Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MTOR	2475	broad.mit.edu	37	1	11182049	11182049	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:11182049C>G	uc001asd.2	-	48	6918	c.6797G>C	c.(6796-6798)CGC>CCC	p.R2266P	MTOR_uc001asc.2_Missense_Mutation_p.R471P	NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	2266	PI3K/PI4K.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						CAACATGATGCGATGCTCGAT	0.557			NA											5	23					0	0	0.001984	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12884901	12884901	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:12884901G>C	uc001auk.2	-	4	1406	c.1210C>G	c.(1210-1212)CAC>GAC	p.H404D		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	404											0						TGCCTTAAGTGCCTCACTTTC	0.502			NA											9	239					0	0	0.001855	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12884909	12884909	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:12884909T>C	uc001auk.2	-	4	1398	c.1202A>G	c.(1201-1203)AAA>AGA	p.K401R		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	401											0						GTGCCTCACTTTCTTCATCAG	0.498			NA											9	228					0	0	0.001855	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12884937	12884937	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:12884937C>T	uc001auk.2	-	4	1370	c.1174G>A	c.(1174-1176)GCT>ACT	p.A392T		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	392											0						CTAATTTGAGCAAATCTGCTC	0.502			NA											6	228					0	0	0.004482	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887653	12887653	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:12887653G>A	uc001auk.2	-	3	400	c.204C>T	c.(202-204)GTC>GTT	p.V68V		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	68											0						AGTTCTCACAGACATCCTGTA	0.448			NA											27	256					0	0	0.002836	0	0
LOC440563	440563	broad.mit.edu	37	1	13183415	13183415	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:13183415G>T	uc010obg.1	-	1	553	c.458C>A	c.(457-459)TCA>TAA	p.S153*		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	153						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						GCCCCTTCGTGAGGTGTTTCC	0.512			NA											23	492					3.08376e-08	4.37149e-08	0.00333	1	0
ZBTB17	7709	broad.mit.edu	37	1	16268907	16268907	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:16268907C>T	uc001axl.3	-	15	2286	c.2047G>A	c.(2047-2049)GTG>ATG	p.V683M	ZBTB17_uc010obq.1_Missense_Mutation_p.V600M|ZBTB17_uc010obr.1_Missense_Mutation_p.V690M|ZBTB17_uc010obs.1_Missense_Mutation_p.V607M	NM_003443	NP_003434	Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	683	Interaction with MYC.|Interaction with HCFC1.				negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGCTCCCACCGGCACCACT	0.642			NA											4	29					0	0	0.009096	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18808542	18808542	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:18808542C>T	uc001bax.2	+	1	1119	c.1067C>T	c.(1066-1068)TCC>TTC	p.S356F	KLHDC7A_uc009vpg.2_Missense_Mutation_p.S138F	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	356	Kelch 1.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCGTGGCCCTCCACCCGAGGC	0.687			NA											3	19					0	0	0.004672	0	0
EIF4G3	8672	broad.mit.edu	37	1	21177755	21177755	+	Missense_Mutation	SNP	C	C	A	rs34661194	byFrequency	TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:21177755C>A	uc001bec.2	-	23	3856	c.3600G>T	c.(3598-3600)GAG>GAT	p.E1200D	EIF4G3_uc010odi.1_Missense_Mutation_p.E804D|EIF4G3_uc010odj.1_Missense_Mutation_p.E1199D|EIF4G3_uc009vpz.2_Missense_Mutation_p.E920D|EIF4G3_uc001bed.2_Missense_Mutation_p.E1200D|EIF4G3_uc001bef.2_Missense_Mutation_p.E1236D|EIF4G3_uc001bee.2_Missense_Mutation_p.E1206D	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	1200					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TCTCACCTGACTCCCTTGTTT	0.443			NA											10	73					7.48243e-07	1.00996e-06	0.006214	1	0
CCDC21	64793	broad.mit.edu	37	1	26581979	26581979	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:26581979G>C	uc001bls.1	+	4	657	c.526G>C	c.(526-528)GCG>CCG	p.A176P	CCDC21_uc001blr.2_Missense_Mutation_p.A176P|CCDC21_uc010ofa.1_Missense_Mutation_p.A125P	NM_022778	NP_073615	Q6P2H3	CEP85_HUMAN	coiled-coil domain containing 21	176						centrosome|nucleolus|spindle pole					0		all_cancers(24;7e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.6e-26)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;9.48e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00155)|GBM - Glioblastoma multiforme(114;0.00917)|READ - Rectum adenocarcinoma(331;0.0649)		ACAAGAAGAGGCGAGGAAGTT	0.468			NA											5	72					0	0	0.000602	0	0
RCC1	1104	broad.mit.edu	37	1	28862433	28862433	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:28862433G>T	uc001bqg.1	+	7	797	c.712G>T	c.(712-714)GGC>TGC	p.G238C	SNHG3-RCC1_uc001bqa.1_Missense_Mutation_p.G238C|SNHG3-RCC1_uc001bqb.1_Missense_Mutation_p.G238C|SNHG3-RCC1_uc001bqc.1_Missense_Mutation_p.G238C|RCC1_uc001bqe.1_Missense_Mutation_p.G255C|RCC1_uc001bqf.1_Missense_Mutation_p.G269C	NM_001269	NP_001260	P18754	RCC1_HUMAN	regulator of chromosome condensation 1 isoform	238	RCC1 4.				cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		GGGAAGCCGGGGCCACGTGAG	0.562			NA											12	91					5.50884e-06	7.21985e-06	0.001368	1	0
ADPRHL2	54936	broad.mit.edu	37	1	36558117	36558117	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:36558117G>C	uc001bzt.2	+	5	849	c.796G>C	c.(796-798)GAG>CAG	p.E266Q	ADPRHL2_uc001bzu.2_Missense_Mutation_p.E112Q	NM_017825	NP_060295	Q9NX46	ARHL2_HUMAN	ADP-ribosylhydrolase like 2	266						cytoplasm|nucleus	metal ion binding|poly(ADP-ribose) glycohydrolase activity			pancreas(1)	1		Myeloproliferative disorder(586;0.0393)				AGTGGTGTCTGAGCTAGGTGA	0.597			NA											3	37					0	0	0.000602	0	0
MAP7D1	55700	broad.mit.edu	37	1	36640515	36640515	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:36640515C>T	uc001bzz.2	+	6	972	c.756C>T	c.(754-756)TCC>TCT	p.S252S	MAP7D1_uc001caa.2_Silent_p.S252S|MAP7D1_uc001cab.2_Intron|MAP7D1_uc001cac.2_5'UTR|MAP7D1_uc001cad.2_5'Flank	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	252						cytoplasm|spindle				ovary(3)|breast(2)	5		Myeloproliferative disorder(586;0.0393)				GCAGGTGCTCCGTGTCGGCAG	0.607			NA											3	28					0	0	0.004672	0	0
THRAP3	9967	broad.mit.edu	37	1	36754772	36754772	+	Silent	SNP	T	T	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:36754772T>G	uc001cae.3	+	5	1376	c.1152T>G	c.(1150-1152)GGT>GGG	p.G384G	THRAP3_uc001caf.3_Silent_p.G384G|THRAP3_uc001cag.1_Silent_p.G384G	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	384					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CAGGCTTGGGTGATGGAAAAA	0.403	Pancreas(129;785 1795 20938 23278 32581)		NA	T	USP6	aneurysmal bone cysts								6	81					0	0	0.004007	0	0
ZMPSTE24	10269	broad.mit.edu	37	1	40758302	40758302	+	Silent	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:40758302A>G	uc001cfg.2	+	10	1600	c.1389A>G	c.(1387-1389)CTA>CTG	p.L463L		NM_005857	NP_005848	O75844	FACE1_HUMAN	zinc metallopeptidase STE24	463						endoplasmic reticulum membrane|Golgi membrane|integral to membrane	metal ion binding|metalloexopeptidase activity				0	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			CTCCACTGCTAGAGAGACTTC	0.393			NA											3	101					0	0	0.004672	0	0
SLFNL1	200172	broad.mit.edu	37	1	41486213	41486213	+	Silent	SNP	G	G	C	rs146820397	byFrequency	TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:41486213G>C	uc001cgm.1	-	2	340	c.120C>G	c.(118-120)CTC>CTG	p.L40L	SLFNL1_uc009vwf.1_Silent_p.L40L|SLFNL1_uc001cgn.1_Silent_p.L40L|SLFNL1_uc009vwg.1_Silent_p.L40L	NM_144990	NP_659427	Q499Z3	SLNL1_HUMAN	schlafen-like 1	40							ATP binding			skin(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				GAGCCTCCTCGAGGTCAGAGT	0.637			NA											12	71					0	0	0.000978	0	0
CCDC30	728621	broad.mit.edu	37	1	43119529	43119529	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:43119529C>T	uc009vwk.1	+	16	2292	c.2182C>T	c.(2182-2184)CAA>TAA	p.Q728*	CCDC30_uc001chm.2_Nonsense_Mutation_p.Q426*|CCDC30_uc001chn.2_Nonsense_Mutation_p.Q517*	NM_001080850	NP_001074319	Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	728											0						TGCAAGTCTTCAAGAGACTGA	0.418			NA											5	62					0	0	0.001168	0	0
CCDC30	728621	broad.mit.edu	37	1	43119551	43119551	+	Nonsense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:43119551C>G	uc009vwk.1	+	16	2314	c.2204C>G	c.(2203-2205)TCA>TGA	p.S735*	CCDC30_uc001chm.2_Nonsense_Mutation_p.S433*|CCDC30_uc001chn.2_Nonsense_Mutation_p.S524*	NM_001080850	NP_001074319	Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	735											0						GAGATCAAGTCAAAAGAAGCA	0.398			NA											6	61					0	0	0.00308	0	0
LEPRE1	64175	broad.mit.edu	37	1	43215927	43215927	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:43215927C>T	uc001chv.2	-	11	1763	c.1650G>A	c.(1648-1650)GAG>GAA	p.E550E	LEPRE1_uc001chw.2_Silent_p.E550E|LEPRE1_uc001chx.3_Silent_p.E550E	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1	550					negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	GGAAGTAGGACTCCATGATGC	0.587			NA											4	12					0	0	0.009096	0	0
INADL	10207	broad.mit.edu	37	1	62237296	62237296	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:62237296A>G	uc001dab.2	+	6	832	c.718A>G	c.(718-720)ACA>GCA	p.T240A	INADL_uc009waf.1_Missense_Mutation_p.T240A|INADL_uc001daa.2_Missense_Mutation_p.T240A|INADL_uc001dad.3_5'UTR	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	240					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						TCTGCCTGAAACAGTGAGTTG	0.358			NA											3	30					0	0	0.004672	0	0
DNAJC6	9829	broad.mit.edu	37	1	65864515	65864515	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:65864515G>A	uc001dcd.1	+	14	2051	c.1887G>A	c.(1885-1887)GTG>GTA	p.V629V	DNAJC6_uc010opc.1_Silent_p.V616V|DNAJC6_uc001dce.1_Silent_p.V686V	NM_014787	NP_055602	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	629	Pro-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3						CGCCTGCTGTGAACATTCAGC	0.403			NA											5	66					0	0	0.001168	0	0
SGIP1	84251	broad.mit.edu	37	1	67147924	67147924	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:67147924C>A	uc001dcr.2	+	15	1404	c.1187C>A	c.(1186-1188)ACA>AAA	p.T396K	SGIP1_uc010opd.1_Intron|SGIP1_uc001dcs.2_Intron|SGIP1_uc001dct.2_Intron|SGIP1_uc009wat.2_Missense_Mutation_p.T163K	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	396	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						TACTTAGAAACAATCTCATCT	0.507			NA											18	130					1.33834e-09	1.97148e-09	0.007413	1	0
LRRC40	55631	broad.mit.edu	37	1	70654875	70654875	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:70654875C>A	uc001der.1	-	2	285	c.233G>T	c.(232-234)TGG>TTG	p.W78L		NM_017768	NP_060238	Q9H9A6	LRC40_HUMAN	leucine rich repeat containing 40	78										ovary(1)	1						CTGCTCCCACCATCTTTCAGT	0.433			NA											6	95					5.18039e-06	6.79926e-06	0.00308	1	0
ZZZ3	26009	broad.mit.edu	37	1	78098439	78098439	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:78098439C>A	uc001dhq.2	-	5	1077	c.601G>T	c.(601-603)GCT>TCT	p.A201S	ZZZ3_uc001dhr.2_Intron|ZZZ3_uc009wbz.1_Missense_Mutation_p.A201S|ZZZ3_uc001dhp.2_Missense_Mutation_p.A201S	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	201					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						CCATTGACAGCCAAATAGCCT	0.393			NA											23	112					3.83957e-06	5.06891e-06	0.00278	1	0
CLCA2	9635	broad.mit.edu	37	1	86890087	86890087	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:86890087G>C	uc001dlr.3	+	1	319	c.157G>C	c.(157-159)GAG>CAG	p.E53Q		NM_006536	NP_006527	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2 precursor	53	Extracellular (Potential).				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		TCAGGTACCTGAGAATCAGAA	0.408	Melanoma(157;1000 1898 5363 5664 48018)|Ovarian(88;135 1366 2838 28875 34642)		NA											3	58					0	0	0.004672	0	0
CLCA4	22802	broad.mit.edu	37	1	87040315	87040315	+	Silent	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:87040315C>G	uc009wcs.2	+	10	1604	c.1560C>G	c.(1558-1560)CTC>CTG	p.L520L	CLCA4_uc009wct.2_Silent_p.L283L|CLCA4_uc009wcu.2_Silent_p.L340L	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	520						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		CGTTCTTTCTCATCACATGGA	0.418			NA											17	78					0	0	0.006122	0	0
BARHL2	343472	broad.mit.edu	37	1	91182622	91182622	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:91182622C>G	uc001dns.2	-	1	173	c.131G>C	c.(130-132)AGG>ACG	p.R44T		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	44						nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		GGCCTGACTCCTAAAATCCGC	0.577	GBM(199;3561 4100 22440)		NA											6	101					0	0	0.001168	0	0
HFM1	164045	broad.mit.edu	37	1	91742270	91742270	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:91742270A>G	uc001doa.3	-	32	3603	c.3503T>C	c.(3502-3504)ATT>ACT	p.I1168T	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.I847T|HFM1_uc001dob.3_Missense_Mutation_p.I356T|HFM1_uc010osv.1_Missense_Mutation_p.I852T	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1168							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TGACTCTTTAATTTCTGACTT	0.294			NA											3	12					0	0	0.009096	0	0
ABCD3	5825	broad.mit.edu	37	1	94982646	94982646	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:94982646C>G	uc001dqn.3	+	23	2043	c.1941C>G	c.(1939-1941)TTC>TTG	p.F647L	ABCD3_uc010oto.1_Missense_Mutation_p.F671L|ABCD3_uc010otp.1_Missense_Mutation_p.F574L|ABCD3_uc009wdr.2_Missense_Mutation_p.F537L|ABCD3_uc001dqo.3_Missense_Mutation_p.F335L	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	647	ABC transporter.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		ACTATGAATTCAAACAGATAA	0.358			NA											21	73					0	0	0.001882	0	0
AGL	178	broad.mit.edu	37	1	100345510	100345510	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:100345510C>T	uc001dsi.1	+	13	2043	c.1643C>T	c.(1642-1644)CCC>CTC	p.P548L	AGL_uc001dsj.1_Missense_Mutation_p.P548L|AGL_uc001dsk.1_Missense_Mutation_p.P548L|AGL_uc001dsl.1_Missense_Mutation_p.P548L|AGL_uc001dsm.1_Missense_Mutation_p.P532L|AGL_uc001dsn.1_Missense_Mutation_p.P531L	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	548	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		AATTTGCAACCCAATTTATAT	0.373			NA											3	88					0	0	0.009096	0	0
RTCD1	8634	broad.mit.edu	37	1	100732078	100732078	+	Splice_Site	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:100732078A>T	uc001dtc.2	+	2	264	c.46_splice	c.e2-2	p.G16_splice	RTCD1_uc010ouh.1_Splice_Site_p.G16_splice|RTCD1_uc001dtd.2_Splice_Site_p.G16_splice	NM_003729	NP_003720	O00442	RTC1_HUMAN	RNA terminal phosphate cyclase domain 1 isoform						RNA processing	mitochondrion|nucleoplasm	ATP binding|protein binding|RNA binding|RNA-3'-phosphate cyclase activity				0		all_epithelial(167;0.000686)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0513)|all cancers(265;0.0902)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)		CAACCTTTGCAGGGCGGCCAG	0.632			NA											6	36					0	0	0.001168	0	0
S1PR1	1901	broad.mit.edu	37	1	101704852	101704852	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:101704852G>T	uc001dud.2	+	2	826	c.312G>T	c.(310-312)TTG>TTT	p.L104F	S1PR1_uc009weg.2_Missense_Mutation_p.L104F	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	104	Helical; Name=2; (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						ACCTGCTCTTGTCTGGGGCCA	0.547			NA									OREG0013620	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	43					0.00198382	0.00221159	0.001984	1	0
VAV3	10451	broad.mit.edu	37	1	108185330	108185330	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:108185330G>T	uc001dvk.1	-	20	1879	c.1825C>A	c.(1825-1827)CCA>ACA	p.P609T	VAV3_uc010ouu.1_Missense_Mutation_p.P13T|VAV3_uc001dvj.1_Missense_Mutation_p.P49T|VAV3_uc010ouv.1_Missense_Mutation_p.P13T|VAV3_uc010ouw.1_Missense_Mutation_p.P609T	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	609	SH3 1.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		TGCAGAGCTGGGGGTGGTGTT	0.443			NA											12	97					1.5842e-08	2.24927e-08	0.001855	1	0
VAV3	10451	broad.mit.edu	37	1	108185332	108185332	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:108185332G>C	uc001dvk.1	-	20	1877	c.1823C>G	c.(1822-1824)CCC>CGC	p.P608R	VAV3_uc010ouu.1_Missense_Mutation_p.P12R|VAV3_uc001dvj.1_Missense_Mutation_p.P48R|VAV3_uc010ouv.1_Missense_Mutation_p.P12R|VAV3_uc010ouw.1_Missense_Mutation_p.P608R	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	608	SH3 1.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		CAGAGCTGGGGGTGGTGTTCC	0.448			NA											10	94					0	0	0.001368	0	0
GSTM2	2946	broad.mit.edu	37	1	110214125	110214125	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:110214125G>A	uc001dyi.2	+	7	801	c.487G>A	c.(487-489)GTC>ATC	p.V163I	GSTM2_uc001dyj.2_Missense_Mutation_p.V163I|GSTM2_uc010ovt.1_Missense_Mutation_p.V163I|GSTM2_uc009wfk.2_RNA	NM_000848	NP_000839	P28161	GSTM2_HUMAN	glutathione S-transferase mu 2 isoform 1	163	GST C-terminal.				glutathione metabolic process|xenobiotic catabolic process	cytoplasm	glutathione transferase activity				0		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0122)|Colorectal(144;0.0129)|Epithelial(280;0.0146)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.047)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)	CGCTTATGATGTCCTTGAGAG	0.478			NA											13	86					0	0	0.007413	0	0
GSTM5	2949	broad.mit.edu	37	1	110256121	110256121	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:110256121G>T	uc001dyn.2	+	4	264	c.193G>T	c.(193-195)GAT>TAT	p.D65Y	GSTM5_uc010ovu.1_Missense_Mutation_p.D24Y	NM_000851	NP_000842	P46439	GSTM5_HUMAN	glutathione S-transferase mu 5	65	GST N-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity			central_nervous_system(6)	6		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Colorectal(144;0.0131)|all cancers(265;0.0252)|Epithelial(280;0.0265)|Lung(183;0.0425)|COAD - Colon adenocarcinoma(174;0.0474)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	CTACTTGATTGATGGGGCTCA	0.587			NA											24	140					2.44723e-14	3.91124e-14	0.004656	1	0
MAGI3	260425	broad.mit.edu	37	1	114189153	114189153	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:114189153G>A	uc001edk.2	+	12	2225	c.2044G>A	c.(2044-2046)GAG>AAG	p.E682K	MAGI3_uc001edh.3_Missense_Mutation_p.E707K|MAGI3_uc001edi.3_Missense_Mutation_p.E682K|MAGI3_uc010owm.1_Missense_Mutation_p.E707K|MAGI3_uc001edj.2_Missense_Mutation_p.E403K	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	707					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGCCATAAATGAGCCTATTCC	0.378			NA											4	75					0	0	0.009096	0	0
CD58	965	broad.mit.edu	37	1	117078851	117078851	+	Splice_Site	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:117078851C>G	uc001egm.2	-	3	486	c.365_splice	c.e3-1	p.E122_splice	CD58_uc001egn.2_Splice_Site|CD58_uc010owy.1_Splice_Site_p.E122_splice|CD58_uc001ego.1_Intron|CD58_uc001egp.3_Splice_Site_p.E122_splice	NM_001779	NP_001770	P19256	LFA3_HUMAN	CD58 molecule isoform 1						blood coagulation|cell-cell adhesion|leukocyte migration	anchored to membrane|integral to plasma membrane	protein binding				0	Lung SC(450;0.225)	all_cancers(81;0.000363)|all_lung(203;0.000118)|all_epithelial(167;0.000149)|Lung NSC(69;0.000577)		Lung(183;0.0086)|LUSC - Lung squamous cell carcinoma(189;0.0528)|Colorectal(144;0.0775)|all cancers(265;0.109)|Epithelial(280;0.118)|COAD - Colon adenocarcinoma(174;0.121)		GGAAGAGACTCTGGAAAAAAA	0.363			NA											7	18					0	0	0.00308	0	0
WDR3	10885	broad.mit.edu	37	1	118501533	118501533	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:118501533G>T	uc010oxe.1	+	26	2649	c.2583G>T	c.(2581-2583)AGG>AGT	p.R861S	WDR3_uc001ehi.2_Intron|SPAG17_uc001ehk.2_Intron	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	861						nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		TTTCTATCAGGATTCACTTTG	0.388			NA											8	49					1.12685e-05	1.45156e-05	0.004482	1	0
TCHH	7062	broad.mit.edu	37	1	152082950	152082950	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:152082950T>C	uc001ezp.2	-	2	2743	c.2743A>G	c.(2743-2745)AGA>GGA	p.R915G	TCHH_uc009wne.1_Missense_Mutation_p.R915G	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	915	4-1.|10 X 30 AA tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGCTCCTCTCTCTGTAGCTCC	0.597			NA											28	159					0	0	0.009535	0	0
FLG	2312	broad.mit.edu	37	1	152284173	152284173	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:152284173G>T	uc001ezu.1	-	3	3225	c.3189C>A	c.(3187-3189)CAC>CAA	p.H1063Q	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1063	Filaggrin 6.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGACCCCCAGTGTCCACTGT	0.577			NA							Ichthyosis				50	449					7.77372e-23	1.31209e-22	0.00361	1	0
LCE1F	353137	broad.mit.edu	37	1	152748972	152748972	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:152748972C>T	uc010pdv.1	+	1	125	c.125C>T	c.(124-126)TCC>TTC	p.S42F		NM_178354	NP_848131	Q5T754	LCE1F_HUMAN	late cornified envelope 1F	42					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ccTGTCTCTTCCTGCTGCAGC	0.413			NA											4	55					0	0	0.000602	0	0
PGLYRP3	114771	broad.mit.edu	37	1	153270489	153270489	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:153270489C>T	uc001fbn.1	-	7	1022	c.969G>A	c.(967-969)CTG>CTA	p.L323L		NM_052891	NP_443123	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3 precursor	323					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCCCAGGGGACAGGATGTTGA	0.597			NA											42	211					0	0	0.00361	0	0
AQP10	89872	broad.mit.edu	37	1	154295719	154295719	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:154295719G>T	uc001feu.2	+	4	413	c.373G>T	c.(373-375)GCC>TCC	p.A125S	AQP10_uc001fev.2_Missense_Mutation_p.A125S|ATP8B2_uc001few.2_5'Flank	NM_080429	NP_536354	Q96PS8	AQP10_HUMAN	aquaporin 10	125	Extracellular (Potential).				response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)	1	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTCCACAGATGCCCTACAGAA	0.542			NA											8	60					5.18039e-06	6.79926e-06	0.00308	1	0
C1orf66	51093	broad.mit.edu	37	1	156704034	156704034	+	Silent	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:156704034G>C	uc001fpu.2	+	6	1504	c.870G>C	c.(868-870)CTG>CTC	p.L290L	C1orf66_uc001fpv.2_Intron	NM_015997	NP_057081	Q96FB5	RRNAD_HUMAN	hypothetical protein LOC51093 isoform 1	290						integral to membrane	rRNA (adenine-N6,N6-)-dimethyltransferase activity				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ACATGAAGCTGAGTGACCCTG	0.642			NA											4	34					0	0	0.000602	0	0
HDGF	3068	broad.mit.edu	37	1	156713537	156713537	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:156713537C>T	uc001fpy.3	-	5	945	c.623G>A	c.(622-624)CGG>CAG	p.R208Q	MRPL24_uc001fpw.1_5'Flank|MRPL24_uc001fpx.1_5'Flank|HDGF_uc009wsd.2_Missense_Mutation_p.R176Q|HDGF_uc001fpz.3_Missense_Mutation_p.R201Q|HDGF_uc009wse.2_Missense_Mutation_p.R224Q|HDGF_uc010phr.1_Missense_Mutation_p.R231Q|HDGF_uc009wsf.2_Missense_Mutation_p.R176Q|HDGF_uc009wsg.2_Intron	NM_004494	NP_004485	P51858	HDGF_HUMAN	hepatoma-derived growth factor isoform a	208	Glu-rich.				cell proliferation|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	DNA binding|growth factor activity|heparin binding|nucleotide binding			lung(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)	Breast(1374;0.198)		Colorectal(1306;0.018)		GGGAGGCCCCCGGCCAGAGCC	0.502			NA											6	16					0	0	0.001168	0	0
SH2D2A	9047	broad.mit.edu	37	1	156779494	156779494	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:156779494C>A	uc001fqd.2	-	6	813	c.673G>T	c.(673-675)GCC>TCC	p.A225S	SH2D2A_uc001fqc.1_Missense_Mutation_p.A197S|SH2D2A_uc009wsh.2_Missense_Mutation_p.A235S|SH2D2A_uc001fqe.2_Missense_Mutation_p.A207S|SH2D2A_uc010phs.1_Missense_Mutation_p.A225S	NM_003975	NP_003966	Q9NP31	SH22A_HUMAN	SH2 domain protein 2A isoform 2	225	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity				0	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GGGACTGGGGCTTGCCCCTGT	0.607			NA											12	162					0.00136819	0.00153476	0.001368	1	0
OR10X1	128367	broad.mit.edu	37	1	158548836	158548836	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:158548836G>T	uc010pin.1	-	1	854	c.854C>A	c.(853-855)ACA>AAA	p.T285K		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	285	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TGCTATGAGTGTGTCATCTCC	0.448			NA											14	105					0.000151284	0.000180462	0.001855	1	0
OR6N1	128372	broad.mit.edu	37	1	158735635	158735635	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:158735635C>A	uc010piq.1	-	1	838	c.838G>T	c.(838-840)GTG>TTG	p.V280L		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GGTGTGAGCACTGAGTAGACC	0.507			NA											9	153					0.000274275	0.000318342	0.004482	1	0
CADM3	57863	broad.mit.edu	37	1	159169596	159169596	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:159169596C>T	uc001ftl.2	+	8	1150	c.1008C>T	c.(1006-1008)ATC>ATT	p.I336I	CADM3_uc001ftk.2_Silent_p.I370I|uc001ftm.1_RNA	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	336	Helical; (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					TCGGTGGGATCGTGGCTTTCA	0.557			NA											5	43					0	0	0.000602	0	0
NDUFS2	4720	broad.mit.edu	37	1	161180475	161180475	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:161180475G>T	uc001fyv.2	+	10	1409	c.961G>T	c.(961-963)GGT>TGT	p.G321C	NDUFS2_uc010pki.1_Missense_Mutation_p.G223C|NDUFS2_uc001fyw.2_Missense_Mutation_p.G321C|NDUFS2_uc010pkj.1_Missense_Mutation_p.G270C|NDUFS2_uc001fyx.2_Missense_Mutation_p.G295C	NM_004550	NP_004541	O75306	NDUS2_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 2	321					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding			skin(1)	1	all_cancers(52;1.16e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		NADH(DB00157)	TGTTCCTGTTGGTTCTCGAGG	0.527			NA											7	38					8.12818e-05	9.7994e-05	0.001984	1	0
ATF6	22926	broad.mit.edu	37	1	161771911	161771911	+	Missense_Mutation	SNP	A	A	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:161771911A>C	uc001gbr.2	+	7	825	c.758A>C	c.(757-759)CAG>CCG	p.Q253P	ATF6_uc001gbq.1_Missense_Mutation_p.Q253P	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	253	Cytoplasmic (Potential).				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			CCCTCTGCTCAGCCAGTCCTT	0.512			NA											11	84					0	0	0.008291	0	0
ASTN1	460	broad.mit.edu	37	1	177001649	177001649	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:177001649G>T	uc001glc.2	-	3	1020	c.808C>A	c.(808-810)CGC>AGC	p.R270S	ASTN1_uc001glb.1_Missense_Mutation_p.R270S|ASTN1_uc001gld.1_Missense_Mutation_p.R270S|ASTN1_uc009wwx.1_Missense_Mutation_p.R270S|ASTN1_uc001gle.3_RNA	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	270					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TCGAGGGTGCGCGTGACCTGG	0.582			NA											6	75					1.6384e-10	2.46169e-10	0.001984	1	0
FAM5B	57795	broad.mit.edu	37	1	177249713	177249713	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:177249713C>T	uc001glf.2	+	8	1713	c.1401C>T	c.(1399-1401)GCC>GCT	p.A467A	FAM5B_uc001glg.2_Silent_p.A362A	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	467						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CCGCGTGTGCCCACTGTGCTC	0.647			NA											3	26					0	0	0.004672	0	0
CACNA1E	777	broad.mit.edu	37	1	181726077	181726077	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:181726077G>T	uc001gow.2	+	30	4309	c.4144G>T	c.(4144-4146)GTA>TTA	p.V1382L	CACNA1E_uc009wxs.2_Missense_Mutation_p.V1270L|CACNA1E_uc001gox.1_Missense_Mutation_p.V608L|CACNA1E_uc009wxt.2_Missense_Mutation_p.V608L	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1382	Extracellular (Potential).|III.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GCAGCACTCTGTAGATGTGAC	0.463			NA											11	91					2.80697e-09	4.09483e-09	0.000978	1	0
C1orf26	54823	broad.mit.edu	37	1	185153463	185153463	+	Silent	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:185153463A>G	uc001grg.3	+	8	1341	c.1227A>G	c.(1225-1227)ACA>ACG	p.T409T	C1orf26_uc001grh.3_Silent_p.T409T	NM_001105518	NP_001098988	Q5T5J6	SWT1_HUMAN	hypothetical protein LOC54823	409	PINc.										0						TTTTGAAGACAACAGAAGTAC	0.279			NA											4	32					0	0	0.000602	0	0
HMCN1	83872	broad.mit.edu	37	1	186034450	186034450	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:186034450G>T	uc001grq.1	+	49	7823	c.7594G>T	c.(7594-7596)GGC>TGC	p.G2532C		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2532	Ig-like C2-type 23.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TATATCTGGTGGCCGTTTTCT	0.468			NA											8	24					0.00307968	0.00339969	0.00308	1	0
HMCN1	83872	broad.mit.edu	37	1	186141245	186141245	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:186141245G>T	uc001grq.1	+	102	16025	c.15796G>T	c.(15796-15798)GAA>TAA	p.E5266*	HMCN1_uc001grs.1_Nonsense_Mutation_p.E835*	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	5266	EGF-like 4; calcium-binding (Potential).				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GACCAAGGCAGAAAATGGAAC	0.428			NA											6	94					0.00198382	0.00221159	0.001984	1	0
FAM5C	339479	broad.mit.edu	37	1	190067370	190067370	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:190067370C>A	uc001gse.1	-	8	2311	c.2079G>T	c.(2077-2079)CAG>CAT	p.Q693H	FAM5C_uc010pot.1_Missense_Mutation_p.Q591H	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	693						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					CCTGGGATCCCTGAGTATAGG	0.448			NA											8	67					0.00307968	0.00339969	0.00308	1	0
FAM5C	339479	broad.mit.edu	37	1	190195291	190195291	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:190195291C>A	uc001gse.1	-	6	1114	c.882G>T	c.(880-882)ATG>ATT	p.M294I	FAM5C_uc010pot.1_Missense_Mutation_p.M192I	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	294						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					CTTGAATGTCCATGGAGGGGC	0.418			NA											5	34					8.12818e-05	9.7994e-05	0.001984	1	0
ASPM	259266	broad.mit.edu	37	1	197072203	197072203	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:197072203T>C	uc001gtu.2	-	18	6435	c.6178A>G	c.(6178-6180)AAA>GAA	p.K2060E	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2060	IQ 15.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TATTTCTTTTTGGTTTTGTAA	0.328			NA											10	127					0	0	0.000978	0	0
PTPRC	5788	broad.mit.edu	37	1	198668740	198668740	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:198668740C>T	uc001gur.1	+	5	520	c.340C>T	c.(340-342)CAG>TAG	p.Q114*	PTPRC_uc001gus.1_Nonsense_Mutation_p.Q114*|PTPRC_uc001gut.1_Intron|PTPRC_uc009wze.1_Nonsense_Mutation_p.Q50*|PTPRC_uc009wzf.1_Nonsense_Mutation_p.Q50*|PTPRC_uc010ppg.1_Nonsense_Mutation_p.Q50*|PTPRC_uc001guu.1_Nonsense_Mutation_p.Q157*|PTPRC_uc001guv.1_RNA|PTPRC_uc001guw.1_RNA	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	114	Extracellular (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						CGCAGACTCGCAGACGCCCTC	0.542			NA									OREG0014061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	81					0	0	0.004482	0	0
USH2A	7399	broad.mit.edu	37	1	215963401	215963401	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:215963401C>G	uc001hku.1	-	51	10569	c.10182G>C	c.(10180-10182)AAG>AAC	p.K3394N		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3394	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TATCAATTACCTTCATCATCA	0.338			NA								HNSCC(13;0.011)			8	38					0	0	0.00308	0	0
MOSC1	64757	broad.mit.edu	37	1	220970054	220970054	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:220970054G>T	uc001hms.2	+	3	767	c.519G>T	c.(517-519)CTG>CTT	p.L173L	MOSC1_uc001hmt.2_Silent_p.L173L	NM_022746	NP_073583	Q5VT66	MOSC1_HUMAN	MOCO sulphurase C-terminal domain containing 1	173							molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding				0				GBM - Glioblastoma multiforme(131;0.0358)		CCAGCTTCCTGAAGTCACAGC	0.602			NA											8	23					3.09899e-07	4.27887e-07	0.004482	1	0
ACBD3	64746	broad.mit.edu	37	1	226349305	226349305	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:226349305C>G	uc001hpy.2	-	4	702	c.655G>C	c.(655-657)GAG>CAG	p.E219Q		NM_022735	NP_073572	Q9H3P7	GCP60_HUMAN	acyl-Coenzyme A binding domain containing 3	219	Arg-rich.|Potential.|Glu-rich.				steroid biosynthetic process|transport	Golgi membrane|integral to membrane|mitochondrion	fatty-acyl-CoA binding|protein binding				0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.121)		agcctttcctcttcttctctc	0.109			NA											17	36					0	0	0.004007	0	0
TSNAX	7257	broad.mit.edu	37	1	231700291	231700291	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:231700291G>A	uc001huw.2	+	6	671	c.513G>A	c.(511-513)CAG>CAA	p.Q171Q	TSNAX-DISC1_uc010pwe.1_Intron|TSNAX-DISC1_uc010pwf.1_Intron|TSNAX-DISC1_uc010pwg.1_Intron|TSNAX-DISC1_uc010pwh.1_Intron|TSNAX-DISC1_uc010pwi.1_Intron|TSNAX-DISC1_uc010pwj.1_Intron|TSNAX-DISC1_uc010pwk.1_Intron|TSNAX-DISC1_uc010pwl.1_Intron	NM_005999	NP_005990	Q99598	TSNAX_HUMAN	translin-associated factor X	171	Interaction with C1D.				cell differentiation|multicellular organismal development|spermatogenesis	nucleus|perinuclear region of cytoplasm	protein transporter activity|sequence-specific DNA binding				0		all_cancers(173;0.0395)|Acute lymphoblastic leukemia(190;3.76e-06)|Prostate(94;0.116)				CTGATGCACAGGATAAGCAGT	0.413			NA											14	199					0	0	0.00245	0	0
TARBP1	6894	broad.mit.edu	37	1	234584263	234584263	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:234584263G>C	uc001hwd.2	-	11	1924	c.1924C>G	c.(1924-1926)CTG>GTG	p.L642V		NM_005646	NP_005637	Q13395	TARB1_HUMAN	TAR RNA binding protein 1	642					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			TCCACAGCCAGCAAGACCATC	0.368			NA											8	49					0	0	0.006214	0	0
ZP4	57829	broad.mit.edu	37	1	238053401	238053401	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:238053401G>C	uc001hym.2	-	2	251	c.251C>G	c.(250-252)TCC>TGC	p.S84C	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	84	Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			CAACACCACGGAGCTGCCTGG	0.567	NSCLC(166;160 2029 11600 18754 19936)		NA											13	87					0	0	0.001855	0	0
CHRM3	1131	broad.mit.edu	37	1	240072435	240072435	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:240072435C>A	uc001hyp.2	+	5	2463	c.1684C>A	c.(1684-1686)CAG>AAG	p.Q562K		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	562	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GCTGCTGTGCCAGTGTGACAA	0.517			NA											6	69					3.59834e-05	4.47562e-05	0.001168	1	0
CEP170	9859	broad.mit.edu	37	1	243327605	243327605	+	Silent	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:243327605T>C	uc001hzs.2	-	13	4065	c.3657A>G	c.(3655-3657)TCA>TCG	p.S1219S	CEP170_uc001hzt.2_Silent_p.S1121S|CEP170_uc001hzu.2_Silent_p.S1121S|CEP170_uc001hzv.1_Silent_p.S597S	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	1219	Targeting to microtubules.|Targeting to centrosomes.					centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			AGCCATGAGCTGAGGTCATAC	0.378			NA											3	53					0	0	0.009096	0	0
NLRP3	114548	broad.mit.edu	37	1	247588857	247588857	+	Silent	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:247588857G>C	uc001icr.2	+	5	2250	c.2112G>C	c.(2110-2112)GTG>GTC	p.V704V	NLRP3_uc001ics.2_Silent_p.V704V|NLRP3_uc001icu.2_Silent_p.V704V|NLRP3_uc001icw.2_Silent_p.V704V|NLRP3_uc001icv.2_Silent_p.V704V|NLRP3_uc010pyw.1_Silent_p.V702V|NLRP3_uc001ict.1_Silent_p.V702V	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	704					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TTGATATGGTGCAGTGTGTCC	0.547			NA											3	40					0	0	0.000602	0	0
OR2M2	391194	broad.mit.edu	37	1	248343636	248343636	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:248343636G>A	uc010pzf.1	+	1	349	c.349G>A	c.(349-351)GTT>ATT	p.V117I		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCTTTTGGCTGTTATGGCTTA	0.403			NA											41	293					0	0	0.00623	0	0
OR2T12	127064	broad.mit.edu	37	1	248458109	248458109	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:248458109T>A	uc010pzj.1	-	1	772	c.772A>T	c.(772-774)ATG>TTG	p.M258L		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	258	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			TTGGGTCTCATATAGGTAAAA	0.488			NA											9	103					0	0	0.004482	0	0
OR2T10	127069	broad.mit.edu	37	1	248756151	248756151	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr1:248756151C>A	uc010pzn.1	-	1	919	c.919G>T	c.(919-921)GTG>TTG	p.V307L		NM_001004693	NP_001004693	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T,	307	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGTTTCTGCACGCTCAGCATT	0.393			NA											10	99					3.86212e-05	4.77085e-05	0.008291	1	0
ITIH5	80760	broad.mit.edu	37	10	7657998	7657998	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr10:7657998C>A	uc001ijq.2	-	7	965	c.886G>T	c.(886-888)GTG>TTG	p.V296L	ITIH5_uc001ijp.2_Missense_Mutation_p.V82L|ITIH5_uc001ijr.1_Missense_Mutation_p.V296L	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	296	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						ACGAATACCACATTCTTGGGT	0.473			NA											4	84					0.00024832	0.000291212	0.009096	1	0
ITIH2	3698	broad.mit.edu	37	10	7785208	7785208	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr10:7785208C>G	uc001ijs.2	+	17	2357	c.2195C>G	c.(2194-2196)TCT>TGT	p.S732C		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	732					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						AACCTGGTTTCTGACCCAGAA	0.353			NA											11	167					0	0	0.001368	0	0
RBP3	5949	broad.mit.edu	37	10	48388080	48388080	+	Missense_Mutation	SNP	A	A	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr10:48388080A>C	uc001jez.2	-	1	2912	c.2798T>G	c.(2797-2799)CTG>CGG	p.L933R		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	933	4 X approximate tandem repeats.|4.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CTTGGCACGCAGAGCCACTAT	0.632			NA											7	37					0	0	0.006214	0	0
DRGX	644168	broad.mit.edu	37	10	50599243	50599243	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr10:50599243C>A	uc010qgq.1	-	2	114	c.114G>T	c.(112-114)CAG>CAT	p.Q38H		NM_001080520	NP_001073989	A6NNA5	DRGX_HUMAN	dorsal root ganglia homeobox	38					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGTTCCGGCGCTGTTTTCTAC	0.502			NA											4	12					0.000602214	0.000690978	0.000602	1	0
SLC18A3	6572	broad.mit.edu	37	10	50820238	50820238	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr10:50820238G>T	uc001jhw.2	+	1	1892	c.1452G>T	c.(1450-1452)GTG>GTT	p.V484V	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank|CHAT_uc010qgs.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	484	Cytoplasmic (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						AGCGCGATGTGCTGCTTGATG	0.667			NA											9	38					9.70103e-10	1.44555e-09	0.008291	1	0
PCDH15	65217	broad.mit.edu	37	10	55568824	55568825	+	Missense_Mutation	DNP	TG	TG	GT			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr10:55568824_55568825TG>GT	uc010qhs.1	-	37	5395_5396	c.5000_5001CA>AC	c.(4999-5001)GCA>GAC	p.A1667D	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qht.1_Missense_Mutation_p.A1660D|PCDH15_uc010qhu.1_3'UTR	NM_001142769	NP_001136241	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD2-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding	p.P1667H(1)		pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GCCTTCTTCTTGCAAGCACAAT	0.361			NA								HNSCC(58;0.16)			7	19					0	0	0.004672	0	0
BICC1	80114	broad.mit.edu	37	10	60549174	60549174	+	Silent	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr10:60549174T>A	uc001jki.1	+	7	753	c.753T>A	c.(751-753)ACT>ACA	p.T251T		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	251					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						ATGGTGCTACTGTCATAGTAC	0.373			NA											26	87					0	0	0.007291	0	0
CTNNA3	29119	broad.mit.edu	37	10	67726441	67726441	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr10:67726441G>A	uc009xpn.1	-	17	2452	c.2329C>T	c.(2329-2331)CAC>TAC	p.H777Y	CTNNA3_uc001jmw.2_Missense_Mutation_p.H777Y	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	777					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						TTCAGTTGGTGGGAGTAGAAC	0.423			NA											17	54					0	0	0.006122	0	0
USP54	159195	broad.mit.edu	37	10	75283501	75283501	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr10:75283501C>G	uc001juo.2	-	15	2219	c.2202G>C	c.(2200-2202)GAG>GAC	p.E734D	USP54_uc010qkk.1_5'UTR|USP54_uc001juk.2_5'UTR|USP54_uc001jul.2_5'UTR|USP54_uc001jum.2_RNA|USP54_uc001jun.2_RNA|USP54_uc001jup.2_Missense_Mutation_p.E734D	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	734					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					TAGAAGATATCTCCTCACCTG	0.438	Colon(195;880 2046 8854 25025 38456)		NA											50	158					0	0	0.00361	0	0
NOC3L	64318	broad.mit.edu	37	10	96099595	96099595	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr10:96099595C>T	uc001kjq.1	-	17	1951	c.1863G>A	c.(1861-1863)CAG>CAA	p.Q621Q		NM_022451	NP_071896	Q8WTT2	NOC3L_HUMAN	nucleolar complex associated 3 homolog	621						nuclear speck|nucleolus	binding			ovary(1)	1		Colorectal(252;0.0897)				CAAGAGCTCGCTGCTGAGAAA	0.418			NA											14	43					0	0	0.003163	0	0
RRP12	23223	broad.mit.edu	37	10	99126286	99126286	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr10:99126286T>C	uc001knf.2	-	28	3447	c.3308A>G	c.(3307-3309)CAG>CGG	p.Q1103R	RRP12_uc001kne.2_Missense_Mutation_p.Q118R|RRP12_uc009xvl.2_Missense_Mutation_p.Q220R|RRP12_uc009xvm.2_Missense_Mutation_p.Q821R|RRP12_uc010qou.1_Missense_Mutation_p.Q1042R|RRP12_uc009xvn.2_Missense_Mutation_p.Q1003R	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	1103						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		CCGGCTCCTCTGTCGTGCCAG	0.602			NA											28	88					0	0	0.007291	0	0
LZTS2	84445	broad.mit.edu	37	10	102763281	102763281	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr10:102763281G>A	uc001ksj.2	+	3	495	c.426G>A	c.(424-426)CTG>CTA	p.L142L	LZTS2_uc010qpw.1_Silent_p.L142L|LZTS2_uc001ksk.2_Silent_p.L142L|LZTS2_uc001ksl.2_Silent_p.L142L|LZTS2_uc001ksm.2_RNA	NM_032429	NP_115805	Q9BRK4	LZTS2_HUMAN	leucine zipper, putative tumor suppressor 2	142	Required for centrosomal localization (By similarity).				cell division|mitosis|Wnt receptor signaling pathway	membrane|microtubule|microtubule organizing center				ovary(2)|large_intestine(1)|breast(1)	4				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		AGAAGATCCTGATCCGCCCAA	0.602	Esophageal Squamous(8;38 437 13604 19902 37640)		NA											30	79					0	0	0.002096	0	0
CALHM1	255022	broad.mit.edu	37	10	105215108	105215108	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr10:105215108C>G	uc001kxe.2	-	2	1092	c.952G>C	c.(952-954)GAG>CAG	p.E318Q	CALHM2_uc001kxa.2_5'Flank|CALHM2_uc001kxc.2_5'Flank|CALHM2_uc001kxb.2_5'Flank|CALHM2_uc001kxd.1_5'Flank	NM_001001412	NP_001001412	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	318						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			ovary(1)	1						GGTGGCTCCTCCTGGCCCAGC	0.647			NA											4	26					0	0	0.009096	0	0
SORCS3	22986	broad.mit.edu	37	10	106917010	106917010	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr10:106917010G>T	uc001kyi.1	+	10	1824	c.1597G>T	c.(1597-1599)GAC>TAC	p.D533Y		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	533	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TCCGGATGTGGACCTGAGAGG	0.567	NSCLC(116;1497 1690 7108 13108 14106)		NA											14	37					9.31168e-06	1.21334e-05	0.001855	1	0
TACC2	10579	broad.mit.edu	37	10	123845089	123845089	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr10:123845089C>T	uc001lfv.2	+	4	3434	c.3074C>T	c.(3073-3075)TCC>TTC	p.S1025F	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.S1025F|TACC2_uc010qtv.1_Missense_Mutation_p.S1025F	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1025						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GATGGTTGTTCCCCACTCTGG	0.547			NA											7	24					0	0	0.00308	0	0
MKI67	4288	broad.mit.edu	37	10	129913972	129913972	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr10:129913972C>A	uc001lke.2	-	7	895	c.700G>T	c.(700-702)GAA>TAA	p.E234*	MKI67_uc001lkf.2_Intron|MKI67_uc009yav.1_Intron|MKI67_uc009yaw.1_Intron	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	234					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				AAGGGAGATTCATTTTTTTTG	0.343			NA											12	40					6.40141e-05	7.8539e-05	0.000978	1	0
CTSD	1509	broad.mit.edu	37	11	1774823	1774823	+	Missense_Mutation	SNP	C	C	A	rs121912790		TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:1774823C>A	uc001luc.1	-	9	1282	c.1149G>T	c.(1147-1149)TGG>TGT	p.W383C	CTSD_uc009yda.1_RNA	NM_001909	NP_001900	P07339	CATD_HUMAN	cathepsin D preproprotein	383			W -> C (in CLN10).		cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity				0		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CGCCCAGGATCCAGAGTGGCC	0.652			NA											11	59					0.000673444	0.000770748	0.008291	1	0
OR51F2	119694	broad.mit.edu	37	11	4843137	4843137	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:4843137G>T	uc010qyn.1	+	1	522	c.522G>T	c.(520-522)ATG>ATT	p.M174I		NM_001004753	NP_001004753	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F,	174	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCCAGTCATGCTCTTTGTCA	0.448			NA											25	203					6.36457e-07	8.68159e-07	0.003954	1	0
UBQLN3	50613	broad.mit.edu	37	11	5529338	5529338	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:5529338C>T	uc001may.1	-	2	1537	c.1451G>A	c.(1450-1452)AGA>AAA	p.R484K	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_5'Flank|OR51B5_uc001maq.1_5'Flank	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	484										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTCAGAGATCTTGGATAAGC	0.552	Ovarian(72;684 1260 12332 41642 52180)		NA											7	66					0	0	0.004482	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537461	5537461	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:5537461C>A	uc001maz.3	-	1	496	c.211G>T	c.(211-213)GTG>TTG	p.V71L	HBG2_uc001mak.1_Intron	NM_145053	NP_659490	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	71	Ubiquitin-like.									large_intestine(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		AAGACCAGCACTAGTTGGTCC	0.498			NA											9	70					0.000442599	0.00050913	0.006214	1	0
OR52N1	79473	broad.mit.edu	37	11	5809298	5809298	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:5809298A>G	uc010qzo.1	-	1	749	c.749T>C	c.(748-750)ATA>ACA	p.I250T	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001913	NP_001001913	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		GGTGAGGACTATGGCACAGAA	0.448			NA											10	78					0	0	0.008291	0	0
NLRP14	338323	broad.mit.edu	37	11	7070902	7070902	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:7070902G>T	uc001mfb.1	+	6	2447	c.2124G>T	c.(2122-2124)CTG>CTT	p.L708L		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	708					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TCTTCTGAAGGTTGAAATTTA	0.343			NA											7	107					0.00448238	0.00490617	0.004482	1	0
OLFML1	283298	broad.mit.edu	37	11	7530705	7530705	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:7530705G>A	uc001mfi.2	+	3	847	c.495G>A	c.(493-495)ATG>ATA	p.M165I	OLFML1_uc010raz.1_Missense_Mutation_p.M29I|OLFML1_uc010rba.1_Missense_Mutation_p.M165I	NM_198474	NP_940876	Q6UWY5	OLFL1_HUMAN	olfactomedin-like 1 precursor	165	Olfactomedin-like.					extracellular region				ovary(2)	2				Epithelial(150;6.96e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		GCTCTTGGATGAAAGATGCTG	0.413			NA											7	121					0	0	0.001984	0	0
MYOD1	4654	broad.mit.edu	37	11	17741348	17741348	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:17741348C>A	uc001mni.2	+	1	239	c.19C>A	c.(19-21)CCG>ACG	p.P7T		NM_002478	NP_002469	P15172	MYOD1_HUMAN	myogenic differentiation 1	7					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|skeletal muscle tissue development	nuclear chromatin|transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity			breast(2)|ovary(1)	3						ACTGTCGCCACCGCTCCGCGA	0.657			NA											7	49					1.12685e-05	1.45156e-05	0.004482	1	0
MRGPRX4	117196	broad.mit.edu	37	11	18194908	18194908	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:18194908C>A	uc001mnv.1	+	1	525	c.105C>A	c.(103-105)TGC>TGA	p.C35*		NM_054032	NP_473373	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	35	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						TGCTGACGTGCATCATTTCCC	0.552			NA											22	105					3.6726e-16	5.96468e-16	0.003954	1	0
LDHA	3939	broad.mit.edu	37	11	18424527	18424527	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:18424527G>T	uc001mok.3	+	5	831	c.559G>T	c.(559-561)GGG>TGG	p.G187W	LDHA_uc010rdc.1_Missense_Mutation_p.G129W|LDHA_uc009yhn.2_Missense_Mutation_p.G187W|LDHA_uc009yho.2_Missense_Mutation_p.G14W|LDHA_uc001mol.3_Missense_Mutation_p.G187W|LDHA_uc010rdd.1_Missense_Mutation_p.G216W	NM_005566	NP_005557	P00338	LDHA_HUMAN	lactate dehydrogenase A isoform 1	187					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity|protein binding			central_nervous_system(3)	3					NADH(DB00157)	AAGCTGTCATGGGTGGGTCCT	0.418			NA											8	57					7.48243e-07	1.00996e-06	0.006214	1	0
KCNA4	3739	broad.mit.edu	37	11	30032746	30032746	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:30032746T>A	uc001msk.2	-	2	2632	c.1480A>T	c.(1480-1482)AGT>TGT	p.S494C		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	494	Helical; Name=Segment S5; (Potential).					voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TACACAGCACTAGAAAAGAGG	0.527			NA											9	34					0	0	0.006214	0	0
CCDC73	493860	broad.mit.edu	37	11	32674742	32674742	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:32674742T>A	uc001mtv.2	-	12	910	c.866A>T	c.(865-867)CAG>CTG	p.Q289L	CCDC73_uc001mtw.1_Missense_Mutation_p.Q279L	NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	289	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					CCGAAGTAACTGCTGCATATG	0.274			NA											6	67					0	0	0.004482	0	0
HIPK3	10114	broad.mit.edu	37	11	33308507	33308507	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:33308507C>T	uc001mul.1	+	2	817	c.547C>T	c.(547-549)CAG>TAG	p.Q183*	HIPK3_uc001mum.1_Nonsense_Mutation_p.Q183*|HIPK3_uc009yjv.1_Nonsense_Mutation_p.Q183*	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	183					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						AGGTGACTATCAGTTAGTACA	0.428			NA											10	65					0	0	0.006214	0	0
PAMR1	25891	broad.mit.edu	37	11	35463205	35463205	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:35463205G>T	uc001mwg.2	-	7	900	c.857C>A	c.(856-858)CCA>CAA	p.P286Q	PAMR1_uc001mwf.2_Missense_Mutation_p.P303Q|PAMR1_uc010rew.1_Missense_Mutation_p.P175Q|PAMR1_uc010rex.1_Missense_Mutation_p.P246Q	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	286	Sushi 1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						CCCATTGACTGGGCCCCCAGG	0.418			NA											24	64					3.01185e-09	4.38661e-09	0.003954	1	0
SYT13	57586	broad.mit.edu	37	11	45274079	45274079	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:45274079C>G	uc001myq.2	-	4	865	c.739G>C	c.(739-741)GAC>CAC	p.D247H	SYT13_uc009yku.1_Missense_Mutation_p.D103H	NM_020826	NP_065877	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	247	Cytoplasmic (Potential).|C2 1.					transport vesicle				ovary(1)	1						GAGAAGCGGTCGCAGGTCCTC	0.697			NA									OREG0020928	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	47					0	0	0.00245	0	0
CHST1	8534	broad.mit.edu	37	11	45671248	45671248	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:45671248G>T	uc001mys.1	-	4	1897	c.1226C>A	c.(1225-1227)CCC>CAC	p.P409H		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	409	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		TCACGAGAAGGGGCGGAAGTC	0.627			NA											6	73					3.59834e-05	4.47562e-05	0.001168	1	0
CELF1	10658	broad.mit.edu	37	11	47493789	47493789	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:47493789G>A	uc001nfl.2	-	12	1464	c.1454C>T	c.(1453-1455)CCC>CTC	p.P485L	CELF1_uc001nfk.1_5'Flank|CELF1_uc001nfm.2_Missense_Mutation_p.P482L|CELF1_uc001nfn.2_Missense_Mutation_p.P481L|CELF1_uc001nfo.1_Missense_Mutation_p.P511L|CELF1_uc010rhm.1_Missense_Mutation_p.P484L|CELF1_uc001nfp.2_Missense_Mutation_p.P513L|CELF1_uc001nfq.1_Missense_Mutation_p.P485L|CELF1_uc001nfr.1_Missense_Mutation_p.P485L	NM_001025596	NP_001020767	Q92879	CELF1_HUMAN	CUG triplet repeat, RNA-binding protein 1	485					embryo development|mRNA splice site selection|regulation of RNA splicing|RNA interference	cytoplasm|nucleus|ribonucleoprotein complex	BRE binding|mRNA binding|nucleotide binding|translation repressor activity, nucleic acid binding			central_nervous_system(2)|ovary(1)	3						CGCTCAGTAGGGCTTGCTGTC	0.542	Pancreas(163;1949 1966 9906 43218 43785)		NA											38	194					0	0	0.00623	0	0
OR4P4	81300	broad.mit.edu	37	11	55405905	55405905	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:55405905C>T	uc010rij.1	+	1	72	c.72C>T	c.(70-72)CTC>CTT	p.L24L		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	24	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TTGAAGTCCTCTGCTTTGTAT	0.358			NA											27	46					0	0	0.003954	0	0
OR5D14	219436	broad.mit.edu	37	11	55563206	55563206	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:55563206A>T	uc010rim.1	+	1	175	c.175A>T	c.(175-177)ACT>TCT	p.T59S		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	59	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				CAAATTTCACACTCCTATGTA	0.383			NA											20	110					0	0	0.008871	0	0
OR5L2	26338	broad.mit.edu	37	11	55594977	55594977	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:55594977C>G	uc001nhy.1	+	1	283	c.283C>G	c.(283-285)CTA>GTA	p.L95V		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				CATCTCCTTCCTAGGGTGCAT	0.458			NA								HNSCC(27;0.073)			17	154					0	0	0.007413	0	0
SPRYD5	84767	broad.mit.edu	37	11	55653297	55653297	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:55653297G>T	uc010rip.1	+	2	485	c.393G>T	c.(391-393)TGG>TGT	p.W131C	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	131						intracellular	zinc ion binding				0		all_epithelial(135;0.226)				CCATTGAGTGGGCTGCTGAGG	0.468			NA											5	37					0.00116845	0.00131559	0.001168	1	0
OR5I1	10798	broad.mit.edu	37	11	55703124	55703124	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:55703124C>A	uc010ris.1	-	1	753	c.753G>T	c.(751-753)ACG>ACT	p.T251T		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTTGGTAGATCGTCACTGAAG	0.428			NA											5	25					1.23904e-05	1.57585e-05	0.000602	1	0
OR8I2	120586	broad.mit.edu	37	11	55860792	55860792	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:55860792C>A	uc010rix.1	+	1	9	c.9C>A	c.(7-9)GGC>GGA	p.G3G		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					AAATGGCTGGCAACAATTTCA	0.368			NA											9	106					0.000274275	0.000318342	0.004482	1	0
OR5M8	219484	broad.mit.edu	37	11	56258197	56258197	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:56258197T>C	uc001nix.1	-	1	650	c.650A>G	c.(649-651)TAC>TGC	p.Y217C		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	217	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					AATGTAAAGGTAGGAAATACA	0.408			NA											5	63					0	0	0.001168	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57076892	57076892	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:57076892C>T	uc001njr.2	-	5	3605	c.3293G>A	c.(3292-3294)CGA>CAA	p.R1098Q	TNKS1BP1_uc001njs.2_Missense_Mutation_p.R1098Q|TNKS1BP1_uc009ymd.1_Missense_Mutation_p.R549Q	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1098	Gly-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				TGCTGCCTCTCGCTGGGGGCC	0.612			NA											11	43					0	0	0.008291	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947084	57947084	+	Missense_Mutation	SNP	C	C	A	rs141876179	byFrequency	TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:57947084C>A	uc001nmj.2	+	3	484	c.168C>A	c.(166-168)CAC>CAA	p.H56Q		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	56	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				ACCAGCTCCACGCTCCAATGT	0.488			NA											17	149					6.49762e-13	1.02041e-12	0.006122	1	0
OR1S2	219958	broad.mit.edu	37	11	57970865	57970865	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:57970865C>A	uc010rkb.1	-	1	789	c.789G>T	c.(787-789)CTG>CTT	p.L263L		NM_001004459	NP_001004459	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S,	263	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				TTCCGTAGAACAGTAATGCAA	0.502			NA											15	45					2.31682e-05	2.90165e-05	0.003163	1	0
MS4A1	931	broad.mit.edu	37	11	60235735	60235735	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:60235735C>G	uc001npp.2	+	8	1104	c.688C>G	c.(688-690)CTG>GTG	p.L230V	MS4A1_uc001npq.2_Missense_Mutation_p.L230V|MS4A1_uc009yna.2_Missense_Mutation_p.L230V|MS4A1_uc009ymz.2_Missense_Mutation_p.L217V|MS4A1_uc010rlc.1_Missense_Mutation_p.L63V	NM_152866	NP_690605	P11836	CD20_HUMAN	membrane-spanning 4-domains, subfamily A, member	230	Cytoplasmic (Potential).				B cell activation|immune response	integral to plasma membrane				ovary(3)|lung(2)	5					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)	CATAGTTCTCCTGTCAGCAGA	0.338			NA											6	20					0	0	0.001168	0	0
SCGB1A1	7356	broad.mit.edu	37	11	62186609	62186609	+	Silent	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:62186609C>G	uc001ntj.2	+	1	87	c.42C>G	c.(40-42)CTC>CTG	p.L14L		NM_003357	NP_003348	P11684	UTER_HUMAN	secretoglobin, family 1A, member 1	14					embryo implantation|signal transduction	extracellular region	binding|phospholipase A2 inhibitor activity				0						CACTGGCTCTCTGCTGCAGCT	0.607			NA											5	20					0	0	0.000602	0	0
RTN3	10313	broad.mit.edu	37	11	63487182	63487182	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:63487182G>T	uc001nxq.2	+	3	1395	c.1208G>T	c.(1207-1209)GGT>GTT	p.G403V	RTN3_uc001nxo.2_Intron|RTN3_uc001nxm.2_Intron|RTN3_uc001nxn.2_Missense_Mutation_p.G384V|RTN3_uc001nxp.2_Intron|RTN3_uc009yov.2_Missense_Mutation_p.G291V|RTN3_uc010rmt.1_Intron|RTN3_uc010rmu.1_Intron	NM_201428	NP_958831	O95197	RTN3_HUMAN	reticulon 3 isoform b	403					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				ovary(1)	1						AAATCAACAGGTGATTGGGCA	0.378			NA											8	56					5.4927e-09	7.93586e-09	0.004482	1	0
NAALADL1	10004	broad.mit.edu	37	11	64821818	64821818	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:64821818T>A	uc001ocn.2	-	6	912	c.896A>T	c.(895-897)AAC>ATC	p.N299I	NAALADL1_uc010rnw.1_5'UTR	NM_005468	NP_005459	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic	299	NAALADase.|Extracellular (Potential).				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity				0						CAAAGTTCCGTTGAGGTTACT	0.637			NA											5	49					0	0	0.000602	0	0
TSGA10IP	254187	broad.mit.edu	37	11	65721100	65721100	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:65721100G>T	uc001ogk.1	+	7	1246	c.1214G>T	c.(1213-1215)CGG>CTG	p.R405L	TSGA10IP_uc009yqw.1_RNA|TSGA10IP_uc009yqx.1_RNA	NM_152762	NP_689975	Q3SY00	T10IP_HUMAN	testis specific, 10 interacting protein	405	Potential.										0						GAGCTGCGGCGGGCCCGGACA	0.716			NA											11	45					5.16669e-11	7.84121e-11	0.000978	1	0
CTSF	8722	broad.mit.edu	37	11	66333336	66333336	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:66333336G>A	uc001oip.2	-	7	1020	c.930C>T	c.(928-930)CTC>CTT	p.L310L		NM_003793	NP_003784	Q9UBX1	CATF_HUMAN	cathepsin F precursor	310					proteolysis	lysosome	cysteine-type endopeptidase activity				0						TCCCCTGGTTGAGAAACCACT	0.617			NA											7	44					0	0	0.00308	0	0
TPCN2	219931	broad.mit.edu	37	11	68846407	68846407	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:68846407C>T	uc001oos.2	+	16	1574	c.1458C>T	c.(1456-1458)CTC>CTT	p.L486L	TPCN2_uc001oor.2_Silent_p.L401L|TPCN2_uc010rqg.1_Silent_p.L486L|TPCN2_uc001oot.2_RNA	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	486	Helical; Name=S2 of repeat II; (Potential).				cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			AGATGCTGCTCAAGGTCTTTG	0.582			NA											12	64					0	0	0.00245	0	0
KRTAP5-9	3846	broad.mit.edu	37	11	71259944	71259944	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:71259944A>T	uc001oqs.1	+	1	479	c.241A>T	c.(241-243)AGT>TGT	p.S81C		NM_005553	NP_005544	P26371	KRA59_HUMAN	keratin associated protein 5-9	81	8 X 4 AA repeats of C-C-X-P.				epidermis development	keratin filament					0						CTCCCAGTGCAGTTGCTGCAA	0.622			NA											17	127					0	0	0.007413	0	0
UVRAG	7405	broad.mit.edu	37	11	75727892	75727892	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:75727892G>T	uc001oxc.2	+	12	1335	c.1094G>T	c.(1093-1095)GGT>GTT	p.G365V	UVRAG_uc010rrw.1_Missense_Mutation_p.G264V|UVRAG_uc001oxd.2_5'UTR|UVRAG_uc010rrx.1_5'UTR|UVRAG_uc009yuh.1_RNA	NM_003369	NP_003360	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	365					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			skin(4)|lung(2)	6						GTTGCCCTTGGTTATACTGCA	0.343			NA											11	111					7.93312e-07	1.0676e-06	0.00245	1	0
UVRAG	7405	broad.mit.edu	37	11	75852456	75852456	+	Nonstop_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:75852456G>T	uc001oxc.2	+	15	2340	c.2099G>T	c.(2098-2100)TGA>TTA	p.*700L	UVRAG_uc010rrw.1_Nonstop_Mutation_p.*599L|UVRAG_uc001oxd.2_Nonstop_Mutation_p.*328L|UVRAG_uc010rrx.1_Nonstop_Mutation_p.*328L|UVRAG_uc010rry.1_Nonstop_Mutation_p.*256L	NM_003369	NP_003360	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	700					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			skin(4)|lung(2)	6						TCCGATAAGTGAAGTGAGCAG	0.463			NA											4	34					1.23904e-05	1.57585e-05	0.000602	1	0
NAALAD2	10003	broad.mit.edu	37	11	89896521	89896521	+	Silent	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:89896521T>C	uc001pdf.3	+	10	1228	c.1119T>C	c.(1117-1119)TTT>TTC	p.F373F	NAALAD2_uc009yvx.2_Silent_p.F340F|NAALAD2_uc009yvy.2_Intron|NAALAD2_uc001pde.2_Silent_p.F280F	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	373	Extracellular (Potential).|NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				CCTGGGTATTTGGAGCTATTG	0.393			NA											33	131					0	0	0.002445	0	0
FAT3	120114	broad.mit.edu	37	11	92616425	92616425	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:92616425C>A	uc001pdj.3	+	23	12820	c.12803C>A	c.(12802-12804)CCT>CAT	p.P4268H	FAT3_uc001pdi.3_Missense_Mutation_p.P708H	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4268	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ACGTTTCACCCTGAGTCGCCC	0.657			NA								TCGA Ovarian(4;0.039)			18	117					1.56452e-12	2.43161e-12	0.007413	1	0
DYNC2H1	79659	broad.mit.edu	37	11	103057207	103057207	+	Silent	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:103057207A>T	uc001pho.2	+	42	7014	c.6870A>T	c.(6868-6870)GTA>GTT	p.V2290V	DYNC2H1_uc001phn.1_Silent_p.V2290V|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2290	AAA 3 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TTATTCTGGTAGGACCAGAAG	0.393			NA											4	19					0	0	0.009096	0	0
PDGFD	80310	broad.mit.edu	37	11	103797775	103797775	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:103797775C>A	uc001phq.2	-	6	1224	c.852G>T	c.(850-852)GAG>GAT	p.E284D	PDGFD_uc001php.2_Missense_Mutation_p.E278D	NM_025208	NP_079484	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D isoform 1	284					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		CCAACTTCAGCTCTTCTCTTA	0.488			NA											7	46					0.000157383	0.00018675	0.00308	1	0
CRYAB	1410	broad.mit.edu	37	11	111779603	111779603	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:111779603G>A	uc001pmf.1	-	3	438	c.413C>T	c.(412-414)TCA>TTA	p.S138L		NM_001885	NP_001876	P02511	CRYAB_HUMAN	crystallin, alpha B	138					anti-apoptosis|muscle contraction|negative regulation of intracellular transport|protein folding|protein homooligomerization|response to heat	cytoplasm|nucleus	protein homodimerization activity|structural constituent of eye lens|unfolded protein binding				0		all_cancers(61;1.26e-15)|all_epithelial(67;9.52e-10)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.57e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|all cancers(92;6.57e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.051)		CCCATCAGATGACAGGGATGA	0.527			NA											6	64					0	0	0.001168	0	0
HTR3B	9177	broad.mit.edu	37	11	113775684	113775684	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:113775684G>A	uc001pok.2	+	1	96	c.29G>A	c.(28-30)TGG>TAG	p.W10*		NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	10					synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		GCTCCCCTGTGGGCCTGCATC	0.433			NA											5	53					0	0	0.001984	0	0
CXCR5	643	broad.mit.edu	37	11	118764836	118764836	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:118764836C>T	uc001pue.3	+	2	693	c.583C>T	c.(583-585)CAC>TAC	p.H195Y	CXCR5_uc001puf.2_Missense_Mutation_p.H150Y	NM_001716	NP_001707	P32302	CXCR5_HUMAN	Burkitt lymphoma receptor 1 isoform 1	195	Extracellular (Potential).				B cell activation|cellular component movement	integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		CCAAGGCCATCACAACAACTC	0.572			NA											4	34					0	0	0.009096	0	0
MCAM	4162	broad.mit.edu	37	11	119183321	119183321	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:119183321C>A	uc001pwf.2	-	7	806	c.777G>T	c.(775-777)GTG>GTT	p.V259V	MCAM_uc001pwg.1_5'Flank	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	259	Ig-like C2-type 1.|Extracellular (Potential).				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		TCAGCATTCCCACGGGCTCCA	0.582			NA											8	92					5.18039e-06	6.79926e-06	0.00308	1	0
RNF26	79102	broad.mit.edu	37	11	119206115	119206115	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:119206115G>A	uc001pwh.2	+	1	879	c.283G>A	c.(283-285)GAG>AAG	p.E95K		NM_032015	NP_114404	Q9BY78	RNF26_HUMAN	ring finger protein 26	95	Leu-rich.						zinc ion binding			ovary(1)	1		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.8e-05)		CTCTGGCCTAGAGAGCCTAAA	0.602			NA											26	167					0	0	0.005443	0	0
GRIK4	2900	broad.mit.edu	37	11	120776177	120776177	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:120776177G>T	uc001pxn.2	+	13	1738	c.1451G>T	c.(1450-1452)GGA>GTA	p.G484V	GRIK4_uc009zav.1_Missense_Mutation_p.G484V|GRIK4_uc009zaw.1_Missense_Mutation_p.G484V|GRIK4_uc009zax.1_Missense_Mutation_p.G484V	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	484	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	ACCTGGACGGGAATGGTCGGG	0.602			NA											22	107					1.10923e-09	1.65014e-09	0.00278	1	0
TECTA	7007	broad.mit.edu	37	11	120998690	120998690	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:120998690G>T	uc010rzo.1	+	8	2004	c.2004G>T	c.(2002-2004)ACG>ACT	p.T668T		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	668					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TCTGGGCCACGGCCAACTGCA	0.647			NA											8	45					1.26484e-09	1.86932e-09	0.00308	1	0
OR10G8	219869	broad.mit.edu	37	11	123900895	123900895	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:123900895C>A	uc001pzp.1	+	1	566	c.566C>A	c.(565-567)GCA>GAA	p.A189E		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CTGGCCTGTGCAGACACCTCA	0.512			NA											26	145					2.27525e-19	3.79069e-19	0.003954	1	0
OR8D2	283160	broad.mit.edu	37	11	124189498	124189498	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:124189498A>T	uc010sah.1	-	1	596	c.596T>A	c.(595-597)CTG>CAG	p.L199Q		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		AATAATGAACAGCAGAATCTC	0.403			NA											9	61					0	0	0.004482	0	0
NFRKB	4798	broad.mit.edu	37	11	129746672	129746672	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:129746672C>A	uc001qfi.2	-	17	1892	c.1691G>T	c.(1690-1692)CGG>CTG	p.R564L	NFRKB_uc001qfg.2_Missense_Mutation_p.R589L|NFRKB_uc001qfh.2_Missense_Mutation_p.R587L|NFRKB_uc010sbw.1_Missense_Mutation_p.R574L|NFRKB_uc009zcr.2_5'Flank	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	564					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		GGAGTGCTCCCGAGCCTTGTT	0.582			NA											15	54					0.000422831	0.000489509	0.004007	1	0
NTM	50863	broad.mit.edu	37	11	132016339	132016339	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:132016339G>T	uc001qgp.2	+	2	995	c.331G>T	c.(331-333)GGC>TGC	p.G111C	NTM_uc001qgm.2_Missense_Mutation_p.G111C|NTM_uc010sch.1_Missense_Mutation_p.G102C|NTM_uc010sci.1_Missense_Mutation_p.G111C|NTM_uc010scj.1_Missense_Mutation_p.G70C|NTM_uc001qgo.2_Missense_Mutation_p.G111C|NTM_uc001qgq.2_Missense_Mutation_p.G111C	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	111	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						GTATGACGAGGGCCCTTACAC	0.577			NA											7	41					0.000157383	0.00018675	0.00308	1	0
IQSEC3	440073	broad.mit.edu	37	12	272696	272696	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:272696A>G	uc001qhw.1	+	6	1717	c.1711A>G	c.(1711-1713)AGC>GGC	p.S571G	IQSEC3_uc001qhu.1_Missense_Mutation_p.S571G	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	874	PH.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		GGTGTGCTGCAGCCGGCTCTT	0.672			NA											18	61					0	0	0.008871	0	0
SLC6A12	6539	broad.mit.edu	37	12	305962	305962	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:305962G>A	uc001qhz.2	-	12	1705	c.1162C>T	c.(1162-1164)CTC>TTC	p.L388F	SLC6A12_uc001qhx.2_Missense_Mutation_p.L45F|SLC6A12_uc001qhy.2_Intron|SLC6A12_uc001qia.2_Missense_Mutation_p.L388F|SLC6A12_uc001qib.2_Missense_Mutation_p.L388F|SLC6A12_uc009zdh.1_Missense_Mutation_p.L388F	NM_003044	NP_003035	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter	388	Helical; Name=8; (Potential).				cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			AGGAATATGAGCATGATAAAG	0.572			NA											7	92					0	0	0.001984	0	0
ANO2	57101	broad.mit.edu	37	12	5724394	5724394	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:5724394T>C	uc001qnm.2	-	18	1958	c.1886A>G	c.(1885-1887)AAT>AGT	p.N629S		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	634	Helical; (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						GGAGTAGGCATTGACAAACTT	0.448			NA											3	42					0	0	0.004672	0	0
MRPL51	51258	broad.mit.edu	37	12	6602071	6602071	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:6602071C>G	uc001qom.2	-	2	316	c.147G>C	c.(145-147)GAG>GAC	p.E49D	MRPL51_uc001qon.1_RNA|NCAPD2_uc009zen.1_5'Flank|NCAPD2_uc001qoo.2_5'Flank|NCAPD2_uc010sfd.1_5'Flank	NM_016497	NP_057581	Q4U2R6	RM51_HUMAN	mitochondrial ribosomal protein L51 precursor	49					translation	mitochondrial large ribosomal subunit	protein binding|structural constituent of ribosome				0						TGGCCCTTTTCTCGTTCCAAC	0.507			NA											6	94					0	0	0.004482	0	0
CD163L1	283316	broad.mit.edu	37	12	7548878	7548878	+	Nonsense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:7548878A>T	uc001qsy.2	-	8	1889	c.1863T>A	c.(1861-1863)TGT>TGA	p.C621*	CD163L1_uc010sge.1_Nonsense_Mutation_p.C631*	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	621	SRCR 6.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						CCAGCTGGCTACACACCACAG	0.527			NA											11	23					0	0	0.000978	0	0
CLEC4D	338339	broad.mit.edu	37	12	8672847	8672847	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:8672847G>A	uc001qun.2	+	5	603	c.410G>A	c.(409-411)AGA>AAA	p.R137K		NM_080387	NP_525126	Q8WXI8	CLC4D_HUMAN	C-type lectin domain family 4, member D	137	C-type lectin.|Extracellular (Potential).				innate immune response	integral to membrane	sugar binding				0	Lung SC(5;0.184)					TTTCTGGATAGACGGCTTTCC	0.383			NA											8	75					0	0	0.00308	0	0
CLEC1B	51266	broad.mit.edu	37	12	10145867	10145867	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:10145867C>T	uc001qwu.2	-	6	765	c.565G>A	c.(565-567)GGA>AGA	p.G189R	CLEC1B_uc009zhd.2_Missense_Mutation_p.G156R	NM_016509	NP_057593	Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B isoform	189	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity				0						TTTCCTTTTCCATCTTCCAAA	0.353			NA											11	66					0	0	0.008291	0	0
GPR19	2842	broad.mit.edu	37	12	12814875	12814875	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:12814875G>A	uc001rar.3	-	2	701	c.508C>T	c.(508-510)CCT>TCT	p.P170S	GPR19_uc001raq.2_Missense_Mutation_p.P170S	NM_006143	NP_006134	Q15760	GPR19_HUMAN	G protein-coupled receptor 19	170	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.048)		AAGCTCAGAGGATAGACGATG	0.473			NA											28	76					0	0	0.002445	0	0
GPR19	2842	broad.mit.edu	37	12	12815044	12815044	+	Silent	SNP	G	G	A	rs143793074		TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:12815044G>A	uc001rar.3	-	2	532	c.339C>T	c.(337-339)CTC>CTT	p.L113L	GPR19_uc001raq.2_Silent_p.L113L	NM_006143	NP_006134	Q15760	GPR19_HUMAN	G protein-coupled receptor 19	113	Helical; Name=2; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.048)		CAACGCTGATGAGAAGGTCAG	0.512			NA											12	43					0	0	0.000978	0	0
GPR19	2842	broad.mit.edu	37	12	12815046	12815046	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:12815046G>A	uc001rar.3	-	2	530	c.337C>T	c.(337-339)CTC>TTC	p.L113F	GPR19_uc001raq.2_Missense_Mutation_p.L113F	NM_006143	NP_006134	Q15760	GPR19_HUMAN	G protein-coupled receptor 19	113	Helical; Name=2; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.048)		ACGCTGATGAGAAGGTCAGCA	0.507			NA											11	45					0	0	0.000978	0	0
GPR19	2842	broad.mit.edu	37	12	12815116	12815116	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:12815116G>A	uc001rar.3	-	2	460	c.267C>T	c.(265-267)GTC>GTT	p.V89V	GPR19_uc001raq.2_Silent_p.V89V	NM_006143	NP_006134	Q15760	GPR19_HUMAN	G protein-coupled receptor 19	89	Helical; Name=1; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.048)		TCCTATGGATGACCAAACAAA	0.507			NA											15	52					0	0	0.004007	0	0
GPR19	2842	broad.mit.edu	37	12	12815160	12815160	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:12815160G>A	uc001rar.3	-	2	416	c.223C>T	c.(223-225)CTG>TTG	p.L75L	GPR19_uc001raq.2_Silent_p.L75L	NM_006143	NP_006134	Q15760	GPR19_HUMAN	G protein-coupled receptor 19	75	Helical; Name=1; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.048)		AACAACCACAGAATCCCAAAG	0.488			NA											21	73					0	0	0.008871	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21422677	21422677	+	Silent	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:21422677T>A	uc001rer.2	-	14	2069	c.1818A>T	c.(1816-1818)GCA>GCT	p.A606A	SLCO1A2_uc001res.2_Silent_p.A606A|SLCO1A2_uc010siq.1_Silent_p.A474A|SLCO1A2_uc010sio.1_Silent_p.A474A|SLCO1A2_uc010sip.1_Silent_p.A474A	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	606	Helical; Name=12; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						CTCTTAGTGCTGCCGGCAATC	0.343			NA											4	27					0	0	0.001168	0	0
KCNJ8	3764	broad.mit.edu	37	12	21919187	21919187	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:21919187G>C	uc001rff.2	-	3	1083	c.745C>G	c.(745-747)CCT>GCT	p.P249A		NM_004982	NP_004973	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel J8	249	Cytoplasmic (By similarity).					voltage-gated potassium channel complex					0					Levosimendan(DB00922)	TTATCAACAGGAATGTCCAGT	0.483			NA											18	45					0	0	0.00499	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			5	27					0.00198382	0.00221159	0.001984	1	0
TMTC1	83857	broad.mit.edu	37	12	29908738	29908738	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:29908738C>A	uc001rjb.2	-	4	785	c.311G>T	c.(310-312)GGG>GTG	p.G104V	TMTC1_uc001rjc.1_Missense_Mutation_p.G104V	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	212	Helical; (Potential).					integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					CGCACAGGTCCCCAGAAACAA	0.493			NA											11	55					9.70103e-10	1.44555e-09	0.008291	1	0
DENND5B	160518	broad.mit.edu	37	12	31632962	31632962	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:31632962C>A	uc001rki.1	-	3	651	c.465G>T	c.(463-465)ATG>ATT	p.M155I	DENND5B_uc001rkh.1_Missense_Mutation_p.M190I|DENND5B_uc009zjq.1_Missense_Mutation_p.M74I|DENND5B_uc001rkj.2_Missense_Mutation_p.M177I|DENND5B_uc001rkk.1_Missense_Mutation_p.M77I	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	155						integral to membrane				ovary(1)|central_nervous_system(1)	2						CCAATGAGTCCATACTGCAGG	0.423			NA											13	86					1.49906e-05	1.90119e-05	0.00245	1	0
FGD4	121512	broad.mit.edu	37	12	32751515	32751515	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:32751515G>C	uc001rkz.2	+	5	1162	c.685G>C	c.(685-687)GAT>CAT	p.D229H	FGD4_uc001rlc.2_Missense_Mutation_p.D314H|FGD4_uc001rky.2_5'UTR|FGD4_uc001rla.2_5'UTR|FGD4_uc010ske.1_Missense_Mutation_p.D341H|FGD4_uc001rlb.1_RNA	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	229	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					TGACCTCTTAGATCAGGTAAG	0.313			NA											23	76					0	0	0.00278	0	0
CPNE8	144402	broad.mit.edu	37	12	39064600	39064600	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:39064600C>G	uc001rls.1	-	19	1521	c.1437G>C	c.(1435-1437)ATG>ATC	p.M479I	CPNE8_uc001rlr.1_Missense_Mutation_p.M138I	NM_153634	NP_705898	Q86YQ8	CPNE8_HUMAN	copine VIII	479	VWFA.									pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				CCAATTCGACCATTGCTTTAA	0.328			NA											7	29					0	0	0.001984	0	0
PDZRN4	29951	broad.mit.edu	37	12	41967324	41967324	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:41967324G>T	uc010skn.1	+	10	2214	c.2146G>T	c.(2146-2148)GCC>TCC	p.A716S	PDZRN4_uc001rmq.3_Missense_Mutation_p.A657S|PDZRN4_uc009zjz.2_Missense_Mutation_p.A655S|PDZRN4_uc001rmr.2_Missense_Mutation_p.A542S	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	915							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GAAGGAACGTGCCTTAAAGAT	0.517			NA											14	53					1.49906e-05	1.90119e-05	0.00245	1	0
HDAC7	51564	broad.mit.edu	37	12	48190850	48190850	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:48190850T>C	uc009zkv.1	-	5	751	c.536A>G	c.(535-537)AAG>AGG	p.K179R	HDAC7_uc010slo.1_Missense_Mutation_p.K218R|HDAC7_uc001rqj.3_Missense_Mutation_p.K218R|HDAC7_uc001rqk.3_Missense_Mutation_p.K201R			Q8WUI4	HDAC7_HUMAN	Synthetic construct DNA, clone: pF1KB0470, Homo sapiens HDAC7 gene for histone deacetylase 7, without stop codon, in Flexi system.	179	Transcription repression 1 (By similarity).				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.137)		CGCACTCTCCTTTCGGAGCAG	0.652			NA											7	56					0	0	0.001984	0	0
OR8S1	341568	broad.mit.edu	37	12	48919816	48919816	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:48919816G>T	uc010slu.1	+	1	402	c.402G>T	c.(400-402)CAG>CAT	p.Q134H		NM_001005203	NP_001005203	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S,	134	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TTTATGGACAGATCATGGGTA	0.522			NA											18	69					1.01871e-10	1.53572e-10	0.008871	1	0
MLL2	8085	broad.mit.edu	37	12	49420271	49420271	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:49420271C>G	uc001rta.3	-	48	15478	c.15478G>C	c.(15478-15480)GAC>CAC	p.D5160H		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5160					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding	p.I5160M(1)		kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TTCACCTCGTCCCGCTCAATG	0.572			NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			18	35					0	0	0.007413	0	0
SMARCD1	6602	broad.mit.edu	37	12	50492589	50492589	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:50492589C>G	uc001rvx.3	+	12	1655	c.1485C>G	c.(1483-1485)TTC>TTG	p.F495L	SMARCD1_uc001rvy.3_Missense_Mutation_p.F454L|SMARCD1_uc009zlp.2_Missense_Mutation_p.F454L	NM_003076	NP_003067	Q96GM5	SMRD1_HUMAN	SWI/SNF-related matrix-associated	495	Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin; required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo.				chromatin-mediated maintenance of transcription|nervous system development|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	protein complex scaffold|transcription coactivator activity			ovary(1)	1						GCCGATACTTCTACTCCAAGG	0.552			NA											4	39					0	0	0.009096	0	0
DIP2B	57609	broad.mit.edu	37	12	51138374	51138374	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:51138374G>T	uc001rwv.2	+	38	4639	c.4483G>T	c.(4483-4485)GTG>TTG	p.V1495L	DIP2B_uc009zlt.2_Missense_Mutation_p.V925L	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	1495						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						TTTCAGTGCCGTGTTCACATG	0.463			NA											16	78					4.7546e-09	6.8915e-09	0.004007	1	0
ANKRD33	341405	broad.mit.edu	37	12	52284753	52284753	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:52284753C>A	uc001rzf.3	+	5	1227	c.648C>A	c.(646-648)TCC>TCA	p.S216S	ANKRD33_uc001rzh.3_3'UTR|ANKRD33_uc001rzd.2_Silent_p.S341S|ANKRD33_uc001rze.2_Silent_p.S237S|ANKRD33_uc001rzg.3_Silent_p.S143S|ANKRD33_uc001rzi.3_Silent_p.S216S	NM_001130015	NP_001123487	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33 isoform 1	216											0				BRCA - Breast invasive adenocarcinoma(357;0.0969)		GAAGCAAGTCCGTGCCAGAGC	0.657			NA											10	24					1.58986e-06	2.13004e-06	0.008291	1	0
LACRT	90070	broad.mit.edu	37	12	55024687	55024687	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:55024687G>A	uc001sgi.1	-	5	444	c.406C>T	c.(406-408)CCA>TCA	p.P136S		NM_033277	NP_150593	Q9GZZ8	LACRT_HUMAN	lacritin precursor	136					calcineurin-NFAT signaling pathway|positive regulation of epithelial cell proliferation|positive regulation of NFAT protein import into nucleus|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of secretion|protein localization in Golgi apparatus|tear secretion	extracellular region|stored secretory granule	collagen binding|fibronectin binding|glycoprotein binding|growth factor activity|laminin-1 binding|protein N-terminus binding			central_nervous_system(1)	1						CATGCCCATGGTTTTAATAGA	0.403			NA											5	35					0	0	0.000602	0	0
OR6C1	390321	broad.mit.edu	37	12	55715183	55715183	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:55715183C>T	uc010spi.1	+	1	800	c.800C>T	c.(799-801)TCC>TTC	p.S267F		NM_001005182	NP_001005182	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2						GATAGAGTGTCCTTGAGCAAG	0.428			NA											10	135					0	0	0.006214	0	0
SMARCC2	6601	broad.mit.edu	37	12	56563372	56563372	+	Missense_Mutation	SNP	C	C	T	rs144543721	byFrequency	TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:56563372C>T	uc001skb.2	-	24	2669	c.2563G>A	c.(2563-2565)GAG>AAG	p.E855K	SMARCC2_uc001skd.2_Missense_Mutation_p.E886K|SMARCC2_uc001ska.2_Missense_Mutation_p.E886K|SMARCC2_uc001skc.2_Missense_Mutation_p.E885K|SMARCC2_uc010sqf.1_Missense_Mutation_p.E775K	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	855	Glu-rich.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			AGGTTGCCCTCGCCAATGtcc	0.189			NA											4	41					0	0	0.009096	0	0
LRP1	4035	broad.mit.edu	37	12	57588394	57588394	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:57588394C>T	uc001snd.2	+	50	8569	c.8103C>T	c.(8101-8103)TTC>TTT	p.F2701F		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	2701	LDL-receptor class A 15.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGAATTACTTCGCCTGCCCTA	0.632			NA											13	49					0	0	0.001855	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57872492	57872492	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:57872492G>T	uc001sod.2	-	6	771	c.578C>A	c.(577-579)CCA>CAA	p.P193Q	ARHGAP9_uc001snz.2_5'Flank|ARHGAP9_uc001soa.2_5'Flank|ARHGAP9_uc001sob.2_Missense_Mutation_p.P122Q|ARHGAP9_uc001soc.2_Missense_Mutation_p.P122Q|ARHGAP9_uc001soe.1_Missense_Mutation_p.P201Q|ARHGAP9_uc010sro.1_Missense_Mutation_p.P122Q	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	122					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			AGCCCTGCTTGGGAGGGCCTG	0.577			NA											9	95					3.86212e-05	4.77085e-05	0.008291	1	0
CYP27B1	1594	broad.mit.edu	37	12	58158802	58158802	+	Missense_Mutation	SNP	A	A	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:58158802A>C	uc001spz.1	-	4	934	c.782T>G	c.(781-783)TTT>TGT	p.F261C	CYP27B1_uc001sqa.1_Missense_Mutation_p.F26C|CYP27B1_uc001sqb.1_Silent_p.V141V|CYP27B1_uc001sqc.1_Silent_p.V141V	NM_000785	NP_000776	O15528	CP27B_HUMAN	cytochrome P450, family 27, subfamily B,	261					bone mineralization|calcium ion homeostasis|calcium ion transport|decidualization|G1 to G0 transition|hormone biosynthetic process|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of keratinocyte differentiation|positive regulation of vitamin D 24-hydroxylase activity|positive regulation of vitamin D receptor signaling pathway|regulation of bone mineralization|response to estrogen stimulus|response to interferon-gamma|response to lipopolysaccharide|response to tumor necrosis factor|response to vitamin D|vitamin D biosynthetic process|xenobiotic metabolic process	mitochondrial outer membrane	calcidiol 1-monooxygenase activity|electron carrier activity|heme binding			central_nervous_system(3)	3	all_cancers(7;8.09e-80)|Lung NSC(6;2.26e-27)|all_lung(6;1.99e-25)|all_epithelial(6;3.62e-18)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;1.97e-113)|all cancers(5;1.54e-78)|BRCA - Breast invasive adenocarcinoma(9;0.0294)		Calcidiol(DB00146)|Calcitriol(DB00136)|Ergocalciferol(DB00153)	ACCAAATGCAAACATCTGGTC	0.602			NA									OREG0021953	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	114					0	0	0.004007	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72004836	72004836	+	Splice_Site	SNP	A	A	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:72004836A>C	uc001swo.2	-	33	6128	c.5769_splice	c.e33+1	p.E1923_splice		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2						RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						ACCATGGCTTACCTCTCTTTG	0.259			NA											15	133					0	0	0.010504	0	0
KCNC2	3747	broad.mit.edu	37	12	75434879	75434879	+	Nonstop_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:75434879A>T	uc009zry.2	-	4	1907	c.1888T>A	c.(1888-1890)TGA>AGA	p.*630R	KCNC2_uc001sxe.2_3'UTR|KCNC2_uc001sxf.2_3'UTR	NM_139136	NP_631874	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	630	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						TGGTCACATCAGGGCACATTC	0.463			NA											8	51					0	0	0.00308	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85449828	85449828	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:85449828G>T	uc001tac.2	+	8	1368	c.1257G>T	c.(1255-1257)AAG>AAT	p.K419N	LRRIQ1_uc001tab.1_Missense_Mutation_p.K419N|LRRIQ1_uc001taa.1_Missense_Mutation_p.K394N	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	419										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		CAAATGATAAGGGTGATATAG	0.318			NA											6	59					8.12818e-05	9.7994e-05	0.001984	1	0
ALX1	8092	broad.mit.edu	37	12	85677633	85677633	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:85677633G>A	uc001tae.3	+	2	514	c.510G>A	c.(508-510)GAG>GAA	p.E170E		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	170	Homeobox.				brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		TGAGGACAGAGCTCACTGAGG	0.463			NA											28	70					0	0	0.007291	0	0
CEP290	80184	broad.mit.edu	37	12	88483117	88483117	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:88483117T>C	uc001tar.2	-	31	4065	c.3721A>G	c.(3721-3723)AAA>GAA	p.K1241E	CEP290_uc001taq.2_Missense_Mutation_p.K301E	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	1241	Potential.				cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						TCATCAAGTTTCTGCTCTAAG	0.438			NA											5	61					0	0	0.000602	0	0
C12orf74	338809	broad.mit.edu	37	12	93100630	93100630	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:93100630G>A	uc001tch.1	+	2	453	c.223G>A	c.(223-225)GGA>AGA	p.G75R	C12orf74_uc001tci.2_Missense_Mutation_p.G75R	NM_001037671	NP_001032760	Q32Q52	CL074_HUMAN	hypothetical protein LOC338809	75											0						GGGAAGCTGGGGAGCTCCTGT	0.582			NA											19	53					0	0	0.008871	0	0
NR2C1	7181	broad.mit.edu	37	12	95453709	95453709	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:95453709A>G	uc001tdm.3	-	4	593	c.337T>C	c.(337-339)TGC>CGC	p.C113R	NR2C1_uc010suu.1_Missense_Mutation_p.C113R|NR2C1_uc001tdo.3_Missense_Mutation_p.C113R|NR2C1_uc001tdn.3_Missense_Mutation_p.C113R	NM_003297	NP_003288	P13056	NR2C1_HUMAN	nuclear receptor subfamily 2, group C, member 1	113	Nuclear receptor.|Required for interaction with KAT2B (By similarity).|NR C4-type.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	PML body	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1						CATACTACGCAAAGATCAAAA	0.294			NA											10	52					0	0	0.006214	0	0
PTPN11	5781	broad.mit.edu	37	12	112891116	112891116	+	Silent	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:112891116T>C	uc001ttx.2	+	4	830	c.450T>C	c.(448-450)TCT>TCC	p.S150S	PTPN11_uc001ttw.1_Silent_p.S150S	NM_002834	NP_002825	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type	150	SH2 2.				axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding			haematopoietic_and_lymphoid_tissue(375)|lung(6)|autonomic_ganglia(2)|soft_tissue(2)|central_nervous_system(2)|large_intestine(1)|skin(1)|ovary(1)|NS(1)|kidney(1)	392						TTGTTCTTTCTGTGCGCACTG	0.433			NA	Mis		JMML|AML|MDS		Noonan Syndrome		Noonan_syndrome				21	154					0	0	0.002299	0	0
SDSL	113675	broad.mit.edu	37	12	113875723	113875723	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:113875723G>T	uc001tvi.2	+	9	1039	c.829G>T	c.(829-831)GGG>TGG	p.G277W	SDSL_uc009zwh.2_Missense_Mutation_p.G277W	NM_138432	NP_612441	Q96GA7	SDSL_HUMAN	serine dehydratase-like	277					cellular amino acid metabolic process		L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|pyridoxal phosphate binding				0					Pyridoxal Phosphate(DB00114)	GCCTGCCTGTGGGGCAGCCTT	0.617			NA											38	405					1.69901e-12	2.63609e-12	0.005524	1	0
NCOR2	9612	broad.mit.edu	37	12	124824973	124824973	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:124824973C>G	uc010tba.1	-	36	5496	c.5379G>C	c.(5377-5379)TTG>TTC	p.L1793F	NCOR2_uc010tay.1_Missense_Mutation_p.L1792F|NCOR2_uc010taz.1_Missense_Mutation_p.L1776F|NCOR2_uc010tbb.1_Missense_Mutation_p.L1785F|NCOR2_uc010tbc.1_Missense_Mutation_p.L1775F|NCOR2_uc010tax.1_5'Flank	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	1793					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TTGGTTTTGTCAAGTGTGTTG	0.612			NA											3	42					0	0	0.004672	0	0
TMEM132D	121256	broad.mit.edu	37	12	129822344	129822344	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:129822344G>T	uc009zyl.1	-	4	1462	c.1134C>A	c.(1132-1134)TAC>TAA	p.Y378*		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	378	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GCATGACCTCGTAGGAGGCGC	0.607			NA											45	133					1.48734e-19	2.48256e-19	0.003214	1	0
MPHOSPH8	54737	broad.mit.edu	37	13	20237249	20237249	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr13:20237249G>A	uc001umh.2	+	9	2011	c.2002G>A	c.(2002-2004)GAG>AAG	p.E668K	MPHOSPH8_uc001umg.2_Missense_Mutation_p.E668K	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	668	ANK 3.				cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		AAGCAATGGTGAGACTGCACT	0.438			NA											31	146					0	0	0.004289	0	0
USPL1	10208	broad.mit.edu	37	13	31232508	31232508	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr13:31232508G>T	uc001utc.2	+	9	2726	c.2294G>T	c.(2293-2295)AGC>ATC	p.S765I	USPL1_uc001utd.2_Missense_Mutation_p.S436I|USPL1_uc001ute.1_Missense_Mutation_p.S436I	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	765					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		GGCTTAATAAGCAGGGGTGCT	0.378	Ovarian(60;318 1180 1554 28110 31601)		NA											43	133					1.41504e-22	2.38391e-22	0.002852	1	0
HSPH1	10808	broad.mit.edu	37	13	31724148	31724148	+	Missense_Mutation	SNP	T	T	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr13:31724148T>G	uc001utj.2	-	8	1478	c.1080A>C	c.(1078-1080)AAA>AAC	p.K360N	HSPH1_uc001utk.2_Missense_Mutation_p.K360N|HSPH1_uc010aaw.2_Missense_Mutation_p.K319N|HSPH1_uc001utl.2_Missense_Mutation_p.K362N|HSPH1_uc010tds.1_Missense_Mutation_p.K284N|HSPH1_uc010tdt.1_RNA	NM_006644	NP_006635	Q92598	HS105_HUMAN	heat shock 105kD	360					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		TGCTAATATCTTTTCCAAAGA	0.408			NA											18	80					0	0	0.007413	0	0
NBEA	26960	broad.mit.edu	37	13	35684977	35684977	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr13:35684977G>T	uc001uvb.2	+	14	2070	c.1864G>T	c.(1864-1866)GCT>TCT	p.A622S		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	622						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		ATATTTGTCTGCTGAATTTAT	0.328			NA											4	19					0.00024832	0.000291212	0.009096	1	0
DCLK1	9201	broad.mit.edu	37	13	36401822	36401822	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr13:36401822C>A	uc001uvf.2	-	10	1590	c.1357G>T	c.(1357-1359)GAG>TAG	p.E453*	DCLK1_uc001uve.3_Nonsense_Mutation_p.E146*|DCLK1_uc010teh.1_Nonsense_Mutation_p.E146*|DCLK1_uc010abk.2_Intron	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	453	Protein kinase.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		TCCATCTCCTCAATCAGAAGA	0.393			NA											13	85					0.00010058	0.000120616	0.001368	1	0
FREM2	341640	broad.mit.edu	37	13	39263777	39263777	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr13:39263777A>T	uc001uwv.2	+	1	2605	c.2296A>T	c.(2296-2298)AAC>TAC	p.N766Y		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	766	CSPG 4.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CTTGACTGACAACCCCTCAGT	0.532			NA											3	53					0	0	0.009096	0	0
NAA16	79612	broad.mit.edu	37	13	41933097	41933097	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr13:41933097G>T	uc001uyf.2	+	12	1733	c.1409G>T	c.(1408-1410)AGG>ATG	p.R470M	NAA16_uc010tfg.1_RNA	NM_024561	NP_078837	Q6N069	NAA16_HUMAN	NMDA receptor regulated 1-like protein isoform	470					N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			central_nervous_system(1)	1						AAGTTCACAAGGGTAGGAAAT	0.358			NA											19	61					5.26018e-13	8.2896e-13	0.001882	1	0
LRCH1	23143	broad.mit.edu	37	13	47279214	47279214	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr13:47279214A>G	uc001vbj.2	+	12	1648	c.1412A>G	c.(1411-1413)GAT>GGT	p.D471G	LRCH1_uc010acp.2_Missense_Mutation_p.D471G|LRCH1_uc001vbk.2_Missense_Mutation_p.D471G|LRCH1_uc001vbl.3_Missense_Mutation_p.D471G	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	471										ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		TTAAGCACAGATATTACAGAG	0.274			NA											4	83					0	0	0.009096	0	0
PCDH17	27253	broad.mit.edu	37	13	58209170	58209170	+	Silent	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr13:58209170G>C	uc001vhq.1	+	1	3382	c.2490G>C	c.(2488-2490)GCG>GCC	p.A830A	PCDH17_uc010aec.1_Silent_p.A830A	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	830	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AGGGGCACGCGGGCTGCCACA	0.592	Melanoma(72;952 1291 1619 12849 33676)		NA											5	19					0	0	0.000602	0	0
MYCBP2	23077	broad.mit.edu	37	13	77786258	77786258	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr13:77786258T>C	uc001vkf.2	-	23	3072	c.2981A>G	c.(2980-2982)TAT>TGT	p.Y994C	MYCBP2_uc010aev.2_Missense_Mutation_p.Y398C	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	994	RCC1 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TGCATTCCAATATGGCACATC	0.358			NA											13	52					0	0	0.00499	0	0
SCEL	8796	broad.mit.edu	37	13	78167670	78167670	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr13:78167670C>T	uc001vki.2	+	12	884	c.714C>T	c.(712-714)ATC>ATT	p.I238I	SCEL_uc001vkj.2_Intron|SCEL_uc010thx.1_Silent_p.I216I	NM_144777	NP_659001	O95171	SCEL_HUMAN	sciellin isoform 1	238					embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			ovary(4)|breast(1)	5		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		TTGATAACATCGTCAAAGTGG	0.373			NA											6	64					0	0	0.00308	0	0
TGDS	23483	broad.mit.edu	37	13	95231010	95231010	+	Silent	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr13:95231010T>A	uc001vlw.2	-	8	754	c.633A>T	c.(631-633)ATA>ATT	p.I211I	TGDS_uc001vlx.2_RNA	NM_014305	NP_055120	O95455	TGDS_HUMAN	TDP-glucose 4,6-dehydratase	211					cellular metabolic process		coenzyme binding|dTDP-glucose 4,6-dehydratase activity|protein binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					GTAGCAAAGATATAAATTTTG	0.269			NA											7	56					0	0	0.00308	0	0
PCCA	5095	broad.mit.edu	37	13	100925576	100925576	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr13:100925576C>G	uc001voo.2	+	12	1079	c.1041C>G	c.(1039-1041)TTC>TTG	p.F347L	PCCA_uc010aga.2_Missense_Mutation_p.F321L|PCCA_uc010tiz.1_Missense_Mutation_p.F347L	NM_000282	NP_000273	P05165	PCCA_HUMAN	propionyl-Coenzyme A carboxylase, alpha	347	ATP-grasp.|Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			skin(2)	2	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	ATTTTTATTTCTTGGAAATGA	0.413			NA											8	39					0	0	0.004482	0	0
TPP2	7174	broad.mit.edu	37	13	103290630	103290630	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr13:103290630C>A	uc001vpi.3	+	15	1981	c.1878C>A	c.(1876-1878)CTC>CTA	p.L626L		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	626					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CAGGTCCGCTCTTCAGAGTTC	0.403			NA											15	95					0.00316338	0.00348783	0.003163	1	0
ERCC5	2073	broad.mit.edu	37	13	103492148	103492148	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr13:103492148T>A	uc001vpu.1	+	9	1567	c.1445T>A	c.(1444-1446)ATG>AAG	p.M482K	BIVM_uc001vps.2_Missense_Mutation_p.M482K|BIVM_uc010agc.2_Missense_Mutation_p.M260K|BIVM_uc001vpv.2_Missense_Mutation_p.M253K	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	Error:Variant_position_missing_in_P28715_after_alignment					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TGGAAAAAGATGTCTAGTATC	0.453			NA	Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				20	186					0	0	0.010504	0	0
ERCC5	2073	broad.mit.edu	37	13	103514690	103514690	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr13:103514690T>A	uc001vpw.2	+	8	1634	c.1191T>A	c.(1189-1191)GAT>GAA	p.D397E	ERCC5_uc001vpu.1_Missense_Mutation_p.D851E|ERCC5_uc010tjb.1_Missense_Mutation_p.D397E|ERCC5_uc010tjc.1_RNA|ERCC5_uc010tjd.1_Missense_Mutation_p.D229E	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	397					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					CTCTTGACGATGACGAAGATG	0.527			NA	Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				5	55					0	0	0.00308	0	0
MYO16	23026	broad.mit.edu	37	13	109438076	109438076	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr13:109438076T>A	uc001vqt.1	+	5	661	c.535T>A	c.(535-537)TAT>AAT	p.Y179N	MYO16_uc010agk.1_Missense_Mutation_p.Y201N	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	179	ANK 4.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CCTGTTGACCTATCTGGATGA	0.378			NA											5	54					0	0	0.000602	0	0
MYO16	23026	broad.mit.edu	37	13	109753146	109753146	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr13:109753146G>C	uc001vqt.1	+	28	3409	c.3283G>C	c.(3283-3285)GCT>CCT	p.A1095P	MYO16_uc010agk.1_Missense_Mutation_p.A1117P|MYO16_uc010tjh.1_Missense_Mutation_p.A607P	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1095	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TAAGCCACTGGCTGATACATT	0.478			NA											5	27					0	0	0.000602	0	0
POTEG	404785	broad.mit.edu	37	14	19553819	19553819	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:19553819G>A	uc001vuz.1	+	1	455	c.403G>A	c.(403-405)GTC>ATC	p.V135I	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	135										ovary(1)	1						GAGGTACCACGTCCGTCGAGA	0.582			NA											7	271					0	0	0.003163	0	0
OR4K15	81127	broad.mit.edu	37	14	20444457	20444457	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:20444457C>A	uc010tkx.1	+	1	780	c.780C>A	c.(778-780)GCC>GCA	p.A260A		NM_001005486	NP_001005486	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K,	260	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGGCGAAGGCCCGCTCCACAT	0.463			NA											6	102					8.12818e-05	9.7994e-05	0.001984	1	0
OR11H4	390442	broad.mit.edu	37	14	20711609	20711609	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:20711609C>A	uc010tld.1	+	1	659	c.659C>A	c.(658-660)ACT>AAT	p.T220N		NM_001004479	NP_001004479	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H,	220	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		CTCTTTTTCACTAGTATGTAC	0.453			NA											23	248					7.41877e-09	1.06336e-08	0.001882	1	0
TEP1	7011	broad.mit.edu	37	14	20841524	20841524	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:20841524G>C	uc001vxe.2	-	47	6759	c.6719C>G	c.(6718-6720)CCA>CGA	p.P2240R	TEP1_uc010ahj.1_5'Flank|TEP1_uc010ahk.2_Missense_Mutation_p.P1583R|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.P2132R|TEP1_uc010tlh.1_Missense_Mutation_p.P578R	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	2240	WD 15.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AGCACGGACTGGGCCGCTGTG	0.577			NA											4	62					0	0	0.009096	0	0
TEP1	7011	broad.mit.edu	37	14	20841881	20841881	+	Nonsense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:20841881G>C	uc001vxe.2	-	45	6600	c.6560C>G	c.(6559-6561)TCA>TGA	p.S2187*	TEP1_uc010ahj.1_5'Flank|TEP1_uc010ahk.2_Nonsense_Mutation_p.S1530*|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Nonsense_Mutation_p.S2079*|TEP1_uc010tlh.1_Nonsense_Mutation_p.S525*	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	2187	WD 14.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AATGGGTCCTGAGTGAGCAGG	0.597			NA											3	71					0	0	0.009096	0	0
TEP1	7011	broad.mit.edu	37	14	20843947	20843947	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:20843947G>A	uc001vxe.2	-	43	6370	c.6330C>T	c.(6328-6330)GTC>GTT	p.V2110V	TEP1_uc010ahj.1_5'Flank|TEP1_uc010ahk.2_Silent_p.V1453V|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Silent_p.V2002V|TEP1_uc010tlh.1_Silent_p.V448V	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	2110	WD 12.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CACAGCCAGTGACCCAGTCAC	0.592			NA											5	48					0	0	0.00308	0	0
TEP1	7011	broad.mit.edu	37	14	20864787	20864787	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:20864787T>A	uc001vxe.2	-	10	1692	c.1652A>T	c.(1651-1653)CAG>CTG	p.Q551L	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.Q443L	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	551	TROVE.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		TACCGCATGCTGGAGTCTCTG	0.577			NA											5	21					0	0	0.000602	0	0
TEP1	7011	broad.mit.edu	37	14	20876171	20876171	+	Missense_Mutation	SNP	C	C	T	rs111250999		TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:20876171C>T	uc001vxe.2	-	2	468	c.428G>A	c.(427-429)CGT>CAT	p.R143H	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.R143H	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	143					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GTTGTTCACACGGTACAAATC	0.517			NA											10	139					0	0	0.000978	0	0
RNASE11	122651	broad.mit.edu	37	14	21052079	21052079	+	Silent	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:21052079T>A	uc010ahv.2	-	2	740	c.555A>T	c.(553-555)ACA>ACT	p.T185T	RNASE11_uc010ahx.2_Silent_p.T185T|RNASE11_uc010ahw.2_Silent_p.T185T|RNASE11_uc001vxs.2_Silent_p.T185T	NM_145250	NP_660293	Q8TAA1	RNS11_HUMAN	ribonuclease, RNase A family, 11 (non-active)	185						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(3)	3	all_cancers(95;0.00238)	all_lung(585;0.235)	Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.0139)		GAGAATGACCTGTCAGCACTG	0.428			NA											7	60					0	0	0.00308	0	0
OR6S1	341799	broad.mit.edu	37	14	21108870	21108870	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:21108870C>A	uc001vxv.1	-	1	981	c.981G>T	c.(979-981)GAG>GAT	p.E327D		NM_001001968	NP_001001968	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S,	327	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		TTACTGCTTTCTCACTGAGAC	0.274			NA											16	130					2.23348e-06	2.96158e-06	0.004007	1	0
RNASE13	440163	broad.mit.edu	37	14	21502310	21502310	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:21502310C>A	uc001vzj.2	-	2	276	c.138G>T	c.(136-138)AAG>AAT	p.K46N	NDRG2_uc010tll.1_Intron	NM_001012264	NP_001012264	Q5GAN3	RNS13_HUMAN	ribonuclease, RNase A family, 13 precursor	46						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			upper_aerodigestive_tract(1)	1	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.019)		CCCGGAAACCCTTTGGGTAGT	0.458			NA											18	107					1.50039e-11	2.30417e-11	0.001882	1	0
CHD8	57680	broad.mit.edu	37	14	21897346	21897346	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:21897346T>A	uc001was.1	-	3	249	c.155A>T	c.(154-156)CAA>CTA	p.Q52L	CHD8_uc001war.1_5'UTR	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	331	Gln-rich.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		AGGCTGCCCTTGGGCATTCTT	0.557			NA											5	46					0	0	0.000602	0	0
MYH7	4625	broad.mit.edu	37	14	23888489	23888489	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:23888489T>A	uc001wjx.2	-	29	3975	c.3869A>T	c.(3868-3870)CAG>CTG	p.Q1290L	MIR208B_hsa-mir-208b|MI0005570_5'Flank	NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1290	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CTCATCCAGCTGCCGGGACAG	0.597			NA											9	51					0	0	0.006214	0	0
CMA1	1215	broad.mit.edu	37	14	24976708	24976708	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:24976708C>G	uc001wpp.1	-	2	93	c.63G>C	c.(61-63)GAG>GAC	p.E21D	CMA1_uc010alx.1_Intron	NM_001836	NP_001827	P23946	CMA1_HUMAN	chymase 1, mast cell preproprotein	21					interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.0271)		CCCCGATGATCTCCCCTGGAA	0.507			NA											4	119					0	0	0.009096	0	0
COCH	1690	broad.mit.edu	37	14	31355160	31355160	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:31355160T>A	uc001wqr.2	+	11	1199	c.1119T>A	c.(1117-1119)GAT>GAA	p.D373E	COCH_uc001wqp.2_Missense_Mutation_p.D373E|COCH_uc001wqq.3_Missense_Mutation_p.D373E|uc001wqs.2_RNA|COCH_uc001wqt.1_Missense_Mutation_p.D224E	NM_004086	NP_004077	O43405	COCH_HUMAN	cochlin precursor	373	VWFA 2.				sensory perception of sound	proteinaceous extracellular matrix				pancreas(1)|central_nervous_system(1)|skin(1)	3	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		TTCTAATTGATGGCTCCAGCA	0.423			NA											6	81					0	0	0.001168	0	0
FNTB	2342	broad.mit.edu	37	14	65527989	65527989	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:65527989G>C	uc001xia.2	+	12	1438	c.1273G>C	c.(1273-1275)GAG>CAG	p.E425Q	FNTB_uc010tsl.1_Missense_Mutation_p.E459Q|FNTB_uc010tsm.1_Missense_Mutation_p.E379Q|MAX_uc001xic.1_Intron|FNTB_uc001xid.2_Missense_Mutation_p.E181Q|FNTB_uc010tso.1_Missense_Mutation_p.E340Q	NM_002028	NP_002019	P49356	FNTB_HUMAN	farnesyltransferase, CAAX box, beta	425					protein farnesylation	microtubule associated complex	protein binding|protein farnesyltransferase activity			ovary(1)	1				all cancers(60;0.00115)|OV - Ovarian serous cystadenocarcinoma(108;0.00412)|BRCA - Breast invasive adenocarcinoma(234;0.011)		AGGTTTTGAGGAGCTTAAGGA	0.532			NA											10	56					0	0	0.000978	0	0
GALNTL1	57452	broad.mit.edu	37	14	69787507	69787507	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:69787507A>G	uc010aqu.1	+	2	350	c.257A>G	c.(256-258)TAC>TGC	p.Y86C	GALNTL1_uc001xla.1_Missense_Mutation_p.Y86C|GALNTL1_uc001xlb.1_Missense_Mutation_p.Y86C	NM_020692	NP_065743	Q8N428	GLTL1_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	86	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(1)|central_nervous_system(1)	2				all cancers(60;0.00793)|BRCA - Breast invasive adenocarcinoma(234;0.0174)|OV - Ovarian serous cystadenocarcinoma(108;0.0656)		GAGGACCCCTACAGACAGCAC	0.587			NA											5	62					0	0	0.000602	0	0
KIAA0317	9870	broad.mit.edu	37	14	75142581	75142581	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:75142581G>C	uc001xqb.2	-	8	1406	c.901C>G	c.(901-903)CTT>GTT	p.L301V	KIAA0317_uc010tut.1_Missense_Mutation_p.L140V|KIAA0317_uc001xqc.2_Missense_Mutation_p.L301V	NM_001039479	NP_001034568	O15033	K0317_HUMAN	hypothetical protein LOC9870	301					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)		GCATTATAAAGATAAGCCTCA	0.468			NA											17	174					0	0	0.00499	0	0
C14orf1	11161	broad.mit.edu	37	14	76121288	76121288	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:76121288G>A	uc001xrt.2	-	3	611	c.165C>T	c.(163-165)ATC>ATT	p.I55I	C14orf1_uc001xru.2_RNA	NM_007176	NP_009107	Q9UKR5	ERG28_HUMAN	ergosterol biosynthetic protein 28	55	Helical; (Potential).				sterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|transport vesicle					0		all_epithelial(191;0.125)|all_neural(303;0.13)|Myeloproliferative disorder(585;0.163)		BRCA - Breast invasive adenocarcinoma(234;0.00147)		GCAGCGTCCAGATCCCAAAGG	0.478			NA									OREG0022817	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	45	179					0	0	0.003214	0	0
TTLL5	23093	broad.mit.edu	37	14	76349199	76349199	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:76349199A>T	uc001xrx.2	+	30	3899	c.3694A>T	c.(3694-3696)AAC>TAC	p.N1232Y	TTLL5_uc010ask.1_Missense_Mutation_p.N1247Y|TTLL5_uc001xrz.2_Missense_Mutation_p.N807Y|TTLL5_uc001xsa.2_Missense_Mutation_p.N306Y	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	1232					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		ACCCCCACCCAACCACGAACA	0.478			NA											6	52					0	0	0.001168	0	0
ZC3H14	79882	broad.mit.edu	37	14	89069242	89069242	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:89069242C>T	uc001xww.2	+	12	1810	c.1585C>T	c.(1585-1587)CCA>TCA	p.P529S	ZC3H14_uc010twd.1_Missense_Mutation_p.P529S|ZC3H14_uc010twe.1_Missense_Mutation_p.P529S|ZC3H14_uc001xwx.2_Intron|ZC3H14_uc010twf.1_Intron|ZC3H14_uc001xwy.2_Intron|ZC3H14_uc010twg.1_Intron|ZC3H14_uc001xxa.2_Missense_Mutation_p.P74S|ZC3H14_uc001xxc.2_Intron|ZC3H14_uc001xxb.2_Intron	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	529						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						CCCCAGCCCCCCAGGATACAT	0.468			NA											7	28					0	0	0.001984	0	0
KCNK13	56659	broad.mit.edu	37	14	90651285	90651285	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:90651285G>T	uc001xye.1	+	2	1607	c.1165G>T	c.(1165-1167)GGG>TGG	p.G389W		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	389	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				TGAATTCTCAGGGGGGGTGGG	0.587			NA											10	16					7.48243e-07	1.00996e-06	0.006214	1	0
TC2N	123036	broad.mit.edu	37	14	92251584	92251584	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:92251584T>C	uc001xzu.3	-	11	1475	c.1284A>G	c.(1282-1284)ATA>ATG	p.I428M	TC2N_uc001xzt.3_Missense_Mutation_p.I428M|TC2N_uc010auc.2_Missense_Mutation_p.I364M|TC2N_uc001xzv.3_Missense_Mutation_p.I428M	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	428	C2.					nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		TTTCACTCTGTATAAGTGGAA	0.383			NA											39	178					0	0	0.002522	0	0
SERPINA1	5265	broad.mit.edu	37	14	94849012	94849012	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:94849012C>T	uc001ycx.3	-	2	824	c.563G>A	c.(562-564)GGT>GAT	p.G188D	SERPINA1_uc001ycw.3_RNA|SERPINA1_uc010auw.2_Missense_Mutation_p.G188D|SERPINA1_uc010aux.2_Missense_Mutation_p.G188D|SERPINA1_uc001ycy.3_Missense_Mutation_p.G188D|SERPINA1_uc010auy.2_Missense_Mutation_p.G188D|SERPINA1_uc001ycz.3_Missense_Mutation_p.G188D|SERPINA1_uc010auz.2_Missense_Mutation_p.G188D|SERPINA1_uc010ava.2_Missense_Mutation_p.G188D|SERPINA1_uc001ydb.3_Missense_Mutation_p.G188D|SERPINA1_uc010avb.2_Missense_Mutation_p.G188D|SERPINA1_uc001ydc.3_Missense_Mutation_p.G188D|SERPINA1_uc001yda.1_Missense_Mutation_p.G188D	NM_000295	NP_000286	P01009	A1AT_HUMAN	serine proteinase inhibitor, clade A, member 1	188					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			skin(1)	1		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	CCCTTGAGTACCCTTCTCCAC	0.438			NA							Alpha-1-Antitrypsin_Deficiency				17	123					0	0	0.007413	0	0
SERPINA12	145264	broad.mit.edu	37	14	94964298	94964298	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:94964298G>A	uc001ydj.2	-	3	1233	c.437C>T	c.(436-438)CCA>CTA	p.P146L		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	146					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		CTTACGCTGTGGCTGCAGCCT	0.478			NA											21	112					0	0	0.010504	0	0
TCL6	27004	broad.mit.edu	37	14	96137667	96137667	+	Splice_Site	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr14:96137667G>A	uc001yeq.2	+	7	1864	c.395_splice	c.e7-1	p.E132_splice	TCL6_uc001yep.1_Intron|TCL6_uc001yes.2_Splice_Site|TCL6_uc001yet.1_Splice_Site_p.E74_splice|TCL6_uc001yeu.2_Splice_Site|TCL6_uc001yev.2_Splice_Site|TCL1B_uc001yew.2_Splice_Site|TCL1B_uc001yex.2_Splice_Site|TCL1B_uc010avj.2_Splice_Site|TCL6_uc010avk.1_Splice_Site	NM_020554	NP_065579			SubName: Full=T-cell leukemia/lymphoma 6 ORF163;												0		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		caccctgctagaaaggacgtg	0			NA	T	TRA@	T-ALL								3	28					0	0	0.004672	0	0
CYFIP1	23191	broad.mit.edu	37	15	22935909	22935909	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr15:22935909A>G	uc001yus.2	+	9	949	c.845A>G	c.(844-846)TAT>TGT	p.Y282C	CYFIP1_uc001yut.2_Missense_Mutation_p.Y282C|CYFIP1_uc010aya.1_Missense_Mutation_p.Y310C	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	282					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		AGTAACATCTATAAGTTGGAT	0.368			NA											11	72					0	0	0.00245	0	0
NIPA1	123606	broad.mit.edu	37	15	23052736	23052736	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr15:23052736G>A	uc001yvc.2	-	4	362	c.337C>T	c.(337-339)CTC>TTC	p.L113F	NIPA1_uc001yvd.2_5'UTR|NIPA1_uc001yve.2_Missense_Mutation_p.L38F	NM_144599	NP_653200	Q7RTP0	NIPA1_HUMAN	non-imprinted in Prader-Willi/Angelman syndrome	113	Cytoplasmic (Potential).				cell death	early endosome|integral to membrane|plasma membrane					0		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;4.18e-06)|Epithelial(43;3.97e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00165)		TCCTTCAGGAGATAGGAAGCT	0.413			NA											6	76					0	0	0.001168	0	0
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42139582	42139582	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr15:42139582C>A	uc010bco.2	+	19	2096	c.1995C>A	c.(1993-1995)TTC>TTA	p.F665L	JMJD7-PLA2G4B_uc001zoo.3_Missense_Mutation_p.F896L|JMJD7-PLA2G4B_uc010bcn.2_Intron|JMJD7-PLA2G4B_uc001zoq.3_Missense_Mutation_p.F366L	NM_001114633	NP_001108105	P0C869	PA24B_HUMAN	phospholipase A2, group IVB	665	PLA2c.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1						GGATCCCGTTCCCACCCATCT	0.682			NA											10	104					2.17888e-05	2.74029e-05	0.006214	1	0
TRPM7	54822	broad.mit.edu	37	15	50916388	50916388	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr15:50916388G>A	uc001zyt.3	-	12	1679	c.1415C>T	c.(1414-1416)CCG>CTG	p.P472L	TRPM7_uc010bew.1_Missense_Mutation_p.P472L|TRPM7_uc001zyu.2_Missense_Mutation_p.P30L	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	472	Cytoplasmic (Potential).				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TTCCAGTCTCGGAATGGTAAG	0.323			NA											4	46					0	0	0.009096	0	0
ANXA2	302	broad.mit.edu	37	15	60649389	60649389	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr15:60649389C>A	uc002agn.2	-	7	564	c.404G>T	c.(403-405)AGA>ATA	p.R135I	ANXA2_uc002agk.2_Missense_Mutation_p.R135I|ANXA2_uc002agl.2_Missense_Mutation_p.R135I|ANXA2_uc002agm.2_Missense_Mutation_p.R153I|ANXA2_uc010uhd.1_RNA|ANXA2_uc010bgj.2_Missense_Mutation_p.R135I	NM_001136015	NP_001129487	P07355	ANXA2_HUMAN	annexin A2 isoform 2	135	Annexin 2.				angiogenesis|positive regulation of vesicle fusion|skeletal system development	basement membrane|melanosome|midbody|soluble fraction	calcium ion binding|calcium-dependent phospholipid binding|cytoskeletal protein binding|phospholipase inhibitor activity			ovary(1)	1					Alteplase(DB00009)|Anistreplase(DB00029)|Tenecteplase(DB00031)	CTGGTTGGTTCTGGAGCAGAT	0.488			NA											6	54					1.26484e-09	1.86932e-09	0.00308	1	0
VPS13C	54832	broad.mit.edu	37	15	62202476	62202476	+	Nonsense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr15:62202476G>C	uc002agz.2	-	64	8818	c.8744C>G	c.(8743-8745)TCA>TGA	p.S2915*	VPS13C_uc002aha.2_Nonsense_Mutation_p.S2872*|VPS13C_uc002ahb.1_Nonsense_Mutation_p.S2915*|VPS13C_uc002ahc.1_Nonsense_Mutation_p.S2872*|VPS13C_uc002ahd.1_Nonsense_Mutation_p.S292*	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	2915					protein localization					ovary(2)	2						AAGTTTGCCTGACAAACTTTC	0.348			NA											5	32					0	0	0.001984	0	0
SPESP1	246777	broad.mit.edu	37	15	69238346	69238346	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr15:69238346C>A	uc002arn.1	+	2	601	c.473C>A	c.(472-474)GCA>GAA	p.A158E	NOX5_uc002arp.1_Intron|NOX5_uc002arq.1_Intron|NOX5_uc010bid.1_Intron|NOX5_uc002aro.2_Intron	NM_145658	NP_663633	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1 precursor	158					multicellular organismal development	acrosomal vesicle					0						CAAACTGAGGCACCAAGAATG	0.433			NA											7	80					8.12818e-05	9.7994e-05	0.001984	1	0
GOLGA6B	55889	broad.mit.edu	37	15	72953689	72953689	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr15:72953689C>A	uc010uks.1	+	8	690	c.649C>A	c.(649-651)CAG>AAG	p.Q217K		NM_018652	NP_061122	A6NDN3	GOG6B_HUMAN	golgi autoantigen, golgin subfamily a, 6B	217	Potential.										0						ACACGTGACACAGGTGAGGCT	0.597			NA											4	102					5.9392e-07	8.11361e-07	0.001168	1	0
CSPG4	1464	broad.mit.edu	37	15	75974658	75974658	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr15:75974658G>T	uc002baw.2	-	8	5019	c.4926C>A	c.(4924-4926)GCC>GCA	p.A1642A		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	1642	Extracellular (Potential).|Cysteine-containing.|Neurite growth inhibition (By similarity).|CSPG 11.				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						AGTTCACCAGGGCCTCCCCTG	0.662			NA											5	73					1.06961e-07	1.48823e-07	0.00308	1	0
SGK269	79834	broad.mit.edu	37	15	77471964	77471964	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr15:77471964G>A	uc002bcm.2	-	3	2613	c.2305C>T	c.(2305-2307)CAG>TAG	p.Q769*	SGK269_uc002bcn.2_Nonsense_Mutation_p.Q769*	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	769					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		GCCACAATCTGAGAAAGCACT	0.522			NA											7	64					0	0	0.001984	0	0
SGK269	79834	broad.mit.edu	37	15	77472167	77472167	+	Nonsense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr15:77472167G>C	uc002bcm.2	-	3	2410	c.2102C>G	c.(2101-2103)TCA>TGA	p.S701*	SGK269_uc002bcn.2_Nonsense_Mutation_p.S701*	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	701					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		CTGAGCCACTGAGCCCCTTTT	0.448			NA											11	190					0	0	0.008291	0	0
WDR93	56964	broad.mit.edu	37	15	90258235	90258235	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr15:90258235T>A	uc002boj.2	+	6	766	c.665T>A	c.(664-666)GTG>GAG	p.V222E	WDR93_uc010bnr.2_Missense_Mutation_p.V222E	NM_020212	NP_064597	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	222					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			ovary(2)	2	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			TGGCTGGATGTGTATAAATTG	0.463			NA											3	28					0	0	0.004672	0	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr15:102515299G>A	uc002cdi.2	+	9	1943	c.523G>A	c.(523-525)GGC>AGC	p.G175S	WASH3P_uc002cdl.2_Missense_Mutation_p.G175S|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.G175S|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						TGGGGGCATCGGCAAGGCCAA	0.652			NA											5	11					0	0	0.000602	0	0
STUB1	10273	broad.mit.edu	37	16	731479	731479	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:731479G>A	uc002cit.2	+	3	811	c.400G>A	c.(400-402)GAC>AAC	p.D134N	STUB1_uc002ciu.2_Missense_Mutation_p.D62N|STUB1_uc010bqz.2_RNA|STUB1_uc002civ.2_RNA	NM_005861	NP_005852	Q9UNE7	CHIP_HUMAN	STIP1 homology and U-box containing protein 1	134					cellular response to misfolded protein|DNA repair|misfolded or incompletely synthesized protein catabolic process|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K63-linked ubiquitination|protein maturation|regulation of glucocorticoid metabolic process|ubiquitin-dependent SMAD protein catabolic process	cytoplasm|nuclear inclusion body|ubiquitin conjugating enzyme complex|ubiquitin ligase complex	Hsp70 protein binding|Hsp90 protein binding|kinase binding|misfolded protein binding|protein binding, bridging|protein homodimerization activity|SMAD binding|TPR domain binding|ubiquitin-ubiquitin ligase activity				0		Hepatocellular(780;0.00335)				CTTCGGGGACGACATCCCCAG	0.642			NA											6	21					0	0	0.001168	0	0
ANKS3	124401	broad.mit.edu	37	16	4748910	4748910	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:4748910G>C	uc002cxj.1	-	13	1737	c.1442C>G	c.(1441-1443)GCC>GGC	p.A481G	ANKS3_uc010uxr.1_Missense_Mutation_p.A4G|ANKS3_uc002cxh.1_RNA|ANKS3_uc002cxi.1_Missense_Mutation_p.A408G|ANKS3_uc002cxk.2_Missense_Mutation_p.A352G|ANKS3_uc002cxl.2_Missense_Mutation_p.A308G|ANKS3_uc010uxs.1_Missense_Mutation_p.A408G	NM_133450	NP_597707	Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain	481	SAM.										0						GCGGGCAATGGCGGACGTCAT	0.652			NA											5	45					0	0	0.000602	0	0
CLEC16A	23274	broad.mit.edu	37	16	11071113	11071113	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:11071113G>T	uc002dao.2	+	8	990	c.760G>T	c.(760-762)GTG>TTG	p.V254L	CLEC16A_uc002dan.3_Missense_Mutation_p.V252L	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	254										ovary(1)|central_nervous_system(1)	2						GAGTGATCTGGTGGCAGAGCA	0.527			NA											13	58					0.00136819	0.00153476	0.001368	1	0
GPR139	124274	broad.mit.edu	37	16	20043061	20043061	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:20043061G>T	uc002dgu.1	-	2	1220	c.1058C>A	c.(1057-1059)CCG>CAG	p.P353Q	GPR139_uc010vaw.1_Missense_Mutation_p.P260Q	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	353	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)	2						ATGGAATCACGGGGATACTTT	0.473			NA											8	87					0.00621372	0.00673588	0.006214	1	0
POLR3E	55718	broad.mit.edu	37	16	22330212	22330212	+	Silent	SNP	C	C	T	rs58061211		TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:22330212C>T	uc002dkk.2	+	13	1087	c.931C>T	c.(931-933)CTG>TTG	p.L311L	POLR3E_uc002dkj.1_Silent_p.L311L|POLR3E_uc002dkm.2_Silent_p.L275L|POLR3E_uc010vbr.1_Silent_p.L311L|POLR3E_uc002dkl.2_Silent_p.L311L|POLR3E_uc010vbs.1_Silent_p.L275L|POLR3E_uc010vbt.1_Silent_p.L255L	NM_018119	NP_060589	Q9NVU0	RPC5_HUMAN	RNA polymerase III polypeptide E	311					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.012)		CGTGGCTGTTCTGCGGGGCAT	0.463			NA											16	72					0	0	0.008871	0	0
DCTN5	84516	broad.mit.edu	37	16	23678456	23678456	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:23678456G>T	uc002dly.1	+	6	597	c.540G>T	c.(538-540)ACG>ACT	p.T180T		NM_032486	NP_115875	Q9BTE1	DCTN5_HUMAN	dynactin 5	180						centrosome	transferase activity			upper_aerodigestive_tract(1)	1				GBM - Glioblastoma multiforme(48;0.0156)		TGCCCCTGACGCAAGTCTAGC	0.507			NA											9	46					0.000442599	0.00050913	0.006214	1	0
TNRC6A	27327	broad.mit.edu	37	16	24801038	24801038	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:24801038A>T	uc002dmm.2	+	6	1189	c.1075A>T	c.(1075-1077)AGC>TGC	p.S359C	TNRC6A_uc010bxs.2_Missense_Mutation_p.S106C|TNRC6A_uc010vcc.1_Missense_Mutation_p.S106C|TNRC6A_uc002dmn.2_Missense_Mutation_p.S106C|TNRC6A_uc002dmo.2_Missense_Mutation_p.S106C	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	359	Ser-rich.|Sufficient for interaction with EIF2C1, EIF2C3 and EIF2C4.|Sufficient for interaction with EIF2C2.|Sufficient for interaction with EIF2C2.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		GTTAAATCCAAGCACTTTGAA	0.448			NA											7	72					0	0	0.00308	0	0
AQP8	343	broad.mit.edu	37	16	25235823	25235823	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:25235823C>T	uc002doc.2	+	4	610	c.528C>T	c.(526-528)GCC>GCT	p.A176A		NM_001169	NP_001160	O94778	AQP8_HUMAN	aquaporin 8	176	Helical; (Potential).				cellular response to cAMP	integral to plasma membrane	water channel activity			upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(48;0.044)		GCATGGGTGCCATCAATGAGA	0.622			NA											12	60					0	0	0.001368	0	0
GTF3C1	2975	broad.mit.edu	37	16	27499680	27499680	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:27499680C>A	uc002dov.1	-	23	3608	c.3568G>T	c.(3568-3570)GGC>TGC	p.G1190C	GTF3C1_uc002dou.2_Missense_Mutation_p.G1190C	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1190						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						TCTTCCCAGCCAGCACAGAGC	0.562			NA											25	186					1.5548e-18	2.5714e-18	0.005443	1	0
CD19	930	broad.mit.edu	37	16	28948593	28948594	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:28948593_28948594CC>AA	uc002drs.2	+	9	1262_1263	c.1200_1201CC>AA	c.(1198-1203)GGCCCA>GGAACA	p.P401T	uc010vct.1_Intron|CD19_uc010byo.1_Missense_Mutation_p.P401T	NM_001770	NP_001761	P15391	CD19_HUMAN	CD19 antigen precursor	401	Cytoplasmic (Potential).				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			ovary(2)|central_nervous_system(1)	3						AACCCCCAGGCCCAGAAGAAGA	0.614			NA											6	12					0	0	0.004672	0	0
PRSS53	339105	broad.mit.edu	37	16	31095549	31095549	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:31095549G>A	uc002eaq.2	-	10	1533	c.1533C>T	c.(1531-1533)TTC>TTT	p.F511F	PRSS53_uc002ear.2_Silent_p.F305F	NM_001039503	NP_001034592	Q2L4Q9	PRS53_HUMAN	polyserase 3 precursor	511	Peptidase S1 2.				proteolysis	extracellular region	serine-type endopeptidase activity				0						GGAGCGCGGTGAAGACCGCCG	0.662			NA											4	17					0	0	0.009096	0	0
ITGAM	3684	broad.mit.edu	37	16	31277365	31277365	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:31277365C>A	uc002ebq.2	+	5	422	c.324C>A	c.(322-324)ACC>ACA	p.T108T	ITGAM_uc002ebr.2_Silent_p.T108T	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	108	FG-GAP 2.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						GTGGTCCCACCGTGCACCAGA	0.622			NA											15	36					3.32936e-07	4.57597e-07	0.006122	1	0
CSDAP1	440359	broad.mit.edu	37	16	31580426	31580426	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:31580426C>A	uc010vfr.1	-	1	420	c.393G>T	c.(391-393)CTG>CTT	p.L131L		NR_027011				SubName: Full=CSDA protein variant; Flags: Fragment;												0						CTACACTGCGCAGATATTTCT	0.438			NA											13	60					6.31663e-08	8.84328e-08	0.003163	1	0
NOD2	64127	broad.mit.edu	37	16	50745464	50745464	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:50745464C>T	uc002egm.1	+	4	1747	c.1642C>T	c.(1642-1644)CTG>TTG	p.L548L	NOD2_uc010cbk.1_Silent_p.L521L|NOD2_uc002egl.1_Silent_p.L326L|NOD2_uc010cbl.1_Silent_p.L326L|NOD2_uc010cbm.1_Silent_p.L326L|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_RNA|NOD2_uc010cbp.1_5'Flank|NOD2_uc010cbq.1_5'Flank|NOD2_uc010cbr.1_5'Flank	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	548	NACHT.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				CCCCACCCTCCTGCACCTGGG	0.627			NA											6	47					0	0	0.00308	0	0
RBL2	5934	broad.mit.edu	37	16	53487410	53487410	+	Silent	SNP	C	C	T	rs140105334		TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:53487410C>T	uc002ehi.3	+	6	931	c.813C>T	c.(811-813)GAC>GAT	p.D271D	RBL2_uc010vgv.1_Silent_p.D197D|RBL2_uc002ehj.2_5'UTR|RBL2_uc010vgw.1_Silent_p.D55D	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	271					cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						CTTCCTCTGACCCCCCTTGTA	0.383			NA											21	186					0	0	0.001882	0	0
OGFOD1	55239	broad.mit.edu	37	16	56504618	56504618	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:56504618G>C	uc002ejb.2	+	10	1301	c.1200G>C	c.(1198-1200)GAG>GAC	p.E400D	OGFOD1_uc002ejc.2_Missense_Mutation_p.E260D	NM_018233	NP_060703	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase	400							iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)	1					Vitamin C(DB00126)	CTGAGCCAGAGAATAATCAGA	0.453			NA											3	31					0	0	0.009096	0	0
CNGB1	1258	broad.mit.edu	37	16	57994775	57994775	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:57994775C>T	uc002emt.2	-	8	568	c.503G>A	c.(502-504)AGA>AAA	p.R168K	CNGB1_uc010cdh.2_Missense_Mutation_p.R168K|CNGB1_uc002emu.2_Missense_Mutation_p.R168K	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	168					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						AGGAAGCACTCTTTCCAGATT	0.627	Colon(156;1293 1853 16336 28962 38659)		NA											6	37					0	0	0.001984	0	0
CDH11	1009	broad.mit.edu	37	16	64981815	64981815	+	Silent	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:64981815T>C	uc002eoi.2	-	13	2516	c.2082A>G	c.(2080-2082)AAA>AAG	p.K694K	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_3'UTR|CDH11_uc010vin.1_Silent_p.K568K	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	694	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		GTTTGATGTCTTTGCGGGGGA	0.498			NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			21	126					0	0	0.001882	0	0
ESRP2	80004	broad.mit.edu	37	16	68268006	68268006	+	Nonsense_Mutation	SNP	G	G	C	rs12597504		TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:68268006G>C	uc010cfa.1	-	3	520	c.332C>G	c.(331-333)TCA>TGA	p.S111*	ESRP2_uc002evp.1_5'Flank|ESRP2_uc002evq.1_Nonsense_Mutation_p.S111*	NM_024939	NP_079215	Q9H6T0	ESRP2_HUMAN	RNA binding motif protein 35B	111					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding|nucleotide binding			ovary(1)	1						CACCAGCTGTGAGAACTGGGG	0.607			NA											3	15					0	0	0.004672	0	0
NFAT5	10725	broad.mit.edu	37	16	69724898	69724898	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:69724898G>A	uc002exm.1	+	11	2984	c.1776G>A	c.(1774-1776)CTG>CTA	p.L592L	NFAT5_uc002exi.2_Silent_p.L516L|NFAT5_uc002exj.1_Silent_p.L516L|NFAT5_uc002exk.1_Silent_p.L516L|NFAT5_uc002exl.1_Silent_p.L610L|NFAT5_uc002exn.1_Silent_p.L609L|NFAT5_uc002exo.1_5'Flank	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	592					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						CTAATGCCCTGATGACTCCAC	0.328			NA											11	86					0	0	0.000978	0	0
PHLPP2	23035	broad.mit.edu	37	16	71701199	71701199	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:71701199C>A	uc002fax.2	-	11	1672	c.1666G>T	c.(1666-1668)GGA>TGA	p.G556*	PHLPP2_uc002fav.2_RNA|PHLPP2_uc010cgf.2_Nonsense_Mutation_p.G556*	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	556	LRR 14.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						TGATTGTGTCCCAGCATCAGT	0.453			NA											5	56					0.00116845	0.00131559	0.001168	1	0
CNTNAP4	85445	broad.mit.edu	37	16	76350405	76350405	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:76350405C>A	uc002feu.1	+	4	566	c.181C>A	c.(181-183)CTG>ATG	p.L61M	CNTNAP4_uc002fev.1_Translation_Start_Site|CNTNAP4_uc010chb.1_Missense_Mutation_p.L36M|CNTNAP4_uc002fex.1_Missense_Mutation_p.L64M|CNTNAP4_uc002few.2_Missense_Mutation_p.L36M	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	61	Extracellular (Potential).|F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						ATTTGCAAGGCTGAATAGAAG	0.448			NA											8	28					0.00448238	0.00490617	0.004482	1	0
CNTNAP4	85445	broad.mit.edu	37	16	76569454	76569454	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:76569454C>T	uc002feu.1	+	20	3153	c.2768C>T	c.(2767-2769)ACC>ATC	p.T923I	CNTNAP4_uc002fev.1_Missense_Mutation_p.T787I|CNTNAP4_uc010chb.1_Missense_Mutation_p.T850I|CNTNAP4_uc002fex.1_Missense_Mutation_p.T926I	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	923	Extracellular (Potential).|Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						GGAACGGCCACCAGACAGAGA	0.478			NA											8	41					0	0	0.006214	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76569461	76569461	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:76569461G>T	uc002feu.1	+	20	3160	c.2775G>T	c.(2773-2775)CAG>CAT	p.Q925H	CNTNAP4_uc002fev.1_Missense_Mutation_p.Q789H|CNTNAP4_uc010chb.1_Missense_Mutation_p.Q852H|CNTNAP4_uc002fex.1_Missense_Mutation_p.Q928H	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	925	Extracellular (Potential).|Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						CCACCAGACAGAGAGGCTTTC	0.478			NA											8	48					0.000274275	0.000318342	0.004482	1	0
CENPN	55839	broad.mit.edu	37	16	81053854	81053854	+	Silent	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr16:81053854G>C	uc002ffx.2	+	6	1294	c.504G>C	c.(502-504)CTG>CTC	p.L168L	CENPN_uc002ffw.3_Silent_p.L168L|CENPN_uc010vnl.1_Silent_p.L168L|CENPN_uc010vnm.1_Silent_p.L148L|CENPN_uc002ffy.3_Silent_p.L168L	NM_001100624	NP_001094094	Q96H22	CENPN_HUMAN	centromere protein N isoform 2	168					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0						CCTCCATGCTGAGGCGCAATA	0.428			NA											3	30					0	0	0.009096	0	0
PLD2	5338	broad.mit.edu	37	17	4712637	4712637	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:4712637C>G	uc002fzc.2	+	6	635	c.534C>G	c.(532-534)TTC>TTG	p.F178L	PLD2_uc010vsj.1_Missense_Mutation_p.F35L|PLD2_uc002fzd.2_Missense_Mutation_p.F178L	NM_002663	NP_002654	O14939	PLD2_HUMAN	phospholipase D2	178	PX.				cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5					Choline(DB00122)	CCATGTCTTTCTATCGCAACT	0.537			NA											16	75					0	0	0.007413	0	0
ZNF594	84622	broad.mit.edu	37	17	5085607	5085607	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:5085607C>A	uc010cla.1	-	2	2101	c.1945G>T	c.(1945-1947)GAG>TAG	p.E649*		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	649					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						TAGGGTTTCTCTCCAGTATGA	0.413			NA											21	101					4.96729e-08	6.97584e-08	0.008871	1	0
DNAH2	146754	broad.mit.edu	37	17	7736529	7736529	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:7736529G>A	uc002giu.1	+	84	13133	c.13119G>A	c.(13117-13119)AAG>AAA	p.K4373K		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	4373					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GCCGCAAGAAGAGCGCCAAGG	0.617			NA											4	26					0	0	0.009096	0	0
CHD3	1107	broad.mit.edu	37	17	7797526	7797526	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:7797526G>T	uc002gje.2	+	7	1168	c.1018G>T	c.(1018-1020)GGC>TGC	p.G340C	CHD3_uc002gjd.2_Missense_Mutation_p.G399C|CHD3_uc002gjf.2_Missense_Mutation_p.G340C|CHD3_uc002gjg.1_Missense_Mutation_p.G168C	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	340					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				CCGGCCTGATGGCCCTGTCCG	0.567			NA											7	19					8.12818e-05	9.7994e-05	0.001984	1	0
MYH8	4626	broad.mit.edu	37	17	10304093	10304093	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:10304093G>A	uc002gmm.2	-	27	3444	c.3349C>T	c.(3349-3351)CGC>TGC	p.R1117C	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1117	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TCCTCAATGCGGGCCTGGGAA	0.512			NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				13	39					0	0	0.001855	0	0
RPL23A	6147	broad.mit.edu	37	17	27050632	27050632	+	Missense_Mutation	SNP	T	T	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:27050632T>G	uc002hci.2	+	4	454	c.430T>G	c.(430-432)TAC>GAC	p.Y144D	RPL23A_uc002hck.1_RNA|SNORD4B_uc002hcn.1_5'Flank	NM_000984	NP_000975	P62750	RL23A_HUMAN	ribosomal protein L23a	144					cell proliferation|endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	nucleotide binding|protein binding|rRNA binding|structural constituent of ribosome			ovary(1)	1	Lung NSC(42;0.00431)					GGCTCCTGATTACGATGCTTT	0.512			NA											16	192					0	0	0.007413	0	0
CPD	1362	broad.mit.edu	37	17	28773009	28773009	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:28773009G>A	uc002hfb.1	+	12	2859	c.2844G>A	c.(2842-2844)ATG>ATA	p.M948I	CPD_uc010wbo.1_Missense_Mutation_p.M701I|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	948	Extracellular (Potential).|Carboxypeptidase-like 3.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						GACTTGTAATGAACTATCCAC	0.363			NA											14	90					0	0	0.003163	0	0
ATAD5	79915	broad.mit.edu	37	17	29206476	29206476	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:29206476G>C	uc002hfs.1	+	18	4394	c.4048G>C	c.(4048-4050)GAA>CAA	p.E1350Q		NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1350					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TGGCTGCTTTGAAGAAATCAA	0.289			NA											3	74					0	0	0.004672	0	0
EVI2B	2124	broad.mit.edu	37	17	29632338	29632338	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:29632338G>A	uc002hgk.2	-	2	445	c.290C>T	c.(289-291)TCT>TTT	p.S97F	NF1_uc002hgg.2_Intron|NF1_uc002hgh.2_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.2_Intron|EVI2B_uc010csq.2_Missense_Mutation_p.S112F	NM_006495	NP_006486	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B precursor	97	Extracellular (Potential).					cytoplasm|integral to plasma membrane				ovary(2)	2		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		TTGTCCAGCAGAAGTATGTGC	0.478			NA											33	155					0	0	0.003271	0	0
LRRC37B	114659	broad.mit.edu	37	17	30348281	30348281	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:30348281C>G	uc002hgu.2	+	1	127	c.116C>G	c.(115-117)TCT>TGT	p.S39C	LRRC37B_uc010wbx.1_Intron|LRRC37B_uc010csu.2_Missense_Mutation_p.S39C	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	39	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				CAGCTGACCTCTAACCCCCTG	0.627			NA											23	75					0	0	0.004656	0	0
TMEM132E	124842	broad.mit.edu	37	17	32965202	32965202	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:32965202C>A	uc002hif.2	+	10	3234	c.2906C>A	c.(2905-2907)GCA>GAA	p.A969E		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	969	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CGGCCCACTGCACCCCCGGAC	0.677			NA									OREG0024325	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	12					0.00024832	0.000291212	0.009096	1	0
SLFN5	162394	broad.mit.edu	37	17	33591742	33591742	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:33591742A>T	uc002hjf.3	+	4	1796	c.1679A>T	c.(1678-1680)CAG>CTG	p.Q560L	SLFN5_uc010wcg.1_Intron	NM_144975	NP_659412	Q08AF3	SLFN5_HUMAN	schlafen family member 5	560					cell differentiation		ATP binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		ACAAATAAACAGTATGAGTTG	0.448			NA											31	223					0	0	0.009535	0	0
SLFN11	91607	broad.mit.edu	37	17	33679766	33679766	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:33679766C>A	uc010ctp.2	-	7	2757	c.2315G>T	c.(2314-2316)GGT>GTT	p.G772V	SLFN11_uc010ctq.2_Missense_Mutation_p.G772V|SLFN11_uc002hjh.3_Missense_Mutation_p.G772V|SLFN11_uc002hjg.3_Missense_Mutation_p.G772V|SLFN11_uc010ctr.2_Missense_Mutation_p.G772V	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	772						nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TCCCTGAACACCCTGGGACCA	0.438			NA											9	58					1.12685e-05	1.45156e-05	0.004482	1	0
PIGW	284098	broad.mit.edu	37	17	34894341	34894341	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:34894341T>C	uc002hmy.1	+	2	1434	c.1391T>C	c.(1390-1392)CTG>CCG	p.L464P	PIGW_uc002hmz.1_Missense_Mutation_p.L464P	NM_178517	NP_848612	Q7Z7B1	PIGW_HUMAN	phosphatidylinositol glycan, class W	464	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	O-acyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CTGATCAACCTGATGGTAGAT	0.353			NA											3	91					0	0	0.004672	0	0
GGNBP2	79893	broad.mit.edu	37	17	34934557	34934557	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:34934557C>T	uc002hnb.2	+	7	1035	c.786C>T	c.(784-786)TGC>TGT	p.C262C	GGNBP2_uc002hna.2_Silent_p.C262C|GGNBP2_uc002hnc.1_Silent_p.C91C	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	262					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		TACATGTTTGCTGTGAAACAG	0.463			NA											22	170					0	0	0.00632	0	0
ACACA	31	broad.mit.edu	37	17	35506835	35506835	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:35506835C>A	uc002hnm.2	-	45	5712	c.5521G>T	c.(5521-5523)GTT>TTT	p.V1841F	ACACA_uc002hnk.2_Missense_Mutation_p.V1763F|ACACA_uc002hnl.2_Missense_Mutation_p.V1783F|ACACA_uc002hnn.2_Missense_Mutation_p.V1841F|ACACA_uc002hno.2_Missense_Mutation_p.V1878F|ACACA_uc010cuy.2_Missense_Mutation_p.V486F|ACACA_uc010wdc.1_5'UTR	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1841	Carboxyltransferase.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GAATTCTCAACCTGGATGGTT	0.423	Colon(23;82 258 739 2117 10493 24037 27661 34815 35438 36249)		NA											11	85					0.00010058	0.000120616	0.001368	1	0
PLXDC1	57125	broad.mit.edu	37	17	37226111	37226111	+	Missense_Mutation	SNP	C	C	T	rs151120531	byFrequency	TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:37226111C>T	uc002hrg.2	-	13	1593	c.1381G>A	c.(1381-1383)GAG>AAG	p.E461K	uc002hre.1_Intron|uc002hrf.1_Intron|PLXDC1_uc010cvr.1_Missense_Mutation_p.E157K|PLXDC1_uc002hrh.2_RNA|PLXDC1_uc002hri.2_RNA|PLXDC1_uc002hrj.1_RNA|PLXDC1_uc002hrk.1_RNA	NM_020405	NP_065138	Q8IUK5	PXDC1_HUMAN	plexin domain containing 1 precursor	461	Cytoplasmic (Potential).				angiogenesis	cytoplasm|extracellular region|integral to membrane|tight junction				ovary(1)|kidney(1)|skin(1)	3						ACACGGACCTCGATGAAGAAG	0.622			NA									OREG0024368	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	34					0	0	0.001168	0	0
WNK4	65266	broad.mit.edu	37	17	40948569	40948569	+	Silent	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:40948569G>C	uc002ibj.2	+	18	3723	c.3702G>C	c.(3700-3702)GTG>GTC	p.V1234V	WNK4_uc010wgx.1_Silent_p.V898V|CCDC56_uc010wgz.1_Intron|CNTD1_uc002ibm.3_5'Flank|CNTD1_uc010wha.1_5'Flank	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	1234					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		GCAAGGGGGTGACATTCGCCG	0.647	Esophageal Squamous(6;201 374 4964 23855 42828)		NA											10	56					0	0	0.006214	0	0
GPATCH8	23131	broad.mit.edu	37	17	42475265	42475265	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:42475265G>C	uc002igw.1	-	8	4244	c.4180C>G	c.(4180-4182)CAC>GAC	p.H1394D	GPATCH8_uc002igv.1_Missense_Mutation_p.H1316D|GPATCH8_uc010wiz.1_Missense_Mutation_p.H1316D	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1394						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GGGTGAGGGTGAATGCCGATG	0.572			NA											8	27					0	0	0.006214	0	0
GPATCH8	23131	broad.mit.edu	37	17	42475368	42475368	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:42475368G>C	uc002igw.1	-	8	4141	c.4077C>G	c.(4075-4077)ATC>ATG	p.I1359M	GPATCH8_uc002igv.1_Missense_Mutation_p.I1281M|GPATCH8_uc010wiz.1_Missense_Mutation_p.I1281M	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1359						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GCTGAATGTGGATGGGTTGCA	0.597			NA											6	36					0	0	0.001168	0	0
OR4D2	124538	broad.mit.edu	37	17	56247937	56247937	+	Silent	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:56247937T>A	uc010wnp.1	+	1	921	c.921T>A	c.(919-921)GTT>GTA	p.V307V		NM_001004707	NP_001004707	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D,	307	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						ACCGGCTGGTTTGAGAGTGAC	0.498			NA											12	76					0	0	0.001855	0	0
BZRAP1	9256	broad.mit.edu	37	17	56393883	56393883	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:56393883C>A	uc002ivx.3	-	15	2762	c.1891G>T	c.(1891-1893)GTA>TTA	p.V631L	BZRAP1_uc010dcs.2_Missense_Mutation_p.V571L|BZRAP1_uc010wnt.1_Missense_Mutation_p.V631L	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	631						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGCTCCTCTACCTCACTGGCT	0.627			NA											8	32					0.00307968	0.00339969	0.00308	1	0
APPBP2	10513	broad.mit.edu	37	17	58524943	58524943	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:58524943C>T	uc002iys.1	-	13	2045	c.1757G>A	c.(1756-1758)TGA>TAA	p.*586*	APPBP2_uc010ddl.1_Silent_p.*515*	NM_006380	NP_006371	Q92624	APBP2_HUMAN	amyloid beta precursor protein-binding protein	586					intracellular protein transport	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|nucleus	microtubule motor activity|protein binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.67e-13)|all cancers(12;1.44e-11)|Colorectal(3;0.01)			GGTCCTCCCTCAGCAGCTCGG	0.493			NA											31	179					0	0	0.002096	0	0
APPBP2	10513	broad.mit.edu	37	17	58524966	58524966	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:58524966C>G	uc002iys.1	-	13	2022	c.1734G>C	c.(1732-1734)CAG>CAC	p.Q578H	APPBP2_uc010ddl.1_Missense_Mutation_p.Q507H	NM_006380	NP_006371	Q92624	APBP2_HUMAN	amyloid beta precursor protein-binding protein	578					intracellular protein transport	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|nucleus	microtubule motor activity|protein binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.67e-13)|all cancers(12;1.44e-11)|Colorectal(3;0.01)			CCTCGACATTCTGAGAAATCA	0.488			NA											30	257					0	0	0.009535	0	0
CCDC46	201134	broad.mit.edu	37	17	63898446	63898446	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:63898446C>A	uc002jfl.2	-	20	2206	c.1987G>T	c.(1987-1989)GAG>TAG	p.E663*	CCDC46_uc010deo.2_Nonsense_Mutation_p.E405*|CCDC46_uc002jfm.2_Nonsense_Mutation_p.E663*|CCDC46_uc010dep.2_Nonsense_Mutation_p.E621*	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	coiled-coil domain containing 46 isoform a	663	Potential.					centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)			AGCTTCAGCTCTACTATCTGA	0.433			NA											7	37					0.00307968	0.00339969	0.00308	1	0
ABCA10	10349	broad.mit.edu	37	17	67148553	67148553	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:67148553C>A	uc010dfa.1	-	36	5085	c.4206G>T	c.(4204-4206)GAG>GAT	p.E1402D	ABCA10_uc002jhz.2_5'Flank|ABCA10_uc010wqs.1_Missense_Mutation_p.E394D|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1402	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					CAGCCTCAGCCTCTGACATGT	0.488			NA											9	50					0.00621372	0.00673588	0.006214	1	0
FAM104A	84923	broad.mit.edu	37	17	71223366	71223366	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:71223366G>T	uc002jji.3	-	2	347	c.259C>A	c.(259-261)CTT>ATT	p.L87I	FAM104A_uc002jjj.3_Missense_Mutation_p.L87I	NM_032837	NP_116226	Q969W3	F104A_HUMAN	hypothetical protein LOC84923 isoform 2	87											0			LUSC - Lung squamous cell carcinoma(166;0.197)			TGGGGGGGAAGATGGTTGTCT	0.428			NA											14	116					2.31682e-05	2.90165e-05	0.003163	1	0
QRICH2	84074	broad.mit.edu	37	17	74286109	74286109	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:74286109C>G	uc002jrd.1	-	5	3444	c.3264G>C	c.(3262-3264)AAG>AAC	p.K1088N	QRICH2_uc010wsz.1_Missense_Mutation_p.K1014N|QRICH2_uc010dgw.1_5'UTR	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1088	Potential.						protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						TGGCTAGCGTCTTTACGGTCT	0.373			NA											30	166					0	0	0.003755	0	0
CCDC40	55036	broad.mit.edu	37	17	78022479	78022479	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:78022479G>T	uc010dht.2	+	5	801	c.774G>T	c.(772-774)ATG>ATT	p.M258I	CCDC40_uc010wub.1_Missense_Mutation_p.M258I|CCDC40_uc002jxm.3_Missense_Mutation_p.M41I	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	258					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGGGGGCCATGGCAGAGAGAG	0.642			NA											6	40					0.000157383	0.00018675	0.00308	1	0
SIRT7	51547	broad.mit.edu	37	17	79872368	79872369	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr17:79872368_79872369CC>AA	uc002kcj.1	-	7	650_651	c.617_618GG>TT	c.(616-618)CGG>CTT	p.R206L	SIRT7_uc002kck.1_Missense_Mutation_p.R57L|SIRT7_uc002kcl.1_Missense_Mutation_p.R124L	NM_016538	NP_057622	Q9NRC8	SIRT7_HUMAN	sirtuin 7	206	Deacetylase sirtuin-type.				chromatin silencing|positive regulation of transcription on exit from mitosis|protein deacetylation|rRNA transcription	cytoplasm|nucleolus organizer region	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ binding|protein binding|zinc ion binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			CATCGAACACCCGCACGTACTC	0.634			NA											6	56					0	0	0.004672	0	0
CLUL1	27098	broad.mit.edu	37	18	627251	627251	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr18:627251C>T	uc002kkp.2	+	5	723	c.578C>T	c.(577-579)TCT>TTT	p.S193F	CLUL1_uc010wys.1_Missense_Mutation_p.S245F|CLUL1_uc002kkq.2_Missense_Mutation_p.S193F	NM_014410	NP_055225	Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal) precursor	193					cell death	extracellular region				ovary(2)	2						GATGTGAATTCTCTCTTTAAC	0.408			NA											44	168					0	0	0.00361	0	0
KIAA0802	23255	broad.mit.edu	37	18	8785985	8785985	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr18:8785985G>T	uc002knr.2	+	7	1925	c.1783G>T	c.(1783-1785)GAG>TAG	p.E595*	KIAA0802_uc002knq.2_Nonsense_Mutation_p.E595*|KIAA0802_uc010dkw.1_Nonsense_Mutation_p.E433*	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	946											0						CCGAGGGGACGAGCGGGAGAG	0.642			NA											8	17					0.000274275	0.000318342	0.004482	1	0
HRH4	59340	broad.mit.edu	37	18	22057268	22057269	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr18:22057268_22057269GG>TT	uc002kvi.2	+	3	1015_1016	c.915_916GG>TT	c.(913-918)CTGGCC>CTTTCC	p.A306S	HRH4_uc010xbd.1_3'UTR|HRH4_uc010dlx.2_Missense_Mutation_p.A218S	NM_021624	NP_067637	Q9H3N8	HRH4_HUMAN	histamine H4 receptor isoform 1	306	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	histamine receptor activity			ovary(2)	2	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	CCAAGTCACTGGCCATTCTCTT	0.436			NA											66	199					0	0	0.004672	0	0
FHOD3	80206	broad.mit.edu	37	18	34335151	34335151	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr18:34335151C>G	uc002kzt.1	+	21	3823	c.3726C>G	c.(3724-3726)TTC>TTG	p.F1242L	FHOD3_uc002kzs.1_Missense_Mutation_p.F1259L|FHOD3_uc010dmz.1_Missense_Mutation_p.F974L|FHOD3_uc010dnb.1_Missense_Mutation_p.F238L	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	1242	FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				TAAACAAATTCTGCAGGATTA	0.408			NA											11	21					0	0	0.001368	0	0
C18orf10	25941	broad.mit.edu	37	18	34378463	34378463	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr18:34378463C>A	uc002kzw.1	-	6	1034	c.606G>T	c.(604-606)CTG>CTT	p.L202L	C18orf10_uc002kzv.1_Silent_p.L202L|C18orf10_uc010xci.1_Silent_p.L167L|C18orf10_uc002kzx.1_Silent_p.L159L|C18orf10_uc002kzy.3_Silent_p.L202L	NM_015476	NP_056291	Q68CL5	TPGS2_HUMAN	tubulin polyglutamylase complex subunit 2	202						cytoplasm|microtubule				skin(1)	1						GCCACTGGGGCAGGCCCAGGT	0.498			NA											34	99					5.91797e-21	9.93294e-21	0.002445	1	0
WDR7	23335	broad.mit.edu	37	18	54358458	54358458	+	Silent	SNP	C	C	T	rs143311376		TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr18:54358458C>T	uc002lgk.1	+	8	940	c.729C>T	c.(727-729)GCC>GCT	p.A243A	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Silent_p.A243A	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	243										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		TGTTCGATGCCGGAGACTATT	0.403			NA											28	126					0	0	0.00632	0	0
CDH20	28316	broad.mit.edu	37	18	59221445	59221445	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr18:59221445C>A	uc010dps.1	+	11	1935	c.1923C>A	c.(1921-1923)TCC>TCA	p.S641S	CDH20_uc002lif.2_Silent_p.S635S	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	641	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				TCATTTTGTCCATGAGGCGGC	0.537			NA											21	82					2.37509e-13	3.76265e-13	0.010504	1	0
CDH7	1005	broad.mit.edu	37	18	63489352	63489352	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr18:63489352G>C	uc002ljz.2	+	5	986	c.661G>C	c.(661-663)GAG>CAG	p.E221Q	CDH7_uc002lka.2_Missense_Mutation_p.E221Q|CDH7_uc002lkb.2_Missense_Mutation_p.E221Q	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	221	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				CATGGATAGAGAGGCTAAAGA	0.398			NA											8	24					0	0	0.00308	0	0
REEP6	92840	broad.mit.edu	37	19	1495329	1495329	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:1495329G>T	uc002ltc.2	+	2	256	c.152G>T	c.(151-153)GGC>GTC	p.G51V	REEP6_uc010xgp.1_Missense_Mutation_p.G51V	NM_138393	NP_612402	Q96HR9	REEP6_HUMAN	receptor accessory protein 6	51	Helical; (Potential).					integral to membrane					0		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCTGTTCGGCTACGGAGCG	0.652			NA											13	52					2.35188e-11	3.58741e-11	0.006122	1	0
SAFB2	9667	broad.mit.edu	37	19	5592837	5592837	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:5592837C>G	uc002mcd.2	-	16	2481	c.2269G>C	c.(2269-2271)GAC>CAC	p.D757H		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	757	Arg-rich.|Interacts with SAFB1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		CGGGGAAAGTCTGCACGATAT	0.512	Ovarian(127;888 1728 23957 44128 52668)		NA											3	37					0	0	0.004672	0	0
MLLT1	4298	broad.mit.edu	37	19	6222228	6222228	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:6222228C>A	uc002mek.2	-	6	1178	c.1014G>T	c.(1012-1014)GGG>GGT	p.G338G		NM_005934	NP_005925	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	338					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			skin(1)	1						TCACCTTCTCCCCTCTGGTGC	0.647			NA	T	MLL	AL								4	24					0.00909568	0.00978951	0.009096	1	0
SH2D3A	10045	broad.mit.edu	37	19	6754663	6754663	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:6754663G>C	uc002mft.2	-	6	1255	c.1061C>G	c.(1060-1062)CCC>CGC	p.P354R	SH2D3A_uc010xjg.1_Missense_Mutation_p.P232R	NM_005490	NP_005481	Q9BRG2	SH23A_HUMAN	SH2 domain containing 3A	354					JNK cascade|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(2)	2						GTGTCCATGGGGAAGAGTGAG	0.587			NA											4	47					0	0	0.009096	0	0
EMR1	2015	broad.mit.edu	37	19	6903852	6903852	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:6903852C>T	uc002mfw.2	+	7	731	c.693C>T	c.(691-693)ATC>ATT	p.I231I	EMR1_uc010dvc.2_Silent_p.I231I|EMR1_uc010dvb.2_Silent_p.I179I|EMR1_uc010xji.1_Silent_p.I90I|EMR1_uc010xjj.1_Intron	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	231	EGF-like 5; calcium-binding (Potential).|Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					TGTGCCCCATCAATTCAACAT	0.488			NA											16	69					0	0	0.010504	0	0
MUC16	94025	broad.mit.edu	37	19	8997117	8997118	+	Splice_Site	DNP	CC	CC	AA			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:8997117_8997118CC>AA	uc002mkp.2	-	60	41282	c.41078_splice	c.e60+1	p.R13693_splice	MUC16_uc010dwi.2_Splice_Site|MUC16_uc010dwj.2_Splice_Site_p.R510_splice|MUC16_uc010xki.1_Splice_Site	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16						cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TAAGGTCTCACCTGAGCAAAGT	0.515			NA											8	54					0	0	0.004672	0	0
MUC16	94025	broad.mit.edu	37	19	9070227	9070227	+	Nonsense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:9070227G>C	uc002mkp.2	-	3	17423	c.17219C>G	c.(17218-17220)TCA>TGA	p.S5740*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5742	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGATGTGTGTGAATCAGCTGG	0.478			NA											5	79					0	0	0.001368	0	0
MUC16	94025	broad.mit.edu	37	19	9074029	9074029	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:9074029C>T	uc002mkp.2	-	3	13621	c.13417G>A	c.(13417-13419)GGG>AGG	p.G4473R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4475	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTATGTTGCCCTTGTAACGTG	0.507			NA											19	87					0	0	0.006122	0	0
OR1M1	125963	broad.mit.edu	37	19	9204347	9204347	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:9204347C>A	uc010xkj.1	+	1	427	c.427C>A	c.(427-429)CTG>ATG	p.L143M		NM_001004456	NP_001004456	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M,	143	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3						CCTCTGTCGCCTGCTGGTCGG	0.587			NA											11	77					0.000978159	0.00111244	0.000978	1	0
S1PR5	53637	broad.mit.edu	37	19	10625652	10625652	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:10625652G>A	uc002mot.1	-	2	93	c.36C>T	c.(34-36)AGC>AGT	p.S12S	S1PR5_uc002mou.1_Silent_p.S12S	NM_030760	NP_110387	Q9H228	S1PR5_HUMAN	endothelial differentiation, sphingolipid	12	Extracellular (By similarity).					integral to membrane|plasma membrane	lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|pancreas(1)	2						CGATGACCTCGCTCACCGGCG	0.716			NA											5	45					0	0	0.000602	0	0
ZNF700	90592	broad.mit.edu	37	19	12060182	12060182	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:12060182G>A	uc002msu.2	+	4	1469	c.1343G>A	c.(1342-1344)TGT>TAT	p.C448Y	ZNF700_uc010xme.1_Missense_Mutation_p.C466Y|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	448	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCCTATGAATGTAAGGAATGT	0.483			NA											5	52					0	0	0.000602	0	0
ZNF563	147837	broad.mit.edu	37	19	12429757	12429757	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:12429757C>A	uc002mtp.2	-	4	1320	c.1082G>T	c.(1081-1083)GGA>GTA	p.G361V		NM_145276	NP_660319	Q8TA94	ZN563_HUMAN	zinc finger protein 563	361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGGTTTCTCTCCAGTGTGAAT	0.423	GBM(39;623 795 5132 29510 31476)		NA											27	138					1.42536e-11	2.19641e-11	0.004656	1	0
CACNA1A	773	broad.mit.edu	37	19	13335494	13335494	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:13335494G>C	uc010dze.2	-	38	5957	c.5721C>G	c.(5719-5721)ATC>ATG	p.I1907M	CACNA1A_uc010xnd.1_Missense_Mutation_p.I612M|CACNA1A_uc002mwx.3_Missense_Mutation_p.I612M|CACNA1A_uc010dzc.2_Missense_Mutation_p.I1432M|CACNA1A_uc002mwy.3_Missense_Mutation_p.I1906M|CACNA1A_uc002mwv.3_Missense_Mutation_p.I423M	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1907	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TGGCAATCTTGATGTCCAGGG	0.592			NA											5	17					0	0	0.001168	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15579494	15579494	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:15579494G>T	uc002nbf.3	-	5	1844	c.1711C>A	c.(1711-1713)CCA>ACA	p.P571T		NM_052890	NP_443122	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2 precursor	571					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)	3						TCTGTGGCTGGCAGGGTCCTT	0.423			NA											18	93					4.96729e-08	6.97584e-08	0.008871	1	0
CRLF1	9244	broad.mit.edu	37	19	18709709	18709709	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:18709709G>A	uc010ebt.1	-	3	594	c.400C>T	c.(400-402)CCC>TCC	p.P134S		NM_004750	NP_004741	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1 precursor	134	Fibronectin type-III 1.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(1)	1						TTCTCTGGGGGCACTGGGAGA	0.647			NA											9	77					0	0	0.008291	0	0
COMP	1311	broad.mit.edu	37	19	18897083	18897083	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:18897083A>T	uc002nke.2	-	12	1309	c.1273T>A	c.(1273-1275)TTT>ATT	p.F425I	COMP_uc002nkd.2_Missense_Mutation_p.F392I|COMP_uc010xqj.1_Missense_Mutation_p.F372I	NM_000095	NP_000086	P49747	COMP_HUMAN	cartilage oligomeric matrix protein precursor	425	TSP type-3 6.				anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding				0						TCTCCCACAAAGTCGTGGTCC	0.587			NA											6	40					0	0	0.001984	0	0
ZNF429	353088	broad.mit.edu	37	19	21720247	21720247	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:21720247G>T	uc002nqd.1	+	4	1529	c.1392G>T	c.(1390-1392)CGG>CGT	p.R464R	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	464	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CTTTTAACCGGTCCTCACACC	0.388			NA											4	30					0.00909568	0.00978951	0.009096	1	0
TSHZ3	57616	broad.mit.edu	37	19	31769101	31769101	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:31769101G>T	uc002nsy.3	-	2	1663	c.1598C>A	c.(1597-1599)GCA>GAA	p.A533E		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	533					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CTTGTTGATTGCGGATGTCAC	0.507			NA											28	139					8.58068e-18	1.40879e-17	0.007291	1	0
ZNF461	92283	broad.mit.edu	37	19	37130807	37130807	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:37130807C>A	uc002oem.2	-	6	668	c.440G>T	c.(439-441)GGC>GTC	p.G147V	ZNF461_uc002oen.2_Missense_Mutation_p.G116V|ZNF461_uc010xtj.1_Missense_Mutation_p.G124V	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			ATGACAGTTGCCTTCCCAGAT	0.368			NA											39	232					1.97e-11	3.02022e-11	0.002522	1	0
ZNF790	388536	broad.mit.edu	37	19	37309614	37309614	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:37309614G>C	uc002oew.2	-	5	1751	c.1632C>G	c.(1630-1632)ATC>ATG	p.I544M	uc002oev.1_Intron	NM_206894	NP_996777	Q6PG37	ZN790_HUMAN	zinc finger protein 790	544	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GTGAACCCCAGATAAAAGATT	0.393			NA											21	124					0	0	0.002299	0	0
RYR1	6261	broad.mit.edu	37	19	38931492	38931492	+	Silent	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:38931492T>C	uc002oit.2	+	2	283	c.153T>C	c.(151-153)ACT>ACC	p.T51T	RYR1_uc002oiu.2_Silent_p.T51T	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	51	Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGGAGCCCACTAGCAACGCGC	0.642			NA											3	28					0	0	0.009096	0	0
RYR1	6261	broad.mit.edu	37	19	38976798	38976798	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:38976798G>C	uc002oit.2	+	34	5633	c.5503G>C	c.(5503-5505)GAG>CAG	p.E1835Q	RYR1_uc002oiu.2_Missense_Mutation_p.E1835Q	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1835	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGGCTCCGTGGAGTTCCAGTT	0.637			NA											19	145					0	0	0.008871	0	0
ADCK4	79934	broad.mit.edu	37	19	41211335	41211335	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:41211335C>G	uc002oor.2	-	6	687	c.385G>C	c.(385-387)GAC>CAC	p.D129H	ADCK4_uc002ooq.1_Intron|ADCK4_uc002oos.2_Missense_Mutation_p.D129H	NM_024876	NP_079152	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4 isoform a	129						integral to membrane	protein serine/threonine kinase activity				0			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			GGGCTGGAGTCCAGCCCAGAA	0.453			NA											7	48					0	0	0.001984	0	0
CCDC97	90324	broad.mit.edu	37	19	41822729	41822729	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:41822729C>T	uc002oqg.2	+	2	609	c.487C>T	c.(487-489)CGA>TGA	p.R163*	CYP2F1_uc010xvw.1_Intron	NM_052848	NP_443080	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	163											0						TGCTGCCCTGCGAGAGCTGAT	0.637			NA											8	33					0	0	0.008291	0	0
MEGF8	1954	broad.mit.edu	37	19	42861611	42861611	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:42861611G>A	uc002otl.3	+	27	5320	c.4685G>A	c.(4684-4686)CGA>CAA	p.R1562Q	MEGF8_uc002otm.3_Missense_Mutation_p.R1170Q	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1629	Extracellular (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				ACTGCCCGCCGAGGCCTGTCT	0.652			NA											11	69					0	0	0.00245	0	0
IRGC	56269	broad.mit.edu	37	19	44223193	44223193	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:44223193G>A	uc002oxh.2	+	2	630	c.483G>A	c.(481-483)AAG>AAA	p.K161K		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	161						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				GCCAGGGCAAGAAGTTCTACT	0.667	Colon(189;350 2037 11447 13433 38914)		NA											6	19					0	0	0.00308	0	0
PVRL2	5819	broad.mit.edu	37	19	45389236	45389236	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:45389236G>A	uc002ozw.1	+	7	1629	c.1239G>A	c.(1237-1239)GCG>GCA	p.A413A		NM_001042724	NP_001036189	Q92692	PVRL2_HUMAN	poliovirus receptor related 2 isoform delta	413	Cytoplasmic (Potential).				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		CCCCAAAAGCGAAGCTGGAGG	0.552			NA											4	58					0	0	0.009096	0	0
SYMPK	8189	broad.mit.edu	37	19	46352129	46352129	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:46352129C>T	uc002pdn.2	-	6	550	c.305G>A	c.(304-306)CGA>CAA	p.R102Q	SYMPK_uc002pdo.1_Missense_Mutation_p.R102Q|SYMPK_uc002pdp.1_Missense_Mutation_p.R102Q|SYMPK_uc002pdq.1_Missense_Mutation_p.R102Q	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	102	Interaction with HSF1.				cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CTCAATGTCTCGCTTGCTGAG	0.522			NA											21	66					0	0	0.002299	0	0
SYMPK	8189	broad.mit.edu	37	19	46355610	46355610	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:46355610C>T	uc002pdn.2	-	5	504	c.259G>A	c.(259-261)GAA>AAA	p.E87K	SYMPK_uc002pdo.1_Missense_Mutation_p.E87K|SYMPK_uc002pdp.1_Missense_Mutation_p.E87K|SYMPK_uc002pdq.1_Missense_Mutation_p.E87K	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	87	Interaction with HSF1.				cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		TTTCGCACTTCGATTGACTTG	0.542			NA											42	116					0	0	0.009718	0	0
SYMPK	8189	broad.mit.edu	37	19	46355787	46355787	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:46355787C>T	uc002pdn.2	-	4	423	c.178G>A	c.(178-180)GAG>AAG	p.E60K	SYMPK_uc002pdo.1_Missense_Mutation_p.E60K|SYMPK_uc002pdp.1_Missense_Mutation_p.E60K|SYMPK_uc002pdq.1_Missense_Mutation_p.E60K	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	60	Interaction with HSF1.				cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		ATGATCAGCTCCTGGACCTGG	0.443			NA											24	54					0	0	0.005443	0	0
SAE1	10055	broad.mit.edu	37	19	47706943	47706943	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:47706943G>T	uc002pgc.2	+	8	950	c.894G>T	c.(892-894)GAG>GAT	p.E298D	SAE1_uc002pgd.2_Missense_Mutation_p.R250I|SAE1_uc010ekx.2_Intron|SAE1_uc010ekw.2_RNA|SAE1_uc010xyk.1_Missense_Mutation_p.E124D|SAE1_uc002pge.2_Missense_Mutation_p.E234D	NM_016402	NP_057486	Q9UBE0	SAE1_HUMAN	SubName: Full=SUMO-1 activating enzyme subunit 1, isoform CRA_b; SubName: Full=cDNA, FLJ96708, Homo sapiens SUMO-1 activating enzyme subunit 1 (SAE1), mRNA;	298					protein sumoylation|protein ubiquitination	nucleus	ATP-dependent protein binding|enzyme activator activity|ligase activity|protein C-terminus binding|protein heterodimerization activity|ubiquitin activating enzyme activity			ovary(1)	1		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.00013)|OV - Ovarian serous cystadenocarcinoma(262;0.000146)|Epithelial(262;0.00697)|GBM - Glioblastoma multiforme(486;0.0278)		GCTTCTCCGAGATGGCCCCAG	0.458			NA											37	150					1.23713e-20	2.06875e-20	0.00361	1	0
KDELR1	10945	broad.mit.edu	37	19	48892941	48892941	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:48892941T>C	uc002pjb.1	-	3	415	c.220A>G	c.(220-222)ACG>GCG	p.T74A	KDELR1_uc002pja.1_Missense_Mutation_p.T12A	NM_006801	NP_006792	P24390	ERD21_HUMAN	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum	74	Helical; (Potential).				intracellular protein transport|protein retention in ER lumen|vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane|membrane fraction	KDEL sequence binding|protein binding|receptor activity				0		all_epithelial(76;2.48e-06)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Prostate(7;0.122)|Breast(70;0.203)		all cancers(93;0.000114)|OV - Ovarian serous cystadenocarcinoma(262;0.000136)|Epithelial(262;0.01)|GBM - Glioblastoma multiforme(486;0.0145)		AACCAGACCGTGGTGAAGGAG	0.552			NA											12	38					0	0	0.00245	0	0
SLC17A7	57030	broad.mit.edu	37	19	49938490	49938490	+	Silent	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:49938490A>G	uc002pnp.2	-	3	541	c.369T>C	c.(367-369)TTT>TTC	p.F123F	SLC17A7_uc002pnq.1_Silent_p.F56F	NM_020309	NP_064705	Q9P2U7	VGLU1_HUMAN	solute carrier family 17, member 7	123	Helical; (Potential).				glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			ovary(1)|pancreas(1)|skin(1)	3		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		AGCCCCAGAAAAAGGAGCCGT	0.512			NA											35	185					0	0	0.004878	0	0
KLK8	11202	broad.mit.edu	37	19	51499412	51499412	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:51499412C>A	uc002pur.1	-	6	865	c.686G>T	c.(685-687)GGC>GTC	p.G229V	KLK8_uc002puq.1_Missense_Mutation_p.G274V|KLK8_uc002pus.1_Missense_Mutation_p.G88V|KLK8_uc002put.1_3'UTR|KLK8_uc002puu.1_Missense_Mutation_p.G229V|KLK9_uc002puv.1_RNA	NM_007196	NP_009127	O60259	KLK8_HUMAN	kallikrein 8 isoform 1 preproprotein	229	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)	1		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		GGGGTCTGAGCCCCAGGATGT	0.567			NA											17	90					1.5739e-10	2.36871e-10	0.004007	1	0
SIGLEC9	27180	broad.mit.edu	37	19	51629379	51629379	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:51629379G>A	uc002pvu.2	+	3	809	c.742G>A	c.(742-744)GGC>AGC	p.G248S	SIGLEC9_uc010yct.1_Missense_Mutation_p.G248S	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	248	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		CCAAGGAGACGGCACAGGTAG	0.592			NA											4	63					0	0	0.000602	0	0
LILRB2	10288	broad.mit.edu	37	19	54783404	54783404	+	Missense_Mutation	SNP	C	C	A	rs140970769		TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:54783404C>A	uc002qfb.2	-	5	720	c.454G>T	c.(454-456)GGC>TGC	p.G152C	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.G152C|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.G152C|LILRB2_uc010yet.1_Missense_Mutation_p.G36C|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	152	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AGAATGAAGCCGCCAAATGCC	0.612			NA											14	65					1.52009e-12	2.36662e-12	0.003163	1	0
NLRP9	338321	broad.mit.edu	37	19	56244354	56244354	+	Silent	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:56244354T>C	uc002qly.2	-	2	871	c.843A>G	c.(841-843)CAA>CAG	p.Q281Q		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	281	NACHT.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		AATAGTGTTTTTGCATAGCCA	0.403			NA											15	68					0	0	0.004007	0	0
NLRP13	126204	broad.mit.edu	37	19	56424211	56424211	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:56424211C>T	uc010ygg.1	-	5	997	c.972G>A	c.(970-972)GAG>GAA	p.E324E		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	324	NACHT.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CATCCAAGCTCTCAGAGCGTG	0.453			NA											14	74					0	0	0.001855	0	0
ZNF154	7710	broad.mit.edu	37	19	58216288	58216288	+	Silent	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:58216288A>T	uc010euf.2	-	2	333	c.93T>A	c.(91-93)CTT>CTA	p.L31L	ZNF776_uc002qpx.2_Intron|ZNF154_uc002qpy.2_RNA	NM_001085384	NP_001078853	Q13106	ZN154_HUMAN	zinc finger protein 154	31	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GAGCCTCATCAAGGAGACCCC	0.507			NA											18	94					0	0	0.008871	0	0
A1BG	1	broad.mit.edu	37	19	58862863	58862863	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr19:58862863C>A	uc002qsd.3	-	5	866	c.804G>T	c.(802-804)GCG>GCT	p.A268A	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_RNA|NCRNA00181_uc002qsg.2_5'Flank	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	268	Ig-like V-type 3.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		CCAGGGCCACCGCGTTCAGGT	0.632			NA											11	34					6.40141e-05	7.8539e-05	0.000978	1	0
MYT1L	23040	broad.mit.edu	37	2	1926884	1926884	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:1926884G>A	uc002qxe.2	-	10	1484	c.657C>T	c.(655-657)GCC>GCT	p.A219A	MYT1L_uc002qxd.2_Silent_p.A219A|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	219					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		ACTCAGTCCTGGCCCGGTAGG	0.438			NA											8	53					0	0	0.006214	0	0
TSSC1	7260	broad.mit.edu	37	2	3217925	3217925	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:3217925C>A	uc002qxj.2	-	5	704	c.511G>T	c.(511-513)GCT>TCT	p.A171S	TSSC1_uc002qxi.2_RNA	NM_003310	NP_003301	Q53HC9	TSSC1_HUMAN	tumor suppressing subtransferable candidate 1	171	WD 1.						protein binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.212)		OV - Ovarian serous cystadenocarcinoma(76;0.00877)|Epithelial(75;0.0283)|all cancers(51;0.0464)		CTTACCACAGCCTGGCTCGAG	0.323	Colon(140;1261 1762 4183 34270 49743)		NA											7	96					2.17888e-05	2.74029e-05	0.006214	1	0
RRM2	6241	broad.mit.edu	37	2	10263908	10263908	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:10263908G>A	uc002rah.2	+	4	555	c.364G>A	c.(364-366)GAG>AAG	p.E122K		NM_001034	NP_001025	P31350	RIR2_HUMAN	ribonucleotide reductase M2 polypeptide isoform	122					deoxyribonucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol	ribonucleoside-diphosphate reductase activity|transition metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)|OV - Ovarian serous cystadenocarcinoma(76;0.221)		CCTGAAACCCGAGGAGAGATA	0.423			NA											12	125					0	0	0.001855	0	0
RRM2	6241	broad.mit.edu	37	2	10264847	10264847	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:10264847G>C	uc002rah.2	+	5	630	c.439G>C	c.(439-441)GAG>CAG	p.E147Q		NM_001034	NP_001025	P31350	RIR2_HUMAN	ribonucleotide reductase M2 polypeptide isoform	147					deoxyribonucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol	ribonucleoside-diphosphate reductase activity|transition metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)|OV - Ovarian serous cystadenocarcinoma(76;0.221)		CCACTAGGTGGAGCGATTTAG	0.403			NA											9	85					0	0	0.008291	0	0
C2orf44	80304	broad.mit.edu	37	2	24260771	24260771	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:24260771C>T	uc002rep.2	-	2	1725	c.1594G>A	c.(1594-1596)GAC>AAC	p.D532N	C2orf44_uc010eya.2_Missense_Mutation_p.D532N	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	532							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGGTGTGGTCTGGTGTGCTG	0.483			NA											4	44					0	0	0.000602	0	0
C2orf39	92749	broad.mit.edu	37	2	26673529	26673529	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:26673529C>A	uc002rhg.2	+	13	1743	c.1669C>A	c.(1669-1671)CGT>AGT	p.R557S		NM_145038	NP_659475	Q96MC2	CC164_HUMAN	hypothetical protein LOC92749	557											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCGAGCTCACCGTTTATCTTC	0.358			NA											9	97					0.000442599	0.00050913	0.006214	1	0
C2orf53	339779	broad.mit.edu	37	2	27360638	27360638	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:27360638C>A	uc002rjb.2	-	3	1140	c.560G>T	c.(559-561)GGG>GTG	p.G187V		NM_178553	NP_848648	Q53SZ7	CB053_HUMAN	hypothetical protein LOC339779	187											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCAGGGGACCCGGACCCAGT	0.647			NA											5	54					5.9392e-07	8.11361e-07	0.001168	1	0
BIRC6	57448	broad.mit.edu	37	2	32640306	32640306	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:32640306G>A	uc010ezu.2	+	10	2081	c.1947G>A	c.(1945-1947)ATG>ATA	p.M649I		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	649					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TTTCACAGATGAACAATATTA	0.378	Pancreas(94;175 1509 16028 18060 45422)		NA											4	42					0	0	0.009096	0	0
STRN	6801	broad.mit.edu	37	2	37096801	37096801	+	Silent	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:37096801G>C	uc002rpn.2	-	11	1404	c.1395C>G	c.(1393-1395)GGC>GGG	p.G465G	STRN_uc010ezx.2_Silent_p.G428G	NM_003162	NP_003153	O43815	STRN_HUMAN	striatin, calmodulin binding protein	465	WD 1.				dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			skin(1)	1		Ovarian(717;0.0129)|all_hematologic(82;0.21)				GGGCTCGGATGCCATCAAAGT	0.383			NA											5	36					0	0	0.000602	0	0
SLC8A1	6546	broad.mit.edu	37	2	40655828	40655828	+	Missense_Mutation	SNP	A	A	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:40655828A>C	uc002rrx.2	-	1	1617	c.1593T>G	c.(1591-1593)ATT>ATG	p.I531M	SLC8A1_uc002rry.2_Missense_Mutation_p.I531M|SLC8A1_uc002rrz.2_Missense_Mutation_p.I531M|SLC8A1_uc002rsa.2_Missense_Mutation_p.I531M|SLC8A1_uc002rsd.3_Missense_Mutation_p.I531M|SLC8A1_uc002rsb.1_Missense_Mutation_p.I531M|SLC8A1_uc010fan.1_Missense_Mutation_p.I531M|SLC8A1_uc002rsc.1_Missense_Mutation_p.I531M	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	531	Calx-beta 2.|Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CATCATCAAAAATAGTTACAG	0.438			NA											11	77					0	0	0.001855	0	0
SIX2	10736	broad.mit.edu	37	2	45233412	45233412	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:45233412G>A	uc002ruo.2	-	2	1066	c.773C>T	c.(772-774)CCG>CTG	p.P258L	SIX2_uc002rup.2_Missense_Mutation_p.P260L	NM_016932	NP_058628	Q9NPC8	SIX2_HUMAN	SIX homeobox 2	258						nucleus	sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GCCTGGCACCGGCACTGGCAC	0.706			NA											6	40					0	0	0.001168	0	0
EPCAM	4072	broad.mit.edu	37	2	47601119	47601119	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:47601119G>A	uc002rvx.2	+	3	715	c.357G>A	c.(355-357)GTG>GTA	p.V119V	EPCAM_uc002rvw.2_Silent_p.V147V	NM_002354	NP_002345	P16422	EPCAM_HUMAN	epithelial cell adhesion molecule precursor	119	Extracellular (Potential).|Thyroglobulin type-1.				positive regulation of cell proliferation	apical plasma membrane|basolateral plasma membrane|integral to membrane|lateral plasma membrane|tight junction	protein binding			skin(1)	1						GCTGGTGTGTGAACACTGCTG	0.522			NA							Lynch_syndrome				6	44					0	0	0.001168	0	0
MSH2	4436	broad.mit.edu	37	2	47690262	47690262	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:47690262G>T	uc002rvy.1	+	9	1547	c.1479G>T	c.(1477-1479)CAG>CAT	p.Q493H	MSH2_uc010yoh.1_Missense_Mutation_p.Q427H|MSH2_uc002rvz.2_Missense_Mutation_p.Q493H|MSH2_uc010fbg.2_Missense_Mutation_p.Q303H|MSH2_uc010fbh.1_RNA|MSH2_uc010fbi.1_RNA	NM_000251	NP_000242	P43246	MSH2_HUMAN	mutS homolog 2	493					B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding	p.?(2)		large_intestine(33)|haematopoietic_and_lymphoid_tissue(6)|endometrium(4)|ovary(3)|cervix(2)|central_nervous_system(2)|stomach(1)|small_intestine(1)|breast(1)|skin(1)|prostate(1)	55		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AGAAGATGCAGTCAACATTAA	0.348			NA	D|Mis|N|F|S		colorectal|endometrial|ovarian	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				16	88					1.45105e-14	2.32735e-14	0.006122	1	0
FAM161A	84140	broad.mit.edu	37	2	62067223	62067223	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:62067223G>A	uc010ypo.1	-	3	1018	c.916C>T	c.(916-918)CGG>TGG	p.R306W	FAM161A_uc002sbm.3_Missense_Mutation_p.R306W|FAM161A_uc002sbn.3_Missense_Mutation_p.R116W|FAM161A_uc010fcm.1_RNA|FAM161A_uc010fcn.1_Missense_Mutation_p.R197W	NM_032180	NP_115556	Q3B820	F161A_HUMAN	hypothetical protein LOC84140	306	Potential.				response to stimulus|visual perception	centrosome				large_intestine(2)|ovary(1)	3						GACCTTCTCCGTTCTTCTTTT	0.443			NA											28	206					0	0	0.008361	0	0
PLEK	5341	broad.mit.edu	37	2	68607999	68607999	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:68607999A>T	uc002sen.3	+	3	505	c.343A>T	c.(343-345)AGG>TGG	p.R115W	PLEK_uc010fde.2_Missense_Mutation_p.R115W	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	115					actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		GAAATCTACCAGGAGGTCCAT	0.468			NA											30	173					0	0	0.002445	0	0
ZNF638	27332	broad.mit.edu	37	2	71650945	71650945	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:71650945C>G	uc002shx.2	+	22	4620	c.4301C>G	c.(4300-4302)GCC>GGC	p.A1434G	ZNF638_uc010yqw.1_Missense_Mutation_p.A1013G|ZNF638_uc002shy.2_Missense_Mutation_p.A1434G|ZNF638_uc002shz.2_Missense_Mutation_p.A1434G|ZNF638_uc002sia.2_Missense_Mutation_p.A1434G|ZNF638_uc002sib.1_Intron|ZNF638_uc010fed.2_Intron|ZNF638_uc002sic.2_Missense_Mutation_p.A531G|ZNF638_uc002sid.2_Intron	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	1434					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						AAACTTTCAGCCAAGGAATTT	0.418			NA											4	37					0	0	0.000602	0	0
C2orf78	388960	broad.mit.edu	37	2	74043355	74043355	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:74043355C>A	uc002sjr.1	+	3	2126	c.2005C>A	c.(2005-2007)CCA>ACA	p.P669T		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	669										ovary(2)	2						CCAGCCATTCCCAGCTCTCAA	0.483			NA											13	40					9.31168e-06	1.21334e-05	0.001855	1	0
NCAPH	23397	broad.mit.edu	37	2	97031791	97031791	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:97031791C>T	uc002svz.1	+	14	1960	c.1876C>T	c.(1876-1878)CAG>TAG	p.Q626*	NCAPH_uc010fhv.1_Nonsense_Mutation_p.Q615*|NCAPH_uc010yum.1_Nonsense_Mutation_p.Q602*|NCAPH_uc010fhw.1_Nonsense_Mutation_p.Q615*|NCAPH_uc010yun.1_Nonsense_Mutation_p.Q490*|NCAPH_uc002swa.1_Nonsense_Mutation_p.Q221*	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	626					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				AGCTGAGCCTCAGAAGGTACG	0.418			NA											10	44					0	0	0.008291	0	0
VWA3B	200403	broad.mit.edu	37	2	98709612	98709612	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:98709612G>T	uc002syo.2	+	2	321	c.57G>T	c.(55-57)GAG>GAT	p.E19D	VWA3B_uc010yvh.1_Translation_Start_Site|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_Translation_Start_Site|VWA3B_uc002sym.2_Missense_Mutation_p.E19D|VWA3B_uc002syn.1_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	19										ovary(3)|large_intestine(2)|skin(1)	6						AGAGGCAAGAGGGATGGATTA	0.458			NA											8	60					0.00307968	0.00339969	0.00308	1	0
SLC9A4	389015	broad.mit.edu	37	2	103090357	103090357	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:103090357G>T	uc002tbz.3	+	1	596	c.139G>T	c.(139-141)GCT>TCT	p.A47S		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	47	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						CGCTTGGTTTGCTGCTGCCAG	0.433			NA											26	174					1.2476e-16	2.02988e-16	0.00632	1	0
ST6GAL2	84620	broad.mit.edu	37	2	107460128	107460128	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:107460128G>T	uc002tdq.2	-	2	425	c.306C>A	c.(304-306)TCC>TCA	p.S102S	ST6GAL2_uc002tdr.2_Silent_p.S102S|ST6GAL2_uc002tds.3_Silent_p.S102S	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	102	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						ACCCATCTTGGGACTGGGCCC	0.587			NA											21	89					2.37509e-13	3.76265e-13	0.010504	1	0
RANBP2	5903	broad.mit.edu	37	2	109384690	109384690	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:109384690G>T	uc002tem.3	+	20	7821	c.7695G>T	c.(7693-7695)CAG>CAT	p.Q2565H		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2565					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						CAGTAGCCCAGAGTGGATCTG	0.378			NA											42	278					1.52319e-26	2.57572e-26	0.00874	1	0
POLR1B	84172	broad.mit.edu	37	2	113305083	113305083	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:113305083A>T	uc002thw.2	+	3	1011	c.431A>T	c.(430-432)AAG>ATG	p.K144M	POLR1B_uc010fkn.2_Missense_Mutation_p.K88M|POLR1B_uc002thx.2_Missense_Mutation_p.K5M|POLR1B_uc010fko.2_Missense_Mutation_p.K144M|POLR1B_uc010fkp.2_Intron|POLR1B_uc010yxn.1_Missense_Mutation_p.K182M|POLR1B_uc002thy.2_Missense_Mutation_p.K5M|POLR1B_uc010yxo.1_Intron	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	RNA polymerase I polypeptide B isoform 1	144					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(1)	1						GTGAAATCCAAGCTTTGCAAC	0.468	Ovarian(16;256 576 9537 23969 41147)		NA											19	105					0	0	0.006122	0	0
TFCP2L1	29842	broad.mit.edu	37	2	121995289	121995289	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:121995289G>T	uc002tmx.2	-	10	1006	c.913C>A	c.(913-915)CTG>ATG	p.L305M	TFCP2L1_uc010flr.2_Missense_Mutation_p.L305M	NM_014553	NP_055368	Q9NZI6	TF2L1_HUMAN	LBP-9	305					female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			pancreas(2)|ovary(1)	3	Renal(3;0.01)					GATGGGAGCAGGTGCTGTGAG	0.607			NA											4	60					0.00024832	0.000291212	0.009096	1	0
MYO7B	4648	broad.mit.edu	37	2	128393797	128393797	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:128393797C>A	uc002top.2	+	44	5996	c.5943C>A	c.(5941-5943)GCC>GCA	p.A1981A	MYO7B_uc002tos.1_Silent_p.A91A|MYO7B_uc002tot.2_Silent_p.A91A	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1981	FERM 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TCCTTCTAGCCTATGACAAGC	0.622			NA											8	64					0.00307968	0.00339969	0.00308	1	0
POTEF	728378	broad.mit.edu	37	2	130832523	130832523	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:130832523G>T	uc010fmh.2	-	17	2922	c.2522C>A	c.(2521-2523)TCC>TAC	p.S841Y		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	841	Actin-like.					cell cortex	ATP binding			skin(3)|ovary(2)	5						GGTGTACAGGGACAGCACAGC	0.592			NA											12	92					8.60227e-14	1.37241e-13	0.004007	1	0
GPR148	344561	broad.mit.edu	37	2	131487629	131487629	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:131487629C>A	uc002trv.1	+	1	907	c.905C>A	c.(904-906)GCA>GAA	p.A302E		NM_207364	NP_997247	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	302	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1	Colorectal(110;0.1)					TGGCTCCTGGCAGCTAACAGT	0.582			NA											11	64					0.00010058	0.000120616	0.001368	1	0
LOC401010	401010	broad.mit.edu	37	2	132200526	132200526	+	Silent	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:132200526A>T	uc002tst.2	-	1	1942	c.1476T>A	c.(1474-1476)CCT>CCA	p.P492P		NR_002826				SubName: Full=cDNA FLJ12694 fis, clone NT2RP1000358, highly similar to Homo sapiens mRNA; cDNA DKFZp564C186 (from clone DKFZp564C186);												0						GTTTGATCTCAGGAAAGTTCA	0.537			NA											7	53					0	0	0.001984	0	0
TUBA3D	113457	broad.mit.edu	37	2	132237812	132237812	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:132237812G>A	uc002tsu.3	+	4	653	c.546G>A	c.(544-546)GTG>GTA	p.V182V		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	182					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		CAGCCGTGGTGGAGCCCTACA	0.552	Ovarian(137;2059 2432 35543 39401)		NA											16	196					0	0	0.007413	0	0
NCKAP5	344148	broad.mit.edu	37	2	133542855	133542855	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:133542855C>A	uc002ttp.2	-	14	1903	c.1529G>T	c.(1528-1530)AGT>ATT	p.S510I	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	510							protein binding				0						GCCAAACAGACTGTCGGAAAC	0.507			NA											19	142					3.32936e-07	4.57597e-07	0.006122	1	0
YSK4	80122	broad.mit.edu	37	2	135744683	135744683	+	Silent	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:135744683A>G	uc002tue.1	-	7	1790	c.1759T>C	c.(1759-1761)TTG>CTG	p.L587L	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Silent_p.L474L|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Silent_p.L315L|YSK4_uc002tui.3_Silent_p.L604L	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	587							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		AACCTGGGCAATTGCCAAGGC	0.423			NA											25	170					0	0	0.00278	0	0
Unknown	0	broad.mit.edu	37	2	139045943	139045943	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:139045943T>C	uc010zbk.1	-	1	498	c.355A>G	c.(355-357)AGG>GGG	p.R119G						SubName: Full=cDNA, FLJ79100, highly similar to 14-3-3 protein epsilon (14-3-3E);												NA						GCCTCCTTCCTGTCATTTCCT	0.453			NA											23	126					0	0	0.00333	0	0
LRP1B	53353	broad.mit.edu	37	2	141027886	141027886	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:141027886C>G	uc002tvj.1	-	86	14144	c.13172G>C	c.(13171-13173)TGT>TCT	p.C4391S		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4391	Extracellular (Potential).|EGF-like 14.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACATAACTGACAGCTAGAGGC	0.413	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			6	55					0	0	0.001168	0	0
LRP1B	53353	broad.mit.edu	37	2	141108599	141108599	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:141108599C>G	uc002tvj.1	-	77	12631	c.11659G>C	c.(11659-11661)GAT>CAT	p.D3887H		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3887	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGAACTTGATCTTCAGAGCCT	0.254	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			8	57					0	0	0.00308	0	0
LRP1B	53353	broad.mit.edu	37	2	141474375	141474375	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:141474375G>T	uc002tvj.1	-	36	6741	c.5769C>A	c.(5767-5769)ACC>ACA	p.T1923T		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1923	Extracellular (Potential).|LDL-receptor class B 19.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCCAGTAGATGGTATCATTTT	0.353	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			4	54					0.00024832	0.000291212	0.009096	1	0
MBD5	55777	broad.mit.edu	37	2	149247498	149247498	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:149247498G>T	uc002twm.3	+	12	4586	c.3598G>T	c.(3598-3600)GAG>TAG	p.E1200*	MBD5_uc010zbs.1_Intron|MBD5_uc010fns.2_Nonsense_Mutation_p.E1200*|MBD5_uc002two.2_Nonsense_Mutation_p.E458*|MBD5_uc002twp.2_Nonsense_Mutation_p.E250*	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1200						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		GTGGGACGGGGAGCAAAGCCC	0.473			NA											5	82					1.23904e-05	1.57585e-05	0.000602	1	0
SCN2A	6326	broad.mit.edu	37	2	166179847	166179847	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:166179847G>A	uc002udc.2	+	12	2143	c.1853G>A	c.(1852-1854)GGA>GAA	p.G618E	SCN2A_uc002udd.2_Missense_Mutation_p.G618E|SCN2A_uc002ude.2_Missense_Mutation_p.G618E	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	618					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	CACAGACATGGAGAACGGCGC	0.557			NA											3	28					0	0	0.004672	0	0
CSRNP3	80034	broad.mit.edu	37	2	166535349	166535349	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:166535349G>T	uc002udf.2	+	7	1220	c.844G>T	c.(844-846)GAG>TAG	p.E282*	CSRNP3_uc002udg.2_Nonsense_Mutation_p.E282*	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	282					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						GAAAAACCGAGAGCAGCAAAT	0.448			NA											7	56					8.12818e-05	9.7994e-05	0.001984	1	0
SCN1A	6323	broad.mit.edu	37	2	166900551	166900551	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:166900551C>T	uc010zcz.1	-	11	1689	c.1671G>A	c.(1669-1671)TTG>TTA	p.L557L	SCN1A_uc002udo.3_Silent_p.L426L|SCN1A_uc010fpk.2_Silent_p.L426L	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	557						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CACGGATGCTCAACAAAGACT	0.393			NA											5	37					0	0	0.000602	0	0
XIRP2	129446	broad.mit.edu	37	2	168102966	168102966	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:168102966C>A	uc002udx.2	+	8	5082	c.5064C>A	c.(5062-5064)AAC>AAA	p.N1688K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.N1513K|XIRP2_uc010fpq.2_Missense_Mutation_p.N1466K|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1513					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GAGATATTAACATGACTATCT	0.338			NA											8	60					5.68852e-11	8.61869e-11	0.004482	1	0
XIRP2	129446	broad.mit.edu	37	2	168108197	168108197	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:168108197C>A	uc002udx.2	+	8	10313	c.10295C>A	c.(10294-10296)TCG>TAG	p.S3432*	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Nonsense_Mutation_p.S3257*|XIRP2_uc010fpq.2_Nonsense_Mutation_p.S3210*|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3257					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ATTGTTGAGTCGAAGATGAAA	0.453			NA											4	73					0.00909568	0.00978951	0.009096	1	0
TTN	7273	broad.mit.edu	37	2	179404336	179404336	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:179404336G>T	uc010zfg.1	-	301	90976	c.90752C>A	c.(90751-90753)CCT>CAT	p.P30251H	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P23946H|TTN_uc010zfi.1_Missense_Mutation_p.P23879H|TTN_uc010zfj.1_Missense_Mutation_p.P23754H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31178							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCAGCAGGAGGTCTCCAGCT	0.527			NA											19	137					7.45023e-12	1.15001e-11	0.010504	1	0
TTN	7273	broad.mit.edu	37	2	179422925	179422925	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:179422925G>T	uc010zfg.1	-	277	79676	c.79452C>A	c.(79450-79452)CAC>CAA	p.H26484Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.H20179Q|TTN_uc010zfi.1_Missense_Mutation_p.H20112Q|TTN_uc010zfj.1_Missense_Mutation_p.H19987Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27411							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATATACAGTGTGACTTGGGA	0.353			NA											5	43					1.23904e-05	1.57585e-05	0.000602	1	0
TTN	7273	broad.mit.edu	37	2	179448526	179448526	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:179448526C>T	uc010zfg.1	-	261	57903	c.57679G>A	c.(57679-57681)GAA>AAA	p.E19227K	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E12922K|TTN_uc010zfi.1_Missense_Mutation_p.E12855K|TTN_uc010zfj.1_Missense_Mutation_p.E12730K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20154							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGCAAGCTTCTACGAAATAG	0.463			NA											6	22					0	0	0.001984	0	0
TTN	7273	broad.mit.edu	37	2	179459287	179459287	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:179459287C>T	uc010zfg.1	-	245	50454	c.50230G>A	c.(50230-50232)GGT>AGT	p.G16744S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G10439S|TTN_uc010zfi.1_Missense_Mutation_p.G10372S|TTN_uc010zfj.1_Missense_Mutation_p.G10247S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17671							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGACCCACCATCATACTTA	0.393			NA											19	107					0	0	0.010504	0	0
ITGA4	3676	broad.mit.edu	37	2	182339987	182339987	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:182339987G>T	uc002unu.2	+	4	1291	c.528G>T	c.(526-528)CTG>CTT	p.L176L	ITGA4_uc010zfl.1_Silent_p.L176L	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	176	FG-GAP 2.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GAACAGAACTGAGTAAAAGAA	0.343			NA											15	91					1.15088e-07	1.59393e-07	0.004007	1	0
ZNF804A	91752	broad.mit.edu	37	2	185801020	185801020	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:185801020C>A	uc002uph.2	+	4	1491	c.897C>A	c.(895-897)GTC>GTA	p.V299V		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	299						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TAAAAGAAGTCTCTAGTGAAA	0.353			NA											6	40					8.12818e-05	9.7994e-05	0.001984	1	0
ZNF804A	91752	broad.mit.edu	37	2	185803016	185803016	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:185803016C>A	uc002uph.2	+	4	3487	c.2893C>A	c.(2893-2895)CAG>AAG	p.Q965K		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	965						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TAGACAGTCACAGCCTAAATC	0.388			NA											18	95					1.33834e-09	1.97148e-09	0.007413	1	0
FAM171B	165215	broad.mit.edu	37	2	187605101	187605101	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:187605101T>A	uc002ups.2	+	2	497	c.385T>A	c.(385-387)TAC>AAC	p.Y129N	FAM171B_uc002upr.1_Missense_Mutation_p.Y129N	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	129	Extracellular (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						AAAAGTACCCTACAAATTAGG	0.393			NA											7	39					0	0	0.00308	0	0
STK17B	9262	broad.mit.edu	37	2	197008376	197008376	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:197008376A>T	uc002utk.2	-	5	839	c.515T>A	c.(514-516)CTC>CAC	p.L172H	STK17B_uc010fsh.2_Missense_Mutation_p.L172H	NM_004226	NP_004217	O94768	ST17B_HUMAN	serine/threonine kinase 17B	172	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity			lung(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.141)			AATGTCCCCGAGAGGGTATAT	0.353			NA											12	101					0	0	0.001368	0	0
ANKRD44	91526	broad.mit.edu	37	2	197872649	197872649	+	Splice_Site	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:197872649T>A	uc002uua.1	-	20	2015	c.1938_splice	c.e20-1	p.Q646_splice	ANKRD44_uc002utz.3_Splice_Site_p.Q378_splice	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44								protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			AGTGGTGTTCTAGGCAGAGAG	0.403			NA											13	89					0	0	0.001855	0	0
SATB2	23314	broad.mit.edu	37	2	200137156	200137156	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:200137156G>C	uc002uuy.1	-	11	2797	c.1980C>G	c.(1978-1980)ATC>ATG	p.I660M	SATB2_uc010fsq.1_Missense_Mutation_p.I542M|SATB2_uc002uuz.1_Missense_Mutation_p.I660M|SATB2_uc002uva.1_Missense_Mutation_p.I660M	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	660	Homeobox.					cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGAAGAACTTGATGATGGTGT	0.547	Colon(30;262 767 11040 24421 36230)		NA											7	98					0	0	0.001984	0	0
FAM126B	285172	broad.mit.edu	37	2	201853122	201853122	+	Nonsense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:201853122G>C	uc002uws.3	-	11	1042	c.854C>G	c.(853-855)TCA>TGA	p.S285*	FAM126B_uc002uwu.2_Nonsense_Mutation_p.S203*|FAM126B_uc002uwv.2_Nonsense_Mutation_p.S285*	NM_173822	NP_776183	Q8IXS8	F126B_HUMAN	hypothetical protein LOC285172	285						intracellular				ovary(1)	1						AAATGGTAATGAGTTTTTCAT	0.358			NA											9	92					0	0	0.000978	0	0
CDK15	65061	broad.mit.edu	37	2	202700488	202700488	+	Splice_Site	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:202700488T>A	uc002uyt.2	+	8	900	c.851_splice	c.e8+2	p.W284_splice	CDK15_uc010ftm.2_Splice_Site_p.W149_splice|CDK15_uc002uys.2_Splice_Site_p.W233_splice|CDK15_uc010ftn.1_Splice_Site_p.W233_splice|CDK15_uc010fto.1_Splice_Site_p.W263_splice	NM_139158	NP_631897	Q96Q40	CDK15_HUMAN	PFTAIRE protein kinase 2								ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)	GGACATATGGTAAGAGTGGTG	0.438			NA											7	32					0	0	0.004482	0	0
BMPR2	659	broad.mit.edu	37	2	203332383	203332383	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:203332383A>G	uc002uzf.3	+	3	1537	c.389A>G	c.(388-390)AAT>AGT	p.N130S	BMPR2_uc010ftr.2_Missense_Mutation_p.N130S|BMPR2_uc002uze.2_Missense_Mutation_p.N130S	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	130	Extracellular (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						TTTACTGAGAATTTTCCACCT	0.348			NA											17	86					0	0	0.006122	0	0
CRYGB	1419	broad.mit.edu	37	2	209007476	209007476	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:209007476G>A	uc002vcp.3	-	3	447	c.414C>T	c.(412-414)CCC>CCT	p.P138P		NM_005210	NP_005201	P07316	CRGB_HUMAN	crystallin, gamma B	138	Beta/gamma crystallin 'Greek key' 4.				visual perception		structural constituent of eye lens				0				Epithelial(149;0.0641)|LUSC - Lung squamous cell carcinoma(261;0.0703)|Lung(261;0.132)		CCCTGTAGTTGGGCATCTCAT	0.542			NA											21	127					0	0	0.002299	0	0
PTH2R	5746	broad.mit.edu	37	2	209308240	209308240	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:209308240C>A	uc002vdb.2	+	6	890	c.677C>A	c.(676-678)ACT>AAT	p.T226N	PTH2R_uc010zjb.1_Missense_Mutation_p.T237N	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	226	Extracellular (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		ATTGAGGCAACTTCTGTGGAC	0.368			NA											9	88					1.12685e-05	1.45156e-05	0.004482	1	0
MAP2	4133	broad.mit.edu	37	2	210558419	210558419	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:210558419G>A	uc002vde.1	+	7	1773	c.1525G>A	c.(1525-1527)GAT>AAT	p.D509N	MAP2_uc002vdc.1_Missense_Mutation_p.D509N|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.D505N	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	509					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AGCAGTTACAGATTCAGCCAT	0.428	Pancreas(27;423 979 28787 29963)		NA											8	80					0	0	0.004482	0	0
CPS1	1373	broad.mit.edu	37	2	211464141	211464141	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:211464141G>T	uc002vee.3	+	14	1537	c.1405G>T	c.(1405-1407)GTC>TTC	p.V469F	CPS1_uc010fur.2_Missense_Mutation_p.V475F|CPS1_uc010fus.2_Missense_Mutation_p.V18F	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	469					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CATTGCATCAGTCCAGACCAA	0.418			NA											22	88					1.10513e-12	1.72952e-12	0.002299	1	0
SPAG16	79582	broad.mit.edu	37	2	214215336	214215336	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:214215336G>T	uc002veq.2	+	7	821	c.729G>T	c.(727-729)CTG>CTT	p.L243L	SPAG16_uc010fuz.1_Silent_p.L94L|SPAG16_uc002ver.2_Silent_p.L189L|SPAG16_uc010zjk.1_Silent_p.L149L|SPAG16_uc002vep.1_Intron|SPAG16_uc002ves.1_Silent_p.L212L	NM_024532	NP_078808	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16 isoform 1	243	Potential.				cilium assembly	cilium axoneme|flagellar axoneme				ovary(1)|skin(1)	2		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		AGAAAATGCTGACCTCCTTGG	0.313			NA											9	76					6.42651e-13	1.011e-12	0.000978	1	0
BARD1	580	broad.mit.edu	37	2	215595194	215595194	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:215595194C>A	uc002veu.2	-	10	2077	c.1942G>T	c.(1942-1944)GAA>TAA	p.E648*	BARD1_uc010zjm.1_Nonsense_Mutation_p.E504*	NM_000465	NP_000456	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	648	BRCT 1.				cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TACTTTTCTTCCTGTTCACAT	0.353			NA							Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				11	65					9.31168e-06	1.21334e-05	0.001855	1	0
RNF25	64320	broad.mit.edu	37	2	219528862	219528862	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:219528862C>T	uc002vit.2	-	10	1286	c.1198G>A	c.(1198-1200)GAG>AAG	p.E400K	RNF25_uc010fvw.2_Missense_Mutation_p.E288K	NM_022453	NP_071898	Q96BH1	RNF25_HUMAN	ring finger protein 25	400					positive regulation of NF-kappaB transcription factor activity	cytosol|nucleus	NF-kappaB binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;6.99e-07)|all cancers(144;0.000129)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGCCCCTTCTCTTGTGGAGGA	0.647			NA											24	184					0	0	0.00278	0	0
WNT10A	80326	broad.mit.edu	37	2	219746998	219746998	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:219746998C>T	uc002vjd.1	+	2	692	c.229C>T	c.(229-231)CGT>TGT	p.R77C		NM_025216	NP_079492	Q9GZT5	WN10A_HUMAN	wingless-type MMTV integration site family,	77					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|female gonad development|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentine-containing tooth|sebaceous gland development|skin development|tongue development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			lung(1)|skin(1)	2		Renal(207;0.0474)		Epithelial(149;4.26e-07)|all cancers(144;8.8e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGTGTGTGTGCGTCACCCTGA	0.612			NA											8	44					0	0	0.006214	0	0
SPEG	10290	broad.mit.edu	37	2	220338272	220338272	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:220338272C>G	uc010fwg.2	+	17	4194	c.4194C>G	c.(4192-4194)ATC>ATG	p.I1398M		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1398	Ig-like 7.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AACCAGACATCGTGTATGTGG	0.498			NA											22	159					0	0	0.00333	0	0
WDFY1	57590	broad.mit.edu	37	2	224763777	224763777	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:224763777C>A	uc002vnq.2	-	6	547	c.496G>T	c.(496-498)GAC>TAC	p.D166Y		NM_020830	NP_065881	Q8IWB7	WDFY1_HUMAN	WD repeat and FYVE domain containing 1	166	WD 4.					cytosol|early endosome|nucleus	1-phosphatidylinositol binding|zinc ion binding			lung(1)	1		all_lung(227;0.00682)|Lung NSC(271;0.00859)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;5.34e-10)|all cancers(144;1.67e-07)|Lung(261;0.00807)|LUSC - Lung squamous cell carcinoma(224;0.00843)		TACTGAGTGTCAAAGTCATAT	0.423			NA											10	62					0.00621372	0.00673588	0.006214	1	0
KIAA1486	57624	broad.mit.edu	37	2	226446722	226446722	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:226446722C>A	uc002voe.2	+	4	764	c.589C>A	c.(589-591)CGA>AGA	p.R197R	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_5'UTR	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	197										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		CAAACCGAAGCGAAATCCGAA	0.498			NA											22	181					1.50039e-11	2.30417e-11	0.001882	1	0
TRIP12	9320	broad.mit.edu	37	2	230661452	230661452	+	Nonsense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:230661452G>C	uc002vpw.1	-	24	3555	c.3446C>G	c.(3445-3447)TCA>TGA	p.S1149*	TRIP12_uc002vpx.1_Nonsense_Mutation_p.S1197*|TRIP12_uc002vpy.1_Nonsense_Mutation_p.S879*|TRIP12_uc010zlz.1_RNA	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1149					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		ATCTGACTCTGAGACTATGCT	0.373			NA											12	59					0	0	0.001368	0	0
TRPM8	79054	broad.mit.edu	37	2	234878914	234878914	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:234878914C>A	uc002vvh.2	+	17	2239	c.2199C>A	c.(2197-2199)TCC>TCA	p.S733S	TRPM8_uc010fyj.2_Intron	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	733	Extracellular (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	TCTTCACCTCCCCCTTCGTGG	0.537			NA											45	304					1.03325e-14	1.66909e-14	0.002852	1	0
AGAP1	116987	broad.mit.edu	37	2	236957737	236957737	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:236957737C>T	uc002vvs.2	+	16	2521	c.1926C>T	c.(1924-1926)CTC>CTT	p.L642L	AGAP1_uc002vvt.2_Silent_p.L589L	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	642	C4-type.|Arf-GAP.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3						TGGGAGCCCTCATGTGCATCG	0.537			NA											6	84					0	0	0.001984	0	0
IQCA1	79781	broad.mit.edu	37	2	237272522	237272522	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:237272522G>A	uc002vvz.1	-	15	1952	c.1770C>T	c.(1768-1770)ACC>ACT	p.T590T	IQCA1_uc002vwb.2_Silent_p.T598T|IQCA1_uc002vwa.1_RNA|IQCA1_uc010zni.1_Silent_p.T549T	NM_024726	NP_079002	Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	590							ATP binding			ovary(1)	1						CTCCCGTTTCGGTGCAGATGG	0.517			NA											6	111					0	0	0.001168	0	0
C20orf54	113278	broad.mit.edu	37	20	744288	744288	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:744288G>A	uc002wed.3	-	3	1266	c.927C>T	c.(925-927)TTC>TTT	p.F309F	C20orf54_uc002wee.2_Silent_p.F309F	NM_033409	NP_212134	Q9NQ40	RFT2_HUMAN	hypothetical protein LOC113278 precursor	309	Helical; (Potential).				sensory perception of sound	integral to plasma membrane	riboflavin transporter activity			ovary(2)	2						GCGCGTTGACGAAGGCCACCA	0.637			NA											8	68					0	0	0.006214	0	0
ADAM33	80332	broad.mit.edu	37	20	3655286	3655286	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:3655286G>T	uc002wit.2	-	6	552	c.465C>A	c.(463-465)CCC>CCA	p.P155P	ADAM33_uc002wir.1_Silent_p.P155P|ADAM33_uc002wis.2_5'Flank|ADAM33_uc002wiu.2_Silent_p.P155P|ADAM33_uc002wiw.1_Intron|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Intron|ADAM33_uc002wix.1_Intron|ADAM33_uc010zqg.1_Silent_p.P167P|ADAM33_uc010zqh.1_Silent_p.P155P	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	155	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						TGGAGCCCCGGGGTGGCCAGG	0.607			NA											16	130					2.23348e-06	2.96158e-06	0.004007	1	0
C20orf196	149840	broad.mit.edu	37	20	5843764	5843764	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:5843764G>T	uc002wmf.2	+	3	360	c.273G>T	c.(271-273)GAG>GAT	p.E91D		NM_152504	NP_689717	Q8IYI0	CT196_HUMAN	hypothetical protein LOC149840	91											0						AGAAGGAAGAGGATGATGGCC	0.473			NA											8	43					5.18039e-06	6.79926e-06	0.00308	1	0
CSTL1	128817	broad.mit.edu	37	20	23420937	23420937	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:23420937G>T	uc002wte.2	+	2	279	c.33G>T	c.(31-33)CTG>CTT	p.L11L	CSTL1_uc010zsu.1_RNA|CSTL1_uc010zsv.1_RNA	NM_138283	NP_612140	Q9H114	CST1L_HUMAN	cystatin-like 1 precursor	11						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0993)|Lung NSC(19;0.235)					ACCCCCTGCTGCTGCTGATTG	0.552			NA											16	66					0.00498961	0.005435	0.00499	1	0
C20orf112	140688	broad.mit.edu	37	20	31043985	31043985	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:31043985G>A	uc002wxu.3	-	3	480	c.323C>T	c.(322-324)TCG>TTG	p.S108L	C20orf112_uc010gec.2_5'UTR	NM_080616	NP_542183	Q96MY1	CT112_HUMAN	hypothetical protein LOC140688	108											0						GCAGCCATCCGAGGGGTAGGA	0.667			NA											12	96					0	0	0.000978	0	0
GDF5	8200	broad.mit.edu	37	20	34022057	34022057	+	Missense_Mutation	SNP	T	T	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:34022057T>G	uc002xck.1	-	2	1475	c.1156A>C	c.(1156-1158)ACT>CCT	p.T386P	GDF5_uc010gfc.1_Missense_Mutation_p.T386P|uc002xcj.2_Missense_Mutation_p.S156R|GDF5_uc010zvc.1_Missense_Mutation_p.T386P	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	386					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			CCCTGGCGAGTGGCCAGTGGG	0.577			NA											15	143					0	0	0.010504	0	0
FAM83D	81610	broad.mit.edu	37	20	37580296	37580296	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:37580296C>T	uc002xjg.2	+	4	1022	c.981C>T	c.(979-981)ATC>ATT	p.I327I		NM_030919	NP_112181	Q9H4H8	FA83D_HUMAN	hypothetical protein LOC81610	297					cell division|mitosis	cytoplasm|spindle pole				ovary(3)	3		Myeloproliferative disorder(115;0.00878)				CCAAGCCCATCAGCCCCAAAC	0.502			NA											9	80					0	0	0.004482	0	0
PABPC1L	80336	broad.mit.edu	37	20	43559182	43559182	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:43559182G>C	uc010ggv.1	+	8	1136	c.1054G>C	c.(1054-1056)GAG>CAG	p.E352Q	PABPC1L_uc010zwq.1_RNA|PABPC1L_uc002xmv.2_RNA|PABPC1L_uc002xmw.2_5'Flank|PABPC1L_uc002xmx.2_5'Flank	NM_001124756	NP_001118228	Q4VXU2	PAP1L_HUMAN	poly(A)-binding protein, cytoplasmic 1-like	352	RRM 4.						nucleotide binding|RNA binding			ovary(1)	1						GGCCGTGACAGAGATGAACGG	0.567			NA											35	208					0	0	0.003271	0	0
CDH22	64405	broad.mit.edu	37	20	44803585	44803585	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:44803585A>T	uc002xrm.2	-	11	2448	c.2047T>A	c.(2047-2049)TAC>AAC	p.Y683N	CDH22_uc010ghk.1_Missense_Mutation_p.Y683N	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	683	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				GACATGTCGTAGGCTTCGGTG	0.443			NA											4	39					0	0	0.000602	0	0
PREX1	57580	broad.mit.edu	37	20	47265957	47265957	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:47265957C>A	uc002xtw.1	-	25	3209	c.3186G>T	c.(3184-3186)CGG>CGT	p.R1062R	PREX1_uc002xtv.1_Silent_p.R359R	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	1062					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			AGCTGAGGCCCCGGTCTTCCT	0.602			NA											7	64					2.0095e-06	2.67637e-06	0.001984	1	0
FAM65C	140876	broad.mit.edu	37	20	49209638	49209638	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:49209638G>A	uc002xvm.2	-	18	2614	c.2296C>T	c.(2296-2298)CAC>TAC	p.H766Y	FAM65C_uc010zyt.1_Missense_Mutation_p.H770Y|FAM65C_uc010zyu.1_RNA	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	766										ovary(2)	2						AGGTAGCTGTGAAACTGGAAC	0.607			NA											13	94					0	0	0.001368	0	0
TSHZ2	128553	broad.mit.edu	37	20	51872567	51872567	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:51872567A>T	uc002xwo.2	+	2	3526	c.2570A>T	c.(2569-2571)CAA>CTA	p.Q857L		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	857	Homeobox; atypical.				multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			CTGATTCTACAAGCCCAGTTT	0.493			NA											9	54					0	0	0.006214	0	0
TUBB1	81027	broad.mit.edu	37	20	57599127	57599127	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:57599127G>A	uc002yak.2	+	4	914	c.645G>A	c.(643-645)CTG>CTA	p.L215L		NM_030773	NP_110400	Q9H4B7	TBB1_HUMAN	beta tubulin 1, class VI	215					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity			ovary(1)	1	all_lung(29;0.00711)		Colorectal(105;0.109)		Colchicine(DB01394)|Docetaxel(DB01248)|Paclitaxel(DB01229)|Vindesine(DB00309)	TCCGTACCCTGAAGCTGACGA	0.547			NA											12	114					0	0	0.003163	0	0
CDH4	1002	broad.mit.edu	37	20	60511823	60511823	+	Missense_Mutation	SNP	C	C	A	rs139936391		TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:60511823C>A	uc002ybn.1	+	16	2587	c.2573C>A	c.(2572-2574)ACG>AAG	p.T858K	CDH4_uc002ybp.1_Missense_Mutation_p.T784K|uc002ybr.1_5'Flank	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	858	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			AACGACCCCACGGCACCCCCC	0.637			NA											4	22					3.59834e-05	4.47562e-05	0.001168	1	0
LAMA5	3911	broad.mit.edu	37	20	60889909	60889909	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:60889909G>A	uc002ycq.2	-	60	8209	c.8142C>T	c.(8140-8142)GCC>GCT	p.A2714A		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2714	Domain II and I.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGCCAATGCTGGCGGACAGGG	0.672			NA											11	98					0	0	0.001368	0	0
COL9A3	1299	broad.mit.edu	37	20	61468561	61468561	+	Missense_Mutation	SNP	G	G	A	rs140377811	byFrequency	TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:61468561G>A	uc002ydm.2	+	30	1733	c.1730G>A	c.(1729-1731)CGA>CAA	p.R577Q	COL9A3_uc002ydn.2_Missense_Mutation_p.R71Q	NM_001853	NP_001844	Q14050	CO9A3_HUMAN	alpha 3 type IX collagen precursor	577	Triple-helical region 2 (COL2).				axon guidance	collagen type IX					0	Breast(26;5.68e-08)					CCTGGCGCTCGAGGACCCCCT	0.672			NA											9	77					0	0	0.004482	0	0
KCNQ2	3785	broad.mit.edu	37	20	62038676	62038676	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:62038676C>A	uc002yey.1	-	17	2117	c.1940G>T	c.(1939-1941)CGG>CTG	p.R647L	KCNQ2_uc002yez.1_Missense_Mutation_p.R616L|KCNQ2_uc002yfa.1_Missense_Mutation_p.R629L|KCNQ2_uc002yfb.1_Missense_Mutation_p.R619L	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	647	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	GATGCCCATCCGCTGCATGTA	0.642			NA											7	38					0.00448238	0.00490617	0.004482	1	0
C21orf91	54149	broad.mit.edu	37	21	19190600	19190600	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr21:19190600C>G	uc002yko.3	-	2	127	c.36G>C	c.(34-36)TTG>TTC	p.L12F	C21orf91_uc002ykq.3_Missense_Mutation_p.L12F|C21orf91_uc002ykp.3_Missense_Mutation_p.L12F	NM_001100420	NP_001093890	Q9NYK6	EURL_HUMAN	early undifferentiated retina and lens isoform	12										ovary(1)	1				Epithelial(23;8.76e-05)|all cancers(11;0.000422)|OV - Ovarian serous cystadenocarcinoma(11;0.0107)|Lung(58;0.0129)|COAD - Colon adenocarcinoma(22;0.0303)|LUSC - Lung squamous cell carcinoma(23;0.0381)|Colorectal(24;0.0929)		TGTCATCATTCAAATCAATGT	0.383			NA											7	104					0	0	0.00308	0	0
KRTAP22-1	337979	broad.mit.edu	37	21	31973475	31973475	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr21:31973475C>T	uc011add.1	+	1	36	c.36C>T	c.(34-36)GGC>GGT	p.G12G	KRTAP6-2_uc011adc.1_5'Flank	NM_181620	NP_853651	Q3MIV0	KR221_HUMAN	keratin associated protein 22-1	12						intermediate filament					0						GTGGCCAGGGCTATGCCAAAG	0.448			NA											10	166					0	0	0.008291	0	0
KRTAP6-1	337966	broad.mit.edu	37	21	31986066	31986066	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr21:31986066G>C	uc002yop.2	-	1	158	c.158C>G	c.(157-159)TCC>TGC	p.S53C	KRTAP20-1_uc011ade.1_5'Flank	NM_181602	NP_853633	Q3LI64	KRA61_HUMAN	keratin associated protein 6-1	53						cytosol|intermediate filament					0						GAGGGAGCGGGAGCCATAGCC	0.582			NA											11	120					0	0	0.000978	0	0
TIAM1	7074	broad.mit.edu	37	21	32492988	32492988	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr21:32492988G>A	uc002yow.1	-	29	4946	c.4474C>T	c.(4474-4476)CAG>TAG	p.Q1492*	TIAM1_uc011adk.1_3'UTR|TIAM1_uc011adl.1_Nonsense_Mutation_p.Q1432*	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1492					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TCCTCATACTGAGCAAGATCA	0.562			NA											7	49					0	0	0.001984	0	0
DOPEY2	9980	broad.mit.edu	37	21	37661499	37661499	+	Silent	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr21:37661499T>C	uc002yvg.2	+	35	6589	c.6510T>C	c.(6508-6510)TTT>TTC	p.F2170F	DOPEY2_uc011aeb.1_Silent_p.F2119F	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	2170					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						TGCCATTATTTCAAATGTAAG	0.383			NA											17	58					0	0	0.001882	0	0
DSCAM	1826	broad.mit.edu	37	21	41539175	41539175	+	Silent	SNP	T	T	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr21:41539175T>G	uc002yyq.1	-	16	3440	c.2988A>C	c.(2986-2988)ATA>ATC	p.I996I	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	996	Fibronectin type-III 2.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TCTGAGATGATATAGGCTCCA	0.522	Melanoma(134;970 1778 1785 21664 32388)		NA											6	72					0	0	0.00308	0	0
DSCAM	1826	broad.mit.edu	37	21	41684035	41684035	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr21:41684035C>A	uc002yyq.1	-	9	2487	c.2035G>T	c.(2035-2037)GAG>TAG	p.E679*	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	679	Extracellular (Potential).|Ig-like C2-type 7.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CTTTGGTGCTCCACAGCGGCG	0.478	Melanoma(134;970 1778 1785 21664 32388)		NA											7	116					2.17888e-05	2.74029e-05	0.006214	1	0
DSCAM	1826	broad.mit.edu	37	21	41725607	41725607	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr21:41725607T>A	uc002yyq.1	-	5	1171	c.719A>T	c.(718-720)CAG>CTG	p.Q240L	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	240	Extracellular (Potential).|Ig-like C2-type 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CTCCACACGCTGCCCAGCCAT	0.547	Melanoma(134;970 1778 1785 21664 32388)		NA											5	25					0	0	0.001168	0	0
DSCAM	1826	broad.mit.edu	37	21	42064747	42064747	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr21:42064747G>A	uc002yyq.1	-	3	949	c.497C>T	c.(496-498)TCA>TTA	p.S166L	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	166	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGAGACAAGTGAAACAGTGTC	0.502	Melanoma(134;970 1778 1785 21664 32388)		NA											12	81					0	0	0.001855	0	0
KRTAP10-5	386680	broad.mit.edu	37	21	46000336	46000336	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr21:46000336G>A	uc002zfl.1	-	1	146	c.120C>T	c.(118-120)GTC>GTT	p.V40V	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198694	NP_941967	P60370	KR105_HUMAN	keratin associated protein 10-5	40	22 X 5 AA repeats of C-C-X(3).					keratin filament					0						CTGGGGTGCAGACCAGGGTCA	0.632			NA											10	61					0	0	0.000978	0	0
COL6A2	1292	broad.mit.edu	37	21	47546018	47546018	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr21:47546018C>A	uc002zia.1	+	26	2371	c.2289C>A	c.(2287-2289)TTC>TTA	p.F763L	COL6A2_uc002zhy.1_Missense_Mutation_p.F763L|COL6A2_uc002zhz.1_Missense_Mutation_p.F763L|COL6A2_uc002zib.1_Missense_Mutation_p.F169L|COL6A2_uc002zic.1_5'Flank	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	763	VWFA 2.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		GGGACATGTTCCACGAGAAGC	0.622			NA											33	178					9.65021e-13	1.51287e-12	0.002096	1	0
BPIL2	254240	broad.mit.edu	37	22	32833771	32833771	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr22:32833771C>G	uc003amn.2	-	7	723	c.723G>C	c.(721-723)GAG>GAC	p.E241D	BPIL2_uc010gwo.2_Missense_Mutation_p.E55D|BPIL2_uc011amb.1_5'UTR	NM_174932	NP_777592	Q8NFQ6	BPIL2_HUMAN	bactericidal/permeability-increasing	241						extracellular region	lipopolysaccharide binding|phospholipid binding			ovary(1)|skin(1)	2						CAAGGTAGTTCTCAGTAATTT	0.343			NA											5	48					0	0	0.000602	0	0
HMGXB4	10042	broad.mit.edu	37	22	35661015	35661015	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr22:35661015C>T	uc003anl.2	+	5	808	c.634C>T	c.(634-636)CAA>TAA	p.Q212*	HMGXB4_uc011amh.1_Nonsense_Mutation_p.Q103*|HMGXB4_uc003ank.2_Nonsense_Mutation_p.Q103*	NM_001003681	NP_001003681	Q9UGU5	HMGX4_HUMAN	high-mobility group protein 2-like 1	212					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|skin(1)	2						GGAGTCTTTTCAATATCCCTC	0.453			NA											18	236					0	0	0.007413	0	0
XPNPEP3	63929	broad.mit.edu	37	22	41282319	41282319	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr22:41282319G>T	uc003azh.2	+	4	684	c.592G>T	c.(592-594)GAG>TAG	p.E198*	XPNPEP3_uc011aox.1_Nonsense_Mutation_p.E198*|XPNPEP3_uc003azi.2_Nonsense_Mutation_p.E119*|XPNPEP3_uc011aoy.1_RNA|XPNPEP3_uc010gyh.1_RNA	NM_022098	NP_071381	Q9NQH7	XPP3_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 3,	198					cellular process	mitochondrion	aminopeptidase activity|manganese ion binding|metallopeptidase activity				0						ATTCTAAGCTGAGACGAACAT	0.408	Ovarian(145;306 1841 7037 21878 30110)		NA											10	93					2.27111e-07	3.1406e-07	0.001368	1	0
POLR3H	171568	broad.mit.edu	37	22	41926752	41926752	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr22:41926752G>A	uc003baf.2	-	6	560	c.500C>T	c.(499-501)TCA>TTA	p.S167L	POLR3H_uc003bae.2_RNA|POLR3H_uc003bag.2_Missense_Mutation_p.S167L|POLR3H_uc003bai.2_Missense_Mutation_p.S138L	NM_138338	NP_612211	Q9Y535	RPC8_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	167					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			skin(1)	1						GGCATCTGCTGAGCTGGGCCC	0.617			NA											4	28					0	0	0.000602	0	0
MLC1	23209	broad.mit.edu	37	22	50523201	50523201	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr22:50523201G>A	uc003bjg.1	-	2	404	c.131C>T	c.(130-132)CCC>CTC	p.P44L	MLC1_uc011arl.1_Missense_Mutation_p.P44L|MLC1_uc003bjh.1_Missense_Mutation_p.P44L|MLC1_uc011arm.1_Missense_Mutation_p.P44L|MLC1_uc011arn.1_Intron|MLC1_uc011aro.1_Missense_Mutation_p.P44L	NM_139202	NP_631941	Q15049	MLC1_HUMAN	megalencephalic leukoencephalopathy with	44						basolateral plasma membrane|endosome|integral to membrane|integral to membrane of membrane fraction	ion channel activity			pancreas(1)	1		all_cancers(38;7.69e-11)|all_epithelial(38;9.52e-10)|all_lung(38;3.67e-05)|Breast(42;0.000776)|Lung NSC(38;0.000946)|Ovarian(80;0.0365)|Lung SC(80;0.113)		READ - Rectum adenocarcinoma(2;0.000669)|Colorectal(2;0.00242)|LUAD - Lung adenocarcinoma(64;0.0695)|BRCA - Breast invasive adenocarcinoma(115;0.216)		GAAGCAGGGGGGCAGTCTCTT	0.652			NA											3	58					0	0	0.004672	0	0
MOV10L1	54456	broad.mit.edu	37	22	50573048	50573048	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr22:50573048A>T	uc003bjj.2	+	15	2142	c.2059A>T	c.(2059-2061)ACC>TCC	p.T687S	MOV10L1_uc003bjk.3_Missense_Mutation_p.T687S|MOV10L1_uc011arp.1_Missense_Mutation_p.T667S|MOV10L1_uc011arq.1_Missense_Mutation_p.T448S|MOV10L1_uc010hao.1_RNA	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	687					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		TGGACAGTCCACCAGCAAAAA	0.478			NA											11	129					0	0	0.001368	0	0
PLXNB2	23654	broad.mit.edu	37	22	50724456	50724456	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr22:50724456G>T	uc003bkv.3	-	10	2055	c.1949C>A	c.(1948-1950)TCG>TAG	p.S650*		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	650	Extracellular (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AGGGTTGGGCGAAGCCTCCCG	0.682			NA											4	24					4.096e-09	5.95602e-09	0.001168	1	0
ARSA	410	broad.mit.edu	37	22	51065369	51065369	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr22:51065369G>C	uc003bnb.3	-	4	824	c.571C>G	c.(571-573)CCC>GCC	p.P191A	ARSA_uc003bna.3_Missense_Mutation_p.P107A|ARSA_uc003bnc.3_Missense_Mutation_p.P191A|ARSA_uc003bnd.3_Missense_Mutation_p.P191A|ARSA_uc003bmz.3_Missense_Mutation_p.P191A|ARSA_uc010hbf.2_3'UTR	NM_001085426	NP_001078895	P15289	ARSA_HUMAN	arylsulfatase A isoform a precursor	191			P -> T (in MLD; juvenile-onset).			lysosome	arylsulfatase activity|calcium ion binding|cerebroside-sulfatase activity			pancreas(1)|skin(1)	2		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)	Micafungin(DB01141)	AGCCAGGGGGGCTGCGCCTCC	0.672			NA											4	72					0	0	0.009096	0	0
CNTN6	27255	broad.mit.edu	37	3	1262497	1262497	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:1262497G>A	uc003boz.2	+	3	449	c.182G>A	c.(181-183)AGG>AAG	p.R61K	CNTN6_uc010hbo.2_Missense_Mutation_p.R56K|CNTN6_uc011asj.1_5'UTR|CNTN6_uc003bpa.2_Missense_Mutation_p.R61K	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	61	Ig-like C2-type 1.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		CCTCATTATAGGTAAAATCCT	0.299			NA											17	100					0	0	0.010504	0	0
GRM7	2917	broad.mit.edu	37	3	7340467	7340467	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:7340467C>G	uc003bqm.2	+	3	1107	c.833C>G	c.(832-834)CCC>CGC	p.P278R	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.P278R|GRM7_uc003bql.2_Missense_Mutation_p.P278R|GRM7_uc003bqn.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	278	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	CTGGACACCCCCAACTCCAGG	0.453			NA											6	45					0	0	0.001168	0	0
FANCD2	2177	broad.mit.edu	37	3	10105580	10105580	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:10105580G>T	uc003buw.2	+	21	2010	c.1932G>T	c.(1930-1932)CTG>CTT	p.L644L	FANCD2_uc003bux.1_Silent_p.L644L|FANCD2_uc003buy.1_Silent_p.L644L|FANCD2_uc010hcw.1_RNA	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	644					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		ATGAAAAGCTGGATCCAAAAG	0.433			NA	D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				5	108					1.26484e-09	1.86932e-09	0.00308	1	0
ATP2B2	491	broad.mit.edu	37	3	10370725	10370725	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:10370725C>T	uc003bvt.2	-	23	3944	c.3505G>A	c.(3505-3507)GCT>ACT	p.A1169T	ATP2B2_uc003bvv.2_Missense_Mutation_p.A1124T|ATP2B2_uc003bvw.2_Missense_Mutation_p.A1124T|ATP2B2_uc003bvs.2_RNA|ATP2B2_uc010hdo.2_Missense_Mutation_p.A874T|hsa-mir-378b|MI0014154_5'Flank	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	1169	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						TCAGGATGAGCCATGAAGTTA	0.532	Ovarian(125;1619 1709 15675 19819 38835)		NA											11	66					0	0	0.008291	0	0
ATP2B2	491	broad.mit.edu	37	3	10430011	10430011	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:10430011A>T	uc003bvt.2	-	6	1296	c.857T>A	c.(856-858)TTT>TAT	p.F286Y	ATP2B2_uc003bvv.2_Missense_Mutation_p.F286Y|ATP2B2_uc003bvw.2_Missense_Mutation_p.F286Y|ATP2B2_uc010hdp.2_Missense_Mutation_p.F286Y|ATP2B2_uc010hdo.2_Missense_Mutation_p.F22Y	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	286	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CAGGAGGGTAAAGATGATGCC	0.527	Ovarian(125;1619 1709 15675 19819 38835)		NA											37	201					0	0	0.00623	0	0
SLC6A11	6538	broad.mit.edu	37	3	10885924	10885924	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:10885924G>A	uc003bvz.2	+	5	683	c.649G>A	c.(649-651)GGG>AGG	p.G217R		NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	217	Extracellular (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		CATCTCTGACGGGATCGAGCA	0.592			NA											9	54					0	0	0.008291	0	0
CAND2	23066	broad.mit.edu	37	3	12858893	12858893	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:12858893G>A	uc003bxk.2	+	10	2511	c.2462G>A	c.(2461-2463)AGC>AAC	p.S821N	CAND2_uc003bxj.2_Missense_Mutation_p.S728N	NM_001162499	NP_001155971	O75155	CAND2_HUMAN	TBP-interacting protein isoform 1	821					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			skin(3)|pancreas(1)	4						GAGGCGGCAAGCACAGCCAGT	0.657	GBM(43;676 868 1633 6395 37496)		NA											5	60					0	0	0.000602	0	0
FGD5	152273	broad.mit.edu	37	3	14862391	14862391	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:14862391G>T	uc003bzc.2	+	1	1923	c.1813G>T	c.(1813-1815)GGC>TGC	p.G605C	FGD5_uc011avk.1_Missense_Mutation_p.G605C	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	605					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						TCCGTCCAGCGGCACCTCCAC	0.542			NA											9	55					3.86212e-05	4.77085e-05	0.008291	1	0
OXSM	54995	broad.mit.edu	37	3	25835776	25835776	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:25835776G>T	uc003cdn.2	+	3	1278	c.1171G>T	c.(1171-1173)GGG>TGG	p.G391W	OXSM_uc011awp.1_Missense_Mutation_p.G116W|OXSM_uc010hfh.2_Missense_Mutation_p.G308W	NM_017897	NP_060367	Q9NWU1	OXSM_HUMAN	3-oxoacyl-ACP synthase, mitochondrial isoform 1	391					acyl-CoA metabolic process|medium-chain fatty acid biosynthetic process|short-chain fatty acid biosynthetic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity			ovary(1)|breast(1)	2						GGGAGCTGCAGGGGCAGTCGA	0.433			NA											12	81					3.07112e-06	4.06035e-06	0.000978	1	0
EPM2AIP1	9852	broad.mit.edu	37	3	37034182	37034182	+	Silent	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:37034182C>G	uc003cgk.2	-	1	614	c.387G>C	c.(385-387)CTG>CTC	p.L129L	MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620	Q7L775	EPMIP_HUMAN	EPM2A interacting protein 1	129						endoplasmic reticulum					0						GTACCTCTCTCAGCAACACCT	0.577			NA											10	117					0	0	0.001368	0	0
SCN5A	6331	broad.mit.edu	37	3	38592196	38592196	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:38592196G>A	uc003cio.2	-	28	5861	c.5667C>T	c.(5665-5667)TAC>TAT	p.Y1889Y	SCN5A_uc003cin.2_Silent_p.Y1888Y|SCN5A_uc003cil.3_Silent_p.Y1889Y|SCN5A_uc010hhi.2_Silent_p.Y1871Y|SCN5A_uc010hhk.2_Silent_p.Y1856Y|SCN5A_uc011ayr.1_Silent_p.Y1835Y	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1889					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TGATGGGCTCGTAGGAGATCT	0.587			NA											19	129					0	0	0.00333	0	0
ZNF197	10168	broad.mit.edu	37	3	44671009	44671009	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:44671009G>C	uc003cnm.2	+	2	569	c.363G>C	c.(361-363)CAG>CAC	p.Q121H	ZNF197_uc003cnn.2_Missense_Mutation_p.Q121H|ZNF197_uc003cno.2_RNA|ZNF197_uc003cnp.2_Missense_Mutation_p.Q121H	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	121	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		AGGAGCTGCAGAAAGACCTTG	0.562			NA											3	26					0	0	0.009096	0	0
NBEAL2	23218	broad.mit.edu	37	3	47044463	47044463	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:47044463C>T	uc003cqp.2	+	34	5655	c.5476C>T	c.(5476-5478)CGC>TGC	p.R1826C	NBEAL2_uc010hjm.1_Missense_Mutation_p.R1203C|NBEAL2_uc010hjn.1_Missense_Mutation_p.R222C|NBEAL2_uc010hjo.1_5'Flank	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1826							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TCCCATCCCCCGCTGGAAACT	0.612			NA											4	18					0	0	0.000602	0	0
SETD2	29072	broad.mit.edu	37	3	47161676	47161676	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:47161676C>A	uc003cqs.2	-	3	4503	c.4450G>T	c.(4450-4452)GAA>TAA	p.E1484*	SETD2_uc003cqv.2_Nonsense_Mutation_p.E1473*	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1484					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		ACTTACCTTTCTGTTAAATAA	0.328			NA	N|F|S|Mis		clear cell renal carcinoma								15	75					3.41278e-10	5.11068e-10	0.00499	1	0
PFKFB4	5210	broad.mit.edu	37	3	48575973	48575973	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:48575973C>A	uc003ctv.2	-	7	607	c.590G>T	c.(589-591)TGC>TTC	p.C197F	PFKFB4_uc003ctw.2_Missense_Mutation_p.C6F|PFKFB4_uc010hkc.2_Missense_Mutation_p.C197F|PFKFB4_uc003ctx.2_Missense_Mutation_p.C154F|PFKFB4_uc010hkb.2_Missense_Mutation_p.C197F|PFKFB4_uc011bbm.1_Missense_Mutation_p.C186F|PFKFB4_uc011bbn.1_RNA	NM_004567	NP_004558	Q16877	F264_HUMAN	6-phosphofructo-2-kinase/fructose-2,	197	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0003)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		GTTCTCATAGCACTCAATGCG	0.592			NA											8	40					0.00307968	0.00339969	0.00308	1	0
BSN	8927	broad.mit.edu	37	3	49698291	49698291	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:49698291C>G	uc003cxe.3	+	6	9127	c.9013C>G	c.(9013-9015)CTT>GTT	p.L3005V		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3005					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CTTGCGTGGTCTTGGCGAGCA	0.592			NA											6	20					0	0	0.001984	0	0
RNF123	63891	broad.mit.edu	37	3	49735535	49735535	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:49735535G>T	uc003cxh.2	+	7	534	c.448G>T	c.(448-450)GGC>TGC	p.G150C	RNF123_uc010hky.1_5'Flank|RNF123_uc003cxi.2_5'Flank	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	150	B30.2/SPRY.					cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		CATGCAGATCGGCTGGTGCAC	0.617			NA											14	71					1.5842e-08	2.24927e-08	0.001855	1	0
CADPS	8618	broad.mit.edu	37	3	62751604	62751604	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:62751604C>A	uc003dll.2	-	2	857	c.497G>T	c.(496-498)GGG>GTG	p.G166V	CADPS_uc003dlm.2_Missense_Mutation_p.G166V|CADPS_uc003dln.2_Missense_Mutation_p.G166V	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	166					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CTGGGTTTCCCCATTGAGGAA	0.473			NA											22	102					4.72057e-08	6.65004e-08	0.003954	1	0
PDZRN3	23024	broad.mit.edu	37	3	73433185	73433185	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:73433185G>T	uc003dpl.1	-	10	2628	c.2532C>A	c.(2530-2532)GAC>GAA	p.D844E	PDZRN3_uc011bgh.1_Missense_Mutation_p.D501E|PDZRN3_uc010hoe.1_Missense_Mutation_p.D542E|PDZRN3_uc011bgf.1_Missense_Mutation_p.D561E|PDZRN3_uc011bgg.1_Missense_Mutation_p.D564E	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	844							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TCCGGCTCCCGTCGCTGGCTC	0.667			NA											10	40					0.000978159	0.00111244	0.000978	1	0
ROBO2	6092	broad.mit.edu	37	3	77147352	77147352	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:77147352G>T	uc003dpy.3	+	2	892	c.249G>T	c.(247-249)ATG>ATT	p.M83I	ROBO2_uc003dpz.2_Missense_Mutation_p.M83I|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.M83I	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	83	Ig-like C2-type 1.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CCCACAGGATGCTTCTGCCCA	0.567			NA											13	40					1.52009e-12	2.36662e-12	0.003163	1	0
ROBO1	6091	broad.mit.edu	37	3	78663903	78663903	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:78663903C>G	uc003dqe.2	-	28	4538	c.4330G>C	c.(4330-4332)GTG>CTG	p.V1444L	ROBO1_uc003dqb.2_Missense_Mutation_p.V1405L|ROBO1_uc003dqc.2_Missense_Mutation_p.V1344L|ROBO1_uc003dqd.2_Missense_Mutation_p.V1399L|ROBO1_uc010hoh.2_Missense_Mutation_p.V636L|ROBO1_uc011bgl.1_Missense_Mutation_p.V1016L	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1444	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TCTGTAGACACGGGACTTGTG	0.468			NA											3	29					0	0	0.004672	0	0
CADM2	253559	broad.mit.edu	37	3	85932560	85932560	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:85932560G>T	uc003dqj.2	+	3	957	c.331G>T	c.(331-333)GTC>TTC	p.V111F	CADM2_uc003dqk.2_Missense_Mutation_p.V120F|CADM2_uc003dql.2_Missense_Mutation_p.V113F	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	111	Ig-like V-type.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		TACAATGCCTGTCAAAACTTC	0.423			NA											6	43					0.00116845	0.00131559	0.001168	1	0
VGLL3	389136	broad.mit.edu	37	3	87018166	87018166	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:87018166G>A	uc003dqn.2	-	3	875	c.511C>T	c.(511-513)CAG>TAG	p.Q171*		NM_016206	NP_057290	A8MV65	VGLL3_HUMAN	colon carcinoma related protein	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		CCAGTGACCTGGAAGTCAGGA	0.592			NA											7	88					0	0	0.00308	0	0
ARL13B	200894	broad.mit.edu	37	3	93761927	93761927	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:93761927G>A	uc003drc.2	+	7	1153	c.867G>A	c.(865-867)CTG>CTA	p.L289L	ARL13B_uc010hop.2_Silent_p.L140L|ARL13B_uc003drd.2_Silent_p.L182L|ARL13B_uc003dre.2_Silent_p.L274L|ARL13B_uc003drf.2_Silent_p.L289L|ARL13B_uc003drg.2_Silent_p.L186L	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1	289							GTP binding				0						GCTGCCACCTGAAACATAAAA	0.323			NA											6	24					0	0	0.001984	0	0
EPHA6	285220	broad.mit.edu	37	3	97167434	97167434	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:97167434C>A	uc010how.1	+	7	1797	c.1754C>A	c.(1753-1755)TCT>TAT	p.S585Y	EPHA6_uc011bgo.1_RNA|EPHA6_uc011bgp.1_5'UTR|EPHA6_uc003drs.3_5'UTR|EPHA6_uc003drr.3_5'UTR|EPHA6_uc003drt.2_5'UTR|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	490	Fibronectin type-III 2.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CTGACCTACTCTTCCACAAGG	0.438			NA											10	78					1.58986e-06	2.13004e-06	0.008291	1	0
EPHA6	285220	broad.mit.edu	37	3	97167456	97167456	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:97167456C>A	uc010how.1	+	7	1819	c.1776C>A	c.(1774-1776)CCC>CCA	p.P592P	EPHA6_uc011bgo.1_RNA|EPHA6_uc011bgp.1_5'UTR|EPHA6_uc003drs.3_5'UTR|EPHA6_uc003drr.3_5'UTR|EPHA6_uc003drt.2_5'UTR|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	497	Fibronectin type-III 2.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CCAAAGCCCCCAGTGTCATCA	0.448			NA											10	79					4.68919e-08	6.61615e-08	0.008291	1	0
DPPA4	55211	broad.mit.edu	37	3	109050827	109050827	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:109050827T>A	uc003dxq.3	-	3	285	c.230A>T	c.(229-231)AAG>ATG	p.K77M	DPPA4_uc011bho.1_Missense_Mutation_p.K77M|DPPA4_uc011bhp.1_Missense_Mutation_p.K77M	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	77						nucleus	protein binding			upper_aerodigestive_tract(1)	1						TGGTATCTTCTTCTGAGGTCT	0.463			NA											38	159					0	0	0.002852	0	0
WDR52	55779	broad.mit.edu	37	3	113128135	113128135	+	Silent	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:113128135A>G	uc003eae.1	-	7	754	c.708T>C	c.(706-708)TTT>TTC	p.F236F		NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	236	WD 1.									central_nervous_system(1)	1						CGCTGTAGTTAAAGTCCACAT	0.388			NA											15	76					0	0	0.00245	0	0
DRD3	1814	broad.mit.edu	37	3	113850108	113850108	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:113850108G>T	uc003ebd.2	-	7	1286	c.863C>A	c.(862-864)CCC>CAC	p.P288H	DRD3_uc010hqn.1_Missense_Mutation_p.P288H|DRD3_uc003ebb.1_Intron|DRD3_uc003ebc.1_Missense_Mutation_p.P288H	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	288	Cytoplasmic.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	CGCTATGGTGGGACTCAGGGA	0.532			NA											27	206					1.39806e-14	2.25436e-14	0.008361	1	0
ARGFX	503582	broad.mit.edu	37	3	121305010	121305010	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:121305010G>A	uc003eef.2	+	5	606	c.511G>A	c.(511-513)GTG>ATG	p.V171M		NM_001012659	NP_001012677	A6NJG6	ARGFX_HUMAN	arginine-fifty homeobox	171						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(114;0.152)		TTTTTCTCCTGTGATTTCAGA	0.493			NA											22	144					0	0	0.00278	0	0
HCLS1	3059	broad.mit.edu	37	3	121351227	121351227	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:121351227C>T	uc003eeh.3	-	12	1317	c.1192G>A	c.(1192-1194)GAG>AAG	p.E398K	HCLS1_uc011bjj.1_Missense_Mutation_p.E361K|HCLS1_uc011bjk.1_RNA	NM_005335	NP_005326	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	398					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(114;0.0912)		AGCACCTCCTCATAGTCCCCC	0.433			NA											35	247					0	0	0.00623	0	0
ADCY5	111	broad.mit.edu	37	3	123049786	123049786	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:123049786G>T	uc003egh.1	-	5	1596	c.1596C>A	c.(1594-1596)GAC>GAA	p.D532E	ADCY5_uc003egg.1_Missense_Mutation_p.D165E|ADCY5_uc003egi.1_Missense_Mutation_p.D91E	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	532	Guanylate cyclase 1.|Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		AGTGGGCGTGGTCAGCCCTTG	0.532			NA											5	45					5.9392e-07	8.11361e-07	0.001168	1	0
CCDC37	348807	broad.mit.edu	37	3	126152008	126152008	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:126152008C>A	uc003eiu.1	+	14	1482	c.1383C>A	c.(1381-1383)GCC>GCA	p.A461A	CCDC37_uc010hsg.1_Silent_p.A462A	NM_182628	NP_872434	Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	461										ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.166)		AGCTCAAAGCCCGAGTCTTCC	0.602			NA											13	104					0.00185496	0.0020782	0.001855	1	0
PLXND1	23129	broad.mit.edu	37	3	129284183	129284183	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:129284183C>A	uc003emx.2	-	25	4621	c.4521G>T	c.(4519-4521)CGG>CGT	p.R1507R	PLXND1_uc011blb.1_Silent_p.R175R	NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1507	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						GCAGCCTCACCCGCAGACAGC	0.657	Ovarian(97;366 1484 3738 22084 39045)		NA											6	45					5.9392e-07	8.11361e-07	0.001168	1	0
TRPC1	7220	broad.mit.edu	37	3	142524944	142524944	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:142524944T>C	uc003evc.2	+	13	2385	c.2249T>C	c.(2248-2250)ATG>ACG	p.M750T	TRPC1_uc003evb.2_Missense_Mutation_p.M716T	NM_003304	NP_003295	P48995	TRPC1_HUMAN	transient receptor potential cation channel,	750					axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						AGACAGAAGATGCAAAGTACA	0.398			NA											9	57					0	0	0.004482	0	0
HLTF	6596	broad.mit.edu	37	3	148791111	148791111	+	Splice_Site	SNP	T	T	C	rs138362499		TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:148791111T>C	uc003ewq.1	-	5	748	c.530_splice	c.e5-1	p.T177_splice	HLTF_uc003ewr.1_Splice_Site_p.T177_splice|HLTF_uc003ews.1_Splice_Site_p.T177_splice|HLTF_uc010hve.1_Splice_Site_p.T177_splice	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor						chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			ATCCTAAAGCTATAATTTACA	0.323			NA											8	51					0	0	0.00308	0	0
SHOX2	6474	broad.mit.edu	37	3	157820469	157820469	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:157820469G>A	uc003fbr.2	-	2	692	c.553C>T	c.(553-555)CAG>TAG	p.Q185*	SHOX2_uc003fbs.2_Nonsense_Mutation_p.Q209*|SHOX2_uc010hvw.2_Nonsense_Mutation_p.Q185*	NM_006884	NP_006875	O60902	SHOX2_HUMAN	short stature homeobox 2 isoform a	185	Homeobox.				nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			CTGGGTACCTGCACTCGGGCC	0.622			NA											6	54					0	0	0.001168	0	0
ZBBX	79740	broad.mit.edu	37	3	167016162	167016162	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:167016162C>A	uc003fep.2	-	18	2133	c.1810G>T	c.(1810-1812)GAA>TAA	p.E604*	ZBBX_uc011bpc.1_Nonsense_Mutation_p.E604*|ZBBX_uc003feq.2_Nonsense_Mutation_p.E575*	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	604						intracellular	zinc ion binding			ovary(2)	2						TTGAGTCTTTCATTTGTATCA	0.313			NA											12	43					0.000978159	0.00111244	0.000978	1	0
GOLIM4	27333	broad.mit.edu	37	3	167761305	167761305	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:167761305C>G	uc003ffe.2	-	5	723	c.379G>C	c.(379-381)GAG>CAG	p.E127Q	GOLIM4_uc011bpe.1_Missense_Mutation_p.E127Q|GOLIM4_uc011bpf.1_Missense_Mutation_p.E127Q|GOLIM4_uc011bpg.1_Missense_Mutation_p.E127Q	NM_014498	NP_055313	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	127	Endosome targeting.|Potential.|Lumenal (Potential).				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5						TTCTTTAGCTCCTCGTGTTGG	0.368			NA											19	110					0	0	0.010504	0	0
PLD1	5337	broad.mit.edu	37	3	171395355	171395355	+	Splice_Site	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:171395355C>T	uc003fhs.2	-	17	2112	c.1996_splice	c.e17+1	p.D666_splice	PLD1_uc003fht.2_Splice_Site_p.D628_splice|PLD1_uc003fhu.3_5'Flank|PLD1_uc003fhv.1_Intron	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a						cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	ATGATACTCACCAGCAAAAGG	0.418	NSCLC(149;2174 3517 34058)		NA											17	143					0	0	0.002299	0	0
NLGN1	22871	broad.mit.edu	37	3	173998675	173998675	+	Nonsense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:173998675C>G	uc003fio.1	+	7	2477	c.2054C>G	c.(2053-2055)TCA>TGA	p.S685*	NLGN1_uc003fip.1_Nonsense_Mutation_p.S685*	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	702	Helical; (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			GTTGGAGCATCACTGCTGTTT	0.473			NA											12	60					0	0	0.001368	0	0
MFN1	55669	broad.mit.edu	37	3	179104264	179104264	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:179104264C>T	uc003fjs.2	+	16	1985	c.1859C>T	c.(1858-1860)ACT>ATT	p.T620I	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Missense_Mutation_p.T648I|MFN1_uc010hxc.2_Missense_Mutation_p.T362I	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	620	Helical; Name=2; (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			GTTTCATTAACTATGTATGGA	0.388			NA											10	79					0	0	0.006214	0	0
MFN1	55669	broad.mit.edu	37	3	179104270	179104270	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:179104270A>G	uc003fjs.2	+	16	1991	c.1865A>G	c.(1864-1866)TAT>TGT	p.Y622C	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Missense_Mutation_p.Y650C|MFN1_uc010hxc.2_Missense_Mutation_p.Y364C	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	622	Helical; Name=2; (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			TTAACTATGTATGGAGCTTTG	0.393			NA											11	79					0	0	0.008291	0	0
PEX5L	51555	broad.mit.edu	37	3	179605481	179605481	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:179605481G>T	uc003fki.1	-	4	420	c.290C>A	c.(289-291)CCA>CAA	p.P97Q	PEX5L_uc011bqd.1_Missense_Mutation_p.P54Q|PEX5L_uc011bqe.1_5'UTR|PEX5L_uc011bqf.1_Missense_Mutation_p.P54Q|PEX5L_uc003fkj.1_Missense_Mutation_p.P62Q|PEX5L_uc010hxd.1_Missense_Mutation_p.P95Q|PEX5L_uc011bqg.1_Missense_Mutation_p.P73Q|PEX5L_uc011bqh.1_Missense_Mutation_p.P38Q	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	97					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			GGATGTTACTGGCCTTGCTAT	0.393			NA											32	181					7.16026e-08	9.99338e-08	0.002445	1	0
TTC14	151613	broad.mit.edu	37	3	180322022	180322022	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:180322022C>T	uc003fkk.2	+	4	628	c.496C>T	c.(496-498)CCC>TCC	p.P166S	TTC14_uc003fkl.2_Missense_Mutation_p.P166S|TTC14_uc003fkm.2_Missense_Mutation_p.P166S	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	166	S1 motif.						RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			GGCTCTTTGTCCCTTAAGAGA	0.358			NA											10	75					0	0	0.008291	0	0
FXR1	8087	broad.mit.edu	37	3	180667013	180667013	+	Splice_Site	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:180667013A>T	uc003fkq.2	+	7	536	c.514_splice	c.e7-2	p.S172_splice	FXR1_uc003fkp.2_Splice_Site_p.S87_splice|FXR1_uc003fkr.2_Splice_Site_p.S172_splice|FXR1_uc011bqj.1_Splice_Site_p.S86_splice|FXR1_uc003fks.2_Splice_Site_p.S86_splice|FXR1_uc011bqk.1_Splice_Site_p.S123_splice|FXR1_uc011bql.1_Splice_Site_p.S159_splice	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1						apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			GTTTGTTTATAGTCTGCCAGT	0.378			NA											21	154					0	0	0.002299	0	0
VPS8	23355	broad.mit.edu	37	3	184648287	184648287	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:184648287C>G	uc003fpb.1	+	33	2994	c.2823C>G	c.(2821-2823)ATC>ATG	p.I941M	VPS8_uc010hyd.1_Missense_Mutation_p.I851M|VPS8_uc010hye.1_Missense_Mutation_p.I370M	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	943							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			TTCACAATATCTTATCCATTC	0.398			NA											16	59					0	0	0.006122	0	0
SDHAP2	727956	broad.mit.edu	37	3	195400791	195400791	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr3:195400791A>T	uc003fuw.2	+	9	1281	c.87A>T	c.(85-87)CAA>CAT	p.Q29H	SDHAP2_uc011btb.1_Missense_Mutation_p.N177Y|SDHAP2_uc011btc.1_RNA|SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						CCTCGGGGCAAACTCGCTGTT	0.597			NA											5	27					0	0	0.000602	0	0
FGFRL1	53834	broad.mit.edu	37	4	1018200	1018200	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:1018200G>T	uc003gce.2	+	6	981	c.820G>T	c.(820-822)GTG>TTG	p.V274L	FGFRL1_uc003gcf.2_Missense_Mutation_p.V274L|FGFRL1_uc003gcg.2_Missense_Mutation_p.V274L|FGFRL1_uc010ibo.2_Missense_Mutation_p.V274L	NM_021923	NP_068742	Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	274	Ig-like C2-type 3.|Extracellular (Potential).				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GCGCAGCGACGTGAAGCCGGT	0.667			NA											11	32					1.5842e-08	2.24927e-08	0.001855	1	0
HTT	3064	broad.mit.edu	37	4	3137637	3137637	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:3137637G>T	uc011bvq.1	+	21	2791	c.2646G>T	c.(2644-2646)GTG>GTT	p.V882V		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	880					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		TTAGGCTGGTGAGCTTTTTGG	0.428			NA											10	88					7.48243e-07	1.00996e-06	0.006214	1	0
SLC34A2	10568	broad.mit.edu	37	4	25669550	25669550	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:25669550G>C	uc003grr.2	+	6	653	c.572G>C	c.(571-573)GGA>GCA	p.G191A	SLC34A2_uc003grs.2_Missense_Mutation_p.G190A|SLC34A2_uc010iev.2_Missense_Mutation_p.G190A	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	191	Cytoplasmic (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				GCCAACATTGGAACGTCAATC	0.512			NA											4	35					0	0	0.009096	0	0
GABRG1	2565	broad.mit.edu	37	4	46053639	46053639	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:46053639C>A	uc003gxb.2	-	8	1085	c.933G>T	c.(931-933)CTG>CTT	p.L311L		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	311	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TTGTCATAGTCAGAACTGTAG	0.353			NA											4	37					1.23904e-05	1.57585e-05	0.000602	1	0
FRYL	285527	broad.mit.edu	37	4	48553511	48553511	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:48553511C>T	uc003gyh.1	-	37	5125	c.4520G>A	c.(4519-4521)AGC>AAC	p.S1507N	FRYL_uc003gyk.2_Missense_Mutation_p.S1507N|FRYL_uc003gyg.1_Missense_Mutation_p.S203N|FRYL_uc003gyi.1_Missense_Mutation_p.S396N	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1507					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						AAGTACTTACCTCTCTTCAAT	0.368			NA											14	57					0	0	0.00245	0	0
LPHN3	23284	broad.mit.edu	37	4	62812636	62812636	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:62812636G>T	uc010ihh.2	+	13	2393	c.2220G>T	c.(2218-2220)GAG>GAT	p.E740D	LPHN3_uc003hcq.3_Missense_Mutation_p.E740D|LPHN3_uc003hct.2_Missense_Mutation_p.E133D	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	727	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						CTTTAGGAGAGATCAGAGTGG	0.363			NA											20	140					1.2644e-06	1.69904e-06	0.010504	1	0
EPHA5	2044	broad.mit.edu	37	4	66356384	66356384	+	Silent	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:66356384A>G	uc003hcy.2	-	5	1306	c.1113T>C	c.(1111-1113)ACT>ACC	p.T371T	EPHA5_uc003hcx.2_Silent_p.T302T|EPHA5_uc003hcz.2_Silent_p.T371T|EPHA5_uc011cah.1_Silent_p.T371T|EPHA5_uc011cai.1_Silent_p.T371T|EPHA5_uc003hda.2_Silent_p.T371T	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	371	Fibronectin type-III 1.|Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						GAAAGACACTAGTTTCATTAA	0.418			NA								TSP Lung(17;0.13)			4	48					0	0	0.009096	0	0
STAP1	26228	broad.mit.edu	37	4	68449311	68449311	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:68449311C>G	uc003hde.3	+	6	632	c.550C>G	c.(550-552)CGG>GGG	p.R184G	STAP1_uc003hdf.2_Missense_Mutation_p.R184G	NM_012108	NP_036240	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1	184	SH2.				cellular membrane fusion|intracellular protein transport	cytoplasm					0						TACAGTGTCCCGGAAAGAGGC	0.373			NA											5	31					0	0	0.001984	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68810272	68810272	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:68810272G>T	uc003hdr.1	-	3	338	c.217C>A	c.(217-219)CAA>AAA	p.Q73K	LOC550112_uc003hdl.3_Intron|TMPRSS11A_uc003hds.1_Missense_Mutation_p.Q73K	NM_182606	NP_872412	Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A isoform 1	73	SEA.|Extracellular (Potential).				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			skin(1)	1						TCCTTAAGTTGATATGTGTTG	0.343	NSCLC(26;2 894 10941 14480 22546)		NA											9	96					0.00621372	0.00673588	0.006214	1	0
SLC4A4	8671	broad.mit.edu	37	4	72121090	72121090	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:72121090C>T	uc003hfy.2	+	3	344	c.227C>T	c.(226-228)TCC>TTC	p.S76F	SLC4A4_uc010iic.2_Missense_Mutation_p.S76F|SLC4A4_uc010iib.2_Missense_Mutation_p.S76F|SLC4A4_uc003hfz.2_Missense_Mutation_p.S76F|SLC4A4_uc003hga.2_5'UTR	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	76	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			GCTGATGAATCCAGCAGCAGC	0.443			NA											16	121					0	0	0.004007	0	0
SLC4A4	8671	broad.mit.edu	37	4	72121092	72121092	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:72121092A>T	uc003hfy.2	+	3	346	c.229A>T	c.(229-231)AGC>TGC	p.S77C	SLC4A4_uc010iic.2_Missense_Mutation_p.S77C|SLC4A4_uc010iib.2_Missense_Mutation_p.S77C|SLC4A4_uc003hfz.2_Missense_Mutation_p.S77C|SLC4A4_uc003hga.2_5'UTR	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	77	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			TGATGAATCCAGCAGCAGCAT	0.438			NA											15	122					0	0	0.003163	0	0
NPFFR2	10886	broad.mit.edu	37	4	73012886	73012886	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:73012886G>A	uc003hgg.2	+	4	1024	c.926G>A	c.(925-927)CGG>CAG	p.R309Q	NPFFR2_uc010iig.1_Missense_Mutation_p.R91Q|NPFFR2_uc003hgi.2_Missense_Mutation_p.R210Q|NPFFR2_uc003hgh.2_Missense_Mutation_p.R207Q|NPFFR2_uc003hgj.2_RNA	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	309	Extracellular (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TACTGGTGCCGGGAAGACTGG	0.453			NA											7	54					0	0	0.001984	0	0
SDAD1	55153	broad.mit.edu	37	4	76885364	76885364	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:76885364T>A	uc003hje.3	-	14	1224	c.1105A>T	c.(1105-1107)ATT>TTT	p.I369F	SDAD1_uc003hjf.3_Missense_Mutation_p.I272F|SDAD1_uc011cbr.1_Missense_Mutation_p.I332F	NM_018115	NP_060585	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	369					protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GATTGAATAATCTGAATTGGA	0.368			NA											9	54					0	0	0.004482	0	0
ART3	419	broad.mit.edu	37	4	77022153	77022153	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:77022153C>G	uc003hjo.2	+	8	1037	c.918C>G	c.(916-918)AAC>AAG	p.N306K	ART3_uc003hjk.2_Missense_Mutation_p.N306K|ART3_uc003hjn.2_Missense_Mutation_p.N306K|ART3_uc003hjp.2_RNA|ART3_uc010ijb.2_RNA|ART3_uc003hjq.2_RNA|ART3_uc003hjr.2_Missense_Mutation_p.N276K|ART3_uc010ijc.2_Missense_Mutation_p.N265K|ART3_uc010ijd.2_Missense_Mutation_p.N276K	NM_001130016	NP_001123488	Q13508	NAR3_HUMAN	ADP-ribosyltransferase 3 isoform a	306	3.|3 X 10 AA tandem repeats of [GS]-E-K-N- [QW]-K-L-E-D-H.				protein ADP-ribosylation	anchored to membrane|integral to plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			ovary(2)	2			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GTGAGAAAAACCAGAAGCTTG	0.348			NA											5	123					0	0	0.001984	0	0
ANKRD56	345079	broad.mit.edu	37	4	77817765	77817765	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:77817765T>A	uc003hki.2	-	1	1238	c.1238A>T	c.(1237-1239)AAA>ATA	p.K413I		NM_001029870	NP_001025041	A6NEL2	ANR56_HUMAN	ankyrin repeat domain 56	413											0						CGGGGAGTCTTTGGGCCCACT	0.577			NA											10	67					0	0	0.006214	0	0
ENOPH1	58478	broad.mit.edu	37	4	83381180	83381180	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:83381180G>A	uc003hmv.2	+	6	950	c.693G>A	c.(691-693)GTG>GTA	p.V231V	ENOPH1_uc003hmw.2_Silent_p.V143V|ENOPH1_uc003hmx.2_Silent_p.V85V	NM_021204	NP_067027	Q9UHY7	ENOPH_HUMAN	enolase-phosphatase 1	231					L-methionine salvage from methylthioadenosine	cytoplasm|nucleus	2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity|2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity|acireductone synthase activity|magnesium ion binding|phosphoglycolate phosphatase activity				0						CTGTGGTGGTGAGACCAGGCA	0.453			NA											6	49					0	0	0.001168	0	0
HPGDS	27306	broad.mit.edu	37	4	95239050	95239050	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:95239050A>T	uc003hte.1	-	3	291	c.200T>A	c.(199-201)ATA>AAA	p.I67K		NM_014485	NP_055300	O60760	HPGDS_HUMAN	prostaglandin D2 synthase, hematopoietic	67	GST N-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity			ovary(1)	1					Glutathione(DB00143)	ATATCTTGCTATTGCTAGGCT	0.299	Colon(86;1802 1843 17863 46794)		NA											5	51					0	0	0.001168	0	0
LEF1	51176	broad.mit.edu	37	4	109086290	109086290	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:109086290C>G	uc003hyt.1	-	2	898	c.243G>C	c.(241-243)GAG>GAC	p.E81D	LEF1_uc011cfj.1_5'UTR|LEF1_uc011cfk.1_Missense_Mutation_p.E13D|LEF1_uc003hyu.1_Missense_Mutation_p.E81D|LEF1_uc003hyv.1_Missense_Mutation_p.E81D|LEF1_uc010imb.1_RNA	NM_016269	NP_057353	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1 isoform 1	81	Pro-rich.				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			large_intestine(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		CGTGGTAGGGCTCCTGAGAGG	0.443			NA											6	90					0	0	0.001984	0	0
LEF1	51176	broad.mit.edu	37	4	109088893	109088893	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:109088893C>T	uc003hyt.1	-	1	686	c.31G>A	c.(31-33)GGC>AGC	p.G11S	LEF1_uc011cfj.1_5'Flank|LEF1_uc011cfk.1_5'Flank|LEF1_uc003hyu.1_Missense_Mutation_p.G11S|LEF1_uc003hyv.1_Missense_Mutation_p.G11S|LEF1_uc010imb.1_RNA	NM_016269	NP_057353	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1 isoform 1	11	Poly-Gly.|CTNNB1-binding (By similarity).				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			large_intestine(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		TCCCCCCCGCCGCCGCCACCT	0.637			NA											11	112					0	0	0.000978	0	0
COL25A1	84570	broad.mit.edu	37	4	109745371	109745371	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:109745371G>T	uc003hze.1	-	34	2335	c.1804C>A	c.(1804-1806)CCA>ACA	p.P602T	COL25A1_uc003hzg.2_Missense_Mutation_p.P602T|COL25A1_uc003hzd.2_RNA|COL25A1_uc003hzf.2_Missense_Mutation_p.P390T	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	602	Extracellular (Potential).|Collagen-like 7.					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		TCACCCCGTGGACCAGGGAAG	0.408			NA											5	55					2.0095e-06	2.67637e-06	0.001984	1	0
GAR1	54433	broad.mit.edu	37	4	110743587	110743587	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:110743587G>T	uc003hzt.2	+	5	821	c.514G>T	c.(514-516)GGC>TGC	p.G172C	GAR1_uc003hzu.2_Missense_Mutation_p.G172C|GAR1_uc010imi.2_Missense_Mutation_p.G172C	NM_018983	NP_061856	Q9NY12	GAR1_HUMAN	nucleolar protein family A, member 1	172	RGG-box 2.				rRNA processing|snRNA pseudouridine synthesis	box H/ACA snoRNP complex|Cajal body	cation channel activity|pseudouridine synthase activity|snoRNA binding				0						aagaggtggtggcaggggagg	0.259			NA											6	46					3.59834e-05	4.47562e-05	0.001168	1	0
EGF	1950	broad.mit.edu	37	4	110915979	110915979	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:110915979A>G	uc003hzy.3	+	20	3400	c.2948A>G	c.(2947-2949)TAC>TGC	p.Y983C	EGF_uc011cfu.1_Missense_Mutation_p.Y941C|EGF_uc011cfv.1_Missense_Mutation_p.Y942C|EGF_uc010imk.2_Missense_Mutation_p.Y131C	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	983	EGF-like 9.|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	CACGATGGGTACTGCCTCCAT	0.463			NA											10	65					0	0	0.000978	0	0
FAT4	79633	broad.mit.edu	37	4	126373662	126373662	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:126373662G>T	uc003ifj.3	+	9	11491	c.11491G>T	c.(11491-11493)GAG>TAG	p.E3831*	FAT4_uc011cgp.1_Nonsense_Mutation_p.E2129*|FAT4_uc003ifi.1_Nonsense_Mutation_p.E1309*	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3831	Extracellular (Potential).|EGF-like 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AAAAAGCCGTGAGAGTCTTCC	0.488			NA											6	42					2.0095e-06	2.67637e-06	0.001984	1	0
PCDH10	57575	broad.mit.edu	37	4	134072243	134072244	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:134072243_134072244GG>TT	uc003iha.2	+	1	1774_1775	c.948_949GG>TT	c.(946-951)TTGGAC>TTTTAC	p.316_317LD>FY	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.316_317LD>FY	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	316_317	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GCGGCGAGTTGGACTATGAAGA	0.619			NA											8	54					0	0	0.004672	0	0
PCDH10	57575	broad.mit.edu	37	4	134084318	134084318	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:134084318G>T	uc003iha.2	+	4	3810	c.2984G>T	c.(2983-2985)GGG>GTG	p.G995V		NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	995	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GCCCAGCCTGGGGCAGAGCGG	0.557			NA											23	114					6.21321e-17	1.01456e-16	0.00278	1	0
FGB	2244	broad.mit.edu	37	4	155487824	155487824	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:155487824G>T	uc003ioa.3	+	3	529	c.490G>T	c.(490-492)GAT>TAT	p.D164Y	FGB_uc010ipu.1_RNA|FGB_uc003iob.3_Missense_Mutation_p.D161Y|FGB_uc010ipv.2_Missense_Mutation_p.D102Y|FGB_uc010ipw.2_Missense_Mutation_p.D161Y|FGB_uc003ioc.3_Intron	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	164	Potential.	Cleavage; by plasmin; to break down fibrin clots.			platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	GCAAGTAAAAGGTAGATATCC	0.408	NSCLC(106;1133 1613 21870 46110 52656)		NA											13	72					9.31168e-06	1.21334e-05	0.001855	1	0
NAF1	92345	broad.mit.edu	37	4	164061457	164061457	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:164061457C>T	uc003iqj.2	-	5	990	c.796G>A	c.(796-798)GGT>AGT	p.G266S	NAF1_uc010iqw.1_Missense_Mutation_p.G266S	NM_138386	NP_612395	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 homolog isoform a	266					rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			ovary(2)	2	all_hematologic(180;0.166)	Prostate(90;0.109)				ATTTTAATACCTTTACTCTCA	0.318			NA											7	56					0	0	0.00308	0	0
TLL1	7092	broad.mit.edu	37	4	166964506	166964506	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:166964506G>C	uc003irh.1	+	12	2106	c.1459G>C	c.(1459-1461)GAA>CAA	p.E487Q	TLL1_uc011cjn.1_Missense_Mutation_p.E487Q|TLL1_uc011cjo.1_Missense_Mutation_p.E311Q	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	487	CUB 2.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		CCCGATGAAAGAATGTGTGTG	0.423			NA											17	161					0	0	0.004007	0	0
TLL1	7092	broad.mit.edu	37	4	167020572	167020572	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr4:167020572C>T	uc003irh.1	+	20	3447	c.2800C>T	c.(2800-2802)CAG>TAG	p.Q934*	TLL1_uc011cjn.1_Nonsense_Mutation_p.Q957*|TLL1_uc011cjo.1_Nonsense_Mutation_p.Q758*	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	934	CUB 5.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		ATTATCCTTCCAGACATTTGA	0.468			NA											8	172					0	0	0.004482	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	162943	162943	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:162943C>T	uc003jak.2	+	11	1738	c.1688C>T	c.(1687-1689)GCC>GTC	p.A563V		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	563					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GCTGCAGAGGCCTTCCCCGGG	0.662			NA											3	3					0	0	0.004672	0	0
NSUN2	54888	broad.mit.edu	37	5	6620270	6620271	+	Missense_Mutation	DNP	CC	CC	AA	rs140003855	byFrequency	TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:6620270_6620271CC>AA	uc003jdu.2	-	7	828_829	c.763_764GG>TT	c.(763-765)GGC>TTC	p.G255F	NSUN2_uc003jdt.2_Missense_Mutation_p.G19F|NSUN2_uc011cmk.1_Missense_Mutation_p.G220F|NSUN2_uc003jdv.2_Missense_Mutation_p.G19F	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	NOL1/NOP2/Sun domain family, member 2	255						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1						CTCTTTCCTGCCGTCCACATCT	0.475			NA											10	78					0	0	0.004672	0	0
MARCH11	441061	broad.mit.edu	37	5	16067691	16067691	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:16067691C>G	uc003jfo.2	-	4	1311	c.1098G>C	c.(1096-1098)AGG>AGC	p.R366S	MARCH11_uc010itw.1_Missense_Mutation_p.R122S	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	366						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						CACACTGAAACCTTGGTGAGG	0.502			NA											34	124					0	0	0.003755	0	0
CDH18	1016	broad.mit.edu	37	5	19473707	19473707	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:19473707G>T	uc003jgc.2	-	12	2378	c.2001C>A	c.(1999-2001)GAC>GAA	p.D667E	CDH18_uc003jgd.2_Missense_Mutation_p.D667E|CDH18_uc011cnm.1_3'UTR	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	667	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					AGGCCTCTGTGTCTTCCTCTC	0.522			NA											36	165					4.90274e-10	7.32976e-10	0.00623	1	0
CDH18	1016	broad.mit.edu	37	5	19838999	19838999	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:19838999C>A	uc003jgc.2	-	2	474	c.97G>T	c.(97-99)GTG>TTG	p.V33L	CDH18_uc003jgd.2_Missense_Mutation_p.V33L|CDH18_uc011cnm.1_Missense_Mutation_p.V33L	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	33					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.V33V(1)		ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TTTCTCATCACCTTGATGGAG	0.428			NA											10	67					3.86212e-05	4.77085e-05	0.008291	1	0
CDH9	1007	broad.mit.edu	37	5	26906161	26906161	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:26906161C>T	uc003jgs.1	-	5	887	c.718G>A	c.(718-720)GAC>AAC	p.D240N	CDH9_uc010iug.2_Missense_Mutation_p.D240N	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	240	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						CCACCCATGTCTTTGGCCTGT	0.448	Melanoma(8;187 585 15745 40864 52829)		NA											16	121					0	0	0.003163	0	0
CDH6	1004	broad.mit.edu	37	5	31294201	31294201	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:31294201A>G	uc003jhe.1	+	3	687	c.361A>G	c.(361-363)AAA>GAA	p.K121E	CDH6_uc003jhd.1_Missense_Mutation_p.K121E	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	121	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						CAGGGAAGAAAAACCCGTTTA	0.448			NA											24	106					0	0	0.002299	0	0
GOLPH3	64083	broad.mit.edu	37	5	32126342	32126342	+	Silent	SNP	C	C	G	rs147714399		TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:32126342C>G	uc003jhp.1	-	4	1158	c.873G>C	c.(871-873)GCG>GCC	p.A291A		NM_022130	NP_071413	Q9H4A6	GOLP3_HUMAN	golgi phosphoprotein 3	291					cell proliferation|positive regulation of TOR signaling cascade|regulation of mitochondrion organization	cytosol|endosome|Golgi cisterna membrane|mitochondrial intermembrane space|plasma membrane|trans-Golgi network	protein binding			ovary(1)	1						CCGCCACCACCGCCCACAGAA	0.498			NA											31	130					0	0	0.002445	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33577099	33577099	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:33577099G>T	uc003jia.1	-	19	3195	c.3032C>A	c.(3031-3033)TCC>TAC	p.S1011Y	ADAMTS12_uc010iuq.1_Missense_Mutation_p.S926Y	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1011	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TTTTCCATTGGAAATAGTGCC	0.537			NA								HNSCC(64;0.19)			24	125					3.7963e-18	6.25559e-18	0.00333	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33642030	33642030	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:33642030C>A	uc003jia.1	-	11	1766	c.1603G>T	c.(1603-1605)GGG>TGG	p.G535W	ADAMTS12_uc010iuq.1_Missense_Mutation_p.G535W	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	535	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GGTTTCTTCCCCACTGTGATG	0.597			NA								HNSCC(64;0.19)			3	29					6.4e-05	7.8539e-05	0.004672	1	0
SLC45A2	51151	broad.mit.edu	37	5	33947355	33947355	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:33947355C>A	uc003jid.2	-	6	1373	c.1281G>T	c.(1279-1281)CTG>CTT	p.L427L	SLC45A2_uc003jie.2_Silent_p.L427L	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	427	Helical; Name=10; (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						ACAGGCTGCACAGGACCAGGG	0.498	Ovarian(31;380 859 8490 22203 49048)		NA											26	157					9.57634e-11	1.44848e-10	0.00333	1	0
UGT3A2	167127	broad.mit.edu	37	5	36052050	36052050	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:36052050C>A	uc003jjz.1	-	3	326	c.233G>T	c.(232-234)AGT>ATT	p.S78I	UGT3A2_uc011cos.1_Missense_Mutation_p.S44I|UGT3A2_uc011cot.1_5'UTR	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	78	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGCAAGCCAACTGATAACTTG	0.294			NA											4	50					0.000602214	0.000690978	0.000602	1	0
RICTOR	253260	broad.mit.edu	37	5	39074222	39074222	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:39074222G>C	uc003jlp.2	-	2	112	c.88C>G	c.(88-90)CTG>GTG	p.L30V	RICTOR_uc003jlo.2_Missense_Mutation_p.L30V|RICTOR_uc010ivf.2_Translation_Start_Site|RICTOR_uc003jlq.1_Intron|RICTOR_uc011cpk.1_Missense_Mutation_p.L30V	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	30					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					CCTCGGGTCAGATCCAGCGGG	0.517			NA											9	13					0	0	0.008291	0	0
C9	735	broad.mit.edu	37	5	39315949	39315949	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:39315949G>T	uc003jlv.3	-	6	887	c.798C>A	c.(796-798)GGC>GGA	p.G266G		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	266	MACPF.	Cleavage; by thrombin.			complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			AACTACCCTTGCCATGTAAAG	0.313			NA											18	73					4.75885e-15	7.71497e-15	0.00499	1	0
PTGER4	5734	broad.mit.edu	37	5	40692421	40692421	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:40692421A>G	uc003jlz.2	+	3	2000	c.1408A>G	c.(1408-1410)AGC>GGC	p.S470G		NM_000958	NP_000949	P35408	PE2R4_HUMAN	prostaglandin E receptor 4, subtype EP4	470	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			lung(2)	2						CCCTAAGGGGAGCTCCCTGCA	0.493			NA											8	42					0	0	0.000978	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54640386	54640386	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:54640386C>G	uc003jpy.3	+	9	1209	c.943C>G	c.(943-945)CCA>GCA	p.P315A	SKIV2L2_uc011cqi.1_Missense_Mutation_p.P214A	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	315					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TCGGCCCACTCCATTGCAACA	0.338	Melanoma(2;92 134 23744 29976 33782)		NA											6	37					0	0	0.001984	0	0
IPO11	51194	broad.mit.edu	37	5	61923142	61923142	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:61923142C>T	uc003jtc.2	+	30	3115	c.2925C>T	c.(2923-2925)TTC>TTT	p.F975F	IPO11_uc011cqr.1_Silent_p.F1015F|IPO11_uc010iwr.2_3'UTR|IPO11_uc003jte.2_Silent_p.F94F	NM_016338	NP_057422	Q9UI26	IPO11_HUMAN	Ran binding protein 11 isoform 2	975						cytoplasm|nucleus	protein binding			lung(2)|skin(2)	4		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		TGCAAGGATTCTAAGAGCACA	0.493			NA											4	62					0	0	0.009096	0	0
HTR1A	3350	broad.mit.edu	37	5	63256905	63256905	+	Silent	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:63256905G>C	uc011cqt.1	-	1	642	c.642C>G	c.(640-642)CTC>CTG	p.L214L		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	214	Helical; Name=5; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	TGCGCCCATAGAGAACCAGCA	0.582			NA											17	138					0	0	0.00499	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64748563	64748563	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:64748563C>G	uc003jtp.2	-	5	1628	c.814G>C	c.(814-816)GAA>CAA	p.E272Q	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_5'UTR	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	272	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		ATGTAATGTTCAATGTCTTTG	0.368			NA											5	70					0	0	0.001168	0	0
MAST4	375449	broad.mit.edu	37	5	66055638	66055638	+	Silent	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:66055638G>C	uc003jur.3	+	2	773	c.465G>C	c.(463-465)CTG>CTC	p.L155L	MAST4_uc010iwz.2_Silent_p.L155L	NM_198828	NP_942123	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	155						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AAAGACAGCTGAGTGAGGATG	0.512			NA											6	45					0	0	0.001984	0	0
PDE8B	8622	broad.mit.edu	37	5	76709008	76709008	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:76709008C>T	uc003kfa.2	+	17	1830	c.1785C>T	c.(1783-1785)ACC>ACT	p.T595T	PDE8B_uc003kfb.2_Silent_p.T575T|PDE8B_uc003kfc.2_Silent_p.T540T|PDE8B_uc003kfd.2_Silent_p.T548T|PDE8B_uc003kfe.2_Silent_p.T498T	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	595	Catalytic (By similarity).				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		GTTCTGAAACCACTCTTCGGG	0.498			NA											13	150					0	0	0.001855	0	0
OTP	23440	broad.mit.edu	37	5	76932657	76932657	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:76932657A>G	uc003kfg.2	-	2	584	c.436T>C	c.(436-438)TCC>CCC	p.S146P		NM_032109	NP_115485	Q5XKR4	OTP_HUMAN	orthopedia homeobox	146	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_lung(232;0.00051)|Lung NSC(167;0.000601)|Ovarian(174;0.0105)|Prostate(461;0.214)		OV - Ovarian serous cystadenocarcinoma(54;9.04e-51)|Epithelial(54;1.62e-45)|all cancers(79;4.4e-41)		TGCACTCGGGACTCGGTCAGC	0.612			NA											4	74					0	0	0.009096	0	0
AP3B1	8546	broad.mit.edu	37	5	77409608	77409608	+	Silent	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:77409608T>A	uc003kfj.2	-	19	2342	c.2217A>T	c.(2215-2217)ACA>ACT	p.T739T		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	739	Glu/Ser-rich.				endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		TCCTCTTGGCTGTTCTTTTGT	0.458			NA							Hermansky-Pudlak_syndrome				8	136					0	0	0.008291	0	0
ACOT12	134526	broad.mit.edu	37	5	80631677	80631677	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:80631677C>A	uc003khl.3	-	12	1227	c.1172G>T	c.(1171-1173)TGG>TTG	p.W391L	RNU5E_uc011cto.1_Intron	NM_130767	NP_570123	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	391	START.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(1)|kidney(1)	2		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		CTTTTCAACCCAAACAGATAA	0.353			NA											11	73					0.000978159	0.00111244	0.000978	1	0
MAN2A1	4124	broad.mit.edu	37	5	109155485	109155485	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:109155485A>G	uc003kou.1	+	14	3188	c.2225A>G	c.(2224-2226)GAT>GGT	p.D742G		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	742	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		AAAGTAGAAGATAGCGGAATT	0.328			NA											31	145					0	0	0.008361	0	0
SEMA6A	57556	broad.mit.edu	37	5	115783374	115783374	+	Missense_Mutation	SNP	A	A	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:115783374A>C	uc010jck.2	-	19	2737	c.2028T>G	c.(2026-2028)CAT>CAG	p.H676Q	SEMA6A_uc003krx.3_Missense_Mutation_p.H693Q|SEMA6A_uc011cwe.1_Missense_Mutation_p.H55Q|SEMA6A_uc003krv.3_Missense_Mutation_p.H103Q|SEMA6A_uc003krw.3_Missense_Mutation_p.H153Q|SEMA6A_uc010jcj.2_Missense_Mutation_p.H220Q	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	676	Cytoplasmic (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		CTTTGCGCCGATGATCACAGA	0.622			NA											3	31					0	0	0.004672	0	0
MEGF10	84466	broad.mit.edu	37	5	126791128	126791128	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:126791128T>C	uc003kuh.3	+	25	3423	c.3061T>C	c.(3061-3063)TGC>CGC	p.C1021R	MEGF10_uc003kui.3_Missense_Mutation_p.C1021R	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	1021	Cytoplasmic (Potential).|Necessary for formation of large intracellular vacuoles.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		TTCAAGTAACTGCTCCCTAAG	0.418			NA											34	165					0	0	0.00874	0	0
FBN2	2201	broad.mit.edu	37	5	127595411	127595411	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:127595411G>T	uc003kuu.2	-	65	8914	c.8475C>A	c.(8473-8475)ATC>ATA	p.I2825I		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2825					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGAGGGGCTGGATGGCGGGCC	0.552			NA											21	96					4.54149e-19	7.53853e-19	0.002299	1	0
FBN2	2201	broad.mit.edu	37	5	127648325	127648325	+	Splice_Site	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:127648325C>A	uc003kuu.2	-	37	5318	c.4879_splice	c.e37+1	p.T1627_splice		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor						bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTTGTACTTACTGCTATTGAC	0.502			NA											22	302					9.86323e-18	1.61642e-17	0.003954	1	0
FBN2	2201	broad.mit.edu	37	5	127782300	127782300	+	Splice_Site	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:127782300C>G	uc003kuu.2	-	7	1266	c.827_splice	c.e7-1	p.D276_splice	FBN2_uc003kuv.2_Splice_Site_p.D243_splice|FBN2_uc003kuw.3_Splice_Site_p.D276_splice|FBN2_uc003kux.1_Intron	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor						bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCATCAACATCTGCAAGAAGA	0.363			NA											16	103					0	0	0.001882	0	0
FSTL4	23105	broad.mit.edu	37	5	132569153	132569153	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:132569153G>T	uc003kyn.1	-	8	1189	c.971C>A	c.(970-972)TCC>TAC	p.S324Y		NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	324	Ig-like 1.					extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTCGTGGCCGGAAGCATGGCA	0.542			NA											11	52					7.03913e-09	1.01055e-08	0.001368	1	0
KDM3B	51780	broad.mit.edu	37	5	137727215	137727215	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:137727215G>C	uc003lcy.1	+	8	2094	c.1894G>C	c.(1894-1896)GAG>CAG	p.E632Q	KDM3B_uc010jew.1_Missense_Mutation_p.E288Q|KDM3B_uc011cys.1_Intron	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	632					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						GTCCCGAGAAGAGCCTTCTAA	0.502			NA											17	107					0	0	0.007413	0	0
PAIP2	51247	broad.mit.edu	37	5	138700367	138700367	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:138700367G>T	uc003led.2	+	3	430	c.253G>T	c.(253-255)GAC>TAC	p.D85Y	PAIP2_uc003lee.2_Missense_Mutation_p.D85Y|PAIP2_uc003lef.2_Missense_Mutation_p.D85Y	NM_016480	NP_057564	Q9BPZ3	PAIP2_HUMAN	poly(A) binding protein interacting protein 2	85					negative regulation of translational initiation	cytoplasm	protein binding|translation repressor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			ACAAACTATGGACCAAATCCA	0.378			NA											13	83					0.00136819	0.00153476	0.001368	1	0
PSD2	84249	broad.mit.edu	37	5	139192997	139192997	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:139192997G>T	uc003leu.1	+	3	680	c.475G>T	c.(475-477)GAC>TAC	p.D159Y		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	159					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCAGCCTCGACTCCCTAGA	0.657			NA											10	66					1.08611e-07	1.50885e-07	0.000978	1	0
HARS	3035	broad.mit.edu	37	5	140054305	140054305	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:140054305C>T	uc003lgv.2	-	12	1499	c.1417G>A	c.(1417-1419)GAT>AAT	p.D473N	DND1_uc003lgt.2_5'Flank|HARS_uc003lgu.2_Missense_Mutation_p.D404N|HARS_uc011czm.1_Missense_Mutation_p.D433N|HARS_uc003lgw.2_Missense_Mutation_p.D453N|HARS_uc011czn.1_Missense_Mutation_p.D413N|HARS_uc010jfu.2_Intron|HARS_uc011czo.1_Missense_Mutation_p.D399N|HARS_uc011czp.1_Missense_Mutation_p.D359N	NM_002109	NP_002100	P12081	SYHC_HUMAN	histidyl-tRNA synthetase	473					histidyl-tRNA aminoacylation	cytosol	ATP binding|histidine-tRNA ligase activity			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		L-Histidine(DB00117)	ATGACCCCATCCTTGAGTTCC	0.552			NA											15	101					0	0	0.00245	0	0
PCDHA1	56147	broad.mit.edu	37	5	140166214	140166214	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:140166214G>A	uc003lhb.2	+	1	339	c.339G>A	c.(337-339)CCG>CCA	p.P113P	PCDHA1_uc003lha.2_Silent_p.P113P|PCDHA1_uc003lgz.2_Silent_p.P113P	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	113	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGACAGGCCGCTGCAGGTTT	0.498			NA											10	73					0	0	0.006214	0	0
PCDHA4	56144	broad.mit.edu	37	5	140187260	140187260	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:140187260G>T	uc003lhi.2	+	1	589	c.488G>T	c.(487-489)GGG>GTG	p.G163V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.G163V|PCDHA4_uc011daa.1_Missense_Mutation_p.G163V	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	163	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGATATCGGGGAGAACGCC	0.522			NA											15	59					7.93312e-07	1.0676e-06	0.00245	1	0
PCDHA6	56142	broad.mit.edu	37	5	140207688	140207688	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:140207688C>A	uc003lho.2	+	1	39	c.12C>A	c.(10-12)ACC>ACA	p.T4T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Silent_p.T4T|PCDHA6_uc011dab.1_Silent_p.T4T	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	4					homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTGTTTACCCCGGAGGATA	0.473			NA											26	144					1.75199e-13	2.78529e-13	0.007291	1	0
PCDHA6	56142	broad.mit.edu	37	5	140209902	140209902	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:140209902C>A	uc003lho.2	+	1	2253	c.2226C>A	c.(2224-2226)TCC>TCA	p.S742S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Silent_p.S742S	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	742	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTGTGCTCCAGCGCAGTGG	0.692			NA											12	43					2.80697e-09	4.09483e-09	0.000978	1	0
PCDHA9	9752	broad.mit.edu	37	5	140229524	140229524	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:140229524G>C	uc003lhu.2	+	1	2168	c.1444G>C	c.(1444-1446)GCT>CCT	p.A482P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.A482P	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	482	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCGCGGGACGCTGACGCGCA	0.662	Melanoma(55;1800 1972 14909)		NA											15	70					0	0	0.00245	0	0
PCDHB1	29930	broad.mit.edu	37	5	140433275	140433275	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:140433275G>A	uc003lik.1	+	1	2297	c.2220G>A	c.(2218-2220)CTG>CTA	p.L740L		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	740	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTAACAACCTGGTACAAGGAC	0.373			NA											12	72					0	0	0.00245	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503371	140503371	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:140503371G>T	uc003lip.1	+	1	1791	c.1791G>T	c.(1789-1791)CAG>CAT	p.Q597H		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	597	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTCGGGCCAGAACGCCTGGC	0.716			NA											13	52					2.61681e-11	3.97809e-11	0.00245	1	0
PCDHB11	56125	broad.mit.edu	37	5	140580428	140580429	+	Missense_Mutation	DNP	CC	CC	GA			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:140580428_140580429CC>GA	uc003liy.2	+	1	1081_1082	c.1081_1082CC>GA	c.(1081-1083)CCA>GAA	p.P361E	PCDHB11_uc011daj.1_5'UTR	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	361	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAAAATACGCCAGAGACCGTG	0.401			NA											19	127					0	0	0.004672	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720491	140720491	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:140720491G>T	uc003ljk.1	+	1	2138	c.1953G>T	c.(1951-1953)CAG>CAT	p.Q651H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.Q651H	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	651	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCACGGCCAGCCCCCTCTCT	0.711			NA											8	67					7.48243e-07	1.00996e-06	0.006214	1	0
PCDHGA6	56109	broad.mit.edu	37	5	140754602	140754602	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:140754602G>T	uc003ljy.1	+	1	952	c.952G>T	c.(952-954)GGT>TGT	p.G318C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.G318C	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	318	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTATGAGCTGGGTGTTGAAGC	0.398			NA											37	157					7.04047e-22	1.1839e-21	0.005524	1	0
PCDHGA6	56109	broad.mit.edu	37	5	140755009	140755009	+	Silent	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:140755009C>G	uc003ljy.1	+	1	1359	c.1359C>G	c.(1357-1359)CCC>CCG	p.P453P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.P453P	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	453	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACCTTCCCCCATTCATCCT	0.527			NA											23	135					0	0	0.00333	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140764324	140764324	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:140764324G>T	uc003lka.1	+	1	1858	c.1858G>T	c.(1858-1860)GGG>TGG	p.G620W	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.G620W	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	620	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTTGCGGTTGGGCTGTACAC	0.647			NA											5	42					0.00116845	0.00131559	0.001168	1	0
SH3TC2	79628	broad.mit.edu	37	5	148406269	148406269	+	Silent	SNP	C	C	T	rs145528276	byFrequency	TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:148406269C>T	uc003lpu.2	-	12	3071	c.2919G>A	c.(2917-2919)GTG>GTA	p.V973V	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Silent_p.V617V|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_Silent_p.V520V|SH3TC2_uc010jgx.2_Silent_p.V966V|SH3TC2_uc003lpv.1_Missense_Mutation_p.C556Y|SH3TC2_uc011dbz.1_Missense_Mutation_p.C894Y	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	973							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTTTGGGGACACAGAGCTGT	0.542			NA											10	191					0	0	0.008291	0	0
ARSI	340075	broad.mit.edu	37	5	149678006	149678006	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:149678006G>A	uc003lrv.2	-	2	1070	c.481C>T	c.(481-483)CGT>TGT	p.R161C		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	161						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGCCCCGACGGGTGGGCAGA	0.602			NA											8	45					0	0	0.004482	0	0
RPS14	6208	broad.mit.edu	37	5	149826406	149826406	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:149826406G>A	uc003lsh.2	-	3	543	c.270C>T	c.(268-270)ATC>ATT	p.I90I	uc003lsg.2_5'Flank|RPS14_uc003lsi.2_Silent_p.I90I|RPS14_uc003lsj.2_Silent_p.I90I	NM_001025071	NP_001020242	P62263	RS14_HUMAN	ribosomal protein S14	90					endocrine pancreas development|erythrocyte differentiation|maturation of SSU-rRNA|negative regulation of transcription from RNA polymerase II promoter|ribosomal small subunit assembly|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	mRNA 5'-UTR binding|protein binding|structural constituent of ribosome|translation regulator activity			central_nervous_system(1)	1		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTAGGGCGGTGATACCCAGCT	0.572			NA											9	78					0	0	0.006214	0	0
G3BP1	10146	broad.mit.edu	37	5	151173720	151173720	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:151173720G>T	uc003lun.2	+	5	523	c.352G>T	c.(352-354)GGG>TGG	p.G118W	G3BP1_uc003lum.2_Missense_Mutation_p.G118W|G3BP1_uc011dcu.1_Intron|G3BP1_uc010jhz.2_Intron|G3BP1_uc003luq.2_5'Flank	NM_005754	NP_005745	Q13283	G3BP1_HUMAN	Ras-GTPase-activating protein SH3-domain-binding	118	NTF2.				Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			skin(3)|ovary(1)	4		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)			GGCATTGCAGGGGTCTGTTGC	0.343			NA											8	69					0.000274275	0.000318342	0.004482	1	0
ITK	3702	broad.mit.edu	37	5	156608074	156608074	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:156608074G>T	uc003lwo.1	+	1	168	c.86G>T	c.(85-87)CGC>CTC	p.R29L		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	29	PH.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTTAAAGTCCGCTTCTTTGTG	0.398	Esophageal Squamous(70;1378 1469 8785 19883)		NA	T	SYK	peripheral T-cell lymphoma								12	148					1.5842e-08	2.24927e-08	0.001855	1	0
HMMR	3161	broad.mit.edu	37	5	162900478	162900478	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:162900478G>A	uc003lzf.2	+	9	998	c.816G>A	c.(814-816)AAG>AAA	p.K272K	HMMR_uc003lzh.2_Silent_p.K273K|HMMR_uc003lzg.2_Silent_p.K257K|HMMR_uc011dem.1_Silent_p.K186K	NM_012484	NP_036616	O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor isoform b	272						cell surface|cytoplasm	hyaluronic acid binding				0	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		TAAGCCTTAAGCAGTCTCTTG	0.313			NA											3	41					0	0	0.004672	0	0
ODZ2	57451	broad.mit.edu	37	5	167626894	167626894	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:167626894C>A	uc010jjd.2	+	17	3161	c.3161C>A	c.(3160-3162)CCT>CAT	p.P1054H	ODZ2_uc003lzr.3_Missense_Mutation_p.P831H|ODZ2_uc003lzt.3_Missense_Mutation_p.P427H|ODZ2_uc010jje.2_Missense_Mutation_p.P325H	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		ATCGAGCTCCCTGGTTCCAAT	0.498			NA											27	171					1.7881e-09	2.62546e-09	0.008361	1	0
NPM1	4869	broad.mit.edu	37	5	170819787	170819787	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:170819787G>T	uc011dex.1	+	6	561	c.426G>T	c.(424-426)CGG>CGT	p.R142R	NPM1_uc003mbh.2_Silent_p.R142R|NPM1_uc003mbi.2_Silent_p.R142R|NPM1_uc003mbj.2_Silent_p.R142R	NM_002520	NP_002511	P06748	NPM_HUMAN	nucleophosmin 1 isoform 1	142	Required for interaction with SENP3.				anti-apoptosis|cell aging|CenH3-containing nucleosome assembly at centromere|centrosome cycle|DNA repair|interspecies interaction between organisms|intracellular protein transport|negative regulation of cell proliferation|negative regulation of centrosome duplication|nucleocytoplasmic transport|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|regulation of endodeoxyribonuclease activity|regulation of endoribonuclease activity|ribosome assembly|signal transduction	nucleolus|nucleoplasm|ribonucleoprotein complex|spindle pole centrosome	histone binding|NF-kappaB binding|protein binding|protein heterodimerization activity|protein homodimerization activity|ribosomal large subunit binding|ribosomal small subunit binding|RNA binding|Tat protein binding|transcription coactivator activity|unfolded protein binding		NPM1/ALK(632)	haematopoietic_and_lymphoid_tissue(3109)|skin(1)	3110	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CTGGAAAGCGGTCTGCCCCTG	0.393			NA	T|F 	ALK|RARA|MLF1	NHL|APL|AML								16	107					1.45105e-14	2.32735e-14	0.006122	1	0
ZNF454	285676	broad.mit.edu	37	5	178392158	178392158	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:178392158G>T	uc003mjo.1	+	5	1024	c.753G>T	c.(751-753)AAG>AAT	p.K251N	ZNF454_uc010jkz.1_Missense_Mutation_p.K251N	NM_182594	NP_872400	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	251	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		AATGTGGCAAGGCCTTCTCAG	0.428			NA											13	91					0.000151284	0.000180462	0.001855	1	0
HIST1H1T	3010	broad.mit.edu	37	6	26108121	26108121	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:26108121C>G	uc003ngj.2	-	1	244	c.201G>C	c.(199-201)AAG>AAC	p.K67N		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	67	H15.				cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						CCAATGCCTTCTTGAGCGCAA	0.517			NA											27	66					0	0	0.007291	0	0
HIST1H2AC	8334	broad.mit.edu	37	6	26124671	26124671	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:26124671G>A	uc003ngm.2	+	1	299	c.211G>A	c.(211-213)GCT>ACT	p.A71T	HIST1H2BC_uc003ngk.3_5'Flank|HIST1H2BC_uc003ngl.2_5'Flank|HIST1H2AC_uc003ngn.2_RNA|HIST1H2AC_uc003ngo.2_RNA|HIST1H2AC_uc003ngp.2_Missense_Mutation_p.A71T	NM_003512	NP_003503	Q93077	H2A1C_HUMAN	histone cluster 1, H2ac	71					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CGGCAACGCGGCTCGCGACAA	0.647			NA											11	34					0	0	0.001368	0	0
OR2B2	81697	broad.mit.edu	37	6	27879654	27879654	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:27879654G>T	uc011dkw.1	-	1	444	c.444C>A	c.(442-444)TCC>TCA	p.S148S		NM_033057	NP_149046	Q9GZK3	OR2B2_HUMAN	olfactory receptor, family 2, subfamily B,	148	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CACTAATCCAGGATGCAGCTG	0.468			NA											11	59					0.00829132	0.00897729	0.008291	1	0
GPX5	2880	broad.mit.edu	37	6	28499572	28499572	+	Missense_Mutation	SNP	G	G	C	rs149572375		TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:28499572G>C	uc003nll.2	+	3	261	c.259G>C	c.(259-261)GAG>CAG	p.E87Q	GPX5_uc003nlm.2_Intron|GPX5_uc003nln.2_Intron	NM_001509	NP_001500	O75715	GPX5_HUMAN	glutathione peroxidase 5 isoform 1 precursor	87					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity	p.E87K(1)		skin(1)	1					Glutathione(DB00143)	TGCACTCCAGGAGGAGCTGAA	0.448			NA											77	235					0	0	0.00361	0	0
UBD	10537	broad.mit.edu	37	6	29523866	29523866	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:29523866C>G	uc003nmo.2	-	2	513	c.289G>C	c.(289-291)GAT>CAT	p.D97H	GABBR1_uc003nmp.3_3'UTR	NM_006398	NP_006389	O15205	UBD_HUMAN	ubiquitin D	97	Ubiquitin 2.				aggresome assembly|myeloid dendritic cell differentiation|negative regulation of mitotic prometaphase|positive regulation of apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	aggresome|cytoplasm|nucleus	proteasome binding				0						TTTGCCTCATCACCTGACTCC	0.512			NA											9	32					0	0	0.006214	0	0
PRRT1	80863	broad.mit.edu	37	6	32117104	32117104	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:32117104G>T	uc003nzt.2	-	4	932	c.816C>A	c.(814-816)TCC>TCA	p.S272S	PRRT1_uc003nzs.2_Silent_p.S313S|PRRT1_uc003nzu.2_Missense_Mutation_p.L165I	NM_030651	NP_085154	Q99946	PRRT1_HUMAN	NG5 protein	272					response to biotic stimulus	integral to membrane				breast(1)	1						GGGAGATGAAGGAGAAGTTCC	0.647			NA											8	13					2.17888e-05	2.74029e-05	0.006214	1	0
DNAH8	1769	broad.mit.edu	37	6	38854628	38854628	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:38854628C>A	uc003ooe.1	+	55	8270	c.7670C>A	c.(7669-7671)CCT>CAT	p.P2557H		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TTGGACAAGCCTGGAGACTTC	0.388			NA											10	71					3.86212e-05	4.77085e-05	0.008291	1	0
RPL7L1	285855	broad.mit.edu	37	6	42851245	42851245	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:42851245C>T	uc003osq.1	+	3	182	c.177C>T	c.(175-177)TCC>TCT	p.S59S	RPL7L1_uc011dux.1_Silent_p.S59S|RPL7L1_uc010jxw.1_5'UTR|RPL7L1_uc003osr.1_5'UTR|RPL7L1_uc011duy.1_Silent_p.S59S|RPL7L1_uc003oss.1_5'UTR|RPL7L1_uc003ost.2_Silent_p.S59S|RPL7L1_uc003osu.2_RNA	NM_198486	NP_940888	Q6DKI1	RL7L_HUMAN	ribosomal protein L7-like 1	59					translation	large ribosomal subunit	protein binding|structural constituent of ribosome				0	Colorectal(47;0.196)		Colorectal(64;0.00237)|all cancers(41;0.00288)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.088)			TACATGATTCCTGGCGGCAGA	0.468			NA											5	72					0	0	0.000602	0	0
CUL9	23113	broad.mit.edu	37	6	43182863	43182863	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:43182863G>T	uc003ouk.2	+	30	5810	c.5735G>T	c.(5734-5736)GGC>GTC	p.G1912V	CUL9_uc003oul.2_Missense_Mutation_p.G1884V|CUL9_uc010jyk.2_Missense_Mutation_p.G1064V|CUL9_uc003oun.2_5'UTR	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	1912					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						GGAACCCTGGGCCACACTGTT	0.567			NA											15	113					0.000422831	0.000489509	0.004007	1	0
TMEM63B	55362	broad.mit.edu	37	6	44107259	44107259	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:44107259C>T	uc003owr.2	+	7	527	c.463C>T	c.(463-465)CAG>TAG	p.Q155*	TMEM63B_uc003owq.1_Nonsense_Mutation_p.Q155*|TMEM63B_uc010jyy.1_Nonsense_Mutation_p.Q58*|TMEM63B_uc003ows.2_Nonsense_Mutation_p.Q58*|TMEM63B_uc010jyz.2_5'Flank	NM_018426	NP_060896	Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	155						integral to membrane	nucleotide binding|protein binding			pancreas(2)|central_nervous_system(1)	3	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			CCTGTCCTTTCAGCGGCACAT	0.597			NA											8	42					0	0	0.004482	0	0
PGK2	5232	broad.mit.edu	37	6	49753978	49753978	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:49753978G>A	uc003ozu.2	-	1	1030	c.923C>T	c.(922-924)TCT>TTT	p.S308F		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	308					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					CCAGCCAGGAGATATGCCAGA	0.463			NA											12	190					0	0	0.001855	0	0
PKHD1	5314	broad.mit.edu	37	6	51612989	51612989	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:51612989G>T	uc003pah.1	-	58	9701	c.9425C>A	c.(9424-9426)ACC>AAC	p.T3142N	PKHD1_uc010jzn.1_Missense_Mutation_p.T1125N|PKHD1_uc003pai.2_Missense_Mutation_p.T3142N	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3142	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					AGAGATTCTGGTACAGTTGTC	0.438			NA											48	282					6.08268e-21	1.01905e-20	0.00361	1	0
GCLC	2729	broad.mit.edu	37	6	53363677	53363677	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:53363677C>T	uc003pbw.1	-	16	2179	c.1791G>A	c.(1789-1791)ATG>ATA	p.M597I	GCLC_uc003pbv.1_Missense_Mutation_p.M321I	NM_001498	NP_001489	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	597					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			ovary(1)|central_nervous_system(1)	2	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	GGCTATAATTCATTTCATCAG	0.388			NA											12	143					0	0	0.001855	0	0
HCRTR2	3062	broad.mit.edu	37	6	55120106	55120106	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:55120106A>G	uc003pcl.2	+	3	890	c.575A>G	c.(574-576)GAG>GGG	p.E192G	HCRTR2_uc010jzv.2_RNA|HCRTR2_uc010jzw.1_Missense_Mutation_p.E127G	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	192	Helical; Name=4; (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			ATCGTCATGGAGTGCAGCACC	0.498			NA											6	56					0	0	0.001168	0	0
GFRAL	389400	broad.mit.edu	37	6	55198740	55198740	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:55198740C>T	uc003pcm.1	+	3	400	c.314C>T	c.(313-315)TCA>TTA	p.S105L		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	105	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			ATCAATAAATCAGGTAATATT	0.269			NA											9	63					0	0	0.001368	0	0
DST	667	broad.mit.edu	37	6	56492813	56492813	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:56492813T>A	uc003pdf.2	-	32	4551	c.4523A>T	c.(4522-4524)CAG>CTG	p.Q1508L	DST_uc003pcz.3_Missense_Mutation_p.Q1330L|DST_uc011dxj.1_Missense_Mutation_p.Q1359L|DST_uc011dxk.1_Missense_Mutation_p.Q1370L|DST_uc003pcy.3_Missense_Mutation_p.Q1004L|DST_uc003pdb.2_Missense_Mutation_p.Q1004L|DST_uc003pdc.3_Missense_Mutation_p.Q1004L|DST_uc003pdd.3_Missense_Mutation_p.Q1004L	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	1330					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTGATTCAACTGTGTGGCTAG	0.388			NA											16	81					0	0	0.006122	0	0
ZNF451	26036	broad.mit.edu	37	6	57012630	57012630	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:57012630G>T	uc003pdm.1	+	10	1971	c.1747G>T	c.(1747-1749)GCT>TCT	p.A583S	ZNF451_uc003pdl.2_Missense_Mutation_p.A583S|ZNF451_uc003pdn.1_Missense_Mutation_p.A583S|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.A583S	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	583					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TAATTTGACTGCTAACAAGCC	0.388			NA											8	104					0.00307968	0.00339969	0.00308	1	0
LGSN	51557	broad.mit.edu	37	6	63990290	63990290	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:63990290T>C	uc003peh.2	-	4	1200	c.1166A>G	c.(1165-1167)AAC>AGC	p.N389S	LGSN_uc003pei.2_3'UTR	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	389					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	TATACAGCTGTTGTCATTGTA	0.463			NA											33	181					0	0	0.004878	0	0
RIMS1	22999	broad.mit.edu	37	6	72947557	72947557	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:72947557G>T	uc003pga.2	+	9	1966	c.1889G>T	c.(1888-1890)CGA>CTA	p.R630L	RIMS1_uc011dyb.1_Missense_Mutation_p.R256L|RIMS1_uc003pgc.2_Missense_Mutation_p.R256L|RIMS1_uc010kaq.2_Missense_Mutation_p.R104L|RIMS1_uc011dyc.1_Missense_Mutation_p.R104L|RIMS1_uc010kar.2_Missense_Mutation_p.R23L|RIMS1_uc011dyd.1_Missense_Mutation_p.R89L|RIMS1_uc003pgb.3_Missense_Mutation_p.R256L|RIMS1_uc010kas.1_Missense_Mutation_p.R89L	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	630	PDZ.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GACTTAGGACGACTTGGTGCT	0.343			NA											6	45					8.12818e-05	9.7994e-05	0.001984	1	0
OOEP	441161	broad.mit.edu	37	6	74079496	74079496	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:74079496G>C	uc003pgu.3	-	1	20	c.20C>G	c.(19-21)GCC>GGC	p.A7G	OOEP_uc003pgv.3_Intron	NM_001080507	NP_001073976	A6NGQ2	OOEP_HUMAN	oocyte expressed protein homolog	7						cytoplasm					0						GGACTCAGCGGCACCAGCATC	0.667			NA											8	82					0	0	0.004482	0	0
IBTK	25998	broad.mit.edu	37	6	82924239	82924239	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:82924239T>C	uc003pjl.1	-	12	2436	c.1909A>G	c.(1909-1911)ACA>GCA	p.T637A	IBTK_uc011dyv.1_Missense_Mutation_p.T637A|IBTK_uc011dyw.1_Intron|IBTK_uc010kbi.1_Missense_Mutation_p.T331A|IBTK_uc003pjm.2_Missense_Mutation_p.T637A	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	637	BTB 1.				negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		CAAGTATCTGTGTATATAAAT	0.343			NA											4	63					0	0	0.009096	0	0
TPBG	7162	broad.mit.edu	37	6	83075585	83075585	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:83075585G>A	uc003pjn.3	+	3	1843	c.907G>A	c.(907-909)GCA>ACA	p.A303T	TPBG_uc010kbj.2_Missense_Mutation_p.A303T|TPBG_uc003pjo.2_Missense_Mutation_p.A303T	NM_006670	NP_006661	Q13641	TPBG_HUMAN	trophoblast glycoprotein precursor	303	Extracellular (Potential).|LRRCT.				cell adhesion	integral to plasma membrane				central_nervous_system(1)	1		all_cancers(76;0.000805)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0897)		BRCA - Breast invasive adenocarcinoma(397;0.107)		CTGCCACATGGCAGACATGGT	0.542			NA											12	53					0	0	0.000978	0	0
GPR63	81491	broad.mit.edu	37	6	97246829	97246829	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:97246829T>A	uc010kcl.2	-	3	1257	c.779A>T	c.(778-780)TAC>TTC	p.Y260F	GPR63_uc003pou.2_Missense_Mutation_p.Y260F	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	260	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		CATAAATGAGTACAGTATTAC	0.473			NA											14	85					0	0	0.00499	0	0
C6orf167	253714	broad.mit.edu	37	6	97597850	97597850	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:97597850T>C	uc003ppb.2	-	24	3795	c.3529A>G	c.(3529-3531)AGC>GGC	p.S1177G	C6orf167_uc011eaf.1_Missense_Mutation_p.S1137G	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	1177					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		TCTAAAATGCTGTAAACCTGG	0.418			NA											3	40					0	0	0.009096	0	0
BEND3	57673	broad.mit.edu	37	6	107391909	107391909	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:107391909G>A	uc003prs.2	-	5	1136	c.486C>T	c.(484-486)AGC>AGT	p.S162S		NM_001080450	NP_001073919	Q5T5X7	BEND3_HUMAN	BEN domain containing 3	162										ovary(3)	3						AGGGGCTGTTGCTGGCGTTTG	0.572			NA											12	76					0	0	0.001855	0	0
SCML4	256380	broad.mit.edu	37	6	108067985	108067985	+	Missense_Mutation	SNP	T	T	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:108067985T>G	uc010kdf.2	-	4	646	c.395A>C	c.(394-396)CAG>CCG	p.Q132P	SCML4_uc003prz.3_Missense_Mutation_p.Q74P|SCML4_uc011eam.1_Missense_Mutation_p.Q132P|SCML4_uc003psa.3_Missense_Mutation_p.Q103P	NM_198081	NP_932347	Q8N228	SCML4_HUMAN	sex comb on midleg-like 4	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		all_cancers(87;3.26e-06)|Acute lymphoblastic leukemia(125;3.08e-08)|all_hematologic(75;1.15e-06)|all_epithelial(87;0.00142)|Colorectal(196;0.0316)		BRCA - Breast invasive adenocarcinoma(108;0.01)|Epithelial(106;0.0509)|all cancers(137;0.0586)|OV - Ovarian serous cystadenocarcinoma(136;0.0758)		GACGGCCTGCTGCAGCACCGC	0.622			NA											10	57					0	0	0.006214	0	0
SEC63	11231	broad.mit.edu	37	6	108224056	108224056	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:108224056G>A	uc003psc.3	-	12	1470	c.1201C>T	c.(1201-1203)CAT>TAT	p.H401Y	SEC63_uc003psb.3_Missense_Mutation_p.H261Y	NM_007214	NP_009145	Q9UGP8	SEC63_HUMAN	SEC63-like protein	401	SEC63 1.|Cytoplasmic (Potential).				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			ovary(1)|skin(1)	2		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		ACCTTCTTATGATTAGAAACC	0.388			NA											12	158					0	0	0.001368	0	0
WASF1	8936	broad.mit.edu	37	6	110424732	110424732	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:110424732C>G	uc003ptv.1	-	9	1579	c.742G>C	c.(742-744)GGA>CGA	p.G248R	WASF1_uc003ptw.1_Missense_Mutation_p.G248R|WASF1_uc003ptx.1_Missense_Mutation_p.G248R|WASF1_uc003pty.1_Missense_Mutation_p.G248R	NM_003931	NP_003922	Q92558	WASF1_HUMAN	Wiskott-Aldrich syndrome protein family member	248					actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		GAGTAAGATCCATCCATATGA	0.338			NA											6	55					0	0	0.001984	0	0
DDO	8528	broad.mit.edu	37	6	110714395	110714395	+	Silent	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:110714395G>C	uc003puc.2	-	5	697	c.693C>G	c.(691-693)GTC>GTG	p.V231V	C6orf186_uc003pub.2_Intron|DDO_uc003pud.2_Silent_p.V172V	NM_003649	NP_003640	Q99489	OXDD_HUMAN	D-aspartate oxidase isoform a	203					aspartate catabolic process	peroxisome	binding|D-amino-acid oxidase activity|D-aspartate oxidase activity			ovary(2)|breast(1)	3		all_cancers(87;3.47e-21)|all_epithelial(87;9.03e-20)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_lung(197;2.98e-05)|Lung NSC(302;3.25e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.00327)		all cancers(137;2.54e-48)|Epithelial(106;3.11e-44)|OV - Ovarian serous cystadenocarcinoma(136;2.08e-24)|BRCA - Breast invasive adenocarcinoma(108;0.000141)|GBM - Glioblastoma multiforme(226;0.00046)		GAACTTGGAGGACTTGGCCCC	0.502			NA											16	145					0	0	0.00499	0	0
HDAC2	3066	broad.mit.edu	37	6	114279889	114279889	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:114279889G>A	uc003pwd.1	-	3	489	c.489C>T	c.(487-489)CAC>CAT	p.H163H	HDAC2_uc003pwc.1_Silent_p.H39H|HDAC2_uc003pwe.1_Silent_p.H39H	NM_001527	NP_001518	Q92769	HDAC2_HUMAN	histone deacetylase 2	69	Histone deacetylase.				blood coagulation|dendrite development|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|maintenance of chromatin silencing|negative regulation of apoptosis|negative regulation of cell cycle|negative regulation of neuron projection development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of proteolysis|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|ESC/E(Z) complex|NuRD complex|Sin3 complex	chromatin binding|enzyme binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|sequence-specific DNA binding|transcription factor binding			skin(2)|ovary(1)|central_nervous_system(1)	4		all_cancers(87;0.000629)|all_epithelial(87;0.00274)|Colorectal(196;0.0317)|all_lung(197;0.24)		all cancers(137;0.00318)|OV - Ovarian serous cystadenocarcinoma(136;0.00569)|Epithelial(106;0.0112)|GBM - Glioblastoma multiforme(226;0.0832)	Vorinostat(DB02546)	ACTCATCACTGTGATATTTTG	0.363			NA											13	84					0	0	0.001368	0	0
VNN2	8875	broad.mit.edu	37	6	133072641	133072641	+	Silent	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:133072641T>A	uc003qdt.2	-	5	854	c.843A>T	c.(841-843)GCA>GCT	p.A281A	VNN2_uc003qds.2_5'UTR|VNN2_uc010kgb.2_Intron|VNN2_uc003qdv.2_Silent_p.A228A	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	281	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		GACCATTTGGTGCATAAATAC	0.418			NA											8	65					0	0	0.004482	0	0
TCF21	6943	broad.mit.edu	37	6	134210674	134210674	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:134210674G>A	uc003qei.3	+	1	415	c.139G>A	c.(139-141)GGG>AGG	p.G47R	uc003qeg.1_5'Flank|TCF21_uc003qej.2_Missense_Mutation_p.G47R	NM_003206	NP_003197	O43680	TCF21_HUMAN	transcription factor 21	47					branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity				0	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)		CTGCGAGAATGGGTCTCCCCA	0.597			NA											6	37					0	0	0.001168	0	0
OLIG3	167826	broad.mit.edu	37	6	137815202	137815202	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:137815202G>T	uc003qhp.1	-	1	330	c.106C>A	c.(106-108)CGT>AGT	p.R36S		NM_175747	NP_786923	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	36					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		GAGTTGAGACGGCTCTCCtgg	0.522			NA											11	66					3.07112e-06	4.06035e-06	0.000978	1	0
SYNE1	23345	broad.mit.edu	37	6	152746527	152746527	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:152746527G>C	uc010kiw.2	-	39	5858	c.5256C>G	c.(5254-5256)ATC>ATG	p.I1752M	SYNE1_uc003qot.3_Missense_Mutation_p.I1759M|SYNE1_uc003qou.3_Missense_Mutation_p.I1752M|SYNE1_uc010kjb.1_Missense_Mutation_p.I1735M	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1752	Spectrin 2.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTTTGTTAATGATCTGTGGTA	0.308			NA								HNSCC(10;0.0054)			15	105					0	0	0.008871	0	0
RBM16	22828	broad.mit.edu	37	6	155153150	155153150	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:155153150C>G	uc003qqa.2	+	21	2669	c.2437C>G	c.(2437-2439)CTG>GTG	p.L813V	TIAM2_uc003qqb.2_5'Flank|RBM16_uc011efj.1_Missense_Mutation_p.L879V|RBM16_uc011efk.1_Missense_Mutation_p.L858V|RBM16_uc003qpz.2_Missense_Mutation_p.L813V|RBM16_uc010kji.2_Missense_Mutation_p.L834V	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	813	Pro-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		TTCTGGAATTCTGGGAGTCCA	0.403			NA											17	93					0	0	0.008871	0	0
IGF2R	3482	broad.mit.edu	37	6	160505029	160505029	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:160505029G>A	uc003qta.2	+	40	6029	c.5881G>A	c.(5881-5883)GAG>AAG	p.E1961K		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	1961	13.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		TGATGAAGATGAGGACATTGG	0.368			NA											8	80					0	0	0.006214	0	0
DGKB	1607	broad.mit.edu	37	7	14775748	14775748	+	Silent	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:14775748A>T	uc003ssz.2	-	4	427	c.240T>A	c.(238-240)ACT>ACA	p.T80T	DGKB_uc011jxt.1_Silent_p.T73T|DGKB_uc003sta.2_Silent_p.T80T|DGKB_uc011jxu.1_Silent_p.T80T|DGKB_uc011jxv.1_Silent_p.T80T	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	80					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	AAAGGTGTGCAGTGAAATCAT	0.358			NA											4	20					0	0	0.009096	0	0
ANKMY2	57037	broad.mit.edu	37	7	16649287	16649287	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:16649287G>C	uc003sti.2	-	7	1050	c.850C>G	c.(850-852)CAG>GAG	p.Q284E	ANKMY2_uc010ktz.2_RNA	NM_020319	NP_064715	Q8IV38	ANKY2_HUMAN	ankyrin repeat and MYND domain containing 2	284						cilium	zinc ion binding			central_nervous_system(1)	1	Lung NSC(10;0.103)|all_lung(11;0.204)			UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		CGAACCAGCTGCTGGAGGAGT	0.398			NA											5	48					0	0	0.001168	0	0
SP4	6671	broad.mit.edu	37	7	21516717	21516717	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:21516717G>C	uc003sva.2	+	4	1880	c.1699G>C	c.(1699-1701)GGA>CGA	p.G567R	SP4_uc003svb.2_Missense_Mutation_p.G254R	NM_003112	NP_003103	Q02446	SP4_HUMAN	Sp4 transcription factor	567					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(3)|skin(2)	5						AGGACAAGATGGAGTAAAAGT	0.378			NA											8	41					0	0	0.00308	0	0
NOD1	10392	broad.mit.edu	37	7	30475652	30475652	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:30475652C>T	uc003tav.2	-	11	3106	c.2583G>A	c.(2581-2583)GCG>GCA	p.A861A		NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	861	LRR 6.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						GCAGGGCCCTCGCAAGGCTCT	0.368			NA											11	35					0	0	0.003163	0	0
FKBP9	11328	broad.mit.edu	37	7	33020067	33020067	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:33020067G>T	uc003tdh.2	+	5	976	c.795G>T	c.(793-795)AAG>AAT	p.K265N	AVL9_uc011kai.1_Intron|FKBP9_uc011kak.1_RNA|FKBP9_uc011kal.1_Missense_Mutation_p.K318N|FKBP9_uc011kam.1_Missense_Mutation_p.K33N|FKBP9_uc003tdg.2_Missense_Mutation_p.K265N	NM_007270	NP_009201	O95302	FKBP9_HUMAN	FK506 binding protein 9 precursor	265					protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|ovary(1)	14			GBM - Glioblastoma multiforme(11;0.0156)			TTGAGAACAAGGTAGTACCTG	0.468			NA											22	211					2.32416e-17	3.80202e-17	0.002299	1	0
AOAH	313	broad.mit.edu	37	7	36763639	36763639	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:36763639G>T	uc003tfh.3	-	1	516	c.115C>A	c.(115-117)CAC>AAC	p.H39N	AOAH_uc010kxf.2_Missense_Mutation_p.H39N|AOAH_uc011kba.1_Missense_Mutation_p.H39N	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	39	Saposin B-type.				inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						ACACAGGTGTGCCCATTCGAG	0.438			NA											5	32					1.23904e-05	1.57585e-05	0.000602	1	0
GLI3	2737	broad.mit.edu	37	7	42085017	42085017	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:42085017C>A	uc011kbh.1	-	6	883	c.792G>T	c.(790-792)GGG>GGT	p.G264G	GLI3_uc011kbg.1_Silent_p.G205G	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	264					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						TGTGGATGGCCCCCGTGCCGG	0.522			NA							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				18	163					1.01871e-10	1.53572e-10	0.008871	1	0
NUDCD3	23386	broad.mit.edu	37	7	44524670	44524670	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:44524670G>C	uc003tkz.2	-	2	592	c.406C>G	c.(406-408)CCA>GCA	p.P136A		NM_015332	NP_056147	Q8IVD9	NUDC3_HUMAN	NudC domain containing 3	136											0						ACAGGGCCTGGAGGCTGCACT	0.542			NA											8	46					0	0	0.00308	0	0
PCLO	27445	broad.mit.edu	37	7	82544191	82544191	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:82544191T>A	uc003uhx.2	-	7	13400	c.13111A>T	c.(13111-13113)ATG>TTG	p.M4371L	PCLO_uc003uhv.2_Missense_Mutation_p.M4371L|PCLO_uc010lec.2_Missense_Mutation_p.M1336L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4302					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GCCATTCCCATTGGCTGGCCA	0.507			NA											7	64					0	0	0.00308	0	0
SEMA3D	223117	broad.mit.edu	37	7	84651811	84651811	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:84651811C>A	uc003uic.2	-	11	1350	c.1310G>T	c.(1309-1311)GGA>GTA	p.G437V	SEMA3D_uc010led.2_Missense_Mutation_p.G437V|SEMA3D_uc003uib.2_Missense_Mutation_p.G76V	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	437	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						GAACGTTGGTCCTCCTGCAAC	0.443	Ovarian(63;442 1191 17318 29975 31528)		NA											29	111					7.26314e-15	1.17538e-14	0.007291	1	0
ANKIB1	54467	broad.mit.edu	37	7	92000797	92000797	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:92000797G>C	uc003ulw.2	+	11	1869	c.1493G>C	c.(1492-1494)GGA>GCA	p.G498A	ANKIB1_uc010lew.1_5'UTR	NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	498							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAAGTTGTGGGAGTTAGTGAA	0.408			NA											7	9					0	0	0.001984	0	0
CCDC132	55610	broad.mit.edu	37	7	92923863	92923863	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:92923863G>T	uc003umo.2	+	14	1210	c.1082G>T	c.(1081-1083)AGT>ATT	p.S361I	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.S331I|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Missense_Mutation_p.S81I	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	361											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			TCAGAAGGGAGTAATATGATA	0.289			NA											12	104					3.27435e-08	4.63439e-08	0.00245	1	0
CCDC132	55610	broad.mit.edu	37	7	92970769	92970769	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:92970769A>T	uc003umo.2	+	23	2217	c.2089A>T	c.(2089-2091)ACA>TCA	p.T697S	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.T667S|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Missense_Mutation_p.T417S	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	697											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			TGCCACACTCACAGCAGCAGA	0.423			NA											8	52					0	0	0.006214	0	0
GNGT1	2792	broad.mit.edu	37	7	93536065	93536065	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:93536065G>T	uc003unc.1	+	2	155	c.7G>T	c.(7-9)GTA>TTA	p.V3L	GNGT1_uc003umx.1_RNA	NM_021955	NP_068774	P63211	GBG1_HUMAN	guanine nucleotide binding protein (G protein),	3					G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|signal transducer activity				0	all_cancers(62;2.39e-10)|all_epithelial(64;1.54e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			AAAGATGCCAGTAATCAATAT	0.413			NA											15	75					2.35188e-11	3.58741e-11	0.006122	1	0
TMEM130	222865	broad.mit.edu	37	7	98446204	98446204	+	Splice_Site	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:98446204A>G	uc003upo.2	-	7	1308	c.1119_splice	c.e7+1	p.E373_splice	TMEM130_uc011kiq.1_Splice_Site_p.E354_splice|TMEM130_uc011kir.1_Splice_Site_p.E373_splice|TMEM130_uc003upn.2_Splice_Site_p.E271_splice	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a							Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CTGAGTACCCACCTCCACCAT	0.557			NA											6	89					0	0	0.001168	0	0
LRCH4	4034	broad.mit.edu	37	7	100174741	100174741	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:100174741C>A	uc003uvj.2	-	12	1385	c.1332G>T	c.(1330-1332)GGG>GGT	p.G444G	LRCH4_uc010lgz.2_Intron|LRCH4_uc003uvi.2_RNA|LRCH4_uc011kjw.1_5'UTR|LRCH4_uc011kjx.1_RNA	NM_002319	NP_002310	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH)	444					nervous system development	PML body	protein binding			large_intestine(1)|ovary(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CGGCGGCGGCCCCTCCCACAA	0.617			NA											8	50					0.000442599	0.00050913	0.006214	1	0
ZAN	7455	broad.mit.edu	37	7	100364793	100364793	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:100364793G>T	uc003uwj.2	+	25	4938	c.4773G>T	c.(4771-4773)GGG>GGT	p.G1591G	ZAN_uc003uwk.2_Silent_p.G1591G|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Silent_p.G168G	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1591	Extracellular (Potential).|VWFD 2.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AGAACCGCGGGGGGATCCTGG	0.572			NA											5	29					1.23904e-05	1.57585e-05	0.000602	1	0
ZAN	7455	broad.mit.edu	37	7	100385713	100385713	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:100385713C>A	uc003uwj.2	+	39	7347	c.7182C>A	c.(7180-7182)ACC>ACA	p.T2394T	ZAN_uc003uwk.2_Silent_p.T2394T|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Silent_p.T444T	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2394	VWFD 4.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGATTACCACCGTCTACGGCT	0.607			NA											19	49					2.35188e-11	3.58741e-11	0.006122	1	0
RELN	5649	broad.mit.edu	37	7	103194238	103194238	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:103194238G>T	uc003vca.2	-	39	5998	c.5838C>A	c.(5836-5838)ATC>ATA	p.I1946I	RELN_uc010liz.2_Silent_p.I1946I	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1946					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TATTTCCATCGATAATGAAGT	0.363	NSCLC(146;835 1944 15585 22231 52158)		NA											15	66					2.32078e-09	3.40206e-09	0.003163	1	0
RELN	5649	broad.mit.edu	37	7	103363606	103363606	+	Silent	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:103363606A>G	uc003vca.2	-	8	946	c.786T>C	c.(784-786)TCT>TCC	p.S262S	RELN_uc010liz.2_Silent_p.S262S	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	262					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATTGGAGGACAGAAGCTGTTG	0.343	NSCLC(146;835 1944 15585 22231 52158)		NA											10	26					0	0	0.00245	0	0
LHFPL3	375612	broad.mit.edu	37	7	103969375	103969375	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:103969375G>A	uc003vce.2	+	1	272	c.148G>A	c.(148-150)GTC>ATC	p.V50I	LHFPL3_uc003vcf.2_Missense_Mutation_p.V50I	NM_199000	NP_945351	Q86UP9	LHPL3_HUMAN	lipoma HMGIC fusion partner-like 3	36	Helical; (Potential).					integral to membrane					0						CTTTGCCATCGTCAACGTGGT	0.617			NA											5	42					0	0	0.000602	0	0
MLL5	55904	broad.mit.edu	37	7	104749463	104749463	+	Silent	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:104749463C>G	uc003vcm.2	+	23	4077	c.3543C>G	c.(3541-3543)CTC>CTG	p.L1181L	MLL5_uc010ljc.2_Silent_p.L1181L|MLL5_uc010lje.1_RNA|MLL5_uc010ljf.1_RNA|MLL5_uc010ljg.2_5'UTR|uc003vcp.1_5'Flank|MLL5_uc010ljh.1_5'UTR	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1181					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						ACTTTCCACTCATTAGTGTAT	0.458			NA											4	47					0	0	0.009096	0	0
LMOD2	442721	broad.mit.edu	37	7	123296091	123296091	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:123296091T>C	uc003vky.2	+	1	231	c.74T>C	c.(73-75)CTG>CCG	p.L25P		NM_207163	NP_997046	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	25	Tropomyosin-binding (By similarity).|Potential.|Glu-rich.					cytoskeleton	actin binding|tropomyosin binding				0						CTCGCCTCCCTGTCAGCCGAG	0.532			NA											3	11					0	0	0.001168	0	0
GRM8	2918	broad.mit.edu	37	7	126173904	126173904	+	Missense_Mutation	SNP	T	T	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:126173904T>G	uc003vlr.2	-	8	1843	c.1532A>C	c.(1531-1533)CAC>CCC	p.H511P	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.H511P|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	511	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	AGACGCCGGGTGAGTATGTTC	0.493			NA								HNSCC(24;0.065)			5	73					0	0	0.001984	0	0
SMO	6608	broad.mit.edu	37	7	128846155	128846155	+	Missense_Mutation	SNP	T	T	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:128846155T>G	uc003vor.2	+	5	1365	c.1085T>G	c.(1084-1086)CTG>CGG	p.L362R	SMO_uc003vos.2_Missense_Mutation_p.L37R	NM_005631	NP_005622	Q99835	SMO_HUMAN	smoothened precursor	362	Helical; Name=4; (Potential).				adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(19)|large_intestine(10)|central_nervous_system(3)|upper_aerodigestive_tract(2)|biliary_tract(1)|lung(1)|liver(1)	37						TACTTCCACCTGCTCACCTGG	0.572			NA	Mis		skin basal cell 								34	100					0	0	0.002836	0	0
NRF1	4899	broad.mit.edu	37	7	129317534	129317534	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:129317534G>T	uc003voz.2	+	4	518	c.401G>T	c.(400-402)TGT>TTT	p.C134F	NRF1_uc003vpa.2_Missense_Mutation_p.C134F|NRF1_uc011kpa.1_5'UTR|NRF1_uc003vpb.2_Missense_Mutation_p.C134F	NM_005011	NP_005002	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	134					generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						ATTGTCCTCTGTATCTCACCC	0.413			NA											49	148					1.38658e-30	2.34912e-30	0.00361	1	0
NRF1	4899	broad.mit.edu	37	7	129350356	129350356	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:129350356C>A	uc003voz.2	+	7	1025	c.908C>A	c.(907-909)TCA>TAA	p.S303*	NRF1_uc003vpa.2_Nonsense_Mutation_p.S303*|NRF1_uc011kpa.1_Nonsense_Mutation_p.S142*|NRF1_uc003vpb.2_Nonsense_Mutation_p.S303*	NM_005011	NP_005002	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	303	Required for transcriptional activation.|				generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						CTTGTACCATCACAGACTGTA	0.468			NA											27	84					3.73148e-12	5.77963e-12	0.007291	1	0
ATP6V0A4	50617	broad.mit.edu	37	7	138394486	138394486	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:138394486C>A	uc003vuf.2	-	20	2550	c.2312G>T	c.(2311-2313)GGC>GTC	p.G771V	ATP6V0A4_uc003vug.2_Missense_Mutation_p.G771V|ATP6V0A4_uc003vuh.2_Missense_Mutation_p.G771V	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	771	Lumenal (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						TCCTCCCCAGCCTCGCGTCTG	0.493			NA											24	94					8.58068e-18	1.40879e-17	0.007291	1	0
CNTNAP2	26047	broad.mit.edu	37	7	147869430	147869430	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:147869430C>G	uc003weu.1	+	18	3386	c.2870C>G	c.(2869-2871)TCT>TGT	p.S957C		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	957	Laminin G-like 3.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AAGGTCACATCTGGGTTCATA	0.552			NA								HNSCC(39;0.1)			11	71					0	0	0.008291	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147926752	147926752	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:147926752C>T	uc003weu.1	+	20	3778	c.3262C>T	c.(3262-3264)CGA>TGA	p.R1088*		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	1088	Laminin G-like 4.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CTTACAGATTCGATACAACCT	0.443			NA								HNSCC(39;0.1)			9	55					0	0	0.006214	0	0
REPIN1	29803	broad.mit.edu	37	7	150069696	150069696	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:150069696G>A	uc010lpq.1	+	4	1855	c.1366G>A	c.(1366-1368)GAT>AAT	p.D456N	REPIN1_uc003whd.2_Missense_Mutation_p.D445N|REPIN1_uc010lpr.1_Missense_Mutation_p.D513N|REPIN1_uc003whc.2_Missense_Mutation_p.D456N|REPIN1_uc003whe.2_Missense_Mutation_p.D456N	NM_013400	NP_037532	Q9BWE0	REPI1_HUMAN	replication initiator 1 isoform 1	456					DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			pancreas(1)	1	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			CCACGCCCCCGATCGGCCCTT	0.731			NA											4	23					0	0	0.009096	0	0
ZNF775	285971	broad.mit.edu	37	7	150094415	150094415	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:150094415C>G	uc003whf.1	+	3	971	c.846C>G	c.(844-846)ATC>ATG	p.I282M		NM_173680	NP_775951	Q96BV0	ZN775_HUMAN	zinc finger protein 775	282	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.0173)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		gccAGTTCATCTGCAACGAGT	0.488			NA											3	18					0	0	0.009096	0	0
GIMAP8	155038	broad.mit.edu	37	7	150167962	150167962	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:150167962G>T	uc003whj.2	+	3	1012	c.682G>T	c.(682-684)GGC>TGC	p.G228C		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	228						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CAAGCCACAGGGTAAGTTGAT	0.378			NA											8	44					0.000274275	0.000318342	0.004482	1	0
GIMAP8	155038	broad.mit.edu	37	7	150174463	150174463	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:150174463G>A	uc003whj.2	+	5	1923	c.1593G>A	c.(1591-1593)GTG>GTA	p.V531V		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	531						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		TTGTCCTGGTGTTCCAGCTGG	0.493			NA											15	32					0	0	0.003163	0	0
GIMAP2	26157	broad.mit.edu	37	7	150389659	150389659	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:150389659G>A	uc003who.2	+	3	373	c.285G>A	c.(283-285)GTG>GTA	p.V95V	GIMAP1_uc003whp.2_Intron	NM_015660	NP_056475	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	95						integral to membrane	GTP binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		acaaagaggtgcagaggtgct	0.413			NA											7	37					0	0	0.001984	0	0
MLL3	58508	broad.mit.edu	37	7	151945153	151945153	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:151945153G>A	uc003wla.2	-	14	2585	c.2366C>T	c.(2365-2367)TCA>TTA	p.S789L		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	789					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AGGCAAGTCTGAAGAAGGTGT	0.433	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								31	385					0	0	0.002445	0	0
MLL3	58508	broad.mit.edu	37	7	151945231	151945231	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:151945231G>A	uc003wla.2	-	14	2507	c.2288C>T	c.(2287-2289)TCA>TTA	p.S763L		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	763					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TGTCTCAGATGATAACTTTAT	0.418	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								21	125					0	0	0.001882	0	0
MYOM2	9172	broad.mit.edu	37	8	2092729	2092729	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:2092729G>T	uc003wpx.3	+	37	4360	c.4222G>T	c.(4222-4224)GTG>TTG	p.V1408L	MYOM2_uc011kwi.1_Missense_Mutation_p.V833L	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	1408	Ig-like C2-type 5.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CATCAAAGGCGTGACCTCCGA	0.532			NA											9	40					2.17888e-05	2.74029e-05	0.006214	1	0
TEX15	56154	broad.mit.edu	37	8	30694318	30694318	+	Splice_Site	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:30694318C>A	uc003xil.2	-	3	8332	c.8332_splice	c.e3+1	p.A2778_splice		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15											ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GTGAAACTCACCATAAACCCA	0.373			NA											8	71					5.4927e-09	7.93586e-09	0.004482	1	0
HTRA4	203100	broad.mit.edu	37	8	38835503	38835503	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:38835503C>A	uc003xmj.2	+	4	918	c.803C>A	c.(802-804)TCA>TAA	p.S268*		NM_153692	NP_710159	P83105	HTRA4_HUMAN	HtrA serine peptidase 4 precursor	268	Serine protease.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity				0		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			CTGGGAAGATCATCTGACCTT	0.512			NA											12	99					1.15088e-07	1.59393e-07	0.004007	1	0
ANK1	286	broad.mit.edu	37	8	41572557	41572557	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:41572557G>A	uc003xok.2	-	15	1722	c.1638C>T	c.(1636-1638)TAC>TAT	p.Y546Y	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Silent_p.Y546Y|ANK1_uc003xoj.2_Silent_p.Y546Y|ANK1_uc003xol.2_Silent_p.Y546Y|ANK1_uc003xom.2_Silent_p.Y579Y	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	546	89 kDa domain.|ANK 16.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GCACCTTCCCGTACTTGGCCG	0.632			NA											7	76					0	0	0.006214	0	0
PRKDC	5591	broad.mit.edu	37	8	48719705	48719705	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:48719705C>A	uc003xqi.2	-	70	9797	c.9740G>T	c.(9739-9741)CGG>CTG	p.R3247L	PRKDC_uc003xqj.2_Missense_Mutation_p.R3247L|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3247	FAT.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CACCTGCTTCCGGGCACTGTC	0.448	Esophageal Squamous(79;1091 1253 12329 31680 40677)		NA						NHEJ					4	34					0.00909568	0.00978951	0.009096	1	0
PXDNL	137902	broad.mit.edu	37	8	52336217	52336217	+	Silent	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:52336217C>G	uc003xqu.3	-	14	1814	c.1713G>C	c.(1711-1713)GGG>GGC	p.G571G		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	571	Ig-like C2-type 4.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GGTCAGGGAACCCTGCGTCGT	0.483			NA											4	34					0	0	0.009096	0	0
ST18	9705	broad.mit.edu	37	8	53045828	53045828	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:53045828G>T	uc003xqz.2	-	15	2490	c.2334C>A	c.(2332-2334)CAC>CAA	p.H778Q	ST18_uc011ldq.1_Missense_Mutation_p.H425Q|ST18_uc011ldr.1_Missense_Mutation_p.H743Q|ST18_uc011lds.1_Missense_Mutation_p.H683Q|ST18_uc003xra.2_Missense_Mutation_p.H778Q	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	778	C2HC-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TTCCAGTCACGTGCCCCGAGC	0.517			NA											8	66					4.68919e-08	6.61615e-08	0.008291	1	0
ARFGEF1	10565	broad.mit.edu	37	8	68179364	68179364	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:68179364C>A	uc003xxo.1	-	12	2164	c.1774G>T	c.(1774-1776)GGA>TGA	p.G592*	ARFGEF1_uc003xxl.1_Nonsense_Mutation_p.G46*	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	592					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			CTGCCCCTTCCTTGAGCAATT	0.328			NA											12	71					1.5842e-08	2.24927e-08	0.001855	1	0
PRDM14	63978	broad.mit.edu	37	8	70978624	70978624	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:70978624C>A	uc003xym.2	-	5	1231	c.1029G>T	c.(1027-1029)CAG>CAT	p.Q343H		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	343	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			GCCCTTGACACTGCACAGCAA	0.458	NSCLC(129;99 1813 5906 40656 46114)		NA											18	96					0.00074312	0.000849415	0.006122	1	0
MSC	9242	broad.mit.edu	37	8	72754968	72754968	+	Silent	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:72754968C>T	uc003xyx.1	-	2	867	c.549G>A	c.(547-549)GTG>GTA	p.V183V	uc011lff.1_5'Flank|uc003xyy.2_5'Flank	NM_005098	NP_005089	O60682	MUSC_HUMAN	musculin	183					transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0	Breast(64;0.176)		Epithelial(68;0.137)|BRCA - Breast invasive adenocarcinoma(89;0.203)			TTCCCGAGACCACGAATGGCC	0.473			NA											39	371					0	0	0.002852	0	0
CA1	759	broad.mit.edu	37	8	86249255	86249255	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:86249255G>A	uc003ydh.2	-	5	473	c.273C>T	c.(271-273)CTC>CTT	p.L91L	CA13_uc003ydf.1_Intron|CA1_uc010mae.1_Silent_p.L91L|CA1_uc003ydi.2_Silent_p.L91L	NM_001738	NP_001729	P00915	CAH1_HUMAN	carbonic anhydrase I	91					one-carbon metabolic process	Golgi apparatus	carbonate dehydratase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(136;4.89e-06)			Acetazolamide(DB00819)|Amlodipine(DB00381)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dichlorphenamide(DB01144)|Ethinamate(DB01031)|Ethoxzolamide(DB00311)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Levetiracetam(DB01202)|Methazolamide(DB00703)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)|Verapamil(DB00661)|Zonisamide(DB00909)	GGAACTGAAAGAGCCTGTAGC	0.428			NA											5	68					0	0	0.000602	0	0
KIAA1429	25962	broad.mit.edu	37	8	95539232	95539232	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:95539232C>A	uc003ygo.1	-	8	1253	c.1240G>T	c.(1240-1242)GGG>TGG	p.G414W	KIAA1429_uc003ygp.2_Missense_Mutation_p.G414W|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	414					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TAGCTTAACCCTTTTATTATT	0.373			NA											7	102					0.000157383	0.00018675	0.00308	1	0
VPS13B	157680	broad.mit.edu	37	8	100789079	100789079	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:100789079G>A	uc003yiv.2	+	41	7510	c.7399G>A	c.(7399-7401)GTT>ATT	p.V2467I	VPS13B_uc003yiw.2_Missense_Mutation_p.V2442I	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2467					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTGTACCAGAGTTGACTCCTG	0.478	Colon(161;2205 2542 7338 31318)		NA											10	158					0	0	0.006214	0	0
RIMS2	9699	broad.mit.edu	37	8	104898002	104898002	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:104898002C>T	uc003yls.2	+	2	750	c.509C>T	c.(508-510)TCA>TTA	p.S170L	RIMS2_uc003ylp.2_Missense_Mutation_p.S392L|RIMS2_uc003ylw.2_Missense_Mutation_p.S200L|RIMS2_uc003ylq.2_Missense_Mutation_p.S200L|RIMS2_uc003ylr.2_Missense_Mutation_p.S200L	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	423					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GATCGACCATCAAGGCAAAGA	0.453			NA								HNSCC(12;0.0054)			9	35					0	0	0.004482	0	0
DPYS	1807	broad.mit.edu	37	8	105463629	105463629	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:105463629C>A	uc003yly.3	-	2	397	c.268G>T	c.(268-270)GCT>TCT	p.A90S		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	90					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CCTGAGAGAGCAGCCTGGAAT	0.448			NA											6	45					2.0095e-06	2.67637e-06	0.001984	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110451183	110451183	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:110451183T>C	uc003yne.2	+	32	3922	c.3818T>C	c.(3817-3819)ATG>ACG	p.M1273T		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1273	Extracellular (Potential).|IPT/TIG 6.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACACAAAACATGGCGGTGTAT	0.338			NA								HNSCC(38;0.096)			4	42					0	0	0.009096	0	0
RAD21	5885	broad.mit.edu	37	8	117870687	117870687	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:117870687C>A	uc003yod.2	-	5	673	c.385G>T	c.(385-387)GTG>TTG	p.V129L		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	129					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					TGCTGGGCCACATCGATGTCA	0.318			NA											15	144					2.23348e-06	2.96158e-06	0.004007	1	0
C8orf76	84933	broad.mit.edu	37	8	124251334	124251334	+	Silent	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:124251334G>C	uc003yqc.1	-	2	199	c.168C>G	c.(166-168)CTC>CTG	p.L56L	C8orf76_uc003yqd.2_Silent_p.L24L	NM_032847	NP_116236	Q96K31	CH076_HUMAN	hypothetical protein LOC84933	56							binding			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			TGAATTTCTTGAGAGTCAGCA	0.398			NA											7	180					0	0	0.004482	0	0
ASAP1	50807	broad.mit.edu	37	8	131104234	131104234	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:131104234C>A	uc003yta.1	-	24	2585	c.2557G>T	c.(2557-2559)GGC>TGC	p.G853C	ASAP1_uc003ysz.1_Missense_Mutation_p.G664C|ASAP1_uc011liw.1_Missense_Mutation_p.G846C	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	853	Pro-rich.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						GGAACTGCGCCTTTGTTTGGG	0.607			NA											25	188					2.20474e-14	3.52992e-14	0.003755	1	0
ADCY8	114	broad.mit.edu	37	8	131792956	131792956	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:131792956C>T	uc003ytd.3	-	18	3692	c.3436G>A	c.(3436-3438)GCC>ACC	p.A1146T	ADCY8_uc010mds.2_Missense_Mutation_p.A1015T	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	1146	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TAATCAAAGGCAAAGCCCTGG	0.502			NA								HNSCC(32;0.087)			17	138					0	0	0.00499	0	0
TG	7038	broad.mit.edu	37	8	134145810	134145810	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:134145810G>C	uc003ytw.2	+	47	8135	c.8094G>C	c.(8092-8094)AAG>AAC	p.K2698N	TG_uc010mdw.2_Missense_Mutation_p.K1457N|TG_uc011ljb.1_Missense_Mutation_p.K1067N|TG_uc011ljc.1_Missense_Mutation_p.K831N	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2698					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGAACTACAAGGAGTTCAGTG	0.527			NA											7	54					0	0	0.00308	0	0
ZFAT	57623	broad.mit.edu	37	8	135614084	135614084	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:135614084C>A	uc003yup.2	-	6	2053	c.1878G>T	c.(1876-1878)ACG>ACT	p.T626T	ZFAT_uc003yun.2_Silent_p.T614T|ZFAT_uc003yuo.2_Silent_p.T614T|ZFAT_uc010meh.2_Silent_p.T614T|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Silent_p.T614T|ZFAT_uc010mej.2_Silent_p.T564T|ZFAT_uc003yur.2_Silent_p.T614T	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	626					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			CTTCACCTTGCGTCTGGACTG	0.542			NA											10	80					2.80697e-09	4.09483e-09	0.000978	1	0
FAM135B	51059	broad.mit.edu	37	8	139163754	139163754	+	Silent	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:139163754A>T	uc003yuy.2	-	13	3135	c.2964T>A	c.(2962-2964)ACT>ACA	p.T988T	FAM135B_uc003yux.2_Silent_p.T889T|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Silent_p.T550T|FAM135B_uc003yvb.2_Silent_p.T550T	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	988										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AATGGGTCACAGTGGGGCACA	0.498			NA								HNSCC(54;0.14)			4	84					0	0	0.009096	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141231580	141231580	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:141231580G>C	uc003yvj.2	-	17	2668	c.2534C>G	c.(2533-2535)GCA>GGA	p.A845G	TRAPPC9_uc003yvh.2_Missense_Mutation_p.A943G|TRAPPC9_uc010mel.1_Missense_Mutation_p.A266G|TRAPPC9_uc003yvi.1_Missense_Mutation_p.A836G	NM_001160372	NP_001153844	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9 isoform	845					cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2						GTAGTCGCCTGCTTTGTTGCT	0.587			NA											10	71					0	0	0.000978	0	0
EIF2C2	27161	broad.mit.edu	37	8	141545586	141545586	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:141545586C>A	uc003yvn.2	-	17	2292	c.2252G>T	c.(2251-2253)TGT>TTT	p.C751F	EIF2C2_uc010men.2_Missense_Mutation_p.C674F|EIF2C2_uc010meo.2_Intron	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	751	Piwi.				mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			AGCGTGACTACACAGGTAGAA	0.562			NA											9	68					7.48243e-07	1.00996e-06	0.006214	1	0
SLC45A4	57210	broad.mit.edu	37	8	142228200	142228200	+	Silent	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:142228200G>C	uc003ywd.1	-	4	1694	c.1386C>G	c.(1384-1386)CTC>CTG	p.L462L	SLC45A4_uc003ywc.1_Silent_p.L462L|SLC45A4_uc010meq.1_Silent_p.L460L	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	513					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GGAGGTGGCAGAGGCACAGCC	0.642			NA											3	30					0	0	0.004672	0	0
SCRIB	23513	broad.mit.edu	37	8	144874231	144874231	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr8:144874231C>A	uc003yzp.1	-	33	4594	c.4587G>T	c.(4585-4587)ACG>ACT	p.T1529T	SCRIB_uc003yzn.1_Silent_p.T262T|SCRIB_uc003yzo.1_Silent_p.T1529T	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	1529					activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GGGGCCCCCGCGTGCCCCGGC	0.697	Pancreas(51;966 1133 10533 14576 29674)		NA											3	6					0.004672	0.00509519	0.004672	1	0
RANBP6	26953	broad.mit.edu	37	9	6012421	6012421	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:6012421C>A	uc003zjr.2	-	1	3198	c.3187G>T	c.(3187-3189)GAT>TAT	p.D1063Y	RANBP6_uc011lmf.1_Missense_Mutation_p.D711Y|RANBP6_uc003zjs.2_Missense_Mutation_p.D651Y	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	1063					protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		GCACAAGGATCCTCATAGTTA	0.378			NA											13	54					7.03913e-09	1.01055e-08	0.001368	1	0
PTPRD	5789	broad.mit.edu	37	9	8507349	8507349	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:8507349G>A	uc003zkk.2	-	21	2340	c.1629C>T	c.(1627-1629)ACC>ACT	p.T543T	PTPRD_uc003zkp.2_Silent_p.T543T|PTPRD_uc003zkq.2_Silent_p.T543T|PTPRD_uc003zkr.2_Silent_p.T537T|PTPRD_uc003zks.2_Silent_p.T533T|PTPRD_uc003zkl.2_Silent_p.T543T|PTPRD_uc003zkm.2_Silent_p.T530T|PTPRD_uc003zkn.2_Silent_p.T543T|PTPRD_uc003zko.2_Silent_p.T540T	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	543	Fibronectin type-III 3.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AGTTGGCAATGGTATCTGAAC	0.463			NA								TSP Lung(15;0.13)			21	132					0	0	0.001882	0	0
MPDZ	8777	broad.mit.edu	37	9	13137969	13137969	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:13137969T>A	uc010mia.1	-	28	4244	c.4187A>T	c.(4186-4188)GAT>GTT	p.D1396V	MPDZ_uc003zky.3_5'Flank|MPDZ_uc010mib.2_Missense_Mutation_p.D101V|MPDZ_uc010mhx.2_Missense_Mutation_p.D218V|MPDZ_uc011lmm.1_Missense_Mutation_p.D255V|MPDZ_uc003zkz.3_Missense_Mutation_p.D89V|MPDZ_uc010mhy.2_Missense_Mutation_p.D1396V|MPDZ_uc010mhz.2_Missense_Mutation_p.D1363V|MPDZ_uc011lmn.1_Missense_Mutation_p.D1363V|MPDZ_uc003zlb.3_Missense_Mutation_p.D1396V	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1396	PDZ 8.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		TAGAAGCTCATCTGCAATTTG	0.393			NA											4	45					0	0	0.000602	0	0
PLIN2	123	broad.mit.edu	37	9	19116449	19116449	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:19116449G>A	uc003zno.2	-	8	1290	c.1111C>T	c.(1111-1113)CTC>TTC	p.L371F	PLIN2_uc011lna.1_Missense_Mutation_p.L343F	NM_001122	NP_001113	Q99541	PLIN2_HUMAN	adipose differentiation-related protein	371					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle				ovary(2)	2						CTAGAAGTGAGGAGGCTGTCA	0.498			NA											13	56					0	0	0.001368	0	0
KLHL9	55958	broad.mit.edu	37	9	21334826	21334826	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:21334826G>A	uc003zoy.2	-	1	604	c.33C>T	c.(31-33)GGC>GGT	p.G11G	KLHL9_uc003zow.2_Intron|KLHL9_uc003zox.2_RNA	NM_018847	NP_061335	Q9P2J3	KLHL9_HUMAN	kelch-like 9	11					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|midbody				ovary(3)|skin(1)	4				Lung(24;8.52e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.118)		GGGCAGAGACGCCCATTTCGC	0.463			NA											13	52					0	0	0.001855	0	0
TEK	7010	broad.mit.edu	37	9	27183579	27183579	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:27183579C>A	uc003zqi.3	+	8	1595	c.1153C>A	c.(1153-1155)CTG>ATG	p.L385M	TEK_uc011lnn.1_3'UTR|TEK_uc011lno.1_Missense_Mutation_p.L342M|TEK_uc011lnp.1_Missense_Mutation_p.L238M|TEK_uc003zqj.1_Missense_Mutation_p.L319M	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	385	Extracellular (Potential).|Ig-like C2-type 2.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		AGAAATGACCCTGGTGAAGCC	0.428			NA											35	174					8.73648e-17	1.42401e-16	0.004289	1	0
DDX58	23586	broad.mit.edu	37	9	32492480	32492480	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:32492480G>A	uc003zra.2	-	4	638	c.480C>T	c.(478-480)CTC>CTT	p.L160L	DDX58_uc010mjj.2_Intron|DDX58_uc010mjk.1_Silent_p.L115L|DDX58_uc011lnr.1_Intron|DDX58_uc010mji.2_Silent_p.L89L	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	160	CARD 2.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		TGTCTGATCTGAGAAGGCATT	0.398			NA											23	94					0	0	0.002299	0	0
TAF1L	138474	broad.mit.edu	37	9	32632339	32632339	+	Missense_Mutation	SNP	C	C	T	rs145748175	by1000genomes	TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:32632339C>T	uc003zrg.1	-	1	3329	c.3239G>A	c.(3238-3240)CGT>CAT	p.R1080H	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1080					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CTCTTTGTAACGCTCTTGATG	0.473			NA											21	114					0	0	0.001882	0	0
DCAF12	25853	broad.mit.edu	37	9	34126386	34126386	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:34126386G>A	uc003ztt.2	-	1	386	c.44C>T	c.(43-45)TCG>TTG	p.S15L		NM_015397	NP_056212	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	15						centrosome|CUL4 RING ubiquitin ligase complex					0						AGCTCCCGGCGAGGCGGGCGC	0.692			NA											4	29					0	0	0.000602	0	0
TLN1	7094	broad.mit.edu	37	9	35704723	35704723	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:35704723G>A	uc003zxt.2	-	44	6177	c.5823C>T	c.(5821-5823)CCC>CCT	p.P1941P		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	1941	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AGGCATCACTGGGGCTGCACT	0.592			NA											10	64					0	0	0.006214	0	0
ALDH1A1	216	broad.mit.edu	37	9	75526984	75526984	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:75526984C>G	uc004ajd.2	-	10	1143	c.1090G>C	c.(1090-1092)GAA>CAA	p.E364Q	ALDH1A1_uc011lsh.1_Missense_Mutation_p.E285Q|ALDH1A1_uc011lsg.1_Missense_Mutation_p.E190Q	NM_000689	NP_000680	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1A1	364					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			ovary(3)|lung(1)	4					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TTGGCCCCTTCTTTCTTCCCA	0.408			NA											28	76					0	0	0.00632	0	0
FRMD3	257019	broad.mit.edu	37	9	85950546	85950546	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:85950546C>A	uc004ams.1	-	6	683	c.481G>T	c.(481-483)GGT>TGT	p.G161C	FRMD3_uc004amr.1_Missense_Mutation_p.G147C	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	161	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						TCGTAATCACCAAGCTCAGCT	0.398			NA											8	26					1.06961e-07	1.48823e-07	0.00308	1	0
FAM75C1	441452	broad.mit.edu	37	9	90538003	90538003	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:90538003C>A	uc010mqi.2	+	4	3210	c.3181C>A	c.(3181-3183)CTC>ATC	p.L1061I	FAM75C1_uc004apq.3_Missense_Mutation_p.L1044I	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						AGCTGAGAGGCTCATGACAGC	0.498			NA											5	55					0.00116845	0.00131559	0.001168	1	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112705113	112705113	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:112705113G>T	uc004bei.2	+	7	836	c.644G>T	c.(643-645)CGC>CTC	p.R215L	PALM2_uc004bef.2_Missense_Mutation_p.R217L|PALM2_uc004beg.2_Missense_Mutation_p.R183L|PALM2_uc004beh.3_Missense_Mutation_p.R215L|PALM2-AKAP2_uc004bek.3_Intron|PALM2-AKAP2_uc004bej.3_Intron|PALM2-AKAP2_uc004bel.1_Intron	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	481							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						TATGAGGTGCGCTCAGGAGGC	0.468			NA											6	24					8.12818e-05	9.7994e-05	0.001984	1	0
SVEP1	79987	broad.mit.edu	37	9	113173599	113173599	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:113173599T>A	uc010mtz.2	-	37	6729	c.6392A>T	c.(6391-6393)CAG>CTG	p.Q2131L	SVEP1_uc010mty.2_Missense_Mutation_p.Q57L	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2131	Sushi 12.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						AGGGTTCCACTGCCCACCTCT	0.478			NA											11	33					0	0	0.001368	0	0
COL27A1	85301	broad.mit.edu	37	9	117033025	117033025	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:117033025G>T	uc011lxl.1	+	36	3573	c.3573G>T	c.(3571-3573)GAG>GAT	p.E1191D	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1191	Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						CAGGCCTTGAGGGTGACAGTG	0.612			NA											8	47					0.000442599	0.00050913	0.006214	1	0
TRAF1	7185	broad.mit.edu	37	9	123675735	123675735	+	Silent	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:123675735C>G	uc004bku.1	-	5	1148	c.576G>C	c.(574-576)GGG>GGC	p.G192G	TRAF1_uc011lyg.1_Silent_p.G70G|TRAF1_uc010mvl.1_Silent_p.G192G	NM_005658	NP_005649	Q13077	TRAF1_HUMAN	TNF receptor-associated factor 1	192					apoptosis|positive regulation of NF-kappaB transcription factor activity|protein complex assembly|regulation of apoptosis|signal transduction	cytoplasm	protein binding|zinc ion binding			skin(2)|ovary(1)	3						CACGCAGCTTCCCCTCCAGCT	0.612			NA											7	42					0	0	0.001984	0	0
OR1J2	26740	broad.mit.edu	37	9	125273228	125273228	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:125273228C>A	uc004bmj.1	+	4	1003	c.148C>A	c.(148-150)CAG>AAG	p.Q50K	OR1J2_uc011lyv.1_Missense_Mutation_p.Q50K	NM_054107	NP_473448	Q8NGS2	OR1J2_HUMAN	olfactory receptor, family 1, subfamily J,	50	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|pancreas(1)|breast(1)	5						GCTGCTCATCCAGCTGGACTC	0.557			NA											40	123					1.48646e-12	2.32228e-12	0.002522	1	0
TTF1	7270	broad.mit.edu	37	9	135266129	135266129	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:135266129C>G	uc004cbl.2	-	7	2129	c.2077G>C	c.(2077-2079)GAG>CAG	p.E693Q	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Missense_Mutation_p.E178Q	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	693	Myb-like 2.				negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		TCTTTTAACTCCTGGGGAGAC	0.413			NA											33	141					0	0	0.003271	0	0
COL5A1	1289	broad.mit.edu	37	9	137688239	137688239	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:137688239G>T	uc004cfe.2	+	35	3201	c.2819G>T	c.(2818-2820)GGC>GTC	p.G940V		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	940	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GGAGGTGACGGCCCAGCTGGC	0.572			NA											13	68					4.7546e-09	6.8915e-09	0.004007	1	0
OLFM1	10439	broad.mit.edu	37	9	137998651	137998651	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr9:137998651A>T	uc010nar.2	+	5	1049	c.733A>T	c.(733-735)AGG>TGG	p.R245W	OLFM1_uc004cfl.3_Missense_Mutation_p.R227W|OLFM1_uc004cfn.3_5'UTR	NM_014279	NP_055094	Q99784	NOE1_HUMAN	olfactomedin related ER localized protein	245	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		CTCCGGCTCGAGGTTCGGATC	0.562			NA											5	16					0	0	0.000602	0	0
MXRA5	25878	broad.mit.edu	37	X	3235848	3235848	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:3235848C>A	uc004crg.3	-	6	6031	c.5874G>T	c.(5872-5874)CAG>CAT	p.Q1958H		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1958	Ig-like C2-type 4.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CAGTGACGTCCTGGTAGTGGG	0.572			NA											9	37					0.00448238	0.00490617	0.004482	1	0
WWC3	55841	broad.mit.edu	37	X	10109514	10109514	+	Silent	SNP	A	A	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:10109514A>C	uc004csx.3	+	23	3450	c.3252A>C	c.(3250-3252)ATA>ATC	p.I1084I	WWC3_uc010nds.2_Silent_p.I748I|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	1084										ovary(4)	4						GGATCAACATACCTCCTCTCC	0.458			NA											4	56					0	0	0.001168	0	0
YY2	404281	broad.mit.edu	37	X	21863482	21863482	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:21863482G>C	uc010nfq.2	+	3	615	c.418G>C	c.(418-420)GAA>CAA	p.E140Q	MBTPS2_uc004dae.2_Missense_Mutation_p.E140Q|MBTPS2_uc004dab.2_Missense_Mutation_p.E140Q	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						GCTTCACAATGAACAGGTGTT	0.224			NA											3	23					0	0	0.009096	0	0
PHEX	5251	broad.mit.edu	37	X	22112124	22112124	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:22112124C>A	uc004dah.2	+	7	959	c.756C>A	c.(754-756)TTC>TTA	p.F252L	PHEX_uc011mjr.1_Missense_Mutation_p.F252L|PHEX_uc011mjs.1_Missense_Mutation_p.F155L	NM_000444	NP_000435	P78562	PHEX_HUMAN	phosphate-regulating neutral endopeptidase	252	Extracellular (Potential).		F -> S (in HYP).		biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3						TTTACAAGTTCATGGTGGATA	0.413			NA											28	154					3.73988e-18	6.17388e-18	0.00632	1	0
MAGEB6	158809	broad.mit.edu	37	X	26212996	26212996	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:26212996C>T	uc004dbr.2	+	2	1182	c.1033C>T	c.(1033-1035)CGG>TGG	p.R345W	MAGEB6_uc010ngc.1_Missense_Mutation_p.R125W	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	345	MAGE.									ovary(3)	3						CGTGGTTTACCGGCAGGTGTG	0.498			NA											19	112					0	0	0.00278	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254210	30254210	+	Silent	SNP	A	A	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:30254210A>C	uc004dca.1	+	5	906	c.169A>C	c.(169-171)AGG>CGG	p.R57R		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	57											0						GTCTGCTGGTAGGTCACGTAG	0.438			NA											6	28					0	0	0.00308	0	0
FAM47B	170062	broad.mit.edu	37	X	34962493	34962493	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:34962493C>A	uc004ddi.1	+	1	1563	c.1545C>A	c.(1543-1545)GAC>GAA	p.D515E		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	515										ovary(3)|breast(1)	4						TGGAGCTAGACGACATGGATG	0.493			NA											15	67					0.00400662	0.00441217	0.004007	1	0
CXorf59	286464	broad.mit.edu	37	X	36091444	36091444	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:36091444G>T	uc004ddk.1	+	4	565	c.379G>T	c.(379-381)GGA>TGA	p.G127*		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	127						integral to membrane		p.G127*(1)		central_nervous_system(1)	1						CTGGCCTGAAGGACCCCATTC	0.388			NA											17	64					1.00905e-13	1.607e-13	0.008871	1	0
FAM47C	442444	broad.mit.edu	37	X	37029546	37029546	+	Silent	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:37029546T>A	uc004ddl.1	+	1	3077	c.3063T>A	c.(3061-3063)GTT>GTA	p.V1021V		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	1021										ovary(3)	3						CAATGCAAGTTTACAAGTACA	0.398			NA											27	137					0	0	0.002836	0	0
ZC3H12B	340554	broad.mit.edu	37	X	64709219	64709219	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:64709219C>A	uc010nko.2	+	1	514	c.505C>A	c.(505-507)CTT>ATT	p.L169I		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	169							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						TGAATTGTCTCTTGAAGATGA	0.443			NA											16	114					4.14922e-12	6.41566e-12	0.004007	1	0
HEPH	9843	broad.mit.edu	37	X	65480010	65480010	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:65480010G>A	uc011moz.1	+	19	3174	c.3114G>A	c.(3112-3114)GTG>GTA	p.V1038V	HEPH_uc004dwn.2_Silent_p.V1038V|HEPH_uc004dwo.2_Silent_p.V768V|HEPH_uc010nkr.2_Silent_p.V846V|HEPH_uc011mpa.1_Silent_p.V1038V	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	1035	Extracellular (Potential).|Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						TGGAGATGGTGGCCAGCAACC	0.527			NA											12	44					0	0	0.001368	0	0
HEPH	9843	broad.mit.edu	37	X	65480070	65480070	+	Silent	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:65480070C>A	uc011moz.1	+	19	3234	c.3174C>A	c.(3172-3174)GGC>GGA	p.G1058G	HEPH_uc004dwn.2_Silent_p.G1058G|HEPH_uc004dwo.2_Silent_p.G788G|HEPH_uc010nkr.2_Silent_p.G866G|HEPH_uc011mpa.1_Silent_p.G1058G	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	1055	Extracellular (Potential).|Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						TCCATGCTGGCATGGAGACCC	0.483			NA											12	31					0.000151284	0.000180462	0.001855	1	0
KIAA2022	340533	broad.mit.edu	37	X	73962057	73962057	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:73962057C>A	uc004eby.2	-	3	2952	c.2335G>T	c.(2335-2337)GCA>TCA	p.A779S		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	779					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GCAGCCTTTGCCTCATGAAAT	0.408			NA											22	101					1.22574e-08	1.75411e-08	0.002299	1	0
ZCCHC5	203430	broad.mit.edu	37	X	77912982	77912982	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:77912982G>T	uc004edc.1	-	2	1232	c.936C>A	c.(934-936)CTC>CTA	p.L312L		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	312							nucleic acid binding|zinc ion binding			ovary(1)	1						AAGTATCCTGGAGCACAGGTA	0.478			NA											3	17					0.004672	0.00509519	0.004672	1	0
LPAR4	2846	broad.mit.edu	37	X	78011436	78011436	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:78011436C>A	uc010nme.2	+	2	1475	c.1070C>A	c.(1069-1071)ACA>AAA	p.T357K		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	357	Cytoplasmic (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						AGTGATCAAACAACAAATAAT	0.393			NA											15	82					6.31663e-08	8.84328e-08	0.003163	1	0
CENPI	2491	broad.mit.edu	37	X	100356187	100356187	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:100356187C>T	uc004egx.2	+	2	398	c.128C>T	c.(127-129)TCA>TTA	p.S43L	CENPI_uc011mrg.1_Missense_Mutation_p.S43L|CENPI_uc004egy.2_Missense_Mutation_p.S43L	NM_006733	NP_006724	Q92674	CENPI_HUMAN	centromere protein I	43					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1						AAGAACATCTCAAAACATGGA	0.423			NA											15	119					0	0	0.004007	0	0
NRK	203447	broad.mit.edu	37	X	105190361	105190361	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:105190361G>C	uc004emd.2	+	26	4561	c.4258G>C	c.(4258-4260)GAA>CAA	p.E1420Q	NRK_uc011msi.1_5'Flank	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	1420	CNH.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						TATTGGTTCTGAAAAAAGACT	0.393			NA								HNSCC(51;0.14)			6	44					0	0	0.001168	0	0
LAMP2	3920	broad.mit.edu	37	X	119575692	119575692	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:119575692T>A	uc004est.3	-	8	1166	c.986A>T	c.(985-987)TAT>TTT	p.Y329F	LAMP2_uc004ess.3_Missense_Mutation_p.Y329F|LAMP2_uc011mtz.1_Missense_Mutation_p.Y218F|LAMP2_uc011mua.1_Missense_Mutation_p.Y282F|LAMP2_uc010nqp.1_Missense_Mutation_p.Y329F	NM_002294	NP_002285	P13473	LAMP2_HUMAN	lysosomal-associated membrane protein 2 isoform	329	Lumenal (Potential).|Second lumenal domain.				platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				ovary(1)	1						GTTGCACATATAAGAACTTCC	0.388			NA											20	114					0	0	0.001882	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125298989	125298989	+	Silent	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:125298989G>T	uc004euk.1	-	1	946	c.919C>A	c.(919-921)CGA>AGA	p.R307R		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	307										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						ACATTCTCTCGGCAGTAGGGC	0.607			NA											26	140					1.7881e-09	2.62546e-09	0.008361	1	0
ARHGAP36	158763	broad.mit.edu	37	X	130218994	130218994	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:130218994C>A	uc004evz.2	+	7	1256	c.911C>A	c.(910-912)TCT>TAT	p.S304Y	ARHGAP36_uc004ewa.2_Missense_Mutation_p.S292Y|ARHGAP36_uc004ewb.2_Missense_Mutation_p.S273Y|ARHGAP36_uc004ewc.2_Missense_Mutation_p.S168Y	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	304	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						ATGAAGGATTCTCTGCTGCCA	0.463			NA											12	116					7.03913e-09	1.01055e-08	0.001368	1	0
IGSF1	3547	broad.mit.edu	37	X	130417006	130417006	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:130417006G>A	uc004ewd.2	-	6	1138	c.900C>T	c.(898-900)GAC>GAT	p.D300D	IGSF1_uc004ewe.3_Silent_p.D289D|IGSF1_uc004ewf.2_Silent_p.D280D	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	300	Ig-like C2-type 3.|Extracellular (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						TATATGATGCGTCATAGTAAA	0.388			NA											17	100					0	0	0.00499	0	0
GPR112	139378	broad.mit.edu	37	X	135430934	135430934	+	Missense_Mutation	SNP	C	C	T	rs141778568	byFrequency	TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:135430934C>T	uc004ezu.1	+	6	5360	c.5069C>T	c.(5068-5070)TCC>TTC	p.S1690F	GPR112_uc010nsb.1_Missense_Mutation_p.S1485F|GPR112_uc010nsc.1_Missense_Mutation_p.S1457F	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1690	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					GCTATTTCCTCCATTCCAAAG	0.448			NA											45	146					0	0	0.009718	0	0
GPR112	139378	broad.mit.edu	37	X	135455157	135455157	+	Silent	SNP	G	G	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:135455157G>A	uc004ezu.1	+	15	8001	c.7710G>A	c.(7708-7710)CGG>CGA	p.R2570R	GPR112_uc010nsb.1_Silent_p.R2365R	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2570	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CTGTGCTGCGGGGGGACCACA	0.537			NA											48	321					0	0	0.00361	0	0
MCF2	4168	broad.mit.edu	37	X	138713553	138713553	+	Splice_Site	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:138713553C>A	uc004fau.2	-	3	582	c.288_splice	c.e3+1	p.N96_splice	MCF2_uc004fav.2_Splice_Site_p.N96_splice|MCF2_uc011mwl.1_Intron|MCF2_uc010nsh.1_Splice_Site_p.N96_splice|MCF2_uc011mwm.1_Intron|MCF2_uc011mwn.1_Splice_Site_p.N241_splice|MCF2_uc004faw.2_Splice_Site_p.N156_splice|MCF2_uc011mwo.1_Splice_Site_p.N156_splice	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					AGACAACATACATTTCTGAAG	0.358			NA											35	138					3.2961e-07	4.54408e-07	0.004878	1	0
MAGEC3	139081	broad.mit.edu	37	X	140969466	140969466	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:140969466A>G	uc011mwp.1	+	4	793	c.793A>G	c.(793-795)AGT>GGT	p.S265G		NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	265	MAGE 1.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GGGGAGTCTGAGTGATGAGCA	0.478			NA											4	204					0	0	0.009096	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995831	140995831	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:140995831T>C	uc004fbt.2	+	4	2927	c.2641T>C	c.(2641-2643)TCC>CCC	p.S881P	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	881							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					ATATACAAGTTCCTCAGACAC	0.488			NA								HNSCC(15;0.026)			41	215					0	0	0.00361	0	0
MAGEA8	4107	broad.mit.edu	37	X	149013559	149013559	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:149013559A>T	uc004fdw.1	+	3	728	c.513A>T	c.(511-513)GAA>GAT	p.E171D		NM_005364	NP_005355	P43361	MAGA8_HUMAN	melanoma antigen family A, 8	171	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					ATGTGAAGGAAGTGGACCCTG	0.522			NA											8	62					0	0	0.006214	0	0
MAGEA6	4105	broad.mit.edu	37	X	151869542	151869542	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:151869542C>A	uc004ffq.1	+	3	426	c.232C>A	c.(232-234)CCT>ACT	p.P78T	MAGEA6_uc004ffr.1_Missense_Mutation_p.P78T|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	78							protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					CATGAACTACCCTCTCTGGAG	0.587			NA											6	61					2.74318e-10	4.11477e-10	0.006214	1	0
AVPR2	554	broad.mit.edu	37	X	153171639	153171639	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:153171639C>G	uc004fjh.3	+	2	750	c.679C>G	c.(679-681)CTC>GTC	p.L227V	AVPR2_uc004fjg.3_Missense_Mutation_p.L16V|AVPR2_uc004fji.2_Missense_Mutation_p.L227V	NM_000054	NP_000045	P30518	V2R_HUMAN	arginine vasopressin receptor 2 isoform 1	227	Cytoplasmic (Potential).				activation of adenylate cyclase activity|excretion|G-protein signaling, coupled to cAMP nucleotide second messenger|hemostasis|positive regulation of gene expression|transmembrane transport|water transport	endoplasmic reticulum|endosome|Golgi apparatus|integral to plasma membrane	vasopressin receptor activity			breast(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Conivaptan(DB00872)|Terlipressin(DB02638)|Vasopressin(DB00067)	CTGCCAGGTGCTCATCTTCCG	0.682			NA											8	57					0	0	0.008291	0	0
IL9R	3581	broad.mit.edu	37	X	155239571	155239571	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:155239571G>T	uc004fnv.1	+	9	1242	c.1063G>T	c.(1063-1065)GCC>TCC	p.A355S	IL9R_uc004fnu.1_3'UTR	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	355	Cytoplasmic (Potential).				cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CGTCCAGGAGGCCACTGCACT	0.667			NA											7	92					8.12818e-05	9.7994e-05	0.001984	1	0
OR8H3	390152	broad.mit.edu	37	11	55890477	55890477	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr11:55890477delC	uc001nii.1	+	1	629	c.629delC	c.(628-630)TCCfs	p.S210fs		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					CTGATGGTGTCCCTTATCACA	0.423			NA											13	179	---	---	---	---	NA	NA	NA	NA	NA
SLC2A3	6515	broad.mit.edu	37	12	8075436	8075437	+	Frame_Shift_Ins	INS	-	-	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:8075436_8075437insT	uc001qtr.2	-	9	1514_1515	c.1252_1253insA	c.(1252-1254)TTGfs	p.L418fs		NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	418	Helical; Name=11; (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		GGGGAAGAGCAATCCGACTAGG	0.51	Colon(96;424 1461 14416 20933 23688)		NA											33	97	---	---	---	---	NA	NA	NA	NA	NA
MYO1A	4640	broad.mit.edu	37	12	57422572	57422573	+	Frame_Shift_Ins	INS	-	-	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr12:57422572_57422573insT	uc001smw.3	-	28	3341_3342	c.3098_3099insA	c.(3097-3099)AAGfs	p.K1033fs	MYO1A_uc010sqz.1_Frame_Shift_Ins_p.K871fs|MYO1A_uc009zpd.2_Frame_Shift_Ins_p.K1033fs	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	1033					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7						AATGACTCCCCTTTTTTTTGTA	0.559			NA											7	146	---	---	---	---	NA	NA	NA	NA	NA
GRHL1	29841	broad.mit.edu	37	2	10136084	10136090	+	Frame_Shift_Del	DEL	AAGAACC	AAGAACC	-			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	AAGAACC	AAGAACC	-	-	AAGAACC	AAGAACC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:10136084_10136090delAAGAACC	uc002raa.2	+	13	1748_1754	c.1577_1583delAAGAACC	c.(1576-1584)GAAGAACCAfs	p.E526fs	GRHL1_uc002rab.2_RNA|GRHL1_uc002rad.2_Frame_Shift_Del_p.E337fs|GRHL1_uc010yjb.1_Frame_Shift_Del_p.E375fs	NM_198182	NP_937825	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1	526_528					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		GCCCGGATAGAAGAACCAAAGAGAGGT	0.449			NA											25	186	---	---	---	---	NA	NA	NA	NA	NA
TTN	7273	broad.mit.edu	37	2	179395922	179395931	+	Frame_Shift_Del	DEL	GACGGTCATG	GACGGTCATG	-			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	GACGGTCATG	GACGGTCATG	-	-	GACGGTCATG	GACGGTCATG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:179395922_179395931delGACGGTCATG	uc010zfg.1	-	307	97931_97940	c.97707_97716delCATGACCGTC	c.(97705-97716)TCCATGACCGTCfs	p.S32569fs	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Frame_Shift_Del_p.S26264fs|TTN_uc010zfi.1_Frame_Shift_Del_p.S26197fs|TTN_uc010zfj.1_Frame_Shift_Del_p.S26072fs|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33496_33499							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGCCCTCGTAGACGGTCATGGACCGTGGCT	0.481			NA											28	191	---	---	---	---	NA	NA	NA	NA	NA
TRIP12	9320	broad.mit.edu	37	2	230661474	230661475	+	Frame_Shift_Ins	INS	-	-	A			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr2:230661474_230661475insA	uc002vpw.1	-	24	3532_3533	c.3423_3424insT	c.(3421-3426)CTTGTAfs	p.L1141fs	TRIP12_uc002vpx.1_Frame_Shift_Ins_p.L1189fs|TRIP12_uc002vpy.1_Frame_Shift_Ins_p.L871fs|TRIP12_uc010zlz.1_RNA	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1141_1142					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CGGATTTCTACAAGGCACTCAG	0.361			NA											8	84	---	---	---	---	NA	NA	NA	NA	NA
SLC23A2	9962	broad.mit.edu	37	20	4850569	4850569	+	Frame_Shift_Del	DEL	G	G	-	rs138961929		TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:4850569delG	uc002wlg.1	-	12	1608	c.1233delC	c.(1231-1233)CCCfs	p.P411fs	SLC23A2_uc010zqr.1_Frame_Shift_Del_p.P296fs|SLC23A2_uc002wlh.1_Frame_Shift_Del_p.P411fs|SLC23A2_uc002wli.2_Frame_Shift_Del_p.P410fs	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	411					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						TTGCGTGGATGGGGGGGGGTG	0.527			NA											7	147	---	---	---	---	NA	NA	NA	NA	NA
PAK7	57144	broad.mit.edu	37	20	9561435	9561435	+	Frame_Shift_Del	DEL	C	C	-	rs142065974	byFrequency	TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:9561435delC	uc002wnl.2	-	5	892	c.347delG	c.(346-348)GGTfs	p.G116fs	PAK7_uc002wnk.2_Frame_Shift_Del_p.G116fs|PAK7_uc002wnj.2_Frame_Shift_Del_p.G116fs|PAK7_uc010gby.1_Frame_Shift_Del_p.G116fs	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	116	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			GTGGCCTGGACCGTGGCTGGA	0.542			NA											40	207	---	---	---	---	NA	NA	NA	NA	NA
KIAA1755	85449	broad.mit.edu	37	20	36869444	36869447	+	Frame_Shift_Del	DEL	GTGG	GTGG	-			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	GTGG	GTGG	-	-	GTGG	GTGG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:36869444_36869447delGTGG	uc002xhy.1	-	3	1358_1361	c.1086_1089delCCAC	c.(1084-1089)ACCCACfs	p.T362fs	KIAA1755_uc002xhz.1_Frame_Shift_Del_p.T362fs	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	362_363										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				TTTCTGAGTTGTGGGTGGGTGCTT	0.544			NA											49	384	---	---	---	---	NA	NA	NA	NA	NA
FAM83D	81610	broad.mit.edu	37	20	37580383	37580383	+	Frame_Shift_Del	DEL	G	G	-			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr20:37580383delG	uc002xjg.2	+	4	1109	c.1068delG	c.(1066-1068)CTGfs	p.L356fs		NM_030919	NP_112181	Q9H4H8	FA83D_HUMAN	hypothetical protein LOC81610	326					cell division|mitosis	cytoplasm|spindle pole				ovary(3)	3		Myeloproliferative disorder(115;0.00878)				AGCTCACCCTGGGCAACCTGC	0.597			NA											9	133	---	---	---	---	NA	NA	NA	NA	NA
KRTAP10-6	386674	broad.mit.edu	37	21	46011972	46011972	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr21:46011972delC	uc002zfm.2	-	1	415	c.394delG	c.(394-396)GATfs	p.D132fs	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198688	NP_941961	P60371	KR106_HUMAN	keratin associated protein 10-6	132	29 X 5 AA repeats of C-C-X(3).|10.					keratin filament					0						CATGAAGAATCCCCACAGCAG	0.637			NA											17	55	---	---	---	---	NA	NA	NA	NA	NA
FBN2	2201	broad.mit.edu	37	5	127681105	127681105	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr5:127681105delC	uc003kuu.2	-	24	3600	c.3161delG	c.(3160-3162)CGCfs	p.R1054fs	FBN2_uc003kuv.2_Frame_Shift_Del_p.R1021fs	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1054					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GCCAGCCCCGCGGGGGCACAG	0.622			NA											16	112	---	---	---	---	NA	NA	NA	NA	NA
DNAH8	1769	broad.mit.edu	37	6	38750806	38750806	+	Frame_Shift_Del	DEL	G	G	-	rs141715565		TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr6:38750806delG	uc003ooe.1	+	15	2235	c.1635delG	c.(1633-1635)CCGfs	p.P545fs		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TATCAAGTCCGGACGGTAAAG	0.368			NA											8	73	---	---	---	---	NA	NA	NA	NA	NA
LAT2	7462	broad.mit.edu	37	7	73630349	73630357	+	In_Frame_Del	DEL	TGGTGCTGT	TGGTGCTGT	-			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	TGGTGCTGT	TGGTGCTGT	-	-	TGGTGCTGT	TGGTGCTGT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:73630349_73630357delTGGTGCTGT	uc003uag.2	+	3	594_602	c.44_52delTGGTGCTGT	c.(43-54)CTGGTGCTGTTG>CTG	p.15_18LVLL>L	RFC2_uc011kfa.1_Intron|LAT2_uc003uah.2_In_Frame_Del_p.15_18LVLL>L|LAT2_uc003uai.2_In_Frame_Del_p.15_18LVLL>L|LAT2_uc010lbo.2_RNA	NM_032464	NP_115853	Q9GZY6	NTAL_HUMAN	linker for activation of T cells family member	15_18	Helical; Signal-anchor for type III membrane protein; (Potential).				B cell activation|B cell receptor signaling pathway|calcium-mediated signaling|mast cell degranulation	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding				0						GCAGCGCTGCTGGTGCTGTTGGGGGTGGC	0.632			NA											13	116	---	---	---	---	NA	NA	NA	NA	NA
FAM131B	9715	broad.mit.edu	37	7	143053878	143053878	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:143053878delC	uc003wct.2	-	6	2470	c.764delG	c.(763-765)GGAfs	p.G255fs	FAM131B_uc010loz.2_Frame_Shift_Del_p.G223fs|FAM131B_uc003wcu.3_Frame_Shift_Del_p.G255fs|FAM131B_uc010lpa.2_Frame_Shift_Del_p.G283fs	NM_014690	NP_055505	Q86XD5	F131B_HUMAN	hypothetical protein LOC9715 isoform b	255											0	Melanoma(164;0.205)					GTCAGTGTCTCCCCCCAGCAA	0.607			NA											36	140	---	---	---	---	NA	NA	NA	NA	NA
CNTNAP2	26047	broad.mit.edu	37	7	146536957	146536958	+	Frame_Shift_Ins	INS	-	-	T			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chr7:146536957_146536958insT	uc003weu.1	+	3	879_880	c.363_364insT	c.(361-366)GGGAGAfs	p.G121fs		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	121_122	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GCGACACAGGGAGAAACTGGAA	0.45			NA								HNSCC(39;0.1)			13	36	---	---	---	---	NA	NA	NA	NA	NA
KDM6A	7403	broad.mit.edu	37	X	44969432	44969432	+	Frame_Shift_Del	DEL	T	T	-			TCGA-75-5126-01A-01D-1753-08	TCGA-75-5126-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1c1ad138-a59e-4f5d-8382-54c585c9298c	dc6811d5-d075-4023-93a5-3a26c10fcd65	g.chrX:44969432delT	uc004dge.3	+	28	4489	c.4114delT	c.(4114-4116)TTTfs	p.F1372fs	KDM6A_uc011mkz.1_Frame_Shift_Del_p.F1424fs|KDM6A_uc011mla.1_Frame_Shift_Del_p.F1327fs|KDM6A_uc011mlb.1_Frame_Shift_Del_p.F1379fs|KDM6A_uc011mlc.1_Frame_Shift_Del_p.F1076fs|KDM6A_uc011mld.1_Frame_Shift_Del_p.F1011fs	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1372					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						CTTGGAAAACTTTGTGGTGCT	0.378	Colon(129;1273 1667 15230 27352 52914)		NA	D|N|F|S		renal|oesophageal SCC|MM								28	117	---	---	---	---	NA	NA	NA	NA	NA
