4459026	4459026	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr12:4459026T>G	uc001qmp.2	+	4	313	c.234T>G	c.(232-234)GAT>GAG	p.D78E		NM_020375	NP_065108	Q9NQ88	TIGAR_HUMAN	TP53-induced glycolysis and apoptosis regulator	78						intracellular	fructose-2,6-bisphosphate 2-phosphatase activity			skin(1)	1			all cancers(3;1.15e-07)|Colorectal(7;0.00165)|OV - Ovarian serous cystadenocarcinoma(31;0.00596)|COAD - Colon adenocarcinoma(12;0.0229)|GBM - Glioblastoma multiforme(3;0.0266)|STAD - Stomach adenocarcinoma(119;0.206)			TTTGCAAAGATATGACGGTAA	0.353	Colon(1;100 192 35375 49454 52532)		NA											12	89					0	0	0.00245	0	0
C12orf5	57103	broad.mit.edu	37	12	4459029	4459029	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr12:4459029G>T	uc001qmp.2	+	4	316	c.237G>T	c.(235-237)ATG>ATT	p.M79I		NM_020375	NP_065108	Q9NQ88	TIGAR_HUMAN	TP53-induced glycolysis and apoptosis regulator	79						intracellular	fructose-2,6-bisphosphate 2-phosphatase activity			skin(1)	1			all cancers(3;1.15e-07)|Colorectal(7;0.00165)|OV - Ovarian serous cystadenocarcinoma(31;0.00596)|COAD - Colon adenocarcinoma(12;0.0229)|GBM - Glioblastoma multiforme(3;0.0266)|STAD - Stomach adenocarcinoma(119;0.206)			GCAAAGATATGACGGTAAAGT	0.348	Colon(1;100 192 35375 49454 52532)		NA											11	87					4.36969e-10	5.77343e-10	0.001855	1	0
ALG10B	144245	broad.mit.edu	37	12	38714267	38714267	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr12:38714267G>T	uc001rln.3	+	3	813	c.674G>T	c.(673-675)GGA>GTA	p.G225V	ALG10B_uc001rlo.3_Missense_Mutation_p.G195V|ALG10B_uc010skk.1_Missense_Mutation_p.G165V	NM_001013620	NP_001013642	Q5I7T1	AG10B_HUMAN	asparagine-linked glycosylation 10 homolog B	225	Cytoplasmic (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			ovary(2)|skin(1)	3	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				CCTATTAAAGGACCATTTGCA	0.393			NA											21	111					3.65163e-15	5.29071e-15	0.00632	1	0
ARID2	196528	broad.mit.edu	37	12	46243560	46243560	+	Splice_Site	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr12:46243560G>T	uc001ros.1	+	14	1912	c.1912_splice	c.e14+1	p.G638_splice	ARID2_uc001ror.2_Splice_Site_p.G638_splice|ARID2_uc009zkg.1_Splice_Site_p.G94_splice|ARID2_uc009zkh.1_Splice_Site_p.G265_splice|ARID2_uc001rou.1_5'Flank	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TCACCTGCAGGTGTTAATTTT	0.313			NA											14	128					9.31168e-06	1.08424e-05	0.001855	1	0
KRT75	9119	broad.mit.edu	37	12	52825359	52825359	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr12:52825359C>T	uc001saj.2	-	4	860	c.838G>A	c.(838-840)GAG>AAG	p.E280K		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	280	Coil 1B.|Rod.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		AAGTTGATCTCCTCGGGCAGA	0.483			NA											4	55					0	0	0.001168	0	0
KRT1	3848	broad.mit.edu	37	12	53072009	53072009	+	Splice_Site	SNP	T	T	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr12:53072009T>C	uc001sau.1	-	3	866	c.807_splice	c.e3-1	p.K269_splice	KRT1_uc001sav.1_Splice_Site_p.K269_splice	NM_006121	NP_006112	P04264	K2C1_HUMAN	keratin 1						complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			ovary(1)|skin(1)	2						TCCTCATACCTGCAGGAAAGC	0.403			NA											9	25					0	0	0.006214	0	0
LRIG3	121227	broad.mit.edu	37	12	59272706	59272706	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr12:59272706G>T	uc001sqr.2	-	14	2229	c.1983C>A	c.(1981-1983)TTC>TTA	p.F661L	LRIG3_uc009zqh.2_Missense_Mutation_p.F601L|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	661	Ig-like C2-type 2.					integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			CCACGATAAAGAACACGTCAT	0.542			NA											9	79					0.00448238	0.00482282	0.004482	1	0
NAV3	89795	broad.mit.edu	37	12	78582552	78582552	+	Missense_Mutation	SNP	T	T	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr12:78582552T>A	uc001syp.2	+	33	6223	c.6050T>A	c.(6049-6051)CTC>CAC	p.L2017H	NAV3_uc001syo.2_Missense_Mutation_p.L1995H|NAV3_uc010sub.1_Missense_Mutation_p.L1474H|NAV3_uc009zsf.2_Missense_Mutation_p.L826H	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	2017						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						ACTGTGAACCTCAAAGGTAAA	0.378			NA								HNSCC(70;0.22)			16	44					0	0	0.003163	0	0
LUM	4060	broad.mit.edu	37	12	91502379	91502379	+	Missense_Mutation	SNP	G	G	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr12:91502379G>C	uc001tbm.2	-	2	767	c.378C>G	c.(376-378)AAC>AAG	p.N126K	LUM_uc001tbn.2_Intron	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	126	LRR 3.				collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)	2						CTGTCAGGTTGTTGTGGTTTA	0.418			NA											20	74					0	0	0.010504	0	0
TBX5	6910	broad.mit.edu	37	12	114837318	114837318	+	Nonsense_Mutation	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr12:114837318C>T	uc001tvo.2	-	4	857	c.362G>A	c.(361-363)TGG>TAG	p.W121*	TBX5_uc001tvp.2_Nonsense_Mutation_p.W121*|TBX5_uc001tvq.2_Nonsense_Mutation_p.W71*|TBX5_uc010syv.1_Nonsense_Mutation_p.W121*	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	121	T-box.				cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		CAGTGCCTACCATTTATTATC	0.418	NSCLC(152;1358 1980 4050 23898 40356)		NA											21	123					0	0	0.00333	0	0
HSPH1	10808	broad.mit.edu	37	13	31719733	31719733	+	Silent	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr13:31719733C>A	uc001utj.2	-	11	1949	c.1551G>T	c.(1549-1551)CTG>CTT	p.L517L	HSPH1_uc001utk.2_Silent_p.L517L|HSPH1_uc010aaw.2_Silent_p.L476L|HSPH1_uc001utl.2_Silent_p.L519L|HSPH1_uc010tds.1_Silent_p.L441L	NM_006644	NP_006635	Q92598	HS105_HUMAN	heat shock 105kD	517					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		GTCTCTGATTCAGACACTCCA	0.423			NA											6	42					0.00116845	0.00128428	0.001168	1	0
KL	9365	broad.mit.edu	37	13	33634951	33634951	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr13:33634951C>A	uc001uus.2	+	4	1743	c.1735C>A	c.(1735-1737)CAG>AAG	p.Q579K	KL_uc001uur.1_3'UTR	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	579	Glycosyl hydrolase-1 2.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		TGCTGCCATCCAGCCCCAGAT	0.498			NA											34	57					1.30998e-17	1.94213e-17	0.005524	1	0
TRPC4	7223	broad.mit.edu	37	13	38237641	38237641	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr13:38237641G>T	uc001uws.2	-	6	1835	c.1600C>A	c.(1600-1602)CTA>ATA	p.L534I	TRPC4_uc010abv.2_Missense_Mutation_p.L114I|TRPC4_uc001uwt.2_Missense_Mutation_p.L534I|TRPC4_uc010tey.1_Missense_Mutation_p.L534I|TRPC4_uc010abw.2_Missense_Mutation_p.L361I|TRPC4_uc010abx.2_Missense_Mutation_p.L534I|TRPC4_uc010aby.2_Missense_Mutation_p.L534I	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	534	Extracellular (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		AATTGATTTAGGCCATTTGCA	0.373			NA											4	73					0.00024832	0.00027895	0.009096	1	0
STOML3	161003	broad.mit.edu	37	13	39546705	39546705	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr13:39546705C>A	uc001uwx.2	-	4	394	c.256G>T	c.(256-258)GAT>TAT	p.D86Y	STOML3_uc010tez.1_Missense_Mutation_p.D77Y	NM_145286	NP_660329	Q8TAV4	STML3_HUMAN	stomatin-like 3 isoform 1	86	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)	1		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		ACAAACACATCTATGCATGGC	0.373			NA											32	82					2.20474e-14	3.15847e-14	0.003755	1	0
PCDH9	5101	broad.mit.edu	37	13	67801795	67801796	+	Missense_Mutation	DNP	GC	GC	TG			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr13:67801795_67801796GC>TG	uc001vik.2	-	2	1469_1470	c.777_778GC>CA	c.(775-780)GTGCAT>GTCAAT	p.H260N	PCDH9_uc001vil.2_Missense_Mutation_p.H260N|PCDH9_uc010thl.1_Missense_Mutation_p.H260N|PCDH9_uc001vin.3_Missense_Mutation_p.H260N	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	260	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TCTGGAATATGCACCTCCACTT	0.47			NA											5	62					0	0	0.004672	0	0
SLITRK6	84189	broad.mit.edu	37	13	86369625	86369626	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr13:86369625_86369626GG>TT	uc001vll.1	-	2	1477_1478	c.1018_1019CC>AA	c.(1018-1020)CCA>AAA	p.P340K	SLITRK6_uc010afe.1_Missense_Mutation_p.P105K	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	340	Extracellular (Potential).|LRRNT 2.					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		AAGTCCTGATGGGGATAGGACT	0.446			NA											35	75					0	0	0.004672	0	0
OR11H12	440153	broad.mit.edu	37	14	19377684	19377684	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr14:19377684G>T	uc010tkp.1	+	1	91	c.91G>T	c.(91-93)GGT>TGT	p.G31C		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H,	31	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TATACTCCAAGGTTTCACTTG	0.413			NA											21	148					7.45023e-12	1.03815e-11	0.010504	1	0
PRKD1	5587	broad.mit.edu	37	14	30100003	30100003	+	Silent	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr14:30100003G>A	uc001wqh.2	-	10	1798	c.1617C>T	c.(1615-1617)GCC>GCT	p.A539A		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	539	PH.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		CGGGCATAAGGGCATGCTGGA	0.537			NA											7	109					0	0	0.001984	0	0
STRN3	29966	broad.mit.edu	37	14	31374737	31374737	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr14:31374737A>C	uc001wqu.2	-	15	2132	c.1916T>G	c.(1915-1917)TTT>TGT	p.F639C	STRN3_uc001wqv.2_Missense_Mutation_p.F555C|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	639					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		ACAGCCTATAAAGTCAACTGA	0.348			NA											5	165					0	0	0.001168	0	0
AHNAK2	113146	broad.mit.edu	37	14	105412058	105412058	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr14:105412058G>T	uc010axc.1	-	7	9850	c.9730C>A	c.(9730-9732)CCC>ACC	p.P3244T	AHNAK2_uc001ypx.2_Missense_Mutation_p.P3144T	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3244						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCTATCTGGGGGCCCTTGCGA	0.612			NA											21	61					1.04352e-10	1.40792e-10	0.003755	1	0
DUOX1	53905	broad.mit.edu	37	15	45444641	45444641	+	Silent	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr15:45444641C>T	uc001zus.1	+	26	3697	c.3351C>T	c.(3349-3351)CTC>CTT	p.L1117L	DUOX1_uc001zut.1_Silent_p.L1117L|DUOX1_uc010bee.1_Silent_p.L497L|DUOX1_uc001zuu.2_Silent_p.L259L	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	1117	Ferric oxidoreductase.|Interaction with TXNDC11 (By similarity).|Cytoplasmic (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity	p.L1117L(1)		ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		AAACCTTCCTCAACCGCTACG	0.612			NA											4	33					0	0	0.001168	0	0
GATM	2628	broad.mit.edu	37	15	45661562	45661562	+	Missense_Mutation	SNP	C	C	A	rs80338737		TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr15:45661562C>A	uc001zvc.2	-	3	775	c.446G>T	c.(445-447)TGG>TTG	p.W149L	GATM_uc001zvb.2_Missense_Mutation_p.W20L|GATM_uc010uev.1_Missense_Mutation_p.W202L	NM_001482	NP_001473	P50440	GATM_HUMAN	L-arginine:glycine amidinotransferase precursor	149					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding				0		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	CTTCAATGACCAGTCAATGGG	0.373			NA											24	96					7.41945e-09	9.4598e-09	0.005443	1	0
ATP8B4	79895	broad.mit.edu	37	15	50271825	50271825	+	Silent	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr15:50271825G>A	uc001zxu.2	-	12	1165	c.1023C>T	c.(1021-1023)TCC>TCT	p.S341S	ATP8B4_uc010ber.2_Silent_p.S214S|ATP8B4_uc010ufd.1_Silent_p.S214S|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	341	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TCACATATAAGGAAATGGGTA	0.308			NA											10	139					0	0	0.010729	0	0
VPS13C	54832	broad.mit.edu	37	15	62226466	62226466	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr15:62226466A>C	uc002agz.2	-	49	5894	c.5820T>G	c.(5818-5820)TTT>TTG	p.F1940L	VPS13C_uc002aha.2_Missense_Mutation_p.F1897L|VPS13C_uc002ahb.1_Missense_Mutation_p.F1940L|VPS13C_uc002ahc.1_Missense_Mutation_p.F1897L	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	1940					protein localization					ovary(2)	2						ATTCAAAGTGAAAGTCAAATT	0.318			NA											16	160					0	0	0.006122	0	0
LOC645752	645752	broad.mit.edu	37	15	78207569	78207569	+	Missense_Mutation	SNP	G	G	A	rs56314252	by1000genomes	TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr15:78207569G>A	uc010bky.2	-	18	2107	c.1343C>T	c.(1342-1344)GCA>GTA	p.A448V	LOC645752_uc010umq.1_Missense_Mutation_p.A95V|uc002bcw.1_5'Flank|uc002bcx.1_5'Flank	NR_027024				SubName: Full=GOLGA6 protein; Flags: Fragment;												0						GATCTGCTGTGCAGTGGGGTT	0.572			NA											4	56					0	0	0.001168	0	0
ALPK3	57538	broad.mit.edu	37	15	85411371	85411371	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr15:85411371C>T	uc002ble.2	+	14	5575	c.5408C>T	c.(5407-5409)CCT>CTT	p.P1803L	ALPK3_uc010upc.1_Missense_Mutation_p.P104L	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1803	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGCTGCTTCCCTGCCCTGCTG	0.647			NA											19	138					0	0	0.008871	0	0
TPSG1	25823	broad.mit.edu	37	16	1272752	1272752	+	Silent	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr16:1272752G>T	uc002ckw.2	-	4	413	c.411C>A	c.(409-411)CTC>CTA	p.L137L		NM_012467	NP_036599	Q9NRR2	TRYG1_HUMAN	transmembrane tryptase preproprotein	137	Peptidase S1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				TCCGGCTGGAGAGGGTCACGG	0.682			NA											12	39					2.27111e-07	2.75778e-07	0.013537	1	0
TMEM204	79652	broad.mit.edu	37	16	1604799	1604799	+	Silent	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr16:1604799C>A	uc002cmc.2	+	4	851	c.453C>A	c.(451-453)ATC>ATA	p.I151I	IFT140_uc002clz.2_Intron|IFT140_uc002cmb.2_Intron|TMEM204_uc002cmd.2_Silent_p.I151I|TMEM204_uc010brr.1_Silent_p.I151I|uc010brs.1_5'Flank	NM_024600	NP_078876	Q9BSN7	TM204_HUMAN	transmembrane protein 204	151	Helical; (Potential).				response to stress	adherens junction|integral to membrane					0		Hepatocellular(780;0.219)				TCCTGGTCATCGGGCTCGTGA	0.587			NA											35	67					3.09479e-21	4.78285e-21	0.006999	1	0
Unknown	0	broad.mit.edu	37	16	28354495	28354495	+	Silent	SNP	T	T	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr16:28354495T>C	uc010vcq.1	-	7	710	c.657A>G	c.(655-657)GCA>GCG	p.A219A	uc010vcr.1_Silent_p.A237A					SubName: Full=LOC728741 protein;												NA						GATGCTCCGCTGCCACCATTC	0.493			NA											5	73					0	0	0.000602	0	0
ITGAL	3683	broad.mit.edu	37	16	30522454	30522454	+	Missense_Mutation	SNP	A	A	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr16:30522454A>T	uc002dyi.3	+	24	2959	c.2783A>T	c.(2782-2784)CAG>CTG	p.Q928L	ITGAL_uc002dyj.3_Missense_Mutation_p.Q844L|ITGAL_uc010vev.1_Missense_Mutation_p.Q162L	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	928	Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	ATCCTCATCCAGGAGTAAGTT	0.577	NSCLC(110;1462 1641 3311 33990 49495)		NA											16	54					0	0	0.004007	0	0
BCAR1	9564	broad.mit.edu	37	16	75276608	75276608	+	Silent	SNP	C	C	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr16:75276608C>G	uc002fdv.2	-	2	516	c.393G>C	c.(391-393)CCG>CCC	p.P131P	BCAR1_uc010cgu.2_Silent_p.P102P|BCAR1_uc010vna.1_Silent_p.P129P|BCAR1_uc010vnb.1_Silent_p.P177P|BCAR1_uc002fdw.2_Silent_p.P131P|BCAR1_uc010vnc.1_Intron|BCAR1_uc010vnd.1_Silent_p.P149P|BCAR1_uc002fdx.2_Silent_p.P149P	NM_014567	NP_055382	P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	131	Substrate for kinases (By similarity).				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			central_nervous_system(5)|breast(2)|prostate(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.169)		GGCTGGGACCCGGGACTTGGT	0.632			NA											5	204					0	0	0.001984	0	0
NEURL4	84461	broad.mit.edu	37	17	7221815	7221815	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr17:7221815T>C	uc002gga.1	-	23	3870	c.3863A>G	c.(3862-3864)CAG>CGG	p.Q1288R	NEURL4_uc002gfy.1_RNA|GPS2_uc002gfz.1_5'UTR|NEURL4_uc002ggb.1_Missense_Mutation_p.Q1286R	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	1288	NHR 6.						protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						GCCACTAACCTGCTCACACTG	0.627			NA											3	12					0	0	0.004672	0	0
MYH2	4620	broad.mit.edu	37	17	10429087	10429087	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr17:10429087C>G	uc010coi.2	-	31	4422	c.4294G>C	c.(4294-4296)GAG>CAG	p.E1432Q	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.E1432Q|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1432	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						ATGAGGTCCTCGACCTCATTC	0.542			NA											43	56					0	0	0.011902	0	0
AATF	26574	broad.mit.edu	37	17	35388909	35388909	+	Splice_Site	SNP	A	A	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr17:35388909A>G	uc002hni.2	+	11	1799	c.1548_splice	c.e11-2	p.R516_splice	AATF_uc002hnj.2_Splice_Site	NM_012138	NP_036270	Q9NY61	AATF_HUMAN	apoptosis antagonizing transcription factor						anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of superoxide anion generation|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to DNA damage stimulus	centrosome|focal adhesion|nucleolus	leucine zipper domain binding|sequence-specific DNA binding transcription factor activity				0		Breast(25;0.00607)				TGCTTTATTTAGGTTTCATGT	0.388	NSCLC(49;901 1159 19183 41572 46244)		NA											4	123					0	0	0.000602	0	0
KRT222	125113	broad.mit.edu	37	17	38818199	38818199	+	Missense_Mutation	SNP	A	A	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr17:38818199A>T	uc002hvc.2	-	2	259	c.194T>A	c.(193-195)CTG>CAG	p.L65Q	KRT222_uc010wfk.1_RNA|KRT222_uc002hvb.2_Missense_Mutation_p.L25Q|KRT222_uc010cxc.2_Missense_Mutation_p.L25Q	NM_152349	NP_689562	Q8N1A0	KT222_HUMAN	truncated type I keratin KA21	65	Potential.					intermediate filament	structural molecule activity			central_nervous_system(1)|skin(1)	2						TTCCACTTGCAGGTGGTGCCA	0.458			NA											95	171					0	0	0.01441	0	0
DHX8	1659	broad.mit.edu	37	17	41594634	41594634	+	Missense_Mutation	SNP	A	A	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr17:41594634A>G	uc002idu.1	+	18	2816	c.2743A>G	c.(2743-2745)ACC>GCC	p.T915A	DHX8_uc010wif.1_Missense_Mutation_p.T824A|DHX8_uc010wig.1_Missense_Mutation_p.T915A	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	915	Helicase C-terminal.					catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		AATGCTGACCACCAACGTGCC	0.512	NSCLC(56;1548 1661 49258 49987)		NA											3	32					0	0	0.004672	0	0
FZD2	2535	broad.mit.edu	37	17	42635330	42635330	+	Silent	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr17:42635330C>T	uc002igx.1	+	1	406	c.274C>T	c.(274-276)CTG>TTG	p.L92L		NM_001466	NP_001457	Q14332	FZD2_HUMAN	frizzled 2 precursor	92	FZ.|Extracellular (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		GCGCTTCTTCCTGTGCTCCAT	0.642			NA											5	78					0	0	0.001984	0	0
BZRAP1	9256	broad.mit.edu	37	17	56389902	56389902	+	Silent	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr17:56389902C>A	uc002ivx.3	-	17	3151	c.2280G>T	c.(2278-2280)GTG>GTT	p.V760V	BZRAP1_uc010dcs.2_Silent_p.V700V|BZRAP1_uc010wnt.1_Silent_p.V760V	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	760						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGCTCCTTCCCACACTGCTTT	0.647			NA											21	54					5.35356e-11	7.33956e-11	0.00278	1	0
ARSG	22901	broad.mit.edu	37	17	66339822	66339822	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr17:66339822G>A	uc002jhc.2	+	3	1092	c.296G>A	c.(295-297)CGC>CAC	p.R99H	ARSG_uc002jhb.1_5'UTR	NM_014960	NP_055775	Q96EG1	ARSG_HUMAN	Arylsulfatase G precursor	99					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			CTTGGCCTTCGCAATGGAGTC	0.602			NA											5	49					0	0	0.001168	0	0
MRPS7	51081	broad.mit.edu	37	17	73261910	73261910	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr17:73261910C>T	uc002jnm.3	+	5	868	c.635C>T	c.(634-636)GCT>GTT	p.A212V	MRPS7_uc002jnn.3_Missense_Mutation_p.A241V	NM_015971	NP_057055	Q9Y2R9	RT07_HUMAN	mitochondrial ribosomal protein S7 precursor	212					translation	cytosolic small ribosomal subunit|mitochondrion	protein binding|RNA binding|structural constituent of ribosome			central_nervous_system(1)	1	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			CTGCTGGAGGCTTTCCATAAC	0.577			NA											17	56					0	0	0.010504	0	0
TMEM105	284186	broad.mit.edu	37	17	79287682	79287682	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr17:79287682C>A	uc002kad.1	-	3	709	c.159G>T	c.(157-159)AGG>AGT	p.R53S		NM_178520	NP_848615	Q8N8V8	TM105_HUMAN	transmembrane protein 105	53						integral to membrane				ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.0892)			GGGGAGACGTCCTCGGGCCCT	0.607			NA											35	66					2.87052e-16	4.2068e-16	0.005524	1	0
OSBPL1A	114876	broad.mit.edu	37	18	21898723	21898723	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr18:21898723C>G	uc002kve.2	-	8	850	c.676G>C	c.(676-678)GTT>CTT	p.V226L	OSBPL1A_uc002kvf.3_Missense_Mutation_p.V6L|MIR320C2_hsa-mir-320c-2|MI0008191_5'Flank	NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	226					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					TTATTACCAACAAGAATGTGT	0.284			NA											16	39					0	0	0.004007	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55024510	55024510	+	Missense_Mutation	SNP	G	G	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr18:55024510G>C	uc002lgn.2	+	3	1026	c.669G>C	c.(667-669)TTG>TTC	p.L223F		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	223	Lumenal (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|skin(1)	2				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		ACAATCTCTTGACTATTCAGG	0.423			NA											13	49					0	0	0.013537	0	0
ZNF516	9658	broad.mit.edu	37	18	74154250	74154250	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr18:74154250C>A	uc010dqx.1	-	2	996	c.761G>T	c.(760-762)GGC>GTC	p.G254V	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	254	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GAAGGCCTGGCCACACACCTC	0.682			NA											9	10					1.12685e-05	1.30612e-05	0.004482	1	0
AP3D1	8943	broad.mit.edu	37	19	2114283	2114283	+	Silent	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr19:2114283C>T	uc002luz.2	-	22	2665	c.2442G>A	c.(2440-2442)GAG>GAA	p.E814E	AP3D1_uc010dsv.2_5'Flank|AP3D1_uc002luy.2_Silent_p.E723E|AP3D1_uc002lva.2_Silent_p.E814E	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	814					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TAGGCAGTTTCTCGCTGTCGG	0.537			NA											12	41					0	0	0.00245	0	0
AP3D1	8943	broad.mit.edu	37	19	2115314	2115314	+	Silent	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr19:2115314C>T	uc002luz.2	-	20	2476	c.2253G>A	c.(2251-2253)AAG>AAA	p.K751K	AP3D1_uc002luy.2_Silent_p.K660K|AP3D1_uc002lva.2_Silent_p.K751K	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	751	Potential.				eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTTGCCcttcttctccttct	0.502			NA											13	47					0	0	0.013537	0	0
AP3D1	8943	broad.mit.edu	37	19	2115341	2115341	+	Silent	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr19:2115341C>T	uc002luz.2	-	20	2449	c.2226G>A	c.(2224-2226)AGG>AGA	p.R742R	AP3D1_uc002luy.2_Silent_p.R651R|AP3D1_uc002lva.2_Silent_p.R742R	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	742	Potential.				eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		tctttttcctcctcttgtcct	0.542			NA											9	65					0	0	0.013537	0	0
AP3D1	8943	broad.mit.edu	37	19	2115379	2115379	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr19:2115379C>T	uc002luz.2	-	20	2411	c.2188G>A	c.(2188-2190)GAG>AAG	p.E730K	AP3D1_uc002luy.2_Missense_Mutation_p.E639K|AP3D1_uc002lva.2_Missense_Mutation_p.E730K	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	730	Potential.				eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCCGCCGCTCCTCCTCCAGC	0.557			NA											17	80					0	0	0.014323	0	0
AP3D1	8943	broad.mit.edu	37	19	2115386	2115386	+	Silent	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr19:2115386C>T	uc002luz.2	-	20	2404	c.2181G>A	c.(2179-2181)CTG>CTA	p.L727L	AP3D1_uc002luy.2_Silent_p.L636L|AP3D1_uc002lva.2_Silent_p.L727L	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	727	Potential.				eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTCCTCCTCCAGCTTCACAT	0.557			NA											18	76					0	0	0.00278	0	0
AP3D1	8943	broad.mit.edu	37	19	2120872	2120872	+	Silent	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr19:2120872C>T	uc002luz.2	-	14	1693	c.1470G>A	c.(1468-1470)GGG>GGA	p.G490G	AP3D1_uc002luy.2_Silent_p.G399G|AP3D1_uc002lva.2_Silent_p.G490G	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	490					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGAGAACTCCCCGCAGATCC	0.637			NA											6	36					0	0	0.001984	0	0
MUC16	94025	broad.mit.edu	37	19	9046894	9046894	+	Silent	SNP	A	A	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr19:9046894A>G	uc002mkp.2	-	5	34941	c.34737T>C	c.(34735-34737)ACT>ACC	p.T11579T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11581	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGCAGGATGAGTGAGCCACG	0.522			NA											3	34					0	0	0.004672	0	0
MUC16	94025	broad.mit.edu	37	19	9063968	9063968	+	Silent	SNP	A	A	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr19:9063968A>C	uc002mkp.2	-	3	23682	c.23478T>G	c.(23476-23478)GCT>GCG	p.A7826A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7828	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCAGGGAGGAAGCTAGCTCTG	0.542			NA											10	69					0	0	0.006214	0	0
CDKN2D	1032	broad.mit.edu	37	19	10677830	10677830	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr19:10677830C>G	uc002mpa.2	-	2	707	c.405G>C	c.(403-405)AGG>AGC	p.R135S	KRI1_uc002mox.1_5'Flank|KRI1_uc002moy.1_5'Flank|CDKN2D_uc002mpb.2_Missense_Mutation_p.R135S	NM_001800	NP_001791	P55273	CDN2D_HUMAN	cyclin-dependent kinase inhibitor 2D	135	ANK 3.				anti-apoptosis|autophagic cell death|cell cycle arrest|DNA synthesis involved in DNA repair|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|negative regulation of caspase activity|negative regulation of cell growth|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|response to retinoic acid|response to UV|response to vitamin D	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding				0			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)			CCCTGGCGTCCCTGCGATGGA	0.612			NA							Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System				8	78					0	0	0.004482	0	0
FXYD7	53822	broad.mit.edu	37	19	35642229	35642229	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr19:35642229T>G	uc002nye.1	+	3	218	c.134T>G	c.(133-135)ATC>AGC	p.I45S	FXYD7_uc002nyf.1_Missense_Mutation_p.I45S	NM_022006	NP_071289	P58549	FXYD7_HUMAN	FXYD domain-containing ion transport regulator	45	Helical; (Potential).					integral to membrane	ion channel activity				0	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;2.32e-21)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;2.43e-18)|LUSC - Lung squamous cell carcinoma(66;0.0849)			CTCATCGTCATCAGTAAGTGC	0.542			NA											10	105					0	0	0.013537	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39915029	39915029	+	Missense_Mutation	SNP	G	G	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr19:39915029G>C	uc010xuz.1	+	19	3581	c.3256G>C	c.(3256-3258)GAT>CAT	p.D1086H	PLEKHG2_uc010xuy.1_Missense_Mutation_p.D1027H|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Missense_Mutation_p.D864H	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	1086	Pro-rich.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			AAGCAGCCTGGATCCCCAGGG	0.582			NA											19	45					0	0	0.006122	0	0
FCGBP	8857	broad.mit.edu	37	19	40434113	40434113	+	Nonsense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr19:40434113G>T	uc002omp.3	-	2	164	c.156C>A	c.(154-156)TAC>TAA	p.Y52*		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	52	IgGFc-binding.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGAGGCGGGGGTAGGCCTTGC	0.577			NA											19	65					1.28384e-07	1.56641e-07	0.012319	1	0
ZNF225	7768	broad.mit.edu	37	19	44635941	44635941	+	Nonsense_Mutation	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr19:44635941C>T	uc002oyj.1	+	5	1417	c.1174C>T	c.(1174-1176)CGA>TGA	p.R392*	ZNF225_uc010eje.1_Nonsense_Mutation_p.R309*|ZNF225_uc010ejf.1_Nonsense_Mutation_p.R392*	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	zinc finger protein 225	392	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				AAGACATGTGCGAGTCCACAG	0.428			NA											9	93					0	0	0.008291	0	0
RSPH6A	81492	broad.mit.edu	37	19	46307742	46307742	+	Missense_Mutation	SNP	G	G	A	rs76423334	byFrequency	TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr19:46307742G>A	uc002pdm.2	-	3	1564	c.1421C>T	c.(1420-1422)CCG>CTG	p.P474L	RSPH6A_uc002pdl.2_Missense_Mutation_p.P210L	NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	radial spokehead-like 1	474						intracellular				ovary(1)|central_nervous_system(1)	2						CTCGTTGCCCGGGAAGGGTGG	0.632			NA											4	53					0	0	0.000602	0	0
ZNF813	126017	broad.mit.edu	37	19	53995018	53995018	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr19:53995018C>T	uc002qbu.2	+	4	1660	c.1532C>T	c.(1531-1533)GCA>GTA	p.A511V	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	511	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		ACACACCTTGCATGTCATCAT	0.388			NA											3	37					0	0	0.004672	0	0
ZNF551	90233	broad.mit.edu	37	19	58196753	58196753	+	Missense_Mutation	SNP	G	G	T	rs142211450	by1000genomes	TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr19:58196753G>T	uc002qpw.3	+	2	380	c.157G>T	c.(157-159)GGT>TGT	p.G53C	ZNF551_uc002qpv.3_Intron|ZNF776_uc002qpx.2_Intron	NM_138347	NP_612356	Q7Z340	ZN551_HUMAN	zinc finger protein 551	69	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AACATCCCTGGGTAAGGCCCT	0.478			NA											22	175					6.32553e-13	8.91166e-13	0.004656	1	0
C19orf18	147685	broad.mit.edu	37	19	58472789	58472789	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr19:58472789C>T	uc002qqv.2	-	5	606	c.502G>A	c.(502-504)GAA>AAA	p.E168K		NM_152474	NP_689687	Q8NEA5	CS018_HUMAN	hypothetical protein LOC147685 precursor	168	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)		AGCTCATTTTCGTTCTCTGGA	0.488			NA											4	69					0	0	0.000602	0	0
ZNF638	27332	broad.mit.edu	37	2	71629097	71629097	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr2:71629097A>C	uc002shx.2	+	16	3028	c.2709A>C	c.(2707-2709)GAA>GAC	p.E903D	ZNF638_uc010yqw.1_Missense_Mutation_p.E482D|ZNF638_uc002shy.2_Missense_Mutation_p.E903D|ZNF638_uc002shz.2_Missense_Mutation_p.E903D|ZNF638_uc002sia.2_Missense_Mutation_p.E903D|ZNF638_uc002sib.1_Missense_Mutation_p.E903D|ZNF638_uc010fed.2_RNA|ZNF638_uc002sic.2_5'UTR	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	903					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						AAACAGAAGAAATGTGTGTGA	0.269			NA											5	58					0	0	0.000602	0	0
C2orf51	200523	broad.mit.edu	37	2	88828809	88828809	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr2:88828809G>T	uc002stb.1	+	4	502	c.360G>T	c.(358-360)CAG>CAT	p.Q120H		NM_152670	NP_689883	Q96LM6	TSC21_HUMAN	chromosome 2 open reading frame 51	120						nucleus				skin(1)	1						ACCTGGCCCAGGGTGACCCCA	0.592			NA											23	64					6.44725e-10	8.47448e-10	0.014323	1	0
C2orf51	200523	broad.mit.edu	37	2	88828903	88828903	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr2:88828903C>A	uc002stb.1	+	4	596	c.454C>A	c.(454-456)CTA>ATA	p.L152I		NM_152670	NP_689883	Q96LM6	TSC21_HUMAN	chromosome 2 open reading frame 51	152						nucleus				skin(1)	1						AGGCTACCTGCTACTGCCAGG	0.562			NA											23	49					1.10923e-09	1.44313e-09	0.00278	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125530567	125530567	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr2:125530567C>A	uc002tno.2	+	17	3086	c.2722C>A	c.(2722-2724)CTG>ATG	p.L908M	CNTNAP5_uc010flu.2_Missense_Mutation_p.L909M	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	908	Laminin G-like 3.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CCATTTTCGACTGCAGCTGAA	0.532			NA											38	81					3.09479e-21	4.78285e-21	0.006999	1	0
NCKAP5	344148	broad.mit.edu	37	2	133543111	133543111	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr2:133543111C>T	uc002ttp.2	-	14	1647	c.1273G>A	c.(1273-1275)GGT>AGT	p.G425S	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	425							protein binding				0						TCTTTATAACCCCATTTGGTT	0.438			NA											5	81					0	0	0.001168	0	0
PDK1	5163	broad.mit.edu	37	2	173435514	173435514	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr2:173435514G>A	uc002uhr.2	+	8	1007	c.907G>A	c.(907-909)GTT>ATT	p.V303I	PDK1_uc010zdz.1_Missense_Mutation_p.V148I|PDK1_uc010zea.1_RNA|PDK1_uc002uhq.1_Missense_Mutation_p.V323I|PDK1_uc002uhs.2_Missense_Mutation_p.V303I|PDK1_uc010zeb.1_Missense_Mutation_p.V323I	NM_002610	NP_002601	Q15118	PDK1_HUMAN	pyruvate dehydrogenase kinase 1 precursor	303	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|small GTPase mediated signal transduction	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			lung(3)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.12)			CCCTATTCAAGTTCATGTCAC	0.353			NA							Autosomal_Dominant_Polycystic_Kidney_Disease				20	48					0	0	0.00333	0	0
DNAH7	56171	broad.mit.edu	37	2	196825586	196825586	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr2:196825586C>A	uc002utj.3	-	18	2390	c.2289G>T	c.(2287-2289)TTG>TTT	p.L763F		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	763	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GATAAGGGTTCAAGCCATCTT	0.393			NA											7	133					2.7689e-08	3.44424e-08	0.001984	1	0
MDH1B	130752	broad.mit.edu	37	2	207615733	207615733	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr2:207615733C>A	uc002vbs.2	-	6	1032	c.977G>T	c.(976-978)AGG>ATG	p.R326M	MDH1B_uc010ziw.1_Intron|MDH1B_uc010fui.2_Missense_Mutation_p.R326M|MDH1B_uc010fuj.2_Missense_Mutation_p.R228M|MDH1B_uc002vbt.2_Intron	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	326					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		TCTGTACACCCTTGTTTTTCT	0.338	Pancreas(76;29 1355 28675 37177 51207)		NA											11	97					5.50884e-06	6.47352e-06	0.013537	1	0
C2orf80	389073	broad.mit.edu	37	2	209049756	209049757	+	Splice_Site	DNP	CC	CC	AA			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr2:209049756_209049757CC>AA	uc002vcr.2	-	3	214	c.42_splice	c.e3-1	p.L14_splice		NM_001099334	NP_001092804	Q0P641	CB080_HUMAN	hypothetical protein LOC389073											skin(1)	1						TATAATCTCCCCTTAAAAGCAA	0.446			NA											9	61					0	0	0.004672	0	0
IKZF2	22807	broad.mit.edu	37	2	213872367	213872367	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr2:213872367C>A	uc002vem.2	-	8	1467	c.1298G>T	c.(1297-1299)AGC>ATC	p.S433I	IKZF2_uc010fuu.2_Missense_Mutation_p.S288I|IKZF2_uc002vej.2_Missense_Mutation_p.S380I|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Missense_Mutation_p.S359I|IKZF2_uc002vel.2_Missense_Mutation_p.S354I|IKZF2_uc010fuw.2_Missense_Mutation_p.S207I|IKZF2_uc010fux.2_Missense_Mutation_p.S207I|IKZF2_uc010fuy.2_Missense_Mutation_p.S361I|IKZF2_uc002ven.2_Missense_Mutation_p.S407I|IKZF2_uc002vei.2_Missense_Mutation_p.S211I	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	433					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		GTAAGCTGGGCTTTGTTTCCT	0.493			NA											25	273					3.28513e-13	4.65393e-13	0.003954	1	0
ANO7	50636	broad.mit.edu	37	2	242149890	242149890	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr2:242149890G>A	uc002wax.2	+	15	1731	c.1628G>A	c.(1627-1629)CGC>CAC	p.R543H		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	543	Extracellular (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						TAGGCCTCTCGCATCGCCAGC	0.642			NA											5	45					0	0	0.001168	0	0
PROKR2	128674	broad.mit.edu	37	20	5294904	5294904	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr20:5294904C>T	uc010zqw.1	-	1	112	c.112G>A	c.(112-114)GAT>AAT	p.D38N	PROKR2_uc010zqx.1_Missense_Mutation_p.D38N|PROKR2_uc010zqy.1_Missense_Mutation_p.D38N|uc002wly.1_5'Flank	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	38	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						TCATCCTCATCCATAGGGAGG	0.507			NA								HNSCC(71;0.22)			15	82					0	0	0.004007	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47630484	47630484	+	Missense_Mutation	SNP	A	A	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr20:47630484A>T	uc002xtx.3	+	30	4318	c.4166A>T	c.(4165-4167)GAG>GTG	p.E1389V	ARFGEF2_uc010zyf.1_Missense_Mutation_p.E682V	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1389					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			AAACTCCCTGAGCAACTGTCA	0.483	Esophageal Squamous(176;1738 1974 26285 33069 35354)		NA											19	106					0	0	0.008871	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871354	51871354	+	Missense_Mutation	SNP	T	T	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr20:51871354T>A	uc002xwo.2	+	2	2313	c.1357T>A	c.(1357-1359)TGT>AGT	p.C453S		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	453					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			AGCATCAGATTGTACAGCCTC	0.458			NA											31	94					0	0	0.008361	0	0
ZNF217	7764	broad.mit.edu	37	20	52193560	52193560	+	Silent	SNP	A	A	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr20:52193560A>G	uc002xwq.3	-	3	2014	c.1743T>C	c.(1741-1743)TCT>TCC	p.S581S	ZNF217_uc010gij.1_Silent_p.S573S	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	581					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			TCTGAAAAACAGAAGGCATCT	0.443			NA											41	76					0	0	0.00623	0	0
CASS4	57091	broad.mit.edu	37	20	55012553	55012553	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr20:55012553C>A	uc002xxp.2	+	3	595	c.370C>A	c.(370-372)CAG>AAG	p.Q124K	CASS4_uc002xxq.3_Missense_Mutation_p.Q124K|CASS4_uc002xxr.2_Missense_Mutation_p.Q124K|CASS4_uc010zze.1_Intron|CASS4_uc010gio.2_Missense_Mutation_p.Q124K	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	124					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						GGAGGGGCCCCAGCCCCCTAC	0.582			NA											23	90					5.35356e-11	7.33956e-11	0.00278	1	0
SLMO2	51012	broad.mit.edu	37	20	57613683	57613683	+	Silent	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr20:57613683C>A	uc002yam.2	-	2	155	c.39G>T	c.(37-39)CCG>CCT	p.P13P	SLMO2_uc010zzv.1_Silent_p.P13P	NM_016045	NP_057129	Q9Y3B1	SLMO2_HUMAN	slowmo homolog 2	13	PRELI/MSF1.									skin(1)	1	all_lung(29;0.00711)		Colorectal(105;0.109)			CAGTTTCCCACGGGTGGCTGC	0.358			NA											22	90					8.10497e-08	9.98439e-08	0.010504	1	0
TPTE	7179	broad.mit.edu	37	21	10941911	10941911	+	Silent	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr21:10941911G>T	uc002yip.1	-	14	1160	c.792C>A	c.(790-792)ATC>ATA	p.I264I	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Silent_p.I246I|TPTE_uc002yir.1_Silent_p.I226I|TPTE_uc010gkv.1_Silent_p.I126I	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	264	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CCCTTACCTTGATTGGATTTC	0.313			NA											37	184					1.90571e-15	2.77689e-15	0.004289	1	0
BAGE2	85319	broad.mit.edu	37	21	11097584	11097584	+	Silent	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr21:11097584C>A	uc002yit.1	-	2	286	c.78G>T	c.(76-78)GTG>GTT	p.V26V	BAGE_uc002yix.2_RNA	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		tccagctcaccacaggggact	0.119			NA											4	61					0.00909568	0.00954485	0.009096	1	0
ADAMTS5	11096	broad.mit.edu	37	21	28327084	28327084	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr21:28327084G>T	uc002ymg.2	-	2	1940	c.1211C>A	c.(1210-1212)GCA>GAA	p.A404E		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	404	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						AGTGAAGGCTGCGTGGAGGCC	0.502	Esophageal Squamous(53;683 1080 10100 14424 45938)		NA											12	59					6.72482e-11	9.12144e-11	0.003163	1	0
KRTAP24-1	643803	broad.mit.edu	37	21	31654799	31654799	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr21:31654799C>G	uc002ynv.2	-	1	478	c.452G>C	c.(451-453)TGC>TCC	p.C151S		NM_001085455	NP_001078924	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	151						keratin filament	structural molecule activity				0						TTGTCCAAAGCAGTTGGAACC	0.388			NA											49	98					0	0	0.01441	0	0
KRTAP10-6	386674	broad.mit.edu	37	21	46012274	46012274	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr21:46012274G>T	uc002zfm.2	-	1	113	c.92C>A	c.(91-93)TCC>TAC	p.S31Y	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198688	NP_941961	P60371	KR106_HUMAN	keratin associated protein 10-6	31						keratin filament					0						CACCTGCCAGGAGTCGGAGCA	0.682			NA											5	27					8.12818e-05	9.21194e-05	0.001984	1	0
ADARB1	104	broad.mit.edu	37	21	46604837	46604837	+	Splice_Site	SNP	G	G	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr21:46604837G>C	uc002zgy.2	+	9	1952	c.1517_splice	c.e9-1	p.E506_splice	ADARB1_uc002zgr.2_Splice_Site_p.E506_splice|ADARB1_uc002zgs.2_Splice_Site|ADARB1_uc002zgw.2_Splice_Site_p.E466_splice|ADARB1_uc002zgv.2_Splice_Site|ADARB1_uc002zgt.2_Splice_Site_p.E466_splice|ADARB1_uc010gpx.2_Splice_Site|ADARB1_uc002zgq.2_Splice_Site|ADARB1_uc002zgu.2_Splice_Site	NM_015833	NP_056648	P78563	RED1_HUMAN	RNA-specific adenosine deaminase B1 isoform 2						adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			skin(1)	1				Colorectal(79;0.115)		TTCTCTCTTAGAACCAGCAGA	0.398			NA											10	116					0	0	0.008291	0	0
SCN10A	6336	broad.mit.edu	37	3	38770309	38770309	+	Silent	SNP	C	C	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr3:38770309C>G	uc003ciq.2	-	15	2364	c.2364G>C	c.(2362-2364)GGG>GGC	p.G788G		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	788	II.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGGTGAGGTTCCCCAGTGCCC	0.502			NA											5	50					0	0	0.000602	0	0
COL7A1	1294	broad.mit.edu	37	3	48630019	48630019	+	Missense_Mutation	SNP	G	G	T	rs141801873		TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr3:48630019G>T	uc003ctz.2	-	7	961	c.960C>A	c.(958-960)AGC>AGA	p.S320R		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	320	Nonhelical region (NC1).|Fibronectin type-III 1.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GAGCTGTCCCGCTCACAGCCT	0.617			NA											9	30					0.000274275	0.000306755	0.004482	1	0
RNF123	63891	broad.mit.edu	37	3	49744330	49744330	+	Missense_Mutation	SNP	A	A	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr3:49744330A>T	uc003cxh.2	+	26	2581	c.2495A>T	c.(2494-2496)CAG>CTG	p.Q832L	RNF123_uc010hky.1_Missense_Mutation_p.Q494L|RNF123_uc003cxi.2_RNA	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	832						cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		GTCTACTCCCAGGTGTGCTGG	0.597			NA											13	29					0	0	0.013537	0	0
PROS1	5627	broad.mit.edu	37	3	93593234	93593234	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr3:93593234G>A	uc003drb.3	-	15	2227	c.1886C>T	c.(1885-1887)GCC>GTC	p.A629V	PROS1_uc010hoo.2_Missense_Mutation_p.A498V|PROS1_uc003dqz.3_Missense_Mutation_p.A498V	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	629	Laminin G-like 2.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	CACTGGTGTGGCACTGAATGG	0.353			NA											5	49					0	0	0.000602	0	0
HCLS1	3059	broad.mit.edu	37	3	121356023	121356023	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr3:121356023C>G	uc003eeh.3	-	7	660	c.535G>C	c.(535-537)GGA>CGA	p.G179R	HCLS1_uc011bjj.1_Intron|HCLS1_uc011bjk.1_RNA	NM_005335	NP_005326	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	179	Cortactin 3.				erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(114;0.0912)		TCCGTCTCTCCCTTGTAGTCA	0.542			NA											18	33					0	0	0.008871	0	0
GOLGB1	2804	broad.mit.edu	37	3	121413585	121413585	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr3:121413585C>A	uc003eei.3	-	13	5896	c.5770G>T	c.(5770-5772)GAG>TAG	p.E1924*	GOLGB1_uc010hrc.2_Nonsense_Mutation_p.E1929*|GOLGB1_uc003eej.3_Nonsense_Mutation_p.E1890*|GOLGB1_uc011bjm.1_Nonsense_Mutation_p.E1810*|GOLGB1_uc010hrd.1_Nonsense_Mutation_p.E1888*	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1924	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		ATAAGCCTCTCTTCCAAATCA	0.368			NA											56	126					1.54886e-18	2.33704e-18	0.01441	1	0
KALRN	8997	broad.mit.edu	37	3	124377365	124377365	+	Splice_Site	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr3:124377365G>A	uc003ehg.2	+	42	6247	c.6120_splice	c.e42+1	p.E2040_splice	KALRN_uc003ehi.2_Splice_Site_p.E381_splice|KALRN_uc003ehk.2_Splice_Site_p.E343_splice|KALRN_uc011bjz.1_Splice_Site_p.E132_splice	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CTACTTTGAGGTAAGCTGTGC	0.507			NA											12	50					0	0	0.010729	0	0
SRPRB	58477	broad.mit.edu	37	3	133525539	133525539	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr3:133525539T>G	uc003epx.1	+	2	257	c.241T>G	c.(241-243)TTT>GTT	p.F81V		NM_021203	NP_067026	Q9Y5M8	SRPRB_HUMAN	signal recognition particle receptor, beta	81						endoplasmic reticulum membrane|integral to membrane	GTP binding|protein binding|receptor activity			ovary(1)	1						AACGTTGCTCTTTGTCAGGGT	0.403			NA											5	75					0	0	0.001168	0	0
CLDN18	51208	broad.mit.edu	37	3	137742593	137742593	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr3:137742593G>A	uc003ero.1	+	2	367	c.314G>A	c.(313-315)CGC>CAC	p.R105H	CLDN18_uc003erp.1_Missense_Mutation_p.R105H|CLDN18_uc010hue.1_Silent_p.P100P	NM_001002026	NP_001002026	P56856	CLD18_HUMAN	claudin 18 isoform 2	105	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			upper_aerodigestive_tract(1)|ovary(1)	2						AAATGCATCCGCATTGGCAGC	0.557			NA											17	41					0	0	0.00499	0	0
RSRC1	51319	broad.mit.edu	37	3	158261251	158261251	+	Missense_Mutation	SNP	A	A	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr3:158261251A>G	uc003fbt.2	+	9	998	c.887A>G	c.(886-888)GAT>GGT	p.D296G	RSRC1_uc003fbv.2_Missense_Mutation_p.D238G	NM_016625	NP_057709	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	296					nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding				0			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			AAGTACCAAGATGACAATTCC	0.388			NA											28	117					0	0	0.010818	0	0
MECOM	2122	broad.mit.edu	37	3	168840508	168840508	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr3:168840508T>C	uc003ffi.3	-	5	543	c.274A>G	c.(274-276)AAA>GAA	p.K92E	MECOM_uc010hwk.1_Missense_Mutation_p.K115E|MECOM_uc003ffj.3_Missense_Mutation_p.K156E|MECOM_uc011bpi.1_Missense_Mutation_p.K92E|MECOM_uc003ffn.3_Missense_Mutation_p.K92E|MECOM_uc003ffk.2_Missense_Mutation_p.K92E|MECOM_uc003ffl.2_Missense_Mutation_p.K252E|MECOM_uc011bpj.1_Missense_Mutation_p.K280E|MECOM_uc011bpk.1_Missense_Mutation_p.K82E|MECOM_uc010hwn.2_Missense_Mutation_p.K280E|MECOM_uc003ffm.1_Missense_Mutation_p.K156E	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	92	Interaction with MAPK9, SMAD3 and probably SUV39H1.|C2H2-type 2.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						AGCATGTGTTTCTCCAGGCTG	0.368			NA											6	71					0	0	0.001984	0	0
KLHL24	54800	broad.mit.edu	37	3	183397003	183397003	+	Missense_Mutation	SNP	A	A	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr3:183397003A>G	uc003flv.2	+	8	2027	c.1732A>G	c.(1732-1734)ATG>GTG	p.M578V	KLHL24_uc003flw.2_Missense_Mutation_p.M578V	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	578	Kelch 6.					axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			GGTAGCTGCAATGCCCAGGCC	0.443			NA											28	62					0	0	0.008361	0	0
NCBP2	22916	broad.mit.edu	37	3	196664485	196664485	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr3:196664485G>A	uc003fxd.1	-	3	385	c.295C>T	c.(295-297)CGG>TGG	p.R99W	NCBP2_uc003fxb.1_Missense_Mutation_p.R29W|NCBP2_uc011btz.1_Missense_Mutation_p.R81W|NCBP2_uc003fxc.1_RNA|NCBP2_uc003fxe.1_Missense_Mutation_p.R46W|NCBP2_uc003fxf.2_3'UTR	NM_007362	NP_031388	P52298	NCBP2_HUMAN	nuclear cap binding protein subunit 2, 20kDa	99	RRM.				gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of RNA export from nucleus|positive regulation of viral transcription|regulation of translational initiation|snRNA export from nucleus|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm	nucleotide binding|protein binding|RNA 7-methylguanosine cap binding				0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.42e-24)|all cancers(36;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(49;4.13e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00551)		TTTATGTACCGCATGGCGTTT	0.488			NA											4	94					0	0	0.000602	0	0
UGT2B7	7364	broad.mit.edu	37	4	69978338	69978338	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr4:69978338G>A	uc003heg.3	+	6	1520	c.1474G>A	c.(1474-1476)GAT>AAT	p.D492N	UGT2B7_uc010ihq.2_3'UTR	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	492					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						CCACTCTTTGGATGTGATTGG	0.458			NA											17	138					0	0	0.00499	0	0
BANK1	55024	broad.mit.edu	37	4	102839313	102839313	+	Silent	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr4:102839313C>T	uc003hvy.3	+	7	1447	c.1173C>T	c.(1171-1173)CAC>CAT	p.H391H	BANK1_uc003hvx.3_Silent_p.H376H|BANK1_uc010ill.2_Silent_p.H258H|BANK1_uc003hvz.3_Silent_p.H361H	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	391	ANK 2.				B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		GGCATGGTCACAAAGAACTCA	0.358			NA											7	74					0	0	0.001984	0	0
TACR3	6870	broad.mit.edu	37	4	104512654	104512654	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr4:104512654G>T	uc003hxe.1	-	4	1218	c.1075C>A	c.(1075-1077)CTG>ATG	p.L359M		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	359	Helical; Name=7; (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		CTTTTATTCAGACAGCAGTAG	0.398			NA											22	71					2.89027e-11	4.00553e-11	0.014323	1	0
CYP2U1	113612	broad.mit.edu	37	4	108868619	108868619	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr4:108868619C>A	uc003hyp.2	+	3	1297	c.1214C>A	c.(1213-1215)GCC>GAC	p.A405D	CYP2U1_uc011cfi.1_Missense_Mutation_p.A196D	NM_183075	NP_898898	Q7Z449	CP2U1_HUMAN	cytochrome P450, family 2, subfamily U,	405					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000128)		TACACAGAAGCCACCATCATG	0.498			NA											19	41					8.00594e-06	9.36475e-06	0.007413	1	0
ODZ3	55714	broad.mit.edu	37	4	183675836	183675836	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr4:183675836C>T	uc003ivd.1	+	21	4353	c.4316C>T	c.(4315-4317)TCC>TTC	p.S1439F	ODZ3_uc003ive.1_Missense_Mutation_p.S852F	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1439	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		GGAGAAATCTCCTTAGTGGCC	0.468			NA											8	34					0	0	0.00308	0	0
CDH12	1010	broad.mit.edu	37	5	21975427	21975427	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr5:21975427G>A	uc010iuc.2	-	3	757	c.299C>T	c.(298-300)ACC>ATC	p.T100I	CDH12_uc011cno.1_Missense_Mutation_p.T100I|CDH12_uc003jgk.2_Missense_Mutation_p.T100I	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	100	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						GGTAAAAACGGTGCCAGCGCC	0.433			NA								HNSCC(59;0.17)			44	112					0	0	0.01441	0	0
CCNB1	891	broad.mit.edu	37	5	68467140	68467140	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr5:68467140C>A	uc003jvm.2	+	4	584	c.407C>A	c.(406-408)GCC>GAC	p.A136D	CCNB1_uc011crd.1_Missense_Mutation_p.A136D|CCNB1_uc010ixb.2_Missense_Mutation_p.A136D	NM_031966	NP_114172	P14635	CCNB1_HUMAN	cyclin B1	136					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle spindle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|mitotic spindle stabilization|positive regulation of attachment of spindle microtubules to kinetochore|positive regulation of mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	condensed nuclear chromosome outer kinetochore|cytosol|microtubule organizing center|nucleoplasm|spindle pole					0		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		TCTGGATGTGCCCCTGCAGAA	0.423			NA											7	88					8.12818e-05	9.21194e-05	0.001984	1	0
CMYA5	202333	broad.mit.edu	37	5	79030937	79030937	+	Missense_Mutation	SNP	G	G	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr5:79030937G>C	uc003kgc.2	+	2	6421	c.6349G>C	c.(6349-6351)GAT>CAT	p.D2117H		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2117						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TGATGATGCTGATGAGGGAAA	0.438			NA											20	49					0	0	0.008871	0	0
ATG10	83734	broad.mit.edu	37	5	81460256	81460256	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr5:81460256T>G	uc003khs.2	+	5	684	c.255T>G	c.(253-255)ATT>ATG	p.I85M	ATG10_uc003khr.2_Missense_Mutation_p.I85M|ATG10_uc010jas.2_Missense_Mutation_p.I49M	NM_001131028	NP_001124500	Q9H0Y0	ATG10_HUMAN	APG10 autophagy 10-like	85					autophagy in response to ER overload|positive regulation of protein modification process|protein lipidation|protein modification by small protein conjugation|protein transport	cytoplasm	Atg12 ligase activity|protein binding				0		Lung NSC(167;0.0258)|all_lung(232;0.0294)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;9.94e-41)|Epithelial(54;6.3e-36)|all cancers(79;2.31e-30)		GTGAAGTGATTGAAACTGCAG	0.378			NA											49	85					0	0	0.01441	0	0
FBN2	2201	broad.mit.edu	37	5	127599195	127599195	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr5:127599195G>T	uc003kuu.2	-	63	8553	c.8114C>A	c.(8113-8115)CCC>CAC	p.P2705H		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2705	EGF-like 47; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GTAATTGCAGGGGTTCTTGGA	0.612			NA											19	132					1.00905e-13	1.43747e-13	0.008871	1	0
PCDHA8	56140	broad.mit.edu	37	5	140222229	140222229	+	Silent	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr5:140222229G>A	uc003lhs.2	+	1	1323	c.1323G>A	c.(1321-1323)TTG>TTA	p.L441L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.L441L	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	441	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCCAGCTTGTCTGTGGAGG	0.662			NA											6	89					0	0	0.001984	0	0
PCDHB6	56130	broad.mit.edu	37	5	140529991	140529991	+	Silent	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr5:140529991G>A	uc003lir.2	+	1	153	c.153G>A	c.(151-153)CTG>CTA	p.L51L	PCDHB6_uc011dah.1_Intron	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	51	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAAAGGACCTGGGACTGAGGG	0.512			NA											32	120					0	0	0.008361	0	0
PCDHB17	54661	broad.mit.edu	37	5	140536921	140536921	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr5:140536921G>A	uc003lis.2	+	1	1342	c.1342G>A	c.(1342-1344)GCC>ACC	p.A448T		NR_001280				SubName: Full=Protocadherin-psi1;												0						CAATGACAACGCCCCCGCCTT	0.587			NA											5	91					0	0	0.001984	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573077	140573077	+	Missense_Mutation	SNP	A	A	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr5:140573077A>T	uc003lix.2	+	1	1126	c.952A>T	c.(952-954)AAT>TAT	p.N318Y		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	318	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTACAAAATAAATATACAGGC	0.378			NA											7	156					0	0	0.00308	0	0
PCDHB12	56124	broad.mit.edu	37	5	140590351	140590351	+	Silent	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr5:140590351G>A	uc003liz.2	+	1	2061	c.1872G>A	c.(1870-1872)GTG>GTA	p.V624V	PCDHB12_uc011dak.1_Silent_p.V287V	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	624	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATGGCGAGGTGCGCACCGCCA	0.706			NA											5	91					0	0	0.00308	0	0
FAT2	2196	broad.mit.edu	37	5	150943179	150943179	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr5:150943179G>T	uc003lue.3	-	2	3294	c.3281C>A	c.(3280-3282)CCC>CAC	p.P1094H	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.P1094H	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1094	Cadherin 9.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCGGTCCAGGGGTGCCAGAGT	0.473			NA											4	44					1.23904e-05	1.42966e-05	0.000602	1	0
EBF1	1879	broad.mit.edu	37	5	158223455	158223455	+	Silent	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr5:158223455C>T	uc010jip.2	-	9	1109	c.807G>A	c.(805-807)CCG>CCA	p.P269P	EBF1_uc011ddw.1_Silent_p.P137P|EBF1_uc011ddx.1_Silent_p.P270P|EBF1_uc003lxl.3_Silent_p.P238P	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	269	IPT/TIG.				multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATCCTTCACTCGGGCTGATGG	0.463			NA	T	HMGA2	lipoma								4	66					0	0	0.009096	0	0
NQO2	4835	broad.mit.edu	37	6	3006783	3006783	+	Translation_Start_Site	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr6:3006783C>T	uc003mus.2	+	2	335	c.-3C>T	c.(-5--1)TACGC>TATGC		NQO2_uc003mup.1_Translation_Start_Site|NQO2_uc003mut.2_Translation_Start_Site	NM_000904	NP_000895	P16083	NQO2_HUMAN	NAD(P)H dehydrogenase, quinone 2							cytoplasm|nucleus	coenzyme binding|dihydronicotinamide riboside quinone reductase activity|electron carrier activity|metal ion binding|NADPH dehydrogenase (quinone) activity			ovary(1)	1	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Menadione(DB00170)|NADH(DB00157)	CACCTTCTTACGCTATGGCAG	0.333			NA											3	15					0	0	0.009096	0	0
RPP40	10799	broad.mit.edu	37	6	5000118	5000118	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr6:5000118C>A	uc003mwl.2	-	4	393	c.358G>T	c.(358-360)GAT>TAT	p.D120Y	RPP40_uc003mwm.2_Missense_Mutation_p.D97Y	NM_006638	NP_006629	O75818	RPP40_HUMAN	ribonuclease P 40kDa subunit	120					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0895)				GTGTCTTTATCCAGTGACAAA	0.333			NA											55	67					1.13205e-32	1.82704e-32	0.01441	1	0
SCAND3	114821	broad.mit.edu	37	6	28542849	28542849	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr6:28542849G>T	uc003nlo.2	-	3	2251	c.1633C>A	c.(1633-1635)CAT>AAT	p.H545N		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	545	Potential.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTTTCTGTATGCAAGCTGGCA	0.403			NA											10	99					0.00621372	0.0066297	0.006214	1	0
HSPA1L	3305	broad.mit.edu	37	6	31779552	31779552	+	Silent	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr6:31779552C>T	uc003nxh.2	-	2	381	c.198G>A	c.(196-198)CAG>CAA	p.Q66Q	HSPA1L_uc010jte.2_Silent_p.Q66Q	NM_005527	NP_005518	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	66					response to unfolded protein		ATP binding			ovary(3)|pleura(1)|kidney(1)|skin(1)	6						AAACAGTGTTCTGGGGATTCA	0.493			NA											84	63					0	0	0.01441	0	0
TNXB	7148	broad.mit.edu	37	6	32011892	32011893	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr6:32011892_32011893GG>TT	uc003nzl.2	-	34	11473_11474	c.11271_11272CC>AA	c.(11269-11274)CCCCGT>CCAAGT	p.R3758S	TNXB_uc003nzg.1_Missense_Mutation_p.R189S|TNXB_uc003nzh.1_Missense_Mutation_p.R227S	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3805	Fibronectin type-III 30.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TGGAGGTCACGGGGGCTCTCCA	0.619			NA											6	4					0	0	0.004672	0	0
NOTCH4	4855	broad.mit.edu	37	6	32184793	32184794	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr6:32184793_32184794GG>TT	uc003obb.2	-	11	1928_1929	c.1789_1790CC>AA	c.(1789-1791)CCA>AAA	p.P597K	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc003obc.2_Missense_Mutation_p.P597K	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	597	EGF-like 15; calcium-binding (Potential).|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						AACGGGACATGGGTCACTCAGG	0.584			NA											29	29					0	0	0.004672	0	0
C6orf127	340204	broad.mit.edu	37	6	35755685	35755685	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr6:35755685C>A	uc003old.3	+	3	321	c.264C>A	c.(262-264)AAC>AAA	p.N88K		NM_001010886	NP_001010886	A2RUU4	CF127_HUMAN	hypothetical protein LOC340204 precursor	88					digestion|lipid catabolic process	extracellular region	enzyme activator activity			skin(1)	1						GCCTGCGGAACCTGACTTGTA	0.483			NA											33	58					4.31634e-10	5.73263e-10	0.012213	1	0
TBC1D22B	55633	broad.mit.edu	37	6	37250728	37250728	+	Silent	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr6:37250728G>A	uc003onn.2	+	5	818	c.672G>A	c.(670-672)TCG>TCA	p.S224S	TBC1D22B_uc010jwt.2_RNA	NM_017772	NP_060242	Q9NU19	TB22B_HUMAN	TBC1 domain family, member 22B	224	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0			OV - Ovarian serous cystadenocarcinoma(102;0.241)			GACTCCTGTCGGTGAGTTCTA	0.483			NA											9	21					0	0	0.004482	0	0
HTR1E	3354	broad.mit.edu	37	6	87726029	87726029	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr6:87726029C>A	uc003pli.2	+	2	1680	c.977C>A	c.(976-978)GCC>GAC	p.A326D		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	326	Helical; Name=7; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	TCGGAAGTGGCCGACTTTCTG	0.448			NA											59	83					6.26901e-30	1.00541e-29	0.01441	1	0
CASP8AP2	9994	broad.mit.edu	37	6	90556331	90556331	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr6:90556331G>T	uc003pnr.2	+	2	219	c.23G>T	c.(22-24)GGT>GTT	p.G8V	CASP8AP2_uc003pns.2_Missense_Mutation_p.G8V|CASP8AP2_uc003pnt.2_Missense_Mutation_p.G8V|CASP8AP2_uc011dzz.1_Missense_Mutation_p.G8V	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	8					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		GATGACAATGGTGATGGAACA	0.264	Colon(187;1656 2025 17045 31481 39901)		NA											7	10					1.76689e-08	2.20862e-08	0.006214	1	0
BACH2	60468	broad.mit.edu	37	6	90660894	90660894	+	Missense_Mutation	SNP	G	G	A	rs148083597	byFrequency	TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr6:90660894G>A	uc011eab.1	-	7	1740	c.931C>T	c.(931-933)CGG>TGG	p.R311W	BACH2_uc003pnw.2_Missense_Mutation_p.R311W|BACH2_uc010kch.2_Missense_Mutation_p.R311W	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	311						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		GGCTGTTTCCGGTCCATCTCG	0.647			NA											6	36					0	0	0.001168	0	0
EPHA7	2045	broad.mit.edu	37	6	94066483	94066483	+	Silent	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr6:94066483G>T	uc003poe.2	-	5	1517	c.1276C>A	c.(1276-1278)CGA>AGA	p.R426R	EPHA7_uc003pof.2_Silent_p.R426R|EPHA7_uc011eac.1_Silent_p.R426R	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	426	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity	p.R426*(1)		lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CTCTGGGATCGGCTTAAGTCA	0.418			NA											27	29					3.80469e-20	5.77498e-20	0.009535	1	0
SYNE1	23345	broad.mit.edu	37	6	152804280	152804280	+	Silent	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr6:152804280G>T	uc010kiw.2	-	14	1892	c.1290C>A	c.(1288-1290)ACC>ACA	p.T430T	SYNE1_uc003qot.3_Silent_p.T437T|SYNE1_uc003qou.3_Silent_p.T430T|SYNE1_uc010kjb.1_Silent_p.T413T|SYNE1_uc003qpa.1_Silent_p.T430T|SYNE1_uc003qox.1_5'UTR	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	430	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCTGTTGAACGGTTATTTCCT	0.483			NA								HNSCC(10;0.0054)			78	97					1.1397e-45	1.875e-45	0.01441	1	0
SDK1	221935	broad.mit.edu	37	7	3991446	3991446	+	Silent	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr7:3991446C>T	uc003smx.2	+	7	1183	c.1044C>T	c.(1042-1044)ACC>ACT	p.T348T		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	348	Ig-like C2-type 3.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GACGCCTCACCATCAGCAACC	0.617			NA											8	97					0	0	0.00308	0	0
AOAH	313	broad.mit.edu	37	7	36763656	36763656	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr7:36763656G>T	uc003tfh.3	-	1	499	c.98C>A	c.(97-99)CCC>CAC	p.P33H	AOAH_uc010kxf.2_Missense_Mutation_p.P33H|AOAH_uc011kba.1_Missense_Mutation_p.P33H	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	33					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						CGAGAGGCTGGGCCTGGACTG	0.483			NA											20	33					1.2644e-06	1.50665e-06	0.010504	1	0
ABCA13	154664	broad.mit.edu	37	7	48413973	48413973	+	Missense_Mutation	SNP	A	A	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr7:48413973A>T	uc003toq.2	+	34	11188	c.11163A>T	c.(11161-11163)CAA>CAT	p.Q3721H	ABCA13_uc010kys.1_Missense_Mutation_p.Q795H|ABCA13_uc003tos.1_Missense_Mutation_p.Q547H|ABCA13_uc010kyt.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3721	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CCTTTGGACAAGGGGTATTTT	0.413			NA											6	29					0	0	0.001984	0	0
IKZF1	10320	broad.mit.edu	37	7	50468246	50468246	+	Missense_Mutation	SNP	T	T	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr7:50468246T>A	uc003tow.3	+	9	1649	c.1481T>A	c.(1480-1482)ATG>AAG	p.M494K	IKZF1_uc003tox.3_Missense_Mutation_p.M452K|IKZF1_uc003toy.3_Missense_Mutation_p.M452K|IKZF1_uc011kck.1_Missense_Mutation_p.M407K|IKZF1_uc003toz.3_Missense_Mutation_p.M464K|IKZF1_uc010kyx.2_Missense_Mutation_p.M234K|IKZF1_uc003tpa.3_Missense_Mutation_p.M236K	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	494	C2H2-type 6.				cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding			haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				GAGTGCAACATGTGCGGCTAC	0.602			NA	D		ALL								3	30					0	0	0.004672	0	0
EGFR	1956	broad.mit.edu	37	7	55259515	55259515	+	Missense_Mutation	SNP	T	T	G	rs121434568		TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr7:55259515T>G	uc003tqk.2	+	21	2819	c.2573T>G	c.(2572-2574)CTG>CGG	p.L858R	EGFR_uc010kzg.1_Missense_Mutation_p.L813R|EGFR_uc011kco.1_Missense_Mutation_p.L805R|uc003tqo.2_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	858	Cytoplasmic (Potential).|Protein kinase.		L -> R (found in a lung cancer sample; somatic mutation; constitutively activated enzyme with strongly increased kinase activity).|L -> M (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L858R(3429)|p.L858L(4)|p.L858M(4)|p.L858Q(3)|p.L858A(2)|p.L858W(1)|p.L858P(1)|p.L858K(1)|p.L858G(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GATTTTGGGCTGGCCAAACTG	0.537		L858R(NCIH1975_LUNG)	8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			15	75					0	0	0.00245	0	0
PEX1	5189	broad.mit.edu	37	7	92130962	92130962	+	Missense_Mutation	SNP	G	G	T	rs145430946	byFrequency	TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr7:92130962G>T	uc003uly.2	-	15	2538	c.2442C>A	c.(2440-2442)TTC>TTA	p.F814L	PEX1_uc011khr.1_Missense_Mutation_p.F606L|PEX1_uc010ley.2_Missense_Mutation_p.F757L|PEX1_uc011khs.1_Missense_Mutation_p.F492L|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	814					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			GAGCCTTTTGGAAGTCCAATG	0.363			NA											9	72					2.74318e-10	3.66236e-10	0.006214	1	0
MUC17	140453	broad.mit.edu	37	7	100682069	100682069	+	Missense_Mutation	SNP	T	T	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr7:100682069T>A	uc003uxp.1	+	3	7425	c.7372T>A	c.(7372-7374)TTA>ATA	p.L2458I	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2458	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|39.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AACCACTCCGTTAGCAAGTAT	0.532			NA											32	207					0	0	0.009535	0	0
LAMB4	22798	broad.mit.edu	37	7	107708591	107708591	+	Missense_Mutation	SNP	G	G	C	rs140790836	byFrequency	TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr7:107708591G>C	uc010ljo.1	-	19	2400	c.2316C>G	c.(2314-2316)CAC>CAG	p.H772Q	LAMB4_uc003vey.2_Missense_Mutation_p.H772Q	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	772	Laminin EGF-like 6.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						AGCCCTGGGGGTGACACTTGC	0.547			NA											24	29					0	0	0.00333	0	0
TMEM168	64418	broad.mit.edu	37	7	112423771	112423771	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr7:112423771C>A	uc003vgn.2	-	2	1502	c.1110G>T	c.(1108-1110)TTG>TTT	p.L370F	TMEM168_uc010lju.2_Missense_Mutation_p.L370F|TMEM168_uc011kmr.1_Intron	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	370	Helical; (Potential).					integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2						AAACTGCTCCCAAAATCGCTG	0.398			NA											50	91					1.56793e-16	2.3111e-16	0.01441	1	0
SMO	6608	broad.mit.edu	37	7	128851599	128851599	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr7:128851599G>T	uc003vor.2	+	11	2204	c.1924G>T	c.(1924-1926)GTG>TTG	p.V642L	SMO_uc003vos.2_Missense_Mutation_p.V317L	NM_005631	NP_005622	Q99835	SMO_HUMAN	smoothened precursor	642	Cytoplasmic (Potential).				adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(19)|large_intestine(10)|central_nervous_system(3)|upper_aerodigestive_tract(2)|biliary_tract(1)|lung(1)|liver(1)	37						TGTCACCCCTGTGGCAACTCC	0.602			NA	Mis		skin basal cell 								19	48					7.45023e-12	1.03815e-11	0.010504	1	0
AKR1B15	441282	broad.mit.edu	37	7	134254279	134254279	+	Missense_Mutation	SNP	A	A	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr7:134254279A>G	uc011kpr.1	+	5	732	c.433A>G	c.(433-435)AAG>GAG	p.K145E	AKR1B15_uc003vrt.2_Missense_Mutation_p.K117E|AKR1B15_uc011kps.1_Missense_Mutation_p.K117E	NM_001080538	NP_001074007	C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	145							oxidoreductase activity			ovary(1)	1						ACAGGGATTCAAGGTTTGAGT	0.348			NA											20	57					0	0	0.012319	0	0
TRPV6	55503	broad.mit.edu	37	7	142583208	142583208	+	Silent	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr7:142583208C>T	uc003wbx.1	-	1	270	c.54G>A	c.(52-54)AAG>AAA	p.K18K		NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	18	Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					ATCTGCAGAACTTGCTCCATA	0.612			NA											16	139					0	0	0.004007	0	0
MLL3	58508	broad.mit.edu	37	7	151873473	151873473	+	Missense_Mutation	SNP	G	G	A	rs141345566		TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr7:151873473G>A	uc003wla.2	-	38	9284	c.9065C>T	c.(9064-9066)ACC>ATC	p.T3022I	MLL3_uc003wkz.2_Missense_Mutation_p.T2083I|MLL3_uc003wky.2_Missense_Mutation_p.T531I	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3022	Gln-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CATGCTACTGGTACCAGACTG	0.478	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								25	89					0	0	0.004656	0	0
CSMD1	64478	broad.mit.edu	37	8	2823383	2823383	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr8:2823383G>T	uc011kwk.1	-	59	9587	c.9197C>A	c.(9196-9198)CCA>CAA	p.P3066Q	CSMD1_uc011kwj.1_Missense_Mutation_p.P2395Q|CSMD1_uc010lrg.2_Intron	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3066	Extracellular (Potential).|Sushi 24.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GACATAGCCTGGGTTACACTG	0.483			NA											9	4					4.68919e-08	5.80458e-08	0.008291	1	0
OPRK1	4986	broad.mit.edu	37	8	54142117	54142118	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr8:54142117_54142118GG>TT	uc003xrh.1	-	3	1257_1258	c.882_883CC>AA	c.(880-885)ATCCTG>ATAATG	p.L295M	OPRK1_uc003xri.1_Missense_Mutation_p.L295M|OPRK1_uc010lyc.1_Missense_Mutation_p.L206M	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	295	Helical; Name=6; (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	GCCTCCACCAGGATGAATATGT	0.554			NA											12	11					0	0	0.004672	0	0
TRPS1	7227	broad.mit.edu	37	8	116631634	116631634	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr8:116631634C>A	uc003ynz.2	-	2	1111	c.652G>T	c.(652-654)GAG>TAG	p.E218*	TRPS1_uc011lhy.1_Nonsense_Mutation_p.E222*|TRPS1_uc003yny.2_Nonsense_Mutation_p.E231*|TRPS1_uc010mcy.2_Nonsense_Mutation_p.E218*	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	218					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TCCTGAAGCTCTGGAGACAGA	0.453			NA							Langer-Giedion_syndrome				41	76					1.5731e-28	2.50713e-28	0.011902	1	0
ZC3H3	23144	broad.mit.edu	37	8	144557623	144557623	+	Silent	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr8:144557623G>A	uc003yyd.2	-	5	1877	c.1848C>T	c.(1846-1848)CTC>CTT	p.L616L		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	616					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			AGGTCTTGGAGAGCTTGTTGG	0.672			NA											5	47					0	0	0.001984	0	0
PLEC	5339	broad.mit.edu	37	8	144991017	144991017	+	Silent	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr8:144991017G>A	uc003zaf.1	-	32	13553	c.13383C>T	c.(13381-13383)CCC>CCT	p.P4461P	PLEC_uc003zab.1_Silent_p.P4324P|PLEC_uc003zac.1_Silent_p.P4328P|PLEC_uc003zad.2_Silent_p.P4324P|PLEC_uc003zae.1_Silent_p.P4292P|PLEC_uc003zag.1_Silent_p.P4302P|PLEC_uc003zah.2_Silent_p.P4310P|PLEC_uc003zaj.2_Silent_p.P4351P	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4461	Globular 2.|Plectin 30.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CACCGGTGCTGGGGTCGATGA	0.652			NA											8	58					0	0	0.00308	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18622297	18622297	+	Silent	SNP	C	C	A	rs143328816		TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr9:18622297C>A	uc003zne.3	+	5	658	c.531C>A	c.(529-531)GTC>GTA	p.V177V	ADAMTSL1_uc003znb.2_Silent_p.V177V|ADAMTSL1_uc003znc.3_Silent_p.V177V	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	177						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		ACTGTGGGGTCTGCAACGGAG	0.527			NA											18	32					1.67942e-08	2.11757e-08	0.006122	1	0
FLJ46321	389763	broad.mit.edu	37	9	84608465	84608465	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr9:84608465G>T	uc004amn.2	+	4	3127	c.3080G>T	c.(3079-3081)AGA>ATA	p.R1027I		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1027						integral to membrane					0						TCCCTTAGAAGAGGTACTACA	0.448			NA											65	137					1.09529e-45	1.81364e-45	0.01441	1	0
C9orf79	286234	broad.mit.edu	37	9	90502272	90502272	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr9:90502272G>T	uc004app.3	+	4	2905	c.2870G>T	c.(2869-2871)GGG>GTG	p.G957V		NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	957						integral to membrane				ovary(3)	3						AAGGGCAGGGGGTGTTCTCAG	0.622			NA											12	23					1.61879e-10	2.17259e-10	0.013537	1	0
PTPDC1	138639	broad.mit.edu	37	9	96859891	96859891	+	Missense_Mutation	SNP	A	A	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr9:96859891A>G	uc004auf.1	+	7	1221	c.881A>G	c.(880-882)AAA>AGA	p.K294R	PTPDC1_uc004aug.1_Missense_Mutation_p.K294R|PTPDC1_uc004auh.1_Missense_Mutation_p.K346R|PTPDC1_uc010mrj.1_Missense_Mutation_p.K348R|PTPDC1_uc010mri.1_Missense_Mutation_p.K346R	NM_177995	NP_818931	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	294							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1						CTAGTTTGCAAATTGCTGCTG	0.458			NA											14	56					0	0	0.001855	0	0
ZNF169	169841	broad.mit.edu	37	9	97054749	97054749	+	Nonsense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr9:97054749G>T	uc004aum.1	+	3	265	c.160G>T	c.(160-162)GGA>TGA	p.G54*	ZNF169_uc004aun.2_Nonsense_Mutation_p.G54*|ZNF169_uc004auo.2_Nonsense_Mutation_p.G54*	NM_194320	NP_919301	Q14929	ZN169_HUMAN	zinc finger protein 169	54	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.136)				GGTCTCCCTGGGTAAGGCTGG	0.483			NA											6	32					2.0095e-06	2.38336e-06	0.001984	1	0
ZNF462	58499	broad.mit.edu	37	9	109746587	109746587	+	Missense_Mutation	SNP	A	A	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr9:109746587A>T	uc004bcz.2	+	10	7242	c.6953A>T	c.(6952-6954)CAT>CTT	p.H2318L	ZNF462_uc010mto.2_Missense_Mutation_p.H2227L|ZNF462_uc004bda.2_Missense_Mutation_p.H2226L|ZNF462_uc011lvz.1_Missense_Mutation_p.H275L|uc004bdc.1_Intron	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	2318	C2H2-type 25.				transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						CTCCAGCAACATATAGAAAAG	0.483			NA											9	58					0	0	0.004482	0	0
COL5A1	1289	broad.mit.edu	37	9	137704300	137704300	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr9:137704300G>T	uc004cfe.2	+	47	4078	c.3696G>T	c.(3694-3696)TTG>TTT	p.L1232F		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1232	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CTCAGGGTTTGCCAGGACCTC	0.542			NA											4	30					0.00909568	0.00954485	0.009096	1	0
SOHLH1	402381	broad.mit.edu	37	9	138590880	138590880	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr9:138590880G>T	uc004cgl.2	-	2	219	c.158C>A	c.(157-159)TCC>TAC	p.S53Y	SOHLH1_uc010nbe.2_Missense_Mutation_p.S53Y	NM_001012415	NP_001012415	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic	53					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)	2		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		CCGAAGGCAGGAGCTGGGACC	0.701			NA											14	31					4.3838e-07	5.27297e-07	0.001855	1	0
ARSF	416	broad.mit.edu	37	X	3007540	3007540	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:3007540C>A	uc004cre.1	+	7	1055	c.834C>A	c.(832-834)CAC>CAA	p.H278Q	ARSF_uc004crf.1_Missense_Mutation_p.H278Q	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	278						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TTCTCAGGCACAGTAAGGAAA	0.428			NA											27	103					1.68575e-08	2.11757e-08	0.007291	1	0
PLP2	5355	broad.mit.edu	37	X	49029519	49029519	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:49029519C>A	uc004dmx.2	+	2	215	c.140C>A	c.(139-141)CCA>CAA	p.P47Q		NM_002668	NP_002659	Q04941	PLP2_HUMAN	proteolipid protein 2 (colonic	47	MARVEL.				chemotaxis|cytokine-mediated signaling pathway	endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	chemokine binding|ion transmembrane transporter activity				0						GCCTCCACACCAGGCTACTCC	0.493			NA											9	33					2.17888e-05	2.50276e-05	0.006214	1	0
MAGEH1	28986	broad.mit.edu	37	X	55479280	55479280	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:55479280A>C	uc004dum.2	+	1	743	c.473A>C	c.(472-474)GAG>GCG	p.E158A		NM_014061	NP_054780	Q9H213	MAGH1_HUMAN	melanoma antigen, family H, 1 protein	158	MAGE.				apoptosis					ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						AGTCCGGTGGAGTATGAGTTC	0.517			NA											6	59					0	0	0.001168	0	0
MAGEH1	28986	broad.mit.edu	37	X	55479393	55479393	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:55479393G>A	uc004dum.2	+	1	856	c.586G>A	c.(586-588)GAC>AAC	p.D196N		NM_014061	NP_054780	Q9H213	MAGH1_HUMAN	melanoma antigen, family H, 1 protein	196	MAGE.				apoptosis					ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						TTGTAATTATGACTGGGATTC	0.522			NA											11	77					0	0	0.010729	0	0
POU3F4	5456	broad.mit.edu	37	X	82763714	82763714	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:82763714G>T	uc004eeg.2	+	1	446	c.382G>T	c.(382-384)GGC>TGC	p.G128C		NM_000307	NP_000298	P49335	PO3F4_HUMAN	POU domain, class 3, transcription factor 4	128					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CACGTCAAGCGGCCAACCCCT	0.667			NA											10	10					9.70103e-10	1.2686e-09	0.008291	1	0
PAK3	5063	broad.mit.edu	37	X	110366401	110366401	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:110366401G>A	uc004epa.2	+	1	97	c.70G>A	c.(70-72)GAT>AAT	p.D24N	PAK3_uc010npt.1_Missense_Mutation_p.D24N|PAK3_uc010npu.1_Missense_Mutation_p.D24N|PAK3_uc004eoy.1_5'UTR|PAK3_uc004eoz.2_Missense_Mutation_p.D24N|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_Missense_Mutation_p.D24N|PAK3_uc010npw.1_Missense_Mutation_p.D24N|uc004epb.2_5'Flank	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	24					multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						TAACAACCGGGATTCTTCAGC	0.488			NA								TSP Lung(19;0.15)			78	71					0	0	0.01441	0	0
AGTR2	186	broad.mit.edu	37	X	115304043	115304043	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:115304043G>A	uc004eqh.3	+	3	717	c.510G>A	c.(508-510)ATG>ATA	p.M170I		NM_000686	NP_000677	P50052	AGTR2_HUMAN	angiotensin II receptor, type 2	170	Helical; Name=4; (Potential).				behavior|blood vessel remodeling|brain development|G-protein signaling, coupled to cGMP nucleotide second messenger|intracellular protein kinase cascade|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of heart rate|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of nitric-oxide synthase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin		angiotensin type II receptor activity|receptor antagonist activity			ovary(2)|lung(1)	3						TTTGGTGTATGGCCTGTTTGT	0.418			NA											17	280					0	0	0.006122	0	0
KIAA1210	57481	broad.mit.edu	37	X	118284535	118284535	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:118284535G>A	uc004era.3	-	1	8	c.8C>T	c.(7-9)GCC>GTC	p.A3V		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	3										ovary(4)|skin(1)	5						CGTCCAGCCGGCCCTCATTTC	0.662			NA											24	46					0	0	0.00333	0	0
ATP1B4	23439	broad.mit.edu	37	X	119496040	119496040	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:119496040G>A	uc004esr.2	+	1	101	c.17G>A	c.(16-18)CGG>CAG	p.R6Q	ATP1B4_uc004esq.2_Missense_Mutation_p.R6Q|ATP1B4_uc011mtx.1_Missense_Mutation_p.R6Q|ATP1B4_uc011mty.1_Missense_Mutation_p.R6Q	NM_001142447	NP_001135919	Q9UN42	AT1B4_HUMAN	ATPase, (Na+)/K+ transporting, beta 4	6	Nuclear (Potential).				ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			ovary(1)|skin(1)	2						AGGCAACTCCGGTCCAGAAGG	0.522			NA											12	198					0	0	0.00245	0	0
UTP14A	10813	broad.mit.edu	37	X	129063425	129063425	+	Silent	SNP	C	C	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:129063425C>G	uc004euz.2	+	15	2185	c.2157C>G	c.(2155-2157)CCC>CCG	p.P719P	UTP14A_uc011mup.1_Silent_p.P667P|UTP14A_uc011muq.1_Silent_p.P665P	NM_006649	NP_006640	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	719					rRNA processing	nucleolus|small-subunit processome	protein binding			ovary(2)	2						TGACTACTCCCAAGGTCGTCA	0.507			NA											17	78					0	0	0.00499	0	0
BRS3	680	broad.mit.edu	37	X	135570341	135570341	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:135570341C>T	uc004ezv.1	+	1	217	c.68C>T	c.(67-69)TCA>TTA	p.S23L		NM_001727	NP_001718	P32247	BRS3_HUMAN	bombesin-like receptor 3	23	Extracellular (Potential).				adult feeding behavior|glucose metabolic process|regulation of blood pressure	integral to membrane|plasma membrane	bombesin receptor activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					ACAGAATCATCAAGCTCTGTG	0.393			NA											5	99					0	0	0.000602	0	0
HTATSF1	27336	broad.mit.edu	37	X	135592353	135592353	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:135592353C>G	uc004ezw.2	+	9	1459	c.1037C>G	c.(1036-1038)GCA>GGA	p.A346G	HTATSF1_uc004ezx.2_Missense_Mutation_p.A346G	NM_001163280	NP_001156752	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	346	RRM 2.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					ACTGCCCAGGCATGGGATGGG	0.448			NA											77	298					0	0	0.01441	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994659	140994659	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:140994659C>A	uc004fbt.2	+	4	1755	c.1469C>A	c.(1468-1470)ACT>AAT	p.T490N	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	490							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCCTCCACTTTATTGAGT	0.498			NA								HNSCC(15;0.026)			52	243					8.28887e-21	1.26567e-20	0.01441	1	0
MAGEC2	51438	broad.mit.edu	37	X	141291003	141291003	+	Silent	SNP	C	C	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:141291003C>G	uc004fbu.1	-	3	1119	c.771G>C	c.(769-771)GGG>GGC	p.G257G		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	257	MAGE.					cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CAGCATATACCCCTACTGCAT	0.532			NA								HNSCC(46;0.14)			61	178					0	0	0.01441	0	0
SLITRK2	84631	broad.mit.edu	37	X	144905670	144905670	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:144905670C>T	uc004fcd.2	+	5	2717	c.1727C>T	c.(1726-1728)GCT>GTT	p.A576V	SLITRK2_uc010nsp.2_Missense_Mutation_p.A576V|SLITRK2_uc010nso.2_Missense_Mutation_p.A576V|SLITRK2_uc011mwq.1_Missense_Mutation_p.A576V|SLITRK2_uc011mwr.1_Missense_Mutation_p.A576V|SLITRK2_uc011mws.1_Missense_Mutation_p.A576V|SLITRK2_uc004fcg.2_Missense_Mutation_p.A576V|SLITRK2_uc011mwt.1_Missense_Mutation_p.A576V	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	576	Extracellular (Potential).|LRRCT 2.					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					GGGAGGGAGGCTATCTGTCCA	0.473			NA											30	50					0	0	0.009535	0	0
CXorf1	9142	broad.mit.edu	37	X	144909297	144909297	+	Silent	SNP	A	A	G			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:144909297A>G	uc004fch.2	+	1	370	c.102A>G	c.(100-102)CTA>CTG	p.L34L		NM_004709	NP_004700	O96002	CX001_HUMAN	hypothetical protein LOC9142	34											0	Acute lymphoblastic leukemia(192;6.56e-05)					TTAACTCACTAGCATCCCCAC	0.279			NA											31	83					0	0	0.007291	0	0
MTM1	4534	broad.mit.edu	37	X	149828153	149828153	+	Missense_Mutation	SNP	A	A	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:149828153A>T	uc004fef.3	+	12	1353	c.1277A>T	c.(1276-1278)GAT>GTT	p.D426V	MTM1_uc011mxx.1_RNA|MTM1_uc011mxy.1_Missense_Mutation_p.D389V|MTM1_uc011mxz.1_Missense_Mutation_p.D311V|MTM1_uc010nte.2_Missense_Mutation_p.D294V	NM_000252	NP_000243	Q13496	MTM1_HUMAN	myotubularin	426	Myotubularin phosphatase.				endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GGTCATGGTGATAAAAACCAC	0.333			NA											6	69					0	0	0.001984	0	0
FAM50A	9130	broad.mit.edu	37	X	153678637	153678637	+	Silent	SNP	C	C	T			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:153678637C>T	uc004fll.3	+	12	1079	c.981C>T	c.(979-981)TAC>TAT	p.Y327Y		NM_004699	NP_004690	Q14320	FA50A_HUMAN	XAP-5 protein	327					spermatogenesis	nucleus				ovary(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGGAACCCTACGACCCTGAAA	0.622			NA											6	69					0	0	0.004482	0	0
RSBN1	54665	broad.mit.edu	37	1	114308968	114308986	+	Frame_Shift_Del	DEL	ATTTCTAGGGATGAAGTAG	ATTTCTAGGGATGAAGTAG	-			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	ATTTCTAGGGATGAAGTAG	ATTTCTAGGGATGAAGTAG	-	-	ATTTCTAGGGATGAAGTAG	ATTTCTAGGGATGAAGTAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr1:114308968_114308986delATTTCTAGGGATGAAGTAG	uc001edq.2	-	7	2061_2079	c.2025_2043delCTACTTCATCCCTAGAAAT	c.(2023-2043)ATCTACTTCATCCCTAGAAATfs	p.I675fs	RSBN1_uc001edr.2_RNA	NM_018364	NP_060834	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	675_681						nucleus				ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GATGAATGACATTTCTAGGGATGAAGTAGATATCATTGT	0.438			NA											37	137	---	---	---	---	NA	NA	NA	NA	NA
LTBP2	4053	broad.mit.edu	37	14	74989609	74989610	+	Frame_Shift_Ins	INS	-	-	TT			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr14:74989609_74989610insTT	uc001xqa.2	-	16	2929_2930	c.2542_2543insAA	c.(2542-2544)TGCfs	p.C848fs		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	848	EGF-like 4.				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		TCCAGCAGCGCATCTGTCAATG	0.619			NA											7	19	---	---	---	---	NA	NA	NA	NA	NA
KRT13	3860	broad.mit.edu	37	17	39658805	39658806	+	Frame_Shift_Ins	INS	-	-	A	rs148296285	byFrequency	TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr17:39658805_39658806insA	uc002hwu.1	-	6	1127_1128	c.1064_1065insT	c.(1063-1065)CGCfs	p.R355fs	KRT13_uc002hwv.1_Frame_Shift_Ins_p.R355fs|KRT13_uc002hww.2_Frame_Shift_Ins_p.R248fs|KRT13_uc010wfr.1_Frame_Shift_Ins_p.R248fs|KRT13_uc010cxo.2_Frame_Shift_Ins_p.R355fs|KRT13_uc002hwx.1_Frame_Shift_Ins_p.R343fs	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	355	Rod.|Coil 2.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				GCAGGGCATAGCGGCACTCCGT	0.599			NA											11	107	---	---	---	---	NA	NA	NA	NA	NA
GATAD2A	54815	broad.mit.edu	37	19	19612093	19612093	+	Frame_Shift_Del	DEL	C	C	-			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr19:19612093delC	uc010xqt.1	+	9	1680	c.1368delC	c.(1366-1368)AGCfs	p.S456fs	GATAD2A_uc010xqu.1_Frame_Shift_Del_p.S85fs|GATAD2A_uc010xqv.1_Frame_Shift_Del_p.S476fs|GATAD2A_uc010xqw.1_Frame_Shift_Del_p.S284fs	NM_017660	NP_060130	Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	456	GATA-type.				DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGCACACCAGCCGGCTGAAGG	0.637			NA											7	31	---	---	---	---	NA	NA	NA	NA	NA
STXBP5L	9515	broad.mit.edu	37	3	120998798	120998798	+	Frame_Shift_Del	DEL	T	T	-			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chr3:120998798delT	uc003eec.3	+	19	2245	c.2105delT	c.(2104-2106)ATTfs	p.I702fs	STXBP5L_uc011bji.1_Frame_Shift_Del_p.I702fs	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	702	WD 10.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		AAACAGTTCATTGCAGGTAGG	0.368			NA											15	55	---	---	---	---	NA	NA	NA	NA	NA
BMX	660	broad.mit.edu	37	X	15544216	15544219	+	Splice_Site	DEL	TGAG	TGAG	-			TCGA-67-6217-01A-11D-1753-08	TCGA-67-6217-10A-01D-1753-08	TGAG	TGAG	-	-	TGAG	TGAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cb98d825-668f-4b16-a05e-501e1c94f3fe	3f3bd303-83e1-4896-8c92-b287da34fbf8	g.chrX:15544216_15544219delTGAG	uc004cww.2	+	9	1072	c.884_splice	c.e9+1	p.D295_splice	BMX_uc004cwx.3_Splice_Site_p.D295_splice|BMX_uc004cwy.3_Splice_Site_p.D295_splice	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase						cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					TGGATGATTATGAGTGAGTATTGA	0.387			NA											10	131	---	---	---	---	NA	NA	NA	NA	NA
