Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
UBIAD1	29914	broad.mit.edu	37	1	11333871	11333871	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr1:11333871C>A	uc001asg.2	+	1	617	c.283C>A	c.(283-285)CAC>AAC	p.H95N		NM_013319	NP_037451	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	95	Helical; (Potential).				menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		CCTGGCTGTGCACGGGGCCGG	0.567			NA											34	47					1.04594e-18	1.29696e-18	0.00623	1	0
UBR4	23352	broad.mit.edu	37	1	19501491	19501491	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr1:19501491G>A	uc001bbi.2	-	21	2814	c.2810C>T	c.(2809-2811)TCC>TTC	p.S937F	UBR4_uc001bbm.1_Missense_Mutation_p.S148F	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	937					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GGCTTCTGGGGACAGGACACA	0.403			NA											37	34					0	0	0.00623	0	0
RIMS3	9783	broad.mit.edu	37	1	41101649	41101649	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr1:41101649T>C	uc001cfu.1	-	4	767	c.298A>G	c.(298-300)ACA>GCA	p.T100A	RIMS3_uc001cfv.1_Missense_Mutation_p.T100A	NM_014747	NP_055562	Q9UJD0	RIMS3_HUMAN	regulating synaptic membrane exocytosis 3	100					neurotransmitter transport	cell junction|synapse					0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.47e-17)			CCCTGGCGTGTGACCCGGCTC	0.687			NA											6	46					0	0	0.001984	0	0
NFIA	4774	broad.mit.edu	37	1	61869785	61869785	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr1:61869785A>T	uc001czw.2	+	8	1569	c.1085A>T	c.(1084-1086)CAT>CTT	p.H362L	NFIA_uc001czy.2_Missense_Mutation_p.H354L|NFIA_uc010oos.1_Missense_Mutation_p.H407L|NFIA_uc001czv.2_Missense_Mutation_p.H362L|NFIA_uc001czx.2_Missense_Mutation_p.H10L|NFIA_uc009wae.2_5'Flank	NM_001134673	NP_001128145	Q12857	NFIA_HUMAN	nuclear factor I/A isoform 1	362					DNA replication|viral genome replication	cell junction|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)|skin(1)	2						GCAAGTCCGCATGCAACACCA	0.488			NA											25	120					0	0	0.005443	0	0
DNAJC6	9829	broad.mit.edu	37	1	65851413	65851414	+	Nonsense_Mutation	DNP	TG	TG	AT			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr1:65851413_65851414TG>AT	uc001dcd.1	+	7	812_813	c.648_649TG>AT	c.(646-651)TGTGAC>TGATAC	p.216_217CD>*Y	DNAJC6_uc001dcc.1_Nonsense_Mutation_p.247_248CD>*Y|DNAJC6_uc010opc.1_Nonsense_Mutation_p.203_204CD>*Y|DNAJC6_uc001dce.1_Nonsense_Mutation_p.273_274CD>*Y	NM_014787	NP_055602	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	216_217	Phosphatase tensin-type.				cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3						GCTATATGTGTGACCTACTGGC	0.46			NA											8	48					0	0	0.004672	0	0
C1orf173	127254	broad.mit.edu	37	1	75037335	75037335	+	Silent	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr1:75037335G>A	uc001dgg.2	-	14	4278	c.4059C>T	c.(4057-4059)GCC>GCT	p.A1353A		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1353	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TCTCCTCTGCGGCTGTTTCTG	0.512			NA											52	63					0	0	0.01441	0	0
MCOLN3	55283	broad.mit.edu	37	1	85487754	85487754	+	Missense_Mutation	SNP	T	T	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr1:85487754T>G	uc001dkp.2	-	11	1412	c.1319A>C	c.(1318-1320)AAG>ACG	p.K440T	MCOLN3_uc001dko.2_Missense_Mutation_p.K59T|MCOLN3_uc001dkq.2_Missense_Mutation_p.K384T	NM_018298	NP_060768	Q8TDD5	MCLN3_HUMAN	mucolipin 3	440						integral to membrane	ion channel activity			skin(1)	1				all cancers(265;0.00957)|Epithelial(280;0.0254)		TATCAGTACCTTGTCATGGTA	0.423			NA											13	74					0	0	0.004007	0	0
SYPL2	284612	broad.mit.edu	37	1	110019462	110019462	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr1:110019462C>A	uc001dxp.2	+	4	685	c.319C>A	c.(319-321)CTC>ATC	p.L107I	SYPL2_uc001dxo.2_Missense_Mutation_p.L107I|SYPL2_uc010ovk.1_Missense_Mutation_p.L107I|SYPL2_uc001dxq.2_Missense_Mutation_p.L15I	NM_001040709	NP_001035799	Q5VXT5	SYPL2_HUMAN	mitsugumin 29	107	Vesicular (Potential).|MARVEL.					integral to membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0436)|READ - Rectum adenocarcinoma(129;0.0698)|Epithelial(280;0.0808)|all cancers(265;0.0869)|LUSC - Lung squamous cell carcinoma(189;0.231)		GACCATGCACCTCATGGGGGA	0.567			NA											6	33					0.00116845	0.00124903	0.001168	1	0
C1orf51	148523	broad.mit.edu	37	1	150259060	150259060	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr1:150259060A>T	uc001euh.2	+	6	988	c.852A>T	c.(850-852)TTA>TTT	p.L284F	C1orf51_uc001eui.2_Missense_Mutation_p.L196F|C1orf51_uc001euj.2_Missense_Mutation_p.L284F	NM_144697	NP_653298	Q8N365	CA051_HUMAN	hypothetical protein LOC148523	284											0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			ATGGTCCTTTAGGCACTGGAA	0.552			NA											83	112					0	0	0.01441	0	0
LCE1B	353132	broad.mit.edu	37	1	152785211	152785211	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr1:152785211A>G	uc001faq.2	+	1	765	c.289A>G	c.(289-291)AGC>GGC	p.S97G		NM_178349	NP_848126	Q5T7P3	LCE1B_HUMAN	late cornified envelope 1B	97	Gly-rich.				keratinization						0	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGGCTGCTGCAGCCAGCCCTC	0.647			NA											50	46					0	0	0.01441	0	0
TMEM79	84283	broad.mit.edu	37	1	156255080	156255080	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr1:156255080C>G	uc010phi.1	+	2	259	c.63C>G	c.(61-63)AGC>AGG	p.S21R	SMG5_uc001foc.3_5'Flank|TMEM79_uc001fod.2_Intron|TMEM79_uc009wrw.2_Missense_Mutation_p.S21R	NM_032323	NP_115699	Q9BSE2	TMM79_HUMAN	transmembrane protein 79	21						integral to membrane				central_nervous_system(1)	1	Hepatocellular(266;0.158)					CAGAGAAGAGCTCACCCCAGG	0.602			NA											37	48					0	0	0.00623	0	0
BCAN	63827	broad.mit.edu	37	1	156628465	156628466	+	Silent	DNP	CC	CC	AA			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr1:156628465_156628466CC>AA	uc001fpp.2	+	13	2904_2905	c.2568_2569CC>AA	c.(2566-2571)ATCCGA>ATAAGA	p.856_857IR>IR		NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	856_857	Sushi.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGCCGCTGATCCGATGCCAAGA	0.634			NA											48	95					0	0	0.004672	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156946817	156946817	+	Silent	SNP	C	C	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr1:156946817C>T	uc001fqo.2	-	7	1580	c.540G>A	c.(538-540)CAG>CAA	p.Q180Q	ARHGEF11_uc001fqn.2_Silent_p.Q180Q	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	180					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TCCTGAGGATCTGGGTGGCAT	0.428			NA											121	127					0	0	0.01441	0	0
PAPPA2	60676	broad.mit.edu	37	1	176738760	176738760	+	Silent	SNP	A	A	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr1:176738760A>G	uc001gkz.2	+	16	5505	c.4341A>G	c.(4339-4341)ACA>ACG	p.T1447T	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1447	Sushi 1.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TTCTGCTCACATGTTCTTCTG	0.478			NA											31	48					0	0	0.003271	0	0
RYR2	6262	broad.mit.edu	37	1	237787114	237787114	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr1:237787114C>A	uc001hyl.1	+	39	6086	c.5966C>A	c.(5965-5967)CCA>CAA	p.P1989Q		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1989	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGTCCATGTCCAGAAGAAATT	0.318			NA											25	26					6.32553e-13	7.47015e-13	0.004656	1	0
RYR2	6262	broad.mit.edu	37	1	237791169	237791169	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr1:237791169G>A	uc001hyl.1	+	41	6349	c.6229G>A	c.(6229-6231)GAC>AAC	p.D2077N		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2077	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGTCATTGAAGACCCCGAGCT	0.493			NA											10	8					0	0	0.008291	0	0
ZP4	57829	broad.mit.edu	37	1	238053780	238053780	+	Silent	SNP	A	A	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr1:238053780A>T	uc001hym.2	-	1	156	c.156T>A	c.(154-156)CCT>CCA	p.P52P	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	52	Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TTAGTACAGGAGGAGACGTTG	0.498	NSCLC(166;160 2029 11600 18754 19936)		NA											8	25					0	0	0.004482	0	0
OR2T34	127068	broad.mit.edu	37	1	248737471	248737471	+	Silent	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr1:248737471G>A	uc001iep.1	-	1	588	c.588C>T	c.(586-588)GAC>GAT	p.D196D		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	196	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGAGGGAGACGTCAGAGCAGG	0.517			NA											45	83					0	0	0.013114	0	0
CUL2	8453	broad.mit.edu	37	10	35320243	35320243	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr10:35320243C>G	uc001ixv.2	-	14	1581	c.1371G>C	c.(1369-1371)ATG>ATC	p.M457I	CUL2_uc009xma.2_Missense_Mutation_p.M326I|CUL2_uc010qer.1_Missense_Mutation_p.M476I|CUL2_uc001ixw.2_Missense_Mutation_p.M457I|CUL2_uc010qes.1_Missense_Mutation_p.M394I	NM_003591	NP_003582	Q13617	CUL2_HUMAN	cullin 2	457					cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			ovary(3)	3						ATTTGTTGATCATGGCTTCTT	0.323			NA											15	18					0	0	0.00245	0	0
STOX1	219736	broad.mit.edu	37	10	70645813	70645813	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr10:70645813G>A	uc001jos.2	+	3	2348	c.2261G>A	c.(2260-2262)GGC>GAC	p.G754D	STOX1_uc001jor.2_Intron|STOX1_uc009xpy.2_Intron|STOX1_uc001joq.2_Missense_Mutation_p.G644D	NM_001130161	NP_001123633	Q6ZVD7	STOX1_HUMAN	storkhead box 1 isoform a	754						cytoplasm|nucleolus	DNA binding			kidney(1)|skin(1)	2						ATGCTGCCTGGCCACAGTCAG	0.428			NA											39	31					0	0	0.00623	0	0
HMX3	340784	broad.mit.edu	37	10	124896850	124896850	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr10:124896850G>A	uc010quc.1	+	2	677	c.677G>A	c.(676-678)CGC>CAC	p.R226H		NM_001105574	NP_001099044	A6NHT5	HMX3_HUMAN	H6 family homeobox 3	226					cell differentiation	nucleus	sequence-specific DNA binding transcription factor activity				0		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.122)|COAD - Colon adenocarcinoma(40;0.141)		CCGGCGTGCCGCAAGAAGAAG	0.672			NA											4	5					0	0	0.009096	0	0
DENND5A	23258	broad.mit.edu	37	11	9215164	9215164	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr11:9215164C>G	uc001mhl.2	-	5	1269	c.1014G>C	c.(1012-1014)CAG>CAC	p.Q338H	DENND5A_uc010rbw.1_Missense_Mutation_p.Q338H|DENND5A_uc010rbx.1_RNA	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	338	DENN.									liver(1)	1						CATAGACATGCTGCCACTGGA	0.473			NA											21	26					0	0	0.00333	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947393	57947393	+	Silent	SNP	G	G	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr11:57947393G>T	uc001nmj.2	+	3	793	c.477G>T	c.(475-477)CGG>CGT	p.R159R		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	159	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				CCTTGGTGCGGACAGTCTCAG	0.537			NA											16	37					3.45872e-05	3.79541e-05	0.004007	1	0
OR5B2	390190	broad.mit.edu	37	11	58190389	58190389	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr11:58190389T>A	uc010rkg.1	-	1	346	c.346A>T	c.(346-348)ATG>TTG	p.M116L		NM_001005566	NP_001005566	Q96R09	OR5B2_HUMAN	olfactory receptor, family 5, subfamily B,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TCATAGGCCATTGAGGCCAAC	0.512			NA											17	39					0	0	0.00499	0	0
B3GNT1	11041	broad.mit.edu	37	11	66113531	66113531	+	Silent	SNP	G	G	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr11:66113531G>T	uc001ohr.2	-	2	1382	c.1237C>A	c.(1237-1239)CGA>AGA	p.R413R	BRMS1_uc001ohp.1_5'Flank|BRMS1_uc001oho.1_5'Flank	NM_006876	NP_006867	O43505	B3GN1_HUMAN	UDP-GlcNAc:betaGal	413	Lumenal (Potential).				poly-N-acetyllactosamine biosynthetic process	integral to Golgi membrane	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity				0						CAGCAGCGTCGGGGAGAGTTG	0.522			NA											35	112					9.62906e-15	1.17059e-14	0.00623	1	0
DRD2	1813	broad.mit.edu	37	11	113288792	113288792	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr11:113288792A>G	uc001pnz.2	-	2	673	c.352T>C	c.(352-354)TGC>CGC	p.C118R	DRD2_uc010rwv.1_Missense_Mutation_p.C117R|DRD2_uc001poa.3_Missense_Mutation_p.C118R|DRD2_uc001pob.3_Missense_Mutation_p.C118R|DRD2_uc009yyr.1_Missense_Mutation_p.C118R	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	118	Helical; Name=3; (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	CTCGCCGTGCACATCATGACG	0.552			NA											8	29					0	0	0.006214	0	0
HTR3B	9177	broad.mit.edu	37	11	113813798	113813798	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr11:113813798C>A	uc001pok.2	+	7	858	c.791C>A	c.(790-792)CCA>CAA	p.P264Q	HTR3B_uc001pol.2_Missense_Mutation_p.P253Q	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	264	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		TTCTACCTGCCACCCAACTGC	0.587			NA											11	20					0.00136819	0.00145005	0.013537	1	0
Unknown	0	broad.mit.edu	37	12	31267720	31267720	+	Silent	SNP	A	A	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr12:31267720A>G	uc010sjy.1	-	30	4149	c.4149T>C	c.(4147-4149)TAT>TAC	p.Y1383Y	uc001rjy.2_Intron|uc001rjz.2_Intron					RecName: Full=Ovostatin homolog 1; Flags: Precursor;												NA						TTTTATCTTTATACTCTATGT	0.318			NA											12	9					0	0	0.010729	0	0
C12orf61	283416	broad.mit.edu	37	12	62996808	62996808	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr12:62996808G>C	uc001sri.1	-	1	407	c.311C>G	c.(310-312)CCC>CGC	p.P104R	MIRLET7I_hsa-let-7i|MI0000434_5'Flank|uc001srj.1_5'Flank	NM_175895	NP_787091	Q8N7H1	CL061_HUMAN	hypothetical protein LOC283416	104											0			BRCA - Breast invasive adenocarcinoma(9;0.0399)	GBM - Glioblastoma multiforme(28;0.134)		GGGTGGCCTGGGGACTTCCCG	0.662			NA											5	8					0	0	0.000602	0	0
KCNMB4	27345	broad.mit.edu	37	12	70794043	70794043	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr12:70794043A>G	uc001svx.2	+	2	844	c.391A>G	c.(391-393)ATG>GTG	p.M131V		NM_014505	NP_055320	Q86W47	KCMB4_HUMAN	calcium-activated potassium channel beta 4	131	Extracellular (Potential).				detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of neurotransmitter secretion|regulation of vasoconstriction|synaptic transmission	voltage-gated potassium channel complex	calcium-activated potassium channel activity|protein binding				0	Renal(347;0.236)		Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			GGAAAGTGTCATGAATTGGCA	0.348			NA											52	73					0	0	0.01441	0	0
Unknown	0	broad.mit.edu	37	12	80761504	80761504	+	Silent	SNP	A	A	C			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr12:80761504A>C	uc009zsg.1	+	8	709	c.108A>C	c.(106-108)TCA>TCC	p.S36S	uc001szd.2_Silent_p.S175S					RecName: Full=Uncharacterized protein C12orf64;												NA						TGAATTGTTCAAAAAAATGTG	0.328			NA											2	0					0	0	0.004672	0	0
MPHOSPH9	10198	broad.mit.edu	37	12	123687368	123687368	+	Silent	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr12:123687368G>A	uc001uel.2	-	6	1235	c.1128C>T	c.(1126-1128)AAC>AAT	p.N376N	MPHOSPH9_uc010tal.1_Intron|MPHOSPH9_uc010tam.1_RNA|MPHOSPH9_uc001uem.2_Intron	NM_022782	NP_073619	Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	376					M phase of mitotic cell cycle	centriole|Golgi membrane					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		TCCTACTTTCGTTTTGGAATG	0.403			NA											5	155					0	0	0.000602	0	0
POTEG	404785	broad.mit.edu	37	14	19553772	19553772	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr14:19553772C>T	uc001vuz.1	+	1	408	c.356C>T	c.(355-357)CCT>CTT	p.P119L	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	119										ovary(1)	1						AAAGTGGGCCCTTGGGGAGAC	0.597			NA											19	244					0	0	0.008871	0	0
OR6S1	341799	broad.mit.edu	37	14	21109020	21109020	+	Silent	SNP	C	C	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr14:21109020C>A	uc001vxv.1	-	1	831	c.831G>T	c.(829-831)GTG>GTT	p.V277V		NM_001001968	NP_001001968	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S,	277	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		TTATTACTGTCACTGCCCAGT	0.458			NA											44	58					4.67007e-22	5.84937e-22	0.00874	1	0
RALGAPA1	253959	broad.mit.edu	37	14	36159051	36159051	+	Nonsense_Mutation	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr14:36159051G>A	uc001wti.2	-	17	2816	c.2425C>T	c.(2425-2427)CGA>TGA	p.R809*	RALGAPA1_uc001wtj.2_Nonsense_Mutation_p.R809*|RALGAPA1_uc010tpv.1_Nonsense_Mutation_p.R809*|RALGAPA1_uc010tpw.1_Nonsense_Mutation_p.R856*|RALGAPA1_uc001wtk.1_Nonsense_Mutation_p.R707*	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	809					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						CCTTTGGCTCGTTCAACAGTG	0.458			NA											37	24					0	0	0.007835	0	0
MDGA2	161357	broad.mit.edu	37	14	47600918	47600918	+	Silent	SNP	T	T	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr14:47600918T>A	uc001wwj.3	-	5	913	c.717A>T	c.(715-717)ACA>ACT	p.T239T	MDGA2_uc001wwi.3_Silent_p.T10T|MDGA2_uc010ani.2_5'UTR	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	239					spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						ATTCCATACCTGTTTTATTGG	0.328			NA											15	10					0	0	0.006122	0	0
SYNE2	23224	broad.mit.edu	37	14	64449507	64449507	+	Nonsense_Mutation	SNP	C	C	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr14:64449507C>T	uc001xgm.2	+	17	2226	c.1996C>T	c.(1996-1998)CAA>TAA	p.Q666*	SYNE2_uc001xgl.2_Nonsense_Mutation_p.Q666*	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	666	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTCAAAAACTCAACTTGTAAG	0.219			NA											21	22					0	0	0.014323	0	0
DICER1	23405	broad.mit.edu	37	14	95578531	95578531	+	Silent	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr14:95578531G>A	uc001ydw.2	-	14	2276	c.2094C>T	c.(2092-2094)TGC>TGT	p.C698C	DICER1_uc001ydv.2_Silent_p.C688C|DICER1_uc001ydx.2_Silent_p.C698C	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	698	Dicer dsRNA-binding fold.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		GTTTCTCACAGCAAATGAGAG	0.343			NA	Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				3	53					0	0	0.009096	0	0
AHNAK2	113146	broad.mit.edu	37	14	105409159	105409159	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr14:105409159G>A	uc010axc.1	-	7	12749	c.12629C>T	c.(12628-12630)GCC>GTC	p.A4210V	AHNAK2_uc001ypx.2_Missense_Mutation_p.A4110V	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4210						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TTTGAGGCCGGCTCCCTTGGG	0.642			NA											4	125					0	0	0.009096	0	0
TTBK2	146057	broad.mit.edu	37	15	43069415	43069415	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr15:43069415T>C	uc001zqo.2	-	12	1662	c.1223A>G	c.(1222-1224)CAT>CGT	p.H408R	TTBK2_uc010bcy.2_Missense_Mutation_p.H339R|TTBK2_uc001zqp.2_Missense_Mutation_p.H408R|TTBK2_uc010bcz.1_Missense_Mutation_p.H373R	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	408					cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		TGCCTGGCCATGGCTGTTCTC	0.443			NA											19	13					0	0	0.010504	0	0
ACAN	176	broad.mit.edu	37	15	89417108	89417108	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr15:89417108A>G	uc010upo.1	+	17	7743	c.7369A>G	c.(7369-7371)AGG>GGG	p.R2457G	ACAN_uc010upp.1_Intron|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	2457					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GGAGCATGCCAGGACCTTCGG	0.587			NA											11	15					0	0	0.013537	0	0
CHD9	80205	broad.mit.edu	37	16	53358590	53358590	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr16:53358590A>T	uc002ehb.2	+	38	8641	c.8477A>T	c.(8476-8478)GAT>GTT	p.D2826V	CHD9_uc002egy.2_Missense_Mutation_p.D2810V|CHD9_uc002ehc.2_Missense_Mutation_p.D2811V|CHD9_uc002ehf.2_Missense_Mutation_p.D1924V|CHD9_uc010cbw.2_Missense_Mutation_p.D892V	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2826					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				AATACTTTTGATGTACAAAAC	0.368			NA											10	12					0	0	0.008291	0	0
NUDT7	283927	broad.mit.edu	37	16	77775669	77775669	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr16:77775669C>G	uc010chd.2	+	4	608	c.539C>G	c.(538-540)CCT>CGT	p.P180R	NUDT7_uc010vnj.1_Missense_Mutation_p.P127R	NM_001105663	NP_001099133	P0C024	NUDT7_HUMAN	nudix motif 7	180					nucleoside diphosphate metabolic process	peroxisome	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|magnesium ion binding|manganese ion binding			ovary(1)|kidney(1)	2						TACACAAACCCTGAAGACGGT	0.453			NA											19	30					0	0	0.007413	0	0
MVD	4597	broad.mit.edu	37	16	88721708	88721708	+	Missense_Mutation	SNP	T	T	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr16:88721708T>G	uc002flg.1	-	7	803	c.796A>C	c.(796-798)ACC>CCC	p.T266P	MVD_uc002flf.1_Missense_Mutation_p.T135P	NM_002461	NP_002452	P53602	MVD1_HUMAN	diphosphomevalonate decarboxylase	266					cholesterol biosynthetic process|positive regulation of cell proliferation	cytosol	ATP binding|diphosphomevalonate decarboxylase activity|Hsp70 protein binding|kinase activity|protein homodimerization activity				0				BRCA - Breast invasive adenocarcinoma(80;0.0478)		TCGAGGCAGGTGGCGTGGAAC	0.647			NA											4	10					0	0	0.009096	0	0
C16orf7	9605	broad.mit.edu	37	16	89775334	89775334	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr16:89775334G>A	uc002fom.1	-	13	1753	c.1628C>T	c.(1627-1629)GCG>GTG	p.A543V	C16orf7_uc002fol.1_Missense_Mutation_p.A473V|uc002fon.1_5'Flank	NM_004913	NP_004904	Q9Y2B5	CP007_HUMAN	chromosome 16 open reading frame 7	543	VPS9.				ATP synthesis coupled proton transport		GTPase activator activity|transporter activity				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GTAGTCTTCCGCACAGACACA	0.682			NA											6	5					0	0	0.001984	0	0
TP53	7157	broad.mit.edu	37	17	7578403	7578403	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr17:7578403C>A	uc002gim.2	-	5	721	c.527G>T	c.(526-528)TGC>TTC	p.C176F	TP53_uc002gig.1_Missense_Mutation_p.C176F|TP53_uc002gih.2_Missense_Mutation_p.C176F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C44F|TP53_uc010cng.1_Missense_Mutation_p.C44F|TP53_uc002gii.1_Missense_Mutation_p.C44F|TP53_uc010cnh.1_Missense_Mutation_p.C176F|TP53_uc010cni.1_Missense_Mutation_p.C176F|TP53_uc002gij.2_Missense_Mutation_p.C176F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C83F|TP53_uc002gio.2_Missense_Mutation_p.C44F|TP53_uc010vug.1_Missense_Mutation_p.C137F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	176	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	CP -> FS (in a sporadic cancer; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C176F(102)|p.C176Y(56)|p.C176S(19)|p.C176W(11)|p.C176R(8)|p.C176fs*71(7)|p.0?(7)|p.C176*(6)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.C176G(3)|p.C176fs*5(3)|p.R175_E180delRCPHHE(3)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.C176fs*65(1)|p.C176_P177delCP(1)|p.V173fs*69(1)|p.C176fs*68(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.C44Y(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R42fs*24(1)|p.C83Y(1)|p.C176fs*72(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R174fs*70(1)|p.C176del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.C176fs*6(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGTGGGGGCAGCGCCTCAC	0.652	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			31	16					3.1745e-13	3.82172e-13	0.008361	1	0
Unknown	0	broad.mit.edu	37	17	16734453	16734453	+	Nonstop_Mutation	SNP	C	C	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr17:16734453C>G	uc010vwr.1	-	4	1008	c.566G>C	c.(565-567)TGA>TCA	p.*189S						SubName: Full=cDNA FLJ53570, highly similar to Keratin, type I cytoskeletal 16;												NA						CCACCTTGCTCAGGAACCAGG	0.612			NA											6	9					0	0	0.001984	0	0
Unknown	0	broad.mit.edu	37	17	16734472	16734472	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr17:16734472C>G	uc010vwr.1	-	4	989	c.547G>C	c.(547-549)GAT>CAT	p.D183H						SubName: Full=cDNA FLJ53570, highly similar to Keratin, type I cytoskeletal 16;												NA						GGCCCAGCATCTCTGTGGTTG	0.607			NA											6	12					0	0	0.00308	0	0
SMARCE1	6605	broad.mit.edu	37	17	38787102	38787102	+	Silent	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr17:38787102G>A	uc002hux.2	-	10	1015	c.891C>T	c.(889-891)CGC>CGT	p.R297R	SMARCE1_uc010wff.1_Silent_p.R262R|SMARCE1_uc010wfg.1_Silent_p.R227R|SMARCE1_uc002huy.2_Silent_p.R262R|SMARCE1_uc010wfh.1_Silent_p.R227R|SMARCE1_uc010wfi.1_Silent_p.R279R	NM_003079	NP_003070	Q969G3	SMCE1_HUMAN	SWI/SNF-related matrix-associated	297	Potential.				chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity				0		Breast(137;0.000812)				CCTGCCTTTTGCGGGCCTGTT	0.512			NA											84	53					0	0	0.01441	0	0
CALCOCO2	10241	broad.mit.edu	37	17	46940221	46940221	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr17:46940221A>G	uc002iof.2	+	13	1274	c.1195A>G	c.(1195-1197)ATC>GTC	p.I399V	CALCOCO2_uc010wlp.1_Missense_Mutation_p.I420V|CALCOCO2_uc010wlq.1_Missense_Mutation_p.I327V|CALCOCO2_uc010wlr.1_Missense_Mutation_p.I423V|CALCOCO2_uc010wls.1_Missense_Mutation_p.I357V	NM_005831	NP_005822	Q13137	CACO2_HUMAN	calcium binding and coiled-coil domain 2	399	Interaction with MYO6.				response to interferon-gamma|viral reproduction	cytoskeleton|Golgi apparatus|nucleus|perinuclear region of cytoplasm|soluble fraction	protein homodimerization activity			ovary(1)	1						GAAATGCCCTATCTGCAAAGC	0.343			NA											73	27					0	0	0.01441	0	0
GRIN2C	2905	broad.mit.edu	37	17	72846773	72846773	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr17:72846773A>G	uc002jlt.1	-	5	1403	c.1247T>C	c.(1246-1248)GTG>GCG	p.V416A	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Missense_Mutation_p.V416A|GRIN2C_uc002jlv.1_3'UTR	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	416	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	AGGGCTCTCCACGATGACAAA	0.657			NA											36	35					0	0	0.004289	0	0
OR7G3	390883	broad.mit.edu	37	19	9237500	9237500	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr19:9237500G>C	uc010xkl.1	-	1	127	c.127C>G	c.(127-129)CTG>GTG	p.L43V		NM_001001958	NP_001001958	Q8NG95	OR7G3_HUMAN	olfactory receptor, family 7, subfamily G,	43	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATGATGAGCAGGTTCCCCAGC	0.547			NA											14	20					0	0	0.003163	0	0
KEAP1	9817	broad.mit.edu	37	19	10602335	10602335	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr19:10602335G>A	uc002moq.1	-	3	1399	c.1243C>T	c.(1243-1245)CGC>TGC	p.R415C	KEAP1_uc002mop.1_Missense_Mutation_p.R133C|KEAP1_uc002mor.1_Missense_Mutation_p.R415C	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	415	Kelch 2.			R->A: Loss of interaction with NFE2L2. Abolishes repression of NFE2L2-dependent gene expression. Loss of interaction with PGAM5.	regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			ACCCCGATGCGGTTACGGGGC	0.657			NA											8	8					0	0	0.004482	0	0
PAK4	10298	broad.mit.edu	37	19	39660357	39660357	+	Missense_Mutation	SNP	A	A	C	rs112229040		TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr19:39660357A>C	uc002okj.1	+	4	625	c.164A>C	c.(163-165)GAC>GCC	p.D55A	PAK4_uc002okl.1_Missense_Mutation_p.D55A|PAK4_uc002okn.1_Missense_Mutation_p.D55A|PAK4_uc002okm.1_Missense_Mutation_p.D55A|PAK4_uc002oko.1_Missense_Mutation_p.D55A|PAK4_uc002okp.1_Missense_Mutation_p.D55A	NM_001014831	NP_001014831	O96013	PAK4_HUMAN	p21-activated kinase 4 isoform 1	55	Linker.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)			CCCCTCGTCGACCCCGCCTGC	0.716			NA											6	11					0	0	0.001855	0	0
ITSN2	50618	broad.mit.edu	37	2	24432687	24432687	+	Silent	SNP	C	C	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr2:24432687C>T	uc002rfe.2	-	35	4731	c.4473G>A	c.(4471-4473)ACG>ACA	p.T1491T	ITSN2_uc002rff.2_Silent_p.T1464T	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	1491	PH.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGATACTCACCGTTTTATACA	0.502			NA											23	63					0	0	0.014323	0	0
EML4	27436	broad.mit.edu	37	2	42552612	42552612	+	Silent	SNP	T	T	C			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr2:42552612T>C	uc002rsi.2	+	20	2422	c.2160T>C	c.(2158-2160)CAT>CAC	p.H720H	EML4_uc010fap.2_Silent_p.H662H|EML4_uc002rsj.2_Silent_p.H409H|EML4_uc010faq.2_Silent_p.H65H|EML4_uc010ynv.1_5'UTR	NM_019063	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	720	WD 8.				microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250						TCTAGGGACATTCCAGCTACA	0.348			NA	T	ALK	NSCLC								3	10					0	0	0.004672	0	0
PRKCE	5581	broad.mit.edu	37	2	46411986	46411986	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr2:46411986G>T	uc002rut.2	+	15	2377	c.2180G>T	c.(2179-2181)GGT>GTT	p.G727V		NM_005400	NP_005391	Q02156	KPCE_HUMAN	protein kinase C, epsilon	727	AGC-kinase C-terminal.				activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity			lung(4)|ovary(3)|kidney(1)|breast(1)|large_intestine(1)	10		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			GAATTCAAAGGTTTCTCCTAC	0.498			NA											25	40					4.26978e-12	4.99483e-12	0.00333	1	0
REG1B	5968	broad.mit.edu	37	2	79314689	79314689	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr2:79314689A>G	uc002sny.2	-	2	162	c.50T>C	c.(49-51)CTG>CCG	p.L17P	REG1B_uc010ffv.1_Missense_Mutation_p.L17P|REG1B_uc010ffw.2_Missense_Mutation_p.L17P	NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	17					cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|skin(1)	2						GCTCAGAGACAGGAACATCAG	0.468			NA											9	27					0	0	0.004482	0	0
MAL	4118	broad.mit.edu	37	2	95715324	95715324	+	Splice_Site	SNP	A	A	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr2:95715324A>G	uc002stx.1	+	3	321	c.262_splice	c.e3-2	p.D88_splice	MAL_uc002sty.1_Splice_Site_p.D32_splice|MAL_uc002stz.1_Intron|MAL_uc002sua.1_Intron	NM_002371	NP_002362	P21145	MAL_HUMAN	T-lymphocyte maturation-associated protein						apical protein localization|cell differentiation|central nervous system development|induction of apoptosis|membrane raft polarization|myelination	apical plasma membrane|endoplasmic reticulum|endosome|integral to plasma membrane|membrane raft	apoptotic protease activator activity|channel activity|lipid binding|structural constituent of myelin sheath				0				STAD - Stomach adenocarcinoma(1183;0.18)		TCTGCCCCATAGGACGCAGCC	0.657			NA											21	33					0	0	0.00333	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105883921	105883921	+	Silent	SNP	T	T	C			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr2:105883921T>C	uc002tcq.2	-	12	2586	c.2502A>G	c.(2500-2502)CCA>CCG	p.P834P	TGFBRAP1_uc010fjc.2_Silent_p.P603P|TGFBRAP1_uc002tcr.3_Silent_p.P834P|uc002tcp.2_5'Flank	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	834					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						GACCACCATTTGGGTATCTAA	0.493	Esophageal Squamous(183;794 2019 9730 21801 48859)		NA											42	53					0	0	0.009718	0	0
ABCA12	26154	broad.mit.edu	37	2	215862422	215862422	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr2:215862422A>T	uc002vew.2	-	23	3511	c.3291T>A	c.(3289-3291)CAT>CAA	p.H1097Q	ABCA12_uc002vev.2_Missense_Mutation_p.H779Q|ABCA12_uc010zjn.1_Missense_Mutation_p.H24Q	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1097					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AACATACCTCATGAAGCCGGA	0.358	Ovarian(66;664 1488 5121 34295)		NA											27	17					0	0	0.003954	0	0
SCG2	7857	broad.mit.edu	37	2	224462881	224462881	+	Missense_Mutation	SNP	T	T	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr2:224462881T>G	uc002vnm.2	-	2	1253	c.1120A>C	c.(1120-1122)AAG>CAG	p.K374Q		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	374					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		CCATTCGGCTTCTCCCCAGTT	0.453			NA											42	39					0	0	0.006999	0	0
USP40	55230	broad.mit.edu	37	2	234394527	234394527	+	Silent	SNP	C	C	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr2:234394527C>T	uc010zmr.1	-	28	3327	c.3327G>A	c.(3325-3327)GGG>GGA	p.G1109G	USP40_uc002vul.2_Silent_p.G93G|USP40_uc010zms.1_Silent_p.G207G	NM_018218	NP_060688	Q9NVE5	UBP40_HUMAN	ubiquitin thioesterase 40	1097					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)|breast(1)	3		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		AGCCGGCAGTCCCACCCTGGG	0.592			NA											8	2					0	0	0.00308	0	0
PRND	23627	broad.mit.edu	37	20	4705263	4705263	+	Silent	SNP	T	T	C			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr20:4705263T>C	uc002wkz.2	+	2	137	c.66T>C	c.(64-66)TCT>TCC	p.S22S		NM_012409	NP_036541	Q9UKY0	PRND_HUMAN	prion-like protein doppel preproprotein	22			S -> P.		protein homooligomerization	anchored to membrane|plasma membrane					0						GCCACCTCTCTGCGGTCCAGA	0.627			NA											22	21					0	0	0.010504	0	0
PPP1R3D	5509	broad.mit.edu	37	20	58514506	58514506	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr20:58514506G>A	uc002ybb.2	-	1	847	c.481C>T	c.(481-483)CCG>TCG	p.P161S	C20orf177_uc002yba.2_Intron|C20orf177_uc010zzx.1_5'Flank|C20orf177_uc002ybc.2_5'Flank	NM_006242	NP_006233	O95685	PPR3D_HUMAN	protein phosphatase 1, regulatory subunit 3D	161					glycogen metabolic process		protein binding|protein serine/threonine phosphatase activity				0	all_lung(29;0.00391)		BRCA - Breast invasive adenocarcinoma(7;5.12e-09)			TCGACGGGCGGCGGGAAATCG	0.677			NA											3	11					0	0	0.004672	0	0
TFIP11	24144	broad.mit.edu	37	22	26892780	26892780	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr22:26892780C>T	uc003acr.2	-	10	1886	c.1512G>A	c.(1510-1512)ATG>ATA	p.M504I	TFIP11_uc003acq.2_5'Flank|TFIP11_uc003acs.2_Missense_Mutation_p.M504I|TFIP11_uc003act.2_Missense_Mutation_p.M504I	NM_012143	NP_036275	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	504					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity				0						AAAAGTCCACCATCGGGTCAC	0.478			NA											11	80					0	0	0.010729	0	0
NCAPH2	29781	broad.mit.edu	37	22	50961504	50961504	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr22:50961504C>T	uc003blr.3	+	19	1708	c.1586C>T	c.(1585-1587)CCC>CTC	p.P529L	NCAPH2_uc003blv.2_Missense_Mutation_p.P529L|NCAPH2_uc010hbb.2_Intron|NCAPH2_uc003blu.3_RNA|NCAPH2_uc003bls.3_RNA|NCAPH2_uc003blt.3_RNA|NCAPH2_uc003blw.3_RNA|NCAPH2_uc003blx.3_Missense_Mutation_p.P530L|NCAPH2_uc003bly.3_RNA	NM_152299	NP_689512	Q6IBW4	CNDH2_HUMAN	kleisin beta isoform 2	529					chromosome condensation	chromosome|nucleus				ovary(1)|skin(1)	2		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		TCACGGTTCCCCCAGCTCAAT	0.632			NA											8	6					0	0	0.00308	0	0
SETD2	29072	broad.mit.edu	37	3	47158225	47158225	+	Nonsense_Mutation	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr3:47158225G>A	uc003cqs.2	-	4	4527	c.4474C>T	c.(4474-4476)CGA>TGA	p.R1492*	SETD2_uc003cqv.2_Nonsense_Mutation_p.R1481*	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1492					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding	p.R989*(1)		kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TTAATATCTCGATGAGATTTA	0.313			NA	N|F|S|Mis		clear cell renal carcinoma								17	25					0	0	0.00499	0	0
ARHGAP24	83478	broad.mit.edu	37	4	86491836	86491836	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr4:86491836C>T	uc003hpk.2	+	2	591	c.142C>T	c.(142-144)CTC>TTC	p.L48F	ARHGAP24_uc003hpi.1_Missense_Mutation_p.L48F|ARHGAP24_uc003hpj.2_Missense_Mutation_p.L48F	NM_001025616	NP_001020787	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24 isoform 1	48	PH.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		GGGGGATCAGCTCTATTATTT	0.473			NA											20	23					0	0	0.00278	0	0
PPP3CA	5530	broad.mit.edu	37	4	101953470	101953470	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr4:101953470C>A	uc011cen.1	-	12	1968	c.1293G>T	c.(1291-1293)ATG>ATT	p.M431I	PPP3CA_uc003hvu.2_Missense_Mutation_p.M431I|PPP3CA_uc010ilj.2_Missense_Mutation_p.M389I|PPP3CA_uc003hvt.2_Missense_Mutation_p.M418I|PPP3CA_uc003hvs.2_Missense_Mutation_p.M364I|PPP3CA_uc010ilk.2_Missense_Mutation_p.M199I	NM_000944	NP_000935	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha	431					protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		CGCTGGGGAGCATGCCAGTTG	0.522			NA											9	12					0.000673444	0.000726148	0.008291	1	0
ANK2	287	broad.mit.edu	37	4	114209548	114209548	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr4:114209548G>T	uc003ibe.3	+	20	2283	c.2183G>T	c.(2182-2184)GGT>GTT	p.G728V	ANK2_uc003ibd.3_Missense_Mutation_p.G707V|ANK2_uc003ibf.3_Missense_Mutation_p.G728V|ANK2_uc003ibc.2_Missense_Mutation_p.G704V|ANK2_uc011cgb.1_Missense_Mutation_p.G743V	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	728	ANK 22.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TTACAGCTTGGTTACACACCT	0.358			NA											31	32					1.61788e-16	1.98631e-16	0.012213	1	0
NPY1R	4886	broad.mit.edu	37	4	164247323	164247323	+	Missense_Mutation	SNP	A	A	C			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr4:164247323A>C	uc003iqm.1	-	2	650	c.384T>G	c.(382-384)ATT>ATG	p.I128M	NPY1R_uc011cjj.1_Intron	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	128	Helical; Name=3; (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CCAGAGAGAAAATGGACACAG	0.423			NA											12	61					0	0	0.010729	0	0
TRIM60	166655	broad.mit.edu	37	4	165962548	165962548	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr4:165962548G>T	uc003iqy.1	+	3	1494	c.1324G>T	c.(1324-1326)GAT>TAT	p.D442Y	TRIM60_uc010iqx.1_Missense_Mutation_p.D442Y	NM_152620	NP_689833	Q495X7	TRI60_HUMAN	ring finger protein 129	442	B30.2/SPRY.					intracellular	zinc ion binding			skin(1)	1	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		TACTTTTAACGATTGTTTCAC	0.343			NA											33	29					5.60225e-13	6.6796e-13	0.009535	1	0
PLEKHG4B	153478	broad.mit.edu	37	5	144977	144977	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr5:144977T>C	uc003jak.2	+	4	829	c.779T>C	c.(778-780)GTG>GCG	p.V260A		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	260					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GTTGTCCTGGTGGATGCACGC	0.567			NA											16	36					0	0	0.004007	0	0
SPEF2	79925	broad.mit.edu	37	5	35670182	35670182	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr5:35670182G>T	uc003jjo.2	+	10	1488	c.1377G>T	c.(1375-1377)ATG>ATT	p.M459I	SPEF2_uc003jjn.1_Missense_Mutation_p.M459I|SPEF2_uc003jjq.3_Missense_Mutation_p.M459I	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	459					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ATAAGTTGATGCATGATTGGA	0.323			NA											25	64					6.36457e-07	7.10998e-07	0.003954	1	0
FBXL17	64839	broad.mit.edu	37	5	107700656	107700656	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr5:107700656T>C	uc011cvc.1	-	3	1564	c.1157A>G	c.(1156-1158)CAG>CGG	p.Q386R	FBXL17_uc003kon.3_5'UTR	NM_001163315	NP_001156787	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	386											0		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		AATTATATTCTGACTTCTTGA	0.308			NA											18	28					0	0	0.007413	0	0
SRP19	6728	broad.mit.edu	37	5	112228539	112228539	+	Silent	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr5:112228539G>A	uc011cvv.1	+	4	1533	c.1278G>A	c.(1276-1278)GAG>GAA	p.E426E	SRP19_uc011cvu.1_Silent_p.E411E|REEP5_uc011cvw.1_Intron|REEP5_uc003kqe.1_Intron|REEP5_uc011cvx.1_Intron|REEP5_uc011cvy.1_Intron|REEP5_uc011cvz.1_Intron			P09132	SRP19_HUMAN	SubName: Full=Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2;	Error:Variant_position_missing_in_P09132_after_alignment					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|mitochondrion|nucleolus|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding				0		all_cancers(142;0.00328)|all_epithelial(76;6.39e-05)|Prostate(80;0.00174)|Colorectal(10;0.00372)|Ovarian(225;0.156)		Epithelial(69;1.7e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.17e-08)|all cancers(49;3.96e-07)|Colorectal(14;0.0056)|COAD - Colon adenocarcinoma(37;0.0104)		GGGAATCCGAGAGAAAAAAGA	0.512			NA											6	11					0	0	0.001168	0	0
PGBD1	84547	broad.mit.edu	37	6	28253402	28253402	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr6:28253402G>T	uc003nky.2	+	3	841	c.471G>T	c.(469-471)CAG>CAT	p.Q157H	PGBD1_uc003nkz.2_Missense_Mutation_p.Q157H	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	157					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						TGGAGTGTCAGAGCCTCCAGC	0.502			NA											18	24					2.4624e-09	2.8272e-09	0.008871	1	0
UHRF1BP1	54887	broad.mit.edu	37	6	34802533	34802533	+	Silent	SNP	C	C	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr6:34802533C>T	uc003oju.3	+	6	798	c.564C>T	c.(562-564)CTC>CTT	p.L188L	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	188										ovary(3)	3						GGCAAACACTCCGAATTGAGG	0.423			NA											49	60					0	0	0.01441	0	0
TCTE1	202500	broad.mit.edu	37	6	44250206	44250206	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr6:44250206C>G	uc003oxi.2	-	4	1093	c.937G>C	c.(937-939)GAC>CAC	p.D313H	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	313	LRR 1.									ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TGTGACAAGTCCAGCTCCTCG	0.567			NA											22	17					0	0	0.012319	0	0
KIAA1009	22832	broad.mit.edu	37	6	84862734	84862734	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr6:84862734T>A	uc010kbp.2	-	23	3256	c.3159A>T	c.(3157-3159)AAA>AAT	p.K1053N	KIAA1009_uc003pkj.3_Missense_Mutation_p.K977N|KIAA1009_uc003pki.3_Missense_Mutation_p.K439N	NM_014895	NP_055710	Q5TB80	QN1_HUMAN	KIAA1009 protein	1053	Potential.				cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			ovary(1)	1		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		CATTCTGATGTTTAAGAACGT	0.383			NA											15	18					0	0	0.004007	0	0
PLG	5340	broad.mit.edu	37	6	161162365	161162365	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr6:161162365G>T	uc003qtm.3	+	17	2104	c.2041G>T	c.(2041-2043)GTA>TTA	p.V681L		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	681	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CACTGACAAAGTAATCCCAGC	0.493			NA											26	18					7.01153e-11	8.12552e-11	0.007291	1	0
MYL10	93408	broad.mit.edu	37	7	101266291	101266291	+	Missense_Mutation	SNP	G	G	T	rs144539367	byFrequency	TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr7:101266291G>T	uc003uyr.2	-	4	513	c.335C>A	c.(334-336)ACC>AAC	p.T112N		NM_138403	NP_612412	Q9BUA6	MYL10_HUMAN	myosin, light chain 10, regulatory	112	EF-hand 1.					mitochondrion	calcium ion binding			ovary(1)|breast(1)	2						CGCGGCAAAGGTGTCCCTCAA	0.627	Esophageal Squamous(24;575 709 17516 40384 51639)		NA											12	21					7.93312e-07	8.7831e-07	0.00245	1	0
FEZF1	389549	broad.mit.edu	37	7	121942893	121942893	+	Silent	SNP	C	C	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr7:121942893C>T	uc003vkd.2	-	3	1103	c.1029G>A	c.(1027-1029)CCG>CCA	p.P343P	FEZF1_uc003vkc.2_Silent_p.P293P|uc010lko.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	343					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						CACACACAAACGGTTTGTAGC	0.393			NA											51	129					0	0	0.01441	0	0
KIAA1549	57670	broad.mit.edu	37	7	138554409	138554409	+	Silent	SNP	T	T	C			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr7:138554409T>C	uc011kql.1	-	14	4699	c.4650A>G	c.(4648-4650)GTA>GTG	p.V1550V	KIAA1549_uc011kqi.1_Silent_p.V334V|KIAA1549_uc003vuk.3_Silent_p.V1500V|KIAA1549_uc011kqj.1_Silent_p.V1550V|KIAA1549_uc011kqk.1_Silent_p.V334V	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	1550						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						ACAGGTCGTCTACCACCGGGA	0.642	NSCLC(119;1534 1718 44213 46230 50068)		NA	O	BRAF	pilocytic astrocytoma								5	22					0	0	0.00308	0	0
TRPV5	56302	broad.mit.edu	37	7	142605736	142605736	+	Silent	SNP	A	A	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr7:142605736A>G	uc003wby.1	-	15	2398	c.2134T>C	c.(2134-2136)TTG>CTG	p.L712L		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	712	Cytoplasmic (Potential).|Involved in Ca(2+)-dependent inactivation (By similarity).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					CCAAGATTCAAGTGCCCCAGG	0.552			NA											27	46					0	0	0.008361	0	0
PTK2B	2185	broad.mit.edu	37	8	27255117	27255117	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr8:27255117G>A	uc003xfn.1	+	7	824	c.16G>A	c.(16-18)GAG>AAG	p.E6K	PTK2B_uc003xfo.1_Missense_Mutation_p.E6K|PTK2B_uc003xfp.1_Missense_Mutation_p.E6K|PTK2B_uc003xfq.1_Missense_Mutation_p.E6K	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	6					apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		TGGGGTGTCCGAGCCCCTGAG	0.607			NA											10	42					0	0	0.00278	0	0
PURG	29942	broad.mit.edu	37	8	30890170	30890170	+	Silent	SNP	C	C	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr8:30890170C>T	uc003xin.2	-	1	148	c.129G>A	c.(127-129)GCG>GCA	p.A43A	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Silent_p.A43A	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	43						nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		TGGCTGAGGCCGCGTAGTGGG	0.532			NA											6	16					0	0	0.001168	0	0
RBM12B	389677	broad.mit.edu	37	8	94747222	94747222	+	Nonsense_Mutation	SNP	T	T	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr8:94747222T>A	uc003yfz.2	-	3	1610	c.1417A>T	c.(1417-1419)AGA>TGA	p.R473*		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	473	RRM 3.						nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GATATAAGTCTTAATAACACC	0.418			NA											96	175					0	0	0.01441	0	0
ESRP1	54845	broad.mit.edu	37	8	95680478	95680478	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr8:95680478G>C	uc003ygq.3	+	10	1416	c.1233G>C	c.(1231-1233)CAG>CAC	p.Q411H	ESRP1_uc003ygr.3_Missense_Mutation_p.Q411H|ESRP1_uc003ygs.3_Missense_Mutation_p.Q411H|ESRP1_uc003ygt.3_Missense_Mutation_p.Q411H|ESRP1_uc003ygu.3_Missense_Mutation_p.Q411H|ESRP1_uc003ygv.2_Missense_Mutation_p.Q251H|ESRP1_uc003ygw.2_Missense_Mutation_p.Q251H	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	411					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						AAGTTCAGCAGGTTGGTTTTA	0.368			NA											16	28					0	0	0.003163	0	0
CSMD3	114788	broad.mit.edu	37	8	113347698	113347699	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr8:113347698_113347699CC>AT	uc003ynu.2	-	45	7183_7184	c.7024_7025GG>AT	c.(7024-7026)GGA>ATA	p.G2342I	CSMD3_uc003yns.2_Missense_Mutation_p.G1544I|CSMD3_uc003ynt.2_Missense_Mutation_p.G2302I|CSMD3_uc011lhx.1_Missense_Mutation_p.G2238I|CSMD3_uc003ynw.1_Missense_Mutation_p.G53I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2342	Extracellular (Potential).|CUB 13.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTGGTCTGGTCCATCCCTATGA	0.371			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			15	18					0	0	0.004672	0	0
ZHX2	22882	broad.mit.edu	37	8	123964400	123964400	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr8:123964400G>T	uc003ypk.1	+	3	1217	c.650G>T	c.(649-651)CGC>CTC	p.R217L		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	217	Required for homodimerization.					cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			GGGACCGCCCGCCTGGTGACA	0.592	Esophageal Squamous(94;1056 1388 11767 13799 49639)		NA											26	73					1.50538e-07	1.69697e-07	0.00632	1	0
GSDMC	56169	broad.mit.edu	37	8	130764122	130764122	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr8:130764122T>C	uc003ysr.2	-	9	1784	c.902A>G	c.(901-903)CAC>CGC	p.H301R		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	301						mitochondrion				ovary(2)|skin(1)	3						TGGGAGGATGTGAACTTGTTC	0.498			NA											90	221					0	0	0.01441	0	0
SMARCA2	6595	broad.mit.edu	37	9	2056747	2056747	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr9:2056747C>T	uc003zhc.2	+	7	1348	c.1249C>T	c.(1249-1251)CGG>TGG	p.R417W	SMARCA2_uc003zhd.2_Missense_Mutation_p.R417W|SMARCA2_uc010mha.2_Missense_Mutation_p.R408W	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	417					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		AGCATACAAACGGAGCAAGCG	0.557			NA											11	12					0	0	0.008291	0	0
FREM1	158326	broad.mit.edu	37	9	14848694	14848694	+	Silent	SNP	A	A	G			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr9:14848694A>G	uc003zlm.2	-	7	1820	c.1230T>C	c.(1228-1230)GAT>GAC	p.D410D	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	410	CSPG 2.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		GGGCATTTGTATCTGCTGTTC	0.413			NA											32	31					0	0	0.013726	0	0
CNTLN	54875	broad.mit.edu	37	9	17415873	17415873	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr9:17415873A>T	uc003zmz.2	+	17	2907	c.2881A>T	c.(2881-2883)ACT>TCT	p.T961S	CNTLN_uc003zmy.2_Missense_Mutation_p.T962S|CNTLN_uc010mio.2_Missense_Mutation_p.T641S	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	962						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		AGCAGTTCCTACTAGAGGTAA	0.269			NA											24	24					0	0	0.003954	0	0
GABBR2	9568	broad.mit.edu	37	9	101068494	101068494	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr9:101068494G>A	uc004ays.2	-	15	2294	c.2138C>T	c.(2137-2139)ACC>ATC	p.T713I		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	713	Extracellular (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	CTGGTCCCGGGTCAGGAAGGA	0.577			NA											8	9					0	0	0.00308	0	0
MXRA5	25878	broad.mit.edu	37	X	3239235	3239235	+	Silent	SNP	G	G	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chrX:3239235G>A	uc004crg.3	-	5	4648	c.4491C>T	c.(4489-4491)TCC>TCT	p.S1497S		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1497						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TGAGAATTGTGGATGGGGACG	0.473			NA											49	32					0	0	0.01441	0	0
DMD	1756	broad.mit.edu	37	X	32613910	32613910	+	Silent	SNP	T	T	C			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chrX:32613910T>C	uc004dda.1	-	13	1810	c.1566A>G	c.(1564-1566)GGA>GGG	p.G522G	DMD_uc004dcz.2_Silent_p.G399G|DMD_uc004dcy.1_Silent_p.G518G|DMD_uc004ddb.1_Silent_p.G514G|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Silent_p.G514G|DMD_uc010ngp.1_Intron|DMD_uc010ngq.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	522	Spectrin 2.		Missing (in BMD).		muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTGCGTGATCTCCACTAGATT	0.353			NA											21	16					0	0	0.012319	0	0
SEPT6	23157	broad.mit.edu	37	X	118771105	118771105	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chrX:118771105C>A	uc004erv.2	-	7	1106	c.841G>T	c.(841-843)GTC>TTC	p.V281F	SEPT6_uc010nqk.2_Intron|SEPT6_uc004ers.2_Missense_Mutation_p.V281F|SEPT6_uc004ert.2_Missense_Mutation_p.V281F|SEPT6_uc004eru.2_Missense_Mutation_p.V281F|SEPT6_uc004erw.2_Missense_Mutation_p.V223F|SEPT6_uc011mtv.1_Missense_Mutation_p.V223F|SEPT6_uc011mtw.1_Missense_Mutation_p.V311F	NM_015129	NP_055944	Q14141	SEPT6_HUMAN	septin 6 isoform B	281					cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			lung(1)|ovary(1)|prostate(1)|kidney(1)	4						TCCATGTTGACCCGAATCAGC	0.547			NA											11	19					6.31663e-08	7.18589e-08	0.003163	1	0
XPNPEP2	7512	broad.mit.edu	37	X	128877985	128877985	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chrX:128877985C>T	uc004eut.1	+	3	416	c.172C>T	c.(172-174)CGC>TGC	p.R58C	XPNPEP2_uc011mum.1_Missense_Mutation_p.R58C	NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	58					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						CACAGCCCTCCGCCAGCAGAT	0.498			NA											9	86					0	0	0.006214	0	0
SAGE1	55511	broad.mit.edu	37	X	134990731	134990731	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chrX:134990731A>T	uc004ezh.2	+	12	1563	c.1396A>T	c.(1396-1398)AAT>TAT	p.N466Y	SAGE1_uc010nry.1_Missense_Mutation_p.N435Y|SAGE1_uc011mvv.1_Intron	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	466										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CGGGCTTATTAATATGGCAGG	0.413			NA											73	56					0	0	0.01441	0	0
GPR112	139378	broad.mit.edu	37	X	135430519	135430519	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chrX:135430519T>A	uc004ezu.1	+	6	4945	c.4654T>A	c.(4654-4656)TGT>AGT	p.C1552S	GPR112_uc010nsb.1_Missense_Mutation_p.C1347S|GPR112_uc010nsc.1_Missense_Mutation_p.C1319S	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1552	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.C1552Y(1)		ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					GAAAAGTCCCTGTACAGCCAC	0.418			NA											67	44					0	0	0.01441	0	0
SLITRK4	139065	broad.mit.edu	37	X	142716785	142716785	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chrX:142716785G>T	uc004fbx.2	-	2	2516	c.2140C>A	c.(2140-2142)CCT>ACT	p.P714T	SLITRK4_uc004fby.2_Missense_Mutation_p.P714T	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	714	Cytoplasmic (Potential).					integral to membrane		p.P714T(1)		upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TGTCCTGGAGGATCTGAAAAC	0.423			NA											61	40					2.44813e-32	3.09764e-32	0.01441	1	0
FGFR2	2263	broad.mit.edu	37	10	123324018	123324020	+	In_Frame_Del	DEL	TTG	TTG	-			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	TTG	TTG	-	-	TTG	TTG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr10:123324018_123324020delTTG	uc010qtk.1	-	4	1097_1099	c.450_452delCAA	c.(448-453)AACAAG>AAG	p.N150del	FGFR2_uc010qtg.1_In_Frame_Del_p.N150del|FGFR2_uc010qth.1_Intron|FGFR2_uc010qti.1_In_Frame_Del_p.N61del|FGFR2_uc010qtj.1_In_Frame_Del_p.N150del|FGFR2_uc010qtl.1_In_Frame_Del_p.N150del|FGFR2_uc010qtm.1_Intron|FGFR2_uc001lfl.3_In_Frame_Del_p.N150del|FGFR2_uc001lfm.2_In_Frame_Del_p.N61del|FGFR2_uc001lfn.3_Intron|FGFR2_uc010qtn.1_In_Frame_Del_p.N169del|FGFR2_uc010qto.1_Intron|FGFR2_uc001lfo.1_In_Frame_Del_p.N169del|FGFR2_uc010qtp.1_In_Frame_Del_p.N169del|FGFR2_uc010qtq.1_In_Frame_Del_p.N169del	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	150	Extracellular (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	TTACTTACTCTTGTTGTTACTGT	0.507			5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				20	93	---	---	---	---	NA	NA	NA	NA	NA
BUD13	84811	broad.mit.edu	37	11	116633839	116633839	+	Frame_Shift_Del	DEL	G	G	-			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr11:116633839delG	uc001ppn.2	-	4	500	c.466delC	c.(466-468)CGTfs	p.R156fs	BUD13_uc001ppo.2_Frame_Shift_Del_p.R156fs|BUD13_uc009yzc.2_Frame_Shift_Del_p.R156fs	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	156	Arg-rich.									large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		GTGTCATGACGGGCCCTCCTA	0.587			NA											52	110	---	---	---	---	NA	NA	NA	NA	NA
DACT1	51339	broad.mit.edu	37	14	59113753	59113753	+	Frame_Shift_Del	DEL	C	C	-			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr14:59113753delC	uc001xdw.2	+	4	2576	c.2412delC	c.(2410-2412)CACfs	p.H804fs	DACT1_uc010trv.1_Frame_Shift_Del_p.H523fs|DACT1_uc001xdx.2_Frame_Shift_Del_p.H767fs|DACT1_uc010trw.1_Frame_Shift_Del_p.H523fs	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	804					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						TTCACAACCACCCCGCAAAAA	0.502			NA											33	49	---	---	---	---	NA	NA	NA	NA	NA
NF1	4763	broad.mit.edu	37	17	29676209	29676209	+	Frame_Shift_Del	DEL	A	A	-			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr17:29676209delA	uc002hgg.2	+	49	7594	c.7261delA	c.(7261-7263)AACfs	p.N2421fs	NF1_uc002hgh.2_Frame_Shift_Del_p.N2400fs|NF1_uc010cso.2_Frame_Shift_Del_p.N609fs|NF1_uc010wbt.1_5'UTR|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2421					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AACTCTGGTTAACAAACACAG	0.313			NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			10	15	---	---	---	---	NA	NA	NA	NA	NA
PLXNB2	23654	broad.mit.edu	37	22	50718982	50718982	+	Frame_Shift_Del	DEL	T	T	-			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr22:50718982delT	uc003bkv.3	-	25	4217	c.4111delA	c.(4111-4113)ACGfs	p.T1371fs	PLXNB2_uc003bkt.1_Frame_Shift_Del_p.T163fs|PLXNB2_uc003bku.1_Frame_Shift_Del_p.T356fs	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1371	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AGGAAGAGCGTGTGCATGATG	0.532			NA											22	30	---	---	---	---	NA	NA	NA	NA	NA
TEX15	56154	broad.mit.edu	37	8	30701411	30701412	+	Frame_Shift_Ins	INS	-	-	T			TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr8:30701411_30701412insT	uc003xil.2	-	1	5122_5123	c.5122_5123insA	c.(5122-5124)AGGfs	p.R1708fs		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1708										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TTCTAAGTGCCTTTTTTTGTTT	0.376			NA											7	131	---	---	---	---	NA	NA	NA	NA	NA
RAD21	5885	broad.mit.edu	37	8	117869548	117869549	+	Frame_Shift_Del	DEL	TA	TA	-	rs143910582	by1000genomes	TCGA-73-4676-01A-01D-1753-08	TCGA-73-4676-11A-01D-1753-08	TA	TA	-	-	TA	TA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ff368c6d-fedb-49cc-b519-7726816aff8d	2660c208-3cf3-4408-9ed1-370cc3479648	g.chr8:117869548_117869549delTA	uc003yod.2	-	6	933_934	c.645_646delTA	c.(643-648)TATAAGfs	p.Y215fs		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	215_216					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					TTATCATCCTTATATTGATCTT	0.327			NA											48	86	---	---	---	---	NA	NA	NA	NA	NA
